WorldWideScience

Sample records for artery intima-media thickness

  1. Ultrasound evaluation of intima media thickness of carotid arteries in dialysis patients and correlation with proposed risk factors

    Directory of Open Access Journals (Sweden)

    Damjanović Tatjana

    2003-01-01

    Full Text Available Atherosclerosis is significant risk factor for cardiovascular morbidity and mortality in dialysis patients. Aim of the study was ultrasound evaluation of intima media thickness on carotid arteries (as a marker of atherosclerosis, in dialysis patients and its correlation with proposed risk factors. Intima media thickness was measured in 45 dialysis patients with no signs of cardiovascular diseases (15 on peritoneal dialysis, group I,30 on hemodialysis, group II and 20 healthy controls. The mean carotid artery intima media thickness was significantly higher in dialysis patients than in control group. According to intima media thickness, dialysis patients were divided in group A (patient with intima media thickness less or equal 0,720 mm and group B (intima media thickness higher then 0,720mm. Intima media thickness in bout group was correlated with proposed risk factors. In group A there was not significant correlation of intima media thickness with risk factors. In group B significant correlation have been found between intima media thickness and LDL, VLDL cholesterol, body mass index and systolic, diastolic and mean blood pressure. Although atherosclerosis was not the only cause for cardiovascular morbidity and mortality, it has a dominant role in dialysis patients. Augmented intima media thickness could be early marker of atherosclerosis. The risk factors of great influence on intima media thickness are lipid disturbances, obesity and hypertension.

  2. Carotid Artery Segmentation in Ultrasound Images and Measurement of Intima-Media Thickness

    OpenAIRE

    Vaishali Naik; R.S. Gamad; P.P. Bansod

    2013-01-01

    Background. The segmentation of the common carotid artery (CCA) wall is imperative for the determination of the intima-media thickness (IMT) on B-mode ultrasound (US) images. The IMT is considered an important indicator in the evaluation of the risk for the development of atherosclerosis. In this paper, authors have discussed the relevance of measurements in clinical practices and the challenges that one has to face while approaching the segmentation of carotid artery on ultrasound images. Th...

  3. Age dependent dynamics of intima-media complex thickness in elderly patients with arterial hypertension

    Directory of Open Access Journals (Sweden)

    Sadjaya L.A.

    2011-09-01

    Full Text Available Aim: To estimate the dynamics of intima-media complex in elderly patients with arterial hypertension. Materials: 179 elderly patients with arterial hypertension were involved in the study. Mean intima-media wall thickness (IMT of common carotid arteries in plaque-free sites and prevalence of plaques were evaluated by B-mode ultrasound investigation (Philips Envisor HD, USA. Results: IMT changing was of nonlinear character, remained stable up to 74 years. Mean rate of the following IMT augmentation was 0.157 mm per year. Frequency of atherosclerotic plaque revealing was significantly increased since the 7th decade. Significant correlation between IMT and systolic, diastolic, mean blood pressure levels or medication spectrum was not revealed. Conclusion: Received data proved significant influence of aging upon IMT enlargement

  4. Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness

    OpenAIRE

    Nienhuis, Hans LA; de Leeuw, Karina; Bijzet, Johan; van Doormaal, Jasper J.; van Roon, Arie M.; Smit, Andries J; Graaff, Reindert; Kallenberg, Cees GM; Bijl, Marc

    2010-01-01

    Introduction The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation. Methods Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was asse...

  5. The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

    OpenAIRE

    Park, Jin-Kee; Park, Hyuntae; Kim, Kwi-Baek

    2015-01-01

    [Purpose] The aim of this study was to examine the relationships between the amount and distribution of body fat and the carotid intima-media thickness to explore whether coronary artery disease risk may be mediated through effects on the amount of fat mass in older adults. [Subjects and Methods] A total of 200 elderly females was participated. The percentage of body fat mass was measured by the bioelectrical impedance analysis method, and the carotid intima-media thickness was measured by B-...

  6. Intima-Media Thickness Does Not Differ between Two Common Carotid Artery Segments in Children

    OpenAIRE

    Heidi Weberruß; Raphael Pirzer; Robert Dalla Pozza; Heinrich Netz; Renate Oberhoffer

    2016-01-01

    Carotid intima-media thickness (cIMT) is a surrogate marker of early atherosclerotic changes in children. cIMT-studies are hard to compare, due to variations in ultrasound protocols, especially regarding the common carotid artery (CCA) segment measured in relation to the bulb. This study's purpose was therefore to compare two distinct CCA segments in children, to see if cIMT values differ substantially according to the site of measurement. cIMT was assessed after power calculation in 30 child...

  7. Association of carotid artery intima-media thickness and cardiovascular risk factors in adult

    International Nuclear Information System (INIS)

    Increased intima-media thickness (IMT) of the common carotid artery is an early marker of atherosclerosis and a powerful predictor of coronary and cerebrovascular diseases. The purpose of this study was to evaluate the correlation between carotid artery IMT and cardiovascular risk factors. Total 134 adult were performed with Ultrasonography to measure IMT at common carotid artery, the physical measurements and blood tests, the following results were obtained. As a result, IMT showed higher value in male IMT than female IMT. And, the IMT increased according to the age increased. Also, TC and AI have positive significant correlation with IMT. In Conclusion, cardiovascular risk factors with adult are associated with increased IMT of common carotid artery

  8. Association of carotid artery intima-media thickness and cardiovascular risk factors in adult

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Young [Dept. of Diagnostic Radiology, Dankook University Hospital, Cheonan (Korea, Republic of); Kim, Hwa Sun [Dept. of Radiological Technology, Ansan University, Ansan (Korea, Republic of); Kim, Shin Young [Dept. of Anatomy and Cell Biology, School of Medicine, Hanyang University, Seoul (Korea, Republic of)

    2013-03-15

    Increased intima-media thickness (IMT) of the common carotid artery is an early marker of atherosclerosis and a powerful predictor of coronary and cerebrovascular diseases. The purpose of this study was to evaluate the correlation between carotid artery IMT and cardiovascular risk factors. Total 134 adult were performed with Ultrasonography to measure IMT at common carotid artery, the physical measurements and blood tests, the following results were obtained. As a result, IMT showed higher value in male IMT than female IMT. And, the IMT increased according to the age increased. Also, TC and AI have positive significant correlation with IMT. In Conclusion, cardiovascular risk factors with adult are associated with increased IMT of common carotid artery.

  9. Carotid Artery Segmentation in Ultrasound Images and Measurement of Intima-Media Thickness

    Directory of Open Access Journals (Sweden)

    Vaishali Naik

    2013-01-01

    Full Text Available Background. The segmentation of the common carotid artery (CCA wall is imperative for the determination of the intima-media thickness (IMT on B-mode ultrasound (US images. The IMT is considered an important indicator in the evaluation of the risk for the development of atherosclerosis. In this paper, authors have discussed the relevance of measurements in clinical practices and the challenges that one has to face while approaching the segmentation of carotid artery on ultrasound images. The paper presents an overall review of commonly used methods for the CCA segmentation and IMT measurement along with the different performance metrics that have been proposed and used for performance validation. Summary and future directions are given in the conclusion.

  10. Cigarette smoking in military pilots and intima-media thickness of the carotid arteries

    Directory of Open Access Journals (Sweden)

    Jovelić Stojan

    2005-01-01

    Full Text Available Background. It is well known that smoking is associated with an increase in arterial wall thickness. However, most studies of this problem have been undertaken in age and sex heterogeneous groups, as well as in patients with already present other conventional risk factors. The aim of this study was to assess the effect of cigarette smoking on arterial wall thickness of the common carotid artery in asymptomatic pilots. Methods. The imaging of intima−media thickness of the posterior wall of the distal 1 cm of both common carotid arteries was performed using a B mode ultrasound device, in 39 pilots (37.05 ± 6.66 years, for whom smoking was the single cardiovascular risk factor. Comparisons were made with 49 non-smokers (35.12 ± 7.39 years. Results. The posterior walls of both common carotid arteries were thicker in smokers (left, p < 0.05; right, p > 0,05. Intima-media thickness was significantly lower on the right side than on the left side in both smokers and nonsmokers (p < 0.01. Conclusion. Cigarette smoking as the single cardiovascular risk factor was associated with the wall thickness of the carotid arteries in our study. This finding indicated that early atherosclerosis was already present in pilots - smokers entering middle age.

  11. Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children

    Institute of Scientific and Technical Information of China (English)

    YANG Xiao-zheng; LIU Ying; MI Jie; TANG Chao-shu; DU Jun-bao

    2007-01-01

    Background Atherosclerosis as a cardiovascular disease was found to begin even in the fetal period. However,information about risk factors of pre-clinical atherosclerosis in childhood has been limited. Hence, this study was aimed to find out the risk factors of atherosclerosis by measuring the carotid artery intima-media thickness in children. High resolution B-mode ultrasound used to examine the carotid artery intima-media thickness was demonstrated to be useful in finding the early carotid structural changes.Methods The study included 79 children who were divided into two groups according to their ages: group Ⅰ consisted of 42 children with ages from 5 to 9 years and group Ⅱ consisted of 37 children with ages from 10 to 18 years, Among them,23 had a positive family history for risk, such as hypertension, obesity or dyslipidemia. Blood samples were collected and total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein were assayed. The carotid artery intima-media thickness was measured by ultrasound. Comparisons were done between the two groups using Student's t tests and Chi-square analysis. Body mass index, blood pressure, levels of lipids, family history and the carotid artery intima-media thickness were calculated by conditional logistic regression analysis.Results Compared with the children without a positive family history, the incidence of the increased carotid artery intima-media thickness was significantly high (x2=4.364, P<0.05). There were no statistically significant differences between left and right carotid arteries in carotid artery intima-media thickness (P>0.05). In this study, diastolic blood pressure and the atherosclerosis index were suggested to be the risk factors to the thickened carotid artery intima-media thickness. In group I the diastolic blood pressure's odds radio was 1.187 (P=0.035) and the atherosclerosis index odds radio was 37.165 (P=0.001); in group Ⅱ the diastolic blood pressure's odds

  12. Intima-media Thickness and Arterial Stiffness of Carotid Artery in Korean Patients with Behçet's Disease

    OpenAIRE

    Rhee, Moo-Yong; Chang, Hyun Kyu; Kim, Seong-Kyu

    2007-01-01

    Behçet's disease (BD) is a systemic vasculitis involving diverse sizes of arteries and veins. We performed this study to evaluate the vascular changes by assessment of the arterial stiffness and intima-media thickness (IMT) of carotid artery in Korean patients with BD. Forty-one patients with BD and age-, and sex-matched 53 healthy subjects were recruited in this study. Carotid arterial stiffness and IMT were assessed by using high-resolution B-mode ultrasonography. Arterial stiffness paramet...

  13. The Impact of Intima-media Thickness of Radial Artery on Early Failure of Radiocephalic Arteriovenous Fistula in Hemodialysis Patients

    OpenAIRE

    KIM, YOUNG OK; Choi, Yeong Jin; Kim, Ji Il; Kim, Young Soo; Kim, Byung Soo; Park, Chul Whee; Song, Ho Cheol; Yoon, Sun Ae; Chang, Yoon Sik; Bang, Byung Kee

    2006-01-01

    This study was performed to investigate the impact of intima-media thickness (IMT) of radial artery on early failure of radiocephalic arteriovenous fistula (AVF) in hemodialysis (HD) patients. Ninety uremic patients undergoing radiocephalic AVF operation were included in this study. During the operation, 10-mm long partial arterial walls were removed with elliptical form for microscopic analysis. Specimens were stained with trichrome and examined by a pathologist blinded to the clinical data....

  14. Carotid, aorta and renal arteries intima-media thickness in patients with sporadic idiopathic hypoparathyroidism

    Directory of Open Access Journals (Sweden)

    Deshraj Meena

    2015-01-01

    Full Text Available Background: Alteration in homeostasis of calcium, phosphate and parathyroid hormone (PTH predispose to vascular calcification that increases the risk of cardiovascular morbidity and mortality. The data on this aspect are scarce in patients with sporadic idiopathic hypoparathyroidism (SIH. Objective: The aim was to assess the effect of altered calcium, phosphate and PTH homeostasis in patients with SIH on intima media thickness (IMT, a surrogate marker of increased vascular risk. Methods: In this case-control study, we measured carotid IMT (CIMT, aortic IMT (AIMT and renal arteries IMT (RIMT in 30 consecutive patients with SIH, and compared with healthy subjects. IMT was measured by ultrasound by a single operator blinded to subject′s details. Results: CIMT, AIMT, RIMT values in patients with SIH were significantly more than healthy subjects (0.60 ± 0.08 mm vs. 0.52 ± 0.09 mm, P = 0.001; 0.73 ± 0.09 mm vs. 0.65 ± 0.10, P = 0.004; and 0.34 ± 0.04 mm vs. 0.30 ± 0.05, P = 0.003, respectively. Clinical or biochemical parameters did not correlate with CIMT, AIMT and RIMT in patients with SIH. Conclusion: The vascular risk is increased in patients with SIH as assessed by CIMT, AIMT, and RIMT.

  15. Determination of site-specific carotid-intima media thickness: common –carotid artery and carotid bifurcation in hypercholesterolemia patients

    OpenAIRE

    Perwaiz Khan, Samia; Gul, Pashmina; Khemani, Saleem; Yaqub, Zia

    2013-01-01

    Objective: To determine site specific carotid intima-media thickness: common–carotid artery and carotid bifurcation in hypercholesterolemia patients as a marker for atherosclerosis. Methods: Fifty patients with hypercholesterolemia and twenty controls were selected after getting informed consent regarding the investigation of carotid- intima media thickness by B-mode ultrasound. All the patients of hypercholesterolemia with LDL-C > 160mg/dL had family history of coronary artery diseases. This...

  16. Factors associated with gender difference in the intima-media thickness of the common carotid artery

    Energy Technology Data Exchange (ETDEWEB)

    Tan, T.-Y.; Lu, C.-H.; Lin, T.-K.; Liou, C.-W. [Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Chuang, Y.-C., E-mail: tengyeowtan@yahoo.co [Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Schminke, U. [Department of Neurology, Ernst Moritz Arndt University, Greifswald (Germany)

    2009-11-15

    Aim: To investigate the gender differences associated with a thinner intima-media thickness (IMT) of the common carotid artery (CCA) in women. Materials and methods: In a sample of 218 consecutive healthy volunteers comprising 110 men and 108 women, the IMT of the CCA was measured using B-mode ultrasonography. Blood pressure, fasting blood sugar, body mass index (BMI), blood lipid profile, homocysteine, folic acid, uric acid, high sensitive C-reactive protein, and thiobarbituric acid reactive substances (TBARS) levels were measured and compared with each other in both genders. Results: The IMT of the CCA was significantly thinner in women than in men (p = 0.012). Blood pressure, fasting plasma glucose, BMI, low-density lipoprotein cholesterol, triglycerides, homocysteine, uric acid, and TBARS were significantly (p < 0.05) lower, folic acid and high-density lipoprotein cholesterol (HDL-C) were significantly (p < 0.0001) higher in women compared with men. Multivariable logistic regression analysis revealed that higher serum levels of homocysteine, uric acid, and TBARS, and lower serum levels of HDL-C were significantly (p < 0.05) associated with male sex. Multiple linear regression analysis further revealed that age, sex, and BMI were independently associated with CCA IMT. Conclusions: The IMT of the CCA was thinner in women than in men. Traditional vascular risk factors explain only a small amount of variance in multivariate regression models supporting the hypothesis that other behavioural, sex hormone-related or genetic factors, which have not been sufficiently explored so far, may play a role in the gender differences of IMT.

  17. Factors associated with gender difference in the intima-media thickness of the common carotid artery

    International Nuclear Information System (INIS)

    Aim: To investigate the gender differences associated with a thinner intima-media thickness (IMT) of the common carotid artery (CCA) in women. Materials and methods: In a sample of 218 consecutive healthy volunteers comprising 110 men and 108 women, the IMT of the CCA was measured using B-mode ultrasonography. Blood pressure, fasting blood sugar, body mass index (BMI), blood lipid profile, homocysteine, folic acid, uric acid, high sensitive C-reactive protein, and thiobarbituric acid reactive substances (TBARS) levels were measured and compared with each other in both genders. Results: The IMT of the CCA was significantly thinner in women than in men (p = 0.012). Blood pressure, fasting plasma glucose, BMI, low-density lipoprotein cholesterol, triglycerides, homocysteine, uric acid, and TBARS were significantly (p < 0.05) lower, folic acid and high-density lipoprotein cholesterol (HDL-C) were significantly (p < 0.0001) higher in women compared with men. Multivariable logistic regression analysis revealed that higher serum levels of homocysteine, uric acid, and TBARS, and lower serum levels of HDL-C were significantly (p < 0.05) associated with male sex. Multiple linear regression analysis further revealed that age, sex, and BMI were independently associated with CCA IMT. Conclusions: The IMT of the CCA was thinner in women than in men. Traditional vascular risk factors explain only a small amount of variance in multivariate regression models supporting the hypothesis that other behavioural, sex hormone-related or genetic factors, which have not been sufficiently explored so far, may play a role in the gender differences of IMT.

  18. Intima-media thickness and arterial stiffness of carotid artery in Korean patients with Behçet's disease.

    Science.gov (United States)

    Rhee, Moo-Yong; Chang, Hyun Kyu; Kim, Seong-Kyu

    2007-06-01

    Behçet's disease (BD) is a systemic vasculitis involving diverse sizes of arteries and veins. We performed this study to evaluate the vascular changes by assessment of the arterial stiffness and intima-media thickness (IMT) of carotid artery in Korean patients with BD. Forty-one patients with BD and age-, and sex-matched 53 healthy subjects were recruited in this study. Carotid arterial stiffness and IMT were assessed by using high-resolution B-mode ultrasonography. Arterial stiffness parameters such as carotid arterial distensibility coefficient, stiffness index, and incremental elastic modulus (E(inc)) were significantly increased in BD patients compared with those in healthy subjects, but not in IMT. Positive relationship was noted between age and IMT, whereas age of onset was significantly associated with arterial stiffness in BD. This finding suggests impaired endothelial function before visible structural changes of arterial wall in BD. Age and age of onset may be an independent risk factor for carotid IMT and arterial stiffness, respectively. Further studies in more large populations are required to confirm our results. PMID:17596642

  19. The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness.

    Science.gov (United States)

    Dalan, Rinkoo; Liew, Huiling; Goh, Liuh Ling; Gao, Xiao; Chew, Daniel Ek; Boehm, Bernhard O; Leow, Melvin Khee Shing

    2016-09-01

    The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus. We examined the associations of the haptoglobin 2-2 genotype with C-reactive protein (high-sensitivity C-reactive protein) and carotid artery intima-media thickness, adjusting for age, gender, ethnicity, type 2 diabetes mellitus, smoking status, body mass index, blood pressure, glycated haemoglobin, non-high-density lipoprotein cholesterol and medications via logistic multivariate regression in 200 subjects (160 type 2 diabetes mellitus versus 40 healthy individuals). The prevalence of the haptoglobin 2-2 genotype was 58% (115/200), higher in the Indians than in Chinese (72% versus 45%, p = 0.001). Multivariate analysis showed that the haptoglobin 2-2 genotype was associated with high-sensitivity C-reactive protein [mean: 3.5 ± 3.9 versus 2.2 ± 2.6 mg/L (non-haptoglobin 2-2), p < 0.001], haptoglobin concentration [mean: 116.9 ± 54.4.0 versus 147.2 ± 54.5 mg/dL (non-haptoglobin 2-2), p < 0.001] and average carotid artery intima-media thickness (multiplied by 10) [6.15 ± 1.22 versus 5.98 ± 1.20 mm (non-haptoglobin 2-2), p = 0.013]. This pilot study shows an association of the haptoglobin 2-2 genotype with low-grade inflammation, haptoglobin concentration and carotid artery intima-media thickness in multi-ethnic Singapore. PMID:27190085

  20. Comparison between Carotid Intima-Media Thickness and Coronary Artery Calcification in the Prediction of Atherosclerosis in Diabetic Patients

    Directory of Open Access Journals (Sweden)

    Rusli Muljadi

    2014-04-01

    Full Text Available BACKGROUND: Cardiovascular disease is one of the atherosclerosis etiologies that can lead to death. Diabetes mellitus increases the risk of atherosclerosis. Screening tool is very beneficial for detecting atherosclerotic plaque, especially in subclinical atherosclerotic cases. Carotid intima-media thickness (CIMT and coronary artery calcification score (CACS are two kinds of tools that are widely used, and each of these tools has its own superiority. This study was aimed to investigate the sensitivity and specificity of both of these tools as screening tools. METHODS: The study was conducted with a cross sectional design involving 43 diabetic and 68 non-diabetic male subjects aged above 45 years old. All subjects fulfilled inclusion criteria. Carotid artery ultrasonography and CACS measurement were performed. RESULTS: Fischer exact test was used to show a significant correlation between CIMT and CACS (p<0.05. Diagnostic test was used to assess the sensitivity of CIMT toward CACS in above 75 percentile. The left common carotid artery (LCCA showed the highest sensitivity either in diabetic (76.4% or non-diabetic male subjects (90%. CONCLUSIONS: CIMT has the same sensitivity with CACS. CIMT can be used as the preferred screening tool for high risk patients and as a substitution tool to CACS for low risk patients in subclinical atherosclerosis detection. KEYWORDS: atherosclerosis, diabetes mellitus, carotid intima-media thickness, coronary artery calciication score.

  1. Comparison between Carotid Artery Wall Thickness Measured by Multidetector Row Computed Tomography Angiography and Intimae-Media Thickness Measured by Sonography

    OpenAIRE

    Živorad N. Savić; Ivan I. Soldatović; Milan D. Brajović; Aleksandra M. Pavlović; Dušan R. Mladenović; Vesna D. Škodrić-Trifunović

    2011-01-01

    The increased thickness of the carotid wall >1 mm is a significant predictor of coronary and cerebrovascular diseases. The purpose of our study was to assess the agreement between multidetector row computed tomography angiography (MDCTA) in measuring carotid artery wall thickness (CAWT) and color Doppler ultrasound (CD-US) in measuring intimae-media thickness (IMT). Eighty-nine patients (aged 35–81) were prospectively analyzed using a 64-detector MDCTA and a CD-US scanner. Continuous data wer...

  2. Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.

    Science.gov (United States)

    Meaney, Eduardo; Vela, Agustín; Samaniego, Virginia; Meaney, Alejandra; Asbún, Juan; Zempoalteca, Juan-Carlos; Elisa, Zárate N; Emma, Mendoza N; Guzman, Martin; Hicks, Juan; Ceballos, Guillermo

    2008-08-01

    1. Metabolic syndrome (MS) is one of the greatest public health problems in Mexico, where more than 75% of adults in urban populations are overweight or obese. Metabolic syndrome has several comorbidities, which result in a high cardiometabolic risk. 2. Some of the vasopathogenic phenomena in MS are caused by nitroxidant stress, secondary to cardiometabolic dysfunction. 3. The action of metformin to diminish or control MS remains a matter of debate. 4. In the present study, 60 patients with at least three diagnostic criteria for MS were divided into two groups. Both groups received similar dietary counselling, but one group was given 850 mg metformin daily. 5. The variables assessed were body mass index, waist circumference, systolic and diastolic blood pressures (SBP and DBP, respectively), total cholesterol (TC), high- and low-density lipoprotein-cholesterol, triglycerides (TG), fasting glucose, nitroxidant metabolites (free carbonyls, malondialdehyde, dityrosines and advanced oxidative protein products (AOPP)), nitric oxide (NO), carotid vascular stiffness, carotid intima-media thickness (IMT) and C-reactive protein (CRP). 6. After 1 year follow up, both groups reported weight loss, as well as decreases in waist circumference, SBP and DBP. 7. Patients on metformin exhibited reductions in TC and IMT and there were marked changes in nitroxidation: levels of carbonyls, dityrosines and AOPP were reduced, whereas those of NO were increased, indicating better endothelial function. In addition, in patients given metformin, CRP levels decreased. 8. In conclusion, metformin has a considerable beneficial effect on nitroxidation, endothelial function and IMT in patients with MS.

  3. Cigarette smoking in military pilots and intima-media thickness of the carotid arteries

    OpenAIRE

    Jovelić Stojan; Hajduković Zoran; Jovelić Aleksandra; Rađen Slavica

    2005-01-01

    Background. It is well known that smoking is associated with an increase in arterial wall thickness. However, most studies of this problem have been undertaken in age and sex heterogeneous groups, as well as in patients with already present other conventional risk factors. The aim of this study was to assess the effect of cigarette smoking on arterial wall thickness of the common carotid artery in asymptomatic pilots. Methods. The imaging of intima−media thickness of the posterior wall of the...

  4. Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients

    Directory of Open Access Journals (Sweden)

    Tana Mariangela

    2011-04-01

    Full Text Available Abstract Background Human immunodeficiency virus (HIV infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of extent, severity and progression of atherosclerosis. A cross-sectional cohort study was performed to compare the validity of two non-invasive arterial measures: carotid intima-media thickness (IMT, a parameter of atherosclerosis, and ophthalmic artery resistance index (OARI, an index of occlusive carotid artery disease. Methods A total of 95 patients receiving highly active antiretroviral therapy (HAART for more than 12 months were consecutively enrolled. IMT and OARI were measured by 7.5 MHz linear probe. Results There was a significant linear increase in IMT and OARI values as the grade of cardiovascular risk (0.70 and 0.69 for very low risk, 0.86 and 0.72 for low risk and 0.98 and 0.74 for medium/high risk, p 0.83 and an OARI > 0.72 were the most discriminatory values for predicting a cardiovascular risk ≥ 10% (sensibility 89.6% and 75.8%; sensitivity 70.5% and 68.4%; p Conclusions Our data indicate that OARI may have a potential as a new precocious marker of subclinical atherosclerosis in HIV-1-infected patients.

  5. Correlation between coronary artery disease severity, left ventricular mass index and carotid intima media thickness, assessed by radio-frequency

    Directory of Open Access Journals (Sweden)

    Ciccone Marco M

    2011-11-01

    Full Text Available Abstract Background Intima-media thickness of the common carotid artery (CCA-IMT is a validated marker of systemic atherosclerosis process. The aim of this study was to evaluate the association between coronary artery disease (CAD, left ventricular hypertrophy (LVH and CCA-IMT, assessed by Radio Frequency-Quality Intima Media Thickness (RFQIMT method, the next generation of IMT real-time measurement, based on the direct analysis of the radiofrequency signal and endowed with high accuracy and reproducibility in early detection of arterial wall thickness. Methods 115 patients (76 men, mean age: 65.1 ± 12 years referred to our department and shown significant (≥ 70% luminal obstruction stenosis at least in one major epicardial coronary artery were studied. Coronary angiograms were divided for severity and extent of the disease: 79 patients (69% had one, 24 patients (21% two, 12 patients (10% three major epicardial coronary arteries with ≥ 70% stenosis. All patients underwent echocardiography and carotid ultrasound examination, assessed by RF. Results Dividing RFQIMT data in tertiles, dyslipidaemia (31 patients with IMT ≥ 1.20 mm vs 16 with IMT = 0.91-1.19 vs 25 with IMT ≤ 0.9, p = 0.004, LVMI (153.5 ± 20.6 g/m2 in IMT ≥ 1.20 mm vs 131.2 ± 8.4 g/m2 in IMT = 0.91-1.19 mm vs 114.3 ± 11.1 g/m2 in IMT ≤ 0.9 mm, P 2 = 0.88, RFQIMT remained significantly associated with the dyslipidemia (regression coefficient ± standard error [SE]: 0.057 ± 0.023; p = 0.017, LVMI (regression coefficient ± SE: 0.01 ± 0.001; P Conclusions RFQIMT is a sophisticated method for carotid ultrasound evaluation. Its evaluation in patients with at least one important major epicardial coronary vessel stenosis would help the accuracy in the general assessment of the number of coronary lesions in these patients.

  6. Bilateral common carotid artery ultrasound for prediction of incident strokes using intima-media thickness and external diameter: an observational study

    OpenAIRE

    Eigenbrodt, Marsha L.; Evans, Gregory W.; Rose, Kathryn M; Bursac, Zoran; Tracy, Richard E.; Mehta, Jawahar L.; Couper, David J

    2013-01-01

    Background External common carotid artery (CCA) diameter and intima-media thickness (IMT) are independently associated with incident stroke and other cardiovascular events. Arterial geometry such as large IMT and large diameter may reflect vulnerable plaques and so impact stroke risk. Finally, arterial changes that exist bilaterally may increase stroke risk. Method We studied middle-aged men and women (n=7276) from a prospective observational study who had right (R) and left (L) CCA IMT and e...

  7. Endothelial dysfunction and brachial intima-media thickness: long term cardiovascular risk with claudication related to peripheral arterial disease: a prospective analysis.

    Directory of Open Access Journals (Sweden)

    Franz Hafner

    Full Text Available OBJECTIVE: Endothelial dysfunction plays a key role in the development, progression, and clinical manifestation of atherosclerosis, and in symptomatic peripheral arterial disease, endothelial dysfunction and enlarged intima-media thickness might be associated with increased cardiovascular risk. Flow-mediated dilatation and serologic parameters are used to evaluate individual endothelial function. Brachial intima-media thickness, a less recognized parameter of cardiovascular risk, is independently associated with coronary artery disease. The aim of this study was to evaluate the prognostic value of ultrasound and serologic parameters of endothelial function in relation to cardiovascular mortality in peripheral arterial disease. DESIGN: monocentric, prospective cohort study. METHODS: Flow mediated dilatation and brachial intima-media thickness were assessed in 184 (124 male patients with peripheral arterial disease (Rutherford stages 2-3. Serologic parameters of endothelial function included asymmetric dimethylarginine (ADMA, symmetric dimethylarginine (SDMA, and L-homoarginine. Cardiovascular events were recorded during a follow-up of 99.1±11.1 months. Subjects who died of noncardiovascular causes were excluded from further analysis. RESULTS: Eighty-two patients (44.6% died during follow-up after a mean duration of 49.7±28.3 months. There were 49 cardiovascular deaths (59.8% and 33 other deaths (40.2%. Flow mediated dilatation was associated with cardiovascular death [1.17% (0.0, 4.3 vs. 4.1% (1.2, 6.4, p<0.001]. Intima-media thickness was greater in patients who succumbed to cardiovascular disease [0.37 mm (0.30, 0.41] than in survivors [0.21 mm (0.15, 0.38, p<0.001]. Brachial intima-media thickness above 0.345 mm was most predictive of cardiovascular death, with sensitivity and specificity values of 0.714 and 0.657, respectively (p<0.001. Furthermore, ADMA levels above 0.745 µmol/l and SDMA levels above 0.825 µmol/l were significantly

  8. Evaluation of Carotid Arterial Intima-Media Thickness (IMT and Its Relation to Clinical Parameters in Japanese Children

    Directory of Open Access Journals (Sweden)

    Tamura,Hiroko

    2011-02-01

    Full Text Available The aim of this study was to evaluate the carotid arterial intima-media thickness (IMT and its relation to clinical parameters in Japanese children. Fifty-two healthy children (39 boys and 13 girls, aged 6-14 years, were enrolled in this cross-sectional investigation study. IMT of the common carotid artery was determined using ultrasonography. We also investigated anthropometric parameters, blood pressure (BP, lifestyles and blood examinations. The mean value of IMT was 0.4±0.1mm, which was lower than the normal value (1.0mm in adults. IMT was positively correlated with age (r=0.340 and height (r=0.346 in boys, while it was positively correlated with body mass index (BMI (r=0.584 and diastolic BP (DBP (r=0.563 in girls. In addition, IMT was associated with sleeping hours and hours of watching television (TV by using stepwise regression analysis. In conclusion, IMT increased with aging, and it was linked to some clinical parameters of atherosclerosis and lifestyles in children. Therefore, this reference data will be helpful for future assessment of age-related change in Japanese children in clinical practice, and IMT might be a good predictor of atherosclerosis in Japanese children.

  9. The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness.

    Science.gov (United States)

    Nieminen, Tuomo; Kähönen, Mika; Lehtimäki, Terho

    2006-03-01

    Different apolipoprotein combinations explain most of the functional differences between plasma lipoproteins. This emphasizes the pivotal role of apolipoproteins in the homeostasis and physiological control of lipid metabolism. Genetic polymorphisms of apolipoprotein (apo)A-I/C-III/A-IV, apoE and apoB have been suggested to modulate plasma lipid levels as well as the risk of coronary artery disease and stroke. Carotid artery intima-media thickness has been shown to represent preclinical atherosclerosis and has, therefore, been used as a surrogate in quantifying the early stages of atherosclerosis. The effects of the polymorphisms in apoA-I/C-III/A-IV and apoB on carotid intima-media thickness are poorly known. The corresponding influence of apoE polymorphisms has been studied more extensively, but the results are not yet conclusive. In this review, these results are presented in detail and the potential reasons and mechanisms for the discrepancies are discussed. PMID:19804074

  10. Association of the Cardioankle Vascular Index and Ankle-Brachial Index with Carotid Artery Intima Media Thickness in Hemodialysis Patients

    Directory of Open Access Journals (Sweden)

    Tomohito Gohda

    2013-01-01

    Full Text Available The objectives of the present study are (1 to compare the cardioankle vascular index (CAVI, ankle-brachial index (ABI, and carotid artery intima-media thickness (CA-IMT between HD patients with and without type 2 diabetes (T2D or prevalence of cardiovascular (CV disease and (2 also to evaluate the relationship of these indices with CA-IMT in these patients according to ABI levels. This study consisted of 132 HD patients with T2D and the same number of patients without T2D. The patients with diabetes or prevalence of CV disease had significantly higher CA-IMT and lower ABI values than those without diabetes or prevalence of CV disease, respectively. Although diabetic patients had higher CAVI than those without diabetes, CAVI did not differ between patients with or without prevalence of CV disease. In univariate analysis, CA-IMT was more strongly correlated with ABI than CAVI. However, the opposite was true in patients with an ABI value of more than 0.95. Both indices were significantly correlated with CA-IMT although ABI was a powerful determinant than CAVI. It appears that both indices are associated with CA-IMT in HD patients, especially with an ABI value of more than 0.95.

  11. The Effects of Rituximab on Lipids, Arterial Stiffness and Carotid Intima-Media Thickness in Rheumatoid Arthritis

    Science.gov (United States)

    2016-01-01

    The aim of the study was to examine lipid profiles, arterial stiffness (AS), carotid intima-media thickness (cIMT), in 55 women with RA without overt cardiovascular disease (СVD) treated with rituximab (RTX).The following parameters were recorded before and 24 weeks after RTX therapy (2 infusions of 500 or 1,000 mg RTX intravenously, fortnightly): plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, DAS 28-ESR, serum C-reactive protein (CRP), RF IgM, AS (SI - stiffness index, RI – reflection index) by digital volume pulse contour analysis (Micro Medical, UK), and common cIMT by high-resolution B-mode carotid ultrasound. Based on the European League Against Rheumatism (EULAR) criteria, patients were divided into two groups: 1) moderate/good response to RTX therapy after 24 weeks (41 patients, 75%), 2) no response to RTX therapy (14 patients, 25%). Effective RTX therapy resulted in 9% increase in TC, 23% increase in HDL-C and 14% decrease in atherogenic index, 57% decrease in SI and 24% decrease in RI. We observed a 9% decrease of cIMTmax at 24 weeks. The improvement of cardiovascular parameters was accompanied by statistically significant decreases of CRP, ESR, RF IgM and DAS 28 in group 1 (P therapy exerted favorable effects on lipid profile, AS and cIMT in women with RA without overt CVD. PMID:26839473

  12. Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

    OpenAIRE

    Mohamed A. Amin; Alsiagy A. Salama; Ashraf M. Elaggan; Salwa E. Elsayed

    2015-01-01

    Objectives: Firstly to assess the prevalence of subclinical atherosclerosis and endothelial dysfunction by high resolution ultrasound measurements of carotid intima media thickness (CIMT) and brachial artery flow mediated dilatation percentage (FMD%) in patients with rheumatoid arthritis (RA), secondly to analyze the correlation of CIMT and FMD% with different clinical and laboratory parameters, third aim was to analyze the relationship between CIMT and FMD%. Patients and methods: The pros...

  13. A Computer-Aided Diagnosis System for Measuring Carotid Artery Intima-Media Thickness (IMT) Using Quaternion Vectors.

    Science.gov (United States)

    Kutbay, Uğurhan; Hardalaç, Fırat; Akbulut, Mehmet; Akaslan, Ünsal; Serhatlıoğlu, Selami

    2016-06-01

    This study aims investigating adjustable distant fuzzy c-means segmentation on carotid Doppler images, as well as quaternion-based convolution filters and saliency mapping procedures. We developed imaging software that will simplify the measurement of carotid artery intima-media thickness (IMT) on saliency mapping images. Additionally, specialists evaluated the present images and compared them with saliency mapping images. In the present research, we conducted imaging studies of 25 carotid Doppler images obtained by the Department of Cardiology at Fırat University. After implementing fuzzy c-means segmentation and quaternion-based convolution on all Doppler images, we obtained a model that can be analyzed easily by the doctors using a bottom-up saliency model. These methods were applied to 25 carotid Doppler images and then interpreted by specialists. In the present study, we used color-filtering methods to obtain carotid color images. Saliency mapping was performed on the obtained images, and the carotid artery IMT was detected and interpreted on the obtained images from both methods and the raw images are shown in Results. Also these results were investigated by using Mean Square Error (MSE) for the raw IMT images and the method which gives the best performance is the Quaternion Based Saliency Mapping (QBSM). 0,0014 and 0,000191 mm(2) MSEs were obtained for artery lumen diameters and plaque diameters in carotid arteries respectively. We found that computer-based image processing methods used on carotid Doppler could aid doctors' in their decision-making process. We developed software that could ease the process of measuring carotid IMT for cardiologists and help them to evaluate their findings. PMID:27137786

  14. Atherosclerosis and rheumatoid arthritis: relationships between intima-media thickness of the common carotid arteries and disease activity and disabilty

    Directory of Open Access Journals (Sweden)

    G. La Montagna

    2011-09-01

    Full Text Available Objectives. To investigate the intima-media thickness of the common carotid arteries (IMT-CCA in patients with Rheumatoid Arthritis (RA, and its relationships with classical atherosclerosis risk factors and disease features i.e. duration, activity and disability. Methods. 48 RA patients (35 F, 13 M; age ed 26-69 years median 55; disease duration 1-18 years, median 8, and 22 controls (16 F, 6 M; age 28-66, median 50 matched for classical atherosclerosis risk factors, i.e. age, sex, smoking, blood pressure, body mass index, diabetes, familiarity, and for postemopausal status, were studied. IMT and plaques were measured in the left and right common carotid arteries. Serum total cholesterol, trygliceridies, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoliprotein AI, apolipoprotein B, and rheumatoid factor were determined in patients and controls. The DAS28, the HAQ-DI and disease duration were considered as clinical parameters reflecting disease status. Results. The IMT-CCA (mean ± SD was significantly greater in the 48 RA patients than in the 22 controls subjects (1.00±0.25 vs. 0.78±0.21; p=0.0007. In the 70 subjects investigated CCA-IMT resulted to be significantly correlated with diastolic blood pressure, body mass index, triglycerides and RA status. In the 48 RA patients no correlation was detected with either disease duration or activity or disability. Conclusion: our study confirms an increased IMT in RA patients without any clinically evident manifestation of cardiovascular disease. It supports the existence of subclinical atherosclerosis in RA.

  15. RELATIONSHIP OF CAROTID ARTERIES INTIMA-MEDIA THICKNESS WITH INFECTIOUS, IMMUNE, METABOLIC FACTORS AND INFLAMMATION MARKERS IN HEALTHY PERSONS

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2014-07-01

    Full Text Available Aim – to examine the relationship of arteries wall thickness with the indicators characterizing the infectious, immune, metabolic status inapparently healthy individuals.Materials and methods. The study included 342 patients (mean age 43.7 ± 0.5 years that in the process of cluster analysis on the thicknessof the intima-media thickness (IMT were divided into 3 groups. Group 1 consisted of patients with no risk factors of cardiovascular disease,2nd – patients with presence of these factors, 3rd – patients with atherosclerotic plaques in the carotid artery. All patients were examinedin complex: ultrasound of vessels measurement on the Aloka 5000 with IMT, evaluation of lipid profile, glucose level, determination of C-reactive protein (CRP in blood plasma and cytokines – tumor necrosis factor-α (TNF-α, interferon-γ (IFN-γ, interleukin (IL -1, -8, -4, specific antibody immunoglobulin G (IgG to cytomegalovirus (CMV, herpes simplex virus type 1 (HSV-1 , C. pneumoniae, H. pylori and β-hemolytic streptococci group A. Immune system status was assessed by innate and acquired immunity factors.Results. In groups of examined patients by increasing IMT of the common carotid artery infectious viruses (CMV, HSV-1 burden increased,what was obligatory for all groups. In the 3rd group, in 45 % of patients C. pneumoniae was found. In the 2nd and 3rd groups weakening ofacquired immunity was found out – reducing the total number of lymphocytes and T-lymphocytes, the increase of CRP and proinflammatory cytokines (IL-1, -8, IFN-γ, TNF-α, it was indicating development of inflammatory process, and in the third group it took characters of the system inflammatory response. In cluster analysis it was revealed that the process of thickening of the vascular wall is influenced by complex factors – infectious, metabolic and immune.Conclusion. The presence of the close relationship between the thickness of vessel walls and infectious, metabolic (lipid and

  16. RELATIONSHIP OF CAROTID ARTERIES INTIMA-MEDIA THICKNESS WITH INFECTIOUS, IMMUNE, METABOLIC FACTORS AND INFLAMMATION MARKERS IN HEALTHY PERSONS

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2011-01-01

    Full Text Available Aim – to examine the relationship of arteries wall thickness with the indicators characterizing the infectious, immune, metabolic status inapparently healthy individuals.Materials and methods. The study included 342 patients (mean age 43.7 ± 0.5 years that in the process of cluster analysis on the thicknessof the intima-media thickness (IMT were divided into 3 groups. Group 1 consisted of patients with no risk factors of cardiovascular disease,2nd – patients with presence of these factors, 3rd – patients with atherosclerotic plaques in the carotid artery. All patients were examinedin complex: ultrasound of vessels measurement on the Aloka 5000 with IMT, evaluation of lipid profile, glucose level, determination of C-reactive protein (CRP in blood plasma and cytokines – tumor necrosis factor-α (TNF-α, interferon-γ (IFN-γ, interleukin (IL -1, -8, -4, specific antibody immunoglobulin G (IgG to cytomegalovirus (CMV, herpes simplex virus type 1 (HSV-1 , C. pneumoniae, H. pylori and β-hemolytic streptococci group A. Immune system status was assessed by innate and acquired immunity factors.Results. In groups of examined patients by increasing IMT of the common carotid artery infectious viruses (CMV, HSV-1 burden increased,what was obligatory for all groups. In the 3rd group, in 45 % of patients C. pneumoniae was found. In the 2nd and 3rd groups weakening ofacquired immunity was found out – reducing the total number of lymphocytes and T-lymphocytes, the increase of CRP and proinflammatory cytokines (IL-1, -8, IFN-γ, TNF-α, it was indicating development of inflammatory process, and in the third group it took characters of the system inflammatory response. In cluster analysis it was revealed that the process of thickening of the vascular wall is influenced by complex factors – infectious, metabolic and immune.Conclusion. The presence of the close relationship between the thickness of vessel walls and infectious, metabolic (lipid and

  17. [Prediction of coronary artery stenosis by measurement of total plaque area and thickness versus intima media thickness of the carotid artery].

    Science.gov (United States)

    Adams, Ansgar; Bojara, Waldemar

    2015-08-01

    Total plaque area (TPA), maximum plaque thickness and intima media thickness (IMT) in the carotid arteries of 431 patients aged 27-88 years were measured 1 day before a planned coronary artery angiography without any clinical knowledge about the patient. Age-related cut-off values of the TPA for the presence of coronary stenosis were evaluated. Using ultrasound four types of carotid artery atherosclerosis were identified. The accuracy of detection of cardiovascular coronary stenosis was 87% for types III and IVb. No type I patient had coronary stenosis. The IMT was significantly less predictive: the area under the curve (AUC) for TPA by age and plaque thickness was 0.82 (95% CI: 0.78-0.85) versus IMT 0.59 (95% CI: 0.54-0.64, p = 0.001). Prediction with TPA measurement by age and plaque thickness was better than TPA alone: AUC 0.82 (95% CI: 0.78-0.85) versus 0.77 (95% CI: 0.73-0.81, p = 0.0028), respectively. In a second cohort of 2566 healthy men and 1216 healthy women aged between 20 and 64 years who were examined in an occupational screening program, 11.2% of the men and 3.4% of the women showed a type III or IVb result. In the mean follow-up of period of 23.4 ± 14.4 months, 14 heart attacks, 7 bypass operations and 3 stent implantations occurred and 6 subjects showed coronary stenosis between 50% and 95% in coronary angiography. In the baseline examination 26 out of 30 patients showed a type III or IVb result. In the case of men and women with types III and IVb diagnosis by ultrasound, pharmaceutical treatment could be indicated in order to reduce the risk of cardiovascular events. Type I patients do not need preventive medication or coronary catheterization.

  18. Comparison between Carotid Artery Wall Thickness Measured by Multidetector Row Computed Tomography Angiography and Intimae-Media Thickness Measured by Sonography

    Directory of Open Access Journals (Sweden)

    Živorad N. Savić

    2011-01-01

    Full Text Available The increased thickness of the carotid wall >1 mm is a significant predictor of coronary and cerebrovascular diseases. The purpose of our study was to assess the agreement between multidetector row computed tomography angiography (MDCTA in measuring carotid artery wall thickness (CAWT and color Doppler ultrasound (CD-US in measuring intimae-media thickness (IMT. Eighty-nine patients (aged 35–81 were prospectively analyzed using a 64-detector MDCTA and a CD-US scanner. Continuous data were described as the mean value ± standard deviation, and were compared using the Mann–Whitney U test. A p value <0.05 was considered significant. Bland–Altman statistics were employed to measure the agreement between MDCTA and CD-US. CAWT ranged from 0.62 to 1.60 mm, with a mean value of 1.09 mm. IMT ranged from 0.60 to 1.55 mm, with a mean value of 1.06 mm. We observed an excellent agreement between CD-US and MDCTA in the evaluation of the common carotid artery thickness, with a bias between methods of 0.029 mm (which is a highly statistically important difference of absolute values [t = 43.289; p < 0.01] obtained by paired T test, and limits of agreement from 0.04 to 0.104. Pearson correlation coefficient was 0.9997 (95% CI 0.9996–0.9998; p < 0.01. We conclude that there is an excellent correlation between CAWT and IMT measurements obtained with the MDCTA and CD-US.

  19. Comparison of tomographic coronary artery calcification index (calcium score) and ultrasonographic measurement of intima-media complex thickness in diabetic subjects

    International Nuclear Information System (INIS)

    At present, there is a number of diagnostic imaging procedures allowing for the evaluation of atherosclerosis. The earliest, subclinical stage of atherosclerosis can be visualized with the development of computed tomography (CT) and ultrasound (US) techniques. Therefore, the purpose of this study was to assess the degree of coronary artery calcification and carotid intima-media thickness in diabetic subjects divided into different age groups. Fifty-six men, aged from 18 to 72 were included in the study. Participants were divided into 4 groups according to age (18–30, 31–45, 46–60 and more than 60 years). Two tests were performed: coronary calcium score (CS) determination and intima-media thickness (IMT) in ultrasound. CS was performed using a multi-slice scanner. Images were analyzed using the Agatson method. Ultrasound examinations were performed using a 9–12-MHz linear transducer. The correlation coefficient between calcium score index (CSI) and age of patients was 0.52 (p<0.001). The correlation between duration of diabetes and CSI was significantly lower (r=0.3; p<0.05). The increase of IMT is associated with age to a much greater extent and the correlation coefficient was 0.63 (p<0.001). IMT depended on the duration of diabetes, but the correlation was also weak (r=0.35; p<0.01). Comparison of the findings obtained in the presented study and in the group of healthy subjects proves that influence of diabetes on vascular deterioration may be observed, even among young individuals. Obtained results allow to make the following conclusions: 1. Calcium score index remains low in the group of male patients with diabetes before the age of 45. 2. Intima-media thickness correlates well with age (r=0.6; p<0.05) and weaker with the duration of diabetes (r=0.35; p<0.05). 3. IMT assessment may be a useful tool to identify the increased predisposition to atherosclerosis, also before the age of 30

  20. Evaluation of intima-media thickness of carotid artery in obese children by using ultrasound radiofrequency data based quality intima-media thickness technology%超声射频信号血管内中膜分析技术评价肥胖儿童颈动脉内中膜厚度

    Institute of Scientific and Technical Information of China (English)

    金晔; 汤庆娅; 陶晔璇; 薛敏波; 沈理笑; 陈亚青

    2011-01-01

    目的:应用超声射频信号血管内中膜分析(quality intima-media thickness,QIMT)技术测量肥胖儿童的颈动脉内中膜厚度(intima-media thickness,IMT),探讨肥胖儿童代谢异常状况与颈动脉IMT间的关系.方法:由1名高年资超声医师应用QIMT技术,测量32例肥胖儿童(肥胖组)和20名正常对照儿童(对照组)的双侧颈总动脉IMT.结果:肥胖组与对照组儿童的空腹血糖(FBG)、总胆固醇(TCH)及低密度脂蛋白(LDL)差异均无统计学意义(P>0.05);肥胖组儿童的三酰甘油(TG)高于对照组,差异有统计学意义(P<0.01),高密度脂蛋白(HDL)则明显低于对照组,差异有统计学意义(P<0.05);肥胖组儿童的颈总动脉IMT明显高于对照组,差异亦有统计学意义(P<0.01).结论:肥胖儿童的颈动脉IMT已开始增加,并可合并高脂血症,提示动脉硬化(AS)是可在小儿时期得病、成人发病.超声检查颈动脉IMT简便、安全无创,可作为早期发现AS的一个良好的预报因子.%Objective To study whether atherosclerosis begins in childhood by measuring the intima-media thickneas of carotid artery in obese children using ultrasound radiofrequency data based quality intima-media thickness (QIMT) technology. Methods Intima-media thickness of carotid artery was measured in 32 obese children and 20 healthy children (control group) by QIMT. Blood lipid profiles and fasting blood glucose were measured. Results There were no differences in fasting blood glucose, total cholesterol and low density lipoprotein levels between the two groups (P>0.05),however, high density lipoprotein level was lower (P<0.05) and triglyceride level was higher in obese group (P<0.01). The intima-media thickness of carotid artery in obese group was significantly higher than that in control group (P<0.01).Conclusion The increasing of carotid artery intima-mcdia thickness starts in childhood and might be associated with hyperlipidemia, this suggests that

  1. Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

    NARCIS (Netherlands)

    Gertow, Karl; Sennblad, Bengt; Strawbridge, Rona J.; Oehrvik, John; Zabaneh, Delilah; Shah, Sonia; Veglia, Fabrizio; Fava, Cristiano; Kavousi, Maryam; McLachlan, Stela; Kivimaeki, Mika; Bolton, Jennifer L.; Folkersen, Lasse; Gigante, Bruna; Leander, Karin; Vikstrom, Max; Larsson, Malin; Silveira, Angela; Deanfield, John; Voight, Benjamin F.; Fontanillas, Pierre; Sabater-Lleal, Maria; Colombo, Gualtiero I.; Kumari, Meena; Langenberg, Claudia; Wareham, Nick J.; Uitterlinden, Andre G.; Gabrielsen, Anders; Hedin, Ulf; Franco-Cereceda, Anders; Nyyssonen, Kristiina; Rauramaa, Rainer; Tuomainen, Tomi-Pekka; Savonen, Kai; Smit, Andries J.; Giral, Philippe; Mannarino, Elmo; Robertson, Christine M.; Talmud, Philippa J.; Hedblad, Bo; Hofman, Albert; Erdmann, Jeanette; Reilly, Muredach P.; O'Donnell, Christopher J.; Farrall, Martin; Clarke, Robert; Franzosi, Maria Grazia; Seedorf, Udo; Syvanen, Ann-Christine; Hansson, Goran K.; Eriksson, Per; Samani, Nilesh J.; Watkins, Hugh; Price, Jacqueline F.; Hingorani, Aroon D.; Melander, Olle; Witteman, Jacqueline C. M.; Baldassarre, Damiano; Tremoli, Elena; de Faire, Ulf; Humphries, Steve E.; Hamsten, Anders

    2012-01-01

    Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illu

  2. Endothelial function predicts progression of carotid intima-media thickness

    DEFF Research Database (Denmark)

    Halcox, J.P.; Donald, A.E.; Ellins, E.;

    2009-01-01

    investigated endothelial dysfunction, risk factors, and progression of carotid intima-media thickness (cIMT) in late-middle-aged individuals at low to intermediate cardiovascular risk in a prospective study between 1997 and 2005. METHODS AND RESULTS: Brachial artery flow-mediated dilatation and cIMT were...... measured in 213 nonsmoking British civil servants recruited from a prospective cohort (Whitehall II study). Participants (age, 45 to 66 years) were free of clinical cardiovascular disease and diabetes mellitus. Risk factors and Framingham Risk Score were determined at baseline. cIMT was repeated 6...... to its impact on the evolution of the atherosclerotic substrate. Flow-mediated dilatation testing provides an integrated vascular measure that may aid the prediction of structural disease evolution and represents a potential short- to intermediate-term outcome measure for evaluation of preventive...

  3. Vitamin D, carotid intima-media thickness and bone structure in patients with type 2 diabetes

    DEFF Research Database (Denmark)

    Winckler, Karoline; Tarnow, Lise; Lundby-Christensen, Louise;

    2015-01-01

    of diabetes 12±6 years), including 294 patients (71%) treated with insulin. Carotid intima-media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone...

  4. Blood donation, body iron status and carotid intima-media thickness

    NARCIS (Netherlands)

    Engberink, M.F.; Geleijnse, J.M.; Durga, J.; Swinkels, D.W.; Kort, de W.L.A.M.; Schouten, E.G.; Verhoef, P.

    2008-01-01

    Iron could promote free radical formation, which may lead to injury of the arterial wall and atherosclerosis. Blood donation may reduce cardiovascular risk by lowering body iron status. We collected data on blood donation history and intima-media thickness of the common carotid artery (CIMT) in 819

  5. C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study

    Directory of Open Access Journals (Sweden)

    Toprak Ahmet

    2011-12-01

    Full Text Available Abstract Background Conflicting information exists regarding the association between hsCRP and the progression of early stages of atherosclerosis. The purpose of the study was to investigate the association of high sensitiviy c-reactive protein (hsCRP along with major cardiovascular (CV risk factors on early carotid atherosclerosis progression in a large, population-based cohort study. Methods The study cohort included 839 young adults (aged 24 to 43 years, 70% white, 42% men enrolled in Bogalusa Heart Study, who in 2001-2002 attended baseline examination with measurements of CV risk factors. Progression of carotid artery intima-media thickness (IMT was assessed during a mean follow-up of 2.4 years. Results Carotid artery IMT progression rates were as follows: composite carotid artery = 9.2 ± 52 μm/y, common carotid artery = 0.0 ± 51 μm/y, carotid bulb = 8.8 ± 103 μm/y, and internal carotid artery = 18.9 ± 81 μm/y. Elevated baseline hsCRP, reflecting an inflammatory state, showed independent association with composite carotid artery IMT progression. Increased age, systolic blood pressure, fasting glucose, LDL cholesterol, and current smoking were other risk associates of carotid artery IMT progression in young adults, indicating an underlying burden on the CV system by multiple risk factors. Conclusion In this population-based study, we observed independent categorical association of increased hsCRP with carotid artery IMT progression in young adults. This study underlines the importance of assesssing hsCRP levels along with smoking and traditional CV risk factor profiles in asymptomatic young adults.

  6. Carotid plaque, intima-media thickness, and incident aortic stenosis

    DEFF Research Database (Denmark)

    Martinsson, Andreas; Östling, Gerd; Persson, Margaretha;

    2014-01-01

    OBJECTIVE: Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with inciden...

  7. Increased intima-media thickness after early-onset preeclampsia

    NARCIS (Netherlands)

    Blaauw, Judith; van Pampus, Maria G; Van Doormaal, Jasper J; Fokkema, M Rebecca; Fidler, Vaclav; Smit, Andries J; Aarnoudse, Jan G

    2006-01-01

    OBJECTIVE: Preeclampsia is associated with cardiovascular atherosclerotic events later in life. However, little is known about earlier subdinical signs of atherosclerosis. We aimed to investigate whether women who recently had preeclampsia show increased intima-media thickness (IMT), as marker of ea

  8. Carotid intima-media thickness : influence of drug treatment and clinical implications

    NARCIS (Netherlands)

    Ubels, FL; Terpstra, WF; Smit, AJ

    1999-01-01

    With B-mode ultrasound measurements of the intima-media thickness (IMT) of the carotid arterial wall (asymptomatic) atherosclerosis can be detected. In this article several studies are reviewed in which IMT was used as a surrogate endpoint to assess effects of lipid-lowering or antihypertensive drug

  9. Intima-media thickness of the descending aorta in patients with bicuspid aortic valve

    Directory of Open Access Journals (Sweden)

    Johan Petrini

    2016-06-01

    Conclusions: Intima-media thickness of the descending aorta is not affected by aortic valve morphology (BAV/TAV; age is the main determinant of AoIMT. Genetic markers (SNPs known to influence IMT in the carotid artery seem to correlate to IMT in the descending aorta only in patients with TAV.

  10. Comparison of common carotid artery intima-media thickness between Brazilian Euro-descendants and Afro-descendants with atherosclerosis risk factors

    Directory of Open Access Journals (Sweden)

    Ivan Benaduce Casella

    2009-01-01

    Full Text Available OBJECTIVE: To compare common carotid intima-media thickness (IMT between the two major Brazilian ethnic groups (those of African descent and those of European descent among individuals with one or more risk factors for atherosclerotic disease. METHOD: Two hundred and six patients with one or more risk factors for atherosclerotic disease were evaluated in a cross-sectional study in which their clinical, ethnic and Demographic characteristics were collected. All patients underwent duplex ultrasound examination of their carotid vessels to obtain IMT measurements. RESULTS: One hundred and fifty-three patients (74.3% had a carotid IMT greater than 1.0 mm at one or more point of measurement in at least one common carotid artery. There was a significant correlation between older age and mean carotid wall thickness (R=0.479 / P<0.01. Multivariate analysis identified male sex, arterial hypertension and older age as variables associated with increased IMT (P<0.05 for all variables. When IMT was compared between the two ethnic groups in this study, no significant differences were noted. Euro-descendants and Afro-descendants had similar IMT values, even when the groups were stratified by degree of IMT (normal vs. increased and presence of stroke and/or transient ischemic attack (yes vs. no. CONCLUSIONS: The risk factors associated with increased common carotid artery IMT in Brazilian individuals are similar to those in previously described populations. No differences were observed between the two main Brazilian ethnic groups. Longitudinal studies are required for a better evaluation of the incidence, etiologic factors and evolution of carotid intimomedial thickening in this population.

  11. Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease.

    Science.gov (United States)

    Madisetty, Murali Krishna; Kumaraswami, Konda; Katkam, Shivakrishna; Saumya, Kankanala; Satyanarayana Raju, Y; Chandra, Naval; Jyotsna, Maddury; Patnaik, Sujatha; Kutala, Vijay Kumar

    2016-07-01

    We aimed to assess whether measuring carotid intima-media thickness (CIMT) and oxidative stress markers such as protein carbonyls, malondialdehyde, nitrate and glutathione in plasma of elderly patients without and with coronary artery disease (CAD) identifies early risk for CAD. A total of 50 cases with cardiovascular risk factors over the age of 60 years without CAD, and 50 patients with angiographically documented CAD over the age of 60 years were included in the study. Control group consists of 200 healthy individuals without the risk factors. Demographic details were obtained from all the subjects and CIMT measured by high frequency ultrasound and oxidative stress markers such protein carbonyls, malondialdehyde and total glutathione were determined in plasma by spectrophotometric methods. The distribution of cardiovascular risk factors in without CAD and CAD cases were smokers (16 vs 56 %), hypertension (26 vs 64 %), diabetes (16 vs 56 %) and dyslipidemia (18 vs 58 %) and positive family history (4 vs 38 %). None of the control group had any cardiovascular risk factors. Among the CAD cases, 16 % had single vessel disease, 44 % had double vessel disease and 40 % had triple vessel disease. The CIMT was significantly increased in CAD cases as compared to cases without CAD and healthy controls. On the other hand, CIMT was significantly increased in cases without CAD as compared to healthy controls. CIMT also increased with the duration of diabetes in patients without CAD and severity of disease in CAD cases. The levels of oxidants like plasma malondialdehyde, protein carbonyls, were significantly elevated and antioxidant glutathione levels and nitrate levels were significantly reduced in cases with and without CAD as compared to healthy controls. Oxidative stress markers and CIMT was found to be significantly increased in patients with cardiovascular risk factors like diabetes, family history of CAD, dyslipidemia, hypertension and smoking when compared to

  12. Intima-media thickness of carotid artery in middle-aged and old-aged people with different age and sex at nanchang city by ultrasound

    International Nuclear Information System (INIS)

    Objective: To investigate the intima-media thickness (IMT) of carotid artery in middleaged and old-aged people at different age and sex at Nanchang city and to establish the normal reference value. Methods: Excluding coronary heart disease, cerebrovascular disease and diabetes mellitus, 422 patients, above 30 years old were divided into the normal and the control groups based on whether the dangerous factors of atherosclerosis existed or not. Then each group was divided into 5 sub-groups according to age and sex and IMT of carotid artery measurement was perfrmed with ultrasound. Results: Means of IMT of carotid artery becomes higher as the age became older. IMT got predominant thick only when the age was more than 40 in male and 50 in female. Means of IMT is little higher than that in female,but there was no statistical difference between male and female group at age below 39 or above 50. Means of IMT in the control groups were higher than that in the normal groups and the differences was predominant. The ages older, the inner diameters of common carotid arteries wider, and became more predominant wide as the age was more than 50. Compared with female groups, the inner diameters of common carotid arteries of male groups were wider than those in the female groups'. The incidence rate of carotid atherosclerosis plaques was higher as the age became older, but the atherosclerosis plaques was not observed in population below 39 years old. In the population above 40 years old, the incidence rate of carotid atherosclerosis plaques was 5. 06% in the normal groups and 20. 60% in the control groups. No statistic differences exited in the incidence rate of carotid atherosclerosis plaques between the male and female groups. Carotid artery stenosis were observed i. e. five arteries were found in three control patients, and the stenosis degree exceed 50% of the diameter of artery. Conclusions: The IMT of common carotid arteries in the people at age of 40 and above 40 in the

  13. Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Sang Ouk Chin

    2013-10-01

    Full Text Available BackgroundIntima-media thickness (IMT of the carotid arteries is known to have a positive correlation with the risk of cardiovascular disease. This study was designed to identify risk factors affecting the progression of carotid IMT in patients with type 2 diabetes mellitus (T2DM.MethodsPatients with newly diagnosed T2DM with carotid IMT measurements were enrolled, and their clinical data and carotid IMT results at baseline and 2 years later were compared.ResultsOf the 171 patients, 67.2% of males and 50.8% of females had abnormal baseline IMT of the left common carotid artery. At baseline, systolic blood pressure, body mass index and smoking in male participants, and fasting plasma glucose and glycated hemoglobin levels in females were significantly higher in patients with abnormal IMT than in those with normal IMT. Low density lipoprotein cholesterol (LDL-C levels in males and high density lipoprotein cholesterol (HDL-C levels in females at the 2-year follow-up were significantly different between the nonprogression and the progression groups. Reduction of the United Kingdom Prospective Diabetes Study (UKPDS 10-year coronary heart disease (CHD risk score after 2 years was generally higher in the nonprogression group than the progression group.ConclusionLDL-C levels in males and HDL-C levels in females at the 2-year follow-up were significantly different between participants with and without progression of carotid IMT. Furthermore, a reduction in the UKPDS 10-year CHD risk score appeared to delay the advancement of atherosclerosis. Therefore, the importance of establishing the therapeutic goal of lipid profiles should be emphasized to prevent the progression of carotid IMT in newly diagnosed T2DM patients.

  14. Oxidative damage markers are significantly associated with the carotid artery intima-media thickness after controlling for conventional risk factors of atherosclerosis in men.

    Directory of Open Access Journals (Sweden)

    Jin-Ha Yoon

    Full Text Available This study aimed to assess the association between oxidative damage markers and carotid artery intima-media thickness (CIMT after controlling for conventional risk factors of atherosclerosis in multiple logistic regression models.Fifty-one case male participants (CIMT ≥ 0.9 mm were enrolled during their visits to Korean Genomic Rural Cohort Study of Wonju centers between May 1 and August 31, 2011, along with 51 control participants (CIMT < 0.9 mm selected using frequency matching by age group. The levels of oxidative damage markers, 8-hydroxy-2'-deoxyquuanosine (8-OHdG, malondialdehyde (MDA, and 8-iso-prostaglandin F2α (Isoprostane, were measured. Conditional logistic regression models were used to evaluate relative relationships between the oxidative damage markers and the risk of high CIMT.The markers of oxidative lipid (Isoprostane and MDA and DNA (8-OHdG damage were associated with CIMT after controlling for the conventional risk factors, including age, low density lipoprotein, body mass index, smoking history, alcohol consumption, and metabolic syndrome (ORs [95% CI] for Isoprostane: 3rd tertile, 8.47 [2.59-27.67]; for MDA: 3rd tertile, 8.47 [2.59-27.67]; for 8-OHdG: 3rd tertile, 5.58 [1.79-17.33]. When all the oxidative damage markers were incorporated in the same logistic regression model, only Isoprostane was significantly related to CIMT (OR [95% CI]: 4.22 [1.31-13.53] in 2nd tertile and 14.21 [3.34-60.56] in 3rd tertile.In this nested case-control study, the oxidative damage markers of lipid and DNA were associated with CIMT even after controlling for the conventional risk factors of cardiovascular diseases.

  15. The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients.

    Science.gov (United States)

    Lee, Guo-She; Lee, Li-Ang; Wang, Chao-Yung; Chen, Ning-Hung; Fang, Tuan-Jen; Huang, Chung-Guei; Cheng, Wen-Nuan; Li, Hsueh-Yu

    2016-01-01

    Obstructive sleep apnea (OSA) is a known risk factor for atherosclerosis. We investigated the association of common carotid artery intima-media thickness (CCA-IMT) with snoring sounds in OSA patients. A total of 30 newly diagnosed OSA patients with no history of cardiovascular diseases were prospectively enrolled for measuring mean CCA-IMT with B-mode ultrasonography, body mass index, metabolic syndrome, 10-year cardiovascular disease risk score, high-sensitivity C-reactive protein, and homocysteine. Good-quality signals of full-night snoring sounds in an ordinary sleep condition obtained from 15 participants were further acoustically analyzed (Included group). All variables of interest were not significantly different (all p > 0.05) between the included and non-included groups except for diastolic blood pressure (p = 0.037). In the included group, CCA-IMT was significantly correlated with snoring sound energies of 0-20 Hz (r = 0.608, p = 0.036) and 652-1500 Hz (r = 0.632, p = 0.027) and was not significantly associated with that of 20-652 Hz (r = 0.366, p = 0.242) after adjustment for age and sex. Our findings suggest that underlying snoring sounds may cause carotid wall thickening and support the large-scale evaluation of snoring sound characters as markers of surveillance and for risk stratification at diagnosis. PMID:27469245

  16. The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients

    Science.gov (United States)

    Lee, Guo-She; Lee, Li-Ang; Wang, Chao-Yung; Chen, Ning-Hung; Fang, Tuan-Jen; Huang, Chung-Guei; Cheng, Wen-Nuan; Li, Hsueh-Yu

    2016-01-01

    Obstructive sleep apnea (OSA) is a known risk factor for atherosclerosis. We investigated the association of common carotid artery intima-media thickness (CCA-IMT) with snoring sounds in OSA patients. A total of 30 newly diagnosed OSA patients with no history of cardiovascular diseases were prospectively enrolled for measuring mean CCA-IMT with B-mode ultrasonography, body mass index, metabolic syndrome, 10-year cardiovascular disease risk score, high-sensitivity C-reactive protein, and homocysteine. Good-quality signals of full-night snoring sounds in an ordinary sleep condition obtained from 15 participants were further acoustically analyzed (Included group). All variables of interest were not significantly different (all p > 0.05) between the included and non-included groups except for diastolic blood pressure (p = 0.037). In the included group, CCA-IMT was significantly correlated with snoring sound energies of 0–20 Hz (r = 0.608, p = 0.036) and 652–1500 Hz (r = 0.632, p = 0.027) and was not significantly associated with that of 20–652 Hz (r = 0.366, p = 0.242) after adjustment for age and sex. Our findings suggest that underlying snoring sounds may cause carotid wall thickening and support the large-scale evaluation of snoring sound characters as markers of surveillance and for risk stratification at diagnosis. PMID:27469245

  17. Atherosclerosis in rheumatoid arthtritis: the role of high-resolution B mode ultrasound in the measurement of the arterial intima-media thickness

    Directory of Open Access Journals (Sweden)

    G.M. Giuseppetti

    2011-09-01

    Full Text Available Background: Patients with rheumatoid arthritis (RA have a reduced life expectancy and high cardiovascular morbidity and mortality as compared to the general population. A number of possible factors for the atherogenesis in this disease have been described, such as homocysteine, altered serum levels of selected lipopotroteins and treatment. Recent findigs indicate that the systemic inflammation may contribute to the development of atherosclerosis and confer an additional risk for cardiovascular death among patients with RA. The aim of our study was to evaluate the ability of high resolution Bmode ultrasoud and color Doppler to assess the existence of subclinical atherosclerosis in RA patients, measuring the intima- media thickness (IMT and resistence index of the common carotid arteries. Methods: Carotid IMT and carotid plaque were measured using high-resolution B-mode ultrasound in 40 patients with RA and 40 age- and sex-matched healthy persons. We used color Doppler ultrasound to assess vascular damage of the common carotid arteries and the resistence index (RI was determined by analysis of the spectral waveforms. Serum total cholesterol, trygliceridies, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, rheumatoid factor, body mass index (BMI, visual analogue scale (VAS were determined in patients and controls. C-reactive protein (CRP and the DAS28 were used to measure systemic inflammation. Results: Common carotid IMT were significantly higher (p=0.0009 in RA patients (0.83 ± 0.23 compared with controls (0.66 ± 0.22. In RA patients common carotid IMT was significantly correlated with serum total cholesterol (p=0.0008, low-density lipoprotein cholesterol (p=0.006, trygliceridies (p=0.042, age (p=0.031 and disease duration (p=0.019. No significant correlation was found with clinical and laboratory parameters reflecting disease activity. The prevalence of plaques was higher in RA patients compared with controls (25% vs

  18. Effect of intensive multifactorial treatment on the intima-media thickness of large arteries in patients with new-onset type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    Xiao-hong ZHAO; Zhe-rong XU; Qin ZHANG; Hai-feng GU; Yun-mei YANG

    2012-01-01

    Objective:To quantify the changes in blood glucose,blood lipids,blood pressure,and the intima-media thickness (IMT) of large arteries in patients with new-onset type 2 diabetes mellitus who received either intensive multifactorial treatment or conventional treatment.Methods:Two-hundred and ten patients with new-onset type 2 diabetes mellitus were randomly assigned to two groups:an intensive treatment group (n=110) and a conventional treatment group (n=100).Fasting blood glucose (FBG),glycosylated hemoglobin A1c (HbA1c),blood pressure,blood lipids [total cholesterol (TC),triolyceride (TG),low-density lipoprotein C (LDL-C),and high-density lipoprotein C (HDL-C)],and IMTs of large arteries (carotid,iliac,and femoral arteries) were determined before and at one and two years after starting treatment.The patients in the conventional treatment group received routine diabetes management in our outpatient department.Targets were established for patients in the intensive treatment group.Their blood glucose,blood lipids,and blood pressure levels were regularly monitored and therapeutic regimens were adjusted for those whose measurements did not meet the target values until all the parameters met the established targets.Within-group and between-group differences were evaluated.Results:A significantly greater percentage of patients in the intensive treatment group had LDL-C levels that reached the target value one year after starting treatment than those in the conventional treatment group (52.04% vs.33.33%,P<0.05).No significant differences were found between groups for FBG,HbA1c,blood pressure,TG,TC,or HDL-C.The percentages of patients with TG (51.02% vs.34.48%),TC (52.04% vs.33.33%),and LDL-C (61.22% vs.43.67%) who met the respective target values in the intensive treatment group were all significantly higher than the corresponding percentages in the conventional treatment group two years after starting treatment (P<0.05).There were no significant

  19. Carotid intima-media thickness: a target or a marker?

    Science.gov (United States)

    Montalcini, Tiziana; Romeo, Stefano; Fava, Antonietta; Pujia, Arturo

    2014-01-01

    Evidence-based medicine requires us to use pharmacological agents that have been tested and that have been showed to reduce the disease in that particular group of affected patients. The choice of the efficacy endpoint is one of the most controversial issues in designing the trials. To reduce the high economic costs resulting by the large-scale trials design and implementation, the substitution of the primary endpoints with a surrogate one, is an optimal opportunity. Carotid intima-media thickness is considered an excellent predictor of cardiovascular events, and it is also seen as a perfect model of surrogate endpoint for pharmacological studies. However, the results from studies using it as a surrogate endpoints could lead to erroneous conclusions and could lead marketing of products with limited or doubt effectiveness on cardiovascular prevention. Studies showed that many interventions targeting the Carotid intima-media thickness not impact the final clinical endpoints of interest, whereas low-density lipoprotein cholesterol level is an excellent biomarker because it can predict the cardiovascular outcomes and interventions therapy can efficaciously reduce it. PMID:23011174

  20. Relation between food and drinking habits, and skin autofluorescence and intima media thickness in subjects at high cardiovascular risk

    NARCIS (Netherlands)

    Jochemsen, B. M.; Van Doormaal, J. J.; Mulder, G.; Volmer, M.; Graaff, R.; Smit, A. J.; Mulder, Douwe J.

    2009-01-01

    We investigated the relations between food and drinking habits, and estimated exogenous advanced glycation end products (AGE) intake, skin autofluorescence (AF) as a marker of AGE accumulation, and intima media thickness (IMT). IMT of the carotid artery and skin AF were measured in 147 elderly subje

  1. Carotid intima media thickness is independently associated with urinary sodium excretion in patients with chronic kidney disease.

    Science.gov (United States)

    Ustundag, Sedat; Yilmaz, Gulay; Sevinc, Can; Akpinar, Seval; Temizoz, Osman; Sut, Necdet; Ustundag, Ayten

    2015-01-01

    Atherosclerosis-induced premature vascular diseases are the leading cause of mortality among patients with chronic kidney disease (CKD). The pathogenetic mechanism of atherosclerosis in patients with CKD has not been fully explained. Experimental studies have demonstrated that high dietary sodium intake not only increases circulatory volume and blood pressure, but also facilitates development of atherosclerosis by reducing production-bioavailability of nitric oxide due to oxidative stress and accordingly by enhancing endothelial and arterial stiffness. In this study, we investigated the relationship between sodium consumption and carotid artery intima-media thickness, which is the indicator of atherosclerosis, by determining daily urinary sodium excretion, which is a reliable indicator of sodium consumption, in our patient group. Our patient group included 193 patients with stage 2-4 non-diabetic CKD and without a history of atherosclerotic disease. We determined that 77% of our patients have been consuming more than 2  g of sodium per day, which is the upper limit of sodium consumption recommended for patients with CKD. We determined a positive linear correlation between carotid artery intima-media thickness and patient age (p mass index (p = 0.002), systolic blood pressure (p = 0.002), hemoglobin (p = 0.030), triglycerides (p = 0.043), and diastolic blood pressure (p = 0.049). We also found a negative linear correlation between carotid artery intima-media thickness and glomerular filtration rate (p = 0.008). We found that urinary sodium excretion is the determinant of intima-media thickness even if all factors associated with intima-media thickness are adjusted, and that intima-media thickness increases by 0.031 (0.004-0.059) mm per 2  g increase in daily sodium excretion, independent from overall factors (p = 0.025). Our results reveal a relation between urinary sodium excretion and carotid artery intima-media thickness and

  2. RELATIONSHIP BETWEEN PSYCHOEMOTIONAL DISORDERS WITH INCREASING THICKNESS OF INTIMA-MEDIA COMPLEX AND VASCULAR MICRO INFLAMMATION DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2011-01-01

    Full Text Available Objective — to study relationship of psycho-emotional factors and indicators of intravascular microinflammation and vascular changes in healthy patients.Materials and methods. To study psycho-emotional status in 239 healthy patients aged 30 to 60 years, markers of inflammation (C-reactiveprotein — CRP and cytokines — tumor necrosis factor-α — TNF-α, interleukins — IL-1, -4, - 8 and ultrasonography of the vascular wall of the common carotid artery with the definition of the thickness of intimamedia.Results. In group with high levels of emotional stress significant increase in the thickness of intima media and increase in plasma concentrationsof markers of vascular mikrovospaleniya — CRP, IL-1, IL-8, TNF-α were showed. These correlation analysis indicated relationship between thickness of intima-media, psychoemotional factors and markers of vascular microinflamation. Calculating odds ratios revealed that thickening of the intima-media process such psycho-emotional disorders like anxiety, depression and fatigue are of great importance.Conclusion. Otherwise development of latent intravascular inflammation and thickening intima-media complex of common carotid artery is registered inhealthy patients with presence of psycho-emotional disorders (depression, anxiety, fatigue.

  3. Differences in left and right carotid intima-media thickness and the associated risk factors

    International Nuclear Information System (INIS)

    Aim: To investigate the difference between the left and right carotid artery intima-media thickness (CIMT) with increasing age and to analyse the importance of the various risk factors associated with left and right CIMT, respectively. Materials and methods: Four hundred and forty-seven people were assigned into six groups based on age. CIMT and haemodynamic parameters of both carotid arteries were measured using the Quality Intima-Media Thickness (QIMT) technique. In addition, biochemical and anthropometric indices were also measured. Their associations were evaluated using simple and partial correlation analysis, adjusted for age. Results: Bilateral CIMTs became thicker with age (p < 0.001) and the left CIMT was significantly thicker compared with the right between the ages of 35 and 65 years (p = 0.01-0.05). In addition, the right CIMT thickened 10 years later compared with the left. Partial correlation analysis showed that the right CIMT correlated better with haemodynamic parameters compared with the left CIMT, but the left CIMT showed better correlation with biochemical indices. Conclusion: Haemodynamic and biochemical changes had different effects on the CIMT depending on the side affected. In addition, the left CIMT was thicker than the right between the ages of 35 and 65 years old.

  4. Intima-Media Thickness Measurements in the Fetus and Mother During Pregnancy

    DEFF Research Database (Denmark)

    Galjaard, Sander; Pasman, Suzanne A; Ameye, Lieveke;

    2014-01-01

    Fetal intima-media thickness (IMT) has been suggested as a marker of pre-clinical atherosclerosis, and maternal IMT could be altered through dynamic circumstances related to pregnancy. We investigated the feasibility of measurement of IMT at four pre-defined fetal and four pre-defined maternal...... arterial locations to determine vascular changes that could be associated with impaired vascular function. IMT was measured from the first to third trimester (12-34 wk), in 38 low-risk pregnancies. We imaged a 10-mm region of interest using a Mindray (Shenzhen, China) high-resolution ultrasound machine...... pregnancy. There was a significant relation between gestational age and IMT in the umbilical artery (p = 0.03) and a significant relation between body mass index and IMT in the maternal common carotid artery (p = 0.01). IMT measurements are feasible in some maternal and fetal vessels of interest. Further...

  5. Carotid intima-media thickness in the spanish population : reference ranges and association with cardiovascular risk factors

    OpenAIRE

    Grau, M; Subirana, I.; Agis, D.; Ramos, R.; Basagana, X; Marti, R.; Groot, E. de; Arnold, R.J.; Marrugat, J.; Künzli, N.; Elosua, R.

    2012-01-01

    INTRODUCTION AND OBJECTIVES: Carotid intima-media thickness as measured with ultrasonography is an inexpensive and noninvasive predictor of cardiovascular events. The objectives of this study were to determine the population reference ranges of carotid intima-media thickness for individuals aged 35-84 years in Spain and to analyze the association of carotid intima-media thickness with cardiovascular risk factors (age, smoking, diabetes, pulse pressure, lipid profile, and body mass index). MET...

  6. Relationship Between CarotidIntima-Media Thickness and Silent Cerebral Infarction in Japanese Subjects With Type 2 Diabetes

    OpenAIRE

    Nomura, Kazuhiro; Hamamoto, Yoshiyuki; Takahara, Shiho; Kikuchi, Osamu; Honjo, Sachiko; Ikeda, Hiroki; Wada, Yoshiharu; Nabe, Koichro; Okumra, Ryosuke; Koshiyama, Hiroyuki

    2009-01-01

    OBJECTIVE We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS The brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive Japanese subjects with type 2 diabetes. Various risk factors for SCI were examined using multiple logistic analyses. RESULTS The SCI was fo...

  7. Estimation of prenatal aorta intima-media thickness from ultrasound examination

    Science.gov (United States)

    Veronese, E.; Tarroni, G.; Visentin, S.; Cosmi, E.; Linguraru, M. G.; Grisan, E.

    2014-10-01

    Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data. The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed. Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%). The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT. Preliminary results have been presented in E Veronese, E Cosmi, S Visentin, E Grisan: 'Semiautomatic estimation

  8. Estimation of prenatal aorta intima-media thickness from ultrasound examination

    International Nuclear Information System (INIS)

    Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data. The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed. Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%). The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT. (paper)

  9. Carotid intima-media thickness in individuals with and without type 2 diabetes

    DEFF Research Database (Denmark)

    Lundby-Christensen, Louise; Almdal, Thomas P; Carstensen, Bendix;

    2010-01-01

    BACKGROUND: The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type 2 diabetes (T2D). Even though knowledge about methodology is of highest...... importance in order to make accurate power calculations and analyses of results, no reproducibility studies have been performed in this group of patients. The aim of this study was to quantify the variability of the measurement of carotid IMT in individuals with and without T2D. METHODS: We used B......-mode ultrasound and a computerized software programme (MIA vascular tools) for analysis of carotid IMT. Measurement of carotid IMT in the far wall of the common carotid artery (CCA) was done for 30 patients with T2D and 30 persons without T2D. The examinations were done by two different sonographers and two...

  10. Early and current physical activity: relationship with intima-media thickness and metabolic variables in adulthood

    Directory of Open Access Journals (Sweden)

    Manoel C. S. Lima

    2014-10-01

    Full Text Available Background: It is unclear whether early physical activity has a greater influence on intima-media thickness and metabolic variables than current physical activity. Objective: To analyze the relationship between current and early physical activity, metabolic variables, and intima-media thickness measures in adults. Method: The sample was composed of 55 healthy subjects of both sexes (33 men and 22 women. Total body fat and trunk fat were estimated by dual-energy X-ray absorptiometry. Carotid and femoral intima-media thickness were measured using a Doppler ultrasound device. A 12-hour fasting blood sample collection was taken (fasting glucose and lipid profile. Early physical activity was assessed through face-to-face interview, and the current physical activity was assessed by pedometer (Digi-Walker Yamax, SW200, which was used for a period of seven days. Results: Current physical activity was negatively related to total cholesterol (rho=-0.31, while early physical activity was negatively related to triglycerides (rho=-0.42, total cholesterol (rho=-0.28, very low density lipoprotein (rho=-0.44, and carotid intima-media thickness (rho=-0.50. In the multivariate model, subjects engaged in sports activities during early life had lower values of very low density lipoprotein (b=-8.74 [b=-16.1; -1.47] and carotid intima-media thickness (b=-0.17 [95%CI: -0.28; -0.05]. Conclusion: Early 95%CI physical activity has a significant influence on carotid intima-media thickness, regardless of the current physical activity.

  11. Association between microalbuminuria and subclinical atherosclerosis evaluated by carotid artery intima-media in elderly patients with normal renal function

    OpenAIRE

    Kong XiangLei; Jia XiaoYan; Wei Yong; Cui MeiYu; Wang ZunSong; Tang LiJun; Li WenBin; Zhu ZhuXian; Chen Ping; Xu DongMei

    2012-01-01

    Abstract Background Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, little is known about the direct association between subclinical atherosclerosis evaluated by carotid artery intima-media thickness (IMT) and microalbuminuria in elderly patients with normal renal function. Methods Subjects were 272 elderly patients (age  ≥ 60 years) with normoalbuminuria (n = 238) and microalbuminuria (n = 34). Carotid IMT wa...

  12. Does carotid intima-media thickness have relationship with polycystic ovary syndrome?

    Directory of Open Access Journals (Sweden)

    Zahra Allameh

    2013-01-01

    Full Text Available Background: Polycystic ovary syndrome (PCOS is a common reproductive endocrine disorder associated with cardiovascular disease (CVD risk factors and metabolic disturbances and a genetically heterogeneous disease. Intima-media thickness (IMT is an indicator of atherosclerosis. This study aimed to determine the relation between IMT and PCOS in women. Methods: This cross-sectional study was performed on 44 PCOS patients and 44 healthy women. Data collection included lipid profiles, blood pressure, waist circumference, body mass index (BMI, and common and internal IMT of carotid artery which were measured in studied subjects. IMT was measured by a radiologist using a linear 12 MHz ultrasound probe (LOGIC S6, GE in carotid setting. Results: IMT of common carotid artery (56.8 ΁ 7.6 in cases versus 49.8 ΁ 7.3 in controls, internal carotid artery (56.9 ΁ 6.03 in cases versus 49.6 ΁ 6.9 in controls, and both common and internal carotid artery (56.6 ΁ 6.7 in cases versus 49.7 ΁ 6.9 in controls were significantly higher in PCOS patients than healthy women (P < 0.001. Conclusions: In summary, results demonstrated that carotid artery thickness as a risk for premature atherosclerosis in patients with PCOS is higher than healthy subjects. And hence care and monitoring of PCOS women with these risk factors sounds to be important and necessary.

  13. Acute change in vascular tone alters intima-media thickness

    NARCIS (Netherlands)

    Thijssen, D.H.J.; Scholten, R.R.; Munckhof, I.C. van den; Benda, N.M.M.; Green, D.J.; Hopman, M.T.E.

    2011-01-01

    Atherosclerosis is a lifelong process involving artery wall thickening. Increased wall thickness has been widely adopted as a preclinical surrogate marker of atherosclerosis. A prerequisite for such a surrogate marker is that it is a structural characteristic of the vessel wall that is not subject t

  14. Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

    NARCIS (Netherlands)

    Eikendal, Anouk L. M.; Groenewegen, Karlijn A.; Anderson, Todd J.; Britton, Annie R.; Engstrom, Gunnar; Evans, Greg W.; de Graaf, Jacqueline; Grobbee, Diederick E.; Hedblad, Bo; Holewijn, Suzanne; Ikeda, Ai; Kitagawa, Kazuo; Kitamura, Akihiko; Lonn, Eva M.; Lorenz, Matthias W.; Mathiesen, Ellisiv B.; Nijpels, Giel; Dekker, Jacqueline M.; Okazaki, Shuhei; O'Leary, Daniel H.; Polak, Joseph F.; Price, Jacqueline F.; Robertson, Christine; Rembold, Christopher M.; Rosvall, Maria; Rundek, Tatjana; Salonen, Jukka T.; Sitzer, Matthias; Stehouwer, Coen D. A.; Hoefer, Imo E.; Peters, Sanne A. E.; Bots, Michiel L.; den Ruijter, Hester M.

    2015-01-01

    Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 year

  15. Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

    NARCIS (Netherlands)

    Persson, Jonas; Strawbridge, Rona J.; McLeod, Olga; Gertow, Karl; Silveira, Angela; Baldassarre, Damiano; Van Zuydam, Natalie; Shah, Sonia; Fava, Cristiano; Gustafsson, Stefan; Veglia, Fabrizio; Sennblad, Bengt; Larsson, Malin; Sabater-Lleal, Maria; Leander, Karin; Gigante, Bruna; Tabak, Adam; Kivimaki, Mika; Kauhanen, Jussi; Rauramaa, Rainer; Smit, Andries J.; Mannarino, Elmo; Giral, Philippe; Humphries, Steve E.; Tremoli, Elena; de Faire, Ulf; Lind, Lars; Ingelsson, Erik; Hedblad, Bo; Melander, Olle; Kumari, Meena; Hingorani, Aroon; Morris, Andrew D.; Palmer, Colin N. A.; Lundman, Pia; Ohrvik, John; Soderberg, Stefan

    2015-01-01

    Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influ

  16. Manual B-Mode Versus Automated Radio-Frequency Carotid Intima-Media Thickness Measurements

    NARCIS (Netherlands)

    S. Dogan; Y. Plantinga; J.M. Dijk; Y. van der Graaf; D.E. Grobbee; M.L. Bots

    2009-01-01

    Background: Carotid intima-media thickness (CIMT) serves as an indicator of atherosclerosis and cardiovascular risk. Manual measurements of B-mode ultrasound images are the most applied method. Automated measurements with radiofrequency (RF) ultrasound have been suggested as an alternative. The aim

  17. Follow up of intima-media thickness after severe early-onset preeclampsia

    NARCIS (Netherlands)

    Blaauw, Judith; Souwer, Esteban T D; Coffeng, Sophie M; Smit, Andries J; van Doormaal, Jasper J; Faas, Marijke M; van Pampus, Maria G

    2014-01-01

    OBJECTIVE: Early-onset preeclampsia is associated with premature cardiovascular disease. We previously demonstrated that femoral intima-media thickness (IMT) and markers of cardiovascular disease were increased in women 1 year after early-onset preeclampsia. The current study measured (progression o

  18. Progression of carotid intima media thickness after radiotherapy: A long-term prospective cohort study

    International Nuclear Information System (INIS)

    Background and purpose: Carotid artery vasculopathy is a long-term complication of radiotherapy (RT) of the neck. We investigated the change in carotid intima media thickness (IMT) and the incidence of ischemic stroke in the first 7 years after radiotherapy (RT) of the neck. Materials and methods: A multicentre prospective cohort study among patients treated for Head and Neck Cancer (HNC) assessed carotid IMT at baseline (before RT) and after a median of 7 years follow-up. We also screened for cerebrovascular risk factors and events. Results: 48 patients underwent IMT measurement at baseline and follow-up (median age 61 years, range 29–87). Mean IMT of the irradiated common carotid arteries was 0.64 mm at baseline and 0.74 mm at follow-up (p = 0.002). Mean delta IMT in the irradiated and non-irradiated common carotid arteries were 0.11 and 0.02 mm (p = 0.03). Incidence rate of stroke in our cohort, compared to the Dutch population was 8.9 versus 1.5 per 1.000 person years. Conclusions: IMT in irradiated carotid arteries was significantly increased in the first 7 years after RT. The incidence rate of stroke was six fold increased. Patients treated with RT for HNC have sustained risk for developing atherosclerosis of the carotid arteries and future stroke

  19. Relationship between carotid intima-media thickness and coronary angiographic findings: a prospective study

    Directory of Open Access Journals (Sweden)

    Kilickesmez Kadriye O

    2009-12-01

    Full Text Available Abstract Background Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT is a non-invasive marker of coronary artery disease (CAD and is widely used in practice as an inexpensive, reliable, and reproducible method. In the current study, we aimed to investigate prospectively the relationship of CIMT with the presence and extent of significant coronary artery narrowing in patients evaluated by coronary angiography for stable angina pectoris. Methods One hundred consecutive patients with stable angina pectoris and documented ischemia on a stress test were included in the study. The patients were divided into two groups according to the result of the coronary angiography: group 1 (39 patients without a noncritical coronary lesion, and group 2 (61 patients having at least one lesion more than 50% within the main branches of the coronary arteries. All of the patients underwent carotid Doppler ultrasound examination for measurement of the CIMT by a radiologist blinded to the angiographic data. Results The mean CIMT was 0.78 ± 0.21 mm in Group 1, while it was 1.48 ± 0.28 mm in Group 2 (p = 0.001. The mean CIMT in patients with single vessel disease, multi-vessel disease, and left main coronary artery disease were significantly higher compared to Group 1 (1.2 ± 0.34 mm, p = 0.02; 1.6 ± 0.32 mm, p = 0.001; and 1.8 ± 0.31 mm, p = 0.0001, respectively. Logistic regression analysis identified CIMT (OR 4.3, p Conclusions The findings of this study show that increase in CIMT is associated with the presence and extent of CAD. In conclusion, we demonstrated the usefulness of carotid intima-media thickness in predicting coronary artery disease but large-scale studies are required to define its role in clinical practice.

  20. Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: Role of CETP and triglycerides

    NARCIS (Netherlands)

    R. de Vries (Rindert); F.G. Perton (Frank G.); G.M. Dallinga-Thie (Geesje); A.M.M. van Roon (Arie); B.H.R. Wolffenbuttel (Bruce); A. van Tol (Arie); R.P.F. Dullaart (Robin)

    2005-01-01

    textabstractWe tested whether carotid artery intima-media thickness (IMT) is associated with plasma cholesteryl ester transfer (CET) and/or the plasma cholesteryl ester transfer protein (CETP) concentration in type 2 diabetic and control subjects. In 87 male and female subjects with type 2 diabetes

  1. Lower carotid intima media thickness is predicted by higher serum bilirubin in both non-diabetic and Type 2 diabetic subjects

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; Kappelle, Paul J. W. H.; de Vries, Rindert

    2012-01-01

    Background: Higher serum bilirubin levels may be implicated cardiovascular protection. It is unknown whether the impact of serum bilirubin on carotid artery intima media thickness (IMT), a marker of subclinical atherosclerosis, is different in diabetic subjects compared to non-diabetic subjects. We

  2. Evaluation of intima media thickness of carotid arteries in 40-60 years old persons with type d personality and its comparison with normal ones

    Directory of Open Access Journals (Sweden)

    Fariborz Khorvash

    2013-01-01

    Conclusions: We conclude that type D personality increases the risk of cardiovascular diseases specially the stroke and myocardial infarction due to the higher prevalence of hormonal imbalances leading to arterial vasospasm and atherosclerotic disease. As a result, it is necessary to evaluate and treat these patients due to increased risk of atherosclerotic diseases, stoke, and myocardial infarction.

  3. Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Troelsen, Lone N; Garred, Peter; Christiansen, Buris;

    2010-01-01

    high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients. METHODS: In a cross-sectional study...... MBL2 genotypes and serum concentrations of MBL were assessed; ccIMT was determined by means of ultrasonography; traditional and RA related cardiovascular risk modifiers were measured. RESULTS: The median ccIMT was 0.67 mm. The investigated MBL2 genotypes were not significantly associated with cc...

  4. Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas

    Directory of Open Access Journals (Sweden)

    Giuseppe Reimondo

    2015-01-01

    Full Text Available Purpose. The aim of the present study was to investigate the atherosclerotic vascular damage in a consecutive series of patients with AI and to correlate it with MSC. Methods. We studied 32 patients with AI matched with control subjects for age, sex, and cardiovascular risk factors. Either patients or control subjects underwent MSC measurement as outpatients and carotid arteries ultrasound (US imaging studies. Results. The patients with AI had higher mean carotid artery IMT values and higher MSC levels than control subjects. In a multivariate analysis performed in AI age was the best predictor for IMT. We have stratified patients and control subjects by age (<60 yrs and ≥60 yrs. The patients showed significantly higher MSC levels than controls in both groups, whereas significantly higher IMT values were observed only in older subjects. Conclusions. Patients with AI have signs of accelerated atherosclerosis. Patients older than 60 years seem more susceptible to the possible detrimental effect of subclinical hypercortisolism on cardiovascular system. The MSC levels are not a strong predictor of the accelerated atherosclerosis, but they seem to indicate the subtle but not autonomous cortisol excess that may potentially raise the cardiovascular risk.

  5. Carotid intima-media thickness and elastic properties of aortas in normotensive children of hypertensive parents.

    Science.gov (United States)

    Yildirim, Ali; Kosger, Pelin; Ozdemir, Gokmen; Sahin, Fezan Mutlu; Ucar, Birsen; Kilic, Zubeyir

    2015-09-01

    A significant correlation between hypertension history and high blood pressure has been observed with regard to age, race and gender. Investigating carotid intima-media thickness and aortic stiffness prior to the development of hypertension in children of hypertensive parents enabled us to evaluate these patients for subclinical atherosclerosis. We compared carotid intima-media thickness, aortic strain, distensibility, stiffness indices and elastic modulus in 67 normotensive children whose parents had a diagnosis of essential hypertension and 39 normotensive children with no parental history of hypertension. Although there were no significant differences between the two groups in terms of systolic blood pressure, diastolic blood pressure, average blood pressure and pulse pressure (P>0.05), systolic blood pressures were higher among patients 15 years and older in the study group. No significant differences were noted between the control and study groups regarding interventricular septal thickness, left-ventricular posterior wall thickness, left-ventricular systolic and diastolic diameter and aortic annulus diameter (P>0.05). The left atrium diameter was larger in the study group compared with that in the control group, mainly because of the values of the 15-year-old and older children (P=0.01). The mean, maximum and minimum values of carotid intima-media thickness were significantly different in the study group compared with the control group among all age groups (Pchildren of hypertensive parents compared with the control group (P=0.014, P=0.001, respectively). Although there were no differences between the study and control groups regarding aortic strain, aortic distensibility, elastic modulus and stiffness indices (P>0.05), aortic distensibility was lower, and aortic stiffness indices were higher among children 15 years and older in the study group. An increase in the carotid intima-media thickness in all age groups and a decrease in aortic elastic properties in

  6. Carotid Artery Intima-Media Thickness and Cutaneous Microvascular Function are Associated With Vitamin C Levels in Young Patients With Type 1 Diabetes

    DEFF Research Database (Denmark)

    Odermarsky, Michal; Lykkesfeldt, Jens; Liuba, Petru

    2008-01-01

    Background: Vascular endothelial dysfunction and accelerated thickening of arterial intima contribute to increased cardiovascular morbidity in type 1 diabetes. Although vitamin C has important antioxidant functions, and increased oxidative stress is a central mechanism of vascular abnormalities......, and the measured skin perfusion was expressed as % maximal increase from baseline. Markers of systemic inflammation (C-reactive protein, fibrinogen and orosomucoid), lipids (total, LDL and HDL cholesterol) and glycosylated hemoglobin (HbA1c) were measured in EDTA plasma. Ascorbate was analyzed in meta......-phosphoric acid-stabilized EDTA-plasma by high-performance liquid chromatography. Results: In univariate regression analysis, both cIMT and skin microvascular response to ACH correlated with ascorbate levels (r=-0.29; p=0.04, and r=0.43; p=0.004 respectively). The relationships between these vascular indexes...

  7. Effects of Nitric Oxide on Carotid Intima Media Thickness: A Pilot Study.

    Science.gov (United States)

    Lee, Edwin

    2016-06-01

    Cardiovascular disease is among the leading causes of morbidity and mortality worldwide. Preventive treatment of high-risk asymptomatic individuals depends on accurate prediction of a person's risk to develop a cardiovascular event. Currently, cardiovascular risk prediction in asymptomatic individuals is based on the level of cardiovascular risk factors incorporated in scoring equations. Improvement in cardiovascular risk prediction is needed because atherosclerosis underlies the occurrence of cardiovascular events, develops over decades, and has a prolonged asymptomatic phase during which it is possible to modify the course of the disease. The carotid intima media thickness test (CIMT) is a measure used to diagnose the extent of carotid atherosclerotic vascular disease. The test measures the thickness of the inner 2 layers of the carotid artery-the intima and media-and alerts physicians to any thickening when patients are still asymptomatic. Early detection may indicate the need for a more aggressive approach to managing the risk factors associated with heart disease and stroke. The role of nitric oxide (NO) in maintaining the integrity of the cardiovascular system is well established. Utilizing a dietary supplement that restores NO production, the author conducted a pilot study involving 10 patients with stable plague. Six months of treatment with the NO lozenge resulted in a statistically significant 10.9% reduction in CIMT. This pilot study suggests this approach may be a safe and effective strategy for patients with early stages of atherosclerotic vascular disease.

  8. Carotid wall stress calculated with continuous intima-media thickness assessment using B-mode ultrasound

    Science.gov (United States)

    Pascaner, A. F.; Craiem, D.; Casciaro, M. E.; Danielo, R.; Graf, S.; Guevara, E.

    2016-04-01

    Cardiovascular risk is normally assessed using clinical risk factors but it can be refined using non-invasive infra-clinical markers. Intima-Media Thickness (IMT) is recognized as an early indicator of cardiovascular disease. Carotid Wall Stress (CWS) can be calculated using arterial pressure and carotid size (diameter and IMT). Generally, IMT is measured during diastole when it reaches its maximum value. However, it changes during the cardiac cycle and a time-dependant waveform can be obtained using B-mode ultrasound images. In this work we calculated CWS considering three different approaches for IMT assessment: (i) constant IMT (standard diastolic value), (ii) estimated IMT from diameter waveform (assuming a constant cross-sectional wall area) and (iii) continuously measured IMT. Our results showed that maximum wall stress depends on the IMT estimation method. Systolic CWS progressively increased using the three approaches (p<0.024). We conclude that maximum CWS is highly dependent on wall thickness and accurate IMT measures during systole should be encouraged.

  9. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

    OpenAIRE

    Liu Chang-Qin; Yan Bing; Wang Li-Ying; Sun Su-Yun; Zhang Hui-Jie; Yang Shu-Yu; Zhang Wei; Li Xue-Jun

    2011-01-01

    Abstract Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians. Methods One hundred and...

  10. CORRELATION BETWEEN CAROTID INTIMA MEDIA THICKNESS AND NEWLY DIAGNOSED HYPERTENSIVE PATIENTS

    Directory of Open Access Journals (Sweden)

    Rupak

    2015-09-01

    Full Text Available BACKGROUND: Hypertension is one of the leading causes of the global burden of disease and carotid intima - media thickness (IMT increases with hypertension. Various studies have proved that IMT measurements correlated with pathologic measurements. So the study has been done to find the correlation between carotid intima media thickness and hypertension in newly diagnosed cases. METHODS: 52 newly diagnosed hypertensive subjects ( A ge>18yrs were taken along with matched controls. Known hypertensive cases and secondary hypertension cases were excluded from the study. cIMT measurement was taken in all patients. RESULTS: mean age of cases was 42.8years and BMI was 26.3kg/m 2 . For all of the subjects combined (n=104, cIMT correlated with office systolic blood pressure (SBP (r = 0.48; p<0.001 but no correlation was found between diastolic blood pressure and cIMT(r=0.15, p=0.11. Among hypertensive subjects (n=52, there was a significant positive correlation between cIMT and SBP (r=0.59, p<0.001 but no correlation was found between DBP and cIMT (r = 0.202; p = 0.15 in the hypertensive subjects. No correlation was found between BMI and smoking with cIMT. CONCLUSION: Increase in blood pressure correlates with increase in carotid intima media thickness, particularly with systolic blood pressure.

  11. Correlation Between the Intima-Media Thickness of the Proximal and Distal Common Carotids

    International Nuclear Information System (INIS)

    Increased IMT (intima-media thickness) in carotids is used as an early atherosclerosis marker and to evaluate the risk of cardiovascular problems. Ultrasound is used in the evaluation because it is accessible and low cost. Measurements for different carotid regions are described. To compare the proximal and distal region IMTs for the bilateral common carotid and guide its use in clinical practice. The IMT was measured in the proximal and distal common carotid arteries of 798 individuals (35-74 years old) of both genders using high-resolution ultrasound. Pearson's correlation coefficient was used to establish associations. The analyses were initially performed for the entire sample as well as subgroups with IMT <0.90 mm (49% of the sample) and ≥0.90 mm for at least one measurement site. The statistical significance was p < 0.05. The correlations investigated were significant. In the group with an IMT <0.90 mm, the correlations were between 0.44 and 0.62. In the subgroup with an IMT ≥0.90 mm, the correlations were significantly reduced to between 0.20 and 0.40. The data suggest that the IMT is more uniform along the carotid during early development and tends develop focally as it progresses. Therefore, in clinical evaluations of patients, the common carotid length should be investigated bilaterally to better use the available software and discern the IMT

  12. Independent Association of Muscular Strength and Carotid Intima-Media Thickness in Children.

    Science.gov (United States)

    Melo, X; Santa-Clara, H; Santos, D A; Pimenta, N M; Minderico, C S; Fernhall, B; Sardinha, L B

    2015-07-01

    The aim of this cross-sectional study was to examine the influence of muscular strength on carotid intima-media thickness (cIMT) in children, controlling for the effect of cardiorespiratory fitness (CRF) and central adiposity and to examine if differences among muscular strength tertiles translate to physiological differences. We assessed cIMT of the common carotid artery in 366 children between 11-12 years of age (191 girls). Measures included cIMT assessed with high-resolution ultrasonography, a maximal handgrip strength test, body fat mass and lean mass from DXA and CRF determined using a maximal cycle ergometer test. Association between muscular strength and cIMT adjusted for CRF and central adiposity, as measured by trunk fat, was tested with multiple linear regression analysis. Differences in risk factors among muscular strength groups were tested with ANOVA. The Muscular Strength Index (MSI) was inversely associated with cIMT independently of CRF and central adiposity (p<0.05). The low MSI group had the highest values of cIMT, waist circumference and systolic blood pressure and the lowest CRF (p<0.05). There was an inverse and independent association between muscular strength and cIMT. Low muscular strength was associated with higher levels of cardiovascular disease risk factors in children. PMID:25875317

  13. Carotid intima-media thickness as a marker of atherosclerosis in hemodialysis patients.

    Science.gov (United States)

    Abbasi, M R; Abbaszadeh, S H; Rokni-Yazdi, H; Lessan-Pezeshki, M; Khatami, M R; Mahdavi-Mazdeh, M; Ahmadi, F; Seifi, S; Gatmiri, S M

    2016-01-01

    Atherosclerotic changes in carotid arteries of hemodialysis (HD) patients reflect global atherosclerotic changes in vasculature. Carotid intima-media thickness (CIMT) can be used for atherosclerosis prediction and assessment of cardiovascular risks in HD patients, and thus screening high-risk patients. In this cross-sectional study, CIMT was measured using ultrasonography (B-mode with 5-10-MHz multifrequency linear probe) in HD patients in our hospitals. Additionally, we assessed the relationship between their CIMT and some cardiovascular risk factors. A total of 62 HD patients (64.5% male) were included. Age, body mass index, low-density lipoprotein, fasting blood sugar, history of diabetes mellitus and cardiovascular disease, serum albumin, and duration and adequacy of HD in study patients had significant association with their CIMT. There were no significant relationships between CIMT and patient's gender, smoking, serum calcium, phosphate, calcium x phosphate product, hemoglobin, and uric acid level. More diagnostic modalities must be performed for detecting the impact of atherosclerosis on HD patients with high CIMT. PMID:27051132

  14. Association of mitral annulus calcification, aortic valve calcification with carotid intima media thickness

    Directory of Open Access Journals (Sweden)

    Scuteri Angelo

    2004-10-01

    Full Text Available Abstract Background Mitral annular calcification (MAC and aortic annular calcification (AVC may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT, are also recognized as independent predictors of adverse cardiovascular outcomes. Aim To examine the relationship between the degree of calcification at mitral and/or aortic valve annulus and large artery structure (thickness. Methods We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP, pulse pressure (PP=SBP-DBP, body mass index (BMI, fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular/annular lesions independent scores based on acoustic densitometry: 1 = annular/valvular sclerosis/calcification absence; 2 = annular/valvular sclerosis; 3 = annular calcification; 4 = annular-valvular calcification; 5 = valvular calcification with no recognition of the leaflets. Results Patient score was the highest observed for either valvular/annulus. Mean cIMT increased linearly with increasing valvular calcification score, ranging from 3.9 ± 0.48 mm in controls to 12.9 ± 1.8 mm in those subjects scored 5 (p 0.0001. Conclusion MAC and AVC score can identify subgroups of patients with different cIMT values which indicate different incidence and prevalence of systemic artery diseases. This data may confirm MAC-AVC as a useful important diagnostic parameter of systemic atherosclerotic disease.

  15. Carotid intima-media thickness and distensibility measured by MRI at 3 T versus high-resolution ultrasound

    International Nuclear Information System (INIS)

    We evaluated an MRI protocol at 3 T for the assessment of morphological and functional properties of the common carotid artery (CCA) in 32 healthy volunteers and 20 patients with high-grade internal carotid artery stenosis. Wall thickness of the CCA was measured by using multislice 2D T2 dark blood fast spin echo sequences and compared with intima-media thickness (IMT) determined by ultrasound. Carotid distensibility coefficient (DC) quantified by blood pressure and CCA diameter change during the cardiac cycle was measured by ECG gated 3D T1 CINE MRI and M-mode ultrasound. Apart from generally higher values in MRI high agreement was found for wall thickness and compliance in volunteers and patients. Remaining differences between both methods may be attributed to slightly different methods for measuring IMT and DC. Our findings indicate that MRI at 3 T is a feasible and promising tool for the comprehensive assessment of normal carotid geometry and function. (orig.)

  16. [Carotid intima-media thickness; normal values from 4 years].

    Science.gov (United States)

    de Arriba Muñoz, Antonio; Domínguez Cajal, María Mercedes; Labarta Aizpún, José Ignacio; Domínguez Cunchillos, Manuel; Mayayo Dehesa, Esteban; Ferrández Longás, Ángel

    2013-01-01

    Introducción: El estudio de la arteria carotídea común mediante ultrasonidos, cada vez cobra mayor importancia para la prevención, tratamiento y evaluación del riesgo de desarrollar enfermedad cardiovascular. Un aumento del índice íntima-media se asocia con la presencia de otros factores cardiovasculares, enfermedad cardiovascular y cerebrovascular y ateroesclerosis en otras zonas del sistema vascular tanto en adultos como en población pediátrica. Material y métodos: Estudio transversal en 202 niños sanos de edades comprendidas entre 4 y 15 años en los que se han valorado parámetros auxológicos, tensión arterial sistólica y diastólica e índice íntima-media carotídea. Resultados: La muestra se compone de 100 varones y 102 mujeres, sin que existan diferencias entre ellos respecto al sexo; se presentan representaciones gráficas de los valores de índice íntima-media carotídea tanto en el total de la muestra como por sexos; existe una correlación positiva entre el índice íntima-media carotídeo con la edad (r = 0,229, p 0,01) y el IMC (r = 0,212, p media es un factor añadido para una identificación precoz de enfermedad cardiovascular y de su evolución tanto en población adulta como pediátrica.

  17. Carotid intima-media thickness correlation with lipid profile in patients with familial hypercholesterolemia versus controls

    International Nuclear Information System (INIS)

    To determine the variations in carotid intima-media thickness (CIMT) in familial hypercholesterolemia (FH) patients and its use as predictive marker for premature cardiovascular diseases. Familial hypercholesterolemia was clinically diagnosed by premature coronary diseases, xanthomas, arcus cornealis and family history of premature coronary heart diseases. Controls were age matched normal individuals without hypercholesterolemia. Their lipid profile was tested after overnight fasting. CIMT was measured in mm using B-mode ultrasonography using linear probe. Student t-test was applied to compare mean CIMT of cases and the control. The mean CIMT values of the FH cases were correlated with LDL using Pearson's correlation test. Forty cases with hypercholesterolemia gave consent to participate in the study. These patients had total cholesterol 200 mg/dL and LDL 160 mg/dL as compared to twenty controls of similar age with total cholesterol ? 200 mg/dL and LDL 130 mg/dL. Mean CIMT for the cases was 0.77 + 0.18 mm while mean CIMT for control was 0.59 + 0.08 mm. The mean CIMT for the cases ranged from 0.7-1.83 mm and 0.48-0.73 mm for controls. Among the FH cases, 25% (n=11) had arterial plaques. Mean CIMT was significantly correlated to LDL-cholesterol (r 0.725**, p < 0.001). In this study, CIMT was found to be significantly increased in familial hypercholesterolemia and it correlated with raised LDL-cholesterol. Both are predictive of premature cardiovascular diseases. (author)

  18. Progression Rates of Carotid Intima-media Thickness and Adventitial Diameter during the Menopausal Transition

    Science.gov (United States)

    El Khoudary, Samar R.; Wildman, Rachel P.; Matthews, Karen; Thurston, Rebecca C.; Bromberger, Joyce T.; Sutton-Tyrrell, Kim

    2012-01-01

    Objectives The authors assessed whether the levels and progression rates of carotid intima-media thickness (IMT) and adventitial diameter (AD) vary by menopausal stage. Methods 249 Women (42–57 years old, premenopausal (49%) or early peri-menopausal (46%)) from the Study of Women’s Health Across the Nation were included in the current analysis. Participants were followed for up to 9 years (median=3.7 years) and had up to 5 carotid scans. Linear mixed models were used for analysis. Results The overall rate of change in IMT was 0.007 mm/year. Independent of age and race, progression rate of IMT increased substantially in late peri-menopausal stage (0.017 mm/year) compared to both premenopausal (0.007 mm/year) and early peri-menopausal (0.005 mm/year) stages; (P≤0.05). For AD, while the overall rate of change was negative (−0.009 mm/year), significant positive increases in the rate of change were observed in late peri-menopausal (0.024 mm/year) and postmenopausal (0.018 mm/year) stages compared to premenopausal stage (−0.032 mm/year); (P<0.05). In final models, postmenopausal stage was independently associated with higher levels of IMT and AD (P<0.05) compared to premenopausal stage. Conclusions During the menopausal transition, the carotid artery undergoes an adaptation that is reflected in adverse changes in IMT and AD. These changes may impact the vulnerability of the vessel to disease in older women. PMID:22990755

  19. Validation of the Carotid Intima-Media Thickness Variability: Can Manual Segmentations Be Trusted as Ground Truth?

    Science.gov (United States)

    Meiburger, Kristen M; Molinari, Filippo; Wong, Justin; Aguilar, Luis; Gallo, Diego; Steinman, David A; Morbiducci, Umberto

    2016-07-01

    The common carotid artery intima-media thickness (IMT) is widely accepted and used as an indicator of atherosclerosis. Recent studies, however, have found that the irregularity of the IMT along the carotid artery wall has a stronger correlation with atherosclerosis than the IMT itself. We set out to validate IMT variability (IMTV), a parameter defined to assess IMT irregularities along the wall. In particular, we analyzed whether or not manual segmentations of the lumen-intima and media-adventitia can be considered reliable in calculation of the IMTV parameter. To do this, we used a total of 60 simulated ultrasound images with a priori IMT and IMTV values. The images, simulated using the Fast And Mechanistic Ultrasound Simulation software, presented five different morphologies, four nominal IMT values and three different levels of variability along the carotid artery wall (no variability, small variability and large variability). Three experts traced the lumen-intima (LI) and media-adventitia (MA) profiles, and two automated algorithms were employed to obtain the LI and MA profiles. One expert also re-traced the LI and MA profiles to test intra-reader variability. The average IMTV measurements of the profiles used to simulate the longitudinal B-mode images were 0.002 ± 0.002, 0.149 ± 0.035 and 0.286 ± 0.068 mm for the cases of no variability, small variability and large variability, respectively. The IMTV measurements of one of the automated algorithms were statistically similar (p > 0.05, Wilcoxon signed rank) when considering small and large variability, but non-significant when considering no variability (p analysis of the carotid artery intima-media thickness irregularity. PMID:27072077

  20. Validation of the Carotid Intima-Media Thickness Variability: Can Manual Segmentations Be Trusted as Ground Truth?

    Science.gov (United States)

    Meiburger, Kristen M; Molinari, Filippo; Wong, Justin; Aguilar, Luis; Gallo, Diego; Steinman, David A; Morbiducci, Umberto

    2016-07-01

    The common carotid artery intima-media thickness (IMT) is widely accepted and used as an indicator of atherosclerosis. Recent studies, however, have found that the irregularity of the IMT along the carotid artery wall has a stronger correlation with atherosclerosis than the IMT itself. We set out to validate IMT variability (IMTV), a parameter defined to assess IMT irregularities along the wall. In particular, we analyzed whether or not manual segmentations of the lumen-intima and media-adventitia can be considered reliable in calculation of the IMTV parameter. To do this, we used a total of 60 simulated ultrasound images with a priori IMT and IMTV values. The images, simulated using the Fast And Mechanistic Ultrasound Simulation software, presented five different morphologies, four nominal IMT values and three different levels of variability along the carotid artery wall (no variability, small variability and large variability). Three experts traced the lumen-intima (LI) and media-adventitia (MA) profiles, and two automated algorithms were employed to obtain the LI and MA profiles. One expert also re-traced the LI and MA profiles to test intra-reader variability. The average IMTV measurements of the profiles used to simulate the longitudinal B-mode images were 0.002 ± 0.002, 0.149 ± 0.035 and 0.286 ± 0.068 mm for the cases of no variability, small variability and large variability, respectively. The IMTV measurements of one of the automated algorithms were statistically similar (p > 0.05, Wilcoxon signed rank) when considering small and large variability, but non-significant when considering no variability (p truth. On the other hand, our automated algorithm was found to be more reliable, indicating how automated techniques could therefore foster analysis of the carotid artery intima-media thickness irregularity.

  1. Intima-media thickness evaluation by B-mode ultrasound: Correlation with blood pressure levels and cardiac structures

    Directory of Open Access Journals (Sweden)

    F.L. Plavnik

    2000-01-01

    Full Text Available The aim of this study was to analyze the thickness of the intima-media complex (IMC using a noninvasive method. The carotid and femoral common arteries were evaluated by noninvasive B-mode ultrasound in 63 normotensive and in 52 hypertensive subjects and the thickness of the IMC was tested for correlation with blood pressure, cardiac structures and several clinical and biological parameters. The IMC was thicker in hypertensive than in normotensive subjects (0.67 ± 0.13 and 0.62 ± 0.16 vs 0.54 ± 0.09 and 0.52 ± 0.11 mm, respectively, P<0.0001. In normotensive patients, the simple linear regression showed significant correlations between IMC and age, body mass index and 24-h systolic blood pressure for both the carotid and femoral arteries. In hypertensives the carotid IMC was correlated with age and 24-h systolic blood pressure while femoral IMC was correlated only with 24-h diastolic blood pressure. Forward stepwise regression showed that age, body mass index and 24-h systolic blood pressure influenced the carotid IMC relationship (r2 = 0.39 in normotensives. On the other hand, the femoral IMC relationship was influenced by 24-h systolic blood pressure and age (r2 = 0.40. In hypertensives, age and 24-h systolic blood pressure were the most important determinants of carotid IMC (r2 = 0.37, while femoral IMC was influenced only by 24-h diastolic blood pressure (r2 = 0.10. There was an association between carotid IMC and echocardiographic findings in normotensives, while in hypertensives only the left posterior wall and interventricular septum were associated with femoral IMC. We conclude that age and blood pressure influence the intima-media thickness, while echocardiographic changes are associated with the IMC.

  2. Intima-media thickness evaluation by B-mode ultrasound. Correlation with blood pressure levels and cardiac structures.

    Science.gov (United States)

    Plavnik, F L; Ajzen, S; Kohlmann, O; Tavares, A; Zanella, M T; Ribeiro, A B; Ramos, O L

    2000-01-01

    The aim of this study was to analyze the thickness of the intima-media complex (IMC) using a noninvasive method. The carotid and femoral common arteries were evaluated by noninvasive B-mode ultrasound in 63 normotensive and in 52 hypertensive subjects and the thickness of the IMC was tested for correlation with blood pressure, cardiac structures and several clinical and biological parameters. The IMC was thicker in hypertensive than in normotensive subjects (0.67 +/- 0.13 and 0.62 +/- 0.16 vs 0.54 +/- 0.09 and 0.52 +/- 0.11 mm, respectively, P<0.0001). In normotensive patients, the simple linear regression showed significant correlations between IMC and age, body mass index and 24-h systolic blood pressure for both the carotid and femoral arteries. In hypertensives the carotid IMC was correlated with age and 24-h systolic blood pressure while femoral IMC was correlated only with 24-h diastolic blood pressure. Forward stepwise regression showed that age, body mass index and 24-h systolic blood pressure influenced the carotid IMC relationship (r2 = 0.39) in normotensives. On the other hand, the femoral IMC relationship was influenced by 24-h systolic blood pressure and age (r2 = 0.40). In hypertensives, age and 24-h systolic blood pressure were the most important determinants of carotid IMC (r2 = 0.37), while femoral IMC was influenced only by 24-h diastolic blood pressure (r2 = 0.10). There was an association between carotid IMC and echocardiographic findings in normotensives, while in hypertensives only the left posterior wall and interventricular septum were associated with femoral IMC. We conclude that age and blood pressure influence the intima-media thickness, while echocardiographic changes are associated with the IMC. PMID:10625875

  3. Association of intima-media thickness of common carotid artery with the level of serum Adiponectin in type 2 diabetic patients%2型糖尿病患者颈动脉内膜中层厚度与血清脂联素的相关性

    Institute of Scientific and Technical Information of China (English)

    张艳红; 王宪; 高孝斗; 许华强; 王彬

    2009-01-01

    Objective To observe the Association of intima-media thickness of common carotid artery with the level of serum adiponectin in type 2 diabetic patients.Methods The intima-media thickness(IMT) of common carotid artery was measured using B-mode ultragonography in 65 patients with type 2 diabetes mellitus (DM) and 60 normal controls.The serum levels of adiponectin and biochemical index were measured respectively.In the tye 2 diabetes mellitus group,probable risk factors were analysed by multiple stepwise regression.Resuits Adiponeetin was risk of thickened IMT in type 2 DM.Conclusion The IMT is correlated with the level of adiponectin may be used as a reference index for the prediction of coronary artery disease.%目的 探讨2型糖尿病患者颈动脉内膜中层厚度(IMT)与血清脂联素(adiponectin)相关性.方法 对65例2型糖尿病患者和60例正常对照者,分别测定血清脂联素(adiponectin)及生化指标,采用超声测定IMT,比较两组间血清脂联素(adiponectin)及IMT水平.对2型糖尿病患者采用多元回归分析,统计颈动脉IMT和血清脂联素(adiponectin)之间的关系.结果 血清脂联素(adiponectin)与2型糖尿病患者颈动脉IMT增厚有关.结论 2型糖尿病患者颈动脉IMT与血清脂联素(adiponectin)呈正相关,提示2型糖尿病患者血清脂联素(adiponectin)可协助诊断冠心病.

  4. Relationship Between Carotid Intima-Media Thickness Using Ultrasonography and Diagnostic Indices of Metabolic Syndrome

    International Nuclear Information System (INIS)

    The aim of the present study was undertaken to investigate the association between diagnostic indices of metabolic syndrome(MetS) with carotid intima-media thickness using ultrasonography. The participants in the study were 315 male employees without carotid atherosclerosis and other cardiovascular disease. This study was approved by the Institutional Review Board of Occupational Safety and Health Research Institute. Written informed consent for the participants in this study was obtained from all individuals. Anthropometric parameters and biochemical characteristics were done using each specific equipment and the NCEP-ATP III criteria were used to define MetS. They were examined by B-mode ultrasound to measure the carotid intima-media thickness(carotid IMT) at the near and far walls of common carotid and bifurcation(bulb). The mean carotid IMT was 0.739±0.137 mm and it's thickness significantly increased with the increase in age. Also, amounts of systolic and diastolic blood pressure, triglyceride and fasting glucose were significantly increased with the increase in age. Carotid IMT were significantly correlated with BMI(r=0.170, p=0.004), systolic(r=0.148, p=0.011) and diastolic blood pressure(r=0.123, p=0.036) and HDL-cholesterol(r=-0.164, p=0.005). On multiple logistic regression analysis for the diagnostic indices of MetS, carotid IMT were significantly associated with blood pressure(OR=4.220, p<0.01) and MetS(OR=1.301, p<0.05). The results indicate that blood pressure and MetS are important risk factors for carotid atherosclerosis.

  5. Relationship Between Carotid Intima-Media Thickness Using Ultrasonography and Diagnostic Indices of Metabolic Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kyung Sun; Heo, Kyung Hwa; Won, Yong Lim; Kim, Ki Woong [Center for Occupational Disease Reserach, Occupational Safety and Health Research Insurance, KOSHA, Incheon (Korea, Republic of)

    2009-09-15

    The aim of the present study was undertaken to investigate the association between diagnostic indices of metabolic syndrome(MetS) with carotid intima-media thickness using ultrasonography. The participants in the study were 315 male employees without carotid atherosclerosis and other cardiovascular disease. This study was approved by the Institutional Review Board of Occupational Safety and Health Research Institute. Written informed consent for the participants in this study was obtained from all individuals. Anthropometric parameters and biochemical characteristics were done using each specific equipment and the NCEP-ATP III criteria were used to define MetS. They were examined by B-mode ultrasound to measure the carotid intima-media thickness(carotid IMT) at the near and far walls of common carotid and bifurcation(bulb). The mean carotid IMT was 0.739{+-}0.137 mm and it's thickness significantly increased with the increase in age. Also, amounts of systolic and diastolic blood pressure, triglyceride and fasting glucose were significantly increased with the increase in age. Carotid IMT were significantly correlated with BMI(r=0.170, p=0.004), systolic(r=0.148, p=0.011) and diastolic blood pressure(r=0.123, p=0.036) and HDL-cholesterol(r=-0.164, p=0.005). On multiple logistic regression analysis for the diagnostic indices of MetS, carotid IMT were significantly associated with blood pressure(OR=4.220, p<0.01) and MetS(OR=1.301, p<0.05). The results indicate that blood pressure and MetS are important risk factors for carotid atherosclerosis.

  6. Carotid intima media thickness is associated with plasma adiponectin but not with the leptin: adiponectin ratio independently of metabolic syndrome

    NARCIS (Netherlands)

    R.P.F. Dullaart; P.J.W.H. Kappelle; G.M. Dallinga-Thie

    2010-01-01

    Purpose: A recent report showed no benefit of the leptin: adiponectin ratio (L: A ratio) over individual adipokine levels in CHD prediction [ 8]. We determined associations of carotid intima media thickness (IMT) with the L: A ratio taking account of cardiovascular risk factors in a high risk popula

  7. Carotid intima media thickness is associated with plasma adiponectin but not with the leptin : adiponectin ratio independently of metabolic syndrome

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; Kappelle, Paul J. W. H.; Dallinga-Thie, Geesje M.

    2010-01-01

    Purpose: A recent report showed no benefit of the leptin: adiponectin ratio (L: A ratio) over individual adipokine levels in CHD prediction [ 8]. We determined associations of carotid intima media thickness (IMT) with the L: A ratio taking account of cardiovascular risk factors in a high risk popula

  8. Progression of Carotid Intima-Media Thickness as Predictor of Vascular Events Results from the IMPROVE Study

    NARCIS (Netherlands)

    Baldassarre, Damiano; Veglia, Fabrizio; Hamsten, Anders; Humphries, Steve E.; Rauramaa, Rainer; de Faire, Ulf; Smit, Andries J.; Giral, Philippe; Kurl, Sudhir; Mannarino, Elmo; Grossi, Enzo; Paoletti, Rodolfo; Tremoli, Elena

    2013-01-01

    Objective-To investigate whether several different measures of carotid intima-media thickness (IMT) progression are associated with subsequent vascular events and whether such associations are independent of baseline carotid atherosclerotic profile and Framingham risk factors. Approach and Results-A

  9. Carotid intima-media thickness in children with end-stage renal disease on dialysis.

    Science.gov (United States)

    Gheissari, A; Sirous, M; Hajzargarbashi, T; Kelishadi, R; Merrikhi, A; Azhir, A

    2010-01-01

    Cardiovascular morbidity and mortality are common in end stage renal disease (ESRD) patients. There is scarce data on carotid and bulb intima-media thickness (IMT-C and IMT-B) as an early marker of atherosclerosis and related factors in children on hemodialysis (HD) and peritoneal dialysis (PD). Since we did not have enough information about our patients, this study was carried on all ESRD children (hemodialysis and peritoneal dialysis) in a referral center. Data was collected from 16 ESRD children under 18 years with seven patients on PD and nine on HD. Lab tests and biochemical parameters including serum von Willebrand factor (vWF), homocystein, apo lipoprotein A, apo lipoprotein B and quantitative CRP were measured in fasting patients just before initiating dialysis. IMT-C and IMT-B were measured by gray scale ultrasound using 7.5 MHZ probe. The mean of age was 12.76+/-4.5 years. The mean duration of dialysis in HD and PD patients were not significantly different; 11.88+/-3.25 months and 10.14+/-2.4 months respectively. Mean of systolic blood pressure in HD group was significantly higher than PD group, 135.55+/-25.54 mmHg versus 121.42+/-12.14 mmHg, Phomocystein and IMT-C. However, we could not demonstrate any difference between IMT-B in case and control group. After adjusting for age, partial correlation showed significant correlation between IMT-C and following factors: N-PTH and serum alkaline phosphatase. Longitudinal studies with large size samples are needed to clarify the contributing factors with intima-media thickness in ESRD children. PMID:20535268

  10. Homocysteine and carotid intima-media thickness in ischemic stroke patients are not correlated

    Directory of Open Access Journals (Sweden)

    George Ntaios

    2008-04-01

    Full Text Available George Ntaios1, Christos Savopoulos1, Apostolos Hatzitolios1, Ippoliti Ekonomou2, Evangelos Destanis2, Ioannis Chryssogonidis2, Anastasia Chatzinikolaou3, Ifigenia Pidonia3, Dimitrios Karamitsos11First Propedeutic Department of Internal Medicine; 2Department of Radiology; 3Department of Biochemistry, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceIntroduction: Hyperhomocysteinemia has been linked to cardiovascular morbidity and mortality by numerous authors. Whether this association is causal or not remains uncertain. The aim of the study was to investigate the association of hyperhomocysteinemia with the degree of carotid atherosclerosis in stroke patients.Methods: We studied 97 Greek patients in our stroke unit who were hospitalized as a result of ischemic stroke between March 2006 and May 2007. The patients were divided into two groups: the first (52 patients included stroke patients with serum levels of homocysteine below 15 µmol/L, but in the second group (45 patients serum homocysteine exceeded this value. We measured carotid intima-media thickness (cIMT in all patients and correlated it with serum homocysteine.Results: The mean homocysteine concentration was 11.5 µmol/L in the first group and 21.5 µmol/L in the second group. Carotid IMT was 1.012 mm in the first group, and 1.015 mm in the second group, an insignificant difference. On the contrary, serum folate concentration was 21.3 nmol/L in the first group compared with 16.7 nmol/L in the second group (p < 0.001. VitB12 was 401 pmol/L in the first group and 340 pmol/L in the second group, a statistically significant difference (p < 0.001.Conclusions: Serum levels of homocysteine were not correlated with cIMT in ischemic stroke patients. Both folate and vitB12 were decreased in hyperhomocysteinemic ischemic stroke patients.Keywords: homocysteine, carotid intima-media thickness, ischemic stroke

  11. 2型糖尿病患者血清瘦素与颈动脉内膜中层厚度的相关性研究%Association of serum leptin with intima-media thickness of carotid artery in type 2 diabetes patients

    Institute of Scientific and Technical Information of China (English)

    刘振华; 毕会民; 贺艳菊; 张玉国

    2009-01-01

    Objective To investigate the relationship between serum leptin and carotid intima-media thickness in patients with type 2 diabetes mellitus. Methods 35 patients with type 2 diabetes mellitus (DM) and 16 normal controls were studied. Fasting serum leptin, fasting glucose(FBG), HbAlc, C-peptide, lipide, systolic(SBP), diastolic blood pressure(DBP), body mass index (BMI) and waist circ-umference (WC) were measured in all subjects. The intima-media thickness (IMT) of common carotid artery was measured by high-resolu-tion ultrasound imaging. Results IMT of T2DM was positively correlated with leptin concentration. Conclusion Serum leptin concentra-tion is independently associated with the IMT of carotid artery, which suggest that leptin may be an independent risk factor of atherosclerosis.%目的 探讨2型糖尿病(T2DM)患者血清瘦素水平与颈动脉内膜中层厚度(IMT)的关系.方法 选择35例2型糖尿痛患者、16例正常对照者,分别测定其血清瘦素、空腹血糖、糖化血红蛋白AIc(HbAlc)、C肽、血脂、血压、体重指数(BMI)及腰围,同时使用高分辨率超声检测双侧颈动脉IMT.结果 T2DM患者血清瘦素浓度与颈动脉IMT呈显著正相关.结论 血清瘦素浓度与颈动脉IMT的增厚有关,提示瘦素可能是导致T2DM患者动脉粥样硬化中的一项危险因素.

  12. Ultrasonic Measurement of Common Carotid Intima-Media Thickness in Type 2 Diabetic and Non-Diabetic Patients

    International Nuclear Information System (INIS)

    Diabetes mellitus is a widespread disease. Its vascular complications can be characterized by arteriosclerosis formation in carotid arteries. Due to its delayed diagnosis resulting in more complications in Iran, it seems that screening diabetic patients is mandatory. The aim of this study was to compare the intima-media thickness (IMT) of carotid artery in diabetic and non-diabetic patients. This is a cross-sectional study, which included 80 participants (40 diabetics and 40 non-diabetics). By using ultrasound, bilateral IMTs of the distal carotid were measured and the data were analyzed using ANOVA and multivariate regression tests in SPSS 14. The mean IMT was 0.97 in diabetic patients and 0.63 in non-diabetics (P < 0.001). Age and gender had significant positive effects on the increase of IMT (P < 0.05 and P < 0.005, respectively for age and gender). Past medical history of coronary heart disease (CHD) and cerebrovascular accident (CVA) in diabetes is associated significantly with an increase in IMT (P =0.019 and 0.027 respectively). Other confounding variables such as smoking, history of hypertension (HTN) and hyperlipoproteinemia (HLP) in diabetic patients showed no significant relationship with the increase of IMT. Although measuring the IMT of the carotid artery by sonography is a useful tool for screening diabetic patients, more studies are needed for determining how to use these measurements in promoting the patients outcomes

  13. Evaluation of the Beta Stiffness Index and Carotid Intima-Media Thickness in Asian Patients With Psoriasis.

    Science.gov (United States)

    Kim, Soo Young; Yang, Hyun Suk; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

    2015-10-01

    The risk of cardiovascular (CV) events is reportedly elevated in patients with psoriasis. Evaluation of the beta stiffness index (BSI) and carotid intima-media thickness (cIMT) are noninvasive methods of assessing arterial stiffness and subclinical atherosclerosis. We aimed to determine carotid arterial stiffness and cIMT, using high-resolution ultrasonography, in patients with psoriasis compared with controls, and to analyze whether psoriasis is an independent risk factor for atherosclerosis. A total of 54 consecutive patients with psoriasis and 60 age and gender-matched healthy controls were enrolled. Compared with control participants, patients with psoriasis exhibited a significantly higher BSI (P psoriasis but statistically not significant (P = .076). BSI was positively correlated with age, systolic blood pressure, disease severity defined according to history of systemic treatment, and traditional CV risk factors. Also, psoriasis was independently associated with BSI. These findings suggest that psoriasis is an independent risk factor for arterial stiffness, and the BSI is an earlier indicator of atherosclerosis than cIMT in these patients.

  14. Serum calcium level is related to both intima-media thickness and carotid atherosclerosis: a neglect risk factor in obese/overweight subjects

    Directory of Open Access Journals (Sweden)

    Montalcini Tiziana

    2012-06-01

    Full Text Available Abstract Background Experimental studies suggested that high serum calcium may be important in the pathogenesis of vascular diseases. Since calcium seems to affect specifically the cerebrovascular district, aim of this study was to determine the relation between serum calcium levels, within normal range, and subclinical atherosclerosis in the carotid arteries, in a population of obese/overweight subjects. Methods In our retrospective study we included 472 subjects (59% female with body mass index equal to or more than 25 kg/m2. They underwent a physical examination, a biochemical assessment (including calcium evaluation and a B-mode ultrasonography of the extracranial carotid arteries to detect carotid atherosclerosis presence and to measure intima-media thickness. Results Mean age of the population was 50 ±12 years. Prevalence of the Carotid atherosclerosis was 40%. Mean carotid intima-media thickness was 0,66 ± 0,18 mm. The univariate and multivariate analysis showed an association between calcium and carotid intima-media thickness (p = 0,035. We divided the population in serum calcium tertiles. We found an higher carotid atherosclerosis prevalence in the III tertile in comparison to that of the I tertile (p = 0,039. Conclusions In this study we found a positive relation between serum calcium levels, within normal range, and subclinical atherosclerosis in the carotid arteries, in a population of obese/overweight subjects. It is important to consider the impact of the serum calcium levels in the overall risk assessment of patients, at least in obese subjects.

  15. ECG-based frame selection and curvature-based ROI detection for measuring carotid intima-media thickness

    Science.gov (United States)

    Sharma, Haripriya; Golla, Ramsri G.; Zhang, Yu; Kendall, Christopher B.; Hurst, R. Todd; Tajbakhsh, Nima; Liang, Jianming

    2014-03-01

    Carotid intima-media thickness (CIMT) has proven to be sensitive for predicting individual risk of cardiovascular diseases (CVD). The CIMT is measured based on region of interest (ROIs) in end-diastolic ultrasound frames (EUFs). To interpret CIMT videos, in the current practice, the EUFs and ROIs must be manually selected, a process that is tedious and time consuming. To reduce CIMT interpretation time, this paper presents a novel method for automatically selecting EUFs and determining ROIs in ultrasound videos. The EUFs are selected based on the QRS complex of the electrocardiogram (ECG) signal associated with the ultrasound video, and the ROI is detected based on image intensity and curvature of the carotid artery bulb. Once a EUF is selected and its corresponding ROI is determined, our system measures CIMT using the snake algorithm extended with hard constraints [1,6-7] by computing the average thickness and maximum thickness, calculating the vascular age, and generating a patient's report. In this study, we utilize 23 subjects. Each subject has 4 videos, and 3 EUFs are selected in each video, resulting in a total of 272 ROIs. By comparing with the reference provided by an expert for both frame selection and ROI detection, we achieve 92.96% sensitivity and 97.62% specificity for EUF selection, and 81.25% accuracy in ROI detection.

  16. Correlation between Common Carotid Artery Intima-media Thickness and Degree of Retinopathy in Type 2 Diabetes Mellitus%2型糖尿病视网膜病变程度与颈总动脉内-中膜厚度的相关性研究

    Institute of Scientific and Technical Information of China (English)

    李晶晶; 邓又斌; 杨顺实

    2011-01-01

    目的 评估2型糖尿病患者(diabetes mellitus,DM)视网膜病变程度与颈总动脉内-中膜厚度(common carotid artery inti-ma-media thickness,CCA IMT)的相关性,以期早期发现糖尿病视网膜病变(diabetic retinopathy,DR)并评估其病变程度.方法 筛选2型糖尿病患者84例.根据眼底荧光造影的结果分为糖尿病无视网膜病变(non-diabetic retinopathy,NDR)组、非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)组及增殖期糖尿病视网膜病变(proliferative di-abetic retinopathy,PDR)组三组.记录各组病例的性别、年龄、糖尿病病程,测量其CCA IMT、空腹血糖(fasting blood glu-cose,FBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、血清甘油三脂(serum triglycerides,TG)、总胆固醇(totalcholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholestero,LDL-C)及高密度脂蛋白胆固醇(high-density lipo-protein cholesterol,HDL-C).结果 CCA IMT、FBG、HbA1c及糖尿病病程均同DR的程度具有正相关性(P<0.05);且排除了FBG、HbA1c及糖尿病病程的影响后,CCA IMT仍与DR程度相关(P<0.01).结论 2型糖尿病患者DR的程度同CCA IMT具有正相关性.%Objective To estimate the correlation between the degree of the diabetic retinopathy(DR)and the common carotid artery intima-media thickness (CCA IMT)in type 2 diabetes mellitus(DM)for early detection of DR and the the extent of their lesions. Methods A total of 84 patients with type 2 diabetes mellitus,according to the result of fundus fluorescein angiography,were divided into three groups:non-diabetic retinopathy(NDR)group,non-proliferative diabetic retinopathy(NPDR)group and proliferative diabetic retinopathy(PDR)group. In each group, gender, age and duration of diabetes were recorded, and common carotid artery intima-media thickness(CCA IMT), fasting blood glucose (FBG) ,glycosylated hemoglobin( HbAlc), serum triglycerides(TG), total cholesterol(TC), low

  17. Association between fasting and postprandial triglyceride levels and carotid intima-media thickness in type 2 diabetes patients

    Institute of Scientific and Technical Information of China (English)

    陈香; 田浩明; 刘瑞

    2003-01-01

    Objective To investigate the association of fasting and postpiandial triglyceride with carotid intima-media thickness among type 2 diabetic patients in southeast China.Methods A total of 78 type 2 diabetic patients from southeast China were recruited. All the subjects underwent a standardized mixed-meal test (SMMT) and an oral glucose tolerance test. Carotid intima-media thickness (IMT) was measured by color doppler ultrasound examination.Results Postprandial triglyceride (PTG) after SMMT increased significantly in type 2 diabetic patients. The carotid IMT in patients with postprandial hypertriglyceridemia was sinificantly greater than that in patients with postprandial normal-triglyceridemia (0.90 mm vs 0.81 mm, P0.05).Conclusion The results suggest that postprandial hypertriglyeridemia may be an independent risk factor of early atherosclerosis in type 2 diabetes.

  18. Impact of carotid intima-media thickness on long-term outcome in hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Munna Lal Patel

    2015-01-01

    Full Text Available Background: Chronic kidney disease (CKD patients on hemodialysis are highly prone to cardiovascular disease, which accounts for roughly half of the mortality in these patients. Atherosclerosis begins many years before the development of clinical manifestations. Measurement of carotid intima-media thickness (CIMT is a noninvasive procedure to detect early atherosclerotic changes. Aims: The aim of the study was to evaluate the correlation between CIMT and cardiovascular risk factors and to investigate its prognostic significance in CKD patients on hemodialysis. Materials and Methods: This was a prospective study carried out over a period of 18 months. Total 88 patients on hemodialysis and 50 healthy controls were enrolled in the study. Biochemical assay and CIMT was assessed using the high resolution 7.5 MHz sonography technique in all subjects. Results: Significant positive correlation was found with age, blood urea, serum creatinine, serum triglyceride, low-density lipoprotein, serum phosphorus, serum calcium-phosphorus product, serum uric acid, 24 h urine protein, systolic blood pressure, diastolic blood pressure, and body mass index. Negative correlation was found with estimated glomerular filtration rate. Adjusted hazards ratios of all cause and cardiovascular mortality for an increase of 0.1 mm in CIMT was 1.16 (95% confidence interval 0.15-9.09. Patients with CIMT value 0.97 mm had a renal survival rate of 16.5%. Conclusion: Uremia is an additive risk factors in those subjects who have raised CIMT despite of traditional cardiovascular risk factors.

  19. Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients

    Directory of Open Access Journals (Sweden)

    Miklós Káplár

    2016-01-01

    Full Text Available Introduction. Mannose-binding lectin (MBL activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM patients. Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls. Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001. In T2DM, the lowest cIMT was seen in patients with normal MBL level (500–1000 while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002. According to multiple regression analysis the main predictors of IMT in T2DM are age (P<0.003, ApoA level (P=0.023, and the MBL (P=0.036. Conclusions. Our results suggest a dual role of MBL as a risk factor for cIMT in T2DM. MBL may also be used as a marker of macrovascular disease, as both low and high levels indicate the susceptibility for atherosclerosis in T2DM.

  20. Ghrelin Does not Alter Aortic Intima-Media Thickness and Adipose Tissue Characteristics in Control and Obese Mice

    OpenAIRE

    Zoya Tahergorabi; Bahman Rashidi; Majid Khazaei

    2013-01-01

    Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. Materials and Methods: This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), con...

  1. Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

    OpenAIRE

    Paramo, J. A.; Orbe, J.; Beloqui, O. (Óscar); Benito, A.; Colina, I. (Inmaculada); Martinez-Vila, E; Diez, J.

    2004-01-01

    BACKGROUND AND PURPOSE: Thrombin, a central enzyme in the clotting cascade, plays a role not only in thrombosis but also in the progression of atherosclerosis. We studied the relationship between prothrombin fragment 1+2 (F1+2), a specific marker of thrombin generation in vivo, and carotid intima-media thickness (IMT), an index of subclinical atherosclerosis. METHODS: We examined 181 asymptomatic middle-aged subjects (mean age 55.6 years, 76.7% men) free of overt clinical atherosclerotic ...

  2. Completeness of carotid intima media thickness measurements depends on body composition: the RADIANCE 1 and 2 trials.

    OpenAIRE

    Dogan, S; Duivenvoorden, R.; Grobbee, D E; Kastelein, J. J.; Shear, C.L.; Evans, G W; Visseren, F.L.; Bots, M. L.; Stalenhoef, A F H

    2010-01-01

    AIM: Ultrasound protocols to measure carotid intima media thickness (CIMT) differ considerably with regard to the inclusion of the number of carotid segments and angles used. Detailed information on the completeness of CIMT information is often lacking in published reports, and at most, overall percentages are presented. We therefore decided to study the completeness of CIMT measurements and its relation with vascular risk factors using data from two CIMT intervention studies: one among famil...

  3. Carotid intima-media thickness and apolipoproteins in patients of ischemic stroke in a rural hospital setting in central India: A cross-sectional study

    OpenAIRE

    Jyoti Jain; Tejal Lathia; Om Prakash Gupta; Vishakha Jain

    2012-01-01

    Context: Carotid intima-media thickness (CIMT) and apolipoproteins have been found as a risk factor for ischemic stroke . Objective: The objective was to study the carotid intima-media thickness, apolipoproteins, and their relation in patients of ischemic stroke in central rural India. Settings and Design: A cross-sectional study was performed in a rural hospital in central India. Materials and Methods: In all patients of ischemic stroke proven by computerized tomography (CT), CIMT, apolipopr...

  4. Inverse association of serum vitamin D in relation to carotid intima-media thickness in Chinese postmenopausal women.

    Directory of Open Access Journals (Sweden)

    Yaping Hao

    Full Text Available This study aimed to investigate the relationship between serum vitamin D level and carotid intima-media thickness (C-IMT in Chinese postmenopausal women.Nine hundred and twenty six Chinese postmenopausal women without carotid artery plaque or history of cardiovascular disease were selected for analysis. Measurements of serum 25 hydroxyvitamin D3 (25(OHD3 concentration and C-IMT were made by electrochemiluminescence immunoassay and B-mode ultrasound, respectively. Trend analysis was conducted according to tertiles of C-IMT.The median serum 25(OHD3 level was 11.03 ng/mL, with an interquartile range of 8.22-14.70. A decreasing trend of serum 25(OHD3 level was accompanied by increased C-IMT tertiles (P for trend = 0.001. Correlation analysis found an inverse relationship between serum 25(OHD3 level and C-IMT (r = -0.113, P = 0.001. After adjustment for confounding factors, multiple regression analysis showed that serum 25(OHD3 level independently and negatively associated with C-IMT (Standard β = -0.112, P < 0.001. Moreover, the inverse correlation of serum 25(OHD3 with C-IMT was also found in a subgroup of women with normal glucose tolerance, blood pressure and body mass index, and without undergoing lipid-lowering therapy (standard β = -0.140, P = 0.018.Serum 25(OHD3 level was inversely correlated with C-IMT in Chinese postmenopausal women.

  5. Associations of cardiovascular risk factors, carotid intima-media thickness and manifest atherosclerotic vascular disease with carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Liira Helena

    2011-04-01

    Full Text Available Abstract Background The role of atherosclerosis in carpal tunnel syndrome (CTS has not previously been addressed in population studies. The aim of this study was to investigate the associations of cardiovascular risk factors, carotid artery intima-media thickness (IMT, and clinical atherosclerotic diseases with CTS. Methods In this cross sectional study, the target population consisted of subjects aged 30 or over who had participated in the national Finnish Health Survey in 2000-2001. Of the 7977 eligible subjects, 6254 (78.4% were included in our study. Carotid IMT was measured in a sub-sample of subjects aged 45 to 74 (N = 1353. Results Obesity (adjusted odds ratio (OR 2.4, 95% confidence interval (CI 1.1-5.4, high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. 200 vs. Conclusions Our findings suggest an association between CTS and cardiovascular risk factors in young people, and carotid IMT and clinical atherosclerotic vascular disease in older people. CTS may either be a manifestation of atherosclerosis, or both conditions may share similar risk factors.

  6. Continuous assessment of carotid intima-media thickness applied to estimate a volumetric compliance using B-mode ultrasound sequences

    International Nuclear Information System (INIS)

    Recent reports have shown that the carotid artery wall had significant movements not only in the radial but also in the longitudinal direction during the cardiac cycle. Accordingly, the idea that longitudinal elongations could be systematically neglected for compliance estimations became controversial. Assuming a dynamic change in vessel length, the standard measurement of cross-sectional compliance can be revised. In this work, we propose to estimate a volumetric compliance based on continuous measurements of carotid diameter and intima-media thickness (IMT) from B-mode ultrasound sequences. Assuming the principle of conservation of the mass of wall volume (compressibility equals zero), a temporal longitudinal elongation can be calculated to estimate a volumetric compliance. Moreover, elongations can also be estimated allowing small compressibility factors to model some wall leakage. The cross-sectional and the volumetric compliance were estimated in 45 healthy volunteers and 19 asymptomatic patients. The standard measurement underestimated the volumetric compliance by 25% for young volunteers (p < 0.01) and 17% for patients (p < 0.05). When compressibility factors different from zero were allowed, volunteers and patients reached values of 9% and 4%, respectively. We conclude that a simultaneous assessment of carotid diameter and IMT can be employed to estimate a volumetric compliance incorporating a longitudinal elongation. The cross-sectional compliance, that neglects the change in vessel length, underestimates the volumetric compliance. (paper)

  7. Change in Elasticity Caused by Flow-Mediated Dilation Measured Only for Intima-Media Region of Brachial Artery

    Science.gov (United States)

    Sugimoto, Masataka; Hasegawa, Hideyuki; Kanai, Hiroshi

    2005-08-01

    Endothelial dysfunction is considered to be an initial step of arteriosclerosis [R. Ross: N. Engl. J. Med. 340 (2004) 115]. For the assessment of the endothelium function, brachial artery flow-mediated dilation (FMD) caused by increased blood flow has been evaluated with ultrasonic diagnostic equipment. In the case of conventional methods, the change in artery diameter caused by FMD is measured [M. Hashimoto et al.: Circulation 92 (1995) 3431]. Although the arterial wall has a layered structure (intima, media, and adventitia), such a structure is not taken into account in conventional methods because the change in diameter depends on the characteristic of the entire wall. However, smooth muscle present only in the media contributes to FMD, whereas the collagen-rich hard adventitia does not contribute. In this study, we measure the change in elasticity of only the intima-media region including smooth muscle using the phased tracking method [H. Kanai et al.: IEEE Trans. Ultrason. Ferroelectr. Freq. Control 43 (1996) 791]. From the change in elasticity, FMD measured only for the intima-media region by our proposed method was found to be more sensitive than that measured for the entire wall by the conventional method.

  8. Bariatric surgery decreases carotid intima-media thickness in obese subjects

    Directory of Open Access Journals (Sweden)

    Gonzalo García

    2013-08-01

    Full Text Available Background: Obesity has long been associated with an increased risk of cardiovascular disease (CVD. The aim of this study was to evaluate the impact of substantial weight loss induced by bariatric surgery on carotid intima media thickness (C-IMT (surrogate marker of early atherosclerosis and classic factors of cardiovascular risk (CVRFs. Methods: thirty-one obesity patients were evaluated for bariatric surgery. Twenty-seven were undergone surgery, 14 Roux-en-Y gastric bypass surgery (GBS and 13 sleeve gastrectomy. The four obese patients who did not undergo surgery, were performed the same evaluations. Measurements: Body weight, BMI, blood pressure, total cholesterol, TC levels, LDL-C, HDL-C, TG, fasting plasma glucose and insulin, HOMA IR, and US B-mode C-IMT was measured. Results: After 354 ± 92 days follow up, 27 patients that underwent bariatric surgery evidenced a mean body mass index decrease from 38 to 27 k/m² (p < 0.001, simultaneously was observed improvement in CVRFs, 10 years Framingham risk and a significant reduction of therapeutic requirements. C-IMT diminished from a mean of 0.58 ± 0.14 mm to 0.49 ± 0.09 mm (p = 0.0001. Four patients that did not undergo surgery increased C-IMT from 0.52 ± 0.12 to 0.58 ± 0.13 mm (p = 0.03 with no significant changes in CVRFs. Conclusion: Weight loss, one year after bariatric surgery, GBS and sleeve gastrectomy, decreases C-IMT; improve CVRFs and 10 years Framingham risk.

  9. Carotis Intima Media Thickness in Female Patiens with Subclinical Hypothyroidism - Orijinal Article

    Directory of Open Access Journals (Sweden)

    Hayriye

    2010-12-01

    Full Text Available Objective: Recent studies have shown that subclinical hypothyroidism (SCH has similar cardiovascular risks with clinical hypothyroidism (CH. We evaluated carotis intima media thickness (CIMT-indicator of early changes in atherosclerotic process- in female patients, who have either CH or SCH, with similar age and demographic features. Materials and Methods: In this study, we included 81 female patients admitted to internal medicine and endocrinology outpatient clinic, diagnosed with CH (30 or SCH (51 according to their laboratory findings and who have not previously received treatment and 38 healthy women. BMI (body mass index, sistolic and diastolic blood pressure, triglycerides (TG, total cholesterol (TC, LDL cholesterol (LDL-C, HDL cholesterol (HDL-C, vitamin B-12, folate, homocysteine, high-sensitive C-reactive protein (Hs CRP, and CIMT were measured in all participants Results: There was not a statistical difference between the groups in TG, TC, HDL-C, LDL-C, vitamin B-12, and folate levels (p>0.05. On the other hand, SCH and CH groups differed statistically significantly from the control group for Hs CRP (p=0.011, homocysteine (p<0.001, and CIMT values. Additionally, age was found to be the most important factor for increase in CIMT when multiple linear regression analysis was performed.Conclusions: Lack of difference between CH patients and SCH patients in respect to Hs CRP, homocystein, and CIMT shows that inflammation and increase in CIMT starts during SCH period. Hence, we think that the increase in CIMT in SCH patients when TSH levels are higher than the normal range is a clinically important sign of early cardiovascular diseases. Turk Jem 2010; 14: 89-94

  10. Relationship between blood glucose and carotid intima media thickness: A meta-analysis

    Directory of Open Access Journals (Sweden)

    Einarson Thomas R

    2010-08-01

    Full Text Available Abstract Background Increased coronary intima media thickness (CIMT has been associated with adverse cardiovascular outcomes, as have increased glucose levels. The link has not been established between glucose and CIMT; therefore, we sought to assess the relationship between glucose and CIMT. Methods Medline, EMBASE, Scopus, and Cochrane databases were searched from inception through 2009 for original research reporting both postprandial glucose levels and CIMT measurements. Glucose was classified as normal, impaired, or diabetic. Outputs included inverse variance weighted effect size and also average correlation (using the Wang and Bushman approach. Data were combined using a random effects meta-analytic model. Heterogeneity as assessed using χ2 and I2; bias was examined using Egger plots and Begg-Mazumdar tau. Polynomial functions (i.e., linear, quadratic, cubic, quartic were fit to the data and the Akaike Information Criteria were used to select the optimal model. Results We identified 172 papers; 161 were rejected (19 inappropriate design, 8 had selected patients, 101 inappropriate outcomes leaving 11 accepted. We used data from 15,592 patients (8250 normals, 3013 impaired glucose, 4329 diabetics. There was no evidence of heterogeneity or publication bias. The overall correlation was 0.082 (CI95%:0.066-0.098; the overall effect size was 0.294 (0.245-0.343 between diabetics and normals and 0.137 (0.072-0.202 between normals and those with impaired glucose. The equation of best fit was linear (CIMT = 0.828 + 0.009*glucose. Conclusions There is a small but significant relationship between postprandial glucose levels and CIMT, which have both been associated with adverse cardiovascular outcomes.

  11. Arsenic Exposure From Drinking Water, Arsenic Methylation Capacity, and Carotid Intima-Media Thickness in Bangladesh

    Science.gov (United States)

    Chen, Yu; Wu, Fen; Graziano, Joseph H.; Parvez, Faruque; Liu, Mengling; Paul, Rina Rani; Shaheen, Ishrat; Sarwar, Golam; Ahmed, Alauddin; Islam, Tariqul; Slavkovich, Vesna; Rundek, Tatjana; Demmer, Ryan T.; Desvarieux, Moise; Ahsan, Habibul

    2013-01-01

    We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measured cIMT levels on average 7.2 years after baseline during 2010–2011. Arsenic exposure was measured in well water at baseline and in urine samples collected at baseline and during follow-up. Every 1-standard-deviation increase in urinary arsenic (357.9 µg/g creatinine) and well-water arsenic (102.0 µg/L) concentration was related to a 11.7-µm (95% confidence interval (CI): 1.8, 21.6) and 5.1-µm (95% CI: −0.2, 10.3) increase in cIMT, respectively. For every 10% increase in monomethylarsonic acid (MMA) percentage, there was an increase of 12.1 µm (95% CI: 0.4, 23.8) in cIMT. Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger. The findings indicate an effect of past long-term arsenic exposure on cIMT, which may be potentiated by suboptimal or incomplete arsenic methylation capacity. Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes. PMID:23788675

  12. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

    Directory of Open Access Journals (Sweden)

    Liu Chang-Qin

    2011-09-01

    Full Text Available Abstract Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT, as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians. Methods One hundred and seventy-one Chinese male vegetarians were screened for metabolic profile, cardiovascular risk and carotid IMT. They were compared with 129 age-matched omnivores recruited from a community-based health project. The effects of confounding factors were adjusted by stepwise logistic regression analysis. Results Compared to the omnivores, the vegetarians had lower BMI, weight, systolic blood pressure and diastolic blood pressure. Also, the levels of triglyceride, total cholesterol, HDL-Cholesterol, LDL-Cholesterol, ApoA1, ApoB, uric acid, albumin and γ-glutamyltransferase were significantly reduced in vegetarians. Omnivores had significantly higher fasting blood glucose than that of vegetarians. However, there were no differences in fasting insulin, C-reactive protein and HOMA-IR between the two groups. IMT was thinner in the vegetarian group than in the omnivore group (0.59 ± 0.16 vs. 0.63 ± 0.10 cm, P 11 years, those in tertile 1 ( Conclusion A decrease in multiple cardiovascular risk factors such as BMI, blood pressure and lipid profile was associated with vegetarian diet. Moreover, taking a low-calorie, low-protein, or vegetarian diet might have great beneficial effects on IMT through improved lipid profile, and the beneficial effects appeared to be correlated with the duration of vegetarian diet.

  13. Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh.

    Science.gov (United States)

    Chen, Yu; Wu, Fen; Graziano, Joseph H; Parvez, Faruque; Liu, Mengling; Paul, Rina Rani; Shaheen, Ishrat; Sarwar, Golam; Ahmed, Alauddin; Islam, Tariqul; Slavkovich, Vesna; Rundek, Tatjana; Demmer, Ryan T; Desvarieux, Moise; Ahsan, Habibul

    2013-08-01

    We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measured cIMT levels on average 7.2 years after baseline during 2010-2011. Arsenic exposure was measured in well water at baseline and in urine samples collected at baseline and during follow-up. Every 1-standard-deviation increase in urinary arsenic (357.9 µg/g creatinine) and well-water arsenic (102.0 µg/L) concentration was related to a 11.7-µm (95% confidence interval (CI): 1.8, 21.6) and 5.1-µm (95% CI: -0.2, 10.3) increase in cIMT, respectively. For every 10% increase in monomethylarsonic acid (MMA) percentage, there was an increase of 12.1 µm (95% CI: 0.4, 23.8) in cIMT. Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger. The findings indicate an effect of past long-term arsenic exposure on cIMT, which may be potentiated by suboptimal or incomplete arsenic methylation capacity. Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes.

  14. Association between microalbuminuria and subclinical atherosclerosis evaluated by carotid artery intima-media in elderly patients with normal renal function

    Directory of Open Access Journals (Sweden)

    Kong XiangLei

    2012-06-01

    Full Text Available Abstract Background Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, little is known about the direct association between subclinical atherosclerosis evaluated by carotid artery intima-media thickness (IMT and microalbuminuria in elderly patients with normal renal function. Methods Subjects were 272 elderly patients (age  ≥ 60 years with normoalbuminuria (n = 238 and microalbuminuria (n = 34. Carotid IMT was measured by means of high-resolution B-mode ultrasonography. Estimated glomerular filtration rate (eGFR ≥ 60 ml/min/1.73 m2 was defined as normal renal function. Those who had macroalbuminuria and atherosclerotic vascular disease were not included. Results Compared to subjects with normoalbuminuria, subjects with microalbuminuria had higher mean carotid IMT (1.02 ± 0.38 vs. 0.85 ± 0.28 mm; P  Conclusions A slight elevation of albuminuria is a significant determinant of carotid IMT independent of traditional cardiovascular risk factors in our patients. Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis when microalbuminuria is found in elderly patients, although with normal renal function.

  15. Impact of Cardiovascular Risk Factors on Carotid Intima-Media Thickness and Degree of Severity: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Lijie Ren

    Full Text Available Age, hypertension, dyslipidemia and diabetes are common cardiovascular risk factors (CVRFs that contribute to the development of atherosclerosis in cardiovascular system including carotid artery disease. However, the impact of these risk factors on the increased carotid intima-media thickness (cIMT and degree of carotid severity remains to be further clarified. This study aims to evaluate the relationship between CVRFs and degree of carotid severity and cIMT in high-risk subjects.Four thousand and three hundred ninety-four subjects with one or more risk factors were retrospectively reviewed in this study. Patients were divided into different groups based on age, the type and quantity of CVRFs. cIMT and degree of carotid artery stenosis were measured and analyzed based on carotid ultrasound imaging with findings compared to the CVRFs to determine the correlation between these variables.Aging was significantly associated with degree of severity (P < 0.05 and cIMT was significantly increased with age (P < 0.05. Individual CVRF analysis shows that hypertension was more related to the degree of severity than dyslipidemia and diabetes with corresponding abnormal cIMT rates being 79.39%, 72.98% and 32.37%, respectively. The prevalence of carotid atherosclerosis were 20.06%, 22.88% and 28.63%, respectively corresponding to patients with zero, one and more than one chronic diseases. The percentage of abnormal cIMT in hypertensive patient group with dyslipidemia is significantly higher than the other groups (P< 0.05.This study shows a direct correlation between the degree of carotid severity and cIMT and cardiovascular risk factors, especially with age and hypertension. Carotid atherosclerosis is closely related to the number of cardiovascular risk factors.

  16. Soya isoflavone consumption in relation to carotid intima-media thickness in Chinese equol excretors aged 40-65 years.

    Science.gov (United States)

    Cai, Yun; Guo, Kaiping; Chen, Chaogang; Wang, Ping; Zhang, Bo; Zhou, Quan; Mei, Fang; Su, Yixiang

    2012-11-14

    Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and carotid artery intima-media thickness (IMT) between equol excretors and non-excretors, and to evaluate the effect of soya isoflavone intakes on serum lipids and IMT in either equol excretors or non-excretors. Subjects (n 572; women n 362, men n 210) were recruited for the present study. An overnight urine sample was provided by each subject on their usual diet to quantify urinary concentrations of daidzein and equol. Far-wall IMT was determined by B-mode ultrasound in the right carotid at two sites, carotid bulb (CB-IMT) and common carotid artery (CCA-IMT), and fasting serum lipids were measured. Habitual dietary intakes were estimated with a FFQ, and soya isoflavone intake derived from the FFQ was assessed. Of the 572 subjects, the proportion of equol excretors on their usual diet was 25·0 % (n 143). Compared with non-excretors, equol excretors showed significantly lower serum TAG (-38·2 (95 % CI -70·4, -5·9) %, P = 0·012) and CCA-IMT (-4·9 (95 % CI -9·7, -0·3) %, P = 0·033). Equol excretors with higher daily isoflavone intakes (-5·4 mg/d) had significantly lower IMT (-16·2 %, P = 0·035) and tended to have higher HDL-cholesterol (P = 0·055) than did those with lower daily isoflavone intakes (1·5 mg/d), while no association was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors. In conclusion, the benefits of soya isoflavones in preventing CVD may be apparent among equol excretors only.

  17. Cerebrovascular Reactivity, Intima-Media Thickness, and Nephropathy Presence in Patients With Type 1 Diabetes

    OpenAIRE

    Kozera, Grzegorz M.; Wolnik, Bogumił; Kunicka, Katarzyna B.; Szczyrba, Sebastian; Wojczal, Joanna; Schminke, Ulf; Nyka, Walenty M.; Bieniaszewski, Leszek

    2009-01-01

    OBJECTIVE Cerebrovascular reactivity impairment was reported as a marker of cerebral microangiopathy in long-term type 1 diabetes. Intima-media complex thickening reflects early stages of macroangiopathy in type 1 diabetes. The analysis of the relationship between these variables and other microangiopathic complications might serve as a beneficial indicator for early prophylaxis in these patients. RESEARCH DESIGN AND METHODS Vasomotor reactivity reserve (VMRr) and breath-holding index (BHI) o...

  18. Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with inflammatory markers. One hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery (CCA). Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein (hs-CRP) were assessed. The IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients (38/105, 36.2%). Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5 years and 42.5 months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy. Radiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ≥50 years at 40 months post-radiotherapy

  19. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh.

    Science.gov (United States)

    Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G; Liu, Mengling; Cheng, Xin; Parvez, Faruque; Paul-Brutus, Rachelle; Paul, Rina Rani; Sarwar, Golam; Ahmed, Alauddin; Jiang, Jieying; Islam, Tariqul; Slavkovich, Vesna; Rundek, Tatjana; Demmer, Ryan T; Desvarieux, Moise; Ahsan, Habibul; Chen, Yu

    2014-05-01

    Epidemiologic studies that evaluated genetic susceptibility for the effects of arsenic exposure from drinking water on subclinical atherosclerosis are limited. We conducted a cross-sectional study of 1078 participants randomly selected from the Health Effects of Arsenic Longitudinal Study in Bangladesh to evaluate whether the association between arsenic exposure and carotid artery intima-media thickness (cIMT) differs by 207 single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction. Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT. For instance, the joint presence of a higher level of well-water arsenic (≥ 40.4 μg/L) and the GG genotype of AS3MT rs3740392 was associated with a difference of 40.9 μm (95% CI = 14.4, 67.5) in cIMT, much greater than the difference of cIMT associated with the genotype alone (β = -5.1 μm, 95% CI = -31.6, 21.3) or arsenic exposure alone (β = 7.2 μm, 95% CI = -3.1, 17.5). The pattern and magnitude of the interactions were similar when urinary arsenic was used as the exposure variable. Additionally, the at-risk genotypes of the AS3MT SNPs were positively related to the proportion of monomethylarsonic acid (MMA) in urine, which is indicative of arsenic methylation capacity. The findings provide novel evidence that genetic variants related to arsenic metabolism may play an important role in arsenic-induced subclinical atherosclerosis. Future replication studies in diverse populations are needed to confirm the findings.

  20. Study of the Relationship between Carotid Intima-media Thickness and Traditional Chinese Medicine Syndrome of Dyslipidemia

    Institute of Scientific and Technical Information of China (English)

    雷燕; 王振华; 赵浩; 刘剑刚

    2009-01-01

    Objective:The study aimed to explore the relationship between the carotid intima-media thickness (IMT),lipids,high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy) and other indices of laboratory and the traditional Chinese medicine(TCM) syndrome of dyslipidemia.Methods:A total of 152 dyslipidemia patients and 8 healthy people(taken as the control group) were recruited.According to the theory of the TCM syndrome,152 dyslipidemia patients were assigned to 4 groups:the stagnation of phlegm(SP) grou...

  1. Causes of Thickening of Carotid Intima-Media Thickness in Patients With Alcoholic Liver Disease: A Prospective Observational Study.

    Science.gov (United States)

    Qu, Bao-Ge; Wang, Hui; Liu, Yuan-Xun; Jia, Yi-Guo; Su, Ji-Liang; Wang, Zhong-Dong; Wang, Ya-Fei; Han, Xing-Hai; Pan, Jin-Dun; Guang-Ying

    2015-07-01

    differences were observed among the groups with respect to serum homocysteine, C-reactive protein (CRP), interleukin-6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), soluble OX40 ligand (sOX40L), or heat shock protein (HSP) 60 or 70. Alcoholic liver disease may result in CIMT thickening. Carotid intima-media thickness is associated with age and metabolic factors in patients with ALD. In addition, ALD might promote the premature occurrence of CIMT thickening. The thickening of carotid artery intima thickness, however, is not associated with cytokine profiles, oxidative balance, or immune responses in patients with ALD. PMID:26181540

  2. Evaluation of cardiac structure, function and carotid artery intima-media thickness in overweight people with color Doppler ultrasonography%彩色多普勒超声评价超重人群心脏结构、功能及颈动脉内-中膜厚度

    Institute of Scientific and Technical Information of China (English)

    薛甜; 朱向明; 李国杰; 张青陵; 吴晶晶

    2011-01-01

    Objective To investigate the influence of overweight on cardiovascular system with color Doppler ultrasonography . Methods Totally 100 people accepted health examination were included and classified into 2 groups according to body mass index (BMI) : Overweight group (BMI≥25 kg/m2, n= 53 ) and control group (BMI<25 kg/m2, n= 47) , both underwent color Doppler ultrasonography . The heart structure , heart function and carotid artery intima-media thickness (IMT ) of them were compared . Results Compared with control group , left ventricular diameter in end diastole (LVDD) ,interventricular septum thickness (IVST ), left ventricular posterior wall thickness (LVPWT ), left ventricular mass (LVM ) , left ventricular mass index (LVMI) , peak A velocity (A) and IMT of overweight group all increased , peak Evelocity (E) and E/A both decreased (all P< 0. 05) . In all of 100 people , LVDD , IVST , LVPWT . LVM , LVMI, A and IMT were all positively correlated with BMI , E/A and E were both negatively correlated with BMI . Conclusion Ultrasound examination showed that injury of left ventricle structure . relaxing function and intima-media thickness can occur in overw eight without clinical symptoms .%目的 应用彩色多普勒超声检查观察超重对心脏结构、功能及颈动脉内-中膜厚度(IMT)的影响.方法 根据体质量指数(BMI)将100名体检者分为正常对照组(BMI<25 kg/m2,47名)和超重组(BMI≥25 kg/m2,53名).对两组均行彩色多普勒超声心动图及颈动脉超声检查,分析超重对心脏结构、功能及颈动脉IMT的影响.结果 与正常对照组相比,超重组左心室舒张末期内径(LVDD)、左心室舒张末期室间隔厚度(IVST)、左心室后壁舒张末期厚度(LVPWT)、左心室质量(LVM)、左心室质量指数(LVMI)、二尖瓣舒张晚期峰值血流速度(A峰)、颈动脉IMT增高,二尖瓣舒张早期峰值血流速度(E峰)和E/A降低,差异均有统计学意义(P均<0.05).BMI与LVDD、IVST、LVPWT

  3. 脑梗死患者颈动脉内膜-中膜厚度与LDL、OX-LDL关系的研究%Study on intima-media thickness of carotid artery and relation between it and LDL or OX-LDL

    Institute of Scientific and Technical Information of China (English)

    毛善英; 刘建仁; 黄鉴政; 吴敏良; 毛显雅; 魏芳; 刘学明

    2001-01-01

    Objective To explore the level of artherosclerosis in carotid artery of cerebral infarction patients, analyse the relation between artherosclerosis and serum LDL,OX-LDL. Methods Determine the intima-media thickness(IMT) of carotid artery in cerebral infarction patiens and control. Measure low density lipoprotein(LDL) and oxided low density lipoprotein(OX-LDL) in their serum, Compare IMT and serum LDL,OX-LDL in cerebral infarction patients groups. Analyse the correlation between IMT and serum LDL,OX-LDL. Result IMT in the group of cerebral infarction accompanied diabetes was higher than the other groups . IMT was significantly positively correlated with LDL,OX-LDL. Conclusion Patients with cerebral infarction, especially those acompanied with diabetes have more severe artherosclerosis change in carotid artery. LDL,OX-LDL are crucial factors that could expedite artherosclerosis of carotid artery.%目的 研究脑梗死患者颈动脉粥样硬化的程度, 分析低密度脂蛋白(LDL)、氧化低密度脂蛋白(OX-LDL)与颈动脉粥样硬化的关系。方法 B超测定脑梗死组及对照组的颈动脉内膜-中膜厚度(intimal-media thickness;IMT)。测定受试者的LDL、OX-LDL。比较各脑梗死组及对照组的IMT和LDL、OX-LDL。对IMT和LDL、OX-LDL相关分析。结果 伴糖尿病的脑梗死组IMT高于其它脑梗死组及对照组。IMT与LDL、OX-LDL显著正相关。结论 脑梗死患者的颈动脉粥样硬化程度显著高于对照组; 其中伴有糖尿病的脑梗死患者的颈动脉粥样硬化程度尤为明显, LDL、OX-LDL是促进颈动脉粥样硬化的关键因子。

  4. Association of Microalbuminuria and Estimated Glomerular Filtration Rate With Carotid Intima-Media Thickness in Patients With Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Dehdashti Shahrokh

    2015-04-01

    Full Text Available Background Atherosclerosis is the main cause of cardiovascular diseases, and its risk enhances in type 2 diabetes mellitus. Objectives This study aimed to evaluate Carotid Intima-Media Thickness (CIMT by carotid artery ultrasonography and assess its correlation with microalbuminuria and estimated Glomerular Filtration Rate (eGFR in the patients with type 2 diabetes mellitus. Patients and Methods This cross-sectional study was included 205 patients with Type 2 Diabetes Mellitus (T2DM. We recorded clinical and biochemical data such as FBS, lipid profile, and urinary albumin. Intima-media thickness of carotid arteries was measured in all patients by high frequency ultrasound. Results In simple correlation coefficients analysis, CIMT was significantly associated with total cholesterol (r = 0.197, P = 0.008, serum creatinine (r = 0.240, P = 0.001, and urinary albumin (r = 0.420, P = 0.000. Also, CIMT elevated significantly with the stage progression of chronic kidney disease (0.67 ± 0.15 mm in stage 1, 0.73 ± 0.22 mm in stage 2, and 0.82 ± 0.21 mm in stage 3 (P value = 0.024. In multivariate linear regression analysis, the duration of diabetes, weight, HDL, serum creatinine, urinary albumin, and estimated Glomerular Filtration Rate (eGFR were independently associated with CIMT (P value < 0.05 for all. Conclusions Our study shows a relationship between CIMT and renal parameters, including eGFR and albuminuria. This study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors.

  5. The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

    Directory of Open Access Journals (Sweden)

    Akbas Halide S

    2010-08-01

    Full Text Available Abstract Background The role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1 is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects. Methods Thirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG, total cholesterol (TC, high-density lipoprotein (HDL-C and low-density lipoprotein cholesterol (LDL-C. We assessed CIMT by high-resolution ultrasound of both common carotid arteries. Results We found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014. We found that PON1

  6. Correlation of common carotid intima media thickness with atherosclerotic cardiovascular events in patients with type 2 diabetes mellitus

    International Nuclear Information System (INIS)

    Vascular complications are a major cause of morbidity and mortality in patients with diabetes mellitus and affect the quality of life. Atherosclerosis, which is the major underlying risk factor, is accelerated in diabetes. To reduce morbidity and mortality, identification of patients with a high risk for development of vascular events is necessary. Apart from other risk prediction models, detection of subclinical atherosclerosis at common carotid site by B-mode ultrasonography which is a noninvasive and reliable method, can add to the benefit and improve risk prediction. Population based studies have revealed that increased Common Carotid Intima Media Thickness (CCIMT) is associated with prevalent coronary artery disease and is a surrogate marker of cardiovascular events. Aim was to evaluate whether increased CCIMT is associated with increased risk of cardiovascular events in patients with type 2 diabetes. A total of 90 patients with type 2 diabetes who were included in the study, were divided in two groups. Group 1: without vascular events and group 2: with vascular events. Apart from patient's demographics, detailed history of events physical examination, through blood analysis for fasting, post postprandial blood sugar, serum cholesterol, TG, renal function test glycosylated Hb, chest x-ray, ECG were recoded. CCIMT was measured by B-mode ultrasonography using high frequency linear transducer, by a specialist radiologist (blind to all clinical and laboratory findings) by standard protocol as described in literature. Mean of the three readings in each side were used for statistical analysis. Our results showed that of the 90 patients studied, 45 diabetes mellitus (DM) patients had atherosclerotic events and significantly higher CCIMT value (mean value of 1.005 +- 0.17 mm) whereas as 45 comparable DM patients without sclerotic events and lower CCIMT values (0.798 +- 0.12 mm) (p0.99 mm) had a statistically significant association with high odds ratios for

  7. Evaluation of carotid intima-media thickness and flow-mediated dilatation in middle-aged patients with nonalcoholic fatty liver disease

    Directory of Open Access Journals (Sweden)

    Mohammadi A

    2011-11-01

    Full Text Available Afshin Mohammadi1, Homayoon Habibpur Sedani2, Mohammad Ghasemi-Rad31Department of Radiology, 2Student Research Committee, 3Genius and Talented Student Organization, Student Research Committee, Urmia University of Medical Sciences, Urmia, West-Azerbaijan, IranBackground: Nonalcoholic fatty liver disease (NAFLD has a high prevalence in the general population and is the most common liver disease in Western countries. It is a feature of metabolic syndrome and is characterized by excessive accumulation of fat in the liver cells.Methods: We examined 84 consecutive middle-aged (under 45 years patients with NAFLD and 65 control subjects matched for age, gender, and body mass index to determine carotid intima-media thickness (CIMT and flow-mediated dilatation (FMD in the brachial artery.Results: There was a statistically significant difference between CIMT and percentage increase in FMD in the patient group (P = 0.002; r = 0.33 when compared with the control group (P = 0.97; r = 0.005. The mean ± standard deviation CMIT was 0.65 ± 0.09 mm in patients and 0.55 ± 0.07 mm in controls. This difference was statistically significant (P = 0.001. Mean FMD in patients was 6.4% and 15.7% in controls. This difference was statistically significant (P = 0.001.Conclusion: This study shows that pure NAFLD without metabolic syndrome in middle-aged subjects is strongly associated with morphological (CIMT and physiological (FMD changes. These findings may have an important role in increasing cardiovascular risk in these patients.Keywords: nonalcoholic fatty liver disease, carotid intima-media thickness, flow-mediated dilatation

  8. Small, dense LDL particles predict changes in intima media thickness and insulin resistance in men with type 2 diabetes and prediabetes--a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Philipp A Gerber

    Full Text Available The association of small, dense low-density lipoprotein (sdLDL particles with an increased cardiovascular risk is well established. However, its predictive value with regard to glucose metabolism and arterial disease in patients with type 2 diabetes has not been thoroughly investigated. We conducted a prospective longitudinal cohort study in patients with (prediabetes who were seen at baseline and after two years. sdLDL particles were determined by gradient gel electrophoresis. Insulin resistance was estimated by using the homeostatic model assessment 2 (HOMA2. Intima media thickness (IMT and flow-mediated dilation (FMD were assessed by ultrasound measurements. Fifty-nine patients (mean age 63.0 ± 12.2 years were enrolled and 39 were seen at follow-up. IMT increased in the whole cohort during follow-up. The change in IMT was predicted by the proportion of sdLDL particles at baseline (p=0.03, and the change in FMD was predicted by LDL-cholesterol levels at baseline (p=0.049. HOMA2 and changes in HOMA2 correlated with the proportion of sdLDL particles and changes in this proportion, respectively (p<0.05 for both. Serum resistin levels increased in parallel with the increasing sdLDL particle number, while serum adiponectin increased only in patients with unaltered sdLDL particle number at follow-up (p<0.01 for both. In conclusion, the proportion of small, dense LDL particles and changes in this proportion are predictive of changes in intima media thickness and insulin resistance, and are closely associated with other determinants of an adverse metabolic status. Thus, this parameter extends the individual risk assessment beyond the limitations of traditional risk markers in patients with dysglycemia.

  9. 不同种类口服降糖药联用对2型糖尿病患者动脉内膜中层厚度和斑块发生的影响%Effects of combination of antidiabetic agents on artery intima-media thickness and plaque occurrence.

    Institute of Scientific and Technical Information of China (English)

    巴根; 王奇金; 缪雄; 丁长花; 冯正康; 黄勤; 邹大进

    2011-01-01

    目的 探讨不同种类口服降糖药联用对2型糖尿病患者动脉内膜中层厚度(intima-media thickness,IMT)和斑块发生率的影响.方法 选取初发2型糖尿病患者139例(2002年),将患者分为一种、两种、三种口服降糖药物单用组(SING、DOUB、TRIP)和不使用口服降糖药物组(NONE)及对照组.对比分析随访第6年(07年)和第8年(09年)各组颈动脉、髂动脉及股动脉的IMT值与斑块发生率以及其他临床指标的变化情况.结果 (1) TRIP组09年胰岛素(insulin,INS)水平与07相比略有降低.(2)TRIP组09年动脉IMT与07年相比有下降趋势,而对照组动脉IMT值显著升高(P<0.05).(3)TRIP组的动脉斑块发生率低于同期其他各组对应的动脉斑块发生率(P<0.05).(4)口服降糖药物联用种类与动脉斑块发生率具有明显相关性(P<0.05).(5)本研究证明INS是颈动脉斑块发生的危险因子(P<0.05),餐后2h血糖(2hPG)和INS为髂动脉斑块发生的危险因子(P<0.05).结论 罗格列酮+二甲双胍+格列吡嗪三种口服降糖药联用的三联疗法能控制胰岛素升高,延缓甚至逆转脉内膜增厚进程并且能够抑制动脉斑块发生,是较全面的防治2型糖尿病大血管病变的综合疗法.%Objective To investigate the change of artery intima-media thickness ( IMT) and plaque incidence in patients with type 2 diabetic in response to combination of antidiabetic agents. Methods Totally 139 newly diagnosed type 2 diabetic patients (2002) were divided into five groups; single-oral-hypoglycemic-therapy group (SING) ,double-oral-hypoglycemic-therapy group(DOUB) ,triple-oral-hypoglycemic-therapy group(TRIP) , none-oral-hypoglycemic-therapy group( NONE) and control group. The IMT as well as the plaque incidence in carotid artery, femoral artery and iliac artery together with other clinical indicators were measured and compared. Results (1) The INS of TRIP group at 09 slightly decreased compared with that at 07. ( 2 ) The

  10. Relation of Epicardial Fat Thickness with Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Mustafa Cetin

    2013-01-01

    Full Text Available Aims. The aim of this study was to investigate the relationship of echocardiographic epicardial fat thickness (EFT with carotid intima-media thickness (CIMT, in patients with type 2 diabetes mellitus (T2DM. Methods and Results. A total of 139 patients with T2DM (mean age 54.3 ± 9.2 and 49.6% male and 40 age and sex-matched control subjects were evaluated. Echocardiographic EFT and ultrasonographic CIMT were measured in all subjects. Patients with T2DM had significantly increased EFT and CIMT than those of the controls (6.0 ± 1.5 mm versus 4.42 ± 1.0 mm, P<0.001 and 0.76 ± 0.17 mm versus 0.57 ± 0.14 mm, P<0.001, resp.. EFT was correlated with CIMT, waist circumference, BMI, age, duration of T2DM, HbA1c in the type 2 diabetic patients. Linear regression analysis showed that CIMT (β=3.52, t=3.72, P<0.001 and waist circumference (β=0.36, t=2.26, P=0.03 were found to be independent predictors of EFT. A cutoff high risk EFT value of 6.3 mm showed a sensitivity and specificity of 72.5% and 71.7%, respectively, for the prediction of subclinical atherosclerosis. Conclusion. We found that echocardiographic EFT was significantly higher in patients with T2DM. Our study also showed that EFT was strongly correlated with waist circumference and CIMT as being independent of sex.

  11. Evaluation of periodontitis treatment effects on carotid intima-media thickness and expression of laboratory markers related to atherosclerosis.

    Science.gov (United States)

    Toregeani, Jeferson Freitas; Nassar, Carlos Augusto; Nassar, Patrícia Oehlmeyer; Toregeani, Krischina Mendes; Gonzatto, Geyssi Karolyne; Vendrame, Rafael; Castilhos, Jussimar Scheffer; Rotta, Larissa Sokol; Reinheimer, Andréia Carpenedo; Longoni, Anelise; Barcella, Mariana Waterkemper Andrade

    2016-01-01

    The objective of this research was to evaluate the treatment of periodontal disease and its effects on carotid intima-media thickness (CIMT) and expression of laboratory markers related to atherosclerosis. Twenty-three healthy patients (group 1) and 21 patients with moderate to severe periodontitis (group 2) underwent evaluation of clinical periodontal parameters. The patients were submitted to CIMT measurements and laboratory evaluations at the start of the study (0 months), 6 months, and 12 months. All patients received oral hygiene instruction; patients in group 2 also underwent supragingival and subgingival scaling and root planing. A statistically significant improvement in clinical periodontal parameters occurred in both groups (P periodontal instrumentation in group 2--were effective in improving clinical periodontal parameters of both groups and promoting reduction in CIMT at 6 months. PMID:26742169

  12. Carotid Intima-Media thickness progression and risk of vascular events in people with Diabetes: Results from the PROG-IMT collaboration

    NARCIS (Netherlands)

    M.W. Lorenz (Matthias); J.F. Price (Jackie F.); C.M. Robertson (Christine M); M.L. Bots (Michiel); J.F. Polak (Joseph F.); H. Poppert (Holger); M. Kavousi (Maryam); M. Dörr (Marcus); E. Stensland (Eva); P. Ducimetiere (Pierre); K. Ronkainen (Kimmo); S. Kiechl (Stefan); M. Sitzer (Matthias); T. Rundek (Tatjana); L. Lind (Lars); J. Liu (Jing); G. Bergstrom (Goran); L. Grigore (Liliana); L. Bokemark (Lena); A. Friera (Alfonsa); D. Yanez (David); H. Bickel (Horst); M.A. Ikram (Arfan); H. Volzke (Henry); S.H. Johnsen; J.P. Empana (Jean Philippe); T.-P. Tuomainen (Tomi-Pekka); J. Willeit (Johann); H. Steinmetz (Helmuth); M. Desvarieux (Moise); W. Xie (Wuxiang); C. Schmidt (Caroline); G.D. Norata (Giuseppe); C. Suárez (Carmen); D. Sander (Dirk); A. Hofman (Albert); U. Schminke (Ulf); E.B. Mathiesen (Ellisiv); M. Plichart (Matthieu); J. Kauhanen (Jussi); J. Willeit (Johann); R.L. Sacco (Ralph); S. McLachlan (Stela); D. Zhao (Dong); B. Fagerberg (Bjorn); A.L. Catapano (Alberico L.); R. Gabriel (Rafael); O.H. Franco (Oscar); A. Bulbul (Alpaslan); F. Scheckenbach (Frank); A. Pflug (Anja); L. Gao (Lu); S.G. Thompson (Simon G.)

    2015-01-01

    textabstractOBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated

  13. Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes : Results From the PROG-IMT Collaboration

    NARCIS (Netherlands)

    Lorenz, Matthias W.; Price, Jackie F.; Robertson, Christine; Bots, Michiel L.; Polak, Joseph F.; Poppert, Holger; Kavousi, Maryam; Doerr, Marcus; Stensland, Eva; Ducimetiere, Pierre; Ronkainen, Kimmo; Kiechl, Stefan; Sitzer, Matthias; Rundek, Tatjana; Lind, Lars; Liu, Jing; Bergstrom, Goran; Grigore, Liliana; Bokemark, Lena; Friera, Alfonsa; Yanez, David; Bickel, Horst; Ikram, M. Arfan; Voelzke, Henry; Johnsen, Stein Harald; Empana, Jean Philippe; Tuomainen, Tomi-Pekka; Willeit, Peter; Steinmetz, Helmuth; Desvarieux, Moise; Xie, Wuxiang; Schmidt, Caroline; Norata, Giuseppe D.; Suarez, Carmen; Sander, Dirk; Hofman, Albert; Schminke, Ulf; Mathiesen, Ellisiv; Plichart, Matthieu; Kauhanen, Jussi; Willeit, Johann; Sacco, Ralph L.; McLachlan, Stela; Zhao, Dong; Fagerberg, Bjorn; Catapano, Alberico L.; Gabriel, Rafael; Franco, Oscar H.; Buelbuel, Alpaslan; Scheckenbach, Frank; Pflug, Anja; Gao, Lu; Thompson, Simon G.

    2015-01-01

    OBJECTIVECarotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations

  14. Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance

    DEFF Research Database (Denmark)

    Lundby-Christensen, Louise; Tarnow, Lise; Hansen, Dorte L;

    2014-01-01

    AIM: To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS...

  15. Espessamento médio-intimal na origem da artéria subclávia direita como marcador precoce de risco cardiovascular Intima-media thickness in the origin of right subclavian artery as an early marker of cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Engelhorn

    2006-11-01

    EMI na origem da artéria subclávia direita pode ser considerado um marcador mais precoce para avaliação de risco cardiovascular.OBJECTIVE: Common carotid artery intima-media thickness (IMT is considered a factor of cardiovascular risk and an early marker of coronary artery disease. This study aimed to investigate the existence of a correlation between IMT in the carotid arteries and at the origin of the right subclavian artery, as well as to evaluate IMT in the subclavian artery as an earlier marker of cardiovascular risk. METHODS: One hundred and six consecutive patients, 52 males and 54 females, average age 51 years, underwent color Doppler ultrasonography to evaluate carotid and right subclavian arteries. The relationship between carotid IMT and right subclavian IMT was assessed using the Pearson's correlation coefficient analysis and a 95% confidence interval. Reliability of right subclavian artery IMT measurement for the diagnosis of early thickening (considering a > 0.8 mm carotid thickness as reference was described as to sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Cut-off values for the right subclavian IMT were indicated by the ROC curve, and p values 0.8 mm. The mean IMT value for the carotid artery was 0.87 mm (SD = 0.23 and for the subclavian artery, 1.17 mm (SD = 0.46, with a 0.31 correlation coefficient (95% CI: 0.12; 0.47. The ROC curve analysis indicated a cut-off value of 0.7 mm for the right subclavian artery IMT, using as reference a 0.8 mm cut-off value for the carotid artery (91% sensitivity, 27% specificity, 66% PPV, 65% NPV, and 66% accuracy. CONCLUSION: Our study showed that carotid artery IMT correlates well with right subclavian artery IMT. With a 0.7 mm cut-off value, it is possible to detect IMT in the right subclavian artery earlier than in the carotid arteries. The IMT at the origin of the right subclavian artery can be considered an earlier marker for the assessment of cardiovascular

  16. CAROTID INTIMA-MEDIA THICKNESS AND THE ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS IN THE ELDERLY

    Institute of Scientific and Technical Information of China (English)

    叶平; 王节; 尚延忠; 朱平

    2001-01-01

    Objective. To investigate the association of carotid arterial intima media thickness (IMT) with principal cardiovascular risk factors in the elderly. Methods. Carotid arterial IMT was measured by high resolution B mode ultrasound in 94 elderly subjects (old aged group), and compared with subjects aged < 60 (middle-aged group). Results. In comparison with the middle-aged group, the prevalence of coronary heart disease, cerebral vascular disease, hypertension and diabetes mellitus was significantly higher, and serum cholesterol and systolic blood pressure were also significantly higher in old aged group. Although there was no obvious difference in IMT between the two groups, carotid plaque and carotid wall thickening were more frequently found in old aged group. Age, systolic blood pressure and serum cholesterol were shown as the independent determinants for carotid IMT in the total participants, whereas no such independent relation was found in old-aged group. Conclusion. Age is the major risk factor for carotid atherosclerosis in the elderly. In other words, the occurrence of carotid atherosclerosis is the result of advancing age combined with the effect of multiple cardiovascular risk factors.

  17. Evaluating changes of carotid artery in patients with impaired glucose tolerance and type 2 diabetes mellitus with quantitative intima-media thickness and quantitative arterial stiffness%内中膜厚度定量及动脉僵硬度分析技术评价糖耐量减低及2型糖尿病者颈总动脉改变

    Institute of Scientific and Technical Information of China (English)

    谭丽芳; 艾红; 王娟; 石秀英; 淡敏

    2012-01-01

    目的 应用血管内中膜厚度定量(QIMT)及动脉僵硬度分析(QAS)技术评价糖耐量减低(IGT)和2型糖尿病(T2DM)患者颈总动脉结构及功能的改变.方法 对病例组68例患者[30例IGT(IGT亚组)和38例T2DM(T2DM亚组)]及58名正常对照(NC)组的右侧颈总动脉行QIMT、QAS及相关血清学检查,获取以下参数:内中膜厚度(IMT)、顺应性系数(CC)、扩张性系数(DC)、僵硬度参数(β)、2 h血糖值(2hPG)、甘油三酯(TG),胆固醇(Ch),低密度脂蛋白(LDL),糖化血红蛋白(GHb),并分析NC组与病例组各亚组之间的差异及相关性.结果 T2DM亚组DC低于NC组(P<0.05),其余参数组间两两比较差异均有统计学意义(P均<0.05);IGT和T2DM亚组β和IMT、2hPG、LDL与GHb均呈正相关(P均<0.01).结论 QIMT及QAS技术可反映动脉血管的早期结构及功能变化,对诊断IGT及T2DM患者早期动脉粥样硬化具有一定价值.%Objective To investigate the structural and functional changes of carotid artery in patients with type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) with quantitative intima-media thickness (QIMT) and quantitative arterial stiffness (QAS) technique. Methods The right side-of common carotid artery of 68 patients (30 IGT and 38 T2DM ) and 58 healthy controls (NC group) were examined with QIMT, QAS technique and relative serological testing. Parameters including triglyceride (TG), low-density lipoprotein ( LDL) , cholesterol (Ch), glycosylated hemoglobin (GHb), intima-media thickness (IMT), compliance coefficient (CO, distensibility coefficient (DC), stiffness index (β) and 2 h plasma glucose (2hPG) of carotid obtained were acquired and the statistically analyzed. Results DC in T2DM subgroup was lower than in NC group, while the other parameters all had statistical differences among groups (all P<0. 05). There was positive correlation between β and IMT, 2hPG. LDL, GHb in IGT and T2DM subgroup (all P<0. 01). Conclusion QIMT and QAS

  18. Cardiovascular risk factors and intima-media complex thickness in women of childbearing age with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    S A Polyakova

    2007-01-01

    Full Text Available Objective. To determine frequency and significance of traditional risk factors of cardiovascular pathology development and to assess features of carotids atherosclerotic damage in women of reproductive age with rheumatoid arthritis (RA. Material and methods. 85 women with RA (mean age 42,1±6,8 years and 32 healthy women (mean age 43,2±6,7 years were included. Traditional risk factors of cardiovascular diseases (CVD were examined. Blood lipid spectrum was assessed by content of total cholesterol (CTC, triglycerides (TG and high density lipoprotein cholesterol (HDLC. Low density lipoprotein cholesterol (LDLC and atherogenity index (AI were calculated. To reveal subclinical forms of atherosclerosis common carotid arteries (CCA duplex scanning with measurement of intima-media complex (IMC was performed using ultrasound system “Acuson 128/XP10” (USA by linear sensor with 7 MHz frequency. C- reactive protein (CRP was assessed by immuno-enzyme assay. Results. Hypertension and lipid metabolism disturbance were the most prevalent risk factors of development and progression of CVD in women of reproductive age with RA. Subclinical atherosclerosis characterized by thickening of IMC was more frequent in RA pts than in healthy women (p<0,001. Presence of extra-articular RA manifestations was accompanied by significant IMC thickening in the region of carotid artery bulb and internal carotid artery (p<0,001, p=0,003. Carotid artery IMC was significantly increased at 3rd RA activity degree in comparison with 1st activity degree (p=0,016 and in the presence of rheumatoid factor in serum (p=0,026. RA pts had IMC thickening irrespectively from CVD history. Conclusion. RA activity as well as HDLC, LDLC and CRP concentration are predictors of vascular atherosclerotic damage in RA

  19. Effects of active and passive smoking on the development of cardiovascular disease as assessed by a carotid intima-media thickness examination in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Jiang, Fei; Wang, Jie; Zhang, Rong; Chen, Miao; Peng, Danfeng; Sun, Xue; Yan, Jing; Luo, Yi; Tang, Shanshan; Hu, Cheng; Jia, Weiping

    2015-05-01

    Carotid intima-media thickness has been widely used as a surrogate end-point for cardiovascular disease, myocardial infarction, and stroke. This study aimed to assess the effects of active and passive smoking exposure on the development of cardiovascular disease in patients with type 2 diabetes mellitus. Seven hundred twenty-two patients with type 2 diabetes mellitus were recruited for the study. A standardized questionnaire on smoking status, pack-years of smoking, and the number of years of smoking cessation was provided to the patients, and their responses were collected for analysis. The carotid intima-media thickness, carotid plaque, and the internal diameter of the common carotid artery were determined by high-resolution B-mode ultrasonography. Compared to non-smokers, passive female smokers had a higher risk of cardiovascular disease (odds ratio = 3.50, 95% confidence interval: 1.29-9.49, P = 0.009); they also had a significantly larger common carotid artery (P = 0.041) and risk of carotid plaque (odds ratio = 2.20, 95% confidence interval: 1.1980-4.0505, P = 0.01). Both active and passive male smokers had a significantly greater carotid intima-media thickness than non-smokers (P = 0.003 and P = 0.005, respectively). Male active smokers had a significantly higher risk of carotid plaque (odds ratio = 2.88, 95% confidence interval: 1.4788-5.6094, P = 0.001). In conclusion, cumulative active and passive smoking exposures are significant risk factors for carotid atherosclerosis in patients with type 2 diabetes mellitus. Our results highlight the importance of endorsing a smoke-free environment for patients with type 2 diabetes mellitus.

  20. Effects of active and passive smoking on the development of cardiovascular disease as assessed by a carotid intima-media thickness examination in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Jiang, Fei; Wang, Jie; Zhang, Rong; Chen, Miao; Peng, Danfeng; Sun, Xue; Yan, Jing; Luo, Yi; Tang, Shanshan; Hu, Cheng; Jia, Weiping

    2015-05-01

    Carotid intima-media thickness has been widely used as a surrogate end-point for cardiovascular disease, myocardial infarction, and stroke. This study aimed to assess the effects of active and passive smoking exposure on the development of cardiovascular disease in patients with type 2 diabetes mellitus. Seven hundred twenty-two patients with type 2 diabetes mellitus were recruited for the study. A standardized questionnaire on smoking status, pack-years of smoking, and the number of years of smoking cessation was provided to the patients, and their responses were collected for analysis. The carotid intima-media thickness, carotid plaque, and the internal diameter of the common carotid artery were determined by high-resolution B-mode ultrasonography. Compared to non-smokers, passive female smokers had a higher risk of cardiovascular disease (odds ratio = 3.50, 95% confidence interval: 1.29-9.49, P = 0.009); they also had a significantly larger common carotid artery (P = 0.041) and risk of carotid plaque (odds ratio = 2.20, 95% confidence interval: 1.1980-4.0505, P = 0.01). Both active and passive male smokers had a significantly greater carotid intima-media thickness than non-smokers (P = 0.003 and P = 0.005, respectively). Male active smokers had a significantly higher risk of carotid plaque (odds ratio = 2.88, 95% confidence interval: 1.4788-5.6094, P = 0.001). In conclusion, cumulative active and passive smoking exposures are significant risk factors for carotid atherosclerosis in patients with type 2 diabetes mellitus. Our results highlight the importance of endorsing a smoke-free environment for patients with type 2 diabetes mellitus. PMID:25708055

  1. Association of Exposure to Particular Matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Xiaole Liu

    2015-10-01

    Full Text Available Background: Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM2.5 and PM10 have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT. Methods: Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI. The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. Results: Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 μg/m3 in PM2.5 and PM10 were associated with an increase of CIMT (16.79 μm; 95% CI, 4.95–28.63 μm and 4.13 μm; 95% CI, −5.79–14.04 μm, respectively. Results shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. Conclusions: Exposure to PM2.5 had a significant association with CIMT and for women the effect may be more obvious.

  2. Relationship between Waist Circumference and Elevation of Carotid Intima-media Thickness in Newly-diagnosed Diabetic Patients

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; JIA Wei Ping; SHEN Yun; ZHOU Jian; PAN Jie Min; YU Hao Yong; CHEN Hai Bing; LI Qing; LI Ming; BAO Yu Qian

    2014-01-01

    Objective Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The present study was aimed to find out the relationship between waist circumference and carotid intima media thickness (C-IMT), as well as the best waist circumference cutoff for identifying C-IMT elevation in Chinese male patients with newly-diagnosed diabetes. Methods Five hundred and seventy-eight patients from Department of Endocrinology and Metabolism in Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University were enrolled. Both physical examination (for measurement of waist circumference) and carotid ultrasonography (for measurement of C-IMT) were performed. Results After grouping according to the quartiles of C-IMT, the waist circumference increased across all its quartiles. The waist circumference in 3rd and 4th quartiles (90.7±9.8 cm and 90.8±9.6 cm) was significant higher than in 1st and 2nd quartiles (P Conclusion Among newly-diagnosed diabetic male patients, waist circumference over 90 cm not only reflects sub-clinical atherosclerosis in early stage, but also predicts the progression of atherosclerosis.

  3. Dialysis methods may affect carotid intima-media thickness in Chinese end-stage renal disease patients.

    Science.gov (United States)

    Shi, Zhanqin; Zhu, Ming; Guan, Jianming; Chen, Jianghua; He, Qiang; Zhang, Xiaohui; Zhu, Shaoming; Song, Xuequan; Wang, Xiaoyi; Jiang, Zhiqiang

    2012-01-01

    Atherosclerosis is the most common cause of cardiovascular morbidity in end-stage renal disease (ESRD) patients and carotid intima-media thickness (IMT) is an early independent predictor of atherosclerosis. The aim of this study is to compare the continuous ambulatory peritoneal dialysis (CAPD) and the maintenance hemodialysis (MHD) for carotid IMT in Chinese ESRD patients. A total of 72 CAPD patients, 92 MHD patients, and 50 age- and sex-matched healthy controls were included. Dialysis patients were divided into five subgroups according to dialysis duration: 3-6, 7-12, 13-59, 60-119, and 120-179 months. Carotid IMT and carotid plaques were detected for each patient. The carotid IMT and total plaque detection rate in the CAPD and MHD groups were considerably higher than in the healthy control group (p  0.05). However, after stratification by dialysis duration, the total carotid IMT in the CAPD subgroup was higher than in the MHD subgroup in dialysis duration of 60-119 and 120-179 months (p  0.05). Our study showed that both CAPD and MHD affect carotid IMT in Chinese ESRD patients, and the degree of atherosclerosis in CAPD patients might be higher than that in MHD patients after 5 years of dialysis.

  4. Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness.

    Science.gov (United States)

    Strawbridge, Rona J; Hilding, Agneta; Silveira, Angela; Österholm, Cecilia; Sennblad, Bengt; McLeod, Olga; Tsikrika, Panagiota; Foroogh, Fariba; Tremoli, Elena; Baldassarre, Damiano; Veglia, Fabrizio; Rauramaa, Rainer; Smit, Andries J; Giral, Phillipe; Kurl, Sudhir; Mannarino, Elmo; Grossi, Enzo; Syvänen, Ann-Christine; Humphries, Steve E; de Faire, Ulf; Östenson, Claes-Göran; Maegdefessel, Lars; Hamsten, Anders; Bäcklund, Alexandra

    2016-10-01

    Type 2 diabetes and cardiovascular disease are complex disorders involving metabolic and inflammatory mechanisms. Here we investigated whether sCD93, a group XIV c-type lectin of the endosialin family, plays a role in metabolic dysregulation or carotid intima-media thickness (IMT). Although no association was observed between sCD93 and IMT, sCD93 levels were significantly lower in subjects with type 2 diabetes (n = 901, mean ± SD 156.6 ± 40.0 ng/mL) compared with subjects without diabetes (n = 2,470, 164.1 ± 44.8 ng/mL, P high-fat diet. The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases. We further demonstrated that stress-induced release of sCD93 is impaired by hyperglycemia. Therefore, we propose CD93 as an important component in glucometabolic regulation. PMID:27659228

  5. Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice

    OpenAIRE

    Masoud Alasvand; Bahman Rashidi; Shaghayegh Haghjooy Javanmard; Majid Khazaei

    2015-01-01

    Objective(s): Atherosclerosis is an important risk factor for coronary heart disease. Neuropeptide Y (NPY) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage. The role of NPY in atherosclerosis has not yet been fully studied, so this study was conducted to further investigate the effect of BIIE 0246, an NPY receptor antagonist, on aortic intima-media thickness and size and number of adipocyte cells in normal and obese mice...

  6. Is the association between job strain and carotid intima-media thickness attributable to pre-employment environmental and dispositional factors? The Cardiovascular Risk in Young Finns Study.

    OpenAIRE

    Hintsa, T; Kivimäki, M; Elovainio, M; Vahtera, J; Hintsanen, M.; Viikari, J S; Raitakari, O. T.; Keltikangas-Järvinen, L.

    2008-01-01

    OBJECTIVES: Most previous studies of job strain and cardiovascular risk have been limited to adult data. It remains unclear whether this association might be explained by factors already present before entering the labour market. This study examined whether pre-employment family factors and participants' own dispositional factors contribute to the relationship between job strain and carotid intima-media thickness (CIMT) among male employees. METHODS: The sample consisted of 494 men from the C...

  7. Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice

    Directory of Open Access Journals (Sweden)

    Masoud Alasvand

    2015-05-01

    Full Text Available Objective(s: Atherosclerosis is an important risk factor for coronary heart disease. Neuropeptide Y (NPY and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage. The role of NPY in atherosclerosis has not yet been fully studied, so this study was conducted to further investigate the effect of BIIE 0246, an NPY receptor antagonist, on aortic intima-media thickness and size and number of adipocyte cells in normal and obese mice. Materials and Methods: Tests were performed on 24 male C57BL/6 mice. The animals were divided into four groups as follows: control (normal, obese (high-fat diet, normal+NPY receptor antagonist (1 μM, 100 µl/Kg BIIE0246 intraperitoneally and obese+NPY receptor antagonist (n=6 each. After 14 days, the animals were sacrificed and epididymal adipose tissue and thoracic aorta were removed. Evaluations were made for adipocyte cell number and size and for aortic intima-media thickness. Results: The group on a high-fat diet showed a significantly decreased number of adipocyte cells and increased cell size (P0.05. Conclusion: NPY receptor antagonist had no effect on adipocyte cell size and aortic intima-media thickness; however, it decreased cell number in the normal group indicating likely involvement in the progression of obesity

  8. Carotid Intima-Media Thickness in Indonesian Subjects with Cardiovascular Disease Risk Factors Who Were Not Receiving Lipid-Lowering Agents.

    Science.gov (United States)

    Kaligis, Rinambaan W M; Adiarto, Suko; Nugroho, Johanes; Pradnyana, Bagus Ari; Lefi, Achmad; Rifqi, Sodiqur

    2016-09-01

    Carotid intima-media thickness (CIMT) is frequently utilized for detection of subclinical atherosclerosis. This study aims to investigate the association between the CIMT values and demographic characteristics, cardiovascular disease (CVD) risk factors, lipid biochemistry profiles, and high-sensitivity C-reactive protein (hs-CRP) levels among the Indonesian population. Subjects who had two or more CVD risk factors but were not receiving lipid-lowering therapy were recruited from six hospitals of Indonesia. Measurements of CIMT are obtained by ultrasonography of 12 sites within the common carotid artery. CVD risk factors, lipid and glucose profiles, and hs-CRP values were analyzed with respect to distribution of CIMT. The mean-max CIMT was 0.805 ± 0.190 mm (minimum, 0.268 mm; maximum, 1.652 mm) and the mean-mean CIMT was 0.614 ± 0.190 mm (minimum, 0.127 mm; maximum, 1.388 mm). Multivariate analyses confirmed an independent association between increasing CIMT and increasing age (regression coefficient = 0.004; p = 0.004). Our data show normative mean-mean CIMT data for Indonesian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk stratification of asymptomatic individuals in Indonesia.

  9. Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?

    Directory of Open Access Journals (Sweden)

    Tarantino Giovanni

    2012-03-01

    Full Text Available Abstract Background Hepatic steatosis (HS has been associated with obesity and metabolic syndrome (MS, conditions carrying a high risk of coronary artery disease. We aimed to determine whether HS was an independent factor of atherogenic risk beyond its association with MS and its components. Methods We assessed the circulating levels of the heat shock protein-70 (HSP-70, a chaperone involved in inflammation, endoplasmic reticulum stress and apoptosis at liver and endothelial level and the gamma-glutamyl transferase activity (γ-GT correlating them to carotid intima-media thickness (IMT, along with lipid profile, HOMA, C-reactive protein, fibrinogen, ferritin, adiposity type as well as spleen volume in 52 obese pts with grade 1, 128 with grade 2, and 20 with grade 3 of HS evaluated by sonography. Results Patients with different grade of HS demonstrated overlapping HSP-70 levels; similarly performed obese subjects regarding IMT. Using multiple regression analysis, IMT was predicted by age, visceral adiposity and by HOMA (β = 0.50, p p = 0.01 and β = 0.18, p = 0.048 respectively, while the severity of HS was predicted by visceral and subcutaneous adiposity and HOMA (β = 0.50, p p = 0.001 and β = 0.18, p = 0.024, respectively. Conclusion In our series of patients with normal or mild elevation of γ-GT, the severity of HS does not entail higher IMT, which may be linked to MS stigmata.

  10. Carotid Intima-Media Thickness in Indonesian Subjects with Cardiovascular Disease Risk Factors Who Were Not Receiving Lipid-Lowering Agents.

    Science.gov (United States)

    Kaligis, Rinambaan W M; Adiarto, Suko; Nugroho, Johanes; Pradnyana, Bagus Ari; Lefi, Achmad; Rifqi, Sodiqur

    2016-09-01

    Carotid intima-media thickness (CIMT) is frequently utilized for detection of subclinical atherosclerosis. This study aims to investigate the association between the CIMT values and demographic characteristics, cardiovascular disease (CVD) risk factors, lipid biochemistry profiles, and high-sensitivity C-reactive protein (hs-CRP) levels among the Indonesian population. Subjects who had two or more CVD risk factors but were not receiving lipid-lowering therapy were recruited from six hospitals of Indonesia. Measurements of CIMT are obtained by ultrasonography of 12 sites within the common carotid artery. CVD risk factors, lipid and glucose profiles, and hs-CRP values were analyzed with respect to distribution of CIMT. The mean-max CIMT was 0.805 ± 0.190 mm (minimum, 0.268 mm; maximum, 1.652 mm) and the mean-mean CIMT was 0.614 ± 0.190 mm (minimum, 0.127 mm; maximum, 1.388 mm). Multivariate analyses confirmed an independent association between increasing CIMT and increasing age (regression coefficient = 0.004; p = 0.004). Our data show normative mean-mean CIMT data for Indonesian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk stratification of asymptomatic individuals in Indonesia. PMID:27574385

  11. Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant

    DEFF Research Database (Denmark)

    Boardman-Pretty, Freya; Smith, Andrew J. P.; Cooper, Jackie;

    2015-01-01

    Carotid intima-media thickness (IMT) is a marker of subclinical atherosclerosis that can predict cardiovascular disease events over traditional risk factors. This study examined the BCAR1-CFDP1-TMEM170A locus on chromosome 16, associated with carotid IMT and coronary artery disease in the IMT and...... with slower IMT progression in women (P=0.04) but not in men. Meta-analysis of 5 cohort studies also supported a protective effect of the A allele on common carotid IMT in women only (women: β=-0.0047, P=1.63×10-4; men: β=-0.0029, P=0.0678). Two hundred fourteen noncoding variants in strong linkage...... associations of rs4888378 with BCAR1 in vascular tissues. Molecular studies suggest the lead SNP as a potentially causal SNP at the BCAR1-CFDP1-TMEM170A locus, and expression quantitative trait loci studies implicate BCAR1 as the causal gene. This variant showed stronger effects on common carotid IMT in women...

  12. A Family History of Stroke Is Associated with Increased Intima-Media Thickness in Young Ischemic Stroke - The Norwegian Stroke in the Young Study (NOR-SYS)

    Science.gov (United States)

    Øygarden, Halvor; Fromm, Annette; Sand, Kristin Modalsli; Kvistad, Christopher Elnan; Eide, Geir Egil; Thomassen, Lars; Naess, Halvor; Waje-Andreassen, Ulrike

    2016-01-01

    Background and Purpose Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. Methods First-degree FH of CVD was assessed in ischemic stroke patients ≤ 60y using a standardized interview. Carotid ultrasound was performed and far wall cIMT in three carotid artery segments was registered, representing the common carotid (CCA-IMT), carotid bifurcation (BIF-IMT) and the internal carotid artery (ICA-IMT). Measurements were compared between FH+ and FH negative groups and stepwise backward regression analyses were performed to identify factors associated with increased cIMT. Results During the study period 382 patients were enrolled, of which 262 (68%) were males and 233 (61%) reported FH of CVD. Regression analyses adjusting for risk factors revealed age as the most important predictor of cIMT in all segments. The association between FH+ and cIMT was modified by age (p = 0.014) and was significant only regarding ICA-IMT. FH+ was associated with increased ICA-IMT in patients aged < 45y (p = 0.001), but not in patients ≥ 45y (p = 0.083). The association with ICA-IMT was present for a FH of stroke (p = 0.034), but not a FH+ of CHD or PAD. Conclusions FH of stroke is associated with higher ICA-IMT in young ischemic stroke patients. Subtyping of cardiovascular FH is important to investigate heredity in young ischemic stroke patients. Trial Registration ClinicalTrials.gov NCT01597453 PMID:27504830

  13. Comparison of flow-mediated brachial artery dilatation and carotid intima-media thickness in the diagnosis of coronary artery disease%流量介导的肱动脉扩张与颈动脉内中膜厚度对冠心病诊断作用比较

    Institute of Scientific and Technical Information of China (English)

    金修才; 赵宝珍

    2006-01-01

    目的:冠心病患者流量介导的肱动脉扩张(flow-mediated vasodilation,FMD)减低,颈动脉内中膜厚度(intima-media thickness,IMT)增厚,但两者对冠心病是否具有诊断作用尚未可知,本文主要探讨肱动脉FMD与颈动脉IMT对冠心病有无诊断作用.方法:在具有冠心病危险因素、具有典型的冠心病临床表现而且行冠状动脉造影检查的患者中,选取50位经冠状动脉造影明确患有冠心病的患者作为冠心病组,50位经冠状动脉造影检查明确没有冠心病的患者作为对照组,分别测量每位患者的肱动脉FMD和颈动脉IMT,通过单因素分析及多因素分析观察两者对冠心病的诊断作用.结果:冠心病组的肱动脉FMD较对照组低,颈动脉IMT较对照组厚,单因素分析发现高脂血症、糖尿病、肱动脉FMD以及颈动脉IMT与冠心病的发生密切相关,而在多因素回归分析中,仅有肱动脉FMD与冠心病的发生密切相关,以FMD<6%为标准,其对冠心病的诊断的敏感性为92%,特异性为88%.结论:肱动脉FMD对冠心病具有诊断价值,IMT则不能用来诊断冠心病.

  14. Correlation between coronary artery SYNTAX integra and estimated glomerular filtration rate and carotid intima-media thickness in eldly patients with coronary artery disease%冠状动脉SYNTAX积分与内生肌酐清除率及颈动脉内膜中层厚度的相关性

    Institute of Scientific and Technical Information of China (English)

    申琳

    2014-01-01

    目的:探讨老年冠心病患者冠状动脉(冠脉)SYNTAX积分与肾小球滤过率估算值(estimated glo-merular filtration rate,eGFR)及颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)的关系.方法:回顾性分析在我院经造影证实3支病变和(或)左主干病变的老年冠心病患者43例,计算SYNTAX积分并进行危险分层,利用Cockcroft-Gault公式计算eGFR,采用超声测定CIMT,分析患者SYNTAX积分与eGFR及CIMT的关系.多元线性回归分析法分析影响SYNTAX积分的危险因素.结果:老年冠心病患者SYNTAX评分与eGFR呈负相关(r=一0.36,P<0.05);SYNTAX评分与CIMT呈正相关(r=0.33,P<0.05);CIMT与eGFR负相关(r=-0.47,P<0.05).将患者以SYNTAX积分(低危0~22分,中危23~32分,高危≥33分)进行分层分析,低危组与中危组、低危组与高危组CIMT差异有统计学意义(P<0.05),低危组与中危组及高危组eGFR差异有统计学意义(P<0.05).eGFR(β=-0.1834,P=0.002 4)是SYNTAX积分的独立危险因素.结论:颈动脉内膜的变化与冠脉病变相关;随着老年冠心病患者肾脏功能的减退,动脉粥样硬化有逐渐加重的趋势.

  15. Gender specific association of neonatal characteristics and cardiovascular risk factors on carotid intima-media thickness in a Chinese cohort

    Institute of Scientific and Technical Information of China (English)

    LIN Xue; ZHU Wen-ling; TAN Li; XU Tao; XU Rui-yi; FANG Quan; ZHANG Shu-yang; ZHANG Zhen-xin

    2010-01-01

    Background Multiple neonatal characteristics and adult cardiovascular risk factors are associated with the development of atherosclerosis, however little conclusive evidence exists characterizing the relative strength of these factors. In a large retrospective study, we investigated the association between both objective neonatal measurements and comprehensive adult cardiovascular risk factors with the development of atherosclerosis, quantified by carotid intima-media thickness (CIMT). Further, we assessed the impact of gender on the relative impact of these risk factors.Methods CIMT, a measure of atherosclerosis, was determined by carotid ultrasound on 1568 participants (age 50-85)whose birth records were obtained from Peking Union Medical College Hospital. In addition, each participant was given a physical examination, and completed a medical questionnaire to identify a panel of cardiovascular risk factors. Multiple regression analysis was performed on the population and on the male and female cohorts individually, to identify the relative contribution of these risk factors to increased CIMT.Results For the total population the Framingham score, renal function, adult abdominal circumference and mother's gestational age were associated with CIMT, accounting for 14.7%, 1.4%, 0.9%, and 0.2% of total variance, respectively.In the male population the Framingham score, renal function, abdominal circumference and hemoglobin were the most significant risk factors for CIMT. Risk in the female population was associated with Framingham score, renal function,insulin resistance and gestational age. No relationship between birth weight or head circumference and CIMT were observed.Conclusions Adult cardiovascular risk factors were the most significantly associated with the development of atherosclerosis; however mother's age at birth was associated with CIMT, particularly in the female cohort. The relative contribution of the risk factors analyzed varied between the male and

  16. Cholesteryl ester transfer protein, low density lipoprotein particle size and intima media thickness in patients with coronary heart disease.

    Science.gov (United States)

    Tosheska, Katerina; Labudovic, Danica; Jovanova, Silvana; Jaglikovski, Branko; Alabakovska, Sonja

    2011-08-01

    Cholesteryl ester transfer protein (CETP) plays a key role in reverse cholesterol transport and high density lipoprotein (HDL) metabolism. Predominance of small, dense LDL particles is associated with an increased risk of atherosclerosis and coronary heart disease (CHD).The aim of the study was to determine the potential relationship between the CETP concentration and low density lipoprotein (LDL) particle size and their association with intima media thickness (IMT) in patients with CHD. Lipid parameters, CETP concentration and LDL particle size were determined in 100 healthy subjects (control group) and in 100 patients with CHD, aged 43 to 77 years. Plasma CETP concentrations were measured by an enzyme-linked immuno-sorbent assay with two different monoclonal antibodies. LDL subclasses were separated by nondenaturing polyacrilamide 3-31% gradient gel electrophoresis. CETP concentration was higher in patients compared to controls (2.02 ± 0.75 mg/ml vs. 1.74 ± 0.63 mg/ml, p<0.01). Mean LDL particle size (nm) was significantly smaller in patients than in controls (24.5 ± 1.1 vs. 26.1 ± 0.9; p<0.001). There was no relation between LDL particle size and CETP concentration (r=-0.1807, p=0.072). Age, diastolic blood pressure, CETP concentration and LDL particle size were independent factors for determing IMT by multiple linear regression analysis. They accounted for 35.2 % of the observed variability in IMT. CETP is not an independent contributor of LDL particle size. CETP might play a role in determining lipoprotein distributions, but did not seem to be the sole factor in the formation of small LDL particles.

  17. Appropriateness of carotid plaque and intima-media thickness assessment in routine clinical practice

    Directory of Open Access Journals (Sweden)

    Alessi Alexandre

    2008-10-01

    Full Text Available Abstract Objectives To describe the findings and evaluate appropriateness of a carotid artery study including the measurement of IMT, the presence of atherosclerotic plaque, and their correlation with cardiovascular risk factors. Methods 555 patients (220 men; 67.06 ± 12.44 years were included in the study. 120 patients (21.62% presented carotid plaque: 108 (19.45% in patients with at least one risk factor and 12 (2.1% in patients without risk factors. With respect to appropriateness of the present studies: 65% were appropriate, 22% were uncertain and 13% were inappropriate. The IMT medians were higher in males (0.0280; 95% CI, 00.82 to 0.478; p = 0.0057 and in hypertensive patients (0.391; 95% CI, 0.0190 to 0.0592; p = 0,001. There was a linear increase in mean IMT for each year increased in age (0.0059; 95% CI; 0.0050 to 0.0067. Carotid plaque was more frequent in patients with CAD (p = 0.0002, diabetes (p = 0.024 and hypertension (p = 0.036. Conclusion Assessment of carotid arteries identified increased incidence of plaque in patients with CAD, diabetes and hypertension. IMT was increased in older patients, hypertensive patients and males. Forty-five percent of the patients were studied based on uncertain and inappropriate reasons.

  18. Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice

    Directory of Open Access Journals (Sweden)

    Kottarappat N. Dileepan

    2004-01-01

    Full Text Available STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sld mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sld mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sld genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sld mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sld mice.

  19. Intima media thickness measurement in children: A statement from the Association for European Paediatric Cardiology (AEPC) Working Group on Cardiovascular Prevention endorsed by the Association for European Paediatric Cardiology.

    Science.gov (United States)

    Dalla Pozza, Robert; Ehringer-Schetitska, Doris; Fritsch, Peter; Jokinen, Eero; Petropoulos, Andreas; Oberhoffer, Renate

    2015-02-01

    Atherosclerosis causing cardiovascular disease is the most common cause of death in the developed world. Early precursors of vascular changes - subclinical atherosclerosis - warrant special attention as this process can be stabilized or even reversed if treated in time. Sonographic Intima Media Thickness measurement of the carotid artery (cIMT: carotid Intima-Media-Thickness) is considered a valid surrogate marker for cardiovascular risk allowing assessment of atherosclerotic changes at a very early stage. It is easy to apply due to its non-invasive character. Moreover, cIMT has been proven to provide reliable and reproducible results both in adult and adolescent patients. For the paediatric age group, several characteristics deserve special consideration. The heterogeneity of techniques of scanning, measurement and interpretation impede the comparison and interpretation of IMT values so far. Also, age- and sex-dependent normative data have to be considered for interpretation. Thus, the Association for European Paediatric Cardiology (AEPC) Working Group on Cardiovascular Prevention concludes to refer a statement on cIMT scanning, measurement and interpretation with special focus on paediatric patients. This statement includes an overview on normative data available as well as a practical guideline for the setting, scanning, measurement and interpretation of IMT values. Synchronizing different measurement methods will allow for comparing the results of several research centers. By that, in a large patient number, sufficient information may be given to assess the long-term endpoints of cardiovascular morbidity and mortality.

  20. Prevalence and risk factors of carotid intima-media thickness in asymptomatic individual subjects in a tertiary care center in India

    Directory of Open Access Journals (Sweden)

    Subhash Kaul

    2015-01-01

    Full Text Available Background: Carotid intima-media thickness (IMT is increasingly identified as a marker of atherosclerosis and increased risk of cerebrovascular disease. Aim: We aimed to investigate the prevalence of carotid IMT in asymptomatic Indian individuals, more than 40 years of age, and correlate it with other risk factors for cerebrovascular ischemia. Materials and Methods: Individuals attending outpatient services of Nizam′s Institute of Medical Sciences, who were asymptomatic for cerebrovascular ischemia underwent detailed history and carotid Doppler examination. IMT on mid common carotid artery (CCA was measured. All subjects′ blood was taken for biochemical estimation of fasting blood sugar and total cholesterol levels. Results: Out of 1,392 subjects, 571 (41% had abnormal IMT and 821 (59% had normal IMT. On comparison of the two groups, the factors significantly associated with abnormal IMT were mean older age (59 vs 50.7 years; P < 0.0001 and higher prevalence of hypertension (257 (45% vs 236 (28.7%; P < 0.0001, diabetes (159 (27.8% vs 139 (16.9%; P < 0.0001, and hypercholesterolemia (124 (21.7% vs113 (13.7%; P = 0.0001. After adjustment with multiple logistic regression, significant predictors were age (odds 3.2; 95% confidence interval (CI 2.5-4.1, male gender (odds 1.5; 95% CI 1.1-1.9, hypercholesterolemia (odds 1.5; 95% CI 1.1-2.0, hypertension (odds 1.4; 95% CI 1.1-1.8, and diabetes (odds 1.3; 95% CI 1.0-1.7. Conclusion: We found age, sex, hypertension, diabetes, and hypercholesterolemia to be independent risk factor for abnormal IMT in asymptomatic subjects over 40 years of age.

  1. Nontraditional Cardiovascular Biomarkers and Estimation of Cardiovascular Risk in Predialysis Chronic Kidney Disease Patients and Their Correlations With Carotid Intima Media Thickness

    OpenAIRE

    Sathi, Satyanand; Mahapatra, Himanshu; Sunder, Sham; Jayaraman, Rajesh; Sharma, Neera; Verma, Himanshu; Krishnamoorthy, Venkataramanan; Gupta, Anurag; Kanchi, Prabhu; Daksh, Sunil; Pursnani, Lalit; Shadab, Faisal; Singh, Manveer

    2014-01-01

    Background: Cardiovascular biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), hs-CRP (high sensitivity C-reactive protein), and albuminuria predict underlying heart disease in the general population as well as CKD patients. Objectives: We aimed to study the association of NT-proBNP, cTnT, hs-CRP, and spot urine albumin creatinine ratio with carotid intima media thickness (CIMT) for cardiovascular risk estimation in predialysis CKD (chronic kid...

  2. 脉压增大的高血压患者脉搏波传导速度、颈动脉内膜中层厚度和踝臂指数的检测现状%Examination status of pulse wave velocity, carotid artery intima-media thickness and ankle-brachial index in hypertensive patients with increased pulse pressure

    Institute of Scientific and Technical Information of China (English)

    隋辉; 马丽媛; 刘明波; 王文

    2014-01-01

    目的:了解脉压增大(脉压≥50 mmHg,1mmHg=0.133kPa)的高血压患者脉搏波传导速度(PWV)、颈动脉内膜中层厚度(IMT)和踝臂指数的检测现状。方法2011年4月至2012年9月,选取中国北部、南部和西部的96个大、中、小城市的709家医院进行的大型横断面调查。入选脉压增大(脉压≥50 mmHg)的高血压患者36259例。根据患者的血压水平、危险因素数量、靶器官损害和心血管疾患分为低危、中危、高危和很高危。根据脉压分为50~60 mmHg,60~70 mmHg和≥70 mmHg三层。询问病史(心血管病、脑血管病、肾脏病和糖尿病史)、吸烟史;记录PWV、IMT和踝臂指数的检查情况。现场测量血压、身高、体重、腰围。结果患者IMT、PWV和踝臂指数的检查率分别为20.7%、8.8%和7.8%,即未做IMT、PWV和踝臂指数检查的患者分别为79.3%、91.2%和92.2%。进一步分析,在检查的患者中, IMT(≥0.9 mm和粥样斑块)、PWV(>12 ms)和踝臂指数(≤0.9)异常的检出率分别为65.7%、40.9%和47.4%。IMT、PWV和踝臂指数异常的检出率在高危患者中分别为86.8%、68.5%和22.9%,在很高危患者中分别为66.1%、40.2%和48.2%。脉压50~60 mmHg,60~70 mmHg和≥70 mmHg组的IMT异常的检出率分别是39.3%,66.6%和80.7%;PWV异常的检出率分别是24.6%,43.0%和59.0%。结论我国城市中,脉压增大(≥50 mmHg)的高血压患者血管病变相关项目的检测率低。%Objective To get to know the examination status of pulse wave velocity (PWV), carotid artery intima-media thickness (CA-IMT) and ankle-brachial index (ABI) in hypertensive patients with increased pulse pressure (≥50 mmHg).Methods A large-scale cross-sectional survey was carried out in 709 hospitals in 96 large, medium and small cities in North, South and West China from Apr. 2011 to Sept. 2012. The patients (n=36259) were chosen and divided into low risk group, mid

  3. THE LATENT INTERCONNECTION OF THE FACTORS OF ATHEROSCLEROSIS PROGRESSION WITH A THICKNESS OF INTIMA-MEDIA BY USE OF MULTIDIMENSIONAL STATISTICAL METHODS ANALYSIS

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2011-01-01

    Full Text Available The aim – the study of latent relationships between indicators of the thickness of intima-media (CMM and infectious, immune, inflammatory and metabolic factors in patients with varying degrees of severity of vascular changes in these multivariate methods of statistical analysis.Materials and methods. Study included 220 patients (mean age – 43,9 ± 0,5 years who were divided into 3 groups. Group 1 consisted of thepatients with no risk factors of cardiovascular disease (CVD, the 2nd – the presence of the above factors, in third – with atherosclerotic plaques in the carotid artery. Every patient had conducted a comprehensive survey, which included an ultrasound of vessels on the apparatus Aloka 5000 with the measurement of the thickness of KIM, the study of lipid panel, the definition of C-reactive protein and cytokines – tumor necrosis factor-α, interferon-γ, interleukin-1, -8, -4, antibodies to cytomegalovirus immunoglobulin (CMV, herpes simplex virus type 1, C. pneumoniae, H. pylori and β-hemolytic streptococcus group A. The immune system status was assessed by indicators of innate and acquired immunity.Results. According to cluster analysis, all groups of patients revealed the presence of close relationships with linear thickness KIM, infectious, immune and metabolic markers, and in patients with atherosclerotic plaques in blood vessels links with indicators of inflammation are additionally found. Using factor analysis latent variables exist revealed, consisting of indices and thickness of the CMM, in group 1 – blood lipids, in the 2nd – infectious factors (CMV, C. pneumoniae and immune parameters. In the 3rd group vascular wall was linked with infectious diseases, immune and inflammatory indices and blood lipids, and systolic and diastolic blood pressure.Conclusion. The closest relationship with vascular wall of the studied parameters was observed in patients with risk factors of cardiovasculardisease, and in the

  4. Antioxidant enzyme activity is associated with blood pressure and carotid intima media thickness in black men and women: The SABPA study.

    Science.gov (United States)

    van Zyl, Caitlynd; Huisman, Hugo W; Mels, Catharina M C

    2016-05-01

    In the urbanized black population of South Africa, oxidative stress may play a crucial role in the development of hypertension. Since oxidative stress may result from impaired antioxidant capacity we aimed to investigate antioxidant enzyme activity as well as its associations with vascular function and structure in a bi-ethnic population. Participants included 409 subjects almost equally stratified by ethnicity and sex. Blood pressure and carotid intima media thickness (cIMT) were measured and glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) enzyme activities were determined. GR activity was significantly higher in black men (7.71 nmol/min/ml vs 2.23 nmol/min/ml) and women (6.46 nmol/min/ml vs 2.86 nmol/min/ml) (p < 0.001) when compared to their white counterparts. In black women, GPx activity was significantly lower (p < 0.001) when compared to white women (31.9 nmol/min/ml vs 37.1 nmol/min/ml). In black men, cIMT was positively and independently associated with GR activity (R(2) = 0.30; β = 0.18; p = 0.048). In black women, systolic blood pressure (R(2) = 0.21; β = -0.24; p = 0.014), diastolic blood pressure (R(2) = 0.11; β = -0.20; p = 0.044) and mean arterial pressure (R(2) = 0.20; β = -0.31; p = 0.002) were inversely associated with GPx activity. No associations were found in the white groups. The positive association between GR activity and cIMT in black men may be the result of a compensatory response to prevent arterial remodelling. The inverse association between GPx activity and blood pressure in black women may indicate a role for decreased GPx activity in hypertension development in this population. PMID:26990726

  5. Association between adjunctive metformin therapy in young type 1 diabetes patients with excess body fat and reduction of carotid intima-media thickness.

    Science.gov (United States)

    Burchardt, Paweł; Zawada, Agnieszka; Kaczmarek, Jolanta; Marcinkaniec, Justyna; Wysocki, Henryk; Wierusz-Wysocka, Bogna; Grzymisławski, Marian; Rzeźniczak, Janusz; Zozulińska-Ziółkiewicz, Dorota; Naskręt, Dariusz

    2016-08-25

    INTRODUCTION    Lipoprotein-associated phospholipase A2 (Lp-PLA2) and cholesteryl ester lipase (CEL) may oxidize low-density lipoproteins (oxLDL). OBJECTIVES    The aim of the study was to determine the influence of metformin on the metabolism of atherogenic lipid fractions in relation to Lp-PLA2 and CEL levels, as well as assess consequent improvement in the intima-media thickness (IMT) of the common carotid artery in young type 1 diabetes patients with excess body fat. PATIENTS AND METHODS    It was an open-label randomized clinical trial that lasted 6 months. It included a total of 84 people with metabolic decompensation (glycated hemoglobin >7.5%, >58.5 mmol/mol) of diabetes. Adjunctive metformin therapy (in addition to insulin) was administered in 42 patients, and the remaining 42 patients received insulin alone. Glycated low-density lipoproteins (LDLs), oxLDL, Lp-PLA2, and CEL were assessed by commercially available enzyme-linked immunosorbent assay kits. Cartoid IMT was measured using the Carotid Analyser for Research tool. Biochemical analyses were performed using routine laboratory techniques. RESULTS    The reduction of mean carotid IMT was observed in young type 1 diabetic adults treated additionally with metformin (0.6 ±0.1 cm vs 0.53 ±0.1 cm; P = 0.002). This effect was probably due to weight reduction (90 ±16 kg vs 87 ±15 kg, P = 0.054) and the decrease in atherogenic glycated LDL levels (1.5 ±0.5 mg/dl vs 1.6 ±1.046 mg/dl, P = 0.006). No such correlations were observed in patients treated with insulin alone. Additionally, in patients receiving metformin, glycated LDL levels were inversely correlated with Lp-PLA2 levels (r = -0.31, P metformin in young type 1 diabetic patients with excess body fat leads to a significant reduction of mean IMT in the common carotid artery. Concentrations of CEL and Lp-PLA2 were significantly increased in both study arms despite improved glucose metabolism. PMID:27578220

  6. The triple line pattern on carotid intima media thickness imaging and its relationship to cardiovascular risk factors in patients on lipid lowering therapy

    Directory of Open Access Journals (Sweden)

    Singh TA

    2014-06-01

    Full Text Available Tania A Singh,1 Todd C Villines,2 Allen J Taylor31Division of Cardiology, Medstar Georgetown University Hospital, 2Walter Reed National Military Medical Center, Bethesda, MD, 3Georgetown University School of Medicine, Washington, DC, USA Background: Carotid intima media thickness (CIMT infrequently identifies a triple line pattern (TLP in the visualization of the internal elastic lamina. We examined the prevalence and predictors of the TLP among a consecutive series of subjects enrolled in a CIMT clinical trial, and also the effects of lipid lowering therapy.Methods: Baseline CIMT studies of subjects with known heart disease, or high risk for heart disease, were evaluated from a single site of the Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis trial (N=120. One sonographer obtained four views of the right and left far wall common CIMT, using a 13 MHz ultrasound probe. Images were blindly reviewed for the presence of the TLP. The TLP was defined as absent (0, possible (1, or definite (2. A composite score from all four views was calculated. A patient was defined as having the TLP if the composite score was ≥4. Univariate predictors of the TLP were explored. Follow-up ultrasounds at 14 months were also reviewed for presence of the TLP.Results: The prevalence of the TLP at baseline was 22.5%. Among cardiovascular risk variables, systolic blood pressure was significantly higher in subjects displaying the TLP (141.3±15.6 mmHg versus 133.1±18.4 mmHg; P=0.036. There were no differences among those with, and without, the TLP, with respect to other cardiovascular risk variables (age, sex, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, glucose, weight, waist girth, tobacco use, medications, quantitative CIMT, or image quality. During ongoing lipid lowering therapy, the prevalence of the TLP increased to 54

  7. Increased carotid intima-media thickness associated with antibody responses to varicella-zoster virus and cytomegalovirus in HIV-infected patients.

    Directory of Open Access Journals (Sweden)

    Mar Masiá

    Full Text Available OBJECTIVE: We investigated the relationship of the Herpesviridiae with inflammation and subclinical atherosclerosis in HIV-infected patients. METHODS: Prospective study including virologically suppressed HIV-infected patients. IgG antibodies against herpesviruses, carotid intima-media thickness (cIMT, endothelial function through flow-mediated dilatation (FMD of the brachial artery, and blood atherosclerosis biomarkers (hsCRP, TNF-α, IL-6, MCP-1, MDA, sCD14, sCD163, VCAM-1, ICAM-1, D-dimer, and PAI-1 were measured. RESULTS: 136 patients with HIV viral load <200 copies/ml were included. 93.4% patients were infected with herpes simplex virus type-1, 55.9% with herpes simplex virus type-2, 97.1% with varicella-zoster virus, 65.4% with human herpesvirus-6, 91.2% with cytomegalovirus, and 99.3% with Epstein-Barr virus. Previous AIDS diagnosis was associated with higher cytomegalovirus IgG titers (23,000 vs 17,000 AU, P = 0.011 and higher varicella-zoster virus IgG titers (3.19 vs 2.88 AU, P = 0.047, and there was a positive correlation of the Framingham risk score with IgG levels against cytomegalovirus (Spearman's Rho 0.216, P = 0.016 and Herpes simplex virus-2 (Spearman's Rho 0.293, P = 0.001. IgG antibodies against cytomegalovirus correlated in adjusted analysis with the cIMT (P = 0.030. High seropositivity for varicella-zoster virus (OR 2.91, 95% CI 1.05-8.01, P = 0.039, and for cytomegalovirus (OR 3.79, 95% CI 1.20-11.97, P = 0.023 were predictors for the highest quartile of the cIMT in adjusted analyses. PAI-1 levels were independently associated with cytomegalovirus IgG titers (P = 0.041, IL-6 and ICAM-1 levels with varicella-zoster virus IgG (P = 0.046 and P = 0.035 respectively, and hsCRP levels with Herpes simplex virus-2 IgG (P = 0.035. CONCLUSION: In virologically suppressed HIV-infected patients, antibody responses against herpesviruses are associated with subclinical atherosclerosis, and with increased inflammation and coagulation

  8. 心脏瓣膜钙化与颈动脉内膜中层厚度的相关性研究%Relationship of Heart Valve Calcification and Carotid Intima Media Thickness

    Institute of Scientific and Technical Information of China (English)

    贾彦青; 党群; 姚民强; 李永健

    2012-01-01

    目的:研究心脏瓣膜钙化程度与颈动脉内膜中层厚度、斑块积分的相关性.方法:用经胸多普勒超声显像仪评估426例患者心脏瓣膜钙化情况,根据瓣膜钙化诊断标准将所有患者分为无钙化组、轻度钙化组、中度钙化组和重度钙化组.比较4组间的一般资料、病史、血压、血脂,同时测量4组患者颈动脉内膜中层厚度、软斑块积分、硬斑块积分及总斑块积分.结果:4组间的年龄、性别、体质量指数、吸烟情况、总胆固醇、三酰甘油、高密度脂蛋白胆固醇,低密度脂蛋白胆固醇差异无统计学意义;瓣膜钙化程度与冠心病患病率、收缩压、脉压、颈动脉内膜中层厚度、总斑块积分、硬斑块积分呈正相关(r.分别为0.546、0.628、0.512、0.802、0.628、0.544,均P<0.001),与舒张压、软斑块积分无相关性.结论:心脏瓣膜钙化程度可作为推测颈动脉内膜中层厚度、总斑块积分、硬斑块积分的一个重要指标.%Objective:To investigate the relationship between the degree of heart valve calcification and carotid intima media thickness and plaque integral. Methods: The valve calcification was assessed using transthoracic Doppler ultrasound imaging in 426 patients. All patients were divided into four groups according to the diagnostic criteria, including no calcification group, mild calcification group, moderate and severe calcification group. The general information, medical history, blood pressure, blood lipids were compared between four groups. The intima media thickness, suft plaque score, hard plaque score and the total plaque score of carotid artery were also measured in patients of four groups. Results: There were no significant differences in age, gender, body mass index, smoking status, total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein between four groups. The degree of valve calcification was positively correlated with

  9. Diminished heart rate reactivity to acute psychological stress is associated with enhanced carotid intima-media thickness through adverse health behaviors.

    Science.gov (United States)

    Ginty, Annie T; Williams, Sarah E; Jones, Alexander; Roseboom, Tessa J; Phillips, Anna C; Painter, Rebecca C; Carroll, Douglas; de Rooij, Susanne R

    2016-06-01

    Recent evidence demonstrates that individuals with low heart rate (HR) reactions to acute psychological stress are more likely to be obese or smokers. Smoking and obesity are established risk factors for increased carotid intima-media thickness (IMT). The aim of this study was to examine the potential pathways linking intima-media thickness, smoking, body mass index (BMI), and HR stress reactivity. A total of 552 participants, 47.6% male, M (SD) age = 58.3 (0.94) years, were exposed to three psychological stress tasks (Stroop, mirror drawing, and speech) preceded by a resting baseline period; HR was recorded throughout. HR reactivity was calculated as the average response across the three tasks minus average baseline HR. Smoking status, BMI, and IMT were determined by trained personnel. Controlling for important covariates (e.g., socioeconomic status), structural equation modeling revealed that BMI and smoking mediated the negative relationship between HR reactivity and IMT. The hypothesized model demonstrated a good overall fit to the data, χ(2) (8) = 0.692, p = .403; CFI = 1.00; TLI = 1.00 SRMR = .01; RMSEA < .001 (90% CI < 0.01-0.11). HR reactivity was negatively related to BMI (β = -.16) and smoking (β = -.18), and these in turn were positively associated with IMT (BMI: β = .10; smoking: β = .17). Diminished HR stress reactivity appears to be a marker for enlarged IMT and appears to be exerting its impact through already established risks. Future research should examine this relationship longitudinally and aim to intervene early. PMID:27005834

  10. Effect of Short term intensive multitherapy on Carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    GUO Li-xin; PAN Qi; WANG Xiao-xia; LI Hui; ZHANG Li-na; CHI Jia-min; WANG Yao

    2008-01-01

    Background Controlling plasma glucose levels, blood pressure and lipid levels is proven to reduce the risk of vascular complications in patients with type 2 diabetes mellitus. This has prompted intensive multitherapy targeted at several macrovascular risk factors.Carotid intima-media thickness(cIMT)is a reliable measure of early atherosclerosis. We sought to determine whether a 6-month intensive mutiltherapy program resulted in better goal attainment than usual care and its effect on the development of cIMT among patients with newly diagnosed type 2 diabetes mellitus. Methods The study randomly assigned 220 patients with newly diagnosed type 2 diabetes mellitus to intensive or traditional therapy groups. The clinical parameters, such as fasting plasma glucose, total cholesterol, triglyceride, blood pressure, body weight and insulin were assessed at the baseline and after the 6-month therapy. cIMT of the patients wasalso obtained. Results The average levels of fasting plasma glucose, hemoglobin A1c, total cholesterol (TC)and low-density lipoprotein cholesterol (LDL-C)in the intensive group were significantly lower than those in the control group at the end of 6-month treatment. By 6 months, a higher proportion of patients in the intensive therapy group than in the control group attained goals for fasting plasma glucose(FPG), TC, LDL-C and hemoglobin A1c.With intensive multherapy the level of carotid intima-media thickness in the intensive therapy group was lower than that in the control group((0.88±0.26)mm vs(0.96±0.22)mm, P<0.01).Conclusions The evidence from this clinical trial demonstrates that intensive glucose. lipid and blood pressure control in patients with newly diagnosed type 2 diabetes is associated with diabetic macrovascular benefits. Intensive multitherapy allows more patients to achieve aims of control and may reduce macrovascular complications and delay disease progression.

  11. Alterations in adhesion molecules, pro-inflammatory cytokines and cell-derived microparticles contribute to intima-media thickness and symptoms in postmenopausal women.

    Directory of Open Access Journals (Sweden)

    Nicté Figueroa-Vega

    Full Text Available Menopause, the cessation of menses, occurs with estrogens decline, low-grade inflammation, and impaired endothelial function, contributing to atherosclerotic risk. Intima-media thickness (IMT is an early subclinical biomarker of atherosclerosis. Inflammation may have a role on symptoms: hot flashes, anxiety, and depressive mood, which also are related to endothelial dysfunction, increased IMT and cardiovascular risk. In this study we compared several inflammatory markers in early vs. late postmenopausal women and studied the association of IMT and symptoms with these markers in the full sample. In a cross-sectional design including 60 women (53.1 ± 4.4 years old at early and late postmenopause, we evaluated the expression of CD62L, ICAM-1, PSGL-1, CD11b, CD11c, and IL-8R on PBMC by flow cytometry. Serum soluble ICAM-1, sVCAM-1, sCD62E, sCD62P, CXCL8, IL-1β, IL-6, and TNF-α levels were quantified by ELISA. Plasma levels of microparticles (MPs were determined by FACS. Finally, carotid intima-media thickness (IMT was measured by ultrasound. We observed that ICAM-1 expression by lymphocytes and serum sVCAM-1 levels were augmented at late postmenopause. Late postmenopause women with severe hot flashes had increased expression of CD62L and IL-8R on neutrophils. By multivariate analysis, the carotid IMT was strongly associated with membrane-bound TNF-α, CD11b expression, Annexin V(+ CD3(+ MPs, LPS-induced NO production, HDL-cholesterol and age. Depressive mood was associated negatively with PSGL-1 and positively with LPS-induced NO. Finally, Log(AMH levels were associated with carotid IMT, IL-8R expression and time since menopause. IMT and depressive mood were the main clinical features related to vascular inflammation. Aging, hormonal changes and obesity were also related to endothelial dysfunction. These findings provide further evidence for a link between estrogen deficiency and low-grade inflammation in endothelial impairment in mature women.

  12. Oxidized LDL and C-reactive protein level in relation to carotid intima-media thickness in population with risk factors for atherosclerosis

    Directory of Open Access Journals (Sweden)

    Čaparević Zorica

    2009-01-01

    Full Text Available Introduction. Elevated levels of oxidized LDL cholesterol (OxLDL are considered to be a key factor of initiating and accelerating atherosclerosis. It promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the formation of macrophage foam cells. Objective. To determine the relationship among OxLDL, C-reactive protein (CRP level and carotid intima-media thickness (IMT in population with risk factors for atherosclerosis. Methods. The study group consisted of 125 clinically healthy, hypercholesterolaemic subjects (49.3±5.7 years; 75 females and 50 males compared with 100 age-matched population-based control subjects. The study group was divided into two subgroups: subgroup A (the levels of LDL cholesterol > 5 mmol/L and subgroup B (the levels of LDL cholesterol <5 mmol/L. None of the subjects had history of cerebrovascular, ischaemic heart disease, hypertension or diabetes mellitus. Lipid profiles were measured by enzymatic methods. OxLDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminescent methods (Immulite - DPC. The common carotid IMT was measured by the B-mode ultrasound. Results Compared to controls, the study group had higher levels of OxLDL (119.97±43.15 vs. 82.03±25.99 IU/L; p<0.01 and CRP (6.20±3.55 vs. 2.68±3.04 mg/ml; p<0.05. IMT was significantly higher in study subjects (1.14±0.38 vs. 0.72±0.24 mm; p<0.05. We also found that, in the whole study group, IMT significantly positively correlated with OxLDL (r=0.442; p<0.05. We found that in the study subgroup A, IMT positively correlated with CRP (r=0.792; p<0.01. In controls, we found a significantly positive association between IMT and OxLDL (r=0.781; p<0.01 and CRP (r=0.748; p<0.01. Conclusion. The elevated levels of OxLDL and CRP are associated with higher common carotid intima-media thickness in population with risk factors for atherosclerosis.

  13. 天津市公安民警颈动脉内中膜厚度与代谢综合征的关系%Correlation of carotid intima-media thickness and metabolic syndrome in Tianjin city policemen

    Institute of Scientific and Technical Information of China (English)

    刘雯; 刘轩; 岳松

    2015-01-01

    compared between two groups. The lo⁃gistic regression model was used to analyse the influencing factors of carotid artery intima-media thickness. Results CIMT and CIMT incrassation ratio (communis, internal and external carotid) were significantly higher in MS group than those of control group (P<0.01). The risk factors for CIMT included family history of hypertension, chronic stress, smoking, family history of diabetes, high fat diet and high homocysteine levels, and dairy products were protective factors for CIMT incrassa⁃tion. Conclusion The reason of carotid artery intima-media thickness is diversity. The healthy lifestyle and clinical inter⁃vention to retard CIMT are advocate, which are conducive to the control of atherosclerosis.

  14. Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity

    Directory of Open Access Journals (Sweden)

    Paccaud Fred

    2007-10-01

    Full Text Available Abstract Background Impaired glucose regulation (IGR is associated with detrimental cardiovascular outcomes such as cardiovascular disease risk factors (CVD risk factors or intima-media thickness (IMT. Our aim was to examine whether these associations are mediated by body mass index (BMI, waist circumference (waist or fasting serum insulin (insulin in a population in the African region. Methods Major CVD risk factors (systolic blood pressure, smoking, LDL-cholesterol, HDL-cholesterol, were measured in a random sample of adults aged 25–64 in the Seychelles (n = 1255, participation rate: 80.2%. According to the criteria of the American Diabetes Association, IGR was divided in four ordered categories: 1 normal fasting glucose (NFG, 2 impaired fasting glucose (IFG and normal glucose tolerance (IFG/NGT, 3 IFG and impaired glucose tolerance (IFG/IGT, and 4 diabetes mellitus (DM. Carotid and femoral IMT was assessed by ultrasound (n = 496. Results Age-adjusted levels of the major CVD risk factors worsened gradually across IGR categories (NFG Conclusion We found graded relationships between IGR categories and both major CVD risk factors and carotid/femoral IMT. These relationships were only partly accounted for by BMI, waist and insulin. This suggests that increased CVD-risk associated with IGR is also mediated by factors other than the considered markers of adiposity and insulin resistance. The results also imply that IGR and associated major CVD risk factors should be systematically screened and appropriately managed.

  15. The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD.

    Science.gov (United States)

    Asemi, Zatollah; Raygan, Fariba; Bahmani, Fereshteh; Rezavandi, Zohreh; Talari, Hamid Reza; Rafiee, Motahereh; Poladchang, Somayyeh; Darooghegi Mofrad, Manijeh; Taheri, Sara; Mohammadi, Ali Akbar; Esmaillzadeh, Ahmad

    2016-07-01

    This study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5µg vitamin D, 90 µg vitamin K plus 500 mg Ca supplements (n 33) or placebo (n 33) twice a day for 12 weeks. Fasting blood samples were obtained at the beginning of the study and after the 12-week intervention period to determine related markers. Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (-0·04 (sd 0·22) v. +0·04 (sd 0·09) mm, P=0·02). Changes in serum vitamin D (+6·5 (sd 7·8) v. +0·4 (sd 2·2) ng/ml, Pvitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status. The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding.

  16. Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    Lundby-Christensen, Louise; Vaag, Allan; Tarnow, Lise;

    2016-01-01

    OBJECTIVE: To assess the effect of 3 insulin analogue regimens on change in carotid intima-media thickness (IMT) in patients with type 2 diabetes. DESIGN AND SETTING: Investigator-initiated, randomised, placebo-controlled trial with a 2×3 factorial design, conducted at 8 hospitals in Denmark....... PARTICIPANTS AND INTERVENTIONS: Participants with type 2 diabetes (glycated haemoglobin (HbA1c)≥7.5% (≥58 mmol/mol), body mass index >25 kg/m(2)) were, in addition to metformin versus placebo, randomised to 18 months open-label biphasic insulin aspart 1-3 times daily (n=137) versus insulin aspart 3 times daily...... adverse events were other prespecified outcomes. RESULTS: Carotid IMT change did not differ between groups (biphasic -0.009 mm (95% CI -0.022 to 0.004), aspart+detemir 0.000 mm (95% CI -0.013 to 0.013), detemir -0.012 mm (95% CI -0.025 to 0.000)). HbA1c was more reduced with biphasic (-1.0% (95% CI -1.2...

  17. Infant adiposity at birth and early postnatal weight gain predict increased aortic intima-media thickness at 6 weeks of age: a population-derived cohort study.

    Science.gov (United States)

    McCloskey, Kate; Burgner, David; Carlin, John B; Skilton, Michael R; Cheung, Michael; Dwyer, Terence; Vuillermin, Peter; Ponsonby, Anne-Louise

    2016-03-01

    Infant body composition and postnatal weight gain have been implicated in the development of adult obesity and cardiovascular disease, but there are limited prospective data regarding the association between infant adiposity, postnatal growth and early cardiovascular parameters. Increased aortic intima-media thickness (aortic IMT) is an intermediate phenotype of early atherosclerosis. The aim of the present study was to investigate the relationship between weight and adiposity at birth, postnatal growth and aortic IMT. The Barwon Infant Study (n=1074 mother-infant pairs) is a population-derived birth cohort. Infant weight and other anthropometry were measured at birth and 6 weeks of age. Aortic IMT was measured by trans-abdominal ultrasound at 6 weeks of age (n=835). After adjustment for aortic size and other factors, markers of adiposity including increased birth weight (β=19.9 μm/kg, 95%CI 11.1, 28.6; Pinfant weight and adiposity at birth, as well as increased early weight gain, were positively associated with aortic IMT. Excessive accumulation of adiposity during gestation and early infancy may have adverse effects on cardiovascular risk.

  18. Kallistatin as a marker of microvascular complications in children and adolescents with type 1 diabetes mellitus: Relation to carotid intima media thickness.

    Science.gov (United States)

    El-Asrar, Mohamed A; Andrawes, Nevine G; Ismail, Eman A; Salem, Shaimaa Mh

    2015-12-01

    In diabetes, angiogenesis is disturbed, contributing to proliferative retinopathy, nephropathy and neuropathy. Kallistatin, a serine proteinase inhibitor, has anti-angiogenic effects. We assessed serum kallistatin in children and adolescents with type 1 diabetes as a potential marker for microvascular complications and its relation to carotid intima media thickness (CIMT). Sixty patients with type 1 diabetes were divided into two groups according to the presence of microvascular complications and compared with 30 healthy controls. High-sensitivity C-reactive protein (hs-CRP), HbA1c, urinary albumin creatinine ratio (UACR), kallistatin levels and CIMT were assessed. Kallistatin levels were significantly higher in patients with microvascular complications (9.9 ± 2.38 ng/mL) and those without complications (5.0 ± 1.5 ng/mL) than in healthy controls (1.39 ± 0.55 ng/mL; pgroup (pblood glucose, HbA1c, triglycerides, total cholesterol, hs-CRP, UACR and CIMT (pdiabetes and its relation with CIMT may reflect vascular dysfunction and suggest a link between micro- and macro-angiopathy.

  19. The association of carotid intima media thickness with retinol binding protein-4 and total and high molecular weight adiponectin in type 2 diabetic patients

    Directory of Open Access Journals (Sweden)

    Mansouri Masoumeh

    2012-08-01

    Full Text Available Abstract Background The aim of this study was to investigate whether carotid intima media thickness (CIMT is associated with serum level of retinol- binding protein-4 (RBP4 and total and high molecular weight (HMW adiponectin in type 2 diabetes (T2DM without clinical symptom of atherosclerotic disease. Method 101 type 2 diabetic patients (mean age, 53.63 ± 8.42 years and 42 body mass index (BMI matched control (mean age 50.1 ± 8.4 were recruited. The CIMT was assessed by using B-mode ultrasonography, while serum levels of RBP4 and total and HMW adiponectin were measured by using enzyme linked immunosorbant assay (ELISA. Linear regression analysis was performed with CIMT as dependent variable and adipokines and cardio metabolic risk factors as independent variables. Result The CIMT was higher in diabetic group compared to control group (p Age (B = 0.44 P Conclusion In conclusion, the present study showed that serum levels of RBP4 or total and HMW adiponectin were not potential predictors of CIMT in type 2 diabetic patients who exposed to this risk factor at least for nine years.

  20. The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes

    OpenAIRE

    Ekaterina Vladimirovna Ivannikova; Victor Yurievich Kalashnikov; Olga Mikhaylovna Smirnova; Alexander Borisovich Kuznetsov; Sergei Anatolievich Terekhin; Alexander Viktorovich Il'in

    2014-01-01

    ObjectiveTo determine the levels of fibroblast transforming growth factor (TGFβ1), basic fibroblast growth factor (β-FGF), markers of nonspecific inflammatory response (interleukin-6 (IL-6)), C-reactive protein (CRP), advanced glycation end-products (AGEs) and their receptors (RAGEs) and to study their effect on the intima-media complex (IMC) thickness in patients with coronary heart disease (CHD) and type 2 diabetes, depending on carbohydrate metabolism compensation.Materials and Methods37 p...

  1. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh

    Science.gov (United States)

    Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G.; Liu, Mengling; Cheng, Xin; Parvez, Faruque; Paul-Brutus, Rachelle; Islam, Tariqul; Paul, Rina Rani; Sarwar, Golam; Ahmed, Alauddin; Jiang, Jieying; Islam, Tariqul; Slavkovich, Vesna; Rundek, Tatjana; Demmer, Ryan T.; Desvarieux, Moise; Ahsan, Habibul; Chen, Yu

    2014-01-01

    Epidemiologic studies that evaluated genetic susceptibility to the effects of arsenic exposure from drinking water on subclinical atherosclerosis are limited. We conducted a cross-sectional study of 1,078 participants randomly selected from the Health Effects of Arsenic Longitudinal Study in Bangladesh to evaluate whether the association between arsenic exposure and carotid artery intima-medial thickness (cIMT) differs by 207 single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction. Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT. For instance, the joint presence of a higher level of well-water arsenic (≥ 40.4 μg/L) and the GG genotype of AS3MT rs3740392 was associated with a difference of 40.9 μm (95% CI = 14.4, 67.5) in cIMT, much greater than the difference of cIMT associated with the genotype alone (β = -5.1 μm, 95% CI = -31.6, 21.3) or arsenic exposure alone (β = 7.2 μm, 95% CI = -3.1, 17.5). The pattern and magnitude of the interactions were similar when urinary arsenic was used as the exposure variable. Additionally, the at-risk genotypes of the AS3MT SNPs were positively related to proportion of monomethylarsonic acid (MMA) in urine, which is indicative of arsenic methylation capacity. The findings provide novel evidence that genetic variants related to arsenic metabolism may play an important role in arsenic-induced subclinical atherosclerosis. Future replication studies in diverse populations are needed to confirm the findings. PMID:24593923

  2. Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Raquel López-Mejías

    2014-01-01

    Full Text Available Introduction. Rheumatoid arthritis (RA is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT and presence/absence of carotid plaques and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.

  3. Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Deborah F van Breukelen-van der Stoep

    Full Text Available Rheumatoid arthritis (RA has been identified as an independent cardiovascular risk factor. The importance of risk factors such as hypertension and hyperlipidemia in the generation of atherosclerosis in RA patients is unclear. This study analyzed clinical parameters associated with carotid intima media thickness (cIMT in patients with RA.Subjects with RA and healthy controls without RA, both without known cardiovascular disease, were included. Participants underwent a standard physical examination and laboratory measurements including a lipid profile. cIMT was measured semi-automatically by ultrasound.In total 243 RA patients and 117 controls were included. The median RA disease duration was 7 years (IQR 2-14 years. The median DAS28 was 2.4 (IQR 1.6-3.2 and 114 (50.4% of the RA patients were in remission. The presence of RA and cIMT were not associated (univariate analysis. Multivariable regression analysis showed that cIMT in RA patients was associated with age (B = 0.006, P<0.001 and systolic blood pressure (B = 0.003, P = 0.003. In controls, cIMT was associated with age (B = 0.006, P<0.001 and smoking (B = 0.097, P = 0.001.cIMT values were similar between RA patients and controls. Hypertension was strongly associated with cIMT in RA patients. After adjustment, no association between cIMT and specific RA disease characteristics was found in this well treated RA cohort.

  4. Previous gestational diabetes is independently associated with increased carotid intima-media thickness, similarly to metabolic syndrome – a case control study

    Directory of Open Access Journals (Sweden)

    Freire Claudia Maria

    2012-05-01

    Full Text Available Abstract Background Women with previous gestational diabetes mellitus (pGDM face a higher risk of developing type 2 diabetes and, consequently, a higher cardiovascular risk. This study aimed to compare the carotid intima-media thickness (cIMT from young women with pGDM to those with metabolic syndrome (MS and to healthy controls (CG to verify whether a past history of pGDM could be independently associated with increased cIMT. Methods This is a cross-sectional study performed in two academic referral centers. Seventy-nine women with pGDM, 30 women with MS, and 60 CG aged between 18 and 47 years were enrolled. They all underwent physical examination and had blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc, and triglycerides determined. The cIMT was measured by ultrasound in several carotid segments. The primary endpoint was cIMT and clinically relevant parameters included as predictors were: age, systolic blood pressure, waist, BMI, total cholesterol, LDLc, triglycerides, fasting glucose, previous history of GDM as a whole group, previous history of GDM without MS, presence of DM, presence of MS, and parity. Results cIMT was significantly higher in pGDM when compared to CG in all sites of measurements (P  0.05 and an increased cIMT when compared to controls (P  Conclusions Previous GDM was independently associated with increased composite cIMT in this young population, similarly to those with MS and regardless the presence of established cardiovascular risk factors.

  5. An investigation of two-dimensional ultrasound carotid plaque presence and intima media thickness in middle-aged South Asian and European men living in the United kingdom.

    Directory of Open Access Journals (Sweden)

    Nazim Ghouri

    Full Text Available Ultrasound studies of carotid intima media thickness (cIMT and plaques are limited in South Asians, a group at elevated cardiovascular disease (CVD risk. We determined whether South Asians have a difference in these ultrasound markers compared to Europeans living in the United Kingdom and whether measured risk factor(s could account for any such differences.One hundred South Asian men, aged 40 to 70 years and 100 European men of similar age and BMI, without diagnosed CVD or diabetes, underwent carotid ultrasound for measurement of cIMT and carotid plaque presence. Physical activity, cardiorespiratory fitness, anthropometry and blood pressure were assessed, fasted blood taken for measurement of cardiometabolic risk factors and demographic and lifestyle factors recorded.Age-adjusted mean (SD cIMT was similar in South Asians and Europeans (0.64 (0.16 mm v 0.65 (0.12 mm, p = 0.64. Plaque was present in 48 South Asians and 37 Europeans and overall, there was no age-adjusted difference between South Asian and Europeans for plaque score(odds ratio 1.49, 95% CI, 0.86-2.80, p = 0.16, however, South Asians appeared to have more plaques at a younger age than Europeans; at age 40-50 years the odds of South Asians having plaques was 2.63 (95% CI, 1.16-5.93 times that for Europeans.cIMT is similar between healthy South Asian and European men. Whilst there was no overall difference in plaque presence in South Asians, there is an indication of greater plaque prevalence at younger ages--an observation requiring further investigation. Prospective studies linking plaques to CVD outcomes in South Asians are needed to investigate whether these measures help improve CVD risk prediction.

  6. Both serum apolipoprotein B and the apolipoprotein B/apolipoprotein A-I ratio are associated with carotid intima-media thickness.

    Directory of Open Access Journals (Sweden)

    Fei Huang

    Full Text Available BACKGROUND: Previous studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT were less explored. METHODOLOGY AND PRINCIPAL FINDINGS: The cross-sectional study included 6069 participants aged 40 years or older with NGT from Shanghai, China. Serum fasting traditional lipids (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C] and triglycerides [TG], apoA-I and apoB were assessed. A high-resolution B-mode ultrasonography was performed to measure CIMT. We found CIMT increased progressively across the quartiles of serum apoB (p for trend <0.0001. In logistic regression, concentrations of apoB (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.18-1.36, TC (OR 1.23, 95% CI 1.14-1.32, LDL-C (OR 1.25, 95% CI 1.16-1.34 and TG (OR 1.11, 95% CI 1.04-1.20 were significantly related to elevated CIMT after adjusted for age and sex. Meanwhile, the apoB/apoA-I ratio (OR 1.25, 95% CI 1.17-1.34 related to elevated CIMT. ApoB (OR 1.23, 95% CI 1.00-1.51 and the apoB/apoA-I ratio (OR 1.19, 95% CI 1.04-1.36 remained significantly associated with elevated CIMT, after adjusted for the traditional CVD risk factors including traditional lipids. CONCLUSIONS AND SIGNIFICANCE: There were significant associations between serum apoB, the apoB/apoA-I ratio and elevated CIMT. Serum apoB and the apoB/apoA-I ratio might be independent predictors of early atherosclerosis in NGT.

  7. The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD.

    Science.gov (United States)

    Asemi, Zatollah; Raygan, Fariba; Bahmani, Fereshteh; Rezavandi, Zohreh; Talari, Hamid Reza; Rafiee, Motahereh; Poladchang, Somayyeh; Darooghegi Mofrad, Manijeh; Taheri, Sara; Mohammadi, Ali Akbar; Esmaillzadeh, Ahmad

    2016-07-01

    This study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5µg vitamin D, 90 µg vitamin K plus 500 mg Ca supplements (n 33) or placebo (n 33) twice a day for 12 weeks. Fasting blood samples were obtained at the beginning of the study and after the 12-week intervention period to determine related markers. Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (-0·04 (sd 0·22) v. +0·04 (sd 0·09) mm, P=0·02). Changes in serum vitamin D (+6·5 (sd 7·8) v. +0·4 (sd 2·2) ng/ml, Png/ml, P=0·03) and plasma malondialdehyde concentrations (-0·4 (sd 0·5) v. -1·0 (sd 1·1) µmol/l, P=0·007) compared with placebo. Overall, vitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status. The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding. PMID:27198036

  8. The Value of Measurement of Carotid Intima-media Thickness Using Ultrasound in Patients with Cardio-cerebro-vascular Diseases%超声检测颈动脉内中膜厚度在心脑血管疾病中的价值

    Institute of Scientific and Technical Information of China (English)

    刘志敏; 黄碧霞; 古泉辉

    2013-01-01

    Objective:To study the value of measurement of carotid intima-media thickness using ultrasound in cardio-cerebro-vascular diseases. Method:Patients associated with hypertension,diabetes,coronary heart disease,cerebral infarction from our hospital from August 2012 to April 2013 were recruited.Color Doppler ultrasound was used to measure their carotid intima-media thickness(IMT) as well as artery atheromatous plague and stenosis of carotid artery.Result:(1)An average of 58%of patients indicated having abnormities of carotid intima media thickness when 52%and 9%of them having carotid artery atheromatous plague and stenosis of carotid artery respectively.(2)Patients with anomaly of carotid intima media thickness had significantly higher rates of hypertension and cerebral infarction.Conclusion:Noninvasive measurement of carotid intima-media thickness using Color Doppler ultrasound is a effective and convenient technique of screening and assessment for atherosclerosis among patients.It will be helpful for cohort at high risk of atherosclerosis and for diagnosis and treatment of this disease.%目的:探讨超声测量颈总动脉内-中膜厚度(IMT)在心脑血管疾病中的价值。方法:2012年8月-2013年4月来笔者所在医院就诊的高血压、糖尿病、冠心病、脑梗死患者均经高分辨率彩色多普勒超声检测双侧颈动脉内中膜厚度(IMT)、斑块有无及性质、管腔狭窄程度。结果:(1)颈动脉IMT异常者占58%,颈动脉斑块阳性者占52%,颈动脉狭窄者占9%,以轻度狭窄为主。(2)颈动脉内中膜检测有阳性的病变者中,高血压与脑梗死患者的检出率较高。结论:采用高分辨率彩色多普勒超声检测颈动脉内中膜厚度的方法,对筛查和评估动脉粥样硬化疾病,是一种简便、经济、有效、无创、可测量、重复性好的科学手段;也可以对无临床症状的高危人群的预后提供帮助;为早期临床诊断及干预动脉硬化提供依据。

  9. Carotid Intima-media Thickness Measurements: Relations with Atherosclerosis, Risk of Cardiovascular Disease and Application in Randomized Controlled Trials.

    Science.gov (United States)

    Bots, Michiel L; Evans, Gregory W; Tegeler, Charles H; Meijer, Rudy

    2016-01-20

    Advances in the field of carotid ultrasound have been incremental, resulting in a steady decrease in measurement variability. Improvements in edge detection algorithms point toward increasing automation of CIMT measurements. The major advantage of CIMT is that it is completely noninvasive and can be repeated as often as required. It provides a continuous measure since all subjects have a measurable carotid wall. It is also relatively inexpensive to perform, and the technology is widely available. A graded relation between raising LDL cholesterol and increased CIMT is apparent. Increased CIMT has been shown consistently to relate the atherosclerotic abnormalities elsewhere in the arterial system. Moreover, increased CIMT predicts future vascular events in both populations from Caucasian ancestry and those from Asian ancestry. Furthermore, lipid‑lowering therapy has been shown to affect CIMT progression within 12–18 months in properly designed trials with results congruent with clinical events trials. In conclusion, when one wants to evaluate the effect of a pharmaceutical intervention that is to be expected to beneficially affect atherosclerosis progression and to reduce CV event risk, the use of CIMT measurements over time is a valid, suitable, and evidence‑based choice. PMID:26830994

  10. Carotid Intima-media Thickness Measurements: Relations with Atherosclerosis, Risk of Cardiovascular Disease and Application in Randomized Controlled Trials.

    Science.gov (United States)

    Bots, Michiel L; Evans, Gregory W; Tegeler, Charles H; Meijer, Rudy

    2016-01-20

    Advances in the field of carotid ultrasound have been incremental, resulting in a steady decrease in measurement variability. Improvements in edge detection algorithms point toward increasing automation of CIMT measurements. The major advantage of CIMT is that it is completely noninvasive and can be repeated as often as required. It provides a continuous measure since all subjects have a measurable carotid wall. It is also relatively inexpensive to perform, and the technology is widely available. A graded relation between raising LDL cholesterol and increased CIMT is apparent. Increased CIMT has been shown consistently to relate the atherosclerotic abnormalities elsewhere in the arterial system. Moreover, increased CIMT predicts future vascular events in both populations from Caucasian ancestry and those from Asian ancestry. Furthermore, lipid‑lowering therapy has been shown to affect CIMT progression within 12–18 months in properly designed trials with results congruent with clinical events trials. In conclusion, when one wants to evaluate the effect of a pharmaceutical intervention that is to be expected to beneficially affect atherosclerosis progression and to reduce CV event risk, the use of CIMT measurements over time is a valid, suitable, and evidence‑based choice.

  11. The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Ekaterina Vladimirovna Ivannikova

    2014-05-01

    Full Text Available ObjectiveTo determine the levels of fibroblast transforming growth factor (TGFβ1, basic fibroblast growth factor (β-FGF, markers of nonspecific inflammatory response (interleukin-6 (IL-6, C-reactive protein (CRP, advanced glycation end-products (AGEs and their receptors (RAGEs and to study their effect on the intima-media complex (IMC thickness in patients with coronary heart disease (CHD and type 2 diabetes, depending on carbohydrate metabolism compensation.Materials and Methods37 patients with CHD underwent a general clinical examination, analysis of the carbohydrate and lipid metabolism parameters and the renal function, and also were evaluated with instrumental methods of analysis (echocardiography, coronary angiography and duplex scanning of the brachiocephalic arteries. To determine the level of the analyzed parameters, blood samples were taken from the aorta during coronary angiography and concomitantly from the cubital vein in all patients.ResultsThe presence of diabetes mellitus (DM in patients with CHD was found to be associated with a more severe atherosclerotic disease of the coronary and brachiocephalic vessels. A direct correlation between the degree of stenosis and the level of fibroblast growth factors, inflammatory factors, and advanced glycation end-products was found. A direct correlation between AGE and TGFβ1 and the lipid metabolism parameters was established. A statistically significant elevation of the studied parameters in the arterial and venous blood of patients with DM was revealed.ConclusionThese findings confirm the relationship between connective tissue disorders and lipid metabolism in the pathogenesis of atherosclerosis. A negative effect of hyperglycaemia on atherosclerotic changes of the vascular wall was demonstrated.

  12. Comparison of Carotid Intima-Media Thickness in Pediatric Patients with Metabolic Syndrome, Heterozygous Familial Hyperlipidemia and Normals

    Directory of Open Access Journals (Sweden)

    Arvind Vijayasarathi

    2014-01-01

    Full Text Available Background. Our goal was to compare the carotid intimal-medial thickness (CIMT of untreated pediatric patients with metabolic syndrome (MS, heterozygous familial hyperlipidemia (heFH, and MS+heFH against one another and against a control group consisting of healthy, normal body habitus children. Methods. Our population consisted of untreated pediatric patients (ages 5–20 yrs who had CIMT measured in a standardized manner. Results. Our population included 57 with MS, 23 with heFH, and 10 with MS+heFH. The control group consisted of 84 children of the same age range. Mean CIMT for the MS group was 469.8 μm (SD = 67, 443.8 μm (SD = 61 for the heFH group, 478.3 μm (SD = 70 for the MS+heFH group, and 423.2 μm (SD = 45 for the normal control group. Significance differences between groups occurred for heFH versus MS (P=0.022, heFH versus control (P=0.038, MS versus control (P=9.0E-10, and MS+heFH versus control (P=0.003. Analysis showed significant negative correlation between HDL and CIMT (r=-0.32,  P=0.03 but not for LDL, triglycerides, BP, waist circumference, or BMI. Conclusion. For pediatric patients, the thickest CIMT occurred for patients with MS alone or for those with MS+heFH. This indicates that MS, rather than just elevated LDL, accounts for more rapid thickening of CIMT in this population.

  13. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study

    Science.gov (United States)

    Grinsztejn, Beatriz; da Fonseca, Maria de Jesus M.; Griep, Rosane Härter; Lotufo, Paulo; Bensenor, Isabela; Mill, José G.; Moreira, Rodrigo de C.; Moreira, Ronaldo I.; Friedman, Ruth K.; Santini-Oliveira, Marilia; Cardoso, Sandra W.; Veloso, Valdiléa G.; Chor, Dóra

    2016-01-01

    Background Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. Methods We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls–FCs); and 10,943 participants of the ELSA-Brasil study. Linear regression models were used to study associations of the 3 groups and several covariables with cIMT. Propensity scores weighting (PSW) were also employed to balance data. Results Median thickness in mm (IQR) were 0.54 (0.49,0.62); 0.58 (0.52,0.68); and 0.57 (0.49,0.70), HIV, FCs and ELSA-Brasil groups, respectively (p-value<0.001). The best linear model chosen did not include the group variables, after adjusting for all the variables chosen, showing no difference of cIMT across groups. Similar results were obtained with PSW. Several traditional CVD risk factors were also significantly associated with cIMT: female gender, higher education and higher HDL were negatively associated while risk factors were older age, current/former smoker, AMI/stroke family history, CVD history, hypertension, DM, higher BMI and total cholesterol. Conclusions We show for the first time in a middle-income setting that cIMT, is not different in HIV-infected patients in Rio de Janeiro compared with 2 different groups of non-HIV-infected individuals. Traditional CVD risk factors are associated with this outcome. Our results point out that high standards of care and prevention for CVD risk factors should always be sought both in the HIV-infected and non-infected populations to prevent CVD-related events. PMID:27391355

  14. Novel markers of endothelial dysfunction and inflammation in Behçet's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio.

    Science.gov (United States)

    Yuksel, Murat; Yildiz, Abdulkadir; Oylumlu, Mustafa; Turkcu, Fatih Mehmet; Bilik, Mehmet Zihni; Ekinci, Aysun; Elbey, Bilal; Tekbas, Ebru; Alan, Sait

    2016-03-01

    The etiology of Behçet's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Behçet's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Behçet's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum ADMA concentration and CIMT are independently associated with BD. Neutrophil counts, NLR, and serum ADMA level were higher, and lymphocyte count was lower in patients with active ocular BD compared to those of inactive ocular BD group. Carotid intima media thickness, serum ADMA level, EFT, and NLR were increased in ocular BD patients compared to healthy subjects. In addition, both serum ADMA level and NLR were associated with disease activity of ocular involvement. Increase in disease duration was associated with increase in CIMT and EFT which suggests that anatomical changes occur in time during the disease course. Increased CIMT, serum ADMA level, EFT, and NLR may provide new clues about the role of ED and inflammation in the

  15. Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2

    Directory of Open Access Journals (Sweden)

    Allen J Taylor

    2007-03-01

    Full Text Available Allen J Taylor, Daming Zhu, Lance E Sullenberger, Hyun J Lee, Jeannie K Lee, Karen A Grace Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA Background: We previously reported in a placebo-controlled study that extended-release niacin slowed the progression of carotid atherosclerosis when added to statin monotherapy. This analysis examines the relationship between glycemic status and the effects of niacin on common carotid intima-media thickness (CIMT and HDL cholesterol.Methods: Post-hoc, subgroup analysis of ARBITER 2, a randomized, placebo-controlled trial of once-daily extended-release niacin (1000 mg added to background statin therapy in 167 patients (mean age 67 years with known coronary heart disease. The primary analysis was a comparison of the primary endpoint, the change in CIMT, between participants with either normal glycemic status, diabetes mellitus (DM or the metabolic syndrome (MS.Results: Baseline cardiovascular risk variables were significantly worse in those with abnormal glycemic status, particularly among subjects with MS. Niacin increased HDL-C to a similar degree (~20% across normals, DM and MS. Placebo-treated patients had the greatest CIMT progression, regardless of glycemic status. The lowest progression rate was observed in niacin treated patients with normal glycemic status. Among all niacin treated subjects, there was a significant linear relationship between change in CIMT and change in HDL-C (r = –0.16; p = 0.05, which was of similar magnitude in subgroups with normal glycemic status (r = –0.23; p = 0.08 and DM (r = –0.22; p = 0.17. In those with MS, there was no relationship between changes in HDL and CIMT, (r = 0.11; p = 0.44, whereas blood glucose was positive correlated to change in CIMT (r = 0.30; p = 0.04. In multivariable linear models controlling for MS characteristics and blood glucose changes, only the change in HDL independently predicted change in CIMT.Conclusions: During

  16. Anti-TNF-Alpha-Adalimumab Therapy Is Associated with Persistent Improvement of Endothelial Function without Progression of Carotid Intima-Media Wall Thickness in Patients with Rheumatoid Arthritis Refractory to Conventional Therapy

    Directory of Open Access Journals (Sweden)

    Carlos Gonzalez-Juanatey

    2012-01-01

    Full Text Available To determine whether treatment with the anti-TNF-alpha blocker adalimumab yields persistent improvement of endothelial function and prevents from morphological progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA refractory to conventional therapy, a series of 34 consecutive RA patients, attending hospital outpatient clinics and who were switched from disease modifying antirheumatic drug therapy to anti-TNF-alpha-adalimumab treatment because of severe disease, were assessed by ultrasonography techniques before the onset of adalimumab therapy (at day 0 and then at day 14 and at month 12. Values of flow-mediated endothelium-dependent vasodilatation at day 14 and at month 12 were significantly higher (mean ± standard deviation (SD: 6.1±3.9%; median: 5.7% at day 14, and mean ± SD: 7.4±2.8%; median: 6.9% at month 12 than those obtained at day 0 (mean: 4.5±4.0%; median: 3.6%; P=0.03 and P<0.001, resp.. Endothelium-independent vasodilatation results did not significantly change compared with those obtained at day 0. No significant differences were observed when carotid artery intima-media wall thickness values obtained at month 12 (mean ± SD: 0.69±0.21 mm were compared with those found at day 0 (0.65±0.16 mm (P=0.3. In conclusion, anti-TNF-alpha-adalimumab therapy has beneficial effects on the development of the subclinical atherosclerosis disease in RA.

  17. Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden: a cross sectional study using whole body magnetic resonance angiography.

    Directory of Open Access Journals (Sweden)

    Jonathan R Weir-McCall

    Full Text Available Common carotid intima media thickness (CIMT and ankle brachial pressure index (ABPI are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA.50 patients with symptomatic peripheral arterial disease were recruited. CIMT was measured using ultrasound while rest and exercise ABPI were performed. WB-MRA was performed in a 1.5T MRI scanner using 4 volume acquisitions with a divided dose of intravenous gadolinium gadoterate meglumine (Dotarem, Guerbet, FR. The WB-MRA data was divided into 31 anatomical arterial segments with each scored according to degree of luminal narrowing: 0 = normal, 1 = <50%, 2 = 50-70%, 3 = 70-99%, 4 = vessel occlusion. The segment scores were summed and from this a standardized atheroma score was calculated.The atherosclerotic burden was high with a standardised atheroma score of 39.5±11. Common CIMT showed a positive correlation with the whole body atheroma score (β 0.32, p = 0.045, however this was due to its strong correlation with the neck and thoracic segments (β 0.42 p = 0.01 with no correlation with the rest of the body. ABPI correlated with the whole body atheroma score (β -0.39, p = 0.012, which was due to a strong correlation with the ilio-femoral vessels with no correlation with the thoracic or neck vessels. On multiple linear regression, no correlation between CIMT and global atheroma burden was present (β 0.13 p = 0.45, while the correlation between ABPI and atheroma burden persisted (β -0.45 p = 0.005.ABPI but not CIMT correlates with global atheroma burden as measured by whole body contrast enhanced magnetic resonance angiography in a population with symptomatic peripheral arterial disease. However this is

  18. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis

    NARCIS (Netherlands)

    de Groot, E; Hovingh, GK; Wiegman, A; Duriez, P; Smit, AJ; Fruchart, JC; Kastelein, JJP

    2004-01-01

    Large observational studies and atherosclerosis regression trials of lipid-modifying pharmacotherapy have established that intima-media thickness of the carotid and femoral arteries, as measured noninvasively by B-mode ultrasound, is a valid surrogate marker for the progression of atherosclerotic di

  19. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ishida Hidenori

    2010-05-01

    Full Text Available Abstract Background To study the relationship between the intima-media thickness (IMT of the carotid artery and the stage of chronic kidney disease (CKD based on the estimated glomerular filtration rate (eGFR and diabetic nephropathy graded by the urinary albumin excretion (UAE in the patients with type 2 diabetes mellitus. Methods A cross-sectional study was performed in 338 patients with type 2 diabetes mellitus. The carotid IMT was measured using an ultrasonographic examination. Results The mean carotid IMT was 1.06 ± 0.27 mm, and 42% of the subjects showed IMT thickening (≥ 1.1 mm. Cerebrovascular disease and coronary heart disease were frequent in the patients with IMT thickening. The carotid IMT elevated significantly with the stage progression of CKD (0.87 ± 0.19 mm in stage 1, 1.02 ± 0.26 mm in stage 2, 1.11 ± 0.26 mm in stage 3, and 1.11 ± 0.27 mm in stage 4+5. However, the IMT was not significantly different among the various stages of diabetic nephropathy. The IMT was significantly greater in the diabetic patients with hypertension compared to those without hypertension. The IMT positively correlated with the age, the duration of diabetes mellitus, and the brachial-ankle pulse wave velocities (baPWV, and negatively correlated with the eGFR. In a stepwise multivariate regression analysis, the eGFR and the baPWV were independently associated with the carotid IMT. Conclusions Our study is the first report showing a relationship between the carotid IMT and the renal parameters including eGFR and the stages of diabetic nephropathy with a confirmed association between the IMT and diabetic macroangiopathy. Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients.

  20. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    Directory of Open Access Journals (Sweden)

    Priscila de Lima Sanches

    2012-10-01

    (IR n=39 and without insulin resistance (NIR n=27, and submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery intima-media thickness (cIMT, visceral and subcutaneous adipose tissue was determined by ultrasound. Body composition, blood pressure, HOMA-IR, lipid profile and adipokines concentrations [leptin, adiponectin, and plasminogen activator inhibitor type (PAI-1] were analyzed before and after the therapy. RESULTS: Both groups presented significant improvements in body composition, inflammatory state (reduction of leptin and PAI-1 concentration; increasing of plasma adiponectin and reduction of cIMT. Only NIR group showed positive correlation between changes in visceral fat (∆Visceral and changes in cIMT (∆ cIMT (r = 0.42; p < 0.05. Simple linear regression analyze revealed ∆Visceral to be an independent predictor to reduction of cIMT in this group (R2 adjusted = 0.14, p = 0.04. The final values of cIMT remained significantly higher in IR group when compared to NIR group. CONCLUSION: The presence of insulin resistance can impair changes in cIMT leading to early development of atherosclerosis in obese adolescents submitted to an interdisciplinary intervention..

  1. 糖尿病患者体脂分布与颈动脉内膜中层厚度关系%Relationship between body fat distribution and carotid intima media thickness in diabetes mellitus patients

    Institute of Scientific and Technical Information of China (English)

    季玉亮; 刘燕; 何立国; 孙静静; 王友强

    2015-01-01

    Objective To investigate application value of dual-energy X-ray absorptiometry (DEXA), and relationship between body fat distribution and carotid intima-media thickness (IMT). Methods Dual-energy X-ray absorptiometry was applied to detect body fat in 110 type 2 diabetes mellitus patients (diabetes mellitus group) and 79 normal people (control gorup), along with waistline diagnosis standard for consistency check. Diabetes mellitus patients were divided into diabetes mellitus central obesity (DMOB) group with 53 cases and diabetes mellitus non central obesity (DMNOB) group with 57 cases, according to waistline as golden standard for abdominal obesity and cut point of body fat percentage. Normal healthy people were divided into control central obesity (COB) group with 46 cases and control non central obesity (CNOB) group with 33 cases. Glycosylated hemoglobin and blood lipid were detected. B ultrasound was applied to detect carotid intima-media thickness for investigation of relationship between central obesity and atherosclerosis. Results DEXA had good consistency for detecting body fat distribution and waistline. There were statistically significant differences of carotid intima-media thickness in DMOB group, DMNOB group and control group (P<0.05). Conclusion Dual-energy X-ray absorptiometry in detection of body fat distribution can evaluate central obesity. There is a close relationship between body fat distribution and atherosclerosis in diabetes mellitus patients.%目的:探讨双能 X 线吸收技术(DEXA)在体脂测量方面的应用价值以及体脂分布与颈动脉内膜中层厚度(IMT)之间的关系。方法使用双能 X 线吸收技术测量110例2型糖尿病患者(糖尿病组)的体脂和79例正常健康人(对照组)的体脂。与腰围诊断标准进行一致性检验。以腹围为判断腹型肥胖的金标准找到躯干脂肪比例的切点并将糖尿病患者分为糖尿病中心性肥胖(DMOB)组53例和糖

  2. Distribution Characteristics and Related Factors of Carotid Intima-Media Thickness in Middle and Elder Aged Population%中老年人群颈动脉内中膜厚度分布特征及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    罗杰斯; 谢高强; 于洋; 王梦; 史平; 任福秀; 高炜; 武阳丰

    2013-01-01

    Objective:To explore the current distribution characteristics and related factors of carotid intima-media thickness in middle and elder aged population.Methods:From October to November 2012,the cross-sectional examination for cardiovascular risk factors and B-mode ultrasound imaging on carotid arteries were performed in participants at Shijingshan area in Beijing by China-US (PRC-USA) collaborative study.Results:The study investigated a total of 1345 people.There 1277 subjects at the age of (52~88) years with complete information were analyzed.The mean intima-media thickness (IMT) of carotid arteries was (0.68 ± 0.10) mm.The carotid IMT increased accordingly with the elevated age in both male and female genders and the trend analysis had the statistic meaning,P<0.001.The mean IMT in male was thicker than female at all age stages,P<0.01.Multivariate analysis presented that the mean IMT increased with the elevated age,systolic blood pressure,triglyceride and body mass index,P<0.05.Conclusion:In addition to age and gender,the blood pressure,glucose,lipids and obesity were related to carotid intima-media thickness,and those factors should be focused for cardiovascular disease prevention and treatment.%目的:探讨中老年人群颈动脉内中膜厚度分布特征的现状及其相关因素.方法:于2012-10至2012-11,对中美心血管病和心肺疾病流行病学合作研究中的石景山人群复查心血管病危险因素并进行颈动脉超声检查,以此横断面数据进行分析.结果:共计调查1345人.其中1 277人数据完整者纳入分析,年龄52~88岁.颈动脉内中膜厚度平均值为(0.68±0.10)mm,两性均随年龄而增加,趋势分析具有统计学意义(P<0.001).各年龄阶段颈动脉内中膜平均厚度男性均大于女性(P<0.01).多因素分析结果显示:男女两性颈动脉内中膜厚度随着年龄、收缩压、血糖、甘油三酯和体质指数的增加而增加(P<0.05).结论:除年龄和性别外,血

  3. Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study.

    Science.gov (United States)

    Geisel, Marie H; Coassin, Stefan; Heßler, Nicole; Bauer, Marcus; Eisele, Lewin; Erbel, Raimund; Haun, Margot; Hennig, Frauke; Moskau-Hartmann, Susanna; Hoffmann, Barbara; Jöckel, Karl-Heinz; Kedenko, Lyudmyla; Kiechl, Stefan; Kollerits, Barbara; Mahabadi, Amir-Abbas; Moebus, Susanne; Nürnberg, Gudrun; Nürnberg, Peter; Paulweber, Bernhard; Vens, Maren; Willeit, Johann; Willeit, Karin; Klockgether, Thomas; Ziegler, Andreas; Scherag, André; Kronenberg, Florian

    2016-06-01

    Carotid intima media thickness (cIMT) is a marker for subclinical atherosclerosis. The most recent genome-wide association meta-analysis (GWAMA) from the CHARGE consortium identified four genomic regions showing either significant (ZHX2, APOC1, PINX1) or suggestive evidence (SLC17A4) for an association. Here we assess these four cIMT loci in a pooled analysis of four independent studies including 5446 individuals by providing updated unbiased effect estimates of the cIMT association signals. The pooled estimates of our four independent samples pointed in the same direction and were similar to those of the GWAMA. When updating the independent second stage replication results from the earlier CHARGE GWAMA by our estimates, effect size estimates were closer to those of the original CHARGE discovery. A fine-mapping approach within a ±50 kb region around each lead SNP from CHARGE revealed 27 variants with larger estimated effect sizes than the lead SNPs but only three of them showed a r(2) > 0.40 with these respective lead SNPs from CHARGE. Some variants are located within potential functional loci. PMID:27085157

  4. The relationship of liver fat content and carotid intima media thickness%肝脏脂肪含量与颈动脉内膜中层厚度的相关性

    Institute of Scientific and Technical Information of China (English)

    罗玉琪; 潘晓平; 宗文红; 唐峻岭; 郝亚平; 马晓静; 朱家安; 包玉倩; 贾伟平

    2013-01-01

    Objective To explore the relationship between liver fat content and carotid intima media thickness (C-IMT) with ultrasound measurement.Methods 1217 subjects with complete data on physical examination,plasma glucose,blood pressure and lipid profile from a community of Shanghai Obesity Study (SHOS) between December 2009 and June 2010 were enrolled.All of them underwent carotid artery ultrasound scan and liver attenuation coefficient tested by ultrasonography to evaluate liver fat content.Subjects were grouped by tertile analysis of liver attenuation coefficient.The comparison of clinical indexes and C-IMT was conducted,using correlation analysis and multiple stepwise regression to explore the risk factors which affected C-IMT.Results (1) A total of 505 subjects (225 men and 280 women),who aged from 34 to 66 years old was diagnosed as non-Nonalcoholic fatty liver disease (NAFLD) without history of cardiovascular disease and non-carotid arterial plaque.Compared with those in the lowest tertile of liver attenuation coefficient,subjects in the highest group had significantly higher age (t =-2.41,P < 0.05)and diastolic blood pressure (DBP) (Z =-1.27,P < 0.05),and significantly lower waist circumference (W) (t =3.95,P < 0.05) and body mass index (BMI) (t =6.17,P < 0.05).(2) C-IMT significantly increased with the increment of liver attenuation coefficient (F =13.83,P < 0.05).The frequency of C-IMT elevation was also significantly higher in the highest tertile group compared with the lowest one (35.3% vs 23.2%,X2 =6.19,P <0.05).(3) Multiple stepwise regression analysis showed that liver attenuation coefficient was independent risk factor with C-IMT after adjustment of age,W,SBP fasting blood glucose (FBG) and smoking (β =0.03,P < 0.05).Conclusion Liver attenuation coefficient measured by ultrasonography is an effective method to identify liver fat content,which is closely correlated with C-IMT among undiagnosed NAFLD subjects by ultrasonography and it

  5. The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis

    OpenAIRE

    López-Mejías, Raquel; Genre, Fernanda; García-Bermúdez, Mercedes; Corrales, Alfonso; González-Juanatey, Carlos; Llorca, Javier; Miranda-Filloy, José A.; Rueda-Gotor, Javier; Blanco, Ricardo; Castañeda, Santos; Martín, J.; Miguel A. González-Gay

    2013-01-01

    Abstract Introduction Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In this study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis ...

  6. [Carotid and brachial intima-media thickness of the allelic variants G894T and T-789C of eNOS in systemic sclerosis patients].

    Science.gov (United States)

    Martínez-Godínez, Ángeles; Miliar-García, Ángel; Bautista-Jiménez, María Itandehui; Jandete-Rivera, Fernando; Vera-Lastra, Olga Lidia; Jara, Luis J; Bizueto-Rosas, Héctor; del Pilar Cruz-Domínguez, María

    2015-01-01

    Introducción: el objetivo de este estudio es evaluar comparativamente el grosor íntima-media (IMT) carotídeo y braquial con ultrasonido Doppler, la presión arterial pulmonar ecocardiográfica y la variación alélica de los genes G894T y T-789C de la eNOS en pacientes con esclerodermia. Métodos: estudio transversal en pacientes con esclerodermia. Criterios de inclusión: edad 18-70 años, diagnosticado con esclerodermia, previo consentimiento informado. Se evaluó IMT, índice de resistencia (IR) e índice de pulsatilidad (IP) mediante Doppler carotídeo y braquial, perfil de lípidos, proteína C reactiva, polimorfismo G894T y T-789C de óxido nítrico sin tasa endotelial (eNOS). Analizamos con estadística descriptiva, prueba t de Student o chi cuadrada para asociación de variables y Spearman para correlacionar las variables cuantitativas. Resultados: encontramos IMT anormalmente alto en arterias carotídeas y braquiales. Observamos baja correlación entre ambas braquiales, buena correlación entre carótidas y ninguna correlación entre carótidas y braquiales. El IMT braquial izquierdo > 0.65 corresponde con presión arteria pulmonar > 30 mmHg ecocardiográfica. El polimorfismo del gen G894T se asoció con mayor IMT en carótida derecha.Conclusión: El polimorfismo G894T de eNOS se asocia a mayor IMT en carótida derecha. El IMT carotídeo concuerda con su IMT contralateral. El IMT braquial izquierdo mayor a 0.65 sugiere la posibilidad de hipertensión arterial pulmonar.

  7. Grosor de la íntima-media de la arteria carótida en adolescentes obesos y su relación con el síndrome metabólico Intima-media thickness in obese adolescents and their relation with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    C. Torrejón

    2012-02-01

    Full Text Available Introducción: Los adolescentes obesos presentan mayor riesgo cardiovascular (RCV. La medición del grosor de la intima-media (GIM arterial detecta tempranamente el compromiso vascular. Objetivo: Evaluar si los adolescentes obesos tienen mayor compromiso vascular medido por GIM que los adolescentes no obesos, y si este es mayor en aquellos con síndrome metabólico (SM. Metodología: Grupo estudio (GE, niños obesos, IMC/edad > p95, con y sin SM y grupo control, IMC/edad p10-85, sin patología nutricional ni endocrina. Se midieron concentraciones séricas de lípidos, prueba tolerancia oral a glucosa con insulinemia y ecografía de arteria carótida. Para evaluar diferencia entre grupos se utilizaron pruebas estadísticas paramétricas y no paramétricas. Resultados: Se evaluaron 45 adolescentes obesos (20 mujeres, 19 con SM, edad 13 (9-16 años y 18 controles (14 mujeres, edad 13 (11-16 años. GIM del bulbo carotideo y de la arteria carótida interna (ACI fueron significativamente mayores en GE que grupo control (0,54 vs 0,34; 0,34 vs 0,25, p Introduction: Obese adolescents have higher cardiovascular risk (CVR. Intima-media thickness (IMT detects early arterial vascular compromise. Objective: To evaluate whether obese adolescents have higher vascular compromise measured by IMT than nonobese adolescents, and if this is greater in those with metabolic syndrome (MS. Method: The study group (SG, obese children (BMI/age > p95, with and without MS and control group (CG, non-obese (BMI/age p10-85 and non nutritional or endocrine disease. We measured serum lipids, oral glucose tolerance test with insulin and carotid artery ultrasound. To evaluate the differences between test groups we used parametric and nonparametric statistics. Results: We evaluated 45 obese adolescents (20 women, 19 with MS, age 13 (9-16 years and 18 controls (14 women, aged 13 (11-16 years. IMT of carotid bulb and internal carotid artery (ICA were significantly higher in SG than CG

  8. Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT in a Brazilian cohort of HIV-infected patients.

    Directory of Open Access Journals (Sweden)

    Antonio G Pacheco

    Full Text Available Combination antiretroviral therapy (cART had a dramatic impact on the mortality profile in human immunodeficiency virus (HIV infected individuals and increased their life-expectancy. Conditions associated with the aging process have been diagnosed more frequently among HIV-infected patients, particularly, cardiovascular diseases.Patients followed in the Instituto de Pesquisa Clínica Evandro Chagas (IPEC prospective cohort in Rio de Janeiro were submitted to the general procedures from the Brazilian Longitudinal Study of Adult Health, comprising several anthropometric, laboratory and imaging data. Carotid intima-media thickness (cIMT was measured by ultrasonography, following the Mannheim protocol. Linear regression and proportional odds models were used to compare groups and covariables in respect to cIMT. The best model was chosen with the adaptive lasso procedure.A valid cIMT exam was available for 591 patients. Median cIMT was significantly larger for men than women (0.56mm vs. 0.53mm; p = 0.002; overall = 0.54mm. In univariable linear regression analysis, both traditional risk factors for cardiovascular diseases (CVD and HIV-specific characteristics were significantly associated with cIMT values, but the best multivariable model chosen included only traditional characteristics. Hypertension presented the strongest association with higher cIMT terciles (OR = 2.51; 95%CI = 1.69-3.73, followed by current smoking (OR = 1,82; 95%CI = 1.19-2.79, family history of acute myocardial infarction or stroke (OR = 1.60; 95%CI = 1.10-2.32 and age (OR per year = 1.12; 95%CI = 1.10-1.14.Our results show that traditional cardiovascular disease (CVD risk factors are the major players in determining increased cIMT among HIV infected patients in Brazil. This finding reinforces the need for thorough assessment of those risk factors in these patients to guarantee the incidence of CVD events remain under control.

  9. 脑梗死患者同型半胱氨酸与颈动脉内膜中层厚度的关系%The Relationship between Homocysteine and Carotid Intima-Media Thickness in Patients with Brain Infarction

    Institute of Scientific and Technical Information of China (English)

    王渝; 张哲成; 朱炬; 张静; 王素红; 金凤艳; 杨新忠; 田丽

    2014-01-01

    Objective To investigate the relationship between total homocysteine (tHcy) and carotid intima-media thickness (CIMT) in brain infarction patients. Methods Sixty patients with fasting plasma tHcy levels ≤10μmol/L (non-Hhcy group), 60 patients with fasting plasma tHcy levels>10μmol/L and≤15μmol/L (H1 group), and 60 patients with fast-ing plasma tHcy levels>15μmol/L (H2 group) were chosen in hospitalized patients with acute cerebral infarction. Values of CIMT were detected in three groups of patients. The clinical biochemical indicators including triglyceride (TG), total choles-terol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), folic acid (FA), Vitamin B12 (VitB12) and glycated hemoglobin (HbA1c) were also detected. Results There was signifi-cant difference in CIMT between three groups (P15 μmol/L, there is more significantly higher level of CIMT. The increased CIMT level was associated with some cerebrovascular risk factors in patients with brain infarction.%目的:探讨脑梗死患者血浆总同型半胱氨酸(tHcy)与颈动脉内膜中层厚度(CIMT)的关系。方法从急性脑梗死住院患者中选取tHcy水平≤10μmol/L(非Hhcy组)、tHcy水平>10μmol/L且≤15μmol/L(H1组)、tHcy水平>15μmol/L(H2组)的患者各60例,测量3组患者CIMT,并检测三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBS)、叶酸(FA)、维生素B12(VitB12)、糖化血红蛋白(HbA1c)等临床生化指标。结果3组患者CIMT差异有统计学意义(P15μmol/L时CIMT明显增加,脑梗死患者CIMT增加与部分脑血管病危险因素有关。

  10. Measurement of the Common Carotid Arteries Intima-Media Thickness by Ultrasonography in Patients with Rheumatoid Arthritis.

    OpenAIRE

    Raouf Rahim Merza; Salah Muhammed Fateh; Hawar Ali Ehsan

    2014-01-01

    Purpose: Rheumatoid arthritis is a chronic inflammatory disabling disease affecting articular and extra articular organs and one of these important organs is cardiovascular system which its involvement is a leading cause of morbidity and mortality of Rheumatoid arthritis patients ; it is important to look for the relation of Rheumatoid arthritis and the extent of cardiovascular involvement among those patients by Ultrasound (US ) which is feasible, simple and low cost investigation and so...

  11. 2型糖尿病患者血清铁蛋白与颈动脉内中膜厚度的相关性%Relationship between serum ferritin and carotid intima-media thickness in patients with type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    张小青; 毕会民

    2012-01-01

    Objective To investigate the relationship between serum ferritin and carotid intima-media thickness in patients with type 2 diabetes mellitus (T2DM). Methods According to the intima-media thickness (IMT) of the carotid artery, 160 hospitalized patients with T2DM were divided into two groups,80 cases of thickened-CIMT group(B group),80 cases of normal-CIMT group(A group). The clinical data and serum ferritin of two groups were analyzed and compared. Results Fins, HOMA-IR, serum ferritin level in B group were higher than those in A group, FIns(5. 97 ± 0.59) mU/Lvs (7.42±0.08) mU/L;HOMA-IR 1.49±0.30 vs 2. 56±0. 02;SF(350. 33±6. 51) μg/L vs (473.33± 30. 55) μg/L. The serum ferritin level was positively correlated with IMT ( r =0.964, P <0. 01), fasting insulin( r = 0. 900, P <0. 05) ,and HOMA insulin resistance index( r =0. 943, P <0. 01). Conclusion Serum ferritin may take part in development of artherosderosis in patients with T2DM and higher level of SF is an important risk factor for IMT increase.%目的 探讨2型糖尿病(T2DM)患者颈动脉内中膜厚度与血清铁蛋白的关系.方法 根据颈动脉内中膜厚度(CIMT)将入选的160例T2DM患者分为CIMT正常组(A组)80例与CIMT增厚组(B组)80例,分别进行血清铁蛋白(SF)、空腹胰岛素(FIns)和胰岛素抵抗指数(HOMA-IR)等参数测定,采用高频彩色多普勒超声测定CIMT.结果 B组Fins、HOMA-IR和SF明显高于A组(P<0.05或<0.01),分别为Fins(5.97±0.59) mU/L vs (7.42±0.08) mU/L;HOMA-IR l.49±0.30 vs 2.56±0.02;SF(350.33±6.51) μg/L vs (473.33±30.55) μg/L; Spearman 相关性分析结果显示,SF水平与CIMT、Fins、HOMA-IR具有显著正相关(r=0.964、0.900、0.943,P<0.05或<0.01).结论 SF的升高可能参与了T2DM患者动脉粥样硬化的发生和发展,是CIMT增厚的危险因素.

  12. 川崎病恢复期颈动脉内膜-中膜厚度变化及相关因素分析%Study of carotid intima media thickness and its correlated factors in children at the convalescent phase of Kawasaki disease

    Institute of Scientific and Technical Information of China (English)

    牛峰海; 王瑜; 蔡文仙; 范国贞; 任雪云

    2012-01-01

    Objective To observe the change of carotid intima-media thickness and analysis of its correlated factors at the convalescent phase in children with Kawasaki disease, and to provide a scientific basis for prevention and treatment of vascular lesions. Methods A cohort of 60 children during the age of 2 to 4 years old was studied, which comprised 30 children at the convalescence phase of Kawasaki disease (KD group) and 30 healthy age-matched children (control group). Carotid arterial intima-media thickness (IMT) , malondialdehyde ( MDA) , interleukin-1 beta (IL-1|3) , interferon-gamma (IFN-7) and body mass index (BMI) were evaluated. Results IMT in KD group and control group was (0.40 ± 0.03) mm and (0.37 ± 0.04) mm respectively. IMT in KD group was higher than that in control group (P 0.05). IMT was positively correlated with the plasma level of MDA (r = 0.463, P < 0.05), but not significantly correlated with the levels of IL-iβ, IFN-7 and BMI. Conclusions The increased carotid IMT in children at the convalescent phase of Kawasaki disease is associated with oxidative stress.%目的 观察川崎病(KD)患儿恢复期颈动脉内膜-中膜厚度变化及相关因素,为防治KD血管病变提供科学依据.方法 收集30例2 ~ 4岁KD恢复期患儿及30例同年龄健康儿童,测定其颈动脉内膜-中膜厚度(IMT)、丙二醛(MDA)、白介素-1β(IL-1β)、γ-干扰素(IFN-γ)和体质指数(BMI).结果 KD患儿颈动脉IMT为(0.40 ± 0.03)mm,对照组为(0.37 ± 0.04)mm,两者比较差异有统计学意义.KD患儿MDA 为(2.56±0.18)nmol/ml,对照组为(2.09±0.24)nmol/ml,两者比较差异有统计学意义.两组间IL-1β、IFN-γ、BMI比较,差异均无统计学意义.直线相关分析显示,颈动脉IMT与MDA呈正相关(r = 0.463,P < 0.05),而与IL-1β、IFN-γ和 BMI水平均无相关性(P均> 0.05).结论 KD恢复期患儿颈动脉内膜-中膜增厚,与氧化应激有关.

  13. Clinical Significance of Arterial Stiffness and Thickness Biomarkers in Type 2 Diabetes Mellitus: An Up-To-Date Meta-Analysis

    OpenAIRE

    Yapei, Yang; Xiaoyan, Ren; Sha, Zeng; Li, Pan; Xiao, Meng; Shuangfeng, Chen; Lexin, Wang; Lianqun, Cui

    2015-01-01

    Background Type 2 Diabetes mellitus (T2DM) is associated with increased risk of cardiovascular disease (CVD). Previous studies explored the association of T2DM with arterial stiffness and thickness biomarkers including the augmentation index (AIX), aortic pulse wave velocity (aPWV), brachial-ankle PWV (baPWV), carotid intima-media wall thickness (IMT) as well as blood pressure (BP), low density lipoprotein cholesterol (LDL-C); however the conclusions are either inconsistent or incomprehensive...

  14. A discussion of the value of testing carotid intima-media thickness by ultrasound to cardio-cerebro-vascular disease%超声检测颈动脉内中膜厚度在心脑血管疾病中的价值探讨

    Institute of Scientific and Technical Information of China (English)

    杨丽丽; 余凤

    2015-01-01

    目的:探讨超声检测颈动脉内中膜厚度在心脑血管疾病中的应用价值。方法2012年1月~2014年6月我院超声检测颈动脉内中膜厚度共2167例,根据超声检测结果,分为正常组和异常组,统计两组患者心脑血管疾病患病情况。结果2167例受检者经超声检测,IMT异常893例(41.21%),其中,内中膜增厚112例(5.17%),粥样硬化斑块674例(31.10%),颈动脉狭窄107例(4.94%),以轻中度狭窄最为常见, IMT正常组中心血管病发病率为4.95%,异常组为35.95%,两组差异具有统计学意义(P<0.05);正常组中脑血管病发病率为3.53%,异常组为26.88%,两组差异具有统计学意义(P<0.05);IMT异常组中高血压和短暂性脑缺血发作(TIA)的发病率分别明显高于其他心脑血管疾病,差异具有统计学意义(x2a=6.569, P<0.05;x2b=7.247,P<0.05)。结论超声检测颈动脉内中膜厚度对心脑血管疾病早期预防、早期诊断、早期干预具有重要意义。%Objective To discuss the application value of testing carotid intima-media thickness by ultrasound to cardio-cerebro-vascular disease (CCVD).Methods 2167 cases tested carotid intima-media thickness by ultrasound in our hospital during January 2012 to June 2013 were divided into normal group and abnormal group according to the ultrasound attenuation detecting results. And the prevalence situation of CCVD of patients in the two groups was counted.Results2167 cases were examined by ultrasound in which 893 (41.21%)people's IMT were abnormal. Among them, 112 cases (5.17%)had thickening of their internal medial, 674 cases(31.10%) had atherosclerotic plaque, 107 cases(4.94%) were of carotid artery stenosis in which Mild-to-moderate carotid stenosis was the most common. The morbidity of cardiovascular disease was 4.95% in IMT normal group and 35.95% in abnormal group, it showed a significant difference between

  15. Medición del espesor miointimal carotídeo como predictor de riesgo de accidente isquémico transitorio Carotid Intima - Media Thickness measurement as a risk predictor of transient ischemic attack Objectives

    Directory of Open Access Journals (Sweden)

    Stella Maris Batallés

    2011-09-01

    Full Text Available Objetivos. Determinar si el riesgo de accidente isquémico transitorio (AIT es mayor en pacientes con valores anormales de espesor miointimal carotídeo (EMIC. Materiales y Métodos. Evaluación de 168 pacientes con y sin AIT estudiados con ecografías de vasos de cuello, midiendo EMIC. Diseño de casos y controles apareados por distintas variables. Análisis estadístico: variables continuas (media ± DS, comparadas mediante prueba "t de Student" para muestras relacionadas. Variables categóricas (porcentajes comparadas mediante pruebas de McNemar. Para evaluar EMIC como predictor de AIT, se ajustaron dos modelos de regresión logística condicional, considerando EMIC como variable continua y como variable binaria EMIC normal (1 mm. Se construyó una curva ROC para evaluar la capacidad discriminativa de EMIC, calculando la sensibilidad y especificidad para diferentes puntos de corte. Resultados. Valor de EMIC: casos 1,03 ± 0,31 mm (IC 95%: 0,97-1,10; controles 0,77 ± 0,27mm (IC 95%: 0,710,83; pTo determine if the risk of transient ischemic attack (TIA is higher in patients with abnormal values of carotid intima-media thickness (CIMT. Materials and Methods. We evaluated 168 patients with and without TIA by ultrasound of the neck vessels, measuring CIMT. Case and controls were matched according to different variables. Statistical analysis: continuous variables (mean ± SD were compared using the Student's t test for related samples. Categorical variables (percentages were compared using the McNemar tests. In order to assess CIMT as a predictor of TIA, two models of conditional logistic regression were adjusted, considering CIMT both as a continuous variable and as a binary variable: normal CIMT (1 mm. A ROC curve was performed to determine the discriminative capacity of CIMT, estimating the sensitivity and specificity for different cutoff values. Results. CIMT value: cases 1.03±0.31 mm (95% CI: 0.971.10; controls 0.77±0.27 mm (95% CI: 0

  16. Relationship between lipidemia and carotid intima-media thickness in patients with cerebral infarction%脑梗死患者血脂水平与颈动脉内中膜厚度的相关性分析

    Institute of Scientific and Technical Information of China (English)

    肖胜; 陈婧; 汪宏良; 肖劲松

    2012-01-01

    目的 探讨脑梗死(CI)患者血脂水平与颈动脉内中膜厚度(CIMT)的相关性.方法 测定120例CI患者(CI组)和120例神经科非CI患者(对照组)CIMT、血浆氧化低密度脂蛋白(ox-LDL)及血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B (Apo-B)、脂蛋白(a)[ LP(a)]水平,并进行相关分析.结果 CI组TC、TG、Apo-B、LP(a)和ox-LDL水平高于对照组(P< 0.01);CI组CIMT检测结果 为1.1±0.32 mm,高于对照组的0.8±0.54 mm(P<0.01);CI组TC、TG、LDL-C、Apo-B 、LP(a)、ox-LDL与CIMT呈正相关(P<0.01),HDL-C、Apo-A1与CIMT呈负相关(P<0.01).结论 脂代谢异常与CI患者动脉粥样硬化密切相关;CI患者体内可能存在脂质过氧化反应;抑制脂质过氧化,减少ox-LDL的生成有助于预防和治疗CI.%Objective To investigate the relationship between lipidemia and carotid intima-media thickness (CIMT) in patients with cerebral infarction(CI). Methods CIMT,plasma oxidized low-density lipoprotein(ox-LDL)level and serum level of total cho-lesterol(TC) , triacylglycerol (TG) , low density lipoprotein-cholestero ( LDL-C) , high density lipoprotein-cholestero( HDL-C) , ap-oprotein AL(Apo-Al) ,apoprotein B(Apo-B) and lipoprotein(a)[LP(a)] were detected in 120 cases of patients with CI(CI group) and 120 non-CI subjects(control group). Results Levels of TC,TG, Apo-B, LP(a) and ox-LDL in CI group were higher than those in control group (P< 0. 01). CIMT of CI group was 1. 1 ± 0. 32 mm, which was higher than 0. 8 ± 0. 54 mm of control group(P< 0. 01). In CI group,TC,TG, LDL-C, Apo-B,LP(a) and ox-LDL were positively correlated with CIMT(P<0. 01) ,but HDL-C and Apo-Al were negatively correlated with CIMT(P<0. 01). Conclusion There could be certain correlation between abnormal lipid metabolism and atherosclerosis in patients with CI. There could be peroxidatic reaction of lipid in patients with CI

  17. Roles of carotid intima-media thickness and microalbuminuria in evaluating cardiovascular risk for polyvascular atherosclerosis patients%颈动脉内中膜厚度及尿微量白蛋白在多动脉粥样硬化患者心血管危险评估中的作用

    Institute of Scientific and Technical Information of China (English)

    肖华; 迟路湘

    2011-01-01

    Objective To identify the relationship of carotid intima-media thickness (CIMT),microalbuminuria (MA) level, and atherosclerosis extent with the rate of cardiovascular events in patients with polyvascular atherosclerosis. Methods A total of 149 patients with polyvascular atherosclerosis with angiographic arterial stenosis ≥ 50% in 1, 2, 3 or 4 territories ( coronary, supraaortic, renal and/or lower limb arteries) who admitted in our hospital from June 2007 to June 2009 and underwent revascularization procedure in ≥ 1 arterial territory were enrolled in this study. These patients were divided into 4 groups according to their atherosclerosis extent, group 1 with stenosis in 1 territory ( n = 40), group 2 in 2 territories ( n = 40), group 3 in 3 territories ( n = 37 ), and group 4 in 4 territories ( n = 32). Baseline mean-CIMT and MA was assessed in the 149 patients and 40 control subjects who were suspected with arterial stenosis but diagnosed without after angiography at the time of hospitalization. Incidence of cardiovascular events were observed during the follow-up of 14.6 ± 4.9 months. Results For CIMT ≥ 1.38 mm ( ≥3rd quartile), the sensitivity and specificity of ≥ 3-territory involvement were 90.0% and 82.6%. For MA≥6.85 mg/dl ( ≥3rd quartile), the sensitivity and specificity of ≥ 2-territory involvement were 54.9% and 83.3%. Cardiovascular events occurred in 104 subjects of 149 patients. The Kaplan Meier 2-year cardiovascular event-free survival was 93.9% and 95.7%,95.7% and 89.6%, 73.9% and 72.3%; and 59.6% and 66.0% respectively in patients with mean-CIMT and MA values in the 1st, 2nd, 3rd and 4th quartile. The multivariable Cox proportional hazard model identified that mean-CIMT ≥1.38 mm (RR = 1.83, 95% CI = 1. 049 to 3. 196; P <0.001 ) and MA ≥6.84 mg/dl (RR =0.99, 95% CI =0.576 to 1. 703; P <0.001 ) were independant adverse event predictors. Inclusion of CIMT into the stratification model

  18. Carotid Artery Wall Layer Dimensions during and after Pre-eclampsia : An investigation using non-invasive high-frequency ultrasound

    OpenAIRE

    Akhter, Tansim

    2013-01-01

    Pre-eclampsia is associated with increased risk of cardiovascular disease (CVD) later in life. The ‘gold standard’ for estimating cardiovascular risk - ultrasound assessment of the common carotid artery intima-media thickness (CCA-IMT) - does not convincingly demonstrate this increased risk. The aim of this thesis was to examine whether high-frequency (22 MHz) ultrasound assessment of the individual CCA intima and media layers and calculation of the intima/media (I/M) ratio - can indicate the...

  19. Despeckle Filtering for Multiscale Amplitude-Modulation Frequency-Modulation (AM-FM) Texture Analysis of Ultrasound Images of the Intima-Media Complex

    Science.gov (United States)

    Loizou, C. P.; Murray, V.; Pattichis, M. S.; Pantziaris, M.; Nicolaides, A. N.; Pattichis, C. S.

    2014-01-01

    The intima-media thickness (IMT) of the common carotid artery (CCA) is widely used as an early indicator of cardiovascular disease (CVD). Typically, the IMT grows with age and this is used as a sign of increased risk of CVD. Beyond thickness, there is also clinical interest in identifying how the composition and texture of the intima-media complex (IMC) changed and how these textural changes grow into atherosclerotic plaques that can cause stroke. Clearly though texture analysis of ultrasound images can be greatly affected by speckle noise, our goal here is to develop effective despeckle noise methods that can recover image texture associated with increased rates of atherosclerosis disease. In this study, we perform a comparative evaluation of several despeckle filtering methods, on 100 ultrasound images of the CCA, based on the extracted multiscale Amplitude-Modulation Frequency-Modulation (AM-FM) texture features and visual image quality assessment by two clinical experts. Texture features were extracted from the automatically segmented IMC for three different age groups. The despeckle filters hybrid median and the homogeneous mask area filter showed the best performance by improving the class separation between the three age groups and also yielded significantly improved image quality. PMID:24734038

  20. Optical coherence tomography layer thickness characterization of a mock artery during angioplasty balloon deployment

    Science.gov (United States)

    Azarnoush, Hamed; Vergnole, Sébastien; Boulet, Benoît; Lamouche, Guy

    2011-03-01

    Optical coherence tomography (OCT) is used to study the deformation of a mock artery in an angioplasty simulation setup. An OCT probe integrated in a balloon catheter provides intraluminal real-time images during balloon inflation. Swept-source OCT is used for imaging. A 4 mm semi-compliant polyurethane balloon is used for experiments. The balloon is inflated inside a custom-built multi-layer artery phantom. The phantom has three layers to mock artery layers, namely, intima, media and adventitia. Semi-automatic segmentation of phantom layers is performed to provide a detailed assessment of the phantom deformation at various inflation pressures. Characterization of luminal diameter and thickness of different layers of the mock artery is provided for various inflation pressures.

  1. Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.

    Directory of Open Access Journals (Sweden)

    Jouni Karppi

    Full Text Available BACKGROUND: Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. We assessed the association between atherosclerotic progression, measured by intima-media thickness of the common carotid artery wall, and serum levels of carotenoids. METHODS: We studied the effect of carotenoids on progression of early atherosclerosis in a population-based study. The association between concentrations of serum carotenoids, and intima-media thickness of the common carotid artery wall was explored in 840 middle-aged men (aged 46-65 years from Eastern Finland. Ultrasonography of the common carotid arteries were performed at baseline and 7-year follow-up. Serum levels of carotenoids were analyzed at baseline. Changes in mean and maximum intima media thickness of carotid artery wall were related to baseline serum carotenoid levels in covariance analyses adjusted for covariates. RESULTS: In a covariance analysis with adjustment for age, ultrasound sonographer, maximum intima media thickness, examination year, body mass index, systolic blood pressure, smoking, physical activity, serum LDL cholesterol, family history of coronary heart disease, antihypertensive medication and serum high sensitivity C-reactive protein, 7-year change in maximum intima media thickness was inversely associated with lycopene (p = 0.005, α-carotene (p = 0.002 and β-carotene (p = 0.019, respectively. CONCLUSIONS: The present study shows that high serum concentrations of carotenoids may be protective against early atherosclerosis.

  2. Correlation Study of Carotid Intima_media Thickness,Carotid Plaques and SYNTAX Score in Patients with Coronary Heart Disease%冠心病患者颈动脉内膜中层厚度及颈动脉斑块与 SYNTAX 评分的相关性研究

    Institute of Scientific and Technical Information of China (English)

    王林; 袁国裕; 陈国雄; 陈士良

    2016-01-01

    Objective To explore the association of carotid intima_media thickness (CIMT ) ,carotid plaques with SYNTAX score of coronary artery in patients with coronary heart disease(CHD). Methods 256 patients who underwent coronary arteriography (CAG) were divided into control group with their coronary stenosis 32scores).CIMT and catotid plaques were evaluated with ultrasonic inspection and measurement in all patients. Results Incidence rates of elevated CIMT and carotid plaques were significantly higher in CHD group than in the control group ( P32scores) than in the low risk group (1~22scores). The Spearman linear_regression analysis showed that SYNTAX scores had a positive correlation with CIMT ( r=0.64 ,P32 ( P<0.05).Conclusions CIMT and carotid plaques were closely associated with SYNTAX scores in patients with CHD ,which could be used to indirectly predict the severity of coronary artery lesion.%目的:探讨冠心病患者颈动脉内膜中层厚度(CIMT )及颈动脉斑块与冠状动脉SYNTAX评分的关系。方法选择行冠状动脉造影的患者256例,根据冠状动脉造影结果分组:51例冠状动脉狭窄<50%为对照组,余205例为冠心病组。冠心病组又根据SYNTAX评分结果分为低分组(1~22分)70例、中分组(23~32)94例、高分组(>32分)41例。所有患者均采用超声检测双侧CIMT及颈动脉斑块情况。结果与对照组比较,冠心病组患者CIMT及斑块发生率明显高于对照组( P<0.05)。与低分组比较,中分组和高分组CIMT及斑块发生率明显升高( P<0.05)。Spearman线性回归分析结果显示冠心病患者CIMT与SYNTAX评分呈直线正相关( r=0.64,P<0.01)。多因素Logistic回归分析结果显示,CIMT及颈动脉斑块是SYNTAX积分>32分的独立预测因素( P<0.05)。结论 CIMT及颈动脉斑块与冠心病患者SYNTAX评分密切相关,可间接预测冠状动脉病变严重程度。

  3. Correlation between Syndrome Differentiation and Treatment Uariation of Metabolic Syndrome and Urine Trace Albumin and Intima Media Thickness%代谢综合征中医辨证分型与尿微量白蛋白及颈动脉内膜中层厚度关系

    Institute of Scientific and Technical Information of China (English)

    赵娜; 刘莉; 隋艳波

    2015-01-01

    Objective:To explore the relationship between the urine trace albumin and intima media thickness among Met-abolic Syndrome ( MS) patients with different traditional Chinese medicine( TCM) syndromes, and to provide some ob-jective basis for syndrome differentiation and treatment variation.Methods:Eighty patients were enrolled and assigned to inter-stagnation phlegm and blood stasis type, Qi stagnation and dampness obstruction type, Qi asthenia of the spleen and kidney type, asthenia of Qi and Yin type according to TCM syndrome.Ccompare the general information,the urine trace albumin and intima media thickness among them.Results:MAU of MS patients with inter-stagnation phlegm and blood stasis type was higher than Qi stagnation and dampness obstruction type and Qi asthenia of the spleen and kidney type ( P<0.05 ); IMT of MS patients with inter-stagnation phlegm and blood stasis type was much greater than Qi stagnation and dampness obstruction type (P<0.01), and was also greater than Qi asthenia of the spleen and kidney type and asthenia of Qi and Yin type (P<0.05).Conclusion:MS patients with inter-stagnation phlegm and blood sta-sis type shouldpay more attention to the prevention and treatment of renal and vascular complications,and urine trace al-bumin and intima media thickness can be a reference of traditional Chinese medicine in patients with MS.%目的:探讨代谢综合征( MS)患者不同中医证型的尿微量白蛋白及颈动脉内膜中层厚度的关系,为中医辨证论治提供一定的客观依据。方法:选择MS患者80例,根据中医证候分为痰瘀互结型,气滞湿阻型,脾肾气虚型和气阴两虚型。对患者的一般资料、尿微量白蛋白检测结果及颈动脉内膜中层厚度进行比较。结果:MS痰瘀互结型患者的MAU高于气滞湿阻型及脾肾气虚型( P<0.05);MS痰瘀互结型患者的IMT大于气滞湿阻型(P<0.01),大于脾肾气虚型及气阴两虚型(P<0.05)

  4. Relationships between circadian rhythm of ambulatory blood pressure and vascular endothelial function and carotid intima-media thickness in prehypertensives%正常高值血压者动脉血压昼夜节律与血管内皮功能及颈动脉内膜中层厚度的关系

    Institute of Scientific and Technical Information of China (English)

    梁薇芬; 张赛丹

    2012-01-01

    Objective To investigate the relationships between circadian rhythm of ambulatory blood pressure and carotid arterial intima-media thickness (IMT), vascular endothelial function assessed by flow mediated dilation (FMD) in prehypertensives. Methods One hundred and four prehypertensives collected continually from the physical examination center of Xiangya hospital between August 2010 and December 2010 were divided into two groups according to the circadian rhythm of ambulatory blood pressure monitoring (ABPM): the dipper group (55 cases) and the non-dipper group (49 cases). Forty normotensives were enrolled as control group. FMD and IMT were detected by high resolution ultrasonography. Results Dipper pattern and non-dipper pattern of prehypertension accounted for 52. 9% and 47. 1% respectively. Compared to the control group, IMT values of two prehypertensive groups were higher [(0. 74±0. 06), (0. 75±0. 06) vs (0. 47±0. 05)mm, while the FMD values were lower (8. 07 + 1.18)%, (5.89 + 0.93)% vs (13. 78±1. 98)%, all P<0. 05]. The FMD value of dipper group was higher than that of non-dipper group. FMD value was negatively correlated with IMT (r= -0. 843, P<0. 01). Conclusion Prehypertensives demonstrated abnormal ABPM rhythm, increased IMT value and decreased FMD. Compared to dipper prehypertensives, non-dipper individuals showed a more severe impairment of endothelial function as manifested by a reduced ability of FMD.%目的 了解正常高值血压动态血压昼夜节律及血管内皮功能(FMD)、颈动脉内膜中层厚度(IMT),探讨三者之间的关系.方法 连续收集2010-08-12湘雅医院体检中心正常高值血压者104例,根据动态血压昼夜变化规律分为杓型组(55例)和非杓型组(49例),健康体检者40例为对照组.高分辨超声检测肱动脉FMD及颈动脉IMT.结果 正常高值血压动态血压呈杓型及非杓型各占52.9%及47.1%,杓型组与非杓型组的IMT大于对照组[(0.74±0.06)、(0.75±0.06)比(0.47±0

  5. Smoking status and common carotid artery intima-medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study

    OpenAIRE

    Merz C Noel; Paul-Labrador Maura; Fan Amy Z; Iribarren Carlos; Dwyer James H

    2006-01-01

    Abstract Background Cigarette smoking is an established causal factor for atherosclerosis. However, the smoking effect on different echogenic components of carotid arterial wall measured by ultrasound is not well elucidated. Methods Middle-aged men and women who had IMT measurement ≥ 0.7 mm at baseline and follow-up were included (N = 413, age 40–60 years at baseline in 1995). Intima-media thickness of common carotid artery (CCA-IMT) and its components (echogenic and echolucent layers) were m...

  6. 维持性血液透析患者微炎症状态与颈动脉内中膜厚度进展的相关性研究%Correlation between the micro-inflammatory state of maintenance hemodialysis patients and progression of carotid intima-media thickness

    Institute of Scientific and Technical Information of China (English)

    张晓东; 张建荣; 朱愿; 宋洁; 李瑛; 李辉

    2012-01-01

    Objective To explore the correlation between the micro - inflammatory state of patients of maintenance hemodialy-sis and progression of carotid intima - media thickness ( PROG - IMT) . Methods The high - sensitivity C - reactive protein level ( hs - CRP) of 93 standard - compliant MHD patients was measured by ELISA. According to the results, these patients were divided into normal group (30 cases, hs - CRP levels 0.05). There was one death from cardiovascular and cerebrovascular diseases. (2) PROG - IMT, hs - CRP, age, blood pressure, and low density lipoprotein were positively correlated (P 0.05);因心脑血管疾病死亡1例.(2)PROG-IMT 与hs-CRP、年龄、血压、低密度脂蛋白正相关(P<0.05).(3)多元逐步回归分析显示,hs-CRP 是影响PROG-IMT 的主要因素(P<0.05).结论 微炎症状态MHD 患者IMT 呈进行性进展,血清hs-CRP 水平是影响PROG-IMT 的主要因素.

  7. Growth hormone (GH) and atherosclerosis: changes in morphology and function of major arteries during GH treatment.

    Science.gov (United States)

    Pfeifer, M; Verhovec, R; Zizek, B

    1999-04-01

    Patients with hypopituitarism have increased carotid artery intima-media thickness and reduced arterial distensibility. The effect of 2 years of growth hormone (GH) replacement therapy on these parameters was studied in 11 GH-deficient men (age range, 24-49 years) with hypopituitarism and compared with 12 healthy, age-matched men with no evidence of pituitary or vascular disease. Before treatment the intima-media of the common carotid arteries and the carotid bifurcations were significantly thicker in patients (P < 0.001) than in the control group. Treatment with GH normalized the intima-media thickness of the common carotid artery within 6 months and of the carotid bifurcation within 3 months. The changes in intima-media thickness of the carotid artery were negatively correlated with changes in serum levels of insulin-like growth factor I during treatment. There was a significant improvement in flow-mediated, endothelium-dependent dilation of the brachial artery at 3 months, which was sustained at 6, 18 and 24 months of GH treatment (P < 0.05). Thus, GH replacement therapy in GH-deficient men reverses early morphological and functional atherosclerotic changes in major arteries, and may reduce rates of vascular morbidity and mortality.

  8. Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

    OpenAIRE

    Raquel López-Mejías; Fernanda Genre; Mercedes García-Bermúdez; Begoña Ubilla; Santos Castañeda; Javier Llorca; Carlos González-Juanatey; Alfonso Corrales; Miranda-Filloy, José A.; Trinitario Pina; Carmen Gómez-Vaquero; Luis Rodríguez-Rodríguez; Benjamín Fernández-Gutiérrez; Alejandro Balsa; Dora Pascual-Salcedo

    2014-01-01

    Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordin...

  9. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

    Science.gov (United States)

    Vázquez-Del Mercado, Mónica; Nuñez-Atahualpa, Lourdes; Figueroa-Sánchez, Mauricio; Gómez-Bañuelos, Eduardo; Rocha-Muñoz, Alberto Daniel; Martín-Márquez, Beatriz Teresita; Martínez-García, Erika Aurora; Macias-Reyes, Héctor; Gamez-Nava, Jorge Ivan; Navarro-Hernandez, Rosa Elena; Nuñez-Atahualpa, María Alejandra; Andrade-Garduño, Javier

    2015-01-01

    The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients. Methods. Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied. All groups were assessed for atherogenic index of plasma (AIP) and cIMT. Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA). Results. The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P < 0.001). Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFα and IL-6 (P < 0.01), and lower levels of high density lipoprotein cholesterol (HDL-c) (P = 0.02). The cIMT correlated with levels of anti-CCP (r = 0.513, P = 0.001), CRP (r = 0.799, P < 0.001), TNFα (r = 0.642, P = 0.001), and IL-6 (r = 0.751, P < 0.001). In multiple regression analysis, cIMT was associated with CRP (P < 0.001) and anti-CCP levels (P = 0.03). Conclusions. Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events. PMID:25821796

  10. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

    Directory of Open Access Journals (Sweden)

    Mónica Vázquez-Del Mercado

    2015-01-01

    Full Text Available The main cause of death in rheumatoid arthritis (RA is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP antibody levels with increased carotid intima-media thickness (cIMT in RA patients. Methods. Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC were studied. All groups were assessed for atherogenic index of plasma (AIP and cIMT. Anti-CCP, C-reactive protein (CRP, and levels of tumor necrosis factor alpha (TNFα and interleukin-6 (IL-6 were measured by enzyme-linked immunosorbent assay (ELISA. Results. The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P<0.001. Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFα and IL-6 (P<0.01, and lower levels of high density lipoprotein cholesterol (HDL-c (P=0.02. The cIMT correlated with levels of anti-CCP (r=0.513, P=0.001, CRP (r=0.799, P<0.001, TNFα (r=0.642, P=0.001, and IL-6 (r=0.751, P<0.001. In multiple regression analysis, cIMT was associated with CRP (P<0.001 and anti-CCP levels (P=0.03. Conclusions. Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.

  11. 肥胖中青年男性颈动脉内中膜厚度相关危险因素分析%Analysis of the Related Risk Factors of Carotid Intima-media Thickness in Middle-age and Young Men with Obesity

    Institute of Scientific and Technical Information of China (English)

    杨青; 陆强; 刘晓丽

    2013-01-01

    [目的]探讨肥胖中青年男性人群颈动脉内中膜厚度(CIM T )的相关危险因素。[方法]选取81例20~50岁男性为研究对象。根据体质量指数(BM I)分为肥胖组28例(BM I >28 kg/m2)、超重组25例(BM I=25~28 kg/m2)和对照组28例( BM I<25 kg/m2)三组。检测三组的血糖、血脂、尿酸(U A )、睾酮(T )、胰岛素抵抗指数及人体基本参数。[结果]中青年男性肥胖组BMI、收缩压(SBP)、甘油三脂(TG)、总胆固醇(TC)、UA、胰岛素抵抗指数(HOMA-IR)均高于超重组及对照组( P <0.05),与CIMT正相关,高密度脂蛋白胆固醇(HDL-C)、T低于超重组及对照组( P <0.05),与IMT呈负相关。多元线性回归显示BMI、TG是颈动脉内中膜异常的相关独立危险因素。[结论]肥胖组中青年男性存在CIMT增厚。BMI及TG是CIMT独立危险因素。%[Objective]To explore the related risk factors of carotid intima-media thickness(CIMT) in middle-age and young men with obesity .[Methods]Totally 81 men aged 20~50 years were enrolled in the study .Accord-ing to body mass index(BMI) ,all subjects were divided into obese group( n =28 ,BMI>28 kg/m2 ) ,overweight group( n=25 ,BMI=25~28 kg/m2 ) and control group( n=28 ,BMI<25 kg/m2 ) .Blood sugar ,lipids ,uric acid (UA) ,testosterone(T) ,insulin resistance index (HOMA-IR) and anthropometric parameters of 3 groups were measured .[Results]BMI ,SBP ,TG ,TC ,UA and HOMA-IR in middle-age and young obesity group were higher than those in overweight group and control group( P <0 .05) ,and positively correlated with CIMT .HDL-C and T in middle-age and young obesity group were lower than those in overweight group and control group ( P <0 .05) ,and negatively correlated with IMT .Multivariant linear regression analysis showed that BMI and TG were the relative independent risk factors of abnormal carotid intima-media .[Conclusion]CIM T in middle-age and young men

  12. Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults

    NARCIS (Netherlands)

    Durga, Jane; Bots, Michiel L.; Schouten, Evert G.; Grobbee, Diederick E.; Kok, Frans J.; Verhoef, Petra

    2011-01-01

    Background: Observational studies have shown that low folate and elevated homocysteine concentrations are risk factors for vascular disease in the general population. Randomized controlled trials in vascular patients have failed to show that folic acid reduces the risk of recurrent vascular disease,

  13. Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

    Directory of Open Access Journals (Sweden)

    Ramachandran Meenakshisundaram

    2011-01-01

    Conclusions: IMT of the carotid and thoracic aorta is strongly associated with risk of CAD in a South Indian population, and may be used as a non-invasive screening tool for coronary atherosclerosis in resource-limited settings. The presence of dyslipidemia influenced IMT and may be used as a tool to follow patients on hypolipidemic drugs.

  14. Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients

    Directory of Open Access Journals (Sweden)

    Haohui Zhu

    2014-09-01

    Full Text Available Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China. Method: Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative artery stiffness, respectively. Results: No statistically significant difference in carotid artery intima-media thickness and stiffness was observed between groups. A significant association between human immunodeficiency virus infection time and carotid artery stiffness was observed, but no significant association between human immunodeficiency virus infection time and intima-media thickness was found. No significant association between intima-media thickness, stiffness, and CD4+ and CD8+ T-cell counts were observed. Conclusion: The first-line highly active antiretroviral therapy currently used in China is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients with good highly active antiretroviral therapy compliance. Human immunodeficiency virus may play a role in the development of atherosclerosis.

  15. The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis

    Directory of Open Access Journals (Sweden)

    Green Daniel J

    2008-09-01

    Full Text Available Abstract Background Experimental and epidemiological evidence suggests that homocysteine (tHcy may be a causal risk factor for atherosclerosis. B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown. Methods We conducted a sub-study of VITATOPS, a randomised, double-blind, placebo-controlled intervention trial designed to test the efficacy of long term B-vitamin supplementation (folic acid 2 mg, vitamin B6 25 mg and vitamin B12 0.5 mg in the prevention of vascular events in patients with a history of stroke. We measured carotid intima-medial thickness (CIMT and flow-mediated dilation (FMD at least two years after randomisation in 162 VITATOPS participants. We also conducted a systematic review and meta-analysis of studies designed to test the effect of B-vitamin treatment on CIMT and FMD. Results After a mean treatment period of 3.9 ± 0.9 years, the vitamin-treated group had a significantly lower mean plasma homocysteine concentration than the placebo-treated group (7.9 μmol/L, 95% CI 7.5 to 8.4 versus 11.8 μmol/L, 95% CI 10.9 to 12.8, p Conclusion Although short-term treatment with B-vitamins is associated with increased FMD, long-term homocysteine-lowering did not significantly improve FMD or CIMT in people with a history of stroke. Trial Registration Clinical Trial Registration URL: http://www.actr.org.au/ Trial Registration number: 12605000005651

  16. Insulin sensitivity and carotid intima-media thickness

    DEFF Research Database (Denmark)

    Kozakova, Michaela; Natali, Andrea; Dekker, Jacqueline;

    2013-01-01

    Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. APPROACH AND RESULTS: We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions know...

  17. Effects of Pioglitazone on the Carotid Intima-media Thickness and Serum Adhesion Molecules Levels of Type 2 Diabetic Patients%吡格列酮对2型糖尿病患者早期动脉硬化和黏附分子水平的影响

    Institute of Scientific and Technical Information of China (English)

    赵永才; 李新胜; 钱红霞; 黄福常; 常涛

    2012-01-01

    目的 研究2型糖尿病患者血清可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性细胞间黏附分子-1(sICAM-1)水平和颈动脉内膜中层厚度( carotid intima-media thickness,CIMT)的关系以及吡格列酮治疗对其的影响.方法 将150例2型糖尿病患者随机分为治疗组和对照组.治疗组在原治疗基础上给予吡格列酮15 mg/d,治疗6个月,观察吡格列酮治疗前后血糖、血脂、sVCAM-1、sICAM-1和CIMT水平变化及与对照组之间的差别.结果 与治疗前比较,两组治疗后血糖均下降,差异有统计学意义(P<0.05),治疗组治疗后sVCAM-1、sICAM-1和CIMT较治疗前显著降低,差异有统计学意义(P<0.05).对照组治疗前后sVCAM-1、sICAM-1和CIMT差异无统计学意义(P<0.05).多元线性逐步回归分析显示,CIMT变化与体质指数(BMI)餐后2h血糖(2h PG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、sVCAM-1和sICAM-1有关,相关系数分别为0.298、0.358、0.381、0.368、0.580、0.572(均P<0.05).结论 血清sVCAM-1和sICAM-1水平与2型糖尿病早期大血管病变关系密切,吡格列酮能显著降低2型糖尿病患者血清sVCAM-1和sICAM-1水平,这可能是吡格列酮血管保护的作用机制之一.%Objective To observe the changes of carotid intima-media thickness (C1MT) ,serum soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercelluar adhesion molecule (slCAM-1) levels in type 2 diabetic patients, and to study the effect of pioglitazone on CIMT and sVCAM-1, sICAM-1 levels. Methods One hundred and five type 2 diabetic patients were randomly divided into a treatment group and a control group.The control group (n=75) received routine therapy alone. The treatment group was treated with pioglitazone 15 mg/d on the basis routine therapy for six months. Levels of sVCAM-1, sICAM—1, plasma glucose, plasma lipids and CIMT were detected before and after treatment. Results The mean level of plasma glucose of two groups was lower than

  18. Relationship between carotid intima-media thickness and glomerular filtration rate in type 2 diabetic patients%2型糖尿病患者颈动脉内中膜厚度与肾小球滤过率的相关性分析

    Institute of Scientific and Technical Information of China (English)

    贾艳坤; 韩丽萍; 谢云

    2012-01-01

    Objective To investigate the correlation between carotid intima-media thickness (cIMT) and glomerular filtration rate (GFR) in type 2 diabetic patients. Methods 143 patients whose age is above 45 years were selected and the patients' blood pressure should be controlled below 140/90 mmHg. The patients were divided into two groups: the normal group (cIMT<0. 9 mm) and the thick group (cIMT≥0. 9 mm) by the cut level of cIMT 0. 9 mm. The age. Duration. MAU frequency, GFR and biochemical indexes were compared between them. Results cIMT thick group's age, duration and MAU frequency were much higher than those of cIMT normal group, and the GFR of the thick group was much lower than that of the normal group (P<0. 05). No statistical difference was found in biochemical indexes such as fasting glucose and lipids between two groups. Multiple stepwise regression analysis showed cIMT had a positive correlation with age, duration, and had a negative correlation with eGFR Conclusions With the development of the atherosclerosis, GFR gradually decreases and contributes to the occurance and development of early-stage atherosclerosis.%目的 探讨T2DM患者颈动脉内中膜厚度(cIMT)与肾小球滤过率(GFR)的相关性.方法 随机选取年龄>45岁的血压控制在140/90 mmHg以下的T2DM患者143例,以cIMT 0.9mm为标准将其分为cIMT<0.9 mm(IMT正常组)和cIMT≥0.9mm( IMT增厚组),比较两组间年龄、病程、早期肾病( MAU)所占比例、GFR及各项生化指标的差异. 结果 IMT增厚组的年龄、糖尿病病程、MAU所占比例明显高于IMT正常组,而GFR则明显低于IMT正常组(P<0.05).多元逐步回归分析显示cIMT与年龄、糖尿病病程呈正相关,而与GFR呈负相关. 结论 随着动脉硬化的不断进展,GFR呈不断下降趋势且独立于传统的心血管危险因素参与早期动脉硬化的发生与发展.

  19. 厄贝沙坦对早期糖尿病肾病患者颈动脉内膜中层厚度及临床生化指标的影响%Effects of Irbesartan on Carotid Intima-media Thickness and Clinical Biochemical Indexes of Patients with Early Diabetic Nephropath y

    Institute of Scientific and Technical Information of China (English)

    郑锦桥; 饶惠平; 黄瑞文

    2015-01-01

    目的:观察厄贝沙坦对早期糖尿病肾病(DN)患者临床血生化指标及颈动脉内膜中层厚度(IMT)的影响。方法:将86例血压正常的早期DN患者用随机数字表法分为厄贝沙坦组(E组)和培哚普利组(P组),各43例。两组均给予饮食控制、降低血糖等常规治疗,P组:培哚普利片4 mg/d、1次/d;E组:厄贝沙坦片0.15 g/d、1次/d,疗程为48周。比较两组治疗前后尿清蛋白排泄率(UAER)、血浆Hcy水平及颈动脉IM T等的变化。结果:P组、E组治疗后的UAER、血浆Hcy、SBP、DBP及颈动脉IMT较治疗前均显著降低(P<0.05);Pearson相关分析结果显示IMT值与UAER、Hcy呈正相关(P<0.01)。结论:早期DN患者Hcy、UAER与颈动脉IMT之间呈正相关,糖尿病微血管病变与大血管并发症关系密切。厄贝沙坦能降低早期DN患者的SBP、DBP、UAER、Hcy、IMT,对于延缓早期DN患者主要并发症具有现实意义。%Objective:To Observe the effects of irbesartan on carotid intima-media thickness and clinical biochemical indexes of patients with early diabetic nephropathy.Method:86 patients with early DN normotensive were randomly divided into irbesartan group(E group) and perindopril group(P group),43 cases in each group.Both groups were given conventional treatment such as diet control and lower blood sugar.Patients in the P group were given perindopril tablets 4 mg/d,1 time/d, while the E group was given irbesartan tablets 0.15 g/d,1 time/d,the treatment continued for 48 weeks.Urinary albumin excretion rate(UAER),changes in plasma Hcy level and carotid IMT before and after treatment were compared between the two groups. Result:After treatment,the UAER,plasma Hcy level、SBP、DBP and carotid IMT of the two groups were significantly lower than before treatment(P<0.05).Carotid IMT had a positive correlation with UAER and Hcy(P<0.01).Conclusion:UAER and Hcy of patients with early diabetic have a

  20. Сharacteristics of flexible elastic properties of the carotid arteries in women with arterial hypertension

    OpenAIRE

    Коval О.A.; Zubko I.M.

    2013-01-01

    The article presents the results of study of the features of the carotid wall structure using ultrasound scanning with differential measurement of intima and media thickness, as well as characteristics of arterial elasticity in women with hypertension without comorbidities. It is shown that in women with hypertension vascular remodeling occurs mainly in the form of thickening of the intima-media due to increase in the media layer and is associated with remodeling of the left heart. Carotid re...

  1. Comparison of Different Edge Detections and Noise Reduction on Ultrasound Images of Carotid and Brachial Arteries Using a Speckle Reducing Anisotropic Diffusion Filter

    OpenAIRE

    Rafati, Mehravar; Arabfard, Masoud; Rafati-Rahimzadeh, Mehrdad

    2014-01-01

    Background: Common carotid artery (CCA) ultrasound with measurement of intima-media thickness (IMT) is a safe and noninvasive technique for assessing subclinical atherosclerosis and determining cardiovascular risks. Moreover, the pattern of wall thickening in the brachial artery (BA) is rather diffuse compared to the carotid artery and may be a more sensitive indicator of long-term systemic exposure to risk factors. Therefore noninvasive evaluation of mechanical parameters changes of both art...

  2. Comparison of semi-automated and manual measurements of carotid intima-media thickening.

    LENUS (Irish Health Repository)

    Mac Ananey, Oscar

    2014-01-01

    Carotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects (n = 126) were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used to compare both methodologies. The ICC of manual (0.547 ± 0.095 mm) and automated (0.524 ± 0.068 mm) methods was R = 0.74 and an absolute mean bias ± SD of 0.023 ± 0.052 mm was observed. Interobserver and intraobserver ICC were greater for automated (R = 0.94 and 0.99) compared to manual (R = 0.72 and 0.88) methods. Although not considered to be clinically significant, manual measurements yielded higher values compared to automated measurements. Automated measurements were more reproducible and showed lower interobserver variation compared to manual measurements. These results offer important considerations for large epidemiological studies.

  3. 血清淀粉样蛋白A与2型糖尿病肾病患者颈动脉内膜中层厚度的相关性研究%Association of serum amyloid A with carotid intima-media thickness in type 2 diabetes patients accompanied with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    郭世喜

    2014-01-01

    Objectives To investigate change of serum amyloid A (SAA) levels in type 2 diabetic patients (T2DM) accompanied with diabetic nephropathy (DN) and association of SAA with carotid intima-media thickness (CIMT).Methods 75 patients with newly diagnosed T2DM were divided into simple T2DM group (SDM group,39 cases),and early diabetic nephropathy group (EDN group,36 cases),and meanwhile choose 35 patients of health examination as control group(NC group).SAA levels were assayed by ELISA technique,and related parameters such as creatinine (Cr),blood urea nitrogen(BUN),blood glucose and lipids,HOMA-insulin resistance index (HOMA-IR),high-sensitivity C-reactive protein (hsC-RP),CIMT were measured.The relationship between SAA levels,CIMT,other metabolic parameters was also analyzed.Results SAA levels in patients with SDM and EDA groups were significantly increased compared with that of NC group (7.98 ±0.63 vs.6.09 ±0.72 vs.2.75 ± 0.30 mg/L,respectively,P < 0.05 orP < 0.01).CIMT value in patients with SDM and EDA groups was significantly increased compared with that of NC group (1.07 ±0.13vs.0.86 ±0.22 vs.0.72 ±0.13mm,respectively,P <0.05 or P <0.01).SAA level in DN group was positively related to Hs-CRP,interleukin-6 (IL-6),FBG,HOMA-IR,CIMT,quantitative carotid plaque and urinary albumin excretion rate (UAER),and negatively with high-density lipoprotein cholesterols (HDL-C) (P <0.05 orP <0.01).SAA levels in patients with two or more plaques bilaterally were significantly increased compared with that of only one or less plaque in EDA group (P < 0.01).SAA levels in EDA group was positively related to thickness of plaque (r =0.409,P < 0.05).Multiple regression analysis showed that UAER,HOMA-IR,CIMT and Hs-CRP were the independent risk factors of SAA in DN patients.Conclusions Measurement of SAA combined with CIMT can infer effect of SAA on atherosclerosis,evaluate the lesion of early diabetic nephropathy overall,which suggested that early intervention for

  4. 中老年人糖化血红蛋白水平与颈动脉内膜-中层厚度的相关性研究:广州生物库心血管疾病亚队列%Effects of plasma levels of glycosylated hemoglobin A1c on carotid intima media thickness in the elderly Chinese people:the cardiovascular disease subgroup of Guangzhou Biobank Cohort Study

    Institute of Scientific and Technical Information of China (English)

    林洁明; 林大庆; 江朝强; 徐琳; 刘斌; 岳晓军; 靳雅丽; Thomas GN

    2010-01-01

    Objective To investigate the effect of glycosylated hemoglobin A1c(HbA1c) on carotid atheresclerosis in relatively healthy elderly Chinese people.Methods A total of 1863 relatively healthy Chinese people(≥50 years old)were randomized enrolled from the Guangzhou Biobank Cohort Study(GBCS).Personal general historiy Was collected before the study in all object.The blood pressure,fasting glucose,lipids,HbA1c and common carotid artery intima-median thickness(CCA-IMT)were measured respectively.After adjustment relevant confounding factors,analysis of convariance was used for continuous variable analysis.Results (1)Ater adjusting for age,sex and fasting glucose,mean CCA-IMT were increased significantly with the increase of HbA1c level in all participant(P=0.005).The results of linear regression models show that, HbA1c levels was positively associated with mean CCA-IMT after adjusting for age,sex,smoking,physical activity,waist circumference,systolic and diastolic blood pressure,triglyceride,hish-density,low-density lipoprotein cholesterol and fasting glucose(regression coefficient t=0.014,P=0.03).Compared to the optimal group(HbA1c7.5%)were 1.62(1.10,2.38)and 1.76(0.86,3.63)respectively(P for trend=0.01).Conclusions Increasing HbA1c level is an independent risk factor for carotid athemsclerosis;that HbA1c-lowering treatment may be an important means for preventing the progression of carotid atherosclerosis.%目的 探讨相对健康的中老年人血中糖化血红蛋白(HbAlc)含量对颈动脉硬化的影响.方法 从广州生物库队列中单纯随机抽样收集1863名年龄≥50岁的广州市居民的个人资料,问卷调查其病史、体格检查及测定血清空腹血糖、血脂、HbA1c的含量并应用彩色多普勒超声测量颈总动脉内膜-中层厚度(intima media thickness,IMT).在调整相关混染因素后,应用协方差分析进行连续变量分析.结果 (1)在调整年龄、性别和空腹血糖等因素后,平均颈总动脉IMT随HbA1c

  5. Cocoa intake and arterial stiffness in subjects with cardiovascular risk factors

    Directory of Open Access Journals (Sweden)

    Recio-Rodríguez José

    2012-02-01

    Full Text Available Abstract Background To analyze the relationship of cocoa intake to central and peripheral blood pressure, arterial stiffness, and carotid intima-media thickness in subjects with some cardiovascular risk factor. Findings Design: A cross-sectional study of 351 subjects (mean age 54.76 years, 62.4% males. Measurements: Intake of cocoa and other foods using a food frequency questionnaire, central and peripheral (ambulatory and office blood pressure, central and peripheral augmentation index, pulse wave velocity, ambulatory arterial stiffness index, carotid intima-media thickness, and ankle-brachial index. Results: Higher pulse wave velocity and greater cardiovascular risk were found in non-cocoa consumers as compared to high consumers (p Conclusions In subjects with some cardiovascular risk factors, cocoa consumption does not imply improvement in the arterial stiffness values. Trial Registration Clinical Trials.gov Identifier: NCT01325064.

  6. The Effect of Rosuvastatin Combined with Perindopril on LDL-C/HDL-C and Carotid Intima Media Thickness in Hypertension Patients%瑞舒伐他汀联合培哚普利对高血压患者 LDL-C 与 HDL-C 比值和颈动脉内膜中层厚度的影响

    Institute of Scientific and Technical Information of China (English)

    陆洋; 张跃明; 颜永进

    2014-01-01

    目的:探讨瑞舒伐他汀联合培哚普利对高血压患者低密度脂蛋白胆固醇( LDL-C )/高密度脂蛋白胆固醇( HDL-C)和颈动脉内膜中层厚度( IMT)的影响及二者之间的相关性。方法:入选初诊高血压伴高LDL-C血症患者126例,在给予基础降压治疗基础上随机分为治疗组63例(培哚普利+瑞舒伐他汀治疗)和对照组63例(瑞舒伐他汀治疗)。比较治疗前和治疗3周后血压、LDL-C、HDL-C、LDL-C/HDL-C和IMT变化。结果:治疗后治疗组收缩压、舒张压和平均动脉压均较对照组下降明显(P=0.012,P=0.029,P=0.037)。两组患者治疗前后LDL-C、HDL-C比较均没有统计学差异(P均>0.05)。但治疗组治疗后LDL-C/HDL-C下降较对照组明显(P=0.007),平均IMT和最大IMT均明显小于照组( P=0.001,P<0.001)。治疗前后LDL-C/HDL-C差值与平均IMT差值呈正相关( P<0.001,r=0.742)。结论:瑞舒伐他汀联合培哚普利可以逆转高血压伴高LDL-C血症患者颈动脉内膜斑块,二者联合使用对减少心脑血管疾病的发生有重要意义。%Objective:To investigate the efficacy of rosuvastatin combined with perindopril on LDL-C/HDL-C and carotid intima media thickness ( IMT) in hypertension patients, and the correlation between LDL-C/HDL-C and IMT.Method:A total of 126 high LDL-C patients with newly diagnosed hypertension were randomized to treatment group (n=63) and control group (n=63) after enrolled.On the basis of rou-tine antihypertensive therapy , treatment group received rosuvastatin treatment with the addition of perindopril and control group received rosuvastatin treatment only .Blood pressure , LDL-C, HDL-C, LDL-C/HDL-C and IMT were collected before and after 3 weeks treatment .Result:Systolic blood pressure ( SBP ) , dystolic blood pressure ( DBP ) , and mean blood pressure in treatment group were lower than that in control group af

  7. 中青年男性体脂分布与颈动脉内膜中层厚度的相关研究%The study of relationship between body fat distribution and carotid intima-media thickness in young and middle-aged men

    Institute of Scientific and Technical Information of China (English)

    马春朋; 刘兰祥; 杨蕾; 刘晓丽; 王锐; 尹福在; 陆强

    2013-01-01

    Objective To evaluate the relationship between fat distribution and carotid intima-media thickness (CIMT) in young and middle-aged men.Methods Five hundred and one men aged 20-50 years who took physical examination in the first hospital of qinhuangdao were selected.The abdominal obesity group included 299 cases with waist circumference ≥90 cm,and the normol waist circumference group included 202 cases with waist circumference <90 cm.Height,weight and waist circumference were measured and body mass index was calculated.Fasting insulin (FINS) and fasting plasma glucose (FPG) were detected,and homeostasis model assay insulin resistance index (HOMA-IR) was calculated.Total body fat mass (BF),body muscle mass (BM),truncal fat mass (TrF),upper limb fat mass (UF),limb fat mass (LF) were measured by dual energy X-ray absorptiometry (DEXA).BF%(=BF/W) and TrF/BF were calculated.CIMT was detected with color ultrasound.Results (1) The abdominal obesity group showed increased levels of BF%,TrF/BF,BF,BM,TrF,UF,LF,body mass index,waist circumference,CIMT and HOMA-IR,compared with normol waist circumference group (all P <0.05).(2) In Pearson correlation analysis,CIMT had positive correlation with BF%,TrF/BF,BF,BM,TrF,UF,LF,body mass index and waist circumference (R=0.443,0.481,0.429,0.377,0.472,0.376,0.304,all P <0.05).(3)In Pearson correlation analysis,HOMA-IR had positive correlation with BF%,TrF/BF,BF,BM,TrF,UF,LF,body mass index,waist circumference(R =0.510,0.441,0.576,0.502,0.528,0.526,0.577,0.384,0.639,all P<0.05).HOMA-IR had positive correlation with CIMT (R =0.416,P <0.05).(4)In multiple regression analyses,TrF/BF and body mass index were the independent risk factors of CIMT.Conclusion Fat distribution was closely related with CIMT and insulin resistance in young and middle-aged men.To prevent carotid atherosclerosis and cardiovascular diseases,exercise should be recommended and abdominal obesity should be avoided.%目的 探讨中青年男性体

  8. Serum Carotenoids Reduce Progression of Early Atherosclerosis in the Carotid Artery Wall among Eastern Finnish Men

    OpenAIRE

    Jouni Karppi; Sudhir Kurl; Kimmo Ronkainen; Jussi Kauhanen; Laukkanen, Jari A.

    2013-01-01

    BACKGROUND: Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. We assessed the association between atherosclerotic progression, measured by intima-media thickness of the common carotid artery wall, and serum levels of carotenoids. METHODS: We studied the effect of carotenoids on progression of early atherosclerosis in a population-based study. The association between conce...

  9. Possibility of non-invasive blood pressure estimation by measurements of force and arteries diameter

    OpenAIRE

    Veye, Florent; Mestre, Sandrine; Perez-Martin, Antonia; Triboulet, Jean

    2014-01-01

    International audience Ultrasound examination is the first line procedure for the diagnosis and follow-up of cardiovascular diseases. Instrumenting an ultrasound probe with a force sensor may improve the non-invasive measurement of arterial biomechanical parameters (diameter, pulsatility, intima-media thickness and flow-dependent dilation) by measuring and controlling the force exerted by the sonographer. We present here the results obtained with this approach coupled with image processing...

  10. Carotid artery wall thickness: comparison between sonography and multi-detector row CT angiography

    Energy Technology Data Exchange (ETDEWEB)

    Saba, Luca [University of Cagliari, Department of Radiology, Policlinico Universitario, Cagliari (Italy); Sanfilippo, Roberto; Montisci, Roberto [Policlinico Universitario, Department of Vascular Surgery, Cagliari (Italy); Mallarini, Giorgio [University of Cagliari, Department of Radiology, Policlinico Universitario, Cagliari (Italy); Ospedale San Giovanni di Dio, Institute of Radiology, Cagliari (Italy)

    2010-02-15

    Prospective studies have shown that an increased thickness of the carotid wall is a significant predictor of coronary and cerebrovascular complications. Our purpose was to assess the agreement between multi-detector row computed tomography (CT) angiography (MDCTA) and colour Doppler ultrasound (CD-US) in measuring carotid artery wall thickness (CAWT) and the intima-media thickness (IMT). Altogether, 97 subjects (age range 64-84 years) were prospectively analysed using a four-detector row CT and a sonographic scanner. In total, 46 subjects had shown cerebral ischaemic symptoms. CAWT and IMT were measured in each patient using MDCTA and CD-US (by applying a digital calliper), respectively. Continuous data were described as the mean value {+-} standard deviation and were compared using the Mann-Whitney U test. A p value <0.05 was considered significant. Bland-Altman statistics was employed to measure the agreement between MDCTA and CD-US. CAWT ranged from 0.5 to 1.53 mm, with a mean value of 0.9072 mm. IMT ranged from 0.46 to 1.5 mm, with a mean value of 0.8839 mm. By analysing the Bland-Altman plot, we observed an excellent agreement between CD-US and MDCTA with a bias between methods of 0.023 {+-} 0.0424 mm. A limit of agreement from -0.06 to 0.106 was recorded. Correlation coefficient r was 0.9855 (95% confidence interval 0.9808-0.989). Mann-Whitney U test indicated a p value of 0.377. Obtained results indicated a significant agreement between MDCTA and CD-US in the measurement of CAWT and IMT. (orig.)

  11. Carotid artery wall thickness: comparison between sonography and multi-detector row CT angiography

    International Nuclear Information System (INIS)

    Prospective studies have shown that an increased thickness of the carotid wall is a significant predictor of coronary and cerebrovascular complications. Our purpose was to assess the agreement between multi-detector row computed tomography (CT) angiography (MDCTA) and colour Doppler ultrasound (CD-US) in measuring carotid artery wall thickness (CAWT) and the intima-media thickness (IMT). Altogether, 97 subjects (age range 64-84 years) were prospectively analysed using a four-detector row CT and a sonographic scanner. In total, 46 subjects had shown cerebral ischaemic symptoms. CAWT and IMT were measured in each patient using MDCTA and CD-US (by applying a digital calliper), respectively. Continuous data were described as the mean value ± standard deviation and were compared using the Mann-Whitney U test. A p value <0.05 was considered significant. Bland-Altman statistics was employed to measure the agreement between MDCTA and CD-US. CAWT ranged from 0.5 to 1.53 mm, with a mean value of 0.9072 mm. IMT ranged from 0.46 to 1.5 mm, with a mean value of 0.8839 mm. By analysing the Bland-Altman plot, we observed an excellent agreement between CD-US and MDCTA with a bias between methods of 0.023 ± 0.0424 mm. A limit of agreement from -0.06 to 0.106 was recorded. Correlation coefficient r was 0.9855 (95% confidence interval 0.9808-0.989). Mann-Whitney U test indicated a p value of 0.377. Obtained results indicated a significant agreement between MDCTA and CD-US in the measurement of CAWT and IMT. (orig.)

  12. Assessment of carotid diameter and wall thickness in ultrasound images using active contours improved by a multiresolution technique

    Science.gov (United States)

    Gutierrez, Marco A.; Pilon, Paulo E.; Lage, Silvia G.; Kopel, Liliane; Carvalho, Ricardo T.; Furuie, Sergio S.

    2002-04-01

    Carotid vessel ultrasound imaging is a reliable non-invasive technique to measure the arterial morphology. Vessel diameter, intima-media thickness (IMT) of the far wall and plaque presence can be reliably determined using B-mode ultrasound. In this paper we describe a semi-automatic approach to measure artery diameter and IMT based on an active contour technique improved by a multiresolution analysis. The operator selects a region-of-interest (ROI) in a series of carotid images obtained from B-mode ultrasound. This set of images is convolved with the corresponding partial derivatives of the Gaussian filter. The filter response is used to compute a 2D gradient magnitude image in order to refine the vessel's boundaries. Using an active contour technique the vessel's border is determined automatically. The near wall media-adventitia (NWMA), far wall media-adventitia (FWMA) and far wall lumen-intima (FWLI) borders are obtained by a least-square fitting of the active contours result. The distance between NWMA and FWLI (vessel diameter) and between FWLI and FWMA (far wall intima-media thickness) are obtained for all images and the mean value is computed during systole and diastole. The proposed method is a reliable and reproducible way of assessing the vessel diameter and far wall intima-media thickness of the carotid artery.

  13. A Data Mining Approach for Cardiovascular Disease Diagnosis Using Heart Rate Variability and Images of Carotid Arteries

    OpenAIRE

    Hyeongsoo Kim; Musa Ibrahim M. Ishag; Minghao Piao; Taeil Kwon; Keun Ho Ryu

    2016-01-01

    In this paper, we proposed not only an extraction methodology of multiple feature vectors from ultrasound images for carotid arteries (CAs) and heart rate variability (HRV) of electrocardiogram signal, but also a suitable and reliable prediction model useful in the diagnosis of cardiovascular disease (CVD). For inventing the multiple feature vectors, we extract a candidate feature vector through image processing and measurement of the thickness of carotid intima-media (IMT). As a complementar...

  14. ULTRASONOGRAPHIC ASSESSMENT OF COMMON CAROTID ARTERY ATHEROSCLEROSIS IN PATIENTS OF RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    Jayakumar

    2015-02-01

    Full Text Available BACKGROUND & OBJECTIVES: Patients with Rheumatoid Arthritis (R.A. have a marked increase in Carotid Atherosclerosis independent of traditional risk factors like family history of myocardial infarction in first degree male relatives younger than 55 years of age or first degree female relatives younger than 65 years of age, smoking, hypertension (D efined as blood pressure of 140/90 mm hg or higher, diabetes mellitus and fasting serum cholesterol levels including age. Chronic inflammation and possibly disease severity and duration are atherogenic in Rheumatoid Arthritis patients. Preclinical disease may also be identified by using ultrasonography to determine carotid intimal - media thickness, an indirect measure of atherosclerosis. The common carotid artery Intima media thickness in Rheumatoid Arthritis patients is positively associated with disease duration, Early Rheumatoid Arthritis (D uration less or = 1 year is associated with lesser Intima media thickness than was Rheumatoid Arthritis of longer duration. Increased carotid artery Intima media thickness and the presence of carotid plaque are associated with markers of systemic inflammation in patients with Rheumatoid Arthritis and in healthy subjects. OBJECTIVE OF THE STUDY: To determine preclinical atherosclerosis occurring prematurely in patients of Rheumatoid Arthritis by ultrasonograhic measurement Common Carotid Artery Intima media thickness and to evaluate the risk factors associated with arterial intima media thickness in patient of Rheumatoid Arthritis. RESULTS: In RA patients, common carotid artery IMT was significantly higher when compared to healthy controls (0.65 ± 0.06 v/s 0.57 ± 0.049 and was significantly associated with the duration of RA, swollen joint count and erosive changes on hand x - ray independently of other confounding variables. CONCLUSION: Patients with rheumatoid arthritis have a marked increase in carotid atherosclerosis independent of traditional risk factors

  15. 维格列汀联合二甲双胍治疗对2型糖尿病合并心脑血管疾病 IMT、血清 APN 及 Hcy 水平的影响%Effects of Vildagliptin Combined with Metformin on Carotid Intima-Media Thickness and Serum Adiponectin and Homocysteine Levels in Type 2 Diabetes Mellitus Patients with Cardio-Cerebral Vascular Disease

    Institute of Scientific and Technical Information of China (English)

    郑仲萍; 田峰; 郑志刚; 于敏

    2015-01-01

    ABSTRACT:Objective To observe the effects of vildagliptin combined with metformin on carot-id intima-media thickness (IMT)and serum adiponectin (APN)and homocysteine (Hcy)levels in type 2 diabetes mellitus (T2DM)patients with cardio-cerebral vascular disease (CCVD),and to investigate the risk factors for CCVD in patient with T2DM.Methods One hundred and fifty newly diagnosed T2DM patients with CCVD were randomly treated with vildagliptin (group A, n=50),metformin (group B,n=50)or their combination (group C,n=50).The control of blood glucose and improvement in IMT and serum APN and Hcy levels were assessed after treatment for 3 months.Results The IMT and Hcy levels decreased but APN levels increased after treat-ment for 3 months in both group A and group C (P <0.05).Compared with group A or B,the IMT and levels of Hcy and APN were significantly improved in group C (P <0.05).The IMT was positively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.356,P = 0.013),low density lipoprotein (LDL)(r = 0.363,P = 0.009)and Hcy (r =0.756,P =0.022),but negatively correlated with high density lipoprotein (HDL)(r=-0.461, P =0.001)and APN (r=-0.482,P =0.000).Conclusion The increase in HOMA-IR,LDL and Hcy and decrease in HDL and APN are risk factors for IMT thickening in T2DM patients.The combined treatment with vildagliptin and metformin can effectively reduce IMT and Hcy levels and elevate APN contents in T2DM patients with CCVD.%目的:观察维格列汀联合二甲双胍治疗对2型糖尿病合并心脑血管疾病颈动脉内膜中层厚度(carotid inti-ma-media thickness,IMT)、血清脂联素(adiponectin,APN)和同型半胱氨酸(homocysteine,Hcy)水平的影响,探讨2型糖尿病并发心脑血管疾病的危险因素。方法将150例初诊2型糖尿病合并心脑血管疾病患者随机分为3组:A 组50例采用维格列汀治疗,B 组50例采用二甲双胍治疗,C 组50例采用维格列汀联

  16. Frequency of coronary artery stenosis in patients with asymptomatic familial hypercholesterolemia and its association with carotid intimal thickness and cardio-ankle vascular index

    Directory of Open Access Journals (Sweden)

    Suzuki M

    2016-06-01

    Full Text Available Masayo Suzuki,1 Mao Takahashi,1 Takuo Iizuka,1 Hitoshi Terada,2 Hirohumi Noike,1 Kohji Shirai3 1Cardiovascular Center, Internal Medicine, 2Department of Radiology, 3Department of Vascular Function, Sakura Hospital, Medical Center, Toho University, Sakura City, Chiba Prefecture, Japan Background: Familial hypercholesterolemia (FH is associated with premature coronary arterial disease. We aimed to determine the incidence of coronary artery stenosis (CAS in asymptomatic FH patients using coronary computed tomography angiography (CCTA. To investigate the association between CAS and atherosclerosis of carotid arteries, we performed ultrasonography to measure the mean intima-media thickness (IMT, maximum IMT, and plaque score. We also aimed to examine the significance of the cardio-ankle vascular index (CAVI and its association with the incidence of CAS in asymptomatic FH patients. Patients and methods: We enrolled consecutively, 31 FH patients without symptoms of coronary artery disease. Based on the CCTA findings, we divided the patients into two groups, those with and without CAS, and compared various parameters and risk factors of the two groups. Results: Of 31 FH patients, seven patients (22.6% had CAS. The proportion of male patients and mean low-density lipoprotein-cholesterol level were higher in patients with CAS than in those without CAS (P<0.05. All carotid ultrasonography parameters (ie, mean IMT, maximum IMT, and plaque score were significantly higher in patients with CAS than in those without CAS (P<0.01, whereas no significant difference was found in CAVI between the two groups. Conclusion: CAS was identified in >22.6% of the asymptomatic FH patients. Patients with CAS tended to have enhanced levels of carotid plaque markers, but no increase was noted in CAVI. FH patients should be continuously monitored using CCTA and ultrasonography. Keywords: CAVI, coronary artery stenosis, heterozygous familial hypercholesterolemia, CCTA, ultrasound

  17. Initial exploration of early carotid artery endothelial dysfunction in type 2 diabetes mellitus patients evaluated by ultrasound radio-frequency technique

    Institute of Scientific and Technical Information of China (English)

    LI Miao-shan; WANG Man-li; WU Li-sang; ZHU Wu; WU Yan-ping

    2016-01-01

    Background The early endothelial dysfunction of carotid artery in patients with type 2 diabetes mellitus (T2DM) has been recognized.However,the feasibility and significance of carotid artery endothelial dysfunction detected by ultrasound radio-frequency technology has been seldom studied.Methods The 2D ultrasound images of the bilateral common carotid arteries from 112 cases of T2DM patients and 50 cases of normal subjects in our hospital were collected to measure intima-media thickness means (IMTm),end-systolic inner diameter (Ds),end-diastolic inner diameter (Dd),resistance index (RI),pulse index (PI),and the systole/diastole ratio (S/D).We also observed the variation of the intima-media thickness (IMT) as well as the elasticity indexes of the common carotid artery,such as the compliance coefficient (CC),elasticity coefficient (β),pulse wave velocity (PWV) and augmentation index (AIx) through instruments with built-in ultrasound radio-frequency techniques,including quantitative intima-media thickness (QIMT) and quantitative analysis of arterial stiffness (QAS).The differences of the above-mentioned parameters between the two groups were analyzed.Results There were no statistically significant differences in IMTm,Ds,Dd,RI,PI and S/D raito of the common carotid arteries between group T2DM and the normal group (P > 0.01).The β,PWV and AIx in group T2DM were remarkably higher than those in the control group,with CC value being significantly lower than the later (P < 0.01 or 0.05).Conclusion Ultrasound radio-frequency technique offers earlier and more effective evaluation of carotid artery endothelial dysfunction in T2DM patients when compared with conventional 2D ultrasound,establishing imaging foundation for the early prevention and treatment of cardio-cerebrovascular complications in T2DM patients.

  18. 痛风患者颈动脉内膜-中膜厚度与UA、CRP水平的关系探讨%RELATIONSHIP BETWEEN THE INTIMA-MEDIA THICKNESS OF CAROTID,BLOOD URIC ACID LEVEL AND C-REACTIVE PROTEIN IN PATIENTS WITH GOUT

    Institute of Scientific and Technical Information of China (English)

    欧阳清; 于健; 刘健; 陈辉; 周燕; 祖颖

    2011-01-01

    [目的]通过研究痛风患者颈动脉内膜-中膜厚度(IMT)与血尿酸(UA)、C 反应蛋白(CRP)的关系,研究 UA、CRP 在痛风患者动脉粥样硬化的作用.[方法]60 例痛风患者,正常对照组 40 例,分析 2 组人群空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血尿酸、C 反应蛋白,测定颈动脉内膜-中膜厚度,同时计算体重指数(BMI).[结果]痛风患者组与正常组比较:年龄、FPG、TG、HDL-C、BMI 无统计学差异(均P>0.05),UA、CRP、IMT 有统计学差异(P<0.01或P<0.05).痛风患者 IMT 与年龄、TC、TG、LDL-c、UA、BMI、CRP呈正相关(P<0.05或 P<0.01).[结论]UA、CRP 水平升高与痛风患者动脉粥样硬化(AS)关系密切,关注痛风患者 UA、CRP 水平的升高对临床具有重要意义.%[Objective] To investigate the relationship between the inlima-media thickness (IMT) of carotid, blood uric acid level (UA) and C-reactive protein (CRP) in patients with Gout, and to investigate UA and CRP affection on atheroscle rosis in those patients. [Methods] We collected 60 patients with Gout and 40 patients with the contral, measured fasting plas ma glucose (FPG), total cholesterol (TC), triglyceride (TG) , high density lipoprotein cholesterol (HDL-C) , low density lipoprotein cholesterol (LDL-C), UA and CRP in those two group patients, detected the IMT of carotid and calculated body mass index (BMI). [Results] The levels of UA, CRP and IMT in patients with Gout were significantly higher than those con trol subjects (P < 0.05 or P < 0.01). But the age, FPG, TG, HDL-C and BMI had no significantly difference in those two group patients (P> 0.05). The IMT had positively person correlation to age, TC, TG, LDL-C, UA, BMI and CRP (P<0.05 or P < 0.01) in the patients with gout. [Conclusion] The high levels of UA and CRP in blood were related to development pro gression of atherosclerotic disease in patients with Gout. It is

  19. Determinants of Functional and Structural Properties of Large Arteries in Healthy Individuals

    Energy Technology Data Exchange (ETDEWEB)

    Tolezani, Elaine Cristina; Costa-Hong, Valéria, E-mail: hong.valeria@gmail.com; Correia, Gustavo; Mansur, Alfredo José; Drager, Luciano Ferreira; Bortolotto, Luiz Aparecido [Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-11-15

    Changes in the properties of large arteries correlate with higher cardiovascular risk. Recent guidelines have included the assessment of those properties to detect subclinical disease. Establishing reference values for the assessment methods as well as determinants of the arterial parameters and their correlations in healthy individuals is important to stratify patients. To assess, in healthy adults, the distribution of the values of pulse wave velocity, diameter, intima-media thickness and relative distensibility of the carotid artery, in addition to assessing the demographic and clinical determinants of those parameters and their correlations. This study evaluated 210 individuals (54% women; mean age, 44 ± 13 years) with no evidence of cardiovascular disease. The carotid-femoral pulse wave velocity was measured with a Complior{sup ®} device. The functional and structural properties of the carotid artery were assessed by using radiofrequency ultrasound. The means of the following parameters were: pulse wave velocity, 8.7 ± 1.5 m/s; diameter, 6,707.9 ± 861.6 μm; intima-media thickness, 601 ± 131 μm; relative distensibility, 5.3 ± 2.1%. No significant difference related to sex or ethnicity was observed. On multiple linear logistic regression, the factors independently related to the vascular parameters were: pulse wave velocity, to age (p < 0.01) and triglycerides (p = 0.02); intima-media thickness, to age (p < 0.01); diameter, to creatinine (p = 0.03) and age (p = 0.02); relative distensibility, to age (p < 0.01) and systolic and diastolic blood pressures (p = 0.02 and p = 0.01, respectively). Pulse wave velocity showed a positive correlation with intima media thickness (p < 0.01) and with relative distensibility (p < 0.01), while diameter showed a positive correlation with distensibility (p = 0.03). In healthy individuals, age was the major factor related to aortic stiffness, while age and diastolic blood pressure related to the carotid functional measure

  20. Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia

    NARCIS (Netherlands)

    Wiria, A.E.; Wammes, L.J.; Hamid, F.; Dekkers, O.M.; Prasetyani, M.A.; May, L.; Kaisar, M.M.; Verweij, J.J.; Tamsma, J.T.; Partono, F.; Sartono, E.; Supali, T.; Yazdanbakhsh, M.; Smit, J.W.A.

    2013-01-01

    OBJECTIVE: To examine the association between helminth infections and atherosclerosis. BACKGROUND: Chronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis. METHODS: A cross-sectional study was perf

  1. [Effect of pravastatine plus ezetimibe on carotid intima media thickness in patients with lupus erythematosus].

    Science.gov (United States)

    Vera-Lastra, Olga Lidia; Olvera-Acevedo, Arturo; Hernández, Claudia; Medina, Gabriela; Carrillo-González, Ana Laura; Ángeles-Garay, Ulises; Peralta-Amaro, Ana Lilia; Jara, Luis

    2015-01-01

    Introducción: Los pacientes con lupus eritematoso sistémico (LES) cursan con ateroesclerosis acelerada que puede ser evaluada mediante el grosor íntima-media carotídea (IMC). El uso de hipolipemiantes debe ser parte de su tratamiento. El objetivo de este estudio fue determinar el efecto de la terapia con pravastatina más ezetimibe en el grosor IMC en pacientes con LES.Métodos: estudio prospectivo, longitudinal, cuasi-experimental. De 60 paciente con LES a quienes se le realizó ultrasonido carotídeo, de los cuales se eligieron a 22 con grosor IMC > 0.7 mm y se les administró pravastatina más ezetimibe durante seis meses y posteriormente se determinó el grosor IMC. Se les determinó colesterol total (CT), colesterol HDL (c-HDL), colesterol LDL (c-LDL), triglicéridos, proteína C-reactiva (PCR), pruebas de funcionamiento hepático, enzimas musculares y glucosa basales y posterior al tratamiento. Análisis estadístico: estadística descriptiva y prueba de Wilcoxon.Resultados: se incluyeron 22 mujeres con edad 42 ± 6.3 años y evolución promedio 7.5± 6.6 años, de las cuales concluyeron el estudio 18 pacientes. El grosor IMC derecha basal fue de 0.829 ± 0.1448 frente a final 0.688 ± 0.1453, p < 0.003; el izquierdo 0.820±0.1312 frente a 0.724±0.1348, p < 0.004. El CT 208 mg/dl frente a 168 mg/dl, y el c-LDL 125 mg/dl frente a 72 mg/dl, p = 0.0004. Niveles de PCR 3.12 frente a 2.25 p = 0.004.Conclusiones: el tratamiento con pravastatina más ezetimibe disminuye el grosor IMC con mejoría en las concentraciones de colesterol total, colesterol LDL y niveles de PCR, así como buena tolerancia.

  2. Relationship between Carotid Intima Media Thickness and Helminth Infections on Flores Island, Indonesia

    OpenAIRE

    Wiria, A.E.; Wammes, L. J.; Hamid, F.; Dekkers, O. M.; Prasetyani, M.A.; May, L; Kaisar, M.M.; Verweij, J. J.; Tamsma, J. T.; F. Partono; Sartono, E.; Supali, T.; Yazdanbakhsh, M.; Smit, J. W. A.

    2013-01-01

    Objective To examine the association between helminth infections and atherosclerosis. Background Chronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis. Methods A cross-sectional study was performed in Flores, Indonesia, an area highly endemic for soil-transmitted helminths (STH). Stool samples from 675 participants aged 18???80 years were collected and screened for Trichur...

  3. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

    DEFF Research Database (Denmark)

    Dullaart, Robin P F; Plomgaard, Peter; de Vries, Rindert;

    2009-01-01

    BACKGROUND: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subje...

  4. Carotid intima-media thickness in HIV patients treated with antiretroviral therapy

    DEFF Research Database (Denmark)

    Lebech, Anne-Mette; Wiinberg, Niels; Kristoffersen, Ulrik Sloth;

    2007-01-01

    no correlation was found with total cholesterol or LDL cholesterol. CONCLUSIONS: In non-smoking HIV patients receiving ART no sign of accelerated atherosclerosis was found as assessed by IMT even not in hypercholesterolaemic HIV patients. IMT correlated with HDL cholesterol but not with LDL cholesterol. Based...... on these observations, one could speculate whether selective lowering of LDL cholesterol will be successful in reducing cardiovascular risk in non-smoking HIV patients....

  5. Segmentace ultrazvukových snímků za účelem detekce arteriální stěny a měření vrstev intima-media

    OpenAIRE

    Beneš, Radek

    2013-01-01

    Tato práce je zaměřena na problematiku měření šířky vrstev intima a media (intima media thickness), která se z medicínského pohledu ukazuje jako vhodná pro ohodnocení rizik plynoucích z různých onemocnění kardiovaskulárního systému. Šířka intima media je měřena v ultrazvukovém obraze, který zobrazuje arterii carotis communis v jejím podélném řezu, ve kterém jsou patrné měřené vrstvy intima a media. Práce zahrnuje teoretickou analýzu problematiky z technického i medicínského pohledu a shrnuje ...

  6. Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population.

    LENUS (Irish Health Repository)

    2010-06-01

    This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) and with the 3-year IMT progression in different carotid segments.

  7. Border Detection of Common Carotid Artery Using Hough Transform

    Science.gov (United States)

    Koya, Yoshiharu; Nagahara, Yoshihiro

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility and high accuracy. The conventional methods to detect the border curve depend on differential value of brightness on the common carotid artery. Therefore, we can't extract a good candidate point by influence of a noise. In this paper, we propose the high-accuracy detection method by Hough Transform. About high-accuracy, it realized by attaching importance to high reliable candidate point of border.

  8. Hyperuricemia and carotid artery dilatation among young adults without metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Eswar Krishnan

    2012-10-01

    Full Text Available It is not known if hyperuricemia is associated with early vascular changes signifying arteriosclerosis. We performed a cross sectional study of 163 young adults without metabolic syndrome in Allegheny County, PA, USA. Doppler ultrasound was used to measure two metrics of early arteriosclerosis: carotid artery dimensions and aortic pulse wave velocity. Individuals in the highest quartiles of serum uric acid (>6.2 mg/dL for men and >4.6 for women were more likely to be of younger age, and to possess greater measures of adiposity and an adverse cardiovascular risk profile. Higher serum uric acid concentration was associated with larger luminal and adventitial diameters as well as changes in diameters between the phases of the cardiac cycle (P<0.001 but not with carotid intima media thickness, pulse wave velocity, or pressure strain modulus. In multivariable linear regression models where the effects of age, ethnicity, serum creatinine, systolic blood pressure, current alcohol use, body mass index and smoking status were accounted for, the highest quartile of serum uric acid was associated with greater luminal and adventitial diameters and change in luminal diameter between the phases of cardiac cycle (P<0.05, but not with pulse wave velocity, pressure strain modulus or carotid intima media thickness. We can conclude that hyperuricemia is associated with larger carotid artery diameters signifying an early adaptive response to vascular stress. This has implications on the observed link between hyperuricemia and hypertension.

  9. Ultrasound settings significantly alter arterial lumen and wall thickness measurements

    OpenAIRE

    Green Daniel J; Reed Christopher J; Potter Kathleen; Hankey Graeme J; Arnolda Leonard F

    2008-01-01

    Abstract Background Flow-mediated dilation (FMD) and carotid intima-medial thickness (CIMT), measured by ultrasound, are widely used to test the efficacy of cardioprotective interventions. Although assessment methods vary, automated edge-detecting image analysis software is routinely used to measure changes in FMD and CIMT. We aimed to quantify the effect that commonly adjusted ultrasound settings have on arterial lumen and wall thickness measurements made with CIMT measurement software. Meth...

  10. Border detection on Common Carotid Artery using Gauss-Markov Estimation

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility, high accuracy and high-speed. In this paper, we propose the high-accuracy and high-speed detection method by Gauss-Markov estimation. About high-accuracy, it realized by attaching importance to high reliable candidate point of border. And, about high-speed, it realized by calculating matrix only one time.

  11. Study on Relationship Between Intima Medial Thickness and the Plaque in Stroke Patients on Carotid Artery Sonography

    International Nuclear Information System (INIS)

    The carotid intima-media thickness (IMT) is an early structural marker of the atherosclerotic process and is the only non-invasive test that is currently recommended by the American Heart Association for evaluation of the risk. However, use of this parameter has a limitation because it assumes uniform thickness throughout the blood vessel, whereas atherosclerosis is a focal phenomenon that is confined to intima. In fact, plaque can be found along the atherosclerotic blood vessels even though its value is unknown. The aim of this study is to analyze the carotid plaque and IMT in the stroke patients. We investigated the patients with ischemic stroke, who were admitted to the department of neurology at the Stroke Special Hospital from January to March 2008. After the carotid IMT and plaque were assessed by B-mode ultrasonography, IMT and carotid plaque to risk variables (age, sex) were analyzed. The distribution of CCA IMT was significantly different in terms of age (p = 0.004). Likewise, the distribution of carotid plaque was also significantly different in terms of age (p = 0.006). Carotid plaque was 69 and 92% in normal and abnormal CCA IMTs respectively. The results showed that the CCA IMT was closely associated with carotid plaque.

  12. Ultrasound settings significantly alter arterial lumen and wall thickness measurements

    Directory of Open Access Journals (Sweden)

    Green Daniel J

    2008-01-01

    Full Text Available Abstract Background Flow-mediated dilation (FMD and carotid intima-medial thickness (CIMT, measured by ultrasound, are widely used to test the efficacy of cardioprotective interventions. Although assessment methods vary, automated edge-detecting image analysis software is routinely used to measure changes in FMD and CIMT. We aimed to quantify the effect that commonly adjusted ultrasound settings have on arterial lumen and wall thickness measurements made with CIMT measurement software. Methods We constructed phantom arteries from a tissue-mimicking agar compound and scanned them in a water bath with a 10 MHz multi-frequency linear-array probe attached to a high-resolution ultrasound machine. B-mode images of the phantoms were recorded with dynamic range (DR and gain set at five decibel (dB increments from 40 dB to 60 dB and -10 dB to +10 dB respectively. Lumen diameter and wall-thickness were measured off-line using CIMT measurement software. Results Lumen measurements: there was a strong linear relationship between DR and gain and measured lumen diameter. For a given gain level, a 5 dB increase in DR reduced the measured lumen diameter by 0.02 ± 0.004 mm (p CIMT measurements: For a fixed gain level, a 5 dB increase in DR increased measured wall thickness by 0.003 ± 0.002 mm (p Conclusion DR, gain and probe distance significantly alter lumen diameter and CIMT measurements made using image analysis software. When CIMT and FMD are used to test the efficacy of cardioprotective interventions, the DR, gain and probe position used to record baseline scans should be documented and replicated in post-treatment scans in individual trial subjects. If more than one sonographer or imaging centre is used to collect data, the study protocol should document specific DR and gain settings to be used in all subjects.

  13. Correlation Between Serum Leptin Level and Intima-Media Thickness of Carotid Artery in Chronic Kidney Disease Patients%慢性肾脏病患者血清瘦素水平与颈动脉内膜-中层厚度的关系

    Institute of Scientific and Technical Information of China (English)

    李绍梅; 祝俊琪; 张丽萍; 傅淑霞; 杨林; 谭会斌

    2010-01-01

    目的 探讨慢性肾脏病患者血清瘦素水平与颈动脉内膜-中层厚度的关系.方法 选择79例慢性肾脏病非透析患者和15例健康对照者,采用放射免疫法测定血清瘦素水平,用高分辨二维颈动脉超声技术测定颈动脉内膜一中层厚度及粥样硬化斑块.结果 慢性肾脏病患者血清瘦素水平、平均颈动脉内膜-中层厚度和动脉粥样斑块检出率明显高于健康对照组(P<0.01).慢性肾脏病伴颈动硬化组(颈动脉内膜-中层厚度≥1.0mm,和/或颈动脉斑块)较无颈动脉硬化组血清瘦素(17.06±1.061ng/L比14.27±0.70ng/L)和C.反应蛋白(3.32±0.19mg/L比2.55±0.17mg/L)水平明显升高(P<0.01);慢性肾脏病患者血清瘦素与尿素氮、肌酐、C-反应蛋白、体质指数呈显著正相关(r=0.293,P<0.01;r=0.324,P<0.01;r=0.539,P<0.01;r=0.312,P<0.05);与肾小球滤过率、血红蛋白、白蛋白呈显著负相关(r=-0.389,P<0.01;r=-0.454,P<0.01;r=-0.246,P<0.05).瘦素(β=1.527,P<0.05)是慢性肾脏病患者并发动脉粥样硬化的独立危险因素.结论 慢性肾脏病患者存在高瘦素血症,高瘦素血症与颈动脉内膜-中层厚度的关系,其可能参与了慢性肾脏病患者动脉粥样硬化的发生和发展.

  14. 代谢综合征患者静息心率与颈动脉内膜中层厚度的关系%Relationship between resting heart rate and carotid arterial intima-media thickness in patients with metabolic syndrome

    Institute of Scientific and Technical Information of China (English)

    高华; 郝俊芳; 杨锐英

    2008-01-01

    目的 探讨代谢综合征(MS)患者静息心率(RHR)与颈动脉内膜-中层厚度(IMT)的关系.方法 对96例MS患者进行调查,每位患者均测RHR、血压、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆同醇(LDL-C),颈动脉超声检测IMT,按RHR频率分RHRl组:RHR<70次/min,RHR2组:70~80次/min,RHR3组:RHR<80次/min.结果 代谢综合征患者RHR与IMT呈显著正相关(r=0.432 P<0.01);且RHR与FIG、TG呈正相关(FPG r=0.24,TG r=0.24,P<0.05.结论 MS患者RHR与IMT有明显相关性.

  15. The effect of metabolic syndrome on glomerular filtration rate and carotid artery intima-media thickness old hypertensive pa-tients%代谢综合征对老年高血压患者肾小球滤过率及颈动脉内膜中层厚度的影响

    Institute of Scientific and Technical Information of China (English)

    张铁强; 刘渝; 宋金辉; 侯建军

    2008-01-01

    目的 探讨代谢综合征对老年高血压患者肾小球滤过率(GFR)及颈动脉内膜中层厚度(INT)的影响.方法 60例未经治疗的老年高血压患者均进行血压、腰围测量及血糖、血脂、肾功能检查,其中30例符合代谢综合征诊断标准(ATP Ⅲ标准)作为研究组,其余30例仅有高血压无代谢综合征者作为对照组.2组均进行颈动脉超声检查测定颈动脉IMT,根据简化的MDRD方程计算GFR,CFR<60 ml·min-1·1.73 m-2诊断为慢性肾病.结果 研究组与对照组GFR分别为(98.4±0.5)ml·min-1·1.73 m-2和(119.1±11.9)ml·min-1·1.73 m2(P<0.01).2组中GFR<60 ml·min-1·1.73 m-2的患者分别为26.7%与10.0%(P<0.05),IMT分别为(0.62±0.18)mm和(0.58±0.22)mm(P<0.05).结论 代谢综合征组GFR明显低,慢性肾病增加,IMT明显增加.

  16. 短暂性脑缺血发作患者颈总动脉内中膜厚度与颅外血管事件及脑卒中复发相关性研究%Correlation Study Between Carotid Artery Intima-media Thickness and Extracranial Vascular Event or Stroke Recurrent

    Institute of Scientific and Technical Information of China (English)

    王晓蓉; 李先浪; 郑志军; 杜纯忠; 叶淮松; 俞怡; 邵宝尔

    2015-01-01

    目的 探讨TIA患者颈总动脉内中膜厚度(CCA-IMT)与颅外血管事件和脑卒中复发的相关性.方法 研究共纳入212名TIA患者,采集患者一般情况资料、临床特征和疾病情况,进行头部CT检查和颈动脉超声检测,分析CCA-IMT与TIA风险因素的相关性;对患者进行为期1年的随访观察,分析CCA-IMT与颅外血管事件以及脑卒中复发的预测效应.结果 共发生24例颅外血管事件(18例冠心病和6例外周血管病)和16例脑卒中复发.CCA-IMT与TIA多种风险因素相关,男性年龄> 60岁以及具有高血压、冠心病患病史的患者中CCA-IMT显著增加.生存分析结果CCA-IMT对颅外血管事件具有良好的预测效应,CCA-IMT值>0.939mm患者颅外血管事件风险显著增加(P =0.000).结论 CCA-IMT较高TIA患者颅外血管事件风险增加,CCA-IMT对TIA患者颅外血管事件具有良好的预测作用,可作为临床上常用的预测手段.

  17. Early Evaluation of Common Carotid Arterial lntima-media Thickness and Elasticity in Hypertriglyceridemia Patients using Ultrasound Radio Frequency Data Technology%射频数据处理技术早期评价高甘油三脂血症患者颈总动脉内-中膜厚度和血管弹性

    Institute of Scientific and Technical Information of China (English)

    丹海俊; 王燕; 沙海静; 温树彬; 贾丽梅; 卢宝金

    2011-01-01

    Objective To quantify the intima-media thickness(IMT) and arterial elasticity of the common carotid artery (CCA) in clinically asymptomatic subjects of hypertriglyceridemia( HTG) using ultrasound radio frequency data technology .the correlatios were also evaluated. Methods 30 HTG patients and 30 normal subjects were enrolled in the study. The common carotid arterial systolic diameter (Ds) ..diastolic diameter(Dd) ,intima-media thickness(IMT), carotid distensibility(CD), local pulse wave velocity(PWV|3) and stiffness ((3) were compared between the two groups. The correlations between these data and hypertriglyceridemia were analyzed. Results (1)CCA-IMT,PWV(3 and |3 were increased while CD was decreased more significantly in HTG patients than those in normal subjects. Common carotid arterial Ds,Dd were not statistically significant in the two groups. (2)The level of hypertriglyceridemia had significant positive correlations with CCA-IMT while no significant correlations with CD,PWV)3 and (3. Conclusions Ultrasound radio frequency data technology could quantitativly and accurativly evaluate the early change of common carotid arterial structure and function in HTG patients comparing with normal subjects.%目的 探讨高频超声射频数据处理技术(RF-data)早期评价高甘油三脂血症(HTG)患者颈总动脉内-中膜厚度和血管弹性改变及相关分析.方法 比较30例HTG患者与30例正常人颈总动脉收缩期内径(Ds)、舒张期内径(Dd)、内-中膜厚度(IMT)、颈总动脉扩张性(CD)、单点脉搏波传播速度(PWVβ)、僵硬度(β)的改变,并分析甘油三脂与颈总动脉IMT、CD、PWVβ、β之间的相关性.结果 (1) HTG组左、右侧颈总动脉IMT、PWVβ、β均显著高于正常对照组;CD显著低于对照组(P<0.05).HTG组双侧颈总动脉Ds、Dd与对照组差异无显著性意义.(2) HTG组甘油三脂升高的水平与颈总动脉IMT呈显著正相关(r=0.237,P<0.05);而与CD、PWVβ、

  18. The Use of Carotid Artery Ultrasonography in Different Clinical Conditions

    OpenAIRE

    Gasparyan, Armen Yuri

    2009-01-01

    B-mode ultrasonography of the carotid artery is a non-invasive, informative and reproducible technique used for the assessment of prevalence and course of atherosclerosis in a variety of clinical conditions. Visualization of intima-media complex, atherosclerotic plaques, rough arterial wall and calcifications of the carotid artery may be useful for the assessment of atherosclerotic burden. The latter was confirmed in a recent consensus statement of the American Society of Echocardiography. De...

  19. Low prevalence of peripheral arterial disease in a cross-sectional study of Danish HIV-infected patients

    DEFF Research Database (Denmark)

    Knudsen, Andreas; Malmberg, Catarina Anna Evelina; Kjær, Andreas;

    2015-01-01

    BACKGROUND: Patients infected with human immunodeficiency virus (HIV) appear to be at increased risk of cardiovascular disease (CVD). The ankle-brachial index (ABI) is a well-established screening tool for peripheral arterial disease (PAD) and future cardiovascular events in the general population...... or cIMT. Based on these results ABI does not seem valuable as a screening tool for CVD among HIV-infected patients........ However, controversies exist on the prevalence of PAD among HIV-infected patients. In this study we aimed to measure the prevalence of PAD among HIV-infected patients and compare the ABI with carotid intima-media thickness (cIMT) and other known CVD risk predictors. METHODS: We prospectively included HIV...

  20. Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects

    Directory of Open Access Journals (Sweden)

    Christian F. Rueda-Clausen

    2009-01-01

    Full Text Available Introduction. Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT in dyslipidemic patients with or without coronary artery disease (CAD. Methods. Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n=33 and without (−CAD, n=69 symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound. Results. No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however no significant differences in FMD or plasma levels of nitrites were observed. Conclusions. In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.

  1. Endothelial dysfunction, carotid artery plaque burden, and conventional exercise-induced myocardial ischemia as predictors of coronary artery disease prognosis

    Directory of Open Access Journals (Sweden)

    Ishihara Masayuki

    2008-12-01

    Full Text Available Abstract Background While both flow-mediated vasodilation (FMD in the brachial artery (BA, which measures endothelium-dependent vasodilatation, and intima-media thickness (IMT in the carotid artery are correlated with the prognosis of coronary artery disease (CAD, it is not clear which modality is a better predictor of CAD. Furthermore, it has not been fully determined whether either of these modalities is superior to conventional ST-segment depression on exercise stress electrocardiogram (ECG as a predictor. Thus, the goal of the present study was to compare the predictive value of FMD, IMT, and stress ECG for CAD prognosis. Methods and Results A total of 103 consecutive patients (62 ± 9 years old, 79 men with clinically suspected CAD had FMD and nitroglycerin-induced dilation (NTG-D in the BA, carotid artery IMT measurement using high-resolution ultrasound, and exercise treadmill testing. The 73 CAD patients and 30 normal coronary patients were followed for 50 ± 15 months. Fifteen patients had coronary events during this period (1 cardiac death, 2 non-fatal myocardial infarctions, 3 acute heart failures, and 9 unstable anginas. On Kaplan-Meier analysis, only FMD and stress ECG were significant predictors for cardiac events. Conclusion Brachial endothelial function as reflected by FMD and conventional exercise stress testing has comparable prognostic value, whereas carotid artery plaque burden appears to be less powerful for predicting future cardiac events.

  2. Analysis of the population at high risk of stroke detected with carotid artery ultrasonography in Tianjin urban communities

    Directory of Open Access Journals (Sweden)

    Wei YUE

    2015-04-01

    Full Text Available Objective To investigate the features of carotid atherosclerosis in a population at high risk of stroke in urban communities of Tianjin, so as to provide inspiration for carotid ultrasonography to play a greater role in the prevention and control of stroke.  Methods A total of 956 residents at high risk of stroke were selected from 4 urban communities in Tianjin using cluster random sampling method. Doppler ultrasound screening was performed in bilateral common carotid artery (CCA, internal carotid artery (ICA, external carotid artery (ECA, vertebral artery (VA, subclavian artery (SCA and innominate artery of the population. The intima-media thickness (IMT, atherosclerotic plaque formation and its location and size, vascular stenosis or occlusion, and flow spectrum were detected. The results and features of carotid ultrasound screening were analyzed and compared among different gender and age groups.  Results 1 The detection rate of carotid atherosclerosis was 71.55% (684/956, and the detection rate in males was significantly higher than that in females (79.08% vs 65.87%; χ2 = 20.067, P = 0.000. 2 Among the population with carotid atherosclerosis, the most common manifestation was the formation of atherosclerotic plaques (81.58%, 558/684, secondly intima-media thickening (13.01%, 89/684, followed by moderate to severe stenosis or occlusion (5.41%, 37/684. The proportion of intima-media thickening in males was lower than that in females (7.08% vs 18.38%; χ2 = 19.269, P = 0.000. The proportion of carotid atherosclerotic plaque formation in males was higher than that in females (86.46% vs 77.16%; χ2 = 9.824, P = 0.002. The median rating of carotid atherosclerosis was 1.79, with males higher than females [1.98 (0.70, 3.26 vs 1.52 (0.20, 2.84; Z = 2.304, P = 0.042]. The site of plaque formation was most commonly located in carotid bulb (36.61%, secondly SCA (22.18%. Of the type of carotid stenosis, ICA stenosis was detected in 30 cases, VA

  3. Optimization of Condition of Ultrasonic Beam for Measurement of Small Change in Thickness of Arterial Wall

    Science.gov (United States)

    Watanabe, Masaru; Hasegawa, Hideyuki; Kanai, Hiroshi

    2002-05-01

    We previously developed a method for measuring small changes in thickness of the arterial wall during one cardiac cycle. Knowledge of this change in thickness is useful for in vivo assessment of the regional elasticity of the arterial wall. In this study, from computer simulations, it is found that measurement error depends on the distance of the ultrasonic beam from the center of the artery and it can be reduced by optimally setting the focal position. In basic experiments using a silicone rubber tube and in in vivo experiments with a human carotid artery, it is found that by optimizing the focal position, measurement of the change in thickness becomes more robust against mispositioning of the ultrasonic beam. From these results, it is demonstrated that optimum focal positioning provides more robustness in measurement, even if there is arterial wall motion causing the position of the ultrasonic beam to deviate from the center of the artery.

  4. A study on the carotid artery ultrasonography for the metabolic syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Hye Jung; Cho, Pyong Kon [Dept. of Radiological Science, Catholic University of Daegu, Daegu (Korea, Republic of); Kang, Young Han [Dept. of Radiology, Catholic University Hospital of Daegu, Daegu (Korea, Republic of)

    2013-09-15

    The primary goal of this study was to ascertain the primary factors to the affect for the carotid artery intima-media thickness (IMT), the prevalence of metabolic syndrome and other risks can possibly influence the carotid artery IMT. All patients data (total specimens: 289, male: 197, female: 92) including the carotid artery ultrasonography examination. The all data were analyzed by the use of SPSS software, version 21.0 (SPSS, Chicago, IL USA), with the descriptive statistics method. The Results of this study was found to be highly increased in the males than the females. The prevalence of metabolic syndrome in all of the participants was 30.5 percentages. The carotid artery IMT in the subjects with metabolic syndrome was significantly high in both genders, compared to the rest, who were without metabolic syndrome. The Pearsons correlation coefficient of metabolic syndrome and CIMT was 0.378(p<0.01). In conclusions, the present study also supports the association between the carotid artery IMT and the metabolic syndromes with cardiovascular risk factors. Usage of B-mode ultrasonography to measure the carotid artery IMT was found to be highly effective in the current analysis.

  5. Blood serum atherogenicity and coronary artery calcification.

    Science.gov (United States)

    Sobenin, Igor A; Myasoedova, Veronica A; Anisimova, Elena V; Pavlova, Xenia N; Möhlenkamp, Stefan; Schmermund, Axel; Seibel, Rainer; Berenbein, Sina; Lehmann, Nils; Moebus, Susanne; Jöckel, KarlHeinz; Orekhov, Alexander N; Erbel, Raimund

    2014-01-01

    The phenomenon of blood serum atherogenicity was described as the ability of human serum to induce lipid accumulation in cultured cells. The results of recent two-year prospective study in asymptomatic men provided the evidence for association between the changes in serum atherogenicity and dynamics of carotid intima-media thickness progression. The present study was undertaken to test the hypothesis that blood serum atherogenicity and its changes in dynamics may be associated with accumulation of coronary calcium in subclinical atherosclerosis. It was performed in 782 CHD-free participants of The Heinz Nixdorf RECALL (Risk Factors, Evaluation of Coronary Calcium and Lifestyle) Study, in whom blood samples have been taken at the baseline and at the end of 5-year follow-up. Opposite to the previous findings, the changes in serum atherogenicity did not correlate neither with the extent of coronary artery calcification, nor with the changes in Agatston CAC score. There was a moderate but significant rise in serum atherogenicity after 5-year followup period, and the same dynamics was observed for Agatston CAC score, but not for convenient lipid-related risk factors. The absence of association of the changes in serum atherogenicity with the changes in Agatston CAC score, along with previous findings, provides a point of view that serum-induced intracellular cholesterol accumulation is not related to the processes of calcium deposition in arterial wall, since the last one reflects the progression of already existing subclinical atherosclerotic lesions. PMID:24533940

  6. Cortisol in urine and saliva

    DEFF Research Database (Denmark)

    Hurwitz Eller, N; Netterstrøm, B; Hansen, Åse Marie

    2001-01-01

    The objective of the study was to analyse the relations between excretion of cortisol in urine and saliva and the intima media thickness (IMT) of the artery carotis communis.......The objective of the study was to analyse the relations between excretion of cortisol in urine and saliva and the intima media thickness (IMT) of the artery carotis communis....

  7. Development of 3D ultrasound techniques for carotid artery disease assessment and monitoring

    International Nuclear Information System (INIS)

    Quantitative measurements of carotid plaque burden are used to monitor patients and evaluate established interventions as well as new treatment options. Three-dimensional ultrasound (3D US) techniques were developed to noninvasively monitor the progression of carotid artery disease in both symptomatic and asymptomatic patients. Three-dimensional carotid US images were acquired and reconstructed, and methods for quantitative assessment were developed. The measurement of intima-media thickness (IMT) based on two-dimensional ultrasound (2D US) images was extended to a 3D vessel-wall-plus- plaque thickness (VWT), obtained by computing the distance between the carotid wall and lumen surfaces on a point-by-point basis. VWT measurements were superimposed on the arterial wall to produce 3D VWT maps. VWT changes were determined by comparing the 3D VWT maps obtained at two different time points. To facilitate the visualization and interpretation of the VWT and VWT-Change maps, a technique to flatten these maps was developed. Carotid remodeling involving changes in both arterial wall and plaque thickness was assessed with VWT maps obtained from in vivo 3D ultrasound images. 3D carotid ultrasound image evaluation with VWT mapping provides a feasible means for the analysis of plaque burden volumes and changes. (orig.)

  8. Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study

    Directory of Open Access Journals (Sweden)

    Patino-Alonso Maria C

    2011-04-01

    Full Text Available Abstract Background Ambulatory blood pressure monitoring (ABPM shows a better correlation to target organ damage and cardiovascular morbidity-mortality than office blood pressure. A loss of arterial elasticity and an increase in carotid artery intima-media thickness (IMT has been associated with increased cardiovascular morbidity-mortality. Tools have been developed that allow estimation of the retinal arteriovenous index but not all studies coincide and there are contradictory results in relation to the evolution of the arteriosclerotic lesions and the caliber of the retinal vessels. The purpose of this study is to analyze the relationship between peripheral and central arterial pressure (clinic and ambulatory and vascular structure and function as evaluated by the carotid artery intima-media thickness, retina arteriovenous index, pulse wave velocity (PWV and ankle-brachial index in patients with and without type 2 diabetes. In turn, software is developed and validated for measuring retinal vessel thickness and automatically estimating the arteriovenous index. Methods/Design A cross-sectional study involving a control group will be made, with a posterior 4-year follow-up period in primary care. The study patients will be type 2 diabetics, with a control group of non-diabetic individuals. Consecutive sampling will be used to include 300 patients between 34-75 years of age and no previous cardiovascular disease, one-half being assigned to each group. Main measurements: age, gender, height, weight and abdominal circumference. Lipids, creatinine, microalbuminuria, blood glucose, HbA1c, blood insulin, high sensitivity C-reactive protein and endothelial dysfunction markers. Clinic and ambulatory blood pressure monitoring. Carotid ultrasound to evaluate IMT, and retinography to evaluate the arteriovenous index. ECG to assess left ventricle hypertrophy, ankle-brachial index, and pulse wave analysis (PWA and pulse wave velocity (PWV with the Sphigmocor

  9. Impact of exercise training on arterial wall thickness in humans.

    NARCIS (Netherlands)

    Thijssen, D.H.J.; Cable, N.T.; Green, D.J.

    2012-01-01

    Thickening of the carotid artery wall has been adopted as a surrogate marker of pre-clinical atherosclerosis, which is strongly related to increased cardiovascular risk. The cardioprotective effects of exercise training, including direct effects on vascular function and lumen dimension, have been co

  10. Age related changes in histomorphology of medium sized muscular artery

    International Nuclear Information System (INIS)

    The aim of this study was to contribute to the knowledge of histomorphometric changes which are associated with increasing age in local population, with the experience obtained in the dissection on cadavers. Study Design: Cross-sectional comparative study Place and Duration of Study: The study was carried out at the department of Anatomy, Army Medical College Rawalpindi in collaboration with Forensic departments of various medical institutes where cadavers were brought for autopsy, spanning from 15 Feb 2010 to 15 Aug 2010. Material and Methods: A total of forty cadavers from local population (Punjab and Khyber Pakhtunkhwa) were dissected and specimen (Common hepatic artery) (CHA) were obtained. Two age groups, one below the age of forty years (1 to 39 years) and the other above the age of forty years (40 to 70 years) were made. The specimen were processed and stained with Hematoxylin and Eosin. Using a microscope with 10 X objective, micrometry was done and data of intima thickness (IT), media thickness (MT) and intima media thickness (IMT) was noted. Results: After comparing the two age groups, statistically significant difference was found between the IT (p value <0.01). The mean values of media failed to attain any statistical difference. No statistically significant difference was found in the IMT of the two age groups. Conclusion: Increase in intima thickness was found while MT and IMT did not show any statistical difference. (author)

  11. Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force.

    Science.gov (United States)

    Dutta, Parikshit; Urban, Matthew W; Le Maître, Olivier P; Greenleaf, James F; Aquino, Wilkins

    2015-07-01

    The elastic and geometric properties of arteries have been long recognized as important predictors of cardiovascular disease. This work presents a robust technique for the noninvasive characterization of anisotropic elastic properties as well as thickness and diameter in arterial vessels. In our approach, guided waves are excited along arteries using the radiation force of ultrasound. Group velocity is used as the quantity of interest to reconstruct elastic and geometric features of the vessels. One of the main contributions of this work is a systematic approach based on sparse-grid collocation interpolation to construct surrogate models of arteries. These surrogate models are in turn used with direct-search optimization techniques to produce fast and accurate estimates of elastic properties, diameter, and thickness. One of the attractive features of the proposed approach is that once a surrogate model is built, it can be used for near real-time identification across many different types of arteries. We demonstrate the feasibility of the method using simulated and in vitro laboratory experiments on a silicon rubber tube and a porcine carotid artery. Our results show that using our proposed method, we can reliably identify the longitudinal modulus, thickness, and diameter of arteries. The circumferential modulus was found to have little influence in the group velocity, which renders the former quantity unidentifiable using the current experimental setting. Future work will consider the measurement of circumferential waves with the objective of improving the identifiability of the circumferential modulus. PMID:26109582

  12. Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force

    International Nuclear Information System (INIS)

    The elastic and geometric properties of arteries have been long recognized as important predictors of cardiovascular disease. This work presents a robust technique for the noninvasive characterization of anisotropic elastic properties as well as thickness and diameter in arterial vessels. In our approach, guided waves are excited along arteries using the radiation force of ultrasound. Group velocity is used as the quantity of interest to reconstruct elastic and geometric features of the vessels. One of the main contributions of this work is a systematic approach based on sparse-grid collocation interpolation to construct surrogate models of arteries. These surrogate models are in turn used with direct-search optimization techniques to produce fast and accurate estimates of elastic properties, diameter, and thickness. One of the attractive features of the proposed approach is that once a surrogate model is built, it can be used for near real-time identification across many different types of arteries. We demonstrate the feasibility of the method using simulated and in vitro laboratory experiments on a silicon rubber tube and a porcine carotid artery. Our results show that using our proposed method, we can reliably identify the longitudinal modulus, thickness, and diameter of arteries. The circumferential modulus was found to have little influence in the group velocity, which renders the former quantity unidentifiable using the current experimental setting. Future work will consider the measurement of circumferential waves with the objective of improving the identifiability of the circumferential modulus. (paper)

  13. Ultrasonic Measurement of Change in Elasticity due to Endothelium Dependent Relaxation Response by Accurate Detection of Artery-Wall Boundary

    Science.gov (United States)

    Kaneko, Takuya; Hasegawa, Hideyuki; Kanai, Hiroshi

    2007-07-01

    Ross hypothesized that an endothelial dysfunction is considered to be an initial step in atherosclerosis. Endothelial cells, which release nitric oxide (NO) in response to shear stress from blood flow, have a function of relaxing smooth muscle in the media of the arterial wall. For the assessment of the endothelial function, there is a conventional method in which the change in the diameter of the brachial artery caused by flow-mediated dilation (FMD) is measured with ultrasound. However, despite the fact that the collagen-rich hard adventitia does not respond to NO, the conventional method measures the change in diameter depending on the mechanical property of the entire wall including the adventitia. Therefore, we developed a method of measuring the change in the thickness and the elasticity of the brachial artery during a cardiac cycle using the phased tracking method for the evaluation of the mechanical property of only the intima-media region. In this study, the initial positions of echoes from the lumen-intima and media-adventitia boundaries are determined using complex template matching to accurately estimate the minute change in the thickness and the elasticity of the brachial and radial arteries. The ambiguity in the determination of such boundaries was eliminated using complex template matching, and the change in elasticity measured by the proposed method was larger than the change in inner diameter obtained by the conventional method.

  14. Optimization of Focal Position of Ultrasonic Beam in Measurement of Small Change in Arterial Wall Thickness

    Science.gov (United States)

    Watanabe, Masaru; Kanai, Hiroshi

    2001-05-01

    We have previously developed a method for measurement of a small change in thickness of the arterial wall during a single cardiac cycle [H. Kanai, M. Sato, Y. Koiwa and N. Chubachi: IEEE Trans. UFFC 43 (1996) 791]. The resultant change in thickness is shown to be useful for the in vivo assessment of the regional elasticity of the arterial wall. Although the accuracy of the measurement of the change in thickness is found to be within 1 μm, it is affected by the interference of ultrasonic pulses. In this study, we simulate the propagation of ultrasonic pulses transmitted and received by a linear probe. In the simulation experiments, the ultrasonic pulses generated by a computer are reflected by a tube, which has a small change in wall thickness of 10 μm. The optimum focal position of the ultrasonic beam is determined by evaluating the root-mean-square (rms) error in the measured change in thickness.

  15. Arterial Thickness and Immunometabolism: The Mediating role of Chronic Exercise.

    Science.gov (United States)

    Antunes, B M M; Cayres, S U; Lira, F S; Fernandes, R A

    2016-01-01

    Metabolic alterations and cardiovascular diseases, such as atherosclerosis, are associated with lifestyle modifications, particularly the increase of physical inactivity and poor eating habits, which contribute to one of the main causes of death in modern times. Cardiovascular diseases are positively correlated with several illnesses, such as obesity, hypertension and dyslipidemia, and these disorders are known to contribute to changes in immune cells, cytokines and metabolism. Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid plaques and fibrous tissue (atheroma) in the artery walls and this process is related to the oxidation of LDL-c (low density lipoprotein) and the formation of a particle, termed LDLox, which can generate toxic injury to the vessel wall. In this atherogenic process there is an inflammatory response generated by the injury in the vascular endothelium, which in itself is able to express and secrete a variety of molecules, such as myeloid colony-stimulating factors (M-CSF), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-α), that act as activators of the immune system. Therefore, the main purpose of this review is to highlight the immuno-metabolic alterations involving the thickening and stiffness of arteries observed in atherosclerosis, and how chronic exercise can act as an anti-inflammatory and anti-atherogenic approach. PMID:26818486

  16. Sonographic assessment of carotid artery in postmenopausal women receiving long-term low-dose hormone replacement therapy

    Institute of Scientific and Technical Information of China (English)

    Wang Hong-yan; Jiang Yu-xin; Meng Hua; Ge Qin-sheng

    2004-01-01

    Objective: The aim of this study was to determine the influence of long-term low-dose hor mone replacement therapy (HRT) on the intima-media wall of the carotid artery in postmenopa usal women by ultrasound.Methods: 146 postmenopausal women were divided into the HRT group(n= 68, HRT over 5years after menopause) and the control group(n= 78, no HRT). The intima-media thickness (IMT) of the carotid arteries was measured bilaterally, the characteristics of the atherosclerotic plaques were described, the peak systolic velocity (PSV) and resistance index (RI) were measured by ultrasound examination.Results: The IMT of HRT group was significantly smaller than that of the control group,(0. 089±0. 22) cm vs (0. 093±0.29) cm, (P<0. 01). The occurrence of plaques was reduced in HRT group than the control group (7.7% vs 12.7%, P<0. 05). The plaques were most frequently found at the bifurcation of the arteries. The soft and mixed plaques in HRT group were found significantly less than that of the control group (soft 1.7% vs 4. 5%, mixed 3.1% vs 6. 7%, both P<0.05), while the hard plaques in HRT group were more than those of the control group(2.6% vs 1.3%, P<0. 05). The maximum plaque thickness of HRT group was less than that of control group (0. 191±0. 057) cm vs (0. 226±0. 073) cm, (P<0.05). The internal carotid artery PSV and RI in the two groups were similar [PSV (65.61±26.55) cm/s vs (64.82±27. 22) cm/s, RI (0.67±0. 082) vs (0. 68±0. 075), both P>0.05].Conclusion: Our study indicated that HRT may has an effect to reduce the carotid IMT thickness, inhibit the plaque formation, and make the plaques harder and more stable. The long-term low-dose HRT may protect the postmenopausal women against the artherosclerosis of the carotid artery.

  17. Evaluating arterial stiffness in type 2 diabetes patients using ultrasonic radiofrequency.

    Science.gov (United States)

    Li, Zhao-Jun; Liu, Yang; Du, Lian-Fang; Luo, Xiang-Hong

    2016-06-01

    Differences in arterial stiffness between the two sides of the carotid arteries were investigated using ultrasonic radiofrequency in 88 patients with type 2 diabetes and 70 controls. The compliance coefficient (CC), pulse wave velocity (PWV), intima-media thickness (CIMT) and diameter (CCAD) of the common carotid arteries (CCAs) were measured. The ratio of the left to right CCAs was calculated to provide four indexes: CC ratio, PWV ratio, CIMT ratio and CCAD ratio. In the diabetes group, the PWV on the left side was significantly higher than that on the right side, while the CC on the left side was significantly lower than that on the right side. The bilateral CIMT was thicker and CCAD was wider, the left PWV traveled faster, and the right CC was higher in the diabetes group than in the control group. The PWV ratio between the two groups was significantly different and correlated positively with duration of diabetes and systolic blood pressure (SBP). The differences between the two sides of CCAs in patients with diabetes suggested that disease duration and SBP were important risk factors for arterial stiffness. Identifying the difference could potentially lead to the much earlier diagnosis of arteriosclerosis. PMID:27376818

  18. The dynamic of aterosclerosis affection on brachio-cefalic arterys of the high risk patients under the hypolipidemic treatment

    Directory of Open Access Journals (Sweden)

    V.V. Simerzin

    2010-06-01

    Full Text Available Purpose. To study the statin influence on lipid exchange and the degree of the brachiocefalic arterys alteration. Methods. The research included 33 high risk patients. The patients inverstigation included lipid spectrum, blood coagulation indexes, by the means of triplex scanning of the brachiochefalic arterys the thickness of the intima - media complex and the expression of stenosis of carotid, vertebral and subclavian arterys were measured. Results. All the patients were divided into the groups according to the total cholesterol and low density lipoprotein cholesterol levels. Patients were divided into subgroups according to the expression of stenosis. The 1 group of patients received rosuvastating 10 mg, the 2 group - atorvastain 20 mg, 3the 3 group - simvastatin 40 mg. This inverstigation shows that the high risk patients with high levels of total cholesterol and low density lipoproteins have the highest expressiveness of brachiocefalic arterys atherosclerosis affection. Conclusion. The assignment of the statins to these patients is accompanied by the lowering of the levels of total cholesterol and low density lipoproteins and the quantity of arteries affected by the atherosclerosis and also by decreasing of the stenosis expression

  19. Growing-Related Changes in Arterial Properties of Healthy Children, Adolescents, and Young Adults Nonexposed to Cardiovascular Risk Factors: Analysis of Gender-Related Differences.

    Science.gov (United States)

    Curcio, S; García-Espinosa, V; Arana, M; Farro, I; Chiesa, P; Giachetto, G; Zócalo, Y; Bia, D

    2016-01-01

    The aims of our work were to determine normal aging rates for structural and functional arterial parameters in healthy children, adolescents, and young adults and to identify gender-related differences in these aging rates. Methods. 161 subjects (mean: 15 years (range: 4-28 years), 69 females) were studied. Subjects included had no congenital or chronic diseases, nor had they been previously exposed to traditional cardiovascular risk factors. Arterial parameters assessed were (1) central blood pressure (BP) and aortic pulse wave analysis, (2) arterial local (pressure-strain elastic modulus) and regional (pulse wave velocity, PWV) stiffness, and (3) arterial diameters and carotid intima-media thickness (CIMT). Simple linear regression models (age as the independent variable) were obtained for all the parameters and the resulting rates of change were compared between genders. Results. No gender-related differences were found in mean values of arterial structural and functional parameters in prepubertal ages (4-8 years), but they started to appear at ~15 years. Boys showed a greater rate of change for central systolic BP, central pulse pressure, CIMT, and carotid-femoral PWV. Conclusion. Gender-related differences in arterial characteristics of adults can be explained on the basis of different growing-related patterns between boys and girls, with no existing differences in prepubertal ages.

  20. CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 1

    Directory of Open Access Journals (Sweden)

    I. D. Strazhesko

    2016-05-01

    Full Text Available Arterial wall status is determined by several characteristics, the main of them are as follows: pulse wave velocity (PWV, carotid arteries intima-media thickness (IMT, the presence of atherosclerotic plaques, endothelium-dependent vasodilation (EDVD. When these parameters change, the risk for cardiovascular disease (CVD grows. The nature of relationship between these indices in people without CVD clinical signs is understudied, especially in those of older age.Aim. To estimate correlations between different parameters of arterial wall in patients of different age without CVD.Material and methods. A total of 303 people aged 25-91 years without any manifestations of CVD or other chronic diseases and without regular medical treatment were examined. PWV estimation, carotid ultrasound with IMT measurement and atherosclerotic plaques amount calculation and EDVD estimation using reactive hyperemia test were performed. Results. Patients without CVD clinical signs rather often reveal arterial wall lesions already in the younger age group (mean age 40.9±8.7: reduced EDVD – in 26% of the cases, the presence of atherosclerotic plaques – in 22%, increased PWV – in 15%, increased IMT – in 8%. The prevalence of arterial wall alterations in the older age group (mean age 61.19±8.5 increase many-fold. All arterial wall parameters correlate with age. The stronger correlation was revealed between IMT and the amount of atherosclerotic plaques: r=0.46 (р<0.001 in the younger group and r=0.47 (р<0.001 in the older one. We didn’t find any relationship between PWV and EDVD in the younger group and between PWV and the amount of atherosclerotic plaques in the older one. Thickened carotid intima-media increases the risk of arterial stiffness by 2.3 times.Conclusion. Estimation of the state of arterial wall in people of young age without CVD allows detecting individuals who require active CVD prevention. Increased stiffness of arterial wall and the development

  1. Ambulatory arterial stiffness indices and target organ damage in hypertension

    Directory of Open Access Journals (Sweden)

    Gómez-Marcos Manuel

    2012-01-01

    Full Text Available Abstract Background The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI - correlates best with vascular, cardiac and renal damage in hypertensive individuals. Methods A cross-sectional study was carried out involving 258 hypertensive patients. AASI and HASI were defined as the 1-regression slope of diastolic over systolic blood pressure readings obtained from 24-hour recordings and home blood pressure over 6 days. Renal damage was evaluated by glomerular filtration rate (GFR and microalbuminuria; vascular damage by carotid intima-media thickness (IMT, pulse wave velocity (PWV and ankle/brachial index (ABI; and left ventricular hypertrophy by the Cornell voltage-duration product (VDP and the Novacode index. Results AASI and HASI were not correlated with microalbuminuria, however AASI and HASI- blood pressure variability ratio (BPVR showed negative correlation with GRF. The Cornell PDV was positively correlated with AASI- BPVR-Sleep (r = 0.15, p Conclusions After adjusting for age, gender and 24-hour heart, the variables that best associated with the variability of IMT, PWV and ABI were AASI and Awake-AASI, and with GFR was HASI-BPVR.

  2. Noninvasive measurements of arterial stiffness: Repeatability and interrelationships with endothelial function and arterial morphology measures

    Directory of Open Access Journals (Sweden)

    Corey J Huck

    2007-07-01

    Full Text Available Corey J Huck1, Ulf G Bronas1, Eric B Williamson1, Christopher C Draheim1, Daniel A Duprez2, Donald R Dengel1,31School of Kinesiology, University of Minnesota, Minneapolis, MN, USA; 2Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN; 3Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USABackground: Many noninvasive arterial assessment techniques have been developed, measuring different parameters of arterial stiffness and endothelial function. However, there is little data available comparing different devices within the same subject. Therefore, the purpose of this study was to examine the repeatability and interrelationships between 3 different techniques to measure arterial stiffness and to compare this with forearm-mediated dilation.Methods: Carotid-radial pulse wave velocity was measured by the Sphygmocor (SPWV and Complior (CPWV devices, cardio-ankle vascular index (CAVI was measured by the VaSera device, vascular structure and function was assessed using ultrasonography and evaluated for reliability and compared in 20 apparently healthy, college-aged men and women.Results: The intraclass correlation coefficient and standard error of the mean for the Sphygmocor (R = 0.56, SEM = 0.69, Complior (R = 0.62, SEM = 0.69, and VaSera (R = 0.60, SEM = 0.56, indicated moderate repeatability. Bland-Altman plots indicated a mean difference of 0.11 ± 0.84 for SPWV, 0.13 ± 1.15 for CPWV, and –0.43 ± 0.90 for CAVI. No significant interrelationships were found among the ultrasound measures and SPWV, CPWV, and CAVI.Conclusions: The three noninvasive modalities to study arterial stiffness reliably measures arterial stiffness however, they do not correlate with ultrasound measures of vascular function and structure in young and apparently healthy subjects.Keywords: Pulse wave velocity, intima-media thickness, flow-mediated dilation

  3. An insight into elasticity analysis of common carotid artery using ultrasonography.

    Science.gov (United States)

    Raj, Jean Rossario; Rahman, Smk; Anand, Sneh

    2016-08-01

    Elastance is a distinguished marker in diagnosing various arterial diseases as studies have reported carotid artery-related diseases linked with stiffness index (β) values greater than 5. This study was to estimate elasticity of common carotid artery by measuring the diameter during systolic and diastolic phases using pixel tracing of successive frames and blood pressure. The B-mode ultrasonography video containing arterial wall motion was captured and fragmented into image frames. Each pixel on the greyscale image was converted into RGB intensity values. The diameter of the artery as well as the thickness of the wall was measured by tracing the pixel displacements from successive frames during arterial pulsation. The study was conducted on 19 subjects aged 25-40 years. The systolic and diastolic carotid artery lumen diameters and carotid intima-media thickness were calculated as 7.1 ± 0.7, 6.3 ± 0.6 and 0.5 ± 0.05 mm (mean ± standard deviation), respectively. The mean stiffness index (β), Peterson's modulus and Young's modulus of elasticity were 5.2 ± 1.1, 69 ± 15 kPa and 453 ± 99 kPa, respectively. The pixel displacements in tunica intima, tunica media and tunica adventitia were not homogeneous, due to varied macro-constituents such as endothelial tissues, smooth muscle cells, elastin lamina, fibrous tissue and micro-constituents such as collagen, fibroblast and elastin. We found that women have smaller arteries, and the stiffness increased during the systolic phase. PMID:27246916

  4. Correlation of atherosclerotic changes in peripheral arteries with pathological involvement of aortic arch in coronary bypass patients

    Directory of Open Access Journals (Sweden)

    Eshraghi N

    2010-10-01

    Full Text Available "nBackground: A correlation between coronary artery disease (CAD and atherosclerosis of peripheral arteries and the determination of noninvasive indexes for its existence and extent have been sought by many researchers. Some studies report that the intima-media thickness (IMT of peripheral arteries could play this role. This study evaluated the correlation between the IMTs of common carotid and common femoral arteries and the degree of atherosclerosis in aortic arch and to evaluate the severity of CAD in candidates of coronary artery bypass grafting (CABG."n "nMethods: In a cross-sectional analytic-descriptive study, The severity of CAD, the grade of atherosclerosis of the aortic arch, and the IMTs of the common carotid and common femoral arteries were determined."n "nResults: There was a significant weak positive correlation between the IMT of common carotid artery (ρ = 0.193, p = 0.039 and common femoral artery (ρ = 0.206, p = 0.028 with the number of involved carotid vessels; the mean of these two parameters was not significantly different between the three CAD groups. There was not any significant relation between the IMTs of common carotid and common femoral arteries with the severity of atherosclerosis in the aortic arch too. There was not any significant relation between the presences of atherosclerotic plaque in the common carotid or the common femoral arteries with the severity of CAD. The severe atherosclerosis of the aortic arch was significantly higher in patients with three vessel disease."n "nConclusion: According to our results, the IMTs of common carotid and/or common femoral arteries may increase with the severity of CAD; however, these parameters are not a surrogate for predicting the CAD severity.

  5. Consistence study of carotid artery wall thickness by MDCTA and high-frequency ultrasound%MDCTA与高频超声检测颈动脉壁厚度的一致性研究

    Institute of Scientific and Technical Information of China (English)

    洪玮; 赵刚; 王弘; 邱晓明; 王珍

    2012-01-01

    Objective To explore the relevance and consistence between multi-detector row computed tomography angi-ography (MDCTA) and high-frequency ultrasound in measuring carotid artery wall thickness (CAWT) and the intima-media thickness (IMT). Methods Altogether, 64 subjects were prospectively analysed using a 64-detector row CT and high-frequency ultrasound. And they were classified as non-plaque group and plaque group. CAWT and IMT were measured in each patient using MDCTA and ultrasound, respectively. CAWT and IMT were compared and dependency analysed. Bland-Altman statistics was employed to measure the consistency between MDCTA and ultrasound. Results There was not significant difference between CAWT and IMT in the same group ( P > 0. 05). There was a high degree of correlation between all the common carotid artery CAWT and IMT, correlation coefficient was 0. 912 ( P <0. 01). By analysing the Bland-Altman plot, we observed a good consistence between CAWT and IMT with a bias between methods of 0. 029 mm and limit of consistence from 0. 187 mm to 0. 244 mm. Conclusion There was a good consistency between MDCTA and high-frequency ultrasound in the measurement of CAWT and IMT. CAWT can be used as an evaluating indicator of carotid atherosclerosis by MDCTA.%目的 探讨多层螺旋CT血管造影(MDCTA)检测颈总动脉壁厚度(CAWT)与高频超声检测颈总动脉内-中膜层厚度(IMT)的相关性和一致性.方法 应用MDCTA和高频超声对64例患者颈总动脉CAWT和IMT分别进行扫描,分为无斑块组和有斑块组,统计学比较CAWT与IMT的差异性和相关性,用Bland-Altman分析比较两者的一致性.结果 两组患者颈总动脉CAWT与IMT比较无统计学差异(P>0.05),相关性分析呈高度正相关,相关系数为0.912(P<0.O1),Bland-Altman分析存在较好一致性,偏倚为0.029mm,一致性界限为0.187~0.244mm.结论 MDCTA测量颈总动脉CAWT与高频超声测量颈总动脉IMT之间存在高度相关性和较好一致

  6. Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients

    Directory of Open Access Journals (Sweden)

    Katarzyna Janda

    2013-01-01

    Full Text Available Objective. The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD patients and arterial calcification. Materials and Methods. The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis. The examined parameters included common carotid artery intima-media thickness (CCA-IMT, BMI, incidence of diabetes and impaired fasting glucose (IFG, dyslipidemia, hypertension, and 3-year mortality. Plasma levels asymmetric dimethylarginine (ADMA, osteopontin (OPN, osteoprotegerin (OPG, and osteocalcin (OC were also measured. Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using von Kossa method and alizarin red. Results. Calcification of radial artery was significantly associated with higher prevalence of IFG and diabetes (P=0.0004 and older age (P=0.003, as well as higher OPG (P=0.014 and ADMA concentrations (P=0.022. Fasting glucose >5.6 mmol/l (IFG and diabetes significantly predicted vascular calcification in multiple logistic regression. The calcification was also associated with higher CCA-IMT (P=0.006 and mortality (P=0.004; OR for death 5.39 [1.20–24.1] after adjustment for dialysis status and age. Conclusion. Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death.

  7. Juvenile elastic arteries after 28 years of renal replacement therapy in a patient with complete complement C4 deficiency

    Directory of Open Access Journals (Sweden)

    Knoll Florian

    2012-12-01

    Full Text Available Abstract Background Complement activation products are present in atherosclerotic plaques. Recently, binding of complement to elastin and collagen in the aortic wall has been demonstrated, suggesting a role of complement in the development aortic stiffness and atherosclerosis. The definitive role of complement in atherosclerosis and arteriosclerosis, however, remains unclear. Case presentation We here describe a patient with hereditary complete deficiency of complement C4 suffering from Henoch-Schoenlein purpura and on renal replacement therapy for twenty-eight years. The patient had the full range of risk factors for vascular damage such as hypertension, volume overload, hyperphosphatemia and hyperparathyroidism. Despite that, his carotid artery intima media thickness was below the normal range and his pulse wave velocity was normal. In contrast, the patient’s coronary and peripheral muscular arteries were heavily calcified. Conclusion This case supports the hypothesis that complement plays an important role in the development of stiffness of elastic arteries. We speculate that inability to activate complement by the classical or lectin pathways protected the patient from atherosclerosis, arteriosclerosis, stiffening and calcification of the aorta and carotid arteries. Inhibition of complement activation may be a potential target for prophylactic and therapeutic interventions.

  8. Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C – a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Roed T

    2014-01-01

    Full Text Available Torsten Roed,1 Ulrik Sloth Kristoffersen,2 Andreas Knudsen,1,2 Niels Wiinberg,3 Anne-Mette Lebech,1 Thomas Almdal,4 Reimar W Thomsen,5 Andreas Kjær,2 Nina Weis1,61Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark; 2Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 3Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark; 4Steno Diabetes Center, Copenhagen, Denmark; 5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 6Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkObjective: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.Methods: Sixty patients with chronic hepatitis C (mean age 51 years were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.Results: Patients with chronic hepatitis C had more hypertension (40% versus 25%, prevalence ratio [PR] 1.6; 95% confidence interval [CI] 0.9–2.7 and smoked more (53% versus 38%, PR 1.4; 95% CI 0.9–2.1. The two groups had similar body mass index (mean 25.0 versus 25.7 kg/m2, whereas those with chronic hepatitis C had less dyslipidemia (including significantly lower low-density lipoprotein and cholesterol/high-density lipoprotein ratio, higher glycosylated hemoglobin level (mean 6.2 versus 5

  9. [ASSOCIATION BETWEEN DIETARY GLYCEMIC INDEX AND GLYCEMIC LOAD AND INTIMA MEDIA THICKNESS IN A POPULATION AT HIGH CARDIOVASCULAR RISK: A SUBGROUP ANALYSIS IN THE PREDIMED TRIAL].

    Science.gov (United States)

    Goñi Ruiz, Nuria; Martínez González, Miguel Ángel; Salas Salvadó, Jordi; Buil Cosiales, Pilar; Diez Espino, Javier; Martinez Vila, Eduardo; Irimia Sierra, Pablo; Ros Rahola, Emilio; Toledo Atucha, Estefania

    2015-11-01

    Introducción: el grosor de la íntima media carotídea (GIMC) es un conocido marcador de arteriosclerosis precoz y un buen predictor de eventos cardiovasculares futuros. Aunque se ha demostrado que la adhesión a la dieta mediterránea, especialmente si está enriquecida con aceite de oliva virgen extra o frutos secos, tiene efectos beneficiosos sobre los cambios en el GIMC, el papel de los carbohidratos en el desarrollo de la arterioesclerosis sigue siendo controvertido. Objetivo: valorar la relación entre el índice glucémico (IG) o la carga glucémica (CG) de la dieta y el GIMC en una población asintomática con alto riesgo cardiovascular. Métodos: en el marco del estudio PREDIMED (PREvención con Dieta MEDiterránea), se seleccionaron de manera aleatorizada 187 sujetos del centro PREDIMED- NAVARRA. A estos pacientes asintomáticos, pero con alto riesgo cardiovascular, se les realizó una ecografía carotídea basal para determinar su GIMC, y tras un año en el estudio se les repitió la misma medición. Se usó un cuestionario validado de frecuencia de consumo de alimentos (137 ítems) tanto basal como anualmente para obtener el IG y la CG, que fueron categorizados en cuartiles, tras ser ajustados por energía. Mediante modelos multivariables (ANCOVA) se estudió la posible asociación entre el IG o la CG de la dieta y el GIMC o su cambio al año. Resultados: en la población estudiada no se observó una asociación estadísticamente significativa entre el IG o la CG y el GIMC, ni al inicio ni tras un año de seguimiento.

  10. Carotid intima media thickness is associated with plasma lipoprotein-associated phospholipase A(2) mass in nondiabetic subjects but not in patients with type 2 diabetes

    NARCIS (Netherlands)

    Constantinides, Alexander; van Pelt, L. Joost; van Leeuwen, Jeroen J. J.; de Vries, Rindert; Tio, Rene A.; van der Horst, Iwan C. C.; Sluiter, Wim J.; Dullaart, Robin P. F.

    2011-01-01

    Background A recent meta-analysis showed that both plasma lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity independently predict cardiovascular events. Notably, Lp-PLA(2) activity but not mass was found to be a determinant of cardiovascular outcome in type 2 diabetes mellitus.

  11. The CD4/CD8 Ratio is Inversely Associated with Carotid Intima-Media Thickness Progression in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Treatment.

    Science.gov (United States)

    Bernal Morell, Enrique; Serrano Cabeza, José; Muñoz, Ángeles; Marín, Irene; Masiá, Mar; Gutiérrez, Félix; Cano, Alfredo

    2016-07-01

    Inversion of the CD4/CD8 ratio (nonnucleoside reverse transcriptase inhibitors, 6 (6.25%) with integrase inhibitors, 3 (3.12%) with maraviroc, and 2 (2.08%) just with nucleoside reverse transcriptase inhibitors. The mean of ART exposition was 6.9 ± 5.9 years. Twenty six (27%) patients had family history of ischemic heart disease, 51 (53.12%) were smokers, 12 (12.5%) were hypertensive, 4 (4.16%) had type 2 diabetes, 23 (23.9%) had dyslipidemia, and 31 (32.3%) were infected with hepatitis C virus. Baseline cIMT was significantly associated with age (rho = 0.497; p < .001), basal glucemia (rho = 0.323; p = .001), triglycerides (rho = 0.232; p = .023), Framingham risk score (rho = 0.324; p = .001), CD4/CD8 ratio (rho = -0.176; p = .05), and dyslipidemia (0.72 ± 0.16 mm vs. 0.63 ± 0.11 mm; p = .029). In multivariable analysis where cardiovascular risk factor and ART were included, cIMT progression was inversely associated with CD4/CD8 ratio [odds ratio (OR) = 0.283; confidence interval (95% CI) 0.099-0.809; p = .019]. In conclusion, the inversion of CD4/CD8 ratio in treated HIV-infected patients is independently associated with cIMT progression, a marker of coronary heart disease. Therefore, it might be clinically useful as predictor of cardiovascular events. PMID:27005326

  12. Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Troelsen, Lone N; Garred, Peter; Christiansen, Buris;

    2010-01-01

    Patients with systemic lupus erythematosus (SLE) have excess cardiovascular morbidity and mortality due to accelerated atherosclerosis that cannot be attributed to traditional cardiovascular risk factors alone. Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum...

  13. Coronary Artery Calcium, Carotid Artery Wall Thickness and Cardiovascular Disease Outcomes in Adults 70 to 99 Years Old

    OpenAIRE

    Newman, Anne B; Naydeck, Barbara L.; Ives, Diane G.; Boudreau, Robert M.; Sutton-Tyrrell, Kim; O Leary, Daniel H.; Kuller, Lewis H.

    2008-01-01

    Few population studies have evaluated the associations of both coronary artery calcium (CAC) and carotid ultrasound with cardiovascular events, especially in adults > 70 years of age. At the Pittsburgh Field Center of the Cardiovascular Health Study, 559 men and women, mean age 80.2 (SD 4.1) years had CAC score assessed by electron beam computerized tomography scan and common and internal carotid intimal-medial wall thickness (CCA-IMT and ICA-IMT) by carotid ultrasound between 1998−2000 and w...

  14. Association Between Epicardial Fat Thickness and Premature Coronary Artery Disease: A Case Control Study

    OpenAIRE

    Faghihi, Shadi; Vasheghani-Farahani, Ali; Parsaee, Mozhgan; Saedi, Sedigheh; Ghadrdoost, Behshid

    2015-01-01

    Background: The association between epicardial fat thickness (EFT) and premature coronary artery disease (CAD) has not been elaborately studied. Objectives: In the present study, we sought whether such a relationship between EFT and CAD exists. Patients and Methods: Sixty two consecutive subjects, under 50 years of age, who underwent coronary angiography (CAG) with the aspect of CAD, were included in this case control study. They were divided into two groups of 31 subjects, namely CAD (cases)...

  15. Comparison between multi-detector row CT angiography and Doppler ultrasound on detecting carotid artery wall thickness%多层螺旋CT与Doppler超声对颈动脉壁层厚度的对比性研究

    Institute of Scientific and Technical Information of China (English)

    赵刚; 查云飞; 王弘; 洪玮; 邱晓明; 王珍; 肖友梅

    2013-01-01

    Objective To explore the relationship and consistency between multi-detector row computed tomography angiography (MDCTA) and color Doppler ultrasound (CD-US) in measuring carotid artery wall thickness (CAWT) and intima-media thickness (IMT). Methods CAWT and IMT of 38 subjects were measured using MDCTA and CD-US, respectively. Linear correlation analysis was performed to analyze the correlation between the results from CAWT and IMT,and Bland-Altman statistics was employed to analyze the consistency between them. Results The IMT value measured by CD-US was (0.85+0.16) mm, and the CAWT value measured by MDCTA was (0.87.± 0.18) mm (P > 0.05), and there was a high degree of correlation between them (correlation coefficient was 0.958,P< 0.01). An excellent consistency between CAWT and IMT was found by Bland-Altman plot, with a bias of 0.026 mm and the limit of consistency from -0.023 to 0.075. Conclusions There were significant correlation and consistency between MDCTA and CD-US in detecting CAWT and IMT. As a more objective and comprehensive new method, MDCTA can replace CD-US in the evaluation of early carotid atherosclerosis.%目的:探讨多层螺旋CT血管造影(MDCTA)和彩色多普勒超声(CD-US)在检测颈总动脉壁厚度(CAWT)和颈总动脉内膜-中层厚度(IMT)中的相关性和一致性.方法:应用MDCTA和CD-US分别对38例受试者颈总动脉的CAWT和IMT进行检测,用Pearson直线相关分析比较CAWT和IMT的相关性,用Bland-Altman分析比较两者的一致性.结果:MDCTA测量的颈总动脉CAWT为(0.87±0.18)mm,CD-US测量的颈总动脉IMT为(0.85±0.16)mm,两者比较无统计学差异,有高度相关性,相关系数为0.958,P<0.01,Bland-Altman分析两者间存在良好一致性,偏倚为0.026 mm,一致性界限为-0.023 ~ 0.075.结论:MDCTA和CD-US在检测颈总动脉CAWT和IMT时存在良好的相关性和一致性,MDCTA可以替代CD-US,作为一种评价颈动脉早期粥样硬化的更加客观全面的新方法.

  16. Hemoglobin A1c and arterial and ventricular stiffness in older adults.

    Directory of Open Access Journals (Sweden)

    Susan J Zieman

    Full Text Available OBJECTIVE: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE are implicated in this stiffening pathophysiology. We examined the association between HbA(1c, an AGE, with arterial and ventricular stiffness measures in older individuals without diabetes. RESEARCH DESIGN & METHODS: Baseline HbA(1c was measured in 830 participants free of diabetes defined by fasting glucose or medication use in the Cardiovascular Health Study, a population-based cohort study of adults aged ≥ 65 years. We performed cross-sectional analyses using baseline exam data including echocardiography, ankle and brachial blood pressure measurement, and carotid ultrasonography. We examined the adjusted associations between HbA(1c and multiple arterial and ventricular stiffness measures by linear regression models and compared these results to the association of fasting glucose (FG with like measures. RESULTS: HbA(1c was correlated with fasting and 2-hour postload glucose levels (r = 0.21; p<0.001 for both and positively associated with greater body-mass index and black race. In adjusted models, HbA(1c was not associated with any measure of arterial or ventricular stiffness, including pulse pressure (PP, carotid intima-media thickness, ankle-brachial index, end-arterial elastance, or left ventricular mass (LVM. FG levels were positively associated with systolic, diastolic and PP and LVM. CONCLUSIONS: In this sample of older adults without diabetes, HbA(1c was not associated with arterial or ventricular stiffness measures, whereas FG levels were. The role of AGE in arterial and ventricular stiffness in older adults may be better assessed using alternate AGE markers.

  17. Subclinical arterial and cardiac damage in white-coat and masked hypertension.

    Science.gov (United States)

    Wojciechowska, Wiktoria; Stolarz-Skrzypek, Katarzyna; Olszanecka, Agnieszka; Klima, Łukasz; Gąsowski, Jerzy; Grodzicki, Tomasz; Kawecka-Jaszcz, Kalina; Czarnecka, Danuta

    2016-08-01

    The study aimed to compare arterial and echocardiographic parameters in subjects with newly diagnosed masked (MH) or white-coat hypertension (WCH) to subjects with sustained normotension or sustained hypertension, defined according to the 2014 European Society of Hypertension practice guidelines for ambulatory blood pressure (BP) monitoring. We recruited 303 participants (mean age 46.9 years) in a family-based population study. SpaceLabs monitors and oscillometric sphygmomanometers were used to evaluate ambulatory and office BP, respectively. Central pulse pressure (PP) and aortic pulse-wave velocity (PWV) were measured with pulse-wave analysis (SphygmoCor software). Carotid intima-media thickness (IMT) and cardiac evaluation were assessed by ultrasonography. Analysing participants without antihypertensive treatment (115 sustained normotensives, 41 sustained hypertensives, 20 with WCH, 25 with MH), we detected significantly higher peripheral and central PP, PWV, IMT and left ventricular mass index in hypertensive subgroups than in those with sustained normotension. The differences between categories remained significant for peripheral PP and PWV after adjustment for confounding factors, including 24 h systolic and diastolic BP. Participants with WCH and MH, defined according to strict criteria, had more pronounced arterial and heart involvement than normotensive participants. The study demonstrates a high prevalence of these conditions in the general population that deserves special attention from physicians. PMID:26953075

  18. A mathematical model for estimating the axial stress of the common carotid artery wall from ultrasound images.

    Science.gov (United States)

    Soleimani, Effat; Mokhtari-Dizaji, Manijhe; Saberi, Hajir; Sharif-Kashani, Shervin

    2016-08-01

    Clarifying the complex interaction between mechanical and biological processes in healthy and diseased conditions requires constitutive models for arterial walls. In this study, a mathematical model for the displacement of the carotid artery wall in the longitudinal direction is defined providing a satisfactory representation of the axial stress applied to the arterial wall. The proposed model was applied to the carotid artery wall motion estimated from ultrasound image sequences of 10 healthy adults, and the axial stress waveform exerted on the artery wall was extracted. Consecutive ultrasonic images (30 frames per second) of the common carotid artery of 10 healthy subjects (age 44 ± 4 year) were recorded and transferred to a personal computer. Longitudinal displacement and acceleration were extracted from ultrasonic image processing using a block-matching algorithm. Furthermore, images were examined using a maximum gradient algorithm and time rate changes of the internal diameter and intima-media thickness were extracted. Finally, axial stress was estimated using an appropriate constitutive equation for thin-walled tubes. Performance of the proposed model was evaluated using goodness of fit between approximated and measured longitudinal displacement statistics. Values of goodness-of-fit statistics indicated high quality of fit for all investigated subjects with the mean adjusted R-square (0.86 ± 0.08) and root mean squared error (0.08 ± 0.04 mm). According to the results of the present study, maximum and minimum axial stresses exerted on the arterial wall are 1.7 ± 0.6 and -1.5 ± 0.5 kPa, respectively. These results reveal the potential of this technique to provide a new method to assess arterial stress from ultrasound images, overcoming the limitations of the finite element and other simulation techniques. PMID:26563198

  19. Time course of arterial remodelling in diameter and wall thickness above and below the lesion after a spinal cord injury

    OpenAIRE

    Dick H J Thijssen; de Groot, Patricia C. E.; van den Bogerd, Arne; Veltmeijer, Matthijs; Cable, N. Timothy; Green, Daniel J.; Hopman, Maria T. E.

    2012-01-01

    Physical inactivity in response to a spinal cord injury (SCI) represents a potent stimulus for conduit artery remodelling. Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by systemic adaptations due to whole body inactivity. Therefore, we assessed the time course of carotid (i.e. above lesion) and common femoral artery (i.e. below lesion) lumen diameter and wall thickness a...

  20. Increased rate of arterial stiffening with obesity in adolescents: a five-year follow-up study.

    Directory of Open Access Journals (Sweden)

    Frida Dangardt

    Full Text Available BACKGROUND: We prospectively and longitudinally determined the effects of childhood obesity on arterial stiffening and vascular wall changes. Changes in arterial stiffness measured as pulse wave velocity (PWV and vascular morphology of the radial (RA and dorsal pedal arteries (DPA were examined in obese adolescents compared to lean subjects in a 5-year follow-up study. METHODOLOGY/PRINCIPAL FINDINGS: A total of 28 obese subjects and 14 lean controls participated in both baseline (14 years old and follow-up studies. PWV was measured by tonometer (SphygmoCor® and recorded at RA and carotid artery, respectively. Intima thickness (IT, intima-media thickness (IMT and RA and DPA diameters were measured using high-resolution ultrasound (Vevo 770™. Over the course of 5 years, PWV increased by 25% in the obese subjects as compared to 3% in the controls (p = 0.01. Diastolic blood pressure (DBP increased by 23% in the obese subjects as opposed to 6% in controls (p = 0.009. BMI increased similarly in both groups, as did the IT and IMT. The change in PWV was strongly associated to the baseline BMI z -score (r = 0.51, p<0.001, as was the change in DBP (r = 0.50, p = 0.001. CONCLUSIONS/SIGNIFICANCE: During the transition from early to late adolescence, there was a general increase in arterial stiffness, which was aggravated by childhood obesity. The increase in arterial stiffness and DBP after 5 years was closely correlated to the baseline BMI z -score, indicating that childhood obesity has an adverse impact on vascular adaptation.

  1. Assosiation of Epicardial and Pericardial Fat Thickness with Coronary Artery Disease

    Science.gov (United States)

    Ghaderi, Fereshteh; Eshraghi, Ali; Shamloo, Alireza Sepehri; Mousavi, Sareh

    2016-01-01

    Introduction Visceral adipose tissue is a known important risk factor for coronary artery disease (CAD). While some studies have suggested relationship between epicardial fat thickness (EFT) and CAD, there are no adequate studies for pericardial fat thickness (PFT). The aim of this study was to determine the association of EFT and PFT with CAD. Methods This cross-sectional study was conducted on patients who were candidates for elective coronary artery angiography, referred to Emam Reza Hospital, Mashhad, Iran during Jan 2014–2016. Demographic and laboratory data were collected. Transthoracic echocardiography was performed to determine average EFT and PFT at the standard parasternal long-axis view at end-systole for 3 cardiac cycles. SCA was performed on the same day. The patients were divided into two groups: CAD (n=59) and non-CAD (n=41) based on presence or absence of epicardial coronary artery stenosis of > 50%. Chi-square, independent T-test, and receiver operating characteristic (ROC) curve were used by SPSS Version 16 for data analysis. Results One hundred patients (44 women and 56 men) with an average age of 56.4 ± 9.9 years were studied. The two groups were not significantly different in demographic profile and cronary risk factors. While PFT was not significantly different between the two groups, EFT was significantly higher in CAD group (3.0 ± 3.69 vs. 1.2 ± 3.6, p coronary arteries, EFT increased (p <0.0001). Gensini score had a strong correlation with amount of EFT (r = 0.765, p <0.0001). EFT with a cutoff value of 4.25 mm (sensitivity=79%, specificity=68%) was specified in predicting CAD. Conclusion EFT measured by echocardiography can be used as an independent marker to predict CAD. More studies are needed to determine the predictive role of PFT for CAD.

  2. The efficacy of carotid ultrasonography in estimating coronary artery stenosis in patients receiving hemodialysis

    International Nuclear Information System (INIS)

    In patients with dialysis therapy, cardiovascular diseases have a great impact on morbidity and mortality. Because physicians have recently been encountering more patients with diabetes mellitus as well as more elderly patients, the importance of evaluating atherosclerosis has continuously increased. It has been reported that ischemic heart diseases or cerebrovascular diseases can be estimated using non-invasive ultrasonography. In addition, we can also diagnose coronary stenosis using computed tomography more easily than before. In this study, we in vestigated the efficacy of carotid ultrasonography in estimating coronary artery stenosis in patients with hemodialysis. One hundred and eight patients (58 men and 50 women with a mean age of 69±12 years, and a mean dialysis duration of 6.7±6.2 years) were enrolled in this study. We measured the maximum intima-media thickness (max-IMT), the distribution and the properties of plaque and plaque scores at carotid arteries using ultrasonography, and examined the degree of stenosis and the number of stenotic coronary arteries using computed tomography. As the max-IMT or plaque scores increased, the degree of stenosis became significantly more severe and multi-vessel disease was observed with significantly greater frequency. End stage renal disease is one of most significant cardiovascular risk factors. However, it is difficult to diagnose ischemic heart disease correctly in these patients because they sometimes have few symptoms due to diabetes and often show atypical electrocardiograms due to ventricular hypertrophy or electrolyte disorders. In this study, we clearly showed the correlation between atherosclerosis in the carotid arteries and stenosis in the coronary arteries. It is suggested that carotid ultrasonography is useful to estimate coronary artery stenosis, and effective for evaluating the risk of ischemic heart diseases non-invasively in patients with hemodialysis. (author)

  3. Quantitative evaluation of the structure and function of the common carotid artery in hypertriglyceridemic subjects using ultrasound radiofrequency-data technology

    Energy Technology Data Exchange (ETDEWEB)

    Dan, Hai-Jun, E-mail: danhaijun@163.com [Department of Physical Examination, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei (China); Wang, Yan [Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People' s Hospital, Shanghai 200233 (China); Sha, Hai-Jing [Second Department of Geriatrics, The Central Hospital of Handan, Handan 056001, Hebei (China); Wen, Shu-Bin [Department of Physical Examination, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei (China)

    2012-11-15

    Assessment of the properties of blood-vessel walls by ultrasound radiofrequency (RF)-data technology is an innovative technique. We quantitatively evaluated the intima-media thickness (IMT) and arterial elasticity of the common carotid artery (CCA) in asymptomatic subjects with hypertriglyceridemia (HTG) using RF-data technology. Thirty HTG subjects and 30 matched controls were enrolled in the study. The common carotid arterial systolic diameter, diastolic diameter, IMT, carotid distensibility (CD), local pulse wave velocity (PWV{beta}), and stiffness ({beta}) were compared between the two groups, as was the correlation between triglyceride level and the parameters mentioned above. The HTG group had significantly higher values of CCA-IMT compared with the control group (p < 0.001). There were significant differences between the HTG group and controls in terms of higher values of PWV{beta} and {beta}, and lower values of CD (all p < 0.05). No difference was observed in terms of the systolic and diastolic diameter of the CCA (p > 0.05). The level of triglycerides had significant positive correlations with CCA-IMT (r = 0.493, p < 0.001), whereas significant correlations with CD, PWV{beta}, and {beta} were not observed in the HTG group. Ultrasound RF-data technology can be used to non-invasively and quantitatively detect the change in the structure and function of the CCA in asymptomatic HTG subjects for evaluating preclinical atherosclerosis.

  4. 股动脉僵硬度、内中膜厚度和踝臂指数在2 型糖尿病患者下肢血管评价中的价值%Evaluation of peripheral vascular disease with femoral artery wall thickness,stiffness and ankle brachium index in type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    聂芳; 陈慧; 陈斌娟; 车岩; 鲁虹霞; 胥萍

    2009-01-01

    目的 探讨股动脉僵硬度、内中膜厚度和踝臂指数(ABI)评价2型糖尿病患者外周血管疾病(PVD)的价值.方法 151例2型糖尿病患者以有无下肢临床症状分为PVD症状组和无PVD症状组;以ABI值分为ABI异常组(<0.9)和ABI正常组(≥0.9).二维超声测量股动脉内中膜厚度(FA-IMT),彩色流速流量定量技术测量股动脉收缩期及舒张期的内径(Ds及Dd),计算股动脉僵硬度(FA-β).比较FA-IMT和FA-β的组间差异;探讨FA-IMT与FA-β的相关性;多元回归分析FA-IMT、FA-β与PVD症状及ABI减低的相关性.结果 与无PVD症状组比较,PVD症状组FA-IMT、FA-β增高(P<0.01);与ABI正常组相比,ABI异常组FA-IMT、FA-β增高(P<0.01).在PVD症状组中,FA-IMT与FA-β无相关性.多元回归分析显示FA-β与PVD症状密切相关;FA-IMT与ABI减低密切相关.结论 动脉僵硬度在2型糖尿病患者下肢血管疾病评价中有重要作用.%Objective To evaluate the effects of femoral artery wall thickness, stillness and ankle brachium index(ABI) on clinical manifestation of peripheral vascular disease(PVD) in type 2 diabetes mellitus. Methods According to the presence of lower limb and reduced ABI (ABI<0.9), 151 patients with type 2 diabetes were divided into group of patients with and without PVD symptoms, and group of patients with and without reduced ABI. Intima-media thickness of femoral artery (FA-IMT) and stiffness of femoral artery (FA-β) were measured by ultrasound. FA-IMA and FA-β of femoral arteries were compared between group of patients with and without PVD symptoms as well as between group of patients with and without reduced ABI. Correlation between FA-IMT and FA-β was analyzed. Factors affecting symptoms of lower limb and ABI were evaluated by multiple logistic regression analysis. Results FA-IMT and FA-β in group of PVD symptoms were higher than those in group without PVD symptoms. Similarly, patients with reduced ABI had greater FA-IMT and FA-β than those

  5. Examination of the Relationship between Oral Health and Arterial Sclerosis without Genetic Confounding through the Study of Older Japanese Twins.

    Directory of Open Access Journals (Sweden)

    Yuko Kurushima

    Full Text Available Although researchers have recently demonstrated a relationship between oral health and arterial sclerosis, the genetic contribution to this relationship has been ignored even though genetic factors are expected to have some effect on various diseases. The aim of this study was to evaluate oral health as a significant risk factor related to arterial sclerosis after eliminating genetic confounding through study of older Japanese twins.Medical and dental surveys were conducted individually for 106 Japanese twin pairs over the age of 50 years. Maximal carotid intima-media thickness (IMT-Cmax was measured as a surrogate marker of arterial sclerosis. IMT-Cmax > 1.0 mm was diagnosed as arterial sclerosis. All of the twins were examined for the number of remaining teeth, masticatory performance, and periodontal status. We evaluated each measurement related with IMT-Cmax and arterial sclerosis using generalized estimating equations analysis adjusted for potential risk factors. For non-smoking monozygotic twins, a regression analysis using a "between within" model was conducted to evaluate the relationship between IMT-Cmax and the number of teeth as the environmental factor controlling genetic and familial confounding.We examined 91 monozygotic and 15 dizygotic twin pairs (males: 42, females: 64 with a mean (± standard deviation age of 67.4 ± 10.0 years. Out of all of the oral health-related measurements collected, only the number of teeth was significantly related to arterial sclerosis (odds ratio: 0.72, 95% confidence interval: 0.52-0.99 per five teeth. Regression analysis showed a significant association between the IMT-Cmax and the number of teeth as an environmental factor (p = 0.037.Analysis of monozygotic twins older than 50 years of age showed that having fewer teeth could be a significant environmental factor related to arterial sclerosis, even after controlling for genetic and familial confounding.

  6. The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Xingguang Zhang

    2013-01-01

    Full Text Available Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, , type 2 DM patients without cardiovascular complications (group B, , and type 2 DM patients with cardiovascular complications (group C, . The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00–8:00 and 11:00–13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery.

  7. The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus

    Science.gov (United States)

    Zhang, Xingguang; Xu, Xiuping; Jiao, Xiumin; Wu, Jinxiao; Zhou, Shujing; Lv, Xiaofeng

    2013-01-01

    Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, n = 40), type 2 DM patients without cardiovascular complications (group B, n = 56), and type 2 DM patients with cardiovascular complications (group C, n = 92). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00–8:00 and 11:00–13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery. PMID:23936867

  8. Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C

    DEFF Research Database (Denmark)

    Roed, Torsten; Kristoffersen, Ulrik Sloth; Knudsen, Andreas;

    2014-01-01

    /high-density lipoprotein ratio), higher glycosylated hemoglobin level (mean 6.2 versus 5.7, difference of means 0.5; 95% CI 0.3-0.8), and a higher prevalence of metabolic syndrome (28% versus 18%, PR 1.6; 95% CI 0.8-3.0). Increased carotid intima media thickness above the standard 75th percentile was seen more frequently...

  9. Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease

    Institute of Scientific and Technical Information of China (English)

    CHENG Wen-li; KE Yuan-nan; SHI Zai-xiang; WANG Ying; CHEN Li; JU Gao; FAN Shu-ying

    2006-01-01

    Objective: To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (CAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD). Methods: Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally. Results: By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P<0.05). Conclusion; Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.

  10. Resistin might not be a risk factor for carotid artery atherosclerosis in elderly Chinese males

    Institute of Scientific and Technical Information of China (English)

    Hao WANG; Yu-Tang WANG; Li FAN; Yu-Tao GUO; Yang SHI; Tao TAO; Yue-Xiang ZHAO

    2014-01-01

    Objective To investigate the correlation between the serum resistin level and carotid artery atherosclerosis in elderly Chinese males. Methods The study enrolled 235 elderly Chinese males [median age 76 (range 60-97) years] scheduled for ultrasound examination of carotid artery plaque and determination of carotid artery intima-media thickness (CIMT). They were divided into carotid atherosclerotic plaque (CAP) and carotid atherosclerotic plaque-free (CAP-free) groups according to the ultrasound results. Their clinical profiles were col-lected, and the serum resistin and other blood biochemistry levels were determined.Results The CAP group was older and had a thicker mean CIMT than the CAP-free group. However, there was no difference in the serum resistin level between the groups. CIMT was positively correlated with age (r = 0.299,P< 0.001). The serum resistin level was not correlated with CIMT, even after controlling for age. Multiple linear regression analysis revealed that age (β = 0.001,P< 0.001) and body mass index (β = 0.002,P= 0.015) were significantly and posi-tively correlated with the mean CIMT. Only age [odds ratio (OR): 1.159; 95% confidence interval (CI): 1.078-1.183,P< 0.001] was associ-ated with the presence of carotid artery atherosclerotic plaque. The serum resistin level was not correlated with the mean CIMT or associated with the presence of carotid artery atherosclerotic plaque.Conclusion The results suggest that resistin might not be a risk factor for atherosclerosis in elderly Chinese males.

  11. Modelling the layer-specific three-dimensional residual stresses in arteries, with an application to the human aorta.

    Science.gov (United States)

    Holzapfel, Gerhard A; Ogden, Ray W

    2010-05-01

    This paper provides the first analysis of the three-dimensional state of residual stress and stretch in an artery wall consisting of three layers (intima, media and adventitia), modelled as a circular cylindrical tube. The analysis is based on experimental results on human aortas with non-atherosclerotic intimal thickening documented in a recent paper by Holzapfel et al. (Holzapfel et al. 2007 Ann. Biomed. Eng. 35, 530-545 (doi:10.1007/s10439-006-9252-z)). The intima is included in the analysis because it has significant thickness and load-bearing capacity, unlike in a young, healthy human aorta. The mathematical model takes account of bending and stretching in both the circumferential and axial directions in each layer of the wall. Previous analysis of residual stress was essentially based on a simple application of the opening-angle method, which cannot accommodate the three-dimensional residual stretch and stress states observed in experiments. The geometry and nonlinear kinematics of the intima, media and adventitia are derived and the associated stress components determined explicitly using the nonlinear theory of elasticity. The theoretical results are then combined with the mean numerical values of the geometrical parameters and material constants from the experiments to illustrate the three-dimensional distributions of the stretches and stresses throughout the wall. The results highlight the compressive nature of the circumferential stress in the intima, which may be associated with buckling of the intima and its delamination from the media, and show that the qualitative features of the stretch and stress distributions in the media and adventitia are unaffected by the presence or absence of the intima. The circumferential residual stress in the intima increases significantly as the associated residual deformation in the intima increases while the corresponding stress in the media (which is compressive at its inner boundary and tensile at its outer boundary

  12. The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots

    OpenAIRE

    Jovelić Aleksandra; Rađen Slavica; Hajduković Zoran; Čanji Tibor

    2009-01-01

    Background/Aim. Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP) and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pil...

  13. Epicardial Adipose Tissue Thickness Is an Independent Predictor of Critical and Complex Coronary Artery Disease by Gensini and Syntax Scores.

    Science.gov (United States)

    Erkan, Aycan Fahri; Tanindi, Asli; Kocaman, Sinan Altan; Ugurlu, Murat; Tore, Hasan Fehmi

    2016-02-01

    Epicardial adipose tissue thickness is associated with the severity and extent of atherosclerotic coronary artery disease. We prospectively investigated whether epicardial adipose tissue thickness is related to coronary artery disease extent and complexity as denoted by Gensini and Syntax scores, and whether the thickness predicts critical disease. After performing coronary angiography in 183 patients who had angina or acute myocardial infarction, we divided them into 3 groups: normal coronary arteries, noncritical disease (≥1 coronary lesion with Syntax scores by reviewing the angiograms. Mean thicknesses were 4.3 ± 0.9, 5.2 ± 1.5, and 7.5 ± 1.9 mm in patients with normal coronary arteries, noncritical disease, and critical disease, respectively (P 7 mm), mean Gensini scores were 4.1 ± 5.5, 19.8 ± 15.6, and 64.9 ± 32.4, and mean Syntax scores were 4.7 ± 5.9, 16.6 ± 8.5, and 31.7 ± 8.7, respectively (both P Syntax, r =0.825, P Syntax scores, and it predicts critical coronary artery disease.

  14. Breast arterial calcification and risk of carotid atherosclerosis: Focusing on the preferentially affected layer of the vessel wall

    Energy Technology Data Exchange (ETDEWEB)

    Sedighi, Nahid, E-mail: nsedighi@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Radmard, Amir Reza, E-mail: radmard@ams.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Radmehr, Ali, E-mail: radmehr@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Hashemi, Pari, E-mail: phtums@yahoo.com [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Hajizadeh, Abdolmahmoud, E-mail: mroomezi@yahoo.com [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Taheri, Amir Pejman Hashemi, E-mail: hashemip@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of)

    2011-08-15

    Objective: To assess the relationship between breast arterial calcification (BAC) detected on screening mammography and atherosclerosis of carotid arteries considering the most likely involved layer of the arterial wall. Materials and methods: A total of 537 consecutive women who underwent screening mammography were enrolled in this study. Seventy-nine subjects having BAC, aged 46-75 years, and 125 age-matched controls from those without BAC were selected for ultrasound examination of carotid arteries assessing intima-media thickness (IMT) and plaque presence. Participants were divided into three groups of risk including, low-risk: IMT < 0.6 mm without plaque, medium-risk: 0.6 mm {<=} IMT {<=} 0.8 mm without plaque and high-risk: IMT > 0.8 mm and/or plaque. Risk factors for atherosclerosis were obtained from medical records for independent effects. Results: BAC was present in 14.7% of mammograms. According to multivariable logistic regression analyses, significant association was identified between the carotid atherosclerosis risk and presence of BAC. Compared to women with IMT < 0.6 mm, those with 0.6 mm {<=} IMT{<=} 0.8 mm and IMT > 0.8 mm had OR (95% CI) of 4.88 (1.47-16.16) and 23.36 (4.54-120.14), respectively. The OR (95% CI) for carotid plaque was 3.13 (1.3-7.57). There was no interaction between IMT category and plaque. Significant associations were also detected with postmenopausal duration (P = 0.02) and hypertension (P = 0.004). Conclusion: The risk of carotid atherosclerosis increases with the presence of BAC. Women with BAC are more likely to have thicker IMT than plaque, which could be attributed to the preferentially similar affected layer of media causing thick IMT rather than plaque.

  15. An abdominal aortic calcification as a RISK FACTOR FOR cardio -cerebral events in patients with peripheral arterial

    Directory of Open Access Journals (Sweden)

    V. A. Zelinskiy

    2012-01-01

    Full Text Available Background. The patients with abdominal aortic calcification have a high risk of cardiocerebral events, but the pathways of them have not been reported so far. The goal of our study was to assess the structure and function of myocardium and to determine the morphological features of carotid artery atherosclerosis in patients with abdominal aortic calcification.Materials and methods. A total of 167 executive patients with peripheral arterial disease were enrolled in study. The study group included 85 patients with abdominal aortic calcification (men – 95.3 %; age median was – 66.6 ± 12. Control group included 82 patients without objective signs of abdominal aortic calcification. Abdominal aortic calcification was detected by CT imaging. All patients have undergone echocardiography and duplex scanning of carotid arteries.Results. Prevalence and severity of ischemic heart disease and cerebrovascular disease were statistically significant higher in patients with abdominal aortic calcification (91.7, 65.8 % vs. 67, 37.3 % (р < 0.01. We have found statistically significant differences between groupsin heart structure and function. A high left ventricular wall thickness (р < 0.01, left atrium dilation (р < 0.01 and enhanced of left ventricular mass (р < 0.05, ejection fraction reduction (р < 0.05 and more common diastolic dysfunction (р < 0.05 were determined inpatients with abdominal aortic calcification. An intima-media thickness of the common carotid artery was significantly higher in study group patients (1.38 ± 0.07 mm vs. 1.14 ± 0.06 mm (р < 0.001.Conclusion. Our findings suggested that abdominal aortic calcification is main reason of hypertrophy and dilation in the left heart due to enhanced peripheral resistance. Hypertrophy and dilation in the left heart is provided a high risk of cardiovascular events in patients withabdominal aortic calcification.

  16. Effects of Smoking and Cessation on Subclinical Arterial Disease: A Substudy of a Randomized Controlled Trial

    Science.gov (United States)

    Johnson, Heather M.; Piper, Megan E.; Baker, Timothy B.; Fiore, Michael C.; Stein, James H.

    2012-01-01

    Background The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial. Methodology/Principal Findings Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt), intermittently abstinent (reported smoking at one of the three time points), or smoked continuously (reported smoking at all three time points). The primary endpoint was the absolute change (mm) in carotid intima-media thickness (ΔCIMTmax) before randomization and 3 years after the target quit date. Pearson correlations were calculated and multivariable regression models (controlling for baseline CIMTmax and research site) were analyzed. Among 795 subjects (45.2±10.6 years old, 58.5% female), 189 (23.8%) were continuously abstinent, 373 (46.9%) smoked continuously, and 233 (29.3%) were abstinent intermittently. There was a greater increase in carotid intima-media thickness among subjects who were continuously abstinent than among those who smoked continuously (p = 0.020), but not intermittently (p = 0.310). Antihypertensive medication use (p = 0.001) and research site (p<0.001) independently predicted ΔCIMTmax – not smoking status. The greatest increase in carotid intima-media thickness among continuous abstainers was related to increases in body-mass index (p = 0.043). Conclusions/Significance Smoking status did not independently predict ΔCIMTmax; increasing body-mass index and antihypertensive medication use were the most important independent predictors. The rapid reduction in cardiovascular disease events

  17. Effects of smoking and cessation on subclinical arterial disease: a substudy of a randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Heather M Johnson

    Full Text Available BACKGROUND: The mechanisms by which smoking cessation reduces cardiovascular disease risk are unclear. We evaluated longitudinal changes in carotid intima-media thickness among current smokers enrolled in a prospective, randomized smoking cessation clinical trial. METHODOLOGY/PRINCIPAL FINDINGS: Subjects were enrolled in a randomized, double-blind, placebo-controlled trial of 5 smoking cessation pharmacotherapies and underwent carotid ultrasonography with carotid intima-media thickness measurement. Subjects were classified as continuously abstinent (biochemically confirmed abstinence at 6 months, 1 year, and 3 years post-quit attempt, intermittently abstinent (reported smoking at one of the three time points, or smoked continuously (reported smoking at all three time points. The primary endpoint was the absolute change (mm in carotid intima-media thickness (ΔCIMT(max before randomization and 3 years after the target quit date. Pearson correlations were calculated and multivariable regression models (controlling for baseline CIMT(max and research site were analyzed. Among 795 subjects (45.2 ± 10.6 years old, 58.5% female, 189 (23.8% were continuously abstinent, 373 (46.9% smoked continuously, and 233 (29.3% were abstinent intermittently. There was a greater increase in carotid intima-media thickness among subjects who were continuously abstinent than among those who smoked continuously (p = 0.020, but not intermittently (p = 0.310. Antihypertensive medication use (p = 0.001 and research site (p<0.001 independently predicted ΔCIMTmax--not smoking status. The greatest increase in carotid intima-media thickness among continuous abstainers was related to increases in body-mass index (p = 0.043. CONCLUSIONS/SIGNIFICANCE: Smoking status did not independently predict ΔCIMT(max; increasing body-mass index and antihypertensive medication use were the most important independent predictors. The rapid reduction in cardiovascular disease events observed

  18. Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors

    Directory of Open Access Journals (Sweden)

    Morgan Timothy

    2005-03-01

    Full Text Available Abstract Background Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins. Methods and Results We examine two separate systems of criteria that have been proposed to define surrogate endpoints, based on clinical and statistical arguments. We use published results and a formal meta-analysis to evaluate whether progression of carotid IMT meets these criteria for HMG-CoA reductase inhibitors (statins. IMT meets clinical-based criteria to serve as a surrogate endpoint for cardiovascular events in statin trials, based on relative efficiency, linkage to endpoints, and congruency of effects. Results from a meta-analysis and post-trial follow-up from a single published study suggest that IMT meets established statistical criteria by accounting for intervention effects in regression models. Conclusion Carotid IMT progression meets accepted definitions of a surrogate for cardiovascular disease endpoints in statin trials. This does not, however, establish that it may serve universally as a surrogate marker in trials of other agents.

  19. A Data Mining Approach for Cardiovascular Disease Diagnosis Using Heart Rate Variability and Images of Carotid Arteries

    Directory of Open Access Journals (Sweden)

    Hyeongsoo Kim

    2016-06-01

    Full Text Available In this paper, we proposed not only an extraction methodology of multiple feature vectors from ultrasound images for carotid arteries (CAs and heart rate variability (HRV of electrocardiogram signal, but also a suitable and reliable prediction model useful in the diagnosis of cardiovascular disease (CVD. For inventing the multiple feature vectors, we extract a candidate feature vector through image processing and measurement of the thickness of carotid intima-media (IMT. As a complementary way, the linear and/or nonlinear feature vectors are also extracted from HRV, a main index for cardiac disorder. The significance of the multiple feature vectors is tested with several machine learning methods, namely Neural Networks, Support Vector Machine (SVM, Classification based on Multiple Association Rule (CMAR, Decision tree induction and Bayesian classifier. As a result, multiple feature vectors extracted from both CAs and HRV (CA+HRV showed higher accuracy than the separative feature vectors of CAs and HRV. Furthermore, the SVM and CMAR showed about 89.51% and 89.46%, respectively, in terms of diagnosing accuracy rate after evaluating the diagnosis or prediction methods using the finally chosen multiple feature vectors. Therefore, the multiple feature vectors devised in this paper can be effective diagnostic indicators of CVD. In addition, the feature vector analysis and prediction techniques are expected to be helpful tools in the decisions of cardiologists.

  20. Carotid artery wall thickness and ischemic symptoms: evaluation using multi-detector-row CT angiography

    Energy Technology Data Exchange (ETDEWEB)

    Saba, Luca; Caddeo, Giancarlo; Mallarini, Giorgio [Azienda Ospedaliero Universitaria Polo di Monserrato, Department of Radiology, Cagliari (Italy); Sanfilippo, Roberto; Montisci, Roberto [Azienda Ospedaliero Universitaria Polo di Monserrato, Department of Vascular Surgery, Cagliari (Italy); Pascalis, Luigi [Azienda Ospedaliero Universitaria Polo di Cagliari, Division of II Internal Medicine, Cagliari (Italy)

    2008-09-15

    The purpose of this study was to determine if carotid artery wall thickness (CAWT) studied by using multi-detector-row CT angiography (MDCTA) can be considered an effective parameter predictive of increased risk of stroke. A total of 217 patients were retrospectively studied by using MDCTA. In all patients CAWT was measured with an internal digital caliper. Continuous data were described as the mean value {+-} standard deviation (SD), and they were compared with Student's t-test. Scatter plots to determine interobserver agreement were performed, and correlation coefficient was calculated with Pearson statistics. A P value <0.05 was considered to mean statistical significance. Measurements of the distal common CAWT ranged from 0.5 to 1.6 mm. In the patient group without stroke, average CAWT was 0.82 mm (0.22 SD), whereas in patient group with stroke it was 1.096 mm (0.21 SD). CAWT in patients without stroke showed statistical difference (P<0.0001) when compared to patients with stroke. By using a threshold of 1 mm, an important statistical association between thick CAWT and stroke was found (P<0.0001). In fact, patients with {>=}1 mm CAWT had stroke with an odds ratio of 8.16 when compared with patients with <1 mm CAWT. Resulting data suggested that an increased CAWT is an indicator for risk of stroke. This parameter should be considered in addition to other well-known risk factors such as diabetes, hypertension, smoking, and dyslipidemia. (orig.)

  1. Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive

    Directory of Open Access Journals (Sweden)

    Recio-Rodriguez Jose I

    2012-02-01

    Full Text Available Abstract Background Our aim was to analyze the relationship between abdominal obesity and general obesity, with subclinical atherosclerosis, arterial stiffness and wave reflection in healthy, diabetics and hypertensive subjects. Methods A cross-sectional descriptive study was made of 305 individuals (diabetics 32.8%, hypertensive subjects 37.0% and healthy individuals 30.2%. Measurements: Body mass index (BMI, waist circumference (WC, body fat percentage (BFP and waist/height ratio (WHtR. Arterial stiffness was assessed according to pulse wave velocity (PWV, intima-media thickness of the common carotid artery (C-IMT, augmentation index (central and peripheral, ankle-brachial index (ABI, and central and peripheral pulse pressure. Results WC and WHtR showed a positive correlation to PWV and C-IMT in the studied groups. After adjusting for age, gender, high sensitivity c-reactive protein, serum glucose and the presence of diabetes, hypertension, smoking, dyslipidemia, antidiabetic drugs, lipid-lowering drugs, and atherosclerotic plaques, it was seen that for every 0.1 point increase in WHtR, and for every cm increase in WC, the PWV increased 0.041 and 0.029 m/sec, and C-IMT increased 0.001 mm and 0.001 mm, respectively. Conclusions The measures of abdominal obesity (WHtR and WC correlates better than BMI and BFP with arterial stiffness evaluated by PWV, and with subclinical atherosclerosis evaluated by C-IMT, independently of the presence of diabetes or hypertension. Trial Registration Clinical Trials.gov Identifier: NCT01325064

  2. The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots

    Directory of Open Access Journals (Sweden)

    Jovelić Aleksandra

    2009-01-01

    Full Text Available Background/Aim. Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pilots as representatives of healthy men. Methods. We studied 161 military pilots (age 38 ± 6 years free of cardiovascular disease and diabetes mellitus. Traditional and metabolic risk factors were determined. Plasma CRP was measured by immunonephelometry. The common carotid artery intima-media thickness was measured by ultrasonography in the posterior wall of both common carotid arteries. Results. A total of 66.5% subjects had common carotid artery intima-media thickness > 0.9 mm (p < 0.01. The mean CRP plasma concentration was significantly higher in the subjects with common carotid artery intima- media thickness > 0.9 mm than in those with common carotid artery intima-media thickness ≤ 0.9 mm. In a simple regression analysis age adjusted CRP was associated with common carotid artery intima-media thickness (β = 0.285, p < 0.01, and only high density lipoprotein cholesterol was not associated with common carotid artery intima-media thickness. The association between CRP and common carotid artery intima-media thickness remained highly significant after controlling for body mass index, blood pressure, total cholesterol, low density lipoprotein cholesterol, triglycerides, glycosylated hemoglobin and smoking (p < 0.01. Controlling for glucose, triglycerides to high density lipoprotein cholesterol ratio, and total cholesterol to high density lipoprotein cholesterol ratio resulted in some reduction in the strength of the association, but including waist

  3. Utilization of a global data grid repository in CAD assessment of carotid wall thickness

    Science.gov (United States)

    Gutierrez, Marco A.; Lee, Jasper; Zhou, Zheng; Pilon, Paulo E.; Lage, Silvia G.

    2007-03-01

    A CAD method of calculating wall thickness of carotid vessels addresses the time-consuming issue of using B-mode ultrasound as well as inter- and intra-observer variability in results. Upon selection of a region-of-interest and filtering of a series of ultrasound carotid images, the CAD is able to measure the geometry of the lumen and plaque surfaces using a least-square fitting of the active contours during systole and diastole. To evaluate the approach, ultrasound image sequences from 30 patients were submitted to the procedure. The images were stored on an international data grid repository that consists of three international sites: Image Processing and Informatics (IPI) Laboratory at University of Southern California, USA; InCor (Heart Institute) at Sao Paulo, Brazil, and Hong Kong Polytechnic University, Hong Kong. The three chosen sites are connected with high speed international networks including the Internet2, and the Brazilian National Research and Education Network (RNP2). The Data Grid was used to store, backup, and share the ultrasound images and analysis results, which provided a large-scale and a virtual data system. In order to study the variability between the automatic and manual definition of artery boundaries, the pooled mean and the standard deviation for the difference between measurements of lumen diameter were computed. The coefficient of variation and correlation were also calculated. For the studied population the difference between manual and automatic measurement of the lumen diameter (LD) and intima-media-thickness (IMT) were 0.12 +/-0.10 and 0.09+/- 0.06, respectively.

  4. Cross-Sectional Elasticity Imaging of Arterial Wall by Comparing Measured Change in Thickness with Model Waveform

    Science.gov (United States)

    Tang, Jiang; Hasegawa, Hideyuki; Kanai, Hiroshi

    2005-06-01

    For the assessment of the elasticity of the arterial wall, we have developed the phased tracking method [H. Kanai et al.: IEEE Trans. Ultrason. Ferroelectr. Freq. Control 43 (1996) 791] for measuring the minute change in thickness due to heartbeats and the elasticity of the arterial wall with transcutaneous ultrasound. For various reasons, for example, an extremely small deformation of the wall, the minute change in wall thickness during one heartbeat is largely influenced by noise in these cases and the reliability of the elasticity distribution obtained from the maximum change in thickness deteriorates because the maximum value estimation is largely influenced by noise. To obtain a more reliable cross-sectional image of the elasticity of the arterial wall, in this paper, a matching method is proposed to evaluate the waveform of the measured change in wall thickness by comparing the measured waveform with a template waveform. The maximum deformation, which is used in the calculation of elasticity, was determined from the amplitude of the matched model waveform to reduce the influence of noise. The matched model waveform was obtained by minimizing the difference between the measured and template waveforms. Furthermore, a random error, which was obtained from the reproducibility among the heartbeats of the measured waveform, was considered useful for the evaluation of the reliability of the measured waveform.

  5. Assessment of normal and atherosclerotic arterial wall thickness with an intravascular ultrasound imaging catheter.

    OpenAIRE

    Mallery, JA; Tobis, JM; Griffith, J.; Gessert, J; McRae, M; Moussabeck, O; Bessen, M; Moriuchi, M; Henry, WL

    1990-01-01

    A prototype intravascular ultrasound imaging catheter with a 20 MHz transducer was used to obtain 59 cross-sectional images in 14 segments of human atherosclerotic arteries. Three distinct components of the arterial wall were visualized on the ultrasound images: a highly reflective intima, an echolucent media, and a moderately reflective adventitia. Images were obtained at 1 mm increments in vitro and were compared with histologic sections at the same levels. Measurements of the arterial laye...

  6. 彩色多普勒超声评价颈总动脉壁厚度及血管阻力指数与代谢综合征患者急性心肌梗死发生的关系%Correlation between wall thickness or resistance index of common carotid artery and acute myocardial infarction development in patients with metabolic syndrome

    Institute of Scientific and Technical Information of China (English)

    廖继安; 孙政; 沈丹; 张化诚

    2011-01-01

    Objective To evaluate the efficacy of acute myocardial infarction (AMI) prediction in patients with metabolic syndrome ( MS) by color Doppler ultrasound. Methods Of all 102 cases, MS patients with AMI were 57 cases and 45 cases had no AMI. Intima-media thickness ( IMT) , adventitial thickness ( AT) and resistance index ( RI) of common carotid artery ( CCA) were measured in 102 patients with MS by color Doppler ultrasound. The relationships between CCA indexes and AMI development as well as AMI risk factors were analyzed. Results IMT and AT were increased in MS patients with AMI compared with those without AMI. There was significant correlation between development of AMI and IMT or AT (P < 0. 01, P <0. 05). The detection rates of IMT and AT were greater than RI in AMI group (P <0. 001) , while that of IMT was the greatest in the non-AMI group (P<0. 005). In AMI patients, IMT was correlated with systolic blood pressure, 2-hour postprandial blood sugar and fibrinogen ( FIB) positively correlated (r = 0. 830, r = 0. 835, r =0. 753 , respectively,P <0. 001) with high density lipoprotein cholesterol ( HDL-C)negatively (r = - 0. 840,P <0. 001). AT was positively correlated with FIB (r =0. 828 ,P <0. 001) , and negatively with HDL-C (r = - 0. 798 ,P <0. 001). RI was negatively correlated with HDL-C ( r = - 0. 671 ,P<0. 001) . Conclusion IMT and AT measurement in MS patients could increase accuracy of AMI incidence prediction,and provide ultra-acoustic evidence for early prevention and treatment measures.%目的 应用彩色多普勒超声评价颈总动脉壁厚度及血管阻力在预测代谢综合征(MS)患者急性心肌梗死(AMI)发生中的作用.方法 102例MS患者中合并AMI者57例,未合并AMI者45例.彩色多普勒超声观察颈总动脉(CCA)内膜-中层厚度(IMT)、外膜厚度(AT)及阻力指数(RI),分析评价上述指标与MS患者AMI发生的关系及与其他AMI危险因素间的相关性.结果 MS合并AMI组较MS

  7. Relationship between Retinal Vascular Caliber and Coronary Artery Disease in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD

    Directory of Open Access Journals (Sweden)

    Marmor Alon

    2013-08-01

    Full Text Available Objective: To evaluate the relationship between retinal vascular caliber and cardiovascular disease in non-alcoholic fatty liver disease (NAFLD patients without diabetes and hypertension. Methods: Intention to treat study of individuals who underwent cardiac computed tomography (CT during a two year period. Coronary artery disease (CAD was defined as stenosis of >50% in at least one major coronary artery. Liver and spleen density were measured by abdominal (CT; intima-media thickness (IMT by Doppler ultrasound; retinal artery and vein diameter by colored-retinal angiography; and metabolic syndrome by ATP III guidelines. Serum biomarkers of insulin resistance, inflammation, and oxidant-antioxidant status were assessed. Results: Compared with 22 gender and age matched controls, the 29 NAFLD patients showed higher prevalence of coronary plaques (70% vs. 30%, p < 0.001, higher prevalence of coronary stenosis (30% vs. 15%, p < 0.001, lower retinal arteriole-to-venule ratio (AVR (0.66 ± 0.06 vs. 0.71 ± 0.02, p < 0.01, higher IMT (0.98 ± 0.3 vs. 0.83 ± 0.1, p < 0.04, higher carotid plaques (60% vs. 40%, p < 0.001, higher homeostasis model assessment of insulin resistance (HOMA (4.0 ± 3.4 vs. 2.0 ± 1.0, p < 0.005, and higher triglyceride levels (200 ± 80 vs. 150 ± 60, p < 0.005 than controls. Multivariate analysis showed fatty liver (OR 2.5; p < 0.01, IMT (OR 2.3 p < 0.001, and retinal AVR ratio (OR 1.5, p < 0.01 to be strongly associated with CAD independent of metabolic syndrome (OR 1.2, p < 0.05. Conclusions: Patients with smaller retinal AVR (<0.7 are likely to be at increased risk for CAD and carotid atherosclerosis in patients with NAFLD even without hypertension or diabetes.

  8. Carotid thin fluttering bands: A new element of arterial wall remodelling? An ultrasound study.

    Science.gov (United States)

    Costanzo, Luca; Sole, Andrea; Tamburino, Corrado; Di Pino, Luigi

    2015-10-01

    Carotid artery ultrasound is a non-invasive and reproducible technique used for early atherosclerotic assessment. Intimal flap has been described in the presence of dissection or mobile plaque rupture, however presence of carotid thin fluttering bands (TFBs) have not been described yet. To investigate frequency, characteristics and impact of TFBs in carotid lumen of patients who underwent carotid ultrasound scan (CUS). 3341 patients were admitted from January 2009 to January 2014. Patients with history of cerebral ischemia (CI) were excluded. In the cases in which TFBs were observed, a 3-months clinical and CUS follow-up (FU) was performed. TFBs were found in 71 patients (2.1%). The mean age was 63.41 ± 11.20 years (range 42-89). All patients showed a mean increase in intima-media thickness. We identified two subgroups: in 22 patients the TFB was related to a carotid plaque while in 49 no carotid plaque was found. TFB mostly originated in the carotid bulb (88.7%) and was similarly located in carotid arteries (49.3% left-side and 50.7% right-side). CUS and clinical FU were available for all patients (mean duration 25.34 months, median 19). CI occurred in none of the patients. TFB disappeared in 13 patients (18.3%) with no sign or symptoms of CI. In 3 of 49 patients without carotid plaque (6.1%), progressive thickening beneath TFB was observed. TFB is a rare finding. Longer FU is needed to evaluate its prognosis. To date, the pathophysiology is unknown, however it could be related to vascular remodeling. PMID:26179862

  9. Arterial Structure and Function in Ambulatory Adolescents with Cerebral Palsy Are Not Different from Healthy Controls

    Directory of Open Access Journals (Sweden)

    Audra A. Martin

    2012-01-01

    Full Text Available Physical inactivity in youth with cerebral palsy (CP places them at increased risk of developing cardiovascular disease. The current study assessed indices of arterial health in adolescents with CP, classified as levels I-II of the Gross Motor Function Classification System (GMFCS (n=11, age 13.2±2.1 yr, in comparison to age- and sex-matched controls (n=11, age 12.4±2.3 yr. Groups were similar in anthropometric measurements, resting blood pressures, and heart rates. There were no group differences in brachial flow-mediated dilation (11.1±7.8 versus 6.1±3.6, carotid intima-media thickness (0.42±0.04 versus 0.41±0.03 mm, and distensibility (0.008±0.002 versus 0.008±0.002 mmHg or central (4.3±0.6 versus 4.1±0.9 m/s and peripheral pulse wave velocity (7.1±1.7 versus 7.6±1.1 m/s; CP versus healthy controls, respectively. Vigorous intensity physical activity (PA was lower in the CP group (CP: 38±80 min versus controls: 196±174 min; groups were similar in light and moderate intensity PA levels. Arterial health of ambulatory youth with CP is not different from a control group despite lower vigorous PA levels. Similar studies need to examine individuals with more pronounced mobility limitations (GMFCS level III–V.

  10. 单纯性肥胖儿童颈动脉参数%Correlation research on carotid artery parameter among the children with simple obesity

    Institute of Scientific and Technical Information of China (English)

    邬盛鑫; 马受良; 马君义; 郭春家; 杨巧玲; 方新林; 凌菊; 张平

    2011-01-01

    velocity and resistance index did not differ significantly ( P >0.05 ).The intima-media thickness increased with age, and there was no difference in carotid artery diameter ( P > 0.05).Conclusion BMI, blood pressure, high-density lipoprotein are correlated with carotid artery diameter, blood flow velocity and intima-media thickness.

  11. Obesity and carotid artery remodeling

    DEFF Research Database (Denmark)

    Kozakova, M; Palombo, C; Morizzo, C;

    2015-01-01

    BACKGROUND/OBJECTIVE: The present study tested the hypothesis that obesity-related changes in carotid intima-media thickness (IMT) might represent not only preclinical atherosclerosis but an adaptive remodeling meant to preserve circumferential wall stress (CWS) in altered hemodynamic conditions...... and CCA LD (266 healthy subjects with wide range of body weight (24-159 kg)); (B) longitudinal associations between CCA LD and 3-year IMT progression rate (ΔIMT; 571 healthy non-obese subjects without increased cardiovascular (CV) risk); (C) the impact of obesity on CCA geometry and CWS (88 obese subjects...... without CV complications and 88 non-obese subjects matched for gender and age). RESULTS: CCA LD was independently associated with SV that was determined by body size. In the longitudinal study, baseline LD was an independent determinant of ΔIMT, and ΔIMT of subjects in the highest LD quartile...

  12. Correlating cognitive impairment with carotid atherosclerosis and carotid artery stenosis in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Yamei Cai; Xiaoming Wang; Xin Liu; Liting Cao

    2008-01-01

    BACKGROUND: Studies have demonstrated that carotid atherosclerosis and carotid artery stenosis are closely associated with cognitive impairment in patients with and without clinically evident cerebrovascular disease.OBJECTIVE: To investigate the correlation between the degree of pathological changes in carotid atherosclerosis, carotid artery stenosis, and cognitive impairment in patients with acute cerebral infarction through the use of color Doppler imaging.DESIGN, TIME AND SETTING: The present concurrent, non-randomized, controlled experiment was performed at the Departments of Neurology and Ultrasound, Affiliated Hospital of North Sichuan Medical College between November 2006 and August 2007.PARTICIPANTS: Fifty-five patients with cerebral infarction, consisting of 35 males and 20 females, aged 50-82 years, were admitted to the hospital between November 2006 and August 2007 and recruited for this study, An additional 30 subjects consisting of 18 males and 12 females, aged 47-78 years, that concurrently received a health examination at the same hospital, were also included as normal controls.METHODS: Intima-media thickness (IMT), plaque shape, size, and echo intensity of all subjects were detected by color Doppler flow imaging. Assessment criteria: IMT > 1.0 mm was considered to be intimal thickening, and IMT > 1.2 mm was determined to be formed atherosclerotic plaques. In the position of the largest plaque, the degree of carotid artery stenosis was determined by the following formula:(1-cross-sectional area of residual vascular luminal area/vascular cross-sectional area) x 100%. Less than 30% exhibited mild stenosis, 30%-40% moderate stenosis, and > 50% severe stenosis.MAIN OUTCOME MEASURES: IMT and the degree of carotid artery stenosis were evaluated by color Doppler flow imaging. The Mini-Mental State Examination (MMSE), as well as the clinical memory scale,was compared between patients with cerebral infarction and normal controls.RESULTS: In the cerebral

  13. [Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].

    Science.gov (United States)

    Ragino, Iu I; Cherniavskiĭ, A M; Polonskaia, Ia V; Volkov, A M; Kashtanova, E V; Tsymbal, S Iu; Polovnikova, E M

    2012-01-01

    Concentrations of tumor necrosis factor, interleukin 1- and its receptor antagonist, IL-6, IL-8, IL-18, IL-2, ligand of CD40 receptor (CD40L), high sensitive C-reactive protein (hsCRP), monocyte chemotactic protein -1, endothelial monocyte activating protein II, adhesive molecules (sICAM-1 and sVCAM-1), matrix metalloproteinase (MMP-3, MMP-7, MMP-9), tissue inhibitor of metalloproteinase (TIMP-1) and endothelin-1 were studied in blood and in coronary artery intima/media of men with coronary atherosclerosis without acute coronary syndrome. Blood levels of hsCRP, IL-8, IL-6 and CD40L were higher, while blood levels of sVCAM and TIMP-1 were lower in men with prevalence of unstable atherosclerotic plaques compared to men with prevalence of stable atherosclerotic plaques in coronary arteries. Blood levels of hsCRP, IL-6 and IL-8 correlated with characteristics of coronary artery atherosclerotic plaques instability. Correlation between hsCRP blood level and hsCRP concentration in coronary artery intima/media material was also revealed. PMID:22839584

  14. Effect of QIMT and QAS in Evaluating Common Carotid Artery Function of Obese People at High Altitudes and Relative Analysis of Risk Factors of Coronary Heart Disease%超声射频信号血管内中膜分析技术在高海拔地区肥胖人群颈部血管功能评价及冠心病风险相关性分析中的应用

    Institute of Scientific and Technical Information of China (English)

    赵夏夏; 王译晗; 苗英; 宁方艳; 王海筠; 吉新雁; 李亚妮

    2012-01-01

    目的 探讨超声射频信号血管内中膜分析技术(quality intima-media thickness,QIMT)在高海拔地区肥胖人群颈部血管功能评价中的作用及其在冠心病风险相关性分析中的价值.方法 选择高海拔地区肥胖者275例(肥胖组)及健康体检者200例(正常组),比较两组体重指数及胆固醇水平,采用超声射频信号QIMT及动脉僵硬度分析技术(quality arterial stiffness,QAS)检测两组颈总动脉内膜中层厚度(intima-media thickness,IMT)、扩张性系数、顺应性系数、血管弹性系数、血管硬度参数,并对资料完整的患者进行10年内冠心病风险综合评估.结果 两组男性年龄、体重指数、颈总动脉IMT比较差异有统计学意义(P<0.01),总胆固醇、高密度脂蛋白胆固醇( HDL-C)比较差异无统计学意义(P>0.05);两组女性年龄、体重指数、总胆固醇、HDL-C、IMT比较差异均有统计学意义(P<0.05).肥胖组男性与正常组男性比较,冠心病风险总值、综合评估发病率、相关性风险增高,差异有统计学意义(P<0.05);肥胖组女性与正常组女性比较,冠心病风险总值、综合评估发病率、平均发病率、正常范围的下限、相关性风险均增高,差异有统计学意义(P<0.01).结论 超声射频信号QIMT对肥胖人群IMT及冠心病相对危险性进行评估,具有无创、精确度高、重复性好、操作简便等诸多优点,可作为早期动脉硬化可靠、简便的检查技术.%Objective To study the effect of Quality Intima-Media Thickness (QIMT)and Quality Arterial Stiffness (QAS)in evaluating common carotid artery function of obese people at high altitudes and relative analysis of risk factors of coronary heart disease (CHD). Methods 275 obese people at high altitudes were selected as obese group, and 200 people who underwent healthy examination were selected as normal group. Body weight index and cholesterol of the two groups were detected, QIMT and QAS

  15. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence.

    Science.gov (United States)

    Luz, P L da; Coimbra, S; Favarato, D; Albuquerque, C; Mochiduky, R I; Rochitte, C E; Hojaij, E; Gonsalves, C R L; Laurindo, F R

    2014-08-01

    Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9 ± 7.3 years (means ± SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥ 50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4 ± 362.2 vs 122.0 ± 370.3; Phistory of diabetes and exercised more. RW drinkers consumed 2127.9 ± 387.7 kcal/day while abstainers consumed 1836.0 ± 305.0 (Pwine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.

  16. Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis.

    Science.gov (United States)

    Serdaroğlu Beyazal, Münevver; Erdoğan, Turan; Türkyılmaz, Aysegül Kücükali; Devrimsel, Gül; Cüre, Medine Cumhur; Beyazal, Mehmet; Sahin, Ismail

    2016-09-01

    Patients with ankylosing spondylitis (AS) reportedly have a higher mortality and morbidity risk. Osteoprotegerin (OPG) was recently defined as an important cardiovascular (CV) marker in the general population. We aimed to assess the relationship of serum OPG levels with arterial stiffness, carotid intima media thickness (CIMT), and clinical and laboratory data in AS patients. We examined 60 AS patients without CV disease or risk factors and 50 healthy controls. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS), whereas functional capacity was evaluated using the Bath Ankylosing Spondylitis Functional Index (BASFI). Serum OPG levels were measured with the enzyme-linked immunosorbent assay. Carotid-femoral pulse wave velocity (PWV) was used as an indicator of arterial stiffness, whereas CIMT (examined via carotid ultrasonography) was used to evaluate preclinical atherosclerosis. The mean serum OPG level, PWV, and CIMT were significantly higher in AS patients than in controls (106.7 ± 50.9 vs. 58.1 ± 12.7 pg/mL; 7.4 ± 1.8 vs. 6.2 ± 1.2 m/s; 0.72 ± 0.13 vs. 0.57 ± 0.07 mm, respectively; P < 0.001 for all). In AS patients, the serum OPG levels were not significantly correlated with PWV and CIMT but were significantly correlated with erthrocyte sedimentation rate, BASFI, and ASDAS. AS patients without CV disease or risk exhibited high OPG levels and increased PWV and CIMT values. Although OPG levels were not significantly correlated with PWV or CIMT, future long-term follow-up studies will help define the predictive value of OPG in these patients.

  17. Association between poor glycemic control, impaired sleep quality, and increased arterial thickening in type 2 diabetic patients.

    Directory of Open Access Journals (Sweden)

    Koichiro Yoda

    Full Text Available Poor sleep quality is an independent predictor of cardiovascular events. However, little is known about the association between glycemic control and objective sleep architecture and its influence on arteriosclerosis in patients with type-2 diabetes mellitus (DM. The present study examined the association of objective sleep architecture with both glycemic control and arteriosclerosis in type-2 DM patients.Cross-sectional study in vascular laboratory.The subjects were 63 type-2 DM inpatients (M/F, 32/31; age, 57.5±13.1 without taking any sleeping promoting drug and chronic kidney disease. We examined objective sleep architecture by single-channel electroencephalography and arteriosclerosis by carotid-artery intima-media thickness (CA-IMT.HbA1c was associated significantly in a negative manner with REM sleep latency (interval between sleep-onset and the first REM period (β=-0.280, p=0.033, but not with other measurements of sleep quality. REM sleep latency associated significantly in a positive manner with log delta power (the marker of deep sleep during that period (β=0.544, p=0.001. In the model including variables univariately correlated with CA-IMT (REM sleep latency, age, DM duration, systolic blood pressure, and HbA1c as independent variables, REM sleep latency (β=-0.232, p=0.038, but not HbA1c were significantly associated with CA-IMT. When log delta power was included in place of REM sleep latency, log delta power (β=-0.257, p=0.023 emerged as a significant factor associated with CA-IMT.In type-2 DM patients, poor glycemic control was independently associated with poor quality of sleep as represented by decrease of REM sleep latency which might be responsible for increased CA-IMT, a relevant marker for arterial wall thickening.

  18. Epicardial adipose tissue and pericoronary fat thickness measured with 64-multidetector computed tomography: potential predictors of the severity of coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Demircelik, Muhammed Bora; Gurel, Ozgul Malcok; Selcoki, Yusuf; Atar, Inci Asli; Eryonucu, Beyhan, E-mail: drdemircelik@yahoo.com [Turgut Ozal Univercity, Department of Cardiology, Ankara (Turkey); Bozkurt, Alper; Akin, Kayihan [Turgut Ozal Univercity, Department of Radiology, Ankara (Turkey); Yilmaz, Omer Caglar [Ankara Occupational Diseases Hospital, Department of Cardiology, Ankara (Turkey)

    2014-06-15

    Objective: the aim of the present study was to investigate the relationship between pericoronary fat and the severity and extent of atherosclerosis, quantified using 64-multidetector computed tomography, in patients with suspected coronary artery disease. Methods: the study population consisted of 131 patients who were clinically referred for noninvasive multislice computed tomography coronary angiography for the evaluation of coronary artery disease. Patients were classified as follows: no atherosclerosis, Group 1; nonobstructive atherosclerosis (luminal narrowing < 50% in diameter), Group 2; and obstructive atherosclerosis (luminal narrowing ≧ 50%) in a single vessel or obstructive atherosclerosis in the left main coronary artery and/or multiple vessels, Group 3. Epicardial adipose tissue was defined as the adipose tissue between the surface of the heart and the visceral layer of the pericardium (visceral epicardium). Epicardial adipose tissue thickness (mm) was determined in the right ventricular anterior free wall. The mean thickness of the pericoronary fat surrounding the three coronary arteries was used for the analyses. Results: the average thickness over all three regions was 13.2 ± 2.1 mm. The pericoronary fat thickness was significantly increased in Group 3 compared with Groups 2 and 1. The epicardial adipose tissue thickness was significantly increased in Group 3 compared with Groups 2 and 1. A receiver operating characteristic curve for obstructive coronary artery disease was assessed to verify the optimum cut-off point for pericoronary fat thickness, which was 13.8 mm. A receiver operating characteristic curve for obstructive coronary artery disease was also assessed to verify the optimum cut-off point for epicardial adipose tissue, which was 6.8 cm. Conclusion: we showed that the epicardial adipose tissue and pericoronary fat thickness scores were higher in patients with obstructive coronary artery diseases. (author)

  19. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Yoo Hye

    2011-11-01

    Full Text Available Abstract Background Adipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited. Methods We enrolled 60 people with type 2 diabetes, with or without carotid plaque, and 30 participants with normal glucose tolerance. We measured serum omentin-1, high-sensitivity C-reactive protein (hsCRP levels, and the homeostasis model assessment of insulin resistance (HOMA-IR, as well as other cardiovascular risk factors. Vascular health was assessed by brachial ankle pulse wave velocity (baPWV and carotid intima-media thickness (IMT. Results Serum omentin-1 levels were significantly decreased in type 2 diabetes patients compared to normal glucose controls and was further reduced in type 2 diabetes patients with carotid plaque compared to those without carotid plaque. Multiple stepwise regression analysis showed that age, systolic blood pressure, history of use of statins, angiotensin receptor blockers or angiotensin-converting enzyme inhibitors, and serum omentin-1 level were independent factors determining baPWV in people with type 2 diabetes (r2 = 0.637. Furthermore, in multivariate logistic regression analysis, circulating omentin-1 level was an independent decisive factor for the presence of carotid plaque in type 2 diabetes patients, even after adjusting for age, gender, body mass index, systolic blood pressure, fasting blood glucose, low density lipoprotein cholesterol, and history of smoking and medication (odds ratio, 0.621; 95% confidence interval, 0.420-0.919; P = 0.017. Conclusions Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.

  20. Portal venous arterialization resulting in increased portal inflow and portal vein wall thickness in rats

    Institute of Scientific and Technical Information of China (English)

    Wen-Gang Li; Yong-Liang Chen; Jing-Xi Chen; Lei Qu; Bin-Dang Xue; Zhi-Hai Peng; Zhi-Qiang Huang

    2008-01-01

    AIM:To explore the influence of portal vein hemodynamic changes after portal venous arterialization(PVA) on peribiliary vascular plexus (PVP)morphological structure and hepatic pathology,and to establish a theoretical basis for the clinical application of PVA.METHODS:Sprague-Dawley rats were randomly divided into control and PVA groups.After PVA,hemodynamic changes of the portal vein and morphological structure of hepatohilar PVP were observed using Doppler ultrasound,liver function tests,ink perfusion transparency management and three-dimensional reconstruction of computer microvisualization,and pathological examination was performed on tissue from the bile duct wall and the liver.RESULTS:After PVA,the cross-sectional area and blood flow of the portal vein were increased,and the increase became more significant over time,in a certain range.If the measure to limit the flow in PVA was not adopted,the high blood flow would lead to dilatation of intrahepatic portal vein and its branches,increase in collagen and fiber degeneration in tunica intima.Except glutamic pyruvic transaminase (GPT),other liver function tests were normal.CONCLUSION:Blood with a certain flow and oxygen content is important for filling the PVP and meeting the oxygen requirement of the bile duct wall.After PVA,It is the anatomic basis to maintain normal morphology of hepatohilar bile duct wall that the blood with high oxygen content and high flow in arterialized portal vein may fill PVP by collateral vessel reflux.A adequate measure to limit blood flow is necessary in PVA.

  1. Resistência insulínica pode prejudicar a redução da espessura mediointimal em adolescentes obesos Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents

    OpenAIRE

    Priscila de Lima Sanches; Marco Túlio de Mello; Francisco Antonio Helfestein Fonseca; Natália Elias; Aline de Piano; June Carnier; Lian Tock; Lila Missae Oyama; Sergio Tufik; Ana Dâmaso

    2012-01-01

    FUNDAMENTO: O processo aterosclerótico no nível endotelial começa em idade precoce e parece estar associado com a obesidade e suas comorbidades como a resistência insulínica. OBJETIVO: O objetivo deste estudo foi verificar a influência da resistência insulínica em marcadores inflamatórios e subclínicos de aterosclerose em adolescentes obesos. MÉTODOS: Sessenta e seis adolescentes obesos pós-púberes foram divididos em dois grupos de acordo com o índice de resistência insulínica estimado pelo M...

  2. Effects of atorvastatin and simvastatin on low-density lipoprotein subfraction profile, low-density lipoprotein oxidizability, and antibodies to oxidized low-density lipoprotein in relation to carotid intima media thickness in familial hypercholesterolemia.

    NARCIS (Netherlands)

    Tits, L.J.H. van; Smilde, T.J.; Wissen, S. van; Graaf, J. de; Kastelein, J.J.P.; Stalenhoef, A.F.H.

    2004-01-01

    BACKGROUND: Little is known about the effects of statins on the quality of circulating low-density lipoprotein (LDL) in relation to atherosclerosis progression. METHODS: In a double-blind, randomized trial of 325 patients with familial hypercholesterolemia (FH), we assessed the effects of high-dose

  3. The Association of Soluble OX40 Ligand Level and Carotid Intima-Media Thickness in Coronary Heart Disease%可溶性OX40配体与颈动脉内膜中膜厚度的关系

    Institute of Scientific and Technical Information of China (English)

    彭道泉; 黄珊; 赵水平

    2009-01-01

    目的 观察冠心病稳定型心绞痛患者及高危因素患者血浆中可溶性OX40配体水平,同时测定颈动脉内膜中膜厚度,分析两者的相关性,进一步探讨可溶性OX40配体与冠心病的关系.方法 采用酶联免疫吸附法测定35例稳定型心绞痛患者、30例高危因素者及20例正常对照者血浆中可溶性OX40配体浓度,同时利用彩色超声仪测量颈动脉内膜中膜厚度.结果 稳定型心绞痛患者血浆可溶性OX40配体水平(24.95±15.60 ng/L)高于正常对照者(16.44±11.31 ng/L;P<0.05);稳定型心绞痛患者和高危因素者的颈动脉内膜中膜厚度高于正常对照者(P<0.05),且与血浆可溶性OX40配体显著正相关(r=0.376,P=0.001).多因素回归分析显示,在控制年龄、血脂及血压影响后,可溶性OX40配体水平对内膜中膜厚度有独立的贡献(P=0.019).结论 冠心病患者可溶性OX40配体水平显著增高,且与颈动脉内膜中膜厚度独立相关,提示可溶性OX40配体可作为判断冠心痛及动脉粥样硬化新的炎症指标.

  4. 长期炭黑暴露与颈动脉内中膜厚度:标准化衰老研究%Long-term exposure to black carbon and carotid intima-media thickness: the normative aging study

    Institute of Scientific and Technical Information of China (English)

    Elissa H.Wilker; Murray A.Mittleman; Brent A.Coull; Alexandros Gryparis; Michiel L.Bots; Joel Schwartz; David Sparrow; 王晓宇; 汪源

    2014-01-01

    [背景]有证据表明,空气污染与动脉粥样硬化相关,且交通源颗粒物是此相关性极其重要的归因.[目的]研究居住在马塞诸塞州大波士顿地区的老年男性长期炭黑暴露与颈总动脉内中膜厚度(CIMT)之间的相关性.[方法]在标准化衰老研究参与者进行首次CIMT测量之前,评估他们住址处的一年平均炭黑暴露水平.使用混合效应模型评估炭黑水平估值与CIMT之间的相关性,计算重复的结果测定指标.在二次分析中,研究居住在主干道附近或住宅100m内的日均交通流量是否与CIMT相关.[结果]2004-2008年间,共有380名参与者(97%自述为白种人)接受了首次访问.每隔1.5年,分别有340名(89%)参与者接受了二次访问,260名(68%)参与者接受了三次访问.第一次检查时,参与者的年龄(均数±标准差)为(76±6.4)岁,CIMT(均数±标准差)为(0.99±0.18)mm.根据完全校正的模型,一年平均炭黑暴露每增加1个四分位数间距范围(0.26 μg/m3),CIMT增加1.1%(95%CI:0.1%~1.7%). [结论]在老年男性中,根据空间分辨暴露估值得出的年平均炭黑浓度与CIMT相关.本文的结果表明,长期空气污染暴露与动脉粥样硬化之间存在相关性.

  5. Carotid artery calcification at the initiation of hemodialysis is a risk factor for cardiovascular events in patients with end-stage renal disease: a cohort study

    Directory of Open Access Journals (Sweden)

    Ikeda Hirofumi

    2011-10-01

    Full Text Available Abstract Background Vascular calcification has been recognized as a risk factor for cardiovascular (CV events in patients with end-stage renal disease (ESRD. However, the association of carotid artery calcification (CAAC with CV events remains unknown. The aim of this study was to elucidate whether CAAC is associated with composite CV events in ESRD patients. Methods One-hundred thirty-three patients who had been started on hemodialysis between 2004 and 2008 were included in this retrospective cohort study. These patients received multi-detector computed tomography to assess CAAC at the initiation of hemodialysis. Composite CV events, including ischemic heart disease, heart failure, cerebrovascular diseases, and CV deaths after the initiation of hemodialysis, were examined in each patient. Results CAAC was found in 94 patients (71%. At the end of follow-up, composite CV events were seen in 47 patients: ischemic heart disease in 20, heart failure in 8, cerebrovascular disease in 12, and CV deaths in 7. The incidence of CAAC was 87% in patients with CV events, which was significantly higher than the rate (62% in those without. Kaplan-Meier analysis showed a significant increase in composite CV events in patients with CAAC compared with those without CAAC (p = 0.001, log-rank test. Univariate analysis using a Cox hazards model showed that age, smoking, common carotid artery intima-media thickness and CAAC were risk factors for composite CV events. In multivariate analysis, only CAAC was a significant risk factor for composite CV events (hazard ratio, 2.85; 95% confidence interval, 1.18-8.00; p = 0.02. Conclusions CAAC is an independent risk factor for CV events in ESRD patients. The assessment of CAAC at the initiation of hemodialysis is useful for predicting the prognosis.

  6. Predictors of Subclinical Cardiovascular Disease in Women with Polycystic Ovary Syndrome: Interrelationship of Dyslipidemia and Arterial Blood Pressure

    Directory of Open Access Journals (Sweden)

    Djuro Macut

    2015-01-01

    Full Text Available Background. Women with polycystic ovary syndrome (PCOS could develop subclinical atherosclerosis during life. Purpose. To analyze cardiovascular risk (CVR factors and their relation to clinical markers of cardiovascular disease (CVD in respect to their age. Material and Methods. One hundred women with PCOS (26.32±5.26 years, BMI: 24.98±6.38 kg/m2 were compared to 50 respective controls. In all subjects, total cholesterol (TC, HDL-C, LDL-C, triglycerides, TC/HDL-C and TG/HDL-C ratios, glucose, insulin and HOMA index, waist-to-hip ratio (WHR, systolic and diastolic blood pressure (SBP and DBP, resp., and carotid intima-media thickness (CIMT were analyzed in respect to their age and level of androgens. Results. PCOS over 30 years had higher WHR (P=0.008, SBP (P<0.001, DBP (P<0.001, TC (P=0.028, HDL-C (P=0.028, LDL-C (P=0.045, triglycerides (P<0.001, TC/HDL-C (P<0.001, and triglycerides/HDL-C (P<0.001 and had more prevalent hypertension and pronounced CIMT on common carotid arteries even after adjustment for BMI (P=0.005 and 0.036, resp.. TC/HDL-C and TG/HDL-C were higher in PCOS with the highest quintile of FAI in comparison to those with lower FAI (P=0.045 and 0.034, resp.. Conclusions. PCOS women older than 30 years irrespective of BMI have the potential for early atherosclerosis mirrored through the elevated lipids/lipid ratios and through changes in blood pressure.

  7. Risk Factors of Flow-empty Area in Carotid Artery in Doppler Power Imaging%颈动脉多普勒能量图中出现流空区的危险因素

    Institute of Scientific and Technical Information of China (English)

    于冬; 刘吉良; 田东旭

    2015-01-01

    Purpose To explore the reason which resulted in the flow-empty area in carotid artery, establishing a logistic regression model of carotid artery by power Doppler ultrasound, screening the risk factors of the occurrence of this phenomenon and analyzing their reasons. Materials and Methods Clinical data of 172 male subjects who had undergone power Doppler ultrasound were analyzed retrospectively, whether there was flow-empty area at the edge of carotid artery lumen during diastole was observed, brachial artery systolic pressure, diastolic pressure and pressure difference, carotid artery intima media thickness, and the existence of atherosclerotic plaques was measured, the age, body mass index (BMI), blood glucose, blood lipid, history of smoking and cerebrovascular accident situation was collected to establish the logistic model to analyze the risk factors resulted in flow-empty area. Results Among the 172 patients, intima media thickened in 89 cases, systolic blood pressure increased in 97 cases, diastolic blood pressure increased in 7 cases, the pulse pressure increased in 90 cases, with the age of 65 years or older in 92 cases, atherosclerotic plaque formation in 84 cases, long smoking history in 63 cases, cerebral vascular accident history in 11 cases, diabetes mellitus in 79 cases, hyperlipidemia in 101 cases, and abnormal BMI in 13 cases. Doppler energy imaging showed flow-empty area wave type in 98 cases, no flow-empty area wave type in 74 cases. 5 statistically significant variables for the occurrence of flow-empty area in carotid artery lumen during diastole were selected using logistic regression, which were carotid artery intima media thickness, BASP, the pressure difference of brachial artery, existence of atherosclerotic plaque, and the age of patients (OR=50.643, 47.248, 29.426, 32.667 and 20.514, P<0.05). Conclusion The risk factors resulted in "flow-empty area" in carotid artery are increased IMT, systolic BP and pressure difference, existence of

  8. Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries

    Science.gov (United States)

    Grainger, S. J.; Su, J. L.; Greiner, C. A.; Saybolt, M. D.; Wilensky, R. L.; Raichlen, J. S.; Madden, S. P.; Muller, J. E.

    2016-03-01

    The ability to determine plaque cap thickness during catheterization is thought to be of clinical importance for plaque vulnerability assessment. While methods to compositionally assess cap integrity are in development, a method utilizing currently available tools to measure cap thickness is highly desirable. NIRS-IVUS is a commercially available dual imaging method in current clinical use that may provide cap thickness information to the skilled reader; however, this is as yet unproven. Ten autopsy hearts (n=15 arterial segments) were scanned with the multimodality NIRS-IVUS catheter (TVC Imaging System, Infraredx, Inc.) to identify lipid core plaques (LCPs). Skilled readers made predictions of cap thickness over regions of chemogram LCP, using NIRS-IVUS. Artery segments were perfusion fixed and cut into 2 mm serial blocks. Thin sections stained with Movat's pentachrome were analyzed for cap thickness at LCP regions. Block level predictions were compared to histology, as classified by a blinded pathologist. Within 15 arterial segments, 117 chemogram blocks were found by NIRS to contain LCP. Utilizing NIRSIVUS, chemogram blocks were divided into 4 categories: thin capped fibroatheromas (TCFA), thick capped fibroatheromas (ThCFA), pathological intimal thickening (PIT)/lipid pool (no defined cap), and calcified/unable to determine cap thickness. Sensitivities/specificities for thin cap fibroatheromas, thick cap fibroatheromas, and PIT/lipid pools were 0.54/0.99, 0.68/0.88, and 0.80/0.97, respectively. The overall accuracy rate was 70.1% (including 22 blocks unable to predict, p = 0.075). In the absence of calcium, NIRS-IVUS imaging provided predictions of cap thickness over LCP with moderate accuracy. The ability of this multimodality imaging method to identify vulnerable coronary plaques requires further assessment in both larger autopsy studies, and clinical studies in patients undergoing NIRS-IVUS imaging.

  9. Aterosclerose carotídea avaliada pelo eco-Doppler: associação com fatores de risco e doenças arteriais sistêmicas Carotid atherosclerosis evaluated by Doppler ultrasound: association with risk factors and systemic arterial disease

    Directory of Open Access Journals (Sweden)

    Procopio de Freitas

    2008-12-01

    Full Text Available CONTEXTO: A aterosclerose carotídea apresenta alta prevalência populacional e associação com vários fatores de risco, contribuindo para altos índices de morbidade e mortalidade. OBJETIVO: Pesquisar a freqüência e associação da aterosclerose de carótidas extracranianas com: idade, sexo, hipertensão arterial, doença coronária isquêmica, tabagismo, diabetes melito tipo 2, obesidade, doença arterial oclusiva periférica, acidente vascular cerebral, oclusão carotídea, espessamento médio-intimal e acotovelamento. MÉTODOS: Foram avaliadas as artérias carótidas extracranianas, bilateralmente, de 367 indivíduos (132 homens e 235 mulheres com idade média de 63 anos (35 a 91 anos por anamnese, semiologia clínica e ultra-sonografia. A possibilidade da associação entre aterosclerose carotídea representada por placas ateromatosas inespecíficas com estenose > 10%, ateromatose discreta e difusa com estenose 64 anos, acidente vascular cerebral, obesidade e tabagismo. Considerando-se somente estenoses carotídeas > 60%, houve associação com idade > 64 anos, oclusão carotídea e doença coronária. O espessamento médio-intimal apresentou associação com idade > 64 anos, acotovelamento, oclusão carotídea, hipertensão arterial e índice tornozelo-braquial BACKGROUND: A high prevalence of carotid atherosclerosis in the population and its frequent association with several risk factors contribute to high morbidity and mortality rates. OBJECTIVE: To investigate frequency and association of extracranial carotid atherosclerosis with age, sex, hypertension, ischemic coronary disease, smoking, type 2 diabetes mellitus, obesity, peripheral arterial disease, stroke, carotid occlusion, intima-media thickness and kinking. METHODS: The carotid and bilateral extracranial arteries of 367 individuals (132 males and 235 females, with a mean of 63 years of age (35-91 years were evaluated via anamnesis, clinical semiology and ultrasonography. The

  10. CARDIAC TRANSPLANT REJECTION AND NON-INVASIVE COMON CAROTID ARTERY WALL FUNCTIONAL INDICES

    Directory of Open Access Journals (Sweden)

    A. O. Shevchenko

    2015-01-01

    Full Text Available Allograft rejection would entail an increase in certain blood biomarkers and active substances derived from activated inflammatory cells which could influence entire vascular endothelial function and deteriorate arterial wall stiffness. We propose that carotid wall functional indices measured with non-invasive ultrasound could we valuable markers of the subclinical cardiac allograft rejection. Aim. Our goal was to analyze the clinical utility of functional common carotid wall (CCW variables measured with high-resolution Doppler ultrasound as a non-invasive screening tool for allograft rejection in cardiac transplant patients (pts. Methods. One hundred and seventy one pts included 93 cardiac recipients, 30 dilated cardiomyopathy waiting list pts, and 48 stable coronary artery disease (SCAD pts without decompensated heart failure were included. Along with resistive index (Ri, pulsative index (Pi, and CCW intima-media thickness (IMT, CCW rigidity index (iRIG was estimated using empirical equation. Non-invasive evaluation was performed in cardiac transplant recipients prior the endomyo- cardial biopsy. Results. Neither of Ri, Pi, or CCW IMT were different in studied subgroups. iRIG was signifi- cantly lower in SCAD pts when compared to the dilated cardiomyopathy subgroup. The later had similar values with cardiac transplant recipients without rejection. Antibody-mediated and cellular rejection were found in 22 (23.7% and 17 (18.3% cardiac recipients, respectively. Mean iRIG in pts without rejection was significantly lower in comparison to antibody-mediated rejection and cell-mediated (5514.7 ± 2404.0 vs 11856.1 ± 6643.5 and 16071.9 ± 10029.1 cm/sec2, respectively, p = 0.001. Area under ROC for iRIG was 0.90 ± 0.03 units2. Analysis showed that iRIG values above estimated treshold 7172 cm/sec2 suggested relative risk of any type of rejection 17.7 (95%CI = 6.3–49.9 sensitivity 80.5%, specificity – 81.1%, negative predictive value – 84

  11. Assessment of influence of traditional cardiovascular risk factors and inflammation on arterial wall structural characteristics in psoriatic arthritis

    Directory of Open Access Journals (Sweden)

    T V Korotaeva

    2009-01-01

    Full Text Available Assessment of influence of traditional cardiovascular risk factors and inflammation on arterial wall structural characteristics in psoriatic arthritis. Objective. To assess possibility of traditional cardiovascular risk (CVR factors application as markers of subclinical atherosclerosis in pts with psoriatic arthritis (PA. Material and methods. 130 pts with PA (51 male and 79 female without clinical signs of coronary heart disease (CHD and stroke. were included. Mean age was 43 years (39-48 years, mean PA duration – 7 years (2 months-42 years, mean psoriasis duration – 15 years (5,5 – 26 years. PA activity was assessed with DAS4. Age, total cholesterol (TC, high density lipoprotein (HDLP, low density lipoprotein (LDLP, C-reactive protein (CRP, fibrinogen, systolic blood pressure, body mass index (BMI, atherogenity coefficient (AC, relative risk of CHD development, presence of diabetes and smoking were evaluated. Mean and maximal intima-media complex thickness (IMCT of common carotid arteries was examined with duplex scanning. Results. TC, LDLP and AC elevation was revealed in all and BMI elevation – in one third of pts. In 55% of pts CVR was mean and higher, in 23,5% CVR was absent and in 21,5% CVR was below mean. CVR significantly correlated with mean and maximal carotid arteries IMCT (R=0,48, p<0,00001 and R=0,41, p<0,00001 and fibrinogen (R=0,22, p<0,011. In women CVR correlated with fibrinogen (R=0,27, p<0,16, BMI (R=0,35, p<0,16, mean and maximal carotid arteries IMCT (R=0,50, p<0,00001 and R=0,38, p<0,0005 respectively and psoriasis duration (R=0,30, p<0,006. In men CVR did not correlated with fibrinogen. CVR did not correlated with DAS4 and CRP. Conclusion. CVR in PA is not connected with traditional markers of inflammation andindex of clinical disease activity.

  12. Carotid and popliteal artery intima–media thickness in patients with poor oral hygiene and the association with acute-phase reactants

    OpenAIRE

    Uyar, Ihsan Sami; Besir Akpinar, Mehmet; Sahin, Veysel; Abacilar, Feyzi; Yurtman, Volkan; Fevzi Okur, Faik; Filiz Yasa, Elif

    2013-01-01

    Purpose The aim of this study was to evaluate whether poor oral hygiene is associated with carotid and popliteal arterial intima–media thickness, which is one of the predictors of future progression of sub-clinical atherosclerosis, and high-sensitivity C-reactive protein (hsCRP) and fibrinogen levels. Methods A specialised dentist checked the patients and selected 550 patients during periodontal examinations, according to their oral hygiene. The patients had no history of atherosclerotic dise...

  13. Relation between plaque type, plaque thickness, blood shear stress, and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound

    OpenAIRE

    Balocco, Simone; Gatta, Carlo; Alberti, Marina; Carrillo, Xavier; Rigla, Juan; Radeva, Petia

    2012-01-01

    Purpose: Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries. Methods: First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound(IVUS) and Angiograph...

  14. Time course of arterial remodelling in diameter and wall thickness above and below the lesion after a spinal cord injury

    NARCIS (Netherlands)

    Thijssen, D.H.J.; Groot, P.C. de; Bogerd, A. van den; Veltmeijer, M.; Cable, N.T.; Green, D.J.; Hopman, M.T.E.

    2012-01-01

    Physical inactivity in response to a spinal cord injury (SCI) represents a potent stimulus for conduit artery remodelling. Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by syste

  15. The impact of exercise training on conduit artery wall thickness and remodeling in chronic heart failure patients

    NARCIS (Netherlands)

    Maiorana, A.J.; Naylor, L.H.; Exterkate, A.; Swart, A.; Thijssen, D.H.J.; Lam, K.; O'Driscoll, G.; Green, D.J.

    2011-01-01

    Exercise training is an important adjunct to medical therapy in chronic heart failure, but the extent to which exercise impacts on conduit artery remodeling is unknown. The aim of this study was to evaluate the impact of aerobic and resistance exercise training modalities on arterial remodeling in p

  16. To assess the intimal thickness, flow velocities, and luminal diameter of carotid arteries using high-resolution B-mode ultrasound doppler imaging

    Science.gov (United States)

    Vemuru, Madhuri; Jabbar, Afzal; Chandra, Suman

    2004-04-01

    Carotid imaging is a Gold Standard test that provides useful information about the structure and functions of carotid arteries. Spectral imaging helps to evaluate the vessel and hemodynamic changes. High resolution B-mode imaging has emerged as one of the methods of choice for determining the anatomic extent of atherosclerosis and its progression and for assessing cardiovascular risks. The measurements made with Doppler correlate well with pathologic measurements. Recent prospective studies have clearly demonstrated that these measurements of carotid intimal thickness are potent predictors of Myocardial Infarction and Stroke. This method appears very attractive as it is non-invasive, extremely safe, well accepted by the patient and relatively inexpensive. It can be performed serially and has the advantage of visualizing the arterial wall in contrast to angiographic techniques which provide only an outline of the arterial lumen. Recently, there has been an interest in the clinical use of this technique in making difficult clinical decisions like deciding on preventive therapies. 30 subjects aged 21-60 years and 30 subjects aged 61-85 years of both sexes are selected after doing a baseline study to exclude Hypertension, Diabetes, Obesity and Hyperlipidemia. The carotid arteries were examined for intimal thickening, blood flow velocities and luminal diameter. With aging there is a narrowing of the carotid vessels and significant increase in intimal thickening with a consequent increase in the blood flow velocities. Inter-observer, intra-observer and instrument variations are seen and there is no significant change in the values when the distal flow pattern is considered for measurements. Aging produces major cardiovascular changes including decreased elasticity and compliance of great arteries leading to structural and functional alterations in heart and vessels. With aging there is increased intimal thickness and increased pulse wave velocity which is clearly

  17. Cardiovascular risk factor profiles for peripheral artery disease and carotid atherosclerosis among Chinese older people: a population-based study.

    Directory of Open Access Journals (Sweden)

    Yajun Liang

    Full Text Available OBJECTIVES: Epidemiological data concerning atherosclerotic disease among older people in rural China are sparse. We seek to determine prevalence and cardiovascular risk factor profiles for peripheral artery disease (PAD and carotid atherosclerosis (CAS among Chinese older people living in a rural community. METHODS: This cross-sectional study included 1499 participants (age ≥60 years, 59.0% women of the Confucius Hometown Aging Project in Shandong, China. From June 2010-July 2011, data were collected through interviews, clinical examinations, and laboratory tests. PAD was defined as an ankle-brachial index ≤0.9. Carotid intima-media thickness (cIMT and carotid artery stenosis were assessed by ultrasonography. We defined moderate stenosis as carotid stenosis ≥50%, and severe stenosis as carotid stenosis ≥70%. cIMT≥1.81 mm was considered as an increased cIMT (a measure of CAS. Data were analyzed with multiple logistic models. RESULTS: The prevalence was 5.7% for PAD, 8.9% for moderate stenosis, 1.8% for severe stenosis, and 11.2% for increased cIMT. After controlling for multiple potential confounders, diabetes, an increased low-density lipoprotein cholesterol (LDL-C/high-density lipoprotein cholesterol (HDL-C ratio, and hypertension were significantly or marginally associated with PAD. Ever smoking, hypertension, and an increased LDL-C/HDL-C ratio were significantly associated with an increased likelihood of increased cIMT. An increasing number of those cardiovascular risk factors were significantly associated with an increasing odds ratio of PAD and increased cIMT, respectively (p for linear trend <0.001. CONCLUSION: Among Chinese older people living in a rural community, PAD, carotid artery stenosis, and an increased cIMT are relatively uncommon. Cardiovascular risk factor profiles for PAD and CAS are slightly different, with hypertension and an increased LDL-C/HDL-C ratio being associated with an increased likelihood of both PAD and

  18. Structural alterations of the coronary arterial wall are associated with myocardial flow heterogeneity in type 2 diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Schindler, Thomas H. [California Univ., Los Angeles, CA (United States). Dept. of Moelecular and Medical Pharmacology, Radiological Science]|[University Hospital of Geneva, Department of Internal Medicine, Cardiovascular Center, Nuclear Cardiology, Geneva (Switzerland); Facta, Alvaro D.; Prior, John O.; Cadenas, Jerson; Zhang, Xiao-Li; Sayre, James; Goldin, Jonathan; Schelbert, Heinrich R. [California Univ., Los Angeles, CA (United States). Dept. of Moelecular and Medical Pharmacology, Radiological Science; Li, Yanjie [University of Southern California, Atherosclerosis Research Unit, Keck School of Medicine, Los Angeles, CA (United States)

    2009-02-15

    To determine the relationship between carotid intima-media thickness (IMT), coronary artery calcification (CAC), and myocardial blood flow (MBF) at rest and during vasomotor stress in type 2 diabetes mellitus (DM). In 68 individuals, carotid IMT was measured using high-resolution vascular ultrasound, while the presence of CAC was determined with electron beam tomography (EBT). Global and regional MBF was determined in milliliters per gram per minute with {sup 13}N-ammonia and positron emission tomography (PET) at rest, during cold pressor testing (CPT), and during adenosine (ADO) stimulation. There was neither a relationship between carotid IMT and CAC (r = 0.10, p = 0.32) nor between carotid IMT and coronary circulatory function in response to CPT and during ADO (r = -0.18, p = 0.25 and r = 0.10, p = 0.54, respectively). In 33 individuals, EBT detected CAC with a mean Agatston-derived calcium score of 44 {+-} 18. There was a significant difference in regional MBFs between territories with and without CAC at rest and during ADO-stimulated hyperemia (0.69 {+-} 0.24 vs. 0.74 {+-} 0.23 and 1.82 {+-} 0.50 vs. 1.95 {+-} 0.51 ml/g/min; p {<=} 0.05, respectively) and also during CPT in DM but less pronounced (0.81 {+-} 0.24 vs. 0.83 {+-} 0.23 ml/g/min; p = ns). The increase in CAC was paralleled with a progressive regional decrease in resting as well as in CPT- and ADO-related MBFs (r = -0.36, p {<=} 0.014; r = -0.46, p {<=} 0.007; and r = -0.33, p {<=} 0.041, respectively). The absence of any correlation between carotid IMT and coronary circulatory function in type 2 DM suggests different features and stages of early atherosclerosis in the peripheral and coronary circulation. PET-measured MBF heterogeneity at rest and during vasomotor stress may reflect downstream fluid dynamic effects of coronary artery disease (CAD)-related early structural alterations of the arterial wall. (orig.)

  19. Giant Splenic Artery Pseudoaneurysm: A Case Report and Literature Review.

    Science.gov (United States)

    Yagmur, Yusuf; Akbulut, Sami; Gumus, Serdar; Demircan, Firat

    2015-07-01

    Splenic artery aneurysms (SAAs) are the third most frequent intra-abdominal aneurysm, following abdominal aorta and iliac artery aneurysms. SAAs are classified according to their involvement of arterial wall layers: true aneurysms involve all 3 layers (intima, media, and adventitia), and pseudoaneurysms involve only one or two. Herein we present a new case of giant pseudo SAA. A 65-year-old female patient with a pancreatic mass and iron deficiency was referred to our clinic for further investigation. Abdominal ultrasonography, contrast-enhanced CT and magnetic resonance imaging showed a lesion resembling a subcapsular hemangioma in the spleen, and aneurysmatic dilation of the splenic artery with a diameter of >5 cm. The large size of the aneurysm and the clinical findings were indications for surgical treatment. The patient underwent en bloc resection of the spleen, distal pancreas, and aneurysmatic segment of the splenic artery. The patient remains complication-free 2 months after the operation. Spontaneous rupture is the most important life-threatening complications of giant SAAs. Therefore, all symptomatic patients with SAA should be treated, as well as asymptomatic patients with lesions ≥2 cm, who are pregnant or fertile, have portal hypertension, or are candidates for liver transplantation. Despite advances in endovascular techniques, conventional abdominal surgery remains the gold standard for treatment. PMID:26595501

  20. Predictive role of carotid artery ultrasound parameters in maintenance hemodialysis patients with atherosclerotic cardiovascular disease%颈动脉超声参数在评价维持性血液透析患者动脉粥样硬化性心血管疾病中的应用

    Institute of Scientific and Technical Information of China (English)

    崔峥; 张新天; 顾俊毅; 王敏; 齐华林; 陈明

    2012-01-01

    目的 探讨维持性血液透析(MHD)患者颈动脉超声参数与Framingham危险评分(FRS)的关系及在预测动脉粥样硬化性心血管疾病(ASCVD)中的价值.方法 共入选129例MHD患者,采用FRS和共存疾病指数(ICED)评估MHD患者ASCVD及危险因素;颈动脉B超测定颈总动脉内-中膜厚度(CCA-IMT)、颈总动脉最大内-中膜厚度(CCA-IMTmax),计算颈总动脉内-中膜横切面积(CCA-IMarea),同时记录有无颈动脉斑块(CPs).结果 根据血管病变支数和严重程度评分分组,结果显示,随着血管支数增加和病变程度加重,CCA-IMT、CCA-IMarea、CCA-IMTmax、CPs和FRS逐渐增高(P<0.01).Logistic回归分析结果显示CPs、FRS是预测ASCVD发生的独立变量;CPs、FRS可独立预测冠状动脉性心脏病发生;CCA-IMT、CCA-IMarea可独立预测脑血管疾病发生;CPs、CCA-IMT、CCA-IMarea、FRS均可预测外周血管疾病发生.结论 CCA-IMT预测ASCVD的准确性优于CCA-IMarea、CCA-IMTmax.%To investigate the relation of carotid artery ultrasound parameters with Framingham risk score (FRS) and the predictive role of these parameters in maintenance hemodialysis (MHD) patients with atherosclerotic cardiovascular disease (ASCVD). Methods Totally 129 consecutive MHD patients were included. ASCVD and associated risk factors were assessed using Framingham risk score (FRS) and index of co-existing disease (ICED), Carotid artery intima-media thickness (IMT), cross-sectional calculated intima-media area (CCA-IMarea) were measured and carotid artery plaques (CPs) were observed with non-invasive high resolution B-mode ultrasonography. Results CCA-IMT, CCA-IMarea, CCA-IMTmax, CPs and FRS progressively increased according to number and severity of coexistent vascular diseases (P<0. 01). Results of the Logistic regression model showed that CPs and FRS were independently associated with ASCVD. CPs and FRS were independently associated with coronary heart disease. CCA-IMT and CCA-IMarea were

  1. Measurement of Change in Wall Thickness of Cylindrical Shell Due to Cyclic Remote Actuation for Assessment of Viscoelasticity of Arterial Wall

    Science.gov (United States)

    Hasegawa, Hideyuki; Kanai, Hiroshi; Koiwa, Yoshiro; Butler, James P.

    2003-05-01

    To characterize tissues in atherosclerotic plaques, we have developed a method, the phased tracking method, for measuring the strain (change in wall thickness) and elasticity of the arterial wall. However, some types of tissue, such as lipids and blood clots, cannot be discriminated from each other based only on elasticity because of the small difference in their elasticity. For more precise tissue characterization, we are attempting to measure the regional viscoelasticity. To determine viscoelastic properties, elastic moduli at multiple frequencies were obtained by generating the change in internal pressure due to remote cyclic actuation. From basic experiments using a silicone rubber tube, it was found that the change in internal pressure at the ultrasonic beam position (for measurement of the elastic modulus) can be generated by remotely applied actuation. Furthermore, from the resultant minute changes in wall thickness of less than 10 μm measured by the phased tracking method, elastic moduli were obtained at multiple actuation frequencies.

  2. Data density curves of B-mode ultrasound arterial wall thickness measurements in unaffected control and at-risk populations

    NARCIS (Netherlands)

    de Groot, E; Hovingh, GK; Zwinderman, AH; Wiegman, A; Smit, AJ; Kastelein, JJP

    2005-01-01

    Aim. Atherosclerosis is a slow disease process of arterial walls with onset decades prior to its clinical manifestations. Lifelong follow-up data may help to identify and understand the pathophysiology of this process. These longitudinal data are scarce. Using a standardized imaging and image analys

  3. Extremal states of energy of a double-layered thick-walled tube - application to residually stressed arteries.

    Science.gov (United States)

    Waffenschmidt, Tobias; Menzel, Andreas

    2014-01-01

    Various biological tissues are designed to optimally support external loads for complex geometries and mechanobiological structures. This results in complex microstructures of such materials. The design of, for instance, (healthy) arteries, which are in the focus of this work, is characterised by a residually stressed fibre-reinforced multi-layered composite with highly non-linear elastic response. The complex interaction of material properties with the geometry and residual stress effects enables the optimal support under different blood pressures, respectively blood flow, within the vessel. The fibres reinforcing the arterial wall, as well as residual stresses present in the vessel, strongly influence its overall behaviour and performance. Turn-over and remodelling processes of the collagenous fibres occurring in the respective layers - either resulting from natural growth phenomena or from artificially induced changes in loading condition such as stent deployment - support the optimisation of the multi-layered composite structure of arteries for the particular loading conditions present in the artery. Within this contribution, the overall energetic properties of an artery are discussed by means of the inflation, bending and extension of a double-layered cylindrical tube. Different states of residual stresses and different fibre orientations are considered so that, for instance, representative fibre angles that result in extremal states of the total potential energy can be identified. In view of turn-over and remodelling processes, these orientations are considered to constitute preferred directions of fibre alignment. In summary, the main goal of this work is to calculate optimal material, structural and loading parameters by concepts of energy-minimisation. Several numerical studies show that the obtained values - such as the fibre orientations, the residual axial stretch and the opening angle - are in good agreement with respective physiological parameters

  4. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    International Nuclear Information System (INIS)

    Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative

  5. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    Energy Technology Data Exchange (ETDEWEB)

    Luz, P.L. da; Coimbra, S.; Favarato, D.; Albuquerque, C. [Divisão de Cardiologia Clínica, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Mochiduky, R.I.; Rochitte, C.E. [Divisão de Radiologia, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Hojaij, E. [Serviço de Psicologia, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Gonsalves, C.R.L. [Serviço Nutricional, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Laurindo, F.R. [Laboratório de Biologia Vascular, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-07-04

    Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.

  6. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    Directory of Open Access Journals (Sweden)

    P.L. da Luz

    2014-08-01

    Full Text Available Observational studies suggest there are clinical benefits to moderate red wine (RW consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0, 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01. However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001. HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001, while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02. Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.

  7. Correlation analysis between the carotid artery ather osclerosis severity of patients with lacunar infarct and the level of serum uric acid, high-sensitivity C-reactive protein

    Directory of Open Access Journals (Sweden)

    WANG Shu

    2013-01-01

    Full Text Available Background Nowadays, clinical practice shows that the number of patients with cerebral infarction increases year by year in young and middle-aged adults with unclear causes. This paper aims to investigate the correlation between the level of serum uric acid (UA, high-sensitivity C-reactive protein (hsCRP and the degree of carotid atherosclerosis by detecting the level of UA, hsCRP and carotid intima-media thickness (IMT in young and middle-aged patients with lacunar infarct. Methods By using Holland Philips HT-11 color Doppler ultrasonic diagnostic apparatus with linear type probe and 7.50MHz frequency, IMT of end-diastolic distal and bifurcation of arteria carotis communis and proximal internal carotid artery were measured respectively on 186 patients with definitely diagnosed lacunar infarct. As a result, average values were taken as the IMT values. IMT < 1.00 mm was regarded as negative result and 1.00 mm ≤IMT < 1.20 mm was thickening of carotid artery intima. Carotid artery plaque formation was regarded with echo structure existing in the lumen or abnormal blood flow deficits into the lumen, or local IMT ≥1.20 mm at vertical and horizontal scan. At the same time, the levels of UA and hsCRP were detected, and correlation analysis was made between them and IMT. Results The values of UA, hsCRP and IMT in the case group were higher than that in the control group (P = 0.000. The differences among the case subgroups including IMT thickening group, plaque formation group and IMT normal group were statistically significant (P < 0.01, for all. There was linear correlation between the levels of UA, hsCRP and IMT ( r = 0.923, P = 0.000; r = 0.955, P = 0.008. Conclusion UA and hsCRP involve in the formation of atherosclerosis plaque and play an important role in the first-onset lacunar infarct patients without hypertension and other risk factors.

  8. 不同血糖水平患者血Hcy与颈动脉硬化关系探讨%THE RELATIONSHIP BETWEEN THE LEVEL OF PLASMA HOMOCYSTEINE AND CAROTID ARTERY ATHEROSCLEROSIS IN PATIENTS WITH DIFFERENT BLOOD GLUCOSE LEVELS

    Institute of Scientific and Technical Information of China (English)

    刘开渊; 胡淑兰

    2012-01-01

    目的 探讨不同血糖水平患者血浆同型半胱氨酸(homocysteine,Hcy)水平与颈动脉硬化关系.方法 通过对29例糖耐量正常者(normal glucose tolerance,NGT)、43例糖耐量异常(impaired glucose tolerance,IGT)者和37例糖尿病(diabetes mellitus,DM)患者的血浆Hcy、血脂、颈动脉内膜-中层厚度(intima-media thickness,IMT)、糖化血红蛋白(glycolated hemoglobin,HbA1c)和餐后2h血糖(2h postprandial plasma glucose,2hPG)进行检测,比较不同血糖水平患者血浆Hcy水平与颈动脉硬化的关系.结果 NGT组、IGT组和DM组患者间的血浆Hcy、颈动脉IMT、三酰甘油、2hPG比较差异有统计学意义(P<0.05).血浆Hcy水平与HbA1c、2hPG、颈总动脉IMT具有相关性(r=0.467、0.509、0.637,P均<0 05).结论 血浆Hcy水平升高是糖尿病患者合并颈动脉硬化的独立危险因素.%Objective To discuss the relationship between the level of plasma homocysteine and carotid artery atherosclerosis in patients with different blood glucose levels. Methods Plasma homocysteine, lipids, glycolated hemoglobin( HbA1c )and 2 hours postprandial plasma glucose( 2hPG ) were measured in 37 cases of diagnosed diabetes mellitus( DM ),43 cases of diagnosed impaired glucose tolerance( IGT ) and 29 cases with normal glucose tolerance( NGT ). The level of plasma homocysteine and carotid artery atherosclerosis in patients with different blood glucose levels were measured. Results There were significant differences in plasma homocysteine, internal - media thickness ( IMT ) and triglyceride and 2hPG among NGT group,IGT group and DM group ( P <0. 05 ),and Spearsman analysis showed that the patients' HbA1c,2hPG and IMT were closely related with plasma homocysteine( r = 0.467,0. 509, 0. 637, P < 0. 05 ). Conclusion The rising of plasma homocysteine level is an independent factor of diabetes mellitus combined carotid artery atherosclerosis.

  9. Adiponectin and cardiovascular remodeling in end-stage renal disease and co-morbid diabetes mellitus

    NARCIS (Netherlands)

    D. Karakitsos; E. de Groot; A.P. Patrianakos; F. Parthenakis; J. Boletis; A. Karabinis; J. Kyriazis; P. Vardas; E. Daphnis

    2006-01-01

    Objectives and Methods: Altered plasma high-sensitivity C-reactive protein (hs-CRP) and adiponectin (ADP) may contribute to increased vascular inflammation and accelerated atherosclerosis in patients with end-stage renal disease (ESRD) and co-morbid diabetes. Common carotid artery intima-media thick

  10. Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

    NARCIS (Netherlands)

    J. Willeit (Johann); S.G. Thompson (Simon G.); S. Agewall (Stefan); G. Bergstrom (Goran); H. Bickel (Horst); A. Catapano (Alberico); K.-L. Chien (Kuo-Liong); E. de Groot; J.P. Empana (Jean Philippe); T. Etgen (Thorleif); O.H. Franco (Oscar); B. Iglseder (Bernhard); S.H. Johnsen; M. Kavousi (Maryam); L. Lind (Lars); J. Liu (Jing); E.B. Mathiesen (Ellisiv); G.D. Norata (Giuseppe); M.H. Olsen (Michael H.); A. Papagianni (Aikaterini); H. Poppert (Holger); J.F. Price (Jackie F.); R.L. Sacco (Ralph); D. Yanez (David); D. Zhao (Dong); U. Schminke (Ulf); A. Bulbul (Alpaslan); J.F. Polak (Joseph F.); M. Sitzer (Matthias); A. Hofman (Albert); L. Grigore (Liliana); M. Dörr (Marcus); T.-C. Su (Ta-Chen); P. Ducimetiere (Pierre); W. Xie (Wuxiang); K. Ronkainen (Kimmo); S. Kiechl (Stefan); T. Rundek (Tatjana); C.M. Robertson (Christine M); B. Fagerberg (Bjorn); L. Bokemark (Lena); H. Steinmetz (helmuth); M.A. Ikram (Arfan); H. Völzke (Henry); H.-J. Lin (Hung-Ju); M. Plichart (Matthieu); T.-P. Tuomainen (Tomi-Pekka); M. Desvarieux (Moise); S. McLachlan (Stela); C. Schmidt (Caroline); J. Kauhanen (Jussi); J. Willeit (Johann); M.W. Lorenz (Matthias W.); D. Sander (Dirk)

    2016-01-01

    textabstractBackground Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (

  11. Carotid plaque burden as a measure of subclinical atherosclerosis

    DEFF Research Database (Denmark)

    Sillesen, Henrik; Muntendam, Pieter; Adourian, Aram;

    2012-01-01

    The purpose of this study was to compare carotid plaque burden, carotid intima-media thickness (cIMT), ankle-brachial index (ABI), and abdominal aortic diameter (AAD) to coronary artery calcium score (CACS) in people without known cardiovascular disease....

  12. Silent Ischemic Heart Disease and Pericardial Fat Volume in HIV-Infected Patients

    DEFF Research Database (Denmark)

    Kristoffersen, Ulrik S; Lebech, Anne-Mette; Wiinberg, Niels;

    2013-01-01

    to determine the prevalence of asymptomatic ischemic heart disease (IHD) in HIV patients by myocardial perfusion scintigraphy (MPS) and to determine the value of coronary artery calcium score (CACS), carotid intima-media thickness (cIMT) and pericardial fat volume as screening tools for detection...

  13. Despeckle filtering software toolbox for ultrasound imaging of the common carotid artery.

    Science.gov (United States)

    Loizou, Christos P; Theofanous, Charoula; Pantziaris, Marios; Kasparis, Takis

    2014-04-01

    Ultrasound imaging of the common carotid artery (CCA) is a non-invasive tool used in medicine to assess the severity of atherosclerosis and monitor its progression through time. It is also used in border detection and texture characterization of the atherosclerotic carotid plaque in the CCA, the identification and measurement of the intima-media thickness (IMT) and the lumen diameter that all are very important in the assessment of cardiovascular disease (CVD). Visual perception, however, is hindered by speckle, a multiplicative noise, that degrades the quality of ultrasound B-mode imaging. Noise reduction is therefore essential for improving the visual observation quality or as a pre-processing step for further automated analysis, such as image segmentation of the IMT and the atherosclerotic carotid plaque in ultrasound images. In order to facilitate this preprocessing step, we have developed in MATLAB(®) a unified toolbox that integrates image despeckle filtering (IDF), texture analysis and image quality evaluation techniques to automate the pre-processing and complement the disease evaluation in ultrasound CCA images. The proposed software, is based on a graphical user interface (GUI) and incorporates image normalization, 10 different despeckle filtering techniques (DsFlsmv, DsFwiener, DsFlsminsc, DsFkuwahara, DsFgf, DsFmedian, DsFhmedian, DsFad, DsFnldif, DsFsrad), image intensity normalization, 65 texture features, 15 quantitative image quality metrics and objective image quality evaluation. The software is publicly available in an executable form, which can be downloaded from http://www.cs.ucy.ac.cy/medinfo/. It was validated on 100 ultrasound images of the CCA, by comparing its results with quantitative visual analysis performed by a medical expert. It was observed that the despeckle filters DsFlsmv, and DsFhmedian improved image quality perception (based on the expert's assessment and the image texture and quality metrics). It is anticipated that the

  14. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

    DEFF Research Database (Denmark)

    Muscelli, Elza; Kozàkovà, Michaela; Flyvbjerg, Allan;

    2009-01-01

    secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. METHODS: In 74 menopausal women (mean age = 51 +/- 3 years, mean duration of menopause = 2.9 +/- 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid...... mathematical modeling. RESULTS: CCA diameter (5.55 +/- 0.46 vs. 5.21+/- 0.51 mm, P < 0.001), CCA IMT (608 +/- 78 vs. 576 +/- 74 microm, P < 0.01) and systolic blood pressure (BP) (117 +/- 12 vs. 113 +/- 11 mm Hg, P < 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid...

  15. Quantification of Adventitial Vasa Vasorum Vascularization in Double-injury Restenotic Arteries

    Institute of Scientific and Technical Information of China (English)

    Meng Ye; Bai-Gen Zhang; Lan Zhang; Hui Xie; Hao Zhang

    2015-01-01

    Background:Accumulating evidence indicates a potential role of adventitial vasa vasorum (VV) dysfunction in the pathophysiology of restenosis.However,characterization ofVV vascularization in restenotic arteries with primary lesions is still missing.In this study,we quantitatively evaluated the response of adventitial VV to vascular injury resulting from balloon angioplasty in diseased arteries.Methods:Primary atherosclerotic-like lesions were induced by the placement of an absorbable thread surrounding the carotid artery of New Zealand rabbits.Four weeks following double-injury induced that was induced by secondary balloon dilation,three-dimensional patterns of adventitial VV were reconstructed;the number,density,and endothelial surface of VV were quantified using micro-computed tomography.Histology and immunohistochemistry were performed in order to examine the development of intimal hyperplasia.Results:Results from our study suggest that double injured arteries have a greater number of VV,increased luminal surface,and an elevation in the intima/media ratio (I/M),along with an accumulation ofmacrophages and smooth muscle cells in the intima,as compared to sham or single injury arteries.I/M and the number of VV were positively correlated (R2 =0.82,P < 0.001).Conclusions:Extensive adventitial VV neovascularization occurs in injured arteries after balloon angioplasty,which is associated with intimal hyperplasia.Quantitative assessment of adventitial VV response may provide insight into the basic biological process of postangioplasty restenosis.

  16. The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction

    Directory of Open Access Journals (Sweden)

    Shu XU

    2015-11-01

    Full Text Available Objective To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction.  Methods Ninety-two patients with atherosclerotic cerebral infarction were randomly divided into two groups: observation group (treated by atorvastatin calcium with the dosage of 20 mg/d, N = 46 and control group (treated by diet without lipid-rich food, N=46. Besides, other drugs given to the patients in two groups were the same. The blood lipid levels and the changes of carotid artery plaques in two groups were analyzed and compared before treatment and 3 months after treatment. Results After treatment, the concentrations of total cholesterol [TC, (4.23 ± 0.92 mmol/L vs (5.24 ± 0.68 mmol/L], triglyceride [TG, (2.46 ± 0.28 mmol/L vs (3.33 ± 0.47 mmol/L], low-density lipoprotein cholesterol [LDL-C, (2.52 ± 0.38 mmol/L vs (4.78 ± 0.86 mmol/L] in the patients of observation group were all decreased and significantly lower than those in the control group (P = 0.000, for all, and the concentration of high-density lipoprotein cholesterol [HDL-C, (1.13 ± 0.41 mmol/L vs (0.85 ± 0.32 mmol/L] in the patients of observation group was increased and significantly than that in the control group (P = 0.003. The carotid artery plaque size [(20.25 ± 0.32 mm2 vs (24.42 ± 10.33 mm2] and thickness [(0.59 ± 0.13 mm vs (1.93 ± 0.23 mm] of carotid artery plaques and intima?media thickness [IMT, (1.32 ± 0.67 mm vs (1.63 ± 0.56 mm] of common carotid artery (CCA in the patients of observation group were all significantly lower than those in patients in the control group (P = 0.000, 0.000, 0.010, respectively. Comparing serum alanine aminotransferase (ALT, aspartate aminotransferase (AST, creatine kinase (CK and creatinine (Cr levels after treatment with before treatment, there was no significant difference between 2 groups (P > 0.05, for all.  Conclusions

  17. 胫前动脉血管内皮功能及血流动力学参数评价2型糖尿病下肢动脉病变%Clinical Evaluation of Peripherial Arterial Diseases with Anterior Tibial Arterial Endothelial Function and Hemodynamic Parameters in Type 2 Diabetic Patients

    Institute of Scientific and Technical Information of China (English)

    马婷; 姚兰辉; 崔凤荣; 康东; 成静

    2012-01-01

    目的:探讨胫前动脉血管内皮舒张功能及血流动力学参数与2型糖尿病下肢疾病的相关性,为2型糖尿病下肢动脉病变的超声诊断提供更多的理论依据.方法:本研究设计经伦理审查委员会批准,所有研究对象在检查前均已签署知情同意书.将159例2型糖尿病患者分为下肢动脉病变(Peripheral Arterial Disease,PAD)症状组(具有间歇性跛行和(或)静息性腿痛)和无PAD症状组,使用高频超声二维时分别测量静息状态下及反应性充血后胫前动脉内径(D0,D1),内-中膜厚度(Intima Media Thickness, IMT),彩色流速流量定量技术测量胫前动脉收缩期峰值血流速度(Peak systolic Velocity,PSV),搏动指数(Pulse Index,PI),血管内压力(Pression,P)及压差(Friqunent,FRQ),比较两组胫前动脉血管内皮舒张功能((D1-D0)/D0),IMT及血流参数的差异,应用多元回归分析血管内皮舒张功能及以上血流动力学参数与下肢PAD症状的相关性.结果:(1)与非PAD症状组相比,PAD症状组血管内皮舒张功能,PSV、PI、P均减低,IMT增加;(2)PAD症状与年龄、病程、糖化血红蛋白、PSV、PI、Sten%、血管内皮舒张功能等有相关性,而与IMT等无相关性.结论:(1)袖带加压法测定血管内皮依赖性舒张功能方法简便且有潜在临床适用性;(2)血管内皮舒张功能作为一项新指标可以和经典的PSV一样反映下肢动脉病变的情况,从而为下肢动脉病变的诊断提供依据.%Objective: To study the anterior tibial arterial endothelial before diastolic function and hemodynamic parameters and type 2 diabetes lower limbs the correlation of disease, type 2 diabetes lower limb artery pathological changes of ultrasound diagnosis for more theoretical basis. Methods: The institutional review board approved the study, and all patients provided signed informed consent. 159 cases of type 2 diabetic patients were divided into peripheral arterial disease (PAD) symptoms group

  18. A finite element study of balloon expandable stent for plaque and arterial wall vulnerability assessment

    Science.gov (United States)

    Karimi, Alireza; Navidbakhsh, Mahdi; Razaghi, Reza

    2014-07-01

    The stresses induced within plaque tissues and arterial layers during stent expansion inside an atherosclerotic artery can be exceeded from the yield stresses of those tissues and, consequently, lead to plaque or arterial layer rupture. The distribution and magnitude of the stresses in each component involved in stenting might be clearly different for different plaque types and different arterial layers. In this study, a nonlinear finite element simulation was employed to investigate the effect of plaque composition (calcified, cellular, and hypocellular) on the stresses induced in the arterial layers (intima, media, and adventitia) during implantation of a balloon expandable coronary stent into a stenosed artery. The atherosclerotic artery was assumed to consist of a plaque and normal/healthy arterial tissues on its outer side. The results indicated a significant influence of plaque types on the maximum stresses induced within the plaque wall and arterial layers during stenting but not when computing maximum stress on the stent. The stress on the stiffest calcified plaque wall was in the fracture level (2.38 MPa), whereas cellular and hypocellular plaques remain stable owing to less stress on their walls. Regardless of plaque types, the highest von Mises stresses were observed on the stiffest intima layer, whereas the lowest stresses were seen to be located in less stiff media layer. The computed stresses on the intima layer were found to be high enough to initiate a rupture in this stiff layer. These findings suggest a higher risk of arterial vascular injury for the intima layer, while a lower risk of arterial injury for the media and adventitia layers.

  19. 高频彩超在研究慢性肾衰竭患者颈动脉斑块及相关危险因素的应用价值%Carotid Artery Plaque and Related Metabolic Risk Factors in Patients with Chronic Renal Failure by High-resolution Color Doppler Ultrasound

    Institute of Scientific and Technical Information of China (English)

    梁新; 李泉水; 杨雪冰; 王晶; 陈洪滔; 陈海波; 吕琼芳

    2012-01-01

    目的 研究慢性肾功能衰竭(chronic renal failure,CRF)患者颈动脉斑块情况与相关危险因素的关系.方法 对43例CRF患者采用高分辨率高频彩超观察双侧颈动脉内-中膜厚度(IMT)及斑块情况,同时抽血检测血钙、磷,胆固醇、甘油三酯、二氧化碳结合力、血肌酐,并计算钙磷乘积.结果 43例CRF患者,24例(55.8%)存在颈动脉斑块.斑块组IMT值、血磷及钙磷乘积较无斑块组显著增高(分别P<0.01、P<0.05、P<0.05).结论 CRF患者颈动脉斑块的超声特征表现为高回声的钙化斑块,且多位于动脉中膜,CRF患者颈动脉钙化斑块的形成与钙磷代谢紊乱密切相关,因此可将颈动脉有无斑块作为一个筛选因素来预测CRF患者的心血管疾病病变程度.%Objective To investigate the relationship between carotid artery plaque and calcium phosphorus metabolism disorder in patients with chronic renal failure(CRF). Methods The intima-media thickness(IMT) and plaque of bilateral carotid artery were detected by ultrasonography in 43 patients with CRF and serum calcium/phosphorus, serum lipid profile,creatintne,CO2CP were checked at the same time. Results Carotid plaque was confirmed in 24 of 43 cases with CRFC55. 8%). IMT, serum phosphorus and calcium-phosphorus product were significantly higher (P< 0. 01,P<0. 05,P<0. 05 respectively) in patients with carotid plaque than those in patients without carotid plaque. Conclusions Carotid plaque was very prevalent in CRF patients. IMT, serum phosphorus and calcium phosphorus product were closely correlated with carotid plaque in such patients. Carotid plaque of CRF patients is mostly hypere-choic plaqueSf and many in the media layer. It is very important to reduce the incidence and mortality of cardiovascular disease of CRF patients with the early detection of carotid artery plaque by high-resolution color Doppler ultrasound.

  20. Artery buckling analysis using a two-layered wall model with collagen dispersion.

    Science.gov (United States)

    Mottahedi, Mohammad; Han, Hai-Chao

    2016-07-01

    Artery buckling has been proposed as a possible cause for artery tortuosity associated with various vascular diseases. Since microstructure of arterial wall changes with aging and diseases, it is essential to establish the relationship between microscopic wall structure and artery buckling behavior. The objective of this study was to developed arterial buckling equations to incorporate the two-layered wall structure with dispersed collagen fiber distribution. Seven porcine carotid arteries were tested for buckling to determine their critical buckling pressures at different axial stretch ratios. The mechanical properties of these intact arteries and their intima-media layer were determined via pressurized inflation test. Collagen alignment was measured from histological sections and modeled by a modified von-Mises distribution. Buckling equations were developed accordingly using microstructure-motivated strain energy function. Our results demonstrated that collagen fibers disperse around two mean orientations symmetrically to the circumferential direction (39.02°±3.04°) in the adventitia layer; while aligning closely in the circumferential direction (2.06°±3.88°) in the media layer. The microstructure based two-layered model with collagen fiber dispersion described the buckling behavior of arteries well with the model predicted critical pressures match well with the experimental measurement. Parametric studies showed that with increasing fiber dispersion parameter, the predicted critical buckling pressure increases. These results validate the microstructure-based model equations for artery buckling and set a base for further studies to predict the stability of arteries due to microstructural changes associated with vascular diseases and aging. PMID:27031686

  1. ИНТЕГРАЛЬНЫЙ ПОДХОД К ОЦЕНКЕ ВЗАИМОСВЯЗИ ИЗМЕНЕНИЙ ПОКАЗАТЕЛЕЙ ИММУННОГО СТАТУСА И МАРКЁРОВ НЕСПЕЦИФИЧЕСКОГО ВОСПАЛЕНИЯ ПРИ ИБС

    Directory of Open Access Journals (Sweden)

    Е. И. Соколов

    2013-01-01

    Full Text Available We carried out a comprehensive evaluation of cellular and humoral immunity, nonspecific inflammation markers and their relationship to the thickness of the intima-media of the carotid arteries and the impact of changes in these parameters on the nature of coronary artery disease. The study included 44 patients with chronic forms of coronary artery disease and 35 healthy individuals. In patients with ischemic heart disease has changed mainly of innate immunity, such as the activation of NK-cells (CD16, CD 56, CD 4+CD25+, with regulatory activity in respect of the synthesis of pro- and — inflammatory and anti-inflammatory cytokines, as well as an increase in the level of antiphospholipid antibodies, CRP and the thickness of the complex of intima-media of the carotid arteries, the degree of change in the links of the immunity reflects the severity of the disease.

  2. 兔颈总动脉不同形式剪切力及动脉粥样硬化模型的构建%The model of atherosclerosis caused by different shear stresses in the rabbit carotid artery

    Institute of Scientific and Technical Information of China (English)

    孙涛; 王颖; 马志勇; 张凯; 钟学珍; 黎莉

    2011-01-01

    Objective To explore the effects of increased, lowered and oscillatory wall shear stresses in the progress of atherosclerosis by placing the arterial cannula in the rabbit carotid artery. Method According to the theory of hydromechanics, the rabbit model of atherosclerosis was established by the arterial cannula designed by us and a high fat diet.The data was detected at three designated time points, including the common carotid arterial intima-media thickness (IMT), end diastolic diameter(Dr), systolic peak velocity(Vs), diastolic end velocity(Vd), mean velocity(Vm).Then, the shear stress was calculated. At the end of 12 weeks, the rabbits were sacrificed, and arterial samples were obtained to observe the pathological changes in common carotid artery through hematoxylin and eosin stain. Results The levels of the increased and lowered shear stresses caused by the cannula were significantly different from the basic line( both P < 0.05 ), the vascular ultrasound showed there was turbulent blood flow in the area of oscillatory shear stresses. Compared to the oscillatory shear stresses, the area of the lowered shear stress contained bigger plaques,more lipids and smooth muscle cells, but less collagen. There was no obvious plague in the area of the increased shear stress. Conclusions The cannula in the common carotid artery can induce different shear stresses, including increased,lowered and oscillatory, in different segments of a single artery. Increased shear stresses can inhibit atherosclerosis,while the lowered and oscillatory ones can boost its formation.%目的 探讨自行设计的兔颈总动脉套管产生的高、低及震荡剪切力在动脉粥样硬化斑块进程中的作用.方法 根据流体力学原理,采用自行设计的楔形颈总动脉套管加高脂饮食建立兔动脉粥样硬化模型.分3个时间点采集兔颈总动脉内膜中层厚度(IMT)、舒张末期内径(Dr)、收缩期峰值流速(Vs)、舒张期血流速度(Vd)、平均血流

  3. Evaluation of ischemic cerebrovascular lesions by ultrasonography in patients with coronary artery stenosis and its relationship with risk factors%颈动脉超声对冠状动脉狭窄患者缺血性脑血管疾病的评价及其与传统危险因素的关系

    Institute of Scientific and Technical Information of China (English)

    张蕾; 王维平; 李亚琼; 高承梅; 刘晶; 李晓辉

    2012-01-01

    Objective To evaluate the value for predicting cerebrovascular stenosis in patients with coronary artery stenosis via carotid ultrosonography and its advantages than traditional risk factors. Methods CDFI and TCD were used to examine the carotid artery and intracranial artery respectively for the 209 patients whose diagnosis of coronary artery stenosis(≥70% ) via selective coronary angiography. The patients were divided into carotid stenosis and non - carotid stenosis groups as well as intracranial artery stenosis and non - intracranial artery stenosis groups. The risk factor variables were evaluated in the stenosis and non - stenosis groups respectively. Results Carotid ultrasound findings were more sensitive for predicting the ischemic heart and cerebralvascular disease than traditional risk factors. Conclusion The carotid maximum intima - media thickness (IMT) , hypertension, plaque number, heterogeneous plaque and multiple plaques seems to increase the risk for ischemic cerebralvascular disease of coronary artery stenosis. Elucidate the relationship between the risk factors of intracranial and extra - cranial artery stenosis with coronary artery stenosis. Therefore, it is important for patient management and evaluation of therapies for stroke prevention . CDFI should be applied for ischemic coronary artery diseases patients.%目的 探讨颈动脉超声对预测冠状动脉狭窄患者颅内动脉狭窄的价值,以及颈动脉超声相对于其它动脉粥样硬化主要危险因素预测缺血性心脑血管疾病的优越性.方法 对209例经血管造影证实冠状动脉狭窄(≥70%)的患者采用彩色多谱勒血流成像(CDFI)和经颅多普勒超声(TCD)分别检查颈动脉和颅内动脉,并将患者分为颈动脉狭窄组与非狭窄组;脑动脉狭窄组与非狭窄组,分别比较狭窄组与非狭窄组之间的危险因素及生化指标,进一步对冠状动脉狭窄合并颅内动脉狭窄的主要危险因素与颈动脉超声结果中

  4. Evaluation of femoral artery elasticity in passive smokers and active smokers by E - tracking technology%血管回声跟踪技术评价主动与被动吸烟者股动脉弹性的研究

    Institute of Scientific and Technical Information of China (English)

    乞艳华; 郑转梅; 周琦; 雷晓莹

    2011-01-01

    目的 探讨血管回声跟踪(ET)技术评价主动吸烟者与被动吸烟者股动脉血管弹性功能的应用价值.方法 利用ET技术检测40例主动吸烟者、40例被动吸烟者、40例健康对照组的股动脉,通过内-中膜厚度(IMT)、僵硬度(β)、压力-应变弹性系数(Eρ)、动脉顺应性(AC)、脉搏波放大指数(AI)及脉搏波传导速度(PWVβ)评价动脉硬化程度.结果主动吸烟组AI、PWVβ高于被动吸烟组,差异有统计学意义(P<0.05);主动吸烟组、被动吸烟组β和Eρ均高于对照组,差异有统计学意义(P<0.05); 主动吸烟组、被动吸烟组AC均低于对照组,差异有统计学意义(P<0.01).结论 ET技术可早期发现被动吸烟者和主动吸烟者股动脉弹性功能的改变,测量结果精确,是一种无创、便捷的检查方法.%Objective To explore the application value of E - tracking technology (ET) in evaluating femoral artery elasticity in passive smokers and active smokers. Methods Forty active smokers, 40 passive smokers and 40 normal persons (the control group) were enrolled in this study. The arteriosclerosis degree was evaluated by (intima- media thickness) IMT,pressure- strain elastic modulus (Ep), stiffness parameters (β), arterial compliance (AC), pulse amplification index (Al),Pulse wave transmission speed(PWVβ). Results Al and PWVβ in active smoking group were higher than those in passive smoking group, while βand Eρ in active smoking group and passive smoking group were higher than those in normal control group (P <0.05), there was significant difference. AC was lower in passive and active smokers than that in normal control group,there was significant difference ( P < 0.01 ). Conclusion As a convenient and non - invasive method, ET can be used to access the vessel dysfunction of passive and active smokers accurately.

  5. Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits

    Directory of Open Access Journals (Sweden)

    Baroncini Liz

    2008-05-01

    Full Text Available Abstract Background The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries. Methods White male rabbits were fed a hypercholesterolemic diet for 6 weeks and divided into two groups as follows: rosiglitazone group, 14 rabbits treated with rosiglitazone (3 mg/Kg body weight/day during 6 weeks; and control group, 18 rabbits without rosiglitazone treatment. All animals underwent balloon catheter injury of the right iliac artery on the fourteenth day of the experiment. Results There was no significant difference in intima/media layer area ratio between the control group and the rosiglitazone group. Rosiglitazone did not reduce the probability of lesions types I, II, or III (72.73% vs. 92.31%; p = 0.30 and types IV or V (27.27% vs. 7.69%; p = 0.30. There were no differences in the extent of collagen type I and III deposition or in the percentage of animals with macrophages in the intima layer. The percentage of rabbits with smooth muscle cells in the intima layer was higher in rosiglitazone group (p = 0.011. Conclusion These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site.

  6. Increased carotid thickness in subjects with recently-diagnosed diabetes from rural Cameroon.

    Directory of Open Access Journals (Sweden)

    Nicola Napoli

    Full Text Available BACKGROUND: We have recently shown a high prevalence of diabetes and obesity in rural Cameroon, despite an improved lifestyle. Diabetes in rural Africa remains underdiagnosed and its role in increasing risk of atherosclerosis in these populations is unknown. We investigated the prevalence of carotid atherosclerosis and cardiovascular risk factors in a population of subjects with recently-diagnosed diabetes from rural Cameroon. METHODOLOGY/PRINCIPAL FINDINGS: In a case-control study, carotid intima-media thickness (IMT was measured in 74 subjects with diabetes (diagnosed 0.9 mm was found in 4%, 45.9% and 20% of diabetic subjects at the common, bulb or internal carotid, respectively. Only 25% of patients had an HbA1c9%. The prevalence of diabetic subjects with abnormal levels of LDL-cholesterol, triglycerides, HDL-cholesterol or blood pressure was 45%, 16.6%, 15% and 65.7%, respectively. CONCLUSIONS: Carotid thickness is increased in subjects with diabetes from a rural area of Cameroon, despite the relatively recent diagnosis. These findings and the high rate of uncontrolled diabetes in this population support the increasing concern of diabetes and cardiovascular diseases in African countries and indicate the need for multifaceted health interventions in urban and rural settings.

  7. Increased Carotid Thickness in Subjects with Recently-Diagnosed Diabetes from Rural Cameroon

    Science.gov (United States)

    Napoli, Nicola; Zardi, Enrico; Strollo, Rocky; Arigliani, Michele; Daverio, Andrea; Olearo, Flaminia; Tosi, Daniele; Dicuonzo, Giordano; Scarpa, Filomena; Pedone, Claudio; Tegue Simo, Hervé Hilaire; Mottini, Giovanni; Pozzilli, Paolo

    2012-01-01

    Background We have recently shown a high prevalence of diabetes and obesity in rural Cameroon, despite an improved lifestyle. Diabetes in rural Africa remains underdiagnosed and its role in increasing risk of atherosclerosis in these populations is unknown. We investigated the prevalence of carotid atherosclerosis and cardiovascular risk factors in a population of subjects with recently-diagnosed diabetes from rural Cameroon. Methodology/Principal Findings In a case-control study, carotid intima-media thickness (IMT) was measured in 74 subjects with diabetes (diagnosed 0.9 mm was found in 4%, 45.9% and 20% of diabetic subjects at the common, bulb or internal carotid, respectively. Only 25% of patients had an HbA1c9%). The prevalence of diabetic subjects with abnormal levels of LDL-cholesterol, triglycerides, HDL-cholesterol or blood pressure was 45%, 16.6%, 15% and 65.7%, respectively. Conclusions Carotid thickness is increased in subjects with diabetes from a rural area of Cameroon, despite the relatively recent diagnosis. These findings and the high rate of uncontrolled diabetes in this population support the increasing concern of diabetes and cardiovascular diseases in African countries and indicate the need for multifaceted health interventions in urban and rural settings. PMID:22916106

  8. 超声评价高血压对左心室舒张功能和动脉顺应性的影响%Evaluating the impact of hypertension on left ventricular diastolic function and arterial compliance with ultrasound imaging

    Institute of Scientific and Technical Information of China (English)

    朱栋晓; 王晓彦; 施晶晶; 刘小铭; 黄国倩

    2012-01-01

    目的 应用超声成像技术评价高血压对左室(LV)舒张功能及动脉顺应性的影响.方法 原发性高血压(EH)患者70例分为LV构型异常(A组,28例)和正常(B组,42例)两组.70例正常人作为对照组(C组).A、B组应用超声心动图测定左房室内径、LV壁厚度和相对室壁厚度、LV质量指数、LV射血分数;记录二尖瓣口的血流频谱(E、A)和二尖瓣环的组织运动速度(e'、a'),计算E/e’;测左侧颈总动脉内中膜厚度、最大及最小径,计算颈动脉顺应性(AC)、血管僵硬参数(β)及压力应变弹性系数(Ep).结果 A组的左房、室较B组及C组扩大(P<0.05).A、B组E/e'高于C组(P<0.05),e’/a’低于C组(P<0.05),A组E/A低于B组和C组(P<0.05).A、B组IMT、β、Ep高于C组,AC低于C组(P<0.05);A组的βEp高于B组(P<0.05).结论 EH可致LV舒张功能及动脉顺应性降低;组织多普勒评价LV舒张功能优于二尖瓣血流频谱.%Objective To evaluate the impact of hypertension on left ventricular (LV) diastolic function and arterial compliance with ultrasound imaging. Methods Seventy patients with essential hypertension(EH) were divided into two groups of A(28 cases,with abnormal LV geometry) and B (42 cases.with normal LV geometry). Seventy healthy people were taken as the controls (group C). The left atrial(LA) and LV diameters, wall thickness and relative wall thickness,left ventricular mass index and left ventricular ejection fraction were measured by echocardiography. The mitral valve flow pattern(E,A) and mitral annulus tissue velocity(e',a') were recorded and E/e' was calculated. The left common carotid artery intima-media thickness and carotid diameter were measured and the carotid arterial compliance(AC), vascular stiffness parameters(β) and pressure-strain elasticity modulus(Ep) were calculated. Results LA and LV of group A were dilated compared with those of group B and group C(P<0. 05). The E/e' was higher, but e'/a' was

  9. 2型糖尿病颈动脉内膜中层厚度相关因素研究%The Study of the Correlation Factors of Carotic Intima-media Thickness(IMT) in Patients With Type 2 Diabetes Meltltus

    Institute of Scientific and Technical Information of China (English)

    吴娟; 刘东方

    2011-01-01

    目的 探讨2型糖尿病患者颈动脉内膜中层厚度(IMT)的相关因素.方法 检测 176例2型糖尿病患者的IMT、甘油三酯(TG)、总胆固醇(TC)、高密度蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后2 h血糖(2hPG)、空腹胰岛素(FINS)、尿微量白蛋白(UAER)、尿微量白蛋白/尿肌酐(Ualb/Cr)值,计算胰岛素抵抗指数(InHOMA-IR),并将IMT与其他因素作相关及多元逐步回归分析.结果 IMT与2hPG、TG、TC、LDL-C、FINS、InHOMA-IR、UAER、Ualb/Cr呈正相关(P<0.05或P<0.01),与HDL-C呈负相关(P<0.01),与FBG、HbA1c不相关(P>0.05).进入多元线性回归方程的变量为2hPG、LDL-C、BMI、InHOMA-IR、UAER、Ualb/Cr、HDL-C.结论 2型糖尿病患者2hPG、TG、TC、LDL-C、FINS、InHOMA-IR、UAER、Ualb/Cr 影响IMT,应针对这些相关因素进行干预,预防或延缓糖尿病大血管并发症.

  10. 老年高血压患者动态脉压与心肌重塑、颈动脉硬化及尿蛋白的关系%The relationship ambulatory pulse pressure、remodeling、carotic intima-media thickness and albuminuia(AB)in elderly people with essential hypertension

    Institute of Scientific and Technical Information of China (English)

    朱吉基; 杨澜

    2012-01-01

    目的 探讨老年原发性高血压患者脉压与心肌重塑、颈动脉硬化及尿蛋白的关系.方法 将140例老年原发性高血压患者分别测定24小时动态血压、超声心动图、颈动脉超声及24小时尿蛋白水平,根据脉压的不同,分为三组:A组(脉压≤40mmHg)33例;B组(脉压41-60mmHg)45例;C组(脉压>60mmHg)62例;分析各组间左室重量指数、颈动脉内-中膜厚度及尿蛋白水平.结果 各组间性别、年龄、血脂异常情况均无显著性差异(p>0.05),随着脉压增高,左室重量指数、颈动脉内-中膜厚度、24小时尿白蛋白量均增加.结论 老年高血压患者脉压增高可导致左室肥厚,加重颈动脉硬化,尿白蛋白水平增高.

  11. 颈动脉内膜-中层厚度与2型糖尿病相关危险因素分析%Study of Carotic Intima-Media Thickness and Risk Factors in Patients with Type 2 Diabetes Mellitus

    Institute of Scientific and Technical Information of China (English)

    王巍; 梁伟; 曹久妹; 李菲卡

    2005-01-01

    目的研究2型糖尿病患者颈动脉内膜-中层厚度(IMT)的改变,探讨其与各种相关危险因素的关系.方法141例2型糖尿病患者分为合并高血压组(n=70)和非高血压组(n=71),采用高分辨率彩色多普勒超声显像仪测量颈动脉IMT,同时测定相关危险因素并进行统计学分析.以71例老年健康体检者作为正常对照组.结果糖尿病非高血压组和合并高血压组IMT、血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后血糖(PBG)和胰岛素敏感性(ISI)均显著高于正常对照组.糖尿病合并高血压组IMT、TC、LDL-C、FPG显著高于非高血压组.结论糖尿病和高血压同时存在加速动脉粥样硬化的进程.IMT测量对2型糖尿病心脑血管疾病高危患者,具有早期发现和筛选作用.

  12. Effect of HbA1c on the carotid intima-media thickness under the multifactorial intervention in newly diagnosed type 2 diabetes%多因素干预下糖化血红蛋白对新诊2型糖尿病患者颈动脉内中膜厚度的影响

    Institute of Scientific and Technical Information of China (English)

    蒋江卫; 朱苗飞; 黎佩珊; 黄秀娟; 梁雪玲; 陈银侃; 林绍静

    2008-01-01

    目的 探讨多危因素强化干预条件下,糖化血红蛋白(HbA1c)水平对新诊2型糖尿病(T2DM)患者颈总动脉内中膜厚度(CCA-IMT)的预测作用.方法 对90例病程1年以内的T2DM患者进行以抗血小板聚集为基础的强化血糖、血压、血脂及体重等综合干预治疗,以△CCA-IMT值是否≥0.02 mm为界限,将T2DM患者分为CCA-IMT增厚组及非增厚组,比较强化干预1年前、后2组患者间代谢指标的差异及其与CCA-IMT增厚的关系.采用Logistic回归分析探讨影响CCA-IMT增厚的危险因素.结果 经1年多因素强化治疗后,90例新诊T2DM患者中CCA-IMT增厚组患者24例,非增厚组66例;CCA-IMT增厚组患者有吸烟史、饮酒史、高血脂史、高血压史的比例及患者的年龄显著高于非增厚组患者(P<0.05);CCA-IMT增厚组患者HbA1c的下降幅度即△HbA1c[0.20(5.90~-2.80)∶1.20(9.30~-2.70)]明显小于非增厚组(P<0.05); Logistic回归分析结果显示与CCA-IMT增厚密切关联的因素有年龄、△HbA1c.结论 对新诊T2DM采取多危因素强化干预条件下,HbA1c的下降幅度能够预测CCA-IMT的进展.

  13. 血压正常高值人群动脉血管功能和结构变化的研究%The change of artery elastic function and structure in persons with high-normal blood pressure

    Institute of Scientific and Technical Information of China (English)

    胡明昕; 高金颖

    2014-01-01

    目的:利用无创方法探讨血压正常高值人群动脉血管功能和结构的变化。方法应用博时全自动动脉硬化检测系统及超声诊断仪对349例血压正常高值人群进行踝臂指数(ABI)、臂-踝脉搏波传导速度(baPWV)、颈动脉内膜中层厚度(IMT)的检测,并与同期受检的201例血压正常人群、303例原发性高血压1级患者及77例原发性高血压2级患者的检测结果进行对比研究。结果正常高值血压组受检人群脉搏波传导速度、颈动脉内膜中层厚度的异常检出率较正常血压组明显增高,而低于原发性高血压1、2级组,且正常高值血压组、原发性高血压1、2级组分别与正常血压组相比,差异均有统计学意义(P<0.0083);而踝臂指数异常的检出率均较低,正常血压组、正常高值血压组、原发性高血压1级组之间无统计学差异(P>0.0083),但以上三组分别与原发性高血压2级组比较差异均有统计学意义(P<0.0083)。结论血压正常高值人群尚未发展至高血压阶段时已经开始出现动脉血管功能和结构的损害,表现为血管顺应性下降,僵硬度增加,动脉内膜增厚,斑块形成,甚至出现管腔狭窄及堵塞等一系列病理改变。%ObjectiveTo explore the artery elastic function and structure changes in high-normal blood pressure persons by non-invasive examination.MethodsThe Intima-media thickness (IMT) were detected, meanwhile, the Ankle-Brachial Index(ABI) and Pulse Wave Velocity (PWV) were measured in 349 prehypertensive people using Boso(BOSCH+SONH) automatic arteriosclerosis measurement system, and were compared with normotensive group(n=201), hypertension grade 1 group(n=303) and hypertension grade 2 group(n=77).Results The level of PWV and IMT in the high-normal blood pressure group were significantly higher than those of the normal blood pressure group and lower than hypertension grade 1 and 2

  14. Vitamin D deficiency is associated with atherosclerosis-promoting risk factor clustering but not vascular damage in children

    OpenAIRE

    Cheraghi, Nikoo; Dai, Hongying; Raghuveer, Geetha

    2012-01-01

    Summary Background Vitamin D has been associated with multiple cardiometabolic risk factors in children but there is a paucity of studies examining its correlation to vascular function and structure. Our objective was to determine whether there is a correlation between vitamin D, cardiometabolic risk, vascular distensibility and carotid artery intima-media thickness (CIMT) in high-risk children. Material/Methods This was a cross-sectional, cohort study that compared vitamin D to cardiometabol...

  15. Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults.

    LENUS (Irish Health Repository)

    Anderwald, Christian

    2010-08-01

    Insulin resistance (IR) is implicated as an independent risk factor for vascular disease. The aim of this study was to assess the impact of family history (FH) of type 2 diabetes (T2DM) and\\/or cardiovascular disease (CVD) on the associations between IR, low-density-lipoprotein cholesterol (LDL-C) and subclinical atherosclerosis (common and internal carotid artery intima media thickness (IMT)) in healthy European adults.

  16. Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study

    OpenAIRE

    Zoran Gluvic; Emina Sudar; Jelena Tica; Aleksandra Jovanovic; Sonja Zafirovic; Ratko Tomasevic; Isenovic, Esma R.

    2015-01-01

    The aim of this study was to investigate the effect of levothyroxine (LT4) replacement therapy during three months on some parameters of metabolic syndrome and atherosclerosis in patients with increased thyroid-stimulating hormone (TSH) level. This study included a group of 30 female patients with TSH level >4 mIU/L and 15 matched healthy controls. Intima media complex thickness (IMCT) and peak systolic flow velocity (PSFV) of superficial femoral artery were determined by Color Doppler scan. ...

  17. Inflammatory markers and extent and progression of early atherosclerosis

    DEFF Research Database (Denmark)

    Willeit, Peter; Thompson, Simon G; Agewall, Stefan;

    2016-01-01

    BACKGROUND: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA...... in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis....

  18. Relation between visceral fat and carotid intimal media thickness in Mexican postmenopausal women: a preliminary report

    Science.gov (United States)

    Azpilcueta, Yessica Mireya Moreno; Ortiz, Sergio Rosales

    2016-01-01

    Aim of the study To investigate the relationship between visceral fat and carotid IMT (intima media thickness) in Mexican postmenopausal women. Material and methods In 71 postmenopausal women divided in two groups: group 1, IMT > 1 mm and group 2, IMT ≤ 1 mm, blood pressure, body mass index (BMI), waist hip ratio (WHR), visceral and subcutaneous fats and carotid IMT were analyzed. Descriptive statistics were used and the comparison among those with abnormal and normal IMT was carried out using Mann-Whitney U test; also Spearman's correlation analysis was done. Results When comparing group 1 (n = 9, 12.7%) with group 2 (n = 62, 87.3%), it was found that the subcutaneous fat, visceral fat and systolic blood pressure were significantly greater in group 1 (p < 0.018, p < 0.001 and p < 0.006, respectively), and also in this group there was a correlation between BMI and subcutaneous fat (ρ = 0.686, p < 0.041) and between visceral fat and the systolic blood pressure (ρ = 0.712, p < 0.031). In group 2, there was a correlation between IMT and diastolic blood pressure (ρ = 0.251, p < 0.049). Conclusion Subcutaneous and visceral fat have an unfavorable effect in the carotid IMT and in blood pressure.

  19. 高血压患者颈动脉结构和功能改变的超声研究%Ultrasonic study on the structural and functional changes of carotid artery in patients with hypertension

    Institute of Scientific and Technical Information of China (English)

    宋涛; 宋敏; 李勇; 时培苗; 王薇

    2015-01-01

    Objective To investigate the characteristic of carotid artery remodeling of patients who suffered from hypertension (HTN) with left ventricular hypertrophy (LVH).Methods One hundred and forty cases were chosen,50 HTN patients without LVH (NLVH),50 HTN patients also with LVH (LVH),40 healthy individuals.They were all assessed the carotid artery (CA)intima-media thickness (IMT),plaque and plaque score,elasticity coefficient (EC),stiffness coefficient (β),compliance (CA) and hemodynamic parameters of common carotid artery (CCA) and internal carotid artery (ECA).Results Compared with healthy individuals,the change of the CA internal dameter and CA-IMT,plaque detectable rate and score,EC and β were all increased,but the CA decreased.The differences between groups were significant (P < 0.05).In terms of the hemodynamic parameters,peak systolic velocity (PSV) and end diastolic velocity (EDV) were reduced,pulsatility index (PI) and resistance index (RI) rised(P < 0.05).Conclusions As to HTN patients,the remodeling and functional change of CA are closely related with the LVH.%目的 探讨高血压(HTN)伴左室肥厚(LVH)患者颈动脉重构的特点及两者之间的关系.方法 140例受检者入选本研究,其中高血压非左室肥厚(NLVH) 50例,高血压伴左室肥厚(LVH)50例,体检健康者对照组40例,分别测量颈动脉内-中膜厚度(CA-IMT)、斑块和斑块积分、弹性系数(EC)、僵硬系数(β)、顺应性(AC)以及颈总动脉(CCA)、颈内动脉(ECA)的血流动力学参数.结果 与对照组比较,高血压组CA内径、CA-IMT、斑块检出率和斑块积分明显增加,而且颈动脉EC及β增高,AC降低,组间比较差异有统计学意义(P<0.05);血流动力学指标表现为收缩期峰值流速、舒张末期流速降低,搏动指数和阻力指数均增高,且均以LVH组改变最显著,组间比较差异有统计学意义(P<0.05).结论 高血压患者CA-IMT、斑块增加、顺应性降低以及血流动力学改变与LVH密切相关.

  20. The effect of new-onset diabetes after renal transplantation on arterial stiffness%肾移植术后新发糖尿病的危险因素及其对动脉僵硬度的影响

    Institute of Scientific and Technical Information of China (English)

    刘航; 史屹; 沈中阳

    2009-01-01

    目的 探讨肾移植术后新发糖尿病(NODAT)的影响因素以及动脉僵硬度与移植术后新发糖尿病之间的相关性.方法 195例肾移植患者,根据糖耐量检查的结果分为NODAT与非NODAT两组.应用动脉硬化检测仪检测患者的肱一踝脉搏波传导速度(baPWV)、踝肘血压指数(ABPI)以及颈动脉内膜中层厚度(IMT),同时对入选对象进行血清学检测,根据动脉僵硬度指标分析两组之间的差异.结果 29例移植术后诊断为NODAT,与非NODAT患者相比,移植术前的空腹血糖(FPG)、血压以及丙型肝炎病毒(HCV)感染率都处于一个相当高的水平.多变量回归分析提示,术前HCV感染率、FPG水平以及收缩压是关系到NODAT发生的危险因素.NODAT患者的baPWV明显快于非NODAT患者,同时高血压、年龄以及术后糖化血红蛋白是动脉僵硬度进展的独立决定性因素.结论 肾移植术前高水平的FPG、HCV感染以及持续的高血压状态是引起NODAT的危险因素;高血压、年龄偏大以及糖化血红蛋白升高对动脉僵硬度的进展具有重要影响.%Objective To investigate the risk factor for new-onset diabetes after transplantation (NODAT) and the relationship between NODAT and arterial stiffness. Methods Oral glucose tolerance test (OGTT) was performed on 195 patients with renal transplantation. The degree of arterial stiffness, which was determined by brachial ankle pulse wave velocity (baPWV), anklebrachial blood pressure index (ABPI) and intima-media thickness (IMT) of the carotid artery, was evaluated. Results Twenty-nine patients diagnosed as NODAT had significantly higher fasting plasma glucose before transplantation, blood pressure and incidence of hepatitis C virus (HCV) infection than in patients without NODAT. Multivariate regression analysis revealed that the risk factor of NODAT was fasting plasma glucose pre-transplantation, HCV infection and systolic blood pressure.The independent determinant of the

  1. Transcutaneous oximetry but not arterial toe blood pressure or ankle-brachial index is related to macular thickness in patients with chronic diabetic foot ulcers

    Directory of Open Access Journals (Sweden)

    Per Katzman

    2013-04-01

    Full Text Available Objectives: Diabetes related vascular complications of the lower extremity could be classified as micro- and macrovascular. Ankle-brachial index (ABI and toe blood pressure (TBP measurements evaluate macro-circulation, whereas transcutaneous oximetry (TcPO2 is considered to be a composite measure of vascular function, thereby also reflecting microcirculation. Microvascular disease in the eye involves abnormal capillary permeability and possibly thereby increased macular thickness. The aim of the present clinical study was to evaluate if microvascular disease in the eye was related to measures of foot ischemia in patients with diabetes mellitus. Methods: Twenty consecutive patients with diabetes and chronic full-thickness foot ulcers were included. Peripheral ischemia was diagnosed using TcPO2, TBP and ABI. Macular thickness was measured with optical coherence tomography technique. Results: Based on TcPO2, TBP and ABI measurements 14, 13 and 13 patients, respectively, were classified as ischemic. Patients with ischemic TcPO2 levels at the dorsum of the foot had significantly higher macular thicknesses. This was not the case in patients with ischemic TBP or ABI levels. Conclusion: TcPO2, unlike TBP and ABI, seems to be a clinically relevant measure of peripheral microvascular disease in patients with diabetes mellitus and may, if low, indicate an increased risk of macular edema. [J Exp Integr Med 2013; 3(2.000: 81-85

  2. Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype.

    Science.gov (United States)

    Nakaso, Kazuhiro; Yasui, Kenichi; Kowa, Hisanori; Kusumi, Masayoshi; Ueda, Keigo; Yoshimoto, Yuko; Takeshima, Takao; Sasaki, Kiyohiro; Nakashima, Kenji

    2003-03-15

    In recent years, an intense interest has developed in the association between Parkinson's disease (PD) and hyperhomocysteinemia. Homocysteine (Hcy) is a neuronal excitotoxic amino acid, and is well known as a risk factor for vascular diseases. Some reports suggest that the administration of L-DOPA may promote hyperhomocysteinemia and idiopathic atherosclerosis. In this study, we report that a mild hypertrophy of the intima-media complex (IMC) of the carotid artery, which has been established as a marker for systemic atherosclerosis, is observed in PD patients compared with normal subjects. PD patients that were treated with L-DOPA for long durations showed a hypertrophic IMC, while the patients that were not treated with L-DOPA did not show any hypertrophic changes in the IMC. These hypertrophic changes were observed primarily in patients with a Hoehn-Yahr stage of 3-5. PD patients with hypertrophic IMC of the carotid artery also exhibited elevated plasma levels of Hcy associated with the C677T genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR). Moreover, a prolonged duration of treatment with L-DOPA in patients with MTHFR T/T genotype enhanced the hypertrophy of IMC, compared with patients with the C/C or C/T genotype. These results suggest that hyperhomocysteinemia promoted by the C677T genotype of MTHFR and prolonged treatment with L-DOPA enhances atherosclerosis in PD patients and affects their general condition.

  3. Blood pressure rhythmicity and visceral fat in children with hypertension.

    Science.gov (United States)

    Niemirska, Anna; Litwin, Mieczysław; Feber, Janusz; Jurkiewicz, Elżbieta

    2013-10-01

    Primary hypertension is associated with disturbed activity of the sympathetic nervous system and altered blood pressure rhythmicity. We analyzed changes in cardiovascular rhythmicity and its relation with target organ damage during 12 months of antihypertensive treatment in 50 boys with hypertension (median, 15.0 years). The following parameters were obtained before and after 12 months of antihypertensive treatment: 24-hour ambulatory blood pressure, left ventricular mass, carotid intima-media thickness, and MRI for visceral and subcutaneous adipose tissue. Amplitudes and acrophases of mean arterial pressure and heart rate rhythms were obtained for 24-, 12-, and 8-hour periods. After 1 year of treatment, 68% of patients were normotensive, and left ventricular mass and carotid intima-media thickness decreased in 60% and 62% of patients, respectively. Blood pressure and heart rate rhythmicity patterns did not change. Changes in blood pressure amplitude correlated with the decrease of waist circumference (P=0.035). Moreover, the decrease of visceral fat correlated with the decrease of 24-hour mean arterial pressure and heart rate acrophases (both Pblood pressure and heart rate rhythms between patients who achieved or did not achieve normotension and regression of left ventricular mass and carotid intima-media thickness. It was concluded that abnormal cardiovascular rhythmicity persists in children with primary hypertension despite effective antihypertensive treatment, which suggests that it may be the primary abnormality. The correlation between changes in cardiovascular rhythmicity and visceral obesity may indicate that the visceral fat plays an important role in the sympathetic activity of adolescents with hypertension.

  4. 心踝血管指数、踝臂指数与颈动脉超声检查在体检中的相关性分析%Relationship between cardio-ankle vascular index,ankle brachial index and carotid artery ultrasonography in physical examination

    Institute of Scientific and Technical Information of China (English)

    徐宁; 田利源; 卢丽琨; 高镇北

    2014-01-01

    目的:研究心踝血管指数(CAVI)、踝臂指数(ABI)与颈动脉超声检查结果的相关性及这些指标在体检筛查动脉硬化上的应用。方法对481例体检人员进行CAVI、ABI、颈动脉超声检查,对结果的相关性进行统计学分析。结果相对于ABI,CAVI与颈动脉内中膜厚度(IMT)相关度更高(r=0.437,P=0.001),超声检出颈动脉斑块与未检出斑块的人群CAVI、ABI均有显著性差异(P<0.05);CAVI正常与异常人群比较, ABI无显著性差异,而IMT、颈动脉斑块阳性率均有显著性差异。结论 CAVI和ABI与颈动脉超声检查结果均有相关性,针对不同性别、年龄、身高、体重给出CAVI的正常值范围对于早期诊断动脉硬化更为敏感,但各个指标之间不能相互替代,需要进行综合判断。%Objective To investigate the relationship between cardio-ankle vascular index(CAVI),ankle brachial index (ABI) and carotid ultrasonic examination results and their application in physical examination for screening arteriosclerosis. Methods Cardio ankle vascular index,ankle brachial index were measured and carotid artery ultrasonography was checked in 481 people. Correlation of the results was statistically analyzed. Results Compared with ABI,CAVI was more relevant to the carotid artery intima-media thickness(IMT), r=0.437,P=0.001. CAVI and ABI had significant differences between carotid artery plaque and no plaque group tested by ultrasound (P<0.05). There was no significant difference in ABI between normal CAVI group compared with the abnormal group,while IMT and the positive rate of carotid artery plaque were significantly different(P<0.05). Conclusion CAVI and ABI are relevant with the result of carotid artery ultrasound test. CAVI normal ranges given according to different gender,age,height,weight are more sensitive for early diagnosis of arteriosclerosis. But all the indexes can not replace each other. The results should be

  5. Imaging of inflamed carotid artery atherosclerotic plaques with the use of {sup 99m}Tc-HYNIC-IL-2 scintigraphy in end-stage renal disease patients

    Energy Technology Data Exchange (ETDEWEB)

    Opalinska, Marta; Pach, Dorota; Sowa-Staszczak, Anna; Glowa, Boguslaw; Hubalewska-Dydejczyk, Alicja [Jagiellonian University Medical School, Nuclear Medicine Unit, Department of Endocrinology, Cracow (Poland); Stompor, Tomasz [University of Warmia and Mazury in Olsztyn, Department of Nephrology, Hypertensiology and Internal Medicine, Faculty of Medicine, Olsztyn (Poland); Mikolajczak, Renata; Garnuszek, Piotr; Maurin, Michal; Karczmarczyk, Urszula [National Centre for Nuclear Research Radioisotope Centre POLATOM, Otwock (Poland); Fedak, Danuta [Jagiellonian University Medical School, Clinical Biochemistry, Cracow (Poland); Krzanowski, Marcin; Sulowicz, Wladyslaw [Jagiellonian University Medical School, Department of Nephrology, Cracow (Poland); Rakowski, Tomasz [Jagiellonian University Medical School, 2nd Department of Cardiology, Institute of Cardiology, Cracow (Poland)

    2012-04-15

    Identification of vulnerable plaques remains crucial for better cardiovascular risk assessment. At least 20% of inflammatory cells within unstable (vulnerable) plaques comprise T lymphocytes, which contain receptors for interleukin-2 (IL-2); those receptors can be identified by scintigraphy with radiolabelled IL-2.The aim of this study was to identify the ''inflamed'' (vulnerable) plaques by scintigraphy using IL-2 labelled with {sup 99m}Tc in the selected, high cardiovascular risk group of end-stage renal disease (ESRD) patients. A total of 28 patients (18 men, 10 women, aged 55.2 {+-} 9.6 years, 17 on peritoneal dialysis, 11 on haemodialysis) underwent common carotid artery (CCA) scintigraphy with the use of {sup 99m}Tc-hydrazinonicotinamide (HYNIC)-IL-2. In all cases, ultrasound examination of the CCA was performed and levels of selected proinflammatory factors, atherogenic markers and calcium-phosphate balance parameters were measured. Finally, the target to non-target (T/nT) ratio of IL-2 uptake in atherosclerotic plaques with intima-media thickness (IMT), classic cardiovascular risk factors and concentrations of the measured factors were compared. Increased {sup 99m}Tc-HYNIC-IL-2 uptake in atherosclerotic plaques in 38/41 (91%) cases was detected. The median T/nT ratio of focal {sup 99m}Tc-HYNIC-IL-2 uptake in atherosclerotic plaques was 2.35 (range 1.23-3.63). The mean IMT value on the side of plaques assessed by scintigraphy was 0.79 {+-} 0.18 mm (median 0.8, range 0.5-1.275). Correlations between T/nT ratio and homocysteine (R = 0.22, p = 0.037), apolipoprotein B (apoB) (R = 0.31, p = 0.008), apoB to apoA-I ratio (R = 0.29, p = 0.012) and triglyceride concentration (R = 0.26, p = 0.021) were detected. A lower T/nT ratio in patients with better parameters of nutritional status (haemoglobin, albumin, adiponectin) in comparison with patients with worse nutritional parameters (3.20 {+-} 0.5 vs 2.16 {+-} 0.68, p = 0.025) was revealed as well

  6. Common carotid artery wall thickness and external diameter as predictors of prevalent and incident cardiac events in a large population study

    Directory of Open Access Journals (Sweden)

    Bursac Zoran

    2007-03-01

    Full Text Available Abstract Background Arterial diameters enlarge in response to wall thickening, plaques, and many atherosclerotic risk factors. We hypothesized that right common carotid artery (RCCA diameter would be independently associated with cardiac disease and improve risk discrimination. Methods In a middle-aged, biracial population (baseline n = 11225, we examined associations between 1 standard deviation increments of baseline RCCA diameter with prevalent myocardial infarction (MI and incident cardiac events (MI or cardiac death using logistic regression and Cox proportional hazards models, respectively. Areas under the receiver operator characteristic curve (AUC were used to estimate model discrimination. Results MI was present in 451 (4% participants at baseline (1987–89, and incident cardiac events occurred among 646 (6% others through 1999. Adjusting for IMT, RCCA diameter was associated with prevalent MI (female OR = 2.0, 95%CI = 1.61–2.49; male OR = 1.16, 95% CI = 1.04–1.30 and incident cardiac events (female HR = 1.75, 95% CI = 1.51–2.02; male HR = 1.27, 95% CI = 1.15–1.40. Associations were attenuated but persisted after adjustment for risk factors (not including IMT (prevalent MI: female OR = 1.73, 95% CI = 1.40–2.14; male OR = 1.14, 95% CI = 1.02–1.28, and incident cardiac events: female HR = 1.26, 95% CI = 1.08–1.48; male HR = 1.19, 95% CI = 1.08–1.32. After additional adjustment for IMT, diameter was associated with incident cardiac events in women (HR = 1.18, 95% CI = 1.00–1.40 and men (HR = 1.17, 95% CI = 1.06–1.29, and with prevalent MI only in women (OR = 1.73; 95% CI = 1.37–2.17. In women, when adjustment was limited, diameter models had larger AUC than other models. Conclusion RCCA diameter is an important correlate of cardiac events, independent of IMT, but adds little to overall risk discrimination after risk factor adjustment.

  7. The application of QLAB and sono CT in the vascular pathology of carotical artery in patients with type2 DM%超声定量技术及Sono CT在2型糖尿病颈动脉病变中的应用

    Institute of Scientific and Technical Information of China (English)

    龚丽娜; 胡建群

    2011-01-01

    目的:探讨超声内-中膜自动测量技术(QLAB)和实时复合成像(Sono CT)对2型糖尿病颈动脉病变检测的价值.方法:对124例2型糖尿病患者及82例对照组的颈动脉分别进行检测,观察颈动脉后壁内-中膜厚度(IMT)、有无斑块形成.并根据是否伴有高血压及病程长短分组,将结果进行比较分析.结果:糖尿病各组IMT增厚共101例(81.5%).检出斑块96例(78.2%),对照组IMT增厚33例(40.2%),检出斑块26例(31.7%).两组比较有显著性差异(P无高血压组,结果有显著性差异(P5年者斑块检出率高于病程≤5年者,IMT厚度大于病程≤5年者厚度,结果有显著性差异(P<0.05).结论:2型糖尿病患者颈动脉病变以IMT增厚为主,其次是斑块形成.SonoCT技术可使颈部血管细微结构的分辨率提高,增加血管病变边界的可见度,QLAB测定颈动脉内膜平均厚度较最厚值更具优越性,对糖尿病血管病变的早期诊断及指导治疗具有重要价值.%Objective:To explore the value of intima-media thickness quantification technology and Sono CT in evaluating the vascular pathology of carotid artery in patients with type 2 diabetes mellitus. Methods: The carotid artery of 124 patients with type 2 diabetes mellitus and 82 healthy controls were detected respectively. The IMT of the the posterior wall of the carotid artery, and the presence of atherosclerotic plaque were observed. The patients were divided into DM1 group and DM2 group according to with or without hypertention, and the course of disease. Results: In DM1 with hypertention and DM2 without hypertention, the prevalence rates of carotid IMT are 81.5%, rates of carotid plaque are 78.2%, while in control group the data were 40.2% and 31.7%. There was significant difference between the two groups (P < 0. 05). The prevalence rates of carotid plaque of DM2 are higher than DMI, mean carotid IMT of DM2 which detected by QLAB are higher than that of DM1, with highly significant

  8. E-Tracking Technology for Evaluating Carotid Artery Elasticity in Active Smokers%血管回声跟踪技术定量评价吸烟者颈动脉弹性

    Institute of Scientific and Technical Information of China (English)

    梁永平; 马琳

    2011-01-01

    目的:探讨血管回声跟踪技术(ET)定量评价吸烟者颈动脉血管弹性的意义.方法:选取体检结果正常的男性吸烟者132例,非吸烟者49例(A组).按吸烟指数将吸烟者分为3组,B组(≤400支年/d)、C组(401~800支年/d)、D组(801~1 200支年/d).应用ET技术检测各组颈动脉内中膜厚度(IMT)、收缩期血管内径(Ds)和舒张期血管内径(Dd),并计算硬度指数(β)、压力应变弹性系数(Ep)、动脉顺应性(AC)及单点脉搏波传导速度(PWVβ).结果:对照组及各吸烟组间IMT、Ds及Dd差异均无统计学意义,4组β、Ep、AC及PWVβ差异有统计学意义(P<0.01),A组与B组比较差异无统计学意义,3个吸烟组中任意两组比较差异均有统计学意义(P< 0.05或P<0.01).β、Ep及PWVβ均随吸烟指数的增加而增高,而AC随吸烟指数的增加而减低.结论:ET技术能准确获取吸烟者颈动脉弹性参数,在血管发生形态学改变前检测出动脉硬化趋势.%Objective: To explore the value of E-tracking technology (ET) in evaluating carotid artery elasticity in active smokers. Methods: One hundred and thirty-two active smokers and 49 normal nonsmoking persons (group A) were enrolled in this study, and active smokers were divided into 3 groups by cigarette-smoking index (CSI=the number of cigarette-smoked each day × the year of cigarette smoking), including group B (CSI≤400), group C (CSI=401-800) and group D (CSI=801-1 200). ET was used to detect the intima media thickness (IMT), internal diameter of systolic (D.) and internal diameter of diastole (Dd). The values of stiffness parameters (B), pressure-strain elastic modulus (Ep), arterial compliance (AC) and pulse wave conducting velocity (PWVB) were calculated and analysed in 4 groups. Results: There were no statistical significances in age, body mass index (BMI), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PD), IMT, Ds, and Dd between group A

  9. Relationship of Elongated Styloid Process in Digital Panoramic Radiography with Carotid Intima Thickness and Carotid Atheroma in Doppler Ultrasonography in Osteoporotic Females

    Directory of Open Access Journals (Sweden)

    Shahram Hamedani

    2015-06-01

    Full Text Available Statement of the Problem: Cardiovascular disease and osteoporosis are major health dilemmas. Osteoporotic patients frequently display vascular calcification that consequently increases the cardiovascular morbidity and mortality. Purpose: This study aimed to investigate the relation of osteoporosis, vascular calcification (atheroma, intima-media thickness (IMT and elongated styloid process (ESP in a sample of osteoporotic and normal female individuals. Materials and Method: This study recruited 78 women who were assessed for bone mass density (BMD. Sample included individuals with normal BMD (n=13, 17 %, osteopenia (n=36, 46 %, and osteoporosis (n=29, 37%. The presence of atheroma and IMT was examined using color Doppler ultrasonography (CD-US. In addition, digital panoramic radiographs (PRs were obtained to assess ESP. Results: In this study, 55 subjects (70% with low BMD exhibited at least one side ESP. Femoral BMD decreased significantly in subjects with ESP (p= 0.03. Bilateral ESP was correlated with the presence of atheroma (p= 0.029. The CIMT was greater in patients with ESP, although the relation was not significant. Conclusion: The obtained data suggest referring the aged individuals with ESP for BMD assessment and individuals with low bone mass and ESP for more cardiovascular risk assessment.

  10. Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis

    Directory of Open Access Journals (Sweden)

    Chien Kuo-Liong

    2012-08-01

    Full Text Available Abstract Background The effects of baseline and changes in blood pressure and low density lipoprotein (LDL cholesterol on the carotid intima media thickness (IMT have not been well documented. Methods A total of 2572 adults (mean age 53.8 years, 54.6% women in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT. Results Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p Conclusions Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation.

  11. Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents

    Directory of Open Access Journals (Sweden)

    Larissa R. Silva

    2014-03-01

    Full Text Available Background: Increased carotid intima-media thickness (c-IMT is considered a marker of early-onset atherosclerosis and it has been found in obese children and adolescents, but the risk factors associated with this population remain to be elucidated. Objective : To compare and verify the relationship between c-IMT, metabolic profile, inflammatory markers, and cardiorespiratory fitness in obese and non-obese children and adolescents. Method : Thirty-five obese subjects (19 boys and 18 non-obese subjects (9 boys, aged 10-16 years, were included. Anthropometry, body composition, blood pressure, maximal oxygen consumption (VO2max, and basal metabolic rate were evaluated. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR, blood lipids, C-reactive protein (CRP, and adiponectin were assessed. c-IMT was measured by ultrasound. Results: The results showed that c-IMT, triglycerides, insulin, HOMA-IR, and CRP values were significantly higher in the obese group than in the non-obese group, and high-density lipoprotein cholesterol (HDL-c, adiponectin, and VO2max values were significantly lower in the obese group than in the non-obese group. The c-IMT was directly correlated with body weight, waist circumference, % body fat, and HOMA-IR and inversely correlated with % free fat mass, HDL-c, and VO2max. Conclusions : Our findings show that c-IMT correlates not only with body composition, lipids, insulin resistance, and inflammation but also with low VO2max values in children and adolescents.

  12. General principles of carotid Doppler ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Whal [Dept. of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2014-03-15

    Carotid Doppler ultrasonography is a popular tool for evaluating atherosclerosis of the carotid artery. Its two-dimensional gray scale can be used for measuring the intima-media thickness, which is very good biomarker for atherosclerosis and can aid in plaque characterization. The plaque morphology is related to the risk of stroke. The ulceration of plaque is also known as one of the strong predictors of future embolic event risk. Color Doppler ultrasonography and pulse Doppler ultrasonography have been used for detecting carotid artery stenosis. Doppler ultrasonography has unique physical properties. The operator should be familiar with the physics and other parameters of Doppler ultrasonography to perform optimal Doppler ultrasonography studies.

  13. 维持性血液透析患者颈动脉钙化相关因素分析%Correlation Factors with Carotid Artery Calcification in Maintenance Hemodialysis Patients

    Institute of Scientific and Technical Information of China (English)

    陈洪滔; 何永成; 曾爱莲; 栾韶东; 万启军; 陈海波

    2009-01-01

    Objective: To investigate prevalence and correlation factors of carotid calcification and in maintenance hemodialy-sis patients. Methods:The intima- media thickness (IMT) and calcification degree of bilateral carotid artery were detected by ultra-sonography in 35 maintenance hernodialysis (MHD) patients. Years on hernodialysis, systolic/pulse blood pressure, serum calcium/phosphorus and its product, serum lipid profile, C-reaction protein(CRP), intact- parathyroid hormone(i-PTH) were checked at the same time. Results: Carotid calcification was confirmed in 18 of 35 MHD patients (51.4%). 1MT( P< 0.01 ), years on hemodial-ysis, systolic/pulse blood pressure, serum calcium phosphorus product, CPR were significantly higher (P < 0.05) and serum albumin was significantly lower(P<0.05) in patients with carotid calcification than those in patients without carotid calcification. Conclu-sion: IMT, years on hemodialysis and serum calcium phosphorus product were main influential factors of carotid calcification 'in MIlD and systolic/pulse blood pressure, higher CRP level, lower serum albumin were closely correlated with carotid calcification. Carotid calcification was very prevalent in MHD patients.%目的:探讨慢性肾衰竭维持性血液透析(MHD)患者颈动脉钙化情况并分析相关因素.方法:对35例MHD患者应用彩色B型超声仪观测双侧颈动脉内膜-中膜厚度(IMT)及钙化情况,同时记录透析龄、收缩压、脉压差,抽血检测血钙、磷、血胆固醇、三酰甘油、白蛋白、C反应蛋白(CRP)、甲状旁腺素,并计算钙磷乘积.结果:35例终末期肾病(ESRD)患者18例(51.4%)存在颈动脉钙化.钙化组IMT值较无钙化组显著增高(P<0.01),透析龄、收缩压、脉压差、血磷、钙磷乘积、CRP较无钙化组明显增高(P<0.05),而钙化组血浆白蛋白较无钙化组显著降低(P<0.05).结论:IMT值、透析龄、血磷、钙磷乘积增高是颈动脉钙化的主要影响因素,收缩压、脉压差

  14. Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension

    Science.gov (United States)

    Sasagawa, Shota; Nishimura, Yuhei; Sawada, Hirofumi; Zhang, Erquan; Okabe, Shiko; Murakami, Soichiro; Ashikawa, Yoshifumi; Yuge, Mizuki; Kawaguchi, Koki; Kawase, Reiko; Mitani, Yoshihide; Maruyama, Kazuo; Tanaka, Toshio

    2016-01-01

    80 immunoreactivity in a rat PAHmodel and found increased expression in the hypertrophied media and adventitia of the pre-acinar pulmonary arteries (PAs) and in the thickened intima, media, and adventitia of the obstructed intra-acinar PAs. These results suggest that increased expression of CCDC80 may be involved in the pathogenesis of PAH, potentially by modulating the expression of endothelin-1 and COL1A1.

  15. Carotid intima-medial thickness measured on multiple ultrasound frames: evaluation of a DICOM-based software system

    Directory of Open Access Journals (Sweden)

    McQuillan Brendan M

    2007-09-01

    Full Text Available Abstract Background Carotid intima-media thickness (CIMT measured by B-mode ultrasonography is a marker of atherosclerosis and is commonly used as an outcome in intervention trials. We have developed DICOM-based software that measures CIMT rapidly on multiple end-diastolic image frames. The aims of this study were to compare the performance of our new software with older bitmap-based CIMT measurement software and to determine whether a ten-fold increase in the number of measurements used to calculate mean CIMT would improve reproducibility. Methods Two independent sonographers recorded replicate carotid scans in thirty volunteers and two blinded observers measured CIMT off-line using the new DICOM-based software and older bitmap-based software. A Bland-Altman plot was used to compare CIMT results from the two software programs and t-tests were used to compare analysis times. F-tests were used to compare the co-efficients of variation (CVs from a standard six-frame measurement protocol with CVs from a sixty-frame measurement protocol. Ordinary least products (OLP regression was used to test for sonographer and observer biases. Results The new DICOM-based software was much faster than older bitmap-based software (average measurement time for one scan 3.4 ± 0.6 minutes versus 8.4 ± 1.8 minutes, p Conclusion While the use of DICOM-based software significantly reduced analysis time, a ten-fold increase in the number of measurements used to calculate CIMT did not improve reproducibility. In addition, we found that observer biases caused differences in mean CIMT of a magnitude commonly reported as significant in intervention trials. Our results highlight the importance of good study design with concurrent controls and the need to ensure that no observer drift occurs between baseline and follow-up measurements when CIMT is used to monitor the effect of an intervention.

  16. Arterial Ageing

    OpenAIRE

    Lee, Seung-Jun; Park, Sung-Ha

    2013-01-01

    Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiabl...

  17. Maximal exercise capacity is related to cardiovascular structure in patients with longstanding hypertension. A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension

    DEFF Research Database (Denmark)

    Olsen, M H; Wachtell, K; Hermann, K L;

    2001-01-01

    compliance by echocardiography, minimal forearm vascular resistance (MFVR) by plethysmography, and intima media thickness and distensibility in the common carotid arteries by ultrasound. RESULTS: The patients did not achieve the maximal workload as predicted by age, gender and body composition (146...... unmedicated patients with essential hypertension and electrocardiographic left ventricular (LV) hypertrophy, we measured maximal workload and oxygen reserve by bicycle test, 24-h ambulatory blood pressure (BP), LV mass index by magnetic resonance imaging (LVMI(MRI), n = 31), LVMI(echo) and systemic vascular...

  18. Atherosclerosis occurs in patients undergoing maintenance hemodialysis%维持性血液透析患者的动脉粥样硬化★

    Institute of Scientific and Technical Information of China (English)

    吴道诩; 徐岩

    2013-01-01

    BACKGROUND:Atherosclerosis is a common complication in diabetic nephropathy and hemodialysis patients. The effect of hemodialysis duration and other relative factors on the atherosclerosis of patients with diabetic nephropathy needs to be further observed and explored. OBJECTIVE:To observe the atherosclerosis in the patients with different hemodialysis durations, then to evaluate the effect of hemodialysis duration and other relative factors on atherosclerosis of patients with diabetic nephropathy. METHODS:The intima-media thickness of the carotid artery in the diabetic nephropathy hemodialysis group, non-diabetic nephropathy hemodialysis group and end-stage renal disease non-hemodialysis group was detected with high-frequency ultrasonic testing, and the healthy volunteers were as the normal control group. The relationship between the intima-media thickness of the carotid artery in the hemodialysis patients and hemodialysis duration was analyzed, and the changes of insulin resistance in each group were compared. RESULTS AND CONCLUSION:Compared with the normal control group