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Sample records for arteriosclerosis obliterans

  1. [Ozone therapy in the advanced stages of arteriosclerosis obliterans].

    Science.gov (United States)

    Romero Valdés, A; Menéndez Cepero, S; Gómez Moraleda, M; Ley Pozo, J

    1993-01-01

    Fifteen patients with atherosclerosis obliterans at the lower limbs, no candidates to revascularizing surgery were submitted to ozone therapy. An improvement statistically significant was noticed in the treatment groups since amputation ratio decreased (26.7%) and the need of pain's surgery procedures (13.3%) in comparison with the control group (46.7 and 26.7% respectively). Ozone therapy is considered as a good way in the management of the atherosclerosis with obliteration in late period.

  2. Effect of Ligustrazine Injection on Vascular Endothelial Cell of The Patients with Arteriosclerosis Obliterans

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: To study the effect of ligustrazine injection (LI) on vascular endothelial cell of the patients with arteriosclerosis obliterans (ASO) and explore the new pathway of investigating effective vascular protective agents in Chinese medicinal herbs. Methods: Forty-six patients with ASO in the LI group treated by LI were observed, their circulating endothelial cells (CEC) were detected quantitatively before and after treatment. The results were compared with the CEC of 53 cases of healthy persons (control group) in the same period. Results: In the LI group, the immediate cure rate was 45.7% (21 cases), markedly effective rate 36.9% (17 cases) and the effective rate 17.4% (8 cases). The CEC of patients before treatment was 4.39±1.76/0.9μl, which was significantly higher than that of the healthy persons (1.53±0.42/0.9μl). It could be reduced after treatment, along with the improvement of symptoms and signs, to 2.43±0.87/0.9μl, P<0.01. Conclusion: LI in treating ASO not only displays extraordinary effect, but also has good effect in curing the damage of endothelial cells.

  3. The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population

    Directory of Open Access Journals (Sweden)

    Kun Zhang

    2017-01-01

    Full Text Available Background and aims: Cholesterol crystals have been shown to cause inflammation. As a response to cholesterol crystal accumulation, the NLRP3 inflammasome is activated to produce IL-1β which eventually leads to atherosclerotic lesions. As a part of innate immunity, CARD8 is involved in the modulation of above mentioned inflammatory activities. The primary objective of this study was to investigate the association between polymorphism of CARD8 rs2043211 and susceptibility to arteriosclerosis obliterans (ASO in Chinese Han male population. Methods: 758 male arteriosclerosis obliterans patients and 793 male controls were genotyped for rs2043211 with the TaqMan allele assays. Fasting blood-glucose (FBG, total cholesterol (TC, triglycerides (TG, urea nitrogen, creatinine, Serum uric acid, high density lipoprotein, low density lipoprotein, ALT, AST, and IL-1β in the blood were detected for all subjects. Clinical data were recorded to analyze the genotype-phenotype. Independent samples t-test was used to perform the comparisons between two groups. Odds ratios (ORs with 95% confidence intervals (CIs were calculated to measure the strength of relationship in the genotype distribution and allele frequencies between patients and controls. The analysis of variance was used for a genotype-phenotype analysis of the ASO patients. Results: The genotypic and allelic frequencies in the ASO group were significantly different from that in the control group (P = 0.014 by genotype, P = 0.003 by allele. Those carrying the genotype TT had a higher risk for ASO than those carrying the genotype AA (OR = 1.494, 95%CI1.131-1.974, P = 0.005.The difference was also significant after the adjustment for the history of smoking, TC, LDL, fasting blood glucose, systolic blood pressure and BMI(OR = 1.525, 95%CI1.158-2.009, P = 0.003. Conclusion: Our finding suggests that the polymorphism of CARD8 rs2043211 is probably associated with the development of ASO in Chinese Han male

  4. Usefulness of preoperative coronary angiography and brain computed tomography in cases of coronary artery disease and cerebrovascular disease undergoing revascularization for arteriosclerosis obliterans

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    Sakurada, Tall; Shibata, Yoshiki [Southern Tohoku Fukushima Hospital (Japan)

    2003-05-01

    Coronary angiography and brain computed tomography were preoperatively performed to evaluate the clinical condition of coronary artery disease and cerebrovascular disease in 101 patients (mean age, 68.4 years) with revascularization for arteriosclerosis obliterans. Eighty patients had hypertension, 12 had diabetes, and 26 had hyperlipidemia. Seventy-one patients (70.3%) had coronary stenosis. Significant stenoses in major coronary artery branches were confirmed in 35 patients, including 13 patients with old myocardial infarction. Coronary artery bypass grafting and percutaneous coronary angioplasty were performed in 2 and 7 patients with critical stenosis, respectively. Of 57 patients, who underwent brain computed tomography, abnormalities were found in 52 patients (91.2%), including cortical infarction in 9, lacunar infarction in 35, and leukoaraiosis in 27 patients. During the follow-up period 13 patients died (including 3 cases of myocardial infarction and 3 cases of stroke). Actuarial survival rate at 5 years was 80.4%. The influence of ischemic heart disease and cerebrovascular disease on early and late mortality after surgical reconstruction for peripheral occlusive vascular disease is significant. Using visual diagnostic techniques, such as coronary angiography and brain computed tomography, long term survivor should be closely observed for multiple arteriosclerotic vascular diseases. (author)

  5. Evaluation of percutaneous transluminal angioplasty for treatment of infrapopliteal arteriosclerosis obliterans%经皮腔内血管成形术治疗膝下动脉粥样硬化闭塞症的评价

    Institute of Scientific and Technical Information of China (English)

    张玉超; 黄英; 李维敏; 陆信武; 黄新天; 陆民; 蒋米尔

    2012-01-01

    Objective To assess the therapeutic effect of percutaneous transluminal angioplasty ( PTA )on the treatment of infrapopliteal arteriosclerosis obliterans( ASOs ). Methods From Jan. 2007 to Jun. 2011, clinical data of patients with infrapopliteal ASO undergoing PTA at our department were retrospectively reviewed. Results Infrapopliteal PTA was performed on 138 lower limbs for 138 patients( mean age,77. 31 ±7. 52 year - old ). The mean diameter of balloon catheters used for infrapopliteal arteries was 2. 8 mm( 2 mm ~4 mm ), with the mean length of 110. 6 mm( 40 mm ~ 170 mm ). There were no severe complications occurring intraoperatively or postoperatively. Early results showed that all patients had significant improvement in ischemic symptoms( 100% ), and no patients had limb loss. During a mean follow -up of 24. 1 months( 4 ~ 58 months ), the rate of improvement in ischemic symptoms for treated limbs was 78. 4% and the limb salvage rate was 93. 9% at 2 years. Conclusion Minimal invasive PTA for the treatment of infrapopliteal ASO is safe and effective for improving ischemic symptoms of lower limbs and limb salvage.%目的 评价经皮腔内血管成形术(percutaneous transluminal angioplasty,PTA)治疗膝下动脉粥样硬化闭塞症(arteriosclerosis obliterans,ASO)的疗效.方法 回顾性研究2007年1月至2011年6月我科收治的累及膝下动脉ASO并行PTA治疗的患者的临床资料.结果 138例患者,平均年龄(77.31±7.52)岁,治疗膝下动脉所用球囊平均直径 2.8mm(2~4mm),平均长度110.6mm(40~170mm),术中及术后无严重并发症.术后早期治疗肢体临床症状明显改善率为100%,无截肢患者.平均随访24.1个月(4~58个月),治疗肢体术后2年临床症状明显改善率78.4%,救肢率93.9%.结论 PTA治疗膝下动脉ASO可有效改善临床缺血症状并提高救肢率.

  6. Efficacy of erigeron breviscapus combined with alprostadil in treating senile diabetic arteriosclerosis obliterans of the lower extremities: A clinical analysis of 25 cases%灯盏细辛联合前列地尔治疗老年糖尿病下肢动脉硬化闭塞症25例疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈燕霞

    2012-01-01

    Objective To explore the clinical efficacy of erigeron breviscapus combined with alprostadil in treating senile diabetic arteriosclerosis obliterans of lower extremities. Methods Fifty patients with senile diabetes complicated with arteriosclerosis obliterans of lower extremities were randomly divided into two groups. The treatment group received lamps asarum injection combined with alprostadil. The control group (n = 25) received alprostadil treatment. The course of treatment was 2 weeks. Results The total efficacy rate of the treatment group was 96% , and the control group was 76% . The two groups had statistical difference (P<0. 05). The treatment group was significantly better than the control group. Conclusion Erigeron breviscapus combined with alprostadil in treatment of elderly patients with diabetic arteriosclerosis obliterans of lower extremities has better curative effect.%目的 针对灯盏细辛注射液联合前列地尔治疗老年糖尿病下肢动脉硬化闭塞症的疗效观察.方法 50例老年糖尿病合并下肢动脉硬化闭塞症患者随机分为2组,治疗组采用灯盏细辛注射液联合前列地尔,对照组25例采用前列地尔治疗,疗程2周.结果 治疗组总有效率96%,对照组总有效率76%,两组比较有统计学差异(P<0.05),治疗组明显优于对照组.结论 灯盏细辛联合前列地尔治疗老年糖尿病下肢动脉硬化闭塞症有较好的疗效.

  7. 下肢动脉硬化性闭塞症介入治疗的回顾性分析%Interventional Revascularization of the Lower Limbs Arteriosclerosis Obliterans:A Retrospective Study

    Institute of Scientific and Technical Information of China (English)

    吴正阳; 鲁海涛; 朱悦琦; 谭华桥; 赵俊功

    2012-01-01

    目的 回顾性分析下肢动脉硬化性闭塞症(arteriosclerosis obliterans,ASO)介入治疗的临床疗效和通畅率.方法 从2009年10月到2011年7月,32例(39条下肢)下肢ASO患者在上海交通大学附属第六人民医院行介入治疗.回顾性分析32例ASO患者的血管造影图像,根据病变长度和程度分级.对手术成功患者随访,随访期3 ~16个月,平均随访期(8.7±1.9)个月.随访期内每3个月进行一次下肢MRA或CTA检查,并搜集相关临床资料.结果 技术成功率93%,踝肱指数(ankle-brachial index,ABI)从术前的0.47±0.11提高至术后的0.68±0.02,在随访期末20例取得了稳定疗效,总的通畅率为77%,保肢率为97%.结论 介入治疗ASO安全可行,取得了良好的临床效果及通畅率,其长期疗效尚需进一步观察.%Objective To retrospectively evaluated the clinical efficacy of interventional revascularization for lower limbs arteriosclerosis obliterans (ASO). Methods From Oct 2009 to July 2011, 32 patients (39 limbs) with lower limbs ASO performed interventional revascularization in our center. Angiography was retrospectively analyzed, and every lesion categorized and classified according to its length and severity. The mean follow up period was 3 - 162 months, mean 8.7 ± 1.9 months. Lower limb magnetic resonance angiography (MRA) or computed tomography angiography (CTA) was performed every 3 months during follow-up. The clinical data were collected. Results 93% technical success rate was obtained. Ankle-brachial index (ABI) improved from 0. 47 ±0. 11 to 0. 68 ± 0. 02. At the end of follow up, 20 patients maintained a stable outcome, gained a 77% patency rate and 97% limb salvage rate. Conclusion Interventional revascularization is safe and feasible in the treatment of lower limbs ASO. With encouraging clinical outcome and patency rate, further research is warranted to evaluate long-term outcome.

  8. MiR-142-3p attenuates the migration of CD4⁺ T cells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans.

    Science.gov (United States)

    Liu, Jiawei; Li, Wen; Wang, Siwen; Wu, Yidan; Li, Zilun; Wang, Wenjian; Liu, Ruiming; Ou, Jingsong; Zhang, Chunxiang; Wang, Shenming

    2014-01-01

    The migration of CD4+ T cells plays an important role in arteriosclerosis obliterans (ASO). However, the molecular mechanisms involved in CD4+ T cell migration are still unclear. The current study is aimed to determine the expression change of miR-142-3p in CD4+ T cells from patients with ASO and investigate its role in CD4+ T cell migration as well the potential mechanisms involved. We identified by qRT-PCR and in situ hybridization that the expression of miR-142-3p in CD4+ T cells was significantly down-regulated in patients with ASO. Chemokine (C-X-C motif) ligand 12 (CXCL12), a common inflammatory chemokine under the ASO condition, was able to down-regulate the expression of miR-142-3p in cultured CD4+ T cells. Up-regulation of miR-142-3p by lentivirus-mediated gene transfer had a strong inhibitory effect on CD4+ T cell migration both in cultured human cells in vitro and in mouse aortas and spleens in vivo. RAC1 and ROCK2 were identified to be the direct target genes in human CD4+ T cells, which are further confirmed by dual luciferase assay. MiR-142-3p had strong regulatory effects on actin cytoskeleton as shown by the actin staining in CD4+ T cells. The results suggest that the expression of miR-142-3p is down-regulated in CD4+ T cells from patients with ASO. The down-regulation of miR-142-3p could increase the migration of CD4+ T cells to the vascular walls by regulation of actin cytoskeleton via its target genes, RAC1 and ROCK2.

  9. MiR-142-3p attenuates the migration of CD4⁺ T cells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans.

    Directory of Open Access Journals (Sweden)

    Jiawei Liu

    Full Text Available The migration of CD4+ T cells plays an important role in arteriosclerosis obliterans (ASO. However, the molecular mechanisms involved in CD4+ T cell migration are still unclear. The current study is aimed to determine the expression change of miR-142-3p in CD4+ T cells from patients with ASO and investigate its role in CD4+ T cell migration as well the potential mechanisms involved. We identified by qRT-PCR and in situ hybridization that the expression of miR-142-3p in CD4+ T cells was significantly down-regulated in patients with ASO. Chemokine (C-X-C motif ligand 12 (CXCL12, a common inflammatory chemokine under the ASO condition, was able to down-regulate the expression of miR-142-3p in cultured CD4+ T cells. Up-regulation of miR-142-3p by lentivirus-mediated gene transfer had a strong inhibitory effect on CD4+ T cell migration both in cultured human cells in vitro and in mouse aortas and spleens in vivo. RAC1 and ROCK2 were identified to be the direct target genes in human CD4+ T cells, which are further confirmed by dual luciferase assay. MiR-142-3p had strong regulatory effects on actin cytoskeleton as shown by the actin staining in CD4+ T cells. The results suggest that the expression of miR-142-3p is down-regulated in CD4+ T cells from patients with ASO. The down-regulation of miR-142-3p could increase the migration of CD4+ T cells to the vascular walls by regulation of actin cytoskeleton via its target genes, RAC1 and ROCK2.

  10. 真腔内技术治疗股腘动脉硬化闭塞症55例%True lumen technique in the application of endovascular treatment for femoropopliteal arteriosclerosis obliterans of the lower extremities

    Institute of Scientific and Technical Information of China (English)

    于小滨; 李晓强; 孟庆友; 钱爱民; 桑宏飞; 戎建杰; 朱礼炜; 雷锋锐

    2015-01-01

    Objective To evaluate the clinical effect of the application of true lumen technology in endovascular treatment of femoropopliteal arteriosclerosis obliterans of the lower extremity.Methods From April 2009 to April 2013, 60 limbs in 55 patients of femoropopliteal arteriosclerosis obliterans received endovascular treatment using the true lumen technique.The average length of occlusion artery before operation was(13 ±3)cm, and the average ABI(ankle brachial index)was 0.47 ± 0.06.With the help of Roadmap, the vertical artery catheter and small diameter guide wire were usually applied during the operation,and we used the "rotation" technique to make sure guide wire goes through the occlusive segment in the true lumen.After the accomplishment of the guide wire, we performed angioplasty and atherectomy.Patients were followed up regularly by ultrasound or CTA.Results The technical success rate was 91.7%.We performed PTA in 9 cases, PTA and stent placement in 41 cases and 5 cases received endovascular atherectomy.The average number of stent placed during operation was 1.6 ± 0.6 and average length of stent was(8.2 ± 1.4)cm.The average ABI 3 days after operation was 0.73 ±0.10 (P <0.01).13 cases developed complications and amputation was done in 1 case.48 legs in 46 patients were followed up for the average period of (24 ± 11) months.The average ABI of 6 months, 12 months and 24 months after operation were 0.72 ±0.15, 0.67 ±0.13 and 0.63 ±0.19 respectively.The primary patency rate, assistant patency rate and secondary patency rate in 12 months and 24 months were 73.0%, 81.1%, 89.2% and 63.6%, 68.2% , 72.7% respectively.Conclusions The high successful rate and satisfactory early result could be obtained through the application of true lumen technology in the endovascular treatment of femoropopliteal atherosclerosis obliterans.%目的 总结真腔内通过闭塞段技术治疗下肢股腘动脉硬化闭塞症的临床疗效.方法 2009年3月至2013

  11. Efficacy of profound femoral artery revascularization on TASC type D arteriosclerosis obliterans%股深动脉优势供血治疗TASC D型动脉硬化下肢缺血的疗效分析

    Institute of Scientific and Technical Information of China (English)

    田轩; 刘建龙; 贾伟; 蒋鹏; 程志远; 张蕴鑫; 田晨阳

    2016-01-01

    目的:探讨髂动脉通畅的泛大西洋协作组织共识(TASC) D型动脉硬化下肢缺血的治疗方式,比较股浅动脉支架植入术与股深动脉成形术的疗效。方法回顾性地分析2007年1月至2010年12月北京积水潭医院血管外科收治的32例TASC D型下肢缺血患者临床资料,随机分为股浅动脉治疗组(行股浅动脉球囊扩张+支架植入术)16例和股深动脉治疗组16例,并进行对照分析。通过对比手术前后踝肱指数(ABI)、手术后3年截肢率及症状改善情况评价两种方法的疗效。结果两组患者术后ABI均明显高于术前(P<0.05);且股浅动脉治疗组术后ABI高于股深动脉治疗组(P<0.05)。两组3年后跛行距离<200米和行截肢手术患者比较,差异均无统计学意义(P>0.05)。结论髂动脉通畅的TASC D型动脉硬化下肢缺血患者,无论腔内股浅动脉支架植入术还是股深动脉成形术均可改善患者症状,增加肢体血供;股浅动脉支架植入对患者近期远端肢体血供改善优于股深动脉成形术。%ObjectiveTo compare the efficacy of revascularization of profoundfemoral arteryversus superficial femoral artery on TASC type D arteriosclerosis obliterans.MethodsClinical data of45 cases of TASC type D arteriosclerosis obliteransadmitted in our hospital from January 2007 to December 2010 were collected andretrospectively analyzed.Sixteen patients received endovascular balloon dilation combined with stent implantation into superficial femoral artery, and another 16 patients underwentsimilarrevascularizationbut into profoundfemoral artery. The efficacy variables including ankle-brachialindex(ABI), amputation rate in 3 yearsafter surgery, and the relief of symptoms were used to evaluate the efficacy of the 2 approachesinthe32cases.ResultsRevascularizationresulted in significant increases in ABI in the 2 groups (P0.05).ConclusionForthe patients with

  12. Clinical observations on aerodynamic wave plus Alprostadil for the treatment of diabetes lower limb arteriosclerosis obliterans%空气动力波联合前列地尔治疗糖尿病下肢动脉硬化闭塞症的临床观察

    Institute of Scientific and Technical Information of China (English)

    余红梅; 胡清; 曾玉琴; 汪晓芬; 王娜娜; 龚丽; 李雪锋

    2014-01-01

    目的:观察空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症的临床疗效,并探讨其治疗机制。方法将符合纳入标准的54例患者随机分为2组,治疗组30例采用空气动力波联合前列地尔治疗,对照组28例仅采用前列地尔治疗,治疗2个疗程后评定2组临床疗效,并观察治疗前后下肢动脉血管内径、血流量及踝肱指数的变化情况。结果治疗2个疗程后,治疗组疗效优于对照组(P<0.05);治疗组下肢血管内径、血流量、踝肱指数改善程度均优于对照组(P均<0.05)。结论空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症安全有效,其疗效优于单一前列地尔治疗。%Objective It is to observe the clinical efficacy of aerodynamic wave plus Alprostadil on diabetic lower limb ar -teriosclerosis obliterans ,and to explore its mechanism .Methods 54 patients with diabetic lower limb arteriosclerosis obliterans were randomly allocated to treatment groups of 34 cases and control groups of 20 cases, the treatment group were treated with Aerodynamic wave plus Alprostadil , the control group were treated with Alprostadil only .After two treatment courses , the clin-ical curative effects of both groups were assessed , and the changes of blood vessel diameter of lower extremity artery , blood flow and ankle brachial index ( ABI) before and after treatment were observed .Results After two treatment courses , the cura-tive effect of treatment group was better than that of control group (P<0.05), and the improvements of blood vessel diameter of lower extremity artery, blood flow and ABI were also better than those of control group (P<0.05).Conclusion Aerody-namic wave plus Alprostadil is effective and safe in the treatment for diabetic lower limb arteriosclerosis obliterans .Its effect is superior to that of treatment with Alprostadil only .

  13. Arteriosclerosis Detection

    Science.gov (United States)

    1976-01-01

    The Veterans Administration Hospital used computer image-processing techniques to detect arteriosclerosis. Originally developed by Goddard Space Flight Center engineers to enhance spacecraft pictures, this device replaced the previous testing for this disease which was extremely painful and time consuming. With this instrument, computer detected edges are shown along with an estimate of location of pre-arteriosclerosis vessel wall. The difference between the two represents the relative amount of disease in the blood vessel. Instrumentation will be expanded again in 1976 to analyze the coronary arteries and the blood vessels of the retina.

  14. 腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的临床诊治%Clinical treatment of the intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans

    Institute of Scientific and Technical Information of China (English)

    倪东馗; 吴义生; 庞小建; 李立军

    2010-01-01

    Objective To explore the principle of diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans. Method Eighteen cases of patients with intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans, using MRI and MRA, to determine the main reason due to of disease, to take the treatment for the cause. Results The patients were followed up for 7 to 24 months, average (16.0 ± 4.7) months. Assessed according to the modified MacNab criteria of clinical efficacy, excellent in 7 cases, good in 8 cases, general in 3 cases,satisfactory rate was 83.3%(15/18). Intermittent claudication were improved with all patients, walking distance of more than 1000 meters, relief rate was 100%. Postoperative ankle brachial score(0.90±0.54 ) was obviously increased compared with preoperative average(0.58±0.36), there was significant statistical difference(P<0.01). All cases were not amputee due to circulation disturbance. Conclusion The diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans,it is necessary to collect a history of serious and careful investigation,combined with imaging, can accurately determine the responsibility of lesions, target to give the appropriate treatment, can get a good effect%目的 探讨腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的诊治原则.方法 对18例患有腰椎疾病同时合并下肢动脉闭塞症的患者,利用MRI和MRA检查判定所致患者疾病的主要病因,采取针对病因的适宜治疗.结果 本组病例全部获得随访,随访时间7~24(16.0±4.7)个月.按改良MacNab标准评定临床疗效,优7例,良8例,可3例,优良率为83.3%(15/18).全部病例间歇性跛行明显改善,行走距离超过1000m,改善率100%.术后踝肱指数(ABI)0.90±0.54,较术前(0.58±0.36)明显增

  15. Study on Feasibility of Primary in Situ Vein Graft Arterialization Method in Treatment of Vasculitis and Arteriosclerosis Obliterans%大隐静脉原位动脉化修复脉管炎及动脉硬化闭塞症的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    蔡培强; 张广平; 李伟; 杨海澔; 邵玉凯

    2016-01-01

    Objective To explore the clinical application feasibility of primary in situ vein graft arterialization method in treatment of vasculitis and arteriosclerosis obliterans. Methods 56 cases of patients with vasculitis(61 affected limbs) and 60 cases of patients with arteriosclerosis obliterans (81 affected limbs) treated with venous valve removal or destruction and pri-mary in situ vein graft arterialization therapy in the department of orthopaedics from June 2011 to December 2014 were col-lected, and the walking, ischemic state of the affected limbs, pains, skin and other conditions of the postoperative patients were observed. Results The ischemic state of the affected limbs after operation of 142 cases was obviously improved, the se-vere rest pain of 26 cases was obviously relieved, the venous pulse of all patients was good, acra circulation was obviously improved, skin temperature was elevated compared with that before, the color of the affected limb endings after operation of 67 cases was from violaceous color to dark red, and the skin temperature returned to normal, after 6-month to 24-month of follow-up, the ischemia symptoms of the affected limbs totally disappeared, toe gangrenosum desquamated, stump was to-tally cured and ankle great saphenous vein touched pulse. Conclusion The effect of venous valve removal or destruction and primary in situ vein graft arterialization method in treatment of vasculitis and arteriosclerosis obliterans is good, which is worth promotion.%目的:探索原位一期静脉动脉化方式治疗脉管炎及动脉硬化闭塞症的临床应用可行性。方法方便收集2011年6月—2014年12月该院采用静脉瓣膜切除或破坏、原位一期静脉动脉化治疗的56例(61条患肢)脉管炎患者及60例(81条患肢)动脉硬化闭塞症,观察术后患者行走和患肢缺血状态、疼痛、皮肤等情况。结果142条患肢术后患肢缺血症状明显改善,26例剧烈静息痛明显缓

  16. 前列地尔联合益气活血化痰通络汤治疗下肢动脉硬化闭塞症的临床观察%Clinical observation of alprostadil combined with Yiqi Huoxue Huatan Tongluo Decoction in treating arteriosclerosis obliterans

    Institute of Scientific and Technical Information of China (English)

    龚伟强; 徐小平

    2015-01-01

    目的:观察前列地尔联合益气活血化痰通络汤治疗下肢动脉硬化闭塞症的临床疗效。方法将60例下肢动脉硬化闭塞症门诊及住院患者按照随机数字表法随机分为治疗组与对照组,每组各30例,将口服肠溶阿司匹林的实验组设为对照组,静脉输注前列地尔,治疗组则是在对照组的基础上加用化痰通络汤,疗程为4周。观察2组患者观察患者的临床症状、血管功能[踝肱指数( ankle-brachial index,ABI)]、低密度脂蛋白胆固醇( low density lipoprotein-cholesterol,LDL-C)、血清总胆固醇( total cholesterol, TC),血液流变学指标包括全血粘度、纤维原蛋白、肝肾功能及不良反应。结果治疗组总有效率为93.33%优于对照组的73.33%( P<0.05),治疗组踝肱指数( ABI)改善优于对照组,治疗组TC、LDL-C、高切全血粘度、低切全血粘度、纤维原蛋白改善均优于对照组(均P<0.05)。结论活血化痰通络方联合前列地尔治疗下肢动脉硬化闭塞症疗效优于单纯前列地尔治疗。%Objective To observe the clinical effect of alprostadil combined with Yiqi Huoxue Huatan Tongluo Decoction in treating arteriosclerosis obliterans.Methods 60 cases of lower extremity arteriosclerosis occlusion disease outpatient and hospitalized patients were randomly divided into treatment group and control group according to the random number table method, each group were 30, the oral administration of enteric coated aspirin experimental group is set to control group intravenous injection of alprostadil treatment for 4 weeks, the treatment group was treated with Huatan Tongluo Decoction on the basis of the control group.The clinical symptoms, blood vessel function (ABI),low density lipoprotein-cholesterol (LDL-C), total cholesterol( TC) were observed in the two groups of patients, and blood rheology indexes included whole blood viscosity, fibrinogen

  17. 闭塞性动脉硬化症患者肢端汗出速率、温度变化观察%Observation of sweating rate and temperature variation in arteriosclerosis obliterans patients

    Institute of Scientific and Technical Information of China (English)

    王雁南; 张启明; 杨建业; 刘中华

    2013-01-01

    Objective To investigate the evaluative meaning of the traditional Chinese medicine (TCM)sweat detector and temperature detector to atheriosclerosis obliterans (ASO).Methods 68 limb plantar of ASO patients and 20 left plantar of healthy subjects were tested by TCM sweat detector and temperature detector to observe the differences of sweating rate and temperature between the two groups.Results ①Sweating rate and temperature of ASO patients' limb plantar showed different graphic morphology from that of healthy control group.The sweating rate of patients was worse than that of healthy subjects in responding to external stimuli.②ASO patients'limb plantar baseline values of the sweating rate and temperature were lower than that of healthy subjects,and the result was statistical significant (P<0.01).Conclusion Data obtained from TCM sweat detector and temperature detector can be used to distinguish ASO patients from healthy people.%目的 研究中医汗出检测仪和体表温度检测仪对下肢动脉硬化闭塞症(ASO)的评价意义.方法 选取68例ASO患者和20例健康人,应用中医汗出检测仪和体表温度检测仪,分别检测患者患肢足底和健康人左侧足底的汗出速率、温度,比较2组汗出速率和温度的不同.结果 ASO患者肢端汗出速率和温度均表现出不同于健康对照组的图形形态,患者的肢端汗出速率对外界刺激的反应较正常人差;ASO患者的肢端汗出速率和温度的基线值均低于健康对照组,其差异具有统计学意义(P<0.01).结论 中医汗出检测仪和体表温度检测仪所测数据可用于区分ASO患者与健康人群.

  18. Clinical observation of femoral artery pressure perfusion of Shuxuetong injection on the treatment of phase Ⅱlower limb arteriosclerosis obliterans%疏血通注射液股动脉加压灌注治疗Ⅱ期下肢动脉硬化闭塞症60例临床观察

    Institute of Scientific and Technical Information of China (English)

    姜淑凤; 艾发元; 苗志勃; 王丽娟; 贾岩

    2012-01-01

    目的 观察疏血通注射液股动脉加压灌注对Ⅱ期下肢动脉硬化闭塞症的影响.方法 将120例Ⅱ期下肢动脉硬化闭塞症患者随机分为2组,治疗组60例采用疏血通注射液股动脉加压灌注治疗,对照组60例采用疏血通注射液静脉滴注治疗.2组均20d为1个疗程,共治疗1个疗程.观察2组治疗前后血液流变学指标及纤维蛋白原定量变化情况,检测患肢治疗前后血流束宽度及血流频谱峰值,统计临床疗效,评价安全性.结果 治疗组总有效率95.0%,对照组总有效率83.3%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.2组治疗后血液流变学指标、纤维蛋白原定量、血流束宽度及血流频谱峰值与本组治疗前比较均明显改善(P<0.05,P<0.01),且治疗组全血黏度(低切)及血浆黏度,股浅动脉、足背动脉、胫后动脉的血流束宽度及股浅动脉、腘动脉、胫前动脉的血流频谱峰值改善均优于对照组(P<0.05).2组均无明显不良反应.结论 采用股动脉加压灌注疏血通注射液治疗Ⅱ期下肢动脉硬化闭塞症安全、有效,值得临床推广应用.%Objective To the effect of femoral artery pressure perfusion of Shuxuetong injection on the treatment of phase II lower limb arteriosclerosis obliterans. Methods 120 patients with phase II lower limb arteriosclerosis obliterate were randomly divided into two groups. 60 cases in treatment group were treated by femoral artery pressure perfusion of Shuxuetong injection. 60 cases in control group were treated by intravenous infusion of Shuxuetong injection. The therapeutic course was 20 days in two groups. The changes of hemorheology index and fibrinogen before and after treatment were observed in the two groups. Flow beam width and peak flow spectrum before and after treatment were detected. Results The total effective rate in treatment group (95.0% ) was superior to that in control group (83.3% , P<0

  19. Preliminary assessment based on Delphi method on the arteriosclerosis obliterans syndrome differentiation basis importance%基于德尔菲法对下肢动脉硬化闭塞症辨证依据重要性评估探讨

    Institute of Scientific and Technical Information of China (English)

    张凡帆; 庞鹤; 高颖

    2012-01-01

    Objective: Through the Delphi expert consultation method, assess the importance of syndrome differentiation basis in arteriosclerosis obliterans, contribute the foundation for the standardization research of syndrome. Methods: sent questionnaires to 30 national experts, through analyzing the result of descriptive statistics, factor analysis, Kendall weighting coefficients, investgated and assessed the importance of syndrome differentiation basis about the local symptoms, systemic symptoms, tongue manifestation and pulse condition in arteriosclerosis obliteration. Results: local symptoms got the highest score in expert concentration degree, coordination degree and weight coefficient, which should be as the main syndrome in syndrome differentiation, the contribution of tongue manifestation was second. Pulse and systemic symptoms got the lowest scores in expert concentration, coordination degree and the weight coefficient, so how to grasp and application those symptoms in actual clinical syndrome differentiation should still need further study. Conclusion: This study displayed that the experts authority degree, concentration degree were both pretty good, but the experts didn't get the uniform conclusion about the importance of locaf symptoms, systemic symptoms, tongue manifestation and pulse in syndrome differentiation, we should continue summarizing and research in future clinical work.%目的:通过德尔菲专家咨询法,探讨下肢动脉硬化闭塞症辨证依据的重要性,为证候规范化研究打下基础.方法:向全国30名专家发出调查问卷,通过描述统计、Kendall系数分析、权重系数计算,对局部症状、全身其他症状、舌象、脉象作为下肢动脉硬化闭塞症辨证依据的重要性进行分析研究.结果:局部症状作为专家集中程度最大、协调程度最大、权重系数最大的一组指标在辨证中应作为主证,舌象的贡献度次之.脉象和全身症状专家集中程度小,协调程度小,

  20. [Arteriosclerosis obliterans. Treatment with angiotensin-converting enzyme inhibitors].

    Science.gov (United States)

    Orea, A; Valdés, R; Niebla, L; Rivas, R; Camacho, B

    1990-01-01

    We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor. We studied 22 patients: all of them with hypertension and/or skin ulcerations, dropping out those who had venous. They were evaluated periodically, clinically and with photoelectric plethysmography of lower extremities. To interpret the traces we designed an ideogram which gathered the plethysmographic behavior before and after the treatment. Nearly 80% showed considerable improvement in pain, functional capacity and plethysmographic traces patterns. healing of the ulcerations was achieved in all case. We propose some hypothesis to explain the good effect that we have observed.

  1. [Arteriosclerosis obliterans and ozone therapy. Its administration by different routes].

    Science.gov (United States)

    Romero Valdés, A; Blanco González, R; Menéndez Cepero, S; Gómez Moraleda, M; Ley Pozo, J

    1993-01-01

    We report 72 non-diabetic patients with obliterant atherosclerosis, stadium II, (intermittent claudication). The medium age of these patients was 62 +/- 4.5 years old. They were randomly included into four groups. Three were treated with Ozone: one of them by endovenous way, other intramuscular way, and the last one by rectal way; meanwhile, in the fourth group the patients were submitted to conventional medical treatment (control group). In the three ozone-groups there weren't differences when they were compared between then. But there was a significant improvement in comparison with the control group. The claudication distance in the treadmill increased to the 2.5 km/hour. Ankle/arm pressure rates hadn't significant differences, this corroborates the ozone action on the microcirculation. The least uncomfortable, the more harmless and the more economic way was the rectal way.

  2. [Helicobacter pylori and Arteriosclerosis].

    Science.gov (United States)

    Matsui, Teruaki

    2011-03-01

    Helicobacter pylori (H. pylori) infection-related diseases are known to include gastritis, gastric and duodenal ulcer, gastric cancer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, iron-deficient anemia, urticaria, reflux esophagitis, and some lifestyle-related diseases. It is indicated that homocysteine involved with arteriosclerosis induces lifestyle-related diseases. Homocysteine is decomposed to methionine and cysteine (useful substances) in the liver, through the involvement of vitamin B₁₂ (VB₁₂) and folic acid. However, deficiency of VB₁₂ and folic acid induces an increase in unmetabolized homocysteine stimulating active oxygen and promoting arteriosclerosis. VB₁₂ and folic acid are activated by the intrinsic factors of gastric parietal cells and gastric acid. The question of whether homocysteine, as a trigger of arteriosclerosis, was influenced by H. pylori infection was investigated. H. pylori infection induces atrophy of the gastric mucosa, and the function of parietal cells decreases with the atrophy to inactivate its intrinsic factor. The inactivation of the intrinsic factor causes a deficiency of VB₁₂ and folic acid to increase homocysteine's chances of triggering arteriosclerosis. The significance and usefulness of H. pylori eradication therapy was evaluated for its ability to prevent arteriosclerosis that induces lifestyle-related diseases. Persons with positive and negative results of H. pylori infection were divided into a group of those aged 65 years or more (early and late elderly) and a group of those under 65 years of age, and assessed for gastric juice. For twenty-five persons from each group who underwent gastrointestinal endoscopy, the degree of atrophy of the gastric mucosa was observed. Blood homocysteine was measured as a novel index of arteriosclerosis, as well as VB₁₂ and folic acid that affect the metabolism of homocysteine, and then activated by gastric acid and intrinsic factors. Their

  3. [Hypertension and arteriosclerosis].

    Science.gov (United States)

    Sasamura, Hiroyuki; Itoh, Hiroshi

    2011-01-01

    Hypertension is a known risk factor for arteriosclerosis, and causes both atherosclero= sis of medium-large arteries and arteriolosclerosis of the arterioles. Elevated blood pressure causes damage to the endothelium and vascular wall through both mechanical and humoral factors. We and others have shown that inhibition of the renin-angiotensin system at a 'critical period' during the development of hypertension results in a permanent suppression of hypertension in animal models. We have also reported that high-dose renin-angiotensin inhibition results in regression of hypertension, possibly by regression of renal arteriolar hypertrophy. These results suggest that understanding the process of arterial remodeling may play a key role in the development of new strategies for prevention and regression of hypertension and arteriosclerosis.

  4. Balanitis xerotica obliterans in children.

    Science.gov (United States)

    Garat, J M; Chéchile, G; Algaba, F; Santaularia, J M

    1986-08-01

    This report is based on 7 children with balanitis xerotica obliterans. Of these patients 5 had stenosis of the urethral meatus that required meatotomy and the postoperative results were good. The frequency of balanitis xerotica obliterans in children at our center, as well as the findings of other authors, suggests that possibly more cases would be diagnosed during infancy if all dried foreskin were examined systematically.

  5. [Balanitis xerotica obliterans].

    Science.gov (United States)

    Calcagno, C

    2007-01-01

    Balanitis xerotica obliterans (BXO), first described by Stuhmer in 1928, is a chronic, progressive, atrophic, sclerosing process involving prepuce, glans and urethra. Its aetiology is unknown. After a short terminological excursus and a review of the aetiological hypothesis, we have focused on BXO in daily urological practice. We are here describing the clinical presentation and its differential diagnosis with premalignant and malignant lesions of the penis. We tried to define the relationship between BXO and squamous cell carcinoma of the penis. Particular attention was then cast on urethral stenosis. Finally, we focused on the treatment of BXO: corticosteroid local therapy as first line treatment or as adjuvant therapy after circumcision, surgical therapy including circumcision, laser therapy of the glans lesions, meatoplasty in the stenosis of the anterior urethra. We also stressed the need for histological examination of the preputial specimen for a correct follow-up and for medicolegal reasons.

  6. Urethro-balanitis xerotica obliterans.

    Science.gov (United States)

    Mallo, N; Garat, J M; Santaularia, J; Hernandez, J

    1978-01-01

    A clinical report of 5 cases of balanitis xerotica obliterans (BXO) with urethral involvement is presented. Involvement of the urethra in the BXO is emphasized and the fact that this process is often unnoticed, is stressed. The clinical and histological characteristics of this disease are described in its different localizations. Investigations are suggested to diagnose urethral involvement and the suitable therapy is outlined.

  7. 下肢动脉硬化闭塞症误诊为腰椎间盘突出症25例原因分析%Analysis of Lower Limb Arteriosclerosis Obliterans Misdiagnosed as Lumbar Disc Herniation in 25 Patients

    Institute of Scientific and Technical Information of China (English)

    廖传军; 原标; 张望德

    2014-01-01

    目的 分析下肢动脉硬化闭塞症(arteriosclerosis obliterers,ASO)误诊为腰椎间盘突出症的原因及防范措施.方法 对2008年8月—2013年10月收治的25例误诊为腰椎间盘突出症的下肢ASO的病例资料进行回顾性分析.结果 本组表现为下肢疼痛15例,下肢麻木6例,下肢发凉4例;查体均发现足背、胫后动脉搏动消失.外院均诊断为腰椎间盘突出症,后经踝肱指数测定,结合下肢动脉彩色多普勒超声、计算机断层X线血管造影及磁共振血管造影确诊为下肢ASO.18例行经皮血管球囊扩张术及支架置入术,3例行杂交手术,2例行人工血管转流术,余2例仅予药物保守治疗,随访1年症状体征均明显缓解.结论 临床医师应提高对下肢ASO的认识,认真详细询问病史及查体,重视临床资料的综合分析,以提高本病诊治水平.

  8. Stem cells and transplant arteriosclerosis.

    Science.gov (United States)

    Xu, Qingbo

    2008-05-09

    Stem cells can differentiate into a variety of cells to replace dead cells or to repair damaged tissues. Recent evidence indicates that stem cells are involved in the pathogenesis of transplant arteriosclerosis, an alloimmune initiated vascular stenosis that often results in transplant organ failure. Although the pathogenesis of transplant arteriosclerosis is not yet fully understood, recent developments in stem cell research have suggested novel mechanisms of vascular remodeling in allografts. For example, stem cells derived from the recipient may repair damaged endothelial cells of arteries in transplant organs. Further evidence suggests that stem cells or endothelial progenitor cells may be released from both bone marrow and non-bone marrow tissues. Vascular stem cells appear to replenish cells that died in donor vessels. Concomitantly, stem/progenitor cells may also accumulate in the intima, where they differentiate into smooth muscle cells. However, several issues concerning the contribution of stem cells to the pathogenesis of transplant arteriosclerosis are controversial, eg, whether bone marrow-derived stem cells can differentiate into smooth muscle cells that form neointimal lesions of the vessel wall. This review summarizes recent research on the role of stem cells in transplant arteriosclerosis, discusses the mechanisms of stem cell homing and differentiation into mature endothelial and smooth muscle cells, and highlights the controversial issues in the field.

  9. [Portable instrument for arteriosclerosis assessment].

    Science.gov (United States)

    Cao, Shuai; Chen, Xiang

    2014-01-01

    A portable instrument for arteriosclerosis assessment containing sensor module, acquisition board and embedded module was developed for home care in this paper. The sensor module consists of one ECG module and three pulse wave extraction modules, synchronously acquiring human ECG and pulse wave signal of carotid, radial, and dorsal, respectively. The acquisition board converts the sensor module's analog output signals into digital signals and transmits them to the embedded module. The embedded module realizes the functions including signal display, storage and the calculation and output of pulse wave velocity. The structure of the proposed portable instrument is simple, easy to use, and easy to expand. Small size, low cost, and low power consumption are also the advantages of this device. Experimental results demonstrated that the proposed portable instrument for arteriosclerosis assessment has high accuracy, good repeatability and can assess the degree of atherosclerosis appropriately.

  10. Angioscopic assessment of various percutaneous treatments for arteriosclerosis obliterance

    Science.gov (United States)

    Kusaba, Hiroyasu; Watanabe, Kazuo; Shiraishi, Shohzo; Sato, Takashi; Koga, Nobuhiko

    1993-06-01

    We have evaluated the angioscopic findings before and after various percutaneous techniques to treat 39 lesions in 32 cases of arteriosclerosis obliterans (ASO). We applied a laser (CL50: SLT, Japan), percutaneous transluminal angioplasty (PTA), and atherectomy -- either singly or in combination, with angioscopic luminal observation (angioscope: PF14L & PF18L Olympus, Japan) recorded before and after the treatments. In the case of a complete obstruction, we employed PTA as the first choice. We used a laser prior to PTA when the PTA guide-wire failed to penetrate the lumen. For eccentric and calcified lesions atherectomy was applied. A sufficient enlargement was obtained initially in 37 of the 39 lesions. The angioscopic observations after treatment revealed carbonization (3/5) and attachment of small thrombi (3/5) after using the laser, intimal rupture (3/8), dissection (2/8), flap formation (2/8), and attachment of small thrombi (4/8) after PTA, and attachment of small thrombi (9/19), flap formation (6/19), and dissection (2/19) after atherectomy. We established the efficacy of angioscopic assessment demonstrating beneficial clinical results. The angioscopic findings suggest that attachment of small thrombi may be responsible for a poor prognosis. Additional angioscopic observations with angiography are recommended for improved understanding of the luminal changes.

  11. Bronchiolitis Obliterans with Organizing Pneumonia (BOOP)

    Science.gov (United States)

    ... What can you tell me about cryptogenic organizing pneumonia? Answers from Teng Moua, M.D. Previously called bronchiolitis obliterans with organizing pneumonia, cryptogenic organizing pneumonia (COP) is a rare lung ...

  12. Cerebrovascular hemodynamics in patients with cerebral arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    Jianbo Yang; Changcong Cui; Chengbin Wu

    2011-01-01

    The present study observed hemodynamic changes in 26 patients with cerebral arteriosclerosis using a cerebral circulation dynamics detector and transcranial Doppler.In patients with cerebral arteriosclerosis the blood supply and flow rate in the bilateral carotid arteries and the blood flow rate in the anterior cerebral and middle cerebral arteries were similar to normal controls, but the cerebral vascular resistance, critical pressure and pulsatility index were increased, and cerebral arterial elasticity and cerebral blood flow autoregulation were decreased.Compared with the lesioned hemisphere of patients with cerebral infarction, the total blood supply and blood flow rate of patients with cerebral arteriosclerosis were higher.Compared with normal subjects, patients with cerebral arteriosclerosis exhibited cognitive disturbances, mainly in short-term memory, attention, abstract capability, and spatial and executive dysfunction.Results showed that cerebral arteriosclerosis does not directly affect the blood supply of a cerebral hemisphere, but affects cognitive function.The increased cerebral vascular resistance and reduced autoregulation of cerebral blood vessels may be important hemodynamic mechanisms of arteriosclerosis-induced cerebral infarction.

  13. Balanitis xerotica obliterans involving anterior urethra.

    Science.gov (United States)

    Herschorn, S; Colapinto, V

    1979-12-01

    Balanitis xerotica obliterans (BXO) is known to affect the urethral meatus, glans, and prepuce. We describe a case of biopsy-proved BXO that involves not only the usual areas but the anterior urethra as well. Of added interest is the subsequent development of squamous cell carcinoma in the fossa navicularis. The literature is reviewed.

  14. Laser Therapy For Arteriosclerosis: Current Review

    Science.gov (United States)

    Dries, David J.; Pollock, Marc E.; Eugene, John

    1987-03-01

    Shortly after the ruby laser was introduced, in 1959, a study for the use of this ruby laser for the in-vitro dissolution of arteriosclerotic plaque was performed.' With subsequent advances in laser technology and with refined delivery techniques, laser applications to the treatment of arteriosclerosis in the coronary arteries and peripheral vascular system is a reality. This report reviews the disease process, arteriosclerosis, and the ef-forts towards laser treatment of this disease. We conclude with a review of the technical barriers to the routine application of laser energy in arteriosclerotic cardiovascular disease and the progress being made to overcome these obstacles.

  15. Papel de las plaquetas en la arteriosclerosis

    OpenAIRE

    Escolar Albaladejo, Ginés

    1983-01-01

    DE LA TESIS:El término "arteriosclerosis" debe atribuirse a Lobstein, que lo creó en 1833 para referirse a lo que él denominaba: "un aumento del espesor y la dureza de las paredes arteriales". Etimológicamente, la palabra arteriosclerosis se trata de un nombre compuesto por arteria y "sklerosis" que significa espesamiento con induración. Aunque en el lenguaje clínico corriente, se utilizan muy a menudo los conceptos "arterioesclerosis" o "aterosclerosis" de forma indistinta, no es menos cie...

  16. Penile squamous cell carcinoma arising from balanitis xerotica obliterans.

    Science.gov (United States)

    Pride, H B; Miller, O F; Tyler, W B

    1993-09-01

    Squamous cell carcinoma arising from balanitis xerotica obliterans is rarely reported. We describe an 83-year-old man in whom metastatic penile squamous cell carcinoma developed after 18 years of observation for balanitis xerotica obliterans. It is important to recognize the possibility of this uncommon complication of balanitis xerotica obliterans, because survival of patients with squamous cell carcinoma depends on early diagnosis and treatment.

  17. Work-Related Psychosocial Hazards and Arteriosclerosis.

    Science.gov (United States)

    Chou, Li-Ping; Li, Chung-Yi; Hu, Susan C

    2015-01-01

    The association of psychosocial stress with cardiovascular disease (CVD) is still inconclusive. The aim of this study was to examine the relationships between arteriosclerosis and various work-related conditions among medical employees with various job titles.A total of 576 medical employees of a regional hospital in Taiwan with a mean age of 43 years and female gender dominance (85%) were enrolled. Arteriosclerosis was evaluated by brachial-ankle pulse wave velocity (baPWV). Workrelated conditions included job demands, job control, social support, shift work, work hours, sleep duration, and mental health. The crude relationship between each of the selected covariates and baPWV was indicated by Spearman correlation coefficients. A multiple linear regression model was further employed to estimate the adjusted associations of selected covariates with arteriosclerosis.The mean baPWV of participants was 11.4 ± 2.2 m/s, with the value for males being significantly higher than that for females. The baPWV was associated with gender, age, medical profession, work hours, work type, depression, body mass index, systolic and diastolic blood pressures, fasting glucose, and cholesterol. After being fully adjusted by these factors, only sleep duration of less than 6 hours and weekly work hours longer than 60 hours were significantly associated with increased risk of arteriosclerosis. The conditions of job demands, job control, social support, shift work, and depression showed no significant association with baPWV.Longer work hours and shorter sleep durations were associated with an increased risk of arteriosclerosis. These findings should make it easier for the employer or government to stipulate rational work hours in order to avoid the development of cardiovascular disease among their employees.

  18. [Thromboangiitis obliterans (Buerger's disease): update 2015].

    Science.gov (United States)

    Klein-Weigel, Peter; Volz, Theresa Sophie; Richter, Jutta

    2015-10-01

    Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors.

  19. Bronchiolitis obliterans organising pneumonia simulating bronchial carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, J.; Flower, C. [Department of Radiology, Addenbrooke`s Hospital, University of Cambridge Teaching Hospital (United Kingdom); Schnyder, P. [Department of Radiology, University Hospital, Lausanne (Switzerland); Herold, C. [Department of Radiology, University Hospital of Vienna (Austria)

    1998-09-01

    Idiopathic bronchiolitis obliterans organising pneumonia (BOOP) is an uncommon but well-recognised condition that usually presents radiologically as bilateral multifocal patchy areas of consolidation on the chest radiograph and on computed tomography (CT). Five cases are described in which the presenting feature was that of a solitary pulmonary nodule. Four of these nodules showed evidence of cavitation and three patients presented with haemoptysis. In all cases the appearances closely resembled bronchial carcinoma. (orig.) With 5 figs., 21 refs.

  20. The surgical treatment of Balanitis Xerotica Obliterans

    OpenAIRE

    2011-01-01

    Background: Balanitis Xerotica Obliterans (BXO) is a chronic, often progressive disease, which can lead to phimosis and urethral stenosis, affecting both urinary and sexual function. Steroid creams are usually the first-line treatment but have a limited role and surgical intervention is frequently necessary. Conservative surgical procedures (circumcision) are often preferred in the first instance with the premise that recurrence of disease will require a more definitive reconstruction. This s...

  1. Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke.

    Science.gov (United States)

    Daniels, S R; Bates, S; Lukin, R R; Benton, C; Third, J; Glueck, C J

    1982-01-01

    The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical status of 8 children who had familial lipoprotein disorders and evidence of thromboembolic cerebrovascular disease. Six of the 8 children had low levels of plasma high density lipoprotein cholesterol, two had high triglyceride levels, and all came from kindreds characterized by familial lipoprotein abnormalities and premature cardio- and/or cerebrovascular atherosclerosis. Vascular occlusion, irregularities of the arterial lumen, beading, tortuosity, and evidence of collateralization were consistently noted. We speculate that cerebrovascular arteriosclerosis in pediatric ischemic stroke victims who have familial lipoprotein abnormalities may be related to lipoprotein-mediated endothelial damage and thrombosis formation, or to the failure to restore endothelial cells' integrity following damage. The apparent association of lipoproteins and strokes in children and their families merits further exploration, particularly when assessing cerebral angiograms in pediatric ischemic stroke victims. In children with unexplained ischemic cerebrovascular accidents, the diagnostic possibility of occlusive arteriosclerosis with thrombosis must be entertained.

  2. Surgical treatment of balanitis xerotica obliterans.

    Science.gov (United States)

    Campus, G V; Ena, P; Scuderi, N

    1984-04-01

    Balanitis xerotica obliterans, or kraurosis penis, is a chronic progressive scleroatrophic process of the penis, prepuce, and urethral meatus. This syndrome is due to lichen sclerosus et atrophicus of the genital region. We have observed 32 patients, whose ages ranged from 24 to 78, with different clinical and pathologic findings. Clinical symptomatology consisted of painful erection with secondary impotence, burning, itching, and urinary disorders. The treatment in the early stages is pharmacologic; stenosis of the meatus, phimosis, scar adhesions, fissures, and erosions of glans and prepuce prescribe a surgical treatment. We have performed modified circumcision, meatotomy and meatoplasty, removal of the scleroatrophic tract and subsequent grafting. The functional results were satisfactory.

  3. Achromobacter xylosoxidans induced bronchiolitis obliterans in cystic fibrosis.

    Science.gov (United States)

    De Baets, F; Schelstraete, P; Haerynck, F; Van Biervliet, S; De Bruyne, R; Franckx, H; Van Daele, S

    2014-04-01

    We report a 12-year-old boy with progressive bronchiolitis obliterans caused by Achromobacter xylosoxidans (Ax) colonization after liver transplantation, resulting in a steep decline in lung function.

  4. Carbon dioxide laser treatment of balanitis xerotica obliterans.

    Science.gov (United States)

    Ratz, J L

    1984-05-01

    A case of balanitis xerotica obliterans unresponsive to topical therapy is presented. The condition was successfully corrected following epithelial vaporization with the carbon dioxide laser, the patient remaining free of recurrence for 21 months postoperatively.

  5. Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    E. Vandeix

    2012-01-01

    Full Text Available Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS. A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.

  6. Balanitis xerotica obliterans complicating hypospadias repair.

    Science.gov (United States)

    Kumar, M V; Harris, D L

    1999-01-01

    We review the literature and report a series of eight cases of balanitis xerotica obliterans (BXO) developing in patients following primary hypospadias repair. The ages of these patients ranged from 8 to 25 years with BXO developing from 1 to 16 years postoperatively. Six patients were treated by excision of the BXO tissue and two-stage urethroplasties with full-thickness grafts. Three of these patients had further recurrence of BXO and had re-do urethroplasty using a combination of bladder and buccal mucosa. The last two patients in this series had re-do urethroplasty using bladder mucosa only and bladder-buccal mucosa technique, respectively, as first choice for BXO complicating their hypospadias repair.

  7. Penile carcinoma arising in balanitis xerotica obliterans.

    Science.gov (United States)

    Goolamali, S I; Pakianathan, M

    2006-02-01

    Squamous cell carcinoma of the penis is an uncommon cancer, though in one study it accounted for 90% of all penile cancers. Its association with balanitis xerotica obliterans (BXO) is a rare though recognized occurrence. We describe a case of a 46-year-old Caucasian male who first presented to our open-access clinic with a mild phimosis. An elective circumcision was performed and histological examination of the circumcision specimen showed BXO. He was lost to follow-up but re-presented three years later with a persistent tender penile ulcer which on biopsy showed no obvious sinister pathology. He returned a further two years later with a short history of bleeding from the ulcer, and another biopsy now confirmed penile squamous cell carcinoma. Our case emphasizes the importance of regular review of patients with BXO, in particular those with persistent symptoms.

  8. Nitrofurantoin-Associated Bronchiolitis Obliterans Organizing Pneumonia: Report of a Case

    Directory of Open Access Journals (Sweden)

    Mark E Fenton

    2008-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia due to nitrofurantoin has rarely been reported and is associated with poor outcomes. A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented.

  9. Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation.

    Science.gov (United States)

    Hill, Gary S; Nochy, Dominique; Bruneval, Patrick; Duong van Huyen, J P; Glotz, Denis; Suberbielle, Caroline; Zuber, Julien; Anglicheau, Dany; Empana, Jean-Philippe; Legendre, Christophe; Loupy, Alexandre

    2011-05-01

    In biopsies of renal allografts, arteriosclerosis is often more severe than expected based on the age of the donor, even without a history of rejection vasculitis. To determine whether preformed donor-specific antibodies (DSAs) may contribute to the severity of arteriosclerosis, we examined protocol biopsies from patients with (n=40) or without (n=59) DSA after excluding those with any evidence of vasculitis. Among DSA-positive patients, arteriosclerosis significantly progressed between month 3 and month 12 after transplant (mean Banff cv score 0.65 ± 0.11 to 1.12 ± 0.10, P=0.014); in contrast, among DSA-negative patients, we did not detect a statistically significant progression during the same timeframe (mean Banff cv score 0.65 ± 0.11 to 0.81 ± 0.10, P=not significant). Available biopsies at later time points supported a rate of progression of arteriosclerosis in DSA-negative patients that was approximately one third that in DSA-positive patients. Accelerated arteriosclerosis was significantly associated with peritubular capillary leukocytic infiltration, glomerulitis, subclinical antibody-mediated rejection, and interstitial inflammation. In conclusion, these data support the hypothesis that donor-specific antibodies dramatically accelerate post-transplant progression of arteriosclerosis.

  10. Rituximab-Induced Bronchiolitis Obliterans Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    Ahmet B. Ergin

    2012-01-01

    Full Text Available Rituximab-induced lung disease (R-ILD is a rare entity that should be considered in patients treated with rituximab who present with dyspnea, fever, and cough, but no clear evidence of infection. A variety of pathologic findings have been described in this setting. Bronchiolitis obliterans organizing pneumonia (BOOP is the most common clinicopathologic diagnosis, followed by interstitial pneumonitis, acute respiratory distress syndrome (ARDS, and hypersensitivity pneumonitis. Prompt diagnosis and treatment with corticosteroids are essential as discussed by Wagner et al. (2007. Here we present a case of an 82-year-old man who was treated with rituximab for recurrent marginal zone lymphoma. After the first infusion of rituximab, he reported fever, chills, and dyspnea. On computed tomography imaging, he was found to have bilateral patchy infiltrates, consistent with BOOP on biopsy. In our patient, BOOP was caused by single-agent rituximab, in the first week after the first infusion of rituximab. We reviewed the relevant literature to clarify the different presentations and characteristics of R-ILD and raise awareness of this relatively overlooked entity.

  11. TCM Treatment of Thromboangiitis Obliterans -A Report of 64 Cases

    Institute of Scientific and Technical Information of China (English)

    门军章; 门九章

    2005-01-01

    @@ Thromboangiitis Obliterans (TAO), a common peripheral vascular disease with a long illness course and grave sufferings, can cause acromelic gangrene, ulcer and even amputation at the late stage. We have for many years used TCM syndrome differentiation to diagnose and treat the disease with good therapeutic results. The treatment of 64 TAO cases from 2001 to 2002 is reported as follows.

  12. The treatment of balanitis xerotica obliterans with testosterone propionate ointment.

    Science.gov (United States)

    Pasieczny, T A

    1977-01-01

    Balanitis xerotica obliterans (BXO) and kraurosis penis are thought to be synonymous. Clinically and histopathologically they probably represent the same disease process as lichen sclerosus et atrophicus (LSA) but also involve the urethral mucosa. The treatment of choice is considered to be 2 1/2% testosterone propionate ointment which gives better results than strong corticosteroid applications, yet without their side effects.

  13. Continuous wave carbon dioxide treatment of balanitis xerotica obliterans.

    Science.gov (United States)

    Rosemberg, S K; Jacobs, H

    1982-05-01

    Herein is presented the first case of balanitis xerotica obliterans treated successfully by carbon dioxide-continuous wave (CW-CO2) laser vaporization. This method appears to be a safe addition to other well-known treatment modalities, offering minimal postoperative discomfort, preservation of anatomic landmarks and function, and excellent cosmetic results.

  14. Primary sclerosing cholangitis – The arteriosclerosis of the bile duct?

    Directory of Open Access Journals (Sweden)

    Trauner Michael

    2007-01-01

    Full Text Available Abstract Primary sclerosing cholangitis (PSC is a chronic inflammatory disease of unknown aetiology affecting the large bile ducts and characterized by periductal fibrosis and stricture formation, which ultimately result in biliary cirrhosis and liver failure. Arteriosclerosis involves the accumulation of altered lipids and lipoproteins in large arteries; this drives inflammation and fibrosis and ultimately leads to narrowing of the arteries and hypoperfusion of dependent organs and tissues. Knowledge of the causative factors is crucial to the understanding of disease mechanisms and the development of specific treatment. Based on pathogenetic similarities between PSC and arteriosclerosis, we hypothesize that PSC represents "arteriosclerosis of the bile duct" initiated by toxic biliary lipids. This hypothesis is based on common molecular, cellular, and morphological features providing the conceptual framework for a deeper understanding of their pathogenesis. This hypothesis should stimulate translational research to facilitate the search for novel treatment strategies for both diseases.

  15. The surgical treatment of Balanitis Xerotica Obliterans

    Directory of Open Access Journals (Sweden)

    A Hartley

    2011-01-01

    Full Text Available Background: Balanitis Xerotica Obliterans (BXO is a chronic, often progressive disease, which can lead to phimosis and urethral stenosis, affecting both urinary and sexual function. Steroid creams are usually the first-line treatment but have a limited role and surgical intervention is frequently necessary. Conservative surgical procedures (circumcision are often preferred in the first instance with the premise that recurrence of disease will require a more definitive reconstruction. This study looked at patients with pathologically proven BXO referred to the Plastic Surgery Unit at James Cook University Hospital between 2005 and 2009. The aim was to look at their management in the past and subsequent management by us. We also looked at whether early referral of progressive and recurrent BXO patients to reconstructive surgery could have prevented unnecessary delay in resolving symptoms at an earlier stage. Materials and Methods: Data was collected retrospectively and information regarding the exact anatomical location affected, the extent of the disease, the referring specialty and any previous surgical interventions was obtained. Alterations in urinary and sexual function and relief of symptoms following reconstructive surgery were analysed. Results: Of the 23 patients in the study, 43% had previous surgery and 60% of those had undergone two or more procedures. Twenty-one percent of patients had a history of BXO for over five years. Forty-seven percent of patients had alteration in their urinary function and 48% alteration in their sexual function due to the disease, prior to referral. Early results showed remarkable improvement in urinary and sexual function following reconstructive surgery in this group. Conclusions: Steroid creams have been shown to limit the progression of the disease but do not offer a cure in the majority of cases. Circumcision can be a curative procedure in early disease. Although there is conflicting evidence for

  16. Balanitis xerotica obliterans--a review.

    Science.gov (United States)

    Das, S; Tunuguntla, H S

    2000-12-01

    Balanitis xerotica obliterans (BXO) is a scarcely known disease, wrongly considered rare. With a high degree of suspicion and histologic examination, the condition will prove to be much more frequent than one generally believes. The etiology of the condition is unknown at present. Many cases of BXO occurring after circumcision may be cases of secondary phimosis due to BXO not being recognized at the time of surgery. Most of the cases of BXO are seen in the third to fifth decades of life, even though they may occur at the extremes of age. Biopsy of the lesions is not essential in all cases and is indicated to differentiate from penile cancer and in atypical cases. Early diagnosis and treatment of BXO are very important in preventing the urological complications of the diseases such as urethral stricture. Treatment of BXO depends on the anatomic location of the lesions and their extent and severity, together with the rapidity of progression of the disease process. The treatment may vary from topical corticosteroids, laser vaporization in early cases to meatoplasty and urethroplasty in extensive cases. Topical pharmacotherapy is useful in the early stages to reduce the initial symptoms and slow down the progression, but is not effective in all cases and is not the curative treatment of disease. Meatal stenosis, phimosis, scar adhesions, fissures, erosions of glans and prepuce and involvement of the urethra are indications for surgical treatment. Surgery seems to be the only treatment that can relieve the symptoms of advanced disease. Modified circumcision, with total removal of inner preputial layer, definitively relieves phimosis without any recurrence. Meatotomy will not prevent the recurrence of meatal stenosis. Excision of the scleroatrophic tract and grafting of the glans base, coronal sulcus, and the end of the shaft give a complete relief of pain during erection and intercourse in circumcised patients with balanopreputial adhesions and restore the elasticity of

  17. Squamous cell carcinoma of the penis arising from balanitis xerotica obliterans.

    Science.gov (United States)

    Giannakopoulos, X; Basioukas, K; Dimou, S; Agnantis, N

    1996-01-01

    Penile squamous cell carcinoma arising from balanitis xerotica obliterans is rarely reported. We describe a 58-year-old man in whom penile squamous cell carcinoma developed after 25 years of observation for balanitis xerotica obliterans. It is important to recognize the possibility of this uncommon complication of balanitis xerotica obliterans, because survival of patients with squamous cell carcinoma depends on early diagnosis and treatment.

  18. Bronchiolitis obliterans syndrome after lung transplantation: medical treatment.

    Science.gov (United States)

    Verleden, G M

    2000-04-01

    Obliterative bronchiolitis (OB) or the clinical correlate bronchiolitis obliterans syndrome (BOS) is the main cause of late morbidity and mortality after heart-lung and lung transplantation. Although several risk factors for the development of OB/BOS have already been identified, very effective preventive therapy remains Utopian, although there has been much improvement in recent years. This paper attempts to summarize current experience in the medical treatment of OB/BOS, either by tackling the known risk factors for the development of OB/BOS or by changing the immunosuppressive drug regimen for treating established OB/BOS. The current treatment options, however, are rather anecdotal and mostly single-centre experiences. Therefore, multicentre studies are definitely needed to try to identify the most appropriate drug regimen either to prevent and to treat obliterative bronchiolitis/bronchiolitis obliterans syndrome.

  19. Elevated peptides in lung lavage fluid associated with bronchiolitis obliterans syndrome.

    Directory of Open Access Journals (Sweden)

    Matthew D Stone

    Full Text Available OBJECTIVE: The objective of this discovery-level investigation was to use mass spectrometry to identify low mass compounds in bronchoalveolar lavage fluid from lung transplant recipients that associate with bronchiolitis obliterans syndrome. EXPERIMENTAL DESIGN: Bronchoalveolar lavage fluid samples from lung transplant recipients were evaluated for small molecules using ESI-TOF mass spectrometry and correlated to the development of bronchiolitis obliterans syndrome. Peptides associated with samples from persons with bronchiolitis obliterans syndrome and controls were identified separately by MS/MS analysis. RESULTS: The average bronchoalveolar lavage fluid MS spectrum profile of individuals that developed bronchiolitis obliterans syndrome differed greatly compared to controls. Controls demonstrated close inter-sample correlation (R = 0.97+/-0.02, average+/-SD while bronchiolitis obliterans syndrome showed greater heterogeneity (R = 0.86+/-0.09, average+/-SD. We identified 89 features that were predictive of developing BOS grade 1 and 66 features predictive of developing BOS grade 2 or higher. Fractions from MS analysis were pooled and evaluated for peptide content. Nearly 10-fold more peptides were found in bronchiolitis obliterans syndrome relative to controls. C-terminal residues suggested trypsin-like specificity among controls compared to elastase-type enzymes among those with bronchiolitis obliterans syndrome. CONCLUSIONS: Bronchoalveolar lavage fluid from individuals with bronchiolitis obliterans syndrome has an increase in low mass components detected by mass spectrometry. Many of these features were peptides that likely result from elevated neutrophil elastase activity.

  20. High incidence of balanitis xerotica obliterans in boys with phimosis: prospective 10-year study.

    Science.gov (United States)

    Kiss, András; Király, László; Kutasy, Balázs; Merksz, Miklós

    2005-01-01

    This prospective study was designed to address the incidence and clinical and histologic characteristics of balanitis xerotica obliterans in a large random pediatric population with phimosis. We investigated 1178 boys who presented consecutively with phimosis between 1991 and 2001. All patients who underwent complete circumcision and surgical specimens were typed histologically as early, intermediate, or late forms of this disorder or as nonspecific chronic inflammation. Patients with balanitis xerotica obliterans were controlled at 1, 6, and 12 months postoperatively, then yearly. Balanitis xerotica obliterans was found in 471 of the 1178 patients (40%), with the highest incidence in boys aged 9 to 11 years (76%). Secondary phimosis occurred in 93% of boys with balanitis xerotica obliterans and in 32% of those without the disorder. In six instances of balanitis xerotica obliterans, meatotomy and in one meatoplasty was performed, as well as circumcision. On histologic evaluation, we found 19% had early, 60% intermediate, and 21% late form of balanitis xerotica obliterans. Glanular lesions disappeared completely within 6 months in 229 out of 231 patients. Our data strongly suggest that the true incidence of childhood balanitis xerotica obliterans is higher than previously assumed. Its incidence peaks in the 9 to 11 years age group, in whom secondary phimosis was almost exclusively caused by balanitis xerotica obliterans.

  1. Progenitor cells in arteriosclerosis: good or bad guys?

    Science.gov (United States)

    Campagnolo, Paola; Wong, Mei Mei; Xu, Qingbo

    2011-08-15

    Accumulating evidence indicates that the mobilization and recruitment of circulating or tissue-resident progenitor cells that give rise to endothelial cells (ECs) and smooth muscle cells (SMCs) can participate in atherosclerosis, neointima hyperplasia after arterial injury, and transplant arteriosclerosis. It is believed that endothelial progenitor cells do exist and can repair and rejuvenate the arteries under physiologic conditions; however, they may also contribute to lesion formation by influencing plaque stability in advanced atherosclerotic plaque under specific pathologic conditions. At the same time, smooth muscle progenitors, despite their capacity to expedite lesion formation during restenosis, may serve to promote atherosclerotic plaque stabilization by producing extracellular matrix proteins. This profound evidence provides support to the hypothesis that both endothelial and smooth muscle progenitors may act as a double-edged sword in the pathogenesis of arteriosclerosis. Therefore, the understanding of the regulatory networks that control endothelial and smooth muscle progenitor differentiation is undoubtedly fundamental both for basic research and for improving current therapeutic avenues for atherosclerosis. We update the progress in progenitor cell study related to the development of arteriosclerosis, focusing specifically on the role of progenitor cells in lesion formation and discuss the controversial issues that regard the origins, frequency, and impact of the progenitors in the disease.

  2. Economics of health and mortality special feature: race, infection, and arteriosclerosis in the past.

    Science.gov (United States)

    Costa, Dora L; Helmchen, Lorens A; Wilson, Sven

    2007-08-14

    We document racial trends in chronic conditions among older men between 1910 and 2004. The 1910 black arteriosclerosis rate was six times higher than the white 2004 rate and more than two times higher than the 2004 black rate. We argue that blacks' greater lifelong burden of infection led to high arteriosclerosis rates in 1910. Infectious disease, especially respiratory infections at older ages and rheumatic fever and syphilis at younger ages, predicted arteriosclerosis in 1910, suggesting that arteriosclerosis has an infectious cause. Additional risk factors for arteriosclerosis were being born in the second relative to the fourth quarter, consistent with studies implying that atherogenesis begins in utero, and a low body mass index, consistent with an infectious disease origin of arteriosclerosis.

  3. Long-term antibiotic therapy for balanitis xerotica obliterans.

    Science.gov (United States)

    Shelley, W B; Shelley, E D; Grunenwald, M A; Anders, T J; Ramnath, A

    1999-01-01

    In an open uncontrolled study of 3 patients with balanitis xerotica obliterans we have observed significant improvement after long-term systemic antibiotic therapy. Two of the patients noticed softening of the skin as well as disappearance of pruritus, tenderness, and inflammatory changes within 3 weeks of receiving oral and intramuscular penicillin. The third patient experienced the same degree of improvement after a regimen of dirithromycin, 500 mg/day. Stopping the antiobiotic for 1 month resulted in relapse, with improvement again on resumption.

  4. Performance of long-term CT monitoring in diagnosing bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Berstad, Audun E. [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)]. E-mail: a.e.berstad@medisin.uio.no; Aalokken, Trond Mogens [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Kolbenstvedt, Alf [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Bjortuft, Oystein [Department of Thoracic Medicine, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)

    2006-04-15

    Aim: The purpose of the study was to evaluate the ability of CT, including expiratory scans with minimum intensity projection in predicting the development of bronchiolitis obliterans syndrome after lung transplantation. Materials and methods: Forty consecutive patients, 29 bilateral and 11 single lung transplanted, were followed-up with regular scans for a median of 36 months. Air trapping was evaluated on expiratory scans constructed from two short spiral scans with minimum intensity projection-technique, one at the level of the carina and the other midway between the right diaphragm and the carina. Air trapping was scored on a 16-point scale. Bronchiolitis obliterans syndrome was diagnosed according to established clinical criteria and quantified spirometrically. Results: Bronchiolitis obliterans syndrome developed in 17 patients (43%) after a median of 12 months. Air trapping and bronchiectasis was seen before the diagnosis of bronchiolitis obliterans syndrome in only two and one patient, respectively. Interobserver agreement for air trapping score was good (kappa = 0.65). Air trapping scores performed significantly better than that achieved by chance alone in determining the presence of bronchiolitis obliterans syndrome (P = 0.0025). An air trapping score of 4 or more provided the best results with regard to sensitivity and specificity in diagnosing bronchiolitis obliterans syndrome. The sensitivity, specificity, positive and negative predictive values of an air trapping of 4 or more in the diagnosis of bronchiolitis obliterans syndrome were 77, 74, 68 and 81%, respectively. Conclusion: Expiratory CT scans with minimum intensity projection-reconstruction did not predict the development of bronchiolitis obliterans syndrome in most patients. The findings seriously limit the clinical usefulness of long-term CT monitoring for diagnosing bronchiolitis obliterans syndrome after lung transplantation.

  5. Linear opacities on HRCT in bronchiolitis obliterans organising pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, J.M.; Flower, C.D.R. [Dept. of Radiology, Addenbrookes Hospital, Univ. of Cambridge (United Kingdom); Schnyder, P.; Leuenberger, P. [Depts. of Radiology and Medicine, University Hospital, CHUV, Lausanne (Switzerland); Verschakelen, J. [Dept. of Radiology, University Hospital, Leuven (Belgium)

    1999-07-01

    The aim of this study was to report the high-resolution computed tomography (HRCT) appearances of linear opacities that may occur in isolation or in combination with other changes in bronchiolitis obliterans organising pneumonia (BOOP). Eleven patients with BOOP and linear opacities on HRCT were identified at three independent teaching hospitals. The HRCT images and clinical course of each patient were reviewed. Two distinct types of linear opacity were identified. The type-1 opacity extended in a radial manner along the line of the bronchi towards the pleura and was usually intimately related to bronchi. The type-2 opacity occurred in a sub-pleural location and bore no relationship to the bronchi. Both types occurred most commonly in the lower lobes, frequently were associated with multi-focal areas of consolidation and usually completely resolved with treatment. There was no associated bronchiectasis, irreversible volume loss or a reticular or honeycomb pattern. In 2 patients linear opacities were the sole abnormality on HRCT. Bronchiolitis obliterans organising pneumonia may occur in a pure ''linear form'' or HRCT may demonstrate linear opacities in addition to multi-focal consolidation. (orig.)

  6. Immune-Mediated Vascular Injury and Dysfunction in Transplant Arteriosclerosis

    Directory of Open Access Journals (Sweden)

    Anna evon Rossum

    2015-01-01

    Full Text Available Solid organ transplantation is the only treatment for end-stage organ failure but this life-saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels within transplanted organs are targeted by the immune system and the resultant vascular damage is a main contributor to acute and chronic graft failure. The vasculature is a unique tissue with specific immunological properties. This review discusses the interactions of the immune system with blood vessels in transplanted organs and how these interactions lead to the development of transplant arteriosclerosis, a leading cause of heart transplant failure.

  7. Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.

    Science.gov (United States)

    Wakuda, Hirokazu; Uchida, Shinya; Ikeda, Masahiko; Tabuchi, Masaki; Akahoshi, Yasumitsu; Shinozuka, Kazumasa; Yamada, Shizuo

    2014-01-01

    Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of arteriosclerosis or not. We examined the effects of uric acid and curative drugs for hyperuricemia on atherosclerosis-susceptible C57BL/6J apolipoprotein E-deficient (apoE(-/-)) mice. Male apoE(-/-) mice (age: 6 weeks) were fed a normal diet (normal diet group) or a uric acid-enriched diet. Mice fed the uric acid-enriched diet were divided into three groups and administered a drinking vehicle (high uric acid diet group), allopurinol (20 mg·kg(-1)·d(-1)), or benzbromarone (20 mg·kg(-1)·d(-1)) for 10 weeks. Serum uric acid concentrations were higher in the high uric acid diet group than in the normal diet group, and concentrations in the allopurinol and benzbromarone groups were lower than in the high uric acid diet group. Serum total cholesterol and triglyceride levels were lower in the allopurinol group than in the high uric acid diet group. Oxidative stress was lower in the benzbromarone group than in the high uric acid diet group. Atherosclerotic lesion areas were smaller in the allopurinol and benzbromarone groups than in the high uric acid diet group. Thus, hyperuricemia may not be an independent risk factor for arteriosclerosis; however, the administration of allopurinol and benzbromarone prevented the development of atherosclerosis in apoE(-/-) mice fed a uric acid-enriched diet. The anti-atherosclerotic effect was in part due to lower total cholesterol and oxidative stress in the serum. Other possible mechanisms underlying this effect should be investigated.

  8. Bronchiolitis obliterans organizing pneumonia after irradiation therapy for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kitagawa, Satoshi; Aoshima, Masahiro; Ohmagari, Norio; Tada, Hiroshi; Chohnabayashi, Naohiko; Suzuki, Kohyu [Saint Luke' s International Hospital, Tokyo (Japan)

    2003-02-01

    We report three cases of bronchiolitis obliterans organizing pneumonia (BOOP) that developed after irradiation therapy following breast cancer. All patients presented with cough and fever for 3 to 10 months after the completion of irradiation. Chest radiographs and computed tomography (CT) in all three patients demonstrated a consolidation outside the irradiated fields. Their laboratory data revealed increased C-reactive protein and increased erythrocyte sedimentation rates. Transbronchial lung biopsy was performed in all patients, and plugs of granulation tissue in the bronchioles and interstitial infiltration by mononuclear cells were found. Corticosteroid treatment resulted in rapid clinical improvement. BOOP was diagnosed from the histological and clinical findings. Although the etiology of BOOP still remains unknown, there may be a subgroup of such patients in whom the BOOP is induced by irradiation for breast cancer. These cases were assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  9. Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

    Science.gov (United States)

    Cameron, R J; Kolbe, J; Wilsher, M L; Lambie, N

    2000-03-01

    The spectrum of nitrofurantoin lung injury continues to widen. The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury. The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin. Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced. The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP. We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.

  10. Balanitis xerotica obliterans with urethral stricture after hypospadias repair.

    Science.gov (United States)

    Uemura, S; Hutson, J M; Woodward, A A; Kelly, J H; Chow, C W

    2000-01-01

    Three cases of urethral stricture due to balanitis xerotica obliterans (BXO) after hypospadias repair are reported. The first patient showed white, dense scarring on the prepuce before the hypospadias repair and developed a stricture of the urethra after the operation. The second and the third were uneventful for 6 and 2 years, respectively, after the hypospadias repair, and then developed urethral strictures. Pathologic diagnosis of the stenotic lesion is essential. Complete excision of the affected urethra with topical steroid ointment or sublesional triamcinolone injection is recommended for this condition. Although the complication of BXO after hypospadias repair is rare (3 out of 796 cases with hypospadias in our series), surgeons need to be aware of this condition as a cause for late onset of urethral problems.

  11. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells.

    Science.gov (United States)

    Nadig, Satish N; Wieckiewicz, Joanna; Wu, Douglas C; Warnecke, Gregor; Zhang, Wei; Luo, Shiqiao; Schiopu, Alexandru; Taggart, David P; Wood, Kathryn J

    2010-07-01

    Transplant arteriosclerosis is the hallmark of chronic allograft dysfunction (CAD) affecting transplanted organs in the long term. These fibroproliferative lesions lead to neointimal thickening of arteries in all transplanted allografts. Luminal narrowing then leads to graft ischemia and organ demise. To date, there are no known tolerance induction strategies that prevent transplant arteriosclerosis. Therefore, we designed this study to test the hypothesis that human regulatory T cells (T(reg) cells) expanded ex vivo can prevent transplant arteriosclerosis. Here we show the comparative capacity of T(reg) cells, sorted via two separate strategies, to prevent transplant arteriosclerosis in a clinically relevant chimeric humanized mouse system. We found that the in vivo development of transplant arteriosclerosis in human arteries was prevented by treatment of ex vivo-expanded human T(reg) cells. Additionally, we show that T(reg) cells sorted on the basis of low expression of CD127 provide a more potent therapy to conventional T(reg) cells. Our results demonstrate that human T(reg) cells can inhibit transplant arteriosclerosis by impairing effector function and graft infiltration. We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy.

  12. A Rare Complication of Spinal Cord Ischemia Following Endovascular Aneurysm Repair of an Infrarenal Abdominal Aortic Aneurysm with Arteriosclerosis Obliterans: Report of a Case

    Science.gov (United States)

    Matsumoto, Takuya; Matsubara, Yutaka; Inoue, Kentaro; Aoyagi, Yukihiko; Matsuda, Daisuke; Tanaka, Shinichi; Okadome, Jun; Maehara, Yoshihiko

    2016-01-01

    We herein report a case of a rare complication of spinal cord ischemia (SCI) following endovascular aneurysm repair (EVAR). Computed tomography showed stenosis and calcification of bilateral iliac arteries and a saccular aneurysm of the terminal aorta. Paraplegia occurred soon after balloon angioplasty of iliac arteries and EVAR. Cerebrospinal fluid drainage was not performed because the patient was on dual antiplatelet drugs. The patient was treated with intravenous methylpredonisolone and naloxone; however, this did not improve his paraplegia. SCI after EVAR is extremely rare and unpredictable complication, however, physicians should be aware of SCI after EVAR in patients with atherosclerosis. PMID:27738476

  13. [An assessment of the efficacy of intravenous monotherapy with the preparation solcoseryl in patients with arteriosclerosis obliterans of the vessels of the lower extremities].

    Science.gov (United States)

    Luk'ianov, Iu V; Shlomin, V V; Sokurenko, G Iu; Didenko, Iu P; Orlov, N N; Kondrat'ev, V M; Batalin, I V

    2000-01-01

    The authors share their experiences with using Solcoseryl in treatment of 158 patients with obliterating atherosclerosis of the lower extremity vessels. This treatment was found to be very effective. A scheme of the treatment is proposed after which the improved quality of life retains during not less than 6 months in 93% of the patients. The accessory maintenance therapy with minimum doses of aspirin and nicotinic acid is enough between the courses of treatment with Solcoseryl.

  14. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.

    Science.gov (United States)

    Zhang, Jiqin; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang

    2015-05-01

    AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC). While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein). Human genome-wide association study (GWAS) has identified DAB2IP gene variants conferring susceptibility to cardiovascular diseases. Consistently, a global or vascular EC-specific deletion of DAB2IP in mice strongly enhances inflammatory responses and exacerbates atherosclerosis and graft arteriosclerosis progression in mouse models. Mechanisms for AIP1 function and regulation associated with human cardiovascular diseases need further investigations.

  15. Effects of a healthy life exercise program on arteriosclerosis adhesion molecules in elderly obese women

    Science.gov (United States)

    Lim, Seung-Taek; Min, Seok-Ki; Park, Hyuntae; Park, Jong-Hwan; Park, Jin-Kee

    2015-01-01

    [Purpose] The aim of this study was to investigate the change in the arteriosclerosis adhesion molecules after a healthy life exercise program that included aerobic training, anaerobic training, and traditional Korean dance. [Subjects] The subjects were 20 elderly women who were over 65 years of age and had 30% body fat. [Methods] The experimental group underwent a 12-week healthy life exercise program. To evaluate the effects of the healthy life exercise program, measurements were performed before and after the healthy life exercise program in all the subjects. [Results] After the healthy life exercise program, MCP-1 and the arteriosclerosis adhesion molecules sE-selectin and sVCAM-1 were statistically significantly decreased. [Conclusion] The 12-week healthy life exercise program reduced the levels of arteriosclerosis adhesion molecules. Therefore, the results of our study suggest that a healthy life exercise program may be useful in preventing arteriosclerosis and improving quality of life in elderly obese women. PMID:26157257

  16. Interventional therapy experience from the nursing of patients with lower limb arteriosclerosis occlusion syndrome

    Directory of Open Access Journals (Sweden)

    Li-wen ZHU

    2014-10-01

    Full Text Available Objective: To explore the nursing methods of lower limb arteriosclerosis occlusion disease with interventional therapy. Methods: Analyze perioperative nursing for 30 cases of lower limb arteriosclerosis occlusion with stenting and balloon dilatation. Results: 27 cases of patients with stent implantation, 3 cases of balloon dilatation, including 3 cases of late stent patients had bypass surgery, the rest has achieved good nursing effect. Conclusion: Perioperative nursing plays an important role in AOS interventional therapy and early recovery of the patient.

  17. Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts.

    Science.gov (United States)

    Eckl, Sebastian; Heim, Christian; Abele-Ohl, Silke; Hoffmann, Julia; Ramsperger-Gleixner, Martina; Weyand, Michael; Ensminger, Stephan M

    2010-09-01

    Our group has shown that platelet inhibition with clopidogrel, an antagonist of the P2Y12 adenosine diphosphate receptor on platelets, reduced the formation of transplant arteriosclerosis. The aim of this study was to investigate whether a combination of cyclosporin or everolimus with clopidogrel has a beneficial effect on the development of transplant arteriosclerosis. Fully MHC mismatched C57Bl/6 (H2(b)) donor aortas were transplanted into CBA.J (H2(k)) recipients and mice received either clopidogrel alone (1 mg/kg/day) or in combination with cyclosporin (2 mg/kg/day) or everolimus (0.05 mg/kg/day). Grafts were analysed by histology and morphometry on day 30 after transplantation. In mice treated with clopidogrel alone, transplant arteriosclerosis was significantly reduced [intima proliferation 56 +/- 11% vs. 81 +/- 7% (control)/n = 7]. Daily application of everolimus reduced the development of transplant arteriosclerosis compared with untreated controls [intima proliferation of 29 +/- 9% vs. 81 +/- 7% (control)/n = 7]. Strikingly, combination of clopidogrel and everolimus almost abolished the formation of transplant arteriosclerosis [intima proliferation: 11 +/- 8% vs. 81 +/- 7% (control)/n = 7]. By contrast, combination of cyclosporin and clopidogrel compared with clopidogrel alone showed no additive effect. These results demonstrate that combination of platelet- and mammalian target of Rapamycin-inhibition can dramatically reduce the development of transplant arteriosclerosis.

  18. Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.

    Science.gov (United States)

    Yamada, Sohsuke; Wang, Ke-Yong; Tanimoto, Akihide; Guo, Xin; Nabeshima, Atsunori; Watanabe, Takeshi; Sasaguri, Yasuyuki

    2013-09-01

    Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC). Recently, we demonstrated that carotid artery-ligated HDC gene-deficient mice (HDC(-/-)) showed less neointimal formation than wild-type (WT) mice, indicating that histamine participates in the process of arteriosclerosis. However, little is known about the roles of histamine-specific receptors (HHRs) in arteriosclerosis. To define the roles of HHRs in arteriosclerosis, we investigated intimal remodeling in ligated carotid arteries of HHR-deficient mice (H1R(-/-) or H2R(-/-)). Quantitative analysis showed that H1R(-/-) mice had significantly less arteriosclerogenesis, whereas H2R(-/-) mice had more, as compared with WT mice. Bone marrow transplantation from H1R(-/-) or H2R(-/-) to WT mice confirmed the above observation. Furthermore, the increased expression of monocyte chemoattractant protein (MCP-1), platelet-derived growth factor (PDGF), adhesion molecules and liver X receptor (LXR)-related inflammatory signaling factors, including Toll-like receptor (TLR3), interleukin-1 receptor (IL-1R) and tumor necrosis factor receptor (TNF-R), was consistent with the arteriosclerotic phenotype of H2R(-/-) mice. Peripheral progenitor cells in H2R(-/-) mice accelerate ligation-induced arteriosclerosis through their regulation of MCP-1, PDGF, adhesion molecules and LXR-related inflammatory signaling factors. In contrast, peripheral progenitor cells act to suppress arteriosclerosis in H1R(-/-) mice, indicating that HHRs reciprocally regulate inflammation in the ligation-induced arteriosclerosis.

  19. Targeting novel antigens in the arterial wall in thromboangiitis obliterans.

    Directory of Open Access Journals (Sweden)

    Murat Akkus

    2010-06-01

    Full Text Available Thromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis. As little is known about the pathogenesis of the disease, we aimed to determine novel antigens that might be responsible from the local inflammatory reactions and structural changes observed in this disease. An indirect immunoperoxidase technique is used to examine the tissue samples obtained from the dorsalis pedis artery of affected individuals with twenty monoclonal antibodies. Among these several antigens which are not previously reported in TAO like CD34, CD44 and CD90 were determined in the tissue samples examined. On the other hand, many other antigens like cytokine/chemokine receptors, several enzymes and leukocyte/lymphocyte antigens were lacking giving some clues about the local pathological reactions. We briefly discussed our findings for several critical antigens those first described in the present work, possibly having roles in the development of the disease. Expression of the CD90/CD11c receptor/ligand pair seems to play an important role in mononuclear cell recruitment to the damage site. Vascular invasion of not only tunica intima but also the tunica media in affected vessels is clearly demonstrated using endothelial cell specific antigens.

  20. Bronquiolite obliterante na forma nodular Bronchiolitis obliterans in nodular form

    Directory of Open Access Journals (Sweden)

    PAULO DE ALMEIDA

    2002-11-01

    Full Text Available Paciente com 54 anos, do sexo feminino, ex-tabagista, que após duas semanas de um resfriado comum procurou atendimento médico devido a tosse com expectoração amarela, obstrução nasal e desconforto facial. Sua radiografia do tórax mostra lesão nodular no lobo superior esquerdo compatível com nódulo pulmonar solitário. Submetida a uma toracotomia exploradora, foi estabelecido o diagnóstico de bronquiolite obliterante com pneumonia em organização (BOOP.A 54 year old female patient, public servant, ex-smoker, after two weeks of a common cold complained of cough with yellow sputum, nasal obstruction and facial pain. A chest X-ray showed a solitary nodular lesion in the upper left lobe. The patient was submitted to a left thoracotomy, which established the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP.

  1. 血管介入治疗下肢动脉硬化闭塞症20例分析研究%Clinical Analysis of 20 Cases of Arteriosclerosis Occlusive Disease of Lower Extremity Treated with Vascular Interventional Therapy

    Institute of Scientific and Technical Information of China (English)

    解海霞; 金荣

    2016-01-01

    Objective To analyze 20 cases of endovascular treatment of lower limb arteriosclerosis obliterans patients. Methods Hospital from May 2014 to May 2015 using endovascular treatment of lower limb arteriosclerosis obliterans 20 patients during 28 limbs, simple to use, compared with 16 interventional treatment of limb limbs intervention combined surgery is 12 limbs. Results 29 limbs were successfully carried out interventional and surgical treatment, after treatment of symptoms, ankle-brachial index was 0.52 ± 0.16, than preoperative index 0.32 ± 0.11 compared to the significantly improved <0.05.1 strip is used for treatment failure amputation, amputation was 0.36%. Treatment of one case of death within 30 days, the mortality rate was 5%. 20 patients were followed up for 1~72 months, an average of 36 months. Two cases of bypass graft thrombosis, 1 underwent surgical embolectomy, while applying artificial arteries anastomosis ball expanding stent, one case of knee amputation, one case is given conservative treatment. Two cases of iliac and femoral popliteal artery stent a secondary lower limb ischemia, 2 cases of stent occlusion, stenosis, compared with one case, two cases to be balloon-expandable stent secondary, one case of bypass surgery, the patient's symptoms after the adoption of the above treatment They were able to relieve lower extremity symptoms without recurrence. Conclusion The endovascular treatment of lower limb arteriosclerosis obliterans significant effect, can substantially improve the symptoms of patients with lower limb arteriosclerosis obliterans, so that the patient lower limb blood supply recovery, while reducing the incidence of cerebral infarction and amputation rate and mortality.%目的:分析20例血管介入治疗下肢动脉硬化闭塞症患者治疗效果。方法选择我院2014年5月~2015年5月运用血管介入治疗下肢动脉硬化闭塞症患者20例,其间28条肢体,单纯运用介入治疗肢体则为16条肢体,

  2. Bronchiolitis obliterans after allogenic bone marrow transplantation: HRCT findings

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jung Im; Jung, Won Sang; Hahn, Seong Tai; Park, Seog Hee [St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of); Min, Chang Ki; Kim, Chun Choo [College of Medicine, The Catholic University, Seoul (Korea, Republic of)

    2004-06-15

    To evaluate the high resolution computed tomography (HRCT) findings of bronchiolitis obliterans (BO) after bone marrow transplantation (BMT). During the past three years, 11 patients were diagnosed as having BO after BMT when they developed irreversible air flow obstruction, with an FEV{sub 1} value of less than 80% of the baseline value, without any clinical evidence of infection. All 11 patients underwent HRCT, of whom eight also underwent follow-up HRCT. The HRCT images were assessed retrospectively for the presence of decreased lung attenuation, segmental or subsegmental bronchial dilatation, diminution of peripheral vascularity, centrilobular nodules, and branching linear structure on the inspiratory images. The lobar distribution of the decreased lung attenuation and bronchial dilatation was also examined. The presence of air trapping was investigated on the expiratory images. The interval changes of the HRCT findings were evaluated in those patients who had follow-up images. Abnormal HRCT findings were present in all cases; the most common abnormalities were decreased lung attenuation (n=11), subsegmental bronchial dilatation (n=6), diminution of peripheral vascularity (n=6), centrilobular nodules or branching linear structure (n=3), and segmental bronchial dilatation (n=3). Expiratory air trapping was noted in all patients. The decreased lung attenuation and bronchial dilatations were more frequent or extensive in the lower lobes. Interval changes were found in all patients with follow-up HRCT: increased extent of decreased lung attenuation (n=7); newly developed or progressed bronchial dilatation (n=4); and increased lung volume (n=3). HRCT scans are abnormal in patients with BO, with the most commonly observed finding being areas of decreased lung attenuation. While the HRCT findings are not specific, it is believed that their common features can assist in the diagnosis of BO in BMT recipients.

  3. Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

    DEFF Research Database (Denmark)

    Uhlving, H H; Buchvald, F; Heilmann, C J;

    2012-01-01

    Bronchiolitis obliterans (BO) following allogeneic haematopoietic SCT (HSCT) is a serious complication affecting 1.7-26% of the patients, with a reported mortality rate of 21-100%. It is considered a manifestation of chronic graft-versus-host disease, but our knowledge of aetiology and pathogenesis...

  4. Diffuse micronodular pattern of bronchiolitis obliterans organizing pneumonia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, In Jae; Jang, Seung Hun; Min, Kwang Seon; Whang, Im Kyung; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang (Korea, Republic of)

    2006-10-15

    The typical radiographic findings of bronchiolitis obliterans organizing pneumonia (BOOP) are known to be patchy air-space consolidation that is often subpleural, and with or without ground-glass opacities. However, there are scant radiologic reports about the micronodular pattern of BOOP. We report here on a case of BOOP that manifested as diffusely scattered ill-defined centrilobular micronodules on HRCT.

  5. The effect of bronchiolitis obliterans syndrome on health related quality of life

    NARCIS (Netherlands)

    Vermeulen, KM; Groen, H; van der Bij, W; Erasmus, ME; Koeter, GH; TenVergert, EM

    2004-01-01

    Bronchiolitis obliterans syndrome (BOS) is the most important factor limiting long-term survival after lung transplantation, and has a substantial impact on patients' daily life in terms of disability and morbidity. Aim of our study was to examine the effects of BOS on health related quality of life

  6. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis

    NARCIS (Netherlands)

    Kastelijn, E.A.

    2012-01-01

    Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection in the donor lung of the transplant recipient, called bronchiolitis obliterans syndrome (BOS). BOS is diagnosed after lung tr

  7. Case of a congenital urethral duplication being unmasked following circumcision for balanitis xerotica obliterans.

    Science.gov (United States)

    Boyd, Matthew; Woodward, Mark; Lambert, Anthony

    2010-07-01

    We present the case of an 11-year-old boy diagnosed with an Effmann Type II A1 urethral duplication after routine circumcision for balanitis xerotica obliterans (BXO). We discuss the pathophysiology, investigation and management both of BXO and urethral duplication.

  8. Extensive balanitis xerotica obliterans of urethrocutaneous fistula presenting as mass in scrotum.

    Science.gov (United States)

    Kumar, Santosh; Nagappa, Bhubnesh; Ganesamoniv, Raguram

    2010-08-01

    A rare case of extensive lichen sclerosis (balanitis xerotica obliterans) involving the anterior urethra, urethrocutaneous fistula, and scrotum is described in a middle-aged man who presented with a history of obstructive voiding symptoms. He was managed by excision of mass along with the fistulae and staged buccal mucosal urethroplasty.

  9. Study on the classification algorithm of degree of arteriosclerosis based on fuzzy pattern recognition

    Science.gov (United States)

    Ding, Li; Zhou, Runjing; Liu, Guiying

    2010-08-01

    Pulse wave of human body contains large amount of physiological and pathological information, so the degree of arteriosclerosis classification algorithm is study based on fuzzy pattern recognition in this paper. Taking the human's pulse wave as the research object, we can extract the characteristic of time and frequency domain of pulse signal, and select the parameters with a better clustering effect for arteriosclerosis identification. Moreover, the validity of characteristic parameters is verified by fuzzy ISODATA clustering method (FISOCM). Finally, fuzzy pattern recognition system can quantitatively distinguish the degree of arteriosclerosis with patients. By testing the 50 samples in the built pulse database, the experimental result shows that the algorithm is practical and achieves a good classification recognition result.

  10. Obesidad mórbida y arteriosclerosis subclínica

    OpenAIRE

    Megias Rangil, Isabel Clara

    2014-01-01

    La disfunción endotelial, el grosor íntima-media (GIM) y la rigidez arterial se consideran hoy día marcadores de arteriosclerosis precoz. La obesidad y el exceso de peso se han asociado a disfunción endotelial, mayor grosor íntima media y peor rigidez arterial, pero no existen datos concretos sobre el efecto de la obesidad mórbida en estos parámetros. Nuestros objetivos fueron estudiar marcadores de arteriosclerosis subclínica como el GIMc, la función endotelial y la rigidez arterial en un...

  11. Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1α.

    Science.gov (United States)

    Li, J; Liu, S; Li, W; Hu, S; Xiong, J; Shu, X; Hu, Q; Zheng, Q; Song, Z

    2012-08-01

    Transplant arteriosclerosis is a leading cause of late allograft loss. Medial smooth muscle cell (SMC) apoptosis is considered to be an important event in transplant arteriosclerosis. However, the precise contribution of medial SMC apoptosis to transplant arteriosclerosis and the underlying mechanisms remain unclear. We transferred wild-type p53 to induce apoptosis of cultured SMCs. We found that apoptosis induces the production of SDF-1α from apoptotic and neighboring viable cells, resulting in increased SDF-1α in the culture media. Conditioned media from Ltv-p53-transferred SMCs activated PI3K/Akt/mTOR and MAPK/Erk signaling in a SDF-1α-dependent manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation. In a rat aorta transplantation model, lentivirus-mediated BclxL transfer selectively inhibits medial SMC apoptosis in aortic allografts, resulting in a remarkable decrease of SDF-1α both in allograft media and in blood plasma, associated with diminished recruitment of CD90(+)CD105(+) double-positive cells and impaired neointimal formation. Systemic administration of rapamycin or PD98059 also attenuated MSC recruitment and neointimal formation in the aortic allografts. These results suggest that medial SMC apoptosis is critical for the development of transplant arteriosclerosis through inducing SDF-1α production and that MSC recruitment represents a major component of vascular remodeling, constituting a relevant target and mechanism for therapeutic interventions.

  12. Experimental coronary sclerosis induced by immobilization of rabbits: A new model of arteriosclerosis

    Science.gov (United States)

    Tyavokin, V. V.; Tjawokin, W. W.

    1980-01-01

    A new method for producing arteriosclerosis with coronary insufficiency in rabbits by means of immobilization is described and discussed. The experimentally induced atherosclerosis develops due to hypodynamics imposed by the reduced muscular activity without overloading with exogenous cholesterol. The atherosclerosis and coronary insufficiency are associated. With variations in the duration and extent of immobilization, coronary insufficiency alone or with atherosclerosis can be produced.

  13. Coexistence of axial spondyloarthritis and thromboangiitis obliterans in a young woman

    Directory of Open Access Journals (Sweden)

    G. Lopalco

    2015-06-01

    Full Text Available A peculiar coexistence of axial spondyloarthritis and ischemia of the feet and the fourth finger of the left hand in a young woman, who was a heavy smoker, is discussed in this report. This picture was considered within the context of thromboangiitis obliterans. Positivity of anti-nuclear antibodies and mild elevation of inflammatory parameters were noted. Computed tomography angiograms of upper and lower limbs showed luminal narrowing and occlusion of the left humeral, left anterior/posterior tibial and right anterior tibial arteries. Daily iloprost perfusions were started, and smoking cessation was strongly recommended. Coldness and rest pain in the distal extremities improved within a few weeks. The possibility that spondyloarthritis might precede the clinical picture of thromboangiitis obliterans should be considered in heavy smokers.

  14. Histopathological and immunological studies in a cohort of balanitis xerotica obliterans.

    Science.gov (United States)

    Datta, C; Dutta, S K; Chaudhuri, A

    1993-06-01

    Balanitis xerotica obliterans consisting of 52 cases had been studied in the present series. This disease entity is an insidious sclerosing disease of unknown aetiology, affecting mainly the skin and mucous membrane of glans, prepuce and sometimes the fossa navicularis urethrae or even terminal urethra. Atrophic white patches on external genitalia and obstructive uropathy are two common presenting features. It has been classified as local form of lichen sclerosus et atrophicus. Poor local hygiene, circumcision and association of auto-immune diseases like vitiligo are responsible as suggested in this study. Routine tests detected associated cystitis in 8 cases, haematuria in 4 cases, non-reactive VDRL in all cases and impaired glucose tolerance in 5 cases. Immunoglobulin profile (39 cases) showed altered pattern, suggesting some chronic antigenic stimulation. Out of 33 cases where biopsy done, histologically proved typical balanitis xerotica obliterans was found in 19 cases. Malignant change was noted in one case only. Circumcision and dilatation offered temporary relief.

  15. Lupus and pulmonary nodules consistent with bronchiolitis obliterans organizing pneumonia induced by carbamazepine in a man

    OpenAIRE

    Awatef Kelati; Salim Gallouj; Mariame Meziane; Fatima Zahra Mernissi

    2016-01-01

    Several drugs have been implicated in the induction of systemic lupus erythematosus (SLE), but there are only some observations of carbamazepine induced SLE since the first case described in 1966, this drug has also been implicated in the induction of other disorders and rarely pulmonary toxicity; but the occurrence of two rare side effects of this drug: the induced SLE and pulmonary nodules consistent with the bronchiolitis obliterans organizing pneumonia in same patient is really unusual an...

  16. Rapamycin Blocks Fibrocyte Migration and Attenuates Bronchiolitis Obliterans in a Murine Model

    Science.gov (United States)

    Gillen, Jacob R.; Zhao, Yunge; Harris, David A.; LaPar, Damien J.; Stone, Matthew L.; Fernandez, Lucas G.; Kron, Irving L.; Lau, Christine L.

    2014-01-01

    Background Fibrocytes are integral in the development of fibroproliferative disease. The CXCL12/CXCR4 chemokine axis has been shown to play a central role in fibrocyte migration and the development of bronchiolitis obliterans post lung transplantation. Inhibition of the mTOR (mammalian target of rapamycin) pathway with rapamycin has been shown to decrease expression of both CXCR4 and its receptor agonist, CXCL12. Thus, we hypothesize that rapamycin treatment would decrease fibrocyte trafficking into tracheal allografts and prevent bronchiolitis obliterans. Methods A total alloantigenic mismatch, murine heterotopic tracheal transplant model of bronchiolitis obliterans was used. Animals were either treated with rapamycin or dimethyl sulfoxide (DMSO) for 14 days post tracheal transplant. Fibrocyte levels were assessed via flow cytometry, and allograft neutrophil, CD3+ T-cell, macrophage, and smooth muscle actin levels were assessed via immunohistochemistry. Tracheal luminal obliteration was assessed on hematoxylin and eosin stains. Results Compared to DMSO controls, rapamycin-treated mice showed a significant decrease in fibrocyte levels in tracheal allografts. Fibrocytes levels in recipient’s blood showed a similar pattern, although not statistically significant. Furthermore, animals treated with rapamycin showed a significant decrease in tracheal allograft luminal obliteration compared to controls. Based on immunohistochemistry analyses, populations of α-SMA positive cells, neutrophils, CD3+ T-cells, and macrophages were all decreased in rapamycin-treated allograft versus DMSO controls. Conclusions Rapamycin effectively reduces recruitment of fibrocytes into tracheal allografts and mitigates development of tracheal luminal fibrosis. Further studies are needed to determine the cellular and molecular mechanisms that mediate the protective effect of rapamycin against bronchiolitis obliterans. PMID:23561805

  17. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    OpenAIRE

    Hamidun Bunawan; Siti Noraini Bunawan; Syarul Nataqain Baharum; Normah Mohd Noor

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indon...

  18. Bronchiolitis obliterans organizing pneumonia after tangential beam irradiation to the breast. Discrimination from radiation pneumonitis

    Energy Technology Data Exchange (ETDEWEB)

    Nambu, Atsushi; Ozawa, Katsura; Kanazawa, Masaki; Miyata, Kazuyuki [Kofu Municipal Hospital (Japan); Araki, Tsutomu; Ohki, Zennosuke [Yamanashi Medical Coll., Tamaho (Japan)

    2002-06-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) secondary to tangential beam irradiation to the breast, which occurred seven months after the completion of radiotherapy. Although radiation pneumonitis is an alternative consideration, BOOP could be differentiated from it by its relatively late onset and extensive distribution, which did not respect the radiation field. This disease should always be kept in mind in patients with a history of tangential beam irradiation to the breast. (author)

  19. Extensive balanitis xerotica obliterans (BXO) involving the anterior urethra and scrotum.

    Science.gov (United States)

    Singh, Iqbal; Ansari, M S

    2006-01-01

    We describe an unusual case of balanitis xerotica obliterans (BXO) involving the entire anterior urethra and the scrotum that had presented as a palpable nodular scrotal mass with obstructive voiding symptoms in middle aged man. He was managed by a staged urethroplasty. We report the first such case of BXO involving the scrotum resulting in a nodular mass that has not been described and reported till date.

  20. Detection of human papillomavirus types in balanitis xerotica obliterans and other penile conditions.

    OpenAIRE

    1995-01-01

    OBJECTIVES--To determine the prevalence of human papillomavirus (HPV) types 6, 11, 16 and 18 in foreskin biopsies from patients with balanitis xerotica obliterans (BXO) and other penile conditions. MATERIALS AND METHODS--Foreskin biopsy specimens from 24 patients with penile lesions and 5 control patients were analysed by type-specific polymerase chain reaction (PCR). RESULTS--HPV6 or HPV16 were not detected in patients with BXO. HPV6 was detected in 2 controls. CONCLUSIONS--Genital papilloma...

  1. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans

    OpenAIRE

    2016-01-01

    Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder of unclear etiology. The etiology and the exact molecular mechanisms underlying the disease are still unknown. The human transglutaminase (TG) family consists of several proteins with catalytic activity essential for biological processes. In the present research we investigated the transcript levels of three TGs in patients operated on for congenital phimosis without or with histologically confirmed BXO; Thirty childr...

  2. C-peptide promotes lesion development in a mouse model of arteriosclerosis.

    Science.gov (United States)

    Vasic, Dusica; Marx, Nikolaus; Sukhova, Galina; Bach, Helga; Durst, Renate; Grüb, Miriam; Hausauer, Angelina; Hombach, Vinzenz; Rottbauer, Wolfgang; Walcher, Daniel

    2012-04-01

    Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show elevated serum levels of the proinsulin cleavage product C-peptide and immunohistochemical data from our group revealed C-peptide deposition in early lesions of these individuals. Moreover, in vitro studies suggest that C-peptide could promote atherogenesis. This study examined whether C-peptide promotes vascular inflammation and lesion development in a mouse model of arteriosclerosis. ApoE-deficient mice on a high fat diet were treated with C-peptide or control injections for 12 weeks and the effect on lesion size and plaque composition was analysed. C-peptide treatment significantly increased C-peptide blood levels by 4.8-fold without having an effect on glucose or insulin levels, nor on the lipid profile. In these mice, C-peptide deposition in atherosclerotic plaques was significantly increased compared with controls. Moreover, lesions of C-peptide-treated mice contained significantly more macrophages (1.6 ± 0.3% versus 0.7 ± 0.2% positive area; P arteriosclerosis support the hypothesis that C-peptide may have an active role in atherogenesis in patients with diabetes and insulin resistance.

  3. Radiographic manifestations of Mönckeberg arteriosclerosis in the head and neck region

    Energy Technology Data Exchange (ETDEWEB)

    Tahmasbi-Arashlow, Mehrnaz; Barghan, Sevin; Kashtwari, Beeba; Nair, Madhu K. [Oral and Maxillofacial Radiology, Colleges of Dentistry and Medicine, University of Florida, Gainesville (United States)

    2016-03-15

    Mönckeberg sclerosis is a disease of unknown etiology, characterized by dystrophic calcification within the arterial tunica media of the lower extremities leading to reduced arterial compliance. Medial calcinosis does not obstruct the lumina of the arteries, and therefore does not lead to symptoms or signs of limb or organ ischemia. Mönckeberg sclerosis most commonly occurs in aged and diabetic individuals and in patients on dialysis. Mönckeberg arteriosclerosis is frequently observed in the visceral arteries, and it can occur in the head and neck region as well. This report describes a remarkable case of Mönckeberg arteriosclerosis in the head and neck region as detected on dental imaging studies. To the best of our knowledge, this is the first case that has been reported in which this condition presented in the facial vasculature. The aim of this report was to define the radiographic characteristics of Mönckeberg arteriosclerosis in an effort to assist health care providers in diagnosing and managing this condition.

  4. Reduced elastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immuno-osseous dysplasia?

    Directory of Open Access Journals (Sweden)

    Morimoto Marie

    2012-09-01

    Full Text Available Abstract Background Arteriosclerosis and emphysema develop in individuals with Schimke immuno-osseous dysplasia (SIOD, a multisystem disorder caused by biallelic mutations in SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1. However, the mechanism by which the vascular and pulmonary disease arises in SIOD remains unknown. Methods We reviewed the records of 65 patients with SMARCAL1 mutations. Molecular and immunohistochemical analyses were conducted on autopsy tissue from 4 SIOD patients. Results Thirty-two of 63 patients had signs of arteriosclerosis and 3 of 51 had signs of emphysema. The arteriosclerosis was characterized by intimal and medial hyperplasia, smooth muscle cell hyperplasia and fragmented and disorganized elastin fibers, and the pulmonary disease was characterized by panlobular enlargement of air spaces. Consistent with a cell autonomous disorder, SMARCAL1 was expressed in arterial and lung tissue, and both the aorta and lung of SIOD patients had reduced expression of elastin and alterations in the expression of regulators of elastin gene expression. Conclusions This first comprehensive study of the vascular and pulmonary complications of SIOD shows that these commonly cause morbidity and mortality and might arise from impaired elastogenesis. Additionally, the effect of SMARCAL1 deficiency on elastin expression provides a model for understanding other features of SIOD.

  5. The Inhibitory Effect of Astilbin on the Arteriosclerosis of Murine Thoracic Aorta Transplant

    Institute of Scientific and Technical Information of China (English)

    Jinping ZHAO; Ping LI; Yunfeng ZHANG; Xianguo WANG; Qilin AO; Sihai GAO

    2009-01-01

    The inhibitory effect of astilbin on transplant arteriosclerosis in murine model of thoracic aorta transplantation was examined.Model of rat thoracic aorta transplantation was established.Ninety rats were divided into three groups.In isograft group,the thoracic aorta of Brown Norway (BN) rat was anastomosed with the abdominal aorta of another BN rat.In allograft group,the thoracic aorta of BN rat was anastomosed with the abdominal aorta of Lewis rat.In astilbin group,the rats receiving allo-transplantation were given astiibin 5 mg/kg per day for a time of 28 days.The donor thoracic aorta and the recipient abdominal aorta were anastomosed by means of a polyethylene cannula (inner diameter:1.5 mm,length:3 mm length).The grafts were histologically examined for structural changes.The areas of arterial lumen and endatrium were calculated.Our results showed that,in the allograft group,28 days after aliografting,conspicuous proliferation of smooth muscles and infiltration with a great number of inflammatory cells were found in the tunica intima and tunica media.Astilbin significantly inhibited the proliferation of smooth muscles and ameliorated the infiltration of inflammatory cells thereyby prevent against the development of transplant arteriosclerosis.It is concluded that asltilbin can effectively prevent the development of arteriosclerosis in allotrausplant by inhibiting the proliferation of smooth muscles and inhibit the proliferation of smooth muscles in tunica of intima and media and reducing infiltration of the inflammatory cells.

  6. The Non-Invasive Functional Tissue Characterization for Arteriosclerosis by Artery Wall Motion Analysis with Time Series High-Speed Echo Images and Continuous Spygmo-Manometer

    Science.gov (United States)

    2007-11-02

    Abstract- The evaluation method of arteriosclerosis has been established, but most of them are invasive way. In late years, non-invasive diagnostic...method for arteriosclerosis can be done by the diagnosis with high resolution echography. However, even this new diagnostic method can not diagnose...until beginning the morphologic changes of the arteries by stenosis. There is little value even if it could be detected the arteriosclerosis after the

  7. Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

    Directory of Open Access Journals (Sweden)

    Rafaela C.S. De Paula

    2014-12-01

    General significance: In the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries.

  8. Lupus and pulmonary nodules consistent with bronchiolitis obliterans organizing pneumonia induced by carbamazepine in a man

    Directory of Open Access Journals (Sweden)

    Awatef Kelati

    2016-10-01

    Full Text Available Several drugs have been implicated in the induction of systemic lupus erythematosus (SLE, but there are only some observations of carbamazepine induced SLE since the first case described in 1966, this drug has also been implicated in the induction of other disorders and rarely pulmonary toxicity; but the occurrence of two rare side effects of this drug: the induced SLE and pulmonary nodules consistent with the bronchiolitis obliterans organizing pneumonia in same patient is really unusual and -to our knowledge- the second observation reported in the literature.

  9. Bronchiolitis obliterans organizing pneumonia after adjuvant thoracic radiotherapy for breast cancer. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Katsuyasu; Ogasawara, Tomohiko; Akita, Yuko; Miyazaki, Mikinori; Inukai, Akihiro; Shinjo, Keiko; Suzuki, Masayuki [Nagoya Daini Red Cross Hospital (Japan)

    2001-02-01

    We report a case of recurrent cough and migratory pulmonary infiltrates in a 55-year-old woman after adjuvant thoracic radiotherapy for breast cancer. The pulmonary infiltrates were initially limited to the area adjacent to the irradiated breast, but later migrated to the opposite lung. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was made using transbronchial biopsy, which disclosed intraluminal fibrosis in the distal airspace, together with a radiographic appearance typical of BOOP. This case was assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  10. 小儿闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    陈强

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,是一种相对少见而严重的慢性阻塞性肺病.其主要临床特点是反复或持续气促、喘息或咳嗽,运动耐力差,肺部有细湿啰音和喘鸣音,对支气管扩张剂无反应[1].

  11. Urethral stone presenting as a stop valve--a rare complication of balanitis xerotica obliterans.

    Science.gov (United States)

    Dogra, P N; Singh, I; Khaitan, A

    2001-01-01

    Balanitis xerotic obliterans (BXO) is the genital subcategory of lichen sclerosis et atrophicus. The association of BXO with urethral stone causing interruption of the urinary stream and voiding by manual displacement of the urethral stone has not been described before. We describe one such case of a young boy with BXO and urethral stone who voided by manually displacing the stone for over a year. The case is reported to emphasize the ingenuity of the patient in continuing to void for over a year despite the association of the impacted urethral stone with urethral stricture and BXO.

  12. Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.;

    2009-01-01

    BACKGROUND: Post-transplant baseline forced expiratory volume in 1 second (FEV(1)) constitutes a systematic bias in analyses of bronchiolitis obliterans syndrome (BOS). This retrospective study evaluates risk factors for BOS adjusting for the confounding of post-transplant baseline FEV(1). METHODS...

  13. Full-thickness skin grafts from eyelids to penis, plus split-thickness grafts in chronic balanitis xerotica obliterans.

    Science.gov (United States)

    Rudolph, R; Walther, P

    1997-02-01

    Balanitis xerotica obliterans is a progressive, sclerotic, constrictive scar-forming disease process of the penile prepuce that can involve the frenulum and urethral meatus. Full-thickness skin grafting from the upper eyelids supplemented with split-thickness skin grafting was successfully used in a patient to end a 57-year symptomatic course.

  14. EFECTO DE DIFERENTES ACIDOS GRASOS SOBRE LOS MARCADORES INFLAMATORIOS EN ARTERIOSCLEROSIS EN RATON

    OpenAIRE

    TORREJON SILVA ; CLAUDIA PAOLA

    2010-01-01

    Los ácidos grasos poliinsaturados de cadena larga n-3 (AGPICL) son nutrientes esenciales que tienen una función anti-inflamatoria y disminuyen el riesgo de enfermedad cardiovascular. Esta tesis examina el efecto de AGPICL n-3 comparado los AG saturados sobre la expresión de los principales efectores moleculares que están involucrados en los procesos aterogénicos previo al desarrollo de la arteriosclerosis como enfermedad. 48 ratones machos C57BL/6 (12 semanas de edad) fueron asignados e...

  15. Correlation Between Arteriosclerosis and Periodontal Condition Assessed by Lactoferrin and α1-Antitrypsin Levels in Gingival Crevicular Fluid.

    Science.gov (United States)

    Hayashi, Shuji; Yamada, Hirotsugu; Fukui, Makoto; Ito, Hiro-o; Sata, Masataka

    2015-01-01

    Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment of periodontal disease been proven to prevent atherosclerotic vascular disease. Therefore, the aim of the present study was to examine the correlation between periodontal condition and arteriosclerosis in patients with coronary artery disease (CAD), which is usually accompanied by systemic arteriosclerosis.We measured levels of gingival crevicular fluid lactoferrin (GCF-Lf) and α1-antitrypsin (GCF-AT) in 72 patients (67 ± 8 years, 56 men) with CAD. Furthermore, we evaluated the maximum intima-media thickness (max IMT) and plaque score of the carotid arteries as well as brachial-ankle pulse wave velocity (baPWV) and flow-mediated dilation (FMD) of the brachial artery, each of which is a parameter for determining arteriosclerosis status. The average level of GCF-Lf was 0.29 ± 0.36 µg/mL and that of GCF-AT was 0.31 ± 0.66 µg/mL, with significant correlation between the two (r = 0.701, P arteriosclerosis parameters (ie, max IMT, plaque score, baPWV, and FMD) and GCF-Lf or GCF-AT.No correlation between the GCF biomarkers and the severity of arteriosclerosis was detected. This result may suggest that worsening of the periodontal condition assessed by GCF biomarkers is not a major potential risk factor for arteriosclerosis.

  16. Biopsy-verified bronchiolitis obliterans and other noninfectious lung pathologies after allogeneic hematopoietic stem cell transplantation

    DEFF Research Database (Denmark)

    Uhlving, Hilde Hylland; Andersen, Claus B; Christensen, Ib Jarle

    2015-01-01

    Bronchiolitis obliterans (BO) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Lung biopsy is the gold standard for diagnosis. This study describes the course of BO and assesses the congruity between biopsy-verified BO and a modified version of the National...... Institutes of Health's consensus criteria for BO syndrome (BOS) based exclusively on noninvasive measures. We included 44 patients transplanted between 2000 and 2010 who underwent lung biopsy for suspected BO. Of those, 23 were diagnosed with BO and 21 presented other noninfectious pulmonary pathologies......, and maximal mid-expiratory flow throughout follow-up, but there was no difference in the change in pulmonary function from the time of lung biopsy. The BO diagnosis was not associated with poorer overall survival. Fifty-two percent of patients with biopsy-verified BO and 24% of patients with other...

  17. Successful treatment of Bronchiolitis obliterans with organizing pneumonia in dialysis patient

    Directory of Open Access Journals (Sweden)

    Vivek B Kute

    2012-01-01

    Full Text Available A 42-year-old end stage renal disease (ESRD patient was admitted with fever, anorexia, malaise, non-productive cough, and dyspnea, of one-week duration. Multiple cultures of the blood, sputum, and urine were negative for microorganisms. The possibility of bronchiolitis obliterans with organizing pneumonia (BOOP was considered when patient with pulmonary infiltrate did not respond to conventional antibiotic therapy and frequent hemodyalisis. High-resolution computed tomography of the chest revealed patchy air-space consolidation, ground-glass opacities, and small nodular opacities, predominantly located at the peripheral part of the lungs. Cultures and stains of bronchoalveolar lavage (BAL specimen and bronchoscopic biopsy of lung tissue were negative for organisms [bacteria, mycobacterium tuberculosis, PCP, fungus, and atypical organism] and showed evidence of BOOP. Patient recovered completely with early diagnosis and treatment with steroids and underwent successful renal transplantation with wife as donor without postoperative complication and relapse.

  18. APOL1 Risk Alleles Are Associated With More Severe Arteriosclerosis in Renal Resistance Vessels With Aging and Hypertension

    Directory of Open Access Journals (Sweden)

    Michael D. Hughson

    2016-05-01

    Discussion: With the limitation of the small number of subjects contributing to the positive results, the findings imply that APOL1 risk alleles recessively augment small-vessel arteriosclerosis in conjunction with age and hypertension. Focal segmental glomerulosclerosis was not a significant finding, indicating that in the early stages of arterionephrosclerosis, the primary pathologic influence of APOL1 genotype is vascular rather than glomerular.

  19. Unaltered levels of transplant arteriosclerosis in the absence of the B cell homing chemokine receptor CXCR5.

    Science.gov (United States)

    Ensminger, Stephan M; Abele-Ohl, Silke; Ohl, Lars; Spriewald, Bernd M; Ramsperger-Gleixner, Martina; Weyand, Michael; Förster, Reinhold

    2009-03-01

    Chemokine receptors and their ligands are crucial for lymphocyte trafficking under both homeostatic and inflammatory conditions. The chemokine receptor CXCR5 controls B cell migration and the organization of B cell follicles. The aim of this study was to investigate the impact of CXCR5 on the development of transplant arteriosclerosis. Fully MHC mismatched BALB/c (H2(d)) donor aortas were transplanted into C57BL/6-CXCR5(-/-) (H2(b)), C57BL/6-CXCR5(+/-) (H2(b)) or C57BL/6-CXCR5(+/+) (H2(b)) recipients. Grafts were analysed by morphometry and immunofluorescence and intra-graft cytokine mRNA production was analysed by RT-PCR. Transplant arteriosclerosis was evident in CXCR5+/+ and CXCR5+/- mice and only mildly reduced in CXCR5-/- recipients indicating that absence of CXCR5 had no substantial effect on the development of transplant arteriosclerosis. Analysis of the cellular infiltrate of aortic grafts implanted in CXCR5-/- recipients revealed no differences in the number of T-cells, macrophages and B cells as compared to controls. Intra-graft cytokine production showed no significant changes in Th1 (IL-12) and Th2 (IL-4) cytokines as well as in TGF-beta and iNOS production. These data suggest that lack of CXCR5 expression by recipient T- and B-cells has little effect on the development of transplant arteriosclerosis.

  20. Hybrid procedure on revascularization of arteriosclerosis obliterans on lower extremity%杂交手术在下肢动脉硬化性闭塞症血管重建中的价值

    Institute of Scientific and Technical Information of China (English)

    凌平; 肖乐; 龚昆梅; 王昆华; 欧阳一鸣

    2010-01-01

    目的 探讨杂交手术在下肢动脉硬化性闭塞症血管重建中的应用价值.方法 回顾性分析本院1998年1月至2009年8月收治血管重建的56例下肢动脉硬化性闭塞症多节段病变患者的临床资料,其中杂交手术32例,外科手术13例,血管腔内治疗11例.探讨3种血管重建方法在多节段病变血管重建的适应证、治疗效果、并发症及围手术期死亡率.结果 随访36例,随访时间2~101个月,平均随访时间53个月,随访率64.29%.杂交手术组远期通畅率明显高于外科手术和腔内治疗组(62.50% vs 30.76% vs 27.27%,ANOVA分析,F=54.17,P<0.05);临床疗效明显优于外科手术和腔内治疗组(有效率分别为56.25%、15.38%、13.64%,ANOVA分析,F=58.46,P<0.05;无效率分别为12.5%、61.54%、54.55%,ANOVA分析,F=54.23,P<0.05).并发症明显低于外科手术组,与腔内治疗组相当(12.5% vs 38.46% vs 18.19%,ANOVA分析,F=52.56,P<0.05).围手术期死亡率杂交手术和腔内治疗组均为0%,外科手术组为7.69%.结论 杂交手术对多节段病变患者更具优势,不仅能减少和降低麻醉及手术风险,而且能获得满意的临床疗效和远期通畅率.

  1. 老年动脉硬化闭塞症常见中医证候的计量诊断研究%The Quantitative Diagnosis of Common Chinese Medicine Syndromes in Senile Arteriosclerosis Obliterans

    Institute of Scientific and Technical Information of China (English)

    熊卫红; 赵晖; 陈家旭; 胡立胜; 张葆现; 章新根

    2012-01-01

    Objective To research the quantitative diagnosis of three common Chinese medicine syndromes in arteriosclerotic obliteration (ASO) through establishing the differential diagnosis table for syndrome index measurement. Methods The syn-dromes information of 179 ASO patients was collected by epidemiological cross-sectional surveys. The differential diagnosis ta-ble for ASO syndrome index measurement was established with sum of index and the diagnostic threshold was determined. The sum of index was used to do the quantitative differential diagnosis on the basis of the diagnostic threshold. The efficiency of the differential diagnosis table for ASO syndrome index measurement was evaluated through backward-looking and forward-looking test. Results The diagnostic threshold of syndrome of cold congealing in the vessels and networks, syndrome of blood stasis in the vessels and networks and syndrome of stasis heat in the vessels and networks was 426, 404 and 406 respectively. The sensitivity and specificity of three syndromes were all above 90%, the diagnosing coincident rate were all above 97% and the misdiagnosing rate and missed diagnosing rate were all below 6%. Conclusion The differential diagnosis table for ASO syn-drome index measurement, sum of index and the critical value of sum of index is effective and functional for quantitative diagno-sis of Chinese medicine syndromes.%目的 通过建立动脉硬化闭塞症(ASO)证候指数计量鉴别诊断表,对ASO 3个常见中医证候进行计量诊断研究.方法 采用流行病学横断面调查方法,收集179例ASO患者证候资料,用指数和法建立ASO证候指数计量鉴别诊断表,确定ASO证候的诊断临界值,在诊断临界值的基础上运用指数和法做定量鉴别诊断,并通过回代性检验和前瞻性检验对ASO证候指数计量鉴别诊断表的诊断效能进行评价.结果 脉络寒凝证的诊断临界值为426;脉络血瘀证的诊断临界值为404,脉络瘀热证的诊断临界值为406.回代性和前瞻性检验的诊断效能评价中,3个证候的灵敏度、特异度均在90%以上,诊断符合率均在97%以上,误诊率、漏诊率均在6%以下.结论 ASO证候指数计量鉴别诊断表及指数和、指数和临界值法对其中医证候计量诊断具有良好的诊断效能与临床实用价值.

  2. A case of radiation pulmonary injury simulating bronchiolitis obliterans organizing pneumonia following postoperative radiotherapy for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Katoh, Toshiyuki; Iwata, Masaru; Yoshida, Norio; Katagiri, Akira; Takeda, Naoya [Kariya General Hospital, Aichi (Japan)

    2001-09-01

    A 57-year-old female underwent conservative surgery for a left sided breast cancer, and received 48 Gy postoperative radiation therapy. One year later, a chest CT scan disclosed bilateral patchy ground glass opacities. She had no subjective symptom. These abnormal opacities disappeared spontaneously without any treatment. We considered this was a radiation lung injury simulating bronchiolitis obliterans organizing pneumonia. We emphasize that the symptomless and spontaneous resolution of this type of lung injury should be kept is mind. (author)

  3. Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: Experience of 15 cases

    OpenAIRE

    2014-01-01

    Objectives: Balanitis xerotica obliterans (BXO) related strictures involving the external urethral meatus. We reviewed our result with the use of circular mucosal graft in the reconstruction of strictures. Methods: Between March 1997 and January 2012, 15 patients underwent circular buccal mucosal urethroplasy for BXO related anterior urethral strictures. Urethral catheter was removed within 2 weeks. Follow-up included patient symptoms assessment, cosmetic outcome and uroflowmetry. Results: Me...

  4. A RARE CASE REPORT OF SQUAMOUS CELL CARCINOMA OF URETHRA ARISING FROM SUBSTITUTED PENILE SKIN FLAP WITH BALANITIS XEROTICA OBLITERANS

    OpenAIRE

    2016-01-01

    A 44-year-old male presented with ulcerative growth over dorsal penile shaft along with multiple urethrocutaneous fistula. A total penectomy, scrotal excision and perineal urethrostomy were done. Past history of treatment for penile urethral stricture due to Balanitis Xerotica Obliterans (BXO) by substitution urethroplasty using pedicled preputial penile skin flap five years back. On gross as well as histopathological examination, the tumour was found to be arising from the skin ...

  5. Mouse model of alloimmune-induced vascular rejection and transplant arteriosclerosis.

    Science.gov (United States)

    Enns, Winnie; von Rossum, Anna; Choy, Jonathan

    2015-05-17

    Vascular rejection that leads to transplant arteriosclerosis (TA) is the leading representation of chronic heart transplant failure. In TA, the immune system of the recipient causes damage of the arterial wall and dysfunction of endothelial cells and smooth muscle cells. This triggers a pathological repair response that is characterized by intimal thickening and luminal occlusion. Understanding the mechanisms by which the immune system causes vasculature rejection and TA may inform the development of novel ways to manage graft failure. Here, we describe a mouse aortic interposition model that can be used to study the pathogenic mechanisms of vascular rejection and TA. The model involves grafting of an aortic segment from a donor animal into an allogeneic recipient. Rejection of the artery segment involves alloimmune reactions and results in arterial changes that resemble vascular rejection. The basic technical approach we describe can be used with different mouse strains and targeted interventions to answer specific questions related to vascular rejection and TA.

  6. Bronchiolitis Obliterans

    Science.gov (United States)

    ... dangerous chemicals to avoid: Acetaldehyde Acetaldehyde is in cannabis and e-cigarette smoke. It irritates the skin, ... infections, a connective tissue disorder such as rheumatoid arthritis , a medication reaction, and after a bone marrow, ...

  7. On the treatment of cerebral arteriosclerosis from treating turbid blood%脑动脉硬化症从血浊论治探微

    Institute of Scientific and Technical Information of China (English)

    韩萍; 周永红; 唐明; 郭瑞友

    2016-01-01

    The thesis explores the mechanism of the treatment of cerebral arteriosclerosis from treating turbid blood by exploring the correlation between the turbid blood and cerebral arteriosclerosis, it elaborates that turbid blood is the pathological pivot of cerebral arteriosclerosis, therefore, purifying turbid blood is a vital measure in preventing and treating cerebral arteriosclerosis.%从血浊与脑动脉硬化症发病的相关性入手,深入探讨脑动脉硬化症从血浊论治的机理,论述血浊是脑动脉硬化症发病的病理枢纽,而清化血浊法为防治脑动脉硬化症的重要措施。

  8. Vacuum-compression therapy for ischemic disease of the extremities:experience with 40 patients

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To study the clinical effects of vacuum-compression therapy for ischemic disease of the extremities. Methods A total of 40 cases of peripheral arterial disorders,including 23 thromboangiitis obliterans (31 limbs) and 17 arteriosclerosis obliterans (23 limbs),were treated by a self-made vacuum-compression therapeutic apparatus. Results The effective rate in thromboangiitis obliterans and arteriosclerosis obliterans groups was 96.77% and 92.23%,respectively. The cuffs on the apparatus were improved ...

  9. Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans.

    Directory of Open Access Journals (Sweden)

    Cara N Halldin

    Full Text Available BACKGROUND: Bronchiolitis obliterans, an irreversible lung disease, was first associated with inhalation of butter flavorings (diacetyl in workers at a microwave popcorn company. Excess rates of lung-function abnormalities were related to cumulative diacetyl exposure. Because information on potential excess mortality would support development of permissible exposure limits for diacetyl, we investigated respiratory-associated mortality during 2000-2011 among current and former workers at this company who had exposure to flavorings and participated in cross-sectional surveys conducted between 2000-2003. METHODS: We ascertained workers' vital status through a Social Security Administration search. Causes of death were abstracted from death certificates. Because bronchiolitis obliterans is not coded in the International Classification of Disease 10(th revision (ICD-10, we identified respiratory mortality decedents with ICD-10 codes J40-J44 which encompass bronchitis (J40, simple and mucopurulent chronic bronchitis (J41, unspecified chronic bronchitis (J42, emphysema (J43, and other chronic obstructive pulmonary disease (COPD (J44. We calculated expected number of deaths and standardized mortality ratios (SMRs with 95% confidence intervals (CI to determine if workers exposed to diacetyl experienced greater respiratory mortality than expected. RESULTS: We identified 15 deaths among 511 workers. Based on U.S. population estimates, 17.39 deaths were expected among these workers (SMR = 0.86; CI:0.48-1.42. Causes of death were available for 14 decedents. Four deaths among production and flavor mixing workers were documented to have a multiple cause of 'other COPD' (J44, while 0.98 'other COPD'-associated deaths were expected (SMR = 4.10; CI:1.12-10.49. Three of the 4 'other COPD'-associated deaths occurred among former workers and workers employed before the company implemented interventions reducing diacetyl exposure in 2001. CONCLUSION: Workers

  10. Feasibility of microvascular head and neck reconstruction in the setting of calcified arteriosclerosis of the vascular pedicle.

    Science.gov (United States)

    Lee, Matthew K; Blackwell, Keith E; Kim, Brandon; Nabili, Vishad

    2013-03-01

    OBJECTIVE To report outcomes in free flap reconstructive surgery in the setting of calcified arteriosclerosis affecting the flap pedicle. DESIGN Retrospective review, including a detailed analysis of medical records, histopathologic findings, and a comprehensive review of the literature. METHODS A total of 1329 consecutive microvascular free tissue transfers were performed by 2 reconstructive surgeons at a university-affiliated tertiary care medical center from January 1, 1996, through December 31, 2011. Clinical notes, operative notes, and pathology reports were systematically reviewed to identify 44 patients (3%) with calcified arteriosclerosis involving the flap vascular pedicle. A comprehensive medical record review was performed for the included patients, detailing patient-related characteristics, flap survival, and incidence of perioperative complications. RESULTS A history of arteriosclerosis was identified preoperatively in 18 patients (41%). Eight patients (18%) were specifically recognized clinically and histologically to have a variant of arteriosclerosis known as Mönckeberg medial calcific sclerosis. In total, fibula osteocutaneous free flap was performed in 30 patients, radial forearm in 8 patients, rectus abdominus in 3 patients, latissimus dorsi in 2 patients, and parascapular in 1 patient. Perioperative complications occurred in 17 patients (39%), with the most common being pulmonary (14%) and cardiac (9%). Patient follow-up ranged from 3 to 137 months, with a mean postoperative follow-up of 21 months. The mean length of hospital stay was 12 days. There was a 0% incidence of total flap failure and a 7% incidence of partial flap necrosis. CONCLUSION Although technically challenging, successful microvascular free flap reconstruction can be achieved despite the presence of vascular calcifications affecting the flap vascular pedicle.

  11. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Science.gov (United States)

    Bunawan, Hamidun; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd.

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr. PMID:26413127

  12. Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study

    Science.gov (United States)

    Politano, Gianfranco; Inghilleri, Simona; Morbini, Patrizia; Calabrese, Fiorella; Benso, Alfredo; Savino, Alessandro; Cova, Emanuela; Zampieri, Davide; Meloni, Federica

    2016-01-01

    The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the study of BOS. The analysis considered the full set of miRNAs annotated in miRBase (version 21), and applied a sequence of filtering approaches and statistical analyses to reduce this set and to score the candidate miRNAs according to their potential involvement in BOS development. Dysregulation of two of the selected candidate miRNAs–miR-34a and miR-21 –was clearly shown in in-situ hybridization (ISH) on five explanted human BOS lungs and on a rat model of acute and chronic lung rejection, thus definitely identifying miR-34a and miR-21 as pathogenic factors in BOS and confirming the effectiveness of the computational pipeline. PMID:27564214

  13. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

    Directory of Open Access Journals (Sweden)

    Ching-Chang Cheng

    2011-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia (BOOP is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS, typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2 was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs, extracellular collagen matrix (ECM deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (<.05. Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.

  14. Oxygen-sensitive {sup 3}He-MRI in bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Gast, Klaus K. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, Mainz (Germany); Biedermann, Alexander [Klinikum der Johannes Gutenberg-Universitaet, 3. Medizinische Klinik, Pulmonologie, Mainz (Germany); Herweling, Annette [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Anaesthesiologie, Mainz (Germany); Schreiber, Wolfgang G. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, MR-Physik, Mainz (Germany); Schmiedeskamp, Joerg [Max-Planck-Institut fuer Polymerforschung, Mainz (Germany); Mayer, Eckhard [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Herz-, Thorax- und Gefaesschirurgie, Mainz (Germany); Heussel, Claus P. [Abteilung fuer Radiologie, Thoraxklinik Heidelberg, Heidelberg (Germany); Markstaller, Klaus; Eberle, Balthasar [Inselspital/Universitaetsspital, Klinik fuer Anaesthesiologie, Bern (Switzerland); Kauczor, Hans-Ulrich [Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany)

    2008-03-15

    Oxygen-sensitive {sup 3}He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO{sub 2}) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive {sup 3}He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acquired on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, {sup 3}He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO{sub 2} in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive {sup 3}He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive {sup 3}He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients. (orig.)

  15. Two cases of bronchiolitis obliterans organizing pneumonia syndrome after the radiation of breast-conserving therapy

    Energy Technology Data Exchange (ETDEWEB)

    Komuro, Youko; Nakagomi, Hiroshi; Akaike, Hidenori; Chiba, Shigehiro; Miyashita, Yoshihiro; Obu, S.; Yamaguchi, Motoshi; Oyama, Toshio [Yamanashi Prefectural Central Hospital, Kofu (Japan)

    2001-12-01

    Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a recently reported complication of the adjuvant radiotherapy of breast-conserving surgery. We report two cases of BOOP syndrome in 100 patients who underwent breast-conserving therapy. A 75 year-old woman had a cough 3 months after radiation therapy for cancer of the left breast. Chest radiography and computed tomography showed consolidation with air bronchograms in the upper left lung. Transbronchial lung biopsy showed lymphocyte infiltration and fibrosis in the alveoli. A 45-year old woman with bilateral breast cancer had a cough and palpitations for 3 month after radiation therapy for cancer of the right breast. Chest radiography and computed tomography showed consolidation in upper and middle fields of the left lung. Transbronchial lung biopsy showed granulation formation in the alveolar duct, which is a typical feature of BOOP. The symptoms and radiographic findings improved with oral administration of prednisolone. BOOP syndrome may occur as a complication of breast-conserving therapy. (author)

  16. Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?

    Energy Technology Data Exchange (ETDEWEB)

    Mihara, Naoki; Johkoh, Takeshi [Osaka Univ., Suita (Japan). Medical School; Ichikado, Kazuya (and others)

    2000-10-01

    In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases. The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated. Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP. For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance. (author)

  17. Bronchiolitis obliterans following exposure to sulfur mustard: chest high resolution computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Ghanei, Mostafa E-mail: m.ghanei@bmsu.ac.ir; Mokhtari, Majid; Mohammad, Mehdi Mir; Aslani, Jafar

    2004-11-01

    Background: Pulmonary complications are known to occur in over half of the patients exposed to sulfur mustard (SM). Chemical weapons of mass destruction (WMD) including SM were used by Iraq during Iran-Iraq war between 1983 and 1989. We undertook this study to evaluate the chest high resolution computerized tomography (HRCT) as a diagnostic tool in patients with documented exposure to SM and chronic respiratory symptoms. Method: The medical records of 155 patients exposed to SM during Iran-Iraq war and suffered respiratory complications were reviewed. Chest HRCTs of these patients were examined. Ten healthy controls with no history of exposure to HD were matched for age, gender, and chest HRCT protocol applied. Results: Fifty chest HRCTs of these patients were randomly selected for this study. The most frequent findings were; air trapping 38 (76%), bronchiectasis 37 (74%), mosaic parenchymal attenuation (MPA) 36 (72%), irregular and dilated major airways 33 (66%) bronchial wall thickening (BWT) 45 (90%), and interlobular septal wall thickening (SWT) 13 (26%), respectively. Air trapping in one patient (10%) was the only positive finding in the control group. Conclusions: Chest HRCT findings of bronchiectasis, air trapping, MPA, SWT, and BWT were seen in our patients 15 years after exposure to HD. These findings suggest the diagnosis of bronchiolitis obliterans (BO). We did not encounter chest HRCT features consistent with pulmonary fibrosis.

  18. Sauropus androgynus (L. Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Directory of Open Access Journals (Sweden)

    Hamidun Bunawan

    2015-01-01

    Full Text Available Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr.

  19. Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment

    Directory of Open Access Journals (Sweden)

    Hamidreza Abtahi

    2016-10-01

    Full Text Available Bronchiolitis obliterans (BO is the most remarkable pulmonary sequels of war-related sulfur mustard inhalation. There is little if any data about long-term efficacy of associated BO treatment. Five years spirometric records of three groups of patients with obstructive pulmonary diseases (asthma, COPD, BO and documented sulfur mustard inhalation were evaluated. The BO patients were treated with inhaled Seretide 125-250/25 (2 puffs BID, azithromycin (250 mg, three times/week and N-acetylcysteine (1200-1800/day. Asthma and COPD patients were treated according to existing guidelines. Seventy-three (38 asthma, 16 COPD and 19 BO patients completed the 5 years follow-up. Basal and final FEV1 in BO patients (2.69±0.81 and 2.39±0.65 respectively were not significantly different from COPD patients (2.46±0.56 and 1.96±0.76 respectively. There was also no significant difference between the yearly FEV1 decline in BO patients compared to COPD patients (60±84 cc vs. 99±79 cc respectively, P=0.163. The non-significant difference of FEV1 decline in BO compared to COPD patients suggests the effectiveness of azithromycin, inhaled steroid and N-acetyl cysteine in BO patients. Considering safety and possible effectiveness, this treatment is recommended until more data is available from controlled clinical studies.

  20. Biopsy-verified bronchiolitis obliterans and other noninfectious lung pathologies after allogeneic hematopoietic stem cell transplantation.

    Science.gov (United States)

    Uhlving, Hilde Hylland; Andersen, Claus B; Christensen, Ib Jarle; Gormsen, Magdalena; Pedersen, Karen Damgaard; Buchvald, Frederik; Heilmann, Carsten; Nielsen, Kim Gjerum; Mortensen, Jann; Moser, Claus; Sengeløv, Henrik; Müller, Klaus Gottlob

    2015-03-01

    Bronchiolitis obliterans (BO) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Lung biopsy is the gold standard for diagnosis. This study describes the course of BO and assesses the congruity between biopsy-verified BO and a modified version of the National Institutes of Health's consensus criteria for BO syndrome (BOS) based exclusively on noninvasive measures. We included 44 patients transplanted between 2000 and 2010 who underwent lung biopsy for suspected BO. Of those, 23 were diagnosed with BO and 21 presented other noninfectious pulmonary pathologies, such as cryptogenic organizing pneumonia, diffuse alveolar damage, interstitial pneumonia, and nonspecific interstitial fibrosis. Compared with patients with other noninfectious pulmonary pathologies, BO patients had significantly lower values of forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity, and maximal mid-expiratory flow throughout follow-up, but there was no difference in the change in pulmonary function from the time of lung biopsy. The BO diagnosis was not associated with poorer overall survival. Fifty-two percent of patients with biopsy-verified BO and 24% of patients with other noninfectious pulmonary pathology fulfilled the BOS criteria. Pathological BO diagnosis was not superior to BOS criteria in predicting decrease in pulmonary function beyond the time of biopsy. A lung biopsy may provide a characterization of pathological patterns that can extend our knowledge on the pathophysiology of HSCT-related lung diseases.

  1. Bronquiolite obliterante com pneumonia em organização Bronchiolitis obliterans organizing pneumonia

    Directory of Open Access Journals (Sweden)

    Gabriela Addor

    2004-04-01

    Full Text Available Uma paciente 48 anos apresentou-se, assintomática, mas com achado radiológico de condensações alveolares, algumas constituindo nódulos em lobo superior direito, lobo médio e língula com predomínio perihilar. Foi considerado o diagnóstico diferencial de neoplasia, sarcoidose, doenças granulomatosas e tuberculose, entre outras doenças. O diagnóstico de bronquiolite obliterante com pneumonia em organização foi estabelecido através de videotoracoscopia e foi iniciado o tratamento com esteróides. Houve boa evolução com resolução radiológica.48 years-old woman, asymptomatic, presented with radiographic findings of patchy airspace consolidation with nodular opacities in the upper right lobe, middle lobe and lingula. The differential diagnoses of neoplasms, sarcoidosis, granulomatous diseases and tuberculosis were considered. Diagnosis of Bronchiolitis obliterans organizing pneumonia was made by means of videothoracoscopy whereupon treatment with corticosteroids was begun. The patient had a positive evolution with resolution of the radiographic finding.

  2. Long standing balanitis xerotica obliterans resulting in renal impairment in a child.

    Science.gov (United States)

    Sandler, Gideon; Patrick, Emily; Cass, Danny

    2008-08-01

    Balanitis xerotica obliterans (BXO) is the most common cause of pathological phimosis in boys. Presented here is the case of a previously well 13-year-old boy who developed obstructive renal impairment (serum creatinine = 190 micromol/l) at least in part from phimosis due to BXO. A circumcision and, 2.5 months later, meatal dilatation were done. Nine months after his initial presentation, his serum creatinine returned to a permanently elevated nadir of 119 mumol/l. Presentation with the complications of phimosis can be delayed in teenage boys because they may feel embarrassed to come forward. Circumcision remains the definitive treatment of BXO induced phimosis though if the penile meatus is involved, more complex surgery is sometimes required. Topical steroids are useful for residual disease. Follow-up is very important due to the frequent involvement of the skin of the glans. In the very long term there is an increased chance of penile malignancy, which can occur even after circumcision.

  3. [Topical therapy of balanitis xerotica obliterans in childhood. Long-term clinical results and an overview].

    Science.gov (United States)

    Ebert, A-K; Vogt, T; Rösch, W H

    2007-12-01

    Balanitis xerotica obliterans (BXO) is a chronic and progressive dermatitis of unknown aetiology and incidence. Its management in childhood is controversial. Although in most cases only the prepuce is affected, meatal and urethral involvement may lead to major surgical reconstruction. Therefore complete surgical excision of the affected skin is considered to be mandatory. In case of involvement, incidental histological evidence or a relapse, or when complete removal of the affected skin is not possible, a topical therapy should be implemented. In a retrospective analysis of our study population (13 children) with BXO, relapse rate was lower after topical therapy with tacrolimus (Protopic), a highly selective immune modulator, than after the standard anti-inflammatory therapy with betamethasone. The use of tacrolimus ointment is a safe therapy with no severe side effects. Due to the fact that there are no predictive factors for progression or relapse of BXO, we consider a topical anti-inflammatory therapy is always indicated after any type of surgery for BXO. Follow-up monitoring should be close, so that any relapse can be detected and treated as early as possible.

  4. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.

    Science.gov (United States)

    Russo, Tiziana; Currò, Monica; Barbera, Anna; Caccamo, Daniela; Antonuccio, Pietro; Arena, Salvatore; Montalto, Angela Simona; Parisi, Saveria; Marseglia, Lucia; Gitto, Eloisa; Ientile, Riccardo; Impellizzeri, Pietro; Romeo, Carmelo

    2016-09-14

    Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder of unclear etiology. The etiology and the exact molecular mechanisms underlying the disease are still unknown. The human transglutaminase (TG) family consists of several proteins with catalytic activity essential for biological processes. In the present research we investigated the transcript levels of three TGs in patients operated on for congenital phimosis without or with histologically confirmed BXO; Thirty children with acquired phimosis were enrolled. The removed foreskins were sent both for histological diagnosis and for quantitative real-time PCR to evaluate the transcript levels of keratinocyte (TG1), tissue (TG2), and epidermal (TG3) transglutaminase; We observed a decrease in TG1 and TG3 transcripts by about 70% (p BXO (n = 15) in comparison with patients without BXO (n = 15) and an increase in TG2 mRNA levels by 2.9 folds (p BXO and can be a consequence of damage to keratinocytes. Increased expression of TG2 can be the result of chronic inflammation. TG2 overexpression can play a pivotal role in triggering and maintaining the inflammatory response in BXO patients.

  5. [Balanitis xerotica obliterans with phimosis in elderly patients presenting with difficulty in urination].

    Science.gov (United States)

    Nemoto, Kaoru; Ishidate, Takuzo

    2013-06-01

    Eight elderly patients (average age 76.1±4.3 years) with balanitis xerotica obliterans (BXO) accompanied by phimosis presented with difficulty in urination. Preoperative average international prostate symptom score, average maximum urinary flow rate, and average volume of residual urine were 20.7±6.3 points (n=8), 5.1±3.6 ml/s (n=5), and 85.4±77.3 ml (n=8), respectively. Some of the patient's complaints, such as severe dribbling of urine, urinary stream division, and ballooning of the foreskin, were not included in the items of the major questionnaire on urination. Dorsal incision and circumcision was performed in all patients, and all were pathologically diagnosed with BXO. Meatoplasty was performed in one patient with a meatal stenosis. No coexistence of penile cancer was observed. Statistically significant improvements were observed in subjective and objective findings after treatment. In conclusion, BXO with phimosis in elderly patients should be considered as a cause of lower urinary tract symptoms.

  6. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans

    Directory of Open Access Journals (Sweden)

    Tiziana Russo

    2016-09-01

    Full Text Available Balanitis xerotica obliterans (BXO is a chronic inflammatory skin disorder of unclear etiology. The etiology and the exact molecular mechanisms underlying the disease are still unknown. The human transglutaminase (TG family consists of several proteins with catalytic activity essential for biological processes. In the present research we investigated the transcript levels of three TGs in patients operated on for congenital phimosis without or with histologically confirmed BXO; Thirty children with acquired phimosis were enrolled. The removed foreskins were sent both for histological diagnosis and for quantitative real-time PCR to evaluate the transcript levels of keratinocyte (TG1, tissue (TG2, and epidermal (TG3 transglutaminase; We observed a decrease in TG1 and TG3 transcripts by about 70% (p < 0.001 in foreskins from patients with BXO (n = 15 in comparison with patients without BXO (n = 15 and an increase in TG2 mRNA levels by 2.9 folds (p < 0.001; Reduced expression of both TG1 and TG3 was associated with the altered structure of the foreskin in BXO and can be a consequence of damage to keratinocytes. Increased expression of TG2 can be the result of chronic inflammation. TG2 overexpression can play a pivotal role in triggering and maintaining the inflammatory response in BXO patients.

  7. Papel de los macrófagos en la patogénesis de la arteriosclerosis

    Directory of Open Access Journals (Sweden)

    Quintana Varón María del Pilar

    2007-12-01

    Full Text Available La arteriosclerosis es una enfermedad inflamatoria que es responsable del 50% de las muertes del mundo
    occidental por desencadenar complicaciones coronarias graves. Se produce por la acumulación excesiva de
    colesterol proveniente del torrente sanguíneo en la íntima arterial de arterias medias y grandes. Los monocitos circulantes se adhieren al endotelio activado y se diferencian en macrófagos al interior de la íntima
    arterial, donde se desempeñan como recolectores del exceso de colesterol. Desde ahí liberan citoquinas,
    proteasas, especies reactivas de oxigeno y factores de crecimiento que potencian la reacción inflamatoria,
    desempeñando un papel esencial en la patogénesis de la enfermedad. La población creciente de macrófagos
    eventualmente entra en apoptosis y necrosis, haciendo cada vez más grande e inestable la lesión arteriosclerótica, lo que en último momento es el detonante de las complicaciones clínicas graves que pueden terminar en la muerte del paciente.

  8. Clinical studies of cerebral arteriosclerosis in diabetic subjects. Analysis with brain MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Ohashi, Makoto; Tanahashi, Hideo (Osaka Rosai Hospital, Sakai (Japan)); Nomura, Makoto; Yamada, Yoshio; Abe, Hiroshi

    1994-11-01

    In order to investigate the clinical characteristics of cerebral arteriosclerosis in diabetic subjects, brain MRI studies were conducted in diabetic patients and healthy subjects. The subjects were 93 diabetic patients without symptoms and signs of cerebral infarction (49 males and 44 females) with a mean age of 59 years and 73 healthy subjects (43 males and 30 females) with a mean age of 57 years. The MRI studies were performed on a General Electric 1.5-T signa system. The spin-echo technique (T2-weighted image) was used with a pulse repetition time (TR) of 2,500 msec and echo time (TE) of 80 msec. The quantitative evaluation of cerebral infarction was assessed using personal computer and image-scanner. By MRI, the incidence of cerebral infarction in diabetic patients was significantly higher than that in healthy subjects (30.1% vs. 13.7%, respectively, p<0.05). The mean age of the diabetic patients with cerebral infarctions was higher than that of those without cerebral infarctions. Hypertension and diabetic nephropathy were present more frequently in the subjects with cerebral infarctions. These data suggest that it is important to delay the onset and slow the progression of cerebral infarction in diabetic patients by strict blood glucose control and management of blood pressure. (author).

  9. 闭塞性细支气管机化性肺炎%Bronchiolitis obliterans organizing pneumonia

    Institute of Scientific and Technical Information of China (English)

    卢宏柱; 赵亮

    2011-01-01

    @@ 闭塞性细支气管机化性肺炎(bronchiolitis obliterans organizing pneumonia,BOOP)是一个临床病理术语,其特征是以细支气管腔、肺泡管以及一些肺泡有肉芽组织形成,伴有间质和气腔内不同程度的单核细胞和泡沫巨噬细胞的浸润[1-2].

  10. Pulmonary radiation injury manifested by signs of bronchiolitis obliterans with organizing pneumonia after postoperative breast cancer radiotherapy

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    Ogata, Kenichi; Shibata, Kazumi; Nishio, Tetsuo [Kitakyusyu Municipal Medical Center, Fukuoka (Japan); Kawarada, Yuji; Hara, Nobuyuki

    1999-12-01

    A 67-year-old woman underwent surgery for cancer of both breast (right: mastectomy, left: conserving surgery), and received 60 Gy radiation to the left postoperative breast. Three months later, cough and fever developed. A chest radiograph demonstrated infiltrative shadows in the left lung field. Transbronchial lung biopsy specimens disclosed organizing exudates in the alveolar spaces and bronchioles. After treatment with prednisolone, the clinical symptoms and radiographic infiltrates disappeared. This was a case of pulmonary radiation injury pathologically manifested by signs of bronchiolitis obliterans with organizing pneumonia. (author)

  11. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

    Directory of Open Access Journals (Sweden)

    Ronaldo Soares Martins

    2012-10-01

    Full Text Available The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP. Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV treatment.

  12. A RARE CASE REPORT OF SQUAMOUS CELL CARCINOMA OF URETHRA ARISING FROM SUBSTITUTED PENILE SKIN FLAP WITH BALANITIS XEROTICA OBLITERANS

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    Rana Pratap

    2016-06-01

    Full Text Available A 44-year-old male presented with ulcerative growth over dorsal penile shaft along with multiple urethrocutaneous fistula. A total penectomy, scrotal excision and perineal urethrostomy were done. Past history of treatment for penile urethral stricture due to Balanitis Xerotica Obliterans (BXO by substitution urethroplasty using pedicled preputial penile skin flap five years back. On gross as well as histopathological examination, the tumour was found to be arising from the skin flap used for substitution. This case highlights the malignant potential of skin affected by BXO and is probably the only case report where a skin flap has turned malignant.

  13. Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    MO Xiao-dong; XU Lan-ping; LIU Dai-hong; ZHANG Xiao-hui; CHEN Huan; CHEN Yu-hong; HAN Wei

    2013-01-01

    Background The occurrence of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (alIo-HSCT) is rare but severe.We examine the role of pre-HSCT chemotherapeutic exposure,pre-HSCT comorbidities,and transplant-related complications in the development of BOS after allo-HSCT.Methods A nested case-control study was designed.Cases with BOS and controls matched for the year of alIo-HSCT and length of the follow-up were identified from a cohort of 1646 patients who underwent alIo-HSCT for treatment of hematologic malignancies between 2006 and 2011.Antithymocyte globulin was used in the partial matched related and unrelated matched donor HSCT,or patients with severe aplastic anemia.Results Thirty-six patients suffered from BOS; the mean age at the time of presentation was (32.7±12.4) years,and the mean time to presentation was (474±350) days post-HSCT.A pre-HSCT cyclophosphamide dose of >3.2 g/m2 (OR=8.74,P=0.025),chronic graft-versus-host disease (moderate to severe) (OR=12.02,P=0.000),and conditioning regimens without antithymocyte globulin (OR=2.79,P=0.031) were independently associated with BOS.Conclusions We found that higher pre-HSCT cyclophosphamide exposure,a conditioning regimen without antithymocyte globulin,and moderate to severe chronic graft-versus-host disease are significantly and independently associated with BOS.Based on these results,we can identify patients who are at a higher risk of developing BOS after alIo-HSCT,select a more appropriate therapeutic strategy,and improve the outcome of HSCT recipients.

  14. Diagnosis of occlusive lesions of upper extremity arteries in patients with thromboangiitis obliterans.

    Science.gov (United States)

    Pokrovskiĭ, A V; Kuntsevich, G I; Dan, V N; Chupin, A V; Kalinin, A A; Alekperov, R T; Makhmudova, L S

    2003-01-01

    The study accrued 84 patients suffering from thromboangiitis obliterans (TO) examined and treated at the A.V. Vishnevsky Institute of Surgery, RAMS, over the period 1988 to 2002. Based on the complaints on the part of the upper extremities the patients were distributed into four groups. Sixteen (19.1%) TO patients did not make any complaints on the part of the arms (degree I ischemia). Thirty-eight (45.2%) patients complained of numbness and paresthesia, chiefly of the tips of the fingers on both hands (degree II ischemia). Six (7.1%) persons complained of pains in the hands at physical exercise (decree III ischemia). Ulcers and necroses of the fingers were present in 24 (28.6%) patients (degree IV ischemia). The diagnostic procedures for arterial lesion of the upper extremities included laboratory investigations, duplex scanning of the great arteries, of the arteries of the hands, fingers and nail matrix, wide-field capillaroscopy, oxygen tension measurements, and angiography as well. Comparison of the clinical manifestations of arterial lesion of the upper extremities in TO patients to the data supplied by different research methods has revealed a direct correlation between the degree of ischemia and the pathomorphological as well as functional changes which increased as the ischemic syndrome was aggravated. As a result of the present work, there have been studied and systematized the criteria for the diagnosis of the degree of arterial lesion of the upper extremities in TO patients, based on the data, supplied by duplex scanning, capillaroscopy, measurements of transcutaneous oxygen tension and angiography. In addition, there has been studied the role of the humoral component of immunity in the delineation of inflammatory activity in patients with TO.

  15. Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans.

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    He, T; Qu, B H; Wang, D L; Hu, M

    2015-06-18

    We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining). The animals were killed at various times following the operation and serum and muscle tissues were sampled. For the sham group: the endometrium was relatively intact; medial membrane and epineurium lesions were absent; and blood vessels and surrounding tissues had no inflammatory cell infiltration. For the model group: all subgroups displayed inflammation; large numbers of inflammatory cells were gathered; muscle tissue lost its normal texture and structure; and the internal elastic membrane was integrated. Compared with the preoperative status, HIF-1α expression increased significantly in all subgroups (P < 0.05); there was no change in the sham group. HIF-1α expression in each subgroup was different (F = 14.267, P < 0.05). Femoral artery injection of lauric acid can be used as a rat TO model owing to its simple application and success rate. HIF-1α expression increased in the early stage of TO and gradually decreased with the extension of ischemia time; it may play a leading role in TO development and can be used for diagnosis and cure evaluation.

  16. Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome

    Science.gov (United States)

    Zhang, Su-Bei; Sun, Xin; Wu, Qi; Wu, Jun-Ping; Chen, Huai-Yong

    2016-01-01

    Background: Bronchiolitis obliterans syndrome (BOS) often develops in transplant patients and results in injury to the respiratory and terminal airway epithelium. Owing to its rising incidence, the pathogenesis of BOS is currently an area of intensive research. Studies have shown that injury to the respiratory epithelium results in dysregulation of epithelial repair. Airway epithelial regeneration is supported by stromal cells, including fibroblasts. This study aimed to investigate whether the supportive role of lung fibroblasts is altered in BOS. Methods: Suspensions of lung cells were prepared by enzyme digestion. Lung progenitor cells (LPCs) were separated by fluorescence-activated cell sorting. Lung fibroblasts from patients with BOS or healthy controls were mixed with sorted mouse LPCs to compare the colony-forming efficiency of LPCs by counting the number of colonies with a diameter of ≥50 μm in each culture. Statistical analyses were performed using the SPSS 17.0 software (SPSS Inc., USA). The paired Student's t-test was used to test for statistical significance. Results: LPCs were isolated with the surface phenotype of CD31- CD34- CD45- EpCAM+ Sca-1+. The colony-forming efficiency of LPCs was significantly reduced when co-cultured with fibroblasts isolated from patients with BOS. The addition of SB431542 increased the colony-forming efficiency of LPCs to 1.8%; however, it was still significantly less than that in co-culture with healthy control fibroblasts (P < 0.05). Conclusion: The epithelial-supportive capacity of fibroblasts is impaired in the development of BOS and suggest that inefficient repair of airway epithelium could contribute to persistent airway inflammation in BOS. PMID:27569228

  17. Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome

    Institute of Scientific and Technical Information of China (English)

    Su-Bei Zhang; Xin Sun; Qi Wu; Jun-Ping Wu; Huai-Yong Chen

    2016-01-01

    Background:Bronchiolitis obliterans syndrome (BOS) often develops in transplant patients and results in injury to the respiratory and terminal airway epithelium.Owing to its rising incidence,the pathogenesis of BOS is currently an area of intensive research.Studies have shown that injury to the respiratory epithelium results in dysregulation of epithelial repair.Airway epithelial regeneration is supported by stromal cells,including fibroblasts.This study aimed to investigate whether the supportive role of lung fibroblasts is altered in BOS.Methods:Suspensions of lung cells were prepared by enzyme digestion.Lung progenitor cells (LPCs) were separated by fluorescence-activated cell sorting.Lung fibroblasts from patients with BOS or healthy controls were mixed with sorted mouse LPCs to compare the colony-forming efficiency of LPCs by counting the number of colonies with a diameter of≥50 μm in each culture.Statistical analyses were performed using the SPSS 17.0 software (SPSS Inc.,USA).The paired Student's t-test was used to test for statistical significance.Results:LPCs were isolated with the surface phenotype ofCD31-CD34-CD45-EpCAM+Sca-1 +.The colony-forming efficiency of LPCs was significantly reduced when co-cultured with fibroblasts isolated from patients with BOS.The addition ofSB431542 increased the colony-forming efficiency of LPCs to 1.8%;however,it was still significantly less than that in co-culture with healthy control fibroblasts (P < 0.05).Conclusion:The epithelial-supportive capacity of fibroblasts is impaired in the development of BOS and suggest that inefficient repair of airway epithelium could contribute to persistent airway inflammation in BOS.

  18. Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients.

    Science.gov (United States)

    Villa, Massimo; Dragonetti, Emanuele; Grande, Michele; Bove, Pierluigi; Sansalone, Salvatore; Rulli, Francesco; Tambucci, Roberto; Tucci, Gianfranco; Baldi, Alfonso

    2012-01-01

    The association between balanitis xerotica obliterans (BXO) and skin disorders is long established, however, the role of skin phototype and local trauma in its onset has never been investigated in detail. Medical records of all Caucasian children circumcised over a 6-year period were reviewed. The excised skin underwent histological examination for BXO. Children with histological diagnosis of BXO were classified as group A, whereas children without histological diagnosis of BXO were classified as group B. The Fitzpatrick phototype (FT) was obtained in all children performing a personal or family interview with regards to their sunburn and suntan experience. According to their FT, both group A and B patients were divided into two subgroups: FT 1-2, with a higher tendency to sunburn due to their low skin melanin content; and FT 3-4 with a higher tendency to tan due to their higher skin melanin content. Maneuvers of mechanical reduction of the foreskin (MRF) performed at least 5-10 times per month during the year preceding circumcision was also considered. Statistical analysis was performed using univariate and multivariate analysis. A total of 297 patients met the inclusion criteria of our study: 78 patients were classified as group A and 219 as group B. The risk of developing BXO was significantly greater in FT 1-2 patients (n=76) (odd ratio=0.232, 95% confidence interval=0.124-0.435, pBXO (odds ratio= 5.344, 95% confidence interval=2.860-9.987, pBXO in circumcised individuals. Moreover, the data produced suggest should the advantages of repeated MRF be weighed against the increased risk of developing BXO, which in turn may increase complication rate of circumcision surgery.

  19. Efficacy of bosentan in patients with refractory thromboangiitis obliterans (Buerger disease)

    Science.gov (United States)

    Narváez, Javier; García-Gómez, Carmen; Álvarez, Lorenzo; Santo, Pilar; Aparicio, María; Pascual, María; López de Recalde, Mercè; Borrell, Helena; Nolla, Joan M.

    2016-01-01

    Abstract The cornerstone of therapy in thromboangiitis obliterans (TAO) is complete abstinence from tobacco. In addition to discontinuation of cigarette smoking, very few pharmacological and surgical options of controversial efficacy are available to date. New therapeutic options with greater efficacy are clearly needed to properly manage these patients. In this preliminary study, we assessed the effectiveness and safety of bosentan in a case series of 8 adults with TAO and severe ischemic ulceronecrotic lesions who were treated with bosentan after inadequate response to platelet inhibitors, vasodilators, and intravenous alprostadil. Additionally, we reviewed 18 well-documented patients with refractory TAO treated with bosentan, which was previously reported (PubMed 1965–2015). These 26 patients formed the basis of our present analysis. All were current smokers. The median duration of bosentan treatment (SD) was 4.5 ± 4 months (range 3–16). Eleven patients (42%) were unable to completely abstain from smoking during their follow-up. With bosentan treatment, no new ischemic lesions were observed in the target extremities. A complete therapeutic response was achieved in 80% of patients, whereas a partial response was observed in 12%. Two patients (8%) ultimately required amputation despite treatment. After discontinuation of bosentan, patients were followed for a median of 20 ± 14 months (range 3–60). Two patients whose trophic lesions had healed relapsed. When comparing patients who gave up smoking with those who were unable to completely abstain from smoking during follow-up, no significant differences were found in efficacy outcomes. Four patients (15%) developed adverse events, requiring bosentan discontinuation in 1 case. These preliminary data suggest that bosentan may be considered a therapeutic option for treatment of cases of severe TAO refractory to conventional treatment, and merit further evaluation in larger controlled, randomized clinical

  20. Human cytomegalovirus infection leads to elevated levels of transplant arteriosclerosis in a humanized mouse aortic xenograft model.

    Science.gov (United States)

    Abele-Ohl, S; Leis, M; Wollin, M; Mahmoudian, S; Hoffmann, J; Müller, R; Heim, C; Spriewald, B M; Weyand, M; Stamminger, T; Ensminger, S M

    2012-07-01

    Recent findings emphasized an important role of human cytomegalovirus (HCMV) infection in the development of transplant arteriosclerosis. Therefore, the aim of this study was to develop a human peripheral blood lymphocyte (hu-PBL)/Rag-2(-/-) γc(-/-) mouse-xenograft-model to investigate both immunological as well as viral effector mechanisms in the progression of transplant arteriosclerosis. For this, sidebranches from the internal mammary artery were recovered during coronary artery bypass graft surgery, tissue-typed and infected with HCMV. Then, size-matched sidebranches were implanted into the infrarenal aorta of Rag-2(-/-) γc(-/-) mice. The animals were reconstituted with human peripheral blood mononuclear cells (PBMCs) 7 days after transplantation. HCMV-infection was confirmed by Taqman-PCR and immunofluorescence analyses. Arterial grafts were analyzed by histology on day 40 after transplantation. PBMC-reconstituted Rag-2(-/-) γc(-/-) animals showed splenic chimerism levels ranging from 1-16% human cells. After reconstitution, Rag-2(-/-) γc(-/-) mice developed human leukocyte infiltrates in their grafts and vascular lesions that were significantly elevated after infection. Cellular infiltration revealed significantly increased ICAM-1 and PDGF-R-β expression after HCMV-infection of the graft. Arterial grafts from unreconstituted Rag-2(-/-) γc(-/-) recipients showed no vascular lesions. These data demonstrate a causative relationship between HCMV-infection as an isolated risk factor and the development of transplant-arteriosclerosis in a humanized mouse arterial-transplant-model possibly by elevated ICAM-1 and PDGF-R-β expression.

  1. Bronchiolitis obliterans organising pneumonia. A report of 11 cases and a review of the literature.

    Science.gov (United States)

    Lamont, J; Verbeken, E; Verschakelen, J; Demedts, M

    1998-10-01

    The clinical syndrome "Bronchiolitis Obliterans Organising Pneumonia" (BOOP) has to be considered in patients with a flu-like illness since some weeks, fine crackles, and on chest X-ray bilateral patchy infiltrates. There is no response to antibiotics. BOOP is essentially idiopathic, but associations to other conditions exist. Lung function is often restrictive; biochemistry is not pathognomonic. BAL shows a mixed cellular pattern. The gold standard for pathologic diagnosis is open or thoracoscopic lung biopsy. However, a BOOP pattern or reaction is often seen on histologic specimens without the clinical-radiologic features of the BOOP-entity. Therapy consists of corticosteroids, which have to be prescribed for a long time at a rather high dose. Recurrence is frequent, but prognosis is good. Evolution to respiratory insufficiency and death is rare and may occur in rapidly progressive BOOP. This study reports on 11 cases (6 males/5 females) of clinical-pathological BOOP-syndrome (mean age 58 yrs, range 17-73 yrs), with an unexpectedly high mortality rate of 36% (4 cases). The disease was idiopathic in 7, and was associated with intake of amiodarone (in 1), with past Mycoplasma pneumonia (in 1) and with connective tissue disease (in 2). There was a history of a flu-like syndrome, cough and dyspnea of a mean duration of 4 months (range 1 week to 8 months). Lung function was mostly restrictive or/and obstructive with a diffusing capacity ranging between 47 and 95% predicted; there was hypoxia in about half of the patients. Chest X-ray and computed tomography (CT) scan showed a patchy consolidation with linear opacities (unilateral in 4 patients, bilateral in 5) and/or a ground glass pattern (in 4 patients), and a focal pseudo-tumoral lesion (in 1). Bronchoalveolar lavage showed a variable pattern of mixed, or eosinophilic or neutrophilic alveolitis. Histologic diagnosis was based on open lung biopsy (in 3), on thoracoscopic biopsy (in 2), on transbronchial biopsy (in 2

  2. Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects.

    Science.gov (United States)

    Satoh, Hiroki; Fujii, Satoshi; Tsutsui, Hiroyuki

    2015-01-01

    Depression often coexists with hypertension and various cardiovascular diseases. However, the relationship between depression and the development of arteriosclerosis has not been fully established. We assessed depression and brachial-ankle pulse wave velocity (baPWV) in 828 middle-aged Japanese male subjects at baseline and during 3 years of follow-up. Depression was assessed using Center for Epidemiological Studies-Depression questionnaires, and the study subjects were divided into the following three groups: persistent depression, transient depression and no depression. The number (%) of subjects with persistent, transient and no depression were 104 (12.6), 76 (9.2) and 648 (78.2), respectively. Blood pressure and baPWV did not differ among the three groups at baseline. The changes in the baPWV values (⊿baPWV) correlated significantly and positively with age, body mass index, baseline systolic blood pressure and persistent depression (r = 0.32, P arteriosclerosis in middle-aged Japanese male subjects.

  3. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease: Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy

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    Ignacio López de Maturana

    2013-01-01

    Full Text Available Thromboangiitis obliterans (TAO or Buerger's disease is associated with both distal ulcers in the extremities and the possibility of amputation. The only treatment that has been shown to be effective in TAO is complete abstention from smoking. In spite of this, the disease progresses in up to 30 percent of cases and finally results in limb amputation. Only a few pharmacological and surgical options are available to date to improve healing ulcers in TAO. The efficacy of prostaglandin analogues is controversial. This paper summarizes the current evidence for medical treatment with bosentan in chronic ulcers in TAO patients. These available data up to date allow us to conclude that the beneficial effects of bosentan on improving endothelial function, inflammatory processes, and selective vasodilatation of damaged vessels result in a clinical enhancement regarding healing and preventive digital ulcers in such patients. In any case, these promising findings have to be confirmed with larger randomised trials.

  4. Bronchiolitis Obliterans Organizing Pneumonia as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case Report and Literature Review

    Science.gov (United States)

    Wang, Hung-Ping; Chen, Chun-Ming; Chen, Yih-Yuan; Chen, Wei

    2016-01-01

    The etiology of bronchiolitis obliterans organizing pneumonia (BOOP) remains controversial. While it has been reportedly associated with several connective tissue disorders, there are only rare reports of BOOP associated with systemic lupus erythematosus (SLE). Herein, we report a 56-year-old female patient who presented with dyspnea on exertion, cough, fever, and joint pain of her left wrist and fingers as initial symptoms. Laboratory tests revealed positivity for anti-nuclear antibody, anti-Ro, and anti-double strand DNA antibody. In this case, the patient with SLE had respiratory illness as the initial symptom due to BOOP in the absence of clear etiology. The diagnosis of BOOP was confirmed by thoracic surgery biopsy. Her respiratory symptoms and radiologic findings significantly improved following prednisolone treatment. PMID:27200095

  5. Migratory pneumonitis similar to bronchiolitis obliterans organizing pneumonia after conservative treatment of breast cancer. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Matsuura, Kanji; Hirokawa, Yutaka; Matsuura, Akiko; Akagi, Yukio; Ito, Katsuhide [Hiroshima Univ. (Japan). School of Medicine

    1999-07-01

    We report the case of a 63-year-old woman who developed cough and fever with migratory lung infiltrates three months after completion of right breast irradiation following conservative surgery. Lung infiltrates were initially localized in the irradiated area, but later spread to unirradiated areas in both lungs. No cause of migratory pneumonitis other than irradiation was found, and we clinically diagnosed this case as radiation-induced migratory pneumonitis similar to Bronchiolitis Obliterans Organizing Pneumonia(BOOP), without lung biopsy. Steroid therapy resulted incomplete resolution of lung infiltrates. The reported case clearly differed from typical radiation pneumonitis. We suggest that lung irradiation might trigger the development of migratory pneumonitis with a clinical pattern similar to that of BOOP. (author)

  6. Treatment of urethral strictures in balanitis xerotica obliterans (BXO using circular buccal mucosal meatoplasy: Experience of 15 cases

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    Abdulmuttalip Simsek

    2014-03-01

    Full Text Available Objectives: Balanitis xerotica obliterans (BXO related strictures involving the external urethral meatus. We reviewed our result with the use of circular mucosal graft in the reconstruction of strictures. Methods: Between March 1997 and January 2012, 15 patients underwent circular buccal mucosal urethroplasy for BXO related anterior urethral strictures. Urethral catheter was removed within 2 weeks. Follow-up included patient symptoms assessment, cosmetic outcome and uroflowmetry. Results: Median follow-up was 20.5 months (range 4 to 96. Mean postoperative peak urinary flow rate obtained 1 month after catheter removal was 22.4 ml per second. All patients had a normal meatus and none had recurrent stricture, chordee or erectile dysfunction. A functional and cosmetic outcome was achieved in 100% of the patients. Conclusions: Circular mucosal graft technique for treatment of meatal strictures is an efficient method for the restoration of a functional and cosmetic penis.

  7. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression.

    Science.gov (United States)

    He, Yunqiang; Xia, Peng; Jin, Hao; Zhang, Yan; Chen, Bicheng; Xu, Ziqiang

    2016-01-01

    Objective. Transplant arteriosclerosis is considered one of the major factors affecting the survival time of grafts after organ transplantation. In this study, we proposed a hypothesis of whether lycopene can protect grafted vessels through regulating key proteins expression involved in arteriosclerosis. Methods. Allogeneic aortic transplantation was performed using Brow-Norway rats as donors and Lewis rats as recipients. After transplantation, the recipients were divided into two groups: the allograft group and the lycopene group. Negative control rats (isograft group) were also established. Histopathological staining was performed to observe the pathological changes, and the expression levels of Ki-67, caspase-3, Rho-associated kinases, intercellular adhesion molecules (ICAM-1), and eNOS were assessed. Western blotting analysis and real-time PCR were also performed for quantitative analysis. Results. The histopathological staining showed that vascular stenosis and intimal thickening were not evident after lycopene treatment. The Ki-67, ROCK1, ROCK2, and ICAM-1 expression levels were significantly decreased. However, eNOS expression in grafted arteries and plasma cGMP concentration were increased after lycopene treatment. Conclusions. Lycopene could alleviate vascular arteriosclerosis in allograft transplantation via downregulating Rho-associated kinases and regulating key factor expression through the NO/cGMP pathways, which may provide a potentially effective method for transplant arteriosclerosis in clinical organ transplantation.

  8. Blood pressure in young adults with and without a paternal history of premature coronary heart disease in Europe: the EARS study. [European arteriosclerosis study

    NARCIS (Netherlands)

    Masana, L.; Farinaro, E.; Henauw, S. de; Nicaud, V.

    1996-01-01

    Objective : The European Arteriosclerosis Study (EARS) was designed to identify variables which discriminate subjects with a paternal history of premature coronary heart disease (CHD) from controls and to study the distribution of these variables across Europe. In this article we report on the blood

  9. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression

    Science.gov (United States)

    Xia, Peng; Jin, Hao; Zhang, Yan

    2016-01-01

    Objective. Transplant arteriosclerosis is considered one of the major factors affecting the survival time of grafts after organ transplantation. In this study, we proposed a hypothesis of whether lycopene can protect grafted vessels through regulating key proteins expression involved in arteriosclerosis. Methods. Allogeneic aortic transplantation was performed using Brow-Norway rats as donors and Lewis rats as recipients. After transplantation, the recipients were divided into two groups: the allograft group and the lycopene group. Negative control rats (isograft group) were also established. Histopathological staining was performed to observe the pathological changes, and the expression levels of Ki-67, caspase-3, Rho-associated kinases, intercellular adhesion molecules (ICAM-1), and eNOS were assessed. Western blotting analysis and real-time PCR were also performed for quantitative analysis. Results. The histopathological staining showed that vascular stenosis and intimal thickening were not evident after lycopene treatment. The Ki-67, ROCK1, ROCK2, and ICAM-1 expression levels were significantly decreased. However, eNOS expression in grafted arteries and plasma cGMP concentration were increased after lycopene treatment. Conclusions. Lycopene could alleviate vascular arteriosclerosis in allograft transplantation via downregulating Rho-associated kinases and regulating key factor expression through the NO/cGMP pathways, which may provide a potentially effective method for transplant arteriosclerosis in clinical organ transplantation. PMID:28050227

  10. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression

    Directory of Open Access Journals (Sweden)

    Yunqiang He

    2016-01-01

    Full Text Available Objective. Transplant arteriosclerosis is considered one of the major factors affecting the survival time of grafts after organ transplantation. In this study, we proposed a hypothesis of whether lycopene can protect grafted vessels through regulating key proteins expression involved in arteriosclerosis. Methods. Allogeneic aortic transplantation was performed using Brow-Norway rats as donors and Lewis rats as recipients. After transplantation, the recipients were divided into two groups: the allograft group and the lycopene group. Negative control rats (isograft group were also established. Histopathological staining was performed to observe the pathological changes, and the expression levels of Ki-67, caspase-3, Rho-associated kinases, intercellular adhesion molecules (ICAM-1, and eNOS were assessed. Western blotting analysis and real-time PCR were also performed for quantitative analysis. Results. The histopathological staining showed that vascular stenosis and intimal thickening were not evident after lycopene treatment. The Ki-67, ROCK1, ROCK2, and ICAM-1 expression levels were significantly decreased. However, eNOS expression in grafted arteries and plasma cGMP concentration were increased after lycopene treatment. Conclusions. Lycopene could alleviate vascular arteriosclerosis in allograft transplantation via downregulating Rho-associated kinases and regulating key factor expression through the NO/cGMP pathways, which may provide a potentially effective method for transplant arteriosclerosis in clinical organ transplantation.

  11. Bronquiolitis obliterante con neumonía organizada y enfermedad de Crohn Bronchiolitis obliterans organizing pneumonia and Crohn’s disease

    Directory of Open Access Journals (Sweden)

    P. Gil-Simón

    2008-03-01

    Full Text Available Las manifestaciones extraintestinales respiratorias en la enfermedad inflamatoria intestinal (EII son excepcionales. Presentamos un caso de bronquiolitis obliterante con neumonía organizada (BONO en paciente con enfermedad de Crohn, en remisión clínica sin tratamientos farmacológicos.Extraintestinal respiratory manifestations in inflammatory bowel disease (IBD are rare. We present a case of bronchiolitis obliterans organizing pneumonia (BOOP in a patient with Crohn's disease, with clinical remission with no drug therapy.

  12. 儿童感染后闭塞性细支气管炎研究进展%Post-infectious bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    吴小英

    2012-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种由严重小气道炎症损伤引起的少见的慢性气道阻塞性肺疾病.BO常见病因有感染、心肺或骨髓移植、吸入有毒物质、胃食管反流、结缔组织病及药物性等.儿童以感染后BO(post-infectious bronchiolitis obliterans,PIBO)最常见.文章综述PIBO研究进展.%Bronchiolitis obliterans (BO) is a rare form of chronic obstructive lung disease that follows a severe inflammatory insult to the small airways. The common etiologies of BO include infection, transplantations of the lung, the heart or the bone-marrow, toxic inhalation, gastroesophageal reflux, connective tissue disorders, drugs and so on. In children, post-infectious BO (PIBO) is the most common form. This article reviews the recent progress of PIBO in children.

  13. The Origin of Neointimal Smooth Muscle Cells in Transplant Arteriosclerosis from Recipient Bone-marrow Cells in Rat Aortic Allograft

    Institute of Scientific and Technical Information of China (English)

    SONG Zifang; LI Wei; ZHENG Qichang; SHANG Dan; SHU Xiaogang; GUAN Siming

    2007-01-01

    In order to investigate the origin of neointimal smooth muscle cells in transplant arteriosclerosis in rat aortic allograft, sex-mismatched bone marrow transplantation was performed from male Wistar rats to female Wistar rats. Four weeks after transplantation, the aortic transplant model was established by means of micro-surgery in rats. The recipients were divided into 4 groups: female Wistar-female Wistar aortic isografts, female SD-female Wistar aortic allografts, male SD-male Wistar aortic allografts, female SD-chimera Wistar aortic allografts. Eight weeks after transplantation, aortic grafts were removed at autopsy and processed for histological evaluation and immunohistochemistry. The results indicated that excessive accumulation of α-SMA-positive smooth muscle cells resulted in significant neointima formation and vascular lumen stricture in rat aortic allografts.Neointima assay revealed that the neointimal area and NIA/MA ratio of transplanted artery were significantly increased in all of aortic allograft groups as compared with those in aortic isograft group (P<0.01). Neointimal smooth muscle cells were harvested from cryostat sections of aortic allograft by microdissection method. The Sry gene-specific PCR was performed, and the result showed that a distinct DNA band of 225 bp emerged in the male-male aortic allograft group and chimera aortic allograft group respectively, but not in the female-female aortic allograft group. It was suggested that recipient bone-marrow cells, as the origin of neointimal smooth muscle cells, contributed to the pathological neointimal hyperplasia of aortic allograft and transplant arteriosclerosis.

  14. Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis.

    Science.gov (United States)

    Nicolle, A P; Carlos Sampedrano, C; Fontaine, J J; Tessier-Vetzel, D; Goumi, V; Pelligand, L; Pouchelon, J-L; Chetboul, V

    2005-03-01

    A 12-year-old sexually intact male Vendee Griffon Basset was presented for acute pulmonary oedema. Severe systemic systolic arterial hypertension (SAH) was diagnosed (290 mmHg). Despite blood and abdominal ultrasound tests, the underlying cause of the systemic hypertension could not be determined, and primary SAH was therefore suspected. Conventional echocardiography showed eccentric left ventricular hypertrophy with normal fractional shortening. Despite this apparent normal systolic function, 2D colour tissue Doppler imaging (TDI) identified a marked longitudinal systolic left ventricular myocardial alteration, whereas radial function was still preserved. Three months later, the dog underwent euthanasia because of an acute episode of distal aortic thromboembolism. Necropsy revealed severe aortic and iliac arteriosclerosis. SAH related to arteriosclerosis is a common finding in humans, but has not been previously described in dogs. Moreover, its consequence on longitudinal myocardial function using TDI has never been documented before in this species.

  15. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Gi [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Ajou University Medical Center, Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of); Shin, Hyun Joo; Kim, Myung-Joon; Lee, Mi-Jung [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Kim, Yoon Hee; Sohn, Myung Hyun; Kim, Kyung Won [Yonsei University College of Medicine, Department of Pediatrics and Institute of Allergy, Severance Children' s Hospital, Seoul (Korea, Republic of); Lyu, Chuhl Joo [Yonsei University College of Medicine, Department of Pediatric Hematology and Oncology, Severance Children' s Hospital, Seoul (Korea, Republic of)

    2015-10-15

    To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. (orig.)

  16. Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells.

    Directory of Open Access Journals (Sweden)

    Aric L Gregson

    Full Text Available Bronchiolitis obliterans syndrome (BOS is the major obstacle to long-term survival after lung transplantation, yet markers for early detection and intervention are currently lacking. Given the role of regulatory T cells (Treg in modulation of immunity, we hypothesized that frequencies of Treg in bronchoalveolar lavage fluid (BALF after lung transplantation would predict subsequent development of BOS. Seventy BALF specimens obtained from 47 lung transplant recipients were analyzed for Treg lymphocyte subsets by flow cytometry, in parallel with ELISA measurements of chemokines. Allograft biopsy tissue was stained for chemokines of interest. Treg were essentially all CD45RA(-, and total Treg frequency did not correlate to BOS outcome. The majority of Treg were CCR4(+ and CD103(- and neither of these subsets correlated to risk for BOS. In contrast, higher percentages of CCR7(+ Treg correlated to reduced risk of BOS. Additionally, the CCR7 ligand CCL21 correlated with CCR7(+ Treg frequency and inversely with BOS. Higher frequencies of CCR7(+ CD3(+CD4(+CD25(hiFoxp3(+CD45RA(- lymphocytes in lung allografts is associated with protection against subsequent development of BOS, suggesting that this subset of putative Treg may down-modulate alloimmunity. CCL21 may be pivotal for the recruitment of this distinct subset to the lung allograft and thereby decrease the risk for chronic rejection.

  17. ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

    Directory of Open Access Journals (Sweden)

    V. Z. Krivitskaya

    2015-01-01

    Full Text Available Exacerbation of bronchial asthma (BA and common deterioration of health during chronic bronchiolitis obliterans (ChBO are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50% in patients with BA. Influenza A(H1N1pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1pdm09 (63% of seroconversions. There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1 pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity. 

  18. Managing bronchiolitis obliterans syndrome (BOS) and chronic lung allograft dysfunction (CLAD) in children: what does the future hold?

    Science.gov (United States)

    Snell, Gregory I; Paraskeva, Miranda; Westall, Glen P

    2013-08-01

    The success of pediatric lung transplantation continues to be limited by long-term graft dysfunction. Historically this has been characterized as an obstructive spirometric defect in the form of the bronchiolitis obliterans syndrome (BOS). It is recognized, however, that this does not reflect many of the other acknowledged etiologies of chronic lung dysfunction-noting it is the sum of the parts that contribute to respiratory morbidity and mortality after transplant. The term chronic lung allograft dysfunction (CLAD) has been coined to reflect these other entities and, in particular, a group of relatively recently described lung disorders called the restrictive allograft syndrome (RAS). RAS is characterized by a restrictive spirometric defect. Although these entities have not yet been studied in a pediatric setting their association with poor compliance, antibody-mediated rejection (AMR), and post-infectious lung damage (particularly viral) warrants attention by pediatric lung transplant teams. Current therapy for the BOS subset of CLAD is otherwise limited to changing immunosuppressants and avoiding excessive infectious risk by avoiding over-immunosuppression. Long-term macrolide therapy in lung transplantation is not of proven efficacy. Reviewing previous BOS studies to explore restrictive spirometric cases and joint projects via groups like the International Pediatric Lung Transplant Collaborative will be the way forward to solve this pressing problem.

  19. Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost.

    Science.gov (United States)

    Melillo, Elio; Grigoratos, Chrysanthos; Sanctis, Francesco De; Spontoni, Paolo; Nuti, Marco; Dell'Omodarme, Matteo; Ferrari, Mauro; Balbarini, Alberto

    2015-07-01

    We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPo 2) and carbon dioxide (TcPco 2) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44°C (P < .005). Forefoot maximal hyperemic test at 44°C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

  20. Composition of the inflammatory infiltrate in pediatric penile lichen sclerosus et atrophicus (balanitis xerotica obliterans): a prospective, comparative immunophenotyping study.

    Science.gov (United States)

    Hinchliffe, S A; Ciftci, A O; Khine, M M; Rickwood, A M; Ashwood, J; McGill, F; Clapham, E M; van Velzen, D

    1994-01-01

    Dermatopathological evaluation of pediatric preputial inflammatory disease rarely allows for specific diagnosis other than pediatric penile lichen sclerosus et atrophicus (balanitis xerotica obliterans, LSA/BXO). A prospective immunopathological study was performed on 20 consecutive, unselected, clinically and histopathologically confirmed LSA/BXO cases to determine the relative presence of T and B lymphocytes. There were seven cases with early stages of disease, eight with florid disease, and five with later stages of disease. Two ritual circumcision specimens and 12 specimens with non-LSA/BXO balanitis, collected during the same period, were used as controls. The infiltrate in LSA/BXO patients was wholly composed of T cells (positive with UCLH-1 antibody) in all cases. B cells (positive with L-26 antibody) were found only focally in small, discreet, easily recognizable (follicular or early follicle-like) aggregates, positioned slightly deeper than the band-like infiltrate of T cells. T cells were inconspicuous in 9 of the 12 control specimens. In the three other controls, T cells were much more obvious and these patients showed clinical features possibly suggestive of LSA/BXO in early, prediagnosable phases of development. We conclude that limited immunophenotyping may be a useful adjunct to diagnosis in pediatric cases in which only limited tissue is available or the disease may be more difficult to classify with confidence.

  1. Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer.

    Science.gov (United States)

    Al-Hameed, Fahad M

    2015-06-01

    A 62-year-old woman underwent a right mastectomy with axillary node dissection for a poorly differentiated ductal carcinoma. One month later, she underwent a left nephrectomy for a renal cell carcinoma. Two weeks after, she received her first cycle of cyclophosphamide, methotrexate, and 5FU (CMF) as a part of her breast cancer treatment. We describe an unusual case of non-occlusive saddle pulmonary embolus with extensive bilateral deep vein thrombosis and severe bronchiolitis obliterans with organizing pneumonia developing simultaneously after the first CMF chemotherapy for breast cancer.

  2. Endothelial Cell Apoptosis Induces TGF-β Signaling-Dependent Host Endothelial-Mesenchymal Transition to Promote Transplant Arteriosclerosis.

    Science.gov (United States)

    Li, J; Xiong, J; Yang, B; Zhou, Q; Wu, Y; Luo, H; Zhou, H; Liu, N; Li, Y; Song, Z; Zheng, Q

    2015-12-01

    Endothelial cells (ECs) apoptosis is an initial event in transplant arteriosclerosis (TA), resulting in allograft function loss. To elucidate the precise mechanisms of ECs apoptosis leading to neointimal smooth muscle cells (SMCs) accumulation during TA. We induced apoptosis in cultured ECs by overexpressing p53 through lentivirus-mediated transfection. ECs apoptosis induced the production of transforming growth factor (TGF)-β1 in both apoptotic and neighboring viable cells, leading to increased TGF-β1 in the culture media. Conditioned media from Ltv-p53-transfected ECs further promoted transition of cultured ECs to SM-like cells by activating TGF-β/Smad3, PI3K/Akt/mTOR, and MAPK/ERK signaling in a TGF-β-dependent manner. In transgenic rat aorta transplantation models, inhibition of ECs apoptosis in Bcl-xL(+/+) knock-in rat aortic allografts significantly reduced TGF-β1 production both in allograft endothelia and in blood plasma, which in turn decreased accumulation of SM22α+ cells from transgenic recipient ECs originally marked with EGFP knock-in in neointima and alleviated TA. Systemic treatment with SIS3, AP23573, or PD98059 also prevented recipient ECs-originated SM-like cells accumulation and intima hyperplasia in aortic allografts. These data suggest that allograft EC apoptosis induced recipient endothelial-mesenchymal (smooth muscle) transition via TGF-β signaling, resulting in recipient EC-derived SMC accumulation as a major mechanism of vascular remodeling during TA.

  3. A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

    Directory of Open Access Journals (Sweden)

    Kastelijn Elisabeth A

    2011-11-01

    Full Text Available Abstract Background Caveolin 1 (Cav-1 is the primary structural component of cell membrane invaginations called 'caveolae'. Expression of Cav-1 is implicated in the pathogenesis of pulmonary fibrosis. Genetic polymorphisms in the CAV1 gene influence the function of Cav-1 in malignancies and associate with renal allograft fibrosis. Chronic allograft rejection after lung transplantation, called 'bronchiolitis obliterans syndrome' (BOS, is also characterised by the development of fibrosis. In this study, we investigated whether CAV1 genotypes associate with BOS and whether Cav-1 serum levels are influenced by the CAV1 genotype and can be used as a biomarker to predict the development of BOS. Methods Twenty lung transplant recipients with BOS (BOSpos, ninety without BOS (BOSneg and four hundred twenty-two healthy individuals donated DNA samples. Four SNPs in CAV1 were genotyped. Serial Cav-1 serum levels were measured in a matched cohort of 10 BOSpos patients and 10 BOSneg patients. Furthermore, single-time point Cav-1 serum levels were measured in 33 unmatched BOSneg patients and 60 healthy controls. Results Homozygosity of the minor allele of rs3807989 was associated with an increased risk for BOS (odds ratio: 6.13; P = 0.0013. The median Cav-1 serum level was significantly higher in the BOSpos patients than in the matched BOSneg patients (P = 0.026. Longitudinal analysis did not show changes in Cav-1 serum levels over time in both groups. The median Cav-1 serum level in the group of 43 BOSneg patients was lower than that in the healthy control group (P = 0.046. In lung transplant recipients, homozygosity of the minor allele of rs3807989 and rs3807994 was associated with increased Cav-1 serum levels. Conclusion In lung transplant recipients, the CAV1 SNP rs3807989 was associated with the development of BOS and Cav-1 serum levels were influenced by the CAV1 genotype.

  4. 闭塞性干燥性龟头炎研究进展%Balanitis xerotica obliterans

    Institute of Scientific and Technical Information of China (English)

    张堂德; 邓俐

    2010-01-01

    闭塞性干燥性龟头炎是一种病因不明的慢性萎缩性皮肤黏膜疾病,通常主要累及男女生殖器与前尿道的表皮和真皮结缔组织.临床上特征性损害是侵及包皮和阴茎的白色丘疹和斑片,可导致包皮变硬,继发性包茎及尿道口狭窄.发生在阴茎龟头的硬化萎缩性苔藓又称闭塞性干燥性龟头炎.对闭塞性干燥性龟头炎的病因、发病机制、临床表现、组织病理及治疗等方面的进展概述.%Balanitis xerotiea obliterans (BXO) is a chronic atrophic mucocutaneous disorder of unknown etiology.It mainly affects the epidermis and dermal connective tissue of genital and anterior urethral skin of both males and females.Clinically.it is characterized by white papules or plaques on the foreskin and penis that may result in the stiffening of prepuce followed by phimosis and meatal stenosis.Lichen sclerosus is a term used as a synonym for BXO of the glans penis.This paper offers an update on the knowledge about the etiology,pathogenesis,clinical manifestations,histopathology and treatment of BXO.

  5. G-protein coupled receptor auto-antibodies in thromboangiitis obliterans (Buerger's disease) and their removal by immunoadsorption.

    Science.gov (United States)

    Klein-Weigel, Peter F; Bimmler, Marion; Hempel, Petra; Schöpp, Sebastian; Dreusicke, Siegrid; Valerius, Jana; Bohlen, Anne; Boehnlein, Joana M; Bestler, Daniel; Funk, Stephanie; Elitok, Saban

    2014-09-01

    Hintergrund: Histopathologische und serologische Befunde sprechen für eine Immunpathogenese der Thromboangiitis obliterans (TAO, Buerger’sche Erkrankung). Autoantikörper scheinen eine wichtige Rolle im Krankheitsgeschehen zu spielen. Es wurden wiederholt positive therapeutische Effekte durch eine Immunadsorption (IA) gezeigt. Wir analysierten agonistische Autoantikörper (agAAK), die gegen G-Protein gekoppelte Rezeptoren (GPCR) gerichtet sind und analysierten, ob diese durch eine IA effektiv beseitigt werden können. Patienten und Methoden: Zwischen Dezember 2012 und Mai 2014 wurden 11 Patienten mittels IA über 5 konsekutive Tage behandelt. Die agAAK wurden unter Verwendung spezifischer ELISA-Techniken bestimmt. Ergebnisse: AgAAK wurden bei 9 von 11 Patienten (81.8 %) gefunden. Multiple agAAK waren bei 7 Patienten (63.6 %) nachweisbar. Darüber hinaus wurde ein agAAK-Cluster entdeckt, das sich gegen Loop1 des adrenergen α1-Rezeptors und Loop1 des Endothelin A (ETA)-Rezeptors richtet, und sich bei 72.7 % respektive 54.5 % der TAO-Patienten nachweisen ließ. AgAAK gegen Epitop 1 oder 2 des Angiotensin-1-Rezeptors wurden bei 3 Patienten, agAAK gegen Loop1/2 des Proteinase-aktivierten Rezeptor (PAR) wurden bei 2 Patienten nachgewiesen. AgAAK gegen den ETA-Rezeptor traten niemals ohne gleichzeitigen Nachweis von agAAK gegen den α1-adrenergen Rezeptor auf und waren immer gegen Loop1 gerichtet. Unmittelbar nach Beendigung der IA ließen sich bei 81.8 % aller Patienten und bei 77.8 % aller Fälle mit positiven agAAK vor der IA keine agAAK mehr nachgewiesen. Schlussfolgerungen: Wir konnten bei Patienten mit aktiver TAO agAAK gegen GPCR und darüber hinaus ein Antikörper-Cluster nachweisen, das sich bevorzugt gegen Loop1 des α-1-adrenergen Rezeptors und Loop1 des ETA-Rezeptors richtet. Die agAAK wurden mehrheitlich erfolgreich durch die IA eliminiert. Wir sind der Auffassung, dass gegen GPCR-gerichtete agAAK eine wichtige Rolle in der Pathogenese der TAO spielen und

  6. Arteriosclerosis: facts and fancy.

    Science.gov (United States)

    Fishbein, Michael C; Fishbein, Gregory A

    2015-01-01

    Arterial vascular diseases comprise the leading cause of death in the industrialized world. Every physician learns about the pathology of these diseases in medical school. All pathologists evaluate arterial disease in surgical pathology and/or autopsy specimens. All clinicians encounter patients with clinical manifestations of these diseases. With such a common and clinically-important group of entities one would think there would be a general understanding of the "known" information that exists. That is, physicians and scientists should be able to separate what is fact and what is fancy. This review article is intended to generate thought in this regard.

  7. [Arteriosclerosis--selected aspects].

    Science.gov (United States)

    Kucharska, Ewa

    2014-01-01

    The article summarizes the current knowledge concerning the diagnosis of atherosclerosis and therapeutic objectives. Atherosclerosis is one of the most common medical problems. It affects adults as well as children. It leads to clinically overt cardiovascular diseases (CVD), which are the cause of premature deaths. During its course, the formation of atherosclerotic plaque takes place, along with local inflammations artery walls. Gradually growing plaque does not cause clinical symptoms until the stenosis does not exceed 70-80% of the coronary vessel diameter, causing a marked reduction in blood flow to the heart muscle. The prevention of atherosclerosis and its complications requires an individual assessment of cardiovascular risk. In people without CVD symptoms, it is recommended to use SCORE risk card for Polish population, assessing the 10-year risk of cardiac death. A key element in combating atherosclerosis is to eliminate its risk factors by both implementing pro-health policies, as well as working with individual patients. An important objective is the proper control of blood pressure. It should not exceed 140/90 mmHg. A very important role is played by correct approach to patients with moderate or unusual cardiovascular risk. Despite knowing many facts about the mechanisms of atherosclerosis and its treatment, many issues still remain to be clarified. Finding methods to influence ongoing immune processes within arteries is of particular interest, which will soon make way to new therapeutic possibilities.

  8. 下肢动脉硬化闭塞症患者股动脉粥样硬化斑块中巨噬细胞极化表型与自噬信号相关性的研究%Correlation between autophagy and polarization of macrophages in atherosclerosis plaque in arteriosclerosis obliterans amputees

    Institute of Scientific and Technical Information of China (English)

    陈文娜; 郭胜男; 王俊岩; 贾连群; 李大勇; 田英

    2016-01-01

    本文探讨了下肢动脉硬化闭塞症患者股动脉粥样硬化斑块中巨噬细胞自噬与极化的相互联系.取下肢动脉硬化闭塞症截肢患者的股动脉标本,分别行HE (hematoxylin and eosin)、油红O和免疫荧光染色,观察动脉粥样硬化斑块形态、斑块内巨噬细胞表型及自噬体表达;采用实时荧光定量RT-PCR技术检测动脉组织巨噬细胞M1与M2型标记物的mRNA表达水平;采用Western blot方法检测巨噬细胞极化信号通路及自噬蛋白表达水平.结果显示,动脉标本染色可见明显脂质沉积和大量泡沫细胞及炎性细胞浸润,纤维斑块以M1型巨噬细胞为主,粥样斑块M1与M2表型同时高表达,其中M2型巨噬细胞升高尤为显著,且粥样斑块自噬水平明显高于纤维斑块.纤维斑块组织肿瘤坏死因子α(TNF-α)、单核细胞趋化因子1(MCP-1)、诱导性—氧化氮合成酶(iNOS)、白细胞介素6 (IL-6)、白细胞介素12 (IL-12) mRNA表达水平均明显高于粥样斑块组织(P<0.01或0.05),而精氨酸酶1 (Arg-1)、转化生长因子β(TGF-β)、CD163及白细胞介素10 (IL-10)表达水平明显低于粥样斑块组织(P<0.01).纤维斑块组织p-STAT1及NF-κB表达水平显著升高(P<0.01),而粥样斑块组织p-STAT6表达显著升高(P<0.01),粥样斑块组织自噬体蛋白LC3-Ⅱ表达水平明显高于纤维斑块组织(P<0.01).研究提示早期动脉粥样硬化斑块中巨噬细胞通过p-STAT1/NF-κB通路诱导向M1型极化,表达适度的自噬水平;而晚期斑块中巨噬细胞则通过激活p-STAT6通路诱导向M2型极化的过渡,M2型巨噬细胞较M1型具有更高的自噬水平.

  9. Receiver operating characteristic study on color Doppler ultrasound and three-dimensional dynamic contrast-enhanced MR angiography in arteriosclerosis obliterans below knee%彩色多普勒超声与三维动态增强MRA诊断膝以下动脉硬化性闭塞受试者操作特征曲线分析

    Institute of Scientific and Technical Information of China (English)

    强沁晨; 杜湘珂; 李建国

    2010-01-01

    目的 使用受试者操作特征(ROC)曲线分析评价彩色多普勒超声(CDU)与三维动态增强磁共振血管造影(3D DCE-MRA)对膝以下动脉硬化性闭塞的诊断价值.方法 41例小腿动脉硬化性闭塞患者,其中男性34例,女性7例:年龄48~83岁,平均年龄69.10岁.经CDU及3D DCE-MRA检查,与数字减影血管造影检查(DSA)和或手术相对照.结果 3D DCB-MRA诊断膝以下动脉硬化性闭塞、重度狭窄的Az值分别为0.7646、0.7745;CDU诊断膝以下动脉硬化性闭塞、重度狭窄的Az值分别为0.9526、0.905 3.从ROC曲线可见膝以下动脉硬化性闭塞的准确度CDU诊断优于3D DCE-MRA.结论 对于膝以下动脉硬化性闭塞的患者,CDU是简便易行且准确的检合方法,优于3D DCE-MRA.

  10. Associação de bronquiolite obliterante pós-infecciosa e hemossiderose pulmonar na infância Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood

    Directory of Open Access Journals (Sweden)

    Leonardo Araújo Pinto

    2006-12-01

    Full Text Available Descreve-se uma apresentação rara de bronquiolite obliterante associada a hemossiderose pulmonar, em paciente de nove anos com sintomas respiratórios persistentes iniciados após episódio de bronquiolite aguda grave aos sete meses. Após o episódio agudo, apresentou sintomas respiratórios persistentes, piorando significativamente aos sete anos, quando começou a apresentar dificuldade respiratória em pequenos esforços. A tomografia computadorizada de tórax demonstrou achados compatíveis com bronquiolite obliterante. A biópsia pulmonar a céu aberto demonstrou numerosos macrófagos corados com hemossiderina, além dos achados compatíveis com bronquiolite obliterante. O diagnóstico de hemossiderose pulmonar pode estar ocasionalmente associado a bronquiolite obliterante em crianças com seqüela pós-viral grave.In the present report, we describe an unusual presentation of post-infectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in a nine-year-old boy with persistent respiratory symptoms subsequent to an episode of acute bronchiolitis occurring at the age of seven months. After the episode, the persistent respiratory symptoms worsened significantly, and, by the age of seven, the patient began to have difficulty breathing after minimal exertion. Computed tomography of the chest presented findings consistent with bronchiolitis obliterans. Open lung biopsy revealed numerous hemosiderin-laden macrophages, as well as other findings consistent with bronchiolitis obliterans. Pulmonary hemosiderosis can occasionally be accompanied by bronchiolitis obliterans in children with severe sequelae after an episode of viral infection.

  11. 中老年健康体检人群眼底动脉硬化与高血压相关性分析%Correlation between classification of retinal arteriosclerosis and classification of hypertension in middle - aged and aged people

    Institute of Scientific and Technical Information of China (English)

    钱波; 张艳

    2012-01-01

    目的:了解中老年人群眼底动脉硬化分级与高血压分级的关系.方法:从2010年在华东疗养院进行健康体检的45岁及以上人群中随机抽取1827人的体检资料进行统计分析.结果:检出眼底动脉硬化753人,其中患有高血压者501人,与Ⅰ级眼底动脉硬化患者比较,Ⅱ级眼底动脉硬化患者高血压2、3级比例明显增大(2级:19.8%比31.0%,3级:14.5%比53.2%,P均<0.05).结论:高血压是眼底动脉硬化的危险因素,定期体检是发现和防治眼动脉硬化的关键.%Objective: To study correlation between classification of retinal arteriosclerosis and classification of hypertension in middle-aged and aged people. Methods: Physical examination data of 1827 peoples who were ≥45 years old and underwent physical examination in Huadong Sanatorium in 2010 were randomly selected for statistical analysis. Results: A total of 753 peoples with retinal arteriosclerosis were detected in 1827 peoples, including 501 peoples with hypertension. Compared with patients with retinal arteriosclerosis grade I , ratios of patients with hypertension stage 2 and 3 significantly increased in patients with retinal arteriosclerosis grade 1 (stage 2- 19. 8% vs. 31.0%, stage 3: 14.5% vs. 53.2%, P < 0.05 both). Conclusion: Hypertension is a risk factor for retinal arteriosclerosis. Taking physical examination regularly are keys for detection, prevention and cure of retinal arteriosclerosis.

  12. 儿童闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎一例并文献复习%Bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review

    Institute of Scientific and Technical Information of China (English)

    韩青; 史彧; 李红霞; 唐文伟; 刘红霞; 赵德育

    2016-01-01

    目的 探讨闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎儿童临床-影像-病理学特点.方法 回顾1例南京医科大学附属南京儿童医院呼吸科2012-2013年收治的肺炎支原体肺炎后合并闭塞性细支气管炎伴机化性肺炎的儿童闭塞性支气管炎患儿临床诊治情况、影像学表现、组织病理学所见,并复习相关文献.结果 10岁女童,反复咳嗽、咯黄脓痰、不规则发热1个月,左下肺呼吸音低并有管状呼吸音;肺部影像示左下肺支气管扩张、扭曲,远端肺不张.纤维支气管镜见支气管黏膜滤泡增生,左下支气管亚段以下闭塞、痰栓.肺组织切面灰红、灰黄,局灶肉质变,管腔内少量黄色分泌物;镜下见肺组织纤维结缔组织增生、见泡沫细胞及Masson小体.肺炎支原体抗体IgM>1∶160.经红霉素等抗感染,纤维支气管镜灌洗后一度改善,但因病情反复最终行左肺切除,术后恢复良好.检索1990年1月-2016年1月CNKI中文数据库及PubMed,以“闭塞性支气管炎”与“闭塞性细支气管炎伴机化性肺炎”同时检索,没有检索到国内外任何文献.结论 闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎患儿表现为发热及呼吸道症状迁延不愈,肺部呼吸音低、管状呼吸音;肺炎支原体抗体阳性.影像学表现支气管扩张、远端肺不张.病理学检查可见肺纤维结缔组织增生、Masson小体.经肺叶切除病情好转.%Objective To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP).Method The clinical manifestations,characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed.Result A 10-year-old girl complained of recurrent paroxysmal cough and episodes of

  13. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    ABSTRACT Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting ß2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. PMID:27383939

  14. The number of FoxP3+ cells in transbronchial lung allograft biopsies does not predict bronchiolitis obliterans syndrome within the first five years after transplantation

    DEFF Research Database (Denmark)

    Krustrup, Dorrit; Iversen, Martin; Martinussen, Torben;

    2015-01-01

    Background: An important limitation to the success of lung transplantation is the development of bronchiolitis obliterans syndrome (BOS). It has been hypothesized that regulatory T lymphocytes (Tregs) are related to the risk of BOS. We aim to evaluate whether the number of forkhead box P3 (FoxP3......+) cells/mm2 in lung allograft biopsies is a predictor of long-term outcome. Materials and Methods: A total of 58 consecutive lung transplant patients were included in the study. For 233 routine surveillance biopsy samples, the numbers of FoxP3+ cells/mm2 were assessed by immunohistochemical staining...... with antibodies against FoxP3. BOS scores were calculated for the first five yr after transplantation. Results: We determined that acute rejection was related to the time elapsed from transplantation to BOS with hazard ratios of 3.18 (p = 0.02) and 3.73 (p = 0.04) when comparing the levels of acute rejection...

  15. 肺移植后OB动物模型的研究进展%Progress on animal model of bronchiolitis obliterans after lung transplantation

    Institute of Scientific and Technical Information of China (English)

    康乐

    2014-01-01

    肺移植(lung transplantation,LT)已成为治疗终末期肺疾病患者生命的一个重要手段.细支气管闭塞综合征(bronchiolitis obliterans syndrome,BOS)作为LT术后的一种并发症广泛存在,其特征性病理表现为闭塞性细支气管炎(obliterative bronchiolitis,OB):细支气管周围有淋巴细胞浸润,最终导致纤维瘢痕的形成和细支气管闭塞.理想的动物模型有助于研究的进一步开展.目前,研究肺移植缺少一种理想的动物模型.了解肺移植后闭塞性细支气管炎的发病机制,有助于改善肺移植病人的生活质量,延长肺移植后患者生存率.本研究23将就肺移植后的闭塞性细支气管炎模型做一综述.

  16. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans

    Directory of Open Access Journals (Sweden)

    Cecilia Calabrese

    Full Text Available ABSTRACT Post-infectious bronchiolitis obliterans (PIBO is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting 2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance.

  17. The Impact of Alemtuzumab and Basiliximab Induction on Patient Survival and Time to Bronchiolitis Obliterans Syndrome in Double Lung Transplantation Recipients.

    Science.gov (United States)

    Furuya, Y; Jayarajan, S N; Taghavi, S; Cordova, F C; Patel, N; Shiose, A; Leotta, E; Criner, G J; Guy, T S; Wheatley, G H; Kaiser, L R; Toyoda, Y

    2016-08-01

    We examined the effect of alemtuzumab and basiliximab induction therapy on patient survival and freedom from bronchiolitis obliterans syndrome (BOS) in double lung transplantation. The United Network for Organ Sharing database was reviewed for adult double lung transplant recipients from 2006 to 2013. The primary outcome was risk-adjusted all-cause mortality. Secondary outcomes included time to BOS. There were 6117 patients were identified, of whom 738 received alemtuzumab, 2804 received basiliximab, and 2575 received no induction. Alemtuzumab recipients had higher lung allocation scores compared with basiliximab and no-induction recipients (41.4 versus 37.9 versus 40.7, p alemtuzumab and basiliximab recipients compared with patients who received no induction (2321 versus 2352 versus 1967 days, p = 0.001). Alemtuzumab (hazard ratio 0.80, 95% confidence interval 0.67-0.95, p = 0.009) and basiliximab induction (0.88, 0.80-0.98, p = 0.015) were independently associated with survival on multivariate analysis. At 5 years, alemtuzumab recipients had a lower incidence of BOS (22.7% versus 55.4 versus 55.9%), and its use was independently associated with lower risk of developing BOS on multivariate analysis. While both induction therapies were associated with improved survival, patients who received alemtuzumab had greater median freedom from BOS.

  18. 复合技术治疗下肢动脉硬化疗效分析%The efficacy of combined procedures for arteriosclerosis obliterations

    Institute of Scientific and Technical Information of China (English)

    吴斐; 刘俊超; 王洛波; 丁语; 李攀峰; 李阳; 王兵

    2016-01-01

    Objective To explore the treatment of multifocal lower extremity arteriosclerosis oblitera-tions. Methods From March 2014 to September 2014, combined procedures were performed on 30 lower limbs in 30 patients with multifocal lower extremity arteriosclerosis obliterations for revascularization. All the patients underwent endovascular , 20 of whom received endarterectomy , 10 received artery emboloctomy , and 8 received profundaplasty. The rates of technical success and clinical success were observed. The patients were followed up for 6-12 months to observe the total patency rate and rate of limb reservation. Results The technical success rate was 100%. The perioperative complication rate was 30% (9/30). 29 limbs gained improvement with differ-ent degree and the clinical success rate was 96.67% (29/30). The ankle-brachial index elevated 0.37 ± 0.19 on average (P < 0.001). Primary patency rate was 90% and 73% at 6 and 12 months, and 12-month limb reserva-tion rate was 97.67%. Conclusions The combined procedures for complex lower extremity arteriosclerosis oblit-erations have a higher short- to mid-term patency rate and limb reservation rate.%目地:探讨多节段下肢动脉硬化的治疗手段及临床疗效。方法:2014年3月至2014年9月,用复合技术对30例(30条患肢)多节段下肢动脉硬化患者行血运重建,30例患者均行血管腔内技术,20例行动脉内膜剥脱术,10例行动脉取栓术,8例加行股深动脉成形术。观察技术成功率,并发症发生率。随访6~12个月,观察整体通畅率和救肢率。结果:技术成功率为100%,围手术期并发症发生率为30%(9/30)。术后29例患者均有不同程度症状改善,临床成功率为96.67%,踝肱指数平均提高了0.37±0.19(P <0.05)。术后6、12个月一期通畅率分别为90%和73%,12个月救肢率为97.67%。结论:复合技术治疗多节段下肢动脉硬化具有较高的短-中期通畅率和救肢率。

  19. [The use of a synthetic vascular artificial prosthesis or arterial homograft in cases of patients with the arteriosclerosis and terminal insufficiency of kidney cured by the kidney transplantation].

    Science.gov (United States)

    Pupka, Artur; Blocher, Dariusz; Staniszewski, Tomasz; Płonek, Tomasz; Bogdan, Justyna

    2009-01-01

    Arterial transplantations were practiced in the vascular surgery since the beginning of her formation but without successes in the distant observation. Transplantation of a kidney is a routine conduct in the treatment of the decadent incapacity of a kidney. The dissertation concerns a use of arterial allografts kept using a method of a cold ischaemia in the protective liquid or synthetic vascular dacron artificial limbs or PTFE used as arterial foot-bridges at patients with the atherosclerotic obstruction aortal-pelvic, treated with the kidney transplantation. The arterial transplant is created from the aorta, arteria iliacas common and externa, femoral arteries common and superficial. A tissue material is kept using the method of the cold ischaemia and practical as the aortal foot-bridge-femoral or aortal-two-femoral at classified earlier patients being subjecteds to transfusion. The other way of a transplantation of a kidney at patients with the arteriosclerosis is the realization earlier or one-temporarily the vascular foot-bridge with use of the synthetic artificial limb. It seems that vascular artificial limbs about enlarged resistance on the contagion should be used in such a case. Sonographic examinations with duplex doppler and angiography are performed in all cases. The analysis of such cures can make a creation of the most profitable algorithm of the conduct possible in cases of patients suffering from ischaemia of lower limbs and requiring a transplantation of a kidney because of its incapacity.

  20. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    Directory of Open Access Journals (Sweden)

    JUAN I. VARGAS RT.

    2003-01-01

    Full Text Available Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP, sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativa. Se trató con prednisona con buena respuesta. Al octavo mes de tratamiento, mientras se disminuía la dosis de esteroides, comenzó con disnea y tos y aparición de nuevas opacidades pulmonares radiológicos, las que regresaron rápidamente al aumentar la dosis de esteroides. Discutimos las causas posibles de la recidiva de esta patología y su relación con la disminución de la dosis de esteroidesAlthough relapses are frequent in bronchiolitis obliterans organizing pneumonia (BOOP, there is scant information regarding the causes underlying its occurrence. We report a 63 year old woman with clinical and radiological features compatible with BOOP. No underlying cause was identified so she was thought to have cryptogenic BOOP or cryptogenic organizing pneumonia (COP. A transbronchial lung biopsy demonstrated chronic organizing pneumonia and features of proliferative bronchiolitis. She was successfully treated with prednisone. On the eighth month of steroid therapy, while tapering the dose, she begun with cough and dyspnea and developed new lung infiltrates on the chest x-ray film. The infiltrates cleared rapidly after increasing the dose of steroids. We discuss the possible causes of relapse in BOOP and its relation to steroid therapy

  1. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-γ+CD4+ regulatory T cells to control transplant arteriosclerosis.

    Science.gov (United States)

    Hsu, Wan-Tseng; Lin, Cheng-Hsin; Chiang, Bor-Luen; Jui, Hsiang-Yiang; Wu, Kenneth Kun-Yu; Lee, Chii-Ming

    2013-03-01

    Mesenchymal stem cells (MSCs) are known for their immunomodulatory functions. We previously demonstrated that bone marrow-derived MSCs effectively control transplant arteriosclerosis (TA) by enhancing IL-10(+) and IFN-γ(+) cells. The objective of this study is to elucidate the mechanism by which MSCs induce IL-10(+)IFN-γ(+)CD4(+) regulatory T type 1 (T(R)1)-like cells. In an MLR system using porcine PBMCs, MSC-induced IL-10(+)IFN-γ(+)CD4(+) cells, which confer resistance to allogeneic proliferation in an IL-10-dependent manner, resemble T(R)1-like cells. Both cyclooxygenase-derived PGE(2) and IDO help to induce T(R)1-like cells by MSCs. MSCs constitutively secrete PGE(2), which is augmented in allogeneic reactions. However, T(R)1-like cells were deficient in PGE(2) and 4-fold less potent than were MSCs in suppressing MLR. PGE(2) mimetic supplements can enhance the immunosuppressive potency of T(R)1-like cells. In a porcine model of allogeneic femoral arterial transplantation, MSC-induced T(R)1-like cells combined with PGE(2), but not either alone, significantly reduced TA at the end of 6 wk (percentage of luminal area stenosis: T(R)1-like cells + PGE(2): 11 ± 10%; PGE(2) alone: 93 ± 8.7%; T(R)1-like cells alone: 88 ± 2.4% versus untreated 94 ± 0.9%, p < 0.001). These findings indicate that PGE(2) helps MSC-induced IL-10(+)IFN-γ(+)CD4(+) T(R)1-like cells inhibit TA. PGE(2) combined with MSC-induced T(R)1-like cells represents a new approach for achieving immune tolerance.

  2. Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.

    Science.gov (United States)

    Tang, Song-tao; Su, Huan; Zhang, Qiu; Tang, Hai-qin; Wang, Chang-jiang; Zhou, Qing; Wei, Wei; Zhu, Hua-qing; Wang, Yuan

    2016-01-01

    The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin light-chain phosphorylation (p-MLC) system via the mitogen-activated protein kinase (MAPK) signaling pathway or by suppressing the myosin phosphatase-targeting subunit phosphorylation (p-MYPT)/p-MLC system in diabetes mellitus (DM). Rats were randomly divided into 4 groups, including control, high-fat diet, DM, and DM + melatonin groups. Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks. The DM significantly increased the serum fasting blood glucose and lipid levels, as well as insulin resistance and endothelial dysfunction, which were attenuated by melatonin therapy to various extents. Importantly, the aortic endothelial permeability was significantly increased in DM rats but was dramatically reversed following treatment with melatonin. Our findings further indicated that hyperglycemia and hyperlipidemia enhanced the expressions of MLCK, p-MYPT, and p-MLC, which were partly associated with decreased membrane type 1 expression, increased extracellular signal-regulated kinase (ERK) phosphorylation, and increased p38 expression. However, these changes in protein expression were also significantly reversed by melatonin. Thus, our results are the first to demonstrate that the endothelial hyperpermeability induced by DM is associated with increased expressions of MLCK, p-MYPT, and p-MLC, which can be attenuated by melatonin at least partly through the ERK/p38 signaling pathway.

  3. 血栓闭塞性脉管炎动物模型研究进展%Research Development on Animal Models of Thromboangiitis Obliterans

    Institute of Scientific and Technical Information of China (English)

    王懿; 孙蓉

    2012-01-01

    目的 对血栓闭塞性脉管炎(thromboangiitis obliterans TAO)动物模型制备方法进行综述,以寻找更加适合临床实际的造模方法.方法 对近20年国内外TAO造模方法相关文献进行整理、分析、归纳.结果 在已有TAO造模方法中,大鼠是首选造模动物,烟草致敏、寒冻、注射TAO免疫复合物等造摸方法虽然成模率都较好,也各有优缺点;以股动脉注射月桂酸改进模型与临床病理变化更相吻合,也被广泛应用于药理学活性发现和药效评价中.结论 针对TAO发病机制的造模方法目前鲜有报道.因此,在深入探讨TAO发病机制基础上的造模方法学研究与模型制备,是创新药物发现与新药药效评价的前提.%Objective To summarize preparation methods of TAO in animals, and find a more suitable method of making model in clinical research. Methods The related references in recent 20 years both at home and abroad about model making methods of TAO were analyzed, collated and summarized. Results In all the methods, rats were the first selected animal, and the methods of tobacco sensitization, cold aspic, injecting immune complex of TAO were better for making models, but each method had its merits and demerits. Method of injecting lauric acid into atreira cruralis without ZT viscose final encapsulation was most related to the clinical pathological changes, and was widely used in the research on pharmacology activity and efficacy evaluation. Conclusion The research on model making methods related with pathogenesis of TAO was rarely reported. So the research on methodology of model making related with the pathogenesis of TAO should be explored deeply, and that was the premise in discovery of innovation drug and evaluation of new drug efficacy.

  4. Study of Pathogenesis and Psychological Factors of Heart Disease of Coro nary Arteriosclerosis%冠状动脉硬化性心脏病的发病机理与心理因素的探讨

    Institute of Scientific and Technical Information of China (English)

    卜力

    2001-01-01

    Coronary arteriosclerosis is the most common cause of de ath.The author reviewed many articles concerning the etiological risk factorts of this disease ,and based on the author's own experiences and view points,and then summarized t he pathogenesis and etiological risk factors of the diseases as follows:①life e vents;②charactors of personality-type A of behaviour;③negative mood;④Diet;⑤B ad addictions.Well treatment of these factors is effective orientations and meth ods for prevention of coronary arteriosclerosis.%冠心病为死亡原因最高的疾病,探究其发病机理为预防此病的要旨。 作者复习了有关 此病的文献,加上作者自己对它的经验体会,加以阐述。其发病机理与危险因素有下列诸点 :①生活事件;②A型行为类型;③负性情绪;④饮食因素;⑤不良嗜好。根据这些因素采 取积极措施,为预防此病的主要方向。

  5. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans.

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting 2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. RESUMO A bronquiolite obliterante pós-infecciosa (BOPI) é uma doença das pequenas vias aéreas caracterizada por limitação fixa do fluxo aéreo. Portanto, os broncodilatadores e os corticosteroides inalatórios não são recomendados como opções de terapia de manutenção. Atualmente, o manejo da BOPI consiste apenas de um acompanhamento rigoroso dos pacientes afetados, visando à prevenção e ao tratamento precoce de infecções pulmonares. A incidência de BOPI tem aumentado na população pediátrica nos últimos anos. Os pacientes com BOPI caracterizam-se por um declínio progressivo da função pulmonar, associado a uma diminuição da capacidade funcional global. Relatamos aqui o caso de um homem relativamente jovem diagnosticado com BOPI, acompanhado por três anos. Ap

  6. 儿童闭塞性细支气管炎26例临床研究%Clinical characteristics of bronchiolitis obliterans in pediatric patients

    Institute of Scientific and Technical Information of China (English)

    陈德晖; 徐佳兴; 龚小燕; 钟南山; 林育能; 蓝淑玲; 潘小安; 曾庆思; 何振涛; 梁铭; 张碧云; 吴上志

    2012-01-01

    目的 分析儿童闭塞性细支气管炎(bronchiolitis obliterans,BO)的临床特点、影像学特点、实验室检查、治疗方法与临床转归.方法 2009年6月-2011年4月期间广州医学院第一附属医院儿科病房诊断为BO的住院患儿26例.分析BO患儿病原学及临床特点、危险因素、影像学特点、实验室检查、治疗方法及治疗反应.结果 26例中男18例,女8例,发病年龄4.5个月~8岁;病程(6.2±3.5)个月,随诊时间在2个月~2年.临床表现为不同程度的持续喘息(26例,100%),反复咳嗽(24例,92%)、运动不耐受(22例,85%)、气促(21例,81%)、三凹征(20例,77%)、痰鸣(16例,62%)、肺部反复湿哕音(10例,38%)、唇周紫绀(3例,12%).未见杵状指(趾).18例(69%)病原学检测阳性,支原体11例(42%),呼吸道合胞病毒4例(15%),副流感病毒、流感病毒甲型、乙型各2例(8%),博卡病毒1例(4%),其中混合感染阳性者占8例(31%).胸部X线平片检查未见异常者16例(62%),肺炎样改变10例(38%),其中仅1例疑似肺间质改变.所有病例的胸部高分辨CT(HRCT)均有肺部空气潴留、肺灌注不良的马赛克征.19例患儿检测了抗中性粒细胞胞浆抗体(ANCA),其中PANCA阳性10例(53%),CANCA阳性8例(42%).所有患儿均使用口服、全身激素与低剂量阿奇霉素治疗,其中13例(50%)治疗后咳嗽、喘息的严重程度及发作频率有明显改善,喘息、三凹征改善的天数为(7.1±4.8)d;13例(50%)激素效果不理想,或HRCT无改变者加用甲氨蝶呤后喘息、三凹征改善,时间为(16.4±11.0)d.HRCT下病灶修复时间滞后于症状改善时间,HRCT最长随访时间是1.5年,大部分病例肺部病灶仅部分吸收好转,尚无一例病灶完全吸收.结论 呼吸道感染是儿童BO发生的重要病因,临床以长期持续的喘息、咳嗽、活动不耐受、气促、三凹征为主要表现,但缺乏特异性,胸部X线平片不能提供

  7. Clinical research of artery detector combined with aggregative indicator for arteriosclerosis%应用动脉检测仪联合综合指标对动脉硬化的临床研究

    Institute of Scientific and Technical Information of China (English)

    陶伟华

    2015-01-01

    目的:通过使用动脉硬化检测仪这一无创方法了解血管疾病,及早干预并治疗,可降低心脑血管疾病的突发事件几率。方法通过对40岁以上高危人群以体检筛查的方式,应用联合检测指标共同分析、诊断血管疾病。从而有针对性的起到早期干预、早期治疗的目的。结果动脉硬化在40岁以上人群中发病率较高,超过50%的人均有不同程度周围血管硬化。引起动脉硬化的病因中高危因素依次是高血压、高脂血症、抽烟。结论这种检测方法简便、快捷、针对性强,可提高人民群众生活质量,对心脑血管疾病起到防患于未然的作用,对临床意义大重大。%Objective To understand vascular disease by using arteriosclerosis detector, and to provide early intervention treatment in order to reduce incidence of emergency in cardiovascular and cerebrovascular diseases.Methods Physical screening method was applied for high-risk group older than 40-year-old, and aggregative indicator was used for combined analysis and diagnosis of vascular disease, so as to achieve the aim of early prevention and treatment.Results Incidence of arteriosclerosis was high in people over 40-year-old, and more than 50% of those had various degree of peripheral vascular sclerosis. High-risk factors in causing arteriosclerosis were successively hypertension, hyperlipidaemia, and smoking.Conclusion This detection method is easy, quick and position-relevant, and it can improve people’s life quality, and provide protective effect for cardiovascular and cerebrovascular diseases. It has important clinical value.

  8. Nasal tolerance with collagen v protein reverts bronchovascular axis remodeling in experimental bronchiolitis obliterans Tolerância nasal com a proteína colágeno V reverte o remodelamento no eixo broncovascular na bronquiolite obliterante experimental

    Directory of Open Access Journals (Sweden)

    Ana Garippo

    2007-01-01

    Full Text Available INTRODUCTION: The precise role of the remodeling process and possible therapies for bronchiolitis obliterans remain to be established. OBJETIVE: In the present study, we sought to validate the importance of nasal collagen V tolerance to verify whether bronchovascular axis remodeling could be reverted by this therapeutic approach when compared to steroid treatment. METHODS: Mice were randomly divided into 4 groups: control, bronchiolitis obliterans, collagen V tolerance, and prednisone groups. Morphometry was employed to evaluate bronchovascular axis dimensions, collagen density, and immune cell response. Collagen V nasal tolerance and steroid-treated mice showed significantly lower values of terminal bronchiole wall thickness and reduction in peribronchovascular cells; bronchioalveolar lymphoid tissue; and CD3+, CD4+, CD8+, and CD20+ lymphocytes. A significant decrease in CD68+ macrophage density was found in prednisone-treated mice. In addition, a strong quantitative relationship was found between collagen V tolerance, and reduction in density of immune cells and collagen. RESULTS: Our results indicate that bronchovascular axis remodeling in bronchiolitis obliterans can be reverted by collagen V nasal tolerance, possibly as the result of T-cell suppression. CONCLUSION: We concluded that the tolerance effects in this model were strongly related to the improvement in bronchovascular remodeling, and these may be an appropriate targets for further prospective studies on nasal collagen V tolerance.INTRODUÇÃO: A participação precisa do processo de remodelamento e possíveis implicações no tratamento da bronquiolite obliterante ainda não está estabelecida. OBJETIVOS: Estabelecer a importância da tolerância nasal induzida pelo colágeno do tipo V e verificar se o processo de remodelamento do eixo broncovascular pode ser revertido com esta estratégia terapêutica comparada ao efeito do tratamento com esteróides. MATERIAL E M

  9. 膝以下动脉硬化闭塞症的介入治疗%Treatment and Research of Arteriosclerosis Obliterians for Infrapopliteal Arteries

    Institute of Scientific and Technical Information of China (English)

    张宇; 张志伟; 吴继东; 刘宏; 赵京; 李新宇

    2013-01-01

    Objective:To investigate the approaches , nodi, therapies of complications and prognosis of endovascular treatment for patients with infrapopliteal arteries arteriosclerosis obliterians ( ASO) .Methods:We conducted endovascular treatment for 72 patients ( 84 limbs ) between January 2008 and December 2012 and punctured femoral artery antegrade or retrograde , made lower extremity artery angiography , then used guide wire and catheter getting through the artery stenosis or occlusion .If failed, subintimal angioplasty was tried .Balloon was introduced with guiding wire to dilatating the vascular .After expansion , artery angiography was made to e-valuate if there existed residual stenosis , when residual stenosis was greater than 30%, tried again .If arterial dissection occurred , drug-coated stent was implanted .Results:84 limbs underwent endovascular treatment and 82 achieved angiographic success with 97.6%clinical success rate .16 cases with intermittent claudication in-creased claudicating distance of 500 m (50-2 500 m), resting pain of 43 cases lightened or disappeared , toe ulcer of 8 cases healed with dressing change after 3 months, 1 toe ulcer case autologous saphenous vein bypass because of in-stent thrombosis.3 cases with toe gangrene took operations and the wound healed in 3 months.1 case with anterior half foot gangrene took below -knee amputation .Conclusions:Endovascular treatment is a safe and effective method for infrapopliteal arteries ASO , and which can be repeated , achieve a high clinical success rate with a low complication rate and a high limb salvage rate .%目的:探讨膝以下动脉硬化闭塞症腔内治疗的方法、难点、并发症处理以及预后。方法:2008年1月至2011年12月,采用介入方法治疗膝以下动脉硬化闭塞症72例(84条肢体)。采取股总动脉顺行或逆行穿刺,下肢动脉造影,以导丝配合导管通过动脉狭窄段,或开通动脉闭塞段;开通失败者,尝试内膜下

  10. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM"O"P)

    Science.gov (United States)

    Crestani, B; Valeyre, D; Roden, S; Wallaert, B; Dalphin, J C; Cordier, J F

    1998-12-01

    Reports of bronchiolitis obliterans organizing pneumonia (BOOP) occurring in women after radiation therapy for breast cancer have suggested that radiation to the lung could participate in the development of BOOP. We now describe the clinical, radiographic, functional, and bronchoalveolar lavage characteristics of this syndrome in a series of 15 patients reported to the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P) in France. All 15 women (60 +/- 6 yr of age) fulfilled the following inclusion criteria: (1) radiation therapy to the breast within 12 mo, (2) general and/or respiratory symptoms lasting for at least 2 wk, (3) lung infiltrates outside the radiation port, and (4) no specific cause. The patients presented with fever, nonproductive cough, mild dyspnea, and peripheral alveolar opacities on chest radiograph with a characteristic migratory pattern. In five patients, BOOP was found at lung pathologic analysis. In all the patients dramatic improvement was obtained with corticosteroids, but relapses occurred in 12 patients while tapering or after stopping corticosteroids. This report demonstrates that a characteristic BOOP syndrome may occur after radiation therapy to the breast, including tangential radiation to the lung, thus suggesting that radiation therapy may prime the development of BOOP.

  11. 股腘动脉TASCⅡ C、D型病变的旁路转流与腔内治疗%Interventional therapy vs arterial bypass surgery for TASC Ⅱ C and D lesions of femoropopliteal arteriosclerosis obliterance

    Institute of Scientific and Technical Information of China (English)

    王帅; 孙思翘; 程志华; 孙喜伟; 王中英; 张阳; 赵文光; 王琦

    2016-01-01

    目的 总结泛大西洋协作组织(TransAtlantic InterSociety Consensus,TASC Ⅱ)C、D型股腘动脉闭塞性病变腔内介入治疗及旁路转流手术的治疗经验.方法 回顾性分析2009年1月至2013年12月经腔内介入治疗或旁路转流手术的TASCⅡ C、D型股腘动脉闭塞性病变患者的临床资料,随访146例(167条肢体),腔内介入治疗68例(73条),旁路转流手术78例(94条),分析2组患者一般资料、围手术期情况及远期通畅率、保肢率等.结果 2组保肢率(97.3%和97.9%)差异无统计学意义(x2=0.066,P>0.05);转流组术后36个月一期通畅率(71.7%)优于腔内组(42.1%)(x2=5.070,P<0.05);转流组12、24、36个月二期通畅率为94.2%、89.6%、85.1%,优于腔内组的83.1%、72.2%、57.9%,差异有统计学意义(x2值分别为4.823、5.103、5.476,P值均<0.05).转流组再狭窄、闭塞以吻合口内膜增生为主,腔内组以支架内内膜增生居多(x2=10.041,P<0.05).结论 对于TASC ⅡC、D型病变,旁路转流手术仍是首选.%Objective To summarize the treatment experience of interventional therapy in comparison with arterial bypass surgery for TASC Ⅱ C and D lesions of femoropopliteal arteriosclerosis obliterance.Methods This is a retrospective study on 146 cases (167 limbs) receiving interventional therapy or arterial bypass surgery for TASC Ⅱ C and D lesions of femoropopliteal arteriosclerosis obliterance from January 2009 to December 2013.Results The limb salvage rates of the two groups were 97.3% and 97.9%,respectively (x2 =0.066,P >0.05).For bypass surgery group,the primary patency rate of 36-month post-operation was 71.7% which was higher than the rate of interventional therapy group (x2 =5.070,P < 0.05);the secondary patency rates of 12-,24-,36-month post-operation were 94.2%,89.6%,85.1%,which were higher than the rates of interventional therapy group (x2 =4.823,5.103 and 5.476,P < 0.05).The main reasons for

  12. Applications of TCD assay in detection on cerebral arteriosclerosis of hypertensive patients%经颅多普勒超声在高血压患者脑动脉硬化检测中的应用

    Institute of Scientific and Technical Information of China (English)

    韩莉莉

    2012-01-01

    目的 研究健康体检中高血压患者脑动脉硬化经颅多普勒(TCD)检测的应用.方法 回顾性分析2010年7月~2011年7月在开封市第一人民医院体检科进行健康体检中高血压患者1 055例TCD检测结果及相关临床资料(年龄、性别、临床诊断、遗传病史等),研究TCD改变与临床的关系,为血压增高者的脑血管功能学评价提供客观血流动力学资料.结果 进行TCD检查的1 055例被检者中,脑动脉硬化频谱改变518例;颈内动脉系统单支或多支血管收缩期血流速度增高703例,其中,涡流及湍流54例;收缩期血流速度减低16例;椎基底动脉系统收缩期血流速度增高599例、减低8例.由统计学分析可知,除在男70~90岁组、女60~组外,余病例组动脉硬化检出率均高于对照组,差异具有统计学意义.在去除年龄因素的作用后,可认为男、女高血压患病均与动脉硬化有关(CMH x 男2=52.384,x 女2=13.747,均P<0.001);另ORMH 男=2.861,ORMH 女=1.718,说明男性高血压患者发生脑动脉硬化的优势比为2.861、女性高血压患者发生脑动脉硬化的优势比为1.718.TCD检测异常率高于被检者对相关疾病的知晓率.结论 TCD检测可较灵敏地反映高血压时脑血管的血流动力学改变,在高血压患者脑动脉硬化的血管功能学评价及指导临床治疗中具有重要意义.%OBJECTIVE To investigate the applications of TCD detection in physical examination of cerebral arteriosclerosis of hypertensive patients. METHODS We reviewed and analyzed the 1 055 samples of hypertension patients in Health Examination Department of Kaifeng First People's Hospital with their TCD inspected results and clinical data including of age, gender, clinical diagnosis and genetic disease from July 2010 to July 2011. Then we investigated the relationship between changes of TCD and clinical phenomenons to provide objective hemodynamic data of cerebral vascular functional

  13. Arterialização do arco venoso do pé para tratamento da tromboangeíte obliterante Arterialization of the venous arch of the foot for the treatment of thromboangiitis obliterans

    Directory of Open Access Journals (Sweden)

    Cesar Roberto Busato

    2008-09-01

    Full Text Available Em isquemia crítica sem leito arterial distal, um dos modos de irrigar o membro isquêmico é derivar o fluxo de maneira retrógrada através do sistema venoso. As primeiras tentativas de fístulas arteriovenosas terapêuticas datam do início do século passado. Realizadas na parte proximal dos membros inferiores, não obtiveram resultados favoráveis. A partir da década de 70, com os trabalhos pioneiros de Lengua, as fístulas passaram a ser estendidas até o pé, e os bons resultados apareceram em várias publicações. Os autores relatam a evolução de um caso de tromboangeíte obliterante submetida ao procedimento. Essa é uma cirurgia de indicação precisa, que requer estudo pré-operatório arterial e venoso e observância a detalhes de técnica operatória.In critical ischemia without arterial run-off, it is possible to irrigate the ischemic limb by turning the course of the flow reversely through the venous system. The first experiments with therapeutic arteriovenous fistulas date from the beginning of the last century. They were performed in the proximal area of the lower limbs, but showed unfavorable results. Since the 1970's, with the pioneer studies of Lengua, fistulas started being extended to the foot and several publications have reported good outcomes. The authors report the evolution of a case of thromboangiitis obliterans which was submitted to the procedure. This is an accurate surgical procedure which requires arterial and venous preoperative study and the observance of technical operative details.

  14. 彩色多普勒超声诊断急性脑梗死患者颈动脉硬化病变价值的探讨%Color Doppler ultrasound of carotid arteriosclerosis with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    王小燕; 蓝春勇; 钟维章; 张步林

    2009-01-01

    Objective To evaluate the application of color Doppler ultrasound (CDU) on the carotid arteriosclerosis with acute cerebral infarction. Methods Thirty cases of carotid arteriosclerosis with acute cerebral infarction were investigated using CDU,and the ultrasound findings were compared with those of digital subtraction arteriography (DSA) which served as the diagnosis gold standard method. Kappa test was performed between the results of CDU and DSA. Results The sensitivity,specificity and accuracy of B-mode and color image in the diagnosis of above the moderate degree carotid artery stenosis and occlusion were 95.5 %, 94.7 % and 95.0 %, respectively. And CDU for above the moderate degree of stenosis, the sensitivity, specificity and accuracy were 77.3%, 97.4% and 90.0%,respectively. Kappa test showed the agreement between CDU and DSA for the diagnosis of carotid artery stenosis was good, CDU morphologic mensurate Kappa = 0. 787, CDU hemodynamics mensurate Kappa = 0.669. Conclusion The agreement between CDU and DSA in the evalution of carotid artery stenosis is good. For the most of moderate and serious degrees of stenosis,CDU is a substitution for DSA. Additionally, the therapeutic regimen could be decided on the basis of the findings of CDU for 70%-99% degree of stenosis.%目的 评价彩色多普勒超声(colorDoppler ultrasound,CDU)在诊断急性脑梗死患者颈动脉硬化病变的价值.方法 应用CDu对30倒急性脑梗死患者颅外段颈动脉血管检测.每例患者均同时行数字减影血管造影(DSA)检查,并将2种检查方法的结果进行一致性检验(Kappa检验).结果 以DSA检查结果为金标准,得出了二维彩色超声诊断颈动脉中重度以上狭窄及闭塞的敏感度、特异度及准确度分别为95.5%、94.7%、95.0%,CDU频谱诊断中重度以上狭窄及闭塞的敏感度、特异度及准确度分别为77.3%、97.4%、90.0%.一致性检验(Kappa检验)结果表明CDU和DSA2种方法的检查结果的一致性良

  15. Fundus Camera in the Application of the High Blood Pressure and Arteriosclerosis Sex Retinopathy%眼底照相在高血压及动脉硬化性视网膜病变中的应用

    Institute of Scientific and Technical Information of China (English)

    欧春蓓

    2014-01-01

    目的:通过眼底血管的检查,探讨高血压病所导致高血压性视网膜病变的各种原因。方法全部患者均系统进行眼部检查,对有高血压动脉硬化性视网膜病变的患者,在全身情况允许下进行荧光眼底血管造影检查。结果106例212只患眼中高血压患者都有不同程度的眼底视网膜病变。结论通过对高血压患者眼底检查,可为高血压患者留下非常直观的资料,对高血压病的诊断治疗及预后提供重要的临床参考价值。%Objective: through checking the retinal blood vessels and explore the hypertension caused by various reasons for the hypertensive retinopathy. Methods: al patients carries on the eye test system, for patients with high blood pressure, arteriosclerosis sex retinopathy, under general situation al ows for fluorescence fundus angiography. Results:106 cases with 106 eyes hypertension patients have dif erent degree of fundus retinopathy. Conclusion:through to hypertension patients with fundus examination, can leave very intuitive information for patients with high blood pressure, for the diagnosis and treatment and prognosis of hypertension provide important clinical reference value.

  16. 308例老年高血压病患者动脉硬化检测结果分析%Analysis of Examination Results of Arteriosclerosis of 308 High Blood-pressure Senior Patients

    Institute of Scientific and Technical Information of China (English)

    黄雯; 曾小茹; 莫发敏

    2013-01-01

    目的:了解老年高血压病患者动脉硬化情况。方法:随机抽取到本院门诊就诊或住院的老年高血压病患者308例进行动脉硬化检测,测定其肱踝脉搏波传导速度(baPWV)及踝臂指数(ABI),将检测结果与同期到本院进行健康体检的100例老年健康人群进行比较分析。结果:(1)老年高血压病患者的baPWV显著高于健康对照组,ABI明显低于健康对照组。(2)高血压病患者随着血压分级的升高, baPWV依序升高,ABI依序降低。(3)并发冠心病或脑卒中的高血压病患者,baPWV显著高于无并发症者,ABI明显低于无并发症者。(4) baPWV重度异常组,同型半胱胺酸、高脂血症、并发冠心病或脑卒中、糖尿病、吸烟等危险因素明显高于baPWV轻度或中度异常组。结论:高血压是引起动脉硬化及动脉粥样硬化的独立危险因素;高血压病患者随着血压分级升高,动脉硬化程度加重;baPWV和ABI是冠心病或脑卒中的独立预测因子;高血压病患者危险因子越多,动脉硬化程度越重。%Objective:To understand the detail situation of arteriosclerosis with senior high blood-pressure patients.Method:308 cases of senior high blood-pressure patients were randomly selected from outpatients or hospitalized patients. Brachial ankle pulse wave velocity(baPWV)and anklearm index(ABI)were performed in all patients. The baPWV and ABI differences were compared between senior high blood-pressure patients and elderly healthy person,which were randomly selected from the physical examination branch physical exam in the same time.Result:(1)The baPWV values of senior high blood-pressure patients were significantly higher than that of the healthy group,while the ABI values of seniorhigh blood-pressure patients were obviously lower.(2)With the grade of blood pressure moving higher,The baPWV value of high blood-pressure patients went higher,while the ABI value

  17. [Haemodynamic role of blood-plasma circulating cell-free DNA and contained therein high-molecular-weight CpG-rich fraction in pathogenesis of arterial hypertension and atherosclerosis obliterans of carotid arteries].

    Science.gov (United States)

    Konorova, I L; Veĭko, N N; Ershova, E S; Antelava, A L; Chechetkin, A O

    2009-01-01

    blood plasma. A higher level thereof leads to a rise in the HR and to the appearance of neurological symptomatology. Hence, CpG-DNA circulating in the composition of pDNA is a constantly acting endogenous blood factor decreasing the HR (the Toms's effect) and normalizing AP under physiological conditions, being however a cause of their increase and impairment of blood circulation in the pathogenesis of AH and atherosclerosis obliterans of the CAs.

  18. 人股动脉粥样硬化相关蛋白的鉴定及其生物学作用%Proteomics analysis on pathogenesis of human atherosclerosis obliterans in human femoral artery

    Institute of Scientific and Technical Information of China (English)

    赵振; 赵海光; 蒋米尔

    2011-01-01

    Objective We used proteomic profiling in an attempt to differentiate and identify histological proteins that were associated with atherosclerosis obliterans (ASO) of human femoral artery.Methods We comparatively analyzed the proteome of 8 atherosclerotic and 5 normal femoral arteries. The differentially expressed proteins were visualized by two dimensional electrophoresis (2-DE) and sequenced by matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS). The protein identification program was used to search the National Center for Biotechnology Information (NCBI) database and International Protein Index (IPI). Results A total of 53 distinct spots corresponding to 13 different proteins were identified by MALDI-TOF-MS using the NCBI and IPI databases. The function information of these 13 proteins mainly involved the pathogenetic mechanisms such as inflammation, innate immunity, oxidative stress, lipid metabolism, amyloid degeneration and so on. Conclusion ASO is associated with distinct patterns of protein expression in the femoral arteries, and differentially expressed 13 proteins may contribute to the pathogenesis. These findings might provide needed biomarkers for ASO and new insight into its pathophysiology.%目的 应用比较蛋白质组学方法探讨人动脉粥样硬化闭塞症(ASO)差异蛋白质的表达及其在ASO发病机制中的作用.方法 选取ASO股动脉8例及正常股动脉5例,提取组织蛋白质,行双向凝胶电泳分离、质谱分析及数据库查询,获得差异蛋白信息.结果 成功建立ASO和正常股动脉双向电泳图谱,含量相差大于2倍以上的蛋白质53个,27个上调,26个下调,质谱鉴定出13种蛋白质,主要与炎症、免疫、氧化应激、脂质代谢等相关.结论 ASO与正常股动脉蛋白质组明显差异,差异蛋白质可能在ASO中起重要作用.

  19. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo; Yang, Dong Hyun; Seo, Joon Beom; Chae, Eun Jin; Lee, Jeongjin [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Songpa-gu, Seoul (Korea); Hong, Soo-Jong; Yu, Jinho; Kim, Byoung-Ju [University of Ulsan College of Medicine, Department of Pediatrics, Asan Medical Center, Seoul (Korea); Krauss, Bernhard [Siemens Medical Solutions AG-Computed Tomography, Forchheim (Germany)

    2010-09-15

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 {+-} 6.4 HU vs 26.1 {+-} 6.5 HU; P < 0.001) and CT density (-892.8 {+-} 25.4 HU vs -812.3 {+-} 38.7 HU; P < 0.001) values were significantly lower in hyperlucent regions than in normal lung regions. Xenon and CT density values showed significant positive correlation for the entire lung in 16 children ({gamma} = 0.55 {+-} 0.17, P < 0.001 or =0.017) and for hyperlucent regions in 13 children ({gamma} = 0.44 {+-} 0.16, P < 0.001 or =0.001-0.019). Indexed volumes and volume percentages of hyperlucent lung regions and ventilation defects showed strong negative correlations with forced expiratory volume [FEV1, ({gamma} = -0.64-0.85, P {<=} 0.006)], FEV1/forced vital capacity [FVC, ({gamma} = -0.63-0.84, P {<=} 0.008)], and forced midexpiratory flow rate [FEF{sub 25-75}, ({gamma} = -0.68-0.88, P {<=} 0.002). Volume percentages of xenon ventilation defects (35.0 {+-} 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 {+-} 18.6%). However, mismatches between the

  20. Clinical Observation on Aerosol Inhalation Combined with Oral Corti Cos-teroids in Treatment of Bronchiolitis Obliterans in Children%雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床分析

    Institute of Scientific and Technical Information of China (English)

    薛斌

    2016-01-01

    Objective To discuss and observe the clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children. Methods 116 cases of children with bronchiolitis obliterans diagnosed from December 2010 to June 2015 were collected and randomly divided into two groups with 58 cases in each, the observation group were treated with budesonide inhalation aerosol and oral corti costeroids, the control group were also treated budes-onide inhalation aerosol and oral corti costeroids, but the dose was different, and the treatment effects and asthma control situations were compared. Results The effective rate and asthma control scale were respectively 93.1%and (23.4±1.2) marks in the observation group, which were obviously better than those in the control group, P<0.05. Conclusion The clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children is satisfactory.%目的:探讨雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床疗效。方法方便选取2010年12月—2015年6月确诊的116例闭塞性细支气管炎患儿,随机分为观察组(布地奈德雾化吸入和口服泼尼松)和对照组(同观察组,但剂量不同)各58例,比较治疗效果和哮喘控制情况。结果观察组有效率为93.1%,哮喘控制得分为(23.4±1.2)分,均明显优于对照组(P<0.05)。结论雾化吸入与口服糖皮质激素协同治疗儿童闭塞性细支气管炎临床效果满意。

  1. Bronquiolite obliterante pós-infecciosa: aspectos clínicos e exames complementares de 48 crianças Post-infectious bronchiolitis obliterans: clinical aspects and complementary testing of 48 children

    Directory of Open Access Journals (Sweden)

    Rosaly Vieira dos Santos

    2004-02-01

    obliterans (BO is variable. OBJECTIVE: Substantiate the clinical characteristics, the evolution and the complementary tests of 48 patients with post infectious bronchiolitis obliterans (BO. METHOD: Observational and retrospective study. Diagnosis of BO was based upon clinical criteria, CT scan findings and exclusion of other diseases. History prior to diagnosis and complementary tests were evaluated as well as initial and final values of oxygen saturation. RESULTS: Mean age of patients at the acute stage of the infectious disease was of 9.6 Thirty two of the patients were male. All were hospitalized during the acute stage, 14 of them (29% in the ICU. Four patients died two years after onset of acute bronchiolitis. During evolution all required emergency care due to exacerbation of the pulmonary condition and 24 (50% were hospitalized, 2 of them in the ICU. The majority continued presenting cough, wheezing, crackles and hyperinflation, however to a lesser degree. Mean of initial arterial saturation was of 89% and final of 92%. The most common infectious agents in the sputum samples were H. influenzae, S. pneumoniae and M. caterrhalis. Increased serum IgM and IgG were found in 9 and 7 patients respectively. The most frequent findings at thorax CT scan were mosaic perfusion, bronchioectasis, atelectasis and bronchial wall thickening. CONCLUSION: Post infectious BO is a chronic and severe disease with persistent symptoms that in general affect infants. Positive serum cultures and increased serum immunoglobulins are suggestive of a chronic infectious inflammatory condition.

  2. Adenovirus-mediated heme oxygenase -1 gene therapy ameliorates transplant arteriosclerosis and the underlying mechanisms%血红素氧合酶-1基因治疗减缓移植物血管病及机制

    Institute of Scientific and Technical Information of China (English)

    赵波; 宫念樵

    2012-01-01

    目的 观察血红素氧合酶-1(HO-1)基因治疗减缓同种移植物血管病的效果,探讨其机制.方法 以BN-Lewis大鼠血管移植为对象,依据基因治疗方案分为4组:同系对照组、空白对照组、载体对照组、腺病毒介导的HO-1( AdHO-1)组.移植后2个月,观察各组移植物纤维化和内膜增生,检测T细胞(CD3+)、B细胞(CD45RA)和巨噬细胞(CD68+)浸润数量,逆转录-聚合酶链反应(RT-PCR)和Western blot检测移植物HO-1基因和蛋白的表达,酶联免疫吸附试验(ELISA)法检测受体血清白细胞介素(IL)-10的浓度.结果 同系对照组无移植物血管病表现,空白对照组和载体对照组大量纤维沉积,AdHO-1组纤维沉积轻微.血管内膜/(内膜+中膜)百分比4组分别为7.6%、81.4%、85.9%、15.9%.每400倍视野浸润细胞数4组分别为T细胞(9.2±1.6、92.3±11.6、89.6±17.8、39.3±10.1)、B细胞(3.6±1.1、72.6±11.8、66.6±10.9、30.6±9.9)、巨噬细胞(7.5±1.2、78.5 ±21.7、72.5 ±19.8、34.5±18.7).血清IL-10浓度4组分别为(50.2±20.1)、(40.2±11.1)、(38.6±19.3)、(481.2 ±69.1)ng/L.AdHO-1组与空白对照组和载体对照组间差异有统计学意义(P<0.05).AdHO-1基因治疗增高了移植血管HO-1基因和蛋白的表达.结论 AdHO-1基因治疗减缓同种移植物血管病,移植物纤维化和内膜增生明显减轻.AdHO-1基因治疗下调了T细胞、B细胞和巨噬细胞在移植物中的浸润,增加了HO-1和IL-10的表达,IL-10-HO-1通路的活化可能是移植血管得到保护的重要原因.%Objective To observe the effect of adenovirus-mediated heme oxygenase-1 (AdHO-1) gene therapy on allograft transplant arteriosclerosis and to elucidate the underlying mechanisms.Methods Aorta transplants in BN-Lewis rats were used and divided into four groups:isograft group,control group,vector control group,and AdHO-1 group.The allograft fibrosis and neointimal proliferation were observed two months post transplant

  3. Changes of arteriosclerosis index level in women with pregnancy induced hypertension%妊娠期高血压疾病患者动脉硬化指数水平变化

    Institute of Scientific and Technical Information of China (English)

    周丽琴

    2011-01-01

    Objective To examine serum total cholesterol (TC ) and high density lipoprotein cholesterol ( HDL - C ) level in woman with Pregnancy induced hypertension ( PIH ) , arteriosclerosis index (AI) = (TC - HDL - C)/HDL - C,and elucidate the effect of it on the development of the disease. Methods Serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL - C) level were measured in 50 normal pregnant women (control group) ,50 pregnant women with gestational hypertension ( GH group) and 30 pregnant woman with Pre - Eclampsia( Pre - Eclampsia group). The Pre - Eclampsia group was further divided into the following subgroup: mild, and severe Pre - Eclampsia group. We used indirect - precipitation and enzymic method to measure serum total cholesterol ( TC) and high density lipoprotein cholesterol ( HDL - C ) level. Results The AI levels were found significant higher in gestational Hypertension group than that in control group, The AI levels were higher in all Pre - Eclampsia subgroups than that in control, and higher than gestational Hypertension group, Result is statistically significant (P < 0. 05). Conclusions This study has demonstrated that AI levels are elevated in pregnant woman with PIH and associated with severity of the disease.%目的 检测妊娠期高血压患者及子痫前期(包括轻度和重度)患者血清中胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,运用公式动脉硬化指数[AI=(TC - HDL - C)/HDL - C]以探讨妊娠期高血压疾病发病中动脉硬化指数水平变化.方法 应用酶法及间接沉淀法检测50例妊娠期高血压患者(妊高组)、30例子痫前期患者及50例正常妊娠妇女(对照组)血清中胆固醇(TC)及高密度脂蛋白胆固醇( HDL - C)水平.结果 妊高组血清中动脉硬化指数水平高于对照组,子痫前期组血清中动脉硬化指数水平明显高于妊高组及对照组,且有显著性差异(P<0.05).结论 动脉硬化指数水平与妊娠高血压疾病密切

  4. 中老年人体测量学指标与动脉硬化指标的关系%Correlation between anthropometric parameters and arteriosclerosis biomarker in the middle-aged and the elderly

    Institute of Scientific and Technical Information of China (English)

    刘严; 齐丽彤; 马为; 杨颖; 孟磊; 张宝娓; 霍勇

    2014-01-01

    目的:探讨中老年人人体测量学指标与动脉硬化指标之间的相关性。方法:选择北京市石景山区接受横断面调查的中老年居民1626人,年龄45~90岁,平均年龄(61.60±10.22)岁,分为健康组、高血压组和糖尿病组。由专人测量受试者身高、体重、腰围(waist circumference,WC)等指标,计算出腰身指数(waist to height ratio,WHtR)和体质量指数(body mass index,BMI)。采用无创检测设备分别测量反射波增强指数(augmentation index,AI)、踝脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)、踝臂指数(ankle-brachial index,ABI)、颈动脉内-中膜厚度( intercellular membrane thickness ,IMT)等动脉硬化指标,分析各项指标间的相关性。结果:中心型肥胖者(男性WC>85 cm、女性WC>80 cm或WHtR>0.5)和肥胖者(BMI>28 kg/m2)百分比在高血压组和糖尿病组之间差别不显著(P>0.05),但均显著高于健康组(P<0.01)。 BMI与中心型肥胖测量指标WC和WHtR呈中度正相关(r分别为0.710和0.716)。在健康组,人体测量学指标(WC和WHtR)与baPWV、IMT和ABI呈正相关,与AI75呈负相关;BMI与IMT呈正相关,与AI75呈负相关,与baPWV和ABI不相关。糖尿病组BMI与baPWV呈负相关;高血压组BMI与baPWV、AI75呈负相关,WC与AI75呈负相关。 baPWV与人体测量学指标的一元线性回归分析结果显示,baPWV与WHtR回归直线方程为y=0.949+1.379x(R2=0.046,P<0.001),baPWV与WC回归直线方程为y=1.133+0.006x(R2=0.027,P<0.001);baPWV与BMI不具有线性相关关系(P=0.62)。结论:WHtR和WC预测动脉硬化优于BMI,中心型肥胖的人体测量学指标可作为心血管风险的预测因子。%Objective:To investigate the correlation between anthropometric indices and arteriosclerosis detection indicators in the

  5. Test de marcha de seis minutos en niños con bronquiolitis obliterante postviral: Correlación con espirometría Six minute walk test in children with post-infectious obliterans bronchiolitis: Its relation with spirometry

    Directory of Open Access Journals (Sweden)

    DANIEL ZENTENO A

    2008-03-01

    Full Text Available la Bronquiolitis Obliterante (BO postviral produce alteraciones en la función pulmonar que pueden repercutir en la capacidad para realizar ejercicio, la cual se puede evaluar con el test de marcha de 6 minutos (TM6. Objetivo: Estudiar con esta prueba a niños con BO postviral y determinar la relación entre variables espirométricas y los resultados del TM6. Veintisiete pacientes, se estudiaron con espirometría basal y TM6. Se relacionaron variables espirométricas con resultados del TM6: distancia caminada, índice de Borg (IB, saturación de oxígeno (Sa0(2 y frecuencia cardíaca (FC, mediante Rho de Spearman utilizando SPSS 11,5. No hubo correlación entre la distancia caminada y ninguna variable espirométrica; la CVF sólo se correlacionó con Sa0(2 final (rho = 0,4; p = 0,02. El resto de las variables espirométricas se correlacionaron con IB, Sa0(2 y FC; destacando VEF1 con: IB (rho = -0,7; p Post infectious obliterans bronchiolitis (OB causes persistent pulmonary function impairment and could affect patient ability to perform exercise. Six minute-walk test (6MWT is a useful tool to study these aspects. Objective: Children with OB were evaluated with spirometry and 6MWT and the relationship between spirometrics measurements and 6MWT were determined. Twenty-seven children with OB were studied with a base line spirometry and 6MWT. Correlation between spirometry and 6MWT: covered distance, Borg index (BI, oxygen saturation (0(2S and heart rate (HR, were carried out using Rho of Spearman with SPSS 11.5. There was not relation between the covered distance and spirometrics values; only FVC correlates with final 0(2S (rho = 0.4; p = 0.02. The other spirometrics variables correlates with BI, 0(2S andHR; Interestingly FEV1correlates with: BI (rho = -0.7; p < 0.01, 0(2S (rho = 0.5; p < 0.01 and HR (rho = -0.5; p < 0.01. BI was significant related to FEV1/FVC (rho = -0.7; p < 0.01 and FEF25-75 (rho = -0.8; p < 0.01. Airflow obstruction

  6. 盐酸沙格雷酯治疗下肢动脉硬化闭塞症的疗效观察%Effect of sarpogrelate hydrochloride for patients with atherosclerotic obliterans of legs

    Institute of Scientific and Technical Information of China (English)

    任师颜; 王非; 钱松屹; 樊雪强; 刘鹏

    2012-01-01

    Objecive:To evaluate the effect of sarpogrelate hydrochloride (anplag)for patients with atherosclerotic obliterans (ASO)of legs .Methods; The patients with ASO of legs were divided into sarpogrelate hydrochloride group (n=46)and control group (n =42).The patients in sarpogrelate hydrochloride group received sarpogrelate hydrochloride(100mg,tid)and aspirin(100mg.qd).whereas the patients in control group were administered aspirin (100mg,qd)only.The average therapeutic course was 130 days.Clinical manifestation,Rutherford type and ankle brachial index (ABl)were studied.Results:In comparison with control group,the severity of pain,Rutherford type 0 and 1 were improved with statistic significance(P<0.05,P<0.01).Incidence of patients with claudi-cation decreased from 56.6% before treatment to 28.3% after treatment; claudication distance was prolonged(P< 0.01);ABI were improved(0.74±0.17vs0.86±0.18,P<0.01).Conclusion:Anplag has therapeutic effect for patients with ASO of legs.%目的:研究盐酸沙格雷酯对下肢动脉硬化闭塞症(ASO)患者的疗效.方法:ASO患者分为盐酸沙格雷酯治疗组(n=46)和对照组(n=42).治疗组口服盐酸沙格雷酯、阿司匹林,对照组仅口服阿司匹林.每例患者口服阿司匹林100mg/d,盐酸沙格雷酯100mg,3次/d,服用130d.观察患者的临床表现、Rutherford 分型、踝肱指数(ABI)和药物不良反应.结果:治疗组患者感觉疼痛改善,步行距离增加,Rutherford 分型0级和1级患者的改善具有显著性差异(P<0.05,P<0.01).治疗后间歇性跛行从56.6%降低为28.3%,跛行距离显著延长(116.3±72.3m vs 243.5±175.3m,P<0.01),ABI指数显著改善(0.74±0.17 vs 0.86±0.18,P<0.01).结论:盐酸沙格雷酯对ASO患者有明显的治疗作用.

  7. 重组人脑利钠肽对动脉硬化大鼠血管内皮功能的影响%The effects of Brain Natriuretic Peptide on the function of rats arteriosclerosis model vascular endothelial

    Institute of Scientific and Technical Information of China (English)

    周琳; 张静; 袁天阳; 李扬雪; 徐艳玲; 戴琎

    2013-01-01

    目的 探讨rhBNP对动脉粥样硬化(AS)大鼠模型血管内皮功能的影响.方法 40只健康wistar大鼠,随机分为对照组、模型组、处理组各8只.处理组分别给予硝酸酯类、阿魏酸钠、重组人脑利钠肽皮下注射.采用酶联免疫吸附(ELISA)方法测定各组大鼠处理前后血清中血栓素B2(TXB2)和6-酮前列腺素F1a(6-Keto-PGF1a)的含量,并且光镜下观察各组处理前后大鼠的主动脉内膜细胞的变化.结果 1)处理组药物治疗后,血清中TXB2均下降、6-Keto-PGF1a均升高,与治疗前比较有统计学差异(P0.05);3)光镜的观察结果提示:模型组血管管腔内有附壁斑块;平滑肌细胞排列紊乱;处理组内膜较光滑,局部有MC粘附,偶可见EC缺失,但好于模型组,各处理组之间未见明显差别.结论 rhBNP通过保护血管内皮功能具有抗动脉粥样硬化的作用.%Objective The effects of Brain Natriuretic Pcptidc on the function of rats arteriosclerosis model vascular endothelial. Methods 40 healthy wistar rats, divided into five groups at random, eight rats in contorl group, eight in model group,each of the treatment group of nitratcs(Hua rcn xin shu),Sodium Fcrulatc(Haisi) ., rhBNP (xinhuosu) model group were eight rats. Adopt enzyme-linked immunosorbent adsorption (ELISA) methods to determine each rat treatment and scrum blood TXB2 and 6-Kcto-PGFla content,and light-microscopy each rat before and after processing the aortic lining cells changes. Results a. The treatment group scrum TXB2 and 6-Kcto-PGFla levels obviously different than bcforc(P 0. 05). c. Optical microscope observations, the control group vascular lumen, no calcium sediment, big plaques can be seen. Smooth muscle cells is boom and ectoblast is conjunction tissue, arranging disorganized. The treatment group is smoother,local macrophagc adhesion,visible EC missing,but better than model group,and the treatment group showed no significant difference between. Conclusion rhBNP can not

  8. Segmented colon ischemia associated with thromboangiitis obliterans

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    Francisco de Saltes Collet e Silva

    Full Text Available A necrose isquêmica do colo associada à tromboangeite obliterante é rara e grave, com uma mortalidade elevada. A tromboangeite obliterante ocorre em pacientes jovens e as manifestações digestivas, raras nesta moléstia, ocorrem posteriormente aos acometimentos dos membros. Relata-se caso de um paciente com necrose segmentar isquêmica de colo com tromboangeite obliterante.

  9. Safety evaluation during rotational manipulation of the cervical spine in the patients with arteriosclerosis by sonography on the vertebral arteries%椎动脉超声对动脉硬化患者颈椎旋转手法治疗的安全性评价

    Institute of Scientific and Technical Information of China (English)

    滕红林; 王靖; 张纯武; 吴春雷; 朱旻宇; 赵亮; 吕超

    2011-01-01

    目的:通过对伴有动脉硬化中老年患者进行模拟旋颈状态下颈椎椎动脉超声检查,权衡手法的好处和潜在的风险,为临床医师对颈椎采取手法治疗前提供参考.方法:对208例动脉硬化患者进行彩色多普勒超声检查,观察椎动脉的狭窄程度以及血流充盈程度,血流频谱形态等.测量血流参数[收缩期峰值血流速度 (VMAX)、舒张末期流速(VMIN)、平均血流速度(VTAMX)]、反映血管舒缩和阻力状况的阻力指数(RI)、反映血管顺应性和血管弹性的搏动指数(PI).结果:超声显示在旋颈状态下VA血流变细,血管迂曲及局部受压狭窄;伴有动脉粥样硬化者,可见血管内膜粗糙,管壁增厚,回声增强,有动脉粥样硬化小斑块形成及管腔狭窄,椎骨段VA走形迂曲,VA平均内径<3 mm.在过屈位旋颈后血流减少甚至部分患者彩色血流中断而不显像.在正常仰卧位时所测得的血流参数与对照组相比差异无统计学意义,经左右旋颈45°后,检测所得两组血流动力学参数与对照组相比开始出现差异,当过屈位旋颈45°后,两组血流动力学参数呈现显著性差异.结论:彩色多谱勒超声可以观察椎动脉形态的变化并对血流进行定量测定,其检查操作便捷,敏感性高,可以作为颈椎手法前筛查潜在VA损伤的动脉硬化患者的方法之一.%Objective :To weight the pros and cons before rotatory manipulation of the cervical spine in the patients with arteriosclerosis. Methods :208 cases with arteriosclerosis underwent sonography to explore the course and stenosis of the vertebral arteries. The VMAX,VMIN, VTMAX and RI were also measured. Results: The results showed the decreased blood stream and local compression of the VA during the rotatory manipulation of the cervical spine. In cases with arteriosclerosis, coarse inner membrane, thickening of the arterial wall and increased echogenicity were found. The blood stream decreased or even

  10. Función pulmonar y calidad de vida en niños y adolescentes con bronquiolitis obliterante por adenovirus Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection

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    Stefhanie Nayar E

    2011-09-01

    Full Text Available Introducción: La infección por adenovirus es una causa importante de neumonía en niños chilenos. La bronquiolitis obliterante (BOPI es la complicación más importante. Existen pocos estudios donde evalúen la función pulmonar y la calidad de vida de los pacientes con BOPI. Objetivo: Evaluar la función pulmonar y la calidad de vida de los pacientes con BOPI y la correlación entre ambas variables. Métodos: Se incluyeron 14 niños con BOPI en elpoliclínico de la unidad de broncopulmonar de un hospital público de niños. Período de estudio: abril de 2009-abril de 2010. La función pulmonar se evaluó en una visita médica por espirometría, curva flujo / volumen y la determinación de volumen de gas intratorácico. Los índices analizados fueron los siguientes CVF, VEF1, FEV25-75, VEF1/CVF, VR,CPT, VR y VR / CPT. En la misma visita se realizó una encuesta auto-administrada de Calidad de Vida (PedsQL, versión 4.0, español de Chile para investigar la calidad de vida global, física y psi-cosocial. Se aplicó la correlación lineal de Pearson entre calidad de vida y los parámetros de función pulmonar. Se consideró estadísticamente significativo unp Introduction: Adenovirus infection is an important cause of pneumonia in Chilean children. Postinfectious Bronchiolitis Obliterans (PIBO is the most important complication. There are few studies assessing pulmonary function and quality of life in PIBO patients. Objective: The aim of this study is to assess the pulmonary function and the quality of life ofpatients with PIBO and the correlation between both variables. Methods: 14 children with PIBO in follow up at the pediatric pulmonology outpatient clinic of a public children hospital were included in this study. Study period: April 2009 - April 2010. Pulmonary function was assessed in a medical visit by spirometry, flow/volume curve and intrathoracic gas volume measurement. The following indices were analyzed FVC, FEV1, FEV25-75, FEV1/FVC

  11. Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans

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    Rita Mattiello

    2010-08-01

    Full Text Available OBJETIVO: Descrever a função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa (BOPI e avaliar potenciais fatores de risco para pior função pulmonar. MÉTODOS: A função pulmonar de 77 participantes, com idades de 8-18 anos, foi avaliada por meio de espirometria e pletismografia. Os seguintes parâmetros foram analisados: CVF, VEF1, FEF25-75%, VEF1/CVF, VR, CPT, VR/CPT, volume de gás intratorácico e specific airway resistance (sRaw, resistência específica das vias aéreas. Foi utilizada a regressão de Poisson para investigar os seguintes potenciais fatores de risco para pior função pulmonar: sexo, idade do primeiro sibilo, idade ao diagnóstico, história familiar de asma, exposição ao tabaco, tempo de hospitalização e tempo de ventilação mecânica. RESULTADOS: A idade média foi de 13,5 anos. Houve uma diminuição importante de VEF1 e FEF25-75%, assim como um aumento de VR e sRaw, característicos de doença obstrutiva das vias aéreas. Os parâmetros mais afetados e as médias percentuais dos valores previstos foram VEF1 = 45,9%; FEF25-75% = 21,5%; VR = 281,1%; VR/CPT = 236,2%; e sRaw = 665,3%. Nenhum dos potenciais fatores de risco avaliados apresentou uma associação significativa com pior função pulmonar. CONCLUSÕES: As crianças com BOPI apresentaram um padrão comum de comprometimento grave da função pulmonar, caracterizado por uma obstrução importante das vias aéreas e um expressivo aumento de VR e sRaw. A combinação de medidas espirométricas e pletismográficas pode ser mais útil na avaliação do dano funcional, assim como no acompanhamento desses pacientes. Fatores de riscos conhecidos para doenças respiratórias não parecem estar associados a pior função pulmonar em BOPI.OBJECTIVE: To describe the pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans (PIBO, as well as to evaluate potential risk factors for severe impairment of

  12. Avaliação do estado nutricional de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Assessment of nutritional status in children and adolescents with post-infectious bronchiolitis obliterans

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    Vera Lúcia Bosa

    2008-08-01

    bronchiolitis obliterans and to analyze associations with clinical and nutritional factors. METHODS: The study included 57 patients. Nutritional status was assessed using z scores for weight/age, stature/age, weight/stature in children, and stature/age and body mass index percentiles in adolescents. Body composition was assessed via tricipital skin folds, subscapular skin folds, and the sum of both plus the muscular circumference of the arm; pulmonary function was also investigated in subjects over 8 years old. RESULTS: The high percentages of malnutrition and risk for malnutrition are noteworthy: 21.7 and 17.5%, respectively. Among children, weight/age and stature/age detected higher percentages of malnutrition (21.6 and 16.2%, while weight/stature underestimated this diagnosis. Among adolescents, body mass index detected a high percentage of malnutrition (25% and of risk for malnutrition (20%. Body composition analysis detected 51% of patients with low muscle reserves, and the majority of patients had normal fat reserves. Compromised pulmonary function was associated with poor performance at exercise (r = 0.434; p = 0.024. Malnutrition and/or nutritional risk and low muscle reserves were significantly associated with the 6-minute walk test (p = 0.032; p = 0.030. There was no association between spirometry and the nutritional variables (p > 0.05. CONCLUSIONS: These results emphasize the need for nutritional intervention, and suggest that, in addition to using weight and height indices for nutritional assessment, it is necessary to combine these with an analysis of body composition, so that a larger number of patients with malnutrition and/or at an increased risk of developing malnutrition may be identified and correctly managed.

  13. Revascularization for lower limbs thromboangiitis obliterans-early and mid-term outcome report%下肢血栓闭塞性脉管炎血管重建术近中期结果

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    曾嵘; 叶炜; 李拥军; 邵江; 郑月宏; 刘昌伟

    2013-01-01

    Objectives To summarize the outcome of revascularization for lower limbs thromboangiitis obliterans (TAO) and evaluate risk factors affected outcomes.Methods Between January 2008 and December 2011,a consecutive series of 24 TAO patients with lower limb ischemia were underwent revascularization.All the patients were male.The mean age was (33 ± 6) years (24-43 years).All patients presented with history of heavy smoking.Fifteen patients (62.5%) presented with ulcer or gangrene,7 cases (29.2%) presented with rest pain,the rest 2 cases (8.3%) presented with severe intermittent claudication.Eight cases underwent bypass,including 6 autogenous vein graft,1 prosthesis graft and 1 hybrid graft; 7 cases underwent catheter-directed thrombolysis combined with angioplasty; 3 cases underwent angioplasty and stenting directly; the rest 6 cases underwent thromboectomy and/or endarterectomy.The technical success,amputation and patency of target vessel were reported.Some risk factors were evaluated by multi-factors regression analysis to identify whether influenced outcomes.Results Seventeen cases (70.8%) harvested primary technical success.Three cases (12.5%) suffered with major amputation due to failure of revascularization.Eight cases with bypass all were successful,4 cases with thrombolysis got success,2 cases with primary angioplasty and stenting got success,while the 3 cases with thromboemctomy and/or endarterectomy got success.Among the 7 failed cases,3 cases needed major amputation,2 cases underwent re-operation,and the rest 2 cases got conservation treatment.All the patients had effective followup between 1 and 40 months (mean (17 ± 11) months).No death occurred during the follow-up.Primary patency,secondary patency and limb salvage rate were 45.8% (11/24),62.5% (15/24),and 79.2% (19/24),respectively.Risk factors regression analysis showed patients with ulcer or gangrene before revascularization got significant worse outcomes (Wald = 4.018,P = 0.043).Bypass

  14. Guía clínica para el diagnóstico y cuidado de niños/adolescentes con bronquiolitis obliterante post-infecciosa, 2009 Clinical guide for diagnosis and care of children and adolescents with post-infectious bronchiolitis obliterans, 2009

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    LUIS E VEGA-BRICEÑO

    2009-01-01

    Full Text Available La bronquiolitis obliterante (BO es un síndrome clínico poco frecuente en niños, caracterizado por la obstrucción crónica al flujo de aire asociado a cambios inflamatorios y distintos grados de fibrosis en la vía aérea pequeña. Si bien existen muchas etiologías, la causa más frecuente se asocia a infecciones respiratorias virales, principalmente adenovirus. No existe un consenso para establecer su diagnóstico; sin embargo, se considera un espectro de síntomas persistentes asociados a un patrón en mosaico, bronquiectasias y atelectasias persistentes. El papel de la biopsia pulmonar ha sido cuestionado por su bajo rendimiento, invasividad y complicaciones. No existe un tratamiento específico por lo que el manejo es soporte. Probablemente la mejor estrategia constituya el empleo de antibióticos en forma agresiva, soporte kinésico y nutricional constante y una precoz rehabilitación pulmonar. Estas guías clínicas representan un esfuerzo multidisciplinario, basado en evidencias actuales para brindar herramientas prácticas para el diagnóstico y cuidado de niños y adolescentes con BO post infecciosa.Bronchiolitis obliterans in children is an infrequent clinical syndrome, characterized by chronic airflow obstruction associated to inflammatory changes and different degrees of fibrosis in the small airways. Etiologies are varied but the most frequent one is the association with viral infections, mainly adenovirus. There is no consensus regarding diagnostic criteria, but a spectrum of persistent symptoms together with a mosaic pattern, bronchiectasis and persistent atelectasis is considered useful. Pulmonary biopsy has been questioned because of its low yield, invasiveness and complications. No specific treatment is available, therefore its treatment is supportive. Probably the best strategy is the aggressive use of antibiotics, constant kinesic and nutritional support and early pulmonary rehabilitation. This clinical guide represents

  15. Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved? Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: um mistério a ser resolvido?

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    Edvaldo Luiz Ramalli Jr

    2011-09-01

    Full Text Available Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridgesDiversos estudos demonstram que as porções intramiocárdicas das artérias coronárias são poupadas da arteriosclerose, envolvendo aspectos morfológicos, embriológicos, biomecânicos e aspectos fisiopatológicos. A função endotelial é significativamente afetada no segmento de transição, tal como estimado pela resposta vasoativa para acetilcolina (Ach. Esses achados sugerem que ponte miocárdica pode fornecer proteção contra a arteriosclerose, por contrariar os efeitos negativos da disfunção endotelial. O fenômeno dessa proteção da porção intramiocárdica merece maior investigação científica em todas as frentes de pesquisa. Maiores conhecimentos sobre os aspectos morfológicos, biomecânicos e, principalmente, fisiológicos e embriológicos podem ser a chave para uma futura janela de oportunidades de terapia e prevenção da doença arterial crônica. Nessa revisão, discutem-se, também, possíveis abordagens terapêuticas para fenômenos coronarianos isquêmicos causados por pontes miocárdicas

  16. The effect observation of rosuvastatin and simvastatin on elderly patients with lower limb arteriosclerosis disease%瑞舒伐他汀与辛伐他汀抗老年人下肢动脉硬化疾病效果观察

    Institute of Scientific and Technical Information of China (English)

    刘小芳

    2015-01-01

    Objective:To observe The effect of rosuvastatin and simvastatin on elderly patients with lower limb arteriosclerosis disease.Methods:65 cases of elderly patients with lower extremity arterial disease were divided into two groups.The experimental group selected rosuvastatin treatment,and the control group selected simvastatin treatment.Results:After treatment,the experimental group of TC,TG,HDL-C,LDL-C,hs-CRP were significant improved;after treatment,the lower extremity arterial intima-media thickness,arterial stenosis,plaque,hardening strength ratings are[1(1,1)],and the differences were statistically significant with the control group(P<0.05).Conclusion:Rosuvastatin and simvastatin play a role in the treatment of elderly patients with lower limb arteriosclerosis disease,but rosuvastatin effect is ideal.Its lipid levels and endometrial thickness,arterial stenosis,plaque,hardening intensity scores improve significantly.%目的:观察瑞舒伐他汀与辛伐他汀治疗老年人下肢动脉硬化疾病的临床效果。方法:收治老年人下肢动脉硬化疾病患者65例,分两组,试验组选择瑞舒伐他汀治疗,对照组选择辛伐他汀治疗。结果:试验组治疗后 TC、TG、HDL-C、LDL-C、hs-CRP均出现明显的改善趋势,其治疗后下肢动脉内膜厚度、动脉狭窄、斑块、硬化强度评分均为[1(1,1)],与对照组治疗后比较差异有统计学意义(P<0.05)。结论:瑞舒伐他汀与辛伐他汀在老年人下肢动脉硬化疾病治疗中均能发挥一定的作用,但瑞舒伐他汀效果较为理想,其血脂水平与下肢动脉内膜厚度、动脉狭窄、斑块、硬化强度评分改善明显。

  17. Treatment of acute arterial ischemia in lower extremity elderly patients with arteriosclerosis stenosis by surgery combined with endovascular%手术联合腔内治疗合并动脉硬化的急性下肢动脉缺血23例临床观察

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    卢辉俊; 赵翼; 胡亚立; 刘辉

    2011-01-01

    目的:探讨手术联合腔内的方法治疗合并动脉硬化狭窄的急性下肢动脉缺血高龄患者的技术要点及疗效.方法:回励性分析2008年9月-2010年9月收治的23例(26肢)合并动脉硬化的下肢动脉缺血高龄患者DSA下行腔内联合手术治疗的临床资料和治疗效果.结果:26条肢体(23例)经双腔Fogarty导管取栓、动脉内膜剥脱术,并行相应球囊扩张加支架置入术,或辅助人工血管旁路手术或/和自体静脉补片成形术,救治成功20例(87.0%),截肢1例(4.3%),死亡2例(8.7%).结论:伴有全身动脉粥样硬化的大多数动脉缺血高龄患者,手术联合腔内的个体化治疗方案,有助于提高重建下肢动脉供血的救治率.%Objectives To explore the clinical results and technical outlines of individualism surgery combined with endovascular in treating acute arterial ischemia in lower extremity elderly patients with arteriosclerosis stenosis. Methods: Datas of 23 acute arterial ischemia in lower extremity elderly patients with arteosclerosis stenosis receiving DSA or C-arm machine comprehensive therapy under monitoring from September 2008 to September 2010 were analyzed. Result: The extremities were saved successfully through active measures. 23 limbs in 21 cases were salvaged after underwent embolectomy by using Thru-lumen embolectomy catheters , endartere -ctomy, balloon expansion and stent implantation,or/and bypass graft surgery and autologous vein patch an-gioplasty. 21 patients were cured(87.0%). One patient was amputated(4.3%). One patient died of multiple organ failure, and the other died of unknown factor (8.7%). Conclusions; Combination surgery and endovascular therapy individualistically achieves a high success rate in treating acute arterial ischemia in lower extremity elderly patients with arteriosclerosis stenosis. Final outcome depends on the right operation and proper management of complications.

  18. Avaliação funcional durante o exercício em crianças e adolescentes com bronquiolite obliterante pós-infecciosa Functional capacity assessment during exercise in children and adolescents with post-infectious bronchiolitis obliterans

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    Rita Mattiello

    2008-08-01

    Full Text Available OBJETIVO: Avaliar a capacidade funcional no exercício em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. MÉTODOS: Foram estudadas 20 crianças com bronquiolite obliterante pós-infecciosa, com idade de 8 a 16 anos, que estavam em acompanhamento ambulatorial. Os pacientes realizaram teste cardiopulmonar do exercício (TCPE em esteira, teste de caminhada de 6 minutos (TC6, espirometria e pletismografia, seguindo diretrizes da American Thoracic Society (ATS, European Respiratory Society (ERS e American College of Chest Physicians (ACCP. Para o cálculo dos percentuais esperados, foram utilizados Armstrong (TCPE, Geiger (TC6, Knudson (espirometria e Zapletal (pletismografia. RESULTADOS: A idade média foi de 11,4±2,2 anos; 70% meninos; peso: 36,8±12,3 kg; altura: 143,8±15,2 cm. Os pacientes apresentaram os fluxos diminuídos na espirometria e os volumes aumentados na pletismografia, comparados com a população de referência. No TCPE, 11 pacientes apresentaram valores do consumo de oxigênio (VO2 de pico reduzidos (OBJECTIVE: To assess functional capacity during exercise in children and adolescents with post-infectious bronchiolitis obliterans (PIBO. METHODS: 20 children with PIBO, aged 8-16 years old, and in follow-up at an outpatient clinic carried out cardiopulmonary exercise testing (CPET, a 6-minute walk test (6MWT and pulmonary function tests (PFT, according to American Thoracic Society (ATS, European Respiratory Society (ERS and American College of Chest Physicians (ACCP guidelines. Results were expressed as percentages of predicted reference values: Armstrong's for CPET, Geiger's for 6MWT, Knudson's for spirometry, and Zapletal's for plethysmography. RESULTS: Mean age (± SD was 11.4±2.2 years; 70% were boys; mean weight: 36.8±12.3 kg; mean height: 143.8±15.2 cm. When compared to reference values, PFT detected lower airflows (spirometry and higher volumes (plethysmography. Eleven patients had reduced peak VO2

  19. The effectiveness of endovascular revascularization for atherosclerosis obliterans in lower extremity:a 2-year experience%下肢动脉硬化闭塞症腔内治疗的疗效分析及2年内的随访观察

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    殷晓丽; 畅智慧; 王秋实; 刘兆玉

    2013-01-01

    Objective: To determine the efficacy, safety, and 2—year outcome, including patency and limb salvage, of en-dovascular revascularization in patients with lower extremity atherosclerosis obliterans. Methods: From July 2006 to June 2011, 274 limbs in 222 patients with lower extremity atherosclerosis obliterans were treated by endovascular revascularization. There were 162 males and 60 females, with the mean age of 67.5±11.2 years old. Ninty-two limbs in the aorta-iliac group, 101 limbs in the infrainguinal group, 31 limbs in the infra-popliteal group, and 50 limbs in multiple segment group. The most common presenting symptom was severe intermittent claudication(Rutherford 3, n=116), followed by rest pain (Rutherford 4, n= 87), non -healing ulcer (Rutherford 5, n=37) and gangrene (Rutherford 6, n=34). Patency was evaluated by using ultrasound scanning, CTA or DSA if necessary, and follow-up status was evaluated with the Kaplan-Meier method. Results: Immediate procedural and clinical success were achieved in 269 and 265 limbs respectively. Eighty-six limbs underwent angioplasty, while the rest 183 limbs underwent angioplasty plus stent placement. There were four perioperative death, and two major amputations within the first 30 days. Mean follow-up was 20.8±4.7 months (range, 9-75 months). Two hundred and thirty-five limbs had effective follow-up. Primary patenty rate, secondary patenty and limb salvage rate at 2 years were 71.5%, 75.7%, and 96.2%, respectively. Conclusion: Endovascular revascularization is a feasible, safe, and effective procedure for the treatment of lower extremity atherosclerosis obliterans.%目的:探讨腔内治疗的疗效及2年内的随访结果.方法:回顾性分析我院2006年7月-2011年6月的222例下肢动脉硬化闭塞症患者的资料,共274条患肢.本组病例中男162例,女60例,平均年龄(67.5±11.2)岁.根据不同的病变部位分为:主髂动脉病变92条肢体,股腘动脉101条肢体,膝下动脉31

  20. Therapeutic effects of Lipo-prostaglandin E1 injection on coronary heart disase complicated wripheral arteriosclerosis obliteration%前列地尔脂微球载体注射液治疗冠心病并闭塞性周围动脉粥样硬化的疗效

    Institute of Scientific and Technical Information of China (English)

    刘倩倩; 查滨; 温亮; 杨庆辉; 陈延军

    2012-01-01

    Objective: To investigate efficacy and safety of intravenous injection of Lipo - prostaglandin El (Lipo-PGE1) treating coronary heart disease (CHD) complicated peripheral arteriosclerosis obliteration (PAO). Methods : A total of 49 CHD patients with PAO were divided into routine treatment group (n = 22) and Lipo-PGE1 group (received Lipo-PGEl intravenous injection 10 μg/d based on routine treatment for 14d). At the beginning and 14d after treatment, all patients underwent 6-min walking test (6MWT). Bruce treadmill exercise test for examining METs, echocardiography and ankle/brachial index (ABI) etc were measured. Results; Compared with routine treatment group after treatment, there were significant increase in 6MWT [ (324.8 ± 65.5) m vs. (358.2 ± 76. 7) m], METs[ (3.5±0.9) vs. (4.3±1.3)] and ABI [ (0.901 ±0. 02) vs. (1.079 ±0.05)], and significant decrease in homocystine (Hey) level [ (16. 8+ 1. 91) μnol/L vs. (10. 7± 0. 55) μmol/L] in Lipo- PGE1 group, P<0. 05 all. No patients exited because of severe adverse reactions. Conclusions: Lipo-PGEl intravenous injection based on routine treatment can improve ankle/brachial index, exercise tolerance and Hey levels in CHD patients complicated peripheral arteriosclerosis obliteration, and it possesses good tolerance and safety.%目的:观察静脉注射前列地尔脂微球载体( Lipo- PGEI)注射液治疗冠心病合并闭塞性周围动脉粥样硬化(PAO)的有效性和安全性.方法:入选49例冠心病合并PAO患者,分为常规治疗组(22例)和前列地尔治疗组(27例,在常规治疗基础上给予Lipo-PGE110μg/d,静脉注射,连用14d),分别于治疗开始及14 d时进行6 min步行距离试验(6MWT)、Bruce运动平板试验[测代谢当量(MET)]、超声心动图、踝/肱指效(ABI)及血清标记物检查.结果:与常规治疗组治疗后比较,前列地尔组6MWT[ (324.8±65.5)m比(358.2±76.7)m]、METs[ (3.5±0.9)比(4.3±1.3)]、ABI[(0.901±0.02)比(1.079±0.05)]明显增

  1. 血管腔内介入联合负压闭式引流术治疗糖尿病足合并下肢动脉硬化闭塞症%Percutaneous transluminal angioplasty and vacuum sealing drainage for patients with diabetic foot and arteriosclerosis obliteration of the lower extremity

    Institute of Scientific and Technical Information of China (English)

    姜国忠; 李蕾; 刘巍立; 赵健飞; 魏福庆; 鹿凯

    2016-01-01

    Objective To study the clinical efficacy of percutaneous transluminal angioplasty (PTA) and vacuum sealing drainage technique on patients with diabetic foot and arteriosclerosis obliteration of the lower extremity.Methods Sixty-four patients were divided into two groups.Group A (32 patients) were treated by traditional methods,while 32 patients in Group B treated by vacuum sealing drainage technique in addition to percutaneous transluminal angioplasty.Results One week after surgery,ABI in group A was 0.53 ±0.17 vs 0.85 ±0.27 in group B,P =0.00.Ulcer healing rate increased from 31.25% in group A to 81.25% in group B,P <0.01.The amputation rate decreased from 56.25% in group A to 18.75% in group B,P =0.00.Claudication distance extended and ulcer recurrence rate in group A was 40%,while in group B it was 0,P =0.00.Conclusion The combination of PTA and vacuum sealing drainage significantly improves the prognosis of patients with diabetic foot and arteriosclerosis obliteration of the lower extremity.%目的 探讨血管腔内介入联合负压闭式引流术治疗糖尿病足合并下肢动脉硬化闭塞症患者的临床疗效.方法 糖尿病足合并下肢动脉硬化闭塞症患者64例,传统治疗组(A组)32例,血管腔内介入联合负压闭式引流术治疗组(B组)32例,对结果采用x2检验、t检验检测2组的踝肱指数以及与溃疡愈合相关的指标,并观察肉芽组织生长情况.结果 A组踝肱指数治疗后(0.53 ±0.17)比治疗前(0.42±0.19)升高,B组踝肱指数治疗后(0.85±0.27)比治疗前(0.36±0.15)也升高,B组优于A组,差异有统计学意义.与A组比较,B组肉芽组织生长良好,溃疡愈合天数明显缩短[A组:(68±22)d;B组:(36±15)d],愈合率显著提高(A组:31.25%;B组:81.25%),截肢率降低(A组:56.25%;B组:18.75%),1年后跛行距离延长[A组:(333±125) m;B组:(611±213)m],溃疡复发率降低(A组:40%;B组:0).结论 血管腔内介入联合负压闭式引流治疗能显著

  2. Bronquiolite obliterante: perfil clínico e radiológico de crianças acompanhadas em ambulatório de referência Bronquiolitis obliterante: perfil clínico y radiológico de 35 niños acompañados en ambulatorio de referencia Bronchiolitis obliterans: clinical and radiological profile of children followed-up in a reference outpatient clinic

    Directory of Open Access Journals (Sweden)

    Carolina Arcanjo Lino

    2013-03-01

    los pediatras frente a lactantes silbadores graves y perennes.OBJECTIVES: To describe the clinical and radiological characteristics of patients with bronchiolitis obliterans. METHODS: This is a retrospective and descriptive study. Data were collected from patients diagnosed with bronchiolitis obliterans between 2004 and 2008 in the Pediatric Pulmonology Clinic of Hospital Infantil Albert Sabin, in Ceará, Northeast Brazil. Such diagnosis was based on clinical and tomographic criteria. Previous history, clinical findings at the diagnosis, complementary exams, and follow-up data were evaluated. RESULTS: 35 children diagnosed with bronchiolitis obliterans were identified. There was a predominance of male patients (3:1. The mean age at the onset of symptoms was 7.5 months, and bronchiolitis obliterans was diagnosed at a mean age of 21.8 months. The most common clinical findings were crackles/wheezing, tachypnea, dyspnea, and chest deformity. Post-infectious etiology was the main cause of bronchiolitis obliterans. Predominant findings at chest X-ray and high resolution computed tomography were peri-bronchial thickening and mosaic pattern, respectively. The treatment was variable and individualized. The majority of patients improved during follow-up, despite the persistence of respiratory symptoms. CONCLUSIONS: In this study, the predominance of male patients and post-infectious etiology was noted, corroborating scientific literature. The most common tomographic findings were similar to those described in previous studies (mosaic pattern, peri-bronchial thickening, and bronchiectasis. Evidence about the treatment of this disease is still lacking. The diagnosis was delayed, which indicates that clinical suspicion of bronchiolitis obliterans is necessary in children with persistent and severe wheezing.

  3. An Approach to Relativity of the Lower Extremity Atherosclerosis Obliterans Syndrome Differentiation Typing and Endothelial Function%下肢动脉硬化闭塞症辨证分型与血管内皮功能相关性探讨

    Institute of Scientific and Technical Information of China (English)

    李建鹏; 王峥

    2011-01-01

    Objective:To research the relativity of the lower extremity atherosclerosis obliterans (ASO) syndrome differentiation typing and endothelial function.Methods: 161 cases of ASO in various typings based on syndrome differentiation were observed, the endothelial function indexes were detected.SPSS11.5 for windows software was adopted for statistical treatment.Results :ASO patients had severe endothelial dysfunction(ED) ,ET- 1 and TXB2 in blood plasma of Damp -heat pouring down syndrome group were significantly higher than other groups' s( P < 0.01 ), and the same result to Blood stasis syndrome group' s.But NO in blood serum and 6 - Keto - PGF1α in blood plasma of Damp - heat pouring down syndrome group and Blood stasis syndrome group were significantly lower than Yin -cold congealing syndrome group and Spleen- kidney yang deficiency syndrome group's(P < 0.05 )Conclusion: With respect to the severity of ED, Damp - heat pouring down syndrome group is highest, Blood stasis syndrome group take second place, Yin -cold congealing syndrome group and Spleen -kidney yang deficiency syndrome group is lower.%目的:探讨不同证型的下肢动脉硬化闭塞症(ASO)与血管内皮功能的相关性.方法:选择ASO患者共161例,经辨证后检测各证型患者血管内皮功能指标,采用SPSS 11.5软件包对数据进行统计学处理.结果:ASO患者存在较为严重的血管内皮功能障碍(ED),湿热下注证组患者血浆ET-1、TXB2水平高于其它证型组(P<0.01),血脉瘀阻证为其次;而血清NO水平在此两证型中低于阴寒结聚证及脾肾阳虚证(P<0.05).结论:下肢动脉硬化闭塞症(ASO)湿热下注证血管内皮功能障碍(ED)最为严重,其次为血脉瘀阻证,阴寒结聚证及脾肾阳虚证内皮功能障碍相对较轻.

  4. Effects of hirudo capsules on platelet activation and blood rheology in patients with cerebral arteriosclerosis%水蛭对脑动脉硬化症患者血小板活化及血液流变学的影响

    Institute of Scientific and Technical Information of China (English)

    闻绍云; 陈秋月; 张丹红

    2014-01-01

    activation and blood rheology in patients with cerebral arteriosclerosis. Methods 122 patients with cerebral arteriosclerosis were randomly divided into two groups by the random number table:observation group(61 cases)and control group (61 cases). The two groups received conventional treatment such as antihypertensive and hypoglycemic drugs,and 100 mg of aspirin once a day. In the observation group,additionally hirudo capsules 0.75 g,3 times a day were given. The therapeutic course in both groups was 2 months. Prior to the start of treatment and on the next day after the end of treatment,traditional Chinese medicine(TCM)clinical syndrome integral,platelet membrane glycoproteins caspase 1 (PAC-1),platelet adhesion molecule P selection(CD62P)positive rate,and blood rheology indexes were detected,in addition to the adverse reactions . Results Before treatment,there were no statistical significant differences between the two groups in terms of TCM clinical syndrome integral such as headache,dizziness,head fullness,multiple somnolence amnesia,lip dark purple,sublingual veins purple in color,PAC-1,CD62P positive rate,hemorheology indexes(all P>0.05). After treatment,TCM clinical syndrome integral PAC-1,CD62P,low shear viscosity,high shear viscosity,plasma viscosity and the hematocrit of two groups were significantly lower than those before treatment, the improvement in observation group being more remarkable〔headache:0.75±0.69 vs. 1.23±0.92,dizziness:0.96±0.78 vs. 1.54±1.24,head fullness:0.65±0.59 vs. 1.48±1.17,multiple somnolence amnesia:0.77±0.72 vs. 1.69±1.14,lip dark purple:0.83±0.81 vs. 1.32±0.79,sublingual veins purple:0.84±0.67 vs. 1.20±0.74, PAC-1:(10.31±4.57)%vs.(15.13±6.27)%,CD62P:(11.39±5.24)%vs.(16.40±7.91)%,low shear viscosity (mPa�s):7.52±3.37 vs. 8.97±3.50,high shear viscosity(mPa�s):4.35±1.12 vs. 5.58±1.19,plasma viscosity (mPa�s):1.54±0.35 vs. 1.88±0.42,hematocrit(HCT):0.43±0.09 vs. 0.49±0.10〕. In the patients' follow-up, there

  5. 髂外-腘动脉人工血管交叉转流术治疗髂股动脉硬化闭塞症%External iliac-popliteal artery artificial graft cross bypass for the treatment of arterial occlusion in lilac-femoral arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    马杰; 马韬

    2009-01-01

    Objective To study the curative effectiveness of external iliac-popliteal artery artificial graft cross bypass in treating extensive arterial occlusion in unilateral lilac-femoral arteriosclerosis. Methods From Sep. 1999 to Oct. 2007, 39 elder patients were diagnosed as having extensive arterial occlusion in unilateral lilac-femoral arteriosclerosis by color Doppler ultrasonography, CTA or DSA. 25 patients (61.5%) had resting pain, 14 had ulcers or gangrenes in the toes. The average ankle-brachial index was 0. 19. Contralateral external iliac-popliteal artery artificial graft cross bypass surgeries were performed on 22 patients from left to right, the other 17 were from right to left. Results There were no perioperative death or amputation. The ankle-brachial index increased from 0 ~ 0. 41 ( preoperative ) to 0. 85 ~ 1.02(postoperative) ; the claudication distance increased from 15 ~ 60 m (preoperative) to 350 ~ 500 m or more than 500 m [ postoperatively at the speed of (100 ~ 120) m/min] ; The postoperative color Doppler uhrasonography showed the average velocity of the popliteal artery was 45 cm/s. In the anterior tibial artery or the posterior tibial artery, little blood flow was showed in preoperative color Doppler ultrasonography examination, the postoperative average blood flow velocity was 41 cm/s. 35 patients (89. 7% ) were followed up for an average of 3.4 years, with an accumulative patency rate of 85.7%. Four patients had amputation, the limb salvage rate is 88.6%. Conclusion External iliac-popliteal artery artificial graft cross bypass is effective in treating unilateral lilac-femoral arterial occlusion, particularly for aged patients with vital organ incompetence.%目的 探讨髂外动脉-腘动脉人工血管移植交义转流术治疗单侧髂股动脉硬化广泛性闭塞的疗效.方法 1999年9月至2007年10月39例患者经血管彩超、CT血管造影(CTA)或数字减影血管造影(DSA)检查,证实单侧髂股动脉

  6. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.

    Science.gov (United States)

    Cheng, Bo; Anea, Ciprian B; Yao, Lin; Chen, Feng; Patel, Vijay; Merloiu, Ana; Pati, Paramita; Caldwell, R William; Fulton, David J; Rudic, R Daniel

    2011-10-11

    The suprachiasmatic nucleus of the brain is the circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues to control circadian physiology. As such, central clock dysfunction can alter systemic homeostasis to consequently impair peripheral physiology in a manner that is secondary to circadian malfunction. To determine the impact of circadian clock function in organ transplantation and dissect the influence of intrinsic tissue clocks versus extrinsic clocks, we implemented a blood vessel grafting approach to surgically assemble a chimeric mouse that was part wild-type (WT) and part circadian clock mutant. Arterial isografts from donor WT mice that had been anastamosed to common carotid arteries of recipient WT mice (WT:WT) exhibited no pathology in this syngeneic transplant strategy. Similarly, when WT grafts were anastamosed to mice with disrupted circadian clocks, the structural features of the WT grafts immersed in the milieu of circadian malfunction were normal and absent of lesions, comparable to WT:WT grafts. In contrast, aortic grafts from Bmal1 knockout (KO) or Period-2,3 double-KO mice transplanted into littermate control WT mice developed robust arteriosclerotic disease. These lesions observed in donor grafts of Bmal1-KO were associated with up-regulation in T-cell receptors, macrophages, and infiltrating cells in the vascular grafts, but were independent of hemodynamics and B and T cell-mediated immunity. These data demonstrate the significance of intrinsic tissue clocks as an autonomous influence in experimental models of arteriosclerotic disease, which may have implications with regard to the influence of circadian clock function in organ transplantation.

  7. Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.

    Directory of Open Access Journals (Sweden)

    Hiroki Tanaka

    Full Text Available Abdominal aortic aneurysm (AAA is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.

  8. Study on the relationship of serum sP-selectin and hs-CRP with carotid arteriosclerosis in patients with acute ischemic stroke%急性缺血性卒中患者血清可溶性P-选择素、hs-CRP水平与颈动脉粥样硬化关系的研究

    Institute of Scientific and Technical Information of China (English)

    冯秋菊; 刘振伟; 万琦

    2014-01-01

    Objective It is tO investigate the assOciatiOn between levels Of serum sP -selectin,hs -CRP and extracranial carOtid arteriOsclerOsis in patients with acute ischemic strOke. Methods 120 inpatients with acute ischemic strOke attacking within 72 hOurs were selected and the serum sP-selectin,hs-CRP were measured by ELISA. A cOlOr DOppler ultrasOund sys-tem was used tO detect the plaque Of carOtid artery. Results The serum cOncentratiOns Of sP-selectin were different when the intima-media thickness Of ECCA,the nature Of plaque and the level Of carOtid artery stenOsis were different(P 0. 05). Conclusion The severer ex-tracranial carOtid atherOsclerOsis is the higher the serum cOncentratiOns Of sP -selectin are in acute ischemic strOke patients. There is a pOsitive relatiOnship between serum sP-selectin and carOtid atherOsclerOsis,and the activity is mOre sensitive than Hs-CRP in the detectiOn Of carOtid atherOsclerOsis.%目的:研究急性缺血性卒中患者血清可溶性 P-选择素( sP-selectin)、高敏 C反应蛋白( hs-CRP)水平与颈动脉粥样硬化程度的关系。方法选择发病72 h 内急性脑梗死患者120例,采用ELISA法测定患者血清sP-selectin及hs-CRP浓度,并应用颈动脉超声对斑块特点进行分析。结果不同颈总动脉内-中膜厚度、不同颈动脉斑块性质、不同颈动脉狭窄程度时,sP-selectin水平存在显著性差异( P<0.05);随着颈总动脉内-中膜厚度越厚,颈动脉斑块稳定性越差,颈动脉狭窄程度越重,sP -selectin 水平越高,而 hs -CRP 差异不显著。结论急性缺血性卒中患者sP-selectin水平随着颅外段颈动脉粥样硬化程度加重而升高,sP-selectin与动脉粥样硬化呈正相关;且较 hs-CRP更好地反映了颈动脉粥样硬化的程度。

  9. Bronchiolitis obliterans organizing pneumonia during low-dose amiodarone therapy

    NARCIS (Netherlands)

    Jessurun, GAJ; Hoogenberg, K; Crijns, HJGM

    1997-01-01

    Two cases of amiodarone-induced pulmonary toxicity during a relatively short period of low-dose amiodarone treatment are reported. The toxicity risk of amiodarone is determined by cumulative factors in individual patients.

  10. Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT

    DEFF Research Database (Denmark)

    Holm, A M; Riise, Gerdt; Hansson, Leif Helmuth

    2013-01-01

    and Finland were recorded and compared with survival data from the Scandiatransplant registry. In total, LTx after allo-SCT had been performed in 13 patients. Allo-SCT was done because of AML (n=6), CML (n=3), ALL (n=2), immunodeficiency (n=1) and aplastic anemia (n=1). All developed clinical c...

  11. Osteonecrosis of Femoral Head Occurred after Stent Placement of Femoral Artery

    Directory of Open Access Journals (Sweden)

    Akiyoshi Shimatani

    2014-01-01

    Full Text Available We present a case of osteonecrosis of femoral head (ONFH that occurred after stent angiography of femoral artery for the treatment of arteriosclerosis obliterans (ASO of left inferior limb in a 76-year-old woman. No case of late collapse of femoral head as a complication of endovascular procedure such as stent placement has been previously documented. We considered that ONFH occurred after detaining stent at a junction of left deep femoral artery for the treatment of the ischemia of left lateral and medial femoral circumflex artery.

  12. Laser Biostimulation Of Wound Healing In Arteriopatic Patients

    Science.gov (United States)

    Tallarida, G.; Baldoni, F.; Raimondi, G.; Massaro, M.; Peruzzi, G.; Bertolotti, M.; Ferrari, A.; Scudieri, F.

    1981-05-01

    Low-power laser irradiation has been employed in the attempt to accelerate the wound-healing of ischemic cutaneous ulcerations with threatening or manifest gangrene due to arteriosclerosis obliterans of the lower limbs. Irradiation was performed by using a low-power He-Ne gas laser of 6328 Å wavelength and was concentrated at the peripheral zone of the lesions. The preliminary results of the study indicate that laser stimulation might be new approach in the conservative menagement of the ischemic ulcers in patients with severe peripheral obstructive arteriopaties not suited for arterial reconstruction.

  13. Bilateral brachial pull-through technique for stenting in a patient with stenosis of the vertebral artery origin: technical case report

    Energy Technology Data Exchange (ETDEWEB)

    Kusaka, N.; Nishiguchi, M.; Takayama, K.; Nishiura, T. [National Hospital Organization Iwakuni Clinical Center, Department of Neurosurgery, Iwakuni, Yamaguchi (Japan); Tamiya, T. [Kagawa University of Medicine, Department of Neurological Surgery, Kida-gun, Kagawa (Japan)

    2007-10-15

    Stenting for stenosis of the proximal vertebral artery (VA) is commonly performed via a femoral approach. However, iliofemoral occlusive disease such as arteriosclerosis obliterans sometimes prevents safe transfemoral access. In certain situations where both femoral access and ipsilateral brachial access are difficult because of a concomitant vascular diseases or particular anatomic setting, a contralateral brachial approach using the brachiobrachial pull-through technique may allow efficient and accurate stenting. A case of VA origin symptomatic stenosis successfully treated with stenting using the new pull-through technique from the contralateral brachial artery to the brachial artery on the affected side is described. (orig.)

  14. 反义细胞外信号调节激酶-2基因治疗移植物动脉血管病内膜病变%The effect of adenovirus-mediated anti-extracellular signal regulated kinase 2 gene therapy on intimal change in transplant arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    赵波; 宫念樵

    2011-01-01

    目的 观察移植物动脉血管病(TA)的内膜病变机制和反义细胞外信号调节激酶2基因腺病毒载体(Adanti-ERK2)基因治疗的效果.方法 建立Brown-Norway(BN)-Lewis移植物动脉血管病模型,分为同系组、Control组、LacZ组和Adanti-ERK2组(给予5×109 pfu Adanti-ERK2基因治疗),每组各6例.术后60 d检测各组内膜病变和血管腔内膜/(内膜+中膜)比,α-肌动蛋白(α-actin)和血小板源性生长因子-BB(PDGF-BB)染色检测移植动脉平滑肌细胞(VSMCs)增殖和分泌功能,评估移植动脉新生毛细血管情况并检测移植动脉中环氧化酶-2(COX-2)的表达.结果 术后60 d同系组内膜无异常,Control组和LacZ组典型内膜增殖改变,Adanti-ERK2组内膜病变较轻;内膜/(内膜+中膜)比各组分别为7.6%、81.4%、85.9%、15.9%;α-actin阳性细胞(内膜平滑肌细胞)每视野计数各组分别为0、71.3±9.2、76.4±11.3、34.8±5.3;PDGF-BB阳性细胞每视野计数各组分别为0.9±0.5、28.4±3.4、29.1±3.2、8.6±1.7;移植动脉中膜和内膜新生毛细血管检测各组分别无、丰富、丰富、少量;COX-2新生血管阳性细胞计数各组分别为0、36.3±8.3、40.9±9.2、10.4±3.9.Adanti-ERK2组与其他组别间比较,差异有统计学意义(P<0.05).结论 内膜增生,血管腔缩窄,PDGF-BB诱导内膜平滑肌细胞募集分化并激发血管新生是TA重要病理生理环节,AdantiERK2基因治疗可有效干预各发病环节,达到治疗效果.%Objective To explore the mechanisms of intimal injury underlying transplant arteriosclerosis (TA) and to clarify the treatment effect of adenovirus-mediated anti-extracellular signal regulated kinase 2 (Adanti-ERK2) gene therapy on TA. Methods The Brown-Norway (BN)-Lewis TA model was employed. According to different gene therapy, the recipients were divided into isograft group, control group, LacZ group, which were used as control, and Adanti-ERK2 group (5 × 109 pfu Adanti-ERK2 was transferred

  15. Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke Arteriosclerosis y nuevas perspectivas de los inhibidores del receptor GPIIb/IIIa en stroke

    Directory of Open Access Journals (Sweden)

    GUSTAVO SAPOSNIK

    2000-03-01

    Full Text Available Ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. Antiplatelets agents did show benefit in secondary prevention. Aspirin is the most common antiaggregant in clinical use today. However, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. The adherence of circulating platelets to the subendothelium is mediated by glycoprotein (GP residing on the cell's surface. GPIIb/IIIa is the most important platelet membrane receptor that mediates the process of platelet aggregation, and thrombus formation. Thus, new drugs that block the GPIIb/IIIa receptor have recently emerged. Clinical trials using these agents have shown effectiveness in acute coronary syndromes. However, the absence of studies in cerebrovascular disease and the potential hemorrhagic complications questioned their use in stroke prevention. We review the clinical trials using the new GPIIb/IIIa agents in myocardial ischemia, and consider the potential implications for cerebrovascular disease.Los mecanismos de isquemia en infarto de miocardio y enfermedad cerebrovascular (ECV han sido estudiados por mas de 150 años. Drogas antiplaquetarias mostraron un beneficio en la prevención secundaria. La aspirina es el mas común de los antiagregantes usados en la practica clínica. No obstante, el beneficio producido, aun con el "mejor" tratamiento antiagregante, en la prevención de ECV es inferior al 40%. La adhesión plaquetaria es un proceso mediado por glicoproteinas (GP de la membrana celular. GPIIb/IIIa es un receptor de membrana plaquetaria que interviene en el proceso de agregación plaquetaria y formación del trombo. Estudios clínicos con nuevos agentes que bloquean a este receptor mostraron ser efectivos en los síndromes coronarios agudos. No obstante, la falta de estudios en ECV y las potenciales complicaciones hemorrágicas, limitan su uso en la prevención de stroke. Revisamos los mecanismos de trombogenésis y los estudios clínicos con los nuevos agentes GPIIb/IIIa, considerando sus implicancias en ECV.

  16. Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine.

    Science.gov (United States)

    Inoue, Hajime; Aihara, Masaki; Tomioka, Miyuki; Watabe, Yu-ichi

    2013-01-01

    Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly increased the VEGF contents in an ischemic ear; 2) Treatment with alprostadil resulted in strongly expressed VEGF levels only in the ischemic region; 3) Image analysis revealed a significant increase in the number of vessel bypasses and paths after flap creation with alprostadil administration compared to the vehicle-treated ears. The results suggest that it may be possible to apply alprostadil as one device for regenerative medical technology.

  17. Origin of vascular smooth muscle cells and the role of circulating stem cells in transplant arteriosclerosis

    NARCIS (Netherlands)

    Hillebrands, JL; Klatter, FA; Rozing, J

    2003-01-01

    To date, clinical solid-organ transplantation has not achieved its goals as a long-term treatment for patients with end-stage organ failure. Development of so-called chronic transplant dysfunction (CTD) is now recognized as the predominant cause of allograft loss long term (after the first postopera

  18. Impact of arteriosclerosis on the functioning of arteriovenous fistula for hemodialysis

    Directory of Open Access Journals (Sweden)

    Stolić Radojica

    2007-01-01

    Full Text Available Background/Aim. Numerous clinical studies have shown that the incidence of artheriosclerosis is higher in patients with progressive renal insufficiency. The aim of this study was to examine the incidence of artheriosclerosis in patients on chronic hemodialysis and its influence on survival and functioning of vascular access. Methods. The study was organized as one-year prospective study. All the patients had arteriovenous fistulas native as a vascular access. The study analyzed demographic, biochemical, clinical and Doppler echomorphological characteristics of the patients in order to make an evidence of artheriosclerotic incidences as compared to functioning arteriovenous fistulas for hemodialysis. Results. The examined patients were of the mean age 55.7±12.68 years. Of them, 53.8% were males and 46.2% females. Functioning arteriovenous fistulas for haemodialysis were found in 56.8% of the examined patients. Concentration of hemoglobin was a significant parameter of functioning fistula (group with complications - 89±14.034 vs. group with no complications - 96.6±17.71; p = 0.0489. An amount of urea removed (URR was a statistically more significant parameter among the patients without fistula complications: (group with complications - 58.67±7.92% vs. group with no complications - 62.80±7.53%; p = 0.037. A Cox regressive analysis of an index of Doppler parameters of the carotid arteries found no statistical significance between the examined groups. There was a positive correlation between artheriosclerosis and the age, as well as the time on dialysis. In multiple regression, where intima media is a dependent and the age and time on dialysis independent variables, the regressive model was statistically significant (F = 8.22, p = 0.001. Both independent variables had statistically significant inclinations, p < 0.01. Conclusion. Anemia and the level of urea elimination, as a statistically significant indicator of hemodialysis adequacy, were in correlation with the risk for fistula complications. B-mode ultrasonography of the carotid arteries is a significant non-invasive method for detecting artheriosclerosis. Intima- media thickness of the carotid arteries was an important marker of artheriosclerosis correlating significantly with the age and time on dialysis, but not with the traditional risk factors.

  19. Minimal distal pressure rise after reconstructive arterial surgery in patients with multiple obstructive arteriosclerosis

    DEFF Research Database (Denmark)

    Noer, Ivan; Tønnesen, K H; Sager, P

    1980-01-01

    fifteen had ischemic ulcers. The preoperative median pressure index (per cent of arm systolic pressure) was 10% on the 1st toe. At the 10th postoperative day the median toe pressure rose to 25%. A further rise took place at the one month control to 30% which was unchanged throughout the study. All...... patients with a persistent postoperative toe pressure above 20% of arm systolic pressure were ultimately relieved from rest pain and chronic ulcers....

  20. Relationship between non-dipper hypertension and arteriosclerosis in the elderly

    Institute of Scientific and Technical Information of China (English)

    陈策

    2014-01-01

    Objective To investigate the influence of non-dipper blood pressure rhythm on peripheral atherosclerosis in elderly hypertensive patients.Methods The 199 elderly hypertensive patients with 24-hour average systolic blood pressure<140 mmH g were selected.Body mass index(BMI),glycosylated hemoglobin,blood lipids,uric acid,creatinine,Brachial ankle pulse wave velocity(ba PWV),ankle arm index(ABI)and 24-hour ambulatory blood pressure monitoring were tested and calculated.The elderly patients were divided into dipper hypertensive group(n=95),and non-dipper hypertensive

  1. Overexpression of ABCG1 protein attenuates arteriosclerosis and endothelial dysfunction in atherosclerotic rabbits

    Directory of Open Access Journals (Sweden)

    Martin Ungerer

    2012-06-01

    Full Text Available The ABCG1 protein is centrally involved in reverse cholesterol transport from the vessel wall. Investigation of the effects of ABCG1 overexpression or knockdown in vivo has produced controversial results and strongly depended on the gene intervention model in which it was studied. Therefore, we investigated the effect of local overexpression of human ABCG1 in a novel model of vessel wall-directed adenoviral gene transfer in atherosclerotic rabbits. We conducted local, vascular-specific gene transfer by adenoviral delivery of human ABCG1 (Ad-ABCG1-GFP in cholesterol-fed atherosclerotic rabbits in vivo. Endothelial overexpression of ABCG1 markedly reduced atheroprogression (plaque size and almost blunted vascular inflammation, as shown by markedly reduced macrophage and smooth muscle cell invasion into the vascular wall. Also endothelial function, as determined by vascular ultrasound in vivo, was improved in rabbits after gene transfer with Ad-ABCG1-GFP. Therefore, both earlier and later stages of atherosclerosis were improved in this model of somatic gene transfer into the vessel wall. In contrast to results in transgenic mice, overexpression of ABCG1 by somatic gene transfer to the atherosclerotic vessel wall results in a significant improvement of plaque morphology and composition, and of vascular function in vivo.

  2. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    Science.gov (United States)

    Campo, Adriaan; Dirckx, Joris

    2014-05-01

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  3. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    Energy Technology Data Exchange (ETDEWEB)

    Campo, Adriaan; Dirckx, Joris [University of Antwerp, Laboratory of Biomedical Physics, Groenenborgerlaan 171 2020 Antwerp (Belgium)

    2014-05-27

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  4. [Smoking and other risk factors of cardiovascular diseases, connected with arteriosclerosis among youth].

    Science.gov (United States)

    Chmiel-Połeć, Zdzisława; Cybulska, Idalia

    2008-01-01

    The World Health Organization (WHO) conference on a "second wave" epidemic of cardiovascular diseases connected with arterial sclerosis (AS) foresee that in 2020 cardiovascular diseases will most likely be the leading cause of death in the world. The development of AS begins in youth and progresses with age. It's intensity depends on the risk factors involved, such as: smoking, hypertension, obesity and fat and sugar disorder in a body. Many of these risk factors, manifesting themselves as diseases in adults, can be found during adolescence. The aim of this study was to establish the spread of smoking and other risk factors of cardiovascular diseases, like: hereditary and increasing incidence hypertension and body mass index (BMI), among youth of upper gymnasium school in Podkarpacie. The research was conducted between November 2007 and March 2008, using 193 volunteer students from upper and lower gymnasium schools, aged between 16-20 years. Our research methods included: diagnostic questionnaire, measurement of blood pressure (BP) through the use of sphygmomanometer, as well as anthropometric measurements including high, weight and body mass estimation. BP was established by obtaining an average between two measurements taken under normal conditions. The results were statistically analyzed, in with the in dependent test chi-Parson square, the level of changes a = 0.05--was used. The research showed that 23.31% of respondents smoke, that's 64.44% girls, and 35.56% boys. 12.41% of the girls and 15.09% of boys smoke on regular basis. And 8.57% girls and 15.09% boys smoke from time to time. More than half of young smokers (51.10%) smoked for longer than 2 years, and the initiations of smoking starts at the age of 15 (26.67%) and the age of 16 (26.67%). 10 and more cigarettes a day smoke 26.67% of boys and 13.79% girls. 75.74% of respondents agree that they are victims of passive smoking. Through 17.61% of respondents (mostly boys 64.70%) we found increasing incidence of hypertension, and 82.35% were related to systolic BP. In the group of people with higher BP systolic hypertension demonstrated itself in 35.72% of positive cases, while diastolic hypertension related to 16.66% of the population and was present mainly among adolescence girls. Most of respondents with higher systolic (75.00%) and diastolic (83.00%) BP were found to be present in those with an obesity problem (50.00%, 10.00%) than in those with correct BMI (12.91%, 5.81%).Hereditary risk factors of AS, from father side, was found among 33.67% of respondents, and mother side, through 23.31% of respondents. Through respondents parents we found quite often: hypertension (fathers 18.65%, mothers 10.36%) and overweight and obesity (fathers 15.03%, mothers 13.99%) also through fathers we found hiperlipidemia (14.51%). Through mothers only, we found cases of diabetes (2.07%) but we didn't find heart stroke cases, which were found through fathers only (2.07%). Among respondents, 43.52% cases, we found one of risk factor of AS and more than half of respondents (56.48%) we found co -existence of 2 and more factors, including: 30.57%--2, 19.18%--3, 5.70%--4, 1.03%--5 risk factors. Through all respondents we found the existence of at least one of the risk factor of AS and through more than half of them, co-existence of two and more risk factors. Hereditary (33.67%--father side, 23.31%--mother side) and smoking (23.31%) were the common risk factors of AS in youth. An increase of hypertension and an increase incidence of BMI were present in (17.61%, 12.43%) respondents.

  5. A case of bronchiolitis obliterans organizing pneumonia (BOOP) after breast conserving therapy for early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Shinya; Kiryuu, Takuji; Maeda, Sunao; Hoshi, Hiroaki; Shimokawa, Kuniyasu [Gifu Univ. (Japan). School of Medicine; Kawaguchi, Shimpei

    2001-03-01

    A case of BOOP occurring after radiotherapy for breast cancer was reported. TBLB and BAL were performed at the time of diagnosis. This case suggested that radiographic changes began in the irradiated area, then later spread to non-irradiated areas. In this article, we discussed the peculiary radiographic image, pathological manifestation, BAL characteristics and clinical course in this sequela. (author)

  6. 儿童闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    王维; 申昆玲

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是1901年德国病理学家Lange首次报道并命名的。从病理学角度,BO被定义为两种类型的支气管损伤:狭窄性细支气管炎和增殖性细支气管炎。从临床意义上讲,BO是一种与小气道炎症损伤相关的慢性气流阻塞综合征。各种因素导致的细支气管上皮细胞和上皮下结构的损伤和炎症,及机体对以上损伤和炎症的不正当修复是BO的发病原因。

  7. A rare case of preputial calculi in a child with balanitis xerotica obliterans: A short communication

    Directory of Open Access Journals (Sweden)

    G.A. Kekre

    2016-09-01

    Full Text Available Preputial stones are the rarest form of urolithiasis in pediatric patients with only a few cases reported in the literature. Following, we present the case of an 11-year-old boy who developed preputial stones.

  8. A rare case of preputial calculi in a child with balanitis xerotica obliterans: A short communication

    OpenAIRE

    2016-01-01

    Preputial stones are the rarest form of urolithiasis in pediatric patients with only a few cases reported in the literature. Following, we present the case of an 11-year-old boy who developed preputial stones.

  9. Direct measured systolic pressure gradients across the aorto-iliac segment in multiple-level-obstruction arteriosclerosis

    DEFF Research Database (Denmark)

    Noer, Ivan; Praestholm, J; Tønnesen, K H

    1981-01-01

    to the angiographic findings. A consistent pressure gradient was found in the various types of arterial occlusions. In patients with occlusion of both the aorta and the iliac arteries, the systolic pressure drop was about 60% (range, 50-78%, SD 9%). The various types of iliac artery occlusions resulted in quite...... uniform systolic pressure drops of about 50% (range 35-68%, SD 9%). In contrast, the systolic pressure drop along different types of iliac stenoses showed a wide variation, ranging from a minimal drop to about 60%. The degree of stenosis on the angiogram was correlated significantly with the pressure drop...

  10. Primary appendiceal adenocarcinoma of colonic type with perforating peritonitis.

    Directory of Open Access Journals (Sweden)

    Noguch H

    2001-10-01

    Full Text Available Primary adenocarcinoma of the appendix is rare, especially the colonic type. We report a case of appendiceal adenocarcinoma of colonic type associated with perforating peritonitis after aorto-femoral artery bypass surgery. A 79-year-old woman presented with fever and pain in the right lower abdomen. She had undergone aorto-femoral artery bypass surgery due to arteriosclerosis obliterans 6 months earlier. Abdominal ultrasonography and computed tomography showed a suspected pool of fluid surrounding the artificial vessel and a mass lesion in the upper end of the fluid collection. These findings suggested localized peritonitis due to appendiceal perforation. Emergency laparotomy showed a pool of pus around the artificial vessel and inflamed appendix, which adhered to the surrounding tissue. The mass was excised in combination with an ileocaecal resection, followed by an ileocolic anastomosis. The histological diagnosis was moderately differentiated adenocarcinoma of the appendix, colonic type. The tumour had infiltrated and obstructed the lumen of the orifice of the appendix, which may have caused perforation of the appendix. She was examined at regular periodic follow-ups and no evidence of recurrence or metastasis was noted in the 12-month postoperative period. These findings indicate that, in cases of acute appendicitis, especially with perforation, the possibility of appendiceal adenocarcinoma should be considered.

  11. Clinical effect of addition of beraprost sodium to pioglitazone treatment on the blood glucose levels in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Chen, T; Kusunoki, M; Sato, D; Tsutsui, H; Nakamura, T; Miyata, T; Oshida, Y

    2013-11-01

    In recent years, the number of patients with type 2 diabetes mellitus caused by insulin resistance has continued to increase in Japan. Insulin resistance is considered to be closely related to the risk of cardiovascular diseases and atherosclerotic diseases, represented by arteriosclerosis obliterans (ASO). Therefore, improvement of insulin resistance is one of the important strategies in the treatment of type 2 diabetes mellitus. At present, α-glucosidase inhibitors, incretin-related drugs, and thiazolidinediones are among the most important oral hypoglycemic drugs used to improve insulin resistance. In this study, the effect of beraprost sodium, a prostaglandin I2 derivative, in the treatment of type 2 diabetes mellitus was investigated. In type 2 diabetic patients with ASO who were under treatment with pioglitazone, additional treatment with beraprost sodium exerted a significant synergistic effect in reducing the serum HbA1c levels as compared to treatment with pioglitazone alone. This result indicates that concomitant administration of pioglitazone and beraprost sodium may be useful in the treatment of diabetes -mellitus.

  12. Platelet scintigraphy in atherothrombotic disease

    Energy Technology Data Exchange (ETDEWEB)

    Isaka, Yoshinari (Osaka National Hospital (Japan))

    1993-01-01

    Indium-111 platelet scintigraphy for the measurement of in vivo thrombogenicity is a useful noninvasive technique with a number of applications. From 1982 to 1989, we explored clinical relevance of this method for 576 consecutive patients with atherothrombotic disease. There was a disease-related difference in the percentage of positive platelet accumulation; 85% in patients with Dacron bifurcation graft, 75% in abdominal or thoracic aneurysm, 40% in intra-cardiac thrombi, 33% in arteriosclerosis obliterans and 25% in ischemic cerebrovascular disease. Labelled platelets accumulated frequently in the lesion with severe arteriographic abnormality. Aspirin clearly inhibited platelet accumulation on carotid atheroma but the effect of ticlopidine has been less conclusive. Short-term orally active PGI[sub 2] analogue had inhibitory effects on platelet accumulation in carotid atheroma and platelet aggregability, but did not cause significant reduction in plaque size. The results suggest the usefulness of platelet scintigraphy for monitoring the thrombogenicity in various atherothrombotic diseases. It will be necessary, however, to simplify the labelling procedures and to develop a new [sup 99m]Tc-labelled thrombus imaging agent, if thrombus imaging is to be considered for more generall use for patients with atherosclerosis. (author).

  13. Cholesterol-Lowering Atherosclerosis Study (CLAS)

    Science.gov (United States)

    2013-12-12

    Arterial Occlusive Diseases; Cardiovascular Diseases; Carotid Artery Diseases; Cerebral Arteriosclerosis; Cerebrovascular Disorders; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Atherosclerosis

  14. Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes

    NARCIS (Netherlands)

    Versluys, A. Birgitta; Rossen, John W. A.; van Ewijk, Bart; Schuurman, Rob; Bierings, Marc B.; Boelens, Jaap J.

    2010-01-01

    Alloimmune lung syndromes (allo-LS), including idiopathic pneumonia syndrome, bronchiolitis obliterans syndrome, and bronchiolitis obliterans organizing pneumonia, are severe complications after hematopoietic stem cell transplantation (HSCT). In our cohort of 110 pediatric patients, 30 had allo-LS (

  15. Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals

    Science.gov (United States)

    Godoi, Emmanuelle Tenório Albuquerque Madruga; Brandt, Carlos Teixeira; Lacerda, Heloisa Ramos; Godoi, Jocelene Tenório Albuquerque Madruga; de Oliveira, Dinaldo Cavalcanti; Costa, Gabriela Farias Araujo Sousa; dos Santos Junior, Gerson Gomes; Leite, Kaliene Maria Estevão; Godoi, Juannicelle Tenório Albuquerque Madruga; de Vasconcelos, Adriana Ferraz

    2017-01-01

    Background The prevalence of atherosclerosis is higher in HIV-positive people, who also experience it earlier than the general population. Objectives To assess and compare the prevalence of atherosclerosis evaluated by the intima-media thickness of carotid and femoral arteries, and by the ankle-brachial pressure index (ABPI) in HIV patients treated or not treated with protease inhibitors (PIs) and controls. Methods Eighty HIV+ subjects (40 using PIs and 40 not using PIs) and 65 controls were included in the study. Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. Classical risk factors for atherosclerosis and HIV were compared between the groups by statistical tests. A p ≤ 0.05 was considered significant. Results An IMT > P75 or the presence of plaque was higher in the HIV+ than in the control group (37.5% vs 19%, p = 0.04). Comparative analysis showed a significant difference (p=0.014) in carotid IMT between HIV+ with PIs (0.71 ± 0.28 mm), without PIs 0.63 ± 0.11 mm and, and controls (0.59 ± 0.11 mm). There was no significant difference in femoral IMT between the groups or in ABPI between HIV+ subjects and controls. However, a significant difference (p=0.015) was found between HIV+ patients not treated with PIs (1.17 [1.08 - 1.23]), and controls 1.08 [1.07 - 1.17]). Conclusion In HIV patients, atherosclerosis is more prevalent and seems to occur earlier with particular characteristics compared with HIV-negative subjects. PMID:28146208

  16. 糖尿病性下肢动脉硬化性闭塞症的治疗选择%Treatment of diabetes arteriosclerosis obliteration

    Institute of Scientific and Technical Information of China (English)

    吴培义; 李承青

    2005-01-01

    目的:探讨糖尿病性下肢动脉硬化性闭塞症的治疗方法.方法:根据64例(71肢)糖尿病性下肢动脉缺血患者肢体术前彩超、动脉造影等检查结果及一般状况,对28条动脉节段性狭窄或闭塞患肢予以动脉旁路架桥、内膜剥脱、经皮血管腔内成型支架置入治疗,对38条下肢动脉广泛闭塞患肢予以静脉动脉化治疗,其中7肢为动脉重建加静脉动脉化,其余12肢以药物及其他治疗.结果:随访6月~10年,除3条截肢外,其余患者缺血症状均有不同程度改善.结论:根据DASO患肢彩超及血管造影结果,选择适当的手术治疗方法,改善肢体缺血状态,是减少病残率的关键.

  17. 下肢血栓闭塞性脉管炎的红外热像图研究%Thermography Study of Lower Extremities Thromboangiitis Obliterans

    Institute of Scientific and Technical Information of China (English)

    汪培清; 郭水英; 陈祺; 冯亚; 吴作干; 汪碧萍

    2002-01-01

    目的分析下肢血栓闭塞性脉管炎的热像图表现,并探讨其诊断价值.方法应用红外热像仪检查47例下肢血栓闭塞性脉管炎患者及21例正常人的双下肢. 结果正常人热图像呈现双下肢皮温无明显差异,大腿与小腿中央呈现淡红色、周边绿色、膝部淡绿色、足背淡兰色.下肢血栓闭塞性脉管炎热图像,患肢温度分布混乱,高温区与低温区温差在0.5℃以上,静脉炎区域高温呈红色,血栓闭塞区域低温呈绿色,足背与足趾低温呈兰色.结论红外热像图能直观显示下肢血栓闭塞性脉管炎的部位并具有一定的诊断价值.

  18. Clinical analysis on 17 patients with bronchiolitis obliterans organizing pneumonia%隐原性机化性肺炎与继发性机化性肺炎

    Institute of Scientific and Technical Information of China (English)

    曹敏; 蔡后荣; 方大楼

    2007-01-01

    目的 了解机化性肺炎(organizing pneumonia,OP)的临床特点、类型、治疗及疗效,初步探讨隐原性机化性肺炎(COP)与继发性OP在临床表现、预后等方面的异同.方法 回顾性分析自2002年7月至2007年4月我院17例OP患者的临床资料.结果 15例为隐原性机化性肺炎,2例为继发于多发性肌炎的机化性肺炎.临床主要表现为咳嗽、进行性活动后呼吸困难,可有发热、盗汗等,肺部闻及爆裂音;影像学表现为双肺多发斑片状肺泡浸润影或线状、网格状影或结节状阴影,肺功能呈限制性通气功能减退,弥散功能降低.肾上腺皮质激素对隐原性机化性肺炎的疗效显著,而对继发于多发性肌炎的机化性肺炎的疗效欠佳.结论 机化性肺炎是一临床病理综合征,易误诊为肺部感染、肿瘤等.隐原性机化性肺炎对肾上腺皮质激素有良好的效果,而继发于多发性肌炎的机化性肺炎临床表现重且预后差.

  19. [The results of combined surgical treatment of thromboangiitis obliterans and critical lower limb ischemia using prolonged epidural analgesia and autohemotherapy with ozone].

    Science.gov (United States)

    Abyshov, N S; Abdullaev, A G; Zakirdzhaev, E D; Guliev, R A; Akhmedov, M B; Tagizade, G T; Zeinalova, G M; Mamedova, L D

    Цель исследования — оценка результатов комбинированного хирургического лечения больных ОТ с КИНК с применением продленной эпидуральной аналгезии и аутогемотерапии с озоном. Материал и методы. Проанализированы результаты лечения 125 больных облитерирующим тромбангиитом с критической ишемией нижних конечностей. Пациенты разделены на две группы: 60 больным (контрольная группа) в периоперационном периоде проводили базисную терапию, включавшую антикоагулянты, дезагреганты, декстраны, препараты метаболического действия, глюкокортикоиды, ангио­протекторы, наркотические и ненаркотические анальгетики. В основной группе (65 человек), наряду с базисной терапией использовали продленную эпидуральную аналгезию и аутогемотерапию с озоном. В ближайшем послеоперационном периоде (до 30 дней) частота выполнения вторичной ампутации голени в основной группе составила 1,5%, в контрольной — 10,0% (p<0,05). Результаты. В основной группе первичное заживление после выполнения «малой» ампутации на стопе наблюдалось у 83,3% больных, в контрольной — у 63,6% (p<0,05), заживление язвенных дефектов на стопе — у 76,2 и 62,2% соответственно (p<0,01). В основной группе удовлетворительный результат лечения достигнут у 80,0%, в контрольной — 61,7% пациентов. Вывод. Выполнение оперативных вмешательств, направленных на восстановление магистрального и мобилизацию коллатерального кровотока, в сочетании с продленной эпидуральной аналгезией и аутогемотерапией с озоном способствует улучшению результатов хирургического лечения и скорейшей реабилитации пациентов с критической ишемией конечности при облитерирующем тромбангиите.

  20. 干燥闭塞性阴茎头炎临床研究进展%Recent advances in the clinical research about balanitis xerotica obliterans

    Institute of Scientific and Technical Information of China (English)

    张羽萌

    2015-01-01

    干燥闭塞性阴茎头炎是发生于男性包皮、阴茎头及尿道的慢性上皮炎症性皮肤病.该病在国内一直被认为属罕见病,很多泌尿科医师对该病的认识不足.近年来随着相关研究的不断开展,关于该病的认识不断被更新,同时也发现,该病在国内的发病率亦呈上升趋势.本文结合国内外相关研究进展,综述关于干燥性阴茎头炎的新情报,如流行病学、临床特征、病因、治疗方案等,为泌尿科同道提供本病的最新信息.

  1. Fibrinogen salvage during DF Thermo using Evaflux-5A plasma fractionators.

    Science.gov (United States)

    Nakashima, Momoko; Yasui, Masahide; Ihara, Akira

    2012-10-01

    DF Thermo, a modified form of double-filtration plasmapheresis (DFPP), has been used for the treatment of various indications such as arteriosclerosis obliterans (ASO). In case of ASO, fibrinogen is a substance to be removed by DFPP. On the other hand, plasmapheresis for chronic viral hepatitis C became an insurance covered treatment in Japan in April 2008. Since then DFPP has also become a treatment of chronic viral hepatitis C as an adjunctive therapy for the purpose of improving the effect of medication. Therefore, there has been a growing concern in recent years about patients' low fibrinogen levels due to DFPP treatment. With the aim of improving fibrinogen retention by DF Thermo, we examined by in vitro trial, the effects when recirculating the filtrate and elevating its temperature. The trial was conducted using bovine plasma, run through experimental circuits with the same configuration as the clinical setting of the One-Way method and DF Thermo method. The DF Thermo circuit contained a thermostat, on which the temperature was set to 40°C. Two One-Way method circuits were prepared with different temperature settings, i.e., 20°C and 40°C. With these three different conditions, variance of the fibrinogen retention under different temperatures and the implementation of recirculation were compared. Results show that the DF Thermo circuit tends to have enhanced the fibrinogen retention compared to the One-Way method 20°C and 40°C. The explanation is likely as follows: viscosity of plasma reduces when warmed, which in turn helps maintain the permeability of membrane, and the recirculation of the plasma helps prevent membrane fouling, thus more fibrinogen is retained in the DF Thermo method.

  2. Spinal Cord Infarction

    Science.gov (United States)

    ... arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major ... infarction is caused by a specific form of arteriosclerosis called atheromatosis, in which a deposit or accumulation ...

  3. Influencia del Polimorfismo Genético en la Apolipoproteína E y C-III sobre la prevalencia de Arteriosclerosis y Demencia en la Enfermedad de Parkinson con y sin Lesiones Vasculares.

    OpenAIRE

    Jiménez Marín, Andrés

    2016-01-01

    La Enfermedad de Parkinson (EP) está causada por un déficit de dopamina en los ganglios basales. Existe una entidad clínica que cursa con los mismos signos y síntomas que la EP cuyo origen es una lesión vascular en los ganglios basales, llamándose a esta entidad Parkinson Vascular (PV). Variso estudios han demostrado que la presencia del alelo E4 de la apolipoproteían E (apo E) comporta un mayor riesgo cardiovascular dado que presenta un peor...

  4. ISCHEMIA-INDUCED TRANSPLANT ARTERIOSCLEROSIS IN RATS AORTIC ISOGRAFT%缺血损伤诱导同品系大鼠腹主动脉移植硬化实验研究

    Institute of Scientific and Technical Information of China (English)

    万云乐; 李波; 沈文律; 罗义刚; 李幼平

    2000-01-01

    目的探索缺血损伤在同品系大鼠腹主动脉移植硬化中的作用.方法将90只大鼠随机分为3组:A组为同品系(Wistar to Wistar)移植缺血小于30分钟组;B组为同品系移植缺血4小时组;C组为异品系(SD to Wistar)移植缺血小于30分钟组.于移植术后15、30及60天切取植入的腹主动脉进行光镜和电镜检查,应用MIAS-300计算机图像分析系统自动测量移植腹主动脉管腔面积、内膜面积和中膜面积.结果 A组术后60天动脉内膜轻度增厚,但B组和C组术后60天均有明显管腔面积缩小和内膜增厚现象,与A组比较差异有显著性意义(P<0.05).病理检查结果表明,B组和C组增生的内膜均由单核/巨噬细胞和平滑肌细胞构成,但前者无中膜层平滑肌坏死及弹力膜断裂现象.结论缺血/再灌注损伤是移植动脉硬化的一个重要因素.

  5. Observation of Curative Effect on Cerebral Arteriosclerosis Treated by Deng zhan Huasu Injection and Cerebrolysin%灯盏花素注射液合脑活素治疗脑动脉硬化症疗效观察

    Institute of Scientific and Technical Information of China (English)

    尹韶刚

    2004-01-01

    目的:观察灯盏花素注射液合脑活素治疗脑动脉硬化症的疗效.方法:将185例随机分为两组:对照组94例采用脑活素静脉注射,每天1次;治疗组91例,在上述治疗的基础上,加用灯盏花素注射液静脉注射,每天1次.观察治疗前后主要临床症状和患者血浆一氧化氮(NO)、内皮素(ET)的变化.结果:治疗组临床总有效率为(88.10%)显著高于对照组(67.47%),(P<0.05);治疗组治疗后血浆NO水平上升,ET值下降,与对照组比较有显著性差异(P<0.05).结论:灯盏花素注射液合脑活素治疗脑动脉硬化症疗效显著.

  6. 不同糖调节受损状态对早期动脉粥样硬化的影响%Association between different impaired glucose regulation and the early-stage arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    赵静; 梁军; 窦连军; 龚莹; 腾飞

    2012-01-01

    目的:探讨糖尿病前期不同血糖水平对颈-股动脉脉搏波传导速度(carotid-to-femoral pulse wave velocity,c-f PWV)的影响.方法:对5 098例非糖尿病者的空腹血糖、口服葡萄糖耐量试验2小时血糖 (2-hour oral glucose tolerance test,2h OGTT)、糖化血红蛋白(hemoglobin A1c,HbA1c)和c-f PWV水平进行分析.结果:空腹血糖受损(impaired fasting glucose,IFG)组、糖耐量受损 (impaired glucose tolerance,IGT)组和高HbA1c组与糖耐量正常组的c-f PWV差异分别为0.97 m/s、1.08 m/s 和 0.92 m/s,差异有统计学意义(P<0.01).高HbA1c合并IFG、高HbA1c合并IGT的c-f PWV明显高于单纯高HbA1c(P=0.036,P=0.03).IFG合并高HbA1c、IGT合并高HbA1c的c-f PWV明显高于单纯IFG 和单纯IGT (P=0.02,P=0.04).结论:c-f PWV水平与糖尿病前期相关联,并独立于其他代谢因素.IFG合并高HbA1c、IGT合并高HbA1c对c-f PWV水平的影响呈叠加效应,提示糖尿病前期不同糖调节受损状态均可引起血管弹性的改变,导致早期动脉粥样硬化发生.%Objective: To explore the associations of glucose exposure and carotid-to-femoral pulse wave velocity ( c-f PWV ) in prediabetes adults. Methods: Fasting plasma glucose, 2-hour oral glucose tolerance test ( 2h OGTT ), hemoglobin Alc( HbAlc ) and c-f PWV were analysed in 5 098 non-diabetes subjects. Results: We found that the differences in c-f PWV between individuals with impaired fasting glucose ( IFG ), impaired glucose tolerance ( IGT ), high HbAlc and those without these abnormalities were 0. 97 m/s, 1. 08 m/s and 0. 92 m/s ( P <0. 01 ). In addition, our data indicated that individuals of both high HbAlc and IFG or IGT had significantly higher levels of c-f PWV compared with those who only had high HbAl c ( P = 0. 036 and 0. 03 , respectively ); or those only had IFG ( P - 0. 02 ); or only had IGT ( P = 0.04 ). Conclusion: c-f PWV was associated with prediabetes, independent of metabolic risk factors. We found that individuals of both high HbAlc and IFG or IGT had additive effects on c-f PWV, and all these alterations may contribute to development and progression of atherosclerosis.

  7. The relationship of vitamin D and arteriosclerosis in elder population:a review of the recent advances%维生素 D 与老年动脉粥样硬化的研究进展

    Institute of Scientific and Technical Information of China (English)

    叶明浩; 寿涓; 邱凌; 曲毅; 祝墡珠

    2015-01-01

    Vitamin D not only plays a major role in the human body calcium and phosphorus metabolism and bone calcification, but also closely relates to non-calcium and phosphorus metabolism diseases. The relationship of vitamin D deficiency and atherosclerosis is an increasing attention in the international medical community. Atherosclerosis in patients with vitamin D deficiency is very common, more and more studies began to place emphasis on whether there is a relationship between vitamin D and vitamin D receptor and atherosclerosis. This review aimed to describe the relationship of vitamin D deficiency and cardiovascular disease and related mechanism of vitamin D to participate in atherosclerosis.%维生素 D 在人体钙磷代谢和骨质钙化中有着重要作用,同时,其对非钙磷代谢的一类其他疾病亦有密切关系。其中,维生素 D 缺乏与动脉粥样硬化关系日益受到国际上的重视。临床资料显示动脉粥样硬化患者普遍存在维生素 D 水平低下,越来越多的研究开始关注维生素 D 和维生素 D 受体与动脉粥样硬化之间的关系。液相色谱串联质谱法(LC-MS/MS)测定血浆25-羟维生素 D浓度不仅比常用的酶免法精确度高,而且可以同时检测维生素 D2和维生素 D3的浓度,为探讨维生素 D 与动脉硬化进展的关系和临床指导维生素 D 补充治疗提供有力依据。此文旨在对探讨维生素 D水平与心血管疾病的关系以及维生素 D 参与动脉粥样硬化机制研究作一综述。

  8. 慢性间歇性缺氧对高脂饮食导致的动脉粥样硬化的影响%The effect of high-adiposed diet on arteriosclerosis mold caused by chronic intermittent hypoxia

    Institute of Scientific and Technical Information of China (English)

    荣耀; 杨宇; 罗荧荃

    2008-01-01

    目的:在慢性间歇缺氧的条件下,用高脂饮食方法建立兔的动脉粥样硬化模型,探讨相关致病机制.方法:24只新西兰兔,随机分为对照组、缺氧组、高脂饮食组、高脂饮食合并缺氧组.每组6只.观察各组兔第0周、第6周、第10周外周血血脂指标和C反应蛋白变化;实验第10周取各组兔主动脉光镜下观察病理学变化.结果:各实验组第6周时的血脂学指标与实验开始时比较均显著升高(P高脂饮食组>缺氧组.结论:单纯慢性缺氧10周可使兔动脉产生动脉粥样硬化的早期病变;慢性间歇缺氧合并高脂饮食10周时可使兔主动脉形成动脉粥样硬化斑块.

  9. Color Doppler Ultrasound of the Carotid Arteriosclerosis with Acute Cerebral Infarction%彩色多普勒超声检测急性脑梗死患者颈动脉硬化病变的价值探讨

    Institute of Scientific and Technical Information of China (English)

    王小燕; 蓝春勇; 钟维章; 张步林

    2009-01-01

    目的 评价彩色多普勒超声(color Doppler ultrasound,CDU)在急性脑梗死患者颈动脉硬化病变中的价值.方法 应用CDU对30例急性脑梗死患者颅外段颈动脉血管检测,每例患者均同时行DSA检查,并将2种检查方法的结果进行一致性检验(Kappa检验).结果 以DSA检查结果为金标准,CDU诊断颈动脉狭窄及闭塞的敏感性、特异性及准确性分别为87.6%、94.85%、 92%.诊断中重度狭窄以上的敏感性、特异性及准确性分别95.6%,95.8%,95.8%.一致性检验结果表明CDU和DSA 2种方法的检查结果的一致性良好(Kappa值=0.742).结论 在评估狭窄程度方面,CDU与DSA一致性好,对于大多数中、重度以上的狭窄,CDU可以取代有创性DSA,甚至仅凭超声检查结果就能对70%~99%狭窄病例的诊断治疗方案进行选择.

  10. 动脉硬化闭塞症(ASO)血管内皮细胞损伤的研究进展%Researching progress on Blood Vessel Endothelium Trauma of Arteriosclerosis Obliteration

    Institute of Scientific and Technical Information of China (English)

    张毅奎; 李令根

    2002-01-01

    @@动脉硬化闭塞症(Atherosclerosis obliterans简称:ASO)多见于40岁以上的中老年人,男性多于女性,比例约为8:1。由于动脉内膜粥样改变,而导致管腔狭窄、闭塞,发生肢体血液循环障碍,甚至出现溃疡或坏疽,是全身性动脉硬化在肢体的局部表现,为常见的慢性肢体动脉闭塞性疾病。本文重点介绍各种损伤血管内皮细胞因素在ASO形成中的作用。 1 血浆脂蛋白(lipoprotein简称:Lp)对血管内皮细胞的损伤 动脉粥样硬化发生机理与血浆脂质代谢失调密……

  11. SAVVY球囊行PTA治疗下肢动脉流出道硬化闭塞症%Treatment of arteriosclerosis obliterations of outflow tract of lower extremity artery by PTA with SAVVY balloon catheter

    Institute of Scientific and Technical Information of China (English)

    蒋天鹏; 周石; 李兴; 宋杰; 向贤宏

    2010-01-01

    目的 观察SAVVY球囊治疗下肢动脉流出道硬化闭塞症的近期疗效.方法 回顺性分析2008年9月~2009年12月间采用SAVVY球囊行下肢动脉流出道血管PTA的15例共22条患肢,其中男12例,女3例,年龄26~88岁.糖尿病下肢动脉硬化闭塞症11例(18支),非糖尿病下肢动脉硬化闭塞症4例(4支),AB10.1~0.3有9条,0.3以上13条.球囊直径选择2~4mm,长度10cm.术后低分子肝素皮下注射7d并长期口服阿司匹林或氯吡格雷.监测术后7d及1个月后ABI变化情况,随访半年后复查超声,或根据症状复发情况及时复查血管造影.结果 手术技术成功率90.9%(20/22).4例伴皮肤溃疡或足趾坏疽的肢体最终单侧截肢,其中1例为感染性病变致血管闭塞病例治疗失败,扩张狭窄段后造影管腔末显示开通,再次扩张仍无效;另1例为非糖尿病动脉硬化闭塞症高龄患者多节段狭窄,扩张后管腔狭窄无变化.术中末出现与球囊结构相关的并发症.术后7dABI在14条血管中升高超过0.5,3条超过0.3,3条超过0.1.随访时间平均7.2个月,有5例复发不同程度静息痛.术后7dABI平均为0.74,1个月平均为0.66.结论 使用SAVVY长球囊行PTA治疗膝下动脉缺血性病变安全、有效,短期疗效肯定.

  12. 糖尿病性下肢血管病变腔内治疗的策略与技术%Strategy and Technique on Endovascular Intervention for Diabetic Lower Extremity Arteriosclerosis Obliteration

    Institute of Scientific and Technical Information of China (English)

    顾洪斌; 王志鸿; 贾荣娟

    2014-01-01

    糖尿病性下肢动脉硬化闭塞症的特点是多水平、长节段,更多累及膝下小动脉.经皮腔内血管成形术作为一种微创治疗方法,更适用于一般状况差、年龄大、合并多种并发症的糖尿病患者,尤其是糖尿病性下肢动脉硬化闭塞性病变导致重症肢体缺血时.在对糖尿病性下肢血管病变施行腔内治疗时,必须努力提高慢性完全闭塞病变的成功率,注意介入治疗入路的选择,严格血管内支架的使用适应证,重视膝下与踝下动脉病变的处理.

  13. Discussion of relationship between arteriosclerosis obliteration and aorta abdominalis calcification%动脉硬化性闭塞症中医分型与腹主动脉钙化关系探讨

    Institute of Scientific and Technical Information of China (English)

    陈云翔; 张洁; 赵峰; 陈林河; 谭中建

    2004-01-01

    目的:探讨动脉硬化性闭塞症中医辨证分型与腹主动脉钙化类型的关系,为动脉硬化性闭塞症中医辨证分型提供客观指标.方法:选取临床已经确诊为动脉硬化性闭塞症,中医辨证分型明确,且腰椎正侧位X线平片检查可见腹主动脉钙化的患者共268例,进行回顾性分析与总结.结果:斑点状或细条状钙化主要见于脉络寒凝证及脉络血瘀证,双轨状钙化主要见于脉络瘀热证,管状钙化主要见于脉络热毒证,且均有统计学意义.结论:动脉硬化性闭塞症中医辨证分型与腹主动脉钙化的类型具有明显相关性,可作为中医辨证分型的客观参考指标之一.

  14. Treatment of arteriosclerosis obliterations on outflow tract of lower extremity artery by PTA with Deep balloon catheters%Deep球囊PTA治疗下肢动脉流出道硬化闭塞症

    Institute of Scientific and Technical Information of China (English)

    张建勇; 蒋米尔; 肖红; 潘金强

    2008-01-01

    目的 探讨Deep球囊经皮腔内血管成形术(PTA)微创治疗下肢动脉流出道硬化闭塞症的疗效.方法 Deep球囊PTA治疗下肢动脉流出道硬化闭塞症26条肢体,观察其即时成功率,多普勒超声随访已治疗处再闭塞率,对治疗前后的踝/肱指数(ABI)、趾端皮肤温度(TTS)以及流出道动脉造影显影分数(OTVC)采用方差分析进行比较.结果 全组经Deep球囊PTA微创治疗的即时成功率为100%.与治疗前比较,治疗后第1个月ABI具有显著差异(P<0.05),第6个月ABI无显著差异(P>0.05),但TTS有显著差异(P<0.05),第6个月下肢动脉流出道已闭塞的12条肢体的OTVC有显著差异(P<0.05).下肢动脉流出道已治疗处1、3和6个月的再闭塞率分别为3.85%、38.46%和46.15%.结论 采用Deep球囊PTA微创治疗下肢动脉流出道硬化闭塞症可促进动脉侧支血管生成,改善血供,提高TTS.

  15. Endovascular revascularization for lower extremity atherosclerosis obliterans in elderly patients: a report of 86 cases%老年人下肢动脉硬化闭塞症腔内治疗效果分析

    Institute of Scientific and Technical Information of China (English)

    叶炜; 管珩; 刘昌伟; 李拥军; 郑月宏; 吴继东; 刘暴; 曾嵘; 吴巍巍; 宋小军

    2010-01-01

    Objective To analyze the outcome and risk factors of endovascular revascularization of lower limb artery for elder patients. Methods From January 2006 to November 2008, 86 elder patients (98 iachemia limbs) underwent endovascular revascularization due to lower limb ischemia. Age of this group were 60 to 82 years old with a mean of (70±6) years old. Fifty-four limbs (55.0%) had severe intermittent claudication, 28 limbs (28.6%) had rest pain, 11 limbs (11.2%) had ulcer, and 5 limbs (5.1%) had gangrene. Sixty-six limbs were mono segment disease, including 25 aorta-iliac lesions, 33 femoral-popliteal lesions and 8 infra-popliteal lesions. Thirty-two limbs were multiple segment disease involving 2 or 3 segment lesions. Mortality, morbidity, primary pateney, secondary pateney and limb salvage were retrospectively analyzed. Risk factors on outcome were also evaluated. Results Ten limbs underwent angioplasty, while the rest 88 limbs underwent angioplasty plus primary stent implantation. The total operation success rate was 95.9%. Perioperative mortality within the first 30 d was 0. Perioperative morbidity within the first 30 d was 5 cases (5.1%), including 2 myocardial infarction, 2 major amputations and 1 irreversible contrast-induced nephropathy. Follow-up duration were 1 to 35 months with a mean of (18±10) months. Eighty-three (96.5%) patients had effectively follow-up. Mortality was 2.3% (2 cases died due to myocardial infarction). Primary patency rate was 83.7%, secondary patency rate was 94.9% and limb salvage rate was 95.9%. Risk factor analysis showed that diabetes mellitas, critical ischemia and multiple segment lesions were associated with worse patency. Conclusions Endovascular treatment is effective, safe and repeatable revascularization for elder patients of Critical lower limb ischemia. Patients with diabetes mellitus, critical ischemia and multiple segment lesions should be paid more attention because their rather worse outcome.%目的 分析老年人下肢动脉硬化闭塞症腔内治疗的临床效果及影响预后的因素.方法 回顾性总结2006年1月至2008年11月收治的86例(98条肢体)下肢动脉硬化闭塞症老年患者的临床资料.本组患者男性56例,女性30例;年龄60~82岁,平均(70±6)岁.临床症状包括重度间歇性跛行54条肢体,静息痛28条肢体,肢体溃疡11条肢体,严重坏疽5条肢体.主髂动脉病变25条肢体,股腘动脉段病变33条肢体,胫腓动脉病变8条肢体,髂股腘动脉多节段病变32条肢体.全部患者接受下肢动脉腔内治疗,总结围手术期要点及影响预后的主要因素.结果 急诊手术8条肢体,择期手术90条肢体.单纯行球囊成形10条肢体,球囊成形+支架植入88条肢体.手术成功率95.9%,围手术期严重并发症5例(5.1%),其中心肌梗死2例,一期大腿截肢2例,不可逆造影剂肾病1例.无围手术期死亡.全组83例患者术后随访1~35个月,平均(18±10)个月,随访率96.5%.随访期内死亡2例,病死率2.3%.血管一期通畅率83.7%,二期通畅率94.9%.踝关节以上截肢4例,保肢率95.9%;另有6例行截趾或截足.因素分析显示,治疗效果与糖尿病史、缺血程度和病变范围相关.结论 下肢动脉腔内重建具有微创、安全以及可重复性等优点,应作为治疗老年下肢缺血首先考虑的治疗方法.糖尿病史、缺血程度和病变范围是影响下肢动脉腔内重建效果的主要因素.

  16. 儿童闭塞性细支气管炎的临床表现与高分辨率CT特点%Clinical manifestations and high resolution CT features of bronchiolitis obliterans

    Institute of Scientific and Technical Information of China (English)

    周俊霖; 丁山; 朱晓华; 郑巍

    2012-01-01

    Objective To study the clinical manifestations and high resolution CT( HRCT) characteristics of bronchiolitis obliter-ans(BO) , so that to improve the understanding of it. Methods Clinical and CT data in 27 patients(22 boys and 5 girls, aged from 2 months to 5 years, and mean age 15. 4 months) with clinical confirmation of BO were retrospectively analysed. All the patients pres-ented with persistent cough and asthma. All cases underwent chest radiograph, HRCT examinations and blood gas analysis. 10 ca-ses and 5 cases underwent bronchoscopy and pulmonary function test, respectively. Results In 27 cases,24 cases were post-infec-tions BO and the others were premature infants after injury of lungs. Hypoxemia in 14 cases and respiratory failure in 4 cases were showed by blood gas analysis. Ten cases who underwent bronchoscopy showed chronic endobronchial infection. HRCT features in-cluded direct signs (peripheral bronchiectasis and bronchial wall thickening in 16 cases, centrilobular nodules in 5 cases) and indirect signs(bronchiectasis and bronchial wall thickening in 20 cases, air trapping signs in 5 cases, mosaic perfusion signs in 25 cases, con-solidation in 10 cases and atelectasis in 5 cases). Conclusion In most of the patients with BO present following infections. HRCT is of important value in the early diagnosis and evaluation of outcome of BO.%目的 探讨闭塞性支气管炎(BO)的临床表现与高分辨率CT(HRCT)特点,提高对本病的认识.方法 回顾性分析27例经临床诊断证实的儿童闭塞性细支气管炎的临床和CT资料,年龄2个月~5岁,平均15.4月,男22例,女5例.反复咳喘病程均在6周以上.27例患儿均行X线胸片,肺部高分辨率CT及血气分析.10例行电子纤维支气管镜检查,5例行肺功能检查.结果 27例确诊为BO患儿,3例为早产儿肺损伤后,余24例为感染后.血气分析示低氧血症14例,呼吸衰竭4例.10例行电子纤维支气管镜检查均提示有支气管内膜慢性感染.肺部高分辨CT检查,直接征象:外周细支气管扩张、管壁增厚(16例);小叶中心性支气管结节影(5例).间接征象:大支气管扩张、管壁增厚(20例);空气潴留征(5例)和马赛克灌注征(25例);肺实变(10例)、肺膨胀不全(5例).结论 儿童BO多为感染后起病,HRCT对该病的早期诊断及预后评价具有重要价值.

  17. Intravenous prostacyclin analogue iloprost (Ilomedin® in the treatment of a patient with Buerger’s disease

    Directory of Open Access Journals (Sweden)

    Ilshat Ravilevich Gaisin

    2013-01-01

    Full Text Available Buerger’s disease, or thromboangiitis obliterans, is a severe disabling systemic disease of vessels. The paper describes a case of thromboangiitis obliterans in a patient with three extremities amputated during vascular therapy. The course intravenous administration of the stable prostacyclin analogue iloprost (Ilomedin® allows the only extremity to be preserved.

  18. RESPIRATORY VIRAL-INFECTIONS AGGRAVATE AIRWAY DAMAGE CAUSED BY CHRONIC REJECTION IN RAT LUNG ALLOGRAFTS

    NARCIS (Netherlands)

    WINTER, JB; GOUW, ASH; GROEN, M; WILDEVUUR, C; PROP, J

    1994-01-01

    Airway damage resulting in bronchiolitis obliterans occurs frequently in patients after heart-lung and lung transplantation. Generally, chronic rejection is assumed to be the most important cause of bronchiolitis obliterans. However, viral infections might also be potential causes of airway damage a

  19. The ASSURE ROT Registry: Bioresorbable Vascular Scaffold Following Rotablation for Complex Coronary Lesions

    Science.gov (United States)

    2015-02-05

    Cardiovascular Diseases; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Coronary Restenosis; Heart Diseases; Coronary Stenosis; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

  20. A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

    Science.gov (United States)

    2016-07-20

    Ischemia; Peripheral Arterial Disease; Peripheral Vascular Disease; Vascular Disease; Arterial Occlusive Disease; Arteriosclerosis; Atherosclerosis; Cardiovascular Disease; Pathologic Processes; Orthopedic Procedures; Amputation

  1. Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery

    Science.gov (United States)

    2016-07-05

    Complications Due to Coronary Artery Bypass Graft; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

  2. Central Obesity and Disease Risk in Japanese Americans

    Science.gov (United States)

    2016-02-08

    Cardiovascular Diseases; Heart Diseases; Atherosclerosis; Hypertension; Obesity; Diabetes Mellitus, Non-insulin Dependent; Hyperinsulinism; Insulin Resistance; Coronary Arteriosclerosis; Diabetes Mellitus; Metabolic Syndrome X

  3. Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice

    Science.gov (United States)

    2014-10-15

    severity of ischemic injury in multiple tissues. Arteriosclerosis , Thrombosis, and Vascular Biology, 31(8), 1748–1756. 25. Meier, P., Gloekler, S...by activating neuropeptide Y and its Y1 receptors. Arteriosclerosis , Thrombosis, and Vascular Biology, 25(10), 2075–2080. 28. Najafi, A. H., Aghili, N

  4. 脐带间充质干细胞移植治疗50例缺血性下肢血管病的临床研究%The Clinical Research of Umbilical Cord Mesenchymal Stem Cells Transplantation in The Treatment of 50 Cases of Lower Limb Vascular Disease

    Institute of Scientific and Technical Information of China (English)

    杜艳; 周毅; 李贞艳; 徐黎鸣; 杜玲

    2013-01-01

    目的:观察脐带间充质干细胞移植治疗缺血性下肢血管病的临床疗效并观察近期临床效果.方法:50例自愿接收脐带间充质干细胞移植患者中糖尿病足35例,动脉硬化闭塞症10例,血栓性闭塞性脉管炎5例.全部患者均给予静脉输注及局部种植脐带间充质干细胞.术后第7天至6个月定期观察各项指标的变化.结果:治疗1月后,47例(94%)疼痛有不同程度的缓解,46例(92%)患肢冷感明显缓解,45例(90%)患者行走距离延长.6月后30例糖尿病足患者溃疡或足部坏疽痊愈.结论:脐带间充质干细胞移植治疗缺血性下肢血管病是一种简便、安全、有效的治疗方法,其治疗的近期疗效显著,使很多患者免除截肢或降低截肢平面,明显改善患者生活质量.%Objective: To investigate the umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic vascular disease the clinical curative effect of the lower limbs watching the recent clinical effect. Methods: Fifty patients with voluntary receiving umbilical cord mesenchymal stem cells transplantation in patients with diabetes foot 35 patients, arteriosclerosis block disease 10 cases, thrombosis obliterans 5 cases. All patients were given intravenous and local planting umbilical cord mesenchymal stem cells. Postoperative seven days to six months each index of change regularly observation. Results: 1 month after treatment, 47 patients (94%) had different degrees of pain relief, 46 cases (92%) limb cold feeling significant relief, 45 patients (90%) patients walking distance to extend. After six months, 30 cases of patients with diabetes foot ulcers or foot gangrene healed. Conclusions: Umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic lower limb vascular disease is a simple, safe and effective in the treatment of method, the treatment of recent curative effect is distinct, making a lot of patients from amputation or reduce

  5. The evaluation of surgical reconstruction for intermittent claudication by the Walking Impairment Questionnaire Avaliação da reconstrução cirúrgica para claudicação intermitente pelo Walking Impairment Questionnaire

    Directory of Open Access Journals (Sweden)

    Masaya Nakashima

    2010-12-01

    Full Text Available BACKGROUND: No standards reflecting the quality of life (QOL and activity of daily living (ADL in postoperative clinical course have been validated in the area of vascular disease. The Walking Impairment Questionnaire (WIQ is a disease-specific questionnaire that evaluates patients with intermittent claudication due to arteriosclerosis obliterans (ASO. The WIQ uses four subscales: pain severity, walking distance, walking speed, and stair climbing while walking. OBJECTIVE: To evaluate the correlation between postoperative arterial blood flow and the Japanese edition of the WIQ. METHODS: Thirty-one patients (47 limbs with intermittent claudication who had been subjected to lower limb surgical arterial reconstruction were assessed by WIQ, and compared with Ankle-Brachial Pressure Index (ABPI and angiography. RESULTS: A significant increase in the WIQ score was identified in walking pain (26 versus 89.5, pINTRODUÇÃO: Nenhum padrão de qualidade de vida e atividades diárias no período pós-operatório já foi validado na área de doenças vasculares. O Walking Impairment Questionnaire (WIQ é um questionário específico para pacientes com claudicação intermitente devido à aterosclerose obliterante. O WIQ se baseia em quatro subescalas: intensidade da dor, distância caminhada, velocidade de caminhada e subir degraus durante caminhada. OBJETIVO: Avaliar a correlação entre fluxo sanguíneo periférico pós-operatório e a edição japonesa do WIQ. MÉTODOS: Trinta e um pacientes (totalizando 47 membros inferiores com claudicação intermitente que se submeteram à reconstrução arterial cirúrgica foram avaliados pelo WIQ e comparados por meio do índice de pressão tornozelo-braço (ITB e angiografia. RESULTADOS: Um aumento significativo no escore do WIQ foi observado em relação à dor durante caminhada (26 versus 89,5, p<0,001, distância caminhada (13,1 versus 83,3, p<0,001, velocidade da caminhada (10 versus 46, p<0,001 e ato de subir

  6. Comparative study of lower extremity CTA and enhanced MRA in patients with arterial occlusive disease of lower extremity%双下肢CTA和增强MRA在双下肢动脉硬化闭塞症中的对比研究

    Institute of Scientific and Technical Information of China (English)

    黄德珍; 徐向阳; 周红梅; 李莹; 张慧娟; 丁蓓; 柳湘洁

    2016-01-01

    Objective:To comparatively study the value and advantage of CT angiography (CTA) and Contrast‐enhanced magnetic resonance angiography (CE‐MRA ) in diagnosing the lower extremity arteriosclerosis obliterans syndrome (LEASO) ,compared with digital subtraction angiography (DSA) as a gold standard .Methods :The images of CTA and CE‐MRA of 40 cases proven LEASO by DSA and clinical symptoms were analyzed ,and the diagnosis accuracy of obliteration sites and stenosis degree checked by CTA and CE‐MRA were analyzed by statistical methods .Results :The stenosis degree of 305 arteries diagnosed by DSA were more than 50% ,including 63 iliac ar‐teries ,128 femoral and popliteal arteries and 114 tibiofibular arteries .The consistent rate of CTA and CE‐MRA in the diagnosis of vascular lesions was 90 .82% and 84 .59% respectively ,and the consistency of CTA and CE‐MRA compared with DSA in diagnosing each segment of artery was higher ,and there was no significant difference(P>0 . 05) .The coincidence rate of assessment of stenosis degree by CTA compared with DSA was 90 .51% ,which was higher than that by CE‐MRA ,and the difference was significant (P<0 .01) .Conclusion: It is valuable o f both CTA and CE‐MRA in diagnosing the LEASO ,and both them has the same value in the location diagnosis .But the assessment accuracy of stenosis degree by CTA is higher ,which can be as a reliable diagnostic method of LEASO .%目的:探讨CT 动脉血管成像(CTA)和增强磁共振血管成像(CE‐MRA)在双下肢动脉硬化闭塞症(LEASO )诊断中的价值和优势。方法:对本院经DSA 和临床确诊为LEASO的40例患者的下肢CTA和CE‐MRA的图像进行分析,并用统计学方法分析两种检查方法对闭塞部位诊断及评估狭窄程度的准确性。结果:经DSA诊断狭窄程度大于50%的共有305段血管,其中髂动脉段有63段,股腘动脉段有128段,经胫腓动脉段有114段;CTA和CE‐MRA对病变血管的定

  7. Effect and impact of alendronate on arteriosclerosis in postmenopausal patients with diabetic osteoporosis%阿仑膦酸钠治疗绝经后糖尿病性骨质疏松的疗效及对动脉硬化的影响

    Institute of Scientific and Technical Information of China (English)

    马丹军; 王征; 任洪丽; 孙秀娟; 周菁荣

    2015-01-01

    Objective To investigate the effect of alendronate sodium in treatment of postmenopausal diabetic osteo-porosis( DOP) and effect on atherosclerosis( AS) .Methods 86 cases of postmenopausal DOP patients were randomly divided into treatment group and control group with 43 cases in each group.All patients were given Caltrate D oral based on quantified diet, exercise therapy and blood sugar control, the treatment group was treated with Allen alendronate 70 mg/week for 6 months.Bone mineral density (BMD), bone turnover markers and area of plaque and intima-media thickness (IMT) changes between the 2 groups were observed.Results After treatment, BMD and bone turnover markers were significantly improved in the treatment group ( P 0.05).After the treatment, the treatment group’ s carotid plaque area reduced obviously, IMT was obviously thinning ( t =2.64, 4.61, P 0.05).Plaque area were negative correlated with lumbar L2~4 BMD ( r =-0.578, P <0.05), IMT was negatively correlated with Wards triangle and Troch BMD (r =-0.591, -0.541, P <0.05).Conclusion Postmenopausal patients with type 2 diabetes are at high risk of postmenopausal diabetic osteoprosis, Allen phosphonic acid sodium in treatment of postmenopausal DOP is safe and effective, can significantly increase the bone density, decrease bone conversion level, and has a certain role in the prevention and treatment of atheroscle-rosis.%目的:探讨阿仑膦酸钠治疗绝经后糖尿病性骨质疏松(DOP)患者的疗效及其对动脉硬化(AS)的影响。方法将绝经后DOP患者86例随机分为治疗组和对照组各43例。所有患者均在量化饮食、运动治疗及控制血糖的基础上给予钙尔奇D口服,治疗组加用阿仑膦酸钠70 mg/周,连服6个月。观察2组患者骨密度( BMD)、骨转换指标及斑块面积和内膜中层厚度( IMT)的变化。结果治疗后治疗组各部位BMD及骨转换指标均较治疗前显著改善( P <0.05),且L2~4、股骨颈、Wards三角的BMD及甲状旁腺素(PTH)、I型胶原羧基端肽β特殊序列(β-CTX)改善均显著优于对照组( t =3.91、2.62、3.70、2.68、3.17, P <0.05);而对照组各指标均无明显改善( P >0.05)。治疗后,治疗组颈动脉斑块面积明显减小、IMT明显变薄( t =2.64、4.61, P <0.05),且治疗组均优于对照组( t =3.01、2.79, P <0.05);而对照组无显著改善( P >0.05)。斑块面积与腰椎L2~4的BMD呈负相关( r =-0.578, P <0.05),IMT与Wards三角、Troch的BMD呈负相关( r =-0.591、-0.541, P <0.05)。结论绝经后2型糖尿病患者是糖尿病性骨质疏松的高危人群,阿仑膦酸钠治疗绝经后DOP安全有效,可明显增加骨密度,降低骨转化水平,且对AS具有一定防治作用。

  8. Impact of different lipid lowering scheme on the liver and kidney function and endothelial function in arteriosclerosis rats model%不同调脂方案对动脉硬化大鼠肝肾功能及血管内皮功能的影响

    Institute of Scientific and Technical Information of China (English)

    徐艳玲; 张静; 周琳

    2013-01-01

    Objective To investigate vascular endothelial function,liver function and renal function of mixed hyperlipidemia rats treated by different ways including high doses of simvastatin and small doses of simvastatin combined with ezetimibe.Methods Forty-two healthy Wistar 6-month-old male rats were randomly divided into five groups,including normal control group (n =8),hyperlipidemia control group (n =10),low dose of simvastatin [10 mg/(kg · d)] group (n =8),high dose of simvastatin [20 mg/(kg · d)] group (n =8),simvastatin [10 mg/(kg · d)] combined with ezetimibe [5 mg/(kg · d)] group (n =8).Levels of total cholesterol (TC),lowdensity lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides (TG),alanine aminotransferase (ALT),aspartate aminotransferase (AST),serum creatinine (Scr),urea nitrogen (BUN),uric acid,urine protein,urine creatinine (Ucr),serum creatinine clearance rate (Ccr),C-reactive protein (CRP),soluble thrombomodulin regulatory proteins (sTM) and soluble intercellular adhesion molecule-1 (sICAM-1) and urinary protein were tested in all groups.Renal index was also calculated.Results ① Compared with hyperlipidemia control group,levels of TC,IDL-C,TG,ALT,AST,BUN,uric acid,urine protein,CRP,sTM and sICAM-1 in all the therapeutic groups were significantly lower (P <0.01).But HDL-C and Ccr levels were significantly higher.Renal function were improved and levels of sTM and slCAM-1 were significantly lower (P < 0.01) in high dose of simvastatin [20 mg/(kg· d)] group.Liver function were improved and limpid-lowering were better in simvastatin [10 mg/(kg · d)] combined with ezetimibe [5 mg/(kg · d)] group.②Small size of glomerular and mesangial cell proliferation relief were seen in the therapeutic groups with light microscope.And high dose of simvastatin group had better results.Conclusions ①Compared with simvastatin combined with ezetimibe group,high dose of simvastatin treatment has lower levels of BUN,uric acid,urine protein,sTM and sICAM-1,can reduce renal index,increase Ccr and HDL-C levels,improve glomerular morphology and improve renal function and vascular endothelial function.②Compared with high-dose simvastatin group,small doses of simvastatin and ezetimibe treatment can significantly reduce TC,LDL-C and CRP levels,don't affect serum transaminase levels,and reduce lipid effectively but not increase damage of liver function.%目的 探讨单用较大剂量辛伐他汀与小剂量辛伐他汀联合依折麦布对动脉硬化大鼠血管内皮功能及肝肾功能的影响.方法 将42只健康6月龄Wistar雄性大鼠完全随机分为正常对照组(n=8)、高脂对照组((n=10)、辛伐他汀低剂量组[10 mg/(kg·d),n=8]、辛伐他汀高剂量组[20 mg/(kg·d),n=8)]和辛伐他汀[10 mg/(kg·d)]联合依折麦布[5 mg/(kg·d)]组(n=8),给予相应剂量的辛伐他汀及依折麦布灌胃.分别于实验第8周末眼静脉丛采血及第12周末心脏采血后测定各组大鼠TC、LDL-C、HDL-C、TG、ALT、AST、血清肌酐(Scr)、BUN、尿酸、尿蛋白、尿肌酐(Ucr)、血清肌酐清除率(Ccr)、C反应蛋白(CRP)、可溶性血栓调节蛋白(sTM)和可溶性细胞间黏附因子1(sICAM-1)水平及尿蛋白浓度,并计算肾指数.结果 ①辛伐他汀低剂量组、高剂量组,辛伐他汀联合依折麦布组较高脂对照组TC、LDL-C、TG、ALT、AST、BUN、尿酸、尿蛋白、CRP、sTM、sICAM-1水平明显降低(P<0.01),HDL-C及Ccr水平升高,其中辛伐他汀高剂量组肾功能明显改善[实验12周末血Scr:(2.00±0.47) ml/min比(0.55±0.12) ml/min,BUN:(5.25±0.50) mmol/L比(7.82±0.25) mmol/L,尿酸:(81±17) μmol/L比(142±13) μmol/L,尿蛋白:(1.98±0.18) g/L比(2.89±0.32) g/L]、sTM、sICAM-1水平明显降低[实验12周末sTM:(165±26) g/L比(279±30) g/L,sICAM-1:(20.1±3.2)g/L比(48.1±6.4)g/L],辛伐他汀联合依折麦布组血脂及肝功能明显改善.②光镜下:各处理组肾小球体积小,系膜细胞增生减轻,且均以辛伐他汀高剂量组改善明显.结论 ①单用较大剂量辛伐他汀与小剂量辛伐他汀联合依折麦布相比,能更好降低BUN、尿酸、尿蛋白、sTM和sICAM-1水平,降低肾指数,提高Ccr和HDL-C水平,改善肾小球形态,从而起到改善肾功能及血管内皮功能的作用.②小剂量辛伐他汀联合依折麦布较单用大剂量辛伐他汀更能显著降低TC、LDL-C和CRP水平,且不增加血清转氨酶水平,有效降脂的同时不增加肝功能损害.

  9. Influencia de la dieta y la terapia con atorvastatina sobre la progresión-regresión de la arteriosclerosis en troncos supra-aórticos y correlación con lesiones hepáticas en un modelo experimental en pollos.

    OpenAIRE

    Sánchez Polo, Mª Teresa

    2013-01-01

    This study evaluates the impact of high plasma cholesterol and triglyceride levels on supra-aortic trunk structure, the effects of diet ± atorvastatin on progression-regression of atherosclerosis and its correlation with non-alcoholic fatty liver disease (NAFLD). One-hundred chickens were divided into five groups: A: Standard diet (SD) for 6 months; B: Hyperlipidemic diet (HD) for 6 months; C: HD for three months and SD during the next 3 months; D: HD for 3 months and SD and oral atorvastatin...

  10. 益气通脉方合外洗方治疗早期糖尿病下肢动脉硬化闭塞症的临床观察%Clinical Observation on Treatment of Arteriosclerotic Obliteration of Lower Extremity Arteriosclerosis in Early Diabetes by the Formulas of Promoting Blood Circulation and Replenishing Qi as well as External Douche

    Institute of Scientific and Technical Information of China (English)

    何晓兰

    2005-01-01

    目的观察自拟益气通脉方合外洗方治疗早期糖尿病下肢动脉硬化闭塞症的临床疗效.方法将72例本病早期患者随机分为两组.治疗组40例采用自拟益气通脉方口服及外洗方外洗患肢,对照组32例采用抗凝、调脂等西药治疗,两组均以14天为1个疗程,连续治疗3个疗程.结果治疗组总有效率90%,对照组总有效率59.3%,经统计学处理P<0.01,两组临床症状改善有显著性差异.结论中药益气通脉方口服合外洗方外洗治疗早期糖尿病下肢动脉硬化闭塞症,有较好的疗效,可明显改善临床症状.

  11. 六虫胶囊治疗动脉硬化性闭塞症脉络血瘀证临床疗效观察%Clinical effect of Liuchong Capsules in treating stagnation of blood syndrome in patients with arteriosclerosis obliteration

    Institute of Scientific and Technical Information of China (English)

    石杏柳; 杨建坤; 王立敏

    2009-01-01

    [目的]观察六虫胶囊治疗肢体动脉硬化性闭塞症临床疗效及作用机制.[方法]60例肢体动脉硬化性闭塞症患者随机分为两组治疗,治疗观察周期为30d.[结果]治疗组总有效率为86.7%,对照组为72.3%,有显著性差异(P<0.05).[结论]六虫胶囊治疗肢体动脉硬化性闭塞症具有较好的疗效,其作用机制可能为通过降低血黏度.促进微小血管网形成而增加远端血流量,从而改善缺血症状.

  12. Ultrasound ablation combined with balloon angioplasty for treatment of diabetic patients with arteriosclerosis obliteration of lower extremity and diabetic foot%超声血栓消融及小球囊介入方法治疗糖尿病下肢动脉闭塞硬化症及足坏疽

    Institute of Scientific and Technical Information of China (English)

    吴石白; 袁群; 史国珍; 童奥; 赵娜; 肖黎; 张妲; 王良宸; 唐红

    2008-01-01

    目的:观察血管内超声血栓消融术配合小球囊、支架等介入治疗方法配合内科综合治疗糖尿病合并下肢动脉闭塞硬化症及糖尿病足的临床疗效.方法:对47例糖尿病合并下肢动脉闭塞硬化症患者共60条肢体在内科综合治疗如抗感染、扩血管、改善循环、抗凝的前提下行超声血栓消融术与小球囊、支架等介入治疗.结果:47例60条患肢术中下肢动脉通畅率达93.3%;术后1个月以及术后3个月测定的下肢动脉MRI、超声、踝/肱指数(ABI)、下肢皮肤温度以及肢体凉、麻、痛,皮肤苍白或发绀的缺血状况较术前有不同程度改善,足伤口愈合时间缩短.结论:糖尿病下肢动脉闭塞硬化症合并足坏疽的患者,在传统内科综合治疗基础上,将先进的超声血栓消融技术与小球囊、支架等介入治疗的手段相结合,可以使闭塞的大血管再通,明显改善血供,为糖尿病足坏疽的治愈提供良好的血液循环条件.

  13. Comparative study on the treatment effects of three arteriovenous reversal approaches for arteriosclerosis obliteration of lower limbs%3种动静脉转流术治疗下肢动脉硬化闭塞症的疗效比较

    Institute of Scientific and Technical Information of China (English)

    李浩; 吕伟明; 刘奕山; 林勇杰; 陈国锐

    2001-01-01

    目的 : 探讨不同动静脉转流术术式治疗下肢动脉硬化闭塞症 (ASO) 的疗效.方法 : 17例 ASO患者随机分为 3组,分别施行分期动静脉转流术 (分期转流组,6例 )、一期动静脉转流术 (一期转流组,6例 ) 及一期动静脉转流并水压破坏深静脉瓣膜术 (一期并水压组,5例 ),比较各组术后 14日和术后 6个月动脉血在深静脉中的逆行距离.结果 : 术后 14日和 6个月分期转流组动脉血在深静脉中的逆行距离为 (7.5± 1.4) cm和 (10.8± 1.0) cm; 一期转流组为 (10.5± 1.3) cm和 (19.6± 5.2) cm; 一期转流并水压组为 (28.4± 1.1) cm和 (37.4± 1.7) cm. 结果显示一期并水压组术后 14日及 6个月动脉血在深静脉中的逆行距离均比另两组长.结论 : 一期动静脉转流并水压破坏深静脉瓣膜术能使动脉血在术后短时间内更迅速地向患肢末端灌注,是一种治疗下肢动脉广泛性闭塞的较有效的手术方法.

  14. Constrasting Study of Vascular Tension Factors between Diabetic Arterial Occlusion and Arteriosclerosis Obliterance%糖尿病肢体动脉闭塞症与闭塞性动脉硬化症血管张力因素改变的对比

    Institute of Scientific and Technical Information of China (English)

    陈柏楠; 秦红松; 刘政; 任晋蒙; 许永楷

    2008-01-01

    目的:研究糖尿病肢体动脉闭塞症与闭塞性动脉硬化症,血管收缩因素内皮素-1(ET-1)、血栓素A2(TXA2)和血管舒张因素一氧化氮(NO)、前列环素(PGI2)的各自变化特点.方法:将40例糖尿病肢体动脉闭塞症设为Ⅰ组,50例闭塞性动脉硬化症设为Ⅱ组,30例正常对照设为Ⅲ组.应用放射免疫方法测定血浆ET-1、NO、血栓素B2(TXB2)和6-酮-前列腺素F1α(6-keto-PGF1α)浓度.结果:(1)病变各组的ET-1水平均高于对照组(P0.05).(3)病变各组TXB2水平均高于对照组(P0.05).结论:糖尿病肢体动脉闭塞症与闭塞性动脉硬化症均存在血管张力因素的变化,血管收缩因素明显增强,血管舒张因素明显降低.糖尿病肢体动脉闭塞症患者血管收缩因素和血栓形成因素明显高于闭塞性动脉硬化症患者,而血管舒张因素的受损程度二者无明显差异.

  15. Analysis on curative effects of percutaneous transluminal angioplasty in treatment of patients with arteriosclerosis obliteration of lower extremity%经皮血管腔内血管成形术治疗下肢动脉硬化闭塞症患者的疗效及安全性评价

    Institute of Scientific and Technical Information of China (English)

    何凡; 蔡进中; 王露平; 窦永充; 陈旭东

    2012-01-01

    目的:评价经皮血管腔内血管成形术(PTA)治疗下肢动脉硬化闭塞症患者的临床疗效及安全性,为提高下肢动脉硬化闭塞症的手术成功率提供临床依据.方法:下肢动脉硬化闭塞症患者30例,其中Fontain分期Ⅱ期患者11例,Ⅲ期患者7例,Ⅳ期患者12例,观察所有患者术中血管再通及治疗前后临床症状改善情况.结果:30例患者45支血管行PTA,成功开通42支血管,手术成功率为93.3%.开通血管中行超声斑块消融术血管10支,超声斑块消融+球囊成形术血管20支,超声斑块消融+球囊成形术+支架植入术血管12支.27例患者治疗后临床症状改善,其中FontainⅡ期患者11例(11/11),Ⅲ期患者7例(7/7),Ⅳ期患者9例(9/12).FontainⅡ、Ⅲ期患者术后临床有效率比较差异无统计学意义(P>0.05),Ⅱ、Ⅲ期患者术后临床有效率高于Ⅳ期患者(P<0.05).30例患者中仅1例发生严重并发症,无死亡患者.结论:多种血管腔内血管成形术联合应用可以提高下肢动脉硬化闭塞症的手术成功率;PTA治疗下肢动脉硬化闭塞症安全有效.

  16. Tissue Characterization on Common Carotid Artery using AR Model

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    This study uses one image with a echocardiography and detects arteriosclerosis on the common carotid artery by tissue characterization. The conventional methods are measurement of thickness on the vessel wall or stiffness on the common carotid artery. However, they need frames of several beats and great calculation times. But, we detect the arteriosclerosis with only one image. Our method estimate the grade of arteriosclerosis by AR model parameters fitted to the texture on the lumen-intima wall. Experimental results show the validity of the proposed method.

  17. Application of Bolus-chase Magnetic Resonance Angiography Complicated with Stem Cells Therapy on Diabetic Foot%BOLUS步进减影技术结合干细胞治疗糖尿病足

    Institute of Scientific and Technical Information of China (English)

    田荣华; 刘志刚; 肖刚; 章娟; 马芬

    2012-01-01

    Objective To discuss the clinical application of bolus chase technology in arteriosclerosis obliterans of the lower extremities treatment with stem cells therapy in patients with diabetic foot. Methods The arteria femoralis of uninjured side( unilateral) or slightly injured side( hibateral) of twelve patients were percutaneous punctured with Seldinger,and the tubes were sent to arteria iliaca communis or unilateral target vessel under X-ray;Both lower extremities were took as the start position of bolus chase and dorsum pedis as the end position of bolus chase to do bolus chase technology, showing double or single Artery of lower extremity screenage of entire journey; The percutaneous transluminal balloon angioplasty was used for the stenosis above the knee; The popliteal artery plugging with balloon and stem cells transplantation in distal end for the stenosis below knee. Results Ten cases of low extremity atherosclerosis disease were observed successfully with bolus chase technology ,2 cases failed in which one case was with dexter arteria iliaca communis completely obliteration, the other was with arteria cruralis obliteration. 3 cases were angusty and treated with balloon dilatation, 10 cases were treated with stem cells transplantation after popliteal artery blockade, 1 case underwent balloon dilatation after taking the embolus out the vessel occlusion and stem cells transplantation without blocking the popliteal artery, 1 case received the stem cells injection into aorta abdominalis lower end. 11 in the 12 cases had a better effect. The pain and insensible feeling of patients were relieved obviously. The skin temperature and ABI index number were much higher than that before operation,and the difference was statistical significance( P < 0. 01). The lower limbs anabrosis had been improved in different degrees. Conclusion The bolus chase technology is the most advanced technology in observing anatomy of artery of lower extremity blood vessel and the change of

  18. Breast arterial calcifications : A systematic review and meta-analysis of their determinants and their association with cardiovascular events

    NARCIS (Netherlands)

    Hendriks, Eva J E; de Jong, Pim; van der Graaf, Yolanda; Mali, Willem P Th M; van der Schouw, Yvonne T.; Beulens, Joline W J

    2015-01-01

    Objective: Breast arterial calcifications (BAC), regularly observed at mammography, are medial calcifications and as such an expression of arteriosclerosis. Our objective was to evaluate and summarize the available evidence on the associations of BAC with cardiovascular risk factors and cardiovascul

  19. On Two Hearts and Other Coronary Reflections.

    Science.gov (United States)

    Flannery, Maura C.

    1998-01-01

    Speculates as to how understanding of heart disease has developed and provides insight into how medical science makes progress. Summarizes the state of knowledge on arteriosclerosis, heart attacks, and exercising the heart. Contains 23 references. (DDR)

  20. How wounds heal

    Science.gov (United States)

    ... chronic wounds. Poor blood flow due to clogged arteries ( arteriosclerosis ) or conditions such as varicose veins. Obesity increases the risk of infection after surgery. Being overweight can also put tension on stitches, which can make them break open. ...

  1. Cystatin-C as a predictor for major adverse cardiac events in patients with acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Osama Tayeh

    2012-09-01

    Conclusions: CYS-C could be a useful marker for diagnosing coronary arteriosclerosis. An elevated CYS-C in patients with ACS is an independent predictor of MACE either in-hospital or during follow-up.

  2. Betaine-homocysteine methyltransferase (BHMT) : genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans

    NARCIS (Netherlands)

    Heil, S.G.; Lievers, K.J.A.; Boers, G.H.; Verhoef, P.; Heijer, den M.; Trijbels, F.J.M.; Blom, H.J.

    2000-01-01

    Elevated homocysteine levels have been associated with arteriosclerosis and thrombosis. Hyperhomocysteinemia is caused by altered functioning of enzymes of its metabolism due to either inherited or acquired factors. Betaine-homocysteine methyltransferase (BHMT) serves, next to methionine synthase, a

  3. Ankyloserende spondylitis er associeret med øget kardiovaskulær morbiditet og mortalitet

    DEFF Research Database (Denmark)

    Madsen, Ole Rintek; Lindhardsen, Jesper

    2011-01-01

    Ankylosing spondylitis is an inflammatory disorder primarily affecting the axial skeleton. The disease is associated with increased cardiovascular morbidity and mortality. Structural changes in the heart, and arteriosclerosis secondary to inflammation may be of importance. The role of traditional...

  4. Investigation of Hematologic and Pathologic Response to Decompression.

    Science.gov (United States)

    1978-05-10

    133, 1 958. 314. Stemerman , M.D . and Ross , R. Experimental arteriosclerosis : I . Fibrin plaque formatio n in primates , an electron microscop ic...exhibits marked subperiostea]. new bone i formation . The epiphyseal plate contains areas of necrosis and obliteration . 1 Section of proximal femur...1961 23. Harker , L. A., Ross , R ., Slichter , S. J., ScOtt , R. C. Homocystine induced arteriosclerosis . Am . Soc . d in. Inves., Atlantic City

  5. Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

    Science.gov (United States)

    Ramírez-Romero, Rafael; Nevárez-Garza, Alicia M.; Rodríguez-Tovar, Luis E.; Wong-González, Alfredo; Ledezma-Torres, Rogelio A.; Hernández-Vidal, Gustavo

    2012-01-01

    Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model. PMID:22629176

  6. Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

    Directory of Open Access Journals (Sweden)

    Rafael Ramírez-Romero

    2012-01-01

    Full Text Available Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP and chronic obstructive pulmonary disease (COPD in human beings, calves are proposed as an alternative animal model.

  7. Potential of advanced photoplethysmography sensing for noninvasive vascular diagnostics and early screening

    Science.gov (United States)

    Spigulis, Janis; Kukulis, Indulis; Fridenberga, Eva; Venckus, Girts

    2002-06-01

    Advanced sensor device for shape analysis of the tissue- reflected mean single period photoplethysmography (SPPPG) signals has been designed and clinically tested. The SPPPG signal shape reveals individual features of the patient's cardio-vascular state. Clinical studies of several patient groups (e.g. diabetes mellitus, atherosclerosis obliterans, Raynaud's syndrome) made possible to specify components of the SPPPG signal that are sensitive to the corresponding organic or functional pathologies. Comparison of the right and left arm finger SPPPG signal shapes, for instance, appears to be efficient tool for early screening of unilateral atherosclerosis obliterans.

  8. HRCT findings of chest complications in patients with leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Nobuyuki; Matsumoto, Tsuneo; Miura, Gouji; Emoto, Takuya; Matsunaga, Naofumi [Department of Radiology, Yamaguchi University School of Medicine (Japan)

    2002-06-01

    High-resolution CT (HRCT) findings of several chest complications occurring in leukemic patients were reviewed. Although most entities show non-specific HRCT findings including ground-glass opacity and air-space consolidation, characteristic findings are observed in several pulmonary complications including Pneumocystis carinii pneumonia, fungal infections, miliary tuberculosis, leukemic infiltration, pulmonary edema, bronchiolitis obliterans, and bronchiolitis obliterans organizing pneumonia. A combination of these characteristic HRCT findings and the information obtained from the clinical setting may help in achieving a correct diagnosis of chest complications occurring in leukemic patients. (orig.)

  9. Rheumatoid arthritis and cryptogenic organising pneumonitis.

    Science.gov (United States)

    Rees, J H; Woodhead, M A; Sheppard, M N; du Bois, R M

    1991-05-01

    We describe three patients with rheumatoid arthritis who presented with non-specific pulmonary symptoms, a restrictive defect in lung function and bilateral changes on chest radiograph. Lung histology showed characteristic features of cryptogenic organising pneumonitis and treatment with steroids produced significant improvement. The clinical and laboratory features of cryptogenic organising pneumonitis (otherwise known as bronchiolitis obliterans organising pneumonia, 'BOOP') are discussed and compared with those of bronchiolitis obliterans with which the condition should not be confused. Cryptogenic organising pneumonitis should be considered as one of the pulmonary manifestations of rheumatoid arthritis, but lung biopsy is essential to make the diagnosis.

  10. A N UNUSUAL CASE OF SWYER - JAMES - MACLE O DS SYNDROME WITH DEXTROCARDIA

    Directory of Open Access Journals (Sweden)

    Sahana

    2015-05-01

    Full Text Available Swyer - James/MacLeod S yndrome ( SJMS is an uncommon disease with the haracteristic radiological feature of "unilateral hyperlucency" due to loss of pulmonary vasculature and air trapping . SJMS is considered to be a form of bronchiolitis obliterans that fol lows viral bronchiolitis and pneumonitis . This report describes a rare case of Swyer - James syndrome with dextrocardia diagnosed in a 3 year s old child during evaluation for recurrent respiratory infections . KEYWORDS : Swyer - James/MacLeod syndrome ; Unilateral Hyperlucency ; Bronchiolitis obliterans ; Chest X - ray ; Dextrocardia .

  11. Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus with unusual manifestations and without detectable autoantibodies

    Directory of Open Access Journals (Sweden)

    Jimena Sanz-Bueno

    2014-01-01

    Full Text Available We describe a patient with paraneoplastic autoimmune multiorgan syndrome (PAMS secondary to a lymphoblastic T- cell lymphoma who presented with a lichenoid dermatitis and vitiligo, later developing bronchiolitis obliterans and autoimmune hepatitis. Notably, he had no detectable autoantibodies. The development of vitiligo and autoimmune hepatic involvement probably indicate a role for cytotoxic T- cell lymphocytes in the pathogenesis of this syndrome.

  12. Banff study of pathologic changes in lung allograft biopsy specimens with donor-specific antibodies

    DEFF Research Database (Denmark)

    Wallace, William Dean; Li, Ning; Andersen, Claus B;

    2016-01-01

    -DSAs, and no antibodies (NABs) present. The significance of each histologic variable was reviewed. RESULTS: We found no statistically significant association with acute cellular rejection, airway inflammation, or bronchiolitis obliterans and the presence or absence of antibodies. However, biopsy specimens with DSAs had...

  13. 闭塞性毛细支气管炎1例

    Institute of Scientific and Technical Information of China (English)

    朴香淑

    2009-01-01

    @@ 1901年德国病理学家Lange首次报道并命名了闭塞性毛细支气管炎(bronchiolitis obliterans,BO)[1].吉林省通化市人民医院收治了1例闭塞性毛细支气管炎.现报道如下:

  14. Dyspnea during Advanced Cancer

    Science.gov (United States)

    ... by chemotherapy. Conditions that are not related to cancer: Chronic obstructive pulmonary disease (COPD), such as chronic bronchitis or emphysema . ... depends on the type and stage of the cancer being treated. Laser therapy for tumors inside large ... Postradiation bronchiolitis obliterans Steroid ...

  15. Chronic lung allograft dysfunction after lung transplantation: novel insights into immunological mechanisms

    NARCIS (Netherlands)

    Budding, K.

    2016-01-01

    Lung transplantation (LTx) is the final treatment option for patients suffering from end-stage lung diseases. Survival after LTx is hampered by the development of chronic lung allograft dysfunction which presents itself in an obstructive form as the bronchiolitis obliterans syndrome (BOS). BOS is ha

  16. Is preputioplasty effective and acceptable?

    OpenAIRE

    2003-01-01

    Foreskin complaints in childhood, if not manageable conservatively, are usually treated by circumcision. A less radical surgical option, when balanitis xerotica obliterans is absent, is preputioplasty. We sent questionnaires to the parents of 23 boys who had had this procedure and 22 replied.

  17. Perineal urethrostomy stenosis repair with buccal mucosa: description of technique and report of four cases.

    Science.gov (United States)

    Kamat, Nagesh

    2008-11-01

    Perineal urethrostomy stenosis can be a difficult problem to treat, especially in patients with balanitis xerotica obliterans. We have devised a technique of using the buccal mucosa, with the idea of forming a composite stoma comprising skin and buccal mucosa. We describe the technique and short-term results in 4 patients.

  18. Tortuous Common Carotid Artery: A Report of Four Cases Observed in Cadaveric Dissections

    Directory of Open Access Journals (Sweden)

    Joe Iwanaga

    2016-01-01

    Full Text Available A tortuous common carotid artery poses a high risk of injury during tracheotomy. Preoperative diagnosis is therefore important to avoid serious complications. We found four cases of tortuous common carotid artery during an anatomical dissection course for students. The first case was a 91-year-old woman who had bilateral tortuous common carotid arteries without arteriosclerosis. Case 2 was a 78-year-old woman who had bilateral tortuous common carotid arteries without arteriosclerosis. Case 3 was an 86-year-old woman who died from bladder cancer and who also had a right tortuous common carotid artery without arteriosclerosis. Case 4 was an 89-year-old woman who had bilateral tortuous common carotid arteries and a tortuous brachiocephalic artery with severe arteriosclerosis. Case 4 was also examined using computed tomography to evaluate the arteriosclerosis. Computed tomography revealed severe calcification of the vascular wall, which was confirmed in the aortic arch and origins of its branches. In all four cases, the tortuosity was located below the level of the thyroid gland. Based on prior study results indicating that fusion between the carotid sheath and visceral fascia was often evident at the level of the thyroid gland, we speculated that the major region in which tortuosity occurs is at the same level or inferior to the level of the thyroid gland.

  19. [Spuriously unhealthy animal fats].

    Science.gov (United States)

    Cichosz, Grazyna; Czeczot, Hanna

    2011-11-01

    Animal fats are generally considered as a source of saturated fatty acids and cholesterol, identified with arteriosclerosis and its clinical complications (cardiovascular diseases with heart attack, stroke, cerebral claudication). The real reason of arteriosclerosis are inflammation states of blood vessel endothelium caused by oxidative stress, hiperhomocysteinemia, hipertrigliceridemia, presence of artificial trans isomers and excess of eicosanoids originated from poliunsaturated fatty acids n-6. Present status of science proves that both saturated fatty acids and cholesterol present in animal food can not cause inflammation state. Moreover, animal fats are source of antioxidants active both in food and in human organism. Due to high oxidative stability animal fats do not make threat to human health. Milk fat, though high content of saturated fatty acids and cholesterol, possesses comprehensive pro-health activity--against arteriosclerosis and cancerogenesis.

  20. Surgical treatment of popliteal artery aneurysms:17 cases experience%17例腘动脉瘤的手术治疗经验

    Institute of Scientific and Technical Information of China (English)

    崔凤奎; 鹿凯; 魏福庆; 黄风雷; 刘巍立

    2016-01-01

    ObjectiveTo summarize the experience and effect of the surgical treatment in treating of popliteal artery aneurysm (PAA).MethodsThe clinical data of 17 patients with PAA from January 1999 to December 2011 was analyzed retrospectively. Results17 cases were brought into the research, with 21 limbs involved. The mean age was (45.13±11.24) years. 14 cases were male and 3 cases were female, 4 cases with bilateral lesions. The clinical manifestations were pulsatile mass (15 cases, 71.4%), popliteal fossa pain (5 cases, 23.8%), intermittent claudication (5 cases, 23.8%), acute lower limb ischemia (3 cases, 14.3%). All of the patients had underwent successful surgical treatment. The surgical procedures including aneurysm excision and auto genous great saphenous vein graft in situ(10 cases), aneurysm excision and artificial vascular graft in situ (3 cases), aneurysmligation and artificial vascular bypass graft (4 cases). 3 cases with acute lower limb ischemia underwent embolectomy. 1 case developed thrombosis in artiifcial vascular 6 hours after the operation. The mean follow-up was (7.36±3.58) years. The symptoms had been alleviated in 13 cases. 2 cases with artificial vascular grafts were found anastomotic stenosis 1 year after surgery. 1 patient with arteriosclerosis obliterans had underwent amputation from the lower third of the thigh 8 months after surgery. 1 case was lost to follow-up. The primary patency rate was 81%, limb salvage rate was 95%.Conclusions Surgical treatment is recommended regardless of the size of the PAA. Autogenous saphenous vein is recommended as the preferred graft. Adequate, reasonable anticoagulant or antiplatelet drugs should be administrated after the surgery.%目的:总结腘动脉瘤的手术治疗经验及效果。方法回顾性分析1999年1月至2011年12月收治的腘动脉瘤患者的病历资料。结果共纳入17例患者、21条肢体,其中男性14例、女性3例,平均年龄(45.13±11.24)岁,其中4例患者为

  1. Raynaud's phenomenon in arterial obstructive disease of the hand demonstrated by locally provoked cooling

    DEFF Research Database (Denmark)

    Nielsen, Steen Levin; Nobin, B A; Hirai, M;

    1978-01-01

    Finger systolic blood pressure (FSP) was measured by cuff technique before and after local cooling in three groups of patients (Raynaud's disease (7), subclavian stenoses, (5), thrombo-angiitis obliterans (15)), and in 15 normals. The response to finger cooling registered as a decrease in FSP...... indicates an increase of digital arterial tone. In all three groups, digital arterial tone increased more than in normals during finger cooling. Patients with Raynaud's disease showed a pathological increase in arterial tone at 23.5 degrees C with closure of the digital arteries at a mean temperature of 18.......5 degrees C. The temperature eliciting these phenomena in patients with thrombo-angiitis obliterans was about 7 degrees C lower (16.5 and 11.0 degrees C, respectively). Accordingly, cold sensitivity and Raynaud's phenomena in the two groups may have a different pathophysiological mechanism, namely...

  2. Carcinoma de pene y liquen escleroso: dos entidades estrechamente relacionadas

    OpenAIRE

    H. Hernández; Bielsa, O; Lloreta, Josep; Del Canto, M.; Esgueva, R.; J.A. Lorente; Arango O.

    2008-01-01

    El liquen escleroatrófico (LS) o Balanitis xerótica obliterans es un transtorno crónico de la piel de causa desconocida que puede aparecer en la región genital sobre todo en varones de mediana edad no circuncidados y que se relaciona con el cáncer de pene. Su incidencia varía en función de las series

  3. Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

    Directory of Open Access Journals (Sweden)

    Annie M Bérard

    Full Text Available BACKGROUND: This study aimed to determine the prevalence of genetic and environmental vascular risk factors in non diabetic patients with premature peripheral arterial disease, either peripheral arterial occlusive disease or thromboangiitis obliterans, the two main entities of peripheral arterial disease, and to established whether some of them are specifically associated with one or another of the premature peripheral arterial disease subgroups. METHODS AND RESULTS: This study included 113 non diabetic patients with premature peripheral arterial disease (diagnosis <45-year old presenting either a peripheral arterial occlusive disease (N = 64 or a thromboangiitis obliterans (N = 49, and 241 controls matched for age and gender. Both patient groups demonstrated common traits including cigarette smoking, low physical activity, decreased levels of HDL-cholesterol, apolipoprotein A-I, pyridoxal 5'-phosphate (active form of B6 vitamin and zinc. Premature peripheral arterial occlusive disease was characterized by the presence of a family history of peripheral arterial and carotid artery diseases (OR 2.3 and 5.8 respectively, 95% CI, high lipoprotein (a levels above 300 mg/L (OR 2.3, 95% CI, the presence of the factor V Leiden (OR 5.1, 95% CI and the glycoprotein Ia(807T,837T,873A allele (OR 2.3, 95% CI. In thromboangiitis obliterans group, more patients were regular consumers of cannabis (OR 3.5, 95% CI and higher levels in plasma copper has been shown (OR 6.5, 95% CI. CONCLUSIONS: According to our results from a non exhaustive list of study parameters, we might hypothesize for 1 a genetic basis for premature peripheral arterial occlusive disease development and 2 the prevalence of environmental factors in the development of thromboangiitis obliterans (tobacco and cannabis. Moreover, for the first time, we demonstrated that the 807T/837T/873A allele of platelet glycoprotein Ia may confer an additional risk for development of peripheral

  4. 小儿闭塞性细支气管炎1例报道

    Institute of Scientific and Technical Information of China (English)

    房中华; 王雪峰

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,在儿童中是一种相对少见而严重的慢性阻塞性肺病。我院采用中西医结合疗法治愈BO1例,报道如下。

  5. Acute chemical pneumonitis caused by nitric acid inhalation: case report

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Hyung Shim; Lee, In Jae; Ko, Eun Young; Lee, Jae Young; Kim, Hyun Beom; Hwang, Dae Hyun; Lee, Kwan Seop; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2003-06-01

    Chemical pneumonitis induced by nitric acid inhalation is a rare clinical condition. The previously reported radiologic findings of this disease include acute permeability pulmonary edema, delayed bronchiolitis obliterans, and bronchiectasis. In very few published rare radiologic reports has this disease manifested as acute alveolar injury; we report a case of acute chemical pneumonitis induced by nitric acid inhalation which at radiography manifested as bilateral perihilar consolidation and ground-glass attenuation, suggesting acute alveolar injury.

  6. ENFERMEDAD DE BUERGER

    OpenAIRE

    2011-01-01

    Thromboangiitis obliterans also known asBuerger’s Disease is a segmental, inflammatory,occlusive, non-atherosclerotic disease that involves small and medium caliber arteries, veinsand nerves; affects mainly young males withtobacco abuse history.The clinical presentation is caused for the occlusion and stenosis of the distal vasculature in upper and lower limbs. The initial ischemicsymptoms are intermittent claudication in theaffected extremities. In the natural history of thedisease, patients...

  7. Water Flow through Xylem: An Investigation of a Fluid Dynamics Principle Applied to Plants

    Science.gov (United States)

    Rice, Stanley A.; McArthur, John

    2004-01-01

    A study was conducted to prove that a large blood or xylem vessel could conduct 256 times more fluid than a vessel or a pipe that is four times smaller. The result of this study proved that if arteriosclerosis causes an artery to loose half its effective diameter, the blood flow would be reduced by fifteen-sixteenths.

  8. Doppler-ultralydundersøgelse af underekstremitetsarteriosklerose

    DEFF Research Database (Denmark)

    Rørdam, P; von Jessen, F; Sillesen, H H;

    1992-01-01

    Arteriography, which requires resources and is not entirely without risk, has hitherto been a prerequisite for reconstructive surgery in cases of symptom-producing arteriosclerosis in the lower limbs. As an alternative, indirect Doppler ultrasonic examination has been employed but does not appear...

  9. The Benefits of Health Maintenance.

    Science.gov (United States)

    Rosenstein, Alan H.

    1987-01-01

    The article focuses on the merits of a comprehensive, medically-oriented health maintenance/risk assessment program, and suggests that such conditions as heart disease, cancer, and arteriosclerosis can be prevented or postponed through proper nutrition, weight control, exercise, smoking cessation, and stress management. (Author/CB)

  10. Preventing and Treating Type 2 Diabetes through a Physically Active Lifestyle

    Science.gov (United States)

    Leung, Raymond W.; Kamla, Jim; Lee, Man-Cheong; Mak, Jennifer Y.

    2007-01-01

    The general decrease in physical activity in the United States population has led to an increase of cases of type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), obesity, dyslipidemia, hypertension, and arteriosclerosis. Remarkable scientific advancements have been made toward understanding the beneficial effects of physical activity…

  11. Ischemic pain in the extremities and Raynaud's phenomenon.

    NARCIS (Netherlands)

    Devulder, J.; Suijlekom, H. van; Dongen, R.T.M. van; Diwan, S.; Mekhail, N.; Kleef, M. van; Huygen, F.

    2011-01-01

    Two important groups of disorders result from an insufficient blood supply to the extremities: critical vascular disease and the Raynaud's phenomenon. The latter can be subdivided into a primary and a secondary type. Critical ischemic disease is often caused by arteriosclerosis due to hypertension o

  12. [Long-term evaluation of spinal cord electric stimulation in peripheral vascular disease].

    Science.gov (United States)

    Duato Jané, A; Lorente Navarro, C; Azcona Elizalde, J M; Revilla Martín, J M; Marsal Machín, T; Buisán Bardají, J M

    1993-01-01

    We reported an study about the Electric Medullar Stimulation on Peripheral Vascular Pathology, in cases of critical Ischaemia of lower limbs. Short-time and longtime results are exposed. Arteriopathies included into the study were: arteriosclerosis, "mixed arteriopathy and TAO". Examination was made by Doppler-Ultrasonography.

  13. Chlamydia in canine or feline coronary arteriosclerotic lesions

    Directory of Open Access Journals (Sweden)

    Grabarevic Zeljko

    2011-09-01

    Full Text Available Abstract Background There are numerous reports linking Chlamydia infection to human coronary atherosclerosis. However, there is a lack of data regarding this correlation in dogs and cats, and there are no reports investigating coronary arteriosclerosis and Chlamydia in these species. The aim of the present study was to examine whether there is a correlation between canine and feline spontaneous atherosclerosis or arteriosclerosis and the presence of Chlamydia. Archived histopathological samples of dogs (n = 16 and cats (n = 13 with findings of atherosclerosis or arteriosclerosis in heart tissue were examined for the presence of Chlamydiaceae using real-time PCR, ArrayTube Microarray and immunohistochemistry. Additionally, arteriosclerotic lesions of all cases were histologically classified and graded. Results Both canine atherosclerotic cases, and all 14 canine arteriosclerotic cases were negative for Chlamydia. Only one of the 13 arteriosclerotic feline cases was positive for Chlamydia by real-time PCR, revealing C. abortus by ArrayTube Microarray. To our knowledge, this is the first description of C. abortus in a cat. Overall, the type and grade of canine and feline arteriosclerotic lesions revealed similarities, and were predominantly moderate and hyperplastic. Conclusions These findings suggest that there is no obvious correlation between canine and feline coronary arteriosclerosis and the presence of Chlamydia. In order to draw final conclusions about the correlation between Chlamydia and canine atherosclerosis, examination of more samples is required.

  14. Nature and origin of the neointima in whole vessel wall organ culture of the human saphenous vein

    NARCIS (Netherlands)

    Slomp, J.; Gittenberger - Groot, A.C. de; Munsteren, J.C. van; Huysmans, H.A.; Bockel, J.H. van; Hinsbergh, V.W.M. van; Poelmann, R.E.

    1996-01-01

    Intimal proliferation is a characteristic feature of arteriosclerosis. Whole vessel wall organ culture systems have been developed to study the early stages of neointima formation. We have cultured a large number of explants of human saphenous vein specimens for several weeks, and have identified th

  15. A Space-Time Finite Element Approach to the Numerical Simulation of Vascular Fluid-Solid Interaction

    NARCIS (Netherlands)

    Vlijm, E.J.; Van Brummelen, E.H.

    2008-01-01

    Numerical studies of cardiovascular diseases like arteriosclerosis have gained increasing attention the last decade. The modeling of blood, blood vessel and their coupling, shows to be a challenging problem. In this thesis a two-dimensional model has been constructed and its behaviour has been inves

  16. Relation of Serum Adiponectin Levels to Number of Traditional Atherosclerotic Risk Factors and All-Cause Mortality and Major Adverse Cardiovascular Events (from the Copenhagen City Heart Study)

    DEFF Research Database (Denmark)

    Lindberg, Soren; Mogelvang, Rasmus; Pedersen, Sune H;

    2013-01-01

    Adiponectin exerts anti-inflammatory and antiatherogenic effects and appears to protect against arteriosclerosis. Accordingly, an association between low concentrations of plasma adiponectin and cardiovascular (CV) disease has been demonstrated in several studies. In contrast, elevated plasma...... or nonfatal myocardial infarction or ischemic stroke (n = 502). High adiponectin was inversely associated with an increasing number of traditional CV risk factors (p...

  17. Genetic and bibliographic information: MNDA [GenLibi

    Lifescience Database Archive (English)

    Full Text Available MNDA myeloid cell nuclear differentiation antigen human atherosclerosis (MeSH) Card...iovascular Diseases (C14) > Vascular Diseases (C14.907) > Arterial Occlusive Diseases (C14.907.137) > Arteriosclerosis... (C14.907.137.126) > Atherosclerosis (C14.907.137.126.307) 05A0467425 ...

  18. Association of non-alcoholic fatty liver disease and coronary artery disease

    Directory of Open Access Journals (Sweden)

    Biswajit Majumder

    2016-10-01

    Conclusions: From our current study it can be reasonably said that NAFLD may be an independent risk factor for developing arteriosclerosis. This hypothesis should be verified with larger studies in different population groups. [Int J Res Med Sci 2016; 4(10.000: 4359-4364

  19. Relativity analysis of arterosclerotic cerebral infarction of senile patients and secondary epilepsy%老年动脉硬化性脑梗死与继发性癫痫相关性分析

    Institute of Scientific and Technical Information of China (English)

    张英杰; 马艳

    2001-01-01

    @@Background: Acute cerebral vascular secondary epilepsy isn't uncommon in clinic.It can happen at any time of epilepsy,even as first- onset or main clinical manifestation.Main cause of stroke of senile patients is arteriosclerosis,which is main cause of old stage epilepsy. Objective:To analyze relativity of arterosclerotic cerebral infarction of senile patients and secondary epilepsy.

  20. Aortic thrombus formation during a Seldinger aortography

    Energy Technology Data Exchange (ETDEWEB)

    Kiermayer, H.

    1984-12-01

    Acute aortic thrombosis is a rarely described complication of angiography with the technique of arterial catheterization. In the presented case record, a sudden therapy-resistant rise in blood pressure was accompanied by paraplegia of the lower limbs. The activation of the coagulation system caused by the heterogeneous material brought into the aorta, combined with severe arteriosclerosis, is discussed as a possible cause.

  1. Is pancreatic polypeptide response to food ingestion a reliable index of vagal function in type 1 diabetes?

    DEFF Research Database (Denmark)

    Damholt, M B; Arlien-Soeborg, P; Hilsted, L

    2006-01-01

    The diagnosis of autonomic neuropathy in diabetic patients is based on cardiovascular reflex tests. Since cardiac function may be affected by arteriosclerosis and cardiomyopathy in type 1 diabetes mellitus, alternative tests reflecting vagal nerve function, in other organ systems, are needed...

  2. [Diabetes mellitus and periodontal disease].

    Science.gov (United States)

    Sliz, Monika; Olszewska-Czyz, Iwona; Kantorowicz, Malgorzata; Chomyszyn-Gajewska, Maria

    2013-01-01

    Scientific studies confirm correlation between periodontitis and systemic diseases such as: arteriosclerosis, diabetes, heart diseases, stroke, diseases of the respiratory system, kidney diseases, osteoporosis, rheumatoid arthritis, premature birth and low birth weight. The interaction between periodontitis and diabetes mellitus is described, based on the literature.

  3. Characteristic analysis of secondary epileptic attack of senile arteriosclerotic cerebral infarction%老年人动脉硬化性脑梗死继发癫痫发作的特点分析

    Institute of Scientific and Technical Information of China (English)

    曹绪政; 兰杰; 徐建民; 邱朝晖

    2002-01-01

    Senile cerebral apoplexy is mainly caused by arteriosclerosis, which is also an important reason to epileptic attack. We analyzed clinical data of 1 383 in patient cerebral infarction cases from 211th Hospital of PLA from January 1996 to October 2001 in which there were 79 secondary epileptic attack of senile arteriosclerotic cerebral infarction.Results were shown followed.

  4. Shock in the Nonhuman Primate. Volume 2. Abstracts of the Published Literature, 1974-1977

    Science.gov (United States)

    1977-06-01

    necrosis and formation of large multivesicular bodies and fat droplets occurred in parenchymal cells. The space of Disse was frequently obliterated by...compensating for the cardiovascular insult. In some patients, however, such as the elderly person who may have antecedent heart disease, arteriosclerosis or

  5. Late Effects of Total-Body Roentgen Irradiation. Longevity and Incidence of Nephrosclerosis as Influenced by Partial-Body Shielding

    Science.gov (United States)

    1959-05-01

    postirradiation with complete obliteration oi the capillary developed this lesion (table III). Nephrosclero- tufts (3). sis was nearly absent during the 17.5...the human species. We have not ob- these organs are not yet complete. Possiblyserved significant arteriosclerosis of large irradiation of the kidneys

  6. Transgenetic Animal Model in Studying Blood Fat Metabolism%血脂类代谢研究中的转基因动物模型

    Institute of Scientific and Technical Information of China (English)

    卢笑丛; 王有为

    2003-01-01

    Transgenic animal model for diseases established to show diversified disease through the expression or excessiveexpression of gene. The lipid metabolizing is very a complex physiological process in human. During the gene-relating lipid metabolizing, it includes the factors of causing arteriosclerosis formed and the factors of reducing arteriosclerosis attack. This paper described the transgenic animal model and its characters of gene of aplipoprotein (Apo) such as ApoE,ApoA, ApoB, ApoC, receptor gene sweeping receptor SR-A, SR-B and SR-CD, gene of lipid metabolizing enzyme,gene of transprotein such as CETP, LPL etc. Those transgenic animal models play an important role in studying disease mechanism, drug screening, gene treatment and in producing the protein as drug using.

  7. Application of a four-channel vibrometer system for detection of arterial stiffness

    Science.gov (United States)

    Campo, Adriaan; Waz, Adam; Dudzik, Grzegorz; Dirckx, Joris; Abramski, Krzysztof

    2016-06-01

    Cardiovascular diseases (CD) are the most important cause of death in the world and their prevalence is only rising. A significant aspect in the etiology of CD is the stiffening of the large arteries (arteriosclerosis) and plaque formation (atherosclerosis) in the common carotid artery (CCA) in the neck. As shown by increasing evidence, both conditions can be detected by assessing pulse wave velocity (PWV) in the CCA, and several approaches allow local detection of PWV, including ultrasound (US) and magnetic resonance imaging (MRI). In previous studies, laser Doppler vibrometry (LDV) was introduced as an approach to assess arterial stiffness. In the present work, a new, compact four-channel LDV system is used for PWV detection in four phantom arteries mimicking real life CCA conditions. The high sensitivity of the LDV system allowed PWV to be assessed, and even local changes in phantom architecture could be detected. This method has potential for cardiovascular screening, as it allows arteriosclerosis assessment and plaque detection.

  8. Border detection on Common Carotid Artery using Gauss-Markov Estimation

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility, high accuracy and high-speed. In this paper, we propose the high-accuracy and high-speed detection method by Gauss-Markov estimation. About high-accuracy, it realized by attaching importance to high reliable candidate point of border. And, about high-speed, it realized by calculating matrix only one time.

  9. Border Detection of Common Carotid Artery Using Hough Transform

    Science.gov (United States)

    Koya, Yoshiharu; Nagahara, Yoshihiro

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility and high accuracy. The conventional methods to detect the border curve depend on differential value of brightness on the common carotid artery. Therefore, we can't extract a good candidate point by influence of a noise. In this paper, we propose the high-accuracy detection method by Hough Transform. About high-accuracy, it realized by attaching importance to high reliable candidate point of border.

  10. Pharmacognostical and phytochemical evaluation of Cactus grandiflorus (L.) Britton and Rose

    OpenAIRE

    Rajat Rashmi; Divya Mishra

    2016-01-01

    Background: Cactus grandiflorus (L.) Britton and Rose, Family: Cactaceae is an evergreen shrub with creeping aerial roots, used in Homoeopathy for atheromatous arteries, angina pectoris, and constriction of heart muscles, endocarditis, and heart weakness due to arteriosclerosis. Flowering stems are used in the preparation of medicine. Objective: The pharmacognostic and phytochemical studies are carried out to facilitate identification of correct species and standardized raw materials. Materia...

  11. Puncture-ejection of own egg by Least Bell's Vireo and potential implications for anti-parasitism defense

    Science.gov (United States)

    Sharp, Bryan L.; Peterson, Bonnie L.; Kus, Barbara E.

    2005-01-01

    A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia.

  12. Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret

    Science.gov (United States)

    Carpenter, J.W.; Davidson, J.P.; Novilla, M.N.; Huang, J.C.M.

    1980-01-01

    A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia.

  13. A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

    DEFF Research Database (Denmark)

    Bendtzen, Klaus; Christensen, Ole; Nielsen, Claus Henrik

    2014-01-01

    When exposed to small amounts of bacterial endotoxin, matrices of cholesterol crystals, but not cholesterol itself, primed human monocytes/macrophages to a highly augmented (>10-fold) production of inflammatory tumor necrosis factor-α. Priming also sensitized the cells, as 10- to 100-fold lower...... suggest that cholesterol matrix formation may play a pathogenic role in atherosclerotic inflammation, and they indicate a mechanism by which bacteria and/or bacterial products may play a role in processes leading to arteriosclerosis....

  14. 皮质下动脉硬化性脑病CT与临床特征

    Institute of Scientific and Technical Information of China (English)

    邹苏予; 高广义

    2000-01-01

    @@ 皮质下动脉硬化性脑病(subcortex arteriosclerosis encephalopathy,SAE),又称Binswanger病,是血管性痴呆的一种特殊类型.本文结合我院诊治的47例SAE的CT表现和临床特征,就其病因、病理、诊断和智能障碍等相关因素进行初步分析.

  15. Correlation Factor Analysis of Retinal Microvascular Changes in Patients With Essential Hypertension

    Institute of Scientific and Technical Information of China (English)

    Huang Duru; Huang Zhongning

    2006-01-01

    Objectives To investigate correlation between retinal microvascular signs and essential hypertension classification. Methods The retinal microvascular signs in patients with essential hypertension were assessed with the indirect biomicroscopy lens, the direct and the indirect ophthalmoscopes were used to determine the hypertensive retinopathy grades and retinal arteriosclerosis grades.The rank correlation analysis was used to analysis the correlation these grades with the risk factors concerned with hypertension. Results Of 72 cases with essential hypertension, 28 cases complicated with coronary disease, 20 cases diabetes, 41 cases stroke,17 cases renal malfunction. Varying extent retinal arterioscleroses were found in 71 cases, 1 case with retinal hemorrhage, 2 cases with retina edema, 4 cases with retinal hard exudation, 5 cases with retinal hemorrhage complicated by hard exudation, 2 cases with retinal hemorrhage complicated by hard exudation and cotton wool spot, 1 case with retinal hemorrhage complicated by hard exudation and microaneurysms,1 case with retinal edema and hard exudation, 1 case with retinal microaneurysms, 1 case with branch retinal vein occlusion. The rank correlation analysis showed that either hypertensive retinopathy grades or retinal arteriosclerosis grades were correlated with risk factor lamination of hypertension (r=0.25 or 0.31, P<0.05), other correlation factors included age and blood high density lipoprotein concerned about hypertensive retinopathy grades or retinal arteriosclerosis grades, but other parameters, namely systolic or diastolic pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose,blood urea nitrogen and blood creatinine were not confirmed in this correlation analysis (P > 0.05).Conclusions Either hypertensive retinopathy grade or retinal arteriosclerosis grade is close with the hypertension risk factor lamination, suggesting that the fundus examination of patients with

  16. Host-Derived Smooth Muscle Cells Accumulate in Cardiac Allografts: Role of Inflammation and Monocyte Chemoattractant Protein 1

    OpenAIRE

    Piotr Religa; Grudzinska, Monika K; Krzysztof Bojakowski; Joanna Soin; Jerzy Nozynski; Michal Zakliczynski; Zbigniew Gaciong; Marian Zembala; Cecilia Söderberg-Nauclér

    2009-01-01

    Transplant arteriosclerosis is characterized by inflammation and intimal thickening caused by accumulation of smooth muscle cells (SMCs) both from donor and recipient. We assessed the relationship between clinical factors and the presence of host-derived SMCs in 124 myocardial biopsies from 26 consecutive patients who received hearts from opposite-sex donors. Clinical and demographic information was obtained from the patients' medical records. Host-derived SMCs accounted for 3.35+/-2.3% of ce...

  17. Clinical Observation on Acupuncture Treatment of Cerebrovascular Dementia- A Report of 32 Cases

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Cerebrovascular dementia is a common disease in the middle-aged and old people. Its incidence makes up about 10-20% of all kinds of dementia. It is mainly caused by general degeneration of the brain function resulted from cerebral arteriosclerosis and cerebral infarction. The author has treated 32 cases of cerebrovascular dementia with acupuncture in the recent years with satisfactory therapeutic results. A report follows.

  18. Medial arterial calcification, calcific aortic stenosis and mitral annular calcification in a diabetic patient with severe autonomic neuropathy.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Medial arterial calcification (Monckeberg\\'s arteriosclerosis) is well described in diabetic patients with autonomic neuropathy. There is also a high prevalence of diabetes mellitus among subjects with calcific aortic stenosis and mitral annular calcification. We describe a diabetic patient with autonomic neuropathy and extensive medial arterial calcification who also had calcification of the aortic valve and of the mitral valve annulus. We propose that autonomic neuropathy may play a role in calcification of these structures at the base of the heart.

  19. Late Failing Heart Allografts: Pathology of Cardiac Allograft Vasculopathy and Association With Antibody-Mediated Rejection.

    Science.gov (United States)

    Loupy, A; Toquet, C; Rouvier, P; Beuscart, T; Bories, M C; Varnous, S; Guillemain, R; Pattier, S; Suberbielle, C; Leprince, P; Lefaucheur, C; Jouven, X; Bruneval, P; Duong Van Huyen, J P

    2016-01-01

    In heart transplantation, there is a lack of robust evidence of the specific causes of late allograft failure. We hypothesized that a substantial fraction of failing heart allografts may be associated with antibody-mediated injury and immune-mediated coronary arteriosclerosis. We included all patients undergoing a retransplantation for late terminal heart allograft failure in three referral centers. We performed an integrative strategy of heart allograft phenotyping by assessing the heart vascular tree including histopathology and immunohistochemistry together with circulating donor-specific antibodies. The main analysis included 40 explanted heart allografts patients and 402 endomyocardial biopsies performed before allograft loss. Overall, antibody-mediated rejection was observed in 19 (47.5%) failing heart allografts including 16 patients (40%) in whom unrecognized previous episodes of subclinical antibody-mediated rejection occurred 4.5 ± 3.5 years before allograft loss. Explanted allografts with evidence of antibody-mediated rejection demonstrated higher endothelitis and microvascular inflammation scores (0.89 ± 0.26 and 2.25 ± 0.28, respectively) compared with explanted allografts without antibody-mediated rejection (0.42 ± 0.11 and 0.36 ± 0.09, p = 0.046 and p < 0.0001, respectively). Antibody-mediated injury was observed in 62.1% of failing allografts with pure coronary arteriosclerosis and mixed (arteriosclerosis and atherosclerosis) pattern, while it was not observed in patients with pure coronary atherosclerosis (p = 0.0076). We demonstrate that antibody-mediated rejection is operating in a substantial fraction of failing heart allografts and is associated with severe coronary arteriosclerosis. Unrecognized subclinical antibody-mediated rejection episodes may be observed years before allograft failure.

  20. Homocysteine and atheromatosis

    Institute of Scientific and Technical Information of China (English)

    洪梅

    2006-01-01

    @@ Homocysteine (Hcy) was first linked with atherosclerosis over more than 30 years ago. McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma Hcy concentrations and homocystinuria in 1969. On the basis of this clinical observation, he put forward the Hcy theory of arteriosclerosis. Subsequent investigations HHcy have confirmed the association between and premature atherosclerosis of the coronary, cerebrovascular, and peripheral vascular beds.

  1. Relationship between vascular endothelial function and pulse wave velocity in prehypertension

    Institute of Scientific and Technical Information of China (English)

    杨娉婷

    2014-01-01

    Objective To investigate the association between vascular endothelial function and arteriosclerosis in prehypertensive,hypertensive and healthy subjects.Methods 810 consecutive subjects were divided into three groups:hypertension group,prehypertension group and control group.Brachial-ankle pulse wave velocity(ba PWV)and flow-mediated brachial artery dilation(FMD)were used to evaluate the artery vascular stiffness and endothelial function respectively.Results Prehypertension

  2. Karakterisasi Simplisia Dan Skrining Fitokimia Serta Isolasi Steroid/Triterpenoid Dari Ekstrak Etanol Pucuk Labu Siam (Sechium edule (Jacq.) Sw.)

    OpenAIRE

    Tarziah

    2013-01-01

    One of the Cucurbitaceou plans is chayote (Sechium edule (Jacq.) Sw.). used to treat kidney stone disease, arteriosclerosis and high blood pressure that contains saponin, flavonoid, polyphenol, and steroid/triterpenoid. Simplex characterization and chemical content contained in chayote shoots are not listed in the book Materia Medika Indonesia. The purpose of this study was to determine the simplex characterization, phytochemical screening for compounds that contained in chayote shoots and is...

  3. Calcificación vascular asociada a inflamación : influencia de la vitamina D

    OpenAIRE

    Guerrero Pavón, Fátima

    2012-01-01

    Arteriosclerosis y aterosclerosis son procesos comunes en los pacientes con enfermedad renal crónica (ERC). De hecho, la calcificación vascular (CV) representa un importante factor de riesgo que contribuye a la alta tasa de mortalidad cardiovascular asociada a la ERC. En pacientes urémicos, la CV está causada, en parte, por alteraciones en el metabolismo mineral estrechamente relacionadas con el control del hiperparatiroidismo secundario (HPT2º). Los pacientes con ERC muestr...

  4. Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency

    OpenAIRE

    Pérez-Sieira, S.; M. López(Universidad Complutense, Madrid, Spain); Nogueiras, R.; Tovar, S.

    2014-01-01

    The NR4A is a subfamily of the orphan nuclear receptors (NR) superfamily constituted by three well characterized members: Nur77 (NR4A1), Nurr1 (NR4A2) and Nor 1 (NR4A3). They are implicated in numerous biological processes as DNA repair, arteriosclerosis, cell apoptosis, carcinogenesis and metabolism. Several studies have demonstrated the role of this subfamily on glucose metabolism, insulin sensitivity and energy balance. These studies have focused mainly in liver and skeletal muscle. Howeve...

  5. Not at random location of atherosclerotic lesions in thoracic aorta and their prognostic significance in relation to the risk of cardiovascular events.

    Science.gov (United States)

    Wasilewski, Jarosław; Głowacki, Jan; Poloński, Lech

    2013-04-01

    Thoracic aortic calcium deposits are frequently detected on tomography of the chest, and in other imaging modalities. Numerous studies indicated the correlation of hemodynamic parameters such as wall shear stress in relation to distribution aortic calcifications. This publication discusses similarities and differences of two distinct pathomechanisms of arterial calcifications: intimal associated with atherosclerosis and medial knows as Mönckeberg's arteriosclerosis. This review also analyzes the frequent coexistence of aortic calcification and coronary artery disease in terms of risk of cardiovascular events.

  6. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  7. Relationships among Ocular Blood Flow Shown by Laser Speckle Flowgraphy, Retinal Arteriosclerotic Change, and Chorioretinal Circulation Time Obtained by Fluorescein Angiography

    Science.gov (United States)

    Itokawa, Takashi; Hori, Yuichi

    2017-01-01

    Purpose. To determine the correlations among the mean blur rate (MBR) in the optic nerve head (ONH) shown by laser speckle flowgraphy (LSFG), retinal arteriosclerosis, and the circulation time obtained by fluorescein angiography (FA). Method. We evaluated 118 patients and assessed their time of choroidal flush, arm-to-retina time, and early and late phases of retinal circulation time (RT: sec) obtained by FA. The severity of retinal arteriosclerosis was classified according to the Scheie classification. The MBR values throughout the ONH (MBR-A), in the tissue (MBR-T), and in the vessels (MBR-V) were analyzed. Results. Patients with retinal vein occlusion (RVO) showed prolonged early and late phases of RT compared to other ocular diseases. Single and multiple regression analyses showed that the MBR-V and Scheie classification were significantly associated with both the choroidal flush and arm-to-retina times. The incidences of RVO and MVR-V were significantly associated with the early phase of RT, and the incidences of RVO, MBR-V, Scheie classification, and gender were revealed to be factors independently contributing to the late phase of RT. Conclusion. MBR-V in the ONH and retinal arteriosclerosis are important contributing factors for the circulation time of each stage obtained by FA.

  8. Relationships among Ocular Blood Flow Shown by Laser Speckle Flowgraphy, Retinal Arteriosclerotic Change, and Chorioretinal Circulation Time Obtained by Fluorescein Angiography

    Directory of Open Access Journals (Sweden)

    Hironori Osamura

    2017-01-01

    Full Text Available Purpose. To determine the correlations among the mean blur rate (MBR in the optic nerve head (ONH shown by laser speckle flowgraphy (LSFG, retinal arteriosclerosis, and the circulation time obtained by fluorescein angiography (FA. Method. We evaluated 118 patients and assessed their time of choroidal flush, arm-to-retina time, and early and late phases of retinal circulation time (RT: sec obtained by FA. The severity of retinal arteriosclerosis was classified according to the Scheie classification. The MBR values throughout the ONH (MBR-A, in the tissue (MBR-T, and in the vessels (MBR-V were analyzed. Results. Patients with retinal vein occlusion (RVO showed prolonged early and late phases of RT compared to other ocular diseases. Single and multiple regression analyses showed that the MBR-V and Scheie classification were significantly associated with both the choroidal flush and arm-to-retina times. The incidences of RVO and MVR-V were significantly associated with the early phase of RT, and the incidences of RVO, MBR-V, Scheie classification, and gender were revealed to be factors independently contributing to the late phase of RT. Conclusion. MBR-V in the ONH and retinal arteriosclerosis are important contributing factors for the circulation time of each stage obtained by FA.

  9. Use of antiplatelet agents and anticoagulants for cardiovascular disease: current standards and best practices.

    Science.gov (United States)

    Faxon, David P

    2005-01-01

    Thrombosis superimposed on arteriosclerosis is the principal cause of mortality and morbidity in patients with arteriosclerosis. The use of antiplatelet agents and anticoagulants in the treatment of arteriosclerosis is well established, based on many large randomized trials. Aspirin is indicated for primary prevention in patients at increased risk of developing symptomatic atherosclerotic vascular disease. For patients with known vascular disease, antiplatelet therapy with aspirin is a well-established treatment. For high-risk patients such as those with acute coronary syndromes (ACS; unstable angina, myocardial infarction), dual antiplatelet therapy with aspirin and clopidogrel is indicated, based on results of the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial. Platelet glycoprotein IIb/IIIa agents are powerful inhibitors of platelet function and are also effective in ACS, but the benefit is confined to high-risk patients. Anticoagulation with heparin or low-molecular-weight heparin (eg, enoxaparin) is also effective, with an approximately 50% reduction in cardiovascular events. These agents are also indicated for patients undergoing percutaneous coronary intervention. Prolonged dual antiplatelet therapy (at least 6 months) is recommended for patients receiving drug-eluting stents. The efficacy of antiplatelet therapy is thus well established in treating atherothrombosis, but aggressive therapy is associated with an increased bleeding risk. Newer agents may provide improved efficacy with a lower risk of bleeding.

  10. Lithium battery hazard: old-fashioned planning implications of new technology.

    Science.gov (United States)

    Ducatman, A M; Ducatman, B S; Barnes, J A

    1988-04-01

    Lithium battery technology has important military applications and will increasingly enter the civilian marketplace. In order to prevent explosive fragmentation under some circumstances of malfunction or misuse, lithium batteries are designed to vent externally in the event of malfunction. Depending on the chemistry and size of a venting lithium battery, the release of toxic gases such as sulfur dioxide or thionyl chloride may pose risks to exposed individuals, particularly in enclosed spaces. Chemical and thermal burns, laryngeal edema, pulmonary edema, and bronchiolitis obliterans are potential outcomes. A case report is presented which illustrates the hazards. The hazards are not from unpredictable outcomes, but from failure to plan for predictable outcomes.

  11. Treating Principles and Methods of Traditional Chinese Medicine in Treatment of Peripheral Vascular Diseases

    Institute of Scientific and Technical Information of China (English)

    张雅洁; 陈知行; 刘玉洁; 张雅琳

    2001-01-01

    @@Peripheral vascular disease embraces a variety of conditions such as thromboangiitis obliterans, Raynaud's disease, thrombophlebitis, aorto-arteritis, obliterate atherosclerosis, varix or phlebothrombosis of the lower limb. Although the affected blood vessel may be arterial or venous one and caused either by inflammation or degenerate changes, they share common symptoms and signs, such as blood stasis, ischemia, thrombosis, ecchymosis, swelling, constriction or obliteration of blood vessels due to circulatory impairment. Since they share common characteristics, the treating principles and methods will be discussed as follows.

  12. [Clinical single case study (n-of-1 trial)].

    Science.gov (United States)

    Speich, R

    1998-09-01

    We conducted a single case (N-of-1) randomized trial in two patients. In the first case with bronchiolitis obliterans after lung transplantation a beneficial effect of inhaled steroids could be documented. The second patient suffered from symptoms compatible with HIV-associated M. Addison improving after cortisone, but the adrenocortical function was normal. Because the patient required the cortison treatment to be continued, we performed a n-of-1 trial which demonstrated the inefficacy of cortisone. This experience underscores the feasibility and usefulness of N-of-1 randomized clinical trials in medical practice.

  13. Representaciones de Santiago en Huellas de Siglo de Carmen Berenguer: La ciudad burdel

    OpenAIRE

    Magda Sepúlveda

    2008-01-01

    La ciudad Inserta en los flujos del capitalismo fue comparada por Baudelalre, y su lector Benjamín, con la prostituta. En otro contexto, neoliberal y dictatorial, la poeta chilena Carmen Berenguer actualiza el tópico en Huellas de siglo (1986). Berenguer plantea que toda la ciudad se ha transformado en un burdel donde nada se sustrae a convertirse en mercancía, por tanto, la diferencia política y de clase se obliteran. La poeta muestra que, para llegar a esta nueva ciudadanía ideal de carácte...

  14. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher M.; Carlsen, Jørn;

    2010-01-01

    Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass slides......, and used these antigen microarrays to profile 48 human serum samples for immunoglobulin G (IgG) and IgM autoantibodies; 27 patients showed no or mild bronchiolitis obliterans syndrome (BOS; a clinical correlate of OB) and 15 patients showed medium to severe BOS. We now report that these BOS grades could...

  15. Aortic thrombosis in a patient with a late diagnosis of Behcet's disease

    Directory of Open Access Journals (Sweden)

    Ana Bittencourt Detanico

    2015-06-01

    Full Text Available Behcet's disease is form of systemic vasculitis of unknown etiology. One surprising feature is that arterial involvement is less common in this disease than venous forms, accounting for 1 to 7% of patients. In 7 to 30% of cases the vascular symptoms precede the clinical diagnosis of Behcet. We describe the case of a patient with Thromboangiitis Obliterans who was treated with lumbar sympathectomy and an aortobiiliac bypass. Around 1 year later he was diagnosed with Behcet's disease after presenting with oral ulcers, genital ulcers and scaling lesions on the hands.

  16. 慢性移植物抗宿主病的诊断和临床分级指南

    Institute of Scientific and Technical Information of China (English)

    李娅娜

    2006-01-01

    @@ 慢性移植物抗宿主病(graft-versus-host disease,GVHD)是异基因造血干细胞移植(hematopoietic cell transplantation,HCT)的主要并发症.其特征类似于自体免疫及其它免疫疾病的症状,如:硬皮病,S-综合征,原发胆汁性肝硬化,消耗病,闭塞性细支气管炎(bronchiolitis obliterans,BO),免疫性血细胞减少症,慢性免疫缺陷症.

  17. 儿童闭塞性细支气管炎二例并文献复习

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 赵津生

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是儿科临床少见的以进行性呼吸困难及气流受阻为特点的慢性阻塞性疾病.自1901年Lange首次报道至今,关于其发病机制、治疗及预后等仍未明确.现将我院近年诊断的2例患儿报道如下.

  18. Early experience with lung transplantation using donors after cardiac death.

    Science.gov (United States)

    Mason, David P; Murthy, Sudish C; Gonzalez-Stawinski, Gonzalo V; Budev, Marie M; Mehta, Atul C; McNeill, Ann M; Pettersson, Gösta B

    2008-05-01

    Lung transplantations that utilize donor organs after cardiac death (DCD) can substantially increase the number of available allografts for waiting recipients. Unfortunately, reported clinical outcomes are limited and widespread acceptance is slow. To further examine the potential of this modality, the results of 4 patients transplanted with DCD organs, implementing a protocol of controlled organ retrieval (Maastricht Classification III), were reviewed. There were no operative deaths; extracorporeal membrane oxygenation was required in 1 patient secondary to severe primary graft dysfunction. Three patients are alive and well at 4, 15 and 21 months; 1 patient died at 34 months with bronchiolitis obliterans syndrome, in part attributable to medication non-compliance.

  19. Politics, culture, and the legitimacy of disease: the case of Buerger's disease.

    Science.gov (United States)

    Lockwood, Stephen J; Bresler, Scott C; Granter, Scott R

    2016-09-01

    Thromboangiitis obliterans (TAO) or Buerger's disease is a rare form of vasculitis with distinctive clinical and pathological features that carries significant morbidity, often leading to amputation, and is strongly associated with tobacco smoking. Despite its distinctive clinicopathological characteristics, the existence of TAO as an entity sui generis was challenged for many years as it languished in relative obscurity. Then, as societal attitudes towards smoking changed, TAO not only became accepted as a disease entity, it quite literally became a poster child to illustrate the ills of smoking. Herein, we examine the history of TAO to illustrate the power of societal attitudes and politics in shaping medicine.

  20. Elective preterm delivery as a management option in cryptogenic organizing pneumonia.

    Science.gov (United States)

    Holder, Kelly L; Scardo, James A; Laye, M Ryan

    2011-06-01

    Bronchiolitis obliterans organizing pneumonia, now termed as cryptogenic organizing pneumonia (COP), is a fibrotic lung disease of the small airways with the potential to progress to end-stage lung disease. COP in pregnancy carries a high risk of maternal and neonatal complications and only two prior cases have been reported. This is the first case of pre-existing COP in pregnancy. We report a 16-year-old primigravid with COP who elected inpatient management and preterm delivery as a successful management option.

  1. A case of Buerger's disease.

    Science.gov (United States)

    Ambrosi, C N; Rapini, R P

    1993-03-01

    Buerger's disease (thromboangiitis obliterans) is an uncommon vascular occlusive disease most commonly affecting the lower extremities of young male tobacco smokers. We report the case of a thirty-five-year-old man who presented with nonhealing ulcerations of several toes. Arteriography revealed severe bilateral vascular occlusion. The patient failed to respond to intensive topical care, nifedipine, pentoxifylline, hyperbaric oxygen, intravenous antibiotics, and whirlpool. He continued to smoke, and eventually became septic, requiring amputations of his gangrenous left second toe and right leg below the knee.

  2. Bloom syndrome with lung involvement

    Directory of Open Access Journals (Sweden)

    Nair Girija

    2009-01-01

    Full Text Available We report a case of a 24-year old male presented with cough and breathlessness with diabetes mellitus and diagnosed as a case of bloom syndrome. He was a product of consanguineous marriage, having short stature, dolicocephaly, polydactyly, prominent nose with telangiectasia face. The respiratory system examination revealed bilateral coarse crepitations and wheezes and the chest X-ray revealed emphysema with right middle zone inhomogenous opacity. Also, CT thorax examination revealed bilateral cystic bronchiectasis with bronchiolitis obliterans. Bloom′s syndrome was diagnosed on the basis of clinical features.

  3. Bloom syndrome with lung involvement.

    Science.gov (United States)

    Nair, Girija; Lobo, Ivona; Jayalaksmi, T K; Uppe, Abhay; Jindal, Savita; Chandra, Abhishek; Swami, Shivani

    2009-07-01

    We report a case of a 24-year old male presented with cough and breathlessness with diabetes mellitus and diagnosed as a case of bloom syndrome. He was a product of consanguineous marriage, having short stature, dolicocephaly, polydactyly, prominent nose with telangiectasia face. The respiratory system examination revealed bilateral coarse crepitations and wheezes and the chest X-ray revealed emphysema with right middle zone inhomogenous opacity. Also, CT thorax examination revealed bilateral cystic bronchiectasis with bronchiolitis obliterans. Bloom's syndrome was diagnosed on the basis of clinical features.

  4. 排尿障害を受診動機とする包茎を合併した高齢者乾燥性閉塞性亀頭炎の治療経験

    OpenAIRE

    2013-01-01

    Eight elderly patients (average age 76.1±4.3 years) with balanitis xerotica obliterans (BXO) accompanied by phimosis presented with difficulty in urination. Preoperative average international prostate symptom score, average maximum urinary flow rate, and average volume of residual urine were 20.7±6.3 points (n=8), 5.1±3.6 ml/s (n=5), and 85.4±77.3 ml (n=8), respectively. Some of the patient’s complaints, such as severe dribbling of urine, urinary stream division, and ballooning of the foreski...

  5. Treatment of Cytomegalovirus Infection with Cidofovir and CMV Immune Globulin in a Lung Transplant Recipient

    Directory of Open Access Journals (Sweden)

    Heinrike Wilkens

    2016-01-01

    Full Text Available Cytomegalovirus (CMV infection after lung transplantation is associated with increased risk for pneumonitis and bronchiolitis obliterans as well as allograft rejection and opportunistic infections. Ganciclovir is the mainstay of prophylaxis and treatment but CMV infections can be unresponsive. Apart from direct antiviral drugs, CMV immunoglobulin (CMVIG preparations may be considered but are only licensed for prophylaxis. A CMV-seronegative 42-year-old man with cystic fibrosis received a lung from a CMV-seropositive donor. Intravenous ganciclovir prophylaxis was delayed until day 12 due to acute postoperative renal failure and was accompanied by five doses of CMVIG (10 g. By day 16, CMV-DNA was detectable and rising; CMV-specific T-cells were undetectable. Switch from ganciclovir to foscarnet prompted a transient decrease in CMV viral load, but after increasing again to reach 3600 copies/mL foscarnet was changed to intravenous cidofovir and CMVIG was restarted. CMV load continued to fluctuate and declined slowly, whereas CMV-specific T-cells were detected five months later and increased thereafter. At last follow-up, the patient was in very good clinical condition with no evidence of bronchiolitis obliterans. No side effects of this treatment were observed. In this hard-to-treat case, the combination of cidofovir with off-label use of CMVIG contributed to a successful outcome.

  6. Risk factors for peripheral arterial disease in the tropics and its comparison with the western population

    Institute of Scientific and Technical Information of China (English)

    Myla Yacob; Edwin Stephen; Nupur Bit; Mazda Turel; David Sadhu; Sunil Agarwal

    2010-01-01

    Objective:To identify and compare the existence of similar and other risk factors in the perspective of an Indian population. Methods:It was designed as a case control study and was conducted in the Department of General and Vascular Surgery Unit 2 of Christian Medical College, Vellore, India between the periods July 2003 to June 2005. 100 patients with an ABPI<0.9 and 100 controls were studied. Results:Peripheral arterial disease (PAD) was found to be commoner among males (87%). While atherosclerosis was the commonest aetiology (54%), the incidence of Thromboangiitis Obliterans was also not uncommon (38%). Smoking was the main risk factor in the Indian context (83%) as compared to hypercholesterolemia (60%) in the West. The patients with atherosclerotic PAD were middle-aged and had concomitant diabetes (50%) and hypertension (30%). Conclusions:Peripheral arterial disease occurs in a relatively younger age group in India as compared to their Western counterparts. Thromboangiitis Obliterans was found to be a significant aetiology for arterial occlusive disease, with smoking as the primary risk factor followed by diabetes, hypertension and hypercholesterolemia.

  7. Mixed Herbal Medicine Induced Diffuse Infiltrative Lung Disease: The HRCT and Histopathologic Findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Gyu; Shin, Eun A [Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Joung Sook [Mokdong Hospital, Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    2010-12-15

    The purpose of this study was to evaluate the high-resolution CT (HRCT) and pathologic findings of mixed herbal medicine-induced diffuse interstitial lung disease. Eight patients (6 women and 2 men, age range: 31 to 81 years, mean age: 51.4 years) who presented with cough or dyspnea after taking mixed herbal medicine were included in this study. All the patients underwent plain chest radiography and HRCT. We obtained pathologic specimens from 7 patients via fluoroscopy guided large bore cutting needle biopsy and transbronchial lung biopsy. All the patients were treated with steroid therapy. The most common HRCT finding was bilateral diffuse ground glass opacity (n=7), followed by peribronchial consolidation (n=5) and inter- or intralobular septal thickening (n=2). For the disease distribution, the lower lung zone was dominantly involved. The pathologic results of 7 patients were nonspecific interstitial pneumonia (n=3), bronchiolitis obliterans organizing pneumonia (n=2), hypersensitivity pneumonitis (n=1) and eosinophilic pneumonia (n=1). Irrespective of the pathologic results, all 8 patients improved clinically and radiologically after steroid treatment. The HRCT findings of mixed herbal medicine-induced diffuse infiltrative lung disease were mainly bilateral diffuse ground glass opacity, peribronchial consolidation and dominant involvement of the lower lung zone. Those pathologic findings were nonspecific and the differential diagnosis could include interstitial pneumonia, bronchiolitis obliterans organizing pneumonia, hypersensitivity pneumonitis and eosinophilic pneumonia

  8. Bronchiolitis: adopting a unifying definition and a comprehensive etiological classification.

    Science.gov (United States)

    Papiris, Spyros A; Malagari, Katerina; Manali, Effrosyni D; Kolilekas, Likurgos; Triantafillidou, Christina; Baou, Katerina; Rontogianni, Dimitra; Bouros, Demosthenes; Kagouridis, Konstantinos

    2013-06-01

    Bronchiolitis is an inflammatory and potentially fibrosing condition affecting mainly the intralobular conducting and transitional small airways. Secondary bronchiolitis participates in disease process of the airways and/or the surrounding lobular structures in the setting of several already defined clinical entities, mostly of known etiology, and occurs commonly. Primary or idiopathic bronchiolitis dominates and characterizes distinct clinical entities, all of unknown etiology, and occurs rarely. Secondary bronchiolitis regards infections, hypersensitivity disorders, the whole spectrum of smoking-related disorders, toxic fumes and gas inhalation, chronic aspiration, particle inhalation, drug-induced bronchiolar toxicities, sarcoidosis and neoplasms. Idiopathic or primary bronchiolitis defines clinicopathologic entities sufficiently different to be designated as separate disease entities and include cryptogenic constrictive bronchiolitis, diffuse panbronchiolitis, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, neuroendocrine hyperplasia in infants, bronchiolitis obliterans syndrome in lung and allogeneic hematopoietic cell transplantation, connective tissue disorders, inflammatory bowel disease and bronchiolitis obliterans organizing pneumonia. Most of the above are pathological descriptions used as clinical diagnosis. Acute bronchiolitis, though potentially life threatening, usually regresses. Any etiology chronic bronchiolitis contributes to morbidity and/or mortality if it persists and/or progresses to diffuse airway narrowing and distortion or complete obliteration. Bronchiolitis in specific settings leads to bronchiolectasis, resulting in bronchiectasis.

  9. Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: Causes, CT-follow up and patient outcome

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Monika [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)]. E-mail: monika.vogel@med.uni-tuebingen.de; Brodoefel, Harald [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Bethge, Wolfgang [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Faul, Christoph [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Hartmann, Joerg [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Schimmel, Heiko [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Wehrmann, Manfred [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Claussen, Claus D. [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Horger, Marius [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)

    2006-12-15

    Objective: The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods: Patients with evidence of thoracic air-leakage, i.e. spontaneous pneumomediastinum, spontaneous pneumothorax or interstitial emphysema after allo-HCT were retrospectively identified by a chart review. Acute and follow-up morphology, duration and patient outcome were analyzed on CT (HRCT or MSCT with HR-reconstructions). Correlation was made with histological results of transbronchial biopsy. Results: The 6 patients included (3 male and 3 female, 14-64 years old) with thoracic air-leakage after allo-HCT all had histologically proven bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP). Thoracic air-leakage consisted of spontaneous pneumomediastinum associated with active invasive pulmonary aspergillosis (IPA) in 4/6 and spontaneous pneumothorax or interstitial emphysema each in 1/6 patients. Duration of thoracic air-leakage was 7-135 days. Of the patients with spontaneous pneumomediastinum, 3/4 died of IPA. One patient survived until complete regression of spontaneous pneumomediastinum. One patient died 7 days after spontaneous pneumothorax and one survived developing chronic interstitial emphysema. Conclusion: In all cases, thoracic air-leakage was associated to BO or BOOP. In the majority of cases with additional IPA, thoracic air-leakage is more indicative for severity of pulmonary disease than a life-threatening entity itself.

  10. An automated classification system for the differentiation of obstructive lung diseases based on the textural analysis of HRCT images

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seong Hoon; Seo, Joon Beom; Kim, Nam Kug; Lee, Young Kyung; Kim, Song Soo; Chae, Eun Jin [University of Ulsan, College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Lee, June Goo [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-07-15

    To develop an automated classification system for the differentiation of obstructive lung diseases based on the textural analysis of HRCT images, and to evaluate the accuracy and usefulness of the system. For textural analysis, histogram features, gradient features, run length encoding, and a co-occurrence matrix were employed. A Bayesian classifier was used for automated classification. The images (image number n = 256) were selected from the HRCT images obtained from 17 healthy subjects (n = 67), 26 patients with bronchiolitis obliterans (n = 70), 28 patients with mild centrilobular emphysema (n = 65), and 21 patients with panlobular emphysema or severe centrilobular emphysema (n = 63). An five-fold cross-validation method was used to assess the performance of the system. Class-specific sensitivities were analyzed and the overall accuracy of the system was assessed with kappa statistics. The sensitivity of the system for each class was as follows: normal lung 84.9%, bronchiolitis obliterans 83.8%, mild centrilobular emphysema 77.0%, and panlobular emphysema or severe centrilobular emphysema 95.8%. The overall performance for differentiating each disease and the normal lung was satisfactory with a kappa value of 0.779. An automated classification system for the differentiation between obstructive lung diseases based on the textural analysis of HRCT images was developed. The proposed system discriminates well between the various obstructive lung diseases and the normal lung.

  11. Lung transplantation in a Chinese single center:7 years of experience

    Institute of Scientific and Technical Information of China (English)

    HE Wen-xin; ZHANG Peng; LIU Ming; JIANG Ge-ning; DING Jia-an; GAO Wen; ZHU Yu-ming; ZHOU Xiao; CHEN Chang; WANG Hao; FAN Jiang

    2011-01-01

    Background Lung transplantation (LT) is a viable option for patients with end-stage lung diseases,but in China,the supply is limited,and the experience with LT is rare too. This study aimed to evaluate the survival and postoperative complications of recipients undergone LT.Methods From January 2003 to May 2010,all patients who underwent LT were included. The clinical data of recipients were analyzed retrospectively,including demographic characteristics,survival rate,and the occurrences of postoperative complications,acute rejection and bronchiolitis obliterans syndrome. Results In total,37 patients underwent LT. The early mortality (<30 days) was 14% (5/37). Cumulative survival rate was 78%,70%,70% and 42% at 1,3,5 and 6 years,respectively. In 37 patients,5 (14%) developed fungal infections,9 (24%)pulmonary bacterial infections,and 6 (16%) had bronchial anastomosis complications after LT. At three months posttransplantation,a significant improvement was observed in lung function (P <0.05). Fifteen recipients (41%) developed acute rejection within the first year. Freedom from bronchiolitis obliterans syndrome was 89%,85% and 80% at 1,2 and 3years after transplantation.Conclusions Despite the limited number of cases,the survival and occurrences of complications after LT were comparable to the international experience. Single LT may be a reasonable option for some patients with end-stage pulmonary diseases.

  12. Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children

    Directory of Open Access Journals (Sweden)

    EY Chan

    2005-01-01

    Full Text Available Idiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who presented to a tertiary care centre with recurrent episodes of respiratory distress on a background of baseline tachypnea, chronic hypoxemia and exertional dyspnea. Her past medical history revealed significant lung disease in infancy, including respiratory syncytial virus bronchiolitis and repaired gastroesophageal reflux. She was treated for 'asthma exacerbations' throughout her early childhood years. Bronchiolitis obliterans was subsequently diagnosed with an open lung biopsy. She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. Treatment options remain a dilemma for this patient because there is no known effective treatment for this condition, and the natural history is not well understood. The present case demonstrates the need for careful workup in 'atypical asthma', and the urgent need for further research into the rare lung diseases of childhood.

  13. Severe Organizing Pneumonia after Two Cycles of Docetaxel as Fourth-Line Chemotherapy for Advanced Non-Small Cell Carcinoma of the Lung

    Directory of Open Access Journals (Sweden)

    Jens Hasskarl

    2009-02-01

    Full Text Available Organizing pneumonia (formerly known as bronchiolitis obliterans organizing pneumonia, BOOP is an inflammatory process of the bronchioles that can lead to the destruction of small airways and surrounding lung tissue. Although the majority of cases are idiopathic, certain chemicals and drugs can induce OP. Here, we report a 54-year-old male patient with advanced non-small cell lung cancer (NSCLC who developed therapy-associated OP. He had undergone several other chemotherapies before being switched to docetaxel as monotherapy (75 mg/m2. Treatment was initially well tolerated, but after the second cycle the patient developed increasing shortness of breath. Computed tomography (CT for staging after the second cycle showed bilateral predominantly interstitial infiltration highly suggestive of acute lung fibrosis. Bronchoscopy revealed signs of chronic bronchitis and watery discharge from both lungs. Bronchoalveolar lavage and transbronchial needle biopsy was performed. Based on histopathologic examination, diagnosis of OP was made. After cessation of docetaxel and initial high dose steroids, the infiltration ameliorated rapidly. This is the second case in the literature that associates docetaxel with rapid onset of bronchiolitis obliterans. Therefore, patients with lung cancer receiving docetaxel who develop respiratory symptoms should be suspected to develop OP.

  14. Expiratory computed tomographic techniques: a cause of a poor rate of change in lung volume.

    Science.gov (United States)

    Morikawa, Keiko; Okada, Fumito; Mori, Hiromu

    2015-01-01

    Ninety-nine patients (29 males and 70 females; mean age, 57.1 years; range, 22-81 years) were included in this study to evaluate the factors affecting smaller lung volume changes in expiratory high-resolution computed tomography performed to depict air trapping. All patients underwent inspiratory and expiratory chest thin-section CT examinations and pulmonary function tests. Air trapping on CT images was graded subjectively. All variables (age, sex, diagnosis, pulmonary function index, and air trapping score) were compared with the degree of change in lung volume between the inspiratory and expiratory CT examinations. The variables affecting a lower degree of volume change were vital capacity, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1.0), and the FEV1.0/FVC ratio. Bronchiolitis obliterans was the dominant diagnosis in patients with insufficient degrees of breath holding and in patients with negative air trapping scores despite an abnormal air trapping index. An insufficient degree of lung changes between inspiration and expiration on CT examinations represented bronchiolitis obliterans, which resulted in low FEV1.0 and FEV1.0/FVC values. Changes in the time gap from the announcement of exhalation and breath holding to the start of scanning most effectively indicated air trapping in patients with bronchiolar disorders.

  15. Association between poor glycemic control, impaired sleep quality, and increased arterial thickening in type 2 diabetic patients.

    Directory of Open Access Journals (Sweden)

    Koichiro Yoda

    Full Text Available Poor sleep quality is an independent predictor of cardiovascular events. However, little is known about the association between glycemic control and objective sleep architecture and its influence on arteriosclerosis in patients with type-2 diabetes mellitus (DM. The present study examined the association of objective sleep architecture with both glycemic control and arteriosclerosis in type-2 DM patients.Cross-sectional study in vascular laboratory.The subjects were 63 type-2 DM inpatients (M/F, 32/31; age, 57.5±13.1 without taking any sleeping promoting drug and chronic kidney disease. We examined objective sleep architecture by single-channel electroencephalography and arteriosclerosis by carotid-artery intima-media thickness (CA-IMT.HbA1c was associated significantly in a negative manner with REM sleep latency (interval between sleep-onset and the first REM period (β=-0.280, p=0.033, but not with other measurements of sleep quality. REM sleep latency associated significantly in a positive manner with log delta power (the marker of deep sleep during that period (β=0.544, p=0.001. In the model including variables univariately correlated with CA-IMT (REM sleep latency, age, DM duration, systolic blood pressure, and HbA1c as independent variables, REM sleep latency (β=-0.232, p=0.038, but not HbA1c were significantly associated with CA-IMT. When log delta power was included in place of REM sleep latency, log delta power (β=-0.257, p=0.023 emerged as a significant factor associated with CA-IMT.In type-2 DM patients, poor glycemic control was independently associated with poor quality of sleep as represented by decrease of REM sleep latency which might be responsible for increased CA-IMT, a relevant marker for arterial wall thickening.

  16. Non-contrast magnetic resonance angiography in renal transplantation and renal donation

    DEFF Research Database (Denmark)

    Blankholm, Anne Dorte

    2015-01-01

    examination of living kidney donors. We compared CTA to an extensive MRI protocol without the use of contrast agents, including NCMRA, and to observations from living donor nephrectomy, which served as the reference standard. We concluded that an optimised MRI protocol without contrast agents could...... be substituted for CTA for preoperative vessel assessment in living kidney donors.......Renal transplantation is the treatment of choice in cases of severe renal disease. The majority of candidates for kidney transplantation have arteriosclerosis to some extent; thus, preoperative imaging of the vessels is needed. Different imaging modalities are available and are used...

  17. Observation on Efficiency of Jiangtang (降糖) Capsule in Treating Diabetes Mellitus Type 2 with Hyperlipidemia

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Arteriosclerosis is a major common vascular disorder of diabetes mellitus (DM), and as the life-span of DM patients prolonged, the incidence increased, arteriosclerotic coronary heart disease (CHD) and cerebrovascular diseases have become the principal causes of death of DM. Therefore, improving the disturbance of glucose and lipid metabolism, and preventing chronic complication are the key links in the treatment of DM. The authors used Jiangtang capsule (降糖胶囊, JTC) in treating DM type 2. While treating hypoglycemia, promising effect in improving lipid metabolism disturbance is also obtained. It is reported as follows.

  18. Simulation of Blood Flow at Vessel Bifurcation by Lattice Boltzmann Method

    Institute of Scientific and Technical Information of China (English)

    KANG Xiu-Ying; LIU Da-He; ZHOU Jing; JIN Yong-Juan

    2005-01-01

    @@ The application of the lattice Boltzmann method to the large vessel bifurcation blood flow is investigated in awide range of Reynolds numbers. The velocity, shear stress and pressure distributions at the bifurcation arepresented in detail. The flow separation zones revealed with increase of Reynolds number are located in theareas of the daughter branches distal to the outer corners of the bifurcation where some deposition of particularblood components might occur to form arteriosclerosis. The results also demonstrate that the lattice Boltzmannmethod is adaptive to simulating the flow in larger vessels under a high Reynolds number.

  19. Cuantificación de interleuquina 6 de tejidos periodontales

    OpenAIRE

    Rodríguez Gacharná, María Clemencia; López Páez, Consuelo

    2002-01-01

    Según el estudio de Morbilidad de Ministerio de Salud del año 1980 la enfermedad periodontal afecta en un 94 % la población colombiana y un 5% padece de las manifestaciones severas que pueden comprometer la vida del paciente afectando los sistemas como el cardiovascular, participando en la génesis del infarto del miocardio, arteriosclerosis, afectando el sistema respiratorio con episodios de neumonía, eventualmente ocasionando partos pretermino y nacimientos de bebés con bajo peso al nacer ...

  20. Peroxidación lipídica y factores de riesgo cardovascular

    OpenAIRE

    Plana Gil, Núria

    1993-01-01

    INTRODUCCIÓN: La lesión más incipiente que ha sido descrita en la patogénesis de la arteriosclerosis es la estría grasa. En este proceso los monocitos y los macrófagos juegan un papel muy importante. Los macrófagos no poseen receptores para las LDL negativas, sin embargo son capaces de reconocer las LDL modificadas a través del receptor scraveger. Ello provocará la entrada masiva de ésteres de colesterol en el interior de la célula, al no estar sujeta a ningún sistema de control, originando l...

  1. Associations between cardiac pathology and clinical, echocardiographic and electrocardiographic findings in dogs with chronic congestive heart failure

    DEFF Research Database (Denmark)

    Falk, Bo Torkel; Jönsson, Lennart; Olsen, Lisbeth Høier

    2010-01-01

    of fibrosis was associated with shorter survival time (P=0.002), and the papillary muscle fibrosis score tended to correlate with proximal isovelocity surface area radius (P=0.03). Data from this study lend support to the hypothesis that naturally occurring canine CHF is affected by several factors...... such as MMVD, myocardial atrophy and fibrosis, and by arteriosclerosis. Further, more extensive research will be required to establish cause-effect relationships between these cardiac lesions and the pathophysiology of CHF in dogs....

  2. Ultrasonic Imaging of Hemodynamic Force in Carotid Blood Flow

    Science.gov (United States)

    Nitta, N.; Homma, K.

    Hemodynamic forces including blood pressure and shear stress affect vulnerable plaque rupture in arteriosclerosis and biochemical activation of endothelium such as NO production. In this study, a method for estimating and imaging shear stress and pressure gradient distributions in blood vessel as the hemodynamic force based on viscosity estimation is presented. Feasibility of this method was investigated by applying to human carotid blood flow. Estimated results of shear stress and pressure gradient distributions coincide with the ideal distributions obtained by numerical simulation and flow-phantom experiment.

  3. Simulation of Blood Flow at Vessel Bifurcation by Lattice Boltzmann Method

    Science.gov (United States)

    Kang, Xiu-Ying; Liu, Da-He; Zhou, Jing; Jin, Yong-Juan

    2005-11-01

    The application of the lattice Boltzmann method to the large vessel bifurcation blood flow is investigated in a wide range of Reynolds numbers. The velocity, shear stress and pressure distributions at the bifurcation are presented in detail. The flow separation zones revealed with increase of Reynolds number are located in the areas of the daughter branches distal to the outer corners of the bifurcation where some deposition of particular blood components might occur to form arteriosclerosis. The results also demonstrate that the lattice Boltzmann method is adaptive to simulating the flow in larger vessels under a high Reynolds number.

  4. Health, wartime stress, and unit cohesion: evidence from Union Army veterans.

    Science.gov (United States)

    Costa, Dora L; Kahn, Matthew E

    2010-02-01

    We find that Union Army veterans of the American Civil War who faced greater wartime stress (as measured by higher battlefield mortality rates) experienced higher mortality rates at older ages, but that men who were from more cohesive companies were statistically significantly less likely to be affected by wartime stress. Our results hold for overall mortality, mortality from ischemic heart disease and stroke, and new diagnoses of arteriosclerosis. Our findings represent one of the first long-run health follow-ups of the interaction between stress and social networks in a human population in which both stress and social networks are arguably exogenous.

  5. Síntesis de pirido[2,3-d]pirimidin-7(8H)-onas 2-arilamino sustituidas y derivados

    OpenAIRE

    2013-01-01

    Les Cinases de Proteïna (PKs) estan implicades en processos fonamentals de la regulació del cicle cel•lular. L’acumulació d’anomalies als mecanismes de control i el comportament disfuncional que se’n deriva han estat detectats a cèl•lules de diferents teixits afectades per càncer, desordres immunològics, endocrins, nerviosos, neurodegenaratius, cardiovasculars, malalties infeccioses, diabetis, Alzheimer, asma, restenosi, arteriosclerosi, leucèmia, artritis, etc. Però d’entre totes les PKs, le...

  6. Estudio de la oxidación lipoproteica y marcadores de inflamación en pacientes con artritis reumatoide

    OpenAIRE

    Paredes González-Albo, Sílvia

    2004-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada La artritis reumatoide (AR) es una enfermedad inflamatoria cr_nica que se ha asociado a un incremento de enfermedad cardiovascular (ECV). La causa de este elevado riesgo de ECV no se conoce, se ha sugerido que la actividad inflamatoria de la AR pudiera dar lugar a una aterog_nesis acelerada. La arteriosclerosis es la causa subyacente de la ECV y se caracteriza por una acumulaci_n de lipoprote_nas apo B, matriz extracelul...

  7. Productos naturales que adelgazan... ¿una buena alternativa?

    OpenAIRE

    Alberto, Cecilia; Mallo, Andrea C.; Nitiu, Daniela S.

    1995-01-01

    La obesidad y otras enfermedades relacionadas como la arteriosclerosis y afecciones cardiovasculares, por una parte y la bulimia y anorexia, por otra, son temas de candente actualidad, tanto desde el punto de vista científico como social. El término adelgazar se define en la bibliografía médica como la pérdida de peso por causas naturales con eliminación, primero de agua y luego de grasa. En el pasado el concepto de salud era sinónimo de gordura; hoy en días se considera la obesidad como una ...

  8. Dr. Zhang's Experience in Massotherapy for Treatment of Vertebral-Artery-Type Cervical Spondylopathy

    Institute of Scientific and Technical Information of China (English)

    谢利民; 张涛

    2002-01-01

    @@ Thirty cases of vertebral-artery-type cervical spondylopathy were treated by Dr. Zhang Tao's technique. The cure rate was 50%, and the total effective rate was 100%.The vertebral-artery-type cervical spondylopathy is a commonly-seen condition in the aged people, often accompanied with arteriosclerosis. Based on the techniques performed by Dr. Du Ziming (the late famous TCM physician of our hospital), Dr. Zhang Tao has developed a set of therapeutic techniques for this condition. From June 1997 to April 1998, the author had treated 30 cases of the disease, with satisfactory results reported in the following.

  9. ¿Es la enfermedad periodontal un factor de riesgo para las enfermedades cardiovasculares? (I: Etiopatogenia y ensayos clínicos

    Directory of Open Access Journals (Sweden)

    J. Castro Lara

    Full Text Available El objetivo de los dos siguientes artículos es analizar los estudios existentes en la literatura sobre la asociación entre la enfermedad periodontal (EP y las enfermedades cardiovasculares (ECV con el fin de responder, desde la evidencia, a la pregunta de si la EP puede considerarse un factor que aumente la probabilidad de aparición de arteriosclerosis. La conclusión a la que se llega es que la EP podría ser un factor de riesgo para la ECV pero que aún se necesita más estudios experimentales para llegar a una evidencia causal.

  10. Insuficiencia arterial periférica en adultos jóvenes

    OpenAIRE

    Félix Patiño, José; Covelli, Víctor Hugo

    2011-01-01

    La insuficiencia arterial periférica, que en un altísimo porcentaje de casos es secundaria a procesos  degenerativos especialmente arteriosclerosis, es tal vez uno de los hallazgos clínicos más frecuentes en la población adulta de edad avanzada. Sus efectos, que van desde la simple molestia de la isquemia leve en los casos benignos, hasta la necrosis y gangrena de los casos severos, resultan en incapacidad y serias alteraciones funcionales. Bien conocida es la relación que existe entre esta c...

  11. A case study of technology transfer: Cardiology

    Science.gov (United States)

    Schafer, G.

    1974-01-01

    Research advancements in cardiology instrumentation and techniques are summarized. Emphasis is placed upon the following techniques: (1) development of electrodes which show good skin compatibility and wearer comfort; (2) contourography - a real time display system for showing the results of EKGs; (3) detection of arteriosclerosis by digital computer processing of X-ray photos; (4) automated, noninvasive systems for blood pressure measurement; (5) ultrasonoscope - a noninvasive device for use in diagnosis of aortic, mitral, and tricuspid valve disease; and (6) rechargable cardiac pacemakers. The formation of a biomedical applications team which is an interdisciplinary team to bridge the gap between the developers and users of technology is described.

  12. LIPOPROTEÍNAS DE BAJA DENSIDAD (LDL OXIDADAS

    Directory of Open Access Journals (Sweden)

    Pilar Calmarza Calmarza

    2008-01-01

    Full Text Available En los últimos años se ha consolidado la teoría oxidativa de la arteriosclerosis. En este proceso se produce el atrapamiento de ldl oxidadas en la íntima arterial.La medida de ldl oxidadas en el laboratorio es difícil, considerándose en la actualidad la medida de isoprostanos la técnica de elección para la valoración del estrés oxidativo.

  13. Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction

    DEFF Research Database (Denmark)

    Eskesen, Karen; János, Tajti; Tibor, Hortobágyi;

    2007-01-01

    -dependent change in total RNA and level of mRNA for p-actin or GAPDH could be detected in vessels removed from 1 and 5 days post mortem. The expression of beta-actin appears lower in coronary artery than in pulmonary artery and middle cerebral artery with no significant difference for GAPDH; both worked well......-R and RAMPs in arteries from patients with hemorrhagic stroke, arteriosclerosis and acute myocardial infarction when compared to patients without these diagnoses. Thus the mRNA expression seems to be unaltered in these disorders....

  14. Biofuncionalización de superficies de CoCr con nano-patterning

    OpenAIRE

    2015-01-01

    En este trabajo se estudia la modificación y caracterización superficial de una aleación de CoCr con aplicación para stens cardiovasculares. Un stent es un dispositivo que se introduce en las arterias coronarias para solucionar problemas como la estenosis o la arteriosclerosis, enfermedades que producen una obstrucción del vaso sanguíneo debido a la acumulación de placa en las paredes. Las enfermedades cardiovasculares son la mayor causa de mortalidad en los países desarrollados. Durante l...

  15. Biomarcadores de la inflamación en la diabetes mellitus tipo 2: Efecto del control glucémico y del fenotipo de las LDL

    OpenAIRE

    Vinagre Torres, Irene

    2014-01-01

    Las enfermedades cardiovasculares constituyen las complicaciones más prevalentes en los pacientes con diabetes mellitus tipo 2 (DM2) y son las que se asocian con mayor morbi-mortalidad. Los mecanismos responsables del desarrollo acelerado de arteriosclerosis en los pacientes con DM2 no se conocen con precisión, pero tanto la dislipemia aterogénica y la inflamación de bajo grado características de esta población, están implicados. La información sobre la relación del grado de control glucémico...

  16. Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve disease

    DEFF Research Database (Denmark)

    Falk, Bo Torkel; Jönsson, Lennart; Olsen, Lisbeth Høier;

    2006-01-01

    Background: The occurrence of small vessel arteriosclerosis in the myocardium, kidney, and lung in dogs with naturally occurring myxomatous mitral valve disease has not been previously investigated systematically. Methods: Twenty-one dogs with naturally occurring congestive heart failure and 21 age...... and pulmonary artery. Results: Dogs with congestive heart failure had significantly more arterial narrowing in the left ventricle (Pkidney (p...-matched, sex-matched, and weight-matched control dogs underwent extensive pathological and histopathological examination. Morphometry and scoring of tissue sections were used to measure arterial narrowing and fibrosis in the myocardium, kidney, and lung; and intimal thickness and plaque formation in the aorta...

  17. Marcadores de inflamación e insulinorresistencia en la hiperlipemia familiar combinada

    OpenAIRE

    Carratalá Calvo, Arturo

    2014-01-01

    La hiperlipemia familiar combinada (HFC) es un modelo genético de dislipemia mixta con resistencia a la insulina (RI) y elevado riesgo de cardiopatía isquémica por el desarrollo precoz de arteriosclerosis. La RI es independiente del grado de obesidad y del fenotipo lipoproteico. Constituye, además, factor de riesgo cardiovascular en estos pacientes. Actualmente existe una gran evidencia de que en el desarrollo y progresión de la aterosclerosis subyacen mecanismos inmunológicos e inflamator...

  18. Idiopathic great saphenous phlebosclerosis.

    Directory of Open Access Journals (Sweden)

    Ahmadreza Jodati

    2013-06-01

    Full Text Available Arterial sclerosis has been extensively described but reports on venous sclerosis are very sparse. Phlebosclerosis refers to the thickening and hardening of the venous wall. Despite its morphological similarities with arteriosclerosis and potential morbid consequences, phlebosclerosis has gained only little attention. We report a 72 year old male with paralysis and atrophy of the right leg due to childhood poliomyelitis who was referred for coronary artery bypass surgery. The great saphenous vein, harvested from the left leg, showed a hardened cord-like obliterated vein. Surprisingly, harvested veins from the atrophic limb were normal and successfully used for grafting.

  19. Measure and analyze the brachial-ankle pulse wave velocity of 125 plots%飞行员肢体动脉硬化与吸烟关系分析

    Institute of Scientific and Technical Information of China (English)

    单清; 王惠贤

    2011-01-01

    Objective : To explore the situation and related factors of the arteriosclerosis between the smoking pilots and non - smoking pilots. By means:125 pilots were randomly selected and divided into two groups: smoking group and non - smoking group. Measure the brachial - ankle pulse wave velocity of each pilot by Arteriosclerosis Checking Instrument , record the height , weight , systolic pressure , diastolic pressure , pulse pressure , driving plane period and smoking period of each pilot of the groups and compare the data of Bapwv of different ages between smoking pilots and non - smoking pilots. Results : There was little difference in Bapwv between the smoking pilots and non - smoking pilots with ages younger than 30 and 30 to 39( P >0. 05 ). The Bapwv of the smoking pilots who are over 40 years old are obvious higher than those same age non - smoking pilots( P < 0. 05 ). Conclusion: The brachial - ankle arteriosclerosis situation of the smoking pilots can be diagnosed correspondingly early. And we may prevent , interpose and doctor the arteriosclerosis of the smoking pilots to keep their flight safe.%目的:探讨飞行员肢体动脉硬化程度与吸烟关系.方法:随机选择125名飞行员分为吸烟组和非吸烟组,应用动脉硬化测定仪测定臂踝脉搏波传导速度,同时确定飞行员身高、体重、收缩压、舒张压、脉压、飞行时间等.对比各年龄段吸烟组与非吸烟组飞行员臂踝脉搏波传导速度.结果:30岁以下和30 ~39岁飞行员吸烟组臂踝脉搏波传导速度与非吸烟组无明显差异(P>0.05);40岁以上飞行员吸烟组臂踝脉搏波传导速度较非吸烟组显著升高(P<0.05).结论:通过对臂踝脉搏波传导速度的测定可以相对早期发现飞行员中特别是吸烟飞行员中动脉硬化程度,做到早预防、早干预,确保飞行安全.

  20. Cervical Spondylopathy Involving the Vertebral Arteries Treated by Body-Acupuncture Combined with Scalp-Acupuncture in 72 Cases

    Institute of Scientific and Technical Information of China (English)

    李保民; 柴富明; 高洪明

    2002-01-01

    @@ Among various types of cervical spondylopathy, the one involving the vertebral arteries is frequently encountered in the middle-aged and the old people. It is often accompanied with arteriosclerosis and high blood viscosity, and clinically it is difficult to be treated. From March 1996 to December 2000, the authors hadtreated 72 cases of cervical spondylopathy of this type and achieved satisfactory therapeutic effects shown by clinical symptoms and indicated by the trans-cranial Doppler ultrasonic examination (TCD). This is reported as follows.

  1. Dieta, estilos de vida y factores de riesgo cardiovascular en niños y adolescentes europeos

    OpenAIRE

    Bel Serrat, Silvia; Moreno Aznar, Luis Alberto; Krogh, Vittorio; Mouratidou, Theodora

    2014-01-01

    La infancia y la adolescencia no sólo se caracterizan por ser periodos de crecimiento rápido y maduración, sino también porque se adquiere el comportamiento alimentario para toda la vida. También se ha observado que las primeras manifestaciones de arteriosclerosis se dan de forma temprana durante la infancia y que, además, están relacionadas con la dieta y otros estilos de vida como la actividad física y los comportamientos sedentarios, entre otros factores. Por todo ello, es de gran importan...

  2. Prognostic significance of distal blood pressure measurements in patients with severe ischaemia

    DEFF Research Database (Denmark)

    Paaske, William; Tønnesen, K H

    1980-01-01

    The clinical course was followed and the ankle and toe blood pressures were measured with the strain gauge technique on 5 occasions during 2 years in 43 patients with pain at rest and/or ischaemic ulceration due to severe ischaemia of the legs on the basis of occlusive arterial disease. Although...... arteriosclerosis of the legs in non-diabetic patients is generally considered a benign disease from the standpoint of limb survival, the critical level of TPI (systolic toe blood pressure/systolic arm blood pressure) was found to be 0.07 as a TPI below this value was associated with an overall 82% risk...

  3. Caracterización de la actividad sexual en adultos mayores del policlínico Gustavo Aldereguía

    OpenAIRE

    Imilse Olivet López; Ángel Becerra Pérez; Norma Ávila Hernández

    2014-01-01

    Se realizó un estudio descriptivo de corte transversal, para caracterizar la sexualidad en adultos mayores pertenecientes al área de salud del policlínico “Gustavo Aldereguía Lima” del municipio de Las Tunas, en el período comprendido entre enero de 2012 y junio de 2013. De un universo de 151 adultos mayores se escogió una muestra de 111, se excluyeron los que poseían arteriosclerosis y demencia senil o que por razones invalidantes no mantuvieran relaciones sexuales, tales como: ancianos en e...

  4. Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects

    DEFF Research Database (Denmark)

    Blicher, M.; Kruger, R.; Olesen, Thomas Bastholm

    2015-01-01

    Objective: We wanted to test the impact of metabolic, hemodynamic and inflammatory factors on target organ damage (TOD) defined as cardiac hypertrophy, atherosclerosis, arterioclerosis and microvascular damage. Design and method: In a population based cohort study of 2115 healthy subjects (1049......SBP) and diastolic blood pressure (24hDBP), left ventricular mass index (LVMI) by M-mode echocardiography, carotid plaques (CP) by carotid ultra sound and carotid-femoral pulse wave velocity (PWV). To establish best model for association of LVMI, CP, PWV and UACR we used multiple linear regression analysis starting...... associated to hypertrophy, arteriosclerosis and microvascular damage in healthy subjects....

  5. Vasectomy.

    Science.gov (United States)

    Weiske, W H

    2001-05-01

    Vasectomy is regarded as the safest method now available for male fertility control. Almost 100 million men worldwide have relied on vasectomy for family planning. This review discusses all currently relevant operative techniques, including no-scalpel vasectomy, complications, possible long-term effects on the testis and epididymis, and diseases for which associations with vasectomy have been suggested, such as arteriosclerosis, autoimmune diseases and cancer of the prostate and testis. Other topics of discussion include the timing of post-operative semen analysis, patient noncompliance concerning post-operative controls, persistent cryptozoospermia and transient reappearance of spermatozoa after vasectomy, vasectomy failure and legal aspects.

  6. Subconjunctival hemorrhage: risk factors and potential indicators

    Directory of Open Access Journals (Sweden)

    Tarlan B

    2013-06-01

    Full Text Available Bercin Tarlan,1 Hayyam Kiratli21Department of Ophthalmology, Kozluk State Hospital, Batman, Turkey; 2Ocular Oncology Service, Hacettepe University Schoolof Medicine, Ankara, TurkeyAbstract: Subconjunctival hemorrhage is a benign disorder that is a common cause of acute ocular redness. The major risk factors include trauma and contact lens usage in younger patients, whereas among the elderly, systemic vascular diseases such as hypertension, diabetes, and arteriosclerosis are more common. In patients in whom subconjunctival hemorrhage is recurrent or persistent, further evaluation, including workup for systemic hypertension, bleeding disorders, systemic and ocular malignancies, and drug side effects, is warranted.Keywords: subconjunctival hemorrhage, contact lens, hypertension, red eye

  7. Histone deacetylases and atherosclerosis.

    Science.gov (United States)

    Zheng, Xia-xia; Zhou, Tian; Wang, Xin-An; Tong, Xiao-hong; Ding, Jia-wang

    2015-06-01

    Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam cells. Recently, the question about how to suppress the occurrence of atherosclerosis and alleviate the progress of cardiovascular disease becomes the hot topic. Accumulating evidence suggests that histone deacetylases(HDACs) play crucial roles in arteriosclerosis. This review summarizes the effect of HDACs and HDAC inhibitors(HDACi) on the progress of atherosclerosis.

  8. Arteria poplitea afklemningssyndrom

    DEFF Research Database (Denmark)

    Lyndrup, Peter; Meyer, Joan N; Schroeder, T V

    1994-01-01

    Popliteal artery entrapment syndrome (PAES) should be suspected in young persons without predisposing factors to arteriosclerosis, who present with unilateral claudication in the calf and foot. This entity results from a developmental abnormal relation between the popliteal artery and the medial...... head of the gastrocnemius muscle. PAES is mostly found in young sportsmen or young soldiers with well-developed muscles. The onset of the symptoms is often sudden, occurring during an episode of intense lower extremity activity. The diagnosis is best established by a thorough clinical examination...

  9. Alteraciones metabólicas de la Hiperlipemia Familiar Combinada y su asociación con la obesidad abdominal y la inflamación de bajo grado

    OpenAIRE

    Díaz Ruiz, María

    2015-01-01

    La HFC es un síndrome dislipémico descrito por Goldstein et al en 1973 identificado al estudiar a jóvenes supervivientes de un infarto agudo de miocardio y a sus familias. Observaron en ellos diferentes fenotipos metabólicos y lipoproteicos, con presencia de elevaciones de los niveles de colesterol total y/o triglicéridos, junto con elevación de lipoproteínas VLDL, de LDL, o de ambas lipoproteínas. La HFC presenta el desarrollo de arteriosclerosis como la manifestación clínica responsable de...

  10. Lung and heart lung transplantation at the University of Alberta 1986-2010.

    Science.gov (United States)

    Lien, Dale C; Weinkauf, Justin; Jackson, Kathleen; Kapasi, Ali; Nador, Roland; Meyer, Steven; Stewart, Kenneth; Modry, Dennis; Mullen, John

    2010-01-01

    The lung transplantation program at the University of Alberta has been in existence for 25 years. The current volume is 35-40 new lung transplants per year. We offer single-lung, bilateral lung, heart/lung and bilateral living lobar transplantation as options. Experience has allowed for widening of the indications and acceptance of patients with more risk. Donor evaluation and management has allowed for extended donors to be included in the donor pool. Results will likely continue to improve with increased understanding of the mechanisms and management of bronchiolitis obliterans syndrome. Our research interests have been in the areas of risk analysis, outcome assessment, and quality of life changes from transplantation.

  11. A spirometric journey following lung transplantation

    Science.gov (United States)

    Fuller, Jeremy; Paraskeva, Miranda; Thompson, Bruce; Snell, Greg; Westall, Glen

    2014-01-01

    Spirometry is regarded as the primary tool for the evaluation of lung function in lung transplant (LTx) recipients. Spirometry is crucial in detecting the various phenotypes of chronic lung allograft dysfunction (CLAD), including restrictive allograft syndrome (RAS) and bronchiolitis obliterans syndrome (BOS) – note that these phenotypes potentially have different etiologies and therapies. Following LTx for idiopathic pulmonary fibrosis, a 60-year-old male recipient’s lung function began to gradually improve, peaking at 5 months post-LTx. Subsequently, with increasing impairment of graft function, the diagnosis of BOS was made. A second LTx was performed and lung function subsequently began to increase again. Unfortunately, another year on, lung function deteriorated again – this time due to the development of RAS, antibody-mediated rejection was implicated as the possible underlying cause. This case report highlights the importance of spirometry in assessing the patterns of CLAD following LTx. PMID:25473588

  12. IgG4-RELATED DISEASE. CLINICAL NOTES

    Directory of Open Access Journals (Sweden)

    Vladimir Ivanovich Vasilyev

    2013-01-01

    Full Text Available IgG4-related diseases are a new nosological entity that encompasses a few previously known diseases. IgG4-related systemic disease is diagnosed if two or more affected organs are detected. This group of diseases has two similar signs: serological (elevated serum IgG4 subclass concentrations and histological (organ and tissue infiltration from plasmo-cytes secreting IgG4, and eosinophils, and the development of fibrosclerosis and phlebitis obliterans. The paper describes two cases. In one case, a multisystemic disease was observed virtually at its onset whereas in the other this lesion was diagnosed several years after the natural course of the disease.

  13. Adult diagnosis of Swyer-James-MacLeod syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Gouveia Paulo

    2011-01-01

    Full Text Available Abstract Introduction Swyer-James-MacLeod syndrome or unilateral hyperlucent lung syndrome is a rare entity associated with postinfectious bronchiolitis obliterans occurring in childhood. It is characterized by hypoplasia and/or agenesis of the pulmonary arteries resulting in pulmonary parenchyma hypoperfusion. Case presentation Here we report the case of a 53-year-old Caucasian woman with Swyer-James-MacLeod syndrome found in the differential diagnosis workup for a new onset of heart failure, secondary to pulmonary arterial hypertension complicated by a patent ductus arteriosus. Conclusion Typically, this disorder is diagnosed in childhood after evaluation for recurrent respiratory infections, but sometimes an indolent course means diagnosis is not made until adulthood.

  14. Beyond pneumonoconiosis: Recently described occupational interstitial lung diseases

    Directory of Open Access Journals (Sweden)

    Evangelia Nena

    2010-01-01

    Full Text Available SUMMARY. Recent technological innovations have resulted in the introduction of new substances in different manufacturing procedures. Unfortunately, lack of knowledge of the adverse effects of some novel substances has led to the development of interstitial lung disease (ILD among exposed workers. Exposure to diacetyl can cause bronchiolitis obliterans (“popcorn lung”, while exposure to nylon flock, Acramin-FWN, indium-tin oxide, biomass fuels or nanoparticles is associated with ILD. In addition, hypersensitivity pneumonitis can occur after exposure to additives in animal feed. Finally, new applications of substances already known to be hazardous can result in the occurrence of ILD in exposed workers. Pneumon 2010, 23(3:293-300.

  15. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.

    Science.gov (United States)

    Johnston, Y. E.; Duray, P. H.; Steere, A. C.; Kashgarian, M.; Buza, J.; Malawista, S. E.; Askenase, P. W.

    1985-01-01

    In 17 patients with Lyme disease, synovial specimens, obtained by synovectomy or needle biopsy, showed nonspecific villous hypertrophy, synovial cell hyperplasia, prominent microvasculature, lymphoplasmacellular infiltration, and sometimes lymphoid follicles. The larger surgically obtained specimens also showed striking deposition of fibrin in synovial stroma and a form of endarteritis obliterans. In 2 patients, spirochetes were seen in and around blood vessels by the Dieterle silver stain. Compared with 55 cases of other synovial disease, obliterative microvascular lesions were seen only in Lyme synovia, but marked stromal deposition of fibrin seemed nonspecific. These findings imply that the Lyme spirochete may survive for years in affected synovium and may be directly responsible for the microvascular injury. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 PMID:3966535

  16. Primary extranodal non-Hodgkin's lymphoma of the lung presenting with bilateral, patchy infiltrates dramatically improving after corticosteroid therapy.

    Science.gov (United States)

    Boon, E S; Graal, M B; van Noord, J A

    1993-10-01

    A 63-year-old man was admitted to the hospital with fever and bilateral, peripheral infiltrates. Infectious disease and malignancy seemed to be excluded by fiberoptic diagnostic procedures. Subsequently, respiratory insufficiency developed, making open lung biopsy impossible. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was strongly considered and treatment with corticosteroids was started; this led to dramatic clinical and radiologic improvement for a short time. Eventually, an open lung biopsy specimen disclosed primary extranodal non-Hodgkin's lymphoma of T-cell origin, immunoblastic, of high-grade malignancy according to the Kiel classification. After the first course of chemotherapy, total respiratory insufficiency developed and the patient died. This case is unique in a patient without AIDS.

  17. Acute viral bronchiolitis and its sequelae in developing countries.

    Science.gov (United States)

    Fischer, Gilberto Bueno; Teper, Alejandro; Colom, Alejandro J

    2002-12-01

    Acute viral bronchiolitis (AVB) is a common disease found throughout the world. Various aspects of it are being studied: its epidemiology, diagnosis, prognosis and treatment. Most of these studies are being conducted in developed countries, with only a few taking place in developing countries. Risk factors such as poor nutrition, an adverse environment and early weaning should be studied where these features are common. Treatment aspects such as cost-effectiveness in low income settings need further study. Use of ribavirin and respiratory syncytial virus (RSV)-immunoglobulin are good examples. Post-bronchiolitic sequelae also need to be studied in low income countries. There is evidence that bronchiolitis obliterans is unusually frequent in some Latin-American countries such as Argentina and Brazil. It will be helpful to undertake combined studies in countries with the same socio-economics, investigating the preventive and management aspects of AVB and its sequelae to reduce the morbidity and mortality.

  18. Swyer-James-Macleod Syndrome Presenting with Pulmonary Hypertension

    Directory of Open Access Journals (Sweden)

    Sh Hajsadeghi

    2010-09-01

    Full Text Available Swyer–James–MacLeod Syndrome is a rare condition as a result of childhood pulmonary infection, especially bronchiolitis obliterans or viral bronchiolitis/pneumonia. It appears as increased radiolucency on chest Xray, in the absence of obstructing lesions and can be confused for other thoracic disease processes such as a large pulmonary emboli or congenital bronchial and/or pulmonary vasculature malformations. We introduce a 46-year-old male patient presented with symptoms and signs of pulmonary hypertension which was initially misdiagnosed as chronic pulmonary emboli. This case highlights the possibility of pulmonary hypertension to be one of the cardinal manifestations of this syndrome, and outlines the significance of application of computedtomography in confirming the diagnosis of SJMS and in eliminating other diseases.

  19. Computed tomography findings of postoperative complications in lung transplantation; Achados tomograficos nas complicacoes pos-operatorias do transplante pulmonar

    Energy Technology Data Exchange (ETDEWEB)

    Hochhegger, Bruno; Irion, Klaus Loureiro; Marchiori, Edson; Bello, Rodrigo; Moreira, Jose; Camargo, Jose Jesus [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Postgraduate Program in Respiratory Sciences; Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Postgraduate Program in Radiological Sciences], e-mail: brunorgs@mail.ufsm.br

    2009-03-15

    Due to the increasing number and improved survival of lung transplant recipients, radiologists should be aware of the imaging features of the postoperative complications that can occur in such patients. The early treatment of complications is important for the long-term survival of lung transplant recipients. Frequently, HRCT plays a central role in the investigation of such complications. Early recognition of the signs of complications allows treatment to be initiated earlier, which improves survival. The aim of this pictorial review was to demonstrate the CT scan appearance of pulmonary complications such as reperfusion edema, acute rejection, infection, pulmonary thromboembolism, chronic rejection, bronchiolitis obliterans syndrome, cryptogenic organizing pneumonia, post transplant lymphoproliferative disorder, bronchial dehiscence and bronchial stenosis. (author)

  20. High-resolution computed tomography findings in pulmonary complications after bone marrow transplantation: iconographic essay; Tomografia computadorizada de alta resolucao nas complicacoes pulmonares pos-transplante de medula ossea: ensaio iconografico

    Energy Technology Data Exchange (ETDEWEB)

    Gasparetto, Emerson L.; Ono, Sergio E.; Souza, Carolina A. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Radiologia Medica e Diagnostico por Imagem]. E-mail: gasparetto@hotmail.com; Escuissato, Dante L. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina. Disciplina de Radiologia Medica; Rocha, Gabriela de Melo; Inoue, Cezar; Falavigna, Joao M. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina; Marchiori, Edson [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Universidade Federal, Rio de Janeiro (UFRJ), RJ (Brazil). Curso de Pos-graduacao em Radiologia

    2005-12-01

    Bone marrow transplantation has been the treatment of choice for many hematologic diseases. However, pulmonary complications, which may occur in up to 60% of the patients, are the main cause of treatment failure and may be divided in three phases according to the patient's immunity. In the first phase, up to 30 days after the procedure, there is a predominance of non-infectious complications and fungal pneumonia. Viral infections, mainly by cytomegalovirus, are common in the second phase (up to 100 days after bone marrow transplantation). Finally, in the late phase after bone marrow transplantation, non-infectious complications as bronchiolitis obliterans organizing pneumonia and graft-versus-host disease are most commonly seen. The authors present a pictorial essay of the high-resolution computed tomography findings in patients with pulmonary complications after bone marrow transplantation. (author)

  1. Belatacept for Maintenance Immunosuppression in Lung Transplantation

    Directory of Open Access Journals (Sweden)

    Christine Hui PharmD

    2014-06-01

    Full Text Available Belatacept is a novel immunosuppressant that blocks a T-cell costimulation pathway and is approved for use in adult kidney transplant recipients. Its safety and efficacy have not been established after lung transplantation. We present a case of a lung transplant recipient treated with belatacept. A 56-year-old man underwent bilateral lung retransplantation for bronchiolitis obliterans syndrome (BOS. In the third year posttransplant, he developed hemolytic uremic syndrome (HUS attributed to tacrolimus. Tacrolimus was changed to sirolimus. One month later, he presented with worsening renal function and HUS attributed to sirolimus. Plasmapheresis and steroid pulse were initiated with clinical improvement, and sirolimus was switched to belatacept. He experienced no episodes of cellular rejection but developed recurrent BOS. Complications during treatment included anemia and recurrent pneumonias. The safety and efficacy of belatacept in lung transplantation remains unclear; further studies are needed.

  2. [Interpretation and consideration of the Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities management of asymptomatic disease and claudication].

    Science.gov (United States)

    Shen, Chenyang; Li, Weihao

    2016-02-01

    Atherosclerotic occlusive disease of the lower extremities (ASO-LE) has the third highest rate among systematic atherosclerosis obliterans, ranking after coronary heart disease and stoke, and the disease burden of ASO-LE has been continuously increasing. Invasive revascularizations, which is presented by endovascular therapy technique, has undergone a dramatic development in the past couples of decades. However, controversy concerned about the surgical management and operative indications has heated up in the meanwhile. Thus Society for Vascular Surgery (SVS) published the practice guidelines for ASO-LE with asymptomatic disease and claudication in March, 2015. At the first time the guideline definitely opposed the aggressive invasive revascularization for ASO-LE patients with asymptomatic disease or claudication under satisfied tolerance. Instead, it posed the extreme emphasis on the pharmacotherapy with risk reduction of atherosclerosis at the core and the exercise therapy with supervised or home-based exercise program at the core for ASO-LE patients with asymptomatic disease and claudication.

  3. Cryptogenic Organising Pneumonia As The Initial Presenting Manifestation of SLE

    Directory of Open Access Journals (Sweden)

    Neena Mampilly

    2015-07-01

    Full Text Available Cryptogenic Organising Pneumonia (COP, also called idiopathic Bronchiolitis Obliterans Organising Pneumonia( BOOP, is a distinct entity among the idiopathic interstitial pneumonias defined histopathologically by intraalveolar buds of granulation tissue. The etiology includes idiopathic, infectious, drug induced radiation induced and connective tissue diseases. Organising pneumonia occurs particularly in patients with dermatomyositis-polymyositis where it may be the presenting manifestation, and rarely in SLE, rheumatoid arthritis, scleroderma and other connective tissue diseases. We describe a 30 yr old lady who initially presented with respiratory symptoms, not responding to antibiotics. She was subsequently diagnosed as SLE and HRCT thorax showed consolidation involving both lung fields. A percutaneous lung biopsy revealed features of Cryptogenic Organising Pneumonia.

  4. Steroids and/or Cytotoxic Agents Should Be Used Early in the Management of Patients with IPF -- The Pro Argument

    Directory of Open Access Journals (Sweden)

    Sat Sharma

    2004-01-01

    Full Text Available Idiopathic interstitial pneumonias comprise a heterogenous group of acute and chronic respiratory conditions. Katzenstein and Myers (1 classified these disorders according to several pathologically distinct categories: usual interstitial pneumonitis (UIP, desquamative interstitial pneumonitis ? respiratory bronchiolitis interstitial lung disease, acute interstitial pneumonitis, nonspecific interstitial pneumonitis and cryptogenic organizing pneumonitis or bronchiolitis obliterans organizing pneumonia (1. These disorders present with similar clinical features of shortness of breath, diffuse pulmonary infiltrates on chest radiograph, and histologically, a varying combination of inflammation and fibrosis. However, the natural history and response to therapy differs substantially, as some categories have more favourable prognoses than others (2. Idiopathic pulmonary fibrosis (IPF or fibrosing alveolitis is the clinical terminology for a specific interstitial pneumonia for which the pathological process is UIP. A disorder of unknown etiology, IPF is the most common and most lethal of all interstitial pneumonias.

  5. [Gastro-esophageal reflux and chronic respiratory diseases].

    Science.gov (United States)

    Dirou, S; Germaud, P; Bruley des Varannes, S; Magnan, A; Blanc, F-X

    2015-12-01

    Gastroesophageal reflux disease (GERD) frequently occurs in association with chronic respiratory diseases although the casual link is not always clear. Several pathophysiological and experimental factors are considered to support a role for GERD in respiratory disease. Conversely, respiratory diseases and bronchodilator treatment can themselves exacerbate GERD. When cough or severe asthma is being investigated, GERD does not need to be systematically looked for and a therapeutic test with proton pump inhibitors is not always recommended. pH impedance monitoring is now the reference diagnostic tool to detect non acid reflux, a form of reflux for which proton pump inhibitor treatment is ineffective. Recent data have shown a potential role of GERD in idiopathic pulmonary fibrosis and bronchiolitis obliterans following lung transplantation, leading to discussions about the place of surgery in this context. However, studies using pH impedance monitoring are still needed to better understand and manage the association between GERD and chronic respiratory diseases.

  6. Interstitial inflammatory lesions of the pulmonary allograft: a retrospective analysis of 2697 transbronchial biopsies

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.

    2008-01-01

    of 2697 biopsies were evaluated corresponding to a mean of 6+/-2 (median 8) completed schedules per patient. Diffuse alveolar damage (DAD) was the second most common histological finding within the first 2 weeks after transplantation. The peak prevalence of bronchiolitis obliterans organizing pneumonia......, incidence and possible associations between commonly identified inflammatory and fibrotic lesions in the pulmonary allograft. METHODS: Retrospective chart review of all transbronchial biopsies performed within the first 2 years of 299 lung-transplanted patients in the period 1996 to 2006. RESULTS: A total.......0001, respectively). Acute cellular rejection was not associated with DAD, and patients with lymphocytic bronchiolitis were not more likely to demonstrate features of organizing pneumonia (DAD or BOOP). CONCLUSIONS: Histologic findings of ACR, lymphocytic bronchiolitis, BOOP, and interstitial pneumonitis were...

  7. Penis cancer: a case report

    Directory of Open Access Journals (Sweden)

    Gregorio Sampalmieri

    2014-06-01

    Full Text Available Penis cancer appears as a small lesion that extends gradually to affect the whole of the glans and the shaft of the penis. Its peak incidence is in men aged 40 to 70 years. The most frequent malignant penis tumour is squamous cell carcinoma, which occurrence is probably favoured by smegma accumulation, HPV16 and 18 infection, smoke, and balanitis xerotica obliterans. Here we discuss the case of a 74-year-old man with sovrapubic pain and swelling. Physical examination reveals swollen glans with purulent secretions and oedema. The final diagnosis of squamous cell carcinoma is established by means of RMN and biopsy. Partial penectomy surgery follows. Histopathological examination shows poorly differentiated endophytic infiltrative growth. The tumour infiltrates corpus spongiosum, corpora cavernosa, and urethra. The proximal uretheral stump is free from infiltration (pT3.http://dx.doi.org/10.7175/cmi.v8i2.906 

  8. An international ISHLT/ATS/ERS clinical practice guideline:

    DEFF Research Database (Denmark)

    Meyer, Keith C; Raghu, Ganesh; Verleden, Geert M

    2014-01-01

    Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that is associated with poor survival. The International Society for Heart and Lung Transplantation, American Thoracic Society, and European Respiratory Society convened a committee of international experts...... to March, 2013. The expert committee discussed the available research evidence upon which the updated definition of BOS, identified risk factors and recommendations are based. The committee followed the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) approach to develop specific......, and several risk factors have been identified that have a significant association with the onset of BOS. Currently available therapies have not been proven to result in significant benefit in the prevention or treatment of BOS. Adequately designed and executed randomised controlled trials that properly...

  9. Management of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid in Adults

    Science.gov (United States)

    Stark, Timothy W; Lacy, John M; Preston, David M

    2016-01-01

    A 74-year-old man presented for evaluation after discovery of a left bladder-wall tumor. He underwent transurethral resection of bladder tumor (TURBT) operation for treatment of low-grade, Ta urothelial cancer of the bladder. The patient developed recurrent disease and returned to the operating room for repeat TURBT, circumcision, and administration of intravesical mitomycin C. The patient developed balanitis xerotica obliterans 4 years post-circumcision, requiring self-dilation with a catheter. He subsequently developed 3 consecutive episodes of left-sided pyelonephritis. Further investigation with voiding cystourethrogram (VCUG) revealed Grade 3, left-sided vesicoureteral reflux (VUR). Due to existing comorbidities, the patient elected treatment with endoscopic dextranomer/hyaluronic acid injection. A post-operative VCUG demonstrated complete resolution of left-sided VUR. This patient has remained symptom free for 8 months post-injection, with no episodes of pyelonephritis. PMID:27162514

  10. [Comparative assessment of antiaggregant efficacy of acetylsalicylic acid and clopidogrel in peripheral atherosclerosis].

    Science.gov (United States)

    Kuznetsov, M R; Sergeeva, N A; Koshkin, V M; Boldin, B V; Rodionov, S V; Virganskiĭ, A O; Kosykh, I V; Lisenkov, O P; Kuznetsova, V F

    2014-01-01

    Presented in the article are the results of studying antiaggregate activity of acetylsalicylic acid and clopidogrel in a total of 36 patients suffering from various-severity chronic arterial insufficiency of lower limbs on the background of atherosclerosis obliterans. The study was conducted prior to treatment for correct selection of a particular antiplatelet agent. The obtained results showed that clopidogrel was not always more efficient than acetylsalicylic acid, since there is individual sensitivity of each patients to a particular antiplatelet agent. Therefore, an individual approach is necessary to conservative therapy of arterial insufficiency of lower limbs. For some patients it is preferable to administer clopidogrel, for others - acetylsalicylic acid. In a series of cases combined treatment is justified, while some patients having low sensitivity to both acetylsalicylic acid and clopidogrel require careful selection of alternative agents influencing other thrombocyte receptors.

  11. Buerger’s disease: providing integrated care

    Directory of Open Access Journals (Sweden)

    Klein-Weigel P

    2016-10-01

    Full Text Available Peter Klein-Weigel,1 Theresa Sophie Volz,1 Leonora Zange,2 Jutta Richter,3 1Clinic of Angiology, 2Clinic of Cardiology and Nephrology, HELIOS Klinikum Berlin-Buch, Berlin, 3Medical Faculty, Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany Abstract: Buerger’s disease, also known as thromboangiitis obliterans (TAO, is a segmental inflammatory disease affecting small- and medium-sized vessels, which is strongly associated with tobacco use. Although the etiology is still unknown, recent studies suggest an immunopathogenesis. Diagnosis is based on clinical and angiomorphologic criteria, including age, history of smoking, clinical presentation with distal extremity ischemia, and the absence of other risk factors for atherosclerosis, autoimmune disease, hypercoagulable states, or embolic disease. Until now, no causative therapy exists for TAO. The most important therapeutic intervention is smoking cessations and intravenous prostanoid infusions (iloprost. Furthermore, effective analgesia is crucial for the treatment of ischemic and neuropathic pain and might be expanded by spinal cord stimulation. Revascularization procedures do not play a major role in the treatment of TAO due to the distal localization of arterial occlusion. More recently, immunoadsorption has been introduced eliminating vasoconstrictive G-protein-coupled receptor and other autoantibodies. Cell-based therapies and treatment with bosentan were also advocated. Finally, a consequent prevention and treatment of wounds and infections are essential for the prevention of amputations. To achieve better clinical results, integrated care in multidisciplinary and trans-sectoral teams with emphasis on smoking cessation, pain control, wound management, and social care by professionals, social workers, and family members is necessary. Keywords: Winiwater-Buerger's disease, Winiwarter–Buerger, thromboangiitis

  12. [Recanalization of the peripheral arteries by laser thermal balloon angioplasty. 2 years of clinical experience].

    Science.gov (United States)

    Riambau Alonso, V; Masotti Centol, M; Latorre Vilallonga, J; Viver Manresa, E; Crexells Figueres, C; Oriol Palou, A

    1991-01-01

    Laser angioplasty represents an attractive alternative to overcome the limitations of balloon angioplasty. We describe our results with laser thermal balloon angioplasty (LTBA) in the treatment of atherosclerosis obliterans in the lower limbs after two years clinical follow up. We also analyse the influence of lesion characteristics on immediate results. Thirty seven patients (34 men), whose mean age was 58 +/- 9 years, were included in this study. Occlusive arterial disease (Fontaine stage II-IV), with 39 significant haemodynamic arterial lesions were present in all of them. Ankle/brachial Doppler index was O,51 +/- 0,17. Eighteen lesions were located in the iliac area (13 stenoses 2,3 +/- 1 cm of length and 5 occlusions 4,2 +/- 3 cm) and 21 lesions in femoro-popliteal area (5 stenoses 2,6 +/- 2 cm and 16 occlusions 5,7 +/- 3 cm). A percutaneous procedure was used in 38 cases and only in one case a femoral dissection was necessary. The laser source was argon in 26 cases and Nd-YAG in 13. The overall immediate angiographic and clinical success was 85% (89% in iliac lesions and 81% in femoropopliteal lesions; 100% in stenoses and 70% in occlusions). The presence of occlusion (p less than 0,01) and/or calcium (p less than O,05) influenced negatively the immediate results. No major complications were observed. Seven (17%) minor complications occurred, but no emergency surgery was necessary. The ankle/brachial Doppler index after treatment was 0,82 +/- 0,21. Cumulative clinical patency was 91% for successfully treated patients after two years follow up. We conclude that LTBA represents an effective and less aggressive way to treat atherosclerosis obliterans.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Screening with spirometry is a useful predictor of later development of noninfectious pulmonary syndromes in patients undergoing allogeneic stem cell transplantation.

    Science.gov (United States)

    Thompson, Philip A; Lim, Andrew; Panek-Hudson, Yvonne; Tacey, Mark; Hijazi, Ramzi; Ng, Ashley P; Szer, Jeff; Ritchie, David; Bajel, Ashish

    2014-06-01

    Noninfectious pulmonary syndromes (NIPS) frequently complicate allogeneic stem cell transplantation (allo-SCT). The most common and serious is the bronchiolitis obliterans syndrome, characterized by irreversible fixed airflow obstruction, impaired quality of life, and a high mortality. Treatment for established symptomatic disease is relatively ineffective. We therefore sought to identify potential predictive factors for development of NIPS, which may identify patients at risk in whom earlier intervention may be of benefit. Spirometry and diffusing capacity for carbon monoxide were performed before allo-SCT, day 100, and 1 year after allo-SCT. We retrospectively analyzed spirometry in consecutive patients having allo-SCT from 2004 to 2010, along with computed tomography and bronchoalveolar lavage results to identify cases of NIPS. Cases of bronchiolitis obliterans syndrome were defined as per current National Institutes of Health consensus guidelines. Spirometry results and baseline variables were compared between patients with and without NIPS to identify early predictors and risk factors for NIPS. Of 235 assessable patients, 23 (9.8%) developed NIPS. Median time of onset was day 367 (interquartile range [IQR], 144 to 544 days). Changes in forced expiratory volume in 1 second (ΔFEV1.0) was the best predictor of later NIPS development. Median ΔFEV1.0 from pretransplant to day 100 in patients later developing NIPS was -12% (IQR, -25% to -1%) versus -1% (IQR, -7% to +6%) in unaffected patients, P = .002. From pretransplant to 1 year, ΔFEV1.0 was -19% (IQR, -37% to -6%) versus -3% (IQR, -10% to +4%) in patients later developing NIPS and unaffected patients, respectively, P Spirometry is a potentially useful screening test for identification of presymptomatic NIPS. We recommend 3-monthly spirometry surveillance for up to 2 years post-transplant. Our findings require prospective validation to identify patients in whom earlier intervention may potentially modify the

  14. Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear.

    Directory of Open Access Journals (Sweden)

    Giselle Chamberlain

    Full Text Available Mesenchymal stem cells (MSCs have anti-inflammatory and immunosuppressive properties and may be useful in the therapy of diseases such as arteriosclerosis. MSCs have some ability to traffic into inflamed tissues, however to exploit this therapeutically their migratory mechanisms need to be elucidated. This study examines the interaction of murine MSCs (mMSCs with, and their migration across, murine aortic endothelial cells (MAECs, and the effects of chemokines and shear stress. The interaction of mMSCs with MAECs was examined under physiological flow conditions. mMSCs showed lack of interaction with MAECs under continuous flow. However, when the flow was stopped (for 10 min and then started, mMSCs adhered and crawled on the endothelial surface, extending fine microvillous processes (filopodia. They then spread extending pseudopodia in multiple directions. CXCL9 significantly enhanced the percentage of mMSCs adhering, crawling and spreading and shear forces markedly stimulated crawling and spreading. CXCL9, CXCL16, CCL20 and CCL25 significantly enhanced transendothelial migration across MAECs. The transmigrated mMSCs had down-regulated receptors CXCR3, CXCR6, CCR6 and CCR9. This study furthers the knowledge of MSC transendothelial migration and the effects of chemokines and shear stress which is of relevance to inflammatory diseases such as arteriosclerosis.

  15. Lower extremity vasculitis in giant cell arteritis: important differential diagnosis in patients with lower limb claudication.

    Science.gov (United States)

    Sigl, Martin; Hsu, Eric; Scheffel, Hans; Haneder, Stefan; Rümenapf, Gerhard; Amendt, Klaus

    2014-09-01

    Most patients with peripheral arterial disease suffer from arteriosclerosis, the prevalence of which increases with age. In some of these patients, however, the ischemic symptoms are not caused by stenotic arteriosclerosis, but by large vessel giant cell arteritis (LV-GCA), a disease also predominantly affecting patients of the older generation. Identifying large vessel vasculitis is a challenge for all physicians caring for patients with peripheral artery disease. The results of invasive treatment such as bypass surgery and angioplasty of inflammatory vascular lesions differ fundamentally from those of patients with atherosclerosis. Duplex ultrasound is a widely available diagnostic method for examining patients with lower limb claudication and pathological ankle-/toe- brachial index or pulse volume recording with or without exercise. Knowledge of characteristic sonographic findings suspicious about large vessel vasculitis is essential for a differential diagnosis of vasculitis versus atherosclerosis. In addition to clinical and laboratory findings, further imaging techniques, e.g. contrast-enhanced computed tomography, magnetic resonance imaging or a combination of positron emission tomography and computed tomography (PET-CT) can provide information on further vessel involvement and inflammatory activity. The present study focuses on diagnostic imaging of LV-GCA in patients presenting with claudication, illustrated by a series of cases.

  16. Soft Tissue Mineralization in Captive 2-Toed Sloths.

    Science.gov (United States)

    Han, S; Garner, M M

    2016-05-01

    Soft tissue mineralization was diagnosed in 19 captive 2-toed sloths (Choloepus didactylusandCholoepus hoffmanni) ranging from 2 months to 41 years of age. Gross mineralization was evident at necropsy in 6 of 19 sloths and was prominent in the aorta and arteries. Histologically, 11 sloths had arterial mineralization, including mural osseous and chondroid metaplasia and smooth muscle hyperplasia consistent with arteriosclerosis. Visceral mineralization most commonly involved the gastric mucosa (17 sloths), kidneys (17 sloths), and lungs (8 sloths). Eleven sloths ranging in age from 5 to 41 years old had moderate to severe renal disease, which may be an important underlying cause of soft tissue mineralization in adult sloths. However, 5 sloths (juveniles and adults) had severe soft tissue mineralization with histologically normal kidneys or only mild interstitial inflammation or fibrosis, suggesting other causes of calcium and phosphorus imbalance. Degenerative cardiac disease was a common finding in 10 sloths with vascular mineralization and varied from mild to severe with fibrosis and acute noninflammatory myocardial necrosis. Although the prevalence of cardiac disease in adult sloths has not been documented, disease may be exacerbated by hypertension from degenerative arteriosclerosis as noted in this study group. Although renal disease likely contributed substantially to mineralization of tissues in most sloths in this study, nutritional causes of soft tissue mineralization-such as imbalances in dietary vitamin D or calcium and phosphorus-may be an important contributing factor.

  17. Hyperuricemia and carotid artery dilatation among young adults without metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Eswar Krishnan

    2012-10-01

    Full Text Available It is not known if hyperuricemia is associated with early vascular changes signifying arteriosclerosis. We performed a cross sectional study of 163 young adults without metabolic syndrome in Allegheny County, PA, USA. Doppler ultrasound was used to measure two metrics of early arteriosclerosis: carotid artery dimensions and aortic pulse wave velocity. Individuals in the highest quartiles of serum uric acid (>6.2 mg/dL for men and >4.6 for women were more likely to be of younger age, and to possess greater measures of adiposity and an adverse cardiovascular risk profile. Higher serum uric acid concentration was associated with larger luminal and adventitial diameters as well as changes in diameters between the phases of the cardiac cycle (P<0.001 but not with carotid intima media thickness, pulse wave velocity, or pressure strain modulus. In multivariable linear regression models where the effects of age, ethnicity, serum creatinine, systolic blood pressure, current alcohol use, body mass index and smoking status were accounted for, the highest quartile of serum uric acid was associated with greater luminal and adventitial diameters and change in luminal diameter between the phases of cardiac cycle (P<0.05, but not with pulse wave velocity, pressure strain modulus or carotid intima media thickness. We can conclude that hyperuricemia is associated with larger carotid artery diameters signifying an early adaptive response to vascular stress. This has implications on the observed link between hyperuricemia and hypertension.

  18. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats

    Directory of Open Access Journals (Sweden)

    Yuko Inami

    2014-01-01

    Full Text Available Aim. Chronic kidney disease (CKD represents endothelial dysfunction. Monocyte adhesion is recognized as the initial step of arteriosclerosis. Indoxyl sulfate (IS is considered to be a risk factor for arteriosclerosis in CKD. Oral adsorbent AST-120 retards deterioration of renal function, reducing accumulation of IS. In the present study, we determined the monocyte adhesion in the adenine-induced uremic rats in vivo and effects of AST-120 on the adhesion molecules. Methods. Twenty-four rats were divided into control, control+AST-120, adenine, and adenine+AST-120 groups. The number of monocytes adherent to the endothelium of thoracic aorta by imaging the entire endothelial surface and the mRNA expressions of adhesion and atherosclerosis-related molecules were examined on day 49. The mRNA expressions of ICAM-1 and VCAM-1 in human umbilical vein endothelial cells were also examined. Results. Adenine increased the number of adherent monocytes, and AST-120 suppressed the increase. The monocyte adhesion was related to serum creatinine and IS in sera. Overexpression of VCAM-1 and TGF-β1 mRNA in the arterial walls was observed in uremic rats. IS induced increase of the ICAM-1 and VCAM-1 mRNA expressions in vitro. Conclusion. It appears that uremic condition introduces the monocyte adhesion to arterial wall and AST-120 might inhibit increasing of the monocyte adherence with CKD progression.

  19. Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

    Directory of Open Access Journals (Sweden)

    Karla Lais Pêgas

    2014-04-01

    Full Text Available Introduction: Pre-implantation kidney biopsy is a decision-making tool when considering the use of grafts from deceased donors with expanded criteria, implanting one or two kidneys and comparing this to post-transplantation biopsies. The role of histopathological alterations in kidney compartments as a prognostic factor in graft survival and function has had conflicting results. Objective: This study evaluated the prevalence of chronic alterations in pre-implant biopsies of kidney grafts and the association of findings with graft function and survival in one year post-transplant. Methods: 110 biopsies were analyzed between 2006 and 2009 at Santa Casa de Porto Alegre, including live donors, ideal deceased donors and those with expanded criteria. The score was computed according to criteria suggested by Remuzzi. The glomerular filtration rate (GFR was calculated using the abbreviated MDRD formula. Results: No statistical difference was found in the survival of donors stratified according to Remuzzi criteria. The GFR was significantly associated with the total scores in the groups with mild and moderate alterations, and in the kidney compartments alone, by univariate analysis. The multivariate model found an association with the presence of arteriosclerosis, glomerulosclerosis, acute rejection and delayed graft function. Conclusion: Pre-transplant chronic kidney alterations did not influence the post-transplantation one-year graft survival, but arteriosclerosis and glomerulosclerosis is predictive of a worse GFR. Delayed graft function and acute rejection are independent prognostic factors.

  20. Plaque of atherosclerosis in aorta: review on atherogenesis, formation of plaque, clinical significance, methods of imaging and treatment; Placa de aterosclerose em aorta: revisao sobre aterogenese, formacao de placa, significado clinco, metodos de imagens e tratamento

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, Rogerio Gomes; Nunes, Colandy G. de Oliveira; Rassi Junior, Luis; Melato, Luciano Henrique; Turco, Fabio de Paula; Borges, Moises Marcos, E-mail: rogerinhofurtado@gmail.com [Centro de Diagnostico por Imagem (CDI), Goiania, GO (Brazil); Sara, Leonardo [Instituto do Coracao (InCor/FM/USP), Sao Paulo, SP (Brazil)

    2009-04-15

    There is a certain consensus in the literature that the earliest stage of atherogenesis is characterized by the accumulation of spongy cells in the region of the intimal artery. Risk factors such as arterial hypertension, smoking, diabetes mellitus, hypercholesterolemia, male gender and advanced age predispose a person to the formation of plaques in the coronaries and aorta. A greater number of acute coronary events as well as strokes have been observed in people with these risk factors. Strokes are the third cause of death in the USA, with about 40% of the cases being of cryptogenic origin. Since 1989 the atheroma plaques which develop in the thoracic aorta have been considered to be responsible for cerebral and peripheral strokes which were previously considered cryptogenic because imaging techniques such as electrocardiogram transesophageal, computerized tomogram, nuclear magnetic angio-resonance have visualized and characterized the lesions with plaques of arteriosclerosis in the thoracic aorta. The authors of this article made a systematic review in the PUBMED about arteriosclerosis in the aorta and its diagnostic methods. This review includes the physiopathology of the formation of atheroma to the aorta and its consequences, diagnostic methods such as echo transesophageal, computerized tomogram and angio resonance, as well as the advantages and disadvantages of each method of identification of the lesions. An analysis of the clinical significance of the size, form and location of the atheroma plaques in the thoracic aorta were made based on clinical studies, as well as their treatment with anticoagulants, antiplatelet and drugs to reduce cholesterol. (author)

  1. 超重和肥胖与动脉僵硬度的相关性研究%Association between overweight, obesity and arterial stiffness in community residents

    Institute of Scientific and Technical Information of China (English)

    黄晖明; 李森; 许浩

    2011-01-01

    Objective To evaluate the relationship between overweight,obesity and arterial stiffness in community residents.Methods A total of 4585 community-dwelling adults in Jiangsu province,China were surveyed with the method of stratified and cluster sampling from 2007 to 2009.Overweight and obesity were defined by body mass index (BMI) and arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV).Statistical analysis of arteriosclerosis included multivariate logistic regression testing among which BMI was viewed as continuous variable( 1 kg/m2 increasing to BMI)and categorical variables (underweight,normal,overweight and obesity) respectively.Odds ratio,population attributable risk percent and the optimal cut-off points for BMI to evaluate arteriosclerosis were analyzed using receiver operator characteristic (ROC) curve.Results ( 1 ) After age control,BMI of male or female were positively correlated with baPWV (r =0.213,P <0.01; r =0.186,P <0.01).baPWV and prevalence of arteriosclerosis were significantly higher in obese residents compared with normal body weight group ( all P < 0.01 ).(2)As a continuous variable,the odds ratio value of BMI on predicting arteriosclerosis was 1.146 (95%CI:1.117 - 1.175,P < 0.01 ) after adjusting of age,gender and hypertension.As categorical variables,the odds ratio value of BMI was 0.369(95% CI:0.141 -0.962,P <0.05) for underweight group,1.576 (95% CI:1.333 - 1.863 ) for overweight group and 2.087 ( 95% CI:1.615 - 2.698 ) for obesity group (all P <0.01 ).(3) The population attributable arteriosclerosis risk was 19.1% and 11.6%in overweight and obesity groups,respectively.The area under the ROC curve was 0.661 (95% CI:0.645 -0.678,P < 0.01 ) and the optimal cut-off point for BMI to evaluate arteriosclerosis was 24.25 kg/m2.Conclusions Overweight and obese residents faced higher risk for arteriosclerosis than normal population.Overweight and obesity are independent risk factors for

  2. Ophthalmic Examination Outcome of Disabled Persons in Shanghai%上海市残疾人眼科检查结果分析

    Institute of Scientific and Technical Information of China (English)

    王倩; 宗莲; 刘斐霞; 张悠然; 康琦; 唐瑞瑞; 白燕; 吕军; 陈刚

    2016-01-01

    目的:了解上海市残疾人的眼科检查情况,为残疾人眼病预防、治疗及健康指导提供依据。方法通过上海市残疾人联合会的“康复综合信息平台”,收集2011年1月—2014年8月上海市阳光康复中心和2013年1月—2014年6月上海市康复职业培训中心的残疾人眼科健康体检数据75336份(上海市阳光康复中心45084份,上海市康复职业培训中心30252份)。主要收集内容包括残疾人的基本人口学情况、残疾特征及眼科体检结果。比较并分析不同性别、年龄、疾病特征残疾人的眼科异常结果检出情况。结果共检出眼科异常结果145种,检出率排在前3位的分别为眼底动脉硬化(37.37%,28153/75336)、屈光不正(16.47%,12406/75336)、白内障(15.77%,11879/75336)。(1)不同性别残疾人的眼底动脉硬化、屈光不正、白内障、胬肉、玻璃体混浊、黄斑变性、视网膜病变、眼底病变检出率比较,差异有统计学意义(P 0.05)。(2)不同年龄残疾人的眼底动脉硬化、屈光不正、白内障、胬肉、玻璃体混浊、失明、黄斑变性、视网膜病变、斜视、眼底病变检出率比较,差异均有统计学意义(P 0. 05). (2)There were significant differences in the detection rate of fundus arteriosclerosis, ametroia ametropia,cataract,pterygium,vitreous opacity, blindness, macular degeneration, retinopathy, strabismus and fundus lesions among the disabled with different ages(P < 0. 05). (3)There were significant differences in the detection rate of fundus arteriosclerosis,ametropia,cataract,pterygium,vitreous opacity,blindness,macular degeneration,retinopathy, strabismus and fundus lesions among the disabled with different disability types( P < 0. 05). (4) There were significant differences in the detection rate of fundus arteriosclerosis,ametropia,cataract,pterygium,macular degeneration and strabismus among the disabled with

  3. 高龄老年人脉压差、血脂、血糖关系分析%Analysis of the Correlation between Pulse Pressure,Blood Lipid,Blood Sugar in the Elderly People

    Institute of Scientific and Technical Information of China (English)

    丁翊; 刘芳

    2013-01-01

    Objective:Removed the age factor, to probe into the correlation between blood pressure,blood lipid,blood sugar and arteriosclerosis in the elderly people. Methods:Analyzed the correlation between Pulse Pressure,Mean Arterial blood pressure and Diabetes mellitus,Hypertension in 279 examination of the elderly. analyzed the changes of blood glucose,blood lipid at the different levels of Pulse Pressure. In order to know the correlation between Pulse Pressure,Mean Arterial blood pressure and blood glucose,blood lipid, blood pressure. Results:There was a correlation between arteriosclerosis and arterial compliance in the elderly people and hyperglycemia,the disorder of lipid metabolism and high systolic blood pressure. Conclusions:Strengthened the blood glucose management and the treatment of dyslipidemia in patients with diabetes mellitus, strengthened the control of blood pressure in patients with essential hypertension, these measures had a positive effect on prevention and treatment of senile arteriosclerosis.%目的:探讨老年动脉硬化除去年龄因素以外与血压、血糖、血脂的关系。方法:体检的老年人279例,分析脉压、平均动脉压与糖尿病、高血压病的关系及不同脉压水平下血糖、血脂的变化,进一步了解脉压、平均动脉压与血糖、血脂、血压之间的关系。结果:高龄老年人动脉硬化、血管顺应性减低与血糖增高、血脂代谢紊乱、收缩压增高有关。结论:加强糖尿病患者的血糖管理及血脂紊乱的治疗、加强高血压病患者血压控制对老年动脉硬化的防治有积极作用。

  4. 视网膜动脉硬化与颈动脉内膜中层厚度相关性的分析%Analysis of retinal artery atherosclerosis and carotid artery intima-media thickness correlation

    Institute of Scientific and Technical Information of China (English)

    萨其热; 佟艳秋(通讯作者); 赵全良

    2014-01-01

    With the improvement of living standards of our people and changes in diet , atherosclerosis tends to increase , which is char-acterized by intimal involvement began , more performance for the eye retina arteriosclerosis .This paper analyzes the relationship and relat-ed factors between retinal arteriosclerosis with IMT .The results show that a growing number of retinal artery atherosclerosis with carotid in -timal thickening , IMT and retinal arteriosclerosis is a mutual influence , mutual causal relationship in diabetics .Carotid stenosis , especial-ly the internal carotid artery stenosis can directly affect the retinal blood supply .Therefore , early diagnosis helps to evaluate the situation whole body atherosclerosis .For coronary heart disease , hypertension , cerebrovascular accident and CRAO patients and high -risk groups play a good warning , delaying disease progression .%随着我国人民生活水平的提高和饮食习惯的改变,动脉硬化呈增高趋势,其特点是受累病变的内膜开始,眼部多表现为视网膜动脉硬化。本文对视网膜动脉硬化与IMT相关性及相关因素进行观察分析。结果表明,越来越多的视网膜动脉粥样硬化合并颈动脉内膜增厚,糖尿病患者IMT与视网膜动脉硬化是相互影响,互为因果的关系。颈动脉狭窄特别是颈内动脉狭窄可直接影响视网膜血供。因此,早期诊断有助于判定全身动脉硬化情况,对冠心病、高血压、脑血管意外以及CRAO等患者及高危人群起到良好的警示作用,延缓疾病的进展。

  5. 下肢动脉硬化闭塞症药物治疗及评价%The pharmacotherapy and evaluation of lower extremity atherosclerotic occlusive diseases

    Institute of Scientific and Technical Information of China (English)

    吴庆华

    2016-01-01

    下肢动脉硬化闭塞症作为动脉硬化性血管病的一种疾病,其发病率呈明显上升趋势。高血压、血脂异常、糖尿病、吸烟等心血管病危险因素水平的持续上升是导致我国居民动脉硬化闭塞性疾病发病率上升的主要原因。故防治动脉硬化闭塞性疾病应以控制危险因素为切入点,药物治疗具有关键性作用。应重视临床研究以制定相关指南,以此给予病人规范化的药物治疗包括抗血小板、降脂、控制血糖和血压,以延缓动脉硬化进展,改善下肢缺血症状,确保术后支架或移植物通畅率,降低心脑血管事件的发生,最终提高病人的存活率。%Lower extremity atherosclerotic occlusive diseases, as one of atherosclerotic occlusive diseases, the incidence of which has been significantly increased. The continuous rise of cardiovascular risk factors such as hypertension, dyslipidemia, diabetes mellitus, smoking and so on are the main causes of the prevalence of arteriosclerosis occlusive disease in China. Therefore, prevention and treatment of arteriosclerosis occlusive disease should be based on the control of risk factors. Pharmacotherapy has a key role. Surgeons should pay more attention to clinical research in order to formulate the guidelines, based on which patients could receive standardized drug treatment, including anti-platelet, lipid-lowering, regulating blood sugar and blood pressure.The purposes are to delay the progress of arteriosclerosis, to improve the ischemic symptoms of the lower limb, to ensure the stent or graft’s patency rate, to reduce the incidence of cardiovascular and cerebrovascular events, and ultimately to improve the survival rate of patients.

  6. Respiratory Care Guide on Acute Exacerbation of Bronchial Asthma%支气管哮喘急性发作期的呼吸指导与护理

    Institute of Scientific and Technical Information of China (English)

    袁静

    2011-01-01

    目的:探讨支气管哮喘急性发作期的呼吸指导和临床护理方法.方法:对照组所有患者均采用传统护理方法,包括严密观察病情、保持呼吸道畅通、心理护理和健康教育:研究组患者在此基础上,行加强性呼吸指导和呼吸训练护理.结果:研究组患者的护理临床总有效率100%明显高于对照组96.08%,数据经统计学比较具有显著差异(P<0.05).结论:有效的呼吸指导与洲练护理,对于减少临床不良症状、提高呼吸力具有良好的疗效.%Objective: To explore effect of promoting cerebral venous return on brain function and inflammatory factor of patients with acute arteriosclerosis cerebral infarction for the reference in clinical treatment.Methods: Forty patients with acute arteriosclerosis cerebral infarction were taken as Observation Group and healthy examined people as Control Group. Observation Group was treated with thrombolysis-based therapy promoting cerebral venous return. Please observe variations in sICAM-1, sVCAM-1 and hs-CR inflammatory markers of both groups before and after treatmentResults: After therapy promoting cerebral venous return, 28 cases' brain function took a turn for the better and 12 cases not. Logistic regression analysis showed hs-CRP activity wss an independent inflammatory marker of efficacy of clinical prognosis (P<0.05). Con elusion :It improved brain function of patients with acute arteriosclerosis cerebral infarction and changed the inflammatory factor by promoting cerebral venous return. Hereinto, hs-CRP activity gave a hint at cerebral infarction to a certain degree.

  7. Water hardness in relation to cadium accumulation and microscopic signs of cardiovascular disease in horses.

    Science.gov (United States)

    Elinder, C G; Jonsson, L; Sternström, T; Piscator, M; Linnman, L

    1980-01-01

    The hardness of drinking water (i.e., the sum of calcium and magnesium concentrations) has been related to cadmium concentration in kidney cortex and to microscopic signs of arteriosclerosis and focal myocardial fibrosis in 50 Swedish horses slaughtered for meat production. A significant negative correlation was found between water hardness and cadmium concentrations in kidney cortex. This indicates that horses living in soft water areas are more inclined to accumulate cadmium from the general environment. Microscopic changes in the aorta and myocardium were approximately 2 times as frequent in horses that drank soft water compared to horses that drank hard water. The differences were, however, not statistically significant. It is concluded that horses are well suited for studies of the "water factor".

  8. Study the active site of flavonoid applying radiation chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Wu Jilan; Sun Gang; Zhang Fugen; He Yongke; Li Jiuqiang [Department of Technical Physics, Peking Univ., Beijing (China)

    2000-03-01

    Flavonoid are a large and important class of naturally occurring, low molecular weight benzo-{gamma}-pyrone derivatives which are reported to have a myriad of biological activities, but the study on the active sites of flavonoids is still ambiguous. In this paper, rutin, quercetin and baicalin have been selected as model compounds. It is well known that rutin is used in inhibiting arteriosclerosis and baicalin is antibacterial and antiviral. They have similar basic structure, but their medicinal properties are so different, why? As most flavonoids contain carbonyl group, which can capture electron effectively, we predict that flavonoids can capture electron to form radical anion. The formation of anion radical may have influence on the mitochondrial electron transport chain. The difference in the ability of forming anion radical may cause the difference in their medicinal effects. (author)

  9. Occurrence of occlusive intimal changes in an expanded polytetrafluoroethylene graft.

    Science.gov (United States)

    Carson, S N; Hunter, G; French, S; Lord, P; Wong, H N

    1980-01-01

    A case report is presented demonstrating pathologic changes in the neointima that formed when a polytetrafluoroethylene (PTFE) graft was placed in a 35 year old white male with severe arteriosclerosis. Representative sections of the patient's artery and graft were taken which demonstrated considerable smooth muscle proliferation in both along with full wall healing in the latter. Partial oclusion of the total length of the PTFE graft by a process similar to that occurring in the patient's own arteriosclerotic arteries was found. The consistency and extent of the involvement (> 10 cm in length) would appear to preclude entities such as neointimal fibrous hyperplasia and may point to another consequence of intimal injury and full wall graft healing which may be an undesirable effect of arteriosclerotic metabolism in the human. It is conceivable that full wall graft healing in an arteriosclerotic individual may have untoward events that need to be further investigated as new graft materials are developed.

  10. Hutchinson–Gilford progeria syndrome with severe calcific aortic valve stenosis

    Science.gov (United States)

    Hanumanthappa, Natesh B; Madhusudan, Ganigara; Mahimarangaiah, Jayaranganath; Manjunath, Cholenahally N

    2011-01-01

    Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging syndrome that results from mutation in the Laminin A gene. This case report of a 12-year-old girl with HGPS is presented for the rarity of the syndrome and the classical clinical features that were observed in the patient. All patients with this condition should undergo early and periodic evaluation for cardiovascular diseases. However, the prognosis is poor and management is mainly conservative. There is no proven therapy available. Mortality in this uniformly fatal condition is primarily due to myocardial infarction, strokes or congestive cardiac failure between ages 7 and 21 years due to the rapidly progressive arteriosclerosis involving the large vessels. PMID:21976890

  11. Garlic: empiricism or science?

    Science.gov (United States)

    Aviello, Gabriella; Abenavoli, Ludovico; Borrelli, Francesca; Capasso, Raffaele; Izzo, Angelo Antonio; Lembo, Francesca; Romano, Barbara; Capasso, Francesco

    2009-12-01

    Garlic (Allium sativum L. fam. Alliaceae) is one of the best-researched, best-selling herbal remedies and is also commonly used as a food and a spice. Garlic constituents include enzymes (for example, alliinase) and sulfur-containing compounds, including alliin, and compounds produced enzymatically from alliin (for example, allicin). Traditionally, it has been employed to treat infections, wounds, diarrhea, rheumatism, heart disease, diabetes, and many other disorders. Experimentally, it has been shown to exert antilipidemic, antihypertensive, antineoplastic, antibacterial, immunostimulant and hypoglycemic actions. Clinically, garlic has been evaluated for a number of conditions, including hypertension, hypercholesterolemia, intermittent claudication, diabetes, rheumatoid arthritis, common cold, as an insect repellent, and for the prevention of arteriosclerosis and cancer. Systematic reviews are available for the possible antilipidemic, antihypertensive, antithrombotic and chemopreventive effects. However, the clinical evidence is far from compelling. Garlic appears to be generally safe although allergic reactions may occur.

  12. PATHOMORPHOLOGY OF ZERO BIOPSIES OF DONOR KIDNEYS

    Directory of Open Access Journals (Sweden)

    M. L. Arefjev

    2011-01-01

    Full Text Available There is well known fact that kidney transplants from Extended Criteria Donors may increase risk of De- layed Graft Function and Primary Non-Function of transplants. We have collected and tested 65 «zero» kidney biopsies from cadaver donors aged from 19 to 71 years old. In the pool of elderly donors who died from cerebrovascular accident the frequency of nephrosclerosis presentation was higher than in donors of yonger age who died from craniocephalic trauma. Nevertheless in the general donor pool the number of sclerosed glomeruli was no more than 12%. We did not meet at all in the whole volume of material any bi- opsy with the severe degree of arteriosclerosis. The «zero» biopsies of cadaver kidneys is quite usable and unexpensive tool to measure the degree of nephrosclerosis in order to exclude kidneys which are not fitable for transplantation. 

  13. Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

    Directory of Open Access Journals (Sweden)

    Amanda E Boe

    Full Text Available Nω-nitro-L-arginine methyl ester (L-NAME treatment induces arteriosclerosis and vascular senescence. Here, we report that the systemic inhibition of nitric oxide (NO production by L-NAME causes pulmonary emphysema. L-NAME-treated lungs exhibited both the structural (alveolar tissue destruction and functional (increased compliance and reduced elastance characteristics of emphysema development. Furthermore, we found that L-NAME-induced emphysema could be attenuated through both genetic deficiency and pharmacological inhibition of plasminogen activator inhibitor-1 (PAI-1. Because PAI-1 is an important contributor to the development of senescence both in vitro and in vivo, we investigated whether L-NAME-induced senescence led to the observed emphysematous changes. We found that L-NAME treatment was associated with molecular and cellular evidence of premature senescence in mice, and that PAI-1 inhibition attenuated these increases. These findings indicate that NO serves to protect and defend lung tissue from physiological aging.

  14. Genetic Susceptibility to Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Sanja Kovacic

    2012-01-01

    Full Text Available Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.

  15. Application of microwave sensor technology in cardiovascular disease for plaque detection

    Directory of Open Access Journals (Sweden)

    Wagner David

    2016-09-01

    Full Text Available Arteriosclerosis and associated cardiovascular disease remains the leading cause of mortality. Improved methods for vascular plaque detection allow early diagnose and better therapeutic options. Present diagnostic tools require intense technical expenditure and diminish value of modern screening methods. Our group developed an microwave sensor for on-site detection of plaque formation in arterial vessels. The sensor is an oscillator working around 27 GHz which is coupled to a microstrip stub line. The final flexible polyimid interposer has a length of 38 cm, a width of 1.2 mm and a thickness of 200 μm. Because of its minimal size the interposer completed a catheter with a diameter of 8F ready for further clinical use in cardiology and heart surgery.

  16. C-Peptide and Atherogenesis: C-Peptide as a Mediator of Lesion Development in Patients with Type 2 Diabetes Mellitus?

    Directory of Open Access Journals (Sweden)

    Nikolaus Marx

    2008-01-01

    Full Text Available Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show increased levels of C-peptide and over the last years various groups examined the effect of C-peptide in vascular cells as well as its potential role in lesion development. While some studies demonstrated beneficial effects of C-peptide, for example, by showing an inhibition of smooth muscle cell proliferation, others suggested proatherogenic mechanisms in patients with type 2 diabetes. Among them, C-peptide may facilitate the recruitment of inflammatory cells into early lesions and promote lesion progression by inducing smooth muscle cell proliferation. The following review will summarize the effects of C-peptide in vascular cells and discuss the potential role of C-peptide in atherogenesis in patients with type 2 diabetes.

  17. Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain

    Directory of Open Access Journals (Sweden)

    Eliasz Engelhardt

    Full Text Available Alois Alzheimer is best known for his description of neurofibrillary changes in brain neurons of a demented patient, identifying a novel disease, soon named after him by Kraepelin. However, the range of his studies was broad, including vascular brain diseases, published between 1894 and 1902. Alzheimer described the clinical picture of Arteriosclerotic atrophy of the brain, differentiating it from other similar disorders. He stated that autopsy allowed pathological distinction between arteriosclerosis and syphilis, thereby achieving some of his objectives of segregating disorders and separating them from syphilis. His studies contributed greatly to establishing the key information on vascular brain diseases, predating the present state of knowledge on the issue, while providing early descriptions of what would be later regarded as the dimensional presentation of the now called "Vascular cognitive impairment", constituted by a spectrum that includes a stage of "Vascular cognitive impairment not dementia" and another of "Vascular dementia".

  18. Diabetes mellitus in a black-footed ferret

    Science.gov (United States)

    Carpenter, J.W.; Novilla, M.N.

    1977-01-01

    Diabetes mellitus was tentatively diagnosed in a black-footed ferret with polyuria, polydipsia, polyphagia, dehydration, and weight loss. Laboratory findings (marked hyperglycemia (724 mg/100 ml), glycosuria, and ketonuria) and the subsequent favorable response to insulin therapy confirmed the diagnosis. Although lesions were not observed in the pancreas, gross and histologic findings concomitant with diabetes mellitus included arteriosclerosis, with calcification of the aorta and other major vessels; mild necrotizing hepatitis; and mild proliferative glomerulonephritis. A perineal adenocarcinoma, with metastasis to an internal iliac lymph node, was an incidental finding. Special stains demonstrated adequate numbers of beta cell granules in the islets of Langerhans. Thus, the diabetes was apparently due to a lack of release of the synthesized insulin or to diminished effectiveness of the secreted insulin.

  19. Probabilistic retinal vessel segmentation

    Science.gov (United States)

    Wu, Chang-Hua; Agam, Gady

    2007-03-01

    Optic fundus assessment is widely used for diagnosing vascular and non-vascular pathology. Inspection of the retinal vasculature may reveal hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. Due to various imaging conditions retinal images may be degraded. Consequently, the enhancement of such images and vessels in them is an important task with direct clinical applications. We propose a novel technique for vessel enhancement in retinal images that is capable of enhancing vessel junctions in addition to linear vessel segments. This is an extension of vessel filters we have previously developed for vessel enhancement in thoracic CT scans. The proposed approach is based on probabilistic models which can discern vessels and junctions. Evaluation shows the proposed filter is better than several known techniques and is comparable to the state of the art when evaluated on a standard dataset. A ridge-based vessel tracking process is applied on the enhanced image to demonstrate the effectiveness of the enhancement filter.

  20. Laser angioplasty for cardiovascular disease

    Science.gov (United States)

    Okada, Masayoshi

    2005-07-01

    Recently, endovascular interventions such as balloon angioplasty, atherectomy and the stenting method, except for conventional surgery have been clinically employed for the patients with atheromatous plaques of the peripheral- and the coronary arteries, because the number of patients with arteriosclerosis is now increasing in the worldwide. Among these procedures, restenoses after endovascular interventions have been remarkably disclosed in 20-40 % of the patients who underwent percutaneous coronary interventions. Thus, there are still some problems in keeping long-term patency by means of endovascular techniques such as balloon angioplasty and atherectomy (1, 2). For reduction of these problems , laser angioplasty using Argon laser was applied experimentally and clinically. Based on excellent experimental studies, laser was employed for 115 patients with stenotic ,or obstructive lesions occluding more thasn 75 % of the peripheral and the coronary arteries angiographycally.