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Sample records for artificial disc activ

  1. The activArtificial Disc: a next-generation motion-preserving implant for chronic lumbar discogenic pain

    Directory of Open Access Journals (Sweden)

    Yue JJ

    2016-05-01

    Full Text Available James J Yue,1 Rolando Garcia Jr,2 Larry E Miller3 1Department of Orthopaedic Surgery, Yale School of Medicine, New Haven, CT, 2Orthopedic Care Center, Miami, FL, 3Miller Scientific Consulting, Inc., Asheville, NC, USA Abstract: Degeneration of the lumbar intervertebral discs is a leading cause of chronic low back pain in adults. Treatment options for patients with chronic lumbar discogenic pain unresponsive to conservative management include total disc replacement (TDR or lumbar fusion. Until recently, only two lumbar TDRs had been approved by the US Food and Drug Administration - the Charité Artificial Disc in 2004 and the ProDisc-L Total Disc Replacement in 2006. In June 2015, a next-generation lumbar TDR received Food and Drug Administration approval - the activArtificial Disc (Aesculap Implant Systems. Compared to previous-generation lumbar TDRs, the activArtificial Disc incorporates specific design enhancements that result in a more precise anatomical match and allow a range of motion that better mimics the healthy spine. The results of mechanical and clinical studies demonstrate that the activArtificial Disc results in improved mechanical and clinical outcomes versus earlier-generation artificial discs and compares favorably to lumbar fusion. The purpose of this report is to describe the activL® Artificial Disc including implant characteristics, intended use, surgical technique, postoperative care, mechanical testing, and clinical experience to date. Keywords: activArtificial Disc, artificial disc, degenerative disc disease, discogenic, implant, lumbar, motion preservation, pain

  2. The activL(®) Artificial Disc: a next-generation motion-preserving implant for chronic lumbar discogenic pain.

    Science.gov (United States)

    Yue, James J; Garcia, Rolando; Miller, Larry E

    2016-01-01

    Degeneration of the lumbar intervertebral discs is a leading cause of chronic low back pain in adults. Treatment options for patients with chronic lumbar discogenic pain unresponsive to conservative management include total disc replacement (TDR) or lumbar fusion. Until recently, only two lumbar TDRs had been approved by the US Food and Drug Administration - the Charité Artificial Disc in 2004 and the ProDisc-L Total Disc Replacement in 2006. In June 2015, a next-generation lumbar TDR received Food and Drug Administration approval - the activL(®) Artificial Disc (Aesculap Implant Systems). Compared to previous-generation lumbar TDRs, the activL(®) Artificial Disc incorporates specific design enhancements that result in a more precise anatomical match and allow a range of motion that better mimics the healthy spine. The results of mechanical and clinical studies demonstrate that the activL(®) Artificial Disc results in improved mechanical and clinical outcomes versus earlier-generation artificial discs and compares favorably to lumbar fusion. The purpose of this report is to describe the activL(®) Artificial Disc including implant characteristics, intended use, surgical technique, postoperative care, mechanical testing, and clinical experience to date.

  3. Clinical study to evaluate the safety and effectiveness of the Aesculap Activ-L™ artificial disc in the treatment of degenerative disc disease

    Directory of Open Access Journals (Sweden)

    Mo Fred F

    2010-04-01

    Full Text Available Abstract Background The objective of this clinical study is to evaluate the safety and effectiveness of the Activ-L Artificial Disc for treatment of single-level degenerative disc disease of the lumbar spine in patients who have been unresponsive to at least six months of prior conservative care. The hypothesis of the study is that the Activ-L Disc is non-inferior to the control (the Charité® Artificial Disc [DePuy Spine] or ProDisc-L® Total Disc Replacement [Synthes Spine] with respect to the rate of individual subject success at 24 months. Individual subject success is a composite of effectiveness and safety. Methods/Design The study proposed is a prospective, randomized, single-masked, controlled, multi-center clinical trial consisting of an estimated 414 subjects with single-level DDD of the lumbar spine (L4/L5, or L5/S1 who have failed to improve with conservative treatment for at least six months prior to enrollment. After enrollment, subjects will be randomized in a 2:1 ratio to either the Activ-L Disc (investigational device or the control (Charité or ProDisc-L. Radiographic endpoints will be evaluated by an independent reviewer at an imaging core laboratory. Each subject will be followed for 5 years post-treatment. Discussion The safety and effectiveness of the Activ-L Artificial Disc for treatment of single-level degenerative disc disease of the lumbar spine will be equivalent to Charité® Artificial Disc [DePuy Spine] or ProDisc-L® Total Disc Replacement [Synthes Spine] at 24 months. Trial Registration Current Controlled Trials NCT00589797.

  4. The artificial disc: theory, design and materials.

    Science.gov (United States)

    Bao, Q B; McCullen, G M; Higham, P A; Dumbleton, J H; Yuan, H A

    1996-06-01

    Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: discectomy and fusion. Although discectomy and fusion produce a relatively good short-term clinical result in relieving pain, both these surgical treatments alter the biomechanics of the spine, possibly leading to further degeneration of the surrounding tissues and the discs at adjacent levels. Over the past 35 years, a tremendous effort has been made to develop an artificial disc to replace the degenerated disc. The goal is the restoration of the natural biomechanics of the segment after disc excision, thus relieving pain and preventing further degeneration at adjacent segments. However, the artificial disc faces a complex biomechanical environment which makes replication of the biomechanics difficult and long-term survival challenging to designs and materials. The purpose of this article is to examine the factors of importance in designing a disc replacement. Topics covered include the structure and function of the natural disc, the changes that occur with disc degeneration and existing methods of treatment for the degenerative spine. The progress in achieving a functional, long-lasting disc replacement is outlined.

  5. Improving the fixation of an artificial intervertebral disc

    NARCIS (Netherlands)

    Eijkelkamp, MF; Hayen, J; Veldhuizen, AG; Van Horn, [No Value; Verkerke, GJ

    2002-01-01

    The fixation of an artificial intervertebral disc has been studied especially with respect to the dimensions, the convexity of the endplates and the size of the fixation elements. From literature and cadaveric vertebrae, the dimensions and shape of the lumbar vertebral endplates were determined and

  6. The Research of Artificial Cervical Disc Replacement

    Institute of Scientific and Technical Information of China (English)

    Zhao Zhua; Qiang Shenb

    2008-01-01

    Cervical arthroplasty after anterior decompression with insertion of a prosthetic total disc replacement has been suggested as an alternate to anterior cervical fusion. It develops quickly during recent years. Currently there are several cervical arthroplasty devices. Each device varies in terms of materials, range of motion and constraint. Early studies suggest that in the short term, the complication rate and efficacy is no worse than fusion surgery. Long-term results have not yet been reported. This review examines the current prostheses as well as discussing issues regarding indications and technique. It is hoped that an improvement of cervical arthroplasty occurs in terms of materials and design as spinal surgeons enter a new dines of the management of cervical spine disease.

  7. Medium-term outcomes of artificial disc replacement for severe cervical disc narrowing

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    Chao-Hung Yeh

    2014-01-01

    Conclusions: Acceptable clinical outcome for treatment of severe cervical disc narrowing with cervical disc replacement technique has been performed in current study. Most patients maintained good postoperative mobility and no significant adjacent level degeneration were found. Cervical disc replacement may be applicable in treatment of severe cervical disc narrowing; however, longer follow-ups are required for ensuring the long-term efficacy of cervical disc replacement.

  8. Do design variations in the artificial disc influence cervical spine biomechanics? A finite element investigation

    OpenAIRE

    Faizan, Ahmad; Goel, Vijay K.; Garfin, Steven R.; Serhan, Hassan; Biyani, Ashok; Elgafy, Hossein; Krishna, Manoj; Friesem, Tai; Bono, Christopher M

    2009-01-01

    Various ball and socket-type designs of cervical artificial discs are in use or under investigation. Many artificial disc designs claim to restore the normal kinematics of the cervical spine. What differentiates one type of design from another design is currently not well understood. In this study, authors examined various clinically relevant parameters using a finite element model of C3–C7 cervical spine to study the effects of variations of ball and socket disc designs. Four variations of b...

  9. Medium-term outcomes of artificial disc replacement for severe cervical disc narrowing

    Institute of Scientific and Technical Information of China (English)

    Chao-Hung Yeh; Che-Wei Hung; Cheng-Hsing Kao; Chien-Ming Chao

    2014-01-01

    Objective:To determine if theBryan cervical disc prosthesis could relieve objective neurological symptoms, signs, and restore mobility in patients with severe cervical disc narrowing. Methods:Clinical data of thirty-two patients underwentBryan cervical disc replacement has been collected fromApril2006 toFebruary2010.Severe cervical disc narrowing with gradeV disc degeneration were included in this study.Bryan cervical disc prostheses have been implanted through anterior approach.JapaneseOrthopedicsAssociation(JOA) score, visual analog scale, Odom’s scale, and flexion-extension radiological follow-ups were applied for evaluations. Results:A total of41Bryan disc prostheses from32 patients with an average follow-up duration of33.5 months(range23 to44 months) were evaluated.Clinical functions of patients were significantly improved.Preoperative averaged visual analog scale score of6.3±2.2 was decreased to1.3±1.2(at36 months,P<0.001), while preoperative averagedJOA score of14.4±1.2 was increased to16.3±0.9(at36 months,P<0.001).Thirty of32 patients received excellent to good outcomes inOdom’s scale.Averaged mobility was restored to(9.9±3.2)°at the last follow-up evaluation of36 months.No subsidence or migration of implant was identified. Conclusions:Acceptable clinical outcome for treatment of severe cervical disc narrowing with cervical disc replacement technique has been performed in current study.Most patients maintained good postoperative mobility and no significant adjacent level degeneration were found.Cervical disc replacement may be applicable in treatment of severe cervical disc narrowing; however, longer follow-ups are required for ensuring the long-term efficacy of cervical disc replacement.

  10. Do design variations in the artificial disc influence cervical spine biomechanics? A finite element investigation.

    Science.gov (United States)

    Faizan, Ahmad; Goel, Vijay K; Garfin, Steven R; Bono, Christopher M; Serhan, Hassan; Biyani, Ashok; Elgafy, Hossein; Krishna, Manoj; Friesem, Tai

    2012-06-01

    Various ball and socket-type designs of cervical artificial discs are in use or under investigation. Many artificial disc designs claim to restore the normal kinematics of the cervical spine. What differentiates one type of design from another design is currently not well understood. In this study, authors examined various clinically relevant parameters using a finite element model of C3-C7 cervical spine to study the effects of variations of ball and socket disc designs. Four variations of ball and socket-type artificial disc were placed at the C5-C6 level in an experimentally validated finite element model. Biomechanical effects of the shape (oval vs. spherical ball) and location (inferior vs. superior ball) were studied in detail. Range of motion, facet loading, implant stresses and capsule ligament strains were computed to investigate the influence of disc designs on resulting biomechanics. Motions at the implant level tended to increase following disc replacement. No major kinematic differences were observed among the disc designs tested. However, implant stresses were substantially higher in the spherical designs when compared to the oval designs. For both spherical and oval designs, the facet loads were lower for the designs with an inferior ball component. The capsule ligament strains were lower for the oval design with an inferior ball component. Overall, the oval design with an inferior ball component, produced motion, facet loads, implant stresses and capsule ligament strains closest to the intact spine, which may be key to long-term implant survival.

  11. Cervical disc arthroplasty with ProDisc-C artificial disc: 5-year radiographic follow-up results

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yan-bin; SUN Yu; ZHOU Fei-fei; LIU ZHONG-jun

    2013-01-01

    Background Cervical disc arthroplasty is an alternative surgery to standard cervical decompression and fusion for disc degeneration.Different types of cervical disc prosthesis are used in China.The aim of this study was to evaluate the radiographic outcomes of cervical arthroplasty using the ProDisc-C prosthesis.Methods Radiographic evaluation,including static and dynamic flexion-extension lateral images,was performed at baseline and at final follow-up.Results Twenty six patients who had single-level ProDisc-C arthroplasty were followed up for a mean period of 63 months (56-76 months).The range of motion at the operated level was 9.3°±3.7° at baseline and 7.3°±3.5° at final follow-up,with a significant difference (P <0.05).Seventeen of 26 levels (65.4%) developed heterotopic ossification:three were classified as grade Ⅱ,13 were classified as grade Ⅲ,and 1 as grade Ⅳ,according to McAfee's classification.Forty nine adjacent segments were evaluated by lateral Ⅹ-ray and 18 (36.7%) segments developed adjacent segment degenerations.Conclusions ProDisc-C arthroplasty had acceptable radiographic results at 5-year follow-up.The range of motion was preserved.However,more than 60% of the patients developed heterotopic ossification.

  12. Frisbee - the first artificial cervical disc of 3RD generation

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    Karin Büttner-Janz

    2014-03-01

    Full Text Available OBJECTIVE: The current cervical disc arthroplasty is limited by postoperative facet joint arthritis, heterotopic ossification and segmental kyphosis. The total Frisbee disc, which has an upper convex/concave non-spherical surface and a lower flat sliding surface, is a new approach for improved outcomes. Prior to clinical application, safety and suitability tests are required. METHODS: The Frisbee is the first 3rd generation disc according to a new classification of total disc because it can precisely mimic the segmental ROM, including the soft limitation of axial rotation. The ISO 18192-1 test was carried out to determine the rate of wear debris. A FE model was used to assess the safety of prosthetic components. In the sagittal plane several variables to determine the most favorable lordotic angle were evaluated. RESULTS: Two angled prosthetic plates are safer than one sliding angled core to prevent the displacement. The lordosis of 7° of the Frisbee leads to kyphosis of no more than 2° without reduction of the ROM. The wear rate of the Frisbee is five times smaller compared to an FDA-approved disc with a spherical sliding surface. CONCLUSIONS: Based on the test results, the clinical application of Frisbee can now be studied. The postoperative kyphosis observed with other devices is not an issue with the Frisbee design. Physiological ROM is combined with the significant reduction of wear debris. For these reasons the Frisbee has the potential to provide a better balanced segmental loading reducing the degeneration of the joint surface and heterotopic ossification.

  13. Artificial cervical disc replacement: Principles, types and techniques

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    Sekhon L

    2005-01-01

    Full Text Available Cervical arthroplasty after anterior decompression with insertion of a prosthetic total disc replacement has been suggested as an alternate to anterior cervical fusion. Currently there are four cervical arthroplasty devices available on the market whose results in clinical use have been reported. Each device varies in terms of materials, range of motion, insertion technique and constraint. It is not known which device is ideal. Early studies suggest that in the short term, the complication rate and efficacy is no worse than fusion surgery. Long-term results have not yet been reported. This review examines the current prostheses available on the market as well as discussing issues regarding indications and technique. Pitfalls are discussed and early experiences reviewed. In time, it is hoped that a refinement of cervical arthroplasty occurs in terms of both materials and design as well as in terms of indications and clinical outcomes as spinal surgeons enter a new era of the management of cervical spine disease.

  14. Long term preservation of motion with artificial cervical disc implants: A comparison between cervical disc replacement and rigid fusion with cage

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    Cincu, Rafael; Lorente, Francisco de Asis; Gomez, Joaquin; Eiras, Jose; Agrawal, Amit

    2014-01-01

    Background: With the advancement of technologies there is more interest in the maintenance of the spine's biomechanical properties focusing on the preservation of the functional motion segment. In present article we describe our experience with 25 cases managed with artificial cervical discs with 28 Solis cage following cervical discectomy with a mean follow-up period of 7.5 year. Materials and Methods: All surgeries were performed by single surgeon from March 2004 to June 2005 with a follow-up till date. Patients with symptomatic single or multiple level diseases that had no prior cervical surgery were candidates for the study. Cohort demographics were comparable. Standardized clinical outcome measures and radiographic examinations were used at prescribed post-operative intervals to compare the treatment groups. Relief in radicular pain, cervical spine motion, and degenerative changes at follow-up were noted. Results: In a total 53 cases, the mean age in prosthesis group was 47 years (age range: 30-63 years) and mean age in cage group was 44 years (32-62 years). Mean hospital stay was 2.7 days in both the groups. At 4 weeks complete cervical movements could be achieved in 19 cases in artificial disc group. Maintenance of movement after 7.5 years was in 76% of these patients. Lordosis was maintained in all cases till date. There was no mortality or wound infection in our series. Conclusions: We conclude that artificial cervical disc could be an alternative to fixed spinal fusion as it represents the most physiological substitute of disc. However, there is need for further studies to support the use of artificial cervical disc prosthesis. PMID:25685218

  15. Biomechanics of a posture-controlling cervical artificial disc: mechanical, in vitro, and finite-element analysis.

    Science.gov (United States)

    Crawford, Neil R; Arnett, Jeffery D; Butters, Joshua A; Ferrara, Lisa A; Kulkarni, Nikhil; Goel, Vijay K; Duggal, Neil

    2010-06-01

    Different methods have been described by numerous investigators for experimentally assessing the kinematics of cervical artificial discs. However, in addition to understanding how artificial discs affect range of motion, it is also clinically relevant to understand how artificial discs affect segmental posture. The purpose of this paper is to describe novel considerations and methods for experimentally assessing cervical spine postural control in the laboratory. These methods, which include mechanical testing, cadaveric testing, and computer modeling studies, are applied in comparing postural biomechanics of a novel postural control arthroplasty (PCA) device versus standard ball-and-socket (BS) and ball-in-trough (BT) arthroplasty devices. The overall body of evidence from this group of tests supports the conclusion that the PCA device does control posture to a particular lordotic position, whereas BS and BT devices move freely through their ranges of motion.

  16. Effect of an artificial disc on lumbar spine biomechanics: a probabilistic finite element study.

    Science.gov (United States)

    Rohlmann, Antonius; Mann, Anke; Zander, Thomas; Bergmann, Georg

    2009-01-01

    The effects of different parameters on the mechanical behaviour of the lumbar spine were in most cases determined deterministically with only one uncertain parameter varied at a time while the others were kept fixed. Thus most parameter combinations were disregarded. The aim of the study was to determine in a probabilistic finite element study how intervertebral rotation, intradiscal pressure, and contact force in the facet joints are affected by the input parameters implant position, implant ball radius, presence of scar tissue, and gap size in the facet joints. An osseoligamentous finite element model of the lumbar spine ranging from L3 vertebra to L5/S1 intervertebral disc was used. An artificial disc with a fixed center of rotation was inserted at level L4/L5. The model was loaded with pure moments of 7.5 Nm to simulate flexion, extension, lateral bending, and axial torsion. In a probabilistic study the implant position in anterior-posterior (ap) and in lateral direction, the radius of the implant ball, and the gap size of the facet joint were varied. After implanting an artificial disc, scar tissue may develop, replacing the anterior longitudinal ligament. Thus presence and absence of scar tissue were also simulated. For each loading case studied, intervertebral rotations, intradiscal pressures and contact forces in the facet joints were calculated for 1,000 randomized input parameter combinations in order to determine the probable range of these output parameters. Intervertebral rotation at implant level varies strongly for different combinations of the input parameters. It is mainly affected by gap size, ap-position and implant ball radius for flexion, by scar tissue and implant ball radius for extension and lateral bending, and by gap size and implant ball radius for axial torsion. For extension, intervertebral rotation at implant level varied between 1.4 degrees and 7.5 degrees . Intradiscal pressure in the adjacent discs is only slightly affected by all

  17. Notch inhibits Yorkie activity in Drosophila wing discs.

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    Alexandre Djiane

    Full Text Available During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki, the Salvador/Warts/Hippo (SWH pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg. We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.

  18. Artificial disc and vertebra system: a novel motion preservation device for cervical spinal disease after vertebral corpectomy

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    Jun Dong

    2015-07-01

    Full Text Available OBJECTIVE: To determine the range of motion and stability of the human cadaveric cervical spine after the implantation of a novel artificial disc and vertebra system by comparing an intact group and a fusion group. METHODS: Biomechanical tests were conducted on 18 human cadaveric cervical specimens. The range of motion and the stability index range of motion were measured to study the function and stability of the artificial disc and vertebra system of the intact group compared with the fusion group. RESULTS: In all cases, the artificial disc and vertebra system maintained intervertebral motion and reestablished vertebral height at the operative level. After its implantation, there was no significant difference in the range of motion (ROM of C3-7 in all directions in the non-fusion group compared with the intact group (p>0.05, but significant differences were detected in flexion, extension and axial rotation compared with the fusion group (p<0.05. The ROM of adjacent segments (C3-4, C6-7 of the non-fusion group decreased significantly in some directions compared with the fusion group (p<0.05. Significant differences in the C4-6 ROM in some directions were detected between the non-fusion group and the intact group. In the fusion group, the C4-6 ROM in all directions decreased significantly compared with the intact and non-fusion groups (p<0.01. The stability index ROM (SI-ROM of some directions was negative in the non-fusion group, and a significant difference in SI-ROM was only found in the C4-6 segment of the non-fusion group compared with the fusion group. CONCLUSION: An artificial disc and vertebra system could restore vertebral height and preserve the dynamic function of the surgical area and could theoretically reduce the risk of adjacent segment degeneration compared with the anterior fusion procedure. However, our results should be considered with caution because of the low power of the study. The use of a larger sample should be

  19. Miconazole activity against Candida biofilms developed on acrylic discs.

    Science.gov (United States)

    Gebremedhin, S; Dorocka-Bobkowska, B; Prylinski, M; Konopka, K; Duzgunes, N

    2014-08-01

    Oral candidiasis in the form of Candida-associated denture stomatitis (CaDS) is associated with Candida adhesion and biofilm formation on the fitting surface of poly (methyl methacrylate) (PMMA) dentures. Candida biofilms show considerable resistance to most conventional antifungal agents, a phenomenon that is considered a developmental-phase-specific event that may help explain the high recurrence rates associated with CaDS. The aim of this study was to examine the activity of miconazole towards in vitro-grown mature Candida biofilms formed on heat-cured PMMA discs as a standardized model. The effect of miconazole nitrate on Candida biofilms developed on acrylic discs was determined for C. albicans MYA-2732 (ATCC), C. glabrata MYA-275 (ATCC), and clinical isolates, C. albicans 6122/06, C. glabrata 7531/06, C. tropicalis 8122/06, and C. parapsilosis 11375/07. Candida biofilms were developed on heat-cured poly(methyl methacrylate) discs and treated with miconazole (0.5 - 96 μg/ml). The metabolic activity of the biofilms was measured by the XTT reduction assay. The minimum inhibitory concentrations (MICs) of miconazole against Candida species were determined by the microdilution method. The MICs for miconazole for the investigated strains ranged from 0.016-32 μg/ml. Treatment with miconazole resulted in a significant reduction of biofilm metabolic activity for all strains. The highest inhibition was observed at 96 μg/ml miconazole. In the case of C. glabrata MYA-275 and C. tropicalis 8122/06 this corresponded to 83.7% and 75.4% inhibition, respectively. The lowest reduction was observed for C. parapsilosis 11375/07-46.1%. For all Candida strains there was a strong correlation between MIC values and miconazole concentrations corresponding to a reduction of metabolic activity of the biofilm by 50%. Miconazole exhibits high antifungal activity against Candida biofilms developed on the surface of PMMA discs. The study provides support for the use of miconazole as an

  20. Mechanically activated artificial cell by using microfluidics.

    Science.gov (United States)

    Ho, Kenneth K Y; Lee, Lap Man; Liu, Allen P

    2016-01-01

    All living organisms sense mechanical forces. Engineering mechanosensitive artificial cell through bottom-up in vitro reconstitution offers a way to understand how mixtures of macromolecules assemble and organize into a complex system that responds to forces. We use stable double emulsion droplets (aqueous/oil/aqueous) to prototype mechanosensitive artificial cells. In order to demonstrate mechanosensation in artificial cells, we develop a novel microfluidic device that is capable of trapping double emulsions into designated chambers, followed by compression and aspiration in a parallel manner. The microfluidic device is fabricated using multilayer soft lithography technology, and consists of a control layer and a deformable flow channel. Deflections of the PDMS membrane above the main microfluidic flow channels and trapping chamber array are independently regulated pneumatically by two sets of integrated microfluidic valves. We successfully compress and aspirate the double emulsions, which result in transient increase and permanent decrease in oil thickness, respectively. Finally, we demonstrate the influx of calcium ions as a response of our mechanically activated artificial cell through thinning of oil. The development of a microfluidic device to mechanically activate artificial cells creates new opportunities in force-activated synthetic biology.

  1. Mechanically activated artificial cell by using microfluidics

    Science.gov (United States)

    Ho, Kenneth K. Y.; Lee, Lap Man; Liu, Allen P.

    2016-01-01

    All living organisms sense mechanical forces. Engineering mechanosensitive artificial cell through bottom-up in vitro reconstitution offers a way to understand how mixtures of macromolecules assemble and organize into a complex system that responds to forces. We use stable double emulsion droplets (aqueous/oil/aqueous) to prototype mechanosensitive artificial cells. In order to demonstrate mechanosensation in artificial cells, we develop a novel microfluidic device that is capable of trapping double emulsions into designated chambers, followed by compression and aspiration in a parallel manner. The microfluidic device is fabricated using multilayer soft lithography technology, and consists of a control layer and a deformable flow channel. Deflections of the PDMS membrane above the main microfluidic flow channels and trapping chamber array are independently regulated pneumatically by two sets of integrated microfluidic valves. We successfully compress and aspirate the double emulsions, which result in transient increase and permanent decrease in oil thickness, respectively. Finally, we demonstrate the influx of calcium ions as a response of our mechanically activated artificial cell through thinning of oil. The development of a microfluidic device to mechanically activate artificial cells creates new opportunities in force-activated synthetic biology. PMID:27610921

  2. Artificial light and nocturnal activity in gammarids

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    Elizabeth K. Perkin

    2014-03-01

    Full Text Available Artificial light is gaining attention as a potential stressor to aquatic ecosystems. Artificial lights located near streams increase light levels experienced by stream invertebrates and we hypothesized light would depress night drift rates. We also hypothesized that the effect of light on drift rates would decrease over time as the invertebrates acclimated to the new light level over the course of one month’s exposure. These hypotheses were tested by placing Gammarus spp. in eight, 75 m × 1 m artificial flumes. One flume was exposed to strong (416 lx artificial light at night. This strong light created a gradient between 4.19 and 0.04 lx over the neighboring six artificial flumes, while a control flume was completely covered with black plastic at night. Night-time light measurements taken in the Berlin area confirm that half the flumes were at light levels experienced by urban aquatic invertebrates. Surprisingly, no light treatment affected gammarid drift rates. In contrast, physical activity measurements of in situ individually caged G. roeseli showed they increased short-term activity levels in nights of complete darkness and decreased activity levels in brightly lit flumes. Both nocturnal and diurnal drift increased, and day drift rates were unexpectadly higher than nocturnal drift.

  3. Mechanically activated artificial cell by using microfluidics

    Science.gov (United States)

    Ho, Kenneth K. Y.; Lee, Lap Man; Liu, Allen P.

    2016-09-01

    All living organisms sense mechanical forces. Engineering mechanosensitive artificial cell through bottom-up in vitro reconstitution offers a way to understand how mixtures of macromolecules assemble and organize into a complex system that responds to forces. We use stable double emulsion droplets (aqueous/oil/aqueous) to prototype mechanosensitive artificial cells. In order to demonstrate mechanosensation in artificial cells, we develop a novel microfluidic device that is capable of trapping double emulsions into designated chambers, followed by compression and aspiration in a parallel manner. The microfluidic device is fabricated using multilayer soft lithography technology, and consists of a control layer and a deformable flow channel. Deflections of the PDMS membrane above the main microfluidic flow channels and trapping chamber array are independently regulated pneumatically by two sets of integrated microfluidic valves. We successfully compress and aspirate the double emulsions, which result in transient increase and permanent decrease in oil thickness, respectively. Finally, we demonstrate the influx of calcium ions as a response of our mechanically activated artificial cell through thinning of oil. The development of a microfluidic device to mechanically activate artificial cells creates new opportunities in force-activated synthetic biology.

  4. Convergence of simulations of self-gravitating accretion discs II: Sensitivity to the implementation of radiative cooling and artificial viscosity

    CERN Document Server

    Rice, W K M; Forgan, D H; Armitage, P J

    2013-01-01

    Recently it has been suggested that the fragmentation boundary in Smoothed Particle Hydrodynamic (SPH) and FARGO simulations of self-gravitating accretion discs with beta-cooling do not converge as resolution is increased. Furthermore, this recent work suggests that by carefully optimising the artificial viscosity parameters in these codes it can be shown that fragmentation may occur for much longer cooling times than earlier work suggests. If correct, this result is intriguing as it suggests that gas giant planets could form, via direct gravitational collapse, reasonably close to their parent stars. This result is, however, slightly surprising and there have been a number of recent studies suggesting that the result is likely an indication of a numerical problem with the simulations. One suggestion, in particular, is that the SPH results are influenced by the manner in which the cooling is implemented. We extend this work here and show that if the cooling is implemented in a manner that removes a known numer...

  5. 角度人工椎间盘置换后对相邻下位椎间隙应力的影响%Effects of artificial disc replacement with angles on stress of adjacent intervertebral disc

    Institute of Scientific and Technical Information of China (English)

    柏传毅; 张维杰; 卫文博; 凌伟; 田振兴; 党晓谦; 王坤正

    2014-01-01

    Objective:To evaluate stress changes of intervertebral space and adjacent intervertebral space after artificial disc replacement with angles. Methods:Artificial disc replacement with angles were designed according to existing data. Axial pressure,flexion/extension,lateral bending and torsion loading were applied on finite element models of normal cervical discs on C4,5 segments,C4,5 segments with 0°artificial cervical discs and C4,5 segments with 10°artificial cervical discs,then stress changes of C4,5 space was observed. The same loadings were applied on finite element models of normal cervical discs on C 4-C6 segments,C4,5 segments with 0°,C4,5 segments with 10°,then stress changes of replaced segments space and adjacent segment space were observed. Results:For C4,5 segments,80 MPa/0°artificial discs and 80 MPa/10°artificial discs had the similar e-quivalent shear stress(Se),and were both larger than that of normal discs,when lateral bending were performed,80 MPa/0°ar-tificial discs were closed to normal discs when axial pressure and flexion/extension were carried out ,while 80 MPa/10°artifi-cial discs had a larger Se than that of normal ones,when torsion loading were applied,Szx/Szy stress of 80 MPa/0°and 80 MPa/10°artificial discs were closed to normal ones. For C4-C6 segments,the axial pressure,flexion/extension and lateral bend-ing of C5,6 were all lower than normal discs after C4,5 discs were replaced by 80 MPa/10°artificial discs,while Szx/Szy of torsion loading were closed to normal ones. Conclusion:Artificial discs with 10° have less influences on stress of adjacent interverte-bral space and closer to mechanical property after being implanted into intervertebral space.%目的:探讨带角度人工颈椎间盘置换后椎间隙及相邻椎间隙应力变化。方法:根据已有的测量结果,设计角度人工椎间盘。对已建立的C4,5两节段带椎间盘的正常颈椎有限元模型、C4,5置换0°椎间盘假体和置换10

  6. Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels

    NARCIS (Netherlands)

    Rutges, J. P. H. J.; Kummer, J. A.; Oner, F. C.; Verbout, A. J.; Roestenburg, H. J. A.; Dhert, W. J. A.; Creemers, L. B.

    2008-01-01

    Intervertebral disc (IVD) degeneration is associated with the increased expression of several matrix metalloproteinases (MMPs), in particular MMP-2. However, little is known about the actual activity of MMP-2 in healthy and degenerated discs, or what mechanisms are involved in its activation. A majo

  7. Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse.

    Science.gov (United States)

    Winkler, Tamara; Mahoney, Eric J; Sinner, Debora; Wylie, Christopher C; Dahia, Chitra Lekha

    2014-01-01

    Intervertebral discs (IVDs) are strong fibrocartilaginous joints that connect adjacent vertebrae of the spine. As discs age they become prone to failure, with neurological consequences that are often severe. Surgical repair of discs treats the result of the disease, which affects as many as one in seven people, rather than its cause. An ideal solution would be to repair degenerating discs using the mechanisms of their normal differentiation. However, these mechanisms are poorly understood. Using the mouse as a model, we previously showed that Shh signaling produced by nucleus pulposus cells activates the expression of differentiation markers, and cell proliferation, in the postnatal IVD. In the present study, we show that canonical Wnt signaling is required for the expression of Shh signaling targets in the IVD. We also show that Shh and canonical Wnt signaling pathways are down-regulated in adult IVDs. Furthermore, this down-regulation is reversible, since re-activation of the Wnt or Shh pathways in older discs can re-activate molecular markers of the IVD that are lost with age. These data suggest that biological treatments targeting Wnt and Shh signaling pathways may be feasible as a therapeutic for degenerative disc disease.

  8. Crack Orientation and Depth Estimation in a Low-Pressure Turbine Disc Using a Phased Array Ultrasonic Transducer and an Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    Wenshuang Chang

    2013-09-01

    Full Text Available Stress corrosion cracks (SCC in low-pressure steam turbine discs are serious hidden dangers to production safety in the power plants, and knowing the orientation and depth of the initial cracks is essential for the evaluation of the crack growth rate, propagation direction and working life of the turbine disc. In this paper, a method based on phased array ultrasonic transducer and artificial neural network (ANN, is proposed to estimate both the depth and orientation of initial cracks in the turbine discs. Echo signals from cracks with different depths and orientations were collected by a phased array ultrasonic transducer, and the feature vectors were extracted by wavelet packet, fractal technology and peak amplitude methods. The radial basis function (RBF neural network was investigated and used in this application. The final results demonstrated that the method presented was efficient in crack estimation tasks.

  9. Crack orientation and depth estimation in a low-pressure turbine disc using a phased array ultrasonic transducer and an artificial neural network.

    Science.gov (United States)

    Yang, Xiaoxia; Chen, Shili; Jin, Shijiu; Chang, Wenshuang

    2013-09-13

    Stress corrosion cracks (SCC) in low-pressure steam turbine discs are serious hidden dangers to production safety in the power plants, and knowing the orientation and depth of the initial cracks is essential for the evaluation of the crack growth rate, propagation direction and working life of the turbine disc. In this paper, a method based on phased array ultrasonic transducer and artificial neural network (ANN), is proposed to estimate both the depth and orientation of initial cracks in the turbine discs. Echo signals from cracks with different depths and orientations were collected by a phased array ultrasonic transducer, and the feature vectors were extracted by wavelet packet, fractal technology and peak amplitude methods. The radial basis function (RBF) neural network was investigated and used in this application. The final results demonstrated that the method presented was efficient in crack estimation tasks.

  10. 人工颈椎间盘的假体结构及应用特点%Prosthesis structure and application features of artificial cervical disc

    Institute of Scientific and Technical Information of China (English)

    颜端国

    2014-01-01

    背景:目前人工颈椎间盘假体设计和使用都得到了很大的发展,主要有低磨擦滑动面、弹簧系统、橡胶制成的人工颈椎间盘及其他各种弹性假体。目的:总结人工颈椎间盘假体结构特点及在骨科的应用现状。方法:由第一作者以“人工颈椎间盘;假体;椎间盘突出症”和“Artificial Cervical Disc;prosthesis;intervertebral disc herniation;the surgical therapy”为关键词,分别在CNKI(2000至2013年)和PubMed数据库(1960至2013年)http://www.ncbi.nlm.nih.gov/PubMed)检索近年文献,检索内容为人工颈椎间盘假体在骨科的应用。计算机在CNKI数据库检索出200篇文献,在PubMed数据库检索出56篇文献,阅读标题和进行筛选,保留符合纳入标准的40篇归纳总结。结果与结论:人工颈椎间盘假体类似椎间盘生理功能,材料具有耐磨损、耐疲劳、抗腐蚀等特点,它类似于人体椎间盘的生理和生物力学载荷功能,保持了脊柱的稳定和运动功能,避免了邻近节段的退变加速。文章重点对Bryan、Mobi-C、PCM、Prodisc-C、Prestige及CerviCore人工颈椎间盘结构做了介绍。人工颈椎间盘置换的短期疗效已得到认可,但是它不能完全替代颈前路植骨融合内固定,是治疗颈椎退变性椎间盘疾病的又一主要手段。%BACKGROUND:The design and use of artificial cervical disc prosthesis have great development, such as rubber-made artificial cervical disc with low-friction sliding surface and spring system, and other various elastic prostheses. OBJECTIVE:To summarize structural characteristics and present application of artificial cervical disc prosthesis. METHODS:The first author searched CNKI (2000-2013) and PubMed databases (1960-2013) http://www.ncbi.nlm.nih.gov/PubMed for literatures on application of artificial cervical disc prosthesis. The key words included artificial cervical disc, prosthesis, intervertebral disc

  11. Quality of systematic reviews: an example of studies comparing artificial disc replacement with fusion in the cervical spine.

    Science.gov (United States)

    Tashani, Osama A; El-Tumi, Hanan; Aneiba, Khaled

    2015-01-01

    Cervical artificial disc replacement (C-ADR) is now an alternative to anterior cervical discectomy and fusion (ACDF). Many studies have evaluated the efficacy of C-ADR compared with ACDF. This led to a series of systematic reviews and meta-analyses to evaluate the evidence of the superiority of one intervention against the other. The aim of the study presented here was to evaluate the quality of these reviews and meta-analyses. Medline via Ovid, Embase, and Cochrane Library were searched using the keywords: (total disk replacement, prosthesis, implantation, discectomy, and arthroplasty) AND (cervical vertebrae, cervical spine, and spine) AND (systematic reviews, reviews, and meta-analysis). Screening and data extraction were conducted by two reviewers independently. Two reviewers then assessed the quality of the selected reviews and meta-analysis using 11-item AMSTAR score which is a validated measurement tool to assess the methodological quality of systematic reviews. Screening of full reports of 46 relevant abstracts resulted in the selection of 15 systematic reviews and/or meta-analyses as eligible for this study. The two reviewers' inter-rater agreement level was high as indicated by kappa of >0.72. The AMSTAR score of the reviews ranged from 3 to 11. Only one study (a Cochrane review) scored 100% (AMSTAR 11). Five studies scored below (AMSTAR 5) indicating low-quality reviews. The most significant drawbacks of reviews of a score below 5 were not using an extensive search strategy, failure to use the scientific quality of the included studies appropriately in formulating a conclusion, not assessing publication bias, and not reporting the excluded studies. With a significant exception of a Cochrane review, the methodological quality of systematic reviews evaluating the evidence of C-ADR versus ACDF has to be improved.

  12. Discover人工颈椎间盘置换治疗颈椎间盘退变性疾病的临床疗效%Outcome of discover cervical artificial disc replacement for degenerativedisc disease of the cervical spine

    Institute of Scientific and Technical Information of China (English)

    何智勇; 李开南; 聂海; 母建松; 兰海

    2012-01-01

    Objective To estimate the clinical effects on Discover cervical artificial disc replacement for degenerative disc disease of the cervical spine. Methods A total of 20 patients with cervical disc degeneration, whose pain is not relieved adequately with six weeks of conservative care and daily activities become difficult, were chosed in this study between January 2007 and August 2011. The clinical outcomes were assessed using neck disable index (NDI) and visual analogue scale ( VAS) and Odora scale before surgery and 1、6、12、24 months after surgery. Imageological examination included X ray, cervical CT scanning and MR imaging. Results There are 26 levels in 20 patients performing cervical disc replacement and the follow-up period was 24 months. The NDI, VAS of neck pain, VAS of arm pain were from (23. 82 ±2. 87)、(5.90 ±0. 35)、(5. 91 ±1.63) before sugery to (5. 21 ± 1. 12)、(1. 62 ±0. 87)、(0. 97 ±0. 65) 2 years after sugery. Odom scale were excellent or good in all palienls. The operation time was 60-210 minutes and the estimated blood loss was 70 - 350 milliliter. The motion function of cervical artificial disc implanted was very good with imageology evaluation. The prosthesis moved forward 3 mm in one patient, and another patient had heterotopic ossification 12 months after surgery. Conclusion Discover cervical artificial disc replacement for degenerative disc disease of the cervical spine is safe and effective, however, further study should be conducted to determine the long term outcome.%目的 评价Discover人工颈椎间盘置换治疗颈椎间盘退变性疾病的临床疗效.方法 2007年1月~2011年8月,20例颈椎间盘退变突出经保守治疗无效的患者行人工颈椎间盘置换术.患者术前、术后1、6、12、24个月时使用颈椎功能障碍指数(neck disable index,NDI)、疼痛视觉模拟疼痛量表(visual analogue scale,VAS)进行疗效评估,手术效果采用Odom法评价.影像学检查包括颈椎动力位X

  13. The Effects of Disc Winds on the Spectrum and Black Hole Growth Rate of Active Galactic Nuclei

    OpenAIRE

    Slone, Oren; Netzer, Hagai

    2012-01-01

    Several properties of the standard alpha-disc model for active galactic nuclei (AGN) are not entirely consistent with AGN observations. As well as such discrepencies, observations show evidence for the existence of high mass outflow winds originating from the vicinity of the active black hole (BH). Such winds may originate from various parts of the disc and could change the local accretion rate which should alter the emitted spectral energy distribution (SED) and affect the global disc lumino...

  14. Construction of a tissue engineered intervertebral disc with high biological activity using an allogeneic intervertebral disc supplemented with transfected nucleus pulposus cells expressing exogenous dopamine beta-hydroxylase.

    Science.gov (United States)

    Bai, M; Wang, Y H; Yin, H P; Li, S W

    2015-09-09

    This study addressed the in vitro construction and biological activity of tissue engineered intervertebral discs with exogenous human dopamine beta-hydroxylase (DBH) nucleus pulposus cells. pSNAV2.0-DBH expression plasmids were utilized to enhance the survival rates of intervertebral disc tissue cells. Various concentrations of transfected nucleus pulposus cells were injected into the discs, and DBH mRNA expression was determined using polymerase chain reaction amplification. Polysaccharide content and total collagen protein content in the engineered disc nucleus pulposus tissue were determined. The visible fluorescence intensities of the 1 x 10(5) and 1 x 10(6) groups vs the 1 x 10(4) group were significantly increased (P 0.05) at 7 days after injection. DBH mRNA expression could be detected in the all but the EGFP control group at 14 days culture. No significant difference was observed in the protein content between the 1 x 10(4) and the control groups at various times, while the protein content was significantly higher in the 1 x 10(5) vs the control and the 1 x 10(4) groups at 7-, 14-, and 21-day cultures. These results demonstrate that a tissue engineered intervertebral disc with high biological activity can be constructed by utilizing allogeneic intervertebral discs stored in liquid nitrogen and a 1 x 10(5) transfected nucleus pulposus cell complex with in vitro culture for 14 days. This model can be used in animal experiments to study the biological activity of the engineered discs.

  15. Bulges and discs in the local Universe. Linking the galaxy structure to star formation activity

    Science.gov (United States)

    Morselli, L.; Popesso, P.; Erfanianfar, G.; Concas, A.

    2017-01-01

    We use a sample built on the SDSS DR7 catalogue and the bulge-disc decomposition of Simard et al. (2011, ApJS, 196, 11) to study how the bulge and disc components contribute to the parent galaxy's star formation activity, by determining its position in the star formation rate (SFR) - stellar mass (M⋆) plane at 0.02 age or metallicity content, suggesting different evolutionary paths for bulges on the MS and green valley with respect to those in the quiescence region. The disc g-r colour anti-correlates at any mass with the distance from the MS, getting redder when approaching the MS lower envelope and the quiescence region. The anti-correlation flattens as a function of the stellar mass, likely due to a higher level of dust obscuration in massive SF galaxies. We conclude that the position of a galaxy in the Log SFR - Log M⋆ plane depends on the star formation activity of its components: above the MS both bulge and disc are actively star forming. The nuclear activity is the first to be suppressed, moving the galaxies on the MS. Once the disc stops forming stars as well, the galaxy moves below the MS and eventually to the quiescence region. This is confirmed by a significant percentage ( 45%) of passive galaxies with a secure two component morphology, coexisting with a population of pure spheroidals. Our findings are qualitatively in agreement with the compaction-depletion scenario, in which subsequent phases of gas inflow in the centre of a galaxy and depletion due to high star formation activity move the galaxy across the MS before the final quenching episode takes place.

  16. Clinical and radiographic results of cervical artificial disc arthroplasty: over three years follow-up cohort study

    Institute of Scientific and Technical Information of China (English)

    TIAN Wei; HAN Xiao; LIU Bo; LI Qin; HU Lin; LI Zhi-yu; YUAN Qiang; HE Da; XING Yong-gang

    2010-01-01

    Background Theoretic advantages of cervical disc arthroplasty include preservation of normal motion and biomechanics in the cervical spine, and reduction of adjacent-segment degeneration. The clinical and radiographic effects of cervical disc arthroplasty in short term have been ascertained. The aim of this study is to research the data of mid-term results.Methods In this prospective cohort study, 50 patients who underwent cervical disc arthroplasty from December 2003 to January 2006 were enrolled. There were 39 patients who received 1-level disc arthroplasty, and 11 patients received 2-level disc arthroplasty, with an average age of 50.9 years (range from 29 to 73). The median follow-up was 41.85months (range from 36.00-55.63 months). Patients were followed prospectively with respect to their symptoms,neurologic signs, and radiographic results.Results The median value of Japanese Orthopaedic Association (JOA) score was 14.0 before surgery, and 16.5 at the most recent follow-up (P <0.01). The median value of the recovery rate of the JOA score was 92.2%. The preoperative range of motion (ROM) at the indexed level was (10.40±4.97)°, which has significantly correlated with the most recent follow-up ROM which was (8.56±4.76)° (P <0.05, r=0.33). The ROM at the operative level at the most recent follow-upwas greater than the value at the 3-month follow-up of (7.52±3.37)° (P <0.05). The preoperative functional spinal unit (FSU) angulation was (-0.96±6.52)°, which was not significantly correlated with that of the most recent follow-up value of (-2.65±7.95)° (P <0.01, r=0.53). The preoperative endplate angulation was (2.61±4.85)°, which had no significant correlation with that of the most recent follow-up value of (0.71±6.41)° (p >0.05).Conclusions The clinical and radiographic results of cervical disc arthroplasty are good in mid-term follow-up. The normal range of motion of the operated level and the biomechanics in the cervical spine are well

  17. Anisotropic radiation from accretion disc-coronae in active galactic nuclei

    CERN Document Server

    Xu, Ya-Di

    2015-01-01

    In the unification scheme of active galactic nuclei (AGN), Seyfert 1s and Seyfert 2s are intrinsically same, but they are viewed at different angles. However, the Fe K\\alpha emission line luminosity of Seyfert 1s was found in average to be about twice of that of Seyfert 2s at given X-ray continuum luminosity in the previous work (Ricci et al. 2014). We construct an accretion disc-corona model, in which a fraction of energy dissipated in the disc is extracted to heat the corona above the disc. The radiation transfer equation containing Compton scattering processes is an integro-differential equation, which is solved numerically for the corona with a parallel plane geometry. We find that the specific intensity of X-ray radiation from the corona changes little with the viewing angle \\theta when \\theta is small (nearly face-on), and it is sensitive to \\theta if the viewing angle is large (\\theta> 40 degrees). The radiation from the cold disc, mostly in infrared/optical/UV bands, is almost proportional to cos\\thet...

  18. Wear studies on ZrO2-filled PEEK as coating bearing materials for artificial cervical discs of Ti6Al4V.

    Science.gov (United States)

    Song, Jian; Liu, Yuhong; Liao, Zhenhua; Wang, Song; Tyagi, Rajnesh; Liu, Weiqiang

    2016-12-01

    Polyetheretherketone (PEEK) and its composite coatings are believed to be the potential candidates' bio-implant materials. However, these coatings have not yet been used on the surface of titanium-based orthopedics and joint products and very few investigations on the tribological characteristics could be found in the published literature till date. In this study, the wettabilities, composition and micro-hardness were characterized using contact angle measurement, scanning electron microscopy (SEM) and hardness tester. The tribological tests were conducted using a ball-on-disc contact pair under 25% newborn calf serum (NCS) lubricated condition. For comparison, bare Ti6Al4V was studied. The obtained results revealed that those PEEK/ZrO2 composite coatings could improve the tribological properties of Ti6Al4V significantly. Adhesive wear and mild abrasive wear might be the dominant wear and failure mechanisms for PEEK/ZrO2 composite coatings in NCS lubricated condition. After comprehensive evaluation in the present study, 5wt.% ZrO2 nanoparticles filled PEEK coating displayed the optimum tribological characteristics and could be taken as a potential candidate for the bearing material of artificial cervical disc.

  19. Metallocarbene Artificial Enzymes : Extending Transition Metal Selectivity and Protein Activity

    NARCIS (Netherlands)

    Basauri Molina, M.

    2015-01-01

    A series of new semi-synthetic metalloprotein hybrids were created via the covalent binding of organometallic species in the active site of lipases, accordingly resulting in the first active site-directed (ASD) homogeneous artificial metalloenzymes. The use of this method promises the generation of

  20. 人工颈椎间盘置换术治疗脊髓型颈椎病10例临床分析%Artificial cervical disc replacement in the treatment of cervical spondylotic myelopathy clinical analysis of 10 cases

    Institute of Scientific and Technical Information of China (English)

    杨磊; 崔宏勋; 赵庆安; 饶耀剑

    2013-01-01

      目的探讨人工颈椎间盘置换术用于治疗脊髓型颈椎病的临床疗效.方法2010年6月—2012年9月,对10例保守治疗无效患者的11个节段进行了人工颈椎间盘置换术,男6例,女4例;年龄41~61岁,平均(48±0.8)岁.单节段9例,双节段1例,术后随访3~12个月.结果所有患者伤口均I期临床愈合,术中及术后没有神经和血管损伤的并发症,结合术前术后颈椎活动范围检查、神经系统症状、Odom评级、JOA评分及影像学检查,患者神经系统症状均获得满意改善,JOA评分较术前明显升高.颈椎曲度、置换节段功能活动度、置换节段上下位椎体椎间隙高度得到保持.假体未见下沉或偏移,未见异位骨化.结论颈椎人工椎间盘置换术在维持节段运动功能的同时,可取得良好的神经减压效果,人工椎间盘置换术的短中期疗效是令人满意的.%Objective To investigate the artificial cervical disc replacement for the treatment of cervical spondylotic myelopathy. Methods In 2010 June to 2012 September,10 cases of invalid conservative treatment of patients with 11 segments for the artificial cervical disc replacement,6 cases were male,4 female;age 41-61 years,mean 48±0.8 years old. 9 cases of single segment,1 cases of double segments,followed up for 3 months to 12 months. Results All patients were healed wound phase I clinical,intraoperative and postoperative no nerve and blood vessel injury,combined examination of cervical range check, neurological symptoms,Odom rating,JOA score and imaging before and after surgery,patients with nervous system symptoms were satisfactory improvement,JOA score was significantly higher than that before operation. Cervical curvature,replacement of segmental function activity,replacement segment inferior vertebral height is maintained. Prosthesis no sinking or offset, no heterotopic ossification. Conclusion Cervical artificial disc replacement in the maintenance of segmental motion

  1. Clinical Effect of Anterior Disc Excision with Bone Graft Fusion and Bryan Artificial Cervical Disc Replacement%颈前路减压植骨融合与Bryan人工颈椎间盘置换疗效比较

    Institute of Scientific and Technical Information of China (English)

    陈昆; 蔡惠民; 陈荣滋

    2014-01-01

    目的:探讨颈椎前路减压植骨融合术( anterior cervical decompression and fusion,ACDF)与Bryan人工颈椎椎间盘置换术( artificial cervical disc replacement,ACDR)两种手术方式用于治疗脊髓型颈椎病及神经根型颈椎病的近期和远期疗效。方法系统分析我院2010年11月至2012年11月70例(70个节段)脊髓型或神经根型颈椎病患者病例资料,将70例(70个节段)脊髓型或神经根型颈椎病患者,通过随机数字表法随机分为ACDF组(35例)及Bryan组(35例)。通过分析术前及术后随访12个月的Odom′s标准评分、活动度( range of motion,ROM)、日本骨科协会( Japa-nese orthopaedic association,JOA)、健康调查简表( the MOS item short from health survey,SF-36)及颈椎残障功能指数( neck disability index,NDI)观察指标的差异,同时对随访12个月的上述各项指标进行两组间比较,比较两者疗效,分析两种术式的优点及他们产生的问题。结果两种手术方式都能取得明确疗效,治疗后患者症状明显缓解( P0.05);JOA评分及SF-36评分两者差异性不显著( P>0.05);而在12个月随访ROM评估及NDI比较有差异,Bryan组数据优于 ACDF组,差异具有统计学意义( P0. 05). JOA score and SF-36 scale had no significant differences(P>0. 05). There was difference between ROM and NDI in the evaluation of 12 month follow-up. Data of Bryan group were better than ACDF group(P<0. 05). Conclusion Bryan artificial cervical disc re-placement(ACDR)is superior to the anterior cervical decompression and fusion(ACDF)in reducing the adjacent segment degeneration of cervical vertebra. Its short-term and mid-term curative effect is superior to the ACDF. But Bryan artificial cervi-cal disc replacement( ACDR)coexist the complications such as incomplete decompression and heterotopic ossification,the long-term curative effect is inferior than ACDF.

  2. Contractile activity is required for Z-disc sarcomere maturation in vivo

    Science.gov (United States)

    Geach, Timothy J; Hirst, Elizabeth MA; Zimmerman, Lyle B

    2015-01-01

    Sarcomere structure underpins structural integrity, signaling, and force transmission in the muscle. In embryos of the frog Xenopus tropicalis, muscle contraction begins even while sarcomerogenesis is ongoing. To determine whether contractile activity plays a role in sarcomere formation in vivo, chemical tools were used to block acto-myosin contraction in embryos of the frog X. tropicalis, and Z-disc assembly was characterized in the paralyzed dicky ticker mutant. Confocal and ultrastructure analysis of paralyzed embryos showed delayed Z-disc formation and defects in thick filament organization. These results suggest a previously undescribed role for contractility in sarcomere maturation in vivo. genesis 53:299–307, 2015. © 2015 The Authors. Genesis Published by Wiley Periodicals, Inc. PMID:25845369

  3. Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety

    Directory of Open Access Journals (Sweden)

    J Mochida

    2015-03-01

    Full Text Available Degeneration of the lumbar intervertebral discs is irreversible, with no treatment currently available. Building upon experimental studies that demonstrated the importance of the nucleus pulposus (NP in preserving disc structure, we demonstrated that reinsertion of NP cells slowed further disc degeneration and that direct cell-to-cell contact co-culture with mesenchymal stromal cells (MSCs significantly upregulated the viability of NP cells in basic and pre-clinical studies in vitro and in vivo using animal models and human cells. Here, we report a 3-year result of a prospective clinical study, aimed to assess the safety and efficacy of activated NP cell transplantation in the degenerate lumbar intervertebral disc. Candidates were 9 patients aged 20-29 years who had Pfirrmann’s grade III disc degeneration at the level adjacent to the level scheduled for posterior lumbar intervertebral fusion. Viable NP cells from the fused disc were co-cultured in direct contact with autologous bone marrow-derived MSCs. One million activated NP cells were transplanted into the degenerated disc adjacent to the fused level at 7 d after the first fusion surgery. No adverse effects were observed during the 3-year follow-up period. Magnetic resonance imaging did not show any detrimental effects to the transplanted discs and revealed a mild improvement in 1 case. No cases reported any low back pain. Our clinical study confirmed the safety of activated NP cell transplantation, and the findings suggest the minimal efficacy of this treatment to slow the further degeneration of human intervertebral discs.

  4. A Bayesian framework for active artificial perception.

    Science.gov (United States)

    Ferreira, João Filipe; Lobo, Jorge; Bessière, Pierre; Castelo-Branco, Miguel; Dias, Jorge

    2013-04-01

    In this paper, we present a Bayesian framework for the active multimodal perception of 3-D structure and motion. The design of this framework finds its inspiration in the role of the dorsal perceptual pathway of the human brain. Its composing models build upon a common egocentric spatial configuration that is naturally fitting for the integration of readings from multiple sensors using a Bayesian approach. In the process, we will contribute with efficient and robust probabilistic solutions for cyclopean geometry-based stereovision and auditory perception based only on binaural cues, modeled using a consistent formalization that allows their hierarchical use as building blocks for the multimodal sensor fusion framework. We will explicitly or implicitly address the most important challenges of sensor fusion using this framework, for vision, audition, and vestibular sensing. Moreover, interaction and navigation require maximal awareness of spatial surroundings, which, in turn, is obtained through active attentional and behavioral exploration of the environment. The computational models described in this paper will support the construction of a simultaneously flexible and powerful robotic implementation of multimodal active perception to be used in real-world applications, such as human-machine interaction or mobile robot navigation.

  5. The Developing of Meaningful Activity in Artificial Environment

    DEFF Research Database (Denmark)

    Holsbæk, Jonas

    developing. Results/Discussion: Data from the observation suggested that the moch up could support the participants with Dementia in experiencing flow, and that the physical activity was experienced as meaningful for the participants. Conclusion: An artificial environment can support the experience of Flow......Abstract: The Developing of Meaningful Activity in Artificial Environment Subtheme: Innovations and Challenges in Occupational Therapy Category: Live stage: Elderly Area of Practice: Technology and Medical Science Keywords: Innovations and challenges, Occupational balance Introduction: Due...... is Ambient Assisted Living (ALL). ALL is often focused on the institutional and societal needs (saving man power eg.) as primary objectives, and the user needs as secondary. Physical activity as well as meaningful activity and experience of Flow, has a positive influence on health for all humans...

  6. Application of finite element analysis in a biomechanical study on artificial lumbar disc%有限元分析在腰椎人工椎间盘生物力学研究中的应用

    Institute of Scientific and Technical Information of China (English)

    陈小龙; 海涌; 关立; 刘玉增

    2015-01-01

    Lumbar disc herniation is one of the major causes of chronic low back pain. Fusion surgery is the gold standard in surgical treatment of the disease, while adjacent segment degeneration is often resulted from the fusion surgery. In order to keep normal motion of the disc, artiifcial disc replacement has been put forward. In the past 50 years, the technology has developed from basic research and animal experiment stage to clinical application stage, which has become a routine treatment option for chronic low back pain. In recent 20 years, there has been many clinical and biomechanical research reports at home and abroad. Along with the advance of the technology, finite element method has been increasingly used in the biomechanical study on artificial lumbar disc. A large number of studies show that the clinical outcomes of disc prostheses are good, while the design and application of artiifcial intervertebral disc remain to be improved. By using three-dimensional ( 3 D ) ifnite element method, the mechanical properties can be obtained through the simulated body condition and simple physical experiment of artiifcialdisc prostheses, so as to reflect the mechanical changes of artificial disc in the process of physiological and pathological processes. The ifnite elementmethod can be used to analyze the stress and strain of components with complex morphology, structure, material and loading condition, with the advantages of comprehensive mechanical properties, repeatability, high-level controllability, etc. In this paper, the characteristics of several kinds of commonly used ifnite element analysis softwares are introduced, and the research results of ifnite elementmethod in artiifcial disc replacement and the effects of artiifcial disc implantation on spinal biomechanics are summarized. When compared with in vitro experiment, the finite element method has its own advantages and disadvantages. It is thought that more meaningful results can be achieved through the

  7. 单节段颈椎人工椎间盘置换术临床疗效探讨%Clinical study of single-level artificial cervical disc replacement for cervical spondylosis

    Institute of Scientific and Technical Information of China (English)

    戚正; 王利民; 谭洪宇; 王卫东

    2011-01-01

    Objective To investigate the curative effect of single-level artifical cervical disc arthroplasty. Methods Thirty-two patients with cervical spondylosis were treated with single-level artifical cervical disc replacement, At 6 weeks, 3, 6, 12 and 18 months after operation, the patients were followed up. The radiography of forward flexion, backward extension, and left and right lateral flexion were obtained atevery follow-up time. The stability of prosthesis, the range of motion status atoperated levelin Active C group were observed. Meanwhile, investigate all patients with complications by follow-up score. Results The incidence rates of early postoperative dysphagia,cervicodynia,brachialgia in the operation group decreased obviously(P<0.05).There was no significant difference in the motion range of adjancent segments before and after Active C replacement(P>0.05). Conclusions Single segment cervial artificial disc replacement can reduce complications in early stage. The adjacent segments postoperative is avoided in mid-term.%目的 探讨单节段颈椎人工椎间盘置换术临床疗效.方法 对我院32例患者经单节段颈椎人工椎间盘(ActivC型)置换术.术后6周、3个月、6个月、12个月、18个月复查拍摄颈椎前屈后伸动力位X线片,观察置换组假体稳定性.同时进行术后系列调查评分,对治疗结果进行回顾性分析.结果 手术组术后早期吞咽困难、颈痛、上肢疼痛等发生率明显降低(P<0.05).人工颈椎间盘置换组置换前后邻近节段活动范围差异无统计学意义(P>0.05).结论 单节段颈椎人工椎间盘置换术后早期并发症减少,中期能保护相邻节段退变.

  8. Activated sludge process based on artificial neural network

    Institute of Scientific and Technical Information of China (English)

    张文艺; 蔡建安

    2002-01-01

    Considering the difficulty of creating water quality model for activated sludge system, a typical BP artificial neural network model has been established to simulate the operation of a waste water treatment facilities. The comparison of prediction results with the on-spot measurements shows the model, the model is accurate and this model can also be used to realize intelligentized on-line control of the wastewater processing process.

  9. The Effects of Disc Winds on the Spectrum and Black Hole Growth Rate of Active Galactic Nuclei

    CERN Document Server

    Slone, Oren

    2012-01-01

    Several properties of the standard alpha-disc model for active galactic nuclei (AGN) are not entirely consistent with AGN observations. As well as such discrepencies, observations show evidence for the existence of high mass outflow winds originating from the vicinity of the active black hole (BH). Such winds may originate from various parts of the disc and could change the local accretion rate which should alter the emitted spectral energy distribution (SED) and affect the global disc luminosity and the BH growth rate. The new calculations presented here show the effects of several types of winds on the observed and inferred disc properties. Some wind profiles can have a profound effect on the observed SED and can perhaps explain the poorly understood deviations of AGN spectra from standard disc spectra. We show a factor ~2 possible error in estimating the disc luminosity and larger deviations in estimating L/Ledd. The BH growth rate computed without taking the effects of wind into account may be significant...

  10. Catalytically active nanomaterials: a promising candidate for artificial enzymes.

    Science.gov (United States)

    Lin, Youhui; Ren, Jinsong; Qu, Xiaogang

    2014-04-15

    Natural enzymes, exquisite biocatalysts mediating every biological process in living organisms, are able to accelerate the rate of chemical reactions up to 10(19) times for specific substrates and reactions. However, the practical application of enzymes is often hampered by their intrinsic drawbacks, such as low operational stability, sensitivity of catalytic activity to environmental conditions, and high costs in preparation and purification. Therefore, the discovery and development of artificial enzymes is highly desired. Recently, the merging of nanotechnology with biology has ignited extensive research efforts for designing functional nanomaterials that exhibit various properties intrinsic to enzymes. As a promising candidate for artificial enzymes, catalytically active nanomaterials (nanozymes) show several advantages over natural enzymes, such as controlled synthesis in low cost, tunability in catalytic activities, as well as high stability against stringent conditions. In this Account, we focus on our recent progress in exploring and constructing such nanoparticulate artificial enzymes, including graphene oxide, graphene-hemin nanocomposites, carbon nanotubes, carbon nanodots, mesoporous silica-encapsulated gold nanoparticles, gold nanoclusters, and nanoceria. According to their structural characteristics, these enzyme mimics are categorized into three classes: carbon-, metal-, and metal-oxide-based nanomaterials. We aim to highlight the important role of catalytic nanomaterials in the fields of biomimetics. First, we provide a practical introduction to the identification of these nanozymes, the source of the enzyme-like activities, and the enhancement of activities via rational design and engineering. Then we briefly describe new or enhanced applications of certain nanozymes in biomedical diagnosis, environmental monitoring, and therapeutics. For instance, we have successfully used these biomimetic catalysts as colorimetric probes for the detection of

  11. Magnetically elevated accretion discs in active galactic nuclei: broad emission-line regions and associated star formation

    Science.gov (United States)

    Begelman, Mitchell C.; Silk, Joseph

    2017-01-01

    We propose that the accretion discs fueling active galactic nuclei (AGN) are supported vertically against gravity by a strong toroidal (φ-direction) magnetic field that develops naturally as the result of an accretion disc dynamo. The magnetic pressure elevates most of the gas carrying the accretion flow at R to large heights z ≳ 0.1R and low densities, while leaving a thin dense layer containing most of the mass - but contributing very little accretion - around the equator. We show that such a disc model leads naturally to the formation of a broad emission-line region through thermal instability. Extrapolating to larger radii, we demonstrate that local gravitational instability and associated star formation are strongly suppressed compared to standard disc models for AGN, although star formation in the equatorial zone is predicted for sufficiently high mass supply rates. This new class of accretion disc models thus appears capable of resolving two longstanding puzzles in the theory of AGN fueling: the formation of broad emission-line regions and the suppression of fragmentation thought to inhibit accretion at the required rates. We show that the disc of stars that formed in the Galactic Center a few million years ago could have resulted from an episode of magnetically elevated accretion at ≳ 0.1 of the Eddington limit.

  12. 人工颈椎间盘结构、材料及体外生物力学的研究进展*★%Research progresses of artificial cervical disc structure, material and in vitro biomechanics

    Institute of Scientific and Technical Information of China (English)

    蒲婷; 原芳; 廖振华; 刘伟强

    2013-01-01

      背景:人工颈椎间盘置换作为颈椎疾病治疗的全新方法,正逐渐得到临床广泛认可,其使用的植入器械——人工颈椎间盘还需更深入研发及验证。目的:综述了现有人工颈椎间盘产品的结构、材料及体外生物力学研究,并对未来发展状态进行展望。方法:以“artificial cervical disc,prothesis,structure,material,biomechanical study”为英文检索词检索Pubmed数据库,以“人工颈椎间盘,假体,结构,材料,生物力学”为检索词检索CNKI数据库,纳入人工颈椎间盘结构设计、材料设计及体外生物力学评估相关工作,主要整理近5年来有关研究,排除重复性工作,重点对36篇文献进行分析讨论。结果与结论:现有人工颈椎间盘产品主要采用金属-聚合物(MOP)结构,以半限制型和非限制型居多,尺寸系列已较完善,且全为进口产品。通过对现有产品进行分析与总结,提出人工颈椎间盘在新结构设计、面向种群设计和材料改进3个方向有重大发展空间,材料改进可以从终板材料、髓核材料、表面喷涂材料几方面考虑。%  BACKGROUND: Artificial cervical disc replacement has been widely used in clinical cervical surgery. Further research of biomechanics of the artificial cervical disc used in the surgery is needed. OBJECTIVE: To review the structure, material types and in vitro biomechanical study of the existed artificial cervical disc, and to prospect the development in the future. METHODS: The PubMed databases and CNKI database were searched with key words of “artificial cervical disc, prosthesis, structure, material, biomechanical study” in English and Chinese respectively. The articles related to artificial cervical disc structure, material, and in vitro biomechanics were included. The researches in the recent 5 years were col ected, and the repetitive studies were excluded. A total of 36

  13. Clumpy tori illuminated by the anisotropic radiation of accretion discs in active galactic nuclei

    CERN Document Server

    He, Jian-Jian; Zhang, Shuang-Nan

    2015-01-01

    In this paper, we try to explain the observed correlation between the covering factor (CF) of hot dust and the properties of active galactic nuclei (AGNs), e.g., the bolometric luminosity ($L_{\\rm{bol}}$) and black hole mass ($M_{\\rm{BH}}$). Combining the possible dust distribution in the torus, the angular dependence of the radiation of the accretion disc, and the relation between the critical angle of torus and the Eddington ratio, there are eight possible models investigated in our work. We fit the observed CF with these models to determine the parameters of them. As a result, clumpy torus models can generally explain the observed correlations of tori, while the smooth models fail to produce the required CFs. However, there is still significant scatter even for the best-fitting model, which is the combination of a clumpy torus illuminated by the anisotropic radiation of accretion disc in an AGN. Although some of the observed scatter is due to the uncertainties in measuring $L_{\\rm{bol}}$ and $M_{\\rm{BH}}$,...

  14. Degenerative disc disease in the lumbar spine: Another cause for focally reduced activity on marrow scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, M. (Addenbrookes Hospital, Cambridge (United Kingdom). Dept. of Radiology); Miles, K.A. (Addenbrookes Hospital, Cambridge (United Kingdom). Dept. of Radiology Addenbrookes Hospital, Cambridge (United Kingdom). Dept. of Nuclear Medicine); Wraight, E.P. (Addenbrookes Hospital, Cambridge (United Kingdom). Dept. of Nuclear Medicine); Dixon, A.K. (Addenbrookes Hospital, Cambridge (United Kingdom). Dept. of Radiology Cambridge Univ. (United Kingdom))

    1992-05-01

    A patient is presented in whom a focal reduction in marrow activity in the lumbar spine on both leucocyte and nanocolloid marrow scintigraphy was subsequently shown to be due to fatty infiltration of marrow in association with disc degeneration. Degenerative disease in the lumbar spine has not been previously described as a cause of abnormal bone marrow distribution by such means and needs to be distinguished from a more serious pathology, such as malignant infiltration and vertebral infection, which it may mimic. In a retrospective review of 33 nanocolloid bone marrow and 117 leucocyte scintigrams, 8 showed a degree of reduced marrow activity in the lumbar spine consistent with that caused by degenerative changes. (orig.).

  15. Finite element analysis of cervical spine following artificial intervertebral disc replacement%颈椎人工椎间盘置换有限元分析

    Institute of Scientific and Technical Information of China (English)

    徐波; 金大地; 张美超

    2013-01-01

    Objective To establish a three-dimensional finite element model of cervical spine C4~5segment following PrestigeTM-LP artificial intervertebral disc replacement and analyze segmental motions.Methods The geometry of C4~5 vertebrae was reconstructed from computer tomography (CT) scan images of an adult male human fresh cervical spinal specimen.A FEM of C4~5 vertebrae and PrestigeTM-LP prosthesis was established and simulated clinical operation by using ANSYS10.0 system.Motions of flexion,extension,lateral bending and axial rotation were determined in physiological loading.Results Detailed geometries of vertebral bodies were modeled including ligaments,facet joints,and uncovertebral joints.Motions of flexion,extension,lateral bending,axial rotation are 5.7°,3.5°,5.0°,11.3°,respectively and conform with what have been reported in the literature.Conclusions The FEM possesses a high precision of geometries of vertebral bodies and biomechanical character.PrestigeTM-LP artificial disc prosthesis well preserves intervertebral segmental motion for cervical spine.%目的 建立C4~5节段PrestigeTM-LP颈椎人工椎间盘植入后的三维有限元模型,进行手术节段的运动分析.方法 采用对成年男性的新鲜尸体的颈椎标本进行CT三维扫描方法建立C4~5节段和PrestigeTM-LP人工间盘有限元,模拟完成C4~5人工椎间盘置换手术.测量生理加载下手术节段前屈/后伸、侧弯及轴向旋转运动角度.结果 有限元模型对颈椎的结构,包括椎体间韧带、颈椎关节突关节、钩椎关节等均进行了精确的重建,并较好地模拟手术操作进行PrestigeTM-LP人工间盘植入.运动加载后运动角度,前屈5.7°,后伸3.5°,侧弯5.0°,旋转11.3°,与文献报道结果较为接近.结论 有限元模型具有精确度高,手术模拟真实的特点,可作为颈椎人工椎间盘生物力学研究的一种较好途径.PrestigeTM-LP颈椎人工椎间盘置换可较好地保留手术节段的运动功能.

  16. Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis.

    Science.gov (United States)

    Jeong, Claire G; Francisco, Aubrey T; Niu, Zhenbin; Mancino, Robert L; Craig, Stephen L; Setton, Lori A

    2014-08-01

    Hyaluronic acid (HA)-poly(ethylene glycol) (PEG) composite hydrogels have been widely studied for both cell delivery and soft tissue regeneration applications. A very broad range of physical and biological properties have been engineered into HA-PEG hydrogels that may differentially affect cellular "outcomes" of survival, synthesis and metabolism. The objective of this study was to rapidly screen multiple HA-PEG composite hydrogel formulations for an effect on matrix synthesis and behaviors of nucleus pulposus (NP) and annulus fibrosus (AF) cells of the intervertebral disc (IVD). A secondary objective was to apply artificial neural network analysis to identify relationships between HA-PEG composite hydrogel formulation parameters and biological outcome measures for each cell type of the IVD. Eight different hydrogels were developed from preparations of thiolated HA (HA-SH) and PEG vinylsulfone (PEG-VS) macromers, and used as substrates for NP and AF cell culture in vitro. Hydrogel mechanical properties ranged from 70 to 489kPa depending on HA molecular weight, and measures of matrix synthesis, metabolite consumption and production and cell morphology were obtained to study relationships to hydrogel parameters. Results showed that NP and AF cell numbers were highest upon the HA-PEG hydrogels formed from the lower-molecular-weight HA, with evidence of higher sulfated glycosaminoglycan production also upon lower-HA-molecular-weight composite gels. All cells formed more multi-cell clusters upon any HA-PEG composite hydrogel as compared to gelatin substrates. Formulations were clustered into neurons based largely on their HA molecular weight, with few effects of PEG molecular weight observed on any measured parameters.

  17. 推拿配合人工牵拉闪压腰法及针刺治疗腰椎间盘突出症%Massage Combined with Artificial Traction Flash Press Waist Method and Acupuncture Treating Lumbar Disc Herniation

    Institute of Scientific and Technical Information of China (English)

    黄利云; 张胜良; 靳伟跃; 杨粉霞; 张志文

    2013-01-01

    目的:探讨中医治疗腰椎间盘突出症的创新方法。方法:152例腰椎间盘突出症患者应用推拿手法及人工牵拉瞬间闪压相应椎旁痛点,并配合针刺治疗。结果:治愈81例,显效35例,好转25例,无效11例,总有效率为92.76%。结论:推拿配合人工牵拉闪压腰法及针刺治疗腰椎盘突出症安全有效,无毒副作用,患者易于接受。%Objective:To explore the innovative methods of traditional Chinese medicine treating lumbar disc herniation. Methods:152 cases of lum-bar disc herniation were applied with massage combined with artificial traction flash pressing corresponding paravertebral point of pain and acupunc-ture. Results:81 cases were cured, 35 cases markedly effective, 25 cases improved, 11 cases ineffective, the total effective rate was 92.76%. Conclu-sion:Massage combined with artificial traction flash press waist method and acupuncture treating lumbar disc herniation is safe and effective, with-out toxic and side effects, easily accepted by patients.

  18. Film analysis of activated sludge microbial discs by the Taguchi method and grey relational analysis.

    Science.gov (United States)

    Chen, M Y; Syu, M J

    2003-12-01

    A biofilm model with substrate inhibition is proposed for the activated sludge growing discs of rotating biological contactor (RBC); this model is different from the steady-state biofilm model based on the Monod assumption. Both deep and shallow types of biofilms are examined and discussed. The biofilm models based on both Monod and substrate inhibition (Haldane) assumptions are compared. In addition, the relationships between substrate utilization rate, biofilm thickness, and liquid phase substrate concentration are discussed. The influence order of the factors that affect the biofilm thickness is studied and discussed by combining the Taguchi method and grey relational analysis. In this work, a Taguchi orthogonal table is used to construct the series that is needed for grey relational analysis to determine the influence priority of the four parameters S(B), kX(f), K(s), and K(i).

  19. Effects of Ge Gen Decoction on PGE2 Content and COX Activity in the Degenarated Cervical Intervertebral Discs of Rats

    Institute of Scientific and Technical Information of China (English)

    Zhou Jun; Fang Suping; Huo Hairu; Qi Yun; Guo Shuying; Jiang Tingliang; Shi Qi; Wang Youjing

    2005-01-01

    After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay.The results indicated that the PGF2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treating cervical spondylosis.

  20. The jet-disc connection: evidence for a reinterpretation in radio loud and radio quiet active galactic nuclei

    CERN Document Server

    Garofalo, David

    2013-01-01

    To constrain models of the jet-disc connection, we explore Eddington ratios reported in Foschini (2011) and interpret them in relation to the values in Sikora et al. across the active galactic nuclei population from radio loud quasars, their flat spectrum radio quasar subclass, the recently discovered gamma-ray loud narrow-line type 1 Seyfert galaxies, Fanaroff-Riley type I (FRI) radio galaxies and radio quiet quasars of the Palomar Green survey. While appeal to disc truncation in radiatively inefficient flow appears to explain the observed inverse relation between radio loudness and Eddington ratio in radio loud and radio quiet quasars, FR I objects, scale invariance and recent data on powerful jets in narrow-line Seyfert 1 galaxies offer compelling arguments in favour of a reinterpretaion of the jet-disc connection.

  1. Line and continuum emission from the outer regions of accretion discs in active galactic nuclei. V. Detailed computational results

    Energy Technology Data Exchange (ETDEWEB)

    Dumont, A.M. (Observatoire de Paris, Section de Meudon, 92 (FR)); Collin-Souffrin, S. (Centre National de la Recherche Scientifique, 75 - Paris (FR). Inst. d' Astrophysique)

    1990-04-01

    This paper completes the results concerning the structure of the outer regions of accretion discs in Active Galactic Nuclei, and of their line emission spectra (profiles and line intensities). The computational method has been described in a series of previous papers.

  2. Line-driven disc wind model for ultrafast outflows in active galactic nuclei - scaling with luminosity

    Science.gov (United States)

    Nomura, M.; Ohsuga, K.

    2017-03-01

    In order to reveal the origin of the ultrafast outflows (UFOs) that are frequently observed in active galactic nuclei (AGNs), we perform two-dimensional radiation hydrodynamics simulations of the line-driven disc winds, which are accelerated by the radiation force due to the spectral lines. The line-driven winds are successfully launched for the range of MBH = 106-9 M⊙ and ε = 0.1-0.5, and the resulting mass outflow rate (dot{M_w}), momentum flux (dot{p_w}), and kinetic luminosity (dot{E_w}) are in the region containing 90 per cent of the posterior probability distribution in the dot{M}_w-Lbol plane, dot{p}_w-Lbol plane, and dot{E}_w-Lbol plane shown in Gofford et al., where MBH is the black hole mass, ε is the Eddington ratio, and Lbol is the bolometric luminosity. The best-fitting relations in Gofford et al., d log dot{M_w}/d log {L_bol}˜ 0.9, d log dot{p_w}/d log {L_bol}˜ 1.2, and d log dot{E_w}/d log {L_bol}˜ 1.5, are roughly consistent with our results, d log dot{M_w}/d log {L_bol}˜ 9/8, d log dot{p_w}/d log {L_bol}˜ 10/8, and d log dot{E_w}/d log {L_bol}˜ 11/8. In addition, our model predicts that no UFO features are detected for the AGNs with ε ≲ 0.01, since the winds do not appear. Also, only AGNs with MBH ≲ 108 M⊙ exhibit the UFOs when ε ∼ 0.025. These predictions nicely agree with the X-ray observations. These results support that the line-driven disc wind is the origin of the UFOs.

  3. Design principle and development tendency of artificial lumbar disc prosthesis%人工腰椎间盘假体设计原理研究及未来趋势发展

    Institute of Scientific and Technical Information of China (English)

    董可欣; 马德春; 李秋菊; 张丽; 李磊

    2014-01-01

    BACKGROUND:Artificial lumbar disc replacement is a new choice for the treatment of degenerative disc disease, and preserves lumbar vertebra’s biomechanical characteristics during pain elimination. The design of the prosthesis structure and material needs further study and validation. OBJECTIVE:To review the structure and material types of presently designed artificial lumbar discs, then to discuss the trends in the optimization design of prosthesis. METHODS:The PubMed database, China National Knowledge Infrastructure database and Chinese BioMedical Literature Database were searched for related articles concerning artificial lumbar disc and type and biomechanics of nucleus pulposus prosthesis material published from January 2005 to February 2013 by the first author. Key words were“artificial lumbar disc, principle of prosthesis design, structure, material, clinical trials”in Chinese and“artificial lumbar disc, total disc replacement, structure, material, clinical trial”in English. Repetitive and old studies were excluded. 135 articles were found, but 36 articles were included for review. RESULTS AND CONCLUSION:At present, the materials for intervertebral discs include cobalt-chromium al oy, ceramics, stainless steel, titanium al oy and ultrahigh molecular weight polyethylene. Artificial lumbar disc is commonly made by different materials. Bryan prosthesis is most commonly used in the clinic. Three-dimensional finite element analysis, in vitro trial and clinical studies verified its good biomechanical property. The successful rate of replacement was high. Nucleus prosthesis contains prefabricated type and situ polymerization type, and obtains smal injury, so it is a hot focus in present study, but it cannot achieve biomechanical function of human nucleus pulposus. To dig novel material is a future direction for designing individual prosthesis. The prosthetic structure and biomaterial design experience constant improvement and development. This study

  4. PRELIMINARY CLINICAL STUDY ON ARTIFICIAL CERVICAL DISC REPLACEMENT BY Mobi-C PROSTHESIS%Mobi-C人工颈椎间盘临床应用初步报告

    Institute of Scientific and Technical Information of China (English)

    鲍达; 马远征; 陈兴; 李宏伟; 胡明; 高天君

    2011-01-01

    Objective To study the clinical application of Mobi-C prosthesis in treatment of anterior cervical discectomy and artificial disc replacement (ADR). Methods Between January 2009 and June 2009, 20 cases of degenerative cervical disease were treated with anterior discectomy and ADR by Mobi-C prosthesis, including 13 cases of cervical disc herniation and 7 cases of cervical spondylotic radiculopathy, and 25 Mobi-C prosthesis were implanted. There were 8 males and 12 females, aged 29-54 years (mean, 45.2 years). The disease duration was from 4 days to 5 years (mean, 1.2 years). Affected segments of process included C3, 4 in 1 case, C4, 5 in 2 cases, C5, 6 in 7 cases, C6,7 in 5 cases, C4, 5 and C5, 6 in 2 cases, and C5, 6 and C6, 7 in 3 cases. Radiographs were taken regularly, and cervical range of motion (ROM) on segments of disc replacements were measured. The functions of cervical spinal cord were evaluated by "40 score" system (COA) preoperatively, immediately postoperatively, and at follow-up. The quality of life was evaluated by neck disability index (NDI) and visual analogue scale (VAS) score. Results All incisions healed by first intention. No perioperative complication was found. All cases were followed up 16.5 months on average (range, 14-18 months). There was no significant difference in cervical ROM of operatied segment between preoperation and follow-up duration (t=0.808, P=0.440). No heterotopic ossification was found at follow-up. COA score at last follow-up (38.20 ± 1.14) was significantly higher than preoperative one (32.10 ± 2.96), (t=9.278, P=0.000), and the improvement rate at last follow-up was 77.2% ± 5.4%. VAS score at last follow-up (3.20 ± 1.23) had significant difference when compared with preoperative one (5.10 ± 1.29), (t=10.585, P=0.000). NDI score at last follow-up (29.40 ± 4.55) had significant difference when compared with preoperative one (39.20 ± 3.80), (t=16.039, P=0.000). Conclusion A satisfactory short-term curative effect

  5. Retrospective analysis of multi-level cervical artificial disc replacement compared with nearby segments fused for multi-level disc hernations%人工椎间盘置换与颈前路融合治疗多节段颈椎病回顾性分析

    Institute of Scientific and Technical Information of China (English)

    王衡; 刘英杰; 常江; 张锴; 朱卉敏

    2015-01-01

    目的 对比总结多节段颈椎间盘突出症患者分别实施人工椎间盘置换和颈前路融合固定的效果分析,判断人工椎间盘置换术后效果.方法 自2005年7月对16例多节段颈椎间盘突出患者进行了前路椎间盘切除、Bryan人工椎间盘置换术(A组),观察手术前后VAS评分及颈椎活动度变化,并与同期所做的多节段颈前路融合内固定23例患者(B组)相对照.结果 两组患者术后各时间点疼痛缓解、VAS评分较术前有明显提高(P<0.05),术后两组VAS评分比较差异未见统计学意义(P>0.05).术后12个月及2年时两组间整体活动度比较差异有统计学意义(P<0.05),A组人工椎间盘置换节段术后2年活动度与术前比较差异未见统计学意义(P>0.05).A组末次随访时较术后3d时显著增加(P<0.05);B组术后各时间点比较差异未见统计学意义(P>0.05).结论 人工椎间盘置换治疗多节段颈椎间盘突出症临床效果较好,术后对手术节段的活动度影响较小,是一种解决颈椎活动性与稳定性矛盾的较好的方法.%Objective To evaluate the therapeutic effects of the multi-level cervical artificial disc replacements compared with the anterial cervical artificial fusion on the multi-level disc fusion and to investigate their effect after the treatment.Methods The patient with discectomy underwent cervical artificial disc replacements (group A) in the C3-7 intervertebral discs from July.2005.The VAS score and the range of motion(ROM) of two groups was observed perioperatively.Results The patient could move his neck in all directions without pain.The spinal and neural symptoms were significantly alleviated,and there were obviously elevation in VAS score in each time point (P < 0.05),and there was no significant difference in VAS score between the two groups (P < 0.05).There were significant differences in the range of motion(ROM) of two groups according to the follow-up for 12 month and 2

  6. Functional evaluation of the cervical spine after Bryan artificial disc replacement%Bryan人工颈椎间盘置换对颈椎功能影响的临床分析

    Institute of Scientific and Technical Information of China (English)

    田伟; 刘波; 李勤; 胡临; 李志宇; 袁强; 韩骁

    2008-01-01

    Objective To assess the effect of Bryan cervical disc replacement on the function of the cervical spine.Methods Bryan cervical artificial disc replacement was performed in 164 cases from Dec 2003 to Aug 2007,and all the cases were retrospectively followed up.Among them,1 disc replacement was done in 132 cases,2 discs in 28 cases and 3 discs in 4 eases with a total number of 200 artificial discs. There were 102 male patients and 62 female patients.Their age ranged from 25 to 70 years old(with an average of 47 years old).All the cases were operated according to the standard procedure for Bryan artificial disc replacement,and immobilized in a cervical collar for 2 weeks after operation.Motion of the replaced disc in sagittal direction,JOA score and satisfaction rate of the patients were followed up and evaluated.Results In this group,no acute complications happened during the operation.All patients returned to work 4 to 6 weeks after operation.The postoperative ameliorate rate of JOA score was 56%. Range of motion in sagittal direction of the operated disc was 14.4 degrees before operation,decreased to 5.7 degrees at 1 week after operation,but improved to 14.7 degrees at the time of final follow-up and was not significantly different from preoperative range.Motion in the upper adjacent disc to the replacement level was 10.9 degrees before operation,decreased to 5.5 degrees at 1 week after operation,and improved to 8.2 degees at the time of final follow-up but was significantly smaller than preoperative range.The satisfaction rate of the patients was 94%.Loosening of the prosthesis happened in 1 case 6 months after operation but remained stable afterwards.Subsidence up to 1 mm occurred in another case 7 months after operation but also remained stable afterwards.Automatic posterior union occurred in 3 cases in which relative small size artificial discs were implanted.Conclusions The clinical outcome of Bryan artificial disc replacement was quite

  7. Active galactic nuclei at z ~ 1.5: I. Spectral energy distribution and accretion discs

    CERN Document Server

    Capellupo, Daniel M; Lira, Paulina; Trakhtenbrot, Benny; Mejía-Restrepo, Julían

    2014-01-01

    The physics of active super massive black holes (BHs) is governed by their mass (M_BH), spin (a*) and accretion rate ($\\dot{M}$). This work is the first in a series of papers with the aim of testing how these parameters determine the observable attributes of active galactic nuclei (AGN). We have selected a sample in a narrow redshift range, centered on z~1.55, that covers a wide range in M_BH and $\\dot{M}$, and are observing them with X-shooter, covering rest wavelengths ~1200-9800 \\AA. The current work covers 30 such objects and focuses on the origin of the AGN spectral energy distribution (SED). After estimating M_BH and $\\dot{M}$ based on each observed SED, we use thin AD models and a Bayesian analysis to fit the observed SEDs in our sample. We are able to fit 22/30 of the SEDs. Out of the remaining 8 SEDs, 3 can be fit by the thin AD model by correcting the observed SED for reddening within the host galaxy and 4 can be fit by adding a disc wind to the model. In four of these 8 sources, Milky Way-type exti...

  8. Photochemical chlorine and bromine activation from artificial saline snow

    Directory of Open Access Journals (Sweden)

    S. N. Wren

    2013-05-01

    Full Text Available The activation of reactive halogen species – particularly Cl2 – from sea ice and snow surfaces is not well understood. In this study, we used a photochemical snow reactor coupled to a chemical ionization mass spectrometer to investigate the production of Br2, BrCl and Cl2 from NaCl/NaBr-doped artificial snow samples. At temperatures above the NaCl-water eutectic, illumination of samples (λ > 310 nm in the presence of gas phase O3 led to the accelerated release of Br2, BrCl and the release of Cl2 in a process that was significantly enhanced by acidity, high surface area and additional gas phase Br2. Cl2 production was only observed when both light and ozone were present. The total halogen release depended on [O3] and pre-freezing [NaCl]. Our observations support a "halogen explosion" mechanism occurring within the snowpack which is initiated by heterogeneous oxidation, and propagated by Br2 or BrCl photolysis and by recycling of HOBr and HOCl into the snowpack. Our study implicates an important role for active chemistry occurring within the interstitial air of aged (i.e., acidic snow for halogen activation at polar sunrise.

  9. Photochemical chlorine and bromine activation from artificial saline snow

    Directory of Open Access Journals (Sweden)

    S. N. Wren

    2013-10-01

    Full Text Available The activation of reactive halogen species – particularly Cl2 – from sea ice and snow surfaces is not well understood. In this study, we used a photochemical snow reactor coupled to a chemical ionization mass spectrometer to investigate the production of Br2, BrCl and Cl2 from NaCl/NaBr-doped artificial snow samples. At temperatures above the NaCl-water eutectic, illumination of samples (λ > 310 nm in the presence of gas phase O3 led to the accelerated release of Br2, BrCl and the release of Cl2 in a process that was significantly enhanced by acidity, high surface area and additional gas phase Br2. Cl2 production was only observed when both light and ozone were present. The total halogen release depended on [ozone] and pre-freezing [NaCl]. Our observations support a "halogen explosion" mechanism occurring within the snowpack, which is initiated by heterogeneous oxidation and propagated by Br2 or BrCl photolysis and by recycling of HOBr and HOCl into the snowpack. Our study implicates this important role of active chemistry occurring within the interstitial air of aged (i.e. acidic snow for halogen activation at polar sunrise.

  10. Photochemical chlorine and bromine activation from artificial saline snow

    Science.gov (United States)

    Wren, S. N.; Donaldson, D. J.; Abbatt, J. P. D.

    2013-10-01

    The activation of reactive halogen species - particularly Cl2 - from sea ice and snow surfaces is not well understood. In this study, we used a photochemical snow reactor coupled to a chemical ionization mass spectrometer to investigate the production of Br2, BrCl and Cl2 from NaCl/NaBr-doped artificial snow samples. At temperatures above the NaCl-water eutectic, illumination of samples (λ > 310 nm) in the presence of gas phase O3 led to the accelerated release of Br2, BrCl and the release of Cl2 in a process that was significantly enhanced by acidity, high surface area and additional gas phase Br2. Cl2 production was only observed when both light and ozone were present. The total halogen release depended on [ozone] and pre-freezing [NaCl]. Our observations support a "halogen explosion" mechanism occurring within the snowpack, which is initiated by heterogeneous oxidation and propagated by Br2 or BrCl photolysis and by recycling of HOBr and HOCl into the snowpack. Our study implicates this important role of active chemistry occurring within the interstitial air of aged (i.e. acidic) snow for halogen activation at polar sunrise.

  11. The gas metallicity gradient and the star formation activity of disc galaxies

    CERN Document Server

    Tissera, Patricia B; Sillero, Emanuel; Vilchez, Jose M

    2015-01-01

    We study oxygen abundance profiles of the gaseous disc components in simulated galaxies in a hierarchical universe. We analyse the disc metallicity gradients in relation to the stellar masses and star formation rates of the simulated galaxies. We find a trend for galaxies with low stellar masses to have steeper metallicity gradients than galaxies with high stellar masses at z ~0. We also detect that the gas-phase metallicity slopes and the specific star formation rate (sSFR) of our simulated disc galaxies are consistent with recently reported observations at z ~0. Simulated galaxies with high stellar masses reproduce the observed relationship at all analysed redshifts and have an increasing contribution of discs with positive metallicity slopes with increasing redshift. Simulated galaxies with low stellar masses a have larger fraction of negative metallicity gradients with increasing redshift. Simulated galaxies with positive or very negative metallicity slopes exhibit disturbed morphologies and/or have a clo...

  12. Antiurolithiatic Activity of Extract and Oleanolic Acid Isolated from the Roots of Lantana camara on Zinc Disc Implantation Induced Urolithiasis.

    Science.gov (United States)

    Vyas, Narendra; Argal, Ameeta

    2013-01-01

    The present study was done to evaluate the antiurolithiatic activity of ethanolic extract of roots (ELC 200 mg/kg) and oleanolic acid (OA 60 mg/kg, O.A. 80 mg/kg, O.A. 100 mg/kg) isolated from roots of Lantana camara in albino wistar male rats using zinc disc implantation induced urolithiatic model. The group in which only zinc disc was implanted without any treatment showed increase in calcium output (23  ± 2.7 mg/dL). Cystone receiving animals showed significant protection from such change (P urolitiasis. Thus, OA and ELC showed promising antiurolithiatic activity in dose dependant manner.

  13. The determination of aldehyde oxidase activity patterns in the wing discs of Drosophila melanogaster : Absence of field size influence during the third larval instar.

    Science.gov (United States)

    McCrady, Edward; Sprey, Th E

    1986-07-01

    The pattern of aldehyde oxidase (AO) activity was determined in wing discs of Drosophila melanogaster larvae homozygous for the mutants apt (73n), Beaded, and vestigial (vg) in order to determine if reduction in field size in the pouch could be related to alterations of the wild-type AO pattern, as suggested by the Kauffman (1978) hypothesis. The pattern in wild-type discs was resolved into six areas for comparison with mutant discs. vg discs developed at 25° C showed restriction of the pattern into a small area on the anterior side of the disc, and comparison of vg and wild-type prepupal wings allowed positive identification of the AO pattern elements which remained. AO patterns in vg wing discs grown at 27°, 29°, and 31° C were progressively more complete and similar to wild-type, reflecting the reduction in cell death in discs grown at higher temperatures. These results show that cell loss during the third instar in vg development at 25° C is responsible for the alteration of the AO pattern, rather than field size reduction, and that determination of the pattern must take place much earlier than the time of its first appearance during the third larval instar, and before cell death in vg discs begins. Thus mutants acting at earlier stages will be necessary for further tests of the Kauffman hypothesis.

  14. 推拿配合人工单下肢牵引治疗腰椎间盘突出症%Manipulation Combined with Artificial Single Lower Limb Traction in the Treatment of Lumbar Disc Herniation

    Institute of Scientific and Technical Information of China (English)

    李宏龙; 平晓慧

    2013-01-01

    Objective:To observe the clinical effect of artificial single lower limb traction combined with manipulation in the treatment of lumbar disc herniation. Methods:96 patients were randomly divided into observation group and control group. Observation group was treated with artificial sin-gle lower limb traction combined with manipulation, while control group was treated with double lower limb hammer traction. The clinical efficacy was compared between the two groups. Results:The total effective rate was 95.83%in observation group and 85.42%in control group with signifi-cant difference (P<0.05). The clinical effect in the observation group was better than that of control group. Conclusion:Artificial single lower limb traction is superior to traditional double lower limb hammer traction in the treatment of lumbar disc herniation.%目的:观察人工单下肢牵引法配合推拿治疗腰椎间盘突出症的疗效。方法:将96例患者随机分为观察组和对照组,观察组采用人工单下肢牵引法配合推拿治疗;对照组采用双下肢重锤牵引法配合推拿治疗,比较两组临床疗效。结果:观察组总有效率为95.83%,高于对照组的85.42%(P<0.05)。结论:人工单下肢牵引法治疗腰椎间盘突出症疗效优于传统的双下肢重锤牵引法。

  15. A new code to study structures in collisionally active, perturbed debris discs. Application to binaries

    CERN Document Server

    Thebault, Philippe

    2011-01-01

    Debris discs are traditionally studied using two distinct types of numerical models: statistical particle-in-a-box codes to study their collisional and size distribution evolution, and dynamical N-body models to study their spatial structure. The absence of collisions from N-body codes is in particular a major shortcoming, as collisional processes are expected to significantly alter the results obtained from pure N-body runs. We present a new numerical model, to study the spatial structure of perturbed debris discs at dynamical and collisional steady-state. We focus on the competing effects between gravitational perturbations by a massive body (planet or star), collisional production of small grains, and radiation pressure placing these grains in possibly dynamically unstable regions. We consider a disc of parent bodies at dynamical steady-state, from which small radiation-pressure-affected grains are released in a series of runs, each corresponding to a different orbital position of the perturber, where part...

  16. Accretion disc dynamo activity in local simulations spanning weak-to-strong net vertical magnetic flux regimes

    CERN Document Server

    Salvesen, Greg; Armitage, Philip J; Begelman, Mitchell C

    2015-01-01

    Strongly magnetized accretion discs around black holes have attractive features that may explain enigmatic aspects of X-ray binary behaviour. The structure and evolution of these discs are governed by a dynamo-like mechanism, which channels part of the accretion power liberated by the magnetorotational instability (MRI) into an ordered toroidal magnetic field. To study dynamo activity, we performed three-dimensional, stratified, isothermal, ideal magnetohydrodynamic shearing box simulations. The strength of the self-sustained toroidal magnetic field depends on the net vertical magnetic flux, which we vary across almost the entire range over which the MRI is linearly unstable. We quantify disc structure and dynamo properties as a function of the initial ratio of mid-plane gas pressure to vertical magnetic field pressure, $\\beta_0^{\\rm mid} = p_{\\rm gas} / p_B$. For $10^5 \\geq \\beta_0^{\\rm mid} \\geq 10$ the effective $\\alpha$-viscosity parameter scales as a power-law. Dynamo activity persists up to and includin...

  17. Artificial Metalloenzymes for Asymmetric Catalysis by Creation of Novel Active Sites in Protein and DNA Scaffolds

    NARCIS (Netherlands)

    Drienovska, Ivana; Roelfes, Gerard

    2015-01-01

    Artificial metalloenzymes have emerged as a promising new approach to asymmetric catalysis. In our group, we are exploring novel artificial metalloenzyme designs involving creation of a new active site in a protein or DNA scaffold that does not have an existing binding pocket. In this review, we giv

  18. Visualizing the Hidden Activity of Artificial Neural Networks.

    Science.gov (United States)

    Rauber, Paulo E; Fadel, Samuel G; Falcao, Alexandre X; Telea, Alexandru C

    2017-01-01

    In machine learning, pattern classification assigns high-dimensional vectors (observations) to classes based on generalization from examples. Artificial neural networks currently achieve state-of-the-art results in this task. Although such networks are typically used as black-boxes, they are also widely believed to learn (high-dimensional) higher-level representations of the original observations. In this paper, we propose using dimensionality reduction for two tasks: visualizing the relationships between learned representations of observations, and visualizing the relationships between artificial neurons. Through experiments conducted in three traditional image classification benchmark datasets, we show how visualization can provide highly valuable feedback for network designers. For instance, our discoveries in one of these datasets (SVHN) include the presence of interpretable clusters of learned representations, and the partitioning of artificial neurons into groups with apparently related discriminative roles.

  19. Overlapping inflows as catalysts of AGN activity - II: Relative importance of turbulence and inflow-disc interaction

    CERN Document Server

    Carmona-Loaiza, Juan Manuel; Dotti, Massimo; Valdarnini, Riccardo

    2015-01-01

    The main challenge for understanding the fuelling of supermassive black holes in active galactic nuclei is not to account for the source of fuel, but rather to explain its delivery from the boundaries of the black hole sphere of influence (10-100 pc) down to sub-parsec scales. In this work, we report on a series of numerical experiments aimed at exploring in further depth our model of "overlapping inflow events" as catalysts for rapid accretion, seeding a turbulent field in the infalling gas. We initially set a gaseous shell in non-equilibrium rotation around a supermassive black hole. After infall, the shell stalls in a disc-like structure. A second shell is then set in either co-rotation or counter-rotation with respect to the first and is let to impinge on the previously-formed disc. We find that combined turbulence and overlap significantly enhance accretion in counter-rotating inflows, while turbulence dominates for co-rotating inflows. The leftovers of overlapping inflows are warped nuclear discs, whose...

  20. The short-term efficacy of Prestige LP artificial disc single-level replacement for cervical spondylosis%Prestige LP人工椎间盘置换治疗单节段颈椎病的近期疗效

    Institute of Scientific and Technical Information of China (English)

    黄波; 卢一生; 施建东; 徐静芳; 刘振刚

    2014-01-01

    Objective To evaluate the short-term radiological and functional outcome of artifi-cial disc single-level replacement for cervical disc degenerative diseases. Methods 15 patients with cervical disc degenerative diseases underwent Prestige LP artificial disc replacement were se-lected in this study. There were 8 cases of cervical spondylotic myelopathy and 7 cases of nerve root cervical syndrome. The range of motion(ROM) of the cervical spine,ROM of treated segment and lordosis of cervical spine were reviewed respectively at preoperation and 1 month,3 months and 12 months postoperation,and the NDI scores,VAS for neck and arm pain were also reviewed respectively preoperation and the last follow-up. Results At an average of 16.3 months(range 6-24 months) follow-up,the neurologic symptom and sign in all cases had significant improvement. The NDI was significantly improved from(47.80±11.52)% to(16.20±9.34)%(P<0.05),the VAS for neck and arm pain were all significantly improved from(5.13±1.44) and (6.30±1.51) to (1.46±0. 81) and (1.14 ±0.57) respectively (P<0.05). The lordosis of cervical spine was significantly in-creased at follow up (P<0.05). The ROM of the cervical spine and ROM of treated segment re-covered to the preoperative level. There was no neurological complication during operation,and no ossification in the replaced level and no prosthesis displacement and loosening . Conclusion Our findings suggest that the Prestige LP cervical disc replacement in the treatment of cervical disc degenerative diseases has good functional short-term results, further follow-up is necessary to e-valuate mid- and long-term outcome.%目的:探讨应用Prestige LP人工椎间盘置换治疗单节段颈椎病的近期临床疗效。方法治疗单节段颈椎病患者15例,统计并分析患者术前和术后1、3、12个月随访时JOA评分、NDI脊髓功能评分、颈部及上肢疼痛VAS评分、置换节段活动度、颈椎运动范围、颈椎生理曲度等指标

  1. Observation on early therapeutic effect of DISCOVER artificial cervical disc replacement for cervical spondylotic myelopathy%DISCOVER人工颈椎间盘置换术治疗脊髓型颈椎病的早期疗效观察

    Institute of Scientific and Technical Information of China (English)

    钱俊; 辛兵; 何玉泽; 郭开今

    2013-01-01

    目的 探讨应用DISCOVER人工颈椎间盘置换术治疗脊髓型颈椎病的早期临床疗效.方法 回顾性分析行DISCOVER人工颈椎间盘置换术的12例脊髓型颈椎病患者的临床资料,统计并分析患者术前和术后神经功能状态JOA评分和颈椎总活动度(ROM),进行早期疗效评估.结果 所有患者随访6个月,术后临床症状和体征明显改善或消失,JOA评分由术前的(6.79±3.62)分提高到末次随访的(15.84 ±0.89)分(P<0.05);ROM术前为(51.3 ±14.2)°,术后末次随访为(49.9±13.8)°,差异无统计学意义(P>0.05).按照Odom评定标准,末次随访时,优9例,良2例,可1例,优良率91.7%.结论 应用DISCOVER人工颈椎间盘置换术治疗脊髓型颈椎病早期疗效良好,远期效果有待进一步观察.%Objective To evaluate the early clinical efficacy of DISCOVER artificial cervical disc replacement sur gery for cervical spondylotic myelopathy. Methods The clinical data of 12 patients with cervical spondylotic myelopathy undergoing DISCOVER artificial cervical disc replacement was analyzed retrospectively. Preoperative and postoperative neurological status JOA scores and cervical range of motion (ROM) were compared and early therapeutic efficacy was e-valuated. Results All patients were followed - up for 6 months. The neurological symptoms and signs were alleviated or disappeared in all cases. The JOA score was significantly improved from 6. 79 ±3. 62 preoperatively to 15. 84 ±0. 89 at the last postoperative follow - up (P 0. 05 ). According to Odom criteria, 9 cases got excellent results, 3 cases got good results, 1 case got fair results. The rate of excellent and good results was 91.7%. Conclusion Our findings suggest that the DISCOVER cervical disc replacement for cervical spondylotic myelopathy may yield good short - term functional results. Further follow - up is necessary to evaluate mid and long - term outcome.

  2. Dynamics of warped accretion discs

    OpenAIRE

    Tremaine, Scott; Davis, Shane W.

    2013-01-01

    Accretion discs are present around both stellar-mass black holes in X-ray binaries and supermassive black holes in active galactic nuclei. A wide variety of circumstantial evidence implies that many of these discs are warped. The standard Bardeen--Petterson model attributes the shape of the warp to the competition between Lense--Thirring torque from the central black hole and viscous angular-momentum transport within the disc. We show that this description is incomplete, and that torques from...

  3. Effects of osmotic stress on antioxidant enzymes activities in leaf discs of PSAG12-IPT modified gerbera

    Institute of Scientific and Technical Information of China (English)

    LAI Qi-xian; BAO Zhi-yi; ZHU Zhu-jun; QIAN Qiong-qiu; MAO Bi-zeng

    2007-01-01

    Leaf senescence is often caused by water deficit and the chimeric gene PSAG12-IPT is an auto-regulated gene delaying leaf senescence. Using in vitro leaf discs culture system, the changes of contents of chlorophylls, carotenoids, soluble protein and thiobarbituric acid reactive substance (TBARS) and antioxidant enzymes activities were investigated during leaf senescence of PSAG12-IPT modified gerbera induced by osmotic stress compared with the control plant (wild type). Leaf discs were incubated in 20%, 40% (w/v) polyethylene glycol (PEG) 6 000 nutrient solution for 20 h under continuous light [130 μmol/(m2·s)]. The results showed that the contents of chlorophylls, carotenoids and soluble protein were decreased by osmotic stress with the decrease being more pronounced at 40% PEG, but that, at the same PEG concentration the decrease in the transgenic plants was significantly lower than that in the control plant. The activities of superoxide dismutase (SOD), catalases (CAT), ascorbate peroxidase (APX),guaiacol peroxidase (GPX) and dehydroascorbate reductase (DHAR) were stimulated by PEG treatment. However, the increases were higher in PSAG12-IPT transgenic plants than in the control plants, particularly at 40% PEG treatment. Lipid peroxidation (TBARS content) was increased by PEG treatment with the increase being much lower in transgenic plant than in the control plant.It could be concluded that the increases in the activities of antioxidant enzymes including SOD, CAT, APX, GPX and DHAR were responsible for the delay of leaf senescence induced by osmotic stress.

  4. Galaxy Zoo: the effect of bar-driven fueling on the presence of an active galactic nucleus in disc galaxies

    CERN Document Server

    Galloway, Melanie A; Fortson, Lucy F; Cardamone, Carolin N; Schawinski, Kevin; Cheung, Edmond; Lintott, Chris J; Masters, Karen L; Melvin, Thomas; Simmons, Brooke D

    2015-01-01

    We study the influence of the presence of a strong bar in disc galaxies which host an active galactic nucleus (AGN). Using data from the Sloan Digital Sky Survey and morphological classifications from the Galaxy Zoo 2 project, we create a volume-limited sample of 19,756 disc galaxies at $0.01

  5. X-ray observational signature of a black hole accretion disc in an active galactic nucleus RXJ1633+4718

    CERN Document Server

    Yuan, Weimin; Zhou, Hongyan; Wang, Tinggui

    2010-01-01

    We report the discovery of a luminous ultra-soft X-ray excess in a radio-loud narrow-line Seyfert1 galaxy, RXJ1633+4718, from archival ROSAT observations. The thermal temperature of this emission, when fitted with a blackbody, is as low as 32.5(+8.0,-6.0)eV. This is in remarkable contrast to the canonical temperatures of ~0.1-0.2keV found hitherto for the soft X-ray excess in active galactic nuclei (AGN), and is interestingly close to the maximum temperature predicted for a postulated accretion disc in this object. If this emission is indeed blackbody in nature, the derived luminosity [3.5(+3.3,-1.5)x10^(44)ergs/s] infers a compact emitting area with a size [~5x10^(12)cm or 0.33AU in radius] that is comparable to several times the Schwarzschild radius of a black hole at the mass estimated for this AGN (3x10^6Msun). In fact, this ultra-steep X-ray emission can be well fitted as the (Compton scattered) Wien tail of the multi-temperature blackbody emission from an optically thick accretion disc, whose parameters...

  6. 颈椎间盘置换治疗颈椎病的疗效观察%Efficacy evaluation of treating cervical spondylopathy with the Discover artificial cervical disc prosthesis

    Institute of Scientific and Technical Information of China (English)

    方礼明; 张亚军; 张军; 李勤

    2013-01-01

    Objective To explore the clinical and radiological outcomes of Discover artificial cervical disc arthroplasty and the range of motion status on adjacent segments for cervical spondylosis causing radiculopathy or myelopathy.Methods A total of 18 consecutive patients underwent cervical arthroplasty with the Discover artificial cervical disc at our hospital.Clinical and radiological follow-ups were conducted.Their radiographic parameters of treatment and adjacent segments were evaluated at Month 1,3,6,12,18 post-operation.And the Japanese Orthopedic Association (JOA) score,visual analog scale (VAS) pain score and Odom's scale were recorded and analyzed.Results During follow-ups over an average of 15 months,there was no occurrence of vascular injury,severe complications or prosthesis displacement and loosening.The score of JOA was 7.2 ± 1.8 at preoperation and 16.7 ± 4.5 at postoperation.And the score of VAS was 8.15 ± 1.65 at preoperation and 2.03 ± 1.12 at postoperation.Conclusion Discover artificial cervical disc arthroplasty is efficacious and the patients recover quickly.Targeted cervical segments may be stabilized and their physiological ranges of motion preserved.%目的 探讨颈椎人工间盘治疗脊髓型和神经根型颈椎病术后的临床效果.方法 2008年6月至2010年6月,武警北京市总队第二医院骨科18例保守治疗无效的颈椎病患者行DiscoverTM人工颈椎间盘置换术,术后按计划随访术后1、3、6、12、18个月,记录术前和术后每个时间点JOA评分,Odom分级及VAS评分.术前、术后3、6、12、18个月登记颈椎正侧及动力位X线片,分析评价椎间盘的位置.结果 18例患者均获得随访,平均随访15个月,术后未出现血管神经损伤,无严重并发症发生.术后患者未发现假体松动和移位.JOA评分从术前(7.2±1.8)分到术后(16.7±4.5)分,VAS评分从术前(8.4±1.4)分到术后(2.0±1.1)分,术后手术效果按照Odom分级都是优良结果,优16例,良2

  7. A Novel Wearable Sensor-Based Human Activity Recognition Approach Using Artificial Hydrocarbon Networks.

    Science.gov (United States)

    Ponce, Hiram; Martínez-Villaseñor, María de Lourdes; Miralles-Pechuán, Luis

    2016-07-05

    Human activity recognition has gained more interest in several research communities given that understanding user activities and behavior helps to deliver proactive and personalized services. There are many examples of health systems improved by human activity recognition. Nevertheless, the human activity recognition classification process is not an easy task. Different types of noise in wearable sensors data frequently hamper the human activity recognition classification process. In order to develop a successful activity recognition system, it is necessary to use stable and robust machine learning techniques capable of dealing with noisy data. In this paper, we presented the artificial hydrocarbon networks (AHN) technique to the human activity recognition community. Our artificial hydrocarbon networks novel approach is suitable for physical activity recognition, noise tolerance of corrupted data sensors and robust in terms of different issues on data sensors. We proved that the AHN classifier is very competitive for physical activity recognition and is very robust in comparison with other well-known machine learning methods.

  8. Trans-activation of an artificial dTam3 transposable element in transgenic tobacco plants

    NARCIS (Netherlands)

    Haring, Michel A.; Teeuwen-de Vroomen, Marianne J.; Nijkamp, H. John J.; Hille, Jacques

    1991-01-01

    In Antirrhinum majus only autonomous Tam3 transposons have been characterized. We investigated whether an artificial dTam3 element, with a deletion in the presumptive transposase coding region, can be trans-activated in tobacco by an activator Tam3 element, which was immobilized by the deletion of o

  9. ADJACENT SEGMENT DEGENERATION AFTER CERVICAL ARTIFICIAL DISC REPLACEMENT AT EARLY MID-TERM FOLLOW-UP%人工颈椎间盘置换术后邻近节段退变情况的早中期随访

    Institute of Scientific and Technical Information of China (English)

    刘雅普; 夏虹; 艾福志; 石林; 隋文渊

    2012-01-01

    Objective To study the effectiveness of artificial disc replacement for cervical diseases and the adjacent segment degeneration. Methods Between January 2008 and October 2010, 39 cases of cervical spondylosis underwent cervical disc replacement. Of them, there were 20 males and 19 females with an average age of 45.7 years (range, 32-60 years) and an average disease duration of 30 months (range, 1 month to 10 years), including 26 cases of cervical myelopathy, 11 cases of nerve root cervical spondylosis, and 2 cases of mixed cervical spondylosis. Single level disc lesion was observed in 27 cases while bi-level lesion in 12 cases. Prestige disc prosthesis was used in 9 patients, Prodisc-C prosthesis in 4 patients, and Discover disc prosthesis in 26 patients. The neurological functional recovery was assessed after operation by Japanese Orthopaedic Association (JOA) score. The range of motion of replaced segment and adjacent segments was measured (Cobb angle), and Kellgren's X-ray assessment was used to evaluate the degree of adjacent segment degeneration. Results The operation was successfully performed in all cases, with primary healing of all the incisions. All patients were followed up from 12 to 36 months with an average of 23.1 months. JOA score was significantly improved at last follow-up when compared with preoperative score (P 0.05). According to the Kellgren's X-ray assessment, degeneration of the adjacent segments occurred in 5 cases at last follow-up, including 3 cases of degeneration from grade 0 to grade 1 or 2, 1 from grade 1 to grade 2, and 1 from grade 2 to grade 3, with a degeneration rate of 12.8%, but no significant difference was found in degeneration degree when compared with preoperative value (X2=1.793, P=0.406). No degeneration of adjacent segments occurred in 32 patients at 15 months after operation. Conclusion Artificial disc replacement has a good effectiveness in treating cervical spondylosis, which can maintain the range of motion of the

  10. Artificial Total Disc Replacement for Lumbar Degenerative Disc Disease: A Systematic Review%人工全椎间盘置换治疗退行性腰椎间盘疾病的系统评价

    Institute of Scientific and Technical Information of China (English)

    何祖胜; 白靖平; 锡林宝勒日; 金格勒; 吴泰相; 李静

    2005-01-01

    目的分析人工全椎间盘置换治疗退行性腰椎间盘疾病的疗效.方法计算机检索Cochrane图书馆(2004年第2期)中的临床对照试验资料库和Cochrane协作网背痛专业试验数据库、MEDLINE(1966~2004)、EMBASE(1980~2004)、中国生物医学文献光盘数据库(CBMdisk,2003),手工检索中文文献(截自2004年6月),并询问相关厂家以及研究者.由两名评价员独立提取资料,并按Cochrane协作网提供的方法对纳入文献进行质量评价和结果分析.结果共纳入3个RCT,包括152例患者.文献质量评价结果显示,3个RCT均可能存在选择性偏倚、实施偏倚和测量偏倚的高度可能性.其中两篇使用ProDisc-Ⅱ人工全椎间盘置换,1篇使用SB-Ⅲ人工全椎间盘置换.3个RCT均未提供详细的原始数据,因此不能进行Meta分析.人工全椎间盘置换组病人术后早期VAS疼痛评分(visual analog scale)和ODI功能评分(oswestry disability index)有改善,但术后6个月与融合组无差异.病人满意率,术后6个月人工全椎间盘置换组有优于融合组的趋势.短期随访显示,人工椎间盘能够保存受累节段的运动功能.两篇RCT报告了相关并发症.结论人工全椎间盘置换短期内能够重建退变节段的高度及生理运动功能,但缺乏长期的随访,尤其对于能否防止毗邻节段的退变缺乏证据.尚需更多设计严格的研究以增加证据的强度.

  11. Sorption and biodegradation of artificial sweeteners in activated sludge processes.

    Science.gov (United States)

    Tran, Ngoc Han; Gan, Jie; Nguyen, Viet Tung; Chen, Huiting; You, Luhua; Duarah, Ankur; Zhang, Lifeng; Gin, Karina Yew-Hoong

    2015-12-01

    There is limited information on the occurrence and removal of artificial sweeteners (ASs) in biological wastewater treatment plants, and in particular, the contribution of sorption and biodegradation to their removal. This study investigated the fate of ASs in both the aqueous and solid phases in a water reclamation plant (WRP). All the four targeted ASs, i.e. acesulfame (ACE), sucralose (SUC), cyclamate (CYC) and saccharine (SAC), were detected in both the aqueous and solid phases of raw influent and primary effluent samples. The concentrations of CYC and SAC in secondary effluent or MBR permeate were below their method detection limits. ACE and SUC were persistent throughout the WRP, whereas CYC and SAC were completely removed in biological treatment (>99%). Experimental results showed that sorption played a minor role in the elimination of the ASs due to the relatively low sorption coefficients (Kd), where Kd<500L/kg. In particular, the poor removal of ACE and SUC in the WRP may be attributed to their physiochemical properties (i.e. logKow<0 or logD<3.2) and chemical structures containing strong withdrawing electron functional groups in heterocyclic rings (i.e. chloride and sulfonate).

  12. Prosthetic Lumbar disc replacement for degenerative disc disease

    Directory of Open Access Journals (Sweden)

    Kulkarni Arvind

    2005-01-01

    Full Text Available Mechanical articulated device to replace intervertebral disc as a treatment for low back pain secondary to disc degeneration has emerged as a promising tool for selected patients. The potential advantages are prevention of adjacent segment degeneration, maintenance of mobility as well as avoidance of all the complications associated with fusion. The short-term results have been comparable to that of fusion, a few mid-term results have shown mixed outcome, but information on long-term results and performance are not available at present. The rationale for lumbar disc arthroplasty, indications, contraindications, the various artificial devices in the market and the concepts intrinsic to each of them, basic technique of insertion, complications are discussed and a brief summary of our experience with one of the devices is presented.

  13. 与人工髓核置换相关的国人腰椎间盘结构测量%Measurement of lumbar disc related to artificial nucleus pulposus replacement in Chinese

    Institute of Scientific and Technical Information of China (English)

    王子轩; 单涛

    2012-01-01

    BACKGROUND: Surgeons usually predict the size and number of nucleus pulposus (NP) prosthesis before operation according to the diameters of lumbar intervertebral disc measured on medical images.OBJECTIVE: To measure and analyze height of lumbar intervertebral space, lumbar disc and NP diameters in normal for obtaining basic data of intervertebral disc related to artificial prosthetic nucleus.METHODS: Totally 157 lumbar spine X-ray films (Lateral views) of normal adult were randomly selected. Anterior, middle and posterior heights of lumbar intervertebral space were measured on X-ray films. A total of 106 lumbar Magnatic Resonance Imaging (MRI) images of normal adult were randomly selected for measuring transverse diameter and antero-posterior diameter (A-P diameter) of NP and lumbar disc.RESULTS AND CONCLUSION: ? X-ray film: from upper to lower, the height of intervertebral space increased gradually. Posterior height of lumbar intervertebral space was low. It ranged between 7 mm and 9 mm, approximately 50% at L2/3, L3/4, and L4/5, about 39.5% at L5/S1. ? MRI images: from L2/3 to L5/S1, the transverse diameter and A-P diameter of lumbar disc enlarged in turn. About 46.7% A-P diameter of lumbar discs were more than 37 mm. However, only 49.0% were proved that the A-P diameters of NP were more than 24 mm. In this study, the average transverse diameter of NP was 33.5 mm, the average A-P diameter was 23.4 mm. The A-P diameters of NP were all more than 12 mm. Among these, about 22.9% were more than 24 mm. The results indicated that single prosthetic disc nucleus (PDN) is suitable for most Chinese patients, and the height of 7 mm of PDN is commonly chosen. The A-P diameter of lumbar disc ranging from 37 mm is demonstrated unreliable to predict double PDN replacement before operation in Chinese.%背景:临床多根据影像资料中腰椎间盘径线尺寸来选择假体型号和预计置入数量.目的:以X射线片和MRI测量分析正常人腰椎间隙高度、腰椎

  14. Galaxy Zoo: the effect of bar-driven fuelling on the presence of an active galactic nucleus in disc galaxies

    Science.gov (United States)

    Galloway, Melanie A.; Willett, Kyle W.; Fortson, Lucy F.; Cardamone, Carolin N.; Schawinski, Kevin; Cheung, Edmond; Lintott, Chris J.; Masters, Karen L.; Melvin, Thomas; Simmons, Brooke D.

    2015-04-01

    We study the influence of the presence of a strong bar in disc galaxies which host an active galactic nucleus (AGN). Using data from the Sloan Digital Sky Survey and morphological classifications from the Galaxy Zoo 2 project, we create a volume-limited sample of 19 756 disc galaxies at 0.01 < z < 0.05 which have been visually examined for the presence of a bar. Within this sample, AGN host galaxies have a higher overall percentage of bars (51.8 per cent) than inactive galaxies exhibiting central star formation (37.1 per cent). This difference is primarily due to known effects: that the presence of both AGN and galactic bars is strongly correlated with both the stellar mass and integrated colour of the host galaxy. We control for this effect by examining the difference in AGN fraction between barred and unbarred galaxies in fixed bins of mass and colour. Once this effect is accounted for, there remains a small but statistically significant increase that represents 16 per cent of the average barred AGN fraction. Using the L_{[O III]}/MBH ratio as a measure of AGN strength, we show that barred AGNs do not exhibit stronger accretion than unbarred AGNs at a fixed mass and colour. The data are consistent with a model in which bar-driven fuelling does contribute to the probability of an actively growing black hole, but in which other dynamical mechanisms must contribute to the direct AGN fuelling via smaller, non-axisymmetric perturbations.

  15. Medium term efficacy analysis of bi-level BRYAN artificial cervical disc replacement for the treatment of cervical spondylosis%双节段BRYAN人工颈间盘置换的中期疗效分析

    Institute of Scientific and Technical Information of China (English)

    种涛; 俞兴; 贾育松; 李春根; 柳根哲; 毕连涌; 徐林

    2013-01-01

    [ Objective]To observe the clinical effect and imaging results of the treatment of adjacent segment cervical spon-dylosis in the adjacent bi - level BRYAN cervical disc replacement. [ Method] A retrospective studying was performed on 19 cases of cervical spondylosis receiving adjacent bi - level BRYAN artificial cervical disc replacement and were followed up from January 2006 to February 2009 in our hospital. Clinical outcome of surgery was evaluated by Japanese Orthopaedic Association score (JOA) , neck disability index(NDI) and visual analogue pain scale (VAS)for neck pain before surgery and at 1 week,3, 6,12,24,36 months after surgery respectively. The range of motion (ROM) of the surgical segments, the upper and lower adjacent segments, and C2-7 was assessed by cervical dynamic X - ray film before operation and 3 ,6,12,24,36 months after sugery. Operative adjacent segment degeneration was assessed by X - ray disc degeneration scoring system 12,24 and 36 months after surgery. [Result]The neurological symptoms of each patients were significantly improved. The postoperative JOA score , NDI scores, neck pain VAS scores were improved significantly at each follow - up time point compared with those of preoperation, difference was statistically significant (P 0. 05). ROM of the two operative segment increased significantly compared with the preoperative each time point after 3 - month follow - up (P 0. 05). To the last follow - up, the surgery had not led to adjacent segment disc degeneration exacerbated and no serious complications occurred. [ Conclusion ] The clinical result of BRYAN artificial cervical disc replacement in the treatment of adjacent bi - level cervical degenerative disc disease is good, not only reserving the kinematic characteristics of operative segment, adjacent segments , C2-7 segment but preventing of adjacent segment degeneration. No serious complication occurs during mediterm follow - up.%[目的]观察相邻双节段BRYAN人工颈椎间盘

  16. Active galactic nuclei at z ~ 1.5: III. Accretion discs and black hole spin

    CERN Document Server

    Capellupo, Daniel M; Lira, Paulina; Trakhtenbrot, Benny; Mejía-Restrepo, Julián

    2016-01-01

    This is the third paper in a series describing the spectroscopic properties of a sample of 39 AGN at $z \\sim 1.5$, selected to cover a large range in black hole mass ($M_{BH}$) and Eddington ratio ($L/L_{Edd}$). In this paper, we continue the analysis of the VLT/X-shooter observations of our sample with the addition of 9 new sources. We use an improved Bayesian procedure, which takes into account intrinsic reddening, and improved $M_{BH}$ estimates, to fit thin accretion disc (AD) models to the observed spectra and constrain the spin parameter ($a_*$) of the central black holes. We can fit 37 out of 39 AGN with the thin AD model, and for those with satisfactory fits, we obtain constraints on the spin parameter of the BHs, with the constraints becoming generally less well defined with decreasing BH mass. Our spin parameter estimates range from $\\sim$$-$0.6 to maximum spin for our sample, and our results are consistent with the "spin-up" scenario of BH spin evolution. We also discuss how the results of our anal...

  17. Active galactic nuclei at z ˜ 1.5 - III. Accretion discs and black hole spin

    Science.gov (United States)

    Capellupo, D. M.; Netzer, H.; Lira, P.; Trakhtenbrot, B.; Mejía-Restrepo, J.

    2016-07-01

    This is the third paper in a series describing the spectroscopic properties of a sample of 39 AGN at z ˜ 1.5, selected to cover a large range in black hole mass (MBH) and Eddington ratio (L/LEdd). In this paper, we continue the analysis of the VLT/X-shooter observations of our sample with the addition of nine new sources. We use an improved Bayesian procedure, which takes into account intrinsic reddening, and improved MBH estimates, to fit thin accretion disc (AD) models to the observed spectra and constrain the spin parameter (a*) of the central black holes. We can fit 37 out of 39 AGN with the thin AD model, and for those with satisfactory fits, we obtain constraints on the spin parameter of the BHs, with the constraints becoming generally less well defined with decreasing BH mass. Our spin parameter estimates range from ˜-0.6 to maximum spin for our sample, and our results are consistent with the `spin-up' scenario of BH spin evolution. We also discuss how the results of our analysis vary with the inclusion of non-simultaneous GALEX photometry in our thin AD fitting. Simultaneous spectra covering the rest-frame optical through far-UV are necessary to definitively test the thin AD theory and obtain the best constraints on the spin parameter.

  18. Artificial cervical disc replacement: range of motion of replacement segment and degeneration of adjacent segments%人工颈椎间盘置换:置换节段活动度及相邻节段退变分析

    Institute of Scientific and Technical Information of China (English)

    陈渲宇; 初冬; 伍骥; 郑超; 黄蓉蓉; 崔玉明; 尚咏; 范恒华; 虞攀峰; 赵旭红

    2015-01-01

    BACKGROUND:In recent years,artificial cervical disc replacement surgery as a new method for the treatment of cervical disease has gradualy been accepted and understood,but relevant complications have gradualy attracted attention.OBJECTIVE:To investigate the clinical outcomes of artificial cervical disc replacement in the treatment of cervical disease and the range of motion of the replacement segment.METHODS: A total of 25 patients with artificial cervical disc replacement in the treatment of cervical spondylosis,who were treated in the Department of Orthopedics,Air Force General Hospital of Chinese PLA from August 2006 to April 2012,were enroled in this study,including 15 males and 10 females,aged 31-76 years,averagely 51.04 years.There were 6 cases of double segments and 19 cases of single segment.They were folowed up for 24 to 93 months.Clinical results were assessed using the Japanese Orthopaedic Association score,cervical dysfunction index and pain visual analog scale scores.Imaging was used to observe range of motion,cervical curvature,heterotopic ossification,and degeneration of adjacent segments.RESULTS AND CONCLUSION:Neurological function in al patients was improved to different degrees.One case suffered from mild heterotopic ossification,but no clinical symptoms were found.No significant difference in range of motion of surgical segment,and range of motion of upper and lower adjacent segments was detected between pre-replacement and final folow-up results (P>0.05).No significant difference in range of motion of C2-C7 was found between pre-replacement and final folow-up results (P>0.05).Japanese Orthopaedic Association score,cervical dysfunction index and pain visual analog scale scores were significantly improved during final folow-up compared with pre-replacement (P<0.05).These results indicated that artificial cervical disc replacement in the treatment of cervical disease can achieve better clinical efficacy,can keep the range of motion of

  19. Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

    Directory of Open Access Journals (Sweden)

    Anton V. Gulevich

    2011-08-01

    Full Text Available The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.

  20. Application of Artificial Neural Network in Active Vibration Control of Diesel Engine

    Institute of Scientific and Technical Information of China (English)

    SUN Cheng-shun; ZHANG Jian-wu

    2005-01-01

    Artificial Neural Network (ANN) is applied to diesel twostage vibration isolating system and an AVC (Active Vibration Control) system is developed. Both identifier and controller are constructed by three-layer BP neural network. Besides computer simulation, experiment research is carried out on both analog bench and diesel bench. The results of simulation and experiment show a diminished response of vibration.

  1. Paraquat Resistance in Leaf Discs of PSAG12-IPT Modified Gerbera Is Related to the Activities of Superoxide Dismutase, Catalase, and Dehydroascorbate Reductase

    Institute of Scientific and Technical Information of China (English)

    LAI Qi-xian; BAO Zhi-yi; ZHU Zhu-jun; MAO Bi-zeng; QIAN Qiong-qiu

    2007-01-01

    In this paper, using in vitro leaf disc culture system, the changes of contents of chlorophylls, carotenoids, soluble protein, thiobarbituric acid reactive substance (TBARS), and activities of antioxidant enzymes were investigated during the incubation of leaf discs of PSAG12-IPT modified gerbera in 0, 25, 50 μmol L-1 paraquat (PQ) under continuous light intensity of 130 μmol m-2 s-1, compared with the control plant (wild type). The results showed that PQ treatment significantly decreased the contents of chlorophylls, carotenoids, and soluble protein, therefore, promoted leaf senescence. However, the decreases in the leaf discs of modified gerbera were considerably smaller. The activities of superoxide dismutase (SOD), catalase (CAT), and dehydroascorbate reductase (DHAR) were significantly increased by PQ treatment and with the increasing of PQ concentration, particularly in the modified plants. The activities of ascorbate peroxidase (APX) and guaiacol peroxidase (GPX) could not be detected in the leaf discs of PQ treatments, which suggested that they were labile to the oxidative stress induced by PQ. As a product of lipid peroxidation, TBARS significantly increased in content with the increase of PQ concentration, while its concentration in the modified plants was significantly lower than that of control plants. Therefore, it could be concluded that the chimeric gene PSAG12-IPT transformed gerbera leaves had higher antioxidative potential, thus causing the delay of senescence under oxidative stress induced by PQ.

  2. 人工颈椎间盘置换与前路颈椎间盘切除融合后邻近节段椎间盘应力分布的有限元对比%Comparison of stress distribution of adjacent segments after artificial cervical disc replacement versus anterior cervical discectomy and fusion:a finite element analysis

    Institute of Scientific and Technical Information of China (English)

    刘雅普; 侯秀伟; 吴广良; 夏虹

    2016-01-01

    背景:通过前期的临床随访研究发现,前路颈椎融合后邻近节段椎间盘退变速度要快于人工颈椎间盘置换,人工颈椎间盘置换相较于前路颈椎融合可以保持良好的置换节段活动度,是否置换后邻近椎间盘的应力情况与融合之间存在着差异需要进一步研究。目的:对比人工颈椎间盘置换与前路颈椎间盘切除融合后邻近节段椎间盘的应力分布情况。方法:选择1名30岁健康男性志愿者,人工颈椎间盘和颈椎前路钢板实物进行薄层CT扫描,通过Mimics 10.01及Geomagic Studio.v11软件重建出三维图像,将以上三维数据导入Abaqus 6.9有限元分析软件中进行网格划分、赋值、应力分析。利用有限元方法分析模拟人工颈椎间盘置换及前路颈椎间盘切除融合后邻近节段椎间盘的应力变化。结果与结论:①在相同的预载荷条件下,前屈、后伸、侧屈等运动状态时前路颈椎间盘切除融合后邻近节段椎间盘的应力明显大于正常人相应节段椎间盘应力;而人工椎间盘植入后与正常人相比,在前屈、后伸、侧屈等运动状态时邻近节段椎间盘的应力差异无显著性意义;②前路颈椎间盘切除融合组与人工颈椎间盘置换组相比较,融合组术后邻近节段椎间盘的应力较置换组增大10.3%-51.6%;③有限元分析方法发现,前路颈椎间盘切除融合后邻近节段椎间盘应力大于人工颈椎间盘置换组,随着随访时间的延长,相较于传统前路减压融合,人工颈椎间盘置换可能将更好地发挥其对邻近节段椎间盘的保护作用。%BACKGROUND:Previous clinical fol ow-up study showed that disc degeneration of adjacent segment after anterior cervical discectomy and fusion was faster than that of artificial cervical disc replacement. Compared with the anterior cervical discectomy and fusion, artificial cervical disc replacement can maintain a

  3. Optimal Recognition Method of Human Activities Using Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Oniga Stefan

    2015-12-01

    Full Text Available The aim of this research is an exhaustive analysis of the various factors that may influence the recognition rate of the human activity using wearable sensors data. We made a total of 1674 simulations on a publically released human activity database by a group of researcher from the University of California at Berkeley. In a previous research, we analyzed the influence of the number of sensors and their placement. In the present research we have examined the influence of the number of sensor nodes, the type of sensor node, preprocessing algorithms, type of classifier and its parameters. The final purpose is to find the optimal setup for best recognition rates with lowest hardware and software costs.

  4. Bryan人工椎间盘单节段置换治疗颈椎间盘退变性疾病的临床疗效%Clinic Therapeutic Effect of Bryan Artificial Disc Single Level Replacement on Cervical Disc Degenerative Diseases

    Institute of Scientific and Technical Information of China (English)

    石锐; 刘浩; 丁琛; 胡韬; 李涛; 龚全; 宋跃明; 洪瑛

    2011-01-01

    -up visiting at the expected time in the next two years after the operation. Patients' symptom scale, VAS for neck pain, VAS for arm pain, NDI were 2. 80 ±0. 42, 4. 62 ± 1. 84, 5. 01 ±1. 79, and 22. 60±4. 88, respectively before the operation and significantly decreased to 0. 20±0. 42, 1. 01±0. 56, 0. 82±0. 24, and 4. 30+1. 25, respectively at the end of the follow-up. All patients had good or higher score of the Odom score. The ymptoms were completely relieved in eight patients (38. 1%). The mean operation time was (110. 5±42. 6) minutes, the average blood loss was (166. 0±108. 8) mL. The normal motion of the artificial disc was observed. No cervical instability was observed. Two prosthesis migrated slightly. Conclusion Single segmental Bryan disc replacement is safe and effective on the cervical disc degeneration. The two-year follow-up reveales a satisfied clinical outcome.

  5. 颈椎前路减压人工颈椎间盘置换术与融合术治疗单节段颈椎间盘突出症的短期疗效比较%Clinical outcome of Discover artificial cervical disc replacement versus anterior cervical decompression and fusion for single segment cervical disc herniation

    Institute of Scientific and Technical Information of China (English)

    卡哈尔·艾肯木; 楚戈; 王振斌; 陈继征; 顾文飞; 胡雅斌; 涂来勇; 赵疆; 项泽文

    2014-01-01

    Background: The curative effect of anterior cervical discectomy and fusion (ACDF) is satisfactory for the patients with symptomatic cervical disc herniation. However, it can result in stress increase in adjacent segments and speed up the degen-eration of adjacent segments. Artificial cervical disc replacement (ACDR), a typical non-fusion surgical treatment, may be an alternative to ACDF for cervical disc herniation. Objective:To compare the clinical outcomes between ACDR and ACDF for single segmental cervical disc herniation. Methods:From January 2009 to February 2012, 61 patients with single segmental cervical disc herniation were treated in our hospital. Of them, 26 received Discover ACDF (arthroplasty group) and 35 underwent single-level ACDF (fusion group). Visual analogue scale (VAS) neck/arm pain score, Japanese Orthopedics Association (JOA) score and flexion-exten-sion range of motion of operative and adjacent segments were evaluated preoperatively and 1 week and 3, 6, 12, and 24 months postoperatively. Complications and secondary treatment were recorded. Results:A total of 52 patients (29 in arthroplasty group and 23 in fusion group) were followed up. The average follow-up pe-riod was 15.3 months (range, 12-24 months). The VAS scores of neck pain and upper limb pain and JOA score were signifi-cantly improved during follow up as compared with preoperative ones in all patients (P0.05). In arthroplasty group, there was no significant difference in range of motion of opera-tive and adjacent segments before and after treatment (P>0.05). The rate of fusion achievement was 90.5%. In arthroplasy group, prosthesis antedisplacement (<3 mm) in 2 patients at 6 months after surgery, and cerebrospinal fluid leakage oc-curred 1 patient. In fusion group, adjacent segment disease occurred in one patient who underwent secondary operation. Conclusions:Discover cervical disc replacement is a feasible alternative to ACDF for patients with persistent symptomatic cervical disc

  6. Prediction of bioactive compounds activity against wood contaminant fungi using artificial neural networks

    OpenAIRE

    Vicente, Henrique; Roseiro, José C.; Arteiro, José M.; Neves, José; Caldeira, A. Teresa

    2013-01-01

    Biopesticides based on natural endophytic bacteria to control plant diseases are an ecological alternative to the chemical treatments. Bacillus species produce a wide variety of metabolites with biological activity like iturinic lipopeptides. This work addresses the production of biopesticides based on natural endophytic bacteria, isolated from Quercus suber. Artificial Neural Networks were used to maximize the percentage of inhibition triggered by antifungal activity of bioactive compounds p...

  7. Prediction Model of Antibacterial Activities for Inorganic Antibacterial Agents Based on Artificial Neural Networks

    Institute of Scientific and Technical Information of China (English)

    刘雪峰; 张利; 涂铭旌

    2004-01-01

    Quantitatively evaluation of antibacterial activities of inorganic antibacterial agents is an urgent problem to be solved. Using experimental data by an orthogonal design, a prediction model of the relation between conditions of preparing inorganic antibacterial agents and their antibacterial activities has been developed. This is accomplished by introducing BP artificial neural networks in the study of inorganic antibacterial agents..It provides a theoretical support for the development and research on inorganic antibacterial agents.

  8. A Flexible Approach for Human Activity Recognition Using Artificial Hydrocarbon Networks

    Directory of Open Access Journals (Sweden)

    Hiram Ponce

    2016-10-01

    Full Text Available Physical activity recognition based on sensors is a growing area of interest given the great advances in wearable sensors. Applications in various domains are taking advantage of the ease of obtaining data to monitor personal activities and behavior in order to deliver proactive and personalized services. Although many activity recognition systems have been developed for more than two decades, there are still open issues to be tackled with new techniques. We address in this paper one of the main challenges of human activity recognition: Flexibility. Our goal in this work is to present artificial hydrocarbon networks as a novel flexible approach in a human activity recognition system. In order to evaluate the performance of artificial hydrocarbon networks based classifier, experimentation was designed for user-independent, and also for user-dependent case scenarios. Our results demonstrate that artificial hydrocarbon networks classifier is flexible enough to be used when building a human activity recognition system with either user-dependent or user-independent approaches.

  9. Artificial activation of mature unfertilized eggs in the malaria vector mosquito, Anopheles stephensi (Diptera, Culicidae).

    Science.gov (United States)

    Yamamoto, Daisuke S; Hatakeyama, Masatsugu; Matsuoka, Hiroyuki

    2013-08-01

    In the past decade, many transgenic lines of mosquitoes have been generated and analyzed, whereas the maintenance of a large number of transgenic lines requires a great deal of effort and cost. In vitro fertilization by an injection of cryopreserved sperm into eggs has been proven to be effective for the maintenance of strains in mammals. The technique of artificial egg activation is a prerequisite for the establishment of in vitro fertilization by sperm injection. We demonstrated that artificial egg activation is feasible in the malaria vector mosquito, Anopheles stephensi (Diptera, Culicidae). Nearly 100% of eggs dissected from virgin females immersed in distilled water darkened, similar to normally oviposited fertilized eggs. It was revealed by the cytological examination of chromosomes that meiotic arrest was relieved in these eggs approximately 20 min after incubation in water. Biochemical examinations revealed that MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated protein kinase) and MEK (MAPK/ERK kinase) were dephosphorylated similar to that in fertilized eggs. These results indicate that dissected unfertilized eggs were activated in distilled water and started development. Injection of distilled water into body cavity of the virgin blood-fed females also induced activation of a portion of eggs in the ovaries. The technique of artificial egg activation is expected to contribute to the success of in vitro fertilization in A. stephensi.

  10. A Flexible Approach for Human Activity Recognition Using Artificial Hydrocarbon Networks.

    Science.gov (United States)

    Ponce, Hiram; Miralles-Pechuán, Luis; Martínez-Villaseñor, María de Lourdes

    2016-10-25

    Physical activity recognition based on sensors is a growing area of interest given the great advances in wearable sensors. Applications in various domains are taking advantage of the ease of obtaining data to monitor personal activities and behavior in order to deliver proactive and personalized services. Although many activity recognition systems have been developed for more than two decades, there are still open issues to be tackled with new techniques. We address in this paper one of the main challenges of human activity recognition: Flexibility. Our goal in this work is to present artificial hydrocarbon networks as a novel flexible approach in a human activity recognition system. In order to evaluate the performance of artificial hydrocarbon networks based classifier, experimentation was designed for user-independent, and also for user-dependent case scenarios. Our results demonstrate that artificial hydrocarbon networks classifier is flexible enough to be used when building a human activity recognition system with either user-dependent or user-independent approaches.

  11. In vitro maturation and artificial activation of donkey oocytes.

    Science.gov (United States)

    Zhao, Gaoping; Wu, Kaifeng; Cui, Liang; Zhao, Lixia; Liu, Yiyi; Tan, Xiuwen; Zhou, Huanmin

    2011-09-01

    Three media were evaluated for their ability to support in vitro maturation of donkey (Equus asinus) oocytes and their development after parthenogenetic activation. The basal medium for Medium 1 (M1) and Medium 2 (M2) was M199 and DMEM/F12 respectively, whereas, Medium 3 (M3) consisted of equal parts (v/v) of M199 and DMEM/F12. All three media were supplemented with 10% (v/v) fetal calf serum, 0.01 units/mL porcine FSH, 0.01 units/mL equine LH, 200 ng/mL insulin-like growth factor 1(IGF-I), 10 μl/mL insulin-transferrin-selenium (ITS), 0.1 mg/mL taurine, 0.1 mg/mL L-cysteine, 0.05 mg/mL L-glutamine, 0.11 mg/mL sodium pyruvate, and 25 mg/mL gentamycin. There were no significant differences among the three maturation media for oocyte maturation. Maturation rate of donkey oocytes in M1 was 53% for compact (Cp) cumulus-oocyte complexes and 75% for expanded (Ex) cumulus-oocyte complexes; in M2 these were 55 and 77%, respectively; and in M3, 58 and 75%. The percentage of cleaved parthenotes and 4- or 8-cell embryos were not significantly different for oocytes matured in the various media (61 and 24% for M1; 66 and 32% for M2; and 67 and 33% for M3). Oocytes matured in M3 tended to yield a higher rate of advanced embryo development (morula) than oocytes matured in M1 (22 vs 9%; P = 0.07). In conclusion, donkey oocytes were matured and parthenogenetically activated in vitro, using methods similar to those used in the horse.

  12. Proximal caries detection using digital subtraction radiography in the artificial caries activity model

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Hoon; Lee, Gi Ja; Choi, Sam Jin; Park, Young Ho; Kim, Kyung Soo; Jin, Hyun Seok; Hong, Kyung Won; Oh, Berm Seok; Park, Hun Kuk [Department of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul (Korea, Republic of); Choi, Yong Suk; Hwang, Eui Hwan [Department of Oral and Maxillofacial Radiology, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul (Korea, Republic of)

    2009-03-15

    The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Digital radiographs of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size no.2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. In artificial caries activity model, the range of lesional depth was 572-1,374 {mu}m and the range of lesional area was 36.95-138.52 mm{sup 2}. The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.

  13. 人工腰椎间盘假体位置对活动度的影响%Effect of intervertebral position on range of motion after artificial lumbar total disc replacement and clinical management

    Institute of Scientific and Technical Information of China (English)

    刘艳成; 宁尚龙; 杨强; 夏群; 张继东; 徐宝山; 胡永成; 吉宁; 苗军; 白剑强; 韩岳

    2010-01-01

    Objective To discuss the effect of SB Charité lumbar artificial disc position on intervertebral range of motion(ROM)and clinical management.Methods Between 2004 and 2007, 30 discogenic low back pain patients confirmed by discography underwent 1/2-level total disc replacement (TDR)implantation with 32 prostheses.There were 12 males and 18 females with a mean age of 44 years old (range:28-55).All indexed levels were inserted between L4-S1 involving L4-5(n =9), L5S1(n = 19)and L4-S1(n =2).The clinical outcome was measured by Oswestry disability index(ODI)and visual analogue scale(VAS).Radiographic outcome measures included flexion/extension ROM, restoration of operative level intervertebral disc height, maintenance of disc height at the final follow-up.A technique previously described by McAfee was used to evaluate TDR position in three groups.Paired t test was used to compare the preoperative and postoperative ROM and clinical ODI, VAS scores.Results Twenty-eight patients were followed-up for 24-60 months with an average of 38 months.All the prostheses were solidly immobilized with the vertebral endplate.No disc prosthesis rupture, dislocation, subsidence or heterotopic ossification was observed.Preoperative ODI, VAS back pain and VAS leg pain scores were 70.34 ± 9.21, 7.46 ± 2.65,4.81 ± 2.75;and postoperative corresponding scores 7.65 ± 8.61, 0.68 ± 0.69, 0.35 ± 0.32respectively.The positions of disc prostheses were graded as Group Ⅰ , excellent, n = 17;Group Ⅱ,suboptimal, n = 6;Group Ⅲ, poor, n = 5.Preoperative mean intervertebral flexion/extension ROM (degree)of Group Ⅰ to Group Ⅲ were 9.75 ± 2.80, 10.30 ± 1.20 and 10.08 ± 2.43 respectively.The postoperative mean intervertebral flexion/extension ROM(degree): 6.68 ± 3.83, 4.22 ± 3.51 and 3.48 ± 3.56 respectively.Postoperatively all clinical outcome scores were lower than preoperative ones.Disc height was significantly restored.Mean intervertebral ROM decreased versus preoperative

  14. Investigation of the oxygen reduction activity on silver - a rotating disc electrode study

    Energy Technology Data Exchange (ETDEWEB)

    Wiberg, G.K.H.; Mayrhofer, K.J.J.; Arenz, M. [Lehrstuhl fuer Physikalische Chemie, Technische Universitaet Muenchen, D-85748 Garching (Germany)

    2010-08-15

    In this study the oxygen reduction reaction (ORR) is investigated on a nanoparticulate silver electrocatalyst in alkaline solution. The catalytic activity of the catalyst is determined both in terms of mass activity as well as specific activity and turn over frequency, respectively. It is demonstrated that the established mass activities are independent of the applied catalyst loading, an essential requirement for a reasonable analysis. The determination of the electrochemically active surface area (ECA) or the number of electrochemically accessible sites (N{sub ECAS}), respectively, is performed by the underpotential deposition of lead. The obtained value of the activity is compared to activities of polycrystalline silver and platinum measured in the same electrolyte, as well as to literature data. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  15. Broken discs: warp propagation in accretion discs

    OpenAIRE

    Nixon, Chris; King, Andrew

    2012-01-01

    We simulate the viscous evolution of an accretion disc around a spinning black hole. In general any such disc is misaligned, and warped by the Lense-Thirring effect. Unlike previous studies we use effective viscosities constrained to be consistent with the internal fluid dynamics of the disc. We find that nonlinear fluid effects, which reduce the effective viscosities in warped regions, can promote the breaking of the disc into two distinct planes. This occurs when the Shakura & Sunyaev dimen...

  16. Self-gravitating accretion discs

    OpenAIRE

    Lodato, G.

    2008-01-01

    I review recent progresses in the dynamics and the evolution of self-gravitating accretion discs. Accretion discs are a fundamental component of several astrophysical systems on very diverse scales, and can be found around supermassive black holes in Active Galactic Nuclei (AGN), and also in our Galaxy around stellar mass compact objects and around young stars. Notwithstanding the specific differences arising from such diversity in physical extent, all these systems share a common feature whe...

  17. Curative effect evaluation and complication analysis of Bryan artificial cervical disc replacement%Bryan人工颈椎间盘置换术后疗效评价及并发症分析

    Institute of Scientific and Technical Information of China (English)

    蓝旭; 许建中; 刘雪梅; 葛宝丰

    2013-01-01

    To observe the curative effects and complications nf Bryan cervical disc replacement for cervical disc herniation. Methods:From Jannary 2005 to December 2008,39 patients with cervical disc herniation were treated with Bryan cervical disc replacement. There were 20 males and 19 females,with an average age of 47 years old (ranged ,35 to 59). Spinal compression symptom (20 cases) and nerve root symptom (19 eases) were main clinical symptoms. Single level disc was replaced in 35 cases and two-level replaced in 4 cases. Offset and activity of prosthesis, cervical physiological curvature, heterotopic ossification, prosthetic fusion were observed by dynamic X-ray. According to Odom's standard and JOA score, nerve function were evaluated;and depending on NDI standard,clinical symptom and daily function status were recorded. Results: All the patients were followed up from 16 to 36 months with an average of 24 months. Nerve function obviously improved and radiating pain of upper limb completely relieved. No patient with prosthetic anterior-posterior offset more than 2 mm was found. Prosthetic flexion and extention angle was(8.5±1.8)°,left and right flexion range respectively were (3.5±1.2)° and (3.3±1.5)°. Cervical physiological curvature improved obviously or recovered normally. Three cases occurred in heterotopic ossification and 2 cases occurred in prosthetic fusion. According to Odom's standard,25 cases got an excellent results,9 good,5 fair,the rate of excellent and good was 87.2%. JOA score increased from preoperative(8.26±1.32) to (15.71±1.89) at final follow-up and NDI decreased from preoperative (43.7±3.8) to (20.1±2.9) at final follow-up. Conclusion: Treatment of cervical disc herniation with Bryan cervical disc replacement can get the good curative effects,which can obtain good nerve functional recovery,cervical stability and activity. Nevertheless, the operation has typical complication such as heterotopic ossification and prosthetic fusion. Thus.it is

  18. Gene expression of fibrinolytic factors urokinase plasminogen activator and plasminogen activator inhibitor-1 in rabbit temporo-mandibular joint cartilage with disc displacement

    Institute of Scientific and Technical Information of China (English)

    ZHAN Jing; GU Zhi-yuan; WU Li-qun; ZHANG Yin-kai; HU Ji-an

    2005-01-01

    Background The urokinase plasminogen activator system is believed to play an important role in degradation of the extracellular matrix associated with cartilage and bone destruction; however its precise roles in temporomandibular disorders have not yet been clarified. The aims of this study were to investigate the gene expression of fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in the articular cartilage of rabbit temporomandibular joint (TMJ) with disc displacement (DD) and to probe the relationship between fibrinolytic activity and cartilage remodeling. Methods Disc displacement of right joints was performed in 36 of 78 rabbits under investigation. The animals were sacrificed at 4 days and 1, 2, 4, 8 and 12 weeks after surgery, respectively. The right joints of these animals were harvested and processed for the examination of mRNA expression of uPA and PAI-1 in articular cartilage using in situ hybridization techniques. Results The expression of uPA and PAI-1 was co-expressed weakly in the chondrocytes from transitive zone to hypertrophic zone and mineralized zone, while no hybridizing signals were shown in proliferative zone and superficial zone in control rabbits. The most striking was the up-regulation of uPA and PAI-1 mRNA in 4-day rabbits postoperatively at the onset of cartilage degeneration. The strongest hybridizing signals for uPA and PAI-1 were seen in 2-week rabbits postoperatively. After 2 weeks, the expression of uPA and PAI-1 began to decrease and reached nearly normal level at 12 weeks. Conclusions The expression of the uPA/PAI-1 system coincides with the pathological changes in condylar cartilage after DD. The uPA/PAI-1 system may be one of the essential mediators in articular cartilage remodeling.

  19. Observation of short-term curative effect of multi-segmental anterior cervical artificial disc replacement under microscope%显微技术下前路多节段颈椎人工椎间盘置换术短期疗效观察

    Institute of Scientific and Technical Information of China (English)

    龙勇; 冯海龙

    2015-01-01

    目的:探讨显微镜下多节段颈椎人工椎间盘置换术的短期疗效,观察术后颈椎活动度及临床功能的变化,为多节段颈椎间盘突出症的外科治疗提供临床依据。方法因颈椎病( cervical spondylosis,CS)行显微镜下多节段颈椎人工椎间盘置换术患者,其中使用颈椎动态稳定器DCI 2例,使用Prestige-LP人工椎间盘3例。患者术前与术后6月均行颈椎正侧位、过伸过屈位X射线片、颈椎MRI检查,测量脊髓功能评分(JOA)和置换节段活动度(range of motion,ROM)。结果显微镜下微创手术未出现手术并发症,神经功能明显改善;术后6月颈椎运动范围与术前比较差异无统计学意义( P>0.05);所有患者的JOA评分较术前均有明显改善( P<0.05)。结论显微镜下手术创伤小,并发症少,多节段颈椎人工椎间盘置换术基本保留了颈椎的稳定性,具有良好的活动度,短期临床效果良好。%Objective To investigate the short-term curative effect of multiple segmental cervical artificial disc replacement ( msCDR) under microscope and observe the changes of postoperative cervical activity and clinical features in order to provide prelimi-nary clinical basis for surgical treatment of the disease.Methods A retrospective analysis of 5 cases of cervical spondylosis treated with microsurgical msCDR,including 2 cases with cervical dynamic implant(DCI)and 3 cases with artificial cervical disc(Prestige-LP) ,was performed.Data included the cervical motion X-ray, cervical MRI, JOA score evaluation and motion of replacement discs ( Range of motion,ROM) before and after 6 months of surgery.Results Minimally invasive surgery under the microscopic manipula-tions has less operative complications compared with“naked-eye” surgery.Neuro-function was significantly improved.The cervical mo-tion after 6 months of operation showed no significant difference when compared to pre

  20. A Novel Wearable Sensor-Based Human Activity Recognition Approach Using Artificial Hydrocarbon Networks

    Directory of Open Access Journals (Sweden)

    Hiram Ponce

    2016-07-01

    Full Text Available Human activity recognition has gained more interest in several research communities given that understanding user activities and behavior helps to deliver proactive and personalized services. There are many examples of health systems improved by human activity recognition. Nevertheless, the human activity recognition classification process is not an easy task. Different types of noise in wearable sensors data frequently hamper the human activity recognition classification process. In order to develop a successful activity recognition system, it is necessary to use stable and robust machine learning techniques capable of dealing with noisy data. In this paper, we presented the artificial hydrocarbon networks (AHN technique to the human activity recognition community. Our artificial hydrocarbon networks novel approach is suitable for physical activity recognition, noise tolerance of corrupted data sensors and robust in terms of different issues on data sensors. We proved that the AHN classifier is very competitive for physical activity recognition and is very robust in comparison with other well-known machine learning methods.

  1. 颈椎人工椎间盘置换与颈前路减压融合术术后轴性症状的分析%The analysis of neck axial symptoms analysis after cervical artificial disc replacement and anterior cervical decompression and fusion

    Institute of Scientific and Technical Information of China (English)

    张杨; 王利民

    2013-01-01

    ,including 21 males and 25 females,with an average age of 51.6 years.Forty patients (ADR group) underwent cervical artificial disc replacement,including 18 males and 22 females,with an average age of 49.1 years.Through the observation of JOA scores,the satisfactory rate of Odom ' s scale,cervical curvature index(CCI),and the changes of cervical range of motion (ROM) of the two groups,to compare the incidence of neck AS of the two groups and analyzed the outcomes.Results All patients were followed up for 6 to 24 months,15.2 months on average.The patients' JOA scores at the postoperative follow-up increased obviously than preoperative (P < 0.05).The satisfactory rate of Odom' s scale at 3,6 months and the final follow-up after operation showed no significant difference between the ACDF group and ADR group (P > 0.05).In ACDF group,there was a significant loss of postoperative cervical curvature compared with preoperative (P < 0.05),and there was no significant loss of the postoperative cervical curvature compared with preoperative (P > 0.05) ; In ACDF group,the postoperative cervical ROM compared with preoperative reduced significantly (P < 0.05),while the ADR group showed no significant difference (P > 0.05).In ACDF group,the rate of postoperative AS was 47.83%,while 20.00% in ADR group,it showed a significant difference between the two groups (P >0.05).Conclusions The artificial disc replacement can preserve cervical lordosis and cervical ROM,increase the activities of the adjacent segments,and do not need to wear a neck collar,and patients can exercise early,so it will reduce the occurrence of postoperative AS effectively.

  2. Accelerometer signal-based human activity recognition using augmented autoregressive model coefficients and artificial neural nets.

    Science.gov (United States)

    Khan, A M; Lee, Y K; Kim, T S

    2008-01-01

    Automatic recognition of human activities is one of the important and challenging research areas in proactive and ubiquitous computing. In this work, we present some preliminary results of recognizing human activities using augmented features extracted from the activity signals measured using a single triaxial accelerometer sensor and artificial neural nets. The features include autoregressive (AR) modeling coefficients of activity signals, signal magnitude areas (SMA), and title angles (TA). We have recognized four human activities using AR coefficients (ARC) only, ARC with SMA, and ARC with SMA and TA. With the last augmented features, we have achieved the recognition rate above 99% for all four activities including lying, standing, walking, and running. With our proposed technique, real time recognition of some human activities is possible.

  3. Dishevelled binds the Discs large 'Hook' domain to activate GukHolder-dependent spindle positioning in Drosophila.

    Directory of Open Access Journals (Sweden)

    Joshua D Garcia

    Full Text Available Communication between cortical cell polarity cues and the mitotic spindle ensures proper orientation of cell divisions within complex tissues. Defects in mitotic spindle positioning have been linked to various developmental disorders and have recently emerged as a potential contributor to tumorigenesis. Despite the importance of this process to human health, the molecular mechanisms that regulate spindle orientation are not fully understood. Moreover, it remains unclear how diverse cortical polarity complexes might cooperate to influence spindle positioning. We and others have demonstrated spindle orientation roles for Dishevelled (Dsh, a key regulator of planar cell polarity, and Discs large (Dlg, a conserved apico-basal cell polarity regulator, effects which were previously thought to operate within distinct molecular pathways. Here we identify a novel direct interaction between the Dsh-PDZ domain and the alternatively spliced "I3-insert" of the Dlg-Hook domain, thus establishing a potential convergent Dsh/Dlg pathway. Furthermore, we identify a Dlg sequence motif necessary for the Dsh interaction that shares homology to the site of Dsh binding in the Frizzled receptor. Expression of Dsh enhanced Dlg-mediated spindle positioning similar to deletion of the Hook domain. This Dsh-mediated activation was dependent on the Dlg-binding partner, GukHolder (GukH. These results suggest that Dsh binding may regulate core interdomain conformational dynamics previously described for Dlg. Together, our results identify Dlg as an effector of Dsh signaling and demonstrate a Dsh-mediated mechanism for the activation of Dlg/GukH-dependent spindle positioning. Cooperation between these two evolutionarily-conserved cell polarity pathways could have important implications to both the development and maintenance of tissue homeostasis in animals.

  4. Chewing insect predation on artificial caterpillars is related to activity density of ground beetles (Coleoptera: Carabidae)

    DEFF Research Database (Denmark)

    Ferrante, M.; Lövei, G. L.

    2015-01-01

    , easy to use, and are informative about predator identity. In a field experiment in Denmark, performed between May and July 2014, we tested the relationship between predation rate measured using artificial caterpillars and the activity density of large (≥15mm) ground beetles collected using pitfall...... predation rate by ground beetles, and that the method is partially informative on the relationship between predators and predation.......In cultivated landscapes, predatory arthropods play an important role for pest control. Traditionally, monitoring their effect on pests was done using indirect measures (e.g. characterising predator activity by the numbers of predators caught). However, the contribution of predators to predation...

  5. Application of Artificial Intelligence to the Prediction of the Antimicrobial Activity of Essential Oils.

    Science.gov (United States)

    Daynac, Mathieu; Cortes-Cabrera, Alvaro; Prieto, Jose M

    2015-01-01

    Essential oils (EOs) are vastly used as natural antibiotics in Complementary and Alternative Medicine (CAM). Their intrinsic chemical variability and synergisms/antagonisms between its components make difficult to ensure consistent effects through different batches. Our aim is to evaluate the use of artificial neural networks (ANNs) for the prediction of their antimicrobial activity. Methods. The chemical composition and antimicrobial activity of 49 EOs, extracts, and/or fractions was extracted from NCCLS compliant works. The fast artificial neural networks (FANN) software was used and the output data reflected the antimicrobial activity of these EOs against four common pathogens: Staphylococcus aureus, Escherichia coli, Candida albicans, and Clostridium perfringens as measured by standardised disk diffusion assays. Results. ANNs were able to predict >70% of the antimicrobial activities within a 10 mm maximum error range. Similarly, ANNs were able to predict 2 or 3 different bioactivities at the same time. The accuracy of the prediction was only limited by the inherent errors of the popular antimicrobial disk susceptibility test and the nature of the pathogens. Conclusions. ANNs can be reliable, fast, and cheap tools for the prediction of the antimicrobial activity of EOs thus improving their use in CAM.

  6. 单节段颈椎人工椎间盘置换与前路椎间融合内固定:维持颈椎活动度和稳定性的比较%Single level artificial disc replacement versus anterior cervical fusion:range of motion and stability of cervical vertebra

    Institute of Scientific and Technical Information of China (English)

    王威; 王利民; 王卫东; 谭洪宇; 刘屹林; 张书豪

    2014-01-01

    BACKGROUND:Fusion treatment for single segment cervical spondylosis can induce complications such as abnormal enlargement of range of motion in adjacent segments and degenerative manifestations. Recently, scholars began to explore and to use non-fusion technique to replace traditional fusion therapy. Cervical artificial disc replacement as a new anterior non-fusion program has been greatly used in the clinic, not only obtained good clinical therapeutic effects, but also made cervical vertebrae near physiological stability, delayed adjacent segment degeneration and reduced complications. OBJECTIVE:To compare the clinical effects of the single level artificial disc replacement and the anterior cervical decompression and fusion for cervical spondylosis. METHODS:A total of 59 patients with single segment cervical spondylosis, whose clinical signs and symptoms were accorded, were enrol ed from the First Affiliated Hospital of Zhengzhou University, China from May 2011 to May 2013. Imaging revealed that single segment of cervical disc degeneration compressed spinal cord or nerve root. Owing to different surgeries, these patients were divided into artificial disc replacement group (replacement group;n=32) and anterior cervical decompression and fusion group (fusion group;n=27). They were fol owed up at 5 days, 3, 6 and 12 months after treatment. Japanese Orthopaedic Association scores, neck pain, upper extremity pain visual analog scale scores were measured. The range of motion of the replacement segment and its effects on adjacent segments were observed. RESULTS AND CONCLUSION:The postoperative Japanese Orthopaedic Association Scores were improved compared with preoperative scores (P0.05). Range of motion of the replacement segment after treatment was (11.6±3.0)° in the replacement group, showing no significant differences as compared with before surgery (8.8±2.7)° (P>0.05). No significant activity was found at 3 months after treatment in the fusion group. During fol

  7. Analysis of mid-long term clinical efficacy and complications of Bryan artificial cervical disc replacement%Bryan人工颈椎椎间盘置换术后中长期临床疗效及相关问题分析

    Institute of Scientific and Technical Information of China (English)

    蒋涛; 任先军; 王卫东; 初同伟; 李长青

    2011-01-01

    目的 探讨Bryan人工颈椎椎间盘置换术(artificial cervical disc replacement,ACDR)治疗颈椎椎间盘突出症的中长期临床疗效及并发症发生情况.方法 回顾分析13例颈椎椎间盘突出症患者,采用Bryan ACDR治疗,单节段11例,双节段2例,共置换了15个节段.术后定期随访,依照Odom评级和日本骨科学会(Japanese Orthopaedic Association,JOA)评分评定临床疗效和神经功能改善情况,通过影像学资料观察假体位移、假体周围骨吸收、异位骨化、假体活动度及颈椎生理曲度变化.结果 经过5年以上的随访,患者神经症状有明显缓解,Odom评级临床优良率达到92.3%,JOA评分由术前的11.6分增加到的15.6分.术后X线片示假体稳定,没有出现假体前后位移>2mm.术后1例出现自发性融合;1例在置换节段上位椎体前下缘有明显骨吸收,接近2.5mm,并伴椎体后缘的异位骨化.末次随访时置换假体活动度平均为9.2°,邻近节段活动度与术前相当.结论 通过5~7年的中长期随访,Bryan ACDR术治疗颈椎椎间盘突出症具有较好的临床疗效,并发症少,安全可靠.%Objective To evaluate the mid-long term clinical efficacy and complications of Bryan artificial cervical arthro-plasty replacement (ACDR) for treatment of cervical disc herniation. Methods Thirteen cases of cervical disc herniation were retrospectively analyzed. A total of 15 sets of Bryan cervical disc prosthesis were implanted into 13 cases, including single level disc replacement in 11 cases and bi-level in 2 cases. During follow-up, the clinical efficacy and neurological function were evaluated by Odom's criteria and Japanese Orthopaedic Association (JOA)score; the mobility, resorption, heteropic ossification, physiological lordosis and range of motion of the implanted and adjacent segment were observed on dynamic radiograph. Results After more than 5 years of follow-up, all cases showed significant improvement in neurological

  8. Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

    Directory of Open Access Journals (Sweden)

    Kentaro Hozumi

    2015-02-01

    Full Text Available The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane.

  9. In vitro fertilization and artificial activation of eggs of the direct-developing anuran Eleutherodactylus coqui

    Directory of Open Access Journals (Sweden)

    Toro Esteban

    2004-08-01

    Full Text Available Abstract Although much is known about the reproductive biology of pond-breeding frogs, there is comparatively little information about terrestrial-breeding anurans, a highly successful and diverse group. This study investigates the activation and in vitro fertilization of eggs of the Puerto Rican coqui frog obtained by hormonally induced ovulation. We report that spontaneous activation occurs in 34% of eggs, probably in response to mechanical stress during oviposition. Artificial activation, as evidenced by the slow block to polyspermy and the onset of zygote division, was elicited both by mechanical stimulation and calcium ionophore exposure in 64% and 83% of the cases, respectively. Finally, one in vitro fertilization protocol showed a 27% success rate, despite the fact that about one third of all unfertilized eggs obtained by hormone injection auto-activate. We expect these findings to aid in the conservation effort of Eleutherodactylus frogs, the largest vertebrate genus.

  10. Application of an artificial neural network for evaluation of activity concentration exemption limits in NORM industry.

    Science.gov (United States)

    Wiedner, Hannah; Peyrés, Virginia; Crespo, Teresa; Mejuto, Marcos; García-Toraño, Eduardo; Maringer, Franz Josef

    2016-12-27

    NORM emits many different gamma energies that have to be analysed by an expert. Alternatively, artificial neural networks (ANNs) can be used. These mathematical software tools can generalize "knowledge" gained from training datasets, applying it to new problems. No expert knowledge of gamma-ray spectrometry is needed by the end-user. In this work an ANN was created that is able to decide from the raw gamma-ray spectrum if the activity concentrations in a sample are above or below the exemption limits.

  11. 人工椎间盘置换术治疗跳跃型多节段颈椎病的中期疗效%Comparison of the mid-term follow-up results between treatment of Bryan cervical artificial disc replacement and ante-rior cervical decompression and fusion for"skip"cervical spondylosis

    Institute of Scientific and Technical Information of China (English)

    尚子琨; 张英泽; 张迪; 丁文元; 张为; 孟宪中; 王林峰; 申勇

    2014-01-01

    Objective To retrospectively analysis and compareabout Bryan artificial cervical disc arthroplasty with ante-rior cervical decompression and fusion (ACDF) on the clinical efficacy for“Skip”cervical spondylosis. Methods From February 2002 to May 2012, 49 cases were treated with Bryan artificial cervical disc arthroplasty (artificial cervical disc replacement surgery group, 18 cases) or anterior cervical decompression and fusion (ACDF group, 31 cases), 29 males and 20 females. Each case was evaluated at the moment of preoperatively, 3 months, 6 and 12 months and last follow-up after surgery by the Japanese Orthopedic Association (JOA), Neck Disability Index (NDI), Visual Analog Scale (VAS), Cervical sagittal curvature, the total cervical spine range of motion(ROM),middle segments of motion. MRI was also used to assess to adjacent segment disc degeneration, spinal cord compression and signal change situation. Results All patients were followed up for more than 24 months. The score of the JOA, NDI, VAS in the two groups of patients improved significantly after surgery than before surgery. In addition, the VAS score in last follow-up were significantly different between the two groups, but other index each time in the two groups showed no significant difference. In last follow-up, the result of artificial cervical disc arthroplasty group were better than ACDF group on the incidence of axial symptoms, the total cervical spine range of motion (ROM) and middle segments of motion. The incidence of axial symptoms in artificial cervical disc arthroplasty group were 11.1%,ACDF group were 45.2%. ROM in arti-ficial cervical disc arthroplasty group were 35.5°±5.9°,ACDF group were 24.5°±6.2°. Middle segments of motion in artificial cer-vical disc arthroplasty group were 7.3°±1.4°,ACDF group were 10.1°±1.6°. The above comparison of the datas were statistically different. There are two cases of adjacent segment degeneration in ACDF group without need to surgery

  12. Prodisc-C人工颈椎椎间盘置换的临床疗效观察和运动功能评估%Clinical efficiency and motor function assessment of Prodisc-C artificial cervical disc replacement

    Institute of Scientific and Technical Information of China (English)

    陈道森; 施荣茂; 周强; 罗飞; 代飞; 张劲松; 许建中

    2011-01-01

    目的 通过术后随访评价Prodisc-C人工颈椎椎间盘置换术(artificial cervical disc replacement,ACDR)治疗颈椎病的临床疗效及其对颈椎置换节段、邻近节段运动功能的影响.方法 回顾性分析2009年8月~2011年2月行Prodisc-C ACDR治疗20例颈椎病患者,其中脊髓型9例、神经根型8例、混合型3例,单椎间盘置换17例、双椎间盘置换3例.患者术前行CT、MRI检查明确诊断,术前和术后定期行疼痛视觉模拟量表(visual analogue scale,VAS)和日本骨科学会(Japanese Orthopaedic Association,JOA)及摄颈椎X线片.结果 13例患者获得6~18个月随访.患者术前颈肩背疼痛、上下肢麻木、肌力减弱等不适症状均明显改善.术后VAS及JOA评分均较术前明显改善,差异有统计学意义(P<0.01);置换节段椎间活动度( range of motion,ROM)在术后1、3、6个月显著增大,与术前相比差异有统计学意义(P<0.01);在末次随访时仍大于术前,差异有统计学意义(P<0.05);上下位邻近节段椎间隙高度和椎间ROM与术前相比,差异无统计学意义(P>0.05).所有病例未见假体松动、移位和异位骨化.结论 Prodisc-C ACDR短期随访疗效优良,置换节段ROM增大,邻近节段椎间隙高度和椎间ROM维持在正常水平,但远期疗效还有待进一步随访观察.%Objective To evaluate the clinical efficacy of artificial cervical disc replacement (ACDR) with Prodisc-C and its effects on the motor function of the replaced level and adjacent segments. Methods A total of 20 patients who received ACDR with Prodisc-C from April 2009 to February 2011 were retrospectively analyzed. There were 9 patients with myelopathy, 8 with radiculopa-thy, and the left 3 with both symptoms. There were 17 participators received single level replacement, and the other 3 had 2 levels replaced. All the patients received CT and MRI preoperatively for accurate diagnosis. Visual analogue scale ( VAS) scores for neck and arm

  13. Measuring riboswitch activity in vitro and in artificial cells with purified transcription-translation machinery.

    Science.gov (United States)

    Martini, Laura; Mansy, Sheref S

    2014-01-01

    We present a simple method to measure the real-time activity of riboswitches with purified components in vitro and inside of artificial cells. Typically, riboswitch activity is measured in vivo by exploiting β-galactosidase encoding constructs with a putative riboswitch sequence in the untranslated region. Additional in vitro characterization often makes use of in-line probing to explore conformational changes induced by ligand binding to the mRNA or analyses of transcript lengths in the presence and absence of ligand. However, riboswitches ultimately control protein levels and often times require accessory factors. Therefore, an in vitro system capable of monitoring protein production with fully defined components that can be supplemented with accessory factors would greatly aid riboswitch studies. Herein we present a system that is amenable to such analyses. Further, since the described system can be easily reconstituted within compartments to build artificial, cellular mimics with sensing capability, protocols are provided for building sense-response systems within water-in-oil emulsion compartments and lipid vesicles. Only standard laboratory equipment and commercially available material are exploited for the described assays, including DNA, purified transcription-translation machinery, i.e., the PURE system, and a spectrofluorometer.

  14. Artificial neural network prediction of the psychometric activities of phenylalkylamines using DFT-calculated molecular descriptors

    Directory of Open Access Journals (Sweden)

    MINA HAGHDADI

    2010-10-01

    Full Text Available In the present work, a quantitative structure–activity relationship (QSAR method was used to predict the psychometric activity values (as mescaline unit, log MU of 48 phenylalkylamine derivatives from their density functional theory (DFT calculated molecular descriptors and an artificial neural network (ANN. In the first step, the molecular descriptors were obtained by DFT calculation at the 6-311G level of theory. Then the stepwise multiple linear regression method was employed to screen the descriptor spaces. In the next step, an artificial neural network and multiple linear regressions (MLR models were developed to construct nonlinear and linear QSAR models, respectively. The standard errors in the prediction of log MU by the MLR model were 0.398, 0.443 and 0.427 for training, internal and external test sets, respectively, while these values for the ANN model were 0.132, 0.197 and 0.202, respectively. The obtained results show the applicability of QSAR approaches by using ANN techniques in prediction of log MU of phenylalkylamine derivatives from their DFT-calculated molecular descriptors.

  15. Active Path Selection of Fluid Microcapsules in Artificial Blood Vessel by Acoustic Radiation Force

    Science.gov (United States)

    Masuda, Kohji; Muramatsu, Yusuke; Ueda, Sawami; Nakamoto, Ryusuke; Nakayashiki, Yusuke; Ishihara, Ken

    2009-07-01

    Micrometer-sized microcapsules collapse upon exposure to ultrasound. Use of this phenomenon for a drug delivery system (DDS), not only for local delivery of medication but also for gene therapy, should be possible. However, enhancing the efficiency of medication is limited because capsules in suspension diffuse in the human body after injection, since the motion of capsules in blood flow cannot be controlled. To control the behavior of microcapsules, acoustic radiation force was introduced. We detected local changes in microcapsule density by producing acoustic radiation force in an artificial blood vessel. Furthermore, we theoretically estimated the conditions required for active path selection of capsules at a bifurcation point in the artificial blood vessel. We observed the difference in capsule density at both in the bifurcation point and in alternative paths downstream of the bifurcation point for different acoustic radiation forces. Comparing the experimental results with those obtained theoretically, the conditions for active path selection were calculated from the acoustic radiation force and fluid resistance of the capsules. The possibility of controlling capsule flow towards a specific point in a blood vessel was demonstrated.

  16. Comparison of the mid-term follow-up results between Bryan cervical artificial disc replacement and anterior cervical decompression and fusion for cervical degenerative disc disease%Bryan人工间盘置换与前路减压融合治疗颈椎退行性疾病的中期随访研究

    Institute of Scientific and Technical Information of China (English)

    田伟; 阎凯; 韩骁; 于杰; 靳培浩; 韩晓光

    2013-01-01

    Objective To evaluate the mid-term tollow-up results of cervical artificial disc replacement (CADR) for cervical degenerative disc disease,and to explore whether it can reduce the occurrence of adjacent segment degeneration (ASD).Methods A prospective comparative study of 93 patients who underwent CADR or anterior cervical decompression and fusion (ACDF) for cervical degenerative disc disease were conducted.All patients were followed up for more than 6 years.The Japanese Orthopaedic Association (JOA) score,neck disability index (NDI),Odom's scale,X-rays and magnetic resonance imaging (MRI) were used to evaluate the clinical and radiologic results.Results Twenty eight patients who underwent CADR and 35 patients who underwent ACDF had complete follow-up data.At final follow-up,the JOA score and NDI improved significantly in both groups.Between the two groups,there was no significant difference in terms of JOA score,NDI and Odom's scale.The sagittal alignment was well maintained in both groups.The total cervical spine range of motion (ROM) had no significant change for the CADR group,whereas,it significantly decreased for the ACDF group.The ROM at the replacement level of CADR patients decreased from 9.5° ± 3.7° before operation to 7.0° ± 3.0° 3 months after operation,and it was maintained to 6.6° ± 4.1° at final follow-up without significant decrease.Lateral radiographs and T2-weighted MRI showed the incidence of ASD in CADR group was significantly lower than that in ACDF group.Conclusion The six-year follow-up results of CADR are basically satisfactory.Compared with ACDF,it could better preserve physiological motion and biomechanics of cervical spine,and reduce the incidence of ASD.%目的 评价人工椎间盘置换术治疗颈椎退行性疾病的中期疗效,并探讨其是否可以减少邻近节段退变的发生.方法 前瞻性对比分析接受颈椎人工间盘置换术(置换组,45例)与颈椎前路减压融合术(融合组,48例)治疗的颈椎

  17. Dynamos in accretion discs

    OpenAIRE

    Brandenburg, A.; von Rekowski, B.

    2007-01-01

    It is argued that accretion discs in young stellar objects may have hot coronae that are heated by magnetic reconnection. This is a consequence of the magneto-rotational instability driving turbulence in the disc. Magnetic reconnection away from the midplane leads to heating of the corona which, in turn, contributes to driving disc winds.

  18. Active Vibration Control of the Smart Plate Using Artificial Neural Network Controller

    Directory of Open Access Journals (Sweden)

    Mohit

    2015-01-01

    Full Text Available The active vibration control (AVC of a rectangular plate with single input and single output approach is investigated using artificial neural network. The cantilever plate of finite length, breadth, and thickness having piezoelectric patches as sensors/actuators fixed at the upper and lower surface of the metal plate is considered for examination. The finite element model of the cantilever plate is utilized to formulate the whole strategy. The compact RIO and MATLAB simulation software are exercised to get the appropriate results. The cantilever plate is subjected to impulse input and uniform white noise disturbance. The neural network is trained offline and tuned with LQR controller. The various training algorithms to tune the neural network are exercised. The best efficient algorithm is finally considered to tune the neural network controller designed for active vibration control of the smart plate.

  19. Artificial Neural Networks for Reducing Computational Effort in Active Truncated Model Testing of Mooring Lines

    DEFF Research Database (Denmark)

    Christiansen, Niels Hørbye; Voie, Per Erlend Torbergsen; Høgsberg, Jan Becker

    2015-01-01

    is by active truncated models. In these models only the very top part of the system is represented by a physical model whereas the behavior of the part below the truncation is calculated by numerical models and accounted for in the physical model by active actuators applying relevant forces to the physical...... model. Hence, in principal it is possible to achieve reliable experimental data for much larger water depths than what the actual depth of the test basin would suggest. However, since the computations must be faster than real time, as the numerical simulations and the physical experiment run...... simultaneously, this method is very demanding in terms of numerical efficiency and computational power. Therefore, this method has not yet proved to be feasible. It has recently been shown how a hybrid method combining classical numerical models and artificial neural networks (ANN) can provide a dramatic...

  20. Activity patterns during food provisioning are affected by artificial light in free living great tits (Parus major.

    Directory of Open Access Journals (Sweden)

    Mieke Titulaer

    Full Text Available Artificial light may have severe ecological consequences but there is limited experimental work to assess these consequences. We carried out an experimental study on a wild population of great tits (Parus major to assess the impact of light pollution on daily activity patterns during the chick provisioning period. Pairs that were provided with a small light outside their nest box did not alter the onset, cessation or duration of their working day. There was however a clear effect of artificial light on the feeding rate in the second half of the nestling period: when provided with artificial light females increased their feeding rate when the nestlings were between 9 and 16 days old. Artificial light is hypothesised to have affected the perceived photoperiod of either the parents or the offspring which in turn led to increased parental care. This may have negative fitness consequences for the parents, and light pollution may thus create an ecological trap for breeding birds.

  1. Atomic gas in debris discs

    Science.gov (United States)

    Hales, Antonio S.; Barlow, M. J.; Crawford, I. A.; Casassus, S.

    2017-04-01

    We have conducted a search for optical circumstellar absorption lines in the spectra of 16 debris disc host stars. None of the stars in our sample showed signs of emission line activity in either Hα, Ca II or Na I, confirming their more evolved nature. Four stars were found to exhibit narrow absorption features near the cores of the photospheric Ca II and Na I D lines (when Na I D data were available). We analyse the characteristics of these spectral features to determine whether they are of circumstellar or interstellar origins. The strongest evidence for circumstellar gas is seen in the spectrum of HD 110058, which is known to host a debris disc observed close to edge-on. This is consistent with a recent ALMA detection of molecular gas in this debris disc, which shows many similarities to the β Pictoris system.

  2. INJURIES IN DISC GOLF - A DESCRIPTIVE CROSS-SECTIONAL STUDY

    DEFF Research Database (Denmark)

    Rahbek, Martin Amadeus; Nielsen, Rasmus Oestergaard

    2016-01-01

    BACKGROUND: Disc golf is rapidly increasing in popularity and more than two million people are estimated to regularly participate in disc golf activities. Despite this popularity, the epidemiology of injuries in disc golf remains under reported. PURPOSE: The purpose of the present study was to in...

  3. Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus.

    Science.gov (United States)

    Bedore, Jake; Quesnel, Katherine; Quinonez, Diana; Séguin, Cheryle A; Leask, Andrew

    2016-06-01

    Degeneration of the intervertebral disc (IVD) is a major underlying contributor to back pain-the single leading cause of disability worldwide. However, we possess a limited understanding of the etiology underlying IVD degeneration. To date, there are a limited number of mouse models that have been used to target proteins in specific compartments of the IVD to explore their functions in disc development, homeostasis and disease. Furthermore, the majority of reports exploring the composition and function of the outer encapsulating annulus fibrosus (AF) of the IVD have considered it as one tissue, without considering the numerous structural and functional differences existing between the inner and outer AF. In addition, no mouse models have yet been reported that enable specific targeting of genes within the outer AF. In the current report, we discuss these issues and demonstrate the localized activity of Cre recombinase in the IVD of Col1a2-Cre(ER)T;ROSA26mTmG mice possessing a tamoxifen-dependent Cre recombinase driven by a Cola2 promoter and distal enhancer and the mTmG fluorescent reporter. Following tamoxifen injection of 3-week-old Col1a2-Cre(ER)T;ROSA26mTmG mice, we show Cre activity specifically in the outer AF of the IVD, as indicated by expression of the GFP reporter. Thus, Col1a2-Cre(ER)T;ROSA26mTmG mice may prove to be a valuable tool in delineating the function of proteins in this unique compartment of the IVD, and in further exploring the compositional differences between the inner and outer AF in disc homeostasis, aging and disease.

  4. Data Fusion Using Different Activation Functions in Artificial Neural Networks for Vehicular Navigation

    Directory of Open Access Journals (Sweden)

    MALLESWARAN M,

    2010-12-01

    Full Text Available Global positioning System (GPS and Inertial Navigation System (INS data can be integrated together to provide a reliable navigation. GPS/INS data integration provides reliable navigation solutions by overcoming each of their shortcomings, including signal blockage for GPS and increase in position errors with time for INS. This paper aims to provide GPS/INS data integration utilizing Artificial Neural Network (ANN architecture. This architecture is based on Feed Forward Neural Networks, which generally includes Radial Basis Function (RBF neural network and Back Propagation neural network (BPN. These are systematic methods for training multi-layer artificial networks. The BPN-ANN and RBF-ANN modules are trained to predict the INS position error and provide accurate positioning of the moving vehicle. This paper also compares performance of theGPS/INS data integration system by using different activation function like Bipolar Sigmoidal Function (BPSF, Binary Sigmoidal Function (BISF, Hyperbolic Tangential Function (HTF and Gaussian Function (GF in BPN-ANN and using Gaussian function in RBF-ANN.

  5. Emergence of gamma motor activity in an artificial neural network model of the corticospinal system.

    Science.gov (United States)

    Grandjean, Bernard; Maier, Marc A

    2017-02-01

    Muscle spindle discharge during active movement is a function of mechanical and neural parameters. Muscle length changes (and their derivatives) represent its primary mechanical, fusimotor drive its neural component. However, neither the action nor the function of fusimotor and in particular of γ-drive, have been clearly established, since γ-motor activity during voluntary, non-locomotor movements remains largely unknown. Here, using a computational approach, we explored whether γ-drive emerges in an artificial neural network model of the corticospinal system linked to a biomechanical antagonist wrist simulator. The wrist simulator included length-sensitive and γ-drive-dependent type Ia and type II muscle spindle activity. Network activity and connectivity were derived by a gradient descent algorithm to generate reciprocal, known target α-motor unit activity during wrist flexion-extension (F/E) movements. Two tasks were simulated: an alternating F/E task and a slow F/E tracking task. Emergence of γ-motor activity in the alternating F/E network was a function of α-motor unit drive: if muscle afferent (together with supraspinal) input was required for driving α-motor units, then γ-drive emerged in the form of α-γ coactivation, as predicted by empirical studies. In the slow F/E tracking network, γ-drive emerged in the form of α-γ dissociation and provided critical, bidirectional muscle afferent activity to the cortical network, containing known bidirectional target units. The model thus demonstrates the complementary aspects of spindle output and hence γ-drive: i) muscle spindle activity as a driving force of α-motor unit activity, and ii) afferent activity providing continuous sensory information, both of which crucially depend on γ-drive.

  6. Gender specific changes in cortical activation patterns during exposure to artificial gravity

    Science.gov (United States)

    Schneider, Stefan; Robinson, Ryan; Smith, Craig; von der Wiesche, Melanie; Goswami, Nandu

    2014-11-01

    Keeping astronauts healthy during long duration spaceflight remains a challenge. Artificial gravity (AG) generated by a short arm human centrifuges (SAHC) is proposed as the next generation of integrated countermeasure devices that will allow human beings to safely spend extended durations in space, although comparatively little is known about any psychological side effects of AG on brain function. 16 participants (8 male and 8 female, GENDER) were exposed to 10 min at a baseline gravitational load (G-Load) of +.03 Gz, then 10 min at +.6 Gz for females and +.8 Gz for males, before being exposed to increasing levels of AG in a stepped manner by increasing the acceleration by +.1 Gz every 3 min until showing signs of pre-syncope. EEG recordings were taken of brain activity during 2 min time periods at each AG level. Analysing the results of the mixed total population of participants by two way ANOVA, a significant effect of centrifugation on alpha and beta activity was found (p<.01). Furthermore results revealed a significant interaction between G-LOAD and GENDER alpha-activity (p<.01), but not for beta-activity. Although the increase in alpha and beta activity with G-LOAD does not reflect a general model of cortical arousal and therefore cannot support previous findings reporting that AG may be a cognitively arousing environment, the gender specific responses identified in this study may have wider implications for EEG and AG research.

  7. Inductive QSAR Descriptors. Distinguishing Compounds with Antibacterial Activity by Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Artem Cherkasov

    2005-01-01

    Full Text Available Abstract: On the basis of the previous models of inductive and steric effects, ‘inductive’ electronegativity and molecular capacitance, a range of new ‘inductive’ QSAR descriptors has been derived. These molecular parameters are easily accessible from electronegativities and covalent radii of the constituent atoms and interatomic distances and can reflect a variety of aspects of intra- and intermolecular interactions. Using 34 ‘inductive’ QSAR descriptors alone we have been able to achieve 93% correct separation of compounds with- and without antibacterial activity (in the set of 657. The elaborated QSAR model based on the Artificial Neural Networks approach has been extensively validated and has confidently assigned antibacterial character to a number of trial antibiotics from the literature.

  8. Health of children born through artificial oocyte activation: a pilot study.

    Science.gov (United States)

    Deemeh, Mohammad R; Tavalaee, Marziyeh; Nasr-Esfahani, Mohammad H

    2015-03-01

    Artificial oocyte activation (AOA) has shown to improve fertility in severe male infertility following intracytoplasmic sperm insemination (ICSI). However, the effect of AOA on the health status of children has not been studied. This pilot historical cohort study aims to evaluate physical and mental health of 79 and 89 children from 275 and 406 couples undergoing ICSI-AOA using ionomycin and conventional ICSI, respectively. The outcomes assessed were clinical pregnancy, abortion, type of delivery, and health of children (major birth defect, mental and behavior status). No significant differences were observed between the ICSI-AOA and the ICSI groups for these parameters, and the rate of major birth defects were not significantly different between the 2 groups. In this study, AOA has not imposed a greater risk on physical and mental health of children born through AOA, but for such a solid conclusion, further trails with higher number of cases are required and conclusions drawn are limited to this study.

  9. Indications for influence of artificial (man-made) activity on radon signals, in simulation experiments

    Science.gov (United States)

    Steinitz, G.; Kotlarsky, P.; Piatibratova, O.

    2016-11-01

    Radon (Rn-222; a radioactive noble gas) is characterized by large temporal variations that differ significantly from variations of (i) other trace elements in geogas (noble gases); (ii) variation patterns of other dynamic geophysical systems (atmospheric, tidal). Consensus exists that there is no simple and straightforward understanding of the phenomena and its behaviour. This lacuna in the understanding of the underlying principles hampers the development of applications-such as radon as a proxy of processes in the seismogenic context. Using results from field investigations and simulation experiments the GSI suggested that an unidentified extraterrestrial component, probably in solar radiation, drives periodic radon signals in the diurnal and annual frequency bands. Recent findings from experimental investigations shed additional perspectives allowing a new evaluation of the issue. Particular transient signals, measured with alpha and gamma detectors, are interpreted to reflect the influence of artificial activity. Criteria are (i) signals lasting several hours that occur around midday on workdays (Sunday-Thursday); (ii) signals composed of a train of around 10 strong pulses, each lasting less than 15 min, occurring within several hours once a week, from Wednesday afternoon/evening to Thursday morning. A first interpretation is that an unidentified artificial activity of some sort (industrial?) generates and emits an unidentified agent that reaches enhanced confined mode experiments at the GSI laboratory, which respond to the incoming agent in the form of radon signals. Developing the capability of identification of such an earth-bound source generating an influencing agent is a key step towards understanding of external influence on radioactivity of radon.

  10. Magnetorotational instability in protoplanetary discs

    CERN Document Server

    Salmeron, Roberto Aureliano; Salmeron, Raquel; Wardle, Mark

    2004-01-01

    We investigate the linear growth and vertical structure of the magnetorotational instability (MRI) in weakly ionised, stratified accretion discs. The magnetic field is initially vertical and dust grains are assumed to have settled towards the midplane, so charges are carried by electrons and ions only. Solutions are obtained at representative radial locations from the central protostar for different choices of the initial magnetic field strength, sources of ionisation, and disc surface density. The MRI is active over a wide range of magnetic field strengths and fluid conditions in low conductivity discs. For the minimum-mass solar nebula model, incorporating cosmic ray ionisation, perturbations grow at 1 AU for B < 8 G. For a significant subset of these strengths (0.2 - 5 G), the growth rate is of order the ideal MHD rate (0.75 Omega). Similarly, when cosmic rays are assumed to be excluded from the disc by the winds emitted by the magnetically active protostar, unstable modes grow at this radius for B less...

  11. Black hole accretion discs

    CERN Document Server

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. outbursting black-hole low-mass X-ray binaries. We then turn to the role of advection in accretion flow onto black holes illustrating its action and importance with a toy model describing both ADAFs and slim discs. We conclude with a presentation of the general-relativistic formalism describing accretion discs in the Kerr space-time.

  12. MHD disc winds

    CERN Document Server

    Ferreira, J

    2006-01-01

    This is a doctorate level lecture on the physics of accretion discs driving magnetically self-confined jets, usually referred to in the literature as disc winds. I will first review the governing magnetohydrodynamic equations and then discuss their physical content. At that level, necessary conditions to drive jets from keplerian accretion discs can already be derived. These conditions are validated with self-similar calculations of accretion-ejection structures. In a second part, I will critically discuss the biases introduced when using self-similarity as well as some other questions such as: Are these systems really unstable? Can a standard accretion disc provide the conditions to launch jets in its innermost parts? What is the difference between X-winds and disc-winds? Finally, the magnetic interaction between a protostar and its circumstellar disc will be discussed with a focus on stellar spin down.

  13. Stimulation of whistler activity by an artificial ground-based low frequency acoustic wave source

    Science.gov (United States)

    Soroka, Silvestr; Kim, Vitaly; Khegay, Valery; Kalita, Bogdan

    This paper presents some results of an active experiment aimed to impact the ionosphere with low frequency acoustic waves artificially generated in the near-ground atmosphere. The main goal of the experiment was checking if the artificially generated acoustic waves could affect whistler occurrence at middle latitudes. As a source of acoustic waves we used twin powerful sonic speakers. One of which produced acoustic waves at a frequency of 600 Hz while the other one at a frequency of 624 Hz with intensity of 160 dB at a distance of 1 m away from end of the horn. The duration of sonic pulse was one minute. As a result of acoustic wave interference above the acoustic wave source there appears some kind of a virtual sonic antenna that radiates lower frequency acoustic waves at a frequency being equal to the difference of the two initially generated frequencies (624 Hz - 600 Hz = 24 Hz). The resulting acoustic wave is capable to penetrate to higher altitudes than the initially generated waves do because of its lower frequency. A whistler detector was located at about 100 m far away from the acoustic wave source. We performed the 50 experiments at Lviv (49.50° N, 24.00° E) with acoustic influence on the atmosphere-ionosphere system. The obtained results indicate that the emitted low frequency acoustic waves were clearly followed by enhanced whistler occurrence. We suggest that the observations could be interpreted how increase of transparency of ionosphere and upward refraction of VLF spherics resulted from modulation of local atmospheric parameters by the acoustic waves. These two effects produce to the increase of amount of the whistlers.

  14. Artificial neural network optimization of Althaea rosea seeds polysaccharides and its antioxidant activity.

    Science.gov (United States)

    Liu, Feng; Liu, Wenhui; Tian, Shuge

    2014-09-01

    A combination of an orthogonal L16(4)4 test design and a three-layer artificial neural network (ANN) model was applied to optimize polysaccharides from Althaea rosea seeds extracted by hot water method. The highest optimal experimental yield of A. rosea seed polysaccharides (ARSPs) of 59.85 mg/g was obtained using three extraction numbers, 113 min extraction time, 60.0% ethanol concentration, and 1:41 solid-liquid ratio. Under these optimized conditions, the ARSP experimental yield was very close to the predicted yield of 60.07 mg/g and was higher than the orthogonal test results (40.86 mg/g). Structural characterizations were conducted using physicochemical property and FTIR analysis. In addition, the study of ARSP antioxidant activity demonstrated that polysaccharides exhibited high superoxide dismutase activity, strong reducing power, and positive scavenging activity on superoxide anion, hydroxyl radical, 2,2-diphenyl-1-picrylhydrazyl, and reducing power. Our results indicated that ANNs were efficient quantitative tools for predicting the total ARSP content.

  15. Black hole accretion discs

    OpenAIRE

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. ou...

  16. An artificial HSE promoter for efficient and selective detection of heat shock pathway activity.

    Science.gov (United States)

    Ortner, Viktoria; Ludwig, Alfred; Riegel, Elisabeth; Dunzinger, Sarah; Czerny, Thomas

    2015-03-01

    Detection of cellular stress is of major importance for the survival of cells. During evolution, a network of stress pathways developed, with the heat shock (HS) response playing a major role. The key transcription factor mediating HS signalling activity in mammalian cells is the HS factor HSF1. When activated it binds to the heat shock elements (HSE) in the promoters of target genes like heat shock protein (HSP) genes. They are induced by HSF1 but in addition they integrate multiple signals from different stress pathways. Here, we developed an artificial promoter consisting only of HSEs and therefore selectively reacting to HSF-mediated pathway activation. The promoter is highly inducible but has an extreme low basal level. Direct comparison with the HSPA1A promoter activity indicates that heat-dependent expression can be fully recapitulated by isolated HSEs in human cells. Using this sensitive reporter, we measured the HS response for different temperatures and exposure times. In particular, long heat induction times of 1 or 2 h were compared with short heat durations down to 1 min, conditions typical for burn injuries. We found similar responses to both long and short heat durations but at completely different temperatures. Exposure times of 2 h result in pathway activation at 41 to 44 °C, whereas heat pulses of 1 min lead to a maximum HS response between 47 and 50 °C. The results suggest that the HS response is initiated by a combination of temperature and exposure time but not by a certain threshold temperature.

  17. Prominent artificial radionuclide activity in the environment of coastal Karnataka on the southwest coast of India

    Energy Technology Data Exchange (ETDEWEB)

    Narayana, Y. [Department of Studies in Physics, Mangalore University, Mangalagangotri-574 199 (India)]. E-mail: narayanay@yahoo.com; Somashekarappa, H.M.; Karunakara, N.; Avadhani, D.N.; Mahesh, H.M.; Siddappa, K. [Department of Studies in Physics, Mangalore University, Mangalagangotri-574 199 (India)

    2000-09-01

    Studies on radiation level and radionuclide distribution in the environment of coastal Karnataka were undertaken to provide baseline data for the future assessment of the impact of the nuclear and thermal power stations that are being set up in the region and to understand the behaviour of radionuclides in the environment. As part of the programme the concentrations of two important artificial radionuclides, namely {sup 90}Sr and {sup 137}Cs, have been measured in a number of environmental samples. The concentration of {sup 90}Sr is very low in most of the samples. Among the samples analysed for the concentration of {sup 137}Cs, soil samples showed elevated levels of activity in some sampling stations. Among the vegetables, brinjal (Solanum melongena. L) showed considerable activity. The internal dose due to intake of {sup 90}Sr through diet was 0.42 {mu}Sv year{sup -1} for the vegetarian population and 0.32 {mu}Sv year{sup -1} for the non-vegetarian population. The internal dose due to dietary intake of {sup 137}Cs was found to be 0.34 {mu}Sv year{sup -1} and 0.26 {mu}Sv year{sup -1} respectively for the vegetarian and non-vegetarian population. The results are discussed in the light of the literature values reported for other environs of India and abroad and appropriate inferences are drawn. (author)

  18. QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg-Marquardt algorithm.

    Science.gov (United States)

    Jalali-Heravi, M; Asadollahi-Baboli, M; Shahbazikhah, P

    2008-03-01

    A linear and non-linear quantitative structure-activity relationship (QSAR) study is presented for modeling and predicting heparanase inhibitors' activity. A data set that consisted of 92 derivatives of 2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid, furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acids is used in this study. Among a large number of descriptors, four parameters classified as physico-chemical, topological and electronic indices are chosen using stepwise multiple regression technique. The artificial neural networks (ANNs) model shows superiority over the multiple linear regressions (MLR) by accounting 87.9% of the variances of antiviral potency of the heparanase inhibitors. This paper focuses on investigating the role of weight update functions in developing ANNs. Levenberg-Marquardt (L-M) algorithm shows a better performance compared with basic back propagation (BBP) and conjugate gradient (CG) algorithms. The accuracy of 4-3-1 L-M ANN model was illustrated using leave-one-out (LOO), leave-multiple-out (LMO) cross-validations and Y-randomization. The mean effect of descriptors and sensitivity analysis show that log P is the most important parameter affecting the inhibitory behavior of the molecules.

  19. Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

    Science.gov (United States)

    Obexer, Richard; Godina, Alexei; Garrabou, Xavier; Mittl, Peer R. E.; Baker, David; Griffiths, Andrew D.; Hilvert, Donald

    2017-01-01

    Designing catalysts that achieve the rates and selectivities of natural enzymes is a long-standing goal in protein chemistry. Here, we show that an ultrahigh-throughput droplet-based microfluidic screening platform can be used to improve a previously optimized artificial aldolase by an additional factor of 30 to give a >109 rate enhancement that rivals the efficiency of class I aldolases. The resulting enzyme catalyses a reversible aldol reaction with high stereoselectivity and tolerates a broad range of substrates. Biochemical and structural studies show that catalysis depends on a Lys-Tyr-Asn-Tyr tetrad that emerged adjacent to a computationally designed hydrophobic pocket during directed evolution. This constellation of residues is poised to activate the substrate by Schiff base formation, promote mechanistically important proton transfers and stabilize multiple transition states along a complex reaction coordinate. The emergence of such a sophisticated catalytic centre shows that there is nothing magical about the catalytic activities or mechanisms of naturally occurring enzymes, or the evolutionary process that gave rise to them.

  20. Photodynamic activity of the boronated chlorin e6 amide in artificial and cellular membranes.

    Science.gov (United States)

    Antonenko, Yuri N; Kotova, Elena A; Omarova, Elena O; Rokitskaya, Tatyana I; Ol'shevskaya, Valentina A; Kalinin, Valery N; Nikitina, Roza G; Osipchuk, Julia S; Kaplan, Mikhail A; Ramonova, Alla A; Moisenovich, Mikhail M; Agapov, Igor I; Kirpichnikov, Mikhail P

    2014-03-01

    Photodynamic tumor-destroying activity of the boronated chlorin e6 derivative BACE (chlorin e6 13(1)-N-{2-[N-(1-carba-closo-dodecaboran-1-yl)methyl]aminoethyl}amide-15(2), 17(3)-dimethyl ester), previously described in Moisenovich et al. (2010) PLoS ONE 5(9) e12717, was shown here to be enormously higher than that of unsubstituted chlorin e6, being supported by the data on much higher photocytotoxicity of BACE in M-1 sarcoma cell culture. To validate membrane damaging effect as the basis of the enhanced tumoricidal activity, BACE was compared with unsubstituted chlorin e6 in the potency to photosensitize dye leakage from liposomes, transbilayer lipid flip-flop, inactivation of gramicidin A ionic channels in planar lipid membranes and erythrocyte hemolysis. In all the models comprising artificial and cellular membranes, the photodynamic effect of BACE exceeded that of chlorin e6. BACE substantially differed from chlorin e6 in the affinity to liposomes and erythrocytes, as monitored by fluorescence spectroscopy, flow cytometry and centrifugation. The results support the key role of membrane binding in the photodynamic effect of the boronated chlorin e6 amide.

  1. Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation.

    Science.gov (United States)

    Desantis, Agata; Onori, Annalisa; Di Certo, Maria Grazia; Mattei, Elisabetta; Fanciulli, Maurizio; Passananti, Claudio; Corbi, Nicoletta

    2009-02-01

    Our aim is to upregulate the expression level of the dystrophin related gene utrophin in Duchenne muscular dystrophy, thus complementing the lack of dystrophin functions. To this end, we have engineered synthetic zinc finger based transcription factors. We have previously shown that the artificial three-zinc finger protein named Jazz fused with the Vp16 activation domain, is able to bind utrophin promoter A and to increase the endogenous level of utrophin in transgenic mice. Here, we report on an innovative artificial protein, named CJ7, that consists of Jazz DNA binding domain fused to a novel activation domain derived from the regulatory multivalent adaptor protein Che-1/AATF. This transcriptional activation domain is 100 amino acids in size and it is very powerful as compared to the Vp16 activation domain. We show that CJ7 protein efficiently promotes transcription and accumulation of the acetylated form of histone H3 on the genomic utrophin promoter locus.

  2. Mini tunneling machine with activated discs up to 2,500 mm in diameter; Konstruktion von Microtunnelingmaschinen mit aktivierten Disken mit Durchmessern bis zu 2500 mm

    Energy Technology Data Exchange (ETDEWEB)

    Kotwica, K.; Gospodarczyk, P. [TU Berg- und Huettenakademie, Krakau (Poland). Lehrstuhl fuer Bergbau-, Aufbereitungs- und Transportmaschinen

    2004-09-01

    The paper describes a new type of cutting head with activated cutter discs, which has been designed for tunnelling in hard rock. The prototype version of the cutting head was designed and developed in Poland at the Krakow Technical University for Mining and Metallurgy (Department of Mining, Mineral Preparation and Transport Machines) in collaboration with the Katowice-based company REMAG. Presents the results of field trials that were carried out at REMAG's test site and examines how the cutting head could be used on a modular mini tunnelling machine for hard rock conditions. The technical features, mode of operation and nominal specifications of the new design are presented by way of models and diagrams. (orig.)

  3. The effect of preoperative factors on the function of the cervical spine after cervical artificial disc replacement:a minimal 3 years follow-up%术前因素对人工颈椎间盘置换术中期疗效的影响

    Institute of Scientific and Technical Information of China (English)

    田伟; 韩骁; 刘波; 李勤; 胡临; 李志宇; 袁强; 何达

    2010-01-01

    目的 探讨术前因素对Bryan人工颈椎间盘置换术中期随访治疗效果的影响.方法 对2003年12月至2006年1月实施的Bryan人工颈椎间盘置换术患者的临床资料进行回顾性分析,共50例患者61个椎间盘,其中单节段颈椎人工椎间盘置换39例,双节段颈椎人工椎问盘置换11例.评估患者病程长短、置换椎间隙高度、置换节段活动度等术前因素对末次随访疗效的影响.结果 截至2009年1月,术后36个月以上的53例患者中50例获得随访.随访时间36.0~55.6个月,呈偏态分布,中位数为41.9个月.术前神经症状时间936个月的患者JOA改善率中位数与≤3个月患者相比,差异具有统计学意义(P0.87的患者相比,末次随访JOA评分改善率及置换节段活动度均较低,差异具有统计学意义(P<0.05).结论 对于颈椎病及颈椎问盘突出症患者,应在神经功能障碍出现后早期行手术治疗.拟手术节段退变严重的患者,是人工椎间盘置换手术的相对禁忌.%Objective To evaluate the effect of preopertative factors on the function of the cervical spine after Bryan artificial disc replacement. Methods Fifty patients who underwent cervical disc replacement from December 2003 to January 2006 were investigated. The preopertative factors such as long course of disease, lose of motion or disc height at the operation level were evaluated for their effects on the motion of the operated disc and clinical results at the time of final follow-up. There were 35 males and 15 females. Thirty-nine patients received one-level disc replacement, 11 patients received two-level disc replacement. The age of patients was from 25 to 73 years, average was 49 years. Results Until January 2009, 50 cases of all the 53 patient who got operation for more than 3 years were followed up. The follow up period was from 36. 0 to 55.6 months, which showed a skewed distribution, with a median of 41.9 months.The patients, who got neural syndrome

  4. Induction of genomic instability and activation of autophagy in artificial human aneuploid cells

    Energy Technology Data Exchange (ETDEWEB)

    Ariyoshi, Kentaro [Hirosaki University, Institute of Radiation Emergency Medicine, 66-1 Hon-cho, Hirosaki 036-8564 (Japan); Miura, Tomisato; Kasai, Kosuke; Fujishima, Yohei [Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki 036-8564 (Japan); Oshimura, Mitsuo [Chromosome Engineering Research Center (CERC), Tottori University, Nishicho 86, Yonago, Tottori 683-8503 (Japan); Yoshida, Mitsuaki A., E-mail: ariyoshi@hirosaki-u.ac.jp [Hirosaki University, Institute of Radiation Emergency Medicine, 66-1 Hon-cho, Hirosaki 036-8564 (Japan)

    2016-08-15

    Highlights: • Clones with artificial aneuploidy of chromosome 8 or chromosome 22 both show inhibited proliferation and genomic instability. • Increased autophagy was observed in the artificially aneuploid clones. • Inhibition of autophagy resulted in increased genomic instability and DNA damage. • Intracellular levels of reactive oxygen species were up-regulated in the artificially aneuploid clones. - Abstract: Chromosome missegregation can lead to a change in chromosome number known as aneuploidy. Although aneuploidy is a known hallmark of cancer cells, the various mechanisms by which altered gene and/or DNA copy number facilitate tumorigenesis remain unclear. To understand the effect of aneuploidy occurring in non-tumorigenic human breast epithelial cells, we generated clones harboring artificial aneuploidy using microcell-mediated chromosome transfer. Our results demonstrate that clones with artificial aneuploidy of chromosome 8 or chromosome 22 both show inhibited proliferation and genomic instability. Also, the increased autophagy was observed in the artificially aneuploidy clones, and inhibition of autophagy resulted in increased genomic instability and DNA damage. In addition, the intracellular levels of reactive oxygen species were up-regulated in the artificially aneuploid clones, and inhibition of autophagy further increased the production of reactive oxygen species. Together, these results suggest that even a single extraneous chromosome can induce genomic instability, and that autophagy triggered by aneuploidy-induced stress is a mechanism to protect cells bearing abnormal chromosome number.

  5. Comparison of microdilution and disc diffusion methods in assessing the in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil against vaginal Candida isolates.

    Science.gov (United States)

    Ergin, A; Arikan, S

    2002-10-01

    The in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil was evaluated against 99 vaginal Candida strains by the broth microdilution and disc diffusion methods. The microdilution method was performed in accordance with NCCLS-M27A guidelines. An investigational method was used for the disc diffusion test. Fluconazole and tea tree oil minimum inhibitory concentrations (MICs) obtained at 48 h tended to increase 1- to 2-fold or remain the same compared to 24 h readings for most of the isolates tested. C. krusei and C. norvegensis had significantly higher MICs and smaller inhibition zones for fluconazole compared to other species. Tea tree oil MICs were found to be similar, in general, for all Candida spp. tested. The geometric mean MIC of tea tree oil for all isolates was 2.2% (range, 0.25-4%) at 24 h and 3.0% (range, 1-8%) at 48 h. Tea tree oil mean inhibition zone diameter was 24 mm (range, 14-42 mm) at 24 h and 15.8 mm (range, 10-35 mm) at 48 h. In vitro activity of tea tree oil against fluconazole-resistant Candida strains was of particular interest. The isolates had similar tea tree oil MICs and inhibition zone diameters regardless of their fluconazole susceptibility profile. Tea tree oil MIC ranges (inhibition zone diameter ranges) were 2-4% (12-21 mm) and 2% (35 mm) at 48 h for C. krusei and C. norvegensis, respectively. These results suggest that tea tree oil MICs of the fluconazole-resistant isolates are comparable to those of fluconazole-susceptible isolates. This in vitro finding is promising for potential use of topical tea tree oil formulations in the treatment of candidiasis due to fluconazole-resistant strains.

  6. Seasonal prediction of tropical cyclone activity over the north Indian Ocean using three artificial neural networks

    Science.gov (United States)

    Nath, Sankar; Kotal, S. D.; Kundu, P. K.

    2016-12-01

    Three artificial neural network (ANN) methods, namely, multilayer perceptron (MLP), radial basis function (RBF) and generalized regression neural network (GRNN) are utilized to predict the seasonal tropical cyclone (TC) activity over the north Indian Ocean (NIO) during the post-monsoon season (October, November, December). The frequency of TC and large-scale climate variables derived from NCEP/NCAR reanalysis dataset of resolution 2.5° × 2.5° were analyzed for the period 1971-2013. Data for the years 1971-2002 were used for the development of the models, which were tested with independent sample data for the year 2003-2013. Using the correlation analysis, the five large-scale climate variables, namely, geopotential height at 500 hPa, relative humidity at 500 hPa, sea-level pressure, zonal wind at 700 hPa and 200 hPa for the preceding month September, are selected as potential predictors of the post-monsoon season TC activity. The result reveals that all the three different ANN methods are able to provide satisfactory forecast in terms of the various metrics, such as root mean-square error (RMSE), standard deviation (SD), correlation coefficient ( r), and bias and index of agreement ( d). Additionally, leave-one-out cross validation (LOOCV) method is also performed and the forecast skill is evaluated. The results show that the MLP model is found to be superior to the other two models (RBF, GRNN). The (MLP) is expected to be very useful to operational forecasters for prediction of TC activity.

  7. Follow-up Study on the Motion Range after Treatment of Degenerative Disc Disease with the Bryan Cervical Disc Prosthesis

    Institute of Scientific and Technical Information of China (English)

    YANG Shuhua; HU Yong; ZHAO Jijun; HE Xianfeng; LIU Yong; XU Weihua; DU Jingyuan; FU Dehao

    2007-01-01

    This study examined effect of a new intervertebral cervical disc prosthesis in relieving the neurological symptoms and signs, improving the patients' ability to perform daily activities, reducing pain, and maintaining the stability and segmental motion. From December 2003 to October 2004, 12 patients, who had received 14 replacements of cervical artificial discs, were followed-up for 2 to 8 months (with a mean of 5.2 months). Of them 5 had cervical spondylotic myelopathy and 7 had cervical disc herniation. The patients included 7 males and 5 females, with their age ranging from 35 to 62 y and a mean of 50.3 y. Single-level replacements were performed in 10 cases and 2 cases received two-level replacement. Operation time of the single-level surgery averaged 130±50 min and the time of two-level surgery was 165±53 min on average (from skin incision to skin suturing).Neurological or vascular complications during or after surgery was not observed. Japanese Orthopedic Association scores (JOA scores) increased from 8.6 to 15.8 on average. There was no prothesis subsidence or excursion. Replaced segments were stable and the range of motion was partially restored, being 4.68° (3.6°-6.1°) in flexion and extension position and 3.51° (2.5°-4.6°) 3.42° (2.6°-4.3°) in left and right bending position. No obvious loss of physiological curvature was noted. CT or MRI follow-up showed that excursion was less than 1.5 mm) in 2 of 14 levels and between 1.5 mm and 3 mm) in 1 of 14 levels. No ossification in the replaced levels was observed. It is concluded that satisfactory short-term results were achieved in the 12 cases of artificial disc replacements. Different from anterior cervical discectomy and fusion, the replacement could achieve quick functional recovery and did not lead to the movement limitation of cervical vertebrae. At least a 5-years follow-up was needed to assess the long-term effect of the prosthesis on its neighboring segments.

  8. Dynamic, six-axis stiffness matrix characteristics of the intact intervertebral disc and a disc replacement.

    Science.gov (United States)

    Holsgrove, Timothy P; Gill, Harinderjit S; Miles, Anthony W; Gheduzzi, Sabina

    2015-11-01

    Thorough pre-testing is critical in assessing the likely in vivo performance of spinal devices prior to clinical use. However, there is a lack of data available concerning the dynamic testing of lumbar (porcine model) total disc replacements in all six axes under preload conditions. The aim of this study was to provide new data comparing porcine lumbar spinal specimen stiffness between the intact state and after the implantation of an unconstrained total disc replacement, in 6 degrees of freedom. The dynamic, stiffness matrix testing of six porcine lumbar isolated disc specimens was completed using triangle waves at a test frequency of 0.1 Hz. An axial preload of 500 N was applied during all testing. Specimens were tested both in the intact condition and after the implantation of the total disc replacement. Sixteen key stiffness terms were identified for the comparison of the intact and total disc replacement specimens, comprising the 6 principal stiffness terms and 10 key off-axis stiffness terms. The total disc replacement specimens were significantly different to the intact specimens in 12 of these key terms including all six principal stiffness terms. The implantation of the total disc replacement resulted in a mean reduction in the principal stiffness terms of 100%, 91%, and 98% in lateral bending, flexion-extension, and axial rotation, respectively. The novel findings of this study have demonstrated that the unconstrained, low-friction total disc replacement does not replicate the stiffness of the intact specimens. It is likely that other low-friction total disc replacements would produce similar results due to stiffness being actively minimised as part of the design of low-friction devices, without the introduction of stiffening elements or mechanisms to more accurately replicate the mechanical properties of the natural intervertebral disc. This study has demonstrated, for the first time, a method for the quantitative comparative mechanical function

  9. Active Noise Control Using a Functional Link Artificial Neural Network with the Simultaneous Perturbation Learning Rule

    Directory of Open Access Journals (Sweden)

    Ya-li Zhou

    2009-01-01

    Full Text Available In practical active noise control (ANC systems, the primary path and the secondary path may be nonlinear and time-varying. It has been reported that the linear techniques used to control such ANC systems exhibit degradation in performance. In addition, the actuators of an ANC system very often have nonminimum-phase response. A linear controller under such situations yields poor performance. A novel functional link artificial neural network (FLANN-based simultaneous perturbation stochastic approximation (SPSA algorithm, which functions as a nonlinear mode-free (MF controller, is proposed in this paper. Computer simulations have been carried out to demonstrate that the proposed algorithm outperforms the standard filtered-x least mean square (FXLMS algorithm, and performs better than the recently proposed filtered-s least mean square (FSLMS algorithm when the secondary path is time-varying. This observation implies that the SPSA-based MF controller can eliminate the need of the modeling of the secondary path for the ANC system.

  10. Active galactic nuclei synapses: X-ray versus optical classifications using artificial neural networks

    CERN Document Server

    Gonzalez-Martin, O; Acosta-Pulido, J A; Masegosa, J; Papadakis, I E; Rodriguez-Espinosa, J M; Marquez, I; Hernandez-Garcia, L

    2014-01-01

    (Abridged) Many classes of active galactic nuclei (AGN) have been defined entirely throughout optical wavelengths while the X-ray spectra have been very useful to investigate their inner regions. However, optical and X-ray results show many discrepancies that have not been fully understood yet. The aim of this paper is to study the "synapses" between the X-ray and optical classifications. For the first time, the new EFLUXER task allowed us to analyse broad band X-ray spectra of emission line nuclei (ELN) without any prior spectral fitting using artificial neural networks (ANNs). Our sample comprises 162 XMM-Newton/pn spectra of 90 local ELN in the Palomar sample. It includes starbursts (SB), transition objects (T2), LINERs (L1.8 and L2), and Seyferts (S1, S1.8, and S2). The ANNs are 90% efficient at classifying the trained classes S1, S1.8, and SB. The S1 and S1.8 classes show a wide range of S1- and S1.8-like components. We suggest that this is related to a large degree of obscuration at X-rays. The S1, S1.8...

  11. Compact molecular disc and ionized gas outflows within 350 pc of the active nucleus of Mrk 1066

    CERN Document Server

    Riffel, Rogemar A

    2010-01-01

    We present stellar and gaseous kinematics of the inner 350 pc radius of the Seyfert galaxy Mrk1066 derived from J and Kl bands data obtained with the Gemini NIFS at a spatial resolution of 35 pc. The stellar velocity field is dominated by rotation in the galaxy plane but shows an S-shape distortion along the galaxy minor axis which seems to be due to an oval structure seen in an optical continuum image. Along this oval, between 170 and 280 pc from the nucleus we find a partial ring of low sigma (~50 km/s) attributed to an intermediate age stellar population. Fro measurements of the emission-line fluxes and profiles ([PII]1.19um, [FeII]1.26um, Pa-beta and H2 2.12um), we have constructed maps for the gas centroid velocity, velocity dispersion, as well as channel maps. The velocity fields for all emission lines are dominated by a similar rotation pattern to that observed for the stars, but are distorted by the presence of two structures: (i) a compact rotating disc with radius r~70 pc; (ii) outflows along the ra...

  12. Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes.

    Science.gov (United States)

    Roux, Yoann; Ricoux, Rémy; Avenier, Frédéric; Mahy, Jean-Pierre

    2015-09-30

    Development of artificial systems, capable of delivering electrons to metal-based catalysts for the reductive activation of dioxygen, has been proven very difficult for decades, constituting a major scientific lock for the elaboration of environmentally friendly oxidation processes. Here we demonstrate that the incorporation of a flavin mononucleotide (FMN) in a water-soluble polymer, bearing a locally hydrophobic microenvironment, allows the efficient reduction of the FMN by NADH. This supramolecular entity is then capable of catalysing a very fast single-electron reduction of manganese(III) porphyrin by splitting the electron pair issued from NADH. This is fully reminiscent of the activity of natural reductases such as the cytochrome P450 reductases with kinetic parameters, which are three orders of magnitude faster compared with other artificial systems. Finally, we show as a proof of concept that the reduced manganese porphyrin activates dioxygen and catalyses the oxidation of organic substrates in water.

  13. Live birth after artificial oocyte activation using a ready-to-use ionophore: a prospective multicentre study.

    Science.gov (United States)

    Ebner, Thomas; Montag, Markus; Montag, M; Van der Ven, K; Van der Ven, H; Ebner, T; Shebl, O; Oppelt, P; Hirchenhain, J; Krüssel, J; Maxrath, B; Gnoth, C; Friol, K; Tigges, J; Wünsch, E; Luckhaus, J; Beerkotte, A; Weiss, D; Grunwald, K; Struller, D; Etien, C

    2015-04-01

    Artificial oocyte activation has been proposed as a suitable means to overcome the problem of failed or impaired fertilization after intracytoplasmic sperm injection (ICSI). In a multicentre setting artificial oocyte activation was applied to 101 patients who were diagnosed with fertilization abnormalities (e.g. less than 50% fertilized oocytes) in a previous conventional ICSI cycle. Female gametes were activated for 15 min immediately after ICSI using a ready-to-use Ca(2+)-ionophore solution (A23187). Fertilization, pregnancy and live birth rates were compared with the preceding cycle without activation. The fertilization rate of 48% in the study cycles was significantly higher compared with the 25% in the control cycles (P splitting of the historical control group into failed (0%), low (1-30%) and moderate fertilization rate (31-50%) showed that all groups significantly benefitted (P embryo transfer cancelled compared with their previous treatments (1/101 versus 15/101). In total, 99% of the patients had an improved outcome with A23187 application resulting in a 28% live birth rate (35 babies). These data suggest that artificial oocyte activation using a ready-to-use compound is an efficient method.

  14. Spinning out of control: wall turbulence over rotating discs

    CERN Document Server

    Wise, Daniel J; Ricco, Pierre

    2014-01-01

    The friction drag reduction in a turbulent channel flow generated by surface-mounted rotating disc actuators is investigated numerically. The wall arrangement of the discs has a complex and unexpected effect on the flow. For low disc-tip velocities, the drag reduction scales linearly with the percentage of the actuated area, whereas for higher disc-tip velocity the drag reduction can be larger than the prediction found through the linear scaling with actuated area. For medium disc-tip velocities, all the cases which display this additional drag reduction exhibit stationary-wall regions between discs along the streamwise direction. This effect is caused by the viscous boundary layer which develops over the portions of stationary wall due to the radial flow produced by the discs. For the highest disc-tip velocity, the drag reduction even increases by halving the number of discs. The power spent to activate the discs is instead independent of the disc arrangement and scales linearly with the actuated area for al...

  15. Artificial cervical disc prosthesis and zero-profile interbody fixation and fusion system for cervical disease:2-year follow-up%人工颈椎间盘假体联合零切迹椎间融合内固定系统置入治疗颈椎病:2年随访

    Institute of Scientific and Technical Information of China (English)

    董振宇; 楚戈; 黄异飞; 袁凤云

    2015-01-01

    BACKGROUND:Artificial cervical disc prosthesis simulates range of motion and buffer shock function of normal intervertebral discs. Clinical experiments verify that artificial cervical disc prosthesis material has good biocompatibility and mechanical characteristics. OBJECTIVE:To evaluate artificial cervical disc replacement and zero-profile interbody fixation and fusion system for multilevel cervical disease in 2-year folow-up. METHODS:Artificial cervical disc replacement and zero-profile interbody fixation and fusion system were used to treat 42 patients with multilevel cervical disease. The patient presented typical symptoms and signs of spinal cord or nerve root compression. There were 18 cases of cervical myelopathy, 15 cases of nerve root cervical spondylosis and 10 cases of mixed type of cervical spondylosis. After treatment, mean operation time, blood loss and reoperation rate were measured. Postoperative complications, disability index of neck function, visual analog scale, function unit range of corresponding surgery segments of the cervical spine, Cobb angle of C2-C7 vertebral body, range of motion of adjacent segment of proximal and distal vertebral bodies were observed and clinical outcomes were evaluated. RESULTS AND CONCLUSION: Al cases finished the operation and were scored at various time points. After treatment, radiating pain of shoulder and neck and upper extremity were remarkably lessened. Numbness and sensory loss symptoms disappeared obviously. Quality of life elevated noticeably. Visual analog scale and the disability index of neck function score were decreased in final folow-up compared with pre-treatment (P < 0.001). C2-C7 vertebrae Cobb angle, FSU angle, range of motion of proximal surgery adjacent segment and range of motion of the distal surgery adjacent segment were elevated compared with pre-treatment (P < 0.001). These data indicate that cervical spondylosis was improved after treatment. Each index of cervical spondylosis after

  16. Short-and medium-term efficacy of artificial cervical disc replacement versus fusion for cervical spondylosis%人工颈椎间盘置换与融合治疗颈椎病:中短期疗效的比较

    Institute of Scientific and Technical Information of China (English)

    高明勇; 陶海鹰; 卫爱林; 贺斌

    2014-01-01

    BACKGROUND:Recently, non-fusion technology representing as artificial cervical disc replacement continues to improve. On the basis of reconstruction of disc structure and function of involved segments, cervical spine structure of surgery area segment is significantly close to dynamic and static load stress distribution required by natural physiological systems. It effects are apparent in protecting intervertebral facet joints of degenerated segment and structure and function of the cervical spine of adjacent segments and in maintaining cervical dynamic stability, which presented obvious methodological strengths compared with segmental fusion technology. OBJECTIVE:To evaluate the clinical outcomes of anterior cervical discectomy and fusion and Bryan artificial cervical disc replacement in the treatment of single-level cervical spondylotic myelopathy or radiculopathy. METHODS:A total of 43 middle and old age patients with single-level cervical spondylotic myelopathy or radiculopathy, who were treated from March 2010 to March 2012, were enrol ed in this study. They were randomly assigned to anterior cervical discectomy and fusion group (fusion group) and Bryan artificial cervical disc replacement group. Range-of-motion of cervical overal and adjacent intervertebral area near the intervertebral space was observed with radiography. During fol ow-up, postoperative recovery of neurological function was evaluated using Japanese Orthopaedic Association scale, visual analog scale and neck disability index. RESULTS AND CONCLUSION:None patients experienced complications of neurovascular injury during and after the surgery. Range-of-motion of postoperative overal cervical vertebra and adjacent joint was improved in the Bryan artificial cervical disc replacement group compared with the fusion group. Neurological function was apparently improved after surgery in each group. At 3 months after surgery, scores of Japanese Orthopaedic Association, visual analog scale and neck

  17. Kinetics of aerobically activated sludge on terylene artificial silk printing and dyeing wastewater treatment

    Institute of Scientific and Technical Information of China (English)

    官宝红; 吴忠标; 徐根良

    2004-01-01

    Aerobically activated sludge processing was carried out to treat terylene artificial silk printing and dyeing wastewater (TPD wastewater) in a lab-scale experiment, focusing on the kinetics of the COD removal.The kinetics parameters determined from experiment were applied to evaluate the biological treatability of wastewater.Experiments showed that COD removal could be divided into two stages,in which the ratio BOD/COD (B/C) was the key factor for stage division.At the rapid-removal stage with B/C>0.1,COD removal could be described by a zero order reaction. At the moderate-removal stage with B/C<0.1,COD removal could be described by a first order reaction. Then Monod equation was introduced to indicate COD removal. The reaction rate constant (K) and half saturation constant (Ks) were 0.0208-0.0642L/(gMLSS)h and 0.44-0.59(gCOD)/L respectively at 20℃-35℃.Activation energy (Ea) was 6.05×104 J/mol.By comparison of kinetic parameters, the biological treatability of TPD wastewater was superior to that of traditional textile wastewater.But COD removal from TPD-wastewater was much more difficult than that from domestic and industrial wastewater,such as papermaking, beer, phenol wastewater, etc.The expected effluent quality strongly related to un-biodegradable COD and kinetics rather than total COD. The results provide useful basis for further scaling up an defficient operation of TPD wastewater treatment.

  18. Kinetics of aerobically activated sludge on terylene artificial silk printing and dyeing wastewater treatment

    Institute of Scientific and Technical Information of China (English)

    官宝红; 吴忠标; 徐根良

    2004-01-01

    Aerobically activated sludge processing was carried out to treat terylene artificial silk printing and dyeing wastewater (TPD wastewater) in a lab-scale experiment, focusing on the kinetics of the COD removal. The kinetics parameters determined from experiment were applied to evaluate the biological treatability of wastewater. Experiments showed that COD removal could be divided into two stages, in which the ratio BOD/COD (B/C) was the key factor for stage division. At the rapid-removal stage with B/C>0.1, COD removal could be described by a zero order reaction. At the moderate-removal stage with B/C<0.1, COD removal could be described by a first order reaction. Then Monod equation was introduced to indicate COD removal. The reaction rate constant (K) and half saturation constant (KS) were 0.0208-0.0642 L/(gMLSS)·h and 0.44-0.59 (gCOD)/L respectively at 20 ℃-35 ℃. Activation energy (Ea) was 6.05×104 J/mol. By comparison of kinetic parameters, the biological treatability of TPD wastewater was superior to that of traditional textile wastewater. But COD removal from TPD-wastewater was much more difficult than that from domestic and industrial wastewater, such as papermaking, beer, phenol wastewater, etc. The expected effluent quality strongly related to un-biodegradable COD and kinetics rather than total COD. The results provide useful basis for further scaling up and efficient operation of TPD wastewater treatment.

  19. The case for cases B and C: intrinsic hydrogen line ratios of the broad-line region of active galactic nuclei, reddenings, and accretion disc sizes

    Science.gov (United States)

    Gaskell, C. Martin

    2017-01-01

    Low-redshift active galactic nuclei (AGNs) with extremely blue optical spectral indices are shown to have a mean, velocity-averaged, broad-line Hα/Hβ ratio of ≈2.72 ± 0.04, consistent with a Baker-Menzel Case B value. Comparison of a wide range of properties of the very bluest AGNs with those of a luminosity-matched subset of the Dong et al. blue AGN sample indicates that the only difference is the internal reddening. Ultraviolet fluxes are brighter for the bluest AGNs by an amount consistent with the flat AGN reddening curve of Gaskell et al. (2004). The lack of a significant difference in the GALEX (FUV-NUV) colour index strongly rules out a steep SMC-like reddening curve and also argues against an intrinsically harder spectrum for the bluest AGNs. For very blue AGNs the Lyα/Hβ ratio is also consistent with being the Case B value. The Case B ratios provide strong support for the self-shielded broad-line model of Gaskell, Klimek & Nazarova. It is proposed that the greatly enhanced Lyα/Hβ ratio at very high velocities is a consequence of continuum fluorescence in the Lyman lines (Case C). Reddenings of AGNs mean that the far-UV luminosity is often underestimated by up to an order of magnitude. This is a major factor causing the discrepancies between measured accretion disc sizes and the predictions of simple accretion disc theory. Dust covering fractions for most AGNs are lower than has been estimated. The total mass in lower mass supermassive black holes must be greater than hitherto estimated.

  20. Short-term follow-up for artificial cervical disc replacement: Changes of stability and range of motion in cervical vertebra%人工颈椎间盘假体置换短期随访:颈椎稳定性及其运动范围变化

    Institute of Scientific and Technical Information of China (English)

    汤雪明; 徐南伟; 周栋; 蒋巍; 李海波

    2012-01-01

    背景:椎间盘摘除减压后的节段融合会限制节段的生理运动,造成邻近节段应力加大而导致其退变加速.目的:观察人工颈椎间盘植入假体治疗颈椎病短期随访中的稳定性及置换节段和颈椎整个节段的运动范围变化.方法:于2010-06/2011-08在常州市第二人民医院骨科共施行PCM钴铬合金颈椎间盘假体置换11例12个节段,男7例,女4例;脊髓型颈椎病8例,外伤性颈椎间盘突出3例.结果与结论:患者随访时间为3~12个月.置换后1,3,6个月以及末次随访时置换节段过屈过伸活动度、左右侧屈活动度与术前接近.置换后1个月、末次随访时患者日本矫形外科协会评分明显升高,而Oswestry颈椎功能障碍指数明显降低(P 0.05),同时X射线未发现假体松动、下沉或异位骨化等不良反应.提示PCM人工颈椎间盘置换后短期颈椎稳定功能活动效果较好.%BACKGROUND: Segment fusion after the discectomy decompression of cervical disc limits the physical exercise of the segment,which causes the accelerated degeneration due to increased stress of adjacent segment.OBJECTIVE: To observe stability and range of motion (ROM) in the replacement segment and cervical segment duringshort-term follow-up using artificial cervical disc replacement for the treatment of cervical disc disease.METHODS: Totally 11 cases (12 segments) who treated with cobalt-chromium alloy PCM cervical disc replacement fromDepartment of Orthopedics, the Second People's Hospital of Changzhou from June 2010 to August 2011 PCM were selectedincluding seven males and four females. Among these cases, there were eight cases with cervical myelopathy, and three caseswith traumatic cervical disc herniation.RESULTS AND CONCLUSION: All cases were followed-up for 3 to 12 months. ROM over flexion and extension, and flexionROM on lateral left and right were similar to preoperation at 1, 3, 6 months and final follow-up after replacement. Japaneseorthopaedic

  1. CFD Analysis Of Straight Ventilated Disc Brake

    Directory of Open Access Journals (Sweden)

    Nikhil K

    2016-05-01

    Full Text Available Brakes are the key pieces of a vehicle that plays an active role in safety and performance of the system. The study of aerodynamic cooling of a disc brake in real working condition of vehicle is important in present situations. Brake discs get very hot quickly, so it should be dissipated properly through different modes of heat transfer. Contributions of these heat transfer modes are different in different type of problems. The cooling transfer rates are different in vane surface and frictional surface of a disc brake. Also the temperature varies in each small interval of braking time. So a transient problem simulation is important to study the cooling of a disc brake when a vehicle decelerates from a particular speed. ANSYS CFX tool is used for the simulation of this transient problem.

  2. Gibberellic Acid, Synthetic Auxins, and Ethylene Differentially Modulate α-l-Arabinofuranosidase Activities in Antisense 1-Aminocyclopropane-1-Carboxylic Acid Synthase Tomato Pericarp Discs1

    Science.gov (United States)

    Sozzi, Gabriel O.; Greve, L. Carl; Prody, Gerry A.; Labavitch, John M.

    2002-01-01

    α-l-Arabinofuranosidases (α-Afs) are plant enzymes capable of releasing terminal arabinofuranosyl residues from cell wall matrix polymers, as well as from different glycoconjugates. Three different α-Af isoforms were distinguished by size exclusion chromatography of protein extracts from control tomatoes (Lycopersicon esculentum) and an ethylene synthesis-suppressed (ESS) line expressing an antisense 1-aminocyclopropane-1-carboxylic synthase transgene. α-Af I and II are active throughout fruit ontogeny. α-Af I is the first Zn-dependent cell wall enzyme isolated from tomato pericarp tissues, thus suggesting the involvement of zinc in fruit cell wall metabolism. This isoform is inhibited by 1,10-phenanthroline, but remains stable in the presence of NaCl and sucrose. α-Af II activity accounts for over 80% of the total α-Af activity in 10-d-old fruit, but activity drops during ripening. In contrast, α-Af III is ethylene dependent and specifically active during ripening. α-Af I released monosaccharide arabinose from KOH-soluble polysaccharides from tomato cell walls, whereas α-Af II and III acted on Na2CO3-soluble pectins. Different α-Af isoform responses to gibberellic acid, synthetic auxins, and ethylene were followed by using a novel ESS mature-green tomato pericarp disc system. α-Af I and II activity increased when gibberellic acid or 2,4-dichlorophenoxyacetic acid was applied, whereas ethylene treatment enhanced only α-Af III activity. Results suggest that tomato α-Afs are encoded by a gene family under differential hormonal controls, and probably have different in vivo functions. The ESS pericarp explant system allows comprehensive studies involving effects of physiological levels of different growth regulators on gene expression and enzyme activity with negligible wound-induced ethylene production. PMID:12114586

  3. Robust Fault-Tolerant Control for Satellite Attitude Stabilization Based on Active Disturbance Rejection Approach with Artificial Bee Colony Algorithm

    OpenAIRE

    Fei Song; Shiyin Qin

    2014-01-01

    This paper proposed a robust fault-tolerant control algorithm for satellite stabilization based on active disturbance rejection approach with artificial bee colony algorithm. The actuating mechanism of attitude control system consists of three working reaction flywheels and one spare reaction flywheel. The speed measurement of reaction flywheel is adopted for fault detection. If any reaction flywheel fault is detected, the corresponding fault flywheel is isolated and the spare reaction flywhe...

  4. Artificial ribonucleases.

    Science.gov (United States)

    Morrow, J R

    1994-01-01

    Many inorganic and organic compounds promote the reactions catalyzed by RNase A. Both the transesterification step, where a 2',3'-cyclic phosphate is formed with concomitant cleavage of RNA, and the hydrolysis step, where the 2',3'-cyclic phosphate is converted to a phosphate monoester, may be mimicked with compounds that are readily synthesized in the laboratory. Electrophilic activation of the phosphate ester and charge neutralization are generally important means by which artificial RNases promote phosphate diester displacement reactions. Several artificial RNases operate by a bifunctional general acid/general base mechanism, as does RNase A. Provision of an intramolecular nucleophile appears to be an important pathway for metal complex promoted phosphate diester hydrolysis. In contrast to the successful design of compounds that promote the reactions catalyzed by RNase A, there are no artificial nucleases to date that will cleave the 3' P-O bond of RNA or hydrolyze an oligonucleotide of DNA. Artificial RNases based on both metal complexes and organic compounds have been described. Metal complexes may be particularly effective catalysts for both transesterification and hydrolysis reactions of phosphate diesters. Under physiological conditions (37 degrees C and neutral pH), several metal complexes catalyze the transesterification of RNA. Future work should involve the development of metal complexes which are inert to metal ion release but which maintain open coordination sites for catalytic activity. The design of compounds containing multiple amine or imidazole groups that may demonstrate bifunctional catalysis is a promising route to new artificial RNases. Further design of these compounds and careful placement of catalytic groups may yield new RNase mimics that operate under physiological conditions. The attachment of artificial RNases to recognition agents such as oligodeoxynucleotides to create new sequence-specific endoribonucleases is an exciting field of

  5. Morphology controlled bulk synthesis of disc-shaped WO3 powder and evaluation of its photocatalytic activity for the degradation of phenols.

    Science.gov (United States)

    Aslam, M; Ismail, Iqbal M I; Chandrasekaran, S; Hameed, A

    2014-07-15

    The surfactant assisted synthesis of disc-shaped WO3 powder and its photocatalytic performance in sunlight exposure is reported. UV-vis DRS, XRD and FESEM characterized the synthesized WO3. The synthesized powder exhibited a bandgap of ∼2.55eV with cubic lattice and high crystallinity. The photocatalytic activity of the synthesized WO3 was examined for the degradation of phenol, resorcinol, 2-chlorophenol and 2-nitrophenol in complete spectrum and visible segment of sunlight. The highly efficient degradation/mineralization of 2-chloro and 2-nitrophenol compared to that of phenol and resorcinol, under identical experimental conditions, suggested the regulatory role of substituents attached to the aromatic ring in degradation/mineralization process. The time-scale HPLC degradation profiles, identification of intermediates by GC-MS and removal of organic carbon during the course of reaction were utilized to approximate the possible route of degradation/mineralization of phenolic substrates. The measurement of the anions released during the photocatalytic process was used to identify the nature of the major oxidants (O2(•-), OH(•)) and the possible interaction sites. A significant decrease in the photocatalytic activity of synthesized WO3, ∼50%, was observed in visible portion of sunlight however, a sustained activity was observed in the repeated exposures.

  6. ANALYSIS OF MONOPOLE ANTENNA ON CIRCULAR DISC BY MODE MATCHING

    Institute of Scientific and Technical Information of China (English)

    Sun Baohua; Zhang Fushun; Liu Qizhong

    2001-01-01

    Mode matching is used for the analysis of monopole antenna on circular disc, which is achieved by developing a novel model consisting of two artificial ground planes above and bellow the monopole antenna. Using this model, the input impedance is computed and compared with measured data reported in literatures, and excellent agreement is observed.

  7. Comparative study of artificial cervical disc replacement verus anterior cervical discectomy and fusion in the treatment of cervical spondylotic myelopathy%人工颈椎间盘置换与颈前路减压融合术治疗脊髓型颈椎病的对照研究

    Institute of Scientific and Technical Information of China (English)

    马晓勇; 陈涛平; 郭志学

    2012-01-01

    目的 比较人工颈椎间盘置换术与颈前路减压融合术治疗脊髓型颈椎病的疗效,评价其优缺点.方法 65例脊髓型颈椎病患者按照手术方式分为人工颈椎间盘置换术组(33例,行Bryan假体置换术)和颈前路减压融合术组(32例,行颈前路减压融合术).观察两组患者住院时间、术后颈部外固定时间以及术后恢复工作时间;两组患者于术前、术后3、6、12个月行日本矫形外科协会(JOA)评分,并行X线检测颈椎活动度(ROM);评价临床疗效及术后并发症.结果 人工颈椎间盘置换术组患者住院时间、术后颈部外固定时间以及术后恢复工作时间均显著短于颈前路减压融合术组(P < 0.01).两组术后12个月JOA评分均较术前明显提高(P < 0.05),两组差异无统计学意义(P > 0.05).人工颈椎间盘置换术组术后12个月单节段及双节段置换ROM较术前无显著改变(P > 0.05),颈前路减压融合术组术后12个月ROM较术前减小(P < 0.05或P < 0.01),且显著小于人工颈椎间盘置换术组(P < 0.05或P < 0.01).两组患者满意率无差异(P > 0.05).两组术后均无严重并发症发生.结论 人工颈椎间盘置换术治疗脊髓型颈椎病患者术后恢复快,住院时间短,颈部外固定时间短,使患者保持正常的颈椎活动度,临床疗效好,值得临床推广使用.%Objective To compare the efficacy of artificial cervical disc replacement verus anterior cervical discectomy and fusion (ACDF) in the treatment of cervical spondylotic myelopathy (CSM), and evaluate their advantages and disadvantages. Methods A total of 65 patients with CSM were divided into artificial cervical disc replacement group (33 patients) and ACDF group (32 patients). The hospital stay, postoperative cervical fixation time and postoperative time returning to work of the two groups were observed; the Japanese Orthopaedic Association (JOA) score and range of motion by X-ray before surgery, 3

  8. Sweet taste receptor expression in ruminant intestine and its activation by artificial sweeteners to regulate glucose absorption.

    Science.gov (United States)

    Moran, A W; Al-Rammahi, M; Zhang, C; Bravo, D; Calsamiglia, S; Shirazi-Beechey, S P

    2014-01-01

    Absorption of glucose from the lumen of the intestine into enterocytes is accomplished by sodium-glucose co-transporter 1 (SGLT1). In the majority of mammalian species, expression (this includes activity) of SGLT1 is upregulated in response to increased dietary monosaccharides. This regulatory pathway is initiated by sensing of luminal sugar by the gut-expressed sweet taste receptor. The objectives of our studies were to determine (1) if the ruminant intestine expresses the sweet taste receptor, which consists of two subunits [taste 1 receptor 2 (T1R2) and 3 (T1R3)], and other key signaling molecules required for SGLT1 upregulation in nonruminant intestines, and (2) whether T1R2-T1R3 sensing of artificial sweeteners induces release of glucagon-like peptide-2 (GLP-2) and enhances SGLT1 expression. We found that the small intestine of sheep and cattle express T1R2, T1R3, G-protein gustducin, and GLP-2 in enteroendocrine L-cells. Maintaining 110-d-old ruminating calves for 60d on a diet containing a starter concentrate and the artificial sweetener Sucram (consisting of saccharin and neohesperidin dihydrochalcone; Pancosma SA, Geneva, Switzerland) enhances (1) Na(+)-dependent d-glucose uptake by over 3-fold, (2) villus height and crypt depth by 1.4- and 1.2-fold, and (3) maltase- and alkaline phosphatase-specific activity by 1.5-fold compared to calves maintained on the same diet without Sucram. No statistically significant differences were observed for rates of intestinal glucose uptake, villus height, crypt depth, or enzyme activities between 50-d-old milk-fed calves and calves maintained on the same diet containing Sucram. When adult cows were kept on a diet containing 80:20 ryegrass hay-to-concentrate supplemented with Sucram, more than a 7-fold increase in SGLT1 protein abundance was noted. Collectively, the data indicate that inclusion of this artificial sweetener enhances SGLT1 expression and mucosal growth in ruminant animals. Exposure of ruminant sheep

  9. Identical location transmission electron microscopy in combination with rotating disc electrode measurements. The activity of fuel cell catalysts and their degradation

    Energy Technology Data Exchange (ETDEWEB)

    Schloegl, Katrin G.

    2011-07-13

    As an alternative to conventional combustion engines, the Proton Exchange Membrane Fuel Cell (PEMFC) using hydrogen as a fuel is a promising concept owing to its potential independence from fossil fuels, high efficiency and zero emissions. Concerning its commercial viability, the fundamental problem of high system cost per power output and lifetime is closely related to finding more active and stable catalysts for the oxygen reduction reaction. In the presented work, several methods are combined to examine the parameters and processes responsible for both activity and degradation of platinum-based catalysts. Degradation mechanisms are scrutinized by means of electrochemical measurements with the rotating disc electrode in combination with a recently developed TEM technique, which allows for the comparison of identical locations before and after accelerated stress tests. (orig.) [German] Die mit Wasserstoff betriebene Proton Exchange Membrane Brennstoffzelle (PEMFC) stellt aufgrund ihrer potentiellen Unabhaengigkeit von fossilen Energietraegern, ihrem hohen Wirkungsgrad und fehlendem Schadstoffausstoss eine vielversprechende Alternative zum konventionellen Verbrennungsmotor dar. Das grundlegende Problem der zu hohen Systemkosten und zu geringen Lebensdauer fuer kommerzielle Anwendungen ist eng mit der Entwicklung aktiverer und stabiler Elektrokatalysatoren fuer die Sauerstoffreduktion verknuepft. In der vorliegenden Arbeit werden verschiedene Methoden kombiniert, um die Parameter und Prozesse zu untersuchen, welche fuer die Aktivitaet und Degradation platinbasierter Katalysatoren verantwortlich sind. Zur Aufklaerung vorliegender Degradationsmechanismen werden elektrochemische Messungen mit der rotierenden Scheibenelektrode in Kombination mit einer neu entwickelten TEM Methode eingesetzt, welche es ermoeglicht, identische Stellen vor und nach beschleunigten Degradationstests zu untersuchen.

  10. Succession of soil microbial communities and enzyme activities in artificial soils

    NARCIS (Netherlands)

    Ditterich, Franziska; Poll, Christian; Pronk, Geertje Johanna; Heister, Katja; Chandran, Abhirosh; Rennert, Thilo; Kögel-Knabner, Ingrid; Kandeler, Ellen

    2016-01-01

    Soil microorganisms are frequently attached to mineral surfaces or organo-mineral complexes, yet little is known about the microbial colonization of different soil minerals. The use of artificial soils that differ only in their mineral composition (illite, montmorillonite, ferrihydrite, boehmite) an

  11. 人工颈椎间盘置换联合颈前路融合术治疗多节段脊髓型颈椎病%Treatment on multilevel cervical spondylotic myelopathy by artificial cervical disc replace-ment combined with anterior cervical discectomy and fusion

    Institute of Scientific and Technical Information of China (English)

    游新茂; 叶秀益; 宋滇文; 贾连顺

    2014-01-01

    Objective To explore the clinical effects of artificial cervical disc replacement( ACDR) combined with anterior cervical discectomy fusion ( ACDF ) for the treatment of multi-segmental cervical spondylotic myelopathy ( CSM) . Methods 18 cases with multi-segmental CSM which were treated by ACDR combined with ACDF were re-viewed. The stability of artificial disc, internal fixation and bone fusion were evaluated by X-ray films before opera-tive, immediate postoperative and follow-up. The JOA scores was evaluated also at the same time. Results 18 pa-tients were followed up from 24 to 60 months ( averaged 36 ± 9. 6 months) . The range of motion of the replacement segment were 13. 8° ± 6. 5° at preoperative and 12. 5° ± 5. 3° at the final follow-up, and there was no significant difference between them(P>0. 05). The preoperative JOA scores was 9. 5 ± 1. 5, which was improved to 14. 2 ± 2. 2 in 4 months after operation; Preoperative neurological symptoms were obviously alleviated in most patients, and the improvement ratio of JOA was 62. 7% ± 11. 2%. The results were excellent in 9 patients, good in 5, fair in 2 and poor in 2. There were no patient with false of internal fixation, and the position of artificial disc was good. Conclu-sions ACDR combined with ACDF is a good procedure for multi-segmental cervical spondylotic myelopathy, it not only maintain the cervical spine alignment with saving more movement segments,but also reduce the incidence of ad-jacent segment degeneration.%目的:评价人工颈椎间盘置换联合颈前路融合术治疗多节段脊髓型颈椎病的临床效果。方法采用人工颈椎间盘置换联合颈前路融合治疗18例多节段脊髓型颈椎病患者。根据术前、术后、随访时的颈椎X线片观察人工椎间盘、内固定、植骨融合以及JOA评分改善情况。结果18例均获随访,时间24~60(36±9.6)个月。置换间隙平均活动度术前为13.8°±6.5°,末次随访时为12.5°±5.3

  12. Activation of JNK signaling links IgI mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs

    Institute of Scientific and Technical Information of China (English)

    Ming-wei Zhu; Tian-chi Xin; Shun-yan Weng; Yin Gao; Ying-jie Zhang; Qi Li; Ming-fa Li

    2010-01-01

    Dear Editor, Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, lossof-function mutations in the neoplastic tumor suppressor genes (nTSGs) lethal(2)giant larvae (lgl), discs large (dlg) or scribble (scrib) cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1].

  13. Artificial intelligence

    CERN Document Server

    Hunt, Earl B

    1975-01-01

    Artificial Intelligence provides information pertinent to the fundamental aspects of artificial intelligence. This book presents the basic mathematical and computational approaches to problems in the artificial intelligence field.Organized into four parts encompassing 16 chapters, this book begins with an overview of the various fields of artificial intelligence. This text then attempts to connect artificial intelligence problems to some of the notions of computability and abstract computing devices. Other chapters consider the general notion of computability, with focus on the interaction bet

  14. Crystallization of Self-Propelled Hard Discs

    Science.gov (United States)

    Briand, G.; Dauchot, O.

    2016-08-01

    We experimentally study the crystallization of a monolayer of vibrated discs with a built-in polar asymmetry, a model system of active liquids, and contrast it with that of vibrated isotropic discs. Increasing the packing fraction ϕ , the quasicontinuous crystallization reported for isotropic discs is replaced by a transition, or a crossover, towards a "self-melting" crystal. Starting from the liquid phase and increasing the packing fraction, clusters of dense hexagonal-ordered packed discs spontaneously form, melt, split, and merge, leading to a highly intermittent and heterogeneous dynamics. For a packing fraction larger than ϕ*, a few large clusters span the system size. The cluster size distribution is monotonically decreasing for ϕ ϕ*, and is a power law at the transition. The system is, however, never dynamically arrested. The clusters permanently melt from place to place, forming droplets of an active liquid which rapidly propagate across the system. This self-melting crystalline state subsists up to the highest possible packing fraction, questioning the stability of the crystal for active discs unless it is at ordered close packing.

  15. Inhibition of cystathionine β-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation

    Science.gov (United States)

    Yan, Jun; Hu, Shufen; Zou, Kang; Xu, Min; Wang, Qianliang; Miao, Xiuhua; Yu, Shan Ping; Xu, Guang-Yin

    2016-01-01

    The pathogenesis of pain in lumbar disc herniation (LDH) remains poorly understood. We have recently demonstrated that voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neurons were sensitized in a rat model of LDH. However, the detailed molecular mechanism for sensitization of VGSCs remains largely unknown. This study was designed to examine roles of the endogenous hydrogen sulfide synthesizing enzyme cystathionine β-synthetase (CBS) in sensitization of VGSCs in a previously validated rat model of LDH. Here we showed that inhibition of CBS activity by O-(Carboxymethyl) hydroxylamine hemihydrochloride (AOAA) significantly attenuated pain hypersensitivity in LDH rats. Administration of AOAA also reduced neuronal hyperexcitability, suppressed the sodium current density, and right-shifted the V1/2 of the inactivation curve, of hindpaw innervating DRG neurons, which is retrogradely labeled by DiI. In vitro incubation of AOAA did not alter the excitability of acutely isolated DRG neurons. Furthermore, CBS was colocalized with NaV1.7 and NaV1.8 in hindpaw-innervating DRG neurons. Treatment of AOAA markedly suppressed expression of NaV1.7 and NaV1.8 in DRGs of LDH rats. These data suggest that targeting the CBS-H2S signaling at the DRG level might represent a novel therapeutic strategy for chronic pain relief in patients with LDH. PMID:27905525

  16. Robust Fault-Tolerant Control for Satellite Attitude Stabilization Based on Active Disturbance Rejection Approach with Artificial Bee Colony Algorithm

    Directory of Open Access Journals (Sweden)

    Fei Song

    2014-01-01

    Full Text Available This paper proposed a robust fault-tolerant control algorithm for satellite stabilization based on active disturbance rejection approach with artificial bee colony algorithm. The actuating mechanism of attitude control system consists of three working reaction flywheels and one spare reaction flywheel. The speed measurement of reaction flywheel is adopted for fault detection. If any reaction flywheel fault is detected, the corresponding fault flywheel is isolated and the spare reaction flywheel is activated to counteract the fault effect and ensure that the satellite is working safely and reliably. The active disturbance rejection approach is employed to design the controller, which handles input information with tracking differentiator, estimates system uncertainties with extended state observer, and generates control variables by state feedback and compensation. The designed active disturbance rejection controller is robust to both internal dynamics and external disturbances. The bandwidth parameter of extended state observer is optimized by the artificial bee colony algorithm so as to improve the performance of attitude control system. A series of simulation experiment results demonstrate the performance superiorities of the proposed robust fault-tolerant control algorithm.

  17. Activity levels and expression of antioxidant enzymes in the ascorbate-glutathione cycle in artificially aged rice seed.

    Science.gov (United States)

    Yin, Guangkun; Xin, Xia; Song, Chao; Chen, Xiaoling; Zhang, Jinmei; Wu, Shuhua; Li, Ruifang; Liu, Xu; Lu, Xinxiong

    2014-07-01

    Reactive oxygen species are the main contributors to seed deterioration. In order to study scavenging systems for reactive oxygen species in aged seed, we performed analyses using western blotting, real-time quantitative reverse-transcription polymerase chain reaction, high-performance liquid chromatography, and antioxidant enzyme activity analyses in artificially aged rice seeds (Oryza sativa L. cv. wanhua no.11). Aging seeds by storing them at 50 °C for 1, 9, or 17 months increased the superoxide radical and hydrogen peroxide levels and reduced the germination percentage from 99% to 92%, 55%, and 2%, respectively. The activity levels of superoxide dismutase (SOD), glutathione reductase (GR), and dehydroascorbate reductase (DHAR) did not change in aged seeds. In contrast, the activity levels of catalase (CAT), ascorbate peroxidase (APX), and monodehydroascorbate reductase (MDHAR) were significantly decreased in aged seeds, as were the expression of catalase and cytosolic ascorbate peroxidase protein. Transcript accumulation analysis showed that specific expression patterns were complex for each of the antioxidant enzyme types in the rice embryos. Overall, the expression of most genes was down-regulated, along with their protein expression. In addition, the reduction in the amount of ascorbate and glutathione was associated with the reduction in scavenging enzymes activity in aged rice embryos. Our data suggest that the depression of the antioxidant system, especially the reduction in the expression of CAT1, APX1 and MDHAR1, may be responsible for the accumulation of reactive oxygen species in artificially aged seed embryos, leading to a loss of seed vigor.

  18. The growth of planets by pebble accretion in evolving protoplanetary discs

    CERN Document Server

    Bitsch, Bertram; Johansen, Anders

    2015-01-01

    The formation of planets depends on the underlying protoplanetary disc structure, which influences both the accretion and migration rates of embedded planets. The disc itself evolves on time-scales of several Myr during which both temperature and density profiles change as matter accretes onto the central star. Here we use a detailed model of an evolving disc to determine the growth of planets by pebble accretion and their migration through the disc. Cores that reach their pebble isolation mass accrete gas to finally form giant planets with extensive gas envelopes, while planets that do not reach pebble isolation mass are stranded as ice giants and ice planets containing only minor amounts of gas in their envelopes. Unlike earlier population synthesis models, our model works without any artificial reductions in migration speed and for protoplanetary discs with gas and dust column densities similar to those inferred from observations. We find that in our nominal disc model the emergence of planetary embryos pr...

  19. Innervation of ''painful'' lumbar discs

    NARCIS (Netherlands)

    Coppes, MH; Marani, E; Thomeer, RTWM; Groen, GJ

    1997-01-01

    Study Design. The authors investigated the innervation of discographically confirmed degenerated and ''painful'' human intervertebral discs. Objective. To determine the type and distribution patterns of nerve fibers present in degenerated human intervertebral discs. Summary of Background Data. The i

  20. How do accretion discs break?

    Science.gov (United States)

    Dogan, Suzan

    2016-07-01

    Accretion discs are common in binary systems, and they are often found to be misaligned with respect to the binary orbit. The gravitational torque from a companion induces nodal precession in misaligned disc orbits. In this study, we first calculate whether this precession is strong enough to overcome the internal disc torques communicating angular momentum. We compare the disc precession torque with the disc viscous torque to determine whether the disc should warp or break. For typical parameters precession wins: the disc breaks into distinct planes that precess effectively independently. To check our analytical findings, we perform 3D hydrodynamical numerical simulations using the PHANTOM smoothed particle hydrodynamics code, and confirm that disc breaking is widespread and enhances accretion on to the central object. For some inclinations, the disc goes through strong Kozai cycles. Disc breaking promotes markedly enhanced and variable accretion and potentially produces high-energy particles or radiation through shocks. This would have significant implications for all binary systems: e.g. accretion outbursts in X-ray binaries and fuelling supermassive black hole (SMBH) binaries. The behaviour we have discussed in this work is relevant to a variety of astrophysical systems, for example X-ray binaries, where the disc plane may be tilted by radiation warping, SMBH binaries, where accretion of misaligned gas can create effectively random inclinations and protostellar binaries, where a disc may be misaligned by a variety of effects such as binary capture/exchange, accretion after binary formation.

  1. Artificial Intelligence.

    Science.gov (United States)

    Waltz, David L.

    1982-01-01

    Describes kinds of results achieved by computer programs in artificial intelligence. Topics discussed include heuristic searches, artificial intelligence/psychology, planning program, backward chaining, learning (focusing on Winograd's blocks to explore learning strategies), concept learning, constraint propagation, language understanding…

  2. Optic disc drusen

    DEFF Research Database (Denmark)

    Fledelius, Hans C

    2017-01-01

    , which, in view of the small disc at risk, may seem a paradox. METHODS: This is an observational retrospective study on an eye clinic series (n = 49), focusing on visual acuity, kinetic/static perimetry, and longitudinal trends, to include the question of eventual visual incapacity. RESULTS: Forty...

  3. Segmental mobility, disc height and patient-reported outcomes after surgery for degenerative disc disease: a prospective randomised trial comparing disc replacement and multidisciplinary rehabilitation.

    Science.gov (United States)

    Johnsen, L G; Brinckmann, P; Hellum, C; Rossvoll, I; Leivseth, G

    2013-01-01

    This prospective multicentre study was undertaken to determine segmental movement, disc height and sagittal alignment after total disc replacement (TDR) in the lumbosacral spine and to assess the correlation of biomechanical properties to clinical outcomes.A total of 173 patients with degenerative disc disease and low back pain for more than one year were randomised to receive either TDR or multidisciplinary rehabilitation (MDR). Segmental movement in the sagittal plane and disc height were measured using distortion compensated roentgen analysis (DCRA) comparing radiographs in active flexion and extension. Correlation analysis between the range of movement or disc height and patient-reported outcomes was performed in both groups. After two years, no significant change in movement in the sagittal plane was found in segments with TDR or between the two treatment groups. It remained the same or increased slightly in untreated segments in the TDR group and in this group there was a significant increase in disc height in the operated segments. There was no correlation between segmental movement or disc height and patient-reported outcomes in either group.In this study, insertion of an intervertebral disc prosthesis TDR did not increase movement in the sagittal plane and segmental movement did not correlate with patient-reported outcomes. This suggests that in the lumbar spine the movement preserving properties of TDR are not major determinants of clinical outcomes.

  4. Tracing Planets in Circumstellar Discs

    Directory of Open Access Journals (Sweden)

    Uribe Ana L.

    2013-04-01

    Full Text Available Planets are assumed to form in circumstellar discs around young stellar objects. The additional gravitational potential of a planet perturbs the disc and leads to characteristic structures, i.e. spiral waves and gaps, in the disc density profile. We perform a large-scale parameter study on the observability of these planet-induced structures in circumstellar discs in the (submm wavelength range for the Atacama Large (SubMillimeter Array (ALMA. On the basis of hydrodynamical and magneto-hydrodynamical simulations of star-disc-planet models we calculate the disc temperature structure and (submm images of these systems. These are used to derive simulated ALMA maps. Because appropriate objects are frequent in the Taurus-Auriga region, we focus on a distance of 140 pc and a declination of ≈ 20°. The explored range of star-disc-planet configurations consists of six hydrodynamical simulations (including magnetic fields and different planet masses, nine disc sizes with outer radii ranging from 9 AU to 225 AU, 15 total disc masses in the range between 2.67·10-7 M⊙ and 4.10·10-2 M⊙, six different central stars and two different grain size distributions, resulting in 10 000 disc models. At almost all scales and in particular down to a scale of a few AU, ALMA is able to trace disc structures induced by planet-disc interaction or the influence of magnetic fields in the wavelength range between 0.4...2.0 mm. In most cases, the optimum angular resolution is limited by the sensitivity of ALMA. However, within the range of typical masses of protoplane tary discs (0.1 M⊙...0.001 M⊙ the disc mass has a minor impact on the observability. At the distance of 140 pc it is possible to resolve discs down to 2.67·10-6 M⊙ and trace gaps in discs with 2.67·10-4 M⊙ with a signal-to-noise ratio greater than three. In general, it is more likely to trace planet-induced gaps in magneto-hydrodynamical disc models, because gaps are wider in the presence of

  5. Electromagnetic versus Lense-Thirring alignment of black hole accretion discs

    Science.gov (United States)

    Polko, Peter; McKinney, Jonathan C.

    2017-01-01

    Accretion discs and black holes (BHs) have angular momenta that are generally misaligned, which can lead to warped discs and bends in any jets produced. We examine whether a disc that is misaligned at large radii can be aligned more efficiently by the torque of a Blandford-Znajek (BZ) jet than by Lense-Thirring (LT) precession. To obtain a strong result, we will assume that these torques maximally align the disc, rather than cause precession, or disc tearing. We consider several disc states that include radiatively inefficient thick discs, radiatively efficient thin discs, and super-Eddington accretion discs. The magnetic field strength of the BZ jet is chosen as either from standard equipartition arguments or from magnetically arrested disc (MAD) simulations. We show that standard thin accretion discs can reach spin-disc alignment out to large radii long before LT would play a role, due to the slow infall time that gives even a weak BZ jet time to align the disc. We show that geometrically thick radiatively inefficient discs and super-Eddington discs in the MAD state reach spin-disc alignment near the BH when density profiles are shallow as in magnetohydrodynamical simulations, while the BZ jet aligns discs with steep density profiles (as in advection-dominated accretion flows) out to larger radii. Our results imply that the BZ jet torque should affect the cosmological evolution of BH spin magnitude and direction, spin measurements in active galactic nuclei and X-ray binaries, and the interpretations for Event Horizon Telescope observations of discs or jets in strong-field gravity regimes.

  6. Evolution of Protoplanetary Discs with Magnetically Driven Disc Winds

    CERN Document Server

    Suzuki, Takeru K; Morbidelli, Alessandro; Crida, Aurélien; Guillot, Tristan

    2016-01-01

    Aims: We investigate the evolution of protoplanetary discs (PPDs hereafter) with magnetically driven disc winds and viscous heating. Methods: We consider an initially massive disc with ~0.1 Msun to track the evolution from the early stage of PPDs. We solve the time evolution of surface density and temperature by taking into account viscous heating and the loss of the mass and the angular momentum by the disc winds within the framework of a standard alpha model for accretion discs. Our model parameters, turbulent viscosity, disc wind mass loss, and disc wind torque, which are adopted from local magnetohydrodynamical simulations and constrained by the global energetics of the gravitational accretion, largely depends on the physical condition of PPDs, particularly on the evolution of the vertical magnetic flux in weakly ionized PPDs. Results: Although there are still uncertainties concerning the evolution of the vertical magnetic flux remaining, surface densities show a large variety, depending on the combinatio...

  7. Satellites in discs regulating the accretion luminosity

    CERN Document Server

    Syer, D; Syer, Dave; Clarke, Cathie

    1995-01-01

    We demonstrate, using a simple analytic model, that the presence of a massive satellite can globally modify the structure and emission properties of an accretion disc to which it is tidally coupled. We show, using two levels of numerical approximation, that the analytic model gives reasonable results. The results are applicable to two astrophysical situations. In the case of an active galactic nucleus, we consider the case of a \\sim 10^3\\Msun compact companion to the central black-hole and show that it could modulate the emitted spectrum on a timescale of \\sim10^5 years. In the case of a T Tauri accretion disc, a satellite such as a sub-dwarf or giant planet could modify the disc spectral energy distribution over a substantial fraction of the T Tauri star lifetime.

  8. Counter-Rotating Accretion Discs

    OpenAIRE

    Dyda, Sergei; Lovelace, Richard V. E.; Ustyugova, Galina V.; Romanova, Marina M.; Koldoba, Alexander V.

    2014-01-01

    Counter-rotating discs can arise from the accretion of a counter-rotating gas cloud onto the surface of an existing co-rotating disc or from the counter-rotating gas moving radially inward to the outer edge of an existing disc. At the interface, the two components mix to produce gas or plasma with zero net angular momentum which tends to free-fall towards the disc center. We discuss high-resolution axisymmetric hydrodynamic simulations of a viscous counter-rotating disc for cases where the tw...

  9. Wind interactions above accretion discs: a model for broad-line regions and collimated outflow

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.D.; Raine, D.J. (Leicester Univ. (UK). Dept. of Astronomy)

    1985-01-15

    The interaction of a wind from an active galactic nucleus with a Compton-heating-induced wind from an accretion disc is studied. The nuclear wind is taken as initially supersonic and spherically symmetric. The disc wind arises when the disc surface is exposed to a hard and powerful X-ray source. Three classes of interaction are identified in terms of the relation between the pressure on the disc surface and the corresponding thermal and ram pressures in the nuclear wind.

  10. 人工颈椎间盘假体高度对置换节段活动度影响的生物力学研究%Effect of different heights of artificial cervical disc replacement on the range of motion of the treated segment

    Institute of Scientific and Technical Information of China (English)

    娄纪刚; 刘浩; 李元超; 武文杰; 孟阳; 杨运北; 戎鑫

    2016-01-01

    目的 探讨采用不同高度的人工颈椎间盘假体进行间盘置换术后手术节段活动度的变化规律.方法 收集9具男性新鲜尸体颈椎标本,术前均行颈椎正位、侧位X线片,分别测量C5.6椎间隙高度,并筛选高度为5 mm左右的标本3具进行自身对照实验,先后依次进行完整颈椎组、C5.6节段合适高度(5 mm)人工椎间盘置换组、高度增加1 mm(6 mm)人工椎间盘置换组和增加2 mm(7 mm)人工椎间盘置换组颈椎标本模型的生物力学测试.将标本固定于脊柱三维运动试验机,予75 N跟随载荷,前屈、后伸、左/右侧弯、左/右轴向旋转均施加2 Nm纯力矩载荷,在0.2 Nm/S的变化条件下测量手术节段的活动范围.结果 完整组与5 mm组的前屈、后伸、侧弯及轴向旋转活动范围的差异均无统计学意义;6mm组前屈/后伸、侧弯及轴向旋转的活动范围均较5 mm组增加,且更加接近完整组活动范围,但差异无统计学意义;7 mm组屈伸活动范围(9.5°±1.0°)明显小于完整组(12.5°±0.9°)、5 mm组(11.3°±0.8°)和6 mm组(11.6°±0.9°),但轴向旋转活动范围(10.4°±1.4°)明显大于5 mm组(8.6°±0.3°),差异有统计学意义,而侧弯活动范围与其他3组相比差异均无统计学意义.结论 人工颈椎间盘置换术中试模时两个相邻高度间盘假体植入均合适时,选择高度增加1 mm的间盘可一定程度改善手术节段的活动范围;而高度增加2 mm的间盘置换则可导致手术节段屈伸活动范围减小,旋转活动范围则有增加的趋势.%Objective To cxplore the variation of the range of motion (ROM) of operative level after different heights of artificial cervical disc replacement,and to provide guidance for clinical work in selecting appropriate height of artificial cervical disc prosthesis.Methods The preoperative cervical anteroposterior and lateral Ⅹ-rays of 9 fresh male cadaveric cervical spine specimens were obtained to measure the

  11. Vibration analysis of atomising discs

    Energy Technology Data Exchange (ETDEWEB)

    Deng, H; Ouyang, H, E-mail: H.Ouyang@liverpool.ac.u [Department of Engineering, University of Liverpool, Liverpool L69 3GH (United Kingdom)

    2009-08-01

    The centrifugal atomisation of metallic melts using a spinning disc is an important process for powder production and spray deposition. In the manufacturing process the high-temperature melt flows down to the surface of the atomising disc spinning at very high speed. It is observed that there is a hydraulic jump of the melt flow prior to atomisation. In this paper, the dynamic model of the atomising disc as a spinning Kirchhoff plate with this hydraulic jump is established. The flowing melt is modelled as moving mass and weight force in the radial direction. Using a Galerkin method, it is found that the vibration properties of the atomising disc vary with the disc clamping ratio. The amplitude of the vibration is largely raised when the clamping ratio is smaller than the critical jump radius ratio. It is also found that the disc vibration is non-stationary before becoming steady and the amplitude decreases with increasing disc speed.

  12. Discs in misaligned binary systems

    CERN Document Server

    Rawiraswattana, Krisada; Goodwin, Simon P

    2016-01-01

    We perform SPH simulations to study precession and changes in alignment between the circumprimary disc and the binary orbit in misaligned binary systems. We find that the precession process can be described by the rigid-disc approximation, where the disc is considered as a rigid body interacting with the binary companion only gravitationally. Precession also causes change in alignment between the rotational axis of the disc and the spin axis of the primary star. This type of alignment is of great important for explaining the origin of spin-orbit misaligned planetary systems. However, we find that the rigid-disc approximation fails to describe changes in alignment between the disc and the binary orbit. This is because the alignment process is a consequence of interactions that involve the fluidity of the disc, such as the tidal interaction and the encounter interaction. Furthermore, simulation results show that there are not only alignment processes, which bring the components towards alignment, but also anti-...

  13. Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro

    Science.gov (United States)

    Tropea, D; Molinos, I; Petit, E; Bellini, S; Nagakura, I; O'Tuathaigh, C; Schorova, L; Mitchell, K J; Waddington, J; Sur, M; Gill, M; Corvin, A P

    2016-01-01

    Major neuropsychiatric disorders are genetically complex but share overlapping etiology. Mice mutant for rare, highly penetrant risk variants can be useful in dissecting the molecular mechanisms involved. The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuropsychiatric conditions. Mice mutant for Disc1 display morphological, functional and behavioral deficits that are consistent with impairments observed across these disorders. Here we report that Disc1 L100P mutants are less able to reorganize cortical circuitry in response to stimulation in vivo. Molecular analysis reveals that the mutants have a reduced expression of PSD95 and pCREB in visual cortex and fail to adjust expression of such markers in response to altered stimulation. In vitro analysis shows that mutants have impaired functional reorganization of cortical neurons in response to selected forms of neuronal stimulation, but there is no altered basal expression of synaptic markers. These findings suggest that DISC1 has a critical role in the reorganization of cortical plasticity and that this phenotype becomes evident only under challenge, even at early postnatal stages. This result may represent an important etiological mechanism in the emergence of neuropsychiatric disorders. PMID:26756905

  14. Changes in serum thyroid hormone levels and thyroid gland activity of artificially maturing female Japanese eel (Anguilla japonica)

    Institute of Scientific and Technical Information of China (English)

    Qu Xiancheng(曲宪成); Massaki Nagae; Sinji Adachi; Kohei Yamauchi

    2003-01-01

    In order to evaluate the involvement of the thyroid gland in reproduction, thyroid func-tioning was described in female cultivated Japanese eel (Anguilla japonica ) in progressive stages of sex-ual maturation induced by chum salmon pituitary homogenate (SPH) treatment. Serum thyroid hor-mones, thyroxine (T4) and triiodothyronine (T3) were also measured in each stage. Thyroid gland ac-tivity (epithelial cell height) was high before SPH injection (previtellogenic stage), further increasing at the early vitellogenic stage, thereafter decreasing to late vitellogenic and migratory nucleus stages. Theprofiles of both T3 and T4 changed during vitellogenesis, being high during previtellogenic and earlyvitellogenic stages, and subsequently declining, thus mimicking thyroid gland activity. These resultssuggest that the thyroid has relation with eel ovarian development during artificial maturation.

  15. Selenium status and GSH-Px activity in semen and blood of boars at different ages used for artificial insemination.

    Science.gov (United States)

    Lasota, B; Błaszczyk, B; Seremak, B; Udała, J

    2004-10-01

    This study was performed to determine the relationship between selenium (Se) content and Se-dependent glutathione peroxidase (GSH-Px) activity in blood and semen, and semen quality of boars at different age used in an artificial insemination (AI) station. Routine macroscopic and microscopic analyses of semen quality were accompanied by measurement of Se content and GSH-Px activity in blood and semen. The Se concentration in blood plasma, seminal fluid and spermatozoa was measured by fluorometric method, the GSH-Px activity by a method based on NADPH-coupled reaction. A total of 155 ejaculates and 58 blood samples were investigated. The results of this study showed that there was no direct relationship between the Se content and GSH-Px activity in blood plasma and semen, and semen quality of sexual matured boars. The mechanisms controlling Se content and GSH-Px activity in blood and semen seem to be independent. The age of boars as a differentiating factor for Se content and GSH-Px activity in blood and semen is possible. It is concluded that a determination of Se status and/or GSH-Px activity in organism before Se supplementation is indicated.

  16. Two-dimensional artificial light-harvesting antennae with predesigned high-order structure and robust photosensitising activity

    Science.gov (United States)

    Feng, Xiao; Ding, Xuesong; Chen, Long; Wu, Yang; Liu, Lili; Addicoat, Matthew; Irle, Stephan; Dong, Yuping; Jiang, Donglin

    2016-09-01

    Highly ordered discrete assemblies of chlorophylls that are found in natural light-harvesting antennae are key to photosynthesis, which converts light energy to chemical energy and is the principal producer of organic matter on Earth. Porphyrins and phthalocyanines, which are analogues of chlorophylls, exhibit a strong absorbance of visible and near-infrared light, respectively. A highly ordered porphyrin-co-phthalocyanine antennae would harvest photons over the entire solar spectrum for chemical transformation. However, such a robust antennae has not yet been synthesised. Herein, we report a strategy that merges covalent bonds and noncovalent forces to produce highly ordered two-dimensional porphyrin-co-phthalocyanine antennae. This methodology enables control over the stoichiometry and order of the porphyrin and phthalocyanine units; more importantly, this approach is compatible with various metalloporphyrin and metallophthalocyanine derivatives and thus may lead to the generation of a broad structural diversity of two-dimensional artificial antennae. These ordered porphyrin-co-phthalocyanine two-dimensional antennae exhibit unique optical properties and catalytic functions that are not available with single-component or non-structured materials. These 2D artificial antennae exhibit exceptional light-harvesting capacity over the entire solar spectrum as a result of a synergistic light-absorption effect. In addition, they exhibit outstanding photosensitising activities in using both visible and near-infrared photons for producing singlet oxygen.

  17. Methodology for optic disc localization

    Directory of Open Access Journals (Sweden)

    Marcos A. Leiva-Vasconcellos

    2014-04-01

    Full Text Available The use of digital images in many areas of society is an activity that has reached a remarkable growth in recent years mainly due to the great development that has occurred in technology around the world. These images have a great use in many branches of medicine because they facilitate the diagnosis by specialists and thus help patients to be diagnosed long before symptoms of the disease begin to manifest. For Ophthalmology, one of the most used images are the digital retinography, If it is used properly will allow the occurrence of eye diseases such as glaucoma and diabetic retinopathy. One of the main elements shown on retinal images are the optic disc, the location and detection is of vital importance for working with different parts of the structure o f the eye. This paper proposes two techniques for locating the optic disc in retinal images based on the combination of multiple filters and applying logical operators. To test the algorithms diaretDB0v11 and DRIVE database were used , as a result of the tests are correctly located the 99.091 % of the images from both repo sitories, and were successfully detected 85 % and 87.143 % of images of DRIVE database and diaretDB0v11 respectively.

  18. Cervical Total Disc Arthroplasty

    OpenAIRE

    Basho, Rahul; Hood, Kenneth A.

    2012-01-01

    Symptomatic adjacent segment degeneration of the cervical spine remains problematic for patients and surgeons alike. Despite advances in surgical techniques and instrumentation, the solution remains elusive. Spurred by the success of total joint arthroplasty in hips and knees, surgeons and industry have turned to motion preservation devices in the cervical spine. By preserving motion at the diseased level, the hope is that adjacent segment degeneration can be prevented. Multiple cervical disc...

  19. Accretion Discs in Blazars

    OpenAIRE

    Jolley, E. J. D.; Kuncic, Z.; Bicknell, G. V.; Wagner, S.(Max-Planck-Institut für Kernphysik, 69117, Heidelberg, Germany)

    2009-01-01

    The characteristic properties of blazars (rapid variability, strong polarization, high brightness) are widely attributed to a powerful relativistic jet oriented close to our line of sight. Despite the spectral energy distributions (SEDs) being strongly jet-dominated, a "big blue bump" has been recently detected in sources known as flat spectrum radio quasars (FSRQs). These new data provide a unique opportunity to observationally test coupled jet-disc accretion models in these extreme sources....

  20. Total disc replacement.

    Science.gov (United States)

    Vital, J-M; Boissière, L

    2014-02-01

    Total disc replacement (TDR) (partial disc replacement will not be described) has been used in the lumbar spine since the 1980s, and more recently in the cervical spine. Although the biomechanical concepts are the same and both are inserted through an anterior approach, lumbar TDR is conventionally indicated for chronic low back pain, whereas cervical TDR is used for soft discal hernia resulting in cervicobrachial neuralgia. The insertion technique must be rigorous, with precise centering in the disc space, taking account of vascular anatomy, which is more complex in the lumbar region, particularly proximally to L5-S1. All of the numerous studies, including prospective randomized comparative trials, have demonstrated non-inferiority to fusion, or even short-term superiority regarding speed of improvement. The main implant-related complication is bridging heterotopic ossification with resulting loss of range of motion and increased rates of adjacent segment degeneration, although with an incidence lower than after arthrodesis. A sufficiently long follow-up, which has not yet been reached, will be necessary to establish definitively an advantage for TDR, particularly in the cervical spine.

  1. Apsidal precession, disc breaking and viscosity in warped discs

    CERN Document Server

    Nealon, Rebecca; Price, Daniel J; King, Andrew

    2015-01-01

    We demonstrate the importance of general relativistic apsidal precession in warped black hole accretion discs by comparing three - dimensional smoothed particle hydrodynamic simulations in which this effect is first neglected, and then included. If apsidal precession is neglected, we confirm the results of an earlier magnetohydrodynamic simulation which made this assumption, showing that at least in this case the $\\alpha$ viscosity model produces very similar results to those of simulations where angular momentum transport is due to the magnetorotational instability. Including apsidal precession significantly changes the predicted disc evolution. For moderately inclined discs thick enough that tilt is transported by bending waves, we find a disc tilt which is nonzero at the inner disc edge and oscillates with radius, consistent with published analytic results. For larger inclinations we find disc breaking.

  2. Mechanics of Actuated Disc Cutting

    Science.gov (United States)

    Dehkhoda, Sevda; Detournay, Emmanuel

    2017-02-01

    This paper investigates the mechanics of an actuated disc cutter with the objective of determining the average forces acting on the disc as a function of the parameters characterizing its motion. The specific problem considered is that of a disc cutter revolving off-centrically at constant angular velocity around a secondary axis rigidly attached to a cartridge, which is moving at constant velocity and undercutting rock at a constant depth. This model represents an idealization of a technology that has been implemented in a number of hard rock mechanical excavators with the goal of reducing the average thrust force to be provided by the excavation equipment. By assuming perfect conformance of the rock with the actuated disc as well as a prescribed motion of the disc (perfectly rigid machine), the evolution of the contact surface between the disc and the rock during one actuation of the disc can be computed. Coupled with simple cutter/rock interaction models that embody either a ductile or a brittle mode of fragmentation, these kinematical considerations lead to an estimate of the average force on the cartridge and of the partitioning of the energy imparted by the disc to the rock between the actuation mechanism of the disc and the translation of the cartridge on which the actuated disc is attached.

  3. The biomechanical research on the changes of pressures in the C7/T1 intervertebral space after C5/6 cervical artificial disc replacement%C5/6人工颈椎间盘置换后C7/T1椎间隙压力变化的生物力学研究

    Institute of Scientific and Technical Information of China (English)

    李康华; 李思鸿; 李国军; 张俊; 黄跃平

    2009-01-01

    Objective To explore the stress changes of C7/T1 intervertebral space pre-and post C5/6 discectomy and artificial disc replacement.Method Eleven healthy adult fresh muhisegmental cadaveric cervical spine segments were utilized in this investigation and biomechanically evaluated under the following C5/6 conditions:intact spine,discectomy,and Bryan Disc prosthesis implantation.The load,of neutrality and pure moments of axial,flexion,extension,and lateral bending were applied on each group.The stress changes of the inferior (C7/T1)interverlebral space was detected by modified cyclo-shaped miniature transducer.Result Under axial,anteflexion,and lateral bending loading,the discectomy indicated a significant increase in the stress of the inferiorer(C7/T1)intervertebral space,compared to intact condition and CADR(P<0.05).Under extension loading,the discectomy indicated an increase in the stress of the inferiorer(C7/T1)intervertebral space,compared to intact condition(P>0.05).Under axial,flexion,extension and lateral bending loading,the Bryan Disc prosthesis implantation indicate minor increase of the stress in the inferior(C7/T1)intervertebral space to intact condition(P>0.05).Conclusion There was no difference between the C5/6 ADR and intact spine group.The discectomy of the Cs/6 can increase the stress of the C7/T1 intervertebral spaoe.%目的 了解G5/6椎间盘髓核摘除、人工颈椎间盘置换对C7/T1椎间隙内压力的影响.方法 11具新鲜青壮年颈椎尸体标本.按测试的先后次序分为C5/6椎间盘完整组、C5/6椎间盘髓核摘除组和C5/6Bryan人工颈椎间盘置换组,在颈椎标本上施加轴向、侧弯、后伸、前屈分级载荷,测量各组C7/T1椎间隙内的压力并进行分析比较.结果 (1)在轴向、前屈、侧弯三种工况相同载荷下,C5/6椎间盘髓核摘除组C7/T1椎间隙内的压力大于人工椎间盘组与椎间盘完整组(P0.05).(3)C5/6人工椎间盘置换组C7/T1椎间隙内的压力在

  4. Is artificial recharge promoting microbial activity and biodegradation processes in groundwater systems?

    Science.gov (United States)

    Barba Ferrer, Carme; Folch, Albert; Gaju, Núria; Martínez-Alonso, Maira; Carrasquilla, Marc; Grau-Martínez, Alba; Sanchez-Vila, Xavier

    2016-04-01

    Managed Artificial Recharge (MAR) represents a strategic tool for managing water resources, especially during scarce periods. On one hand, it can increase water stored in aquifers and extract it when weather conditions do not permit exclusive exploitation of surface resources. On the other, it allows improve water quality due the processes occurring into the soil whereas water crosses vadose zone. Barcelona (Catalonia, Spain) conurbation is suffering significant quantitative and qualitative groundwater disturbances. For this reason, Sant Vicenç MAR system, constituted by a sedimentation and an infiltration pond, was constructed in 2009 as the strategic water management infrastructure. Compared with other MAR facilities, this infiltration pond has a reactive bed formed by organic compost and local material. The objective is to promote different redox states allowing more and different degradation of chemical compounds than regular MAR systems. In previous studies in the site, physical and hydrochemical parameters demonstrated that there was indeed a degradation of different pollutants. However, to go a step further understanding the different biogeochemical processes and the related degradation processes occurring in the system, we studied the existing microbial communities. So, molecular techniques were applied in water and soil samples in two different scenarios; the first one, when the system was fully operating and the second when the system was not operating during some months. We have specifically compared microbial diversity and richness indexes and both cluster dendrograms obtained from DGGEs analysis made in each sampling campaign.

  5. Manipulation of zebrafish's orientation using artificial cilia in a microchannel with actively adaptive wall design.

    Science.gov (United States)

    Mani, Karthick; Chang Chien, Tsung-Chun; Panigrahi, Bivas; Chen, Chia-Yuan

    2016-11-08

    The zebrafish is a powerful genetic model organism especially in the biomedical chapter for new drug discovery and development. The genetic toolbox which this vertebrate possesses opens a new window to investigate the etiology of human diseases with a high degree genetic similarity. Still, the requirements of laborious and time-consuming of contemporary zebrafish processing assays limit the procedure in carrying out such genetic screen at high throughput. Here, a zebrafish control scheme was initiated which includes the design and validation of a microfluidic platform to significantly increase the throughput and performance of zebrafish larvae manipulation using the concept of artificial cilia actuation. A moving wall design was integrated into this microfluidic platform first time in literature to accommodate zebrafish inside the microchannel from 1 day post-fertilization (dpf) to 6 dpf and can be further extended to 9 dpf for axial orientation control in a rotational range between 0 to 25 degrees at the minimum step of 2-degree increment in a stepwise manner. This moving wall feature was performed through the deflection of shape memory alloy wire embedded inside the microchannel controlled by the electrical waveforms with high accuracy.

  6. Hourly photosynthetically active radiation estimation in Midwestern United States from artificial neural networks and conventional regressions models.

    Science.gov (United States)

    Yu, Xiaolei; Guo, Xulin

    2016-08-01

    The relationship between hourly photosynthetically active radiation (PAR) and the global solar radiation (R s ) was analyzed from data gathered over 3 years at Bondville, IL, and Sioux Falls, SD, Midwestern USA. These data were used to determine temporal variability of the PAR fraction and its dependence on different sky conditions, which were defined by the clearness index. Meanwhile, models based on artificial neural networks (ANNs) were established for predicting hourly PAR. The performance of the proposed models was compared with four existing conventional regression models in terms of the normalized root mean square error (NRMSE), the coefficient of determination (r (2)), the mean percentage error (MPE), and the relative standard error (RSE). From the overall analysis, it shows that the ANN model can predict PAR accurately, especially for overcast sky and clear sky conditions. Meanwhile, the parameters related to water vapor do not improve the prediction result significantly.

  7. Hourly photosynthetically active radiation estimation in Midwestern United States from artificial neural networks and conventional regressions models

    Science.gov (United States)

    Yu, Xiaolei; Guo, Xulin

    2016-08-01

    The relationship between hourly photosynthetically active radiation (PAR) and the global solar radiation ( R s ) was analyzed from data gathered over 3 years at Bondville, IL, and Sioux Falls, SD, Midwestern USA. These data were used to determine temporal variability of the PAR fraction and its dependence on different sky conditions, which were defined by the clearness index. Meanwhile, models based on artificial neural networks (ANNs) were established for predicting hourly PAR. The performance of the proposed models was compared with four existing conventional regression models in terms of the normalized root mean square error (NRMSE), the coefficient of determination ( r 2), the mean percentage error (MPE), and the relative standard error (RSE). From the overall analysis, it shows that the ANN model can predict PAR accurately, especially for overcast sky and clear sky conditions. Meanwhile, the parameters related to water vapor do not improve the prediction result significantly.

  8. Heat distribution in disc brake

    Science.gov (United States)

    Klimenda, Frantisek; Soukup, Josef; Kampo, Jan

    2016-06-01

    This article is deals by the thermal analysis of the disc brake with floating caliper. The issue is solved by numerically. The half 2D model is used for solution in program ADINA 8.8. Two brake discs without the ventilation are solved. One disc is made from cast iron and the second is made from stainless steel. Both materials are an isotropic. By acting the pressure force on the brake pads will be pressing the pads to the brake disc. Speed will be reduced (slowing down). On the contact surface generates the heat, which the disc and pads heats. In the next part of article is comparison the maximum temperature at the time of braking. The temperatures of both materials for brake disc (gray cast iron, stainless steel) are compares. The heat flux during braking for the both materials is shown.

  9. Numbered nasal discs for waterfowl

    Science.gov (United States)

    Bartonek, J.C.; Dane, C.W.

    1964-01-01

    Numbered nasal discs were successfully used in studies requiring large numbers of individually marked waterfowl. The procedure for constructing these discs is outlined. Blue-winged teal (Anas discors) with 5/8-inch discs, and canvasback (Aythya valisineria) and redhead (A. americana) with 3/4-inch discs can be individually identified up to 50 and 80 yards, respectively, with a gunstock-mounted, 20-power spotting scope. The particular value of these markers is their durability, the number of combinations possible, and the apparent absence of behavioral or mortality influence among such species as the blue-winged teal.

  10. Two-level total disc replacement with Mobi-C(r over 3-years

    Directory of Open Access Journals (Sweden)

    Reginald Davis

    2014-01-01

    Full Text Available Objective: To evaluate the safety and effectiveness of two-level total disc replacement (TDR using a Mobi-C(r Cervical Artificial Disc at the 36 month follow-up. Methods: a Prospective, randomized, controlled, multicenter clinical trial of an artificial cervical disc (Mobi-C(r Cervical Artificial Disc was conducted under the Investigational Device Exemptions (IDE and the U.S. Food & Drug Administration (FDA regulations. A total of 339 patients with degenerative disc disease were enrolled to receive either two-level treatment with TDR, or a two-level anterior cervical discectomy and fusion (ACDF as control. The 234 TDR patients and 105 ACDF patients were followed up at regular time points for three years after surgery. Results: At 36 months, both groups demonstrated an improvement in clinical outcome measures and a comparable safety profile. NDI scores, SF-12 PCS scores, patient satisfaction, and overall success indicated greater statistically significant improvement from baseline for the TDR group, in comparison to the ACDF group. The TDR patients experienced lower subsequent surgery rates and a lower rate of adjacent segment degeneration. On average, the TDR patients maintained segmental range of motion through 36 months with no device failure. Conclusion: Results at three-years support TDR as a safe, effective and statistically superior alternative to ACDF for the treatment of degenerative disc disease at two contiguous cervical levels.

  11. Determination of activity concentration of natural and artificial radionuclides in sand samples from mediterranean coast of Antalya in Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Eke, Canel [Akdeniz Univ., Div. of Physics Education, Antalya (Turkey); Akdeniz Univ., Nuekleer Bilimler Uygulama ve Arastirma Merkezi, Antalya (Turkey); Boztosun, Ismail [Akdeniz Univ., Nuekleer Bilimler Uygulama ve Arastirma Merkezi, Antalya (Turkey); Akdeniz Univ., Dept. of Physics, Antalya (Turkey)

    2015-07-15

    In this paper, we attempt to determine the activity concentration of natural and artificial radionuclides in 37 sand samples from the Mediterranean coast of Antalya in Turkey by using a high purity Germanium (HpGe) detector. {sup 238}U, {sup 232}Th, {sup 40}K and {sup 137}Cs activity concentrations, absorbed dose rate, annual effective dose equivalent, radium equivalent activity, external and internal hazard index of sand samples are determined respectively. The average values are 13.43 ± 0.21 Bq/kg, 6.96 ± 0.06 Bq/kg and, 122.46 ± 18.58 Bq/kg, for {sup 238}U, {sup 232}Th and {sup 40}K respectively. Most of the activity concentration values are less than below minimum detection limit for {sup 137}Cs. The average values of the absorbed dose rate D (nGy/h), annual effective dose equivalent AEDE(μSv/y), radium equivalent activity Ra{sub eq} (Bq/kg), external hazard index H{sub ex} and internal hazard index H{sub in} are 15.52 nGy/h, 19.03 μSv/y, 32.81 Bq/kg, 0.09 and 0.12 respectively. It is observed that {sup 238}U, {sup 232}Th, {sup 40}K and {sup 137}Cs activity concentrations, absorbed dose rate, annual effective dose equivalent, radium equivalent activity are in the limit of the published values, external and internal hazard index values are less than unity.

  12. Feeding indices and enzymatic activities of carob moth Ectomyelois ceratoniae (Zeller (Lepidoptera: pyrallidae on two commercial pistachio cultivars and an artificial diet

    Directory of Open Access Journals (Sweden)

    Naeimeh Teimouri

    2015-01-01

    Full Text Available Feeding indices and enzymatic activities of Ectomyelois ceratoniae (Zeller were studied in a growth chamber under controlled conditions (29 ± 2 °C, relative humidity of 70 ± 5% and a photoperiod of 16:8 (L:D hours on two commercial Pistachio cultivars (Akbari and Kalequchi and an artificial diet. Feeding indices of E. ceratoniae larvae differed significantly on three hosts (P < 0.05. The relative consumption rate was calculated to be 5.36 ± 0.009, 11.10 ± 1.49 and 10.631 ± 0.599 (mg/mg/day on artificial diet, Akbari and Kalequchi cultivars, respectively. Carob moth larvae reared on Akbari cultivar showed the highest efficiency of conversion of digested food (ECD (5.64 ± 0.43. The highest amount of efficiency of conversion of ingested food (ECI was obtained on artificial diet but approximate digestibility (AD was the lowest on this diet. The highest enzymatic activities of alpha-amylase, general proteases and lipase were observed in the midgut of larvae reared on artificial diet. Total protein and lipid value were highest in larvae that were reared on artificial diet.

  13. Relativistic Disc lines

    CERN Document Server

    Fabian, A C; Parker, M L

    2014-01-01

    Broad emission lines, particularly broad iron-K lines, are now commonly seen in the X-ray spectra of luminous AGN and Galactic black hole binaries. Sensitive NuSTAR spectra over the energy range of 3-78 keV and high frequency reverberation spectra now confirm that these are relativistic disc lines produced by coronal irradiation of the innermost accretion flow around rapidly spinning black holes. General relativistic effects are essential in explaining the observations. Recent results are briefly reviewed here.

  14. Artificial blood

    Directory of Open Access Journals (Sweden)

    Sarkar Suman

    2008-01-01

    Full Text Available Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.

  15. Artificial blood.

    Science.gov (United States)

    Sarkar, Suman

    2008-07-01

    Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.

  16. Low back pain and degenerative disc disease

    Directory of Open Access Journals (Sweden)

    Jandrić Slavica

    2006-01-01

    Full Text Available Introduction. Various clinical conditions can cause low back pain, and in most cases it is of a degenerative origin. Degenerative disc disease is a common condition which affects young to middle-aged men and women equally. Changes in the mechanical properties of the disc lead to degenerative arthritis in the intervertebral joints, osteophytes, and narrowing the intervertebral foramen or the spinal canal. Pathophysiology. Degenerative cascade, described by Kirkaldy-Willis, is the widely accepted pathophysiologic model describing the degenerative process as it affects the lumbar spine in 3 phases. Diagnosis. There are two forms of low back pain secondary to degenerative disc disease: a lumbalgia and b lumbar radiculopathy. Limitation of movement, problems with balance, pain, loss of reflexes in the extremities, muscle weakness, loss of sensation or other signs of neurological damage can be found on physical examination. For accurate diagnosis, it is often necessary to combine clinical examination and sophisticated technology. Treatment. Coservative treatment consists of rest, physical therapy, pharmacological therapy and injection therapy. Physical rehabilitation with active patient participation is a key approach to treatment of patients with discogenic pain. Physical therapy, occupational therapy and kinesitherapy are important for improving muscle strength, endurance, and flexibility. Disc surgery is performed if surgical intervention is required. .

  17. Reconstructing the star formation history of the Milky Way disc(s) from chemical abundances

    CERN Document Server

    Snaith, O; Di Matteo, P; Lehnert, M D; Combes, F; Katz, D; Gómez, A

    2014-01-01

    We develop a chemical evolution model in order to study the star formation history of the Milky Way. Our model assumes that the Milky Way is formed from a closed box-like system in the inner regions, while the outer parts of the disc experience some accretion. Unlike the usual procedure, we do not fix the star formation prescription (e.g. Kennicutt law) in order to reproduce the chemical abundance trends. Instead, we fit the abundance trends with age in order to recover the star formation history of the Galaxy. Our method enables one to recover with unprecedented accuracy the star formation history of the Milky Way in the first Gyrs, in both the inner (R9-10kpc) discs as sampled in the solar vicinity. We show that, in the inner disc, half of the stellar mass formed during the thick disc phase, in the first 4-5 Gyr. This phase was followed by a significant dip in the star formation activity (at 8-9 Gyr) and a period of roughly constant lower level star formation for the remaining 8 Gyr. The thick disc phase ha...

  18. Prediction of activity coefficients at infinite dilution for organic solutes in ionic liquids by artificial neural network

    Energy Technology Data Exchange (ETDEWEB)

    Nami, Faezeh [Department of Chemistry, Shahid Beheshti University, G.C., Evin-Tehran 1983963113 (Iran, Islamic Republic of); Deyhimi, Farzad, E-mail: f-deyhimi@sbu.ac.i [Department of Chemistry, Shahid Beheshti University, G.C., Evin-Tehran 1983963113 (Iran, Islamic Republic of)

    2011-01-15

    To our knowledge, this work illustrates for the first time the ability of artificial neural network (ANN) to predict activity coefficients at infinite dilution for organic solutes in ionic liquids (ILs). Activity coefficient at infinite dilution ({gamma}{sup {infinity}}) is a useful parameter which can be used for the selection of effective solvent in the separation processes. Using a multi-layer feed-forward network with Levenberg-Marquardt optimization algorithm, the resulting ANN model generated activity coefficient at infinite dilution data over a temperature range of 298 to 363 K. The unavailable input data concerning softness (S) of organic compounds (solutes) and dipole moment ({mu}) of ionic liquids were calculated using GAMESS suites of quantum chemistry programs. The resulting ANN model and its validation are based on the investigation of up to 24 structurally different organic compounds (alkanes, alkenes, alkynes, cycloalkanes, aromatics, and alcohols) in 16 common imidazolium-based ionic liquids, at different temperatures within the range of 298 to 363 K (i.e. a total number of 914 {gamma}{sub Solute}{sup {infinity}}for each IL data point). The results show a satisfactory agreement between the predicted ANN and experimental data, where, the root mean square error (RMSE) and the determination coefficient (R{sup 2}) of the designed neural network were found to be 0.103, 0.996 for training data and 0.128, 0.994 for testing data, respectively.

  19. Application of artificial neural network in precise prediction of cement elements percentages based on the neutron activation analysis

    Science.gov (United States)

    Eftekhari Zadeh, E.; Feghhi, S. A. H.; Roshani, G. H.; Rezaei, A.

    2016-05-01

    Due to variation of neutron energy spectrum in the target sample during the activation process and to peak overlapping caused by the Compton effect with gamma radiations emitted from activated elements, which results in background changes and consequently complex gamma spectrum during the measurement process, quantitative analysis will ultimately be problematic. Since there is no simple analytical correlation between peaks' counts with elements' concentrations, an artificial neural network for analyzing spectra can be a helpful tool. This work describes a study on the application of a neural network to determine the percentages of cement elements (mainly Ca, Si, Al, and Fe) using the neutron capture delayed gamma-ray spectra of the substance emitted by the activated nuclei as patterns which were simulated via the Monte Carlo N-particle transport code, version 2.7. The Radial Basis Function (RBF) network is developed with four specific peaks related to Ca, Si, Al and Fe, which were extracted as inputs. The proposed RBF model is developed and trained with MATLAB 7.8 software. To obtain the optimal RBF model, several structures have been constructed and tested. The comparison between simulated and predicted values using the proposed RBF model shows that there is a good agreement between them.

  20. Novel localized heating technique on centrifugal microfluidic disc with wireless temperature monitoring system.

    Science.gov (United States)

    Joseph, Karunan; Ibrahim, Fatimah; Cho, Jongman

    2015-01-01

    Recent advances in the field of centrifugal microfluidic disc suggest the need for electrical interface in the disc to perform active biomedical assays. In this paper, we have demonstrated an active application powered by the energy harvested from the rotation of the centrifugal microfluidic disc. A novel integration of power harvester disc onto centrifugal microfluidic disc to perform localized heating technique is the main idea of our paper. The power harvester disc utilizing electromagnetic induction mechanism generates electrical energy from the rotation of the disc. This contributes to the heat generation by the embedded heater on the localized heating disc. The main characteristic observed in our experiment is the heating pattern in relative to the rotation of the disc. The heating pattern is monitored wirelessly with a digital temperature sensing system also embedded on the disc. Maximum temperature achieved is 82 °C at rotational speed of 2000 RPM. The technique proves to be effective for continuous heating without the need to stop the centrifugal motion of the disc.

  1. Accretion discs trapped near corotation

    NARCIS (Netherlands)

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states

  2. Tubulin dynamics during the cytoplasmic cohesiveness cycle in artificially activated sea urchin eggs.

    Science.gov (United States)

    Coffe, G; Foucault, G; Raymond, M N; Pudles, J

    1983-12-01

    Sedimentation studies and [3H]colchicine-binding assays have demonstrated a relationship between the cytoplasmic cohesiveness cycles and the changes in tubulin organization in Paracentrotus lividus eggs activated by 2.5 mM procaine. The same amount of tubulin (20-25% of the total egg tubulin) is involved in these cyclic process and appears to undergo polymerization and depolymerization cycles. Electron microscopy studies reveal that the microtubules formed during these cytoplasmic cohesiveness cycles are under a particulate form which is sedimentable at low speed. Activation experiments carried out in the presence of cytochalasin B (CB) show that the increase in the cytoplasmic cohesiveness is highly reduced while tubulin polymerization and depolymerization cycles and pronuclear centration are not affected. Although tubulin or actin polymerization can be independently triggered in procaine-activated eggs, the increase in cytoplasmic cohesiveness requires the polymerization of both proteins. However, the cytoplasmic cohesiveness cycles appear to be regulated by tubulin polymerization and depolymerization cycles.

  3. Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering.

    Science.gov (United States)

    Peurois, François; Veyron, Simon; Ferrandez, Yann; Ladid, Ilham; Benabdi, Sarah; Zeghouf, Mahel; Peyroche, Gérald; Cherfils, Jacqueline

    2017-02-14

    Attachment of active, GTP-bound small GTPases to membranes by post-translational lipid modifications is pivotal for their ability to process and propagate information in cells. However, generating and manipulating lipidated GTPases has remained difficult, which has limited our quantitative understanding of their activation by GEFs and their termination by GAPs. Here we replaced the lipid modification by a histidine tag in eleven full-length, human small GTPases belonging to the Arf, Rho and Rab families, which allowed to tether them to nickel-lipid containing membranes and characterize the kinetics of their activation by GEFs. Remarkably this strategy uncovered large effects of membranes on the efficiency and/or specificity in all systems studied. Notably, it recapitulated the release of autoinhibition of Arf1, Arf3, Arf4, Arf5 and Arf6 GTPases by membranes and revealed that all isoforms are efficiently activated by two GEFs with different regulatory regimes, ARNO and Brag2. It demonstrated that membranes stimulate the GEF activity of Trio towards RhoG by ≈30 fold and Rac1 by ≈10 fold, and uncovered a previously unknown broader specificity towards RhoA and Cdc42 that was undetectable in solution. Finally, it demonstrated that the exceptional affinity of the bacterial RabGEF DrrA for the phosphoinositide PI(4)P delimits the activation of Rab1 to the immediate vicinity of the membrane-bound GEF. Our study thus validates the histidine tag strategy as a potent and simple means to mimic small GTPases lipidation, which opens broad perspectives of applications to uncover regulations brought about by membranes.

  4. Evolution of gas in debris discs

    Science.gov (United States)

    Kral, Quentin; Wyatt, Mark; Pringle, Jim

    2015-12-01

    A non negligible quantity of gas has been discovered in an increasing number of debris disc systems. ALMA high sensitivity and high resolution is changing our perception of the gaseous component of debris discs as CO is discovered in systems where it should be rapidly photodissociated. It implies that there is a replenishment mechanism and that the observed gas is secondary. Past missions such as Herschel probed the atomic part of the gas through O I and C II emission lines. Gas science in debris discs is still in its infancy, and these new observations raise a handful of questions concerning the mechanisms to create the gas and about its evolution in the planetary system when it is released. The latter question will be addressed in this talk as a self-consistent gas evolution scenario is proposed and is compared to observations for the peculiar case of β Pictoris.Our model proposes that carbon and oxygen within debris discs are created due to photodissociation of CO which is itself created from the debris disc dust (due to grain-grain collisions or photodesorption). The evolution of the carbon atoms is modelled as viscous spreading, with viscosity parameterised using an α model. The temperature, ionisation fraction and population levels of carbon are followed with a PDR model called Cloudy, which is coupled to the dynamical viscous α model. Only carbon gets ionised due to its lower ionisation potential than oxygen. The carbon gas disc can end up with a high ionisation fraction due to strong FUV radiation field. A high ionisation fraction means that the magnetorotational instability (MRI) is very active, so that α is very high. Gas density profiles can be worked out for different input parameters such as the α value, the CO input rate, the location of the input and the incoming radiation field. Observability predictions can be made for future observations, and our model is tested on β Pictoris observations. This new gas evolution model fits the carbon and CO

  5. Variability of soil enzyme activities and vegetation succession following boreal forest surface soil transfer to an artificial hill

    Directory of Open Access Journals (Sweden)

    Maarit Niemi

    2014-08-01

    Full Text Available A landfill site in southern Finland was converted into urban green space by covering it with a layer of fresh forest humus transferred from nearby construction sites. The aim was to develop the 70 m high artificial hill into a recreational area with high biodiversity of flora and fauna. Forest humus was used as a source of organic matter, plant roots, seeds, soil fauna and microorganisms in order to enable rapid regeneration of diverse vegetation and soil biological functions. In this study we report the results of three years of monitoring of soil enzyme activity and plant species compositional patterns. Monthly soil samples were taken each year between June and September from four sites on the hill and from two standing reference forests using three replicate plots. Activities of 10 different enzymes, soil organic matter (SOM content, moisture, pH and temperature of the surface layer were monitored. Abundances of vascular plant species were surveyed on the same four hill sites between late May and early September, three times a season in 2004 and 2005. Although the addition of organic soil considerably increased soil enzyme activities (per dw, the activities at the covered hill sites were far lower than in the reference forests. Temporal changes and differences between sites were analysed in more detail per soil organic matter (SOM in order to reveal differences in the quality of SOM. All the sites had a characteristic enzyme activity pattern and two hill sites showed clear temporal changes. The enzyme activities in uncovered topsoil increased, whereas the activities at the covered Middle site decreased, when compared with other sites at the same time. The different trend between Middle and North sites in enzyme activities may reflect differences in humus material transferred to these sites, but difference in the succession of vegetation affects enzyme activities strongly. Middle yielded higher β-sitosterol content in 2004, as an indication

  6. Artificial intelligence

    CERN Document Server

    Ennals, J R

    1987-01-01

    Artificial Intelligence: State of the Art Report is a two-part report consisting of the invited papers and the analysis. The editor first gives an introduction to the invited papers before presenting each paper and the analysis, and then concludes with the list of references related to the study. The invited papers explore the various aspects of artificial intelligence. The analysis part assesses the major advances in artificial intelligence and provides a balanced analysis of the state of the art in this field. The Bibliography compiles the most important published material on the subject of

  7. Artificial urushi.

    Science.gov (United States)

    Kobayashi, S; Uyama, H; Ikeda, R

    2001-11-19

    A new concept for the design and laccase-catalyzed preparation of "artificial urushi" from new urushiol analogues is described. The curing proceeded under mild reaction conditions to produce the very hard cross-linked film (artificial urushi) with a high gloss surface. A new cross-linkable polyphenol was synthesized by oxidative polymerization of cardanol, a phenol derivative from cashew-nut-shell liquid, by enzyme-related catalysts. The polyphenol was readily cured to produce the film (also artificial urushi) showing excellent dynamic viscoelasticity.

  8. Comparison of ripening processes in intact tomato fruit and excised pericarp discs.

    Science.gov (United States)

    Campbell, A D; Huysamer, M; Stotz, H U; Greve, L C; Labavitch, J M

    1990-12-01

    Physiological processes characteristic of ripening in tissues of intact tomato fruit (Lycopersicon esculentum Mill.) were examined in excised pericarp discs. Pericarp discs were prepared from mature-green tomato fruit and stored in 24-well culture plates, in which individual discs could be monitored for color change, ethylene biosynthesis, and respiration, and selected for cell wall analysis. Within the context of these preparation and handling procedures, most whole fruit ripening processes were maintained in pericarp discs. Pericarp discs and matched intact fruit passed through the same skin color stages at similar rates, as expressed in the L(*)a(*)b(*) color space, changing from green (a(*) red (a(*) > 15) in about 6 days. Individual tissues of the pericarp discs changed color in the same sequence seen in intact fruit (exocarp, endocarp, then vascular parenchyma). Discs from different areas changed in the same spatial sequence seen in intact fruit (bottom, middle, top). Pericarp discs exhibited climacteric increases in ethylene biosynthesis and CO(2) production comparable with those seen in intact fruit, but these were more tightly linked to rate of color change, reaching a peak around a(*) = 5. Tomato pericarp discs decreased in firmness as color changed. Cell wall carbohydrate composition changed with color as in intact fruit: the quantity of water-soluble pectin eluted from the starch-free alcohol insoluble substances steadily increased and more tightly bound, water-insoluble, pectin decreased in inverse relationship. The cell wall content of the neutral sugars arabinose, rhamnose, and galactose steadily decreased as color changed. The extractable activity of specific cell wall hydrolases changed as in intact fruit: polygalacturonase activity, not detectable in green discs (a(*) = -5), appeared as discs turned yellow-red (a(*) = 5), and increased another eight-fold as discs became full red (a(*) value +20). Carboxymethyl-cellulase activity, low in extracts

  9. Three-dimentional simulation of flow-induced platelet activation in artificial heart valves

    Science.gov (United States)

    Hedayat, Mohammadali; Asgharzadeh, Hafez; Borazjani, Iman

    2015-11-01

    Since the advent of heart valve, several valve types such as mechanical and bio-prosthetic valves have been designed. Mechanical Heart Valves (MHV) are durable but suffer from thromboembolic complications that caused by shear-induced platelet activation near the valve region. Bio-prosthetic Heart Valves (BHV) are known for better hemodynamics. However, they usually have a short average life time. Realistic simulations of heart valves in combination with platelet activation models can lead to a better understanding of the potential risk of thrombus formation in such devices. In this study, an Eulerian approach is developed to calculate the platelet activation in three-dimensional simulations of flow through MHV and BHV using a parallel overset-curvilinear immersed boundary technique. A curvilinear body-fitted grid is used for the flow simulation through the anatomic aorta, while the sharp-interface immersed boundary method is used for simulation of the Left Ventricle (LV) with prescribed motion. In addition, dynamics of valves were calculated numerically using under-relaxed strong-coupling algorithm. Finally, the platelet activation results for BMV and MHV are compared with each other.

  10. Pattern formation in artificially activated ectoderm (Rana pipiens and Ambystoma punctatum)

    NARCIS (Netherlands)

    Nieuwkoop, P.D.

    1963-01-01

    Presumptive ectoneuroderm of late blastulae or early gastrulae of Rana pipiens was partially activated by short-lasting disaggregation in Ca-free Holtfreter or Niu-Twitty solutions and subsequent reaggregation in normal solutions. The explants usually became dumbbell shaped and consisted respectivel

  11. Modification of soil microbial activity and several hydrolases in a forest soil artificially contaminated with copper

    Science.gov (United States)

    Bellas, Rosa; Leirós, Mā Carmen; Gil-Sotres, Fernando; Trasar-Cepeda, Carmen

    2010-05-01

    Soils have long been exposed to the adverse effects of human activities, which negatively affect soil biological activity. As a result of their functions and ubiquitous presence microorganisms can serve as environmental indicators of soil pollution. Some features of soil microorganisms, such as the microbial biomass size, respiration rate, and enzyme activity are often used as bioindicators of the ecotoxicity of heavy metals. Although copper is essential for microorganisms, excessive concentrations have a negative influence on processes mediated by microorganisms. In this study we measured the response of some microbial indicators to Cu pollution in a forest soil, with the aim of evaluating their potential for predicting Cu contamination. Samples of an Ah horizon from a forest soil under oakwood vegetation (Quercus robur L.) were contaminated in the laboratory with copper added at different doses (0, 120, 360, 1080 and 3240 mg kg-1) as CuCl2×2H2O. The soil samples were kept for 7 days at 25 °C and at a moisture content corresponding to the water holding capacity, and thereafter were analysed for carbon and nitrogen mineralization capacity, microbial biomass C, seed germination and root elongation tests, and for urease, phosphomonoesterase, catalase and ß-glucosidase activities. In addition, carbon mineralization kinetics were studied, by plotting the log of residual C against incubation time, and the metabolic coefficient, qCO2, was estimated. Both organic carbon and nitrogen mineralization were lower in polluted samples, with the greatest decrease observed in the sample contaminated with 1080 mg kg-1. In all samples carbon mineralization followed first order kinetics; the C mineralization constant was lower in contaminated than in uncontaminated samples and, in general, decreased with increasing doses of copper. Moreover, it appears that copper contamination not only reduced the N mineralization capacity, but also modified the N mineralization process, since in

  12. The evolution of self-gravitating accretion discs

    CERN Document Server

    Rice, Ken

    2016-01-01

    It is quite likely that self-gravity will play an important role in the evolution of accretion discs, in particular those around young stars, and those around supermassive black holes. We summarise, here, our current understanding of the evolution of such discs, focussing more on discs in young stellar system, than on discs in active galactic nuclei. We consider the conditions under which such discs may fragment to form bound objects, and when they might, instead, be expected to settle into a quasi-steady, self-regulated state. We also discuss how this understanding may depend on the mass of the disc relative to the mass of the central object, and how it might depend on the presence of external irradiation. Additionally, we consider whether or not fragmentation might be stochastic, where we might expect it to occur in an actual protostellar disc, and if there is any evidence for fragmentation actually playing a role in the formation of planetary-mass bodies. Although there are still a number of outstanding is...

  13. Evolution of an accretion disc in binary black hole systems

    Science.gov (United States)

    Kimura, Shigeo S.; Takahashi, Sanemichi Z.; Toma, Kenji

    2017-03-01

    We investigate evolution of an accretion disc in binary black hole (BBH) systems and possible electromagnetic counterparts of the gravitational waves from mergers of BBHs. Perna et al. proposed a novel evolutionary scenario of an accretion disc in BBHs in which a disc eventually becomes 'dead', i.e. the magnetorotational instability (MRI) becomes inactive. In their scenario, the dead disc survives until a few seconds before the merger event. We improve the dead disc model and propose another scenario, taking account of effects of the tidal torque from the companion and the critical ionization degree for MRI activation more carefully. We find that the mass of the dead disc is much lower than that in the Perna's scenario. When the binary separation sufficiently becomes small, the mass inflow induced by the tidal torque reactivates MRI, restarting mass accretion on to the black hole. We also find that this disc 'revival' happens more than thousands of years before the merger. The mass accretion induced by the tidal torque increases as the separation decreases, and a relativistic jet could be launched before the merger. The emissions from these jets are too faint compared to gamma-ray bursts, but detectable if the merger events happen within ≲10 Mpc or if the masses of the black holes are as massive as ∼105 M⊙.

  14. Intraoral micro-identification discs.

    Science.gov (United States)

    Hansen, R W

    1991-12-01

    Intraoral micro-identification discs have recently been utilized to provide a more permanent method of personal identification. A wafer of plastic or metal with a surface area of 2.5 to 5 mm2 and carrying identifying numbers and/or letters (indicia) is bonded to the buccal enamel surface of the posterior teeth. Personal identification can occur after the I.D. disc is identified and the indicia is read. Reading of photoreduced indicia requires the aid of a microscope subsequent to the removal of the microdisc. In situ reading of disc indicia is possible using low power handheld magnifiers if the size of the indicia approximates 0.3 mm. Computerization is an integral part of non-custom alpha/numeric type designs, but a custom disc carries a name, address, and other specific information unique to the manufacturer. The use of a computer improves access to the database and it decreases the amount of data placed on the disc. Microdisc bases may be fabricated using a mylar type plastic or they may be manufactured from a stainless steel blank. Plastic discs are constructed with an internal sandwich containing the photo-reduced indicia. Metal discs are marked with a photochemical etch or engraved with a computer driven YAG laser. Attachment of the disc to the enamel surface is accomplished by conventional etching and bonding techniques and are typically bonded to the buccal surface of the maxillary first permanent molar or the second primary molar. Clear composite bonding material covers the disc so that salivary contamination does not result in degradation of the indicia. Orthodontic style discs with a mesh back carry laser written information that may be cemented with conventional orthodontic bonding cement. Standardization of the indicia and overall design is considered to be an important aspect of patient and professional acceptance.

  15. The Application of the Acoustic Method to the Exploration of Urban Active Faults and a Comparison with the Artificial Earthquake, and Radar Methods

    Institute of Scientific and Technical Information of China (English)

    Zhao Genmo; Wang Dahong; Ren Feng; Chen Yukun

    2004-01-01

    The depth of upper fault point is the key data for ascertaining the active age of a buried fault on a plain. The difference of depth obtained from same fault may be dozens to several hundred meters when using different geophysical methods. It can result in the absolutely opposite conclusions when judging fault activity. Because of a lack of an artificial earthquake source with wide band and high central-frequency, many kinds of methods have to be used together.The higher the frequency of the artificial earthquake wave, electromagnetic wave and sonic wave, the higher the resolution. However the attenuation is also very fast and the exploration depth is very shallow. The reverse is also true. The frequency of artificial seismic waves is in the tens of Hz. Its exploration depth is big and the resolution is poor. The frequency of radar electromagnetic waves is about a million Hz, indicating that the resolving power is better, but the exploration depth is very shallow.However, the acoustic frequency is thousands of Hz, its resolving power is better than that of the artificial earthquake method and the exploration depth is larger than that of the radar method. So it is suitable for extra-shallow exploration in the thick deposit strata of the Quaternary. The preliminary results detected using the high frequency acoustic method in extra-shallow layers indicates that previous inferences about some fault activity in the easternpart of the North China plain may need to be greatly corrected.

  16. Evolution of protoplanetary discs with magnetically driven disc winds

    Science.gov (United States)

    Suzuki, Takeru K.; Ogihara, Masahiro; Morbidelli, Alessandro; Crida, Aurélien; Guillot, Tristan

    2016-12-01

    Aims: We investigate the evolution of protoplanetary discs (PPDs) with magnetically driven disc winds and viscous heating. Methods: We considered an initially massive disc with 0.1 M⊙ to track the evolution from the early stage of PPDs. We solved the time evolution of surface density and temperature by taking into account viscous heating and the loss of mass and angular momentum by the disc winds within the framework of a standard α model for accretion discs. Our model parameters, turbulent viscosity, disc wind mass-loss, and disc wind torque, which were adopted from local magnetohydrodynamical simulations and constrained by the global energetics of the gravitational accretion, largely depends on the physical condition of PPDs, particularly on the evolution of the vertical magnetic flux in weakly ionized PPDs. Results: Although there are still uncertainties concerning the evolution of the vertical magnetic flux that remains, the surface densities show a large variety, depending on the combination of these three parameters, some of which are very different from the surface density expected from the standard accretion. When a PPD is in a wind-driven accretion state with the preserved vertical magnetic field, the radial dependence of the surface density can be positive in the inner region migration of protoplanets. Conclusions: The variety of our calculated PPDs should yield a wide variety of exoplanet systems.

  17. A comparison of timed artificial insemination and automated activity monitoring with hormone intervention in 3 commercial dairy herds.

    Science.gov (United States)

    Dolecheck, K A; Silvia, W J; Heersche, G; Wood, C L; McQuerry, K J; Bewley, J M

    2016-02-01

    The objective of this study was to compare the reproductive performance of cows inseminated based on automated activity monitoring with hormone intervention (AAM) to cows from the same herds inseminated using only an intensive timed artificial insemination (TAI) program. Cows (n=523) from 3 commercial dairy herds participated in this study. To be considered eligible for participation, cows must have been classified with a body condition score of at least 2.50, but no more than 3.50, passed a reproductive tract examination, and experienced no incidences of clinical, recorded metabolic diseases in the current lactation. Within each herd, cows were balanced for parity and predicted milk yield, then randomly assigned to 1 of 2 treatments: TAI or AAM. Cows assigned to the TAI group were subjected to an ovulation synchronization protocol consisting of presynchronization, Ovsynch, and Resynch for up to 3 inseminations. Cows assigned to the AAM treatment were fitted with a leg-mounted accelerometer (AfiAct Pedometer Plus, Afimilk, Kibbutz Afikim, Israel) at least 10 d before the end of the herd voluntary waiting period (VWP). Cows in the AAM treatment were inseminated at times indicated by the automated alert system for up to 90 d after the VWP. If an open cow experienced no AAM alert for a 39±7-d period (beginning at the end of the VWP), hormone intervention in the form of a single injection of either PGF2α or GnRH (no TAI) was permitted as directed by the herd veterinarian. Subsequent to hormone intervention, cows were inseminated when alerted in estrus by the AAM system. Pregnancy was diagnosed by ultrasound 33 to 46 d after insemination. Pregnancy loss was determined via a second ultrasound after 60 d pregnant. Timed artificial insemination cows experienced a median 11.0 d shorter time to first service. Automated activity-monitored cows experienced a median 17.5-d shorter service interval. No treatment difference in probability of pregnancy to first AI, probability

  18. Artificial Reefs

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An artificial reef is a human-made underwater structure, typically built to promote marine life in areas with a generally featureless bottom, control erosion, block...

  19. Artificial Limbs

    Science.gov (United States)

    ... diabetes. They may cause you to need an amputation. Traumatic injuries, including from traffic accidents and military combat Cancer Birth defects If you are missing an arm or leg, an artificial limb can sometimes replace it. The device, which is ...

  20. Natural - synthetic - artificial!

    DEFF Research Database (Denmark)

    Nielsen, Peter E

    2010-01-01

    The terms "natural," "synthetic" and "artificial" are discussed in relation to synthetic and artificial chromosomes and genomes, synthetic and artificial cells and artificial life.......The terms "natural," "synthetic" and "artificial" are discussed in relation to synthetic and artificial chromosomes and genomes, synthetic and artificial cells and artificial life....

  1. Satellites in Discs: Regulating the Accretion Luminosity

    OpenAIRE

    Syer, Dave; Clarke, Cathie

    1995-01-01

    We demonstrate, using a simple analytic model, that the presence of a massive satellite can globally modify the structure and emission properties of an accretion disc to which it is tidally coupled. We show, using two levels of numerical approximation, that the analytic model gives reasonable results. The results are applicable to two astrophysical situations. In the case of an active galactic nucleus, we consider the case of a $\\sim 10^3\\Msun$ compact companion to the central black-hole and ...

  2. Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.

    Science.gov (United States)

    Nishida, Yuki; Miyamori, Hisashi; Thompson, Erik W; Takino, Takahisa; Endo, Yoshio; Sato, Hiroshi

    2008-11-01

    The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2.

  3. Coevolution of Binaries and Gaseous Discs

    CERN Document Server

    Fleming, David P

    2016-01-01

    The recent discoveries of circumbinary planets by $\\it Kepler$ raise questions for contemporary planet formation models. Understanding how these planets form requires characterizing their formation environment, the circumbinary protoplanetary disc, and how the disc and binary interact and change as a result. The central binary excites resonances in the surrounding protoplanetary disc that drive evolution in both the binary orbital elements and in the disc. To probe how these interactions impact binary eccentricity and disc structure evolution, N-body smooth particle hydrodynamics (SPH) simulations of gaseous protoplanetary discs surrounding binaries based on Kepler 38 were run for $10^4$ binary periods for several initial binary eccentricities. We find that nearly circular binaries weakly couple to the disc via a parametric instability and excite disc eccentricity growth. Eccentric binaries strongly couple to the disc causing eccentricity growth for both the disc and binary. Discs around sufficiently eccentri...

  4. Adaptation to New Microphones Using Artificial Neural Networks With Trainable Activation Functions.

    Science.gov (United States)

    Siniscalchi, Sabato Marco; Salerno, Valerio Mario

    2016-04-14

    Model adaptation is a key technique that enables a modern automatic speech recognition (ASR) system to adjust its parameters, using a small amount of enrolment data, to the nuances in the speech spectrum due to microphone mismatch in the training and test data. In this brief, we investigate four different adaptation schemes for connectionist (also known as hybrid) ASR systems that learn microphone-specific hidden unit contributions, given some adaptation material. This solution is made possible adopting one of the following schemes: 1) the use of Hermite activation functions; 2) the introduction of bias and slope parameters in the sigmoid activation functions; 3) the injection of an amplitude parameter specific for each sigmoid unit; or 4) the combination of 2) and 3). Such a simple yet effective solution allows the adapted model to be stored in a small-sized storage space, a highly desirable property of adaptation algorithms for deep neural networks that are suitable for large-scale online deployment. Experimental results indicate that the investigated approaches reduce word error rates on the standard Spoke 6 task of the Wall Street Journal corpus compared with unadapted ASR systems. Moreover, the proposed adaptation schemes all perform better than simple multicondition training and comparable favorably against conventional linear regression-based approaches while using up to 15 orders of magnitude fewer parameters. The proposed adaptation strategies are also effective when a single adaptation sentence is available.

  5. Artificial Induction of Twinning by an Active Immunization of Beef Cows Against Inhibin Partially Purified from Porcine Seminal Plasma

    Institute of Scientific and Technical Information of China (English)

    YANG Li-guo; ZHANG Ju-nong; WANG Jin-rong; YE Rong; SANG Run-zi; NIU Shu-li; LIU Cheng-hai

    2002-01-01

    Two hundred and seventy multiparous Chinese Yellow cattle (beef) were selected at 1 to 3months postpartum and divided into three groups (90 cows for each). Animals were given both a primary and booster immunizations with a total dose of 3 mg (Group Th) or 1.5 mg (Group Tl) of seminal preparation containing inhibin activity, emulsified with Freund's complete adjuvant and incomplete adjuvant (for booster), at 3 or 4-week intervals. Other cows were treated with the same volume of seminal preparation without inhibin activity as procedures mentioned above to serve as a control (Group C). Artificial inseminations were given twice at 8 - 12 h intervals when the cow was in heat. Jugular venous blood samples were collected from each cow and used to assay the presence of antibody against seminal preparation by double-diffusion in agar precipitation test and to detect the titer of inhibin antibody by an ELISA method. Data from 247 cows showed that 83.9% (73/87) of cows were in estrus and ovulated 89 ova altogether, of which 19 cows ovulated twin ova and 15 cows produced twins in Group Th (n = 87). However, only 61.1% (44/72) of cows in Group Tl (n=72) and 62.5% (55/88) of cows in Group C were in estrus and ovulated 46 and 52 ova altogether respectively.The ovulation rate (1.27 + 0.03), calving rate ( 126.3% ) and twinning rate (26.3%) in Group Th were greater than those in Groups Tl or C (P<0.01). Furthermore, the ovulation rate was associated with antibody titer in sera of immunized animals (r = 0.7507, P <0.01). These results indicate that active immunization of postpartum cows against inhibin purified from porcine seminal plasma may increase the ovulation rate and induce twinning, suggesting the potential to develop a method to improve fertility in cows.

  6. Artificial neural networks to predict 3D spinal posture in reaching and lifting activities; Applications in biomechanical models.

    Science.gov (United States)

    Gholipour, A; Arjmand, N

    2016-09-06

    Spinal posture is a crucial input in biomechanical models and an essential factor in ergonomics investigations to evaluate risk of low back injury. In vivo measurement of spinal posture through the common motion capture techniques is limited to equipped laboratories and thus impractical for workplace applications. Posture prediction models are therefore considered indispensable tools. This study aims to investigate the capability of artificial neural networks (ANNs) in predicting the three-dimensional posture of the spine (S1, T12 and T1 orientations) in various activities. Two ANNs were trained and tested using measurements from spinal postures of 40 male subjects by an inertial tracking device in various static reaching and lifting (of 5kg) activities. Inputs of each ANN were position of the hand load and body height, while outputs were rotations of the three foregoing segments relative to their initial orientation in the neutral upright posture. Effect of posture prediction errors on the estimated spinal loads in symmetric reaching activities was also investigated using a biomechanical model. Results indicated that both trained ANNs could generate outputs (three-dimensional orientations of the segments) from novel sets of inputs that were not included in the training processes (root-mean-squared-error (RMSE)0.95). A graphic user interface was designed and made available to facilitate use of the ANNs. The difference between the mean of each measured angle in a reaching task and the corresponding angle in a lifting task remained smaller than 8°. Spinal loads estimated by the biomechanical model based on the predicted postures were on average different by < 12% from those estimated based on the exact measured postures (RMSE=173 and 35N for the L5-S1 compression and shear loads, respectively).

  7. Active vibration control of flexible cantilever plates using piezoelectric materials and artificial neural networks

    Science.gov (United States)

    Abdeljaber, Osama; Avci, Onur; Inman, Daniel J.

    2016-02-01

    The study presented in this paper introduces a new intelligent methodology to mitigate the vibration response of flexible cantilever plates. The use of the piezoelectric sensor/actuator pairs for active control of plates is discussed. An intelligent neural network based controller is designed to control the optimal voltage applied on the piezoelectric patches. The control technique utilizes a neurocontroller along with a Kalman Filter to compute the appropriate actuator command. The neurocontroller is trained based on an algorithm that incorporates a set of emulator neural networks which are also trained to predict the future response of the cantilever plate. Then, the neurocontroller is evaluated by comparing the uncontrolled and controlled responses under several types of dynamic excitations. It is observed that the neurocontroller reduced the vibration response of the flexible cantilever plate significantly; the results demonstrated the success and robustness of the neurocontroller independent of the type and distribution of the excitation force.

  8. Comparison of pre- and postimplantation development following the application of three artificial activating stimuli in a mouse model with round-headed sperm cells deficient for oocyte activation

    DEFF Research Database (Denmark)

    Vanden Meerschaut, Frauke; Nikiforaki, D.; De Roo, C.

    2013-01-01

    with fertile controls to assess their fertility. MAIN RESULTS AND THE ROLE OF CHANCE The percentage of oocytes showing calcium rises as well as the number of calcium rises per oscillating oocyte were significantly lower in the wobbler group when compared with the WT group (9.3 versus 96% and 2.1 calcium rises...... was significantly lower at weeks 2, 3 and 4 when compared with female pups originating from WT embryos. However, the latter difference was not observed at later time points, nor in the other artificial activating groups. All offspring mated successfully with fertile controls. LIMITATIONS, REASONS FOR CAUTION...... No gross differences were found between strontium chloride, electrical pulses or ionomycin with respect to the pre- and post-implantation development in the wobbler mouse. WHAT IS KNOWN ALREADY Fertilization failure following intra-cytoplasmic sperm injection (ICSI) occurs in 1–3% of the ICSI cycles...

  9. Determination of Active Components in a Natural Herb with Near Infrared Spectroscopy Based on Artificial Neural Networks

    Institute of Scientific and Technical Information of China (English)

    LIU Xue-song; QU Hai-bin; CHENG Yi-yu

    2005-01-01

    The non-linear relationships between the contents of ginsenoside Rg1, Rb1, Rd and Panax notoginseng saponins(PNS) in Panax notoginseng root herb and the near infrared(NIR) diffuse reflectance spectra of the herb were established by means of artificial neural networks(ANNs). Four three-layered perception feed-forward networks were trained with an error back-propagation algorithm. The significant principal components of the NIR spectral data matrix were utilized as the input of the networks. The networks architecture and parameters were selected so as to offer less prediction errors. Relative prediction errors for Rg1, Rb1, Rd and PNS obtained with the optimum ANN models were 8.99%, 6.54%, 8.29%, and 5.17%, respectively, which were superior to those obtained with PLSR methods. It is verified that ANN is a suitable approach to model this complex non-linearity. The developed method is fast, non-destructive and accurate and it provides a new efficient approach for determining the active components in the complex system of natural herbs.

  10. Assessment of in vitro Antacid Activity of Different Root Extracts of Tephrosia purpurea (L) Pers by Modified Artificial Stomach Model

    Institute of Scientific and Technical Information of China (English)

    Sandhya S; Venkata Ramana K; Vinod K R; Chaitanya Rsnakk

    2012-01-01

    Objective: The purpose of the present investigation is to rule out the antacid activity of Tephrosiapurpurea root by in vitro method using a self fabricated and modified artificial stomach model. The reason for selecting in vitro method was to minimize the usage of experimental animals. Method:In this work we have used air bubbles from an aerator to mimic the peristaltic movements of stomach. Sodium bicarbonate and water were used as reference and control respectively. The parameters evaluated were neutralizing effect, duration of neutralization effect and capacity and effect of temperature on pH. We evaluated the potency of the plant by extracting with three solvents in increasing order of polarity. Results: The neutralization effect, duration of neutralization effect and capacity were found to be higher for methanol root extract than sodium bicarbonate, whereas ethyl acetate and chloroform extract produced moderately good response but less when compared to standard drug but higher than water. Conclusion: Hence this plant can be an effective alternative for sodium bicarbonate which is reported to have side effects like edema n the feet, alteration in systemic pH, belching etc.

  11. Experimental characterization of thermally-activated artificial muscles based on coiled nylon fishing lines

    Directory of Open Access Journals (Sweden)

    Antonello Cherubini

    2015-06-01

    Full Text Available The discovery of an innovative class of thermally activated actuators based on twisted polymeric fibres has opened new horizons toward the development of effective devices that can be easily manufactured using inexpensive materials such as fishing lines or sewing threads. These new devices show large deformations when heated together with promising performance in terms of energy and power densities. With the aim of providing information and data useful for the future engineering applications, we present the results of a thermo-mechanical characterization conducted on a specific type of twisted polymeric fibre (i.e. nylon-made coiled actuators that is considered particularly promising. A custom experimental test-bench and procedure have been developed and employed to run isothermal and isometric tensile tests on a set of specimens that are fabricated with a simple and repeatable process. The results of the experiments highlight some important issues related to the response of these actuators such as hysteresis, repeatability, predictability and stored elastic energy.

  12. The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription.

    Science.gov (United States)

    Corbi, N; Libri, V; Fanciulli, M; Tinsley, J M; Davies, K E; Passananti, C

    2000-06-01

    Up-regulation of utrophin gene expression is recognized as a plausible therapeutic approach in the treatment of Duchenne muscular dystrophy (DMD). We have designed and engineered new zinc finger-based transcription factors capable of binding and activating transcription from the promoter of the dystrophin-related gene, utrophin. Using the recognition 'code' that proposes specific rules between zinc finger primary structure and potential DNA binding sites, we engineered a new gene named 'Jazz' that encodes for a three-zinc finger peptide. Jazz belongs to the Cys2-His2 zinc finger type and was engineered to target the nine base pair DNA sequence: 5'-GCT-GCT-GCG-3', present in the promoter region of both the human and mouse utrophin gene. The entire zinc finger alpha-helix region, containing the amino acid positions that are crucial for DNA binding, was specifically chosen on the basis of the contacts more frequently represented in the available list of the 'code'. Here we demonstrate that Jazz protein binds specifically to the double-stranded DNA target, with a dissociation constant of about 32 nM. Band shift and super-shift experiments confirmed the high affinity and specificity of Jazz protein for its DNA target. Moreover, we show that chimeric proteins, named Gal4-Jazz and Sp1-Jazz, are able to drive the transcription of a test gene from the human utrophin promoter.

  13. Accretion discs trapped near corotation

    OpenAIRE

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states over a wide range of parameter space. We find two distinct regions of instability: one related to the buildup and release of mass in the disc outside corotation, and the other to mass storage with...

  14. Ring-Closing and Cross-Metathesis with Artificial Metalloenzymes Created by Covalent Active Site-Directed Hybridization of a Lipase.

    Science.gov (United States)

    Basauri-Molina, Manuel; Verhoeven, Dide G A; van Schaik, Arnoldus J; Kleijn, Henk; Klein Gebbink, Robertus J M

    2015-10-26

    A series of Grubbs-type catalysts that contain lipase-inhibiting phosphoester functionalities have been synthesized and reacted with the lipase cutinase, which leads to artificial metalloenzymes for olefin metathesis. The resulting hybrids comprise the organometallic fragment that is covalently bound to the active amino acid residue of the enzyme host in an orthogonal orientation. Differences in reactivity as well as accessibility of the active site by the functionalized inhibitor became evident through variation of the anchoring motif and substituents on the N-heterocyclic carbene ligand. Such observations led to the design of a hybrid that is active in the ring-closing metathesis and the cross-metathesis of N,N-diallyl-p-toluenesulfonamide and allylbenzene, respectively, the latter being the first example of its kind in the field of artificial metalloenzymes.

  15. Diaphragm paralysis from cervical disc lesions.

    Science.gov (United States)

    Cloward, R B

    1988-01-01

    An opera singer, who "made her living with her diaphragm", developed a post-traumatic unilateral radiculopathy due to cervical disc lesions, C3 to C6. During one year of severe neck and left arm pain she gradually lost the ability to sing difficult operatic passages which brought an end to her music career. Following a three level anterior cervical decompression and fusion, the neck and arm pain was immediately relieved. One week later her voice and singing ability returned to its full strength and power permitting her to resume her activities as a vocalist. The diagnosis of paresis of the left hemi-diaphragm as part of the cervical disc syndrome was implied by postoperative retrospective inference.

  16. On the convective overstability in protoplanetary discs

    CERN Document Server

    Latter, Henrik

    2015-01-01

    This paper explores the driving of low-level hydrodynamical activity in protoplanetary-disc dead zones. A small adverse radial entropy gradient, ordinarily stabilised by rotation, excites oscillatory convection (`convective overstability') when thermal diffusion, or cooling, is neither too strong nor too weak. I revisit the linear theory of the instability, discuss its prevalence in protoplanetary discs, and show that unstable modes are exact nonlinear solutions in the local Boussinesq limit. Overstable modes cannot grow indefinitely, however, as they are subject to a secondary parametric instability that limits their amplitudes to relatively low levels. If parasites set the saturation level of the ensuing turbulence then the convective overstability is probably too weak to drive significant angular momentum transport or to generate vortices. But I also discuss an alternative, and far more vigorous, saturation route that generates radial `layers' or `zonal flows' (witnessed also in semiconvection). Numerical ...

  17. Intervertebral disc (IVD): Structure, degeneration, repair and regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Whatley, Benjamin R.; Wen Xuejun, E-mail: xjwen@clemson.edu

    2012-02-01

    Low back pain affects a large portion of the population, resulting in high care costs for therapy and treatment. One primary cause of low back pain is the degeneration of the intervertebral disc (IVD) resulting in the compression of the spinal nerves and adjacent vertebrae. Exact causes of degeneration are unknown, but it is thought that natural aging, and both biological and genetic factors may play a significant role in the degenerative process. Conventional methods to alleviate low back pain include spinal fusion and artificial disc replacement. Traditional treatments through spinal fusion may eliminate pain yet do not restore disc function and lead to further degeneration of adjacent levels by altering disc biomechanics and natural kinematics. Recently, artificial IVD replacements have started to gain interest, with two IVD implants currently approved in the United States. Although these implants facilitate the preservation of motions and disc space height, they are unable to sustain compressive forces due to their lack of elasticity. In addition, the implants may produce wear debris that can cause osteolysis and other deleterious effects. As an alternative to these conventional approaches, tissue engineered IVD constructs offer the advantage of biointegration while preserving the essential attributes of natural motion and disc space restoration. There is a great need for the development of tissue engineered scaffolds that simulate the natural 3D morphology and microenvironment of the targeted tissue. Scaffolds should facilitate biological transport to satisfy nutrition and waste removal requirements within the IVD. The discrete tissue architectures of the nucleus pulposus (NP) and annulus fibrosus (AF) have posed great challenges to IVD tissue engineering. Current attempts have not been able to satisfy the biological functions and/or mechanical properties of native tissue. Therefore, these current scaffolds are far from satisfactory. This review highlights the

  18. 单节段半限制型Activ-C人工椎间盘置换术的早期疗效观察%Observation of early results after single-level semi-constrained Activ-C cervical disc arthroplasty

    Institute of Scientific and Technical Information of China (English)

    李洪珂; 张长江; 王明君; 杨贤玉; 李来好

    2014-01-01

    目的:观察半限制型Activ-C人工椎间盘置换术治疗单节段颈椎病的早期临床疗效。方法2009年7月至2012年9月,在我院接受Activ-C人工椎间盘置换术并获得随访的单节段颈椎病患者共28例,男18例,女10例,年龄32~62岁,平均45.2岁。采用日本骨科协会(Japaneseorthopedicassociation,JOA)评分、颈椎活动障碍指数(neckdisabilityindex,NDI)和疼痛视觉模拟评分(visualanaloguescale,VAS)评价术后症状改善程度,比较手术前后的颈椎曲度、手术节段活动度变化,观察统计手术并发症情况。结果随访时间12~36个月,平均17.8个月,JOA脊髓功能评分从(8.5±2.5)分增加至(14.8±1.5)分,NDI评分从(24.8±6.9)分下降至(7.3±4.8)分,颈部VAS评分从(6.8±1.3)分下降至(1.2±0.4)分,上肢VAS评分从(7.4±1.2)分下降至(1.1±0.4)分,均有明显改善(P<0.05)。置换节段活动度从术前平均(9.6±4.3)°增加至末次随访时平均(10.8±3.5)°,差异无统计学意义(P>0.05);颈椎整体曲度术前为(12.9±10.5)°,末次随访时为(15.4±9.1)°,但差异无统计学意义(P>0.05)。结论单节段半限制型Activ-C人工椎间盘置换术可有效改善颈椎病患者的临床症状,维持颈椎的生理曲度和活动度,早期临床疗效满意。%Objective To evaluate the early clinical results of semi-constrained Activ-C cervical disc arthroplasty for single-level cervical spondylosis. Methods From July 2009 to September 2012, 28 patients with single-level cervical spondylosis underwent Activ-C cervical disc arthroplasty and were followed up. There were 18 males and 10 females, whose mean age was 45.2 years old ( range: 32-62 years ). The Japanese Orthopedic Association ( JOA ) scores, Neck Disability Index ( NDI ) and Visual Analogue Scale ( VAS ) were used to evaluate the postoperative improvement of symptoms, compare the preoperative and postoperative cervical curvature and segmental

  19. Involvement of wound and climacteric ethylene in ripening avocado discs.

    Science.gov (United States)

    Starrett, D A; Laties, G G

    1991-10-01

    Avocado (Persea americana Mill. cv Hass) discs (3 mm thick) ripened in approximately 72 hours when maintained in a flow of moist air and resembled ripe fruit in texture and taste. Ethylene evolution by discs of early and midseason fruit was characterized by two distinct components, viz. wound ethylene, peaking at approximately 18 hours, and climacteric ethylene, rising to a peak at approximately 72 hours. A commensurate respiratory stimulation accompanied each ethylene peak. Aminoethoxyvinyl glycine (AVG) given consecutively, at once and at 24 hours following disc preparation, prevented wound and climacteric respiration peaks, virtually all ethylene production, and ripening. When AVG was administered for the first 24 hours only, respiratory stimulation and softening (ripening) were retarded by at least a day. When AVG was added solely after the first 24 hours, ripening proceeded as in untreated discs, although climacteric ethylene and respiration were diminished. Propylene given together with AVG led to ripening under all circumstances. 2,5-Norbornadiene given continuously stimulated wound ethylene production, and it inhibited climacteric ethylene evolution, the augmentation of ethylene-forming enzyme activity normally associated with climacteric ethylene, and ripening. 2,5-Norbornadiene given at 24 hours fully inhibited ripening. When intact fruit were pulsed with ethylene for 24 hours before discs were prepared therefrom, the respiration rate, ethylene-forming enzyme activity buildup, and rate of ethylene production were all subsequently enhanced. The evidence suggests that ethylene is involved in all phases of disc ripening. In this view, wound ethylene in discs accelerates events that normally take place over an extended period throughout the lag phase in intact fruit, and climacteric ethylene serves the same ripening function in discs and intact fruit alike.

  20. Modelling Neutral Hydrogen Discs of Spiral Galaxies

    Institute of Scientific and Technical Information of China (English)

    林伟鹏; 洪碧海

    2002-01-01

    We present an analytical model of a neutral hydrogen disc in a spiral galaxy. The gas disc of the spiral galaxy isassumed to have an exponential surface density profile and to be ionized by the cosmic ultraviolet background.To compare with observations, we consider the disc position angle and inclination angle for a line of sight goingthrough the galaxy disc. The HI column densities depend on the strength of ionizing field and disc position andinclination. The model was applied to NGC 3198 and the results were compared with observational data. TheHI disc profile at large disc radii can be tested by further HI observations using radio telescopes with a largeraperture than the present facilities. This HI disc model can be used to predict quasar absorption line systems bygalaxy discs if quasar lines of sight go through the discs.

  1. Debris disc formation induced by planetary growth

    CERN Document Server

    Kobayashi, Hiroshi

    2014-01-01

    Several hundred stars older than 10 million years have been observed to have infrared excesses. These observations are explained by dust grains formed by the collisional fragmentation of hidden planetesimals. Such dusty planetesimal discs are known as debris discs. In a dynamically cold planetesimal disc, collisional coagulation of planetesimals produces planetary embryos which then stir the surrounding leftover planetesimals. Thus, the collisional fragmentation of planetesimals that results from planet formation forms a debris disc. We aim to determine the properties of the underlying planetesimals in debris discs by numerically modelling the coagulation and fragmentation of planetesimal populations. The brightness and temporal evolution of debris discs depend on the radial distribution of planetesimal discs, the location of their inner and outer edges, their total mass, and the size of planetesimals in the disc. We find that a radially narrow planetesimal disc is most likely to result in a debris disc that ...

  2. Eclipse mapping of accretion discs

    CERN Document Server

    Baptista, R

    2000-01-01

    The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations. I summarize the most important results obtained to date and discuss how they have helped to improve our understanding of accretion physics, from testing the theoretical radial brightness temperature distribution and measuring mass accretion rates to showing the evolution of the structure of a dwarf novae disc through its outburst cycle, from isolating the spectrum of a disc wind to revealing the geometry of disc spiral shocks. I end with an outline of the future prospects.

  3. Face-on accretion onto a protoplanetary disc

    Science.gov (United States)

    Wijnen, T. P. G.; Pols, O. R.; Pelupessy, F. I.; Portegies Zwart, S.

    2016-10-01

    Context. Stars are generally born in clustered stellar environments, which can affect their subsequent evolution. An example of this environmental influence can be found in globular clusters (GCs) harbouring multiple stellar populations. An evolutionary scenario in which a second (and possibly higher order) population is formed by the accretion of chemically enriched material onto the low-mass stars in the initial GC population has been suggested to explain the multiple stellar populations. The idea, dubbed early disc accretion, is that the low-mass, pre-main-sequence stars sweep up gas expelled by the more massive stars of the same generation into their protoplanetary disc as they move through the cluster core. The same process could also occur, to a lesser extent, in embedded stellar systems that are less dense. Aims: Using assumptions that represent the (dynamical) conditions in a typical GC, we investigate whether a low-mass star of 0.4 M⊙ surrounded by a protoplanetary disc can accrete a sufficient amount of enriched material to account for the observed abundances in so-called second generation GC stars. In particular, we focus on the gas-loading rate onto the disc and star, as well as on the lifetime and stability of the disc. Methods: We perform simulations at multiple resolutions with two different smoothed particle hydrodynamics codes and compare the results. Each code uses a different implementation of the artificial viscosity. Results: We find that the gas-loading rate is about a factor of two smaller than the rate based on geometric arguments, because the effective cross-section of the disc is smaller than its surface area. Furthermore, the loading rate is consistent for both codes, irrespective of resolution. Although the disc gains mass in the high-resolution runs, it loses angular momentum on a timescale of 104 yr. Two effects determine the loss of (specific) angular momentum in our simulations: (1) continuous ram pressure stripping and (2

  4. Discover cervical disc arthroplasty versus anterior cervical discectomy and fusion in symptomatic cervical disc diseases: A meta-analysis

    Science.gov (United States)

    Shangguan, Lei; Ning, Guang-Zhi; Tang, Yu; Wang, Zhe; Luo, Zhuo-Jing; Zhou, Yue

    2017-01-01

    Objective Symptomatic cervical disc disease (SCDD) is a common degenerative disease, and Discover artificial cervical disc, a new-generation nonconstrained artificial disk, has been developed and performed gradually to treat it. We performed this meta-analysis to compare the efficacy and safety between Discover cervical disc arthroplasty (DCDA) and anterior cervical discectomy and fusion (ACDF) for SCDD. Methods An exhaustive literature search of PubMed, EMBASE, and the Cochrane Library was conducted to identify randomized controlled trials that compared DCDA with ACDF for patients suffering SCDD. A random-effect model was used. Results were reported as standardized mean difference or risk ratio with 95% confidence interval. Results Of 33 articles identified, six studies were included. Compared with ACDF, DCDA demonstrated shorter operation time (P 0.05). Subgroup analyses did not demonstrated significant differences. Conclusion In conclusion, DCDA presented shorter operation time, and better ROM at the operative level. However, no significant differences were observed in blood loss, NDI scores, neck and arm pain scores, JOA scores, secondary surgery procedures and adverse events between the two groups. Additionally, more studies of high quality with mid- to long-term follow-up are required in future. PMID:28358860

  5. The outcome and influence of artificial cervical disc replacement on adjacent non-responsible segment instability in patients with cervical spondylosis%人工颈椎间盘置换的疗效及其对相邻非责任节段失稳的影响

    Institute of Scientific and Technical Information of China (English)

    种涛; 俞兴; 徐林; 贾育松; 李春根; 毕连涌; 柳根哲

    2012-01-01

    Objectives: To investigate the clinical efficacy and imaging results of the adjacent segment instability in patients with cervical spondylosis treated by Bryan cervical disc replacement. Methods: A retrospective review was performed on 9 cases suffering from adjacent segment instability before surgery. All 9 cases underwent Bryan artificial cervical disc arthoplasty and were followed up from July 2005 to January 2009 in our hospital. There were 4 males and 5 females with an average age of 33.5 years (range, 26-43 years). Japanese Orthopaedic Association(JOA) score was 10.16±3.17(7-13), and visual analogue pain scale(VAS) was 4.3±2.7(l-7) before surgery. All patients underwent cervical flexion and extension plain film and cervical MRI before surgery. Imaging instability was confirmed in the adjacent segment, which was asymptomatic. C4/5 replacement, 1 cases instability in C5/6; C5/6 replacement 4 cases, 3 cases instability in C4/5, 1 cases instability in C6/7; C6/7 replacement, 2 cases instability in C5/6. The double segment replacement 2 cases, each 1 cases instability in C4/5, C5/6 and C5/6, C6/7, which both are adjacent to the head-end segment. Clinical outcome of surgery was evaluated by JOA, neck pain VAS and Odom before surgery and at 1 week, 3, 6, 12, 24, 36 months after surgery respectively; the range of motion(ROM) of the surgical segment, adjacent unstable segment, C2-C7 and cervical malalignment were assessed by cervical dynamic X-ray before operation and 3, 6, 12, 24, 36 months after surgery. Results: The JOA score, neck pain VAS were improved significantly at each follow-up 3 months later after surgery compared with those of preoperation, difference was statistically significant(P0.05), while decreased significantly at 24 and 36 months(P<0.05). ROM of implanted segment and cervical curve at 24 and 36 months after operation increased significantly(P<0.05) compared with preoper-ative ones. The postoperative ROM of C2-C7 remained unchanged at each follow

  6. Photon Bubbles in Accretion Discs

    OpenAIRE

    Gammie, Charles F.

    1998-01-01

    We show that radiation dominated accretion discs are likely to suffer from a ``photon bubble'' instability similar to that described by Arons in the context of accretion onto neutron star polar caps. The instability requires a magnetic field for its existence. In an asymptotic regime appropriate to accretion discs, we find that the overstable modes obey the remarkably simple dispersion relation \\omega^2 = -i g k F(B,k). Here g is the vertical gravitational acceleration, B the magnetic field, ...

  7. Artificial Intelligence

    CERN Document Server

    Warwick, Kevin

    2011-01-01

    if AI is outside your field, or you know something of the subject and would like to know more then Artificial Intelligence: The Basics is a brilliant primer.' - Nick Smith, Engineering and Technology Magazine November 2011 Artificial Intelligence: The Basics is a concise and cutting-edge introduction to the fast moving world of AI. The author Kevin Warwick, a pioneer in the field, examines issues of what it means to be man or machine and looks at advances in robotics which have blurred the boundaries. Topics covered include: how intelligence can be defined whether machines can 'think' sensory

  8. Artificial sweeteners

    DEFF Research Database (Denmark)

    Raben, Anne Birgitte; Richelsen, Bjørn

    2012-01-01

    Artificial sweeteners can be a helpful tool to reduce energy intake and body weight and thereby risk for diabetes and cardiovascular diseases (CVD). Considering the prevailing diabesity (obesity and diabetes) epidemic, this can, therefore, be an important alternative to natural, calorie-containin......Artificial sweeteners can be a helpful tool to reduce energy intake and body weight and thereby risk for diabetes and cardiovascular diseases (CVD). Considering the prevailing diabesity (obesity and diabetes) epidemic, this can, therefore, be an important alternative to natural, calorie...

  9. Lumbar disc excision through fenestration

    Directory of Open Access Journals (Sweden)

    Sangwan S

    2006-01-01

    Full Text Available Background : Lumbar disc herniation often causes sciatica. Many different techniques have been advocated with the aim of least possible damage to other structures while dealing with prolapsed disc surgically in the properly selected and indicated cases. Methods : Twenty six patients with clinical symptoms and signs of prolapsed lumbar intervertebral disc having radiological correlation by MRI study were subjected to disc excision by interlaminar fenestration method. Results : The assessment at follow-up showed excellent results in 17 patients, good in 6 patients, fair in 2 patients and poor in 1 patient. The mean preoperative and postoperative Visual Analogue Scores were 9.34 ±0.84 and 2.19 ±0.84 on scale of 0-10 respectively. These were statistically significant (p value< 0.001, paired t test. No significant complications were recorded. Conclusion : Procedures of interlaminar fenestration and open disc excision under direct vision offers sufficient adequate exposure for lumbar disc excision with a smaller incision, lesser morbidity, shorter convalescence, early return to work and comparable overall results in the centers where recent laser and endoscopy facilities are not available.

  10. Resonances in retrograde circumbinary discs

    CERN Document Server

    Nixon, Chris

    2015-01-01

    We analyse the interaction of an eccentric binary with a circular coplanar circumbinary disc that rotates in a retrograde sense with respect to the binary. In the circular binary case, no Lindblad resonances lie within the disc and no Lindblad resonant torques are produced, as was previously known. By analytic means, we show that when the binary orbit is eccentric, there exist components of the gravitational potential of the binary which rotate in a retrograde sense to the binary orbit and so rotate progradely with respect to this disc, allowing a resonant interaction to occur between the binary and the disc. The resulting resonant torques distinctly alter the disc response from the circular binary case. We describe results of three-dimensional hydrodynamic simulations to explore this effect and categorise the response of the disc in terms of modes whose strengths vary as a function of binary mass ratio and eccentricity. These mode strengths are weak compared to the largest mode strengths expected in the prog...

  11. Counter-Rotating Accretion Discs

    CERN Document Server

    Dyda, Sergei; Ustyugova, Galina V; Romanova, Marina M; Koldoba, Alexander V

    2014-01-01

    Counter-rotating discs can arise from the accretion of a counter-rotating gas cloud onto the surface of an existing co-rotating disc or from the counter-rotating gas moving radially inward to the outer edge of an existing disc. At the interface, the two components mix to produce gas or plasma with zero net angular momentum which tends to free-fall towards the disc center. We discuss high-resolution axisymmetric hydrodynamic simulations of a viscous counter-rotating disc for cases where the two components are vertically separated and radially separated. The viscosity is described by an isotropic $\\alpha-$viscosity including all terms in the viscous stress tensor. For the vertically separated components a shear layer forms between them. The middle of this layer free-falls to the disk center. The accretion rates are increased by factors $\\sim 10^2-10^4$ over that of a conventional disc rotating in one direction with the same viscosity. The vertical width of the shear layer and the accretion rate are strongly dep...

  12. Disc piezoelectric ceramic transformers.

    Science.gov (United States)

    Erhart, Jirií; Půlpán, Petr; Doleček, Roman; Psota, Pavel; Lédl, Vít

    2013-08-01

    In this contribution, we present our study on disc-shaped and homogeneously poled piezoelectric ceramic transformers working in planar-extensional vibration modes. Transformers are designed with electrodes divided into wedge, axisymmetrical ring-dot, moonie, smile, or yin-yang segments. Transformation ratio, efficiency, and input and output impedances were measured for low-power signals. Transformer efficiency and transformation ratio were measured as a function of frequency and impedance load in the secondary circuit. Optimum impedance for the maximum efficiency has been found. Maximum efficiency and no-load transformation ratio can reach almost 100% and 52 for the fundamental resonance of ring-dot transformers and 98% and 67 for the second resonance of 2-segment wedge transformers. Maximum efficiency was reached at optimum impedance, which is in the range from 500 Ω to 10 kΩ, depending on the electrode pattern and size. Fundamental vibration mode and its overtones were further studied using frequency-modulated digital holographic interferometry and by the finite element method. Complementary information has been obtained by the infrared camera visualization of surface temperature profiles at higher driving power.

  13. [Artificial neural networks in Neurosciences].

    Science.gov (United States)

    Porras Chavarino, Carmen; Salinas Martínez de Lecea, José María

    2011-11-01

    This article shows that artificial neural networks are used for confirming the relationships between physiological and cognitive changes. Specifically, we explore the influence of a decrease of neurotransmitters on the behaviour of old people in recognition tasks. This artificial neural network recognizes learned patterns. When we change the threshold of activation in some units, the artificial neural network simulates the experimental results of old people in recognition tasks. However, the main contributions of this paper are the design of an artificial neural network and its operation inspired by the nervous system and the way the inputs are coded and the process of orthogonalization of patterns.

  14. ProDisc-C人工椎间盘双节段置换治疗重症颈椎病%ProDisc-C cervical disc two-segment replacement from severe cervical spondylosis

    Institute of Scientific and Technical Information of China (English)

    曾云; 熊敏; 余化龙; 何宁; 王志勇; 刘志刚; 韩珩; 陈森; 郭乐运

    2013-01-01

    Objective To investigate the clinical effect of ProDisc-C cervical disc replacement for two-segment severe cervical spondylosis.Methods Seventeen cases of two-segment severe cervical spondylosis aged from 36-59 years old were treated with artificial cervical disc replacement.The patients were followed up for 24 to 55 months after operation.The visual analogue scale (VAS),Japanese Orthopedic Association (JOA) scores,cervical curvature overall and the range of motion of the replacement segment were evaluated pre-and 3,12 and 24 months post-operation.Results The VAS scores at 3,12 and 24 months post-operation were 3.8 ± 1.9,1.9 ± 0.8 and 1.1 ± 0.4 respectively,which were significantly reduced as compared with pre-operation (6.3 ± 2.7,P < 0.05).The JOA scores at 3,12 and 24 months postoperation were 13.4 ± 1.5,15.2 ± 1.1 and 15.9 ± 1.4 respectively,which were significantly increased as compared with pre-operation (8.7 ± 2.1,P < 0.05).There was no statistically significant difference in the cervical curvature overall before and 24 months after operation (P > 0.05).There was significant difference in the range of motion of the replacement segmentl before and 24 months after operation (P < 0.05).Conclusion The clinical effect of ProDisc-C cervical disc replacement for two-segment severe cervical spondylosis is satisfactory and it can maintain good cervical activity after operation.%目的 观察ProDisc-C人工椎间盘置换治疗双节段重症颈椎病的疗效.方法 对17例双节段重症颈椎病患者进行人工椎间盘置换术,年龄36~59岁,术后随访时间24 ~55个月,手术前后观察视觉模拟评分(VAS)、JOA评分、颈椎整体曲度、置换节段活动度.结果 术后第3、12、24个月VAS评分分别为(3.8±1.9)、(1.9±0.8)、(1.1±0.4)分,与术前(6.3±2.7)分比较差异有统计学意义(P<0.05);术后第3、12、24个月JOA评分分别为(13.4±1.5)、(15.2±1.1)、(15.9±1.4)分,与术前(8.7±2.1)分比

  15. Active Force with Fuzzy Logic Control of a Two-Link Arm Driven by Pneumatic Artificial Muscles

    Institute of Scientific and Technical Information of China (English)

    H. Jahanabadi; M. Mailah; M. Z. Md Zain; H. M. Hooi

    2011-01-01

    In this paper,the practicality and feasibility of Active Force Control (AFC) integrated with Fuzzy Logic(AFCAFL) appliedto a two link planar arm actuated by a pair of Pneumatic Artificial Muscle (PAM) is investigated.The study emphasizes on the application and control of PAM actuators which may be considered as the new generation of actuators comprising fluidic muscle that has high-tension force,high power to weight ratio and high strength in spite of its drawbacks in the form of high nonlinearity behaviour,high hysteresis and time varying parameters.Fuzzy Logic (FL) is used as a technique to estimate the best value of the inertia matrix of robot arm essential for the AFC mechanism that is complemented with a conventional Proportional-Integral-Derivative (PID) control at the outermost loop.A simulation study was first performed followed by an experimental investigation for validation.The experimental study was based on the independent joint tracking control and coordinated motion control of the arm in Cartesian or task space.In the former,the PAM actuated arm is commanded to track the prescribed trajectories due to harmonic excitations at the joints for a given frequency,whereas for the latter,two sets of trajectories with different loadings were considered.A practical rig utilizing a Hardware-In-The-Loop Simulation (H1LS) configuration was developed and a number of experiments were carried out.The results of the experiment and the simulation works were in good agreement,which verified the effectiveness and robustness of the proposed AFCAFL scheme actuated by PAM.

  16. Testing hydrodynamics schemes in galaxy disc simulations

    Science.gov (United States)

    Few, C. G.; Dobbs, C.; Pettitt, A.; Konstandin, L.

    2016-08-01

    We examine how three fundamentally different numerical hydrodynamics codes follow the evolution of an isothermal galactic disc with an external spiral potential. We compare an adaptive mesh refinement code (RAMSES), a smoothed particle hydrodynamics code (SPHNG), and a volume-discretized mesh-less code (GIZMO). Using standard refinement criteria, we find that RAMSES produces a disc that is less vertically concentrated and does not reach such high densities as the SPHNG or GIZMO runs. The gas surface density in the spiral arms increases at a lower rate for the RAMSES simulations compared to the other codes. There is also a greater degree of substructure in the SPHNG and GIZMO runs and secondary spiral arms are more pronounced. By resolving the Jeans length with a greater number of grid cells, we achieve more similar results to the Lagrangian codes used in this study. Other alterations to the refinement scheme (adding extra levels of refinement and refining based on local density gradients) are less successful in reducing the disparity between RAMSES and SPHNG/GIZMO. Although more similar, SPHNG displays different density distributions and vertical mass profiles to all modes of GIZMO (including the smoothed particle hydrodynamics version). This suggests differences also arise which are not intrinsic to the particular method but rather due to its implementation. The discrepancies between codes (in particular, the densities reached in the spiral arms) could potentially result in differences in the locations and time-scales for gravitational collapse, and therefore impact star formation activity in more complex galaxy disc simulations.

  17. Radio Monitoring of Protoplanetary Discs

    Science.gov (United States)

    Ubach, C.; Maddison, S. T.; Wright, C. M.; Wilner, D. J.; Lommen, D. J. P.; Koribalski, B.

    2017-01-01

    Protoplanetary disc systems observed at radio wavelengths often show excess emission above that expected from a simple extrapolation of thermal dust emission observed at short millimetre wavelengths. Monitoring the emission at radio wavelengths can be used to help disentangle the physical mechanisms responsible for this excess, including free-free emission from a wind or jet, and chromospheric emission associated with stellar activity. We present new results from a radio monitoring survey conducted with Australia Telescope Compact Array over the course of several years with observation intervals spanning days, months and years, where the flux variability of 11 T Tauri stars in the Chamaeleon and Lupus star forming regions was measured at 7 and 15 mm and 3 and 6 cm. Results show that for most sources are variable to some degree at 7 mm, indicating the presence of emission mechanisms other than thermal dust in some sources. Additionally, evidence of grain growth to cm-sized pebbles was found for some sources that also have signs of variable flux at 7 mm. We conclude that multiple processes contributing to the emission are common in T Tauri stars at 7 mm and beyond, and that a detection at a single epoch at radio wavelengths should not be used to determine all processes contributing to the emission.

  18. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.

    Science.gov (United States)

    Sawamura, N; Ando, T; Maruyama, Y; Fujimuro, M; Mochizuki, H; Honjo, K; Shimoda, M; Toda, H; Sawamura-Yamamoto, T; Makuch, L A; Hayashi, A; Ishizuka, K; Cascella, N G; Kamiya, A; Ishida, N; Tomoda, T; Hai, T; Furukubo-Tokunaga, K; Sawa, A

    2008-12-01

    Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions. DISC1 is located in several subcellular domains, such as the centrosome and the nucleus, and interacts with various proteins, including NudE-like (NUDEL/NDEL1) and activating transcription factor 4 (ATF4)/CREB2. Nevertheless, a role for DISC1 in vivo remains to be elucidated. Therefore, we have generated a Drosophila model for examining normal functions of DISC1 in living organisms. DISC1 transgenic flies with preferential accumulation of exogenous human DISC1 in the nucleus display disturbance in sleep homeostasis, which has been reportedly associated with CREB signaling/CRE-mediated gene transcription. Thus, in mammalian cells, we characterized nuclear DISC1, and identified a subset of nuclear DISC1 that colocalizes with the promyelocytic leukemia (PML) bodies, a nuclear compartment for gene transcription. Furthermore, we identified three functional cis-elements that regulate the nuclear localization of DISC1. We also report that DISC1 interacts with ATF4/CREB2 and a corepressor N-CoR, modulating CRE-mediated gene transcription.

  19. Application of finite element analysis in biomechanics of artiifcial disc replacement%有限元分析法在研究人工椎间盘置换生物力学中的应用

    Institute of Scientific and Technical Information of China (English)

    孔超; 鲁世保; 张美超

    2014-01-01

    As an important means of theoretical research, ifnite element analysis has been widely used in spinal biomechanics, especially in artiifcial disc replacement. Recent application progress of ifnite element analysis in artificial disc replacement were summarized in this paper, including the establishment of spine model, three-dimensional ( 3D ) model of the artiifcial intervertebral disc and 3D model of the artiifcial cervical and lumbar disc replacement. The advantages, disadvantages and development trends of ifnite element analysis applied in artiifcial disc replacement were also explored.

  20. The life cycles of Be viscous decretion discs: time-dependent modelling of infrared continuum observations

    Science.gov (United States)

    Vieira, R. G.; Carciofi, A. C.; Bjorkman, J. E.; Rivinius, Th.; Baade, D.; Rímulo, L. R.

    2017-01-01

    We apply the viscous decretion disc (VDD) model to interpret the infrared disc continuum emission of 80 Be stars observed in different epochs. In this way, we determined 169 specific disc structures, namely their density scale, ρ0, and exponent, n. We found that the n values range mainly between 1.5 and 3.5, and ρ0 varies between 10-12 and 10-10 g cm-3, with a peak close to the lower value. Our large sample also allowed us to firmly establish that the discs around early-type stars are denser than in late-type stars. Additionally, we estimated the disc mass decretion rates and found that they range between 10-12 and 10-9 M⊙ yr-1. These values are compatible with recent stellar evolution models of fast-rotating stars. One of the main findings of this work is a correlation between the ρ0 and n values. In order to find out whether these relations can be traced back to the evolution of discs or have some other origin, we used the VDD model to calculate temporal sequences under different assumptions for the time profile of the disc mass injection. The results support the hypothesis that the observed distribution of disc properties is due to a common evolutionary path. In particular, our results suggest that the time-scale for disc growth, during which the disc is being actively fed by mass injection episodes, is shorter than the time-scale for disc dissipation, when the disc is no longer fed by the star and dissipates as a result of the viscous diffusion of the disc material.

  1. The life cycles of Be viscous decretion discs: Time-dependent modelling of infrared continuum observations

    Science.gov (United States)

    Vieira, R. G.; Carciofi, A. C.; Bjorkman, J. E.; Rivinius, Th.; Baade, D.; Rímulo, L. R.

    2016-10-01

    We apply the viscous decretion disc (VDD) model to interpret the infrared disc continuum emission of 80 Be stars observed in different epochs. In this way, we determined 169 specific disc structures, namely their density scale, ρ0, and exponent, n. We found that the n values range mainly between 1.5 and 3.5, and ρ0 varies between 10-12 and 10-10 g cm-3, with a peak close to the lower value. Our large sample also allowed us to firmly establish that the discs around early-type stars are denser than in late-type stars. Additionally, we estimated the disc mass decretion rates and found that they range between 10-12 and 10-9 M⊙ yr-1. These values are compatible with recent stellar evolution models of fast-rotating stars. One of the main findings of this work is a correlation between the ρ0 and n values. In order to find out whether these relations can be traced back to the evolution of discs or have some other origin, we used the VDD model to calculate temporal sequences under different assumptions for the time profile of the disc mass injection. The results support the hypothesis that the observed distribution of disc properties is due to a common evolutionary path. In particular, our results suggest that the timescale for disc growth, during which the disc is being actively fed by mass injection episodes, is shorter than the timescale for disc dissipation, when the disc is no longer fed by the star and dissipates as a result of the viscous diffusion of the disc material.

  2. Accretion discs models with the "beta"-viscosity prescription derived from laboratory experiments

    CERN Document Server

    Huré, J M; Zahn, J P; Hur\\'e, Jean-Marc; Richard, Denis; Zahn, Jean-Paul

    2001-01-01

    We examine under which conditions one may apply, to steady state keplerian accretion discs, the "beta"-viscosity prescription which has been derived from rotating shear flow experiments (Richard & Zahn 1999). Using a vertically averaged model, we show that this law may be suitable for all three families of known systems: in young stellar objects, evolved binary stars and Active Galactic Nuclei discs (except in their outer gas pressure dominated regions where turbulence becomes hypersonic). According to the standard criterion for viscous stability, "beta"-discs are always stable throughout. Using realistic opacities and equation of state, we demonstrate that these discs are thermally unstable in the temperature domain where hydrogen recombines, when they are optically thick, and this could lead to limit cycle behavior. Radiation pressure dominated regions are thermally stable, in contrast with "alpha"-discs. This results in a fully stable solution for the innermost parts of AGN discs.

  3. Automatic diagnosis of lumbar disc herniation with shape and appearance features from MRI

    Science.gov (United States)

    Alomari, Raja'S.; Corso, Jason J.; Chaudhary, Vipin; Dhillon, Gurmeet

    2010-03-01

    Intervertebral disc herniation is a major reason for lower back pain (LBP), which is the second most common neurological ailment in the United States. Automation of herniated disc diagnosis reduces the large burden on radiologists who have to diagnose hundreds of cases each day using clinical MRI. We present a method for automatic diagnosis of lumbar disc herniation using appearance and shape features. We jointly use the intensity signal for modeling the appearance of herniated disc and the active shape model for modeling the shape of herniated disc. We utilize a Gibbs distribution for classification of discs using appearance and shape features. We use 33 clinical MRI cases of the lumbar area for training and testing both appearance and shape models. We achieve over 91% accuracy in detection of herniation in a cross-validation experiment with specificity of 91% and sensitivity of 94%.

  4. Effect of artificial ageing using different wood chips on the antioxidant activity, resveratrol and catechin concentration, sensory properties and colour of two Greek red wines.

    Science.gov (United States)

    Gortzi, Olga; Metaxa, Xenia; Mantanis, George; Lalas, Stavros

    2013-12-01

    Two Greek red wines (Syrah and Cabernet) were artificially aged with different wood chips (white oak, red oak, Turkey oak, chestnut, Bosnian pine, cherry, common juniper, common walnut, white mulberry, black locust and apricot). The influence of each wood species was tested for up to 20 days. The optimum duration for the extraction of total polyphenols was 20 days (Syrah) or 10 days (Cabernet) when chips of white oak, chestnut, cherry, white mulberry, black locust and apricot where used. Resveratrol and catechin concentrations ranged within the limits previously reported in literature. A high antioxidant activity was established after 10 days of artificial ageing. The sensory evaluation showed that the best results were produced by the apricot chips after 5 days (Syrah) or black locust and apricot after 5 days (Cabernet). Colour was seen to increase with both time of ageing and number of wood chips added.

  5. Artificial Intelligence.

    Science.gov (United States)

    Lawrence, David R; Palacios-González, César; Harris, John

    2016-04-01

    It seems natural to think that the same prudential and ethical reasons for mutual respect and tolerance that one has vis-à-vis other human persons would hold toward newly encountered paradigmatic but nonhuman biological persons. One also tends to think that they would have similar reasons for treating we humans as creatures that count morally in our own right. This line of thought transcends biological boundaries-namely, with regard to artificially (super)intelligent persons-but is this a safe assumption? The issue concerns ultimate moral significance: the significance possessed by human persons, persons from other planets, and hypothetical nonorganic persons in the form of artificial intelligence (AI). This article investigates why our possible relations to AI persons could be more complicated than they first might appear, given that they might possess a radically different nature to us, to the point that civilized or peaceful coexistence in a determinate geographical space could be impossible to achieve.

  6. Artificial blood.

    OpenAIRE

    1983-01-01

    #Blood substitutes have been developed for almost a century. The various type of artificial blood was continuously available on the market. The theme of this report is to identify the best substitute in emergency situation for some patients and science students. The definition of best is given; thus, as the vital part of the report, the comparison between them is described and discussed. Modified hemoglobin, bovine-based hemoglobin and PFCs are three basic types. In terms of the perfor...

  7. Quantitative structure-activity relationship study of P2X7 receptor inhibitors using combination of principal component analysis and artificial intelligence methods.

    Science.gov (United States)

    Ahmadi, Mehdi; Shahlaei, Mohsen

    2015-01-01

    P2X7 antagonist activity for a set of 49 molecules of the P2X7 receptor antagonists, derivatives of purine, was modeled with the aid of chemometric and artificial intelligence techniques. The activity of these compounds was estimated by means of combination of principal component analysis (PCA), as a well-known data reduction method, genetic algorithm (GA), as a variable selection technique, and artificial neural network (ANN), as a non-linear modeling method. First, a linear regression, combined with PCA, (principal component regression) was operated to model the structure-activity relationships, and afterwards a combination of PCA and ANN algorithm was employed to accurately predict the biological activity of the P2X7 antagonist. PCA preserves as much of the information as possible contained in the original data set. Seven most important PC's to the studied activity were selected as the inputs of ANN box by an efficient variable selection method, GA. The best computational neural network model was a fully-connected, feed-forward model with 7-7-1 architecture. The developed ANN model was fully evaluated by different validation techniques, including internal and external validation, and chemical applicability domain. All validations showed that the constructed quantitative structure-activity relationship model suggested is robust and satisfactory.

  8. Artificial vision.

    Science.gov (United States)

    Zarbin, M; Montemagno, C; Leary, J; Ritch, R

    2011-09-01

    A number treatment options are emerging for patients with retinal degenerative disease, including gene therapy, trophic factor therapy, visual cycle inhibitors (e.g., for patients with Stargardt disease and allied conditions), and cell transplantation. A radically different approach, which will augment but not replace these options, is termed neural prosthetics ("artificial vision"). Although rewiring of inner retinal circuits and inner retinal neuronal degeneration occur in association with photoreceptor degeneration in retinitis pigmentosa (RP), it is possible to create visually useful percepts by stimulating retinal ganglion cells electrically. This fact has lead to the development of techniques to induce photosensitivity in cells that are not light sensitive normally as well as to the development of the bionic retina. Advances in artificial vision continue at a robust pace. These advances are based on the use of molecular engineering and nanotechnology to render cells light-sensitive, to target ion channels to the appropriate cell type (e.g., bipolar cell) and/or cell region (e.g., dendritic tree vs. soma), and on sophisticated image processing algorithms that take advantage of our knowledge of signal processing in the retina. Combined with advances in gene therapy, pathway-based therapy, and cell-based therapy, "artificial vision" technologies create a powerful armamentarium with which ophthalmologists will be able to treat blindness in patients who have a variety of degenerative retinal diseases.

  9. Competitive coordination aggregation for V-shaped [Co3] and disc-like [Co7] complexes: synthesis, magnetic properties and catechol oxidase activity.

    Science.gov (United States)

    Singha Mahapatra, Tufan; Basak, Dipmalya; Chand, Santanu; Lengyel, Jeff; Shatruk, Michael; Bertolasi, Valerio; Ray, Debashis

    2016-09-14

    Unique dependence on the nature of metal salt and reaction conditions for coordination assembly reactions of varying architecture and nuclearity have been identified in V-shaped [Co3L4] and planar disc-like [Co7L6] compounds: [CoL2(μ-L)2(μ-OH2)2(CF3CO2)2] (1) and [Co(μ-L)6(μ-OMe)6]Cl2 (2) (HL = 2-{(3-ethoxypropylimino)methyl}-6-methoxyphenol). At room temperature varying reaction conditions, cobalt-ligand ratios and use of different bases allowed unique types of coordination self-assembly. The synthetic marvel lies in the nature of aggregation with respect to the two unrelated cores in 1 and 2. Complex 1 assumes a V-shaped arrangement bound to L(-), water and a trifluoroacetate anion, while 2 grows around a central Co(II) ion surrounded by a {Co} hexagon bound to methoxide and L(-). Magnetic measurements revealed that the intermetallic interactions are antiferromagnetic in nature in the case of complex 1 and ferromagnetic in the case of 2 involving high spin cobalt(ii) ions with stabilization of the high-spin ground state in the latter case. In MeCN solutions complexes 1 and 2 showed catalytic oxidation of 3,5-di-tert-butylcatechol (3,5-DTBCH2) to 3,5-di-tert-butylbenzoquinone (3,5-DTBQ) in air. The kinetic study in MeCN revealed that with respect to the catalytic turnover number (kcat) 2 is more effective than 1 for oxidation of 3,5-DTBCH2.

  10. Black hole accretion disc impacts

    CERN Document Server

    Pihajoki, Pauli

    2015-01-01

    We present an analytic model for computing the luminosity and spectral evolution of flares caused by a supermassive black hole impacting the accretion disc of another supermassive black hole. Our model includes photon diffusion, emission from optically thin regions and relativistic corrections to the observed spectrum and time-scales. We test the observability of the impact scenario with a simulated population of quasars hosting supermassive black hole binaries. The results indicate that for a moderate binary mass ratio of 0.3, and impact distances of 100 primary Schwarzschild radii, the accretion disc impacts can be expected to equal or exceed the host quasar in brightness at observed wavelength {\\lambda} = 510 nm up to z = 0.6. We conclude that accretion disc impacts may function as an independent probe for supermassive black hole binaries. We release the code used for computing the model light curves to the community.

  11. Coevolution of binaries and circumbinary gaseous discs

    Science.gov (United States)

    Fleming, David P.; Quinn, Thomas R.

    2017-01-01

    The recent discoveries of circumbinary planets by Kepler raise questions for contemporary planet formation models. Understanding how these planets form requires characterizing their formation environment, the circumbinary protoplanetary disc and how the disc and binary interact and change as a result. The central binary excites resonances in the surrounding protoplanetary disc which drive evolution in both the binary orbital elements and in the disc. To probe how these interactions impact binary eccentricity and disc structure evolution, N-body smooth particle hydrodynamics simulations of gaseous protoplanetary discs surrounding binaries based on Kepler 38 were run for 104 binary periods for several initial binary eccentricities. We find that nearly circular binaries weakly couple to the disc via a parametric instability and excite disc eccentricity growth. Eccentric binaries strongly couple to the disc causing eccentricity growth for both the disc and binary. Discs around sufficiently eccentric binaries which strongly couple to the disc develop an m = 1 spiral wave launched from the 1:3 eccentric outer Lindblad resonance which corresponds to an alignment of gas particle longitude of periastrons. All systems display binary semimajor axis decay due to dissipation from the viscous disc.

  12. Impact of molybdenum nanoparticles on survival, activity of enzymes, and chemical elements in Eisenia fetida using test on artificial substrata.

    Science.gov (United States)

    Lebedev, Sviatoslav; Yausheva, Elena; Galaktionova, Lyudmila; Sizova, Elena

    2016-09-01

    The influence of molybdenum oxide nanoparticles (MoO3) on the growth and survival of Eisenia fetida was established. The activity of antioxidant enzymes and changes in concentration of molybdenum in the body of E. fetida were determined. The degree of bacterial bioluminescence inhibition in extracts of substrates and worm was studied using luminescent strain Escherichia coli K12 TG1. The enzymatic activity of substrates before and after exposure with nanoparticles and worms was assessed. Nanoparticles have concentrations of 10, 40, and 500 mg/kg of dry matter, and substrata are made of artificial soil (substrate A) and microcrystalline cellulose (substrate B). Spherical nanoparticles MoO3, yellow in color, with size 92 ± 0.3 nm, Z-potential 42 ± 0.52 mV, molybdenum content 99.8 mass/%, and specific area 12 m(2)/g were used in the study. A significant decrease by 23.3 % in weight was registered (for MoO3 NPs at 500 mg/kg) on substrate A (p ≤ 0.05). On substrate B, the maximum decrease in weight by 20.5, 33.3, and 16.9 % (p ≤ 0.05) was registered at a dose of 10, 40, and 500 mg/kg, respectively; mortality was from 6.6 to 73 %. After the assessment of bacterial bioluminescence inhibition in substrates A and B (extracts) and before worms were put, the toxicity of substrates was established at doses of 40 and 500 mg/kg, expressed in inhibitory concentration (IC) 30 and IC 50 values. Comparatively, on days 7 and 14, after exposure in the presence of E. fetida, no inhibition of bioluminescence was registered in extracts of substrates A and B, indicating the reduction in toxicity of substrates. The initial content of molybdenum in E. fetida was 0.9 ± 0.018 mg/kg of dry matter. The degree of molybdenum accumulation in worm tissue was dependent on the dose and substrate quality. In particular, 2-7 mg/kg of molybdenum accumulated from substrate A, while up to 15 kg/kg of molybdenum accumulated from substrate B (day 7). Molybdenum

  13. Vertebral osteomyelitis without disc involvement

    Energy Technology Data Exchange (ETDEWEB)

    Kamani, I.; Syed, I.; Saifuddin, A. E-mail: asaifuddin@aol.com; Green, R.; MacSweeney, F

    2004-10-01

    Vertebral osteomyelitis is most commonly due to pyogenic or granulomatous infection and typically results in the combined involvement of the intervertebral disc and adjacent vertebral bodies. Non-infective causes include the related conditions of chronic recurrent multifocal osteomyelitis (CRMO) and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Occasionally, these conditions may present purely within the vertebral body, resulting in various combinations of vertebral marrow oedema and sclerosis, destructive lesions of the vertebral body and pathological vertebral collapse, thus mimicking neoplastic disease. This review illustrates the imaging features of vertebral osteomyelitis without disc involvement, with emphasis on magnetic resonance imaging (MRI) findings.

  14. Dead discs, unstable discs and the stars they surround

    Directory of Open Access Journals (Sweden)

    D’Angelo Caroline

    2014-01-01

    Full Text Available Strong stellar magnetic fields significantly alter the behaviour of surrounding accretion discs. Recent work has demonstrated that at low accretion rates a large amount of mass can remain confined in the disc, contrary to the standard assumption that the magnetic field will expel the disc in an outflow (the “propeller regime”. These “dead discs” often become unstable, causing cycles of accretion onto the central star. Here I present the main predictions of this model, and argue that it provides a good explanation for the peculiar behaviour seen in several accreting sources with strong magnetic fields. I will focus in particular on three accreting millisecond X-ray pulsars: SAX J1808.4-3658, NGC 6440 X-2 and IGR J00291+5934. These sources all show low-frequency quasi-periodic oscillations consistent with a variable accretion rate, as well as unusual outburst patterns that suggest gas is confined in the inner disc regions during quiescence.

  15. Synthesis of TiO2 nanoparticles in different thermal conditions and modeling its photocatalytic activity with artificial neural network

    Institute of Scientific and Technical Information of China (English)

    Fatemeh Ghanbary; Nasser Modirshahla; Morteza Khosravi; Mohammad Ali Behnajady

    2012-01-01

    Titanium dioxide (TiO2) nanoparticles were prepared by sol gel route.The preparation parameters were optimized in the removal of 4-nitrophenol (4-NP).All catalysts were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM).An artificial neural network model (ANN) was developed to predict the photocatalytic removal of 4-NP in the presence of TiO2 nanoparticles prepared under desired conditions.The comparison between the predicted results by designed ANN model and the experimental data proved that modeling of the removal process of 4-NP using artificial neural network was a precise method to predict the extent of 4-NP removal under different conditions.

  16. Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia.

    Directory of Open Access Journals (Sweden)

    Antonio Rampino

    Full Text Available Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1, a leading candidate gene for schizophrenia and related psychiatric conditions, in cognitive function. Altered expression of DISC1 and DISC1-interactors has been identified in schizophrenia. Dysregulated expression of DISC1-interactome genes might, therefore, contribute to schizophrenia susceptibility via disruption of molecular systems required for normal cognitive function. Here, the blood RNA expression levels of DISC1 and DISC1-interacting proteins were measured in 63 control subjects. Cognitive function was assessed using neuropsychiatric tests and functional magnetic resonance imaging was used to assess the activity of prefrontal cortical regions during the N-back working memory task, which is abnormal in schizophrenia. Pairwise correlations between gene expression levels and the relationship between gene expression levels and cognitive function and N-back-elicited brain activity were assessed. Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects. We found that DISC1-interactome genes showed correlated expression in the blood of healthy individuals. The expression levels of several interactome members were correlated with cognitive performance and N-back-elicited activity in the prefrontal cortex. In addition, DISC1 and NDEL1 showed decreased expression in schizophrenic subjects compared to healthy controls. Our findings highlight the importance of the coordinated expression of DISC1-interactome genes for normal cognitive function and suggest that dysregulated DISC1 and NDEL1 expression might, in part, contribute to susceptibility for schizophrenia via disruption of prefrontal cortex-dependent cognitive functions.

  17. Radiation of accretion discs: the eclipses

    Energy Technology Data Exchange (ETDEWEB)

    Schwarzenberg-Czerny, A.

    1984-05-01

    Light curves have been calculated for eclipses of the accretion disc in a cataclysmic binary. The Roche geometry of the cool component was taken into account and the stellar atmospheres were interpolated to provide the local spectrum of the radiation from the disc. The dependence of the light curve on the parameters of the disc is discussed.

  18. Photoevaporating transitional discs and molecular cloud cores

    Science.gov (United States)

    Li, Min; Sui, Ning

    2017-04-01

    We investigate the evolution of photoevaporating protoplanetary discs including mass influx from molecular cloud cores. We examine the influence of cloud core properties on the formation and evolution of transitional discs. We use one-dimensional thin disc assumption and calculate the evolution of the protoplanetary disc. The effects of X-ray photoevaporation are also included. Our calculations suggest that most discs should experience the transitional disc phase within 10 Myr. The formation time of a gap and its initial location are functions of the properties of the cloud cores. In some circumstances, discs can open two gaps by photoevaporation alone. The two gaps form when the gas in the disc can expand to large radius and if the mass at large radius is sufficiently small. The surface density profile of the disc determines whether the two gaps can form. Since the structure of a disc is determined by the properties of a molecular cloud core, the core properties determine the formation of two gaps in the disc. We further find that even when the photoevaporation rate is reduced to 10 per cent of the standard value, two gaps can still form in the disc. The only difference is that the formation time is delayed.

  19. Intervertebral disc degeneration in dogs

    NARCIS (Netherlands)

    Bergknut, Niklas

    2011-01-01

    Back pain is common in both dogs and humans, and is often associated with intervertebral disc (IVD) degeneration. The IVDs are essential structures of the spine and degeneration can ultimately result in diseases such as IVD herniation or spinal instability. In order to design new treatments halting

  20. Electromagnetic Levitation of a Disc

    Science.gov (United States)

    Valle, R.; Neves, F.; de Andrade, R., Jr.; Stephan, R. M.

    2012-01-01

    This paper presents a teaching experiment that explores the levitation of a disc of ferromagnetic material in the presence of the magnetic field produced by a single electromagnet. In comparison to the classical experiment of the levitation of a sphere, the main advantage of the proposed laboratory bench is that the uniform magnetic field…

  1. Constraints on Slim Accretion Discs

    Institute of Scientific and Technical Information of China (English)

    CAI Zhen-Yi; GU Wei-Min; LU Ju-Fu

    2008-01-01

    @@ We show that when the gravitational force in the vertical direction is correctly calculated, the well-known Sshaped sequence of thermal equilibrium solutions can be constructed only for small radii of black hole accretion flows, such that slim accretion discs can possibly exist only in the inner regions of these flows.

  2. The magnetorotational instability in debris-disc gas

    Science.gov (United States)

    Kral, Quentin; Latter, Henrik

    2016-09-01

    Debris discs are commonly swathed in gas, which can be observed in UV, in fine structure lines in FIR, and in resolved maps of CO emission. Carbon and oxygen are overabundant in such gas, but it is severely depleted in hydrogen. As a consequence, its ionization fraction is remarkably high, suggesting that magnetohydrodynamic (MHD) processes could be important. In particular, the gas may be subject to the magnetorotational instability (MRI), and indeed, recent modelling of β Pictoris requires an anomalous viscosity to explain the gas's observed radial structure. In this paper, we explore the possibility that the MRI is active in debris-disc gas and responsible for the observed mass transport. We find that non-ideal MHD and dust-gas interactions play a subdominant role, and that linear instability is viable at certain radii. However, owing to low gas densities, the outer parts of the disc could be stabilized by a weak ambient magnetic field, though it is difficult to constrain such a field. Even if the MRI is stabilized by too strong a field, a magnetocentrifugal wind may be launched in its place, and this could lead to equivalent (non-turbulent) transport. Numerical simulations of the vertically stratified MRI in conditions appropriate to the debris-disc gas should be able to determine the nature of the characteristic behaviour at different radii, and decide on the importance of the MRI (and MHD more generally) on the evolution of these discs.

  3. Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.

    Science.gov (United States)

    Talevi, Alan; Enrique, Andrea V; Bruno-Blanch, Luis E

    2012-06-15

    A virtual screening campaign based on application of a topological discriminant function capable of identifying novel anticonvulsant agents indicated several widely-used artificial sweeteners as potential anticonvulsant candidates. Acesulfame potassium, cyclamate and saccharin were tested in the Maximal Electroshock Seizure model (mice, ip), showing moderate anticonvulsant activity. We hypothesized a probable structural link between the receptor responsible of sweet taste and anticonvulsant molecular targets. Bioinformatic tools confirmed a highly significant sequence-similarity between taste-related protein T1R3 and several metabotropic glutamate receptors from different species, including glutamate receptors upregulated in epileptogenesis and certain types of epilepsy.

  4. Disc degeneration: current surgical options

    Directory of Open Access Journals (Sweden)

    C Schizas

    2010-10-01

    Full Text Available Chronic low back pain attributed to lumbar disc degeneration poses a serious challenge to physicians. Surgery may be indicated in selected cases following failure of appropriate conservative treatment. For decades, the only surgical option has been spinal fusion, but its results have been inconsistent. Some prospective trials show superiority over usual conservative measures while others fail to demonstrate its advantages. In an effort to improve results of fusion and to decrease the incidence of adjacent segment degeneration, total disc replacement techniques have been introduced and studied extensively. Short-term results have shown superiority over some fusion techniques. Mid-term results however tend to show that this approach yields results equivalent to those of spinal fusion. Nucleus replacement has gained some popularity initially, but evidence on its efficacy is scarce. Dynamic stabilisation, a technique involving less rigid implants than in spinal fusion and performed without the need for bone grafting, represents another surgical option. Evidence again is lacking on its superiority over other surgical strategies and conservative measures. Insertion of interspinous devices posteriorly, aiming at redistributing loads and relieving pain, has been used as an adjunct to disc removal surgery for disc herniation. To date however, there is no clear evidence on their efficacy. Minimally invasive intradiscal thermocoagulation techniques have also been tried, but evidence of their effectiveness is questioned. Surgery using novel biological solutions may be the future of discogenic pain treatment. Collaboration between clinicians and basic scientists in this multidisciplinary field will undoubtedly shape the future of treating symptomatic disc degeneration.

  5. Study of the shape of an optical window in a super-resolution state by electromagnetic-thermal coupled simulation: Effects of melting of an active layer in an optical disc

    Science.gov (United States)

    Sano, Haruyuki; Shima, Takayuki; Kuwahara, Masashi; Fujita, Yoshiya; Uchiyama, Munehisa; Aono, Yoshiyuki

    2014-04-01

    We performed a multi-physics simulation for the propagation of electromagnetic waves and heat conduction in a super-resolution optical disc that includes an active layer of InSb. Because the change in the optical constant of InSb due to the phase transition is taken into account, the melting of the active layer can be realistically simulated in our calculation. It was found that in the case of an incident light power (P) of 2 mW, a profile of the electric field intensity transmitted through the InSb layer has an asymmetric shape with a narrow peak. This beam-narrowing was suggested to be an essential mechanism of the super-resolution, because a narrower light beam allows the detection of a smaller pit structure than the optical diffraction limit. This beam-narrowing was found to be originating from a small molten region produced in the InSb layer, which works as a mask for light exposure.

  6. Artificial Enzymes, "Chemzymes"

    DEFF Research Database (Denmark)

    Bjerre, Jeannette; Rousseau, Cyril Andre Raphaël; Pedersen, Lavinia Georgeta M;

    2008-01-01

    Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, even today, there are relatively few examples of enzyme models...... that successfully perform Michaelis-Menten catalysis under enzymatic conditions (i.e., aqueous medium, neutral pH, ambient temperature) and for those that do, very high rate accelerations are seldomly seen. This review will provide a brief summary of the recent developments in artificial enzymes, so called...... "Chemzymes", based on cyclodextrins and other molecules. Only the chemzymes that have shown enzyme-like activity that has been quantified by different methods will be mentioned. This review will summarize the work done in the field of artificial glycosidases, oxidases, epoxidases, and esterases, as well...

  7. Radiation from optically thin accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Tylenda, R. (Polska Akademia Nauk, Torun. Pracownia Astrofizyki)

    1981-01-01

    Accretion discs in cataclysmic variables with low rates of mass transfer, M < or approx. 10/sup 16/g s/sup -1/, have outer regions optically thin in continuum. A simple approach that allows one to calculate the radiation spectra from such discs is presented. A great number of disc models has been obtained in order to study the influence of various parameters (accretion rate, outer radius of the disc, inclination angle, mass of the accreting degenerate dwarf, viscosity parameter) of discs on the outgoing continuous spectra, emission lines and the UBV colours.

  8. Essentials of artificial intelligence

    CERN Document Server

    Ginsberg, Matt

    1993-01-01

    Since its publication, Essentials of Artificial Intelligence has beenadopted at numerous universities and colleges offering introductory AIcourses at the graduate and undergraduate levels. Based on the author'scourse at Stanford University, the book is an integrated, cohesiveintroduction to the field. The author has a fresh, entertaining writingstyle that combines clear presentations with humor and AI anecdotes. At thesame time, as an active AI researcher, he presents the materialauthoritatively and with insight that reflects a contemporary, first hand

  9. The properties of external accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Pringle, J.E. (Space Telescope Science Inst., Baltimore, MD (USA))

    1991-02-15

    The properties of external accretion discs (discs with a central source of angular momentum) are explored both analytically and numerically. An illustrative example of the effect of a disc of material around a binary star on the stellar separation is considered. We consider a Greens-function-type solution in which an initial ring of matter is put in orbit around the central binary. We find that the solution splits temporally into three parts. First, the disc evolves as a standard accretion disc unaware of the inner boundary condition. Secondly, the disc interacts with the inner boundary and changes its character to become, thirdly, an outflowing disc which is propelled outwards by the source of angular momentum at the centre. (author).

  10. Twisted accretion discs: Pt. 5; Viscous evolution

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. (Max-Planck-Institut fuer Physik und Astrophysik, Garching (Germany, F.R.). Inst. fuer Astrophysik)

    1990-08-15

    The time-dependence of accretion discs with orbits tilted out of the symmetry plane is studied. The effects of mass inflow modulation, and tilt variation at the disc outer edge, are examined for both circumbinary discs and for discs around compact objects. The appendices extend the numerical work to some analytic examples of tilt diffusion and external forcing effects. It is also shown that the disc must not be treated as a rigid tilted object if global angular momentum is to be conserved. These results are relevant to the problem of long-term periodicities of the light curves in Her X1 and {epsilon} Aur, the S-type symmetry of radio jets, warped gas discs in galaxies and polar rings in Neptune. Twisted discs may also arise in star-forming regions. (author).

  11. Three-level cervical disc herniation

    Directory of Open Access Journals (Sweden)

    St. Iencean Andrei

    2015-09-01

    Full Text Available Multilevel cervical degenerative disc disease is well known in the cervical spine pathology, with radicular syndromes or cervical myelopathy. One or two level cervical herniated disc is common in adult and multilevel cervical degenerative disc herniation is common in the elderly, with spinal stenosis, and have the same cause: the gradual degeneration of the disc. We report the case of a patient with two level cervical disc herniation (C4 – C5 and C5 – C6 treated by anterior cervical microdiscectomy both levels and fusion at C5 – C6; after five years the patient returned with left C7 radiculopathy and MRI provided the image of a left C6 – C7 disc herniation, he underwent an anterior microsurgical discectomy with rapid relief of symptoms. Three-level cervical herniated disc are rare in adults, and the anterior microdiscectomy with or without fusion solve this pathology.

  12. Determination of the intervertebral disc space from CT images of the lumbar spine

    Science.gov (United States)

    Korez, Robert; Å tern, Darko; Likar, Boštjan; Pernuš, Franjo; Vrtovec, Tomaž

    2014-03-01

    Degenerative changes of the intervertebral disc are among the most common causes of low back pain, where for individuals with significant symptoms surgery may be needed. One of the interventions is the total disc replacement surgery, where the degenerated disc is replaced by an artificial implant. For designing implants with good bone contact and continuous force distribution, the morphology of the intervertebral disc space and vertebral body endplates is of considerable importance. In this study we propose a method for the determination of the intervertebral disc space from three-dimensional (3D) computed tomography (CT) images of the lumbar spine. The first step of the proposed method is the construction of a model of vertebral bodies in the lumbar spine. For this purpose, a chain of five elliptical cylinders is initialized in the 3D image and then deformed to resemble vertebral bodies by introducing 25 shape parameters. The parameters are obtained by aligning the chain to the vertebral bodies in the CT image according to image intensity and appearance information. The determination of the intervertebral disc space is finally achieved by finding the planes that fit the endplates of the obtained parametric 3D models, and placing points in the space between the planes of adjacent vertebrae that enable surface reconstruction of the intervertebral disc space. The morphometric analysis of images from 20 subjects yielded 11:3 +/- 2:6, 12:1 +/- 2:4, 12:8 +/- 2:0 and 12:9 +/- 2:7 cm3 in terms of L1-L2, L2-L3, L3-L4 and L4-L5 intervertebral disc space volume, respectively.

  13. Optimization of Fermentation Media for Enhancing Nitrite-oxidizing Activity by Artificial Neural Network Coupling Genetic Algorithm

    Institute of Scientific and Technical Information of China (English)

    罗剑飞; 林炜铁; 蔡小龙; 李敬源

    2012-01-01

    Two artificial intelligence techniques, artificial neural network and genetic algorithm, were applied to optimize the fermentation medium for improving the nitrite oxidization rate of nitrite oxidizing bacteria. Experiments were conducted with the composition of medium components obtained by genetic algorithm, and the experimental data were used to build a BP (back propagation) neural network model. The concentrations of six medium components were used as input vectors, and the nitrite oxidization rate was used as output vector of the model. The BP neural network model was used as the objective function of genetic algorithm to find the optimum medium composition for the maximum nitrite oxidization rate. The maximum nitrite oxidization rate was 0.952 g 2 NO-2-N·(g MLSS)-1·d-1 , obtained at the genetic algorithm optimized concentration of medium components (g·L-1 ): NaCl 0.58, MgSO 4 ·7H 2 O 0.14, FeSO 4 ·7H 2 O 0.141, KH 2 PO 4 0.8485, NaNO 2 2.52, and NaHCO 3 3.613. Validation experiments suggest that the experimental results are consistent with the best result predicted by the model. A scale-up experiment shows that the nitrite degraded completely after 34 h when cultured in the optimum medium, which is 10 h less than that cultured in the initial medium.

  14. Bay11-7082 attenuates neuropathic pain via inhibition of nuclear factor-kappa B and nucleotide-binding domain-like receptor protein 3 inflammasome activation in dorsal root ganglions in a rat model of lumbar disc herniation

    Science.gov (United States)

    Zhang, Ailiang; Wang, Kun; Ding, Lianghua; Bao, Xinnan; Wang, Xuan; Qiu, Xubin; Liu, Jinbo

    2017-01-01

    Lumbar disc herniation (LDH) is an important cause of radiculopathy, but the underlying mechanisms are incompletely understood. Many studies suggested that local inflammation, rather than mechanical compression, results in radiculopathy induced by LDH. On the molecular and cellular level, nuclear factor-kappa B (NF-κB) and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome have been implicated in the regulation of neuroinflammation formation and progression. In this study, the autologous nucleus pulposus (NP) was implanted in the left L5 dorsal root ganglion (DRG) to mimic LDH in rats. We investigated the expression of NF-κB and the components of NLRP3 inflammasome in the DRG neurons in rats. Western blotting and immunofluorescence for the related molecules, including NLRP3, apoptosis-associated speck-like protein containing caspase-1 activator domain (ASC), caspase-1, interleukin (IL)-1β, IL-18, IκBα, p-IκBα, p65, p-p65, and calcitonin gene-related peptide (CGRP) were examined. In the NP-treated group, the activations of NLRP3, ASC, caspase-1, IL-1β, IL-18, p-IκBα, and p-p65 in DRG neurons in rats were elevated at 1 day after surgery, and the peak occurred at 7 days. Treatment with Bay11-7082, an inhibitor of the actions of IKK-β, was able to inhibit expression and activation of the molecules (NLRP3, ASC, caspase-1, IL-1β, IL-18, p-IκBα, and p-p65) and relieve the pain in rats. Our study shows that NF-κB and NLRP3 inflammasome are involved in the maintenance of NP-induced pain, and that Bay11-7082 could alleviate mechanical allodynia and thermal hyperalgesia by inhibiting NF-κB and NLRP3 inflammasome activation.

  15. Centrifugally exhausting discs: an inverse process of disc-like accretion

    Energy Technology Data Exchange (ETDEWEB)

    Kaburaki, O.

    1989-03-01

    A disc-like mass-loss process from rapidly rotating, highly magnetized objects is investigated. Such a disc may be considered as an inverse-type of magnetized accretion discs. The disc plasma flows out radially with the Alfven velocity while it rotates, in the main part of the disc, with Keplerian velocity. The magnetic stress transfers angular momentum from the central spinner to the disc. A considerable fraction of the rotational energy extracted in association with the angular momentum is liberated in the disc through the (effective) Joule dissipation. An almost self-consistent set of analytic expressions is proposed as a solution to the steady-state, resistive MHD equations which are fairly simplified by the assumption of thin disc. The possibility of finding such discs around young neutron stars is briefly discussed with reference to SN 1987A.

  16. Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

    Directory of Open Access Journals (Sweden)

    Klawitter Marina

    2012-08-01

    Full Text Available Abstract Background As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradiscal/epidural injection. The purpose of this study was to investigate the anti-inflammatory and anti-catabolic potential of curcuma, which has been used in the Indian Ayurvedic medicine to treat multiple ailments for a long time. Methods Human disc cells were treated with IL-1β to induce an inflammatory/catabolic cascade. Different extracts of curcuma as well as curcumin (= a component selected based on results with curcuma extracts and HPLC/MS analysis were tested for their ability to reduce mRNA expression of proinflammatory cytokines and matrix degrading enzymes after 6 hours (real-time RT-PCR, followed by analysis of typical inflammatory signaling mechanisms such as NF-κB (Western Blot, Transcription Factor Assay, MAP kinases (Western Blot and Toll-like receptors (real-time RT-PCR. Quantitative data was statistically analyzed using a Mann Whitney U test with a significance level of p  Results Results indicate that the curcuma DMSO extract significantly reduced levels of IL-6, MMP1, MMP3 and MMP13. The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1β, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-α. Pathway analysis indicated that curcumin did not show involvement of NF-κB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK. Conclusions Based on its anti-inflammatory and anti-catabolic effects, intradiscal injection of curcumin may be an attractive treatment alternative. However, whether the anti-inflammatory properties in vitro lead to analgesia in vivo will need to be confirmed in an appropriate animal model.

  17. Grain charging in protoplanetary discs

    CERN Document Server

    Ilgner, Martin

    2011-01-01

    Recent work identified a growth barrier for dust coagulation that originates in the electric repulsion between colliding particles. Depending on its charge state, dust material may have the potential to control key processes towards planet formation such as MHD (magnetohydrodynamic) turbulence and grain growth which are coupled in a two-way process. We quantify the grain charging at different stages of disc evolution and differentiate between two very extreme cases: compact spherical grains and aggregates with fractal dimension D_f = 2. Applying a simple chemical network that accounts for collisional charging of grains, we provide a semi-analytical solution. This allowed us to calculate the equilibrium population of grain charges and the ionisation fraction efficiently. The grain charging was evaluated for different dynamical environments ranging from static to non-stationary disc configurations. The results show that the adsorption/desorption of neutral gas-phase heavy metals, such as magnesium, effects the ...

  18. Superhumps, resonances and accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Whitehurst, R.; King, A. (Leicester Univ. (UK). Dept. of Astronomy)

    1991-03-01

    The structure of accretion discs within binary systems is shown to be influenced by the excitation of resonances within the disc. Of particular importance is that near the 3:1 commensurability with the stars' orbit. This can be used to explain the superhump phenomenon of SU Ursae Majoris dwarf novae in superoutburst. This resonance can only appear for mass ratios which satisfy M{sub 2}/M{sub 1} < {approx equal} 0.25-0.33: for larger mass ratios the available resonances are weaker and of the wrong form to produce the superhump phenomenon. The mass-transfer stream is shown to be an important contributor to the growth rate of the resonance. (author).

  19. Eclipse mapping of accretion discs

    OpenAIRE

    Baptista, Raymundo

    2000-01-01

    The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations. I summarize the most important results obtained to date and discuss how they have helped to improve our understanding of accretion physics, from testing the theoretical radial brightness temperature dist...

  20. Superficial groundwater contamination by artificial radionuclides by the nuclear site of Saluggia (Vercelli, Italy): radiological monitoring activities.

    Science.gov (United States)

    Porzio, Laura

    2009-12-01

    During the last 15 y, by the Saluggia (Vercelli, Italy) nuclear site, episodes of contamination of the superficial groundwater happened due to artificial radionuclides. The local network of radiological monitoring around the nuclear site, managed by Arpa Piemonte from the late 1980s, highlighted the presence of (60)Co, (90)Sr, (137)Cs and (3)H during this period. The object of this paper was to give particular evidence not to analytical aspects, but to the methodical approach used to solve the problems that arose. In fact, the intrinsic hydro-geological vulnerability of the zone, the typology and conditions of the plants (all very old) and the presence of the 'Acquedotto del Monferrato' tap water well field, one of the most important in Piemonte, at approximately 2 km downstream of the site, made the situation very difficult to approach.

  1. Artificial Economy

    Directory of Open Access Journals (Sweden)

    Alexandru JIVAN

    2011-08-01

    Full Text Available This paper proposes to eliminate, a routine in the economic thinking, claimed to be responsible for the negative essence of economic developments, from the point of view, of the ecological implications (employment in the planetary ecosystem. The methodological foundations start from the natural origins of the functionality of the human economic society according to the originary physiocrat liberalism, and from specific natural characteristics of the humankind. This paper begins with a comment-analysis of the difference between natural and artificial within the economy, and then explains some of the most serious diversions from the natural essence of economic liberalism. It shall be explained the original (heterodox interpretation of the Classical political economy (economics, by making calls to the Romanian economic thinking from aggravating past century. Highlighting the destructive impact of the economy - which, under the invoked doctrines, we call unnatural - allows an intuitive presentation of a logical extension of Marshall's market price, based on previous research. Besides the doctrinal arguments presented, the economic realities inventoried along the way (major deficiencies and effects, determined demonstrate the validity of the hypothesis of the unnatural character and therefore necessarily to be corrected, of the concept and of the mechanisms of the current economy.The results of this paper consist of original heterodox methodspresented, intuitive or developed that can be found conclusively within the key proposals for education and regulation.

  2. Magnetorotationally driven wind cycles in local disc models

    Science.gov (United States)

    Riols, A.; Ogilvie, G. I.; Latter, H.; Ross, J. P.

    2016-12-01

    Jets, from the protostellar to the AGN context, have been extensively studied but their connection to the turbulent dynamics of the underlying accretion disc is poorly understood. Following a similar approach to Lesur, Fereira & Ogilvie, we examine the role of the magnetorotational instability (MRI) in the production and acceleration of outflows from discs. Via a suite of 1D shearing-box simulations of stratified discs, we show that magnetocentrifugal winds exhibit cyclic activity with a period of 10-20 Ω-1, a few times the orbital period. The cycle seems to be more vigorous for strong vertical field; it is robust to the variation of relevant parameters and independent of numerical details. The convergence of these solutions (in particular the mass-loss rate) with vertical box size is also studied. By considering a sequence of magnetohydrostatic equilibria and their stability, the periodic activity may be understood as the succession of the following phases: (a) a dominant MRI channel mode, (b) strong magnetic field generation, (c) consequent wind launching, and ultimately (d) vertical expulsion of the excess magnetic field by the expanding and accelerating gas associated with the wind. We discuss potential connections between this behaviour and observed time-variability in disc-jet systems.

  3. Artificial neural networks in neurosurgery.

    Science.gov (United States)

    Azimi, Parisa; Mohammadi, Hasan Reza; Benzel, Edward C; Shahzadi, Sohrab; Azhari, Shirzad; Montazeri, Ali

    2015-03-01

    Artificial neural networks (ANNs) effectively analyze non-linear data sets. The aimed was A review of the relevant published articles that focused on the application of ANNs as a tool for assisting clinical decision-making in neurosurgery. A literature review of all full publications in English biomedical journals (1993-2013) was undertaken. The strategy included a combination of key words 'artificial neural networks', 'prognostic', 'brain', 'tumor tracking', 'head', 'tumor', 'spine', 'classification' and 'back pain' in the title and abstract of the manuscripts using the PubMed search engine. The major findings are summarized, with a focus on the application of ANNs for diagnostic and prognostic purposes. Finally, the future of ANNs in neurosurgery is explored. A total of 1093 citations were identified and screened. In all, 57 citations were found to be relevant. Of these, 50 articles were eligible for inclusion in this review. The synthesis of the data showed several applications of ANN in neurosurgery, including: (1) diagnosis and assessment of disease progression in low back pain, brain tumours and primary epilepsy; (2) enhancing clinically relevant information extraction from radiographic images, intracranial pressure processing, low back pain and real-time tumour tracking; (3) outcome prediction in epilepsy, brain metastases, lumbar spinal stenosis, lumbar disc herniation, childhood hydrocephalus, trauma mortality, and the occurrence of symptomatic cerebral vasospasm in patients with aneurysmal subarachnoid haemorrhage; (4) the use in the biomechanical assessments of spinal disease. ANNs can be effectively employed for diagnosis, prognosis and outcome prediction in neurosurgery.

  4. Multi-bioindicators to assess soil microbial activity in the context of an artificial groundwater recharge with treated wastewater: a large-scale pilot experiment.

    Science.gov (United States)

    Michel, Caroline; Joulian, Catherine; Ollivier, Patrick; Nyteij, Audrey; Cote, Rémi; Surdyk, Nicolas; Hellal, Jennifer; Casanova, Joel; Besnard, Katia; Rampnoux, Nicolas; Garrido, Francis

    2014-06-28

    In the context of artificial groundwater recharge, a reactive soil column at pilot-scale (4.5 m depth and 3 m in diameter) fed by treated wastewater was designed to evaluate soil filtration ability. Here, as a part of this project, the impact of treated wastewater filtration on soil bacterial communities and the soil's biological ability for wastewater treatment as well as the relevance of the use of multi-bioindicators were studied as a function of depth and time. Biomass; bacterial 16S rRNA gene diversity fingerprints; potential nitrifying, denitrifying, and sulfate-reducing activities; and functional gene (amo, nir, nar, and dsr) detection were analyzed to highlight the real and potential microbial activity and diversity within the soil column. These bioindicators show that topsoil (0 to 20 cm depth) was the more active and the more impacted by treated wastewater filtration. Nitrification was the main activity in the pilot. No sulfate-reducing activity or dsr genes were detected during the first 6 months of wastewater application. Denitrification was also absent, but genes of denitrifying bacteria were detected, suggesting that the denitrifying process may occur rapidly if adequate chemical conditions are favored within the soil column. Results also underline that a dry period (20 days without any wastewater supply) significantly impacted soil bacterial diversity, leading to a decrease of enzyme activities and biomass. Finally, our work shows that treated wastewater filtration leads to a modification of the bacterial genetic and functional structures in topsoil.

  5. DSC Study of Collagen in Disc Disease

    OpenAIRE

    S. Skrzyński; Sionkowska, A.; Marciniak, A.

    2009-01-01

    Differential scanning calorimetry (DSC) has been used to estimate the effect of disc disease on the collagen helix-coil transition and morphology for tissue extracted from patients during surgical operation. Forty discs were obtained from patients with degenerative disc disease undergoing surgery for low back pain. The patients were in the age between 20 and 70 years old. The specimens were kept wet during DSC experiment. The data allow the comparison between thermal stability of collagen ti...

  6. Biomechanical study of intervertebral disc degeneration

    OpenAIRE

    González Guitiérrez, Ramiro Arturo

    2012-01-01

    Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend and torsion loads, statically or dynamically, with load magnitudes corresponding to the physiological range. However, traditional testing does...

  7. The Roles of Discs for Planetary Systems

    CERN Document Server

    Yeh, L C; Yeh, Li-Chin; Jiang, Ing-Guey

    2007-01-01

    It is known that the discs are detected for some of the extra-solar planetary systems. It is also likely that there was a disc mixing with planets and small bodies while our Solar System was forming. From our recent results, we conclude that the discs play two roles: the gravity makes planetary systems more chaotic and the drag makes planetary systems more resonant.

  8. DISC1 genetics, biology and psychiatric illness

    OpenAIRE

    2013-01-01

    Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects u...

  9. DSC Study of Collagen in Disc Disease

    Directory of Open Access Journals (Sweden)

    S. Skrzyński

    2009-01-01

    Full Text Available Differential scanning calorimetry (DSC has been used to estimate the effect of disc disease on the collagen helix-coil transition and morphology for tissue extracted from patients during surgical operation. Forty discs were obtained from patients with degenerative disc disease undergoing surgery for low back pain. The patients were in the age between 20 and 70 years old. The specimens were kept wet during DSC experiment. The data allow the comparison between thermal stability of collagen tissue from healthy patients and from patients suffering from disc disease. In the paper the comparison between thermal helix-coil transition for collagen fibers from patients suffering from disc disease and collagen fibers from healthy organisms has been discussed. The heating rate has an influence on the position on denaturation temperatures of collagen in disc tissues. Higher helix-coil transition temperature of collagen in degenerated disc suggests that additional intermolecular cross linking of collagen fibers occurs. Denaturation temperatures of collagen in degenerated male disc possess smaller values than in female ones. Disc disease induces changes in collagen structure and leads to formation of additional crosslinks between collagen fibers.

  10. The quiescent phase of galactic disc growth

    Science.gov (United States)

    Aumer, Michael; Binney, James; Schönrich, Ralph

    2016-07-01

    We perform a series of controlled N-body simulations of growing disc galaxies within non-growing, live dark matter haloes of varying mass and concentration. Our initial conditions include either a low-mass disc or a compact bulge. New stellar particles are continuously added on near-circular orbits to the existing disc, so spiral structure is continuously excited. To study the effect of combined spiral and giant molecular cloud (GMC) heating on the discs, we introduce massive, short-lived particles that sample a GMC mass function. An isothermal gas component is introduced for a subset of the models. We perform a resolution study and vary parameters governing the GMC population, the histories of star formation and radial scale growth. Models with GMCs and standard values for the disc mass and halo density provide the right level of self-gravity to explain the age-velocity dispersion relation of the solar neighbourhood (Snhd). GMC heating generates remarkably exponential vertical profiles with scaleheights that are radially constant and agree with observations of galactic thin discs. GMCs are also capable of significantly delaying bar formation. The amount of spiral-induced radial migration agrees with what is required for the metallicity distribution of the Snhd. However, in our standard models, the outward-migrating populations are not hot enough vertically to create thick discs. Thick discs can form in models with high baryon fractions, but the corresponding bars are too long, the young stellar populations too hot and the discs flare considerably.

  11. Accretion Discs Show Their True Colours

    Science.gov (United States)

    2008-07-01

    Quasars are the brilliant cores of remote galaxies, at the hearts of which lie supermassive black holes that can generate enough power to outshine the Sun a trillion times. These mighty power sources are fuelled by interstellar gas, thought to be sucked into the hole from a surrounding 'accretion disc'. A paper in this week's issue of the journal Nature, partly based on observations collected with ESO's Very Large Telescope, verifies a long-standing prediction about the intensely luminous radiation emitted by these accretion discs. Uncovering the disc ESO PR Photo 21/08 Uncovering the inner disc "Astronomers were puzzled by the fact that the best models of these discs couldn't quite be reconciled with some of the observations, in particular, with the fact that these discs did not appear as blue as they should be," explains lead-author Makoto Kishimoto. Such a discrepancy could be the signal that there was something very wrong with the models. With his colleagues, he investigated this discrepancy by studying the polarised light from six quasars. This enabled them to demonstrate that the disc spectrum is as blue as predicted. "The crucial observational difficulty here has been that the disc is surrounded by a much larger torus containing hot dust, whose light partly outshines that of the disc," says Kishimoto. "Because the light coming from the disc is scattered in the disc vicinity and thus polarised, by observing only polarised light from the quasars, one can uncover the buried light from the disc." In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disc in infrared light. The observations were done with the FORS and ISAAC instruments on one of the 8.2-m Unit Telescopes of ESO's Very Large Telescope, located in the Atacama

  12. Manipulation of zebrafish’s orientation using artificial cilia in a microchannel with actively adaptive wall design

    Science.gov (United States)

    Mani, Karthick; Chang Chien, Tsung-Chun; Panigrahi, Bivas; Chen, Chia-Yuan

    2016-11-01

    The zebrafish is a powerful genetic model organism especially in the biomedical chapter for new drug discovery and development. The genetic toolbox which this vertebrate possesses opens a new window to investigate the etiology of human diseases with a high degree genetic similarity. Still, the requirements of laborious and time-consuming of contemporary zebrafish processing assays limit the procedure in carrying out such genetic screen at high throughput. Here, a zebrafish control scheme was initiated which includes the design and validation of a microfluidic platform to significantly increase the throughput and performance of zebrafish larvae manipulation using the concept of artificial cilia actuation. A moving wall design was integrated into this microfluidic platform first time in literature to accommodate zebrafish inside the microchannel from 1 day post-fertilization (dpf) to 6 dpf and can be further extended to 9 dpf for axial orientation control in a rotational range between 0 to 25 degrees at the minimum step of 2-degree increment in a stepwise manner. This moving wall feature was performed through the deflection of shape memory alloy wire embedded inside the microchannel controlled by the electrical waveforms with high accuracy.

  13. Evolution of linear warps in accretion discs and applications to protoplanetary discs in binaries

    CERN Document Server

    Foucart, Francois

    2014-01-01

    The existence of warped accretion discs is expected in a wide variety of astrophysical systems, including circumstellar discs in binaries and discs around binary protostars. A common feature of these discs is that they are perturbed by a misaligned external potential. In this paper, we study the long-term evolution of the disc warp and precession in the case of thick discs (with the dimensionless thickness $H/r$ larger than the viscosity parameter $\\alpha$) in which bending waves can propagate. For small warps, such discs undergo approximately rigid-body precession with a coherent global frequency. We derive the analytical expressions for the warp/twist profiles of the disc and the alignment timescale for a variety of disc models/parameters. Applying our results to circumbinary discs, we find that these discs align with the orbital plane of the binary on a timescale comparable to the global precession time of the disc, and typically much smaller than its viscous timescale. The development of parametric instab...

  14. Circumplanetary discs around young giant planets: a comparison between core-accretion and disc instability

    Science.gov (United States)

    Szulágyi, J.; Mayer, L.; Quinn, T.

    2017-01-01

    Circumplanetary discs can be found around forming giant planets, regardless of whether core accretion or gravitational instability built the planet. We carried out state-of-the-art hydrodynamical simulations of the circumplanetary discs for both formation scenarios, using as similar initial conditions as possible to unveil possible intrinsic differences in the circumplanetary disc mass and temperature between the two formation mechanisms. We found that the circumplanetary discs' mass linearly scales with the circumstellar disc mass. Therefore, in an equally massive protoplanetary disc, the circumplanetary discs formed in the disc instability model can be only a factor of 8 more massive than their core-accretion counterparts. On the other hand, the bulk circumplanetary disc temperature differs by more than an order of magnitude between the two cases. The subdiscs around planets formed by gravitational instability have a characteristic temperature below 100 K, while the core-accretion circumplanetary discs are hot, with temperatures even greater than 1000 K when embedded in massive, optically thick protoplanetary discs. We explain how this difference can be understood as the natural result of the different formation mechanisms. We argue that the different temperatures should persist up to the point when a full-fledged gas giant forms via disc instability; hence, our result provides a convenient criterion for observations to distinguish between the two main formation scenarios by measuring the bulk temperature in the planet vicinity.

  15. [Standardized terminology for disc disease].

    Science.gov (United States)

    Sánchez Pérez, M; Gil Sierra, A; Sánchez Martín, A; Gallego Gómez, P; Pereira Boo, D

    2012-01-01

    This article reviews the terminology used to describe morphological alterations in the intervertebral discs. Radiologists must be able to communicate information about the type, location, and severity of these alterations to medical and surgical clinicians. It is crucial to use simple, standard, and unified terminology to ensure comprehension not only among radiologists but also with professionals from the different specialties for whom the radiology reports are written (fundamentally traumatologists and neurosurgeons). This terminology will help ensure a more accurate diagnosis and better patient management.

  16. On the survival of zombie vortices in protoplanetary discs

    Science.gov (United States)

    Lesur, Geoffroy R. J.; Latter, Henrik

    2016-11-01

    Recently it has been proposed that the zombie vortex instability (ZVI) could precipitate hydrodynamical activity and angular momentum transport in unmagnetized regions of protoplanetary discs, also known as `dead zones'. In this Letter we scrutinize, with high-resolution 3D spectral simulations, the onset and survival of this instability in the presence of viscous and thermal physics. First, we find that the ZVI is strongly dependent on the nature of the viscous operator. Although the ZVI is easily obtained with hyperdiffusion, it is difficult to sustain with physical (second order) diffusion operators up to Reynolds numbers as high as 107. This sensitivity is probably due to the ZVI's reliance on critical layers, whose characteristic length-scale, structure, and dynamics are controlled by viscous diffusion. Second, we observe that the ZVI is sensitive to radiative processes, and indeed only operates when the Peclet number is greater than a critical value ˜104, or when the cooling time is longer than ˜10Ω-1. As a consequence, the ZVI struggles to appear at R ≳ 0.3 au in standard 0.01 M⊙ T Tauri disc models, though younger more massive discs provide a more hospitable environment. Together these results question the prevalence of the ZVI in protoplanetary discs.

  17. The case for cases B and C: intrinsic hydrogen line ratios of the broad-line region of active galactic nuclei, reddenings, and accretion disc sizes

    CERN Document Server

    Gaskell, C Martin

    2016-01-01

    Low-redshift active galactic nuclei (AGNs) with extremely blue optical spectral indices are shown to have a mean, velocity-averaged, broad-line H$\\alpha$/H$\\beta$ ratio of $\\thickapprox 2.72 \\pm 0.04$, consistent with the Baker-Menzel Case B value. Comparison of a wide range of properties of the very bluest AGNs with those of a luminosity-matched subset of the Dong et al. blue AGN sample indicates that the only difference is the internal reddening. Ultraviolet fluxes are brighter for the bluest AGNs by an amount consistent with the flat AGN reddening curve of Gaskell et al. (2004). The lack of a significant difference in the GALEX (FUV--NUV) colour index strongly rules out a steep SMC-like reddening curve and also argues against an intrinsically harder spectrum. For very blue AGNs the Ly$\\alpha$/H$\\beta$ ratio is also consistent with being the Case B value. The Case B ratios provide strong support for the self-shielded broad-line model of Gaskell, Klimek & Nazarova. It is proposed that the greatly enhance...

  18. Meta-Learning Evolutionary Artificial Neural Networks

    OpenAIRE

    Abraham, Ajith

    2004-01-01

    In this paper, we present MLEANN (Meta-Learning Evolutionary Artificial Neural Network), an automatic computational framework for the adaptive optimization of artificial neural networks wherein the neural network architecture, activation function, connection weights; learning algorithm and its parameters are adapted according to the problem. We explored the performance of MLEANN and conventionally designed artificial neural networks for function approximation problems. To evaluate the compara...

  19. Minimum weight design of inhomogeneous rotating discs

    Energy Technology Data Exchange (ETDEWEB)

    Jahed, Hamid [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of); Farshi, Behrooz [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of)]. E-mail: farshi@iust.ac.ir; Bidabadi, Jalal [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of)

    2005-01-01

    There are numerous applications for gas turbine discs in the aerospace industry such as in turbojet engines. These discs normally work under high temperatures while subjected to high angular velocities. Minimizing the weight of such items in aerospace applications results in benefits such as low dead weights and lower costs. High speed of rotation causes large centrifugal forces in a disc and simultaneous application of high temperatures reduces disc material strength. Thus, the latter effects tend to increase deformations of the disc under the applied loads. In order to obtain a reliable disc analysis and arrive at the corresponding correct stress distribution, solutions should consider changes in material properties due to the temperature field throughout the disc. To achieve this goal, an inhomogeneous disc model with variable thickness is considered. Using the variable material properties method, stresses are obtained for the disc under rotation and a steady temperature field. In this paper this is done by modelling the rotating disc as a series of rings of different but constant properties. The optimum disc profile is arrived at by sequentially proportioning the thicknesses of each ring to satisfy the stress requirements. This method vis-a-vis a mathematical programming procedure for optimization shows several advantages. Firstly, it is simple iterative proportioning in each design cycle not requiring involved mathematical operations. Secondly, due to its simplicity it alleviates the necessity of certain simplifications that are common in so-called rigorous mathematical procedures. The results obtained, compared to those published in the literature show agreement and superiority. A further advantage of the proposed method is the independence of the end results from the initially assumed point in the iterative design routine, unlike most methods published so far.

  20. Determination of the activity concentration levels of the artificial radionuclide137Cs in soil samples collected from Qatar using high-resolution gamma-ray spectrometry

    Science.gov (United States)

    Al-Sulaiti, Huda; Nasir, Tabassum; Al Mugren, K. S.; Alkhomashi, N.; Al-Dahan, N.; Al-Dosari, M.; Bradley, D. A.; Bukhari, S.; Regan, P. H.; Santawamaitre, T.; Malain, D.; Habib, A.; Al-Dosari, Hanan; Daar, Eman

    2016-09-01

    The goal of this study was to establish the first baseline measurements for radioactivity concentration of the artificial radionuclide 137Cs in soil samples collected from the Qatarian peninsula. The work focused on the determination of the activity concentrations levels of man-made radiation in 129 soil samples collected across the landscape of the State of Qatar. All the samples were collected before the most recent accident in Japan, “the 2011 Fukushima Dai-ichi nuclear power plant accident”. The activity concentrations have been measured via high-resolution gamma-ray spectrometry using a hyper-pure germanium detector situated in a low-background environment with a copper inner-plated passive lead shield. A radiological map showing the activity concentrations of 137Cs is presented in this work. The concentration wasfound to range from 0.21 to 15.41 Bq/kg. The highest activity concentration of 137Cs was observed in sample no. 26 in North of Qatar. The mean value was found to be around 2.15 ± 0.27 Bq/kg. These values lie within the expected range relative to the countries in the region. It is expected that this contamination is mainly due to the Chernobyl accident on 26 April 1986, but this conclusion cannot be confirmed because of the lack of data before this accident.

  1. Intraosseous disc prolapse: A diagnostic puzzle

    Directory of Open Access Journals (Sweden)

    Parasnis Rajesh

    2006-01-01

    Full Text Available Background : Schmorl′s node or intraosseous disc prolapse is herniation of the nucleus pulposus material through the vertebral end plates. Presence of Schmorl′s nodes as end plate lesions following trauma, tumours and osteoporosis further complicates diagnosis. The present study was done to understand diagnosis and approach to management of symptomatic Schmorl′s nodes. Methods : During a period of three years we came across 14 patients who presented with severe back pain. Conventional radiographs, CT Scans and MRI showed the presence of end plate lesions with varied radiological appearance. The first group, comprising of seven patients had lytic lesions without any sclerosis on only one side of the intervertebral disc as seen on the CT scan. The second group comprising of five patients had sclerotic lesions with new bone formation associated with disc space reduction. The two patients in the third group showed a combined lytic and sclerotic lesion without any soft tissue changes. MRI of eleven patients revealed hypointense lesion on T 1 and T 2 weighted images with surrounding zone of hyper intensity on T 2 weighted images. The remaining three patients, did not have this hyper intense zone on T 2 weighted images . In five patients multiple Schmorl′s nodes were observed. Diagnosis of symptomatic Schmorl′s nodes was mainly done by exclusion. All patients were given rest and anti-inflammatory drugs followed by exercises. Results : The first two groups of patients responded to the treatment and had complete relief of symptoms but both the patients in third group had persistent symptoms. MRI repeated after eight weeks showed an enhancing lesion with prevertebral soft tissue. A transpedicular core biopsy proved the lesion to be tuberculosis in one patient. Anti Koch′s therapy was promptly started and follow up study showed resolution of the lesions. At the end of the study period all the patients were asymptomatic and returned to their

  2. On the possibilities of mass loss from an advective accretion disc around stationary black holes

    CERN Document Server

    Das, Santabrata; Nandi, Anuj; Sarkar, Biplob

    2014-01-01

    We study the coupled disc-jet system around the black hole where the outflow solutions are obtained in terms of the inflow parameters. We observe that an advective accretion disc can eject outflows/jets for wide range of viscosity parameter. However, such possibility is reduced if the cooling is active as the energy dissipative process inside the disc. For mass outflow, we obtain the parameter space spanned by the inflow angular momentum and the viscosity in terms of cooling and quantify the limits of viscosity parameter.

  3. Post-Main Sequence Evolution of Debris Discs

    OpenAIRE

    Bonsor, Amy; Wyatt, Mark

    2010-01-01

    The population of debris discs on the main sequence is well constrained, however very little is known about debris discs around evolved stars. In this work we provide a theoretical framework that considers the effects of stellar evolution on debris discs; firstly considering the evolution of an individual disc from the main sequence through to the white dwarf phase, then extending this to the known population of debris discs around main sequence A stars. It is found that discs around evolved ...

  4. Genetic association studies in lumbar disc degeneration

    DEFF Research Database (Denmark)

    Eskola, Pasi J; Lemmelä, Susanna; Kjaer, Per;

    2012-01-01

    Low back pain is associated with lumbar disc degeneration, which is mainly due to genetic predisposition. The objective of this study was to perform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magnetic resonance imaging (MRI) in humans....

  5. The maximum rotation of a galactic disc

    NARCIS (Netherlands)

    Bottema, R

    1997-01-01

    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously

  6. The inner cavity of the circumnuclear disc

    Science.gov (United States)

    Blank, M.; Morris, M. R.; Frank, A.; Carroll-Nellenback, J. J.; Duschl, W. J.

    2016-06-01

    The circumnuclear disc (CND) orbiting the Galaxy's central black hole is a reservoir of material that can ultimately provide energy through accretion, or form stars in the presence of the black hole, as evidenced by the stellar cluster that is presently located at the CND's centre. In this paper, we report the results of a computational study of the dynamics of the CND. The results lead us to question two paradigms that are prevalent in previous research on the Galactic Centre. The first is that the disc's inner cavity is maintained by the interaction of the central stellar cluster's strong winds with the disc's inner rim, and secondly, that the presence of unstable clumps in the disc implies that the CND is a transient feature. Our simulations show that, in the absence of a magnetic field, the interaction of the wind with the inner disc rim actually leads to a filling of the inner cavity within a few orbital time-scales, contrary to previous expectations. However, including the effects of magnetic fields stabilizes the inner disc rim against rapid inward migration. Furthermore, this interaction causes instabilities that continuously create clumps that are individually unstable against tidal shearing. Thus the occurrence of such unstable clumps does not necessarily mean that the disc is itself a transient phenomenon. The next steps in this investigation are to explore the effect of the magnetorotational instability on the disc evolution and to test whether the results presented here persist for longer time-scales than those considered here.

  7. Hygroviscoelasticity of the Human Intervertebral Disc.

    Science.gov (United States)

    1980-07-01

    hernia - tion with age depends on the biochemical changes that occur in the material of the disc during its maturation process. However, a careful machanics...EFFORT One of the recurring pieces of information required in disc response is the intra- discal pressure when the spine is loaded axially. This

  8. Feature Based Control of Compact Disc Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh

    Two servo control loops are used to keep the Optical Pick-up Unit focused and radially on the information track of the Compact Disc. These control servos have problems handling surface faults on the Compact Disc. In this Ph.D thesis a method is proposed to improve the handling of these surface...

  9. Hydromagnetic Flow between Two Rotating Coaxial Discs

    Directory of Open Access Journals (Sweden)

    Abdul Aleem Khan

    1970-01-01

    Full Text Available This paper relates to the steady flow of an electrically incompressible viscous fluid between two parallel coaxial rotating discs with a transverse magnetic field when the discs are rotating in the same direction with the same velocity and there is a source at the centre.

  10. Artificial neural network modelling of the antioxidant activity and phenolic compounds of bananas submitted to different drying treatments.

    Science.gov (United States)

    Guiné, Raquel P F; Barroca, Maria João; Gonçalves, Fernando J; Alves, Mariana; Oliveira, Solange; Mendes, Mateus

    2015-02-01

    Bananas (cv. Musa nana and Musa cavendishii) fresh and dried by hot air at 50 and 70°C and lyophilisation were analysed for phenolic contents and antioxidant activity. All samples were subject to six extractions (three with methanol followed by three with acetone/water solution). The experimental data served to train a neural network adequate to describe the experimental observations for both output variables studied: total phenols and antioxidant activity. The results show that both bananas are similar and air drying decreased total phenols and antioxidant activity for both temperatures, whereas lyophilisation decreased the phenolic content in a lesser extent. Neural network experiments showed that antioxidant activity and phenolic compounds can be predicted accurately from the input variables: banana variety, dryness state and type and order of extract. Drying state and extract order were found to have larger impact in the values of antioxidant activity and phenolic compounds.

  11. Twisted accretion discs: Pt. 4. Alignment in polytropic discs and low. cap alpha. limit

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S.

    1988-07-01

    Twisted thin accretion discs are of interest in explaining long-term periodicities in X-ray binaries, the eclipse in Epsilon Aurigae, and perhaps precessing radio jets and possible warped molecular outflows in star-forming regions. Earlier results used isothermal discs to determine the alignment radius, Rsub(a). Now we see how polytropic discs effect earlier results for discs around compact objects and around close binaries. We find that Rsub(a) for polytropic discs can be up to an order of magnitude larger, depending on the polytropic index, the viscosity parameter and the precession mechanism. There is little change in the earlier conclusion that the case for alignment in Her X-1 is marginal, while there is substantial alignment in epsilon Aur. A lower limit is put on ..cap alpha.. for isothermal discs, which is expected to hold for polytropic discs as well. A bound is put on the energy of the perturbed flows.

  12. On the reliability of protostellar disc mass measurements and the existence of fragmenting discs

    CERN Document Server

    Dunham, Michael M; Arce, Héctor G

    2014-01-01

    We couple non-magnetic, hydrodynamical simulations of collapsing protostellar cores with radiative transfer evolutionary models to generate synthetic observations. We then use these synthetic observations to investigate the extent to which a simple method for measuring protostellar disc masses used in the literature recovers the intrinsic masses of the discs formed in the simulations. We evaluate the effects of contamination from the surrounding core, partially resolving out the disc, optical depth, fixed assumed dust temperatures, inclination, and the dust opacity law. We show that the combination of these effects can lead to disc mass underestimates by up to factors of 2-3 at millimeter wavelengths and up to an order of magnitude or larger at submillimeter wavelengths. The optically thin portions of protostellar discs are generally cooler in the Class I stage than the Class 0 stage since Class I discs are typically larger and more optically thick, and thus more shielded. The observed disc mass distribution ...

  13. Magnetic resonance imaging of intervertebral disc degeneration

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Hiroshi; Noguchi, Masao (Kitakyushu City Yahata Hospital, Fukuoka (Japan)); Kira, Hideaki; Fujiki, Hiroshi; Shimokawa, Isao; Hinoue, Kaichi

    1993-02-01

    The aim of this study was to correlate the degree of lumbar intervertebral disc degeneration with findings of magnetic resonance imaging (MRI). Seventeen autopsied (from 7 patients) and 21 surgical (from 20 patients) intervertebral discs were used as specimens for histopathological examination. In addition, 21 intervertebral discs were examined on T2-weighted images. Histopathological findings from both autopsied and surgical specimens were well correlated with MRI findings. In particular, T2-weighted images reflected increased collagen fibers and rupture within the fibrous ring accurately. However, when severely degenerated intervertebral discs and hernia protruding the posterior longitudinal ligament existed, histological findings were not concordant well with T2-weighted images. Morphological appearances of autopsy specimens, divided into four on T2-weighted images, were well consistent with histological degeneration. This morphological classification, as shown on T2-weighted images, could also be used in the evaluation of intervertebral disc degeneration. (N.K.).

  14. Strongly magnetized accretion discs require poloidal flux

    CERN Document Server

    Salvesen, Greg; Simon, Jacob B; Begelman, Mitchell C

    2016-01-01

    Motivated by indirect observational evidence for strongly magnetized accretion discs around black holes, and the novel theoretical properties of such solutions, we investigate how a strong magnetization state can develop and persist. To this end, we perform local simulations of accretion discs with an initially purely toroidal magnetic field of equipartition strength. We demonstrate that discs with zero net vertical magnetic flux and realistic boundary conditions cannot sustain a strong toroidal field. However, a magnetic pressure-dominated disc can form from an initial configuration with a sufficient amount of net vertical flux and realistic boundary conditions. Our results suggest that poloidal flux is a necessary prerequisite for the sustainability of strongly magnetized accretion discs.

  15. Lumbar Epidural Varix Mimicking Disc Herniation.

    Science.gov (United States)

    Bursalı, Adem; Akyoldas, Goktug; Guvenal, Ahmet Burak; Yaman, Onur

    2016-07-01

    Lumbar radiculopathy is generally caused by such well-recognized entity as lumbar disc herniation in neurosurgical practice; however rare pathologies such as thrombosed epidural varix may mimic them by causing radicular symptoms. In this case report, we present a 26-year-old man with the complaint of back and right leg pain who was operated for right L4-5 disc herniation. The lesion interpreted as an extruded disc herniation preoperatively was found to be a thrombosed epidural varix compressing the nerve root preoperatively. The nerve root was decompressed by shrinking the lesion with bipolar thermocoagulation and excision. The patient's complaints disappeared in the postoperative period. Thrombosed lumbar epidural varices may mimic lumbar disc herniations both radiologically and clinically. Therefore, must be kept in mind in the differential diagnosis of lumbar disc herniations. Microsurgical techniques are mandatory for the treatment of these pathologies and decompression with thermocoagulation and excision is an efficient method.

  16. Angular momentum transport in protostellar discs

    CERN Document Server

    Salmeron, Roberto Aureliano; Wardle, M; Salmeron, Raquel; Konigl, Arieh; Wardle, Mark

    2006-01-01

    Angular momentum transport in protostellar discs can take place either radially, through turbulence induced by the magnetorotational instability (MRI), or vertically, through the torque exerted by a large-scale magnetic field that threads the disc. Using semi-analytic and numerical results, we construct a model of steady-state discs that includes vertical transport by a centrifugally driven wind as well as MRI-induced turbulence. We present approximate criteria for the occurrence of either one of these mechanisms in an ambipolar diffusion-dominated disc. We derive ``strong field'' solutions in which the angular momentum transport is purely vertical and ``weak field'' solutions that are the stratified-disc analogues of the previously studied MRI channel modes; the latter are transformed into accretion solutions with predominantly radial angular-momentum transport when we implement a turbulent-stress prescription based on published results of numerical simulations. We also analyze ``intermediate field strength'...

  17. Lumbar disc cyst with contralateral radiculopathy

    Directory of Open Access Journals (Sweden)

    Kishore Tourani

    2012-08-01

    Full Text Available Disc cysts are uncommon intraspinal cystic lesions located in the ventrolateral epidural space. They communicate with the nucleus pulposus of the intervertebral disc and cause symptoms by radicular compression. We report a unique case of lumbar disc cyst that was associated with disc herniation and contralateral radiculopathy. A 22 year old male presented with one month history of back-ache radiating to the left leg. Magnetic Resonance Imaging (MRI showed L3-L4 disc herniation with annular tear and cystic lesion in the extradural space anterior to the thecal sac on right side, which increased in size over a period of 3 weeks. L3 laminectomy and bilateral discectomy and cyst excision was done with partial improvement of patients symptoms.

  18. About detection of precessing circumpulsar discs

    Science.gov (United States)

    Grimani, Catia

    2016-08-01

    Detections of circumpulsar discs and planetary systems through electromagnetic observations appear quite rare. In the case of PSR 1931+24 and B0656+14, the hypothesis of a precessing disc penetrating the pulsar light cylinder is found consistent with radio and gamma observations from these stars. Disc self-occultation and precession may affect electromagnetic measurements. We investigate here under which conditions gravitational waves generated by circumpulsar disc precession may be detected by the proposed second-generation space interferometers DECI-hertz Interferometer Gravitational Wave Observatory and Big Bang Observer. The characteristics of circumpulsar detectable precessing discs are estimated as a function of distance from the Solar system. Speculations on detection rates are presented.

  19. The formation of planets by disc fragmentation

    Directory of Open Access Journals (Sweden)

    Stamatellos Dimitris

    2013-04-01

    Full Text Available I discuss the role that disc fragmentation plays in the formation of gas giant and terrestrial planets, and how this relates to the formation of brown dwarfs and low-mass stars, and ultimately to the process of star formation. Protostellar discs may fragment, if they are massive enough and can cool fast enough, but most of the objects that form by fragmentation are brown dwarfs. It may be possible that planets also form, if the mass growth of a proto-fragment is stopped (e.g. if this fragment is ejected from the disc, or suppressed and even reversed (e.g by tidal stripping. I will discuss if it is possible to distinguish whether a planet has formed by disc fragmentation or core accretion, and mention of a few examples of observed exoplanets that are suggestive of formation by disc fragmentation.

  20. Strongly magnetized accretion discs require poloidal flux

    Science.gov (United States)

    Salvesen, Greg; Armitage, Philip J.; Simon, Jacob B.; Begelman, Mitchell C.

    2016-08-01

    Motivated by indirect observational evidence for strongly magnetized accretion discs around black holes, and the novel theoretical properties of such solutions, we investigate how a strong magnetization state can develop and persist. To this end, we perform local simulations of accretion discs with an initially purely toroidal magnetic field of equipartition strength. We demonstrate that discs with zero net vertical magnetic flux and realistic boundary conditions cannot sustain a strong toroidal field. However, a magnetic pressure-dominated disc can form from an initial configuration with a sufficient amount of net vertical flux and realistic boundary conditions. Our results suggest that poloidal flux is a necessary prerequisite for the sustainability of strongly magnetized accretion discs.

  1. During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.

    Science.gov (United States)

    Katsuyama, Tomonori; Comoglio, Federico; Seimiya, Makiko; Cabuy, Erik; Paro, Renato

    2015-05-05

    Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving local cell proliferation at the wound site. After disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation, and repatterning of the tissue. However, the interplay of signaling cascades driving these early reprogramming steps is not well-understood. Here, we profiled the transcriptome of regenerating cells in the early phase within 24 h after wounding. We found that JAK/STAT signaling becomes activated at the wound site and promotes regenerative cell proliferation in cooperation with Wingless (Wg) signaling. In addition, we showed that the expression of Drosophila insulin-like peptide 8 (dilp8), which encodes a paracrine peptide to delay the onset of pupariation, is controlled by JAK/STAT signaling in early regenerating discs. Our findings suggest that JAK/STAT signaling plays a pivotal role in coordinating regenerative disc growth with organismal developmental timing.

  2. Kinematics and Excitation of the Molecular Hydrogen Accretion Disc in NGC 1275

    CERN Document Server

    Scharwaechter, J; Dopita, M A; Beck, T L

    2012-01-01

    We report the results of high spatial and spectral resolution integral-field spectroscopy of the central ~3 x 3 arcsec^2 of the active galaxy NGC 1275 (Perseus A), based on observations with the Near-infrared Integral Field Spectrograph (NIFS) and the ALTAIR adaptive-optics system on the Gemini North telescope. The circum-nuclear disc in the inner R~50 pc of NGC 1275 is seen in both the H2 and [FeII] lines. The disc is interpreted as the outer part of a collisionally-excited turbulent accretion disc. The kinematic major axis of the disc at a position angle of 68 deg is oriented perpendicular to the radio jet. A streamer-like feature to the south-west of the disc, detected in H2 but not in [FeII], is discussed as one of possibly several molecular streamers, presumably falling into the nuclear region. Indications of an ionization structure within the disc are deduced from the HeI and Br gamma emission lines, which may partially originate from the inner portions of the accretion disc. The kinematics of these two...

  3. Properties of HI discs in the Auriga cosmological simulations

    Science.gov (United States)

    Marinacci, Federico; Grand, Robert J. J.; Pakmor, Rüdiger; Springel, Volker; Gómez, Facundo A.; Frenk, Carlos S.; White, Simon D. M.

    2017-01-01

    We analyse the properties of the HI gas distribution in the Auriga project, a set of magnetohydrodynamic cosmological simulations performed with the moving-mesh code AREPO and a physics model for galaxy formation that succeeds in forming realistic late-type galaxies in the 30 Milky Way-sized haloes simulated in this project. We use a simple approach to estimate the neutral hydrogen fraction in our simulation set, which treats low-density and star-forming gas separately, and we explore two different prescriptions to subtract the contribution of molecular hydrogen from the total HI content. The HI gas in the vast majority of the systems forms extended discs although more disturbed morphologies are present. Notwithstanding the general good agreement with observed HI properties - such as radial profiles and the mass-diameter relation - the Auriga galaxies are systematically larger and more gas-rich than typical nearby galaxies. Interestingly, the amount of HI gas outside the disc plane correlates with the star formation rate, consistent with a picture where most of this extra-planar HI gas originates from a fountain-like flow. Our findings are robust with respect to the different assumptions adopted for computing the molecular hydrogen fraction and do not vary significantly over a wide range of numerical resolution. The HI modelling introduced in this paper can be used in future work to build artificial interferometric HI data cubes, allowing an even closer comparison of the gas dynamics in simulated galaxies with observations.

  4. Spine imaging after lumbar disc replacement: pitfalls and current recommendations

    Directory of Open Access Journals (Sweden)

    Sandén Bengt

    2009-07-01

    Full Text Available Abstract Background Most lumbar artificial discs are still composed of stainless steel alloys, which prevents adequate postoperative diagnostic imaging of the operated region when using magnetic resonance imaging (MRI. Thus patients with postoperative radicular symptoms or claudication after stainless steel implants often require alternative diagnostic procedures. Methods Possible complications of lumbar total disc replacement (TDR are reviewed from the available literature and imaging recommendations given with regard to implant type. Two illustrative cases are presented in figures. Results Access-related complications, infections, implant wear, loosening or fracture, polyethylene inlay dislodgement, facet joint hypertrophy, central stenosis, and ankylosis of the operated segment can be visualised both in titanium and stainless steel implants, but require different imaging modalities due to magnetic artifacts in MRI. Conclusion Alternative radiographic procedures should be considered when evaluating patients following TDR. Postoperative complications following lumbar TDR including spinal stenosis causing radiculopathy and implant loosening can be visualised by myelography and radionucleotide techniques as an adjunct to plain film radiographs. Even in the presence of massive stainless steel TDR implants lumbar radicular stenosis and implant loosening can be visualised if myelography and radionuclide techniques are applied.

  5. Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.

    Science.gov (United States)

    Tanaka, Motomasa; Ishizuka, Koko; Nekooki-Machida, Yoko; Endo, Ryo; Takashima, Noriko; Sasaki, Hideyuki; Komi, Yusuke; Gathercole, Amy; Huston, Elaine; Ishii, Kazuhiro; Hui, Kelvin Kai-Wan; Kurosawa, Masaru; Kim, Sun-Hong; Nukina, Nobuyuki; Takimoto, Eiki; Houslay, Miles D; Sawa, Akira

    2017-04-03

    Huntington's disease (HD) is a polyglutamine (polyQ) disease caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated by polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor symptoms in HD, such as psychiatric manifestations, remain elusive. Here we have demonstrated that HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. We observed pathological cross-seeding between DISC1 and mutant HTT aggregates in the brains of HD patients as well as in a murine model that recapitulates the polyQ pathology of HD (R6/2 mice). In R6/2 mice, consequent reductions in soluble DISC1 led to dysregulation of DISC1-PDE4 complexes, aberrantly increasing the activity of PDE4. Importantly, exogenous expression of a modified DISC1, which binds to PDE4 but not mutant HTT, normalized PDE4 activity and ameliorated anhedonia in the R6/2 mice. We propose that cross-seeding of mutant HTT and DISC1 and the resultant changes in PDE4 activity may underlie the pathology of a specific subset of mental manifestations of HD, which may provide an insight into molecular signaling in mental illness in general.

  6. Flares in Gamma Ray Bursts: Disc Fragmentation and Evolution

    CERN Document Server

    Dall'Osso, Simone; Tanaka, Takamitsu L; Margutti, Raffaella

    2016-01-01

    Flaring activity following gamma-ray bursts (GRBs), observed in both long and short GRBs, signals a long-term activity of the central engine. However, its production mechanism has remained elusive. Here we develop a quantitative model of the idea proposed by Perna et al. of a disc whose outer regions fragment due to the onset of gravitational instability. The self-gravitating clumps migrate through the disc and begin to evolve viscously when tidal and shearing torques break them apart. Our model consists of two ingredients: theoretical bolometric flare lightcurves whose shape (width, skewness) is largely insensitive to the model parameters, and a spectral correction to match the bandpass of the available observations, that is calibrated using the observed spectra of the flares. This simple model reproduces, with excellent agreement, the empirical statistical properties of the flares as measured by their width-to-arrival time ratio and skewness (ratio between decay and rise time). We present model fits to the ...

  7. A direct protein kinase B-targeted anti inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris

    Directory of Open Access Journals (Sweden)

    Ju Young Yoon

    2015-01-01

    Full Text Available Background: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. Objective: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE from Cordyceps militaris and to evaluate their anti-inflammatory activities. Materials and Methods: Column chromatographic separation was performed and anti-inflammatory roles of these compounds were also examined by using NO production and protein kinase B (AKT activity assays. Results: From Cm-EE, 13 constituents, including trehalose (1, cordycepin (2, 6-hydroxyethyladenosine (3, nicotinic amide (4, butyric acid (5, β-dimorphecolic acid (6, α-dimorphecolic acid (7, palmitic acid (8, linoleic acid (9, cordycepeptide A (10, 4-(2-hydroxy-3-((9E,12E-octadeca-9,12-dienoyloxypropoxy-2-(trimethylammoniobutanoate (11, 4-(2-hydroxy-3-(palmitoyloxypropoxy-2-(trimethylammoniobutanoate (12, and linoleic acid methyl ester (13 were isolated. Of these components, compound 2 displayed a significant inhibitory effect on NO production in lipopolysaccharide (LPS-activated RAW264.7 cells. Furthermore, this compound strongly and directly suppressed the kinase activity of AKT, an essential signalling enzyme in LPS-induced NO production, by interacting with its ATP binding site. Conclusion: C. militaris could have anti-inflammatory activity mediated by cordycepin-induced suppression of AKT.

  8. Biomechanical Analysis of a Novel Prosthesis Based on the Physiological Curvature of Endplate for Cervical Disc Replacement.

    Directory of Open Access Journals (Sweden)

    Cheng-Cheng Yu

    Full Text Available Biomechanical analysis of a novel prosthesis based on the physiological curvature of endplate was performed.To compare the biomechanical differences between a novel prosthesis based on the physiological curvature of the endplate and the Prestige LP prosthesis after cervical disc replacement (CDR.Artificial disc prostheses have been widely used to preserve the physiological function of treated and adjacent motion segments in CDR, while most of those present a flat surface instead of an arcuate surface which approximately similar to anatomic structures in vivo. We first reported a well-designed artificial disc prosthesis based on the physiological curvature of the endplate.Three motion segments of 24 ovine cervical spines (C2-5 were evaluated in a robotic spine system with axial compressive loads of 50N. Testing conditions were as follows: 1 intact, 2 C3-4 CDR with artificial disc prosthesis based on the physiological curvature of the endplate, and 3 C3-4 CDR with the Prestige LP prosthesis. The range of motion (ROM and the pressures on the inferior surface of the two prostheses were recorded and analyzed.As compared to the intact state, the ROM of all three segments had no significant difference in the replacement group. Additionally, there was no significant difference in ROM between the two prostheses. The mean pressure on the novel prosthesis was significantly less than the Prestige LP prosthesis.ROM in 3 groups (intact group, CDR group with novel prosthesis and CDR group with Prestige LP showed no significant difference. The mean pressure on the inferior surface of the novel prosthesis was significantly lower than the Prestige LP prosthesis. Therefore, the novel artificial disc prosthesis is feasible and effective, and can reduce the implant-bone interface pressure on the endplate, which may be one possible reason of prosthesis subsidence.

  9. Generation of highly inclined protoplanetary discs through single stellar flybys

    CERN Document Server

    Xiang-Gruess, Meng

    2015-01-01

    We study the three-dimensional evolution of a viscous protoplanetary disc which is perturbed by a passing star on a parabolic orbit. The aim is to test whether a single stellar flyby is capable to excite significant disc inclinations which would favour the formation of so-called misaligned planets. We use smoothed particle hydrodynamics to study inclination, disc mass and angular momentum changes of the disc for passing stars with different masses. We explore different orbital configurations for the perturber's orbit to find the parameter spaces which allow significant disc inclination generation. Prograde inclined parabolic orbits are most destructive leading to significant disc mass and angular momentum loss. In the remaining disc, the final disc inclination is only below $20^\\circ$. This is due to the removal of disc particles which have experienced the strongest perturbing effects. Retrograde inclined parabolic orbits are less destructive and can generate disc inclinations up to $60^\\circ$. The final disc...

  10. Gravitoturbulence in magnetised protostellar discs

    CERN Document Server

    Riols, A

    2016-01-01

    Gravitational instability (GI) features in several aspects of protostellar disk evolution, most notably in angular momentum transport, fragmentation, and the outbursts exemplified by FU Ori and EX Lupi systems. The outer regions of protostellar discs may also be coupled to magnetic fields, which could then modify the development of GI. To understand the basic elements of their interaction, we perform local 2D ideal and resistive MHD simulations with an imposed toroidal field. In the regime of moderate plasma beta, we find that the system supports a hot gravito-turbulent state, characterised by considerable magnetic energy and stress and a surprisingly large Toomre parameter $Q~10$. This result has potential implications for disk structure, vertical thickness, ionisation, etc. Our simulations also reveal the existence of long-lived and dense `magnetic islands' or plasmoids. Lastly, we find that the presence of a magnetic field has little impact on the fragmentation criterion of the disk. Though our focus is on...

  11. Trends in Artificial Intelligence.

    Science.gov (United States)

    Hayes, Patrick

    1978-01-01

    Discusses the foundations of artificial intelligence as a science and the types of answers that may be given to the question, "What is intelligence?" The paradigms of artificial intelligence and general systems theory are compared. (Author/VT)

  12. Lumbar herniated disc: spontaneous regression

    Science.gov (United States)

    Yüksel, Kasım Zafer

    2017-01-01

    Background Low back pain is a frequent condition that results in substantial disability and causes admission of patients to neurosurgery clinics. To evaluate and present the therapeutic outcomes in lumbar disc hernia (LDH) patients treated by means of a conservative approach, consisting of bed rest and medical therapy. Methods This retrospective cohort was carried out in the neurosurgery departments of hospitals in Kahramanmaraş city and 23 patients diagnosed with LDH at the levels of L3−L4, L4−L5 or L5−S1 were enrolled. Results The average age was 38.4 ± 8.0 and the chief complaint was low back pain and sciatica radiating to one or both lower extremities. Conservative treatment was administered. Neurological examination findings, durations of treatment and intervals until symptomatic recovery were recorded. Laségue tests and neurosensory examination revealed that mild neurological deficits existed in 16 of our patients. Previously, 5 patients had received physiotherapy and 7 patients had been on medical treatment. The number of patients with LDH at the level of L3−L4, L4−L5, and L5−S1 were 1, 13, and 9, respectively. All patients reported that they had benefit from medical treatment and bed rest, and radiologic improvement was observed simultaneously on MRI scans. The average duration until symptomatic recovery and/or regression of LDH symptoms was 13.6 ± 5.4 months (range: 5−22). Conclusions It should be kept in mind that lumbar disc hernias could regress with medical treatment and rest without surgery, and there should be an awareness that these patients could recover radiologically. This condition must be taken into account during decision making for surgical intervention in LDH patients devoid of indications for emergent surgery. PMID:28119770

  13. Artificial Video for Video Analysis

    Science.gov (United States)

    Gallis, Michael R.

    2010-01-01

    This paper discusses the use of video analysis software and computer-generated animations for student activities. The use of artificial video affords the opportunity for students to study phenomena for which a real video may not be easy or even possible to procure, using analysis software with which the students are already familiar. We will…

  14. Self-assembled monolayers of Aβ peptides on Au electrodes: an artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer's disease.

    Science.gov (United States)

    Pramanik, Debajyoti; Sengupta, Kushal; Mukherjee, Soumya; Dey, Somdatta Ghosh; Dey, Abhishek

    2012-07-25

    The water-soluble hydrophilic part of human Aβ peptide has been extended to include a C-terminal cysteine residue. Utilizing the thiol functionality of this cysteine residue, self-assembled monolayers (SAM) of these peptides are formed on Au electrodes. Atomic force microscopy imaging confirms formation of small Aβ aggregates on the surface of the electrode. These aggregates bind redox active metals like Cu and cofactors like heme, both of which are proposed to generate toxic partially reduced oxygen species (PROS) and play a vital role in Alzheimer's disease. The spectroscopic and electrochemical properties of these Cu and heme bound Aβ SAM are similar to those reported for the soluble Cu and heme bound Aβ peptide. Experiments performed on these Aβ-SAM electrodes clearly demonstrate that (1) heme bound Aβ is kinetically more competent in reducing O(2) than Cu bound Aβ, (2) under physiological conditions the reduced Cu site produces twice as much PROS (measured in situ) than the reduced heme site, and (3) chelators like clioquinol remove Cu from these aggregates, while drugs like methylene blue inhibit O(2) reactivity of the heme cofactor. This artificial construct provides a very easy platform for investigating potential drugs affecting aggregation of human Aβ peptides and PROS generation by its complexes with redox active metals and cofactors.

  15. Comparison of ultrasonic with stirrer performance for removal of sunset yellow (SY) by activated carbon prepared from wood of orange tree: Artificial neural network modeling

    Science.gov (United States)

    Ghaedi, A. M.; Ghaedi, M.; Karami, P.

    2015-03-01

    The present work focused on the removal of sunset yellow (SY) dye from aqueous solution by ultrasound-assisted adsorption and stirrer by activated carbon prepared from wood of an orange tree. Also, the artificial neural network (ANN) model was used for predicting removal (%) of SY dye based on experimental data. In this study a green approach was described for the synthesis of activated carbon prepared from wood of an orange tree and usability of it for the removal of sunset yellow. This material was characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The impact of variables, including initial dye concentration (mg/L), pH, adsorbent dosage (g), sonication time (min) and temperature (°C) on SY removal were studied. Fitting the experimental equilibrium data of different isotherm models such as Langmuir, Freundlich, Temkin and Dubinin-Radushkevich models display the suitability and applicability of the Langmuir model. Analysis of experimental adsorption data by different kinetic models including pseudo-first and second order, Elovich and intraparticle diffusion models indicate the applicability of the second-order equation model. The adsorbent (0.5 g) is applicable for successful removal of SY (>98%) in short time (10 min) under ultrasound condition.

  16. Application of Artificial Neural Network (ANN in Estimation of Body Mass Index (BMI Based on the Connection Between Environmental Factors and Physical Activity

    Directory of Open Access Journals (Sweden)

    Seyed Hosein Hoseini

    2012-08-01

    Full Text Available One of the main concerns of people in modern societies is increasing the Body Mass Index (BMI level.BMI, in fact, can be considered as an indicator of overall health condition. Genetic aspects aside, the BMIlevel is affected by different factors, such as socio-economic, environmental, and physical activity level.This study investigated the effect of different factors on the BMI level of a sample population of 470 adultsof three residential neighbourhoods in Shiraz, Iran. The Pearson correlation test, independent sample Ttest and One Way ANOVA were used to extract the variables which significantly influenced the BMI. Thestatistical analysis showed that despite the apparent association of BMI with physical activity level, it isinfluenced by several factors such as age, residence record, number of children, distance to bus or taxistop, indoor or sport exercise. Then, an Artificial Neural Network (ANN was applied to predict the level ofpersonal BMI. The results of this analysis showed that the generalized estimating ANN model wassatisfactory in estimating the BMI based on the introduced pattern

  17. Application of Artificial Neural Network (ANN in Estimation of Body Mass Index (BMI Based on the Connection Between Environmental Factors and Physical Activity

    Directory of Open Access Journals (Sweden)

    Seyed Hosein Hoseini

    2012-07-01

    Full Text Available One of the main concerns of people in modern societies is increasing the Body Mass Index (BMI level. BMI, in fact, can be considered as an indicator of overall health condition. Genetic aspects aside, the BMI level is affected by different factors, such as socio-economic, environmental, and physical activity level. This study investigated the effect of different factors on the BMI level of a sample population of 470 adults of three residential neighbourhoods in Shiraz, Iran. The Pearson correlation test, independent sample Ttest and One Way ANOVA were used to extract the variables which significantly influenced the BMI. The statistical analysis showed that despite the apparent association of BMI with physical activity level, it is influenced by several factors such as age, residence record, number of children, distance to bus or taxi stop, indoor or sport exercise. Then, an Artificial Neural Network (ANN was applied to predict the level of personal BMI. The results of this analysis showed that the generalized estimating ANN model was satisfactory in estimating the BMI based on the introduced pattern.

  18. Comparison of ultrasonic with stirrer performance for removal of sunset yellow (SY) by activated carbon prepared from wood of orange tree: artificial neural network modeling.

    Science.gov (United States)

    Ghaedi, A M; Ghaedi, M; Karami, P

    2015-03-05

    The present work focused on the removal of sunset yellow (SY) dye from aqueous solution by ultrasound-assisted adsorption and stirrer by activated carbon prepared from wood of an orange tree. Also, the artificial neural network (ANN) model was used for predicting removal (%) of SY dye based on experimental data. In this study a green approach was described for the synthesis of activated carbon prepared from wood of an orange tree and usability of it for the removal of sunset yellow. This material was characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The impact of variables, including initial dye concentration (mg/L), pH, adsorbent dosage (g), sonication time (min) and temperature (°C) on SY removal were studied. Fitting the experimental equilibrium data of different isotherm models such as Langmuir, Freundlich, Temkin and Dubinin-Radushkevich models display the suitability and applicability of the Langmuir model. Analysis of experimental adsorption data by different kinetic models including pseudo-first and second order, Elovich and intraparticle diffusion models indicate the applicability of the second-order equation model. The adsorbent (0.5g) is applicable for successful removal of SY (>98%) in short time (10min) under ultrasound condition.

  19. Modified high-density lipoproteins by artificial sweetener, aspartame, and saccharin, showed loss of anti-atherosclerotic activity and toxicity in zebrafish.

    Science.gov (United States)

    Kim, Jae-Yong; Park, Ki-Hoon; Kim, Jihoe; Choi, Inho; Cho, Kyung-Hyun

    2015-01-01

    Safety concerns have been raised regarding the association of chronic consumption of artificial sweeteners (ASs) with metabolic disorders, especially in the heart and brain. There has been no information on the in vivo physiological effects of AS consumption in lipoprotein metabolism. High-dosage treatment (final 25, 50, and 100 mM) with AS (aspartame, acesulfame K, and saccharin) to human high-density lipoprotein (HDL) induced loss of antioxidant ability along with elevated atherogenic effects. Aspartame-treated HDL3 (final 100 mM) almost all disappeared due to putative proteolytic degradation. Aspartame- and saccharin-treated HDL3 showed more enhanced cholesteryl ester transfer activity, while their antioxidant ability was disappeared. Microinjection of the modified HDL3 exacerbated the inflammatory death in zebrafish embryos in the presence of oxLDL. These results show that AS treatment impaired the beneficial functions of HDL, resulting in loss of antioxidant and anti-atherogenic activities. These results suggest that aspartame and saccharin could be toxic to the human circulation system as well as embryonic development via impairment of lipoprotein function.

  20. Isolation of oxygenase genes for indigo-forming activity from an artificially polluted soil metagenome by functional screening using Pseudomonas putida strains as hosts.

    Science.gov (United States)

    Nagayama, Hirofumi; Sugawara, Tomonori; Endo, Ryo; Ono, Akira; Kato, Hiromi; Ohtsubo, Yoshiyuki; Nagata, Yuji; Tsuda, Masataka

    2015-05-01

    Metagenomes contain the DNA from many microorganisms, both culturable and non-culturable, and are a potential resource of novel genes. In this study, a 5.2-Gb metagenomic DNA library was constructed from a soil sample (artificially polluted with four aromatic compounds, i.e., biphenyl, phenanthrene, carbazole, and 3-chlorobenzoate) in Escherichia coli by using a broad-host-range cosmid vector. The resultant library was introduced into naphthalene-degrading Pseudomonas putida-derived strains having deficiencies in their naphthalene dioxygenase components, and indigo-forming clones on the indole-containing agar plates were screened. Cosmids isolated from 29 positive clones were classified by their various properties (original screening hosts, hosts showing indigo-forming activity, and digestion patterns with restriction enzymes), and six representative cosmids were chosen. Sequencing and in vitro transposon mutagenesis of the six cosmids resulted in the identification of genes encoding putative class B and D flavoprotein monooxygenases, a multicomponent hydroxylase, and a reductase that were responsible for the indigo-forming activity in the host cells. Among them, the genes encoding the multicomponent hydroxylase were demonstrated to be involved in phenol degradation. Furthermore, two genes encoding ring-cleavage dioxygenases were also found adjacent to the genes responsible for the indigo formation, and their functions were experimentally confirmed.

  1. The properties of discs around planets and brown dwarfs as evidence for disc fragmentation

    CERN Document Server

    Stamatellos, Dimitris

    2015-01-01

    Direct imaging searches have revealed many very low-mass objects, including a small number of planetary mass objects, as wide-orbit companions to young stars. The formation mechanism of these objects remains uncertain. In this paper we present the predictions of the disc fragmentation model regarding the properties of the discs around such low-mass objects. We find that the discs around objects that have formed by fragmentation in discs hosted by Sun-like stars (referred to as 'parent' discs and 'parent' stars) are more massive than expected from the ${M}_{\\rm disc}-M_*$ relation (which is derived for stars with masses $M_*>0.2 {\\rm M}_{\\odot}$). Accordingly, the accretion rates onto these objects are also higher than expected from the $\\dot{M}_*-M_*$ relation. Moreover there is no significant correlation between the mass of the brown dwarf or planet with the mass of its disc nor with the accretion rate from the disc onto it. The discs around objects that form by disc fragmentation have larger than expected m...

  2. Stellar irradiated discs and implications on migration of embedded planets II: accreting-discs

    CERN Document Server

    Bitsch, Bertram; Lega, Elena; Crida, Aurélien

    2014-01-01

    The strength and direction of migration of embedded low mass planets depends on the disc's structure. It has been shown that, in discs with viscous heating and radiative transport, the migration can be directed outwards. In this paper we investigate the influence of a constant dM/dt-flux through the disc, as well as the influence of the disc's metallicity on the disc's thermodynamics. We focus on dM/dt discs, which have a net mass flux through them. Utilizing the resulting disc structure, we determine the regions of outward migration in the disc. We perform numerical hydrosimulations of dM/dt discs with viscous heating, radiative cooling and stellar irradiation in 2D in the r-z-plane. We use the explicit/implicit hydrodynamical code FARGOCA that includes a full tensor viscosity and stellar irradiation, as well as a two temperature solver that includes radiation transport in the flux-limited diffusion approximation. The migration of embedded planets is studied by using torque formulae. For a disc of gas surfac...

  3. IKKβ-Targeted Anti-Inflammatory Activities of a Butanol Fraction of Artificially Cultivated Cordyceps pruinosa Fruit Bodies

    Science.gov (United States)

    Kim, Han Gyung; Yang, Woo Seok; Sung, Gi-Ho; Kim, Ji Hye; Kim, Eunji; Yang, Sungjae; Park, Yung Chul; Sung, Jae Mo; Yoon, Deok Hyo; Kim, Tae Woong; Hong, Sungyoul; Kim, Jong-Hoon

    2014-01-01

    The inhibitory activities of the Cordyceps pruinosa butanol fraction (Cp-BF) were investigated by determining inflammatory responses of lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells and by evaluating HCl/ethanol (EtOH)-triggered gastric ulcers in mice. The molecular mechanisms of the inhibitory effects of Cp-BF were investigated by identifying target enzymes using biochemical and molecular biological approaches. Cp-BF strongly inhibited the production of NO and TNF-α, release of reactive oxygen species (ROS), phagocytic uptake of FITC-dextran, and mRNA expression levels of interleukin (IL)-6, inducible NO synthase (iNOS), and tumour necrosis factor-alpha (TNF)-α in activated RAW264.7 cells. Cp-BF also strongly downregulated the NF-κB pathway by suppressing IKKβ according to luciferase reporter assays and immunoblot analysis. Furthermore, Cp-BF blocked both increased levels of NF-κB-mediated luciferase activities and phosphorylation of p65/p50 observed by IKKβ overexpression. Finally, orally administered Cp-BF was found to attenuate gastric ulcer and block the phosphorylation of IκBα induced by HCl/EtOH. Therefore, these results suggest that the anti-inflammatory activity of Cp-BF may be mediated by suppression of IKKα and its downstream NF-κB activation. Since our group has established the mass cultivation conditions by developing culture conditions for Cordyceps pruinosa, the information presented in this study may be useful for developing new anti-inflammatory agents. PMID:25132860

  4. IKK β -Targeted Anti-Inflammatory Activities of a Butanol Fraction of Artificially Cultivated Cordyceps pruinosa Fruit Bodies

    Directory of Open Access Journals (Sweden)

    Han Gyung Kim

    2014-01-01

    Full Text Available The inhibitory activities of the Cordyceps pruinosa butanol fraction (Cp-BF were investigated by determining inflammatory responses of lipopolysaccharide (LPS-treated RAW264.7 macrophage cells and by evaluating HCl/ethanol (EtOH-triggered gastric ulcers in mice. The molecular mechanisms of the inhibitory effects of Cp-BF were investigated by identifying target enzymes using biochemical and molecular biological approaches. Cp-BF strongly inhibited the production of NO and TNF-α, release of reactive oxygen species (ROS, phagocytic uptake of FITC-dextran, and mRNA expression levels of interleukin (IL-6, inducible NO synthase (iNOS, and tumour necrosis factor-alpha (TNF-α in activated RAW264.7 cells. Cp-BF also strongly downregulated the NF-κB pathway by suppressing IKKβ according to luciferase reporter assays and immunoblot analysis. Furthermore, Cp-BF blocked both increased levels of NF-κB-mediated luciferase activities and phosphorylation of p65/p50 observed by IKKβ overexpression. Finally, orally administered Cp-BF was found to attenuate gastric ulcer and block the phosphorylation of IκBα induced by HCl/EtOH. Therefore, these results suggest that the anti-inflammatory activity of Cp-BF may be mediated by suppression of IKKα and its downstream NF-κB activation. Since our group has established the mass cultivation conditions by developing culture conditions for Cordyceps pruinosa, the information presented in this study may be useful for developing new anti-inflammatory agents.

  5. Artificiality in Social Sciences

    OpenAIRE

    Rennard, Jean-Philippe

    2007-01-01

    This text provides with an introduction to the modern approach of artificiality and simulation in social sciences. It presents the relationship between complexity and artificiality, before introducing the field of artificial societies which greatly benefited from the computer power fast increase, gifting social sciences with formalization and experimentation tools previously owned by "hard" sciences alone. It shows that as "a new way of doing social sciences", artificial societies should undo...

  6. Artificial life and Piaget.

    Science.gov (United States)

    Mueller, Ulrich; Grobman, K H.

    2003-04-01

    Artificial life provides important theoretical and methodological tools for the investigation of Piaget's developmental theory. This new method uses artificial neural networks to simulate living phenomena in a computer. A recent study by Parisi and Schlesinger suggests that artificial life might reinvigorate the Piagetian framework. We contrast artificial life with traditional cognitivist approaches, discuss the role of innateness in development, and examine the relation between physiological and psychological explanations of intelligent behaviour.

  7. Stem cells sources for intervertebral disc regeneration

    Institute of Scientific and Technical Information of China (English)

    Gianluca; Vadalà; Fabrizio; Russo; Luca; Ambrosio; Mattia; Loppini; Vincenzo; Denaro

    2016-01-01

    Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible treatments.Indeed, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers(e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

  8. Have proto-planetary discs formed planets?

    CERN Document Server

    Greaves, J S

    2010-01-01

    It has recently been noted that many discs around T Tauri stars appear to comprise only a few Jupiter-masses of gas and dust. Using millimetre surveys of discs within six local star-formation regions, we confirm this result, and find that only a few percent of young stars have enough circumstellar material to build gas giant planets, in standard core accretion models. Since the frequency of observed exo-planets is greater than this, there is a `missing mass' problem. As alternatives to simply adjusting the conversion of dust-flux to disc mass, we investigate three other classes of solution. Migration of planets could hypothetically sweep up the disc mass reservoir more efficiently, but trends in multi-planet systems do not support such a model, and theoretical models suggest that the gas accretion timescale is too short for migration to sweep the disc. Enhanced inner-disc mass reservoirs are possible, agreeing with predictions of disc evolution through self-gravity, but not adding to millimetre dust-flux as t...

  9. The tidal disruption of protoplanetary accretion discs

    CERN Document Server

    Larwood, J D

    1997-01-01

    In this paper we revisit the problem of the tidal interaction occuring between a protostellar accretion disc and a secondary point mass following a parabolic trajectory. We model the disc response analytically and we compare our results with three-dimensional SPH simulations. Inviscid as well as viscous hydrodynamics is considered. We show that in a viscous system the response derived from inviscid considerations is predominant even for the highest estimates of an anomalous disc shear viscosity. The angular momentum lost from the disc during the encounter is derived from linear theory, for distant fly-bys, as well as the changes to the disc orientation expected in non-coplanar encounters. It is shown that the target discs can become warped and precess by a small amount during non-coplanar encounters. This small precession is shown to give rise to a relative tilt of the disc which is always more important for determining its final orientation than is the change to the orbital inclination. We discuss the implic...

  10. Stem cells sources for intervertebral disc regeneration.

    Science.gov (United States)

    Vadalà, Gianluca; Russo, Fabrizio; Ambrosio, Luca; Loppini, Mattia; Denaro, Vincenzo

    2016-05-26

    Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible treatments. Indeed, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers (e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

  11. Optically-thick accretion discs with advection

    Institute of Scientific and Technical Information of China (English)

    陈林红; 吴枚; 尚仁成

    2002-01-01

    The structures of optically-thick accretion discs with radial advection have been investigated by the iteration and integration algorithms. The advective cooling term changes mostly the inner part of disc solution, and even results in an optically-thick advection-dominated accretion flow (ADAF). Three distinct branches-the outer Shakura-Sunyaev disc (SSD), the inner ADAF and the middle transition layer-are found for a super-Eddington disc. The SSD-ADAF transition radius can be estimated as 18(M/ME)RG where RG is the Schwarzschild radius, M is the mass accretion rate and ME is the Eddington accretion rate. SSD solutions calculated with the iteration and integration methods are identical, while ADAF solutions obtained by these two methods differ greatly. Detailed algorithms and their differences have been analysed. The iteration algorithm is not self-consistent, since it implies that the dimensionless advection factor ξ is invariant, but in the inner ADAF region the variation of ξ is not negligible. The integration algorithm is always effective for the whole region of an optically-thick disc if the accretion rate is no smaller than 10-4ME. For optically-thin discs, the validity of these two algorithms is different. We suggest that the integration method be employed to calculate the global solution of a disc model without assuming ξ to be a constant. We also discuss its application to the emergent continuum spectrum in order to explain observational facts.

  12. Chemical separation of disc components using RAVE

    CERN Document Server

    Wojno, Jennifer; Steinmetz, Matthias; McMillan, Paul J; Matijevič, Gal; Binney, James; Wyse, Rosemary F G; Boeche, Corrado; Just, Andreas; Grebel, Eva K; Siebert, Arnaud; Bienaymé, Olivier; Gibson, Brad K; Zwitter, Tomaž; Bland-Hawthorn, Joss; Navarro, Julio F; Parker, Quentin A; Reid, Warren; Seabroke, George; Watson, Fred

    2016-01-01

    We present evidence from the RAdial Velocity Experiment (RAVE) survey of chemically separated, kinematically distinct disc components in the solar neighbourhood. We apply probabilistic chemical selection criteria to separate our sample into $\\alpha$-low (`thin disc') and $\\alpha$-high (`thick disc') components. Using newly derived distances, which will be utilized in the upcoming RAVE DR5, we explore the kinematic trends as a function of metallicity for each of the disc components. For our thin disc stars, we find a negative trend in the mean rotational velocity ($V_{\\mathrm{\\phi}}$) as a function of iron abundance ([Fe/H]). We measure a positive trend in $\\partial V_{\\mathrm{\\phi}}$/$\\partial$[Fe/H] for the thick disc, consistent with results from high-resolution surveys. We also find differences between the chemical thin and thick discs in all three components of velocity dispersion. We discuss the implications of an $\\alpha$-low, metal-rich population originating from the inner Galaxy, where the orbits of ...

  13. Structure of radiation dominated gravitoturbulent quasar discs

    CERN Document Server

    Shadmehri, Mohsen; Dib, Sami

    2016-01-01

    Self-gravitating accretion discs in a gravitoturbulent state, including radiation and gas pressures, are studied using a set of new analytical solutions. While the Toomre parameter of the disc remains close to its critical value for the onset of gravitational instability, the dimensionless stress parameter is uniquely determined from the thermal energy reservoir of the disc and its cooling rate. Our solutions are applicable to the accretion discs with dynamically important radiation pressure like in the quasars discs. We show that physical quantities of a gravitoturbulent disc in the presence of radiation are significantly modified compared to solutions with only gas pressure. We show that the dimensionless stress parameter is an increasing function of the radial distance so that its steepness strongly depends on the accretion rate. In a disc without radiation its slope is 4.5, however, we show that in the presence of radiation, it varies between 2 and 4.5 depending on the accretion rate and the central mass....

  14. Pre-Fukushima levels of artificial radionuclides activities in maritime samples from King George Island (South Shetlands, Antarctica)

    Energy Technology Data Exchange (ETDEWEB)

    Sobiech-Matura, K. [European Commision DG-JRC Institute for Reference Materials and Measurements, Retieseweg 111, Geel (Belgium); Institute of Botany, Zdzislaw Czeppe Department of Polar Research and Documentation, Jagiellonian University, Kopernika 27, Krakow (Poland); Mietelski, J.W. [The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, W.E. Radzikowskiego 152, Krakow (Poland); Olech, M.A. [Institute of Botany, Zdzislaw Czeppe Department of Polar Research and Documentation, Jagiellonian University, Kopernika 27, Krakow (Poland); Department of Antarctic Biology, Polish Academy of Sciences, Ustrzycka 10/12, Warsaw (Poland)

    2014-07-01

    Different maritime samples were collected at King George Island during Polish scientific expeditions in years 2005/2006 and 2006/2007. They originated mainly from Admiralty Bay region. Activities of {sup 137}Cs, {sup 238,239+240}Pu, {sup 90}Sr and {sup 241}Am were measured using γ-, β- and α-spectrometry. Our measurements allow estimating the state of radioactive pollution of Antarctic environment directly before the Fukushima accident. Examined samples included different elements of Antarctic marine environment: macro-algae (e.g. Cystosphaera jacquinotii, Ascoseira mirabilis), fishes(e.g. Notothenia coriiceps, Chaenocephalus aceratus), birds (e.g. Pygoscelis adeliae, P. papua), and crustaceans (e.g. Euphausia superba, Waldeckia obesa). Activity concentrations of {sup 137}Cs vary from <0.3 to 21.8 ± 2.1 Bq/kg d.w. In comparison with results obtained for samples of animals and macro-algae previously [1,2] our results are similar or lower. Activity concentrations of {sup 239+240}Pu range from <0.2 to 455 ± 56 mBq/kg d.w. and comparing to previous results [1,2] they were similar or lower. For maritime animals from Terra Nova Bay [3] results are also similar or lower than obtained in present project. Activity concentrations of {sup 238}Pu in samples varied from <0.2 to 79 ± 22 mBq/kg d.w. In comparison to results presented in [1,2,3] our values are similar or higher. Activity concentrations obtained for {sup 90}Sr varied from <1.5 to 73 ± 24 Bq/kg d.w. and are similar or lower then values given in [2,3]. Activity concentrations of {sup 241}Am varied from <9.4 to 29.8 ± 9.3 mBq/kg d.w. and they are similar or higher than values obtained in [3] and similar to that from [1]. Obtained results show that levels of radioactive contamination were very low and in many cases lower than the detection limit. Planned further investigation will allow estimating the environmental condition after the Fukushima accident. (authors)

  15. The role of cryopreservation in the biomechanical properties of the intervertebral disc

    Directory of Open Access Journals (Sweden)

    SKL Lam

    2011-12-01

    Full Text Available Implantation of intervertebral disc (IVD allograft or tissue engineered disc constructs in the spine has emerged as an alternative to artificial disc replacement for the treatment of severe degenerative disc disease (DDD. Establishment of a bank of cryopreserved IVD allografts enables size matching and facilitates logistics for effective clinical management. However, the biomechanical properties of cryopreserved IVDs have not been previously reported. This study aimed to assess if cryopreservation with different concentrations of cryopreservant agents (CPA would affect the dynamic viscoelastic properties of the IVD. Whole porcine lumbar IVDs (n = 40 were harvested and processed using various concentrations of CPA, 0 % CPA, 10 % CPA and 20 % CPA. The discs were cryopreserved using a stepwise freezing protocol and stored in liquid nitrogen. After four weeks of storage, the cryopreserved IVDs were quickly thawed at 37 °C for dynamic viscoelastic testing. The apparent modulus, elastic modulus (G’, viscous modulus (G” and loss modulus (G”/G’ were calculated and compared to a fresh control group. Cryopreserved IVD without cryopreservants was significantly stiffer than the control. In the dynamic viscoelastic testing, cryopreservation with the use of CPA was able to preserve both G’ and G” of an IVD. No significant differences were found between fresh IVD and IVD cryopreserved with 10 % CPA or 20 % CPA. This study demonstrated that CPAs at an optimal concentration could preserve the mechanical properties of the IVD allograft and can provide further credence for the application of long-term storage of IVD allografts for disc transplantation or tissue engineered construct applications.

  16. Effects of voluntary exercise on spontaneous physical activity and food consumption in mice: Results from an artificial selection experiment.

    Science.gov (United States)

    Copes, Lynn E; Schutz, Heidi; Dlugosz, Elizabeth M; Acosta, Wendy; Chappell, Mark A; Garland, Theodore

    2015-10-01

    We evaluated the effect of voluntary exercise on spontaneous physical activity (SPA) and food consumption in mice from 4 replicate lines bred for 57 generations for high voluntary wheel running (HR) and from 4 non-selected control (C) lines. Beginning at ~24 days of age, mice were housed in standard cages or in cages with attached wheels. Wheel activity and SPA were monitored in 1-min intervals. Data from the 8th week of the experiment were analyzed because mice were sexually mature and had plateaued in body mass, weekly wheel running distance, SPA, and food consumption. Body mass, length, and masses of the retroperitoneal fat pad, liver, and heart were recorded after the 13th week. SPA of both HR and C mice decreased with wheel access, due to reductions in both duration and average intensity of SPA. However, total activity duration (SPA+wheel running; min/day) was ~1/3 greater when mice were housed with wheels, and food consumption was significantly increased. Overall, food consumption in both HR and C mice was more strongly affected by wheel running than by SPA. Duration of wheel running had a stronger effect than average speed, but the opposite was true for SPA. With body mass as a covariate, chronic wheel access significantly reduced fat pad mass and increased heart mass in both HR and C mice. Given that both HR and C mice housed with wheels had increased food consumption, the energetic cost of wheel running was not fully compensated by concomitant reductions in SPA. The experiment demonstrates that both duration and intensity of both wheel running and SPA were significant predictors of food consumption. This sort of detailed analysis of the effects of different aspects of physical activity on food consumption has not previously been reported for a non-human animal, and it sets the stage for longitudinal examination of energy balance and its components in rodent models.

  17. The effects of high-frequency oscillations in hippocampal electrical activities on the classification of epileptiform events using artificial neural networks

    Science.gov (United States)

    Chiu, Alan W. L.; Jahromi, Shokrollah S.; Khosravani, Houman; Carlen, Peter L.; Bardakjian, Berj L.

    2006-03-01

    The existence of hippocampal high-frequency electrical activities (greater than 100 Hz) during the progression of seizure episodes in both human and animal experimental models of epilepsy has been well documented (Bragin A, Engel J, Wilson C L, Fried I and Buzsáki G 1999 Hippocampus 9 137-42 Khosravani H, Pinnegar C R, Mitchell J R, Bardakjian B L, Federico P and Carlen P L 2005 Epilepsia 46 1-10). However, this information has not been studied between successive seizure episodes or utilized in the application of seizure classification. In this study, we examine the dynamical changes of an in vitro low Mg2+ rat hippocampal slice model of epilepsy at different frequency bands using wavelet transforms and artificial neural networks. By dividing the time-frequency spectrum of each seizure-like event (SLE) into frequency bins, we can analyze their burst-to-burst variations within individual SLEs as well as between successive SLE episodes. Wavelet energy and wavelet entropy are estimated for intracellular and extracellular electrical recordings using sufficiently high sampling rates (10 kHz). We demonstrate that the activities of high-frequency oscillations in the 100-400 Hz range increase as the slice approaches SLE onsets and in later episodes of SLEs. Utilizing the time-dependent relationship between different frequency bands, we can achieve frequency-dependent state classification. We demonstrate that activities in the frequency range 100-400 Hz are critical for the accurate classification of the different states of electrographic seizure-like episodes (containing interictal, preictal and ictal states) in brain slices undergoing recurrent spontaneous SLEs. While preictal activities can be classified with an average accuracy of 77.4 ± 6.7% utilizing the frequency spectrum in the range 0-400 Hz, we can also achieve a similar level of accuracy by using a nonlinear relationship between 100-400 Hz and <4 Hz frequency bands only.

  18. Endoscopic anterior decompression in cervical disc disease

    Directory of Open Access Journals (Sweden)

    Yad Ram Yadav

    2014-01-01

    Full Text Available Background: Although microscopic anterior cervical discectomy with or without fusion are common surgical procedures for treatment of cervical herniated discs, loss of disc height, pseudarthrosis, and adjacent disc degeneration are some of the problems associated with it. This study is aimed to evaluate results of endoscopic microforaminotomy in cervical disc diseases. Materials and Methods: A prospective study of 50 patients of mono segmental soft or hard disc causing myeloradiculopathy was undertaken. A visual analogue scale (VAS for neck and arm pain and functional outcomes using the Nurick grading system were assessed. There were 28, 12, 8, and 2 patients at C5-6, C6-7, C4-5, and C3-4 levels disc diseases, respectively. Patients with two or more level disc, instabilities, disc extending more than half vertebral body height, and previous operation at the same segment were excluded. Results: Age ranged from 21 to 67 years. Average postoperative reduction in disc height, operating time, and blood loss was 1.1 mm, 110 minutes, and 30 ml, respectively. Average pre-operative VAS score for arm pain and Nurick grading was 7.6 and 2.7, which improved to 1.9 and 0.82, respectively. All patients improved; 1, 2, 3 grade improvement was seen in 10, 27, and 10 patients, respectively. There was no significant complication or any mortality. Conclusion: Although longer follow up of large number of patients is required, endoscopic microforaminotomy is a safe and an effective alternative to microscopic anterior discectomy with or without fusion.

  19. The Change Indices of Solar and Geomagnetic Activity and Their Influence on the Dynamics of Drag of Artificial Satellite

    Science.gov (United States)

    Komendant, V. H.; Koshkin, N. I.; Ryabov, M. I.; Sukharev, A. L.

    2016-12-01

    The time-frequency and multiple regression analysis of the orbital parameter characterizing the drag of satellites on circular and elliptical orbits with different perigees and orbital inclinations in the atmosphere of the Earth was being conducted in 23-24 cycles of solar activity. Among the factors influencing braking dynamics of satellites were taken: W - Wolf numbers; Sp - the total area of sunspot groups of the northern and southern hemispheres of the Sun, F10.7 - the solar radio flux at 10,7 cm; E - electron flux with energies more than 0,6 MeV è 2 MeV; planetary, high latitude and middle latitude geomagnetic index Ap. In the atmospheric drag dynamics of satellites, the following periods were detected: 6-year, 2.1-year, annual, semi-annual, 27-days, 13- and 11-days. Similar periods are identified in indexes of solar and geomagnetic activity. Dependence of the periods of satellites motion on extremes of solar activities and space weather conditions was conducted.

  20. Modeling and Thermal Analysis of Disc

    OpenAIRE

    Brake Praveena S; Lava Kumar M

    2014-01-01

    The disc brake is a device used for slowing or stopping the rotation of the vehicle. Number of times using the brake for vehicle leads to heat generation during braking event, such that disc brake undergoes breakage due to high Temperature. Disc brake model is done by CATIA and analysis is done by using ANSYS workbench. The main purpose of this project is to study the Thermal analysis of the Materials for the Aluminum, Grey Cast Iron, HSS M42, and HSS M2. A comparison between ...

  1. Groups, cacti and framed little discs

    CERN Document Server

    Hepworth, Richard

    2010-01-01

    Let G be a topological group. Then the based loopspace of G is an algebra over the cacti operad, while the double loopspace of the classifying space of G is an algebra over the framed little discs operad. This paper shows that these two algebras are equivalent, in the sense that they are weakly equivalent E-algebras, where E is an operad weakly equivalent to both framed little discs and cacti. We recover the equivalence between cacti and framed little discs, and Menichi's isomorphism between the BV-algebras obtained by taking the homology of the loopspace of G and of the double loopspace of BG.

  2. A lumbar disc surgery predictive score card.

    Science.gov (United States)

    Finneson, B E

    1978-06-01

    A lumbar disc surgery predictive score card or questionnaire has been developed to assess potential candidates for excision of a herniated lumbar disc who have not previously undergone lumbar spine surgery. It is not designed to encompass patients who are being considered for other types of lumbar spine surgery, such as decompressive laminectomy or fusion. In an effort to make the "score card" usable by almost all physicians who are involved in lumbar disc surgery, only studies which have broad acceptance and are generally employed are included. Studies which have less widespread use such as electromyogram, discogram, venogram, special psychologic studies (MMPI, pain drawings) have been purposely excluded.

  3. Spectroscopic Parameters of Lumbar Intervertebral Disc Material

    Science.gov (United States)

    Terbetas, G.; Kozlovskaja, A.; Varanius, D.; Graziene, V.; Vaitkus, J.; Vaitkuviene, A.

    2009-06-01

    There are numerous methods of investigating intervertebral disc. Visualization methods are widely used in clinical practice. Histological, imunohistochemical and biochemical methods are more used in scientific research. We propose that a new spectroscopic investigation would be useful in determining intervertebral disc material, especially when no histological specimens are available. Purpose: to determine spectroscopic parameters of intervertebral disc material; to determine emission spectra common for all intervertebral discs; to create a background for further spectroscopic investigation where no histological specimen will be available. Material and Methods: 20 patients, 68 frozen sections of 20 μm thickness from operatively removed intervertebral disc hernia were excited by Nd:YAG microlaser STA-01-TH third harmonic 355 nm light throw 0, 1 mm fiber. Spectrophotometer OceanOptics USB2000 was used for spectra collection. Mathematical analysis of spectra was performed by ORIGIN multiple Gaussian peaks analysis. Results: In each specimen of disc hernia were found distinct maximal spectral peaks of 4 types supporting the histological evaluation of mixture content of the hernia. Fluorescence in the spectral regions 370-700 nm was detected in the disc hernias. The main spectral component was at 494 nm and the contribution of the components with the peak wavelength values at 388 nm, 412 nm and 435±5 nm were varying in the different groups of samples. In comparison to average spectrum of all cases, there are 4 groups of different spectral signatures in the region 400-500 nm in the patient groups, supporting a clinical data on different clinical features of the patients. Discussion and Conclusion: besides the classical open discectomy, new minimally invasive techniques of treating intervertebral disc emerge (PLDD). Intervertebral disc in these techniques is assessed by needle, no histological specimen is taken. Spectroscopic investigation via fiber optics through the

  4. Magnetic resonance imaging of artificial lumbar disks: safety and metal artifacts

    Institute of Scientific and Technical Information of China (English)

    YANG Chang-wei; LIU Liu; WANG Jian; DONG Ai-sheng; LU Jian-ping; HE Shi-sheng; LI Ming

    2009-01-01

    Background This study was to investigate the safety of two types of commercially available lumbar artificial discs (CHARITE and PRODISC -L) during a magnetic resonance imaging (MRI) procedure in a 1.5-Tesla MR system, and to evaluate the size of metal artifacts on the MR image for different sequences.Methods A 1.5-Tesla clinical MR imaging system was used. The degree of deflection of the endplates of two artificial discs was evaluated by an angle-measurement instrument at the portals of the MRI scanner. The heating effect of the radio frequency (RF) magnetic field was evaluated by using "worst-case" imaging sequences on a human cadaver implanted with an artificial lumbar disc at the L5/S1 intervertebral disc location. The temperatures of the tissue adjacent to the implant, and of the L4/L5 intervertebral disc (used as a control) were measured, respectively, using a digital probe thermometer before and after the MRI scan sequence. A rectangular water phantom was designed to evaluate the metal artifacts of these two artificial discs under different MR imaging sequences.Results The maximal deflection angle of the endplate of the implants under a static MR field was 7.5 and 6.0 degrees, for the CHARITE and PRODISC -L, respectively. The difference between temperature rise of tissue adjacent to the two types of artificial discs and the temperature rise of the L4/L5 control location was 0.4 and 0.6℃, respectively. The size of metal artifacts on images of TSE (T1/T2-weighted), STIR and Turbo Dark Fluid sequences were relatively less than those of TSE fat saturation, Flash and SE (T1-weighted) sequences.Conclusions The CHARITE and the PRODISC -L artificial disc do not present an additional hazard or risk to a patient undergoing an MRI procedure using a scanner operating with a static magnetic field of 1.5T or lower. Image artifacts from the implants may present problems if the anatomical region of interest is in or near the area where these implants are located (e

  5. Thanatology in Protoplanetary Discs: the combined influence of Ohmic, Hall, and ambipolar diffusion on dead zones

    CERN Document Server

    Lesur, Geoffroy; Fromang, Sebastien

    2014-01-01

    Protoplanetary discs are poorly ionised due to their low temperatures and high column densities, and are therefore subject to three "non-ideal" magnetohydrodynamic effects: Ohmic dissipation, ambipolar diffusion, and the Hall effect. The existence of magnetically driven turbulence in these discs has been a central question since the discovery of the magnetorotational instability. Early models considered Ohmic diffusion only and led to a scenario of layered accretion, in which a magnetically "dead" zone in the disc midplane is embedded within magnetically "active" surface layers at distances ~1-10 au from the central protostellar object. Recent work has suggested that a combination of Ohmic dissipation and ambipolar diffusion can render both the midplane and surface layers of the disc inactive and that torques due to magnetically driven outflows are required to explain the observed accretion rates. We reassess this picture by performing three-dimensional numerical simulations that include, for the first time, ...

  6. 基于人工神经网络的无机抗菌剂抗菌性能预测模型%Predictiong Model of Antibacterial Activities for Inorganic Antibacterial Agents Based on Artificial Neural Networks

    Institute of Scientific and Technical Information of China (English)

    刘雪峰; 张利; 涂铭旌

    2004-01-01

    Quantitatively evaluation of antibacterial activities of inorganic antibacterial agents is an urgent problem to be solved.Using experimental data by an orthogonal design, a prediction model of the relation between conditions of preparing inorganic antibacterial agents and their antibacterial activities has been developed.This is accomplished by introducing BP artificial neural networks in the study of inorganic antibacterial agents.It provides a theoretical support for the development and research on inorganic antibacterial agents.

  7. Investigation of the coatings applied onto brake discs on disc-brake pad pair

    Directory of Open Access Journals (Sweden)

    I. Kiliçaslan

    2009-07-01

    Full Text Available While braking, according to the severity of it, thermal, metallurgical, constructive and tribological occurrences emerge on the brake disc-pad interface. In this study, NiCr was sprayed as bonding layer onto the discs, one ofwhich was coated with Al2O3-TiO2 by plasma spray and the other was coated with NiCr-Cr3C2 by High Velocity Oxygen Fuel (HVOF. In addition, the discs were tested with inertia dynamometer according to SAE’s J2522 testing procedure. The measurements showed that although the pads of the coated discs were exposed to higher braking temperatures, friction coefficient of the disc coated with NiCr- Cr3C2 was obtained 6 % higher compared to the original disc.

  8. Stellar irradiated discs and implications on migration of embedded planets I: equilibrium discs

    CERN Document Server

    Bitsch, Bertram; Morbidelli, Alessandro; Kley, Willy; Dobbs-Dixon, Ian

    2012-01-01

    The strength and direction of migration of low mass planets depends on the disc's thermodynamics. In discs where the viscous heating is balanced by radiative transport, the migration can be directed outwards, a process which extends the lifetime of growing planetary embryos. We investigate the influence of opacity and stellar irradiation on the disc thermodynamics. Utilizing the resulting disc structure, we determine the regions of outward migration. We perform two-dimensional numerical simulations of equilibrium discs with viscous heating, radiative cooling and stellar irradiation. We use the hydrodynamical code NIRVANA that includes a full tensor viscosity and stellar irradiation, as well as a two temperature solver that includes radiation transport in the flux-limited diffusion approximation. The migration is studied by using torque formulae. In the constant opacity case, we reproduce the analytical results of a black-body disc: the stellar irradiation dominates in the outer regions -- leading to flaring -...

  9. Magnetorotationally driven wind cycles in local disc models

    CERN Document Server

    Riols, A; Latter, H; Ross, J P

    2016-01-01

    Jets, from the protostellar to the AGN context, have been extensively studied but their connection to the turbulent dynamics of the underlying accretion disc is poorly understood. Following a similar approach to Lesur et al. (2013), we examine the role of the magnetorotational instability (MRI) in the production and acceleration of outflows from discs. Via a suite of one-dimensional shearing-box simulations of stratified discs we show that magneto-centrifugal winds exhibit cyclic activity with a period of 10-20 Omega^{-1}, a few times the orbital period. The cycle seems to be more vigorous for strong vertical field; it is robust to the variation of relevant parameters and independent of numerical details. The convergence of these solutions (in particular the mass loss rate) with vertical box size is also studied. By considering a sequence of magnetohydrostatic equilibria and their stability, the periodic activity may be understood as the succession of the following phases: (a) a dominant MRI channel mode, (b)...

  10. Burned-out discs stop hurting: fact or fiction?

    DEFF Research Database (Denmark)

    Bendix, Tom; Kjaer, Per; Korsholm, Lars

    2008-01-01

    ). The risk for LBP during the past year attributed to black discs was 11%. CONCLUSION: The data could not support the hypothesis that severely degenerated discs are "burned out" and become less painful. People with black discs had a higher prevalence of LBP compared to those with grey or normal discs...

  11. Photosynthetic oxygen evolution at low water potential in leaf discs lacking an epidermis.

    Science.gov (United States)

    Tang, A C; Kawamitsu, Y; Kanechi, M; Boyer, John S

    2002-06-01

    Land plants encountering low water potentials (low psiw) close their stomata, restricting CO2 entry and potentially photosynthesis. To determine the impact of stomatal closure, photosynthetic O2 evolution was investigated in leaf discs from sunflower (Helianthus annuus L.) plants after removing the lower epidermis at low psiw. Wounding was minimal as evidenced by O2 evolution nearly as rapid as that in intact discs. O2 evolution was maximal in 1% CO2 in the peeled discs and was markedly inhibited when psiw was below -1.1 MPa. CO2 entered readily at all psiw, as demonstrated by varying the CO2 concentration. Results were the same whether the epidermis was removed before or after low psiw was imposed. Due to the lack of an epidermis and ready movement or CO2 through the mesophyll, the loss in O2 evolving activity was attributed entirely to photosynthetic metabolism. Intact leaf discs showed a similar loss in activity when measured at a CO2 concentration of 5%, which supported maximum O2 evolution at low psiw. In 1% CO2, however, O2 evolution at low psiw was below the maximum, presumably because stomatal closure restricted CO2 uptake. The inhibition was larger than in peeled discs at psiw between -1 and -1.5 MPa but became the same as in peeled discs at lower psiw. Therefore. as photosynthesis began to be inhibited by metabolism at low psiw, stomatal closure added to the inhibition. As psiw became more negative, the inhibition became entirely metabolic.

  12. Reoperations after first lumbar disc herniation surgery; a special interest on residives during a 5-year follow-up

    Directory of Open Access Journals (Sweden)

    Kautiainen Hannu

    2007-01-01

    Full Text Available Abstract Background The overall rate of operations after recurrent lumbar disc herniation has been shown to be 3–11%. However, little is known about the rate of residives. Thus the aim of this study was to explore the cumulative rates of re-operations and especially residive disc herniations at the same side and level as the primary disc herniation after first lumbar disc herniation surgery and the factors that influence the risk of re-operations over a five year follow-up study. Methods 166 virgin lumbar disc herniation patients (mean age 42 years, 57% males were studied. Data on patients' initial disc operations and type and timing of re-operations during the follow-up were collected from patient files. Back and leg pain on visual analog scale and employment status were collected by questionnaires. Results The cumulative rate of re-operations for lumbar disc herniation was 10.2% (95% Cl 6.0 to 15.1. The rate of residives at initial site was 7.4% (95% Cl 3.7 to 11.3 and rate of lumbar disc herniations at other sites was 3.1% (95% Cl 0.6 to 6.2. The occurrence of residive lumbar disc herniations was evenly distributed across the 5 years. Neither age, gender, preoperative symptoms, physical activity nor employment had effect on the probability of re-operation. Conclusion Seven percent of the lumbar disc patients had a residive lumbar disc operation within five years of their first operation. No specific factors influencing the risk for re-operation were found.

  13. Transcript profiling of Paoenia ostii during artificial chilling induced dormancy release identifies activation of GA pathway and carbohydrate metabolism.

    Directory of Open Access Journals (Sweden)

    Shupeng Gai

    Full Text Available Endo-dormant flower buds must pass through a period of chilling to reinitiate growth and subsequent flowering, which is a major obstacle to the forcing culture of tree peony in winter. Customized cDNA microarray (8×15 K element was used to investigate gene expression profiling in tree peony 'Feng Dan Bai' buds during 24 d chilling treatment at 0-4°C. According to the morphological changes after the whole plants were transferred to green house, endo-dormancy was released after 18 d chilling treatment, and prolonged chilling treatment increased bud break rate. Pearson correlation hierarchical clustering of sample groups was highly consistent with the dormancy transitions revealed by morphological changes. Totally 3,174 significantly differentially-expressed genes (P<0.05 were observed through endo-dormancy release process, of which the number of up-regulated (1,611 and that of down-regulated (1,563 was almost the same. Functional annotation of differentially-expressed genes revealed that cellular process, metabolic process, response to stimulus, regulation of biological process and development process were well-represented. Hierarchical clustering indicated that activation of genes involved in carbohydrate metabolism (Glycolysis, Citrate cycle and Pentose phosphate pathway, energy metabolism and cell growth. Based on the results of GO analysis, totally 51 probes presented in the microarray were associated with GA response and GA signaling pathway, and 22 of them were differently expressed. The expression profiles also revealed that the genes of GA biosynthesis, signaling and response involved in endo-dormancy release. We hypothesized that activation of GA pathway played a central role in the regulation of dormancy release in tree peony.

  14. 风湿骨痛药酒药槌外治法对兔退变腰椎间盘内磷脂酶A2活性的影响%The effect of external treatment of medicated mallet of Fengshi Gutong Herb Liquor on phospholipase A2 activity in the degenerative intervertebral disc in rabbit model

    Institute of Scientific and Technical Information of China (English)

    肖强兵; 白书臣; 何承建; 曾俊华; 李浩; 陈大伟

    2011-01-01

    To study the effect of external treatment of medicated mallet of Fengshi Gutong Herb Liquor on phcspholipase A2 activity in the degenerative intervertebral disc in rabbit model and exploring its mechanism of treatment and prevention on discogenic low back pain. Methods 21 rabbits, after modeled by injuring the intervertebral disc percutaneously under X - ray, were randomly divided into 3 groups: mallet of Fengshi Gutong Herb Liquor group, medicine treatment group, model control group. Treatment was given after 8 weeks after modeling, L4 -5 intervertebral disc was sampled for PLA2 activity detection. Results Compared with model control group, PLA2 activity of both treatment groups were significantly lower (P <0.01). No significant difference was observed in comparison between the external treatment group and medicine treatment group (P > 0.05). Conclusion Mallet of Gutong Herb Liquor mallet of Gutong Herb Liquor can lower the PLA2 activity in intervetebral disc, which may be a mechanism of treating dicogenic back pain.%目的 观察风湿骨痛药酒药槌对兔退变椎间盘内磷脂酶A2(PLA2)活性的影响,探讨其防治椎间盘源性下腰痛的机理.方法 采用在X光机透视定位下经皮穿刺破坏椎间盘的造模方法,将21只实验免随机分为3组:风湿骨痛药酒药槌外治法治疗组、药物治疗组和模型对照组.造模8周后开始治疗,3周后手术取L4-5椎间盘进行PLA2活性检测.结果 与模型组比较,两治疗组PLA2活性明显降低(P<0.01).外治法组与药物治疗组比较,PLA2活性无明显差异(P>0.05).结论 风湿骨痛药酒药槌外治法可降低椎间盘内PLA2活性,这可能是其防治椎间盘源性下腰痛的机制之一.

  15. SnO2 nanoparticle-loaded activated carbon for simultaneous removal of Acid Yellow 41 and Sunset Yellow; derivative spectrophotometric, artificial neural network and optimization approach.

    Science.gov (United States)

    Hajati, S; Ghaedi, M; Mahmoudi, Z; Sahraei, R

    2015-11-05

    The simultaneous adsorption of Acid Yellow 41 (AY41) and Sunset Yellow (SY) onto SnO2 nanoparticle-loaded activated carbon (SnO2-NP-AC with very high BET surface area of 1278.71 m(2) g(-1)) was investigated. To overcome the severe dyes spectral overlapping, derivative spectrophotometric method and principal component analysis-artificial neural network (PCA-ANN) were successfully applied for the simultaneous determination of AY41 and SY in their binary solutions. By using central composite design (CCD) under response surface methodology, the effects of variables such as contact time, adsorbent dosage, pH, AY41 concentration and SY concentration on responses such as binary dyes removal percentages were examined. Optimal values were found to be 17.9 min, 0.024 g, 3.1, and 15.9 mg L(-1) and 18.7 mg L(-1), respectively. In binary solutions, the best fit to modified-extended Langmuir isotherm was obtained for the whole concentration range. In binary solutions, a synergism was observed for the AY41 and SY dyes adsorption onto SnO2-NP-AC. The adsorption rates at various times were analyzed. It indicated a pseudo-second-order kinetic model for the adsorption of both dyes.

  16. Treatment of lumbar disc herniation by percutaneous laser disc decompression (PLDD) and modified PLDD

    Science.gov (United States)

    Chi, Xiao fei; Li, Hong zhi; Wu, Ru zhou; Sui, Yun xian

    2005-07-01

    Objective: To study the micro-invasive operative method and to compare the effect of treatment of PLDD and modified PLDD for Lumbar Disc Herniation. Method: Vaporized part of the nucleus pulposus in single or multiple point after acupuncture into lumbar disc, to reach the purpose of the decompression of the lumbar disc. Result: Among the 19 cases of the regular PLDD group, the excellent and good rate was 63.2%, and among the 40 cases of the modified PLDD group, the excellent and good rate was 82.5%. Conclusion: The modified PLDD has good effect on the treatment for lumbar disc herniation.

  17. Transradicular lumbar disc herniation: An extreme variant of intraradicular disc herniation.

    Science.gov (United States)

    Kasliwal, Manish K; Shimer, Adam L

    2015-01-01

    Intradural or intraradicular lumbar disc herniation (IDH) is a relatively rare condition often diagnosed intraoperatively. We encountered an extreme variant of IDH - a transradicular herniation as the disc material extruded through the lumbar nerve root through a split essentially transecting the nerve root. While failure to recognize intradural and intraradicular disc herniation can lead to failed back surgery, the variant described in the present case could lead to iatrogenic injury and complication if not recognized. A unique case of transradicular lumbar disc herniation in a 25-year-old patient is presented with the depiction of intraoperative images supplementing the text.

  18. Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, Sven; Quirbach, Sebastian; Krause, Fabian G.; Benneker, Lorin M. [Inselspital, Berne University Hospital, Department of Orthopaedic Surgery, Berne (Switzerland); Mamisch, Tallal C. [Inselspital, Berne University Hospital, Department of Radiology, Berne (Switzerland); Werlen, Stefan [Clinic Sonnenhof, Department of Radiology, Berne (Switzerland)

    2012-09-15

    To demonstrate the potential benefits of biochemical axial T2* mapping of intervertebral discs (IVDs) regarding the detection and grading of early stages of degenerative disc disease using 1.5-Tesla magnetic resonance imaging (MRI) in a clinical setting. Ninety-three patients suffering from lumbar spine problems were examined using standard MRI protocols including an axial T2* mapping protocol. All discs were classified morphologically and grouped as ''healthy'' or ''abnormal''. Differences between groups were analysed regarding to the specific T2* pattern at different regions of interest (ROIs). Healthy intervertebral discs revealed a distinct cross-sectional T2* value profile: T2* values were significantly lower in the annulus fibrosus compared with the nucleus pulposus (P = 0.01). In abnormal IVDs, T2* values were significantly lower, especially towards the centre of the disc representing the expected decreased water content of the nucleus (P = 0.01). In herniated discs, ROIs within the nucleus pulposus and ROIs covering the annulus fibrosus showed decreased T2* values. Axial T2* mapping is effective to detect early stages of degenerative disc disease. There is a potential benefit of axial T2* mapping as a diagnostic tool, allowing the quantitative assessment of intervertebral disc degeneration. circle Axial T2* mapping effective in detecting early degenerative disc disease. (orig.)

  19. Reproductive performance of lactating dairy cows managed for first service using timed artificial insemination with or without detection of estrus using an activity-monitoring system.

    Science.gov (United States)

    Fricke, P M; Giordano, J O; Valenza, A; Lopes, G; Amundson, M C; Carvalho, P D

    2014-05-01

    Lactating dairy cows (n=1,025) on a commercial dairy farm were randomly assigned at 10 ± 3 d in milk (DIM) to 1 of 3 treatments for submitting cows to first artificial insemination (AI) and were fitted with activity-monitoring tags (Heatime; SCR Engineers Ltd., Netanya, Israel) at 24 ± 3 DIM. Cows (n=339) in treatment 1 were inseminated based on increased activity from the end of the voluntary waiting period (50 DIM) until submission to an Ovsynch protocol; cows without increased activity from 21 to 65 DIM began an Ovsynch protocol at 65 ± 3 DIM, whereas cows without increased activity from 21 to 50 DIM but not from 51 to 79 DIM began an Ovsynch protocol at 79 ± 3 DIM. Cows (n=340) in treatment 2 were inseminated based on activity after the second PGF2α injection of a Presynch-Ovsynch protocol at 50 DIM, and cows without increased activity began an Ovsynch protocol at 65 ± 3 DIM. Cows (n=346) in treatment 3 were monitored for activity after the second PGF2α injection of a Presynch-Ovsynch protocol, but all cows received timed AI (TAI) at 75 ± 3 DIM after completing the Presynch-Ovsynch protocol. The activity-monitoring system detected increased activity in 56, 69, and 70% of cows in treatments 1, 2, and 3, respectively. Treatment-2 cows had the fewest average days to first AI (62.5), treatment-3 cows had the most average days to first AI (74.9), and treatment-1 cows had intermediate average days to first AI (67.4). Treatment-1 and -2 cows in which inseminations occurred as a combination between increased activity and TAI had fewer overall pregnancies per AI (P/AI) 35 d after AI (32% for both treatments) compared with treatment-3 cows, all of which received TAI after completing the Presynch-Ovsynch protocol (40%). Based on survival analysis, although the rate at which cows were inseminated differed among treatments, treatment did not affect the proportion of cows pregnant by 300 DIM. Thus, use of an activity-monitoring system to inseminate cows based on

  20. Stellar Wind Erosion of Protoplanetary Discs

    CERN Document Server

    Schnepf, Neesha R; Romanova, Marina

    2014-01-01

    An analytic model is developed for the erosion of protoplanetary gas discs by high velocity magnetized stellar winds. The winds are centrifugally driven from the surface of rapidly rotating, strongly magnetized young stars. The presence of the magnetic field in the wind leads to Reynolds numbers sufficiently large to cause a strongly turbulent wind/disk boundary layer which entrains and carries away the disc gas. The model uses the conservation of mass and momentum in the turbulent boundary layer. The time-scale for significant erosion depends on the disc accretion speed, accretion rate and on the wind mass loss rate. The time-scale is estimated to be ~2E6 yr. The stellar wind erosion may act in conjunction with photo-evaporation of the discs.

  1. Magnetic Field Amplification via Protostellar Disc Dynamos

    CERN Document Server

    Dyda, Sergei; Ustyugova, Galina V; Koldoba, Alexander V; Wasserman, Ira

    2015-01-01

    We model the generation of a magnetic field in a protostellar disc using an \\alpha-dynamo and perform axisymmetric magnetohydrodynamics (MHD) simulations of a T Tauri star. We find that for small values of the dimensionless dynamo parameter $\\alpha_d$ the poloidal field grows exponentially at a rate ${\\sigma} \\propto {\\Omega}_K \\sqrt{\\alpha_d}$ , before saturating to a value $\\propto \\sqrt{\\alpha_d}$ . The dynamo excites dipole and octupole modes, but quadrupole modes are suppressed, because of the symmetries of the seed field. Initial seed fields too weak to launch MHD outflows are found to grow sufficiently to launch winds with observationally relevant mass fluxes of order $10^{-9} M_{\\odot}/\\rm{yr}$ for T Tauri stars. For large values of $\\alpha_d$ magnetic loops are generated over the entire disc. These quickly come to dominate the disc dynamics and cause the disc to break up due to the magnetic pressure.

  2. Modeling and Thermal Analysis of Disc

    Directory of Open Access Journals (Sweden)

    Brake Praveena S

    2014-10-01

    Full Text Available The disc brake is a device used for slowing or stopping the rotation of the vehicle. Number of times using the brake for vehicle leads to heat generation during braking event, such that disc brake undergoes breakage due to high Temperature. Disc brake model is done by CATIA and analysis is done by using ANSYS workbench. The main purpose of this project is to study the Thermal analysis of the Materials for the Aluminum, Grey Cast Iron, HSS M42, and HSS M2. A comparison between the four materials for the Thermal values and material properties obtained from the Thermal analysis low thermal gradient material is preferred. Hence best suitable design, low thermal gradient material Grey cast iron is preferred for the Disc Brakes for better performance.

  3. Clumps and Axisymmetric Features in Debris Discs

    CERN Document Server

    Jiang, Ing-Guey

    2013-01-01

    This paper studied the structures of debris discs, focusing on the conditions that can form an axisymmetric-looking outer disc from systems with inner clumps. The main conclusion was that as long as the dominated dust grains are smaller than the blowout size, it is easy to form an axisymmetric-looking outer debris disc, which is part of a quasi-steady state of the whole system. This quasi-steady state is established through the balance between grain generations and a continuous out-going grain flow. Assuming there is an event that starts planetesimal collisions and the corresponding grain generations, this balance can be approached in a few thousand years. This result suggested that a quasi-steady-state picture could solve the possible mass budget problem of Vega's outer debris disc.

  4. Spiral shocks and accretion in discs

    Energy Technology Data Exchange (ETDEWEB)

    Spruit, H.C.; Matsuda, T.; Inoue, M.; Sawada, K.

    1987-12-01

    Recent numerical and analytical results on disc-like accretion with shock waves as the only dissipation mechanism are compared. The global properties of the process are similar to those of the viscous (..cap alpha..) disc model, but precise values of the effective ..cap alpha.. value as a function of the accretion rate can be calculated. At low values of the ratio of specific heats (..gamma.. < 1.45) accretion is possible without radiative losses. Such adiabatic accretion can occur in practice at high accretion rates on to low mass objects and may be important in the formation of planets. Following previous authors, it is pointed out that non-axisymmetric perturbations in the outer parts of a disc increase in amplitude as they propagate in and cause spiral shocks more easily in a disc than perturbations originating in the inner parts.

  5. Eclipse Mapping: Astrotomography of Accretion Discs

    CERN Document Server

    Baptista, Raymundo

    2015-01-01

    The Eclipse Mapping Method is an indirect imaging technique that transforms the shape of the eclipse light curve into a map of the surface brightness distribution of the occulted regions. Three decades of application of this technique to the investigation of the structure, the spectrum and the time evolution of accretion discs around white dwarfs in cataclysmic variables have enriched our understanding of these accretion devices with a wealth of details such as (but not limited to) moving heating/cooling waves during outbursts in dwarf novae, tidally-induced spiral shocks of emitting gas with sub-Keplerian velocities, elliptical precessing discs associated to superhumps, and measurements of the radial run of the disc viscosity through the mapping of the disc flickering sources. This chapter reviews the principles of the method, discusses its performance, limitations, useful error propagation procedures, as well as highlights a selection of applications aimed at showing the possible scientific problems that ha...

  6. Genetics Home Reference: intervertebral disc disease

    Science.gov (United States)

    ... Ikegawa S. The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. Annu Rev Genomics Hum ... article on PubMed Central Reviewed : October 2016 Published : March 21, 2017 The resources on this site should ...

  7. [Disc electrophoresis of collagen protein (author's transl)].

    Science.gov (United States)

    Reitmayr, P; Verzár, F

    1975-01-01

    The composition of proteins extracted from tendon collagen is investigated by disc electrophoresis. No qualitative differences can be demonstrated between young and old collagen. The action of formaldehyde and methionine on the tendons has no effect on the electrophoretic picture.

  8. Effects of artificial infection of Litopenaeus vannamei by Micrococcus lysodeikticus and WSSV on the activity of immunity related enzymes.

    Science.gov (United States)

    Sun, Cheng-Bo; Wang, Gang; Chan, Siuming F

    2015-10-01

    In this study, the activities of 5 immunity related enzymes namely acid phosphatase (ACP), alkaline phosphatase (AKP), phenoloxidase (PO), peroxidase (POD) and lysozyme phosphatase (LZM)) of Litopenaeus vannamei after they have been injected with different concentrations of Micrococcus lysodeikticus and the white spot syndrome virus (WSSV) were examined. The cumulative mortality at 0, 24, 48, 72, 96 h was obtained. Copy numbers of WSSV in L. vannamei after a single infection, secondary infection and concurrent infection were measured. Hemolymph samples of M. lysodeikticus and WSSV injected shrimp were collected at 0, 6, 12 24, 48, 72, 78, 84, 96 and 120 h. The results were: (i) The cumulative mortality of L. vannamei increased as the shrimp were infected with higher concentration of the bacteria; (ii) The most sensitive changes of ACP, AKP and LZM were in the 6.2 × 10(5), 6.2 × 10(6), 6.2 × 10(7) cfu/mL M. lysodeikticus group; (iii) ACP but LZM were more sensitive to M. lysodeikticus than WSSV, and AKP, PO and POD is more sensitive to WSSV; (iv) The copies of WSSV in the co-injected group were higher than WSSV-single infection and WSSV-bacteria-secondary infection group at 48 h. The amount of WSSV in L. vannamei of concurrent infection and WSSV-bacteria-secondary infection groups were higher than that of the WSSV-single infection group.

  9. CR TKA UHMWPE wear tested after artificial aging of the vitamin E treated gliding component by simulating daily patient activities.

    Science.gov (United States)

    Schwiesau, Jens; Fritz, Bernhard; Kutzner, Ines; Bergmann, Georg; Grupp, Thomas M

    2014-01-01

    The wear behaviour of total knee arthroplasty (TKA) is dominated by two wear mechanisms: the abrasive wear and the delamination of the gliding components, where the second is strongly linked to aging processes and stress concentration in the material. The addition of vitamin E to the bulk material is a potential way to reduce the aging processes. This study evaluates the wear behaviour and delamination susceptibility of the gliding components of a vitamin E blended, ultra-high molecular weight polyethylene (UHMWPE) cruciate retaining (CR) total knee arthroplasty. Daily activities such as level walking, ascending and descending stairs, bending of the knee, and sitting and rising from a chair were simulated with a data set received from an instrumented knee prosthesis. After 5 million test cycles no structural failure of the gliding components was observed. The wear rate was with 5.62 ± 0.53 mg/million cycles falling within the limit of previous reports for established wear test methods.

  10. CR TKA UHMWPE Wear Tested after Artificial Aging of the Vitamin E Treated Gliding Component by Simulating Daily Patient Activities

    Directory of Open Access Journals (Sweden)

    Jens Schwiesau

    2014-01-01

    Full Text Available The wear behaviour of total knee arthroplasty (TKA is dominated by two wear mechanisms: the abrasive wear and the delamination of the gliding components, where the second is strongly linked to aging processes and stress concentration in the material. The addition of vitamin E to the bulk material is a potential way to reduce the aging processes. This study evaluates the wear behaviour and delamination susceptibility of the gliding components of a vitamin E blended, ultra-high molecular weight polyethylene (UHMWPE cruciate retaining (CR total knee arthroplasty. Daily activities such as level walking, ascending and descending stairs, bending of the knee, and sitting and rising from a chair were simulated with a data set received from an instrumented knee prosthesis. After 5 million test cycles no structural failure of the gliding components was observed. The wear rate was with 5.62±0.53 mg/million cycles falling within the limit of previous reports for established wear test methods.

  11. The Annulus Property of Simple Holomorphic Discs

    CERN Document Server

    Zehmisch, Kai

    2010-01-01

    We show that any simple holomorphic disc admits the annulus property, i.e., each interior point is surrounded by an arbitrary small annulus consisting entirely of injective points. As an application we show that interior singularities of holomorphic discs can be resolved after slight perturbation of the involved almost complex structure. Moreover, for boundary points the analogue notion, the half-annulus property, is introduced and studied in detail.

  12. The annulus property of simple holomorphic discs

    OpenAIRE

    Zehmisch, Kai

    2013-01-01

    We show that any simple holomorphic disc admits the annulus property, i.e., each interior point is surrounded by an arbitrary small annulus consisting entirely of injective points. As an application we show that interior singularities of holomorphic discs can be resolved after slight perturbation of the almost complex structure. Moreover, for boundary points the analogue notion, the half-annulus property, is introduced and studied in detail.

  13. Massive thin accretion discs. Pt. 2; Polarization

    Energy Technology Data Exchange (ETDEWEB)

    Laor, A.; Netzer, H. (Tel Aviv Univ. (Israel)); Piran, T. (Hebrew Univ., Jerusalem (Israel). Racah Inst. of Physics)

    1990-02-15

    Thin accretion discs around massive black holes are believed to produce much of the observed optical-UV emission from AGN. Classical calculations predict that this radiation is highly polarized at large inclination angles, in contrast to observations of quasars and Seyfert galaxies. We have calculated the spectrum and polarization of such discs using an improved radiative transfer method with all the relevant opacity sources, and a full general relativistic treatment of the radiation propagation. (author).

  14. Lyman edges in AGN accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Czerny, B. (Copernicus Astronomical Center, Warsaw (Poland)); Pojmanski, G. (Warsaw Univ. (Poland). Obserwatorium Astronomiczne)

    1990-07-01

    We show that the basic difference in the two principal approaches to predictions of the Lyman edge in an accretion disc lies in the implicit assumption about the density of the radiating gas. Independent from the details, models predict a broad range of the edge sizes, both in absorption and in emission. Observed spectra do not exhibit any strong feature at 912 A but may still be consistent with an accretion disc mechanism if more advanced theory is developed. (author).

  15. Gene expression profile analysis of human intervertebral disc degeneration

    OpenAIRE

    Kai Chen; Dajiang Wu; Xiaodong Zhu; Haijian Ni; Xianzhao Wei; Ningfang Mao; Yang Xie; Yunfei Niu; Ming Li

    2013-01-01

    In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less degenerated discs were identified by significant analysis of microarray. A total of 555 genes were signi...

  16. TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study

    Directory of Open Access Journals (Sweden)

    C. Loreto

    2010-09-01

    Full Text Available To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase 3. TRAIL, its death receptor DR5 and caspase 3 expression were studied by immunohistochemistry in 15 TMJ discs displaced without reduction and in 4 unaffected discs. These apoptosis molecules were detected in the intima and media layers of newly formed vessels affected discs. In conclusion, vessels apoptosis activation in TMJ disc with ID could be regarded as a self-limiting process that try to leads to vessel regression; in this way an inhibition of angiogenic vessels may prove a key strategy in limiting pathological angiogenesis, by cutting off blood supply to tumors, or by reducing harmful inflammation.

  17. The Diversity of Thick Galactic Discs

    CERN Document Server

    Kasparova, Anastasia V; Chilingarian, Igor V; Silchenko, Olga K; Moiseev, Alexey V; Borisov, Svyatoslav B

    2016-01-01

    Although thick stellar discs are detected in nearly all edge-on disc galaxies, their formation scenarios still remain a matter of debate. Due to observational difficulties, there is a lack of information about their stellar populations. Using the Russian 6-m telescope BTA we collected deep spectra of thick discs in three edge-on S0-a disc galaxies located in different environments: NGC4111 in a dense group, NGC4710 in the Virgo cluster, and NGC5422 in a sparse group. We see intermediate age (4-5 Gyr) metal rich ([Fe/H] $\\sim$ -0.2 - 0.0 dex) stellar populations in NGC4111 and NGC4710. On the other hand, NGC5422 does not harbour young stars, its disc is thick and old (10 Gyr), without evidence for a second component, and its $\\alpha$-element abundance suggests a 1.5-2 Gyr long formation epoch implying its formation at high redshift. Our results suggest the diversity of thick disc formation scenarios.

  18. Turbulent drag reduction through oscillating discs

    CERN Document Server

    Wise, Daniel J

    2014-01-01

    The changes of a turbulent channel flow subjected to oscillations of wall flush-mounted rigid discs are studied by means of direct numerical simulations. The Reynolds number is $R_\\tau$=$180$, based on the friction velocity of the stationary-wall case and the half channel height. The primary effect of the wall forcing is the sustained reduction of wall-shear stress, which reaches a maximum of 20%. A parametric study on the disc diameter, maximum tip velocity, and oscillation period is presented, with the aim to identify the optimal parameters which guarantee maximum drag reduction and maximum net energy saving, computed by taking into account the power spent to actuate the discs. This may be positive and reaches 6%. The Rosenblat viscous pump flow is used to predict the power spent for disc motion in the turbulent channel flow and to estimate localized and transient regions over the disc surface subjected to the turbulent regenerative braking effect, for which the wall turbulence exerts work on the discs. The...

  19. Magnetic white dwarfs with debris discs

    CERN Document Server

    Külebi, Baybars; Lorén-Aguilar, Pablo; Isern, Jordi; García-Berro, Enrique

    2013-01-01

    It has long been accepted that a possible mechanism for explaining the existence of magnetic white dwarfs is the merger of a binary white dwarf system, as there are viable mechanisms for producing sustainable magnetic fields within the merger product. However, the lack of rapid rotators in the magnetic white dwarf population has been always considered a problematic issue of this scenario. Smoothed Particle Hydrodynamics simulations show that in mergers in which the two white dwarfs have different masses a disc around the central compact object is formed. If the central object is magnetized it can interact with the disc through its magnetosphere. The torque applied by the disc changes the spin of the star, whereas the transferred angular momentum from the star to the disc determines the properties of the disc. In this work we build a model for the disc evolution under the effect of magnetic accretion, and for the angular momentum evolution of the star, which can be compared with the observations. Our model pre...

  20. The maximum rotation of a galactic disc

    CERN Document Server

    Bottema, R

    1997-01-01

    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously rising rotation curve until the outermost measured radial position. That is why a general relation has been derived, giving the maximum rotation for a disc depending on the luminosity, surface brightness, and colour of the disc. As a physical basis of this relation serves an adopted fixed mass-to-light ratio as a function of colour. That functionality is consistent with results from population synthesis models and its absolute value is determined from the observed stellar velocity dispersions. The derived maximum disc rotation is compared with a number of observed maximum rotations, clearly demonstrating the need for appreciable amounts of dark matter in the disc region and even more so for LSB galaxies. Matters h...

  1. Clumpy Disc and Bulge Formation

    CERN Document Server

    Perez, J; Tissera, P; Michel-Dansac, L

    2013-01-01

    We present a set of hydrodynamical/Nbody controlled simulations of isolated gas rich galaxies that self-consistently include SN feedback and a detailed chemical evolution model, both tested in cosmological simulations. The initial conditions are motivated by the observed star forming galaxies at z ~ 2-3. We find that the presence of a multiphase interstellar media in our models promotes the growth of disc instability favouring the formation of clumps which in general, are not easily disrupted on timescales compared to the migration time. We show that stellar clumps migrate towards the central region and contribute to form a classical-like bulge with a Sersic index, n > 2. Our physically-motivated Supernova feedback has a mild influence on clump survival and evolution, partially limiting the mass growth of clumps as the energy released per Supernova event is increased, with the consequent flattening of the bulge profile. This regulation does not prevent the building of a classical-like bulge even for the most ...

  2. Artificial Intelligence for the Evaluation of Operational Parameters Influencing Nitrification and Nitrifiers in an Activated Sludge Process.

    Science.gov (United States)

    Awolusi, Oluyemi Olatunji; Nasr, Mahmoud; Kumari, Sheena; Bux, Faizal

    2016-07-01

    Nitrification at a full-scale activated sludge plant treating municipal wastewater was monitored over a period of 237 days. A combination of fluorescent in situ hybridization (FISH) and quantitative real-time polymerase chain reaction (qPCR) were used for identifying and quantifying the dominant nitrifiers in the plant. Adaptive neuro-fuzzy inference system (ANFIS), Pearson's correlation coefficient, and quadratic models were employed in evaluating the plant operational conditions that influence the nitrification performance. The ammonia-oxidizing bacteria (AOB) abundance was within the range of 1.55 × 10(8)-1.65 × 10(10) copies L(-1), while Nitrobacter spp. and Nitrospira spp. were 9.32 × 10(9)-1.40 × 10(11) copies L(-1) and 2.39 × 10(9)-3.76 × 10(10) copies L(-1), respectively. Specific nitrification rate (qN) was significantly affected by temperature (r 0.726, p 0.002), hydraulic retention time (HRT) (r -0.651, p 0.009), and ammonia loading rate (ALR) (r 0.571, p 0.026). Additionally, AOB was considerably influenced by HRT (r -0.741, p 0.002) and temperature (r 0.517, p 0.048), while HRT negatively impacted Nitrospira spp. (r -0.627, p 0.012). A quadratic combination of HRT and food-to-microorganism (F/M) ratio also impacted qN (r (2) 0.50), AOB (r (2) 0.61), and Nitrospira spp. (r (2) 0.72), while Nitrobacter spp. was considerably influenced by a polynomial function of F/M ratio and temperature (r (2) 0.49). The study demonstrated that ANFIS could be used as a tool to describe the factors influencing nitrification process at full-scale wastewater treatment plants.

  3. The role of disc self-gravity in circumbinary planet systems - I. Disc structure and evolution

    Science.gov (United States)

    Mutter, Matthew M.; Pierens, Arnaud; Nelson, Richard P.

    2017-03-01

    We present the results of two-dimensional hydrodynamic simulations of self-gravitating circumbinary discs around binaries whose parameters match those of the circumbinary planet-hosting systems Kepler-16, Kepler-34 and Kepler-35. Previous work has shown that non-self-gravitating discs in these systems form an eccentric precessing inner cavity due to tidal truncation by the binary, and planets which form at large radii migrate until stalling at this cavity. Whilst this scenario appears to provide a natural explanation for the observed orbital locations of the circumbinary planets, previous simulations have failed to match the observed planet orbital parameters. The aim of this work is to examine the role of self-gravity in modifying circumbinary disc structure as a function of disc mass, prior to considering the evolution of embedded circumbinary planets. In agreement with previous work, we find that for disc masses between one and five times the minimum mass solar nebula (MMSN), disc self-gravity affects modest changes in the structure and evolution of circumbinary discs. Increasing the disc mass to 10 or 20 MMSN leads to two dramatic changes in disc structure. First, the scale of the inner cavity shrinks substantially, bringing its outer edge closer to the binary. Secondly, in addition to the eccentric inner cavity, additional precessing eccentric ring-like features develop in the outer regions of the discs. If planet formation starts early in the disc lifetime, these changes will have a significant impact on the formation and evolution of planets and precursor material.

  4. The magnetorotational instability in debris-disc gas

    CERN Document Server

    Kral, Quentin

    2016-01-01

    Debris discs are commonly swathed in gas which can be observed in UV, in fine structure lines in FIR, and in resolved maps of CO emission. Carbon and oxygen are overabundant in such gas, but it is severely depleted in hydrogen. As a consequence, its ionisation fraction is remarkably high, suggesting magnetohydrodynamic (MHD) processes may be important. In particular, the gas may be subject to the magnetorotational instability (MRI), and indeed recent modelling of $\\beta$ Pictoris requires an anomalous viscosity to explain the gas's observed radial structure. In this paper we explore the possibility that the MRI is active in debris-disc gas and responsible for the observed mass transport. We find that non-ideal MHD and dust-gas interactions play a subdominant role, and that linear instability is viable at certain radii. However, owing to low gas densities, the outer parts of the disc could be stabilised by a weak ambient magnetic field, though it is difficult to constrain such a field. Even if the MRI is stabi...

  5. Effects of Tobacco Smoking on the Degeneration of the Intervertebral Disc: A Finite Element Study.

    Science.gov (United States)

    Elmasry, Shady; Asfour, Shihab; de Rivero Vaccari, Juan Pablo; Travascio, Francesco

    2015-01-01

    Tobacco smoking is associated with numerous pathological conditions. Compelling experimental evidence associates smoking to the degeneration of the intervertebral disc (IVD). In particular, it has been shown that nicotine down-regulates both the proliferation rate and glycosaminoglycan (GAG) biosynthesis of disc cells. Moreover, tobacco smoking causes the constriction of the vascular network surrounding the IVD, thus reducing the exchange of nutrients and anabolic agents from the blood vessels to the disc. It has been hypothesized that both nicotine presence in the IVD and the reduced solute exchange are responsible for the degeneration of the disc due to tobacco smoking, but their effects on tissue homeostasis have never been quantified. In this study, a previously presented computational model describing the homeostasis of the IVD was deployed to investigate the effects of impaired solute supply and nicotine-mediated down-regulation of cell proliferation and biosynthetic activity on the health of the disc. We found that the nicotine-mediated down-regulation of cell anabolism mostly affected the GAG concentration at the cartilage endplate, reducing it up to 65% of the value attained in normal physiological conditions. In contrast, the reduction of solutes exchange between blood vessels and disc tissue mostly affected the nucleus pulposus, whose cell density and GAG levels were reduced up to 50% of their normal physiological levels. The effectiveness of quitting smoking on the regeneration of a degenerated IVD was also investigated, and showed to have limited benefit on the health of the disc. A cell-based therapy in conjunction with smoke cessation provided significant improvements in disc health, suggesting that, besides quitting smoking, additional treatments should be implemented in the attempt to recover the health of an IVD degenerated by tobacco smoking.

  6. DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Tyler eCash-Padgett

    2013-09-01

    Full Text Available DISC1 was discovered in a Scottish pedigree in which a chromosomal translocation that breaks this gene segregates with psychiatric disorders, mainly depression and schizophrenia. Linkage and association studies in diverse populations support DISC1 as a susceptibility gene to a variety of neuropsychiatric disorders. Many Disc1 mouse models have been generated to study its neuronal functions. These mouse models display variable phenotypes, some of them relevant to schizophrenia, others to depression.The Disc1 mouse models are popular genetic models for studying gene-environment interactions in schizophrenia. Five different Disc1 models have been combined with environmental factors. The environmental stressors employed can be classified as either early immune activation or later social paradigms. These studies cover major time points along the neurodevelopmental trajectory: prenatal, early postnatal, adolescence, and adulthood. Various combinations of molecular, anatomical and behavioral methods have been used to assess the outcomes. Additionally, three of the studies sought to rescue the resulting abnormalities.Here we provide background on the environmental paradigms used, summarize the results of these studies combining Disc1 mouse models with environmental stressors and discuss what we can learn and how to proceed. A major question is how the genetic and environmental factors determine which psychiatric disorder will be clinically manifested. To address this we can take advantage of the many Disc1 models available and expose them to the same environmental stressor. The complementary experiment would be to expose the same model to different environmental stressors. DISC1 is an ideal gene for this approach, since in the Scottish pedigree the same chromosomal translocation results in different psychiatric conditions.

  7. A two-fluid model for black-hole accretion flows: particle acceleration and disc structure

    Science.gov (United States)

    Lee, Jason P.; Becker, Peter A.

    2017-02-01

    Hot, tenuous advection-dominated accretion flows around black holes are ideal sites for the Fermi acceleration of relativistic particles at standing shock waves in the accretion disc. Previous work has demonstrated that the shock-acceleration process can be efficient enough to power the observed, strong outflows in radio-loud active galaxies such as M87. However, the dynamical effect (back-reaction) on the flow, exerted by the pressure of the relativistic particles, has not been previously considered, and this effect can have a significant influence on the disc structure. We reexamine the problem by developing a new, two-fluid model for the structure of the accretion disc that includes the dynamical effect of the relativistic particle pressure, combined with the pressure of the background (thermal) gas. The new model is analogous to the two-fluid model of cosmic ray acceleration in supernova-driven shock waves. As part of the model, we also develop a new set of shock jump conditions, which are solved along with the hydrodynamic conservation equations to determine the structure of the accretion disc. The solutions include the formation of a mildly relativistic outflow (jet) at the shock radius, driven by the relativistic particles accelerated in the disc. One of our main conclusions is that in the context of the new two-fluid accretion model, global smooth (shock-free) solutions do not exist, and the disc must always contain a standing shock wave, at least in the inviscid case considered here.

  8. Effect of Gas Accretion Disc Profile on Orbital Parameters of the Accreted Stars

    Science.gov (United States)

    Shukirgaliyev, Bekdaulet T.; Panamarev, Taras P.; Naurzbaeva, Aisha Zh.; Kalambay, Mukhagali T.; Makukov, Maxim A.; Vilkoviskij, Emmanuil Y.; Omarov, Chingis T.; Berczik, Peter; Just, Andreas; Spurzem, Rainer

    2016-10-01

    The results of studies of the effect of the gas disk and its profile on the dynamics of active galactic nuclei are presented. The study was conducted with a numerical model of galactic nucleus based on phiGRAPE+GPU comprising three subsystems - a central supermassive black hole, gaseous accretion disc, and compact stellar cluster. The evolution of the compact stellar cluster is modeled with direct integration (N-body simulation), while the black hole and gaseous disc are represented phenomenologically: the black hole is introduced as an external potential (fixed in space but variable in time due to black hole mass growth), and the gaseous disc is introduced as spatial time-independent density distribution. We examined and compared with each other orbital parameters of accreting stars for model of the galactic nucleus with gas disc of constant and variable thickness, as well as without gas. It was found that in the presence of a gaseous disk almost half of the accreted particles interact strongly with the gas and are captured by the disc before accretion, while more than 85% of particles are affected to some extent by the disc prior to accretion. This suggests that interaction of the stellar cluster with the gas disk in the galactic nucleus might lead to the formation of stellar disk in the central part of the nucleus.

  9. Liberation of specific angular momentum through radiation and scattering in relativistic black hole accretion discs

    CERN Document Server

    Stevens, Adam R H

    2015-01-01

    A key component of explaining the array of galaxies observed in the Universe is the feedback of active galactic nuclei, each powered by a massive black hole's accretion disc. For accretion to occur, angular momentum must be lost by that which is accreted. Electromagnetic radiation must offer some respite in this regard, the contribution for which is quantified in this paper using solely general relativity under the thin-disc regime. Herein, I calculate extremised situations where photons are entirely responsible for energy removal in the disc and then extend and relate this to the standard relativistic accretion disc outlined by Novikov & Thorne that includes the effect of viscosity. While there is potential for the contribution of angular-momentum removal from photons to be >~1% out to ~10^4 Schwarzschild radii, especially if the disc is irradiated and is liberated of angular momentum through scattering, it is more likely of order 10^2 Schwarzschild radii if thermal emission from the disc itself is stron...

  10. Electron-Positron Outflows from $\\gamma$-Ray Emitting Accretion Discs

    CERN Document Server

    Beloborodov, A M

    1999-01-01

    An electron-positron atmosphere is inevitably created around a black hole accretion disc whose spectrum extends to MeV energies. Pairs created in photon-photon collisions outside the disc are blown away by soft radiation (which dominates the bolometric luminosity of the disc) and form a semi-relativistic outflow. We simulate numerically the conversion of the MeV radiation into a vertical e+- outflow above a disc-like source. The outflowing e+- plasma becomes optically thick to Thomson scattering if the compactness of the gamma-ray source exceeds 30. The scattering by e+- then collimates the bulk of soft radiation along the disc axis, and the apparent bolometric luminosity of the disc depends strongly on its inclination to the line of sight. The anisotropic central emission may account for the lack of Fe K-alpha lines in the X-ray spectra of bright radio-quiet quasars. The scattering in e+- outflows may also explain the orientation of optical polarization in non-blazar active galactic nuclei.

  11. Planetesimal formation in self-gravitating discs -- dust trapping by vortices

    CERN Document Server

    Gibbons, P G; Rice, W K M

    2015-01-01

    The mechanism through which meter-sized boulders grow to km-sized planetesimals in protoplanetary discs is a subject of active research, since it is critical for planet formation. To avoid spiralling into the protostar due to aerodynamic drag, objects must rapidly grow from cm-sized pebbles, which are tightly coupled to the gas, to large boulders of 1-100m in diameter. It is already well known that over-densities in the gaseous component of the disc provide potential sites for the collection of solids, and that significant density structures in the gaseous component of the disc (e.g., spiral density waves) can trap solids efficiently enough for the solid component of the disc to undergo further gravitational collapse due to their own self-gravity. In this work, we employ the PENCIL CODE to conduct local shearing sheet simulations of massive self-gravitating protoplanetary discs, to study the effect of anticyclonic transient vortices, or eddies, on the evolution of solids in these discs. We find that these typ...

  12. Effects of supernova feedback on the formation of galaxy discs

    Science.gov (United States)

    Scannapieco, Cecilia; Tissera, Patricia B.; White, Simon D. M.; Springel, Volker

    2008-09-01

    We use cosmological simulations in order to study the effects of supernova (SN) feedback on the formation of a Milky Way-type galaxy of virial mass ~1012h-1Msolar. We analyse a set of simulations run with the code described by Scannapieco et al., where we have tested our star formation and feedback prescription using isolated galaxy models. Here, we extend this work by simulating the formation of a galaxy in its proper cosmological framework, focusing on the ability of the model to form a disc-like structure in rotational support. We find that SN feedback plays a fundamental role in the evolution of the simulated galaxy, efficiently regulating the star-formation activity, pressurizing the gas and generating mass-loaded galactic winds. These processes affect several galactic properties such as final stellar mass, morphology, angular momentum, chemical properties, and final gas and baryon fractions. In particular, we find that our model is able to reproduce extended disc components with high specific angular momentum and a significant fraction of young stars. The galaxies are also found to have significant spheroids composed almost entirely of stars formed at early times. We find that most combinations of the input parameters yield disc-like components, although with different sizes and thicknesses, indicating that the code can form discs without fine-tuning the implemented physics. We also show how our model scales to smaller systems. By analysing simulations of virial masses 109 and 1010h-1Msolar, we find that the smaller the galaxy, the stronger the SN feedback effects.

  13. Artificial neural network and particle swarm optimization for removal of methyl orange by gold nanoparticles loaded on activated carbon and Tamarisk

    Science.gov (United States)

    Ghaedi, M.; Ghaedi, A. M.; Ansari, A.; Mohammadi, F.; Vafaei, A.

    2014-11-01

    The influence of variables, namely initial dye concentration, adsorbent dosage (g), stirrer speed (rpm) and contact time (min) on the removal of methyl orange (MO) by gold nanoparticles loaded on activated carbon (Au-NP-AC) and Tamarisk were investigated using multiple linear regression (MLR) and artificial neural network (ANN) and the variables were optimized by partial swarm optimization (PSO). Comparison of the results achieved using proposed models, showed the ANN model was better than the MLR model for prediction of methyl orange removal using Au-NP-AC and Tamarisk. Using the optimal ANN model the coefficient of determination (R2) for the test data set were 0.958 and 0.989; mean squared error (MSE) values were 0.00082 and 0.0006 for Au-NP-AC and Tamarisk adsorbent, respectively. In this study a novel and green approach were reported for the synthesis of gold nanoparticle and activated carbon by Tamarisk. This material was characterized using different techniques such as SEM, TEM, XRD and BET. The usability of Au-NP-AC and activated carbon (AC) Tamarisk for the methyl orange from aqueous solutions was investigated. The effect of variables such as pH, initial dye concentration, adsorbent dosage (g) and contact time (min) on methyl orange removal were studied. Fitting the experimental equilibrium data to various isotherm models such as Langmuir, Freundlich, Tempkin and Dubinin-Radushkevich models show the suitability and applicability of the Langmuir model. Kinetic models such as pseudo-first order, pseudo-second order, Elovich and intraparticle diffusion models indicate that the second-order equation and intraparticle diffusion models control the kinetic of the adsorption process. The small amount of proposed Au-NP-AC and activated carbon (0.015 g and 0.75 g) is applicable for successful removal of methyl orange (>98%) in short time (20 min for Au-NP-AC and 45 min for Tamarisk-AC) with high adsorption capacity 161 mg g-1 for Au-NP-AC and 3.84 mg g-1 for Tamarisk-AC.

  14. Artificial neural network and particle swarm optimization for removal of methyl orange by gold nanoparticles loaded on activated carbon and Tamarisk.

    Science.gov (United States)

    Ghaedi, M; Ghaedi, A M; Ansari, A; Mohammadi, F; Vafaei, A

    2014-11-11

    The influence of variables, namely initial dye concentration, adsorbent dosage (g), stirrer speed (rpm) and contact time (min) on the removal of methyl orange (MO) by gold nanoparticles loaded on activated carbon (Au-NP-AC) and Tamarisk were investigated using multiple linear regression (MLR) and artificial neural network (ANN) and the variables were optimized by partial swarm optimization (PSO). Comparison of the results achieved using proposed models, showed the ANN model was better than the MLR model for prediction of methyl orange removal using Au-NP-AC and Tamarisk. Using the optimal ANN model the coefficient of determination (R2) for the test data set were 0.958 and 0.989; mean squared error (MSE) values were 0.00082 and 0.0006 for Au-NP-AC and Tamarisk adsorbent, respectively. In this study a novel and green approach were reported for the synthesis of gold nanoparticle and activated carbon by Tamarisk. This material was characterized using different techniques such as SEM, TEM, XRD and BET. The usability of Au-NP-AC and activated carbon (AC) Tamarisk for the methyl orange from aqueous solutions was investigated. The effect of variables such as pH, initial dye concentration, adsorbent dosage (g) and contact time (min) on methyl orange removal were studied. Fitting the experimental equilibrium data to various isotherm models such as Langmuir, Freundlich, Tempkin and Dubinin-Radushkevich models show the suitability and applicability of the Langmuir model. Kinetic models such as pseudo-first order, pseudo-second order, Elovich and intraparticle diffusion models indicate that the second-order equation and intraparticle diffusion models control the kinetic of the adsorption process. The small amount of proposed Au-NP-AC and activated carbon (0.015 g and 0.75 g) is applicable for successful removal of methyl orange (>98%) in short time (20 min for Au-NP-AC and 45 min for Tamarisk-AC) with high adsorption capacity 161 mg g(-1) for Au-NP-AC and 3.84 mg g(-1) for

  15. Artificial cognition architectures

    CERN Document Server

    Crowder, James A; Friess, Shelli A

    2013-01-01

    The goal of this book is to establish the foundation, principles, theory, and concepts that are the backbone of real, autonomous Artificial Intelligence. Presented here are some basic human intelligence concepts framed for Artificial Intelligence systems. These include concepts like Metacognition and Metamemory, along with architectural constructs for Artificial Intelligence versions of human brain functions like the prefrontal cortex. Also presented are possible hardware and software architectures that lend themselves to learning, reasoning, and self-evolution

  16. A Simulation Model of Focus and Radial Servos in Compact Disc Players with Disc Surface Defects

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Andersen, Palle;

    2004-01-01

    Compact Disc players have been on the market in more than two decades.As a consequence most of the control servo problems have been solved. A large remaining problem to solve is the handling of Compact Discs with severe surface defects like scratches and fingerprints. This paper introduces a method...

  17. Evolution from protoplanetary to debris discs: The transition disc around HD 166191

    CERN Document Server

    Kennedy, G M; Lisse, C M; Ménard, F; Sitko, M L; Wyatt, M C; Bayliss, D D R; DeMeo, F E; Crawford, K B; Kim, D L; Rudy, R J; Russell, R W; Sibthorpe, B; Skinner, M A; Zhou, G

    2013-01-01

    HD 166191 has been identified by several studies as hosting a rare and extremely bright warm debris disc with an additional outer cool disc component. However, an alternative interpretation is that the star hosts a disc that is currently in transition between a full gas disc and a largely gas-free debris disc. With the help of new optical to mid-IR spectra and Herschel imaging, we argue that the latter interpretation is supported in several ways: i) we show that HD 166191 is co-moving with the ~4 Myr-old Herbig Ae star HD 163296, suggesting that the two have the same age, ii) the disc spectrum of HD 166191 is well matched by a standard radiative transfer model of a gaseous protoplanetary disc with an inner hole, and iii) the HD 166191 mid-IR silicate feature is more consistent with similarly primordial objects. We note some potential issues with the debris disc interpretation that should be considered for such extreme objects, whose lifetime at the current brightness is mush shorter than the stellar age, or i...

  18. Poroelastic behaviour of the degenerating human intervertebral disc: a ten-day study in a loaded disc culture system

    Directory of Open Access Journals (Sweden)

    KS Emanuel

    2015-06-01

    Full Text Available The intervertebral disc (IVD allows flexibility to the vertebral column, and transfers the predominant axial loads during daily activities. Its axial biomechanical behaviour is poroelastic, due to the water-binding and releasing capacity of the nucleus pulposus. Degeneration of the intervertebral disc presumably affects both the instantaneous elastic response to the load on the IVD and the subsequent interstitial flow of fluid. This study aims to quantify the poroelastic behaviour of the IVD and its change with degeneration, as defined by the magnetic resonance imaging-based Pfirrmann Score (PS. For a period of ten days, 36 human lumbar IVDs were loaded with a simulated physiological axial loading regime, while deformation was monitored. The IVDs responded to the loads with instantaneous elastic and slow poroelastic axial deformation. Several mechanical parameters changed throughout the first five days of the experiment, until the IVDs settled into a dynamic equilibrium. In this equilibrium, degeneration was significantly related to a decrease in disc height loss during the daytime high load phase (ρ = -0.49, and to a decrease in the rate of this deformation during the final half hour of each day (ρ = -0.53. These properties were related to the nucleus glycosaminoglycan/hydroxyproline (GAG/HYP ratio, rather than GAG content alone, indicating that remodelling of the extracellular matrix reduces poroelastic properties of the IVD. This implies that the degenerated discs have a reduced capacity to bind water and/or a reduced resistance against fluid flow. The resulting loss in hydrostatic pressure may further change cell behaviour in the nucleus pulposus.

  19. Stem cell horizons in intervertebral disc degeneration

    Directory of Open Access Journals (Sweden)

    Joseph Ciacci

    2009-01-01

    Full Text Available Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and spine. The growing field of regenerative medicine brings the promise of stem cells in the treatment of disc disease. Scientists and physicians hope to employ stem cells not only to stop, but also reverse degeneration. However, there are many important outstanding issues, including the hostile avascular, apoptotic physiological environment of the intervertebral disc, and the difficulty of obtaining mesenchymal stem cells, and directing them towards chondrocytic differentiation and integration within the nucleus pulposus of the disc. Given the recent advances in minimally invasive spine surgery, and developing body of work on stem cell manipulation and transplantation, stem cells are uniquely poised to bring about large-scale improvements in treatment and outcomes for degenerative disc disease. In this review we will first discuss the cellular and molecular factors influencing degeneration, and then examine the efficacy and difficulties of stem cell transplantation.Keywords: intervertebral disc degeneration, stem cells, disc disease, mesenchymal stem cells, stem cell transplantation

  20. Cervical disc hernia operations through posterior laminoforaminotomy

    Directory of Open Access Journals (Sweden)

    Coskun Yolas

    2016-01-01

    Full Text Available Objective: The most common used technique for posterolateral cervical disc herniations is anterior approach. However, posterior cervical laminotoforaminomy can provide excellent results in appropriately selected patients with foraminal stenosis in either soft disc prolapse or cervical spondylosis. The purpose of this study was to present the clinical outcomes following posterior laminoforaminotomy in patients with radiculopathy. Materials and Methods: We retrospectively evaluated 35 patients diagnosed with posterolateral cervical disc herniation and cervical spondylosis with foraminal stenosis causing radiculopathy operated by the posterior cervical keyhole laminoforaminotomy between the years 2010 and 2015. Results: The file records and the radiographic images of the 35 patients were assessed retrospectively. The mean age was 46.4 years (range: 34-66 years. Of the patients, 19 were males and 16 were females. In all of the patients, the neurologic deficit observed was radiculopathy. The posterolaterally localized disc herniations and the osteophytic structures were on the left side in 18 cases and on the right in 17 cases. In 10 of the patients, the disc level was at C5-6, in 18 at C6-7, in 2 at C3-4, in 2 at C4-5, in 1 at C7-T1, in 1 patient at both C5-6 and C6-7, and in 1 at both C4-5 and C5-6. In 14 of these 35 patients, both osteophytic structures and protruded disc herniation were present. Intervertebral foramen stenosis was present in all of the patients with osteophytes. Postoperatively, in 31 patients the complaints were relieved completely and four patients had complaints of neck pain and paresthesia radiating to the arm (the success of operation was 88.5%. On control examinations, there was no finding of instability or cervical kyphosis. Conclusion: Posterior cervical laminoforaminotomy is an alternative appropriate choice in both cervical soft disc herniations and cervical stenosis.

  1. Reproductive performance of dairy cows managed with a program aimed at increasing insemination of cows in estrus based on increased physical activity and fertility of timed artificial inseminations.

    Science.gov (United States)

    Giordano, J O; Stangaferro, M L; Wijma, R; Chandler, W C; Watters, R D

    2015-04-01

    The objective of this study was to compare the reproductive performance of lactating dairy cows using a treatment (TRT) program for second and subsequent artificial insemination (AI) services aimed at (1) increasing AI upon estrus detection based on increased physical activity (AIAct) and (2) increasing fertility of timed AI (TAI) services for cows not AIAct through presynchronization of the estrous cycle and improved physiological milieu before TAI. Cows in the control (CON) group were managed with a program that combined AIAct and TAI after the Ovsynch protocol. After nonpregnancy diagnosis (NPD) by transrectal ultrasonography at 31 ± 3 d after AI, cows received the following treatments: (1) CON (n=634), AIAct any time after a previous AI and resynchronization with the Ovsynch-56 protocol (GnRH-7d-PGF2α-56 h-GnRH-16 h-TAI) 1d after NPD, or (2) TRT (n = 616): cows with a corpus luteum (CL) ≥ 20 mm (TRT-CL) received a PGF2α injection 1d after NPD, whereas cows with no CL or a CL insemination after NPD were greater for cows in the TRT (17 d) than the CON (10 d) group, which coupled with similar fertility to AIAct, and TAI failed to improve overall reproductive performance. A low proportion of cows with a CL at NPD (65.2%) and a poor response to PGF2α may explain the poor estrus detection efficiency in the TRT group. We concluded that, when compared with a typical estrus detection and TAI program for cows failing to conceive to previous AI services, a program aimed at increasing the proportion of cows AIAct after NPD and fertility of TAI services increased the proportion of cows AIAct but failed to reduce days to pregnancy during lactation because of greater days to AI after NPD.

  2. Isotherm and kinetics study of malachite green adsorption onto copper nanowires loaded on activated carbon: Artificial neural network modeling and genetic algorithm optimization

    Science.gov (United States)

    Ghaedi, M.; Shojaeipour, E.; Ghaedi, A. M.; Sahraei, Reza

    2015-05-01

    In this study, copper nanowires loaded on activated carbon (Cu-NWs-AC) was used as novel efficient adsorbent for the removal of malachite green (MG) from aqueous solution. This new material was synthesized through simple protocol and its surface properties such as surface area, pore volume and functional groups were characterized with different techniques such XRD, BET and FESEM analysis. The relation between removal percentages with variables such as solution pH, adsorbent dosage (0.005, 0.01, 0.015, 0.02 and 0.1 g), contact time (1-40 min) and initial MG concentration (5, 10, 20, 70 and 100 mg/L) was investigated and optimized. A three-layer artificial neural network (ANN) model was utilized to predict the malachite green dye removal (%) by Cu-NWs-AC following conduction of 248 experiments. When the training of the ANN was performed, the parameters of ANN model were as follows: linear transfer function (purelin) at output layer, Levenberg-Marquardt algorithm (LMA), and a tangent sigmoid transfer function (tansig) at the hidden layer with 11 neurons. The minimum mean squared error (MSE) of 0.0017 and coefficient of determination (R2) of 0.9658 were found for prediction and modeling of dye removal using testing data set. A good agreement between experimental data and predicted data using the ANN model was obtained. Fitting the experimental data on previously optimized condition confirm the suitability of Langmuir isotherm models for their explanation with maximum adsorption capacity of 434.8 mg/g at 25 °C. Kinetic studies at various adsorbent mass and initial MG concentration show that the MG maximum removal percentage was achieved within 20 min. The adsorption of MG follows the pseudo-second-order with a combination of intraparticle diffusion model.

  3. Artificial neural network (ANN) method for modeling of sunset yellow dye adsorption using zinc oxide nanorods loaded on activated carbon: Kinetic and isotherm study.

    Science.gov (United States)

    Maghsoudi, M; Ghaedi, M; Zinali, A; Ghaedi, A M; Habibi, M H

    2015-01-05

    In this research, ZnO nanoparticle loaded on activated carbon (ZnO-NPs-AC) was synthesized simply by a low cost and nontoxic procedure. The characterization and identification have been completed by different techniques such as SEM and XRD analysis. A three layer artificial neural network (ANN) model is applicable for accurate prediction of dye removal percentage from aqueous solution by ZnO-NRs-AC following conduction of 270 experimental data. The network was trained using the obtained experimental data at optimum pH with different ZnO-NRs-AC amount (0.005-0.015 g) and 5-40 mg/L of sunset yellow dye over contact time of 0.5-30 min. The ANN model was applied for prediction of the removal percentage of present systems with Levenberg-Marquardt algorithm (LMA), a linear transfer function (purelin) at output layer and a tangent sigmoid transfer function (tansig) in the hidden layer with 6 neurons. The minimum mean squared error (MSE) of 0.0008 and coefficient of determination (R(2)) of 0.998 were found for prediction and modeling of SY removal. The influence of parameters including adsorbent amount, initial dye concentration, pH and contact time on sunset yellow (SY) removal percentage were investigated and optimal experimental conditions were ascertained. Optimal conditions were set as follows: pH, 2.0; 10 min contact time; an adsorbent dose of 0.015 g. Equilibrium data fitted truly with the Langmuir model with maximum adsorption capacity of 142.85 mg/g for 0.005 g adsorbent. The adsorption of sunset yellow followed the pseudo-second-order rate equation.

  4. Rigid Organization of Fluorescence-Active Ligands by Artificial Macrocyclic Receptor to Achieve the Thioflavin T-Amyloid Fibril Level Association.

    Science.gov (United States)

    Zhang, Ying-Ming; Zhang, Xu-Jie; Xu, Xiufang; Fu, Xiao-Ning; Hou, Hong-Biao; Liu, Yu

    2016-04-28

    The push-pull molecules with an intramolecular charge transfer from donor to acceptor sides upon excitation exhibit a wide variety of biological and electronic activities, as exemplified by the in vivo fluorescence imaging probes for amyloid fibrils in the diagnosis and treatment of amyloid diseases. Interestingly, the structurally much simpler bis(4,8-disulfonato-1,5-naphtho)-32-crown-8 (DNC), in keen contrast to the conventional macrocyclic receptors, was found to dramatically enhance the fluorescence of twisted intramolecular charge-transfer molecules possessing various benzothiazolium and stilbazolium fluorophores upon complexation. Spectroscopic and microcalorimetric titrations jointly demonstrated the complex structures and the interactions that promote the extremely strong complexation, revealing that the binding affinity in these artificial host-guest pairs could reach up to a nearly 10(7) M(-1) order of magnitude in water, and the sandwich-type complexation is driven by electrostatic, hydrophobic, π-stacking, and hydrogen-bonding interactions. Quantum chemical calculations on free molecules and their DNC-bound species in both the ground and excited states elucidated that the encapsulation by DNC could greatly deter the central single and double chemical bonds from free intramolecular rotation in the singlet excited state, thus leading to the unique and unprecedented fluorescence enhancement upon sandwich-type complexation. This complexation-induced structural reorganization mechanism may also apply to the binding of other small-molecule ligands by functional receptors and contribute to the molecular-level understanding of the receptor-ligand interactions in many biology-related systems.

  5. A quantitative structure–activity relationship study on HIV-1 integrase inhibitors using genetic algorithm, artificial neural networks and different statistical methods

    Directory of Open Access Journals (Sweden)

    Ghasem Ghasemi

    2016-09-01

    Full Text Available In this work, quantitative structure–activity relationship (QSAR study has been done on tricyclic phthalimide analogues acting as HIV-1 integrase inhibitors. Forty compounds were used in this study. Genetic algorithm (GA, artificial neural network (ANN and multiple linear regressions (MLR were utilized to construct the non-linear and linear QSAR models. It revealed that the GA–ANN model was much better than other models. For this purpose, ab initio geometry optimization performed at B3LYP level with a known basis set 6–31G (d. Hyperchem, ChemOffice and Gaussian 98W softwares were used for geometry optimization of the molecules and calculation of the quantum chemical descriptors. To include some of the correlation energy, the calculation was done with the density functional theory (DFT with the same basis set and Becke’s three parameter hybrid functional using the LYP correlation functional (B3LYP/6–31G (d. For the calculations in solution phase, the polarized continuum model (PCM was used and also included optimizations at gas-phase B3LYP/6–31G (d level for comparison. In the aqueous phase, the root–mean–square errors of the training set and the test set for GA–ANN model using jack–knife method, were 0.1409, 0.1804, respectively. In the gas phase, the root–mean–square errors of the training set and the test set for GA–ANN model were 0.1408, 0.3103, respectively. Also, the R2 values in the aqueous and the gas phase were obtained as 0.91, 0.82, respectively.

  6. The inner cavity of the circumnuclear disc

    CERN Document Server

    Blank, Marvin; Frank, Adam; Carroll-Nellenback, Jonathan J; Duschl, Wolfgang J

    2016-01-01

    The circumnuclear disc (CND) orbiting the Galaxy's central black hole is a reservoir of material that can ultimately provide energy through accretion, or form stars in the presence of the black hole, as evidenced by the stellar cluster that is presently located at the CND's centre. In this paper, we report the results of a computational study of the dynamics of the CND. The results lead us to question two paradigms that are prevalent in previous research on the Galactic Centre. The first is that the disc's inner cavity is maintained by the interaction of the central stellar cluster's strong winds with the disc's inner rim, and second, that the presence of unstable clumps in the disc implies that the CND is a transient feature. Our simulations show that, in the absence of a magnetic field, the interaction of the wind with the inner disc rim actually leads to a filling of the inner cavity within a few orbital time-scales, contrary to previous expectations. However, including the effects of magnetic fields stabi...

  7. Structures induced by companions in galactic discs

    CERN Document Server

    Kyziropoulos, P; Gravvanis, G; Patsis, P

    2016-01-01

    Using N-body simulations we study the structures induced on a galactic disc by repeated flybys of a companion in decaying eccentric orbit around the disc. Our system is composed by a stellar disc, bulge and live dark matter halo, and we study the system's dynamical response to a sequence of a companion's flybys, when we vary i) the disc's temperature (parameterized by Toomre's Q-parameter) and ii) the companion's mass and initial orbit. We use a new 3D Cartesian grid code: MAIN (Mesh-adaptive Approximate Inverse N-body solver). The main features of MAIN are reviewed, with emphasis on the use of a new Symmetric Factored Approximate Sparse Inverse (SFASI) matrix in conjunction with the multigrid method that allows the efficient solution of Poisson's equation in three space variables. We find that: i) companions need to be assigned initial masses in a rather narrow window of values in order to produce significant and more long-standing non-axisymmetric structures (bars and spirals) in the main galaxy's disc by t...

  8. Lubrication regimes in lumbar total disc arthroplasty.

    Science.gov (United States)

    Shaheen, A; Shepherd, D E T

    2007-08-01

    A number of total disc arthroplasty devices have been developed. Some concern has been expressed that wear may be a potential failure mode for these devices, as has been seen with hip arthroplasty. The aim of this paper was to investigate the lubrication regimes that occur in lumbar total disc arthroplasty devices. The disc arthroplasty was modelled as a ball-and-socket joint. Elastohydrodynamic lubrication theory was used to calculate the minimum film thickness of the fluid between the bearing surfaces. The lubrication regime was then determined for different material combinations, size of implant, and trunk velocity. Disc arthroplasties with a metal-polymer or metal-metal material combination operate with a boundary lubrication regime. A ceramic-ceramic material combination has the potential to operate with fluid-film lubrication. Disc arthroplasties with a metal-polymer or metal-metal material combination are likely to generate wear debris. In future, it is worth considering a ceramic-ceramic material combination as this is likely to reduce wear.

  9. The quiescent phase of galactic disc growth

    CERN Document Server

    Aumer, Michael; Schönrich, Ralph

    2016-01-01

    We perform a series of controlled N-body simulations of growing disc galaxies within non-growing, live dark matter haloes of varying mass and concentration. Our initial conditions include either a low-mass disc or a compact bulge. New stellar particles are continuously added on near-circular orbits to the existing disc, so spiral structure is continuously excited. To study the effect of combined spiral and giant molecular cloud (GMC) heating on the discs we introduce massive, short-lived particles that sample a GMC mass function. An isothermal gas component is introduced for a subset of the models. We perform a resolution study and vary parameters governing the GMC population, the histories of star formation and radial scale growth. Models with GMCs and standard values for the disc mass and halo density provide the right level of self-gravity to explain the age velocity dispersion relation of the Solar neighbourhood (Snhd). GMC heating generates remarkably exponential vertical profiles with scaleheights that ...

  10. Dynamical instabilities in disc-planet interactions

    CERN Document Server

    Lin, Min-Kai

    2012-01-01

    Protoplanetary discs may become dynamically unstable due to structure induced by an embedded giant planet. In this thesis, I discuss the stability of such systems and explore the consequence of instability on planetary migration. I begin with non-self-gravitating, low viscosity discs and show that giant planets induce shocks inside its co-orbital region, leading to a profile unstable to vortex formation around a potential vorticity minimum. This instability is commonly known as the vortex or Rossby wave instability. Vortex-planet interaction lead to episodic phases of migration, which can be understood in the framework of type III migration. I then examine the effect of disc self-gravity on gap stability. The linear theory of the Rossby wave instability is extended to include disc gravity, which shows that self-gravity is effective at stabilising the vortex instability at small azimuthal wavenumber. This is consistent with the observation that more vortices develop with increasing disc mass in hydrodynamic si...

  11. Artificial life and life artificialization in Tron

    Directory of Open Access Journals (Sweden)

    Carolina Dantas Figueiredo

    2012-12-01

    Full Text Available Cinema constantly shows the struggle between the men and artificial intelligences. Fiction, and more specifically fiction films, lends itself to explore possibilities asking “what if?”. “What if”, in this case, is related to the eventual rebellion of artificial intelligences, theme explored in the movies Tron (1982 and Tron Legacy (2010 trat portray the conflict between programs and users. The present paper examines these films, observing particularly the possibility programs empowering. Finally, is briefly mentioned the concept of cyborg as a possibility of response to human concerns.

  12. Disc degeneration and chronic low back pain: an association which becomes nonsignificant when endplate changes and disc contour are taken into account

    Energy Technology Data Exchange (ETDEWEB)

    Kovacs, Francisco M. [Fundacion Kovacs, Departamento Cientifico, Palma de Mallorca (Spain); Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Arana, Estanislao [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Fundacion Instituto Valenciano de Oncologia, Servicio de Radiologia, Valencia (Spain); Royuela, Ana [CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid (Spain); Hospital Ramon y Cajal, Unidad de Bioestadistica Clinica, IRYCIS, Madrid (Spain); Estremera, Ana; Amengual, Guillermo; Sarasibar, Helena; Martinez, Carmen [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Hospital Son Llatzer, Palma de Mallorca (Spain); Asenjo, Beatriz [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Hospital Carlos Haya, Malaga (Spain); Galarraga, Isabel [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Hospital de Manacor, Manacor, Mallorca (Spain); Alonso, Ana [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Fundacion Jimenez Diaz, Madrid (Spain); Casillas, Carlos [Fundacion Kovacs, Spanish Back Pain Research Network, Palma de Mallorca (Spain); Instituto de Traumatologia Union de Mutuas, Castellon (Spain); Muriel, Alfonso; Abraira, Victor [Hospital Ramon y Cajal, Unidad de Bioestadistica Clinica, IRYCIS, Madrid (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid (Spain)

    2014-01-15

    The objective of this study was to assess the association between severe disc degeneration (DD) and low back pain (LBP). A case-control study was conducted with 304 subjects, aged 35-50, recruited in routine clinical practice across six hospitals; 240 cases (chronic LBP patients with a median pain duration of 46 months) and 64 controls (asymptomatic subjects without any lifetime history of significant LBP). The following variables were assessed once, using previously validated methods: gender, age, body mass index (BMI), lifetime smoking exposure, degree of physical activity, severity of LBP, disabi