WorldWideScience

Sample records for arteriosclerosis obliterans

  1. [Pathophysiology and diagnosis for arteriosclerosis obliterans].

    Science.gov (United States)

    Sasaki, Hisao; Konisi, Keiko

    2002-08-01

    Patients with arteriosclerosis obliterans, or peripheral arterial disease have been conventionally diagnosed and treated from only the viewpoint of peripheral arterial circulation. These concepts may have improved the quality of life for patients, but could not contribute the prognosis of life, because peripheral arterial disease is associated with an increased risk of the coronary disease and cerebrovascular disease. Intermittent claudication, the most common symptom of peripheral arterial disease, results from flow-reducing lesions in the arteries of the lower extremity that cause exercise-induced muscle ischemia. In order to evaluate intermittent claudication, many kinds of noninvasive diagnostic studies, including ABPI (ankle brachial pressure index) and the measurement of claudication distance, et al have been proposed. We have used the recovery time of the ischemic reaction at foot sole, plethysmography, thermography, laser doppler flowmetry, or NIRS (near-infrared spectroscopy) after walking test, rather than ABPI. These examinations will be superior to ABPI to evaluate effects after ergotherapy or pharmacotherapy for patients with intermittent claudication. Carotid artery sclerosis may be a good marker of systemic atherosclerosis. By our assessment of risk factors, the progression of atherosclerotic change in carotid artery was strongly correlated with two risk factors, such as smoking and systolic blood pressure. In the cholesterol analysis, Lp (a) was only high risk factor for atherosclerotic change of carotid artery. Recent technical advances, adequate evaluation of systemic atherosclerosis, and reduction of risk factors should improve the prognosis of patients with peripheral arterial disease. PMID:12373817

  2. [Correction of dyslipidemia in patients with arteriosclerosis obliterans as a method for improving the results of endovascular angioplasty].

    Science.gov (United States)

    Petukhov, V A; Seitmykhamedov, M D; Dibirov, A D; Dubovik, S G; Sergeeva, N A; Prokubovskiĭ, V I

    1992-01-01

    The authors analyse the results of endovascular angioplasty of the pelvic and lower limb arteries in 147 patients of various age suffering from arteriosclerosis obliterans. It was found that the results of endovascular angioplasty depended on the state of the lipid balance. The necessity for correcting the shifts in the lipid metabolism is shown. The article evaluates the results of dyslipidemia correction by dietotherapy, pharmacotherapy, and operation for partial ilio-shunting in patients with arteriosclerosis obliterans of the pelvic and lower limb arteries. The efficacy of the listed methods of treatment are analysed according to the severity of dyslipidemia. PMID:1457133

  3. Preliminary clinical application of SilverHawk directional atherectomy device in arteriosclerosis obliterans of lower extremity

    International Nuclear Information System (INIS)

    Objective: To evaluate the clinical efficiency and security of SilverHawk directional atherectomy device in treating arteriosclerosis obliterans of lower extremity. Methods: Seven patients with lower extremity ischemia were treated with SilverHawk directional atherectomy. The lesions length varied from 1.8 to 14.5 cm. Clinical symptoms (Fontaine classification) included 4 cases of grade Ⅱ b, I case of grade Ⅲ, 2 cases of grade Ⅳ. The ABI varied from 0.28 to 0.65. Patency was evaluated with color duplex sonography or CTA besides clinical examination during follow-up. Results: Seven occlusive lesions were recanalizated successfully. The technical success (residual stenosis < 30%) rate was 100%. Clinical symptoms were obviously improved or disappeared. The ABI varied from 0.82 to 1.18 (P=0.002), and Fontaine classification included 6 cases of Ⅰ; 1 case of Ⅱ a. Patency rate was 100% and the ABI varied from 0.75 to 1.14 (P=0.938). Fontaine classifications keep consistent 1-6 months after operation. Conclusion: SilverHawk directional atherectomy was a safe and effective way for treatment of lower arteriosclerosis obliteran. (authors)

  4. Clinical study of the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction

    International Nuclear Information System (INIS)

    To clarify the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction (CI), brain CT was performed and the risk factors for atherosclerosis were assessed. Thirty-five male and 5 female patients with intermittent claudication and/or leg ulceration were angiographically diagnosed as having ASO. According to CT findings, these patients were divided into three groups [no low-density areas (NLDA), hemorrhage, and infarction (CI)]. CI was subdivided as lacunar, cortical, and watershed infarction. Thirteen patients were in the NLDA group and 26 in the CI group (17 lacunar, 3 cortical and 6 mixed infarcts), indicating a CI incidence of 65%. Comparing the risk factors of the CI group with those of the NLDA group, hypertension (53.8%), diabetes (34.6%), and cigarette smoking (69.2%) was often seen in the CI group, although hypercholesterolemia (53.8%) and ischemic heart disease (42.3%) was the same in both groups. Multivariate analysis revealed that smoking had the strongest effect on the occurrence of CI in ASO patients. Furthermore, the number of combined risk factors (hypertension, diabetes, smoking, hypercholesterolemia) had a significant positive correlation with cortical infarction. As to the chronological relationship between the onset of ASO and CI, CI was present in 14 of 27 ASO patients on CT when the ischemic leg symptoms appeared, while symptomatic cortical infarction preceded ASO in 5 patients. CI patients increased gradually over a decade to 26 out of 40, among whom 16 patients with lacunae had silent infarcts. These findings suggested that ASO is frequently associated with CI, not only due to atherosclerosis of the main trunks of the cerebral vessels, but also due to arteriolosclerosis of the perforating arteries. (author)

  5. Prevention and nursing care of the complications occurred in interventional therapy for arteriosclerosis obliterans of lower extremity

    International Nuclear Information System (INIS)

    Objective: To discuss the prevention and nursing care of the perioperative complications occurred in interventional therapy for arteriosclerosis obliterans of lower extremity. Methods: During the period of July 2006 to June 2009, interventional treatment for the arteriosclerosis obliterans of lower extremity was performed in 380 cases. The clinical data and complications were reviewed and analyzed, and the prevention and nursing care of the complications were summarized. Results: Complications occurred in 41 cases. During the surgery, vascular rupture or arterial dissection occurred in 5 cases, hypoglycemia reaction in 3 cases and elevation of blood pressure in 2 cases. The complications,which occurred after the treatment,included acute arterial thrombosis (n=3), deep vein thrombosis (n=2), bleeding of different tissues or organs (n=17), acute myocardial infarction (n=2), pseudoaneurysm (n=2), excessive lower limb perfusion syndrome (n=4) and compression sores (n=1). Conclusion: Detailed information of medical history, careful observation of clinical condition, intensive care of patient, adequate preparation of medical materials, seriously handing over the duty to the next shift and taking one's turn on duty, etc. are all the effective measures to prevent and to reduce the occurrence of complications. (authors)

  6. A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol

    Institute of Scientific and Technical Information of China (English)

    Xiao-Wei Ma; Xiao-Hui Guo; Xin-Hua Xiao; Li-Xin Guo; Xiao-Feng Lv; Quan-Min Li; Yan Gao

    2012-01-01

    Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks. Results Of the 200 randomized patients, 165 for per-protocol and 160 for the safety (QTc intervals) were set, respectively. Probucol significantly reduced total cholesterol (P < 0.001), low-density lipoprotein cholesterol (LDL-C), (P = 0.01), and high-density lipoprotein cholesterol (HDL-C) (P < 0.001) compared with conventional therapy. Cilostazol was effective in increasing HDL-C (P = 0.002) and reducing triglycerides levels (P < 0.01) compared with conventional therapy. A trend towards significance was observed for the difference between conventional therapy alone and Probucol plus Cilostazol group for the change in oxidized low-density lipoprotein (Ox-LDL, P = 0.065). No significant effects on the majority of the remaining biomarkers were found across the treatment groups. Conclusions We have confirmed that Ox-LDL could be a possible plasma atherosclerotic biomarker among the evaluated biomarkers, which reflected the synergetic effect of Cilostazol plus Probucol in patients with T2DM and ASO shown previously in preclinical studies.

  7. Usefulness of preoperative coronary angiography and brain computed tomography in cases of coronary artery disease and cerebrovascular disease undergoing revascularization for arteriosclerosis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    Sakurada, Tall; Shibata, Yoshiki [Southern Tohoku Fukushima Hospital (Japan)

    2003-05-01

    Coronary angiography and brain computed tomography were preoperatively performed to evaluate the clinical condition of coronary artery disease and cerebrovascular disease in 101 patients (mean age, 68.4 years) with revascularization for arteriosclerosis obliterans. Eighty patients had hypertension, 12 had diabetes, and 26 had hyperlipidemia. Seventy-one patients (70.3%) had coronary stenosis. Significant stenoses in major coronary artery branches were confirmed in 35 patients, including 13 patients with old myocardial infarction. Coronary artery bypass grafting and percutaneous coronary angioplasty were performed in 2 and 7 patients with critical stenosis, respectively. Of 57 patients, who underwent brain computed tomography, abnormalities were found in 52 patients (91.2%), including cortical infarction in 9, lacunar infarction in 35, and leukoaraiosis in 27 patients. During the follow-up period 13 patients died (including 3 cases of myocardial infarction and 3 cases of stroke). Actuarial survival rate at 5 years was 80.4%. The influence of ischemic heart disease and cerebrovascular disease on early and late mortality after surgical reconstruction for peripheral occlusive vascular disease is significant. Using visual diagnostic techniques, such as coronary angiography and brain computed tomography, long term survivor should be closely observed for multiple arteriosclerotic vascular diseases. (author)

  8. Cerebrovascular diseases in patients with arteriosclerotic aortic aneurysm and arteriosclerosis obliterans studied by carotid ultrasonography and by computed tomography of the brain

    International Nuclear Information System (INIS)

    To estimate the incidence of cerebrovascular diseases in arteriosclerotic aortic aneurysm (AA) and arteriosclerosis obliterans (ASO) and their characteristics, 92 patients with AA and 102 patients with ASO were studied with carotid ultrasonography and brain computed tomography (CT), and were compared with 49 patients with hypertension. The mean ages of the patients were 70 to 72 years old and all were male. Hypertension was common in the AA group; diabetes and cigarette smoking were common in the ASO group. Carotid plaque lesions seen on ultrasonography were significantly more common in the AA (66%) and ASO (85%) groups than in the patients with hypertension (39%). The mean carotid diameter was significantly greater in the AA group than in the other two groups. The mean wall thicknesses in the AA and ASO groups were greater than in the patients with hypertension. Computed tomography showed that low-density areas were also common in the AA group (56%) and ASO (53%) groups than in the patients with hypertension (24%). Most of the low-density areas were thought to be lacunae or dilated perivascular spaces in the subinsula and putamen. Moderately and highly severe periventricular lucencies were also common in the AA group. These findings indicate that carotid changes, seen in AA and ASO, reflected the characteristics of arterial lesions, and that arteriosclerotic lesions were common in patients with AA and ASO. Therefore, cerebrovascular diseases should be taken into account in the management of patients with AA and ASO. (author)

  9. Cerebrovascular diseases in patients with arteriosclerotic aortic aneurysm and arteriosclerosis obliterans studied by carotid ultrasonography and by computed tomography of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, Toshihiko; Sugiyama, Tsuyoshi; Oyama, Tetsuo; Takasaki, Masaru [Tokyo Medical Coll. (Japan)

    1998-09-01

    To estimate the incidence of cerebrovascular diseases in arteriosclerotic aortic aneurysm (AA) and arteriosclerosis obliterans (ASO) and their characteristics, 92 patients with AA and 102 patients with ASO were studied with carotid ultrasonography and brain computed tomography (CT), and were compared with 49 patients with hypertension. The mean ages of the patients were 70 to 72 years old and all were male. Hypertension was common in the AA group; diabetes and cigarette smoking were common in the ASO group. Carotid plaque lesions seen on ultrasonography were significantly more common in the AA (66%) and ASO (85%) groups than in the patients with hypertension (39%). The mean carotid diameter was significantly greater in the AA group than in the other two groups. The mean wall thicknesses in the AA and ASO groups were greater than in the patients with hypertension. Computed tomography showed that low-density areas were also common in the AA group (56%) and ASO (53%) groups than in the patients with hypertension (24%). Most of the low-density areas were thought to be lacunae or dilated perivascular spaces in the subinsula and putamen. Moderately and highly severe periventricular lucencies were also common in the AA group. These findings indicate that carotid changes, seen in AA and ASO, reflected the characteristics of arterial lesions, and that arteriosclerotic lesions were common in patients with AA and ASO. Therefore, cerebrovascular diseases should be taken into account in the management of patients with AA and ASO. (author)

  10. Usefulness of preoperative coronary angiography and brain computed tomography in cases of coronary artery disease and cerebrovascular disease undergoing revascularization for arteriosclerosis obliterans

    International Nuclear Information System (INIS)

    Coronary angiography and brain computed tomography were preoperatively performed to evaluate the clinical condition of coronary artery disease and cerebrovascular disease in 101 patients (mean age, 68.4 years) with revascularization for arteriosclerosis obliterans. Eighty patients had hypertension, 12 had diabetes, and 26 had hyperlipidemia. Seventy-one patients (70.3%) had coronary stenosis. Significant stenoses in major coronary artery branches were confirmed in 35 patients, including 13 patients with old myocardial infarction. Coronary artery bypass grafting and percutaneous coronary angioplasty were performed in 2 and 7 patients with critical stenosis, respectively. Of 57 patients, who underwent brain computed tomography, abnormalities were found in 52 patients (91.2%), including cortical infarction in 9, lacunar infarction in 35, and leukoaraiosis in 27 patients. During the follow-up period 13 patients died (including 3 cases of myocardial infarction and 3 cases of stroke). Actuarial survival rate at 5 years was 80.4%. The influence of ischemic heart disease and cerebrovascular disease on early and late mortality after surgical reconstruction for peripheral occlusive vascular disease is significant. Using visual diagnostic techniques, such as coronary angiography and brain computed tomography, long term survivor should be closely observed for multiple arteriosclerotic vascular diseases. (author)

  11. 动脉硬化性闭塞症患者的健康教育效果评价%Evaluation of Health Education on Patients with Arteriosclerosis Obliterans

    Institute of Scientific and Technical Information of China (English)

    李爱然

    2011-01-01

    目的 观察动脉硬化性闭塞症患者健康教育的效果.方法随机选取符合条件的动脉硬化性闭塞症患者35例,由专职人员进行健康教育,包括饮食、运动、心理等指导.结果动脉硬化性闭塞症患者接受健康教育后,知识知晓率提高了28.58%、健康教育前后经配对秩和检验,差异有统计学意义(Z=-5.716,P<0.01);遵医行为明显改善(Z=-5.333,P<0.01)、自我管理能力有所提高(Z=-2.200,P<0.05),血脂降低(Z= -3.79,P<0.01),3方面差异均有统计学意义.结论通过对动脉硬化性闭塞症患者的健康教育,增加了患者治疗的信心,减轻了症状,增强了保健意识,提高了生活质量.%[Objective]To observe the health education effect on patients with arteriosclerosis obliterans. [Methods] A total of 35 eligible patients with atherosclerotic occlusion were randomly selected who were educated about health knowledge, including diet, ex-ercice and psychological guidance, by full-time staff, [Results] After health education, awareness rate of patients with arteriosclero-sis obliterans increased by 28. 38% which was significant before and after health education by the paired Wilcoxon test (Z = -5. 716,P= 0.001). Compliance Behavior of patients had improved (Z = -5.333, P = 0.001). Self-management of patients had enhanced(Z= -2.200, P=0.028). Serum lipids of patients had reduced (Z= -3.79,P = 0.001). These differences were all significant. [ Conclusion] Health education on patients with arteriosclerosis obliterans increases their confidence in the treatment, relieves symptoms, increases their health awareness and improves their quality of life.

  12. Evaluation of percutaneous transluminal angioplasty for treatment of infrapopliteal arteriosclerosis obliterans%经皮腔内血管成形术治疗膝下动脉粥样硬化闭塞症的评价

    Institute of Scientific and Technical Information of China (English)

    张玉超; 黄英; 李维敏; 陆信武; 黄新天; 陆民; 蒋米尔

    2012-01-01

    Objective To assess the therapeutic effect of percutaneous transluminal angioplasty ( PTA )on the treatment of infrapopliteal arteriosclerosis obliterans( ASOs ). Methods From Jan. 2007 to Jun. 2011, clinical data of patients with infrapopliteal ASO undergoing PTA at our department were retrospectively reviewed. Results Infrapopliteal PTA was performed on 138 lower limbs for 138 patients( mean age,77. 31 ±7. 52 year - old ). The mean diameter of balloon catheters used for infrapopliteal arteries was 2. 8 mm( 2 mm ~4 mm ), with the mean length of 110. 6 mm( 40 mm ~ 170 mm ). There were no severe complications occurring intraoperatively or postoperatively. Early results showed that all patients had significant improvement in ischemic symptoms( 100% ), and no patients had limb loss. During a mean follow -up of 24. 1 months( 4 ~ 58 months ), the rate of improvement in ischemic symptoms for treated limbs was 78. 4% and the limb salvage rate was 93. 9% at 2 years. Conclusion Minimal invasive PTA for the treatment of infrapopliteal ASO is safe and effective for improving ischemic symptoms of lower limbs and limb salvage.%目的 评价经皮腔内血管成形术(percutaneous transluminal angioplasty,PTA)治疗膝下动脉粥样硬化闭塞症(arteriosclerosis obliterans,ASO)的疗效.方法 回顾性研究2007年1月至2011年6月我科收治的累及膝下动脉ASO并行PTA治疗的患者的临床资料.结果 138例患者,平均年龄(77.31±7.52)岁,治疗膝下动脉所用球囊平均直径 2.8mm(2~4mm),平均长度110.6mm(40~170mm),术中及术后无严重并发症.术后早期治疗肢体临床症状明显改善率为100%,无截肢患者.平均随访24.1个月(4~58个月),治疗肢体术后2年临床症状明显改善率78.4%,救肢率93.9%.结论 PTA治疗膝下动脉ASO可有效改善临床缺血症状并提高救肢率.

  13. 下肢动脉硬化性闭塞症介入治疗的回顾性分析%Interventional Revascularization of the Lower Limbs Arteriosclerosis Obliterans:A Retrospective Study

    Institute of Scientific and Technical Information of China (English)

    吴正阳; 鲁海涛; 朱悦琦; 谭华桥; 赵俊功

    2012-01-01

    目的 回顾性分析下肢动脉硬化性闭塞症(arteriosclerosis obliterans,ASO)介入治疗的临床疗效和通畅率.方法 从2009年10月到2011年7月,32例(39条下肢)下肢ASO患者在上海交通大学附属第六人民医院行介入治疗.回顾性分析32例ASO患者的血管造影图像,根据病变长度和程度分级.对手术成功患者随访,随访期3 ~16个月,平均随访期(8.7±1.9)个月.随访期内每3个月进行一次下肢MRA或CTA检查,并搜集相关临床资料.结果 技术成功率93%,踝肱指数(ankle-brachial index,ABI)从术前的0.47±0.11提高至术后的0.68±0.02,在随访期末20例取得了稳定疗效,总的通畅率为77%,保肢率为97%.结论 介入治疗ASO安全可行,取得了良好的临床效果及通畅率,其长期疗效尚需进一步观察.%Objective To retrospectively evaluated the clinical efficacy of interventional revascularization for lower limbs arteriosclerosis obliterans (ASO). Methods From Oct 2009 to July 2011, 32 patients (39 limbs) with lower limbs ASO performed interventional revascularization in our center. Angiography was retrospectively analyzed, and every lesion categorized and classified according to its length and severity. The mean follow up period was 3 - 162 months, mean 8.7 ± 1.9 months. Lower limb magnetic resonance angiography (MRA) or computed tomography angiography (CTA) was performed every 3 months during follow-up. The clinical data were collected. Results 93% technical success rate was obtained. Ankle-brachial index (ABI) improved from 0. 47 ±0. 11 to 0. 68 ± 0. 02. At the end of follow up, 20 patients maintained a stable outcome, gained a 77% patency rate and 97% limb salvage rate. Conclusion Interventional revascularization is safe and feasible in the treatment of lower limbs ASO. With encouraging clinical outcome and patency rate, further research is warranted to evaluate long-term outcome.

  14. 杂交手术治疗下肢多节段动脉闭塞32例%Hybrid operation for the treatment of multifocal lesions in arteriosclerosis obliterans of the lower extremity

    Institute of Scientific and Technical Information of China (English)

    唐波; 刘冰; 王海洋; 单鹏; 王海君; 李海斌; 王青山; 黄任平; 韩鹏

    2011-01-01

    Objective To evaluate hybrid operation for arteriosclerosis obliterans (ASO) of the lower extremity. Methods Clinical data of 35 ischemic limbs in 32 ASO cases receiving hybrid operation from May, 2007 to August, 2009 were retrospectively analysed. The indications, clinical result,complications, perioperative mortality, vascular patency rate and limb salvage rate was evaluated.Results Thirty-five ischemic limbs in 32 cases underwent hybrid operation. Procedures were successful in 94% cases (33/35). The average postoperative ABI significantly increased from 0.49 ±0. 18 to 1.06 ± 0. 17 ( one day after surgery) or 0. 96 ± 0. 16 ( six months after therapy). One patient suffered limb amputation due to surgical failure, one case was complicated with cerebral infarction and the operation was terminated. No patient died in perioperative period. Twenty-six cases (28 ischemia limbs) were followed-up from 2 month to 28 months, the follow-up rate was 87% (26/30). Vascular patency rate in 6 months after operation was 93% (26/28), and limb salvage rate was 96% (27/28). Two cases suffered from below-knee reocclusion 5 -6 months after therapy, and one of these two cases needed a limb amputation.Conclusion Hybrid operation is the therapy of choice for multifocal lesions in arteriosclerosis obliterans of the lower extremities with a low risk and higher patency in short term.%目的 探讨杂交手术对下肢多节段动脉闭塞性病变的治疗效果.方法 回顾性分析2007年5月至2009年8月接受杂交手术的32例(35条下肢)多节段动脉闭塞性病变的临床资料,探讨杂交手术的适应证、治疗效果、并发症、围手术期死亡率、血管通畅率及保肢率.结果 33条患肢获得手术成功,成功率为94%(33/35).患者术后次日、术后6个月的踝肱指数(ABI)分别为1.06±0.17与0.96±0.16.与术前(0.49±0.18)相比,差异有统计学意义(P<0.05).2例手术失败中1例因术中并发脑梗死,终止手术;1例膝下

  15. Arteriosclerosis Detection

    Science.gov (United States)

    1976-01-01

    The Veterans Administration Hospital used computer image-processing techniques to detect arteriosclerosis. Originally developed by Goddard Space Flight Center engineers to enhance spacecraft pictures, this device replaced the previous testing for this disease which was extremely painful and time consuming. With this instrument, computer detected edges are shown along with an estimate of location of pre-arteriosclerosis vessel wall. The difference between the two represents the relative amount of disease in the blood vessel. Instrumentation will be expanded again in 1976 to analyze the coronary arteries and the blood vessels of the retina.

  16. Cerebral Arteriosclerosis

    Science.gov (United States)

    ... the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in ...

  17. 腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的临床诊治%Clinical treatment of the intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans

    Institute of Scientific and Technical Information of China (English)

    倪东馗; 吴义生; 庞小建; 李立军

    2010-01-01

    Objective To explore the principle of diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans. Method Eighteen cases of patients with intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans, using MRI and MRA, to determine the main reason due to of disease, to take the treatment for the cause. Results The patients were followed up for 7 to 24 months, average (16.0 ± 4.7) months. Assessed according to the modified MacNab criteria of clinical efficacy, excellent in 7 cases, good in 8 cases, general in 3 cases,satisfactory rate was 83.3%(15/18). Intermittent claudication were improved with all patients, walking distance of more than 1000 meters, relief rate was 100%. Postoperative ankle brachial score(0.90±0.54 ) was obviously increased compared with preoperative average(0.58±0.36), there was significant statistical difference(P<0.01). All cases were not amputee due to circulation disturbance. Conclusion The diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans,it is necessary to collect a history of serious and careful investigation,combined with imaging, can accurately determine the responsibility of lesions, target to give the appropriate treatment, can get a good effect%目的 探讨腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的诊治原则.方法 对18例患有腰椎疾病同时合并下肢动脉闭塞症的患者,利用MRI和MRA检查判定所致患者疾病的主要病因,采取针对病因的适宜治疗.结果 本组病例全部获得随访,随访时间7~24(16.0±4.7)个月.按改良MacNab标准评定临床疗效,优7例,良8例,可3例,优良率为83.3%(15/18).全部病例间歇性跛行明显改善,行走距离超过1000m,改善率100%.术后踝肱指数(ABI)0.90±0.54,较术前(0.58±0.36)明显增

  18. Effects of cilostazol on the highsensitive creactive protein, blood lipid and matrix metalloproteinase-9 in elderly patients with lower extremity arteriosclerosis obliterans%西洛他唑对老年下肢动脉硬化闭塞症患者超敏C反应蛋白、血脂及基质金属蛋白酶-9的影响

    Institute of Scientific and Technical Information of China (English)

    刘永升; 魏梅; 刘会英; 岳媛媛; 王乐; 张慧敏

    2012-01-01

    目的 探讨西洛他唑对老年下肢动脉硬化闭塞症患者超敏C反应蛋白(Hs-CRP)、血脂及基质金属蛋白酶9(MMP-9)的影响. 方法 选择老年下肢动脉硬化闭塞症患者60例,随机分为基本治疗组和西洛他唑组,同时以30例健康体检人员作为对照组.观察治疗后各组Hs-CRP、血脂及MMP-9的变化. 结果 治疗后基本治疗组血脂变化不明显,西洛他唑组总胆固醇(TC)水平明显下降,高密度脂蛋白胆固醇(HDL-C)显著上升.治疗后2组Hs-CRP、MMP-9水平均明显下降,西洛他唑组下降幅度大于基本治疗组. 结论 西洛他唑通过降低炎性因子浓度,调解血脂,降低Hs-CRP、MMP-9等途径改善下肢血管病变患者症状.%Objective To observe the effects of Cilostazol on the highsensitive creactive protein ( Hs-CRP) , blood lipid and matrix metalloproteinase-9 ( MMP-9) in elderly patients with lower extremity arteriosclerosis obliterans. Methods Sixty aged patients with lower extremity arteriosclerosis obliterans were randomly assigned to conventional therapy group (group A) and Cilostazol group (group B). Thirty healthy people were selected as the normal group. Hs-CRP, blood lipid and MMP-9 in blood serum were measured be fore and after therapy. Results After therapy the level of blood lipid in blood serum of group A had not a marked change. But the level of high density lipoprotein of group B increased obviously. At the same time the level of Hs-CRP and MMP-9 decreased. The degree of decrease in group B was more significant than that in group A. Conclusions The therapy of Cilostazol can adjust blood lipid metabolism, decrease inflammatory factors and improve symptoms.

  19. The effects of different hydration strategies before endovascular treatments to the renal function of the arteriosclerosis obliterans patients%下肢动脉硬化闭塞症腔内治疗不同水化方案对患者肾功能的影响

    Institute of Scientific and Technical Information of China (English)

    朱雅亭; 熊江; 郭伟; 刘小平; 尹太; 贾鑫; 马晓辉; 杜昕

    2010-01-01

    Objective To compare the efficacies of different hydration strategies in protecting the renal function of the arteriosclerosis obliterans(ASO) patients undergoing endovascular treatments. Methods 40 patients who underwent endovascular treatments for arteriosclerosis obliterans of lower extremities in the Vascular Surgery Department of PLA Hospital from January 2009 to October 2009 were divided into normal (eerumcreatinine≤110 μmol/L) and abnormal (serum creatine > 110 μmol/L) groups according to their baseline serum concentration of creatinine before treatments. Each group was treated by different hydration strategies 12 h before procedures. Changes of serum creatinine and creatinine clearance were measured 6,24,48 h after procedures to evaluate the changes of renal function and the effects of different hydration strategies. Results No contrast-induced nephopathy (CIN) was observed among the 40 patients. There are significant differences between normal saline hydration group and control group in the changes of serum creatinine and creatinine clearance 24 h and 48 h after exposure to contrast medium for the normal renal function patients ( P < 0. 05 ). For the patients pre-existing renal dysfunction, no significant difference was found between Sodium Bicarbonate + Saline group and Saline group in the changes of Scr and Ccr 6,24,48 h after exposure to contrast medium(P >0. 05). Conclusion Sodium chloride provides a good efficacy for preventing the adverse effect of contrast medium to the renal function of theASO patients. For the patients pre-existing renal dysfunction, Combination hydration with sodium bicarbonate is not more effective than normal saline alone in preventing contrast-induced renal dysfunction.%目的 比较不同水化方案对行腔内治疗的下肢动脉硬化闭塞症(ASO)患者肾功能的保护作用.方法 2009年1-10月解放军总医院血管外科行腔内治疗的40例ASO患者,根据术前基础肌酐水平分

  20. Thromboangiitis obliterans (Buerger's disease)

    OpenAIRE

    Sinclair, Nicholas R.; Laub, Donald R

    2016-01-01

    Thromboangiitis Obliterans is a non-atherosclerotic inflammatory disease of unknown etiology, which has a strong association with tobacco. We present current concepts on the pathophysiology and diagnosis, as well as a review in treatments.

  1. [Arteriosclerosis obliterans. Treatment with angiotensin-converting enzyme inhibitors].

    Science.gov (United States)

    Orea, A; Valdés, R; Niebla, L; Rivas, R; Camacho, B

    1990-01-01

    We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor. We studied 22 patients: all of them with hypertension and/or skin ulcerations, dropping out those who had venous. They were evaluated periodically, clinically and with photoelectric plethysmography of lower extremities. To interpret the traces we designed an ideogram which gathered the plethysmographic behavior before and after the treatment. Nearly 80% showed considerable improvement in pain, functional capacity and plethysmographic traces patterns. healing of the ulcerations was achieved in all case. We propose some hypothesis to explain the good effect that we have observed.

  2. [Helicobacter pylori and Arteriosclerosis].

    Science.gov (United States)

    Matsui, Teruaki

    2011-03-01

    Helicobacter pylori (H. pylori) infection-related diseases are known to include gastritis, gastric and duodenal ulcer, gastric cancer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, iron-deficient anemia, urticaria, reflux esophagitis, and some lifestyle-related diseases. It is indicated that homocysteine involved with arteriosclerosis induces lifestyle-related diseases. Homocysteine is decomposed to methionine and cysteine (useful substances) in the liver, through the involvement of vitamin B₁₂ (VB₁₂) and folic acid. However, deficiency of VB₁₂ and folic acid induces an increase in unmetabolized homocysteine stimulating active oxygen and promoting arteriosclerosis. VB₁₂ and folic acid are activated by the intrinsic factors of gastric parietal cells and gastric acid. The question of whether homocysteine, as a trigger of arteriosclerosis, was influenced by H. pylori infection was investigated. H. pylori infection induces atrophy of the gastric mucosa, and the function of parietal cells decreases with the atrophy to inactivate its intrinsic factor. The inactivation of the intrinsic factor causes a deficiency of VB₁₂ and folic acid to increase homocysteine's chances of triggering arteriosclerosis. The significance and usefulness of H. pylori eradication therapy was evaluated for its ability to prevent arteriosclerosis that induces lifestyle-related diseases. Persons with positive and negative results of H. pylori infection were divided into a group of those aged 65 years or more (early and late elderly) and a group of those under 65 years of age, and assessed for gastric juice. For twenty-five persons from each group who underwent gastrointestinal endoscopy, the degree of atrophy of the gastric mucosa was observed. Blood homocysteine was measured as a novel index of arteriosclerosis, as well as VB₁₂ and folic acid that affect the metabolism of homocysteine, and then activated by gastric acid and intrinsic factors. Their

  3. [Hypertension and arteriosclerosis].

    Science.gov (United States)

    Sasamura, Hiroyuki; Itoh, Hiroshi

    2011-01-01

    Hypertension is a known risk factor for arteriosclerosis, and causes both atherosclero= sis of medium-large arteries and arteriolosclerosis of the arterioles. Elevated blood pressure causes damage to the endothelium and vascular wall through both mechanical and humoral factors. We and others have shown that inhibition of the renin-angiotensin system at a 'critical period' during the development of hypertension results in a permanent suppression of hypertension in animal models. We have also reported that high-dose renin-angiotensin inhibition results in regression of hypertension, possibly by regression of renal arteriolar hypertrophy. These results suggest that understanding the process of arterial remodeling may play a key role in the development of new strategies for prevention and regression of hypertension and arteriosclerosis.

  4. Arteriosclerosis in Seven Cattle

    OpenAIRE

    Bundza, Adam; Stevenson, Daniel A.

    1987-01-01

    Sporadic arteriosclerosis of the aorta, with or without pulmonary ossification, occurred in seven cattle from slaughter-houses and farms. Aortic walls were thickened, and had many white or yellow mineralized plaques on the intimal surface. The lungs did not collapse, were firm, gritty and crepitant on palpation, and sponge-like in appearance on cross section. Microscopically, the aortas had mineral deposits in the tunica intima and media, varying in size and structure and surrounded by fibrou...

  5. Thromboangiitis obliterans (Buerger disease

    Directory of Open Access Journals (Sweden)

    Jessica Seebald, BS

    2015-10-01

    Full Text Available Thromboangiitis obliterans (Buerger disease is an occlusive, nonatherosclerotic, inflammatory vasculitis that causes ischemia in small and medium vessels. Most commonly, Buerger disease is diagnosed in 40- to 45-year-old men with a heavy smoking history. Our case exemplifies the most common presentation, diagnosis, and treatment in a 53-year-old male smoker who presents with arm pain and dusky cool fingers. A Buerger diagnosis requires exclusion of autoimmune, diabetic, and embolic causes. The only recognized treatment for this disease is smoking cessation.

  6. Stem cells and transplant arteriosclerosis.

    Science.gov (United States)

    Xu, Qingbo

    2008-05-01

    Stem cells can differentiate into a variety of cells to replace dead cells or to repair damaged tissues. Recent evidence indicates that stem cells are involved in the pathogenesis of transplant arteriosclerosis, an alloimmune initiated vascular stenosis that often results in transplant organ failure. Although the pathogenesis of transplant arteriosclerosis is not yet fully understood, recent developments in stem cell research have suggested novel mechanisms of vascular remodeling in allografts. For example, stem cells derived from the recipient may repair damaged endothelial cells of arteries in transplant organs. Further evidence suggests that stem cells or endothelial progenitor cells may be released from both bone marrow and non-bone marrow tissues. Vascular stem cells appear to replenish cells that died in donor vessels. Concomitantly, stem/progenitor cells may also accumulate in the intima, where they differentiate into smooth muscle cells. However, several issues concerning the contribution of stem cells to the pathogenesis of transplant arteriosclerosis are controversial, eg, whether bone marrow-derived stem cells can differentiate into smooth muscle cells that form neointimal lesions of the vessel wall. This review summarizes recent research on the role of stem cells in transplant arteriosclerosis, discusses the mechanisms of stem cell homing and differentiation into mature endothelial and smooth muscle cells, and highlights the controversial issues in the field.

  7. Atorvastatin calcium plus calcium dobesilate in arteriosclerosis obliterans in lower extremity of diabetes mellitus%阿托伐他汀钙联合羟苯磺酸钙治疗糖尿病下肢动脉硬化闭塞症对照研究

    Institute of Scientific and Technical Information of China (English)

    王学芳

    2015-01-01

    目的:探讨阿托伐他汀钙联合羟苯磺酸钙治疗糖尿病下肢动脉硬化闭塞症的临床疗效。方法将30例2型糖尿病下肢动脉硬化闭塞症患者随机分为治疗组18例和对照组12例,两组均予以诺和灵30 R皮下注射治疗,治疗组在此基础上口服阿托伐他汀钙、羟苯磺酸钙治疗,观察16周。检测两组腓总神经感觉传导速度、踝臂指数、趾臂指数及血糖、血脂的变化。结果治疗后两组腓总神经感觉传导速度、踝臂指数、趾臂指数均较治疗前显著提高(P<0.05或0.01),治疗组较对照组提高更显著(P<0.01);治疗组脉博波传导速度较治疗前显著下降(P<0.01),对照组则无显著变化(P>0.05)。治疗组总胆固醇、三酰甘油、低密度脂蛋白水平均较治疗前显著下降(P<0.01),对照组虽较治疗前有所下降,但差异无显著性(P>0.05)。结论阿托伐他汀钙联合羟苯磺酸钙治疗能有效改善糖尿病下肢动脉硬化闭塞症患者下肢缺血状况。%Objective To explore the efficacy of atorvastatin calcium plus calcium dobesilate in arterioscle‐rosis obliterans in lower extremity (AOLE) of diabetes mellitus (DM ) .Methods Thirty type 2 DM pa‐tients with AOLE were randomly assigned to treatment (n=18) and control group (n=12) ,both groups were treated with isophane protamine biosynthetic human insulin injection (pre‐mixed30R) ,on this basis treatment group took orally atorvastatin calcium plus calcium dobesilate foe 16 weeks .Changes of common peroneal nerve sensory conduction velocity (SCV) ,ankle‐brachial index (ABI) ,toe brachial index (TBI) , blood glucose and blood fat were detected .Results After treatment SCV ,ABI and TBI of both groups heightened more significantly compared with pretreatment (P0 .05) .Cholesterol total ,triacylglycerol and low density lipoprotein level lowered more significantly in treatment (P0 .05) .Conclusion

  8. [Portable instrument for arteriosclerosis assessment].

    Science.gov (United States)

    Cao, Shuai; Chen, Xiang

    2014-01-01

    A portable instrument for arteriosclerosis assessment containing sensor module, acquisition board and embedded module was developed for home care in this paper. The sensor module consists of one ECG module and three pulse wave extraction modules, synchronously acquiring human ECG and pulse wave signal of carotid, radial, and dorsal, respectively. The acquisition board converts the sensor module's analog output signals into digital signals and transmits them to the embedded module. The embedded module realizes the functions including signal display, storage and the calculation and output of pulse wave velocity. The structure of the proposed portable instrument is simple, easy to use, and easy to expand. Small size, low cost, and low power consumption are also the advantages of this device. Experimental results demonstrated that the proposed portable instrument for arteriosclerosis assessment has high accuracy, good repeatability and can assess the degree of atherosclerosis appropriately.

  9. Angioscopic assessment of various percutaneous treatments for arteriosclerosis obliterance

    Science.gov (United States)

    Kusaba, Hiroyasu; Watanabe, Kazuo; Shiraishi, Shohzo; Sato, Takashi; Koga, Nobuhiko

    1993-06-01

    We have evaluated the angioscopic findings before and after various percutaneous techniques to treat 39 lesions in 32 cases of arteriosclerosis obliterans (ASO). We applied a laser (CL50: SLT, Japan), percutaneous transluminal angioplasty (PTA), and atherectomy -- either singly or in combination, with angioscopic luminal observation (angioscope: PF14L & PF18L Olympus, Japan) recorded before and after the treatments. In the case of a complete obstruction, we employed PTA as the first choice. We used a laser prior to PTA when the PTA guide-wire failed to penetrate the lumen. For eccentric and calcified lesions atherectomy was applied. A sufficient enlargement was obtained initially in 37 of the 39 lesions. The angioscopic observations after treatment revealed carbonization (3/5) and attachment of small thrombi (3/5) after using the laser, intimal rupture (3/8), dissection (2/8), flap formation (2/8), and attachment of small thrombi (4/8) after PTA, and attachment of small thrombi (9/19), flap formation (6/19), and dissection (2/19) after atherectomy. We established the efficacy of angioscopic assessment demonstrating beneficial clinical results. The angioscopic findings suggest that attachment of small thrombi may be responsible for a poor prognosis. Additional angioscopic observations with angiography are recommended for improved understanding of the luminal changes.

  10. CT angiography in the diagnosis of lower extremity arteriosclerosis obliterans: a Meta analysis

    International Nuclear Information System (INIS)

    Objective: To systematically assess the diagnostic performance of CTA for lower extremity peripheral arterial disease (PAD) using a Meta analysis method. Methods: Studies were located through electronic searching of the PubMed, EBSCO, Springer, Ovid, CNKI, Cochrane library (from the date of establishment of the databases to October 2009). Bibliographies of the retrieved articles were also checked. All the studies concerning the diagnosis of PAD using CTA had been searched and reviewed, and the studies with the DSA as the gold standard were adopted as eligible. Subsequently, the characteristics of the included articles were appraised and extracted. Data on accuracy of included studies were extracted for further heterogeneity exploring, statistical pooling and SROC (summary receiver operating characteristics) analyzing using the Meta Disc 1.4 software. Results: Totally 24 studies met the inclusion criteria with a total of 1096 patients. The heterogeneity was found in these studies. The pooled accuracy indicators like sensitivity, specificity, and diagnostic odds ratio (DOR) were 0.95 (95% CI: 0.94-0.95), 0.96 (95% CI: 0.95-0.96), and 471.13 (95% CI: 242.92-913.71), respectively. The area under of SROC curve was 0.9888 and the Q index was 0.9555. Subgroup analysis demonstrated significant difference on diagnostic performance for various CT slices (P<0.05). Conclusion: CTA can be regarded as an effective and feasible method for PAD diagnosis and screening, based on the results of this systematic review. However, more rigorous evaluations of CTA in patients with critical limb ischemia are needed. (authors)

  11. Cerebrovascular hemodynamics in patients with cerebral arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    Jianbo Yang; Changcong Cui; Chengbin Wu

    2011-01-01

    The present study observed hemodynamic changes in 26 patients with cerebral arteriosclerosis using a cerebral circulation dynamics detector and transcranial Doppler.In patients with cerebral arteriosclerosis the blood supply and flow rate in the bilateral carotid arteries and the blood flow rate in the anterior cerebral and middle cerebral arteries were similar to normal controls, but the cerebral vascular resistance, critical pressure and pulsatility index were increased, and cerebral arterial elasticity and cerebral blood flow autoregulation were decreased.Compared with the lesioned hemisphere of patients with cerebral infarction, the total blood supply and blood flow rate of patients with cerebral arteriosclerosis were higher.Compared with normal subjects, patients with cerebral arteriosclerosis exhibited cognitive disturbances, mainly in short-term memory, attention, abstract capability, and spatial and executive dysfunction.Results showed that cerebral arteriosclerosis does not directly affect the blood supply of a cerebral hemisphere, but affects cognitive function.The increased cerebral vascular resistance and reduced autoregulation of cerebral blood vessels may be important hemodynamic mechanisms of arteriosclerosis-induced cerebral infarction.

  12. Rosiglitazone attenuates transplant arteriosclerosis after allogeneic aorta transplantation in rats

    NARCIS (Netherlands)

    Onuta, Geanina; Rienstra, Heleen; de Boer, Jan Freark; Boer, Mark Walther; Roks, Anton J. M.; Klatter, Flip A.; Uges, Donald R. A.; Navis, Gerjan; Rozing, Jan; Hillebrands, Jan-Luuk

    2007-01-01

    Background. Transplant arteriosclerosis is a leading cause of chronic transplant dysfunction and is characterized by occlusive neointima formation in intragraft arteries. Development of transplant arteriosclerosis is refractory to conventional immunosuppressive drugs and adequate therapy is not avai

  13. Laser Therapy For Arteriosclerosis: Current Review

    Science.gov (United States)

    Dries, David J.; Pollock, Marc E.; Eugene, John

    1987-03-01

    Shortly after the ruby laser was introduced, in 1959, a study for the use of this ruby laser for the in-vitro dissolution of arteriosclerotic plaque was performed.' With subsequent advances in laser technology and with refined delivery techniques, laser applications to the treatment of arteriosclerosis in the coronary arteries and peripheral vascular system is a reality. This report reviews the disease process, arteriosclerosis, and the ef-forts towards laser treatment of this disease. We conclude with a review of the technical barriers to the routine application of laser energy in arteriosclerotic cardiovascular disease and the progress being made to overcome these obstacles.

  14. Work-Related Psychosocial Hazards and Arteriosclerosis.

    Science.gov (United States)

    Chou, Li-Ping; Li, Chung-Yi; Hu, Susan C

    2015-01-01

    The association of psychosocial stress with cardiovascular disease (CVD) is still inconclusive. The aim of this study was to examine the relationships between arteriosclerosis and various work-related conditions among medical employees with various job titles.A total of 576 medical employees of a regional hospital in Taiwan with a mean age of 43 years and female gender dominance (85%) were enrolled. Arteriosclerosis was evaluated by brachial-ankle pulse wave velocity (baPWV). Workrelated conditions included job demands, job control, social support, shift work, work hours, sleep duration, and mental health. The crude relationship between each of the selected covariates and baPWV was indicated by Spearman correlation coefficients. A multiple linear regression model was further employed to estimate the adjusted associations of selected covariates with arteriosclerosis.The mean baPWV of participants was 11.4 ± 2.2 m/s, with the value for males being significantly higher than that for females. The baPWV was associated with gender, age, medical profession, work hours, work type, depression, body mass index, systolic and diastolic blood pressures, fasting glucose, and cholesterol. After being fully adjusted by these factors, only sleep duration of less than 6 hours and weekly work hours longer than 60 hours were significantly associated with increased risk of arteriosclerosis. The conditions of job demands, job control, social support, shift work, and depression showed no significant association with baPWV.Longer work hours and shorter sleep durations were associated with an increased risk of arteriosclerosis. These findings should make it easier for the employer or government to stipulate rational work hours in order to avoid the development of cardiovascular disease among their employees.

  15. Work-Related Psychosocial Hazards and Arteriosclerosis.

    Science.gov (United States)

    Chou, Li-Ping; Li, Chung-Yi; Hu, Susan C

    2015-01-01

    The association of psychosocial stress with cardiovascular disease (CVD) is still inconclusive. The aim of this study was to examine the relationships between arteriosclerosis and various work-related conditions among medical employees with various job titles.A total of 576 medical employees of a regional hospital in Taiwan with a mean age of 43 years and female gender dominance (85%) were enrolled. Arteriosclerosis was evaluated by brachial-ankle pulse wave velocity (baPWV). Workrelated conditions included job demands, job control, social support, shift work, work hours, sleep duration, and mental health. The crude relationship between each of the selected covariates and baPWV was indicated by Spearman correlation coefficients. A multiple linear regression model was further employed to estimate the adjusted associations of selected covariates with arteriosclerosis.The mean baPWV of participants was 11.4 ± 2.2 m/s, with the value for males being significantly higher than that for females. The baPWV was associated with gender, age, medical profession, work hours, work type, depression, body mass index, systolic and diastolic blood pressures, fasting glucose, and cholesterol. After being fully adjusted by these factors, only sleep duration of less than 6 hours and weekly work hours longer than 60 hours were significantly associated with increased risk of arteriosclerosis. The conditions of job demands, job control, social support, shift work, and depression showed no significant association with baPWV.Longer work hours and shorter sleep durations were associated with an increased risk of arteriosclerosis. These findings should make it easier for the employer or government to stipulate rational work hours in order to avoid the development of cardiovascular disease among their employees. PMID:26549394

  16. Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke.

    Science.gov (United States)

    Daniels, S R; Bates, S; Lukin, R R; Benton, C; Third, J; Glueck, C J

    1982-01-01

    The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical status of 8 children who had familial lipoprotein disorders and evidence of thromboembolic cerebrovascular disease. Six of the 8 children had low levels of plasma high density lipoprotein cholesterol, two had high triglyceride levels, and all came from kindreds characterized by familial lipoprotein abnormalities and premature cardio- and/or cerebrovascular atherosclerosis. Vascular occlusion, irregularities of the arterial lumen, beading, tortuosity, and evidence of collateralization were consistently noted. We speculate that cerebrovascular arteriosclerosis in pediatric ischemic stroke victims who have familial lipoprotein abnormalities may be related to lipoprotein-mediated endothelial damage and thrombosis formation, or to the failure to restore endothelial cells' integrity following damage. The apparent association of lipoproteins and strokes in children and their families merits further exploration, particularly when assessing cerebral angiograms in pediatric ischemic stroke victims. In children with unexplained ischemic cerebrovascular accidents, the diagnostic possibility of occlusive arteriosclerosis with thrombosis must be entertained.

  17. Bronchiolitis obliterans organising pneumonia simulating bronchial carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, J.; Flower, C. [Department of Radiology, Addenbrooke`s Hospital, University of Cambridge Teaching Hospital (United Kingdom); Schnyder, P. [Department of Radiology, University Hospital, Lausanne (Switzerland); Herold, C. [Department of Radiology, University Hospital of Vienna (Austria)

    1998-09-01

    Idiopathic bronchiolitis obliterans organising pneumonia (BOOP) is an uncommon but well-recognised condition that usually presents radiologically as bilateral multifocal patchy areas of consolidation on the chest radiograph and on computed tomography (CT). Five cases are described in which the presenting feature was that of a solitary pulmonary nodule. Four of these nodules showed evidence of cavitation and three patients presented with haemoptysis. In all cases the appearances closely resembled bronchial carcinoma. (orig.) With 5 figs., 21 refs.

  18. [Thromboangiitis obliterans (Buerger's disease): update 2015].

    Science.gov (United States)

    Klein-Weigel, Peter; Volz, Theresa Sophie; Richter, Jutta

    2015-10-01

    Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors. PMID:26445249

  19. [Thromboangiitis obliterans (Buerger's disease): update 2015].

    Science.gov (United States)

    Klein-Weigel, Peter; Volz, Theresa Sophie; Richter, Jutta

    2015-10-01

    Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors.

  20. Bronchiolitis Obliterans Organizing Pneumonia Induced by Minocycline

    OpenAIRE

    Shikuwa, Chieko; Kadota, Jun-ichi; Mukae, Hiroshi; Nagata, Towako; Kaida, Hideyuki; Ishii, Hiroshi; Ishimatsu, Yuji; Kohno, Shigeru

    2001-01-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) caused by minocycline (MINO). A 59- year-old man visited to our hospital because of flu-like symptoms. He had been treated with MINO for a few weeks for the skin eruption. The chest radiograph showed consolidations in both lung fields. He was admitted to our hospital for further examination. An elevation of lymphocyte percentage was seen in his bronchoalveolar lavage and a diagnosis of BOOP was confirmed by video-assiste...

  1. Bronchiolitis obliterans from exposure to incinerator fly ash.

    Science.gov (United States)

    Boswell, R T; McCunney, R J

    1995-07-01

    Inhalation of toxic substances in the workplace can result in a variety of respiratory disorders. One relatively rare sequela of the inhalation of toxic fumes is bronchiolitis obliterans, a condition characterized by fibrosis and narrowing of the small airways. Several substances have been reported to cause bronchiolitis obliterans, including ammonia, chlorine, hydrogen fluoride, hydrogen sulfide, nitrogen dioxide, ozone, phosgene, and other irritant fumes. Little has been reported on the pulmonary effects of fly ash produced by the incineration of coal and oil. We report a case of bronchiolitis obliterans with a component of partially reversible airway obstruction in a 39-year-old male occupationally exposed to incinerator fly ash. PMID:7552470

  2. Bronchiolitis Obliterans (BO: HRCT findings in 20 patients

    Directory of Open Access Journals (Sweden)

    Youssriah Yahia Sabri

    2014-03-01

    Conclusion: High-resolution CT is currently superior as an imaging modality in diagnosis of bronchiolitis obliterans, however, diagnosis of BO requires exclusion of other causes of chronic airway obstruction.

  3. Nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia: Report of a case

    OpenAIRE

    Fenton, Mark E; Rani Kanthan; Donald W Cockcroft

    2008-01-01

    Bronchiolitis obliterans organizing pneumonia due to nitrofurantoin has rarely been reported and is associated with poor outcomes. A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented.

  4. Nitrofurantoin-Associated Bronchiolitis Obliterans Organizing Pneumonia: Report of a Case

    Directory of Open Access Journals (Sweden)

    Mark E Fenton

    2008-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia due to nitrofurantoin has rarely been reported and is associated with poor outcomes. A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented.

  5. Cerebral angiographic findings in thromboangiitis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    No, Young J.; Lee, Eun M.; Kim, Jong S. [University of Ulsan, Department of Neurology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea); Lee, Deok H. [University of Ulsan, Department of Neuroradiology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea)

    2005-12-01

    Transient ischemic attacks (TIAs) or ischemic stroke may complicate thromboangiitis obliterans (TAO). However, there has been debate regarding the mechanism of ischemic stroke in TAO. We report the case of a patient with TAO who developed repeated TIAs. An angiogram showed multiple alternative areas of arterial occlusions in the distal segments of both middle cerebral arteries. Extensive collateral vessels around the occluded segment were also observed, which resembled the ''tree root'' or ''corkscrew'' vessels described in the peripheral arteries in TAO. Our patient illustrates that cerebral manifestations of TAO may occur with vascular changes that are identical with those encountered in the limb arteries in TAO. (orig.)

  6. Another Face of Bronchiolitis Obliterans Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    Mark O Turner

    2003-01-01

    Full Text Available A 47-year-old man presented with an eight-day history of nonproductive cough and constitutional symptoms progressing to respiratory failure. High resolution computed tomography revealed a diffuse micronodular pattern and a ‘tree-in-bud’ pattern in the lower lung zones. Transbronchial biopsy showed features consistent with bronchiolitis obliterans organizing pneumonia (BOOP. After an initially difficult clinical course, the patient responded well to long term treatment with corticosteroids, including improvement of air flow obstruction. This case illustrates a variant of BOOP characterized by a comparatively acute onset, a component of proliferative bronchiolitis, an obstructive rather than restrictive pattern of pulmonary function testing and good clinical response to corticosteroid therapy.

  7. Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    E. Vandeix

    2012-01-01

    Full Text Available Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS. A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.

  8. Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation.

    Science.gov (United States)

    Hill, Gary S; Nochy, Dominique; Bruneval, Patrick; Duong van Huyen, J P; Glotz, Denis; Suberbielle, Caroline; Zuber, Julien; Anglicheau, Dany; Empana, Jean-Philippe; Legendre, Christophe; Loupy, Alexandre

    2011-05-01

    In biopsies of renal allografts, arteriosclerosis is often more severe than expected based on the age of the donor, even without a history of rejection vasculitis. To determine whether preformed donor-specific antibodies (DSAs) may contribute to the severity of arteriosclerosis, we examined protocol biopsies from patients with (n=40) or without (n=59) DSA after excluding those with any evidence of vasculitis. Among DSA-positive patients, arteriosclerosis significantly progressed between month 3 and month 12 after transplant (mean Banff cv score 0.65 ± 0.11 to 1.12 ± 0.10, P=0.014); in contrast, among DSA-negative patients, we did not detect a statistically significant progression during the same timeframe (mean Banff cv score 0.65 ± 0.11 to 0.81 ± 0.10, P=not significant). Available biopsies at later time points supported a rate of progression of arteriosclerosis in DSA-negative patients that was approximately one third that in DSA-positive patients. Accelerated arteriosclerosis was significantly associated with peritubular capillary leukocytic infiltration, glomerulitis, subclinical antibody-mediated rejection, and interstitial inflammation. In conclusion, these data support the hypothesis that donor-specific antibodies dramatically accelerate post-transplant progression of arteriosclerosis.

  9. Diagnosis of arteriosclerosis using noninvasive imaging methods

    International Nuclear Information System (INIS)

    The purpose of this study is to evaluate usefulness of X-ray CT, MRI, 2D-echo, and digital subtraction angiography (DSA) in detecting arteriosclerotic changes. Plain and enhanced CT scans were performed on 413 subjects to evaluate aortic sclerosis. CT revealed aortic wall calcification, atheromatous projection of the intima, and thickened aortic walls. These findings appeared frequently with increasing age, and the ratio of atherosclerotic changes to the circumference of the aorta increased in the patients with cerebrovascular disease, coronary heart disease, hypertension, and diabetes. In 179 patients, plain CT and coronary angiography were performed. Sensitivity, specificity, and predictive value for estimating coronary stenosis by CT-detected coronary calcification were 79%, 78%, and 89% respectively. MRI also revealed atherosclerotic changes. In 408 subjects MRI was performed using a spin-echo method. Although atheromatous intimal changes were found in 4.8% of normal subjects, these findings were demonstrated in 46% of the patients with diabetes, in 32% of patients with hypertension, and in 20% of patients with ischemic heart disease. 2D-echo was useful in detecting atheromatous intimal changes in the carotid artery. DSA was also useful for detecting stenosis of the peripheral arteries of median size. In conclusion, these imaging methods can play an important role in diagnosing arteriosclerosis. (author)

  10. Diagnosis of arteriosclerosis using noninvasive imaging methods

    Energy Technology Data Exchange (ETDEWEB)

    Masuda, Yoshiaki; Takasu, Junichiro; Sakakibara, Makoto; Morooka, Nobuhiro; Inagaki, Yoshiaki (Chiba Univ. (Japan). School of Medicine)

    1990-12-01

    The purpose of this study is to evaluate usefulness of X-ray CT, MRI, 2D-echo, and digital subtraction angiography (DSA) in detecting arteriosclerotic changes. Plain and enhanced CT scans were performed on 413 subjects to evaluate aortic sclerosis. CT revealed aortic wall calcification, atheromatous projection of the intima, and thickened aortic walls. These findings appeared frequently with increasing age, and the ratio of atherosclerotic changes to the circumference of the aorta increased in the patients with cerebrovascular disease, coronary heart disease, hypertension, and diabetes. In 179 patients, plain CT and coronary angiography were performed. Sensitivity, specificity, and predictive value for estimating coronary stenosis by CT-detected coronary calcification were 79%, 78%, and 89% respectively. MRI also revealed atherosclerotic changes. In 408 subjects MRI was performed using a spin-echo method. Although atheromatous intimal changes were found in 4.8% of normal subjects, these findings were demonstrated in 46% of the patients with diabetes, in 32% of patients with hypertension, and in 20% of patients with ischemic heart disease. 2D-echo was useful in detecting atheromatous intimal changes in the carotid artery. DSA was also useful for detecting stenosis of the peripheral arteries of median size. In conclusion, these imaging methods can play an important role in diagnosing arteriosclerosis. (author).

  11. Rituximab-Induced Bronchiolitis Obliterans Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    Ahmet B. Ergin

    2012-01-01

    Full Text Available Rituximab-induced lung disease (R-ILD is a rare entity that should be considered in patients treated with rituximab who present with dyspnea, fever, and cough, but no clear evidence of infection. A variety of pathologic findings have been described in this setting. Bronchiolitis obliterans organizing pneumonia (BOOP is the most common clinicopathologic diagnosis, followed by interstitial pneumonitis, acute respiratory distress syndrome (ARDS, and hypersensitivity pneumonitis. Prompt diagnosis and treatment with corticosteroids are essential as discussed by Wagner et al. (2007. Here we present a case of an 82-year-old man who was treated with rituximab for recurrent marginal zone lymphoma. After the first infusion of rituximab, he reported fever, chills, and dyspnea. On computed tomography imaging, he was found to have bilateral patchy infiltrates, consistent with BOOP on biopsy. In our patient, BOOP was caused by single-agent rituximab, in the first week after the first infusion of rituximab. We reviewed the relevant literature to clarify the different presentations and characteristics of R-ILD and raise awareness of this relatively overlooked entity.

  12. Primary sclerosing cholangitis – The arteriosclerosis of the bile duct?

    Directory of Open Access Journals (Sweden)

    Trauner Michael

    2007-01-01

    Full Text Available Abstract Primary sclerosing cholangitis (PSC is a chronic inflammatory disease of unknown aetiology affecting the large bile ducts and characterized by periductal fibrosis and stricture formation, which ultimately result in biliary cirrhosis and liver failure. Arteriosclerosis involves the accumulation of altered lipids and lipoproteins in large arteries; this drives inflammation and fibrosis and ultimately leads to narrowing of the arteries and hypoperfusion of dependent organs and tissues. Knowledge of the causative factors is crucial to the understanding of disease mechanisms and the development of specific treatment. Based on pathogenetic similarities between PSC and arteriosclerosis, we hypothesize that PSC represents "arteriosclerosis of the bile duct" initiated by toxic biliary lipids. This hypothesis is based on common molecular, cellular, and morphological features providing the conceptual framework for a deeper understanding of their pathogenesis. This hypothesis should stimulate translational research to facilitate the search for novel treatment strategies for both diseases.

  13. Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT

    DEFF Research Database (Denmark)

    Holm, A M; Riise, Gerdt; Hansson, Leif Helmuth;

    2013-01-01

    Chronic GVHD (cGVHD) associated bronchiolitis obliterans syndrome (BOS) is a serious complication after allo-SCT, and lung transplantation (LTx) may be the ultimate treatment option. To evaluate this treatment, data on all patients with LTx after allo-SCT ever performed in Sweden, Norway, Denmark...

  14. TCM Treatment of Thromboangiitis Obliterans -A Report of 64 Cases

    Institute of Scientific and Technical Information of China (English)

    门军章; 门九章

    2005-01-01

    @@ Thromboangiitis Obliterans (TAO), a common peripheral vascular disease with a long illness course and grave sufferings, can cause acromelic gangrene, ulcer and even amputation at the late stage. We have for many years used TCM syndrome differentiation to diagnose and treat the disease with good therapeutic results. The treatment of 64 TAO cases from 2001 to 2002 is reported as follows.

  15. Thionyl-chloride-induced lung injury and bronchiolitis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    Konichezky, S.; Schattner, A.; Ezri, T.; Bokenboim, P.; Geva, D. (Kaplan Hospital, Rehovot (Israel))

    1993-09-01

    Thionyl-chloride (TCl) is used in the manufacture of lithium batteries, producing SO2 and HCl fumes on contact with water. We report two cases of accidental TCl exposure resulting in lung injury that may vary from a relatively mild and reversible interstitial lung disease to a severe form of bronchiolitis obliterans causing, after a latent period, an acute/chronic respiratory failure as well as other complications (spontaneous pneumothorax and bronchopleural fistula), previously unreported in TCl fume inhalation.

  16. [Bronchiolitis obliterans with organized pneumonia: apropos 2 new cases].

    Science.gov (United States)

    Fernández Vázquez, E; Zamarrón Sanz, C; Palacios Bartolomé, A; Valle Vázquez, J M; Alvarez Dobaño, J M; Tumbeiro Novoa, M

    1992-12-01

    We present two cases of bronchiolitis obliterans organizing pneumonia (BOOP) with different clinical and radiological characteristics. In one case, the chest X-ray demonstrated bilateral migrating infiltrates. The pathology showed bronchiolar and intra-alveolar occupation by granulation tissue in both cases. It should be noted that both patients responded well to treatment with prednisone although alterations in gas exchange persisted in one case. PMID:1486169

  17. Influence of cerebrovascular arteriosclerosis on cerebral oxygenation during exercise

    International Nuclear Information System (INIS)

    Although it is assumed that cerebral oxygenation during exercise is influenced by both cardiopulmonary function and cerebrovascular arteriosclerosis, the latter factor has not been fully clarified. In the present study the relationship between the degree of cerebrovascular arteriosclerosis and cerebral oxygenation during exercise was investigated. A total of 109 patients (69 patients with coronary artery disease, 40 patients with hypertensive heart disease) (61.7±9.7 years) performed a symptom-limited exercise test with respiratory gas measurements (CPX). From the respiratory gas analysis, peak O2 uptake (VO2), the slope of the increase in VO2 to the increase in work rate (ΔVO2/ΔWR), and the slope of the increase in ventilation to the increase in CO2 output (VE/VCO2 slope) were calculated. Oxyhemoglobin (O2Hb) at the forehead was monitored using near-infrared spectroscopy. The brain ischemic score was counted based upon fluid-attenuated inversion recovery images of magnetic resonance imaging and expressed from 0 to 4. When compared with patients with a lower ischemic score (2Hb during exercise (-1.08±2.7 vs 0.77±4.1 μmol/L, p=0.011). Of brain ischemic score, left ventricular ejection fraction, peak VO2, ΔVO2/ΔWR, and the VE/VCO2 slope, ΔVO2/ΔWR was found to be the sole independent index determining cerebral O2Hb during exercise. The CPX parameters were also significantly related to the degree of cerebrovascular arteriosclerosis. Although cerebral oxygenation during exercise is mainly related to cardiopulmonary function, the degree of cerebrovascular arteriosclerosis partly influences cerebral oxygenation in patients with risk factors for atherosclerosis. (author)

  18. Progenitor cells in arteriosclerosis: good or bad guys?

    Science.gov (United States)

    Campagnolo, Paola; Wong, Mei Mei; Xu, Qingbo

    2011-08-15

    Accumulating evidence indicates that the mobilization and recruitment of circulating or tissue-resident progenitor cells that give rise to endothelial cells (ECs) and smooth muscle cells (SMCs) can participate in atherosclerosis, neointima hyperplasia after arterial injury, and transplant arteriosclerosis. It is believed that endothelial progenitor cells do exist and can repair and rejuvenate the arteries under physiologic conditions; however, they may also contribute to lesion formation by influencing plaque stability in advanced atherosclerotic plaque under specific pathologic conditions. At the same time, smooth muscle progenitors, despite their capacity to expedite lesion formation during restenosis, may serve to promote atherosclerotic plaque stabilization by producing extracellular matrix proteins. This profound evidence provides support to the hypothesis that both endothelial and smooth muscle progenitors may act as a double-edged sword in the pathogenesis of arteriosclerosis. Therefore, the understanding of the regulatory networks that control endothelial and smooth muscle progenitor differentiation is undoubtedly fundamental both for basic research and for improving current therapeutic avenues for atherosclerosis. We update the progress in progenitor cell study related to the development of arteriosclerosis, focusing specifically on the role of progenitor cells in lesion formation and discuss the controversial issues that regard the origins, frequency, and impact of the progenitors in the disease.

  19. Economics of health and mortality special feature: race, infection, and arteriosclerosis in the past.

    Science.gov (United States)

    Costa, Dora L; Helmchen, Lorens A; Wilson, Sven

    2007-08-14

    We document racial trends in chronic conditions among older men between 1910 and 2004. The 1910 black arteriosclerosis rate was six times higher than the white 2004 rate and more than two times higher than the 2004 black rate. We argue that blacks' greater lifelong burden of infection led to high arteriosclerosis rates in 1910. Infectious disease, especially respiratory infections at older ages and rheumatic fever and syphilis at younger ages, predicted arteriosclerosis in 1910, suggesting that arteriosclerosis has an infectious cause. Additional risk factors for arteriosclerosis were being born in the second relative to the fourth quarter, consistent with studies implying that atherogenesis begins in utero, and a low body mass index, consistent with an infectious disease origin of arteriosclerosis.

  20. Radiographic finding in broncholitis obliterans after lung transplantation

    International Nuclear Information System (INIS)

    This paper examines the radiographic findings of bronchiolitis obliterans (BO) after lung transplantation. Among the 55 single- and double-lung transplantations performed at the Toronto General Hospital, 41 have survived longer than 3 months and 7 have developed clinical BO. The chest radiographs, CT scans (where available) and medical records of these 7 patients were reviewed retrospectively, with the use of appropriate controls, and results were correlated with pathologic findings. Pathologic specimens demonstrated widespread BO in 3 patients (open lung biopsy), mild acute rejection with possible BO in 1 (transbronchial biopsy [TBBx]), undefined abnormality with some BO in 1 (TBBx), and acute rejection in 2 (TBBx)

  1. Immune-Mediated Vascular Injury and Dysfunction in Transplant Arteriosclerosis

    Directory of Open Access Journals (Sweden)

    Anna evon Rossum

    2015-01-01

    Full Text Available Solid organ transplantation is the only treatment for end-stage organ failure but this life-saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels within transplanted organs are targeted by the immune system and the resultant vascular damage is a main contributor to acute and chronic graft failure. The vasculature is a unique tissue with specific immunological properties. This review discusses the interactions of the immune system with blood vessels in transplanted organs and how these interactions lead to the development of transplant arteriosclerosis, a leading cause of heart transplant failure.

  2. Performance of long-term CT monitoring in diagnosing bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Berstad, Audun E. [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)]. E-mail: a.e.berstad@medisin.uio.no; Aalokken, Trond Mogens [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Kolbenstvedt, Alf [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Bjortuft, Oystein [Department of Thoracic Medicine, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)

    2006-04-15

    Aim: The purpose of the study was to evaluate the ability of CT, including expiratory scans with minimum intensity projection in predicting the development of bronchiolitis obliterans syndrome after lung transplantation. Materials and methods: Forty consecutive patients, 29 bilateral and 11 single lung transplanted, were followed-up with regular scans for a median of 36 months. Air trapping was evaluated on expiratory scans constructed from two short spiral scans with minimum intensity projection-technique, one at the level of the carina and the other midway between the right diaphragm and the carina. Air trapping was scored on a 16-point scale. Bronchiolitis obliterans syndrome was diagnosed according to established clinical criteria and quantified spirometrically. Results: Bronchiolitis obliterans syndrome developed in 17 patients (43%) after a median of 12 months. Air trapping and bronchiectasis was seen before the diagnosis of bronchiolitis obliterans syndrome in only two and one patient, respectively. Interobserver agreement for air trapping score was good (kappa = 0.65). Air trapping scores performed significantly better than that achieved by chance alone in determining the presence of bronchiolitis obliterans syndrome (P = 0.0025). An air trapping score of 4 or more provided the best results with regard to sensitivity and specificity in diagnosing bronchiolitis obliterans syndrome. The sensitivity, specificity, positive and negative predictive values of an air trapping of 4 or more in the diagnosis of bronchiolitis obliterans syndrome were 77, 74, 68 and 81%, respectively. Conclusion: Expiratory CT scans with minimum intensity projection-reconstruction did not predict the development of bronchiolitis obliterans syndrome in most patients. The findings seriously limit the clinical usefulness of long-term CT monitoring for diagnosing bronchiolitis obliterans syndrome after lung transplantation.

  3. Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.

    Science.gov (United States)

    Wakuda, Hirokazu; Uchida, Shinya; Ikeda, Masahiko; Tabuchi, Masaki; Akahoshi, Yasumitsu; Shinozuka, Kazumasa; Yamada, Shizuo

    2014-01-01

    Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of arteriosclerosis or not. We examined the effects of uric acid and curative drugs for hyperuricemia on atherosclerosis-susceptible C57BL/6J apolipoprotein E-deficient (apoE(-/-)) mice. Male apoE(-/-) mice (age: 6 weeks) were fed a normal diet (normal diet group) or a uric acid-enriched diet. Mice fed the uric acid-enriched diet were divided into three groups and administered a drinking vehicle (high uric acid diet group), allopurinol (20 mg·kg(-1)·d(-1)), or benzbromarone (20 mg·kg(-1)·d(-1)) for 10 weeks. Serum uric acid concentrations were higher in the high uric acid diet group than in the normal diet group, and concentrations in the allopurinol and benzbromarone groups were lower than in the high uric acid diet group. Serum total cholesterol and triglyceride levels were lower in the allopurinol group than in the high uric acid diet group. Oxidative stress was lower in the benzbromarone group than in the high uric acid diet group. Atherosclerotic lesion areas were smaller in the allopurinol and benzbromarone groups than in the high uric acid diet group. Thus, hyperuricemia may not be an independent risk factor for arteriosclerosis; however, the administration of allopurinol and benzbromarone prevented the development of atherosclerosis in apoE(-/-) mice fed a uric acid-enriched diet. The anti-atherosclerotic effect was in part due to lower total cholesterol and oxidative stress in the serum. Other possible mechanisms underlying this effect should be investigated.

  4. Linear opacities on HRCT in bronchiolitis obliterans organising pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, J.M.; Flower, C.D.R. [Dept. of Radiology, Addenbrookes Hospital, Univ. of Cambridge (United Kingdom); Schnyder, P.; Leuenberger, P. [Depts. of Radiology and Medicine, University Hospital, CHUV, Lausanne (Switzerland); Verschakelen, J. [Dept. of Radiology, University Hospital, Leuven (Belgium)

    1999-07-01

    The aim of this study was to report the high-resolution computed tomography (HRCT) appearances of linear opacities that may occur in isolation or in combination with other changes in bronchiolitis obliterans organising pneumonia (BOOP). Eleven patients with BOOP and linear opacities on HRCT were identified at three independent teaching hospitals. The HRCT images and clinical course of each patient were reviewed. Two distinct types of linear opacity were identified. The type-1 opacity extended in a radial manner along the line of the bronchi towards the pleura and was usually intimately related to bronchi. The type-2 opacity occurred in a sub-pleural location and bore no relationship to the bronchi. Both types occurred most commonly in the lower lobes, frequently were associated with multi-focal areas of consolidation and usually completely resolved with treatment. There was no associated bronchiectasis, irreversible volume loss or a reticular or honeycomb pattern. In 2 patients linear opacities were the sole abnormality on HRCT. Bronchiolitis obliterans organising pneumonia may occur in a pure ''linear form'' or HRCT may demonstrate linear opacities in addition to multi-focal consolidation. (orig.)

  5. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells.

    Science.gov (United States)

    Nadig, Satish N; Wieckiewicz, Joanna; Wu, Douglas C; Warnecke, Gregor; Zhang, Wei; Luo, Shiqiao; Schiopu, Alexandru; Taggart, David P; Wood, Kathryn J

    2010-07-01

    Transplant arteriosclerosis is the hallmark of chronic allograft dysfunction (CAD) affecting transplanted organs in the long term. These fibroproliferative lesions lead to neointimal thickening of arteries in all transplanted allografts. Luminal narrowing then leads to graft ischemia and organ demise. To date, there are no known tolerance induction strategies that prevent transplant arteriosclerosis. Therefore, we designed this study to test the hypothesis that human regulatory T cells (T(reg) cells) expanded ex vivo can prevent transplant arteriosclerosis. Here we show the comparative capacity of T(reg) cells, sorted via two separate strategies, to prevent transplant arteriosclerosis in a clinically relevant chimeric humanized mouse system. We found that the in vivo development of transplant arteriosclerosis in human arteries was prevented by treatment of ex vivo-expanded human T(reg) cells. Additionally, we show that T(reg) cells sorted on the basis of low expression of CD127 provide a more potent therapy to conventional T(reg) cells. Our results demonstrate that human T(reg) cells can inhibit transplant arteriosclerosis by impairing effector function and graft infiltration. We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy.

  6. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.

    Science.gov (United States)

    Zhang, Jiqin; Zhou, Huanjiao Jenny; Ji, Weidong; Min, Wang

    2015-05-01

    AIP1 (ASK1-interacting protein-1; encoded by the DAB2IP gene), a signaling scaffolding protein, is abundantly expressed in vascular endothelial cells (EC). While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein). Human genome-wide association study (GWAS) has identified DAB2IP gene variants conferring susceptibility to cardiovascular diseases. Consistently, a global or vascular EC-specific deletion of DAB2IP in mice strongly enhances inflammatory responses and exacerbates atherosclerosis and graft arteriosclerosis progression in mouse models. Mechanisms for AIP1 function and regulation associated with human cardiovascular diseases need further investigations.

  7. A Rare Complication of Spinal Cord Ischemia Following Endovascular Aneurysm Repair of an Infrarenal Abdominal Aortic Aneurysm with Arteriosclerosis Obliterans: Report of a Case

    Science.gov (United States)

    Matsumoto, Takuya; Matsubara, Yutaka; Inoue, Kentaro; Aoyagi, Yukihiko; Matsuda, Daisuke; Tanaka, Shinichi; Okadome, Jun; Maehara, Yoshihiko

    2016-01-01

    We herein report a case of a rare complication of spinal cord ischemia (SCI) following endovascular aneurysm repair (EVAR). Computed tomography showed stenosis and calcification of bilateral iliac arteries and a saccular aneurysm of the terminal aorta. Paraplegia occurred soon after balloon angioplasty of iliac arteries and EVAR. Cerebrospinal fluid drainage was not performed because the patient was on dual antiplatelet drugs. The patient was treated with intravenous methylpredonisolone and naloxone; however, this did not improve his paraplegia. SCI after EVAR is extremely rare and unpredictable complication, however, physicians should be aware of SCI after EVAR in patients with atherosclerosis. PMID:27738476

  8. Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

    Science.gov (United States)

    Cameron, R J; Kolbe, J; Wilsher, M L; Lambie, N

    2000-03-01

    The spectrum of nitrofurantoin lung injury continues to widen. The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury. The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin. Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced. The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP. We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.

  9. Bronchiolitis obliterans organizing pneumonia associated with achalasia: A case report.

    Science.gov (United States)

    Malek, Farhad; Nobakhat, Hossein; Hemmati, Hamidreza

    2016-01-01

    There is little mention in the literature about achalasia as an etiologic factor of Bronchiolitis obliterans organizing pneumonia (BOOP). In this study, a case of BOOP, which appeared to be secondary to achalasia is reported. A 35 years old man present with nonproductive cough, chills and fever from two month ago. Due to permanent consolidation in mid zone of right lung and unresponsive to antibiotics, transthoracic needle biopsy was done that showed BOOP. Due to esophageal dilatation in chest computerized tomography (CT) scan, endoscopy and esophagogram was done that showed achalasia. After surgery and a course of corticosteroid the patient condition became well. This report demonstrates that achalasia may be associated with BOOP. PMID:27408784

  10. Bronchiolitis obliterans organizing pneumonia after irradiation therapy for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kitagawa, Satoshi; Aoshima, Masahiro; Ohmagari, Norio; Tada, Hiroshi; Chohnabayashi, Naohiko; Suzuki, Kohyu [Saint Luke' s International Hospital, Tokyo (Japan)

    2003-02-01

    We report three cases of bronchiolitis obliterans organizing pneumonia (BOOP) that developed after irradiation therapy following breast cancer. All patients presented with cough and fever for 3 to 10 months after the completion of irradiation. Chest radiographs and computed tomography (CT) in all three patients demonstrated a consolidation outside the irradiated fields. Their laboratory data revealed increased C-reactive protein and increased erythrocyte sedimentation rates. Transbronchial lung biopsy was performed in all patients, and plugs of granulation tissue in the bronchioles and interstitial infiltration by mononuclear cells were found. Corticosteroid treatment resulted in rapid clinical improvement. BOOP was diagnosed from the histological and clinical findings. Although the etiology of BOOP still remains unknown, there may be a subgroup of such patients in whom the BOOP is induced by irradiation for breast cancer. These cases were assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  11. Recipient origin of neointimal vascular smooth muscle cells in cardiac allografts with transplant arteriosclerosis

    NARCIS (Netherlands)

    Hillebrands, JL; van den Hurk, BMH; Klatter, FA; Popa, ER; Nieuwenhuis, P; Rozing, J

    2000-01-01

    Background: Coronary artery disease is today's most important post-heart transplantation problem after the first perioperative year. Histologically, coronary artery disease is characterized by transplant arteriosclerosis. The current view on this vasculopathy is that vascular smooth muscle (VSM) cel

  12. Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.

    Science.gov (United States)

    Yamada, Sohsuke; Wang, Ke-Yong; Tanimoto, Akihide; Guo, Xin; Nabeshima, Atsunori; Watanabe, Takeshi; Sasaguri, Yasuyuki

    2013-09-01

    Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC). Recently, we demonstrated that carotid artery-ligated HDC gene-deficient mice (HDC(-/-)) showed less neointimal formation than wild-type (WT) mice, indicating that histamine participates in the process of arteriosclerosis. However, little is known about the roles of histamine-specific receptors (HHRs) in arteriosclerosis. To define the roles of HHRs in arteriosclerosis, we investigated intimal remodeling in ligated carotid arteries of HHR-deficient mice (H1R(-/-) or H2R(-/-)). Quantitative analysis showed that H1R(-/-) mice had significantly less arteriosclerogenesis, whereas H2R(-/-) mice had more, as compared with WT mice. Bone marrow transplantation from H1R(-/-) or H2R(-/-) to WT mice confirmed the above observation. Furthermore, the increased expression of monocyte chemoattractant protein (MCP-1), platelet-derived growth factor (PDGF), adhesion molecules and liver X receptor (LXR)-related inflammatory signaling factors, including Toll-like receptor (TLR3), interleukin-1 receptor (IL-1R) and tumor necrosis factor receptor (TNF-R), was consistent with the arteriosclerotic phenotype of H2R(-/-) mice. Peripheral progenitor cells in H2R(-/-) mice accelerate ligation-induced arteriosclerosis through their regulation of MCP-1, PDGF, adhesion molecules and LXR-related inflammatory signaling factors. In contrast, peripheral progenitor cells act to suppress arteriosclerosis in H1R(-/-) mice, indicating that HHRs reciprocally regulate inflammation in the ligation-induced arteriosclerosis.

  13. Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts.

    Science.gov (United States)

    Eckl, Sebastian; Heim, Christian; Abele-Ohl, Silke; Hoffmann, Julia; Ramsperger-Gleixner, Martina; Weyand, Michael; Ensminger, Stephan M

    2010-09-01

    Our group has shown that platelet inhibition with clopidogrel, an antagonist of the P2Y12 adenosine diphosphate receptor on platelets, reduced the formation of transplant arteriosclerosis. The aim of this study was to investigate whether a combination of cyclosporin or everolimus with clopidogrel has a beneficial effect on the development of transplant arteriosclerosis. Fully MHC mismatched C57Bl/6 (H2(b)) donor aortas were transplanted into CBA.J (H2(k)) recipients and mice received either clopidogrel alone (1 mg/kg/day) or in combination with cyclosporin (2 mg/kg/day) or everolimus (0.05 mg/kg/day). Grafts were analysed by histology and morphometry on day 30 after transplantation. In mice treated with clopidogrel alone, transplant arteriosclerosis was significantly reduced [intima proliferation 56 +/- 11% vs. 81 +/- 7% (control)/n = 7]. Daily application of everolimus reduced the development of transplant arteriosclerosis compared with untreated controls [intima proliferation of 29 +/- 9% vs. 81 +/- 7% (control)/n = 7]. Strikingly, combination of clopidogrel and everolimus almost abolished the formation of transplant arteriosclerosis [intima proliferation: 11 +/- 8% vs. 81 +/- 7% (control)/n = 7]. By contrast, combination of cyclosporin and clopidogrel compared with clopidogrel alone showed no additive effect. These results demonstrate that combination of platelet- and mammalian target of Rapamycin-inhibition can dramatically reduce the development of transplant arteriosclerosis.

  14. Thromboangiitis Obliterans (Buerger’s Disease—Current Practices

    Directory of Open Access Journals (Sweden)

    Abhishek Vijayakumar

    2013-01-01

    Full Text Available Thromboangiitis obliterans (TAO is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40–60% of peripheral vascular diseases. Clinical features and angiographic finding are the basis of early diagnosis of TAO. Abstinence from smoking is the only definitive treatment to prevent disease progression. Medical management in form of aspirin, pentoxyfylline, cilostazol, and verapamil increase pain-free walking distance in intermittent claudication, but long term usage fails to prevent disease progression in patients who continue to smoke. Surgical treatment in form of revascularization, lumbar sympathectomy, omentopexy, and Ilizarov techniques help reduce pain and promote healing of trophic changes. Newer treatment modalities like spinal cord stimulation, prostacyclin, bosentan, VEGF, and stem cell therapy have shown promising results. Latest treatment options include peripheral mononuclear stem cell, and adipose tissue derived mononuclear stem cells have been shown to be effective in preventing disease progression, decrease major amputation rates, and improving quality of life.

  15. Advances in Understanding Bronchiolitis Obliterans After Lung Transplantation.

    Science.gov (United States)

    Verleden, Stijn E; Sacreas, Annelore; Vos, Robin; Vanaudenaerde, Bart M; Verleden, Geert M

    2016-07-01

    Bronchiolitis obliterans syndrome (BOS) remains a major complication after lung transplantation, causing significant morbidity and mortality in a majority of recipients. BOS is believed to be the clinical correlate of chronic allograft dysfunction, and is defined as an obstructive pulmonary function defect in the absence of other identifiable causes, mostly not amenable to treatment. Recently, it has become clear that BOS is not the only form of chronic allograft dysfunction and that other clinical phenotypes exist; however, we focus exclusively on BOS. Radiologic findings typically demonstrate air trapping, mosaic attenuation, and hyperinflation. Pathologic examination reveals obliterative bronchiolitis lesions and a pure obliteration of the small airways (< 2 mm), with a relatively normal surrounding parenchyma. In this review, we highlight recent advances in diagnosis, pathologic examination, and risk factors, such as microbes, viruses, and antibodies. Although the pathophysiological mechanisms remain largely unknown, we review the role of the airway epithelium and inflammation and the various experimental animal models. We also clarify the clinical and therapeutic implications of these findings. Although significant progress has been made, the exact pathophysiological mechanisms and adequate therapy for posttransplantation BOS remain unknown, highlighting the need for further research to improve long-term posttransplantation BOS-free and overall survival. PMID:27212132

  16. Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans.

    Science.gov (United States)

    Tanou, Kalliopi; Xaidara, Athina; Kaditis, Athanasios G

    2015-05-01

    Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans. PMID:25682945

  17. Study on the classification algorithm of degree of arteriosclerosis based on fuzzy pattern recognition

    Science.gov (United States)

    Ding, Li; Zhou, Runjing; Liu, Guiying

    2010-08-01

    Pulse wave of human body contains large amount of physiological and pathological information, so the degree of arteriosclerosis classification algorithm is study based on fuzzy pattern recognition in this paper. Taking the human's pulse wave as the research object, we can extract the characteristic of time and frequency domain of pulse signal, and select the parameters with a better clustering effect for arteriosclerosis identification. Moreover, the validity of characteristic parameters is verified by fuzzy ISODATA clustering method (FISOCM). Finally, fuzzy pattern recognition system can quantitatively distinguish the degree of arteriosclerosis with patients. By testing the 50 samples in the built pulse database, the experimental result shows that the algorithm is practical and achieves a good classification recognition result.

  18. Bronchiolitis obliterans after allogenic bone marrow transplantation: HRCT findings

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jung Im; Jung, Won Sang; Hahn, Seong Tai; Park, Seog Hee [St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of); Min, Chang Ki; Kim, Chun Choo [College of Medicine, The Catholic University, Seoul (Korea, Republic of)

    2004-06-15

    To evaluate the high resolution computed tomography (HRCT) findings of bronchiolitis obliterans (BO) after bone marrow transplantation (BMT). During the past three years, 11 patients were diagnosed as having BO after BMT when they developed irreversible air flow obstruction, with an FEV{sub 1} value of less than 80% of the baseline value, without any clinical evidence of infection. All 11 patients underwent HRCT, of whom eight also underwent follow-up HRCT. The HRCT images were assessed retrospectively for the presence of decreased lung attenuation, segmental or subsegmental bronchial dilatation, diminution of peripheral vascularity, centrilobular nodules, and branching linear structure on the inspiratory images. The lobar distribution of the decreased lung attenuation and bronchial dilatation was also examined. The presence of air trapping was investigated on the expiratory images. The interval changes of the HRCT findings were evaluated in those patients who had follow-up images. Abnormal HRCT findings were present in all cases; the most common abnormalities were decreased lung attenuation (n=11), subsegmental bronchial dilatation (n=6), diminution of peripheral vascularity (n=6), centrilobular nodules or branching linear structure (n=3), and segmental bronchial dilatation (n=3). Expiratory air trapping was noted in all patients. The decreased lung attenuation and bronchial dilatations were more frequent or extensive in the lower lobes. Interval changes were found in all patients with follow-up HRCT: increased extent of decreased lung attenuation (n=7); newly developed or progressed bronchial dilatation (n=4); and increased lung volume (n=3). HRCT scans are abnormal in patients with BO, with the most commonly observed finding being areas of decreased lung attenuation. While the HRCT findings are not specific, it is believed that their common features can assist in the diagnosis of BO in BMT recipients.

  19. Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

    DEFF Research Database (Denmark)

    Uhlving, H H; Buchvald, F; Heilmann, C J;

    2012-01-01

    Bronchiolitis obliterans (BO) following allogeneic haematopoietic SCT (HSCT) is a serious complication affecting 1.7-26% of the patients, with a reported mortality rate of 21-100%. It is considered a manifestation of chronic graft-versus-host disease, but our knowledge of aetiology and pathogenesis...

  20. Diffuse micronodular pattern of bronchiolitis obliterans organizing pneumonia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, In Jae; Jang, Seung Hun; Min, Kwang Seon; Whang, Im Kyung; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang (Korea, Republic of)

    2006-10-15

    The typical radiographic findings of bronchiolitis obliterans organizing pneumonia (BOOP) are known to be patchy air-space consolidation that is often subpleural, and with or without ground-glass opacities. However, there are scant radiologic reports about the micronodular pattern of BOOP. We report here on a case of BOOP that manifested as diffusely scattered ill-defined centrilobular micronodules on HRCT.

  1. Multiple complications due to osteoradionecrosis in a patient with thromboangiitis obliterans.

    NARCIS (Netherlands)

    Barkhuysen, R.; Janssens, G.O.; Wilde, P.C.M. de; Merkx, M.A.W.

    2007-01-01

    A case is presented of a patient with thromboangiitis obliterans (TAO) who developed severe necrosis of the intraoral soft tissues and maxillary and mandibular bone after radiotherapy for a cT2N0M0 squamous cell carcinoma of the soft palate. Multiple surgical procedures including partial resection o

  2. Biomarkers for the prediction of the bronchiolitis obliterans syndrome after lung transplantation

    NARCIS (Netherlands)

    Paantjens, A.W.M.

    2011-01-01

    The main limitation for overall survival after lung transplantation (LTx) is the development of chronic rejection, which is represented by the bronchiolitis obliterans syndrome (BOS). The diagnosis BOS is based on lung function testing, however, it is a surrogate marker. And because BOS is an irreve

  3. Pulmonary Rehabilitation for Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation

    OpenAIRE

    Tran, Jerry; Norder, Emily; Diaz, Phil; Gary S Phillips; Elder, Pat; Devine, Steven M; Wood, Karen L.

    2012-01-01

    Bronchiolitis obliterans syndrome (BOS) is a progressive, insidious lung disease affecting allogeneic hematopoietic stem cell transplant (HSCT) recipients. Unfortunately, there is no standardized approach for treatment of BOS in post HSCT patients. Pulmonary rehabilitation is a standard treatment in emphysema, an irreversible obstructive lung disease secondary to tobacco abuse. The National Emphysema Treatment Trial (NETT) demonstrated improved exercise tolerance, decrease dyspnea, and increa...

  4. Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1α.

    Science.gov (United States)

    Li, J; Liu, S; Li, W; Hu, S; Xiong, J; Shu, X; Hu, Q; Zheng, Q; Song, Z

    2012-08-01

    Transplant arteriosclerosis is a leading cause of late allograft loss. Medial smooth muscle cell (SMC) apoptosis is considered to be an important event in transplant arteriosclerosis. However, the precise contribution of medial SMC apoptosis to transplant arteriosclerosis and the underlying mechanisms remain unclear. We transferred wild-type p53 to induce apoptosis of cultured SMCs. We found that apoptosis induces the production of SDF-1α from apoptotic and neighboring viable cells, resulting in increased SDF-1α in the culture media. Conditioned media from Ltv-p53-transferred SMCs activated PI3K/Akt/mTOR and MAPK/Erk signaling in a SDF-1α-dependent manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation. In a rat aorta transplantation model, lentivirus-mediated BclxL transfer selectively inhibits medial SMC apoptosis in aortic allografts, resulting in a remarkable decrease of SDF-1α both in allograft media and in blood plasma, associated with diminished recruitment of CD90(+)CD105(+) double-positive cells and impaired neointimal formation. Systemic administration of rapamycin or PD98059 also attenuated MSC recruitment and neointimal formation in the aortic allografts. These results suggest that medial SMC apoptosis is critical for the development of transplant arteriosclerosis through inducing SDF-1α production and that MSC recruitment represents a major component of vascular remodeling, constituting a relevant target and mechanism for therapeutic interventions.

  5. Experimental coronary sclerosis induced by immobilization of rabbits: A new model of arteriosclerosis

    Science.gov (United States)

    Tyavokin, V. V.; Tjawokin, W. W.

    1980-01-01

    A new method for producing arteriosclerosis with coronary insufficiency in rabbits by means of immobilization is described and discussed. The experimentally induced atherosclerosis develops due to hypodynamics imposed by the reduced muscular activity without overloading with exogenous cholesterol. The atherosclerosis and coronary insufficiency are associated. With variations in the duration and extent of immobilization, coronary insufficiency alone or with atherosclerosis can be produced.

  6. Investigation of the Etiology of Anemia in Thromboangiitis Obliterans.

    Science.gov (United States)

    Akbarin, Mohammad Mehdi; Ravari, Hassan; Rajabnejad, Ataollah; Valizadeh, Narges; Fazeli, Bahare

    2016-09-01

    During a review of patients admitted with thromboangiitis obliterans (TAO), there was evidence of normochromic normocytic anemia and abrupt changes in hemoglobin (Hgb) levels in patients with several hospital admissions. Therefore, the evidence of hemolytic anemia was evaluated based on 37 banked plasma samples taken from Caucasian male TAO patients during disease exacerbation between 2012 and 2014. The patients' hospital records, including clinical manifestations and complete blood count, were evaluated. The following tests were performed on all samples: indirect antiglobulin test (IAT), C-reactive protein (CRP), high-sensitivity CRP (hsCRP), lactate dehydrogenase (LDH), haptoglobin, indirect bilirubin, d-aspartate aminotransferase (AST), and d-alanine aminotransferase (ALT). The mean age of the patients was 40 ± 7 years. Two patients underwent below-knee amputation. The mean hospital-documented Hgb of the patients was 12.9 ± 2.6 g/dL. CRP and IAT were positive in 75.6 and 70.2% of the samples, respectively. The tests and corresponding results were as follows: hsCRP, 14.07 ± 2.37 µg/mL; LDH, 2,552 ± 315 u/L; haptoglobin, 2.27 ± 1.1 g/L; indirect bilirubin, 0.09 ± 0.04 mg/dL; AST, 67 ± 7 u/L; and ALT, 26 ± 3 u/L. There was a significant inverse correlation between hsCRP and hospital-documented Hgb level (p = 0.03). Anemia with the positive IAT in most of the samples, high LDH and AST, and normal ALT are suggestive of hemolytic anemia. Normal indirect bilirubin is consistent with intravascular hemolysis. The positive CRP and elevated haptoglobin levels could be due to systemic inflammation in TAO. However, it is not known if an autoantigen or an infectious antigen is responsible for TAO systemic inflammation and induction hemolytic anemia. As such, the underlying mechanism of anemia in TAO could be part of the footprint of its main etiology. PMID:27574381

  7. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation

    OpenAIRE

    Corris, Paul A; Ryan, Victoria A; Small, Therese; Lordan, James; Fisher, Andrew J.; Meachery, Gerard; Johnson, Gail; Ward, Chris

    2015-01-01

    Background We conducted a placebo-controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. Methods We compared azithromycin (250 mg alternate days, 12 weeks) with placebo. Primary outcome was FEV1 change at 12 weeks. Results 48 patients were randomised; (25 azithromycin, 23 placebo). It was established, post randomisation that two did not have BOS. 46 patients were analysed as intention to treat (ITT) with 33 ‘Completers’. ITT analysis inc...

  8. Rapamycin Blocks Fibrocyte Migration and Attenuates Bronchiolitis Obliterans in a Murine Model

    Science.gov (United States)

    Gillen, Jacob R.; Zhao, Yunge; Harris, David A.; LaPar, Damien J.; Stone, Matthew L.; Fernandez, Lucas G.; Kron, Irving L.; Lau, Christine L.

    2014-01-01

    Background Fibrocytes are integral in the development of fibroproliferative disease. The CXCL12/CXCR4 chemokine axis has been shown to play a central role in fibrocyte migration and the development of bronchiolitis obliterans post lung transplantation. Inhibition of the mTOR (mammalian target of rapamycin) pathway with rapamycin has been shown to decrease expression of both CXCR4 and its receptor agonist, CXCL12. Thus, we hypothesize that rapamycin treatment would decrease fibrocyte trafficking into tracheal allografts and prevent bronchiolitis obliterans. Methods A total alloantigenic mismatch, murine heterotopic tracheal transplant model of bronchiolitis obliterans was used. Animals were either treated with rapamycin or dimethyl sulfoxide (DMSO) for 14 days post tracheal transplant. Fibrocyte levels were assessed via flow cytometry, and allograft neutrophil, CD3+ T-cell, macrophage, and smooth muscle actin levels were assessed via immunohistochemistry. Tracheal luminal obliteration was assessed on hematoxylin and eosin stains. Results Compared to DMSO controls, rapamycin-treated mice showed a significant decrease in fibrocyte levels in tracheal allografts. Fibrocytes levels in recipient’s blood showed a similar pattern, although not statistically significant. Furthermore, animals treated with rapamycin showed a significant decrease in tracheal allograft luminal obliteration compared to controls. Based on immunohistochemistry analyses, populations of α-SMA positive cells, neutrophils, CD3+ T-cells, and macrophages were all decreased in rapamycin-treated allograft versus DMSO controls. Conclusions Rapamycin effectively reduces recruitment of fibrocytes into tracheal allografts and mitigates development of tracheal luminal fibrosis. Further studies are needed to determine the cellular and molecular mechanisms that mediate the protective effect of rapamycin against bronchiolitis obliterans. PMID:23561805

  9. Bronchiolitis obliterans organizing pneumonia after tangential beam irradiation to the breast. Discrimination from radiation pneumonitis

    Energy Technology Data Exchange (ETDEWEB)

    Nambu, Atsushi; Ozawa, Katsura; Kanazawa, Masaki; Miyata, Kazuyuki [Kofu Municipal Hospital (Japan); Araki, Tsutomu; Ohki, Zennosuke [Yamanashi Medical Coll., Tamaho (Japan)

    2002-06-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) secondary to tangential beam irradiation to the breast, which occurred seven months after the completion of radiotherapy. Although radiation pneumonitis is an alternative consideration, BOOP could be differentiated from it by its relatively late onset and extensive distribution, which did not respect the radiation field. This disease should always be kept in mind in patients with a history of tangential beam irradiation to the breast. (author)

  10. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    OpenAIRE

    Hamidun Bunawan; Siti Noraini Bunawan; Syarul Nataqain Baharum; Normah Mohd Noor

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indon...

  11. Increased Respiratory Disease Mortality at a Microwave Popcorn Production Facility with Worker Risk of Bronchiolitis Obliterans

    OpenAIRE

    Halldin, Cara N; Eva Suarthana; Kathleen B Fedan; Yi-Chun Lo; George Turabelidze; Kathleen Kreiss

    2013-01-01

    BACKGROUND: Bronchiolitis obliterans, an irreversible lung disease, was first associated with inhalation of butter flavorings (diacetyl) in workers at a microwave popcorn company. Excess rates of lung-function abnormalities were related to cumulative diacetyl exposure. Because information on potential excess mortality would support development of permissible exposure limits for diacetyl, we investigated respiratory-associated mortality during 2000-2011 among current and former workers at this...

  12. Polyarteritis Nodosa and Bronchiolitis Obliterans with Organizing Pneumonia, an Unusual Association

    OpenAIRE

    Kaberi Dasgupta; A Kevin Watters; Arnold Zidulka

    1997-01-01

    Bronchiolitis obliterans and organizing pneumonia (BOOP) is an inflammatory, fibrotic disorder of the small airways, alveoli and pulmonary intersitium. Often idiopathic and usually benign, this condition may cause dyspnea and influenza-like symptoms. Polyarteritis nodosa (PAN) is a small and medium vessel vasculitis, which usually involves the kidney and other viscera but rarely results in vasculitis of the lungs. This is the second case of BOOP associated with PAN reported in the literature....

  13. Are we near to an effective drug treatment for bronchiolitis obliterans?

    OpenAIRE

    Verleden, Geert; Vos, Robin; Dupont, Lieven; Van Raemdonck, Dirk; Vanaudenaerde, Bart; Verleden, Stijn

    2014-01-01

    Lung transplantation remains the only effective therapeutic option for well-selected patients with end-stage (cardio) pulmonary diseases such as emphysema, cystic fibrosis, lung fibrosis and pulmonary arterial hypertension. Although the results have improved lately, the long-term survival is still far behind other organ transplantations. This is mainly due to the development of chronic lung allograft dysfunction (CLAD), with bronchiolitis obliterans (BO) being the most frequent manifestation ...

  14. Ventilation/Perfusion Scintigraphy in Children with Post-Infectious Bronchiolitis Obliterans: A Pilot Study

    OpenAIRE

    Xie, Bo-Qia; Wang, Wei; Zhang, Wen-Qian; Guo, Xin-Hua; Yang, Min-Fu; Wang, Li; He, Zuo-Xiang; Tian, Yue-Qin

    2014-01-01

    Purpose Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few retrospective researches investigating post-infectious BO involved V/Q scan, the clinical value of this method is unknown. This preliminary prospective study was aimed to evaluate the correlation of V/Q scan with disease...

  15. Effects of a healthy life exercise program on arteriosclerosis adhesion molecules in elderly obese women

    OpenAIRE

    Lim, Seung-Taek; Min, Seok-Ki; Park, Hyuntae; Park, Jong-Hwan; Park, Jin-Kee

    2015-01-01

    [Purpose] The aim of this study was to investigate the change in the arteriosclerosis adhesion molecules after a healthy life exercise program that included aerobic training, anaerobic training, and traditional Korean dance. [Subjects] The subjects were 20 elderly women who were over 65 years of age and had 30% body fat. [Methods] The experimental group underwent a 12-week healthy life exercise program. To evaluate the effects of the healthy life exercise program, measurements were performed ...

  16. Coronary arterial Disease associated with arteriosclerosis in lower extremity: Angiographic analysis

    International Nuclear Information System (INIS)

    We performed both peripheral and coronary angiographies in 52 patients with an arteriosclerosis in lower extremities. The severity of arteriosclerotic narrowing of the coronary and peripheral arteries were compared on angiographies. An angiographic vascular score(AVS, 0-5) reflecting the number and the degree of stenosis in 12 lower extremity arteries and three major coronary arteries was assigned to each angiogram and the sun of scores in the lower extremity arteries was compared with the incidence of significant coronary artery disease (more than grade 3) and coronary score. Relation of incidence and severity of vascular stenosis and risk factors (diabetes metallitus, hypertension, smoking, and hypercholesterolemia) was also analyzed. Thirty-four of 52 patients (65%) had an angiographically significant coronary artery disease. Thirteen of these 34 patients (38%) had no clinical symptom and sign of the ischemic heart disease. There was no statistically significant difference in the incidence and severity of coronary artery disease between high (more than 30) and low AVS group in lower extremity (p>0.14). All patients had at least one risk factor and 49 of 52 patients (94%) had multiple risk factors. Coronary angiography was normal in there patients with only one risk factors, and angiographically significant coronary artery disease existed in nine of 16 cases (56.3%) with two risk factors. 13 of 17 case (76.5%) with three risk factors, and 12 of 16 cases (75.0%) with all four risk factors. There were no significant correlations between individual risk factors and incidence, severity of arteriosclerosis in coronary and lower extremity arteries. In conclusion, angiographic evaluation of the coronary artery disease in patients with lower extremity arteriosclerosis is necessary because of the high chance of coronary artery disease and difficulty in the prediction of coronary artery disease with a severity of the peripheral arteriosclerosis, presence of various risk

  17. The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots

    OpenAIRE

    Jovelić Aleksandra; Rađen Slavica; Hajduković Zoran; Čanji Tibor

    2009-01-01

    Background/Aim. Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP) and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pil...

  18. C-peptide promotes lesion development in a mouse model of arteriosclerosis.

    Science.gov (United States)

    Vasic, Dusica; Marx, Nikolaus; Sukhova, Galina; Bach, Helga; Durst, Renate; Grüb, Miriam; Hausauer, Angelina; Hombach, Vinzenz; Rottbauer, Wolfgang; Walcher, Daniel

    2012-04-01

    Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show elevated serum levels of the proinsulin cleavage product C-peptide and immunohistochemical data from our group revealed C-peptide deposition in early lesions of these individuals. Moreover, in vitro studies suggest that C-peptide could promote atherogenesis. This study examined whether C-peptide promotes vascular inflammation and lesion development in a mouse model of arteriosclerosis. ApoE-deficient mice on a high fat diet were treated with C-peptide or control injections for 12 weeks and the effect on lesion size and plaque composition was analysed. C-peptide treatment significantly increased C-peptide blood levels by 4.8-fold without having an effect on glucose or insulin levels, nor on the lipid profile. In these mice, C-peptide deposition in atherosclerotic plaques was significantly increased compared with controls. Moreover, lesions of C-peptide-treated mice contained significantly more macrophages (1.6 ± 0.3% versus 0.7 ± 0.2% positive area; P arteriosclerosis support the hypothesis that C-peptide may have an active role in atherogenesis in patients with diabetes and insulin resistance.

  19. Radiographic manifestations of Mönckeberg arteriosclerosis in the head and neck region

    Energy Technology Data Exchange (ETDEWEB)

    Tahmasbi-Arashlow, Mehrnaz; Barghan, Sevin; Kashtwari, Beeba; Nair, Madhu K. [Oral and Maxillofacial Radiology, Colleges of Dentistry and Medicine, University of Florida, Gainesville (United States)

    2016-03-15

    Mönckeberg sclerosis is a disease of unknown etiology, characterized by dystrophic calcification within the arterial tunica media of the lower extremities leading to reduced arterial compliance. Medial calcinosis does not obstruct the lumina of the arteries, and therefore does not lead to symptoms or signs of limb or organ ischemia. Mönckeberg sclerosis most commonly occurs in aged and diabetic individuals and in patients on dialysis. Mönckeberg arteriosclerosis is frequently observed in the visceral arteries, and it can occur in the head and neck region as well. This report describes a remarkable case of Mönckeberg arteriosclerosis in the head and neck region as detected on dental imaging studies. To the best of our knowledge, this is the first case that has been reported in which this condition presented in the facial vasculature. The aim of this report was to define the radiographic characteristics of Mönckeberg arteriosclerosis in an effort to assist health care providers in diagnosing and managing this condition.

  20. Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

    Directory of Open Access Journals (Sweden)

    Rafaela C.S. De Paula

    2014-12-01

    General significance: In the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries.

  1. 小儿闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    陈强

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,是一种相对少见而严重的慢性阻塞性肺病.其主要临床特点是反复或持续气促、喘息或咳嗽,运动耐力差,肺部有细湿啰音和喘鸣音,对支气管扩张剂无反应[1].

  2. Bronchiolitis obliterans organizing pneumonia after adjuvant thoracic radiotherapy for breast cancer. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Katsuyasu; Ogasawara, Tomohiko; Akita, Yuko; Miyazaki, Mikinori; Inukai, Akihiro; Shinjo, Keiko; Suzuki, Masayuki [Nagoya Daini Red Cross Hospital (Japan)

    2001-02-01

    We report a case of recurrent cough and migratory pulmonary infiltrates in a 55-year-old woman after adjuvant thoracic radiotherapy for breast cancer. The pulmonary infiltrates were initially limited to the area adjacent to the irradiated breast, but later migrated to the opposite lung. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was made using transbronchial biopsy, which disclosed intraluminal fibrosis in the distal airspace, together with a radiographic appearance typical of BOOP. This case was assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  3. Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?

    Science.gov (United States)

    Madill, Janet; Aghdassi, Ellie; Arendt, Bianca; Hartman-Craven, Brenda; Gutierrez, Carlos; Chow, Chung-Wai; Allard, Johane

    2009-04-01

    Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS. PMID:19298941

  4. Polyarteritis Nodosa and Bronchiolitis Obliterans with Organizing Pneumonia, an Unusual Association

    Directory of Open Access Journals (Sweden)

    Kaberi Dasgupta

    1997-01-01

    Full Text Available Bronchiolitis obliterans and organizing pneumonia (BOOP is an inflammatory, fibrotic disorder of the small airways, alveoli and pulmonary intersitium. Often idiopathic and usually benign, this condition may cause dyspnea and influenza-like symptoms. Polyarteritis nodosa (PAN is a small and medium vessel vasculitis, which usually involves the kidney and other viscera but rarely results in vasculitis of the lungs. This is the second case of BOOP associated with PAN reported in the literature. Knowledge of this association is likely to be of value because an undiagnosed vasculitis can rapidly become fatal.

  5. Bronchiolitis obliterans organizing pneumonia after radiation therapy for lung cancer: a case report.

    Science.gov (United States)

    Falcinelli, Lorenzo; Bellavita, Rita; Rebonato, Alberto; Chiari, Rita; Vannucci, Jacopo; Puma, Francesco; Aristei, Cynthia

    2015-01-01

    Bronchiolitis obliterans organizing pneumonia (BOOP), also known as cryptogenic organizing pneumonia, has mainly been described in patients with breast cancer who received radiotherapy after breast-conserving surgery. In this rare case, a 70-year-old man with left apical squamous lung cancer developed BOOP after radiotherapy and only one cycle of concomitant chemotherapy.This case report draws attention to the development of this syndrome in the unusual setting of lung cancer, advising prompt steroid treatment when diagnostic images reveal the characteristic signs of the disease. PMID:25908030

  6. Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma

    International Nuclear Information System (INIS)

    Common complications of thoracic radiotherapy include esophagitis and radiation pneumonitis. However, it is important to be aware of uncommon post-radiotherapy complications such as bronchiolitis obliterans organizing pneumonia (BOOP). We report on two patients with carcinoma of the breast who developed an interstitial lung disease consistent with BOOP. BOOP responds to treatment with corticosteroids and the prognosis is generally good despite of the need for long-term administration of corticosteroids as relapses can occur during tapering of steroids. This report provides guidelines for the evaluation and treatment of patients with pulmonary infiltrates after radiotherapy

  7. Correlation Between Arteriosclerosis and Periodontal Condition Assessed by Lactoferrin and α1-Antitrypsin Levels in Gingival Crevicular Fluid.

    Science.gov (United States)

    Hayashi, Shuji; Yamada, Hirotsugu; Fukui, Makoto; Ito, Hiro-o; Sata, Masataka

    2015-01-01

    Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment of periodontal disease been proven to prevent atherosclerotic vascular disease. Therefore, the aim of the present study was to examine the correlation between periodontal condition and arteriosclerosis in patients with coronary artery disease (CAD), which is usually accompanied by systemic arteriosclerosis.We measured levels of gingival crevicular fluid lactoferrin (GCF-Lf) and α1-antitrypsin (GCF-AT) in 72 patients (67 ± 8 years, 56 men) with CAD. Furthermore, we evaluated the maximum intima-media thickness (max IMT) and plaque score of the carotid arteries as well as brachial-ankle pulse wave velocity (baPWV) and flow-mediated dilation (FMD) of the brachial artery, each of which is a parameter for determining arteriosclerosis status. The average level of GCF-Lf was 0.29 ± 0.36 µg/mL and that of GCF-AT was 0.31 ± 0.66 µg/mL, with significant correlation between the two (r = 0.701, P arteriosclerosis parameters (ie, max IMT, plaque score, baPWV, and FMD) and GCF-Lf or GCF-AT.No correlation between the GCF biomarkers and the severity of arteriosclerosis was detected. This result may suggest that worsening of the periodontal condition assessed by GCF biomarkers is not a major potential risk factor for arteriosclerosis.

  8. Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.;

    2009-01-01

    BACKGROUND: Post-transplant baseline forced expiratory volume in 1 second (FEV(1)) constitutes a systematic bias in analyses of bronchiolitis obliterans syndrome (BOS). This retrospective study evaluates risk factors for BOS adjusting for the confounding of post-transplant baseline FEV(1). METHODS...

  9. Unaltered levels of transplant arteriosclerosis in the absence of the B cell homing chemokine receptor CXCR5.

    Science.gov (United States)

    Ensminger, Stephan M; Abele-Ohl, Silke; Ohl, Lars; Spriewald, Bernd M; Ramsperger-Gleixner, Martina; Weyand, Michael; Förster, Reinhold

    2009-03-01

    Chemokine receptors and their ligands are crucial for lymphocyte trafficking under both homeostatic and inflammatory conditions. The chemokine receptor CXCR5 controls B cell migration and the organization of B cell follicles. The aim of this study was to investigate the impact of CXCR5 on the development of transplant arteriosclerosis. Fully MHC mismatched BALB/c (H2(d)) donor aortas were transplanted into C57BL/6-CXCR5(-/-) (H2(b)), C57BL/6-CXCR5(+/-) (H2(b)) or C57BL/6-CXCR5(+/+) (H2(b)) recipients. Grafts were analysed by morphometry and immunofluorescence and intra-graft cytokine mRNA production was analysed by RT-PCR. Transplant arteriosclerosis was evident in CXCR5+/+ and CXCR5+/- mice and only mildly reduced in CXCR5-/- recipients indicating that absence of CXCR5 had no substantial effect on the development of transplant arteriosclerosis. Analysis of the cellular infiltrate of aortic grafts implanted in CXCR5-/- recipients revealed no differences in the number of T-cells, macrophages and B cells as compared to controls. Intra-graft cytokine production showed no significant changes in Th1 (IL-12) and Th2 (IL-4) cytokines as well as in TGF-beta and iNOS production. These data suggest that lack of CXCR5 expression by recipient T- and B-cells has little effect on the development of transplant arteriosclerosis.

  10. Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.

    Science.gov (United States)

    Ghandourah, Hasan; Bhandal, Samarjeet; Brundler, Marie-Anne; Noseworthy, Mary

    2016-01-01

    A 14-year-old girl who was known to have a seizure disorder and on lamotrigine treatment was admitted to the hospital, with a history of rash, fever and cough. Her condition deteriorated with clinical features suggestive of anticonvulsant hypersensitivity syndrome (ACHS) complicated with bronchiolitis obliterans organising pneumonia (BOOP). Her chest CT showed multifocal parenchymal opacities and lung biopsy was typical for BOOP. Initially, the lamotrigine was discontinued since the onset of the rash, then she was treated for pneumonia with antibiotics, which may have delayed the diagnosis. Eventually, BOOP was considered and she was treated with a high dose of corticosteroid. She improved clinically and her repeated chest CT showed a marked resolution of the lesions. This case illustrates the possible occurrence of BOOP as a complication of ACHS secondary to lamotrigine treatment. PMID:26825933

  11. Successful treatment of Bronchiolitis obliterans with organizing pneumonia in dialysis patient

    Directory of Open Access Journals (Sweden)

    Vivek B Kute

    2012-01-01

    Full Text Available A 42-year-old end stage renal disease (ESRD patient was admitted with fever, anorexia, malaise, non-productive cough, and dyspnea, of one-week duration. Multiple cultures of the blood, sputum, and urine were negative for microorganisms. The possibility of bronchiolitis obliterans with organizing pneumonia (BOOP was considered when patient with pulmonary infiltrate did not respond to conventional antibiotic therapy and frequent hemodyalisis. High-resolution computed tomography of the chest revealed patchy air-space consolidation, ground-glass opacities, and small nodular opacities, predominantly located at the peripheral part of the lungs. Cultures and stains of bronchoalveolar lavage (BAL specimen and bronchoscopic biopsy of lung tissue were negative for organisms [bacteria, mycobacterium tuberculosis, PCP, fungus, and atypical organism] and showed evidence of BOOP. Patient recovered completely with early diagnosis and treatment with steroids and underwent successful renal transplantation with wife as donor without postoperative complication and relapse.

  12. Biopsy-verified bronchiolitis obliterans and other noninfectious lung pathologies after allogeneic hematopoietic stem cell transplantation

    DEFF Research Database (Denmark)

    Uhlving, Hilde Hylland; Andersen, Claus B; Christensen, Ib Jarle;

    2015-01-01

    Bronchiolitis obliterans (BO) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Lung biopsy is the gold standard for diagnosis. This study describes the course of BO and assesses the congruity between biopsy-verified BO and a modified version of the National...... Institutes of Health's consensus criteria for BO syndrome (BOS) based exclusively on noninvasive measures. We included 44 patients transplanted between 2000 and 2010 who underwent lung biopsy for suspected BO. Of those, 23 were diagnosed with BO and 21 presented other noninfectious pulmonary pathologies......, such as cryptogenic organizing pneumonia, diffuse alveolar damage, interstitial pneumonia, and nonspecific interstitial fibrosis. Compared with patients with other noninfectious pulmonary pathologies, BO patients had significantly lower values of forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity...

  13. Mouse model of alloimmune-induced vascular rejection and transplant arteriosclerosis.

    Science.gov (United States)

    Enns, Winnie; von Rossum, Anna; Choy, Jonathan

    2015-05-17

    Vascular rejection that leads to transplant arteriosclerosis (TA) is the leading representation of chronic heart transplant failure. In TA, the immune system of the recipient causes damage of the arterial wall and dysfunction of endothelial cells and smooth muscle cells. This triggers a pathological repair response that is characterized by intimal thickening and luminal occlusion. Understanding the mechanisms by which the immune system causes vasculature rejection and TA may inform the development of novel ways to manage graft failure. Here, we describe a mouse aortic interposition model that can be used to study the pathogenic mechanisms of vascular rejection and TA. The model involves grafting of an aortic segment from a donor animal into an allogeneic recipient. Rejection of the artery segment involves alloimmune reactions and results in arterial changes that resemble vascular rejection. The basic technical approach we describe can be used with different mouse strains and targeted interventions to answer specific questions related to vascular rejection and TA.

  14. Hybrid procedure on revascularization of arteriosclerosis obliterans on lower extremity%杂交手术在下肢动脉硬化性闭塞症血管重建中的价值

    Institute of Scientific and Technical Information of China (English)

    凌平; 肖乐; 龚昆梅; 王昆华; 欧阳一鸣

    2010-01-01

    目的 探讨杂交手术在下肢动脉硬化性闭塞症血管重建中的应用价值.方法 回顾性分析本院1998年1月至2009年8月收治血管重建的56例下肢动脉硬化性闭塞症多节段病变患者的临床资料,其中杂交手术32例,外科手术13例,血管腔内治疗11例.探讨3种血管重建方法在多节段病变血管重建的适应证、治疗效果、并发症及围手术期死亡率.结果 随访36例,随访时间2~101个月,平均随访时间53个月,随访率64.29%.杂交手术组远期通畅率明显高于外科手术和腔内治疗组(62.50% vs 30.76% vs 27.27%,ANOVA分析,F=54.17,P<0.05);临床疗效明显优于外科手术和腔内治疗组(有效率分别为56.25%、15.38%、13.64%,ANOVA分析,F=58.46,P<0.05;无效率分别为12.5%、61.54%、54.55%,ANOVA分析,F=54.23,P<0.05).并发症明显低于外科手术组,与腔内治疗组相当(12.5% vs 38.46% vs 18.19%,ANOVA分析,F=52.56,P<0.05).围手术期死亡率杂交手术和腔内治疗组均为0%,外科手术组为7.69%.结论 杂交手术对多节段病变患者更具优势,不仅能减少和降低麻醉及手术风险,而且能获得满意的临床疗效和远期通畅率.

  15. Quantitative detection of cerebral arteriosclerosis by means of the Doppler ultrasonic technique.

    Science.gov (United States)

    Miyazaki, M

    1986-01-01

    A correlation between the continuity of the cerebral blood flow pattern and the cerebral vascular resistance (namely, cerebral arteriosclerosis) was investigated by the Doppler ultrasonic technique. The following facts were observed. Examination of the brachial blood flow pattern in circulatory stress, i.e., hand-grasping, brachial-binding, cold- and warm-stimulating tests revealed that the more the peripheral vascular resistance was increased, the more was the discontinuity of brachial blood flow pattern increased. Investigation of the continuity of the cerebral blood flow pattern (internal carotid artery) in 18 young healthy persons and 46 elderly patients with cerebral vascular diseases revealed a continuous pattern in all of the young persons, while the discontinuous pattern was frequently observed in the elderly patients. These findings suggest that the cerebral vascular resistance is more increased in the elderly patients than in the young persons. The cerebral blood flow pattern was classified into the following three types according to the continuity of the cerebral blood flow pattern: continuous, intermediate and discontinuous type, and the relation to the Continuous Index (CI), which was devised as an objective parameter of the continuity, was examined. The following CI figures were obtained: 110-200% in the young persons; in the elderly patients: continuous type, 120-185%; intermediate type, 85-135%; discontinuous type, 50-85%. From the above findings it is postulated that the Doppler ultrasonic technique is useful for the quantitative detection of cerebral arteriosclerosis, i.e., anticipation of cerebral vascular accidents, and for the discrimination between arteriosclerotic dementia and Alzheimer's disease. PMID:3525327

  16. A case of radiation pulmonary injury simulating bronchiolitis obliterans organizing pneumonia following postoperative radiotherapy for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Katoh, Toshiyuki; Iwata, Masaru; Yoshida, Norio; Katagiri, Akira; Takeda, Naoya [Kariya General Hospital, Aichi (Japan)

    2001-09-01

    A 57-year-old female underwent conservative surgery for a left sided breast cancer, and received 48 Gy postoperative radiation therapy. One year later, a chest CT scan disclosed bilateral patchy ground glass opacities. She had no subjective symptom. These abnormal opacities disappeared spontaneously without any treatment. We considered this was a radiation lung injury simulating bronchiolitis obliterans organizing pneumonia. We emphasize that the symptomless and spontaneous resolution of this type of lung injury should be kept is mind. (author)

  17. On the treatment of cerebral arteriosclerosis from treating turbid blood%脑动脉硬化症从血浊论治探微

    Institute of Scientific and Technical Information of China (English)

    韩萍; 周永红; 唐明; 郭瑞友

    2016-01-01

    The thesis explores the mechanism of the treatment of cerebral arteriosclerosis from treating turbid blood by exploring the correlation between the turbid blood and cerebral arteriosclerosis, it elaborates that turbid blood is the pathological pivot of cerebral arteriosclerosis, therefore, purifying turbid blood is a vital measure in preventing and treating cerebral arteriosclerosis.%从血浊与脑动脉硬化症发病的相关性入手,深入探讨脑动脉硬化症从血浊论治的机理,论述血浊是脑动脉硬化症发病的病理枢纽,而清化血浊法为防治脑动脉硬化症的重要措施。

  18. Vacuum-compression therapy for ischemic disease of the extremities:experience with 40 patients

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To study the clinical effects of vacuum-compression therapy for ischemic disease of the extremities. Methods A total of 40 cases of peripheral arterial disorders,including 23 thromboangiitis obliterans (31 limbs) and 17 arteriosclerosis obliterans (23 limbs),were treated by a self-made vacuum-compression therapeutic apparatus. Results The effective rate in thromboangiitis obliterans and arteriosclerosis obliterans groups was 96.77% and 92.23%,respectively. The cuffs on the apparatus were improved ...

  19. Feasibility of microvascular head and neck reconstruction in the setting of calcified arteriosclerosis of the vascular pedicle.

    Science.gov (United States)

    Lee, Matthew K; Blackwell, Keith E; Kim, Brandon; Nabili, Vishad

    2013-03-01

    OBJECTIVE To report outcomes in free flap reconstructive surgery in the setting of calcified arteriosclerosis affecting the flap pedicle. DESIGN Retrospective review, including a detailed analysis of medical records, histopathologic findings, and a comprehensive review of the literature. METHODS A total of 1329 consecutive microvascular free tissue transfers were performed by 2 reconstructive surgeons at a university-affiliated tertiary care medical center from January 1, 1996, through December 31, 2011. Clinical notes, operative notes, and pathology reports were systematically reviewed to identify 44 patients (3%) with calcified arteriosclerosis involving the flap vascular pedicle. A comprehensive medical record review was performed for the included patients, detailing patient-related characteristics, flap survival, and incidence of perioperative complications. RESULTS A history of arteriosclerosis was identified preoperatively in 18 patients (41%). Eight patients (18%) were specifically recognized clinically and histologically to have a variant of arteriosclerosis known as Mönckeberg medial calcific sclerosis. In total, fibula osteocutaneous free flap was performed in 30 patients, radial forearm in 8 patients, rectus abdominus in 3 patients, latissimus dorsi in 2 patients, and parascapular in 1 patient. Perioperative complications occurred in 17 patients (39%), with the most common being pulmonary (14%) and cardiac (9%). Patient follow-up ranged from 3 to 137 months, with a mean postoperative follow-up of 21 months. The mean length of hospital stay was 12 days. There was a 0% incidence of total flap failure and a 7% incidence of partial flap necrosis. CONCLUSION Although technically challenging, successful microvascular free flap reconstruction can be achieved despite the presence of vascular calcifications affecting the flap vascular pedicle.

  20. The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots

    Directory of Open Access Journals (Sweden)

    Jovelić Aleksandra

    2009-01-01

    Full Text Available Background/Aim. Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pilots as representatives of healthy men. Methods. We studied 161 military pilots (age 38 ± 6 years free of cardiovascular disease and diabetes mellitus. Traditional and metabolic risk factors were determined. Plasma CRP was measured by immunonephelometry. The common carotid artery intima-media thickness was measured by ultrasonography in the posterior wall of both common carotid arteries. Results. A total of 66.5% subjects had common carotid artery intima-media thickness > 0.9 mm (p < 0.01. The mean CRP plasma concentration was significantly higher in the subjects with common carotid artery intima- media thickness > 0.9 mm than in those with common carotid artery intima-media thickness ≤ 0.9 mm. In a simple regression analysis age adjusted CRP was associated with common carotid artery intima-media thickness (β = 0.285, p < 0.01, and only high density lipoprotein cholesterol was not associated with common carotid artery intima-media thickness. The association between CRP and common carotid artery intima-media thickness remained highly significant after controlling for body mass index, blood pressure, total cholesterol, low density lipoprotein cholesterol, triglycerides, glycosylated hemoglobin and smoking (p < 0.01. Controlling for glucose, triglycerides to high density lipoprotein cholesterol ratio, and total cholesterol to high density lipoprotein cholesterol ratio resulted in some reduction in the strength of the association, but including waist

  1. Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans.

    Directory of Open Access Journals (Sweden)

    Cara N Halldin

    Full Text Available BACKGROUND: Bronchiolitis obliterans, an irreversible lung disease, was first associated with inhalation of butter flavorings (diacetyl in workers at a microwave popcorn company. Excess rates of lung-function abnormalities were related to cumulative diacetyl exposure. Because information on potential excess mortality would support development of permissible exposure limits for diacetyl, we investigated respiratory-associated mortality during 2000-2011 among current and former workers at this company who had exposure to flavorings and participated in cross-sectional surveys conducted between 2000-2003. METHODS: We ascertained workers' vital status through a Social Security Administration search. Causes of death were abstracted from death certificates. Because bronchiolitis obliterans is not coded in the International Classification of Disease 10(th revision (ICD-10, we identified respiratory mortality decedents with ICD-10 codes J40-J44 which encompass bronchitis (J40, simple and mucopurulent chronic bronchitis (J41, unspecified chronic bronchitis (J42, emphysema (J43, and other chronic obstructive pulmonary disease (COPD (J44. We calculated expected number of deaths and standardized mortality ratios (SMRs with 95% confidence intervals (CI to determine if workers exposed to diacetyl experienced greater respiratory mortality than expected. RESULTS: We identified 15 deaths among 511 workers. Based on U.S. population estimates, 17.39 deaths were expected among these workers (SMR = 0.86; CI:0.48-1.42. Causes of death were available for 14 decedents. Four deaths among production and flavor mixing workers were documented to have a multiple cause of 'other COPD' (J44, while 0.98 'other COPD'-associated deaths were expected (SMR = 4.10; CI:1.12-10.49. Three of the 4 'other COPD'-associated deaths occurred among former workers and workers employed before the company implemented interventions reducing diacetyl exposure in 2001. CONCLUSION: Workers

  2. Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Namekata Tsukasa

    2011-08-01

    Full Text Available Abstract Background A cardio-ankle vascular index (CAVI has been developed to represent the extent of arteriosclerosis throughout the aorta, femoral artery and tibial artery independent of blood pressure. To practically use CAVI as a diagnostic tool for determining the extent of arteriosclerosis, our study objectives were (1 to establish the baseline CAVI scores by age and gender among cardiovascular disease (CVD risk-free persons, (2 to compare CAVI scores between genders to test the hypothesis that the extent of arteriosclerosis in men is greater than in women, and (3 to compare CAVI scores between the CVD risk-free group and the CVD high-risk group in order to test the hypothesis that the extent of arteriosclerosis in the CVD high-risk group is greater than in the CVD risk-free group. Methods Study subjects were 32,627 urban residents 20-74 years of age who participated in CVD screening in Japan during 2004-2006. A new device (model VaSera VS-1000 was used to measure CAVI scores. At the time of screening, CVD high-risk persons were defined as those having any clinical abnormalities of CVD, and CVD risk-free persons were defined as those without any clinical abnormalities of CVD. Age-specific average CAVI scores were compared between genders and between the CVD risk-free group and the CVD high-risk group. Student's t-test using two independent samples was applied to a comparison of means between two groups. Results Average age-specific baseline scores of CAVI in the CVD risk-free group linearly increased in both genders as their age increased. Average age-specific baseline scores of CAVI in the CVD risk-free group were significantly greater among men than among women. Average age-specific baseline scores of CAVI in the CVD risk-free group were significantly smaller than those in the CVD high-risk group in both genders after 40 years of age. Conclusions The baseline CAVI scores from the CVD risk-free group are useful for future studies as

  3. Papel de los macrófagos en la patogénesis de la arteriosclerosis

    Directory of Open Access Journals (Sweden)

    Quintana Varón María del Pilar

    2007-12-01

    Full Text Available La arteriosclerosis es una enfermedad inflamatoria que es responsable del 50% de las muertes del mundo
    occidental por desencadenar complicaciones coronarias graves. Se produce por la acumulación excesiva de
    colesterol proveniente del torrente sanguíneo en la íntima arterial de arterias medias y grandes. Los monocitos circulantes se adhieren al endotelio activado y se diferencian en macrófagos al interior de la íntima
    arterial, donde se desempeñan como recolectores del exceso de colesterol. Desde ahí liberan citoquinas,
    proteasas, especies reactivas de oxigeno y factores de crecimiento que potencian la reacción inflamatoria,
    desempeñando un papel esencial en la patogénesis de la enfermedad. La población creciente de macrófagos
    eventualmente entra en apoptosis y necrosis, haciendo cada vez más grande e inestable la lesión arteriosclerótica, lo que en último momento es el detonante de las complicaciones clínicas graves que pueden terminar en la muerte del paciente.

  4. Clinical studies of cerebral arteriosclerosis in diabetic subjects. Analysis with brain MRI study

    International Nuclear Information System (INIS)

    In order to investigate the clinical characteristics of cerebral arteriosclerosis in diabetic subjects, brain MRI studies were conducted in diabetic patients and healthy subjects. The subjects were 93 diabetic patients without symptoms and signs of cerebral infarction (49 males and 44 females) with a mean age of 59 years and 73 healthy subjects (43 males and 30 females) with a mean age of 57 years. The MRI studies were performed on a General Electric 1.5-T signa system. The spin-echo technique (T2-weighted image) was used with a pulse repetition time (TR) of 2,500 msec and echo time (TE) of 80 msec. The quantitative evaluation of cerebral infarction was assessed using personal computer and image-scanner. By MRI, the incidence of cerebral infarction in diabetic patients was significantly higher than that in healthy subjects (30.1% vs. 13.7%, respectively, p<0.05). The mean age of the diabetic patients with cerebral infarctions was higher than that of those without cerebral infarctions. Hypertension and diabetic nephropathy were present more frequently in the subjects with cerebral infarctions. These data suggest that it is important to delay the onset and slow the progression of cerebral infarction in diabetic patients by strict blood glucose control and management of blood pressure. (author)

  5. Relevance of Plasma Obestatin and Early Arteriosclerosis in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Peng-ying Gu

    2013-01-01

    Full Text Available We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT in plasma of patients with type 2 diabetes mellitus (T2DM. We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years form January, 2007 to May, 2009. All patients were divided into normal glucose tolerance (NGT, impaired glucose tolerance (IGT, and T2DM according to the oral glucose tolerance test (OGTT. We found that higher levels of fasting insulin (Fins, fasting blood glucose, 2 h OGTT glucose, homeostasis model assessment of insulin resistance (HOMA-IR, low density lipoprotein cholesterol, glycated haemoglobin, and C-reactive protein (CRP, as well as lower obestatin level and higher intima-media thickness level (IMT, existed in T2DM group compared with NGT group and IGT group (P<0.01. Also, obestatin level was independently associated with HOMA-IR and CRP, while IMT level was independently associated with HOMA-IR, triglyceride, Fins, and obestatin (P<0.01, based on stepwise multiple regression analysis. Therefore, we deduced that the low level of plasma obestatin might be related to early arteriosclerosis in patients with T2DM via increasing IMT level, and elevated plasma obestatin levels might protect T2DM patients against carotid atherosclerosis to some extent.

  6. Two cases of bronchiolitis obliterans organizing pneumonia syndrome after the radiation of breast-conserving therapy

    International Nuclear Information System (INIS)

    Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a recently reported complication of the adjuvant radiotherapy of breast-conserving surgery. We report two cases of BOOP syndrome in 100 patients who underwent breast-conserving therapy. A 75 year-old woman had a cough 3 months after radiation therapy for cancer of the left breast. Chest radiography and computed tomography showed consolidation with air bronchograms in the upper left lung. Transbronchial lung biopsy showed lymphocyte infiltration and fibrosis in the alveoli. A 45-year old woman with bilateral breast cancer had a cough and palpitations for 3 month after radiation therapy for cancer of the right breast. Chest radiography and computed tomography showed consolidation in upper and middle fields of the left lung. Transbronchial lung biopsy showed granulation formation in the alveolar duct, which is a typical feature of BOOP. The symptoms and radiographic findings improved with oral administration of prednisolone. BOOP syndrome may occur as a complication of breast-conserving therapy. (author)

  7. Two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer

    International Nuclear Information System (INIS)

    We report two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer. One of the patients was a 58-year-old woman. She underwent a conserving surgery for bilateral breast cancers, and received radiation therapy to the remaining part of bilateral breasts. Two months after the termination of irradiation, cough, fever and general fatigue developed. We clinically diagnosed this case as BOOP after radiation therapy. After initiation of oral steroid therapy, the clinical symptoms and radiographic findings disappeared. Another patient was a 57 year-old woman. She underwent radical mastectomy for right breast cancer. A month after the operation, she suffered from local recurrence, so radiation therapy to the thoracic wall was performed. After irradiation, resection of the thoracic wall lesion was performed because of malignancy from local skin biopsy specimen. Two months after the termination of irradiation, cough, dyspnea and fever developed. We clinically diagnosed this case as radiation-induced BOOP by bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB) findings. After an initiation of steroid therapy, the clinical symptoms and radiographic findings disappeared. It is important to be aware of BOOP as a complication in the patient who was given radiation after surgery of breast cancer. (author)

  8. Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?

    International Nuclear Information System (INIS)

    In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases. The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated. Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP. For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance. (author)

  9. Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study

    Science.gov (United States)

    Politano, Gianfranco; Inghilleri, Simona; Morbini, Patrizia; Calabrese, Fiorella; Benso, Alfredo; Savino, Alessandro; Cova, Emanuela; Zampieri, Davide; Meloni, Federica

    2016-01-01

    The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the study of BOS. The analysis considered the full set of miRNAs annotated in miRBase (version 21), and applied a sequence of filtering approaches and statistical analyses to reduce this set and to score the candidate miRNAs according to their potential involvement in BOS development. Dysregulation of two of the selected candidate miRNAs–miR-34a and miR-21 –was clearly shown in in-situ hybridization (ISH) on five explanted human BOS lungs and on a rat model of acute and chronic lung rejection, thus definitely identifying miR-34a and miR-21 as pathogenic factors in BOS and confirming the effectiveness of the computational pipeline. PMID:27564214

  10. Oxygen-sensitive {sup 3}He-MRI in bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Gast, Klaus K. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, Mainz (Germany); Biedermann, Alexander [Klinikum der Johannes Gutenberg-Universitaet, 3. Medizinische Klinik, Pulmonologie, Mainz (Germany); Herweling, Annette [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Anaesthesiologie, Mainz (Germany); Schreiber, Wolfgang G. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, MR-Physik, Mainz (Germany); Schmiedeskamp, Joerg [Max-Planck-Institut fuer Polymerforschung, Mainz (Germany); Mayer, Eckhard [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Herz-, Thorax- und Gefaesschirurgie, Mainz (Germany); Heussel, Claus P. [Abteilung fuer Radiologie, Thoraxklinik Heidelberg, Heidelberg (Germany); Markstaller, Klaus; Eberle, Balthasar [Inselspital/Universitaetsspital, Klinik fuer Anaesthesiologie, Bern (Switzerland); Kauczor, Hans-Ulrich [Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany)

    2008-03-15

    Oxygen-sensitive {sup 3}He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO{sub 2}) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive {sup 3}He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acquired on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, {sup 3}He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO{sub 2} in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive {sup 3}He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive {sup 3}He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients. (orig.)

  11. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

    Directory of Open Access Journals (Sweden)

    Ching-Chang Cheng

    2011-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia (BOOP is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS, typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2 was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs, extracellular collagen matrix (ECM deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (<.05. Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.

  12. Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?

    Energy Technology Data Exchange (ETDEWEB)

    Mihara, Naoki; Johkoh, Takeshi [Osaka Univ., Suita (Japan). Medical School; Ichikado, Kazuya (and others)

    2000-10-01

    In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases. The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated. Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP. For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance. (author)

  13. Two cases of bronchiolitis obliterans organizing pneumonia syndrome after the radiation of breast-conserving therapy

    Energy Technology Data Exchange (ETDEWEB)

    Komuro, Youko; Nakagomi, Hiroshi; Akaike, Hidenori; Chiba, Shigehiro; Miyashita, Yoshihiro; Obu, S.; Yamaguchi, Motoshi; Oyama, Toshio [Yamanashi Prefectural Central Hospital, Kofu (Japan)

    2001-12-01

    Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a recently reported complication of the adjuvant radiotherapy of breast-conserving surgery. We report two cases of BOOP syndrome in 100 patients who underwent breast-conserving therapy. A 75 year-old woman had a cough 3 months after radiation therapy for cancer of the left breast. Chest radiography and computed tomography showed consolidation with air bronchograms in the upper left lung. Transbronchial lung biopsy showed lymphocyte infiltration and fibrosis in the alveoli. A 45-year old woman with bilateral breast cancer had a cough and palpitations for 3 month after radiation therapy for cancer of the right breast. Chest radiography and computed tomography showed consolidation in upper and middle fields of the left lung. Transbronchial lung biopsy showed granulation formation in the alveolar duct, which is a typical feature of BOOP. The symptoms and radiographic findings improved with oral administration of prednisolone. BOOP syndrome may occur as a complication of breast-conserving therapy. (author)

  14. Bronchiolitis obliterans following exposure to sulfur mustard: chest high resolution computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Ghanei, Mostafa E-mail: m.ghanei@bmsu.ac.ir; Mokhtari, Majid; Mohammad, Mehdi Mir; Aslani, Jafar

    2004-11-01

    Background: Pulmonary complications are known to occur in over half of the patients exposed to sulfur mustard (SM). Chemical weapons of mass destruction (WMD) including SM were used by Iraq during Iran-Iraq war between 1983 and 1989. We undertook this study to evaluate the chest high resolution computerized tomography (HRCT) as a diagnostic tool in patients with documented exposure to SM and chronic respiratory symptoms. Method: The medical records of 155 patients exposed to SM during Iran-Iraq war and suffered respiratory complications were reviewed. Chest HRCTs of these patients were examined. Ten healthy controls with no history of exposure to HD were matched for age, gender, and chest HRCT protocol applied. Results: Fifty chest HRCTs of these patients were randomly selected for this study. The most frequent findings were; air trapping 38 (76%), bronchiectasis 37 (74%), mosaic parenchymal attenuation (MPA) 36 (72%), irregular and dilated major airways 33 (66%) bronchial wall thickening (BWT) 45 (90%), and interlobular septal wall thickening (SWT) 13 (26%), respectively. Air trapping in one patient (10%) was the only positive finding in the control group. Conclusions: Chest HRCT findings of bronchiectasis, air trapping, MPA, SWT, and BWT were seen in our patients 15 years after exposure to HD. These findings suggest the diagnosis of bronchiolitis obliterans (BO). We did not encounter chest HRCT features consistent with pulmonary fibrosis.

  15. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Science.gov (United States)

    Bunawan, Hamidun; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd.

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr. PMID:26413127

  16. Sauropus androgynus (L. Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Directory of Open Access Journals (Sweden)

    Hamidun Bunawan

    2015-01-01

    Full Text Available Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr.

  17. Oxidative stress and nutritional intakes in lung patients with bronchiolitis obliterans syndrome.

    Science.gov (United States)

    Madill, J; Aghdassi, E; Arendt, B M; Gutierrez, C; Singer, L; Chow, C-W; Keshavjee, S; Allard, J P

    2009-11-01

    Survival after lung transplantation is limited by bronchiolitis obliterans syndrome (BOS). Oxidative stress (OxS) can be associated with BOS due to chronic inflammation. The type of fat and antioxidant intakes may also contribute to OxS. Our aim was to compare OxS and nutritional intakes in non-BOS versus various stages of BOS. Fifty-eight lung recipients with versus without BOS were prospectively classified as: non-BOS; BOS Op-1 (mild), and BOS 2-3 (severe). We measured nutritional intake and plasma vitamins A, C, and E. Among a subgroup of 37 patients, OxS was assessed by measuring lipid peroxidation (LPO micromol/L MDA) and oxidized glutathione (GSSG) in bronchoalveolar lavage BAL fluid (BALF). One-way analysis of variance was used to compare groups. Results are reported as mean values +/- standard errors of the mean. There was no significant difference in demographic features on time posttransplant among groups. Although there were comparable cell counts in BALF, severe BOS patients showed significantly higher BALF LPO concentrations when compared with milder stage of BOS or with non-BOS (P = .001, for both). Severe BOS recipients also displayed higher BALF GSSG concentrations compared to milder stage of BOS (P = .001) or non-BOS (P = .007). In conclusion, patients with severe BOS were more oxidatively stressed compared with mild and non-BOS recipients. PMID:19917398

  18. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology.

    Science.gov (United States)

    Bunawan, Hamidun; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the "multigreen" or "multivitamin" plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr. PMID:26413127

  19. Cell therapy in the treatment of bronchiolitis obliterans in a murine model

    Directory of Open Access Journals (Sweden)

    Julio de Oliveira Espinel

    2015-06-01

    Full Text Available OBJECTIVE: To evaluate the importance of stem cells derived from adipose tissue in reducing graft inflammation in a murine model of allogeneic heterotopic tracheal transplant.METHODS: We performed a heterotopic tracheal allografting in dorsal subcutaneous pouch and systemically injected 5x105 mesenchymal stem cells derived from adipose tissue. The animals were divided into two groups according to the time of sacrifice: T7 and T21. We also carried out histological analysis and digital morphometry.RESULTS: The T7 animals treated with cell therapy had median obstructed graft area of 0 versus 0.54 of controls (p = 0.635. The treated T21 subjects had median obstructed graft area of 0.25 versus 0 in controls (p = 0.041.CONCLUSION: The systemically injected cell therapy in experimental murine model of bronchiolitis obliterans did not reduce the severity of the allograft inflammation in a statistically significant way in seven days; Conversely, in 21 days, it increased the allograft inflammatory process.

  20. Bronchiolitis obliterans organizing pneumonia in a case of multiple myeloma: an unusual association and discussion

    Directory of Open Access Journals (Sweden)

    Ramita Sarkar

    2014-12-01

    Full Text Available A male patient with respiratory distress for the last 2 months followed by gradual onset drowsiness and disorientation for the last 4-5 days is presented. On investigation he was found to be suffering from multiple myeloma (MM with features of hypercalcemia, lytic bone lesions, renal compromise and anemia complicated by meningoencephalitis. He was also found to be inflicted with bronchiolitis obliterans organizing pneumonia (BOOP as diagnosed by chest computerized tomography and transbronchial biopsy. Whether this association is sporadic or has some pathophysiological basis still remains to be discovered, though recurrent pneumonias due to immunosuppression in MM may be a possible etiopathological factor. The patient was stabilized and discharged on request but he presented again after 2 months with features of hypercalcemia in spite of getting a dose of zolendronate during the previous admission. This time he was given prednisolone and melphalan and was discharged in a stable condition after being counseled for follow-up visits. [J Exp Integr Med 2014; 4(4.000: 227-231

  1. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

    Directory of Open Access Journals (Sweden)

    Ronaldo Soares Martins

    2012-10-01

    Full Text Available The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP. Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV treatment.

  2. Pulmonary radiation injury manifested by signs of bronchiolitis obliterans with organizing pneumonia after postoperative breast cancer radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ogata, Kenichi; Shibata, Kazumi; Nishio, Tetsuo [Kitakyusyu Municipal Medical Center, Fukuoka (Japan); Kawarada, Yuji; Hara, Nobuyuki

    1999-12-01

    A 67-year-old woman underwent surgery for cancer of both breast (right: mastectomy, left: conserving surgery), and received 60 Gy radiation to the left postoperative breast. Three months later, cough and fever developed. A chest radiograph demonstrated infiltrative shadows in the left lung field. Transbronchial lung biopsy specimens disclosed organizing exudates in the alveolar spaces and bronchioles. After treatment with prednisolone, the clinical symptoms and radiographic infiltrates disappeared. This was a case of pulmonary radiation injury pathologically manifested by signs of bronchiolitis obliterans with organizing pneumonia. (author)

  3. 闭塞性细支气管机化性肺炎%Bronchiolitis obliterans organizing pneumonia

    Institute of Scientific and Technical Information of China (English)

    卢宏柱; 赵亮

    2011-01-01

    @@ 闭塞性细支气管机化性肺炎(bronchiolitis obliterans organizing pneumonia,BOOP)是一个临床病理术语,其特征是以细支气管腔、肺泡管以及一些肺泡有肉芽组织形成,伴有间质和气腔内不同程度的单核细胞和泡沫巨噬细胞的浸润[1-2].

  4. Human cytomegalovirus infection leads to elevated levels of transplant arteriosclerosis in a humanized mouse aortic xenograft model.

    Science.gov (United States)

    Abele-Ohl, S; Leis, M; Wollin, M; Mahmoudian, S; Hoffmann, J; Müller, R; Heim, C; Spriewald, B M; Weyand, M; Stamminger, T; Ensminger, S M

    2012-07-01

    Recent findings emphasized an important role of human cytomegalovirus (HCMV) infection in the development of transplant arteriosclerosis. Therefore, the aim of this study was to develop a human peripheral blood lymphocyte (hu-PBL)/Rag-2(-/-) γc(-/-) mouse-xenograft-model to investigate both immunological as well as viral effector mechanisms in the progression of transplant arteriosclerosis. For this, sidebranches from the internal mammary artery were recovered during coronary artery bypass graft surgery, tissue-typed and infected with HCMV. Then, size-matched sidebranches were implanted into the infrarenal aorta of Rag-2(-/-) γc(-/-) mice. The animals were reconstituted with human peripheral blood mononuclear cells (PBMCs) 7 days after transplantation. HCMV-infection was confirmed by Taqman-PCR and immunofluorescence analyses. Arterial grafts were analyzed by histology on day 40 after transplantation. PBMC-reconstituted Rag-2(-/-) γc(-/-) animals showed splenic chimerism levels ranging from 1-16% human cells. After reconstitution, Rag-2(-/-) γc(-/-) mice developed human leukocyte infiltrates in their grafts and vascular lesions that were significantly elevated after infection. Cellular infiltration revealed significantly increased ICAM-1 and PDGF-R-β expression after HCMV-infection of the graft. Arterial grafts from unreconstituted Rag-2(-/-) γc(-/-) recipients showed no vascular lesions. These data demonstrate a causative relationship between HCMV-infection as an isolated risk factor and the development of transplant-arteriosclerosis in a humanized mouse arterial-transplant-model possibly by elevated ICAM-1 and PDGF-R-β expression.

  5. Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome

    Science.gov (United States)

    Zhang, Su-Bei; Sun, Xin; Wu, Qi; Wu, Jun-Ping; Chen, Huai-Yong

    2016-01-01

    Background: Bronchiolitis obliterans syndrome (BOS) often develops in transplant patients and results in injury to the respiratory and terminal airway epithelium. Owing to its rising incidence, the pathogenesis of BOS is currently an area of intensive research. Studies have shown that injury to the respiratory epithelium results in dysregulation of epithelial repair. Airway epithelial regeneration is supported by stromal cells, including fibroblasts. This study aimed to investigate whether the supportive role of lung fibroblasts is altered in BOS. Methods: Suspensions of lung cells were prepared by enzyme digestion. Lung progenitor cells (LPCs) were separated by fluorescence-activated cell sorting. Lung fibroblasts from patients with BOS or healthy controls were mixed with sorted mouse LPCs to compare the colony-forming efficiency of LPCs by counting the number of colonies with a diameter of ≥50 μm in each culture. Statistical analyses were performed using the SPSS 17.0 software (SPSS Inc., USA). The paired Student's t-test was used to test for statistical significance. Results: LPCs were isolated with the surface phenotype of CD31- CD34- CD45- EpCAM+ Sca-1+. The colony-forming efficiency of LPCs was significantly reduced when co-cultured with fibroblasts isolated from patients with BOS. The addition of SB431542 increased the colony-forming efficiency of LPCs to 1.8%; however, it was still significantly less than that in co-culture with healthy control fibroblasts (P < 0.05). Conclusion: The epithelial-supportive capacity of fibroblasts is impaired in the development of BOS and suggest that inefficient repair of airway epithelium could contribute to persistent airway inflammation in BOS. PMID:27569228

  6. Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    MO Xiao-dong; XU Lan-ping; LIU Dai-hong; ZHANG Xiao-hui; CHEN Huan; CHEN Yu-hong; HAN Wei

    2013-01-01

    Background The occurrence of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (alIo-HSCT) is rare but severe.We examine the role of pre-HSCT chemotherapeutic exposure,pre-HSCT comorbidities,and transplant-related complications in the development of BOS after allo-HSCT.Methods A nested case-control study was designed.Cases with BOS and controls matched for the year of alIo-HSCT and length of the follow-up were identified from a cohort of 1646 patients who underwent alIo-HSCT for treatment of hematologic malignancies between 2006 and 2011.Antithymocyte globulin was used in the partial matched related and unrelated matched donor HSCT,or patients with severe aplastic anemia.Results Thirty-six patients suffered from BOS; the mean age at the time of presentation was (32.7±12.4) years,and the mean time to presentation was (474±350) days post-HSCT.A pre-HSCT cyclophosphamide dose of >3.2 g/m2 (OR=8.74,P=0.025),chronic graft-versus-host disease (moderate to severe) (OR=12.02,P=0.000),and conditioning regimens without antithymocyte globulin (OR=2.79,P=0.031) were independently associated with BOS.Conclusions We found that higher pre-HSCT cyclophosphamide exposure,a conditioning regimen without antithymocyte globulin,and moderate to severe chronic graft-versus-host disease are significantly and independently associated with BOS.Based on these results,we can identify patients who are at a higher risk of developing BOS after alIo-HSCT,select a more appropriate therapeutic strategy,and improve the outcome of HSCT recipients.

  7. Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans.

    Science.gov (United States)

    He, T; Qu, B H; Wang, D L; Hu, M

    2015-06-18

    We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining). The animals were killed at various times following the operation and serum and muscle tissues were sampled. For the sham group: the endometrium was relatively intact; medial membrane and epineurium lesions were absent; and blood vessels and surrounding tissues had no inflammatory cell infiltration. For the model group: all subgroups displayed inflammation; large numbers of inflammatory cells were gathered; muscle tissue lost its normal texture and structure; and the internal elastic membrane was integrated. Compared with the preoperative status, HIF-1α expression increased significantly in all subgroups (P < 0.05); there was no change in the sham group. HIF-1α expression in each subgroup was different (F = 14.267, P < 0.05). Femoral artery injection of lauric acid can be used as a rat TO model owing to its simple application and success rate. HIF-1α expression increased in the early stage of TO and gradually decreased with the extension of ischemia time; it may play a leading role in TO development and can be used for diagnosis and cure evaluation.

  8. The number of FoxP3+ cells in transbronchial lung allograft biopsies does not predict bronchiolitis obliterans syndrome within the first five years after transplantation

    DEFF Research Database (Denmark)

    Krustrup, Dorrit; Iversen, Martin; Martinussen, Torben;

    2015-01-01

    Background: An important limitation to the success of lung transplantation is the development of bronchiolitis obliterans syndrome (BOS). It has been hypothesized that regulatory T lymphocytes (Tregs) are related to the risk of BOS. We aim to evaluate whether the number of forkhead box P3 (FoxP3...

  9. Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects.

    Science.gov (United States)

    Satoh, Hiroki; Fujii, Satoshi; Tsutsui, Hiroyuki

    2015-01-01

    Depression often coexists with hypertension and various cardiovascular diseases. However, the relationship between depression and the development of arteriosclerosis has not been fully established. We assessed depression and brachial-ankle pulse wave velocity (baPWV) in 828 middle-aged Japanese male subjects at baseline and during 3 years of follow-up. Depression was assessed using Center for Epidemiological Studies-Depression questionnaires, and the study subjects were divided into the following three groups: persistent depression, transient depression and no depression. The number (%) of subjects with persistent, transient and no depression were 104 (12.6), 76 (9.2) and 648 (78.2), respectively. Blood pressure and baPWV did not differ among the three groups at baseline. The changes in the baPWV values (⊿baPWV) correlated significantly and positively with age, body mass index, baseline systolic blood pressure and persistent depression (r = 0.32, P arteriosclerosis in middle-aged Japanese male subjects.

  10. Bronchiolitis obliterans organising pneumonia. A report of 11 cases and a review of the literature.

    Science.gov (United States)

    Lamont, J; Verbeken, E; Verschakelen, J; Demedts, M

    1998-10-01

    The clinical syndrome "Bronchiolitis Obliterans Organising Pneumonia" (BOOP) has to be considered in patients with a flu-like illness since some weeks, fine crackles, and on chest X-ray bilateral patchy infiltrates. There is no response to antibiotics. BOOP is essentially idiopathic, but associations to other conditions exist. Lung function is often restrictive; biochemistry is not pathognomonic. BAL shows a mixed cellular pattern. The gold standard for pathologic diagnosis is open or thoracoscopic lung biopsy. However, a BOOP pattern or reaction is often seen on histologic specimens without the clinical-radiologic features of the BOOP-entity. Therapy consists of corticosteroids, which have to be prescribed for a long time at a rather high dose. Recurrence is frequent, but prognosis is good. Evolution to respiratory insufficiency and death is rare and may occur in rapidly progressive BOOP. This study reports on 11 cases (6 males/5 females) of clinical-pathological BOOP-syndrome (mean age 58 yrs, range 17-73 yrs), with an unexpectedly high mortality rate of 36% (4 cases). The disease was idiopathic in 7, and was associated with intake of amiodarone (in 1), with past Mycoplasma pneumonia (in 1) and with connective tissue disease (in 2). There was a history of a flu-like syndrome, cough and dyspnea of a mean duration of 4 months (range 1 week to 8 months). Lung function was mostly restrictive or/and obstructive with a diffusing capacity ranging between 47 and 95% predicted; there was hypoxia in about half of the patients. Chest X-ray and computed tomography (CT) scan showed a patchy consolidation with linear opacities (unilateral in 4 patients, bilateral in 5) and/or a ground glass pattern (in 4 patients), and a focal pseudo-tumoral lesion (in 1). Bronchoalveolar lavage showed a variable pattern of mixed, or eosinophilic or neutrophilic alveolitis. Histologic diagnosis was based on open lung biopsy (in 3), on thoracoscopic biopsy (in 2), on transbronchial biopsy (in 2

  11. Bronchiolitis Obliterans Organizing Pneumonia as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case Report and Literature Review

    Science.gov (United States)

    Wang, Hung-Ping; Chen, Chun-Ming; Chen, Yih-Yuan; Chen, Wei

    2016-01-01

    The etiology of bronchiolitis obliterans organizing pneumonia (BOOP) remains controversial. While it has been reportedly associated with several connective tissue disorders, there are only rare reports of BOOP associated with systemic lupus erythematosus (SLE). Herein, we report a 56-year-old female patient who presented with dyspnea on exertion, cough, fever, and joint pain of her left wrist and fingers as initial symptoms. Laboratory tests revealed positivity for anti-nuclear antibody, anti-Ro, and anti-double strand DNA antibody. In this case, the patient with SLE had respiratory illness as the initial symptom due to BOOP in the absence of clear etiology. The diagnosis of BOOP was confirmed by thoracic surgery biopsy. Her respiratory symptoms and radiologic findings significantly improved following prednisolone treatment. PMID:27200095

  12. Migratory pneumonitis similar to bronchiolitis obliterans organizing pneumonia after conservative treatment of breast cancer. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Matsuura, Kanji; Hirokawa, Yutaka; Matsuura, Akiko; Akagi, Yukio; Ito, Katsuhide [Hiroshima Univ. (Japan). School of Medicine

    1999-07-01

    We report the case of a 63-year-old woman who developed cough and fever with migratory lung infiltrates three months after completion of right breast irradiation following conservative surgery. Lung infiltrates were initially localized in the irradiated area, but later spread to unirradiated areas in both lungs. No cause of migratory pneumonitis other than irradiation was found, and we clinically diagnosed this case as radiation-induced migratory pneumonitis similar to Bronchiolitis Obliterans Organizing Pneumonia(BOOP), without lung biopsy. Steroid therapy resulted incomplete resolution of lung infiltrates. The reported case clearly differed from typical radiation pneumonitis. We suggest that lung irradiation might trigger the development of migratory pneumonitis with a clinical pattern similar to that of BOOP. (author)

  13. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease: Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy

    Directory of Open Access Journals (Sweden)

    Ignacio López de Maturana

    2013-01-01

    Full Text Available Thromboangiitis obliterans (TAO or Buerger's disease is associated with both distal ulcers in the extremities and the possibility of amputation. The only treatment that has been shown to be effective in TAO is complete abstention from smoking. In spite of this, the disease progresses in up to 30 percent of cases and finally results in limb amputation. Only a few pharmacological and surgical options are available to date to improve healing ulcers in TAO. The efficacy of prostaglandin analogues is controversial. This paper summarizes the current evidence for medical treatment with bosentan in chronic ulcers in TAO patients. These available data up to date allow us to conclude that the beneficial effects of bosentan on improving endothelial function, inflammatory processes, and selective vasodilatation of damaged vessels result in a clinical enhancement regarding healing and preventive digital ulcers in such patients. In any case, these promising findings have to be confirmed with larger randomised trials.

  14. The Origin of Neointimal Smooth Muscle Cells in Transplant Arteriosclerosis from Recipient Bone-marrow Cells in Rat Aortic Allograft

    Institute of Scientific and Technical Information of China (English)

    SONG Zifang; LI Wei; ZHENG Qichang; SHANG Dan; SHU Xiaogang; GUAN Siming

    2007-01-01

    In order to investigate the origin of neointimal smooth muscle cells in transplant arteriosclerosis in rat aortic allograft, sex-mismatched bone marrow transplantation was performed from male Wistar rats to female Wistar rats. Four weeks after transplantation, the aortic transplant model was established by means of micro-surgery in rats. The recipients were divided into 4 groups: female Wistar-female Wistar aortic isografts, female SD-female Wistar aortic allografts, male SD-male Wistar aortic allografts, female SD-chimera Wistar aortic allografts. Eight weeks after transplantation, aortic grafts were removed at autopsy and processed for histological evaluation and immunohistochemistry. The results indicated that excessive accumulation of α-SMA-positive smooth muscle cells resulted in significant neointima formation and vascular lumen stricture in rat aortic allografts.Neointima assay revealed that the neointimal area and NIA/MA ratio of transplanted artery were significantly increased in all of aortic allograft groups as compared with those in aortic isograft group (P<0.01). Neointimal smooth muscle cells were harvested from cryostat sections of aortic allograft by microdissection method. The Sry gene-specific PCR was performed, and the result showed that a distinct DNA band of 225 bp emerged in the male-male aortic allograft group and chimera aortic allograft group respectively, but not in the female-female aortic allograft group. It was suggested that recipient bone-marrow cells, as the origin of neointimal smooth muscle cells, contributed to the pathological neointimal hyperplasia of aortic allograft and transplant arteriosclerosis.

  15. Improving survival outcomes in lung transplant recipients through early detection of bronchiolitis obliterans: Daily home spirometry versus standard pulmonary function testing

    OpenAIRE

    Robson, Kevin S; West, Andrew J.

    2014-01-01

    BACKGROUND: Long-term lung transplant success is limited by bronchiolitis obliterans syndrome (BOS), a form of chronic allograft rejection that manifests in the majority of patients by five years post-transplant. Frequent monitoring of pulmonary function measurements through the use of daily home spirometry may have the capability to detect the onset of BOS sooner than standard pulmonary function testing. Early detection of BOS would confer a treatment advantage that may improve survival outc...

  16. Bronquiolitis obliterante con neumonía organizada y enfermedad de Crohn Bronchiolitis obliterans organizing pneumonia and Crohn’s disease

    Directory of Open Access Journals (Sweden)

    P. Gil-Simón

    2008-03-01

    Full Text Available Las manifestaciones extraintestinales respiratorias en la enfermedad inflamatoria intestinal (EII son excepcionales. Presentamos un caso de bronquiolitis obliterante con neumonía organizada (BONO en paciente con enfermedad de Crohn, en remisión clínica sin tratamientos farmacológicos.Extraintestinal respiratory manifestations in inflammatory bowel disease (IBD are rare. We present a case of bronchiolitis obliterans organizing pneumonia (BOOP in a patient with Crohn's disease, with clinical remission with no drug therapy.

  17. 儿童感染后闭塞性细支气管炎研究进展%Post-infectious bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    吴小英

    2012-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种由严重小气道炎症损伤引起的少见的慢性气道阻塞性肺疾病.BO常见病因有感染、心肺或骨髓移植、吸入有毒物质、胃食管反流、结缔组织病及药物性等.儿童以感染后BO(post-infectious bronchiolitis obliterans,PIBO)最常见.文章综述PIBO研究进展.%Bronchiolitis obliterans (BO) is a rare form of chronic obstructive lung disease that follows a severe inflammatory insult to the small airways. The common etiologies of BO include infection, transplantations of the lung, the heart or the bone-marrow, toxic inhalation, gastroesophageal reflux, connective tissue disorders, drugs and so on. In children, post-infectious BO (PIBO) is the most common form. This article reviews the recent progress of PIBO in children.

  18. Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis.

    Science.gov (United States)

    Nicolle, A P; Carlos Sampedrano, C; Fontaine, J J; Tessier-Vetzel, D; Goumi, V; Pelligand, L; Pouchelon, J-L; Chetboul, V

    2005-03-01

    A 12-year-old sexually intact male Vendee Griffon Basset was presented for acute pulmonary oedema. Severe systemic systolic arterial hypertension (SAH) was diagnosed (290 mmHg). Despite blood and abdominal ultrasound tests, the underlying cause of the systemic hypertension could not be determined, and primary SAH was therefore suspected. Conventional echocardiography showed eccentric left ventricular hypertrophy with normal fractional shortening. Despite this apparent normal systolic function, 2D colour tissue Doppler imaging (TDI) identified a marked longitudinal systolic left ventricular myocardial alteration, whereas radial function was still preserved. Three months later, the dog underwent euthanasia because of an acute episode of distal aortic thromboembolism. Necropsy revealed severe aortic and iliac arteriosclerosis. SAH related to arteriosclerosis is a common finding in humans, but has not been previously described in dogs. Moreover, its consequence on longitudinal myocardial function using TDI has never been documented before in this species.

  19. Endothelial Cell Apoptosis Induces TGF-β Signaling-Dependent Host Endothelial-Mesenchymal Transition to Promote Transplant Arteriosclerosis.

    Science.gov (United States)

    Li, J; Xiong, J; Yang, B; Zhou, Q; Wu, Y; Luo, H; Zhou, H; Liu, N; Li, Y; Song, Z; Zheng, Q

    2015-12-01

    Endothelial cells (ECs) apoptosis is an initial event in transplant arteriosclerosis (TA), resulting in allograft function loss. To elucidate the precise mechanisms of ECs apoptosis leading to neointimal smooth muscle cells (SMCs) accumulation during TA. We induced apoptosis in cultured ECs by overexpressing p53 through lentivirus-mediated transfection. ECs apoptosis induced the production of transforming growth factor (TGF)-β1 in both apoptotic and neighboring viable cells, leading to increased TGF-β1 in the culture media. Conditioned media from Ltv-p53-transfected ECs further promoted transition of cultured ECs to SM-like cells by activating TGF-β/Smad3, PI3K/Akt/mTOR, and MAPK/ERK signaling in a TGF-β-dependent manner. In transgenic rat aorta transplantation models, inhibition of ECs apoptosis in Bcl-xL(+/+) knock-in rat aortic allografts significantly reduced TGF-β1 production both in allograft endothelia and in blood plasma, which in turn decreased accumulation of SM22α+ cells from transgenic recipient ECs originally marked with EGFP knock-in in neointima and alleviated TA. Systemic treatment with SIS3, AP23573, or PD98059 also prevented recipient ECs-originated SM-like cells accumulation and intima hyperplasia in aortic allografts. These data suggest that allograft EC apoptosis induced recipient endothelial-mesenchymal (smooth muscle) transition via TGF-β signaling, resulting in recipient EC-derived SMC accumulation as a major mechanism of vascular remodeling during TA.

  20. Managing bronchiolitis obliterans syndrome (BOS) and chronic lung allograft dysfunction (CLAD) in children: what does the future hold?

    Science.gov (United States)

    Snell, Gregory I; Paraskeva, Miranda; Westall, Glen P

    2013-08-01

    The success of pediatric lung transplantation continues to be limited by long-term graft dysfunction. Historically this has been characterized as an obstructive spirometric defect in the form of the bronchiolitis obliterans syndrome (BOS). It is recognized, however, that this does not reflect many of the other acknowledged etiologies of chronic lung dysfunction-noting it is the sum of the parts that contribute to respiratory morbidity and mortality after transplant. The term chronic lung allograft dysfunction (CLAD) has been coined to reflect these other entities and, in particular, a group of relatively recently described lung disorders called the restrictive allograft syndrome (RAS). RAS is characterized by a restrictive spirometric defect. Although these entities have not yet been studied in a pediatric setting their association with poor compliance, antibody-mediated rejection (AMR), and post-infectious lung damage (particularly viral) warrants attention by pediatric lung transplant teams. Current therapy for the BOS subset of CLAD is otherwise limited to changing immunosuppressants and avoiding excessive infectious risk by avoiding over-immunosuppression. Long-term macrolide therapy in lung transplantation is not of proven efficacy. Reviewing previous BOS studies to explore restrictive spirometric cases and joint projects via groups like the International Pediatric Lung Transplant Collaborative will be the way forward to solve this pressing problem.

  1. Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost.

    Science.gov (United States)

    Melillo, Elio; Grigoratos, Chrysanthos; Sanctis, Francesco De; Spontoni, Paolo; Nuti, Marco; Dell'Omodarme, Matteo; Ferrari, Mauro; Balbarini, Alberto

    2015-07-01

    We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPo 2) and carbon dioxide (TcPco 2) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44°C (P < .005). Forefoot maximal hyperemic test at 44°C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

  2. Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0p in Chronic Graft-versus-Host Disease of the Lung

    Science.gov (United States)

    Abedin, Sameem; Yanik, Gregory A.; Braun, Thomas; Pawarode, Attaphol; Magenau, John; Goldstein, Steven C.; Levine, John E.; Kitko, Carrie L.; Couriel, Daniel R.

    2016-01-01

    Bronchiolitis obliterans syndrome (BOS) is a significant post-transplant complication with low survival. BOS stage 0p (BOS 0p) is a parameter detected on pulmonary function tests (PFTs) after lung transplantation to identify patients at risk to develop BOS. We performed a retrospective study on 442 patients who underwent allogeneic stem cell transplant from 2007 to 2011 to evaluate whether development of BOS 0p is a risk factor in this population for BOS. Patients who met criteria for BOS 0p were significantly more likely to develop BOS (hazard ratio [HR], 3.22; P HR, 2.48; P =.001) and chronic graft-versus-host disease (GVHD) outside the lung post-transplant (HR, 23; P < .001). Finally, BOS 0p criteria were adequately sensitive in predicting BOS (85%), with a high negative predictive value (98%). Our findings suggest a routine PFT screening strategy with the intent of detecting BOS 0p, especially among patients with prior lung disease and who developed chronic GVHD, could suitably identify an at-risk population for the development of BOS. PMID:25687798

  3. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

    International Nuclear Information System (INIS)

    To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. (orig.)

  4. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Gi [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Ajou University Medical Center, Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of); Shin, Hyun Joo; Kim, Myung-Joon; Lee, Mi-Jung [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Kim, Yoon Hee; Sohn, Myung Hyun; Kim, Kyung Won [Yonsei University College of Medicine, Department of Pediatrics and Institute of Allergy, Severance Children' s Hospital, Seoul (Korea, Republic of); Lyu, Chuhl Joo [Yonsei University College of Medicine, Department of Pediatric Hematology and Oncology, Severance Children' s Hospital, Seoul (Korea, Republic of)

    2015-10-15

    To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. (orig.)

  5. Proteomic Characterization Reveals That MMP-3 Correlates With Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Cell and Lung Transplantation.

    Science.gov (United States)

    Liu, X; Yue, Z; Yu, J; Daguindau, E; Kushekhar, K; Zhang, Q; Ogata, Y; Gafken, P R; Inamoto, Y; Gracon, A; Wilkes, D S; Hansen, J A; Lee, S J; Chen, J Y; Paczesny, S

    2016-08-01

    Improved diagnostic methods are needed for bronchiolitis obliterans syndrome (BOS), a serious complication after allogeneic hematopoietic cell transplantation (HCT) and lung transplantation. For protein candidate discovery, we compared plasma pools from HCT transplantation recipients with BOS at onset (n = 12), pulmonary infection (n = 16), chronic graft-versus-host disease without pulmonary involvement (n = 15) and no chronic complications after HCT (n = 15). Pools were labeled with different tags (isobaric tags for relative and absolute quantification), and two software tools identified differentially expressed proteins (≥1.5-fold change). Candidate proteins were further selected using a six-step computational biology approach. The diagnostic value of the lead candidate, matrix metalloproteinase 3 (MMP3), was evaluated by enzyme-linked immunosorbent assay in plasma of a verification cohort (n = 112) with and without BOS following HCT (n = 76) or lung transplantation (n = 36). MMP3 plasma concentrations differed significantly between patients with and without BOS (area under the receiver operating characteristic curve 0.77). Consequently, MMP3 represents a potential noninvasive blood test for diagnosis of BOS. PMID:26887344

  6. Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells.

    Directory of Open Access Journals (Sweden)

    Aric L Gregson

    Full Text Available Bronchiolitis obliterans syndrome (BOS is the major obstacle to long-term survival after lung transplantation, yet markers for early detection and intervention are currently lacking. Given the role of regulatory T cells (Treg in modulation of immunity, we hypothesized that frequencies of Treg in bronchoalveolar lavage fluid (BALF after lung transplantation would predict subsequent development of BOS. Seventy BALF specimens obtained from 47 lung transplant recipients were analyzed for Treg lymphocyte subsets by flow cytometry, in parallel with ELISA measurements of chemokines. Allograft biopsy tissue was stained for chemokines of interest. Treg were essentially all CD45RA(-, and total Treg frequency did not correlate to BOS outcome. The majority of Treg were CCR4(+ and CD103(- and neither of these subsets correlated to risk for BOS. In contrast, higher percentages of CCR7(+ Treg correlated to reduced risk of BOS. Additionally, the CCR7 ligand CCL21 correlated with CCR7(+ Treg frequency and inversely with BOS. Higher frequencies of CCR7(+ CD3(+CD4(+CD25(hiFoxp3(+CD45RA(- lymphocytes in lung allografts is associated with protection against subsequent development of BOS, suggesting that this subset of putative Treg may down-modulate alloimmunity. CCL21 may be pivotal for the recruitment of this distinct subset to the lung allograft and thereby decrease the risk for chronic rejection.

  7. Bronchial wall measurements in patients after lung transplantation: evaluation of the diagnostic value for the diagnosis of bronchiolitis obliterans syndrome.

    Directory of Open Access Journals (Sweden)

    Sabine Dettmer

    Full Text Available OBJECTIVES: To prospectively evaluate quantitative airway wall measurements of thin-section CT for the diagnosis of Bronchiolitis Obliterans Syndrome (BOS following lung transplantation. MATERIALS AND METHODS: In 141 CT examinations, bronchial wall thickness (WT, the wall area percentage (WA% calculated as the ratio of the bronchial wall area and the total area (sum of bronchial wall area and bronchial lumen area and the difference of the WT on inspiration and expiration (WTdiff were automatically measured in different bronchial generations. The measurements were correlated with the lung function parameters. WT and WA% in CT examinations of patients with (n = 25 and without (n = 116 BOS, were compared using the unpaired t-test and univariate analysis of variance, while also considering the differing lung volumes. RESULTS: Measurements could be performed in 2,978 bronchial generations. WT, WA%, and WTdiff did not correlate with the lung function parameters (r<0.5. The WA% on inspiration was significantly greater in patients with BOS than in patients without BOS, even when considering the dependency of the lung volume on the measurements. WT on inspiration and expiration and WA% on expiration did not show significant differences between the groups. CONCLUSION: WA% on inspiration was significantly greater in patients with than in those without BOS. However, WA% measurements were significantly dependent on lung volume and showed a high variability, thus not allowing the sole use of bronchial wall measurements to differentiate patients with from those without BOS.

  8. ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

    Directory of Open Access Journals (Sweden)

    V. Z. Krivitskaya

    2015-01-01

    Full Text Available Exacerbation of bronchial asthma (BA and common deterioration of health during chronic bronchiolitis obliterans (ChBO are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50% in patients with BA. Influenza A(H1N1pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1pdm09 (63% of seroconversions. There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1 pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity. 

  9. Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer.

    Science.gov (United States)

    Al-Hameed, Fahad M

    2015-06-01

    A 62-year-old woman underwent a right mastectomy with axillary node dissection for a poorly differentiated ductal carcinoma. One month later, she underwent a left nephrectomy for a renal cell carcinoma. Two weeks after, she received her first cycle of cyclophosphamide, methotrexate, and 5FU (CMF) as a part of her breast cancer treatment. We describe an unusual case of non-occlusive saddle pulmonary embolus with extensive bilateral deep vein thrombosis and severe bronchiolitis obliterans with organizing pneumonia developing simultaneously after the first CMF chemotherapy for breast cancer. PMID:25987120

  10. Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome in breast cancer patients is associated with age

    International Nuclear Information System (INIS)

    Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a rarely observed phenomenon characterized by infiltration of the lungs outside of the radiation field, differentiating it from radiation pneumonitis (RP).The risk factors for radiation-induced BOOP (RT-BOOP) remain unclear and controversial. We retrospectively analyzed the incidence and risk factors for RT-BOOP associated with radiation therapy (RT) after breast conserving surgery (BCS) and post-mastectomy radiation therapy (PMRT). We analyzed 1,176 breast cancer patients treated with RT after BCS or PMRT between March 2005 and September2008 at the cancer institute hospital of the Japanese foundation for cancer research. Chest radiographs were routinely obtained every three to six months for at least 12 months after surgery, as well as when the patients experienced respiratory symptoms or fever. RT-BOOP syndrome was diagnosed in 16patients (1.4%), including12BCS patients (1.3%) and four PMRT patients (1.8%). An older age (≥52 years old) was significantly associated with the incidence of RT-BOOP syndrome in a univariate analysis (p =0.023). The type of treatment (BCS or PMRT) and irradiated lung volume at 20 Gy (V20) were not significantly associated with the incidence of RT-BOOP syndrome in the entire patient cohort. In the multivariate analysis, age and smoking were the significant factor associated with RT-induced BOOP syndrome (p =0.044 and 0.049, respectively). RT-BOOP syndrome was a rarity, and the incidence for BCT cases was similar to that for PMRT cases. The irradiated lung volume was not significantly associated with RT-BOOP syndrome. An older age can predict the incidence of RT-BOOP syndrome

  11. Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation.

    Science.gov (United States)

    Williams, Kirsten M; Cheng, Guang-Shing; Pusic, Iskra; Jagasia, Madan; Burns, Linda; Ho, Vincent T; Pidala, Joseph; Palmer, Jeanne; Johnston, Laura; Mayer, Sebastian; Chien, Jason W; Jacobsohn, David A; Pavletic, Steven Z; Martin, Paul J; Storer, Barry E; Inamoto, Yoshihiro; Chai, Xiaoyu; Flowers, Mary E D; Lee, Stephanie J

    2016-04-01

    Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT) is associated with high mortality. We hypothesized that inhaled fluticasone, azithromycin, and montelukast (FAM) with a brief steroid pulse could avert progression of new-onset BOS. We tested this in a phase II, single-arm, open-label, multicenter study (NCT01307462). Thirty-six patients were enrolled within 6 months of BOS diagnosis. The primary endpoint was treatment failure, defined as 10% or greater forced expiratory volume in 1 second decline at 3 months. At 3 months, 6% (2 of 36, 95% confidence interval, 1% to 19%) had treatment failure (versus 40% in historical controls, P < .001). FAM was well tolerated. Steroid dose was reduced by 50% or more at 3 months in 48% of patients who could be evaluated (n = 27). Patient-reported outcomes at 3 months were statistically significantly improved for Short-Form 36 social functioning score and mental component score, Functional Assessment of Cancer Therapies emotional well-being, and Lee symptom scores in lung, skin, mouth, and the overall summary score compared to enrollment (n = 24). At 6 months, 36% had treatment failure (95% confidence interval, 21% to 54%, n = 13 of 36, with 6 documented failures, 7 missing pulmonary function tests). Overall survival was 97% (95% confidence interval, 84% to 100%) at 6 months. These data suggest that FAM was well tolerated and that treatment with FAM and steroid pulse may halt pulmonary decline in new-onset BOS in the majority of patients and permit reductions in systemic steroid exposure, which collectively may improve quality of life. However, additional treatments are needed for progressive BOS despite FAM. PMID:26475726

  12. A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

    Directory of Open Access Journals (Sweden)

    Kastelijn Elisabeth A

    2011-11-01

    Full Text Available Abstract Background Caveolin 1 (Cav-1 is the primary structural component of cell membrane invaginations called 'caveolae'. Expression of Cav-1 is implicated in the pathogenesis of pulmonary fibrosis. Genetic polymorphisms in the CAV1 gene influence the function of Cav-1 in malignancies and associate with renal allograft fibrosis. Chronic allograft rejection after lung transplantation, called 'bronchiolitis obliterans syndrome' (BOS, is also characterised by the development of fibrosis. In this study, we investigated whether CAV1 genotypes associate with BOS and whether Cav-1 serum levels are influenced by the CAV1 genotype and can be used as a biomarker to predict the development of BOS. Methods Twenty lung transplant recipients with BOS (BOSpos, ninety without BOS (BOSneg and four hundred twenty-two healthy individuals donated DNA samples. Four SNPs in CAV1 were genotyped. Serial Cav-1 serum levels were measured in a matched cohort of 10 BOSpos patients and 10 BOSneg patients. Furthermore, single-time point Cav-1 serum levels were measured in 33 unmatched BOSneg patients and 60 healthy controls. Results Homozygosity of the minor allele of rs3807989 was associated with an increased risk for BOS (odds ratio: 6.13; P = 0.0013. The median Cav-1 serum level was significantly higher in the BOSpos patients than in the matched BOSneg patients (P = 0.026. Longitudinal analysis did not show changes in Cav-1 serum levels over time in both groups. The median Cav-1 serum level in the group of 43 BOSneg patients was lower than that in the healthy control group (P = 0.046. In lung transplant recipients, homozygosity of the minor allele of rs3807989 and rs3807994 was associated with increased Cav-1 serum levels. Conclusion In lung transplant recipients, the CAV1 SNP rs3807989 was associated with the development of BOS and Cav-1 serum levels were influenced by the CAV1 genotype.

  13. Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved? Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: um mistério a ser resolvido?

    OpenAIRE

    Edvaldo Luiz Ramalli Jr; Leonardo Henrique Braga; Patricia Martinez Evora; Agnes Afrodite Sumarelli Albuquerque; Andrea Carla Celotto; André Lupp Mota; Paulo Roberto Barbosa Evora

    2011-01-01

    Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial port...

  14. [Arteriosclerosis--selected aspects].

    Science.gov (United States)

    Kucharska, Ewa

    2014-01-01

    The article summarizes the current knowledge concerning the diagnosis of atherosclerosis and therapeutic objectives. Atherosclerosis is one of the most common medical problems. It affects adults as well as children. It leads to clinically overt cardiovascular diseases (CVD), which are the cause of premature deaths. During its course, the formation of atherosclerotic plaque takes place, along with local inflammations artery walls. Gradually growing plaque does not cause clinical symptoms until the stenosis does not exceed 70-80% of the coronary vessel diameter, causing a marked reduction in blood flow to the heart muscle. The prevention of atherosclerosis and its complications requires an individual assessment of cardiovascular risk. In people without CVD symptoms, it is recommended to use SCORE risk card for Polish population, assessing the 10-year risk of cardiac death. A key element in combating atherosclerosis is to eliminate its risk factors by both implementing pro-health policies, as well as working with individual patients. An important objective is the proper control of blood pressure. It should not exceed 140/90 mmHg. A very important role is played by correct approach to patients with moderate or unusual cardiovascular risk. Despite knowing many facts about the mechanisms of atherosclerosis and its treatment, many issues still remain to be clarified. Finding methods to influence ongoing immune processes within arteries is of particular interest, which will soon make way to new therapeutic possibilities.

  15. Arteriosclerosis: facts and fancy.

    Science.gov (United States)

    Fishbein, Michael C; Fishbein, Gregory A

    2015-01-01

    Arterial vascular diseases comprise the leading cause of death in the industrialized world. Every physician learns about the pathology of these diseases in medical school. All pathologists evaluate arterial disease in surgical pathology and/or autopsy specimens. All clinicians encounter patients with clinical manifestations of these diseases. With such a common and clinically-important group of entities one would think there would be a general understanding of the "known" information that exists. That is, physicians and scientists should be able to separate what is fact and what is fancy. This review article is intended to generate thought in this regard.

  16. 下肢动脉硬化闭塞症患者股动脉粥样硬化斑块中巨噬细胞极化表型与自噬信号相关性的研究%Correlation between autophagy and polarization of macrophages in atherosclerosis plaque in arteriosclerosis obliterans amputees

    Institute of Scientific and Technical Information of China (English)

    陈文娜; 郭胜男; 王俊岩; 贾连群; 李大勇; 田英

    2016-01-01

    本文探讨了下肢动脉硬化闭塞症患者股动脉粥样硬化斑块中巨噬细胞自噬与极化的相互联系.取下肢动脉硬化闭塞症截肢患者的股动脉标本,分别行HE (hematoxylin and eosin)、油红O和免疫荧光染色,观察动脉粥样硬化斑块形态、斑块内巨噬细胞表型及自噬体表达;采用实时荧光定量RT-PCR技术检测动脉组织巨噬细胞M1与M2型标记物的mRNA表达水平;采用Western blot方法检测巨噬细胞极化信号通路及自噬蛋白表达水平.结果显示,动脉标本染色可见明显脂质沉积和大量泡沫细胞及炎性细胞浸润,纤维斑块以M1型巨噬细胞为主,粥样斑块M1与M2表型同时高表达,其中M2型巨噬细胞升高尤为显著,且粥样斑块自噬水平明显高于纤维斑块.纤维斑块组织肿瘤坏死因子α(TNF-α)、单核细胞趋化因子1(MCP-1)、诱导性—氧化氮合成酶(iNOS)、白细胞介素6 (IL-6)、白细胞介素12 (IL-12) mRNA表达水平均明显高于粥样斑块组织(P<0.01或0.05),而精氨酸酶1 (Arg-1)、转化生长因子β(TGF-β)、CD163及白细胞介素10 (IL-10)表达水平明显低于粥样斑块组织(P<0.01).纤维斑块组织p-STAT1及NF-κB表达水平显著升高(P<0.01),而粥样斑块组织p-STAT6表达显著升高(P<0.01),粥样斑块组织自噬体蛋白LC3-Ⅱ表达水平明显高于纤维斑块组织(P<0.01).研究提示早期动脉粥样硬化斑块中巨噬细胞通过p-STAT1/NF-κB通路诱导向M1型极化,表达适度的自噬水平;而晚期斑块中巨噬细胞则通过激活p-STAT6通路诱导向M2型极化的过渡,M2型巨噬细胞较M1型具有更高的自噬水平.

  17. 应用杂交技术治疗多节段下肢动脉硬化闭塞症34例%Application of hybrid technology for the treatment of multi segmental arteriosclerosis obliterans of lower limbs in 34 cases

    Institute of Scientific and Technical Information of China (English)

    赵晖; 邢壮杰; 郑新; 邓芝徽; 李润生; 郝国强

    2014-01-01

    目的:探讨杂交手术治疗复杂的多节段下肢动脉硬化闭塞症的临床效果。方法2008年1月至2013年4月,采用杂交手术(髂动脉支架植入联合股深动脉成形或股动脉-腘动脉人工血管旁路移植术)治疗下肢多节段动脉硬化闭塞治疗34例。34条患肢行髂动脉球囊扩张和支架植入术,其中21条患肢联合行股深动脉成形术,13条患肢联合行股-腘动脉旁路术。结果手术均获成功,无严重并发症,平均随访12个月(3~24个月)术后踝肱指数0.73与术前0.26相比显著提高(P<0.05)。结论杂交技术治疗复杂的多节段下肢动脉硬化闭塞症是一种安全有效的治疗方法。%Objective to study the treatment of hybrid operatiaon with multilevel atherosclerotic occlusive disease of the lower extremity. Methods from January 2008 to april 2013, hybrid operatiaon(intraoperative iliac Balloon angioplasty and stenting combined with vascular bypass and profundoplasty )were performed on 34 limb, suffering from lower extremity multilevel athcrosclcrotic occlusive disease. in 34 limbs iliac balloon angioplasty and stent placement were performed with profundoplasty in 21 limbs and femoro-popliteal bypass in 13 limbs. Results surgical procedures were technically successful in all limbs. there were no severe postoperative morbidity or mortality. Before-operative vs postoperative aBi was 0.26 vs 0.73 (P<0.05). the mean following-up period was 12months(range of 3 to 24 months). Conclusions Hybrid operatiaon are effective in the treatment of patients with multilevel atherosclerotic occlusive disease of the lower extremity.

  18. Associação de bronquiolite obliterante pós-infecciosa e hemossiderose pulmonar na infância Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood

    Directory of Open Access Journals (Sweden)

    Leonardo Araújo Pinto

    2006-12-01

    Full Text Available Descreve-se uma apresentação rara de bronquiolite obliterante associada a hemossiderose pulmonar, em paciente de nove anos com sintomas respiratórios persistentes iniciados após episódio de bronquiolite aguda grave aos sete meses. Após o episódio agudo, apresentou sintomas respiratórios persistentes, piorando significativamente aos sete anos, quando começou a apresentar dificuldade respiratória em pequenos esforços. A tomografia computadorizada de tórax demonstrou achados compatíveis com bronquiolite obliterante. A biópsia pulmonar a céu aberto demonstrou numerosos macrófagos corados com hemossiderina, além dos achados compatíveis com bronquiolite obliterante. O diagnóstico de hemossiderose pulmonar pode estar ocasionalmente associado a bronquiolite obliterante em crianças com seqüela pós-viral grave.In the present report, we describe an unusual presentation of post-infectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in a nine-year-old boy with persistent respiratory symptoms subsequent to an episode of acute bronchiolitis occurring at the age of seven months. After the episode, the persistent respiratory symptoms worsened significantly, and, by the age of seven, the patient began to have difficulty breathing after minimal exertion. Computed tomography of the chest presented findings consistent with bronchiolitis obliterans. Open lung biopsy revealed numerous hemosiderin-laden macrophages, as well as other findings consistent with bronchiolitis obliterans. Pulmonary hemosiderosis can occasionally be accompanied by bronchiolitis obliterans in children with severe sequelae after an episode of viral infection.

  19. 儿童闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎一例并文献复习%Bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review

    Institute of Scientific and Technical Information of China (English)

    韩青; 史彧; 李红霞; 唐文伟; 刘红霞; 赵德育

    2016-01-01

    目的 探讨闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎儿童临床-影像-病理学特点.方法 回顾1例南京医科大学附属南京儿童医院呼吸科2012-2013年收治的肺炎支原体肺炎后合并闭塞性细支气管炎伴机化性肺炎的儿童闭塞性支气管炎患儿临床诊治情况、影像学表现、组织病理学所见,并复习相关文献.结果 10岁女童,反复咳嗽、咯黄脓痰、不规则发热1个月,左下肺呼吸音低并有管状呼吸音;肺部影像示左下肺支气管扩张、扭曲,远端肺不张.纤维支气管镜见支气管黏膜滤泡增生,左下支气管亚段以下闭塞、痰栓.肺组织切面灰红、灰黄,局灶肉质变,管腔内少量黄色分泌物;镜下见肺组织纤维结缔组织增生、见泡沫细胞及Masson小体.肺炎支原体抗体IgM>1∶160.经红霉素等抗感染,纤维支气管镜灌洗后一度改善,但因病情反复最终行左肺切除,术后恢复良好.检索1990年1月-2016年1月CNKI中文数据库及PubMed,以“闭塞性支气管炎”与“闭塞性细支气管炎伴机化性肺炎”同时检索,没有检索到国内外任何文献.结论 闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎患儿表现为发热及呼吸道症状迁延不愈,肺部呼吸音低、管状呼吸音;肺炎支原体抗体阳性.影像学表现支气管扩张、远端肺不张.病理学检查可见肺纤维结缔组织增生、Masson小体.经肺叶切除病情好转.%Objective To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP).Method The clinical manifestations,characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed.Result A 10-year-old girl complained of recurrent paroxysmal cough and episodes of

  20. 肺移植后OB动物模型的研究进展%Progress on animal model of bronchiolitis obliterans after lung transplantation

    Institute of Scientific and Technical Information of China (English)

    康乐

    2014-01-01

    肺移植(lung transplantation,LT)已成为治疗终末期肺疾病患者生命的一个重要手段.细支气管闭塞综合征(bronchiolitis obliterans syndrome,BOS)作为LT术后的一种并发症广泛存在,其特征性病理表现为闭塞性细支气管炎(obliterative bronchiolitis,OB):细支气管周围有淋巴细胞浸润,最终导致纤维瘢痕的形成和细支气管闭塞.理想的动物模型有助于研究的进一步开展.目前,研究肺移植缺少一种理想的动物模型.了解肺移植后闭塞性细支气管炎的发病机制,有助于改善肺移植病人的生活质量,延长肺移植后患者生存率.本研究23将就肺移植后的闭塞性细支气管炎模型做一综述.

  1. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    ABSTRACT Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting ß2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. PMID:27383939

  2. Association between Serum Homocyteine and Coronary Arteriosclerosis%血清同型半胱氨酸与冠脉病变的相关性研究

    Institute of Scientific and Technical Information of China (English)

    郝应禄; 李燕萍; 杨娴; 钱宝堂; 余海; 谷青

    2011-01-01

    目的 探讨血清同型半胱氨酸(homocysteine,Hcy)水平与冠脉病变的相关性.方法 收集2010年8月至2011年9月于玉溪市人民医院心内科行冠状动脉造影的患者340例,分为冠心病组包括稳定性心绞痛(stable angina,SA)组、不稳定性心绞痛(unstable angina,UA)组、急性心肌梗死(acute myocardial infarction,AMI)组及正常对照组,所有入选对象均进行冠脉病变程度积分(Genesine积分)及血清Hcy水平测定.结果 (1)与对照组相比,冠心病组(包括SA、UA及AMI组)血清Hcy水平显著升高(P<0.Ol),与SA组相比,UA组、AMI组血清Hcy水平显著升高(P<0.01),与UA组相比,AMI组血清Hcy水平显著升高(P<0.01); (2)多元逐步线性回归分析及二元Logistic回归分析显示,除外性别、年龄、血糖、血脂等因素,血清Hcy仍与冠脉病变的严重程度相关,与斑块的不稳定性相关; (3) ROC曲线分析显示血清Hcy鉴别斑块不稳定性的敏感性和特异性优于低密度脂蛋白胆固醇(LDL-C)及Genesini积分.结论 血清Hcy与冠脉病变严重程度相关,且随着斑块不稳定性的增加,其水平逐渐增加.%Objective To investigate the association between serum homocyteine ( Hcy) and coronary arteriosclerosis. Methods 340 patients in our hospital who had cronary anginography were divided into 4groups: stable angina (SA) group, unatable angina (UA) group, acute myocardial infarction (AMI) group and control group. Gensine score and the level of serum Hey were determinated in all cases. Results (1) Compared with control group, the serum Hey levels were significantly higher in all groups with coronary heart desease (P< 0.01) , increased in -UA group and AMI group than that of SA group (P< 0.01), higher in AMI group than that of UA group (P<0.01). (2) Mutiple stepwise linear regression analysis and Logistic regression analysis showed that after controlling the effects of sex, age, blood glucose, blood fat, etal, serum Hey was still

  3. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-γ+CD4+ regulatory T cells to control transplant arteriosclerosis.

    Science.gov (United States)

    Hsu, Wan-Tseng; Lin, Cheng-Hsin; Chiang, Bor-Luen; Jui, Hsiang-Yiang; Wu, Kenneth Kun-Yu; Lee, Chii-Ming

    2013-03-01

    Mesenchymal stem cells (MSCs) are known for their immunomodulatory functions. We previously demonstrated that bone marrow-derived MSCs effectively control transplant arteriosclerosis (TA) by enhancing IL-10(+) and IFN-γ(+) cells. The objective of this study is to elucidate the mechanism by which MSCs induce IL-10(+)IFN-γ(+)CD4(+) regulatory T type 1 (T(R)1)-like cells. In an MLR system using porcine PBMCs, MSC-induced IL-10(+)IFN-γ(+)CD4(+) cells, which confer resistance to allogeneic proliferation in an IL-10-dependent manner, resemble T(R)1-like cells. Both cyclooxygenase-derived PGE(2) and IDO help to induce T(R)1-like cells by MSCs. MSCs constitutively secrete PGE(2), which is augmented in allogeneic reactions. However, T(R)1-like cells were deficient in PGE(2) and 4-fold less potent than were MSCs in suppressing MLR. PGE(2) mimetic supplements can enhance the immunosuppressive potency of T(R)1-like cells. In a porcine model of allogeneic femoral arterial transplantation, MSC-induced T(R)1-like cells combined with PGE(2), but not either alone, significantly reduced TA at the end of 6 wk (percentage of luminal area stenosis: T(R)1-like cells + PGE(2): 11 ± 10%; PGE(2) alone: 93 ± 8.7%; T(R)1-like cells alone: 88 ± 2.4% versus untreated 94 ± 0.9%, p < 0.001). These findings indicate that PGE(2) helps MSC-induced IL-10(+)IFN-γ(+)CD4(+) T(R)1-like cells inhibit TA. PGE(2) combined with MSC-induced T(R)1-like cells represents a new approach for achieving immune tolerance.

  4. Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.

    Science.gov (United States)

    Tang, Song-tao; Su, Huan; Zhang, Qiu; Tang, Hai-qin; Wang, Chang-jiang; Zhou, Qing; Wei, Wei; Zhu, Hua-qing; Wang, Yuan

    2016-01-01

    The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin light-chain phosphorylation (p-MLC) system via the mitogen-activated protein kinase (MAPK) signaling pathway or by suppressing the myosin phosphatase-targeting subunit phosphorylation (p-MYPT)/p-MLC system in diabetes mellitus (DM). Rats were randomly divided into 4 groups, including control, high-fat diet, DM, and DM + melatonin groups. Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks. The DM significantly increased the serum fasting blood glucose and lipid levels, as well as insulin resistance and endothelial dysfunction, which were attenuated by melatonin therapy to various extents. Importantly, the aortic endothelial permeability was significantly increased in DM rats but was dramatically reversed following treatment with melatonin. Our findings further indicated that hyperglycemia and hyperlipidemia enhanced the expressions of MLCK, p-MYPT, and p-MLC, which were partly associated with decreased membrane type 1 expression, increased extracellular signal-regulated kinase (ERK) phosphorylation, and increased p38 expression. However, these changes in protein expression were also significantly reversed by melatonin. Thus, our results are the first to demonstrate that the endothelial hyperpermeability induced by DM is associated with increased expressions of MLCK, p-MYPT, and p-MLC, which can be attenuated by melatonin at least partly through the ERK/p38 signaling pathway.

  5. Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.

    Science.gov (United States)

    Tang, Song-tao; Su, Huan; Zhang, Qiu; Tang, Hai-qin; Wang, Chang-jiang; Zhou, Qing; Wei, Wei; Zhu, Hua-qing; Wang, Yuan

    2016-01-01

    The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin light-chain phosphorylation (p-MLC) system via the mitogen-activated protein kinase (MAPK) signaling pathway or by suppressing the myosin phosphatase-targeting subunit phosphorylation (p-MYPT)/p-MLC system in diabetes mellitus (DM). Rats were randomly divided into 4 groups, including control, high-fat diet, DM, and DM + melatonin groups. Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks. The DM significantly increased the serum fasting blood glucose and lipid levels, as well as insulin resistance and endothelial dysfunction, which were attenuated by melatonin therapy to various extents. Importantly, the aortic endothelial permeability was significantly increased in DM rats but was dramatically reversed following treatment with melatonin. Our findings further indicated that hyperglycemia and hyperlipidemia enhanced the expressions of MLCK, p-MYPT, and p-MLC, which were partly associated with decreased membrane type 1 expression, increased extracellular signal-regulated kinase (ERK) phosphorylation, and increased p38 expression. However, these changes in protein expression were also significantly reversed by melatonin. Thus, our results are the first to demonstrate that the endothelial hyperpermeability induced by DM is associated with increased expressions of MLCK, p-MYPT, and p-MLC, which can be attenuated by melatonin at least partly through the ERK/p38 signaling pathway. PMID:25944844

  6. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    Directory of Open Access Journals (Sweden)

    JUAN I. VARGAS RT.

    2003-01-01

    Full Text Available Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP, sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativa. Se trató con prednisona con buena respuesta. Al octavo mes de tratamiento, mientras se disminuía la dosis de esteroides, comenzó con disnea y tos y aparición de nuevas opacidades pulmonares radiológicos, las que regresaron rápidamente al aumentar la dosis de esteroides. Discutimos las causas posibles de la recidiva de esta patología y su relación con la disminución de la dosis de esteroidesAlthough relapses are frequent in bronchiolitis obliterans organizing pneumonia (BOOP, there is scant information regarding the causes underlying its occurrence. We report a 63 year old woman with clinical and radiological features compatible with BOOP. No underlying cause was identified so she was thought to have cryptogenic BOOP or cryptogenic organizing pneumonia (COP. A transbronchial lung biopsy demonstrated chronic organizing pneumonia and features of proliferative bronchiolitis. She was successfully treated with prednisone. On the eighth month of steroid therapy, while tapering the dose, she begun with cough and dyspnea and developed new lung infiltrates on the chest x-ray film. The infiltrates cleared rapidly after increasing the dose of steroids. We discuss the possible causes of relapse in BOOP and its relation to steroid therapy

  7. Study of Pathogenesis and Psychological Factors of Heart Disease of Coro nary Arteriosclerosis%冠状动脉硬化性心脏病的发病机理与心理因素的探讨

    Institute of Scientific and Technical Information of China (English)

    卜力

    2001-01-01

    Coronary arteriosclerosis is the most common cause of de ath.The author reviewed many articles concerning the etiological risk factorts of this disease ,and based on the author's own experiences and view points,and then summarized t he pathogenesis and etiological risk factors of the diseases as follows:①life e vents;②charactors of personality-type A of behaviour;③negative mood;④Diet;⑤B ad addictions.Well treatment of these factors is effective orientations and meth ods for prevention of coronary arteriosclerosis.%冠心病为死亡原因最高的疾病,探究其发病机理为预防此病的要旨。 作者复习了有关 此病的文献,加上作者自己对它的经验体会,加以阐述。其发病机理与危险因素有下列诸点 :①生活事件;②A型行为类型;③负性情绪;④饮食因素;⑤不良嗜好。根据这些因素采 取积极措施,为预防此病的主要方向。

  8. Serum Krebs Von Den Lungen-6 as a Biomarker for Early Detection of Bronchiolitis Obliterans Syndrome in Children Undergoing Allogeneic Stem Cell Transplantation.

    Science.gov (United States)

    Gassas, Adam; Schechter, Tal; Krueger, Joerg; Craig-Barnes, Hayley; Sung, Lillian; Ali, Muhammad; Dell, Sharon; Egeler, R Maarten; Zaidman, Irina; Palaniyar, Nades

    2015-08-01

    Bronchiolitis obliterans syndrome (BOS) is a devastating complication after allogeneic stem cell transplantation (allo-SCT). Early identification of high-risk patients is pivotal for success. Lung proteins, KL-6, CCSP, SP-A, and SP-D, measured in the serum may identify high-risk patients for BOS earlier than pulmonary function tests (PFTs) can identify changes or clinical symptoms. Lung proteins were measured in patients' serum at baseline and at 1, 3, 6, 9, 12, 18, and 24 months after transplantation along with history, clinical examination, and PFTs. Serum levels of lung proteins were also measured in healthy control subjects. The primary endpoint was the development of BOS confirmed by pathological biopsy or National Institutes of Health criteria. Between September 2009 and September 2011, 39 patients were enrolled. Six children developed BOS at a median time of 200 days (range, 94 to 282). KL-6 levels were low in control subjects, at a median of .1 U/mL (range, .1 to 1.5). Pre-SCT and 1-month KL-6 levels were significantly higher in surviving patients who developed BOS (n = 6) versus those who did not (n = 18) (pre-SCT: mean, 32.6 U/mL [IQR, 9.7 to 89.3] versus 5.8 U/mL [IQR, 2.1 to 12.6], P = .03; at 1 month: mean, 52.5 U/mL [IQR, 20.2 to 121.3] versus 11.4 U/mL [IQR, 5.7 to 36.0], P = .04). Three- and 6-month KL-6 levels continued to be higher in BOS group but were not statistically significant. CCSP, SP-A, and SP-D were not predictive. KL-6 measured in the serum of children receiving allo-SCT may identify patients at high risk for the development of BOS. These patients will benefit from intensive surveillance protocol and early therapy before irreversible lung damage. PMID:25963919

  9. Application of early diagnosis for arteriosclerosis by using cardio-ankle vascular index%心踝血管指数早期筛查动脉硬化的应用价值

    Institute of Scientific and Technical Information of China (English)

    胡华青; 叶良平; 刘宁徽; 赵静; 韩卫星

    2012-01-01

    目的 对心踝血管指数(CAVI)早期筛查动脉硬化的有效性、适用性进行探讨,旨在寻求早期发现动脉粥样硬化性疾病的有价值的检测方法.方法 对229例同时行CAVI检测和颈动脉超声检测的体检人群进行分析,并对相关检测结果 进行统计学分析.结果 CAVI增高和颈动脉硬化呈正相关;通过受试者工作特征曲线(ROC曲线)分析CAVI对动脉硬化的预测价值,结果 显示CAVI预测动脉硬化的ROC曲线下面积为0.774,最佳界值为8.1;将年龄分组后,在40~49岁年龄组CAVI阳性率高于颈动脉超声(P<0.05);在<40岁以及>50岁年龄组,二者阳性率差异无统计学意义.结论 CAVI是一种有效的早期评估动脉粥样硬化的检测指标,适用于在发生动脉硬化的早期或对于危险人群进行筛查;CAVI达8.1以上时就可能已有血管功能改变发生,应予 以足够重视,将有利于早期发现血管病变,预防血管疾病突发事件的发生.%Objective To investigate the suitability and effectiveness of early diagnosis of arteriosclerosis by using cardio-ankle vascular index ( CAVI) , and to find out the valuable methods of early diagnosis for atherosclerosis . Methods 229 cases of health -care examination were recruited in our study. Statistic analysis was taken on relevant results of examination. Results Carotid atherosclerosis was positively correlated with CAVI. To analyze CAVI predictive value of arteriosclerosis through ROC curve , the area under the curve was 0. 774, and the best cut-off value to predict arteriosclerosis was 8. 1 Subjects were separated into different groups according to the age . The positive rates of CAVI were higher than that of carotid ultrasonography in group from 40 to 49 years old ( P < 0. 05 ) The difference between positive rates of CAVI and carotid ultrasonography were no statistic value in groups of younger than 40 years old and older than 50 years old. Conclusion CAVI is an effective

  10. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans.

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting 2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. RESUMO A bronquiolite obliterante pós-infecciosa (BOPI) é uma doença das pequenas vias aéreas caracterizada por limitação fixa do fluxo aéreo. Portanto, os broncodilatadores e os corticosteroides inalatórios não são recomendados como opções de terapia de manutenção. Atualmente, o manejo da BOPI consiste apenas de um acompanhamento rigoroso dos pacientes afetados, visando à prevenção e ao tratamento precoce de infecções pulmonares. A incidência de BOPI tem aumentado na população pediátrica nos últimos anos. Os pacientes com BOPI caracterizam-se por um declínio progressivo da função pulmonar, associado a uma diminuição da capacidade funcional global. Relatamos aqui o caso de um homem relativamente jovem diagnosticado com BOPI, acompanhado por três anos. Ap

  11. Pharmaceutical Care for One Elderly Patient with Acute Bronchitis Associated with Cerebral Arteriosclerosis%1例老年急性支气管炎并脑动脉硬化患者的药学监护

    Institute of Scientific and Technical Information of China (English)

    张富东

    2014-01-01

    目的:探讨临床药师参与药物治疗方案的制订与药学监护的方法。方法:介绍临床药师参与1例老年急性支气管炎并脑动脉硬化患者的治疗过程,分析、评价治疗方案,提出药学建议,并进行药学监护。结果:通过药师的介入与参与可使患者的治疗更加顺利,真正做到了对老年急性支气管炎并脑动脉硬化患者的治疗个体化,使患者顺利治愈出院。结论:临床药师的参与可以协助医师制订安全、有效的治疗方案。%OBJECTIVE:To explore the approaches for clinical pharmacist to participate in the formulation of treatment regi-men and carry out pharmaceutical care. METHODS:Clinical pharmacist’involvement in the treatment of one elderly patient with acute bronchitis associated with cerebral arteriosclerosis was introduced with regard to his efforts in analyzing and evaluating thera-peutic regimen,putting forward pharmacy suggestion and providing pharmaceutical care. RESULTS:Pharmacist’s involvement con-tributed to smooth treatment of the patient and effectuated the individualized treatment for the elderly patient with acute bronchitis associated with cerebral arteriosclerosis and the patient was cured and discharged from hospital. CONCLUSIONS:Clinical pharma-cist’s involvement can help clinical physicians in formulating safe and effective treatment regimen.

  12. 超声检查右锁骨下动脉对早期动脉粥样硬化的临床价值%Value of Ultrasound Detection of Right Subclavian Artery in Early Diagno-sis of Arteriosclerosis and Attitude to Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    贾慧霞; 张建宾; 金蓉

    2016-01-01

    Objective To search the parts of the arteriosclerosis by using high-resolusion Doppler Ultrasonography on 428 patients of more than 40 years with carotid and right subclavian atherosclerosis patch. Methods High-resolusion Doppler Ultrasonography was used to scan carotid artery and the initial right subclavian artery to observe the pathologic structures. Results 1. Elderly patient,age of 40~49,carot-id atherosclerosis patch incidence rate is 22. 9%,which was the lowest rate. Otherwise,the highest one was age≥70,94%. And detectable rate of arteriosclerosis patch was increased by age. 2. Patients in group of age 40~49:the detectable rate of arteriosclerosis patch at initial part of right subclavian artery were lower than the detectable rates of arteriosclerosis patch at bifurcation of common carotid artery(P﹤0. 01). 3. In group of age 50~59,patients who was detected arteriosclerosis patch on both initial part of right subclavian artery and the bifurcation of common carotid artery,the thickness of arteriosclerosis at initial part of right subclavian ar-tery were thicker than the thickness of arteriosclerosis at the bifurcation of common carotid artery(P﹤0. 05). Conclusion The arteriosclerosis firstly occurred in the initial part of right subclavian artery. The thickness of arteriosclerosis patch at initial part of right subclavian artery is thicker than bifurcation of common carotid artery among the patients in group of age 40~59.%目的:通过对428例40岁以上受试者颈动脉及锁骨下动脉动脉粥样硬化性病变(以下简称为病变)的彩色多普勒超声诊断,探讨动脉斑块早期好发部位。方法采用彩色多普勒超声对428例受试者进行双侧颈动脉及右锁骨下动脉起始处进行探测,观察病变的有无、发生部位、发生时间。结果年龄在40~49组病变检出率最低,约为29.9%,而≥70岁组检出率最高约为94.0%,年龄与病变检出率之间存在正相关关系。40~49岁受试

  13. 膝以下动脉硬化闭塞症的介入治疗%Treatment and Research of Arteriosclerosis Obliterians for Infrapopliteal Arteries

    Institute of Scientific and Technical Information of China (English)

    张宇; 张志伟; 吴继东; 刘宏; 赵京; 李新宇

    2013-01-01

    Objective:To investigate the approaches , nodi, therapies of complications and prognosis of endovascular treatment for patients with infrapopliteal arteries arteriosclerosis obliterians ( ASO) .Methods:We conducted endovascular treatment for 72 patients ( 84 limbs ) between January 2008 and December 2012 and punctured femoral artery antegrade or retrograde , made lower extremity artery angiography , then used guide wire and catheter getting through the artery stenosis or occlusion .If failed, subintimal angioplasty was tried .Balloon was introduced with guiding wire to dilatating the vascular .After expansion , artery angiography was made to e-valuate if there existed residual stenosis , when residual stenosis was greater than 30%, tried again .If arterial dissection occurred , drug-coated stent was implanted .Results:84 limbs underwent endovascular treatment and 82 achieved angiographic success with 97.6%clinical success rate .16 cases with intermittent claudication in-creased claudicating distance of 500 m (50-2 500 m), resting pain of 43 cases lightened or disappeared , toe ulcer of 8 cases healed with dressing change after 3 months, 1 toe ulcer case autologous saphenous vein bypass because of in-stent thrombosis.3 cases with toe gangrene took operations and the wound healed in 3 months.1 case with anterior half foot gangrene took below -knee amputation .Conclusions:Endovascular treatment is a safe and effective method for infrapopliteal arteries ASO , and which can be repeated , achieve a high clinical success rate with a low complication rate and a high limb salvage rate .%目的:探讨膝以下动脉硬化闭塞症腔内治疗的方法、难点、并发症处理以及预后。方法:2008年1月至2011年12月,采用介入方法治疗膝以下动脉硬化闭塞症72例(84条肢体)。采取股总动脉顺行或逆行穿刺,下肢动脉造影,以导丝配合导管通过动脉狭窄段,或开通动脉闭塞段;开通失败者,尝试内膜下

  14. The Clinical Research of Gegen Qinlian Decoction in Treating with Carotid Arteriosclerosis Pa-tientsSleeping Quality%葛根芩连汤对颈动脉硬化患者睡眠质量影响的研究

    Institute of Scientific and Technical Information of China (English)

    黄小波; 王宁群; 陈玉静; 吴犀翎; 陈文强

    2014-01-01

    Objective To research the difference of diazepam and Gegen Qinlian Decoction in treating with carotid ar-teriosclerosis patientsinsomnia.Methods 112 carotid arteriosclerosis patients were divided into two groups.One group was treated with diazepam,and the other group was treated with Gegen Qinlian Decoction.Patients in both groups were treated for 6 weeks.And their sleeping qualities were estimated by Pittsburgh Sleep Quality Index (PSQI);the side effects were estimated by Treatment emergent symptoms scale (TESS).Results Diazepam could significantly improve patientssleeping quality,sleeping time and total score.And Gegen Qinlian Decoction could significantly improve patientssleeping quality,sleeping time,sleeping effective,sleeping pill,day function and total score.Compared with diazepam,Gegen Qinlian Decoction could significantly im-prove patientssleeping quality,sleeping effective,sleeping pill,day function and total score;and had fewer side effects.Conclu-sion Chinese medicine gave much attention to carotid arteriosclerosis insomnia patientsspecial physiological character,and Chi-nese medicine could adjust personsyin and yang,based on their total body.So,Chinese medicine had a better clinical effective in improving aged insomnia patientssleeping quality.%目的:分别使用葛根芩连汤和安定对颈动脉硬化失眠患者进行治疗,研究两者在改善患者睡眠质量方面的差异。方法将112例颈动脉硬化失眠症患者随机分为2组,治疗组给予葛根芩连汤,对照组给予安定2.5 mg,共治疗6周。采用《匹兹堡睡眠质量指数量表》(PSQI)评定睡眠质量;《治疗副反应量表》(TESS)评定药物干预后出现的不良反应。结果安定组患者睡眠质量,入睡时间及 PSQI 总分均有显著改善。葛根芩连汤组患者睡眠质量,入睡时间,睡眠效率,安眠药物,日间功能及总分均较治疗前有极显著改善。与安定组比较,葛

  15. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM"O"P)

    Science.gov (United States)

    Crestani, B; Valeyre, D; Roden, S; Wallaert, B; Dalphin, J C; Cordier, J F

    1998-12-01

    Reports of bronchiolitis obliterans organizing pneumonia (BOOP) occurring in women after radiation therapy for breast cancer have suggested that radiation to the lung could participate in the development of BOOP. We now describe the clinical, radiographic, functional, and bronchoalveolar lavage characteristics of this syndrome in a series of 15 patients reported to the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P) in France. All 15 women (60 +/- 6 yr of age) fulfilled the following inclusion criteria: (1) radiation therapy to the breast within 12 mo, (2) general and/or respiratory symptoms lasting for at least 2 wk, (3) lung infiltrates outside the radiation port, and (4) no specific cause. The patients presented with fever, nonproductive cough, mild dyspnea, and peripheral alveolar opacities on chest radiograph with a characteristic migratory pattern. In five patients, BOOP was found at lung pathologic analysis. In all the patients dramatic improvement was obtained with corticosteroids, but relapses occurred in 12 patients while tapering or after stopping corticosteroids. This report demonstrates that a characteristic BOOP syndrome may occur after radiation therapy to the breast, including tangential radiation to the lung, thus suggesting that radiation therapy may prime the development of BOOP.

  16. Applications of TCD assay in detection on cerebral arteriosclerosis of hypertensive patients%经颅多普勒超声在高血压患者脑动脉硬化检测中的应用

    Institute of Scientific and Technical Information of China (English)

    韩莉莉

    2012-01-01

    目的 研究健康体检中高血压患者脑动脉硬化经颅多普勒(TCD)检测的应用.方法 回顾性分析2010年7月~2011年7月在开封市第一人民医院体检科进行健康体检中高血压患者1 055例TCD检测结果及相关临床资料(年龄、性别、临床诊断、遗传病史等),研究TCD改变与临床的关系,为血压增高者的脑血管功能学评价提供客观血流动力学资料.结果 进行TCD检查的1 055例被检者中,脑动脉硬化频谱改变518例;颈内动脉系统单支或多支血管收缩期血流速度增高703例,其中,涡流及湍流54例;收缩期血流速度减低16例;椎基底动脉系统收缩期血流速度增高599例、减低8例.由统计学分析可知,除在男70~90岁组、女60~组外,余病例组动脉硬化检出率均高于对照组,差异具有统计学意义.在去除年龄因素的作用后,可认为男、女高血压患病均与动脉硬化有关(CMH x 男2=52.384,x 女2=13.747,均P<0.001);另ORMH 男=2.861,ORMH 女=1.718,说明男性高血压患者发生脑动脉硬化的优势比为2.861、女性高血压患者发生脑动脉硬化的优势比为1.718.TCD检测异常率高于被检者对相关疾病的知晓率.结论 TCD检测可较灵敏地反映高血压时脑血管的血流动力学改变,在高血压患者脑动脉硬化的血管功能学评价及指导临床治疗中具有重要意义.%OBJECTIVE To investigate the applications of TCD detection in physical examination of cerebral arteriosclerosis of hypertensive patients. METHODS We reviewed and analyzed the 1 055 samples of hypertension patients in Health Examination Department of Kaifeng First People's Hospital with their TCD inspected results and clinical data including of age, gender, clinical diagnosis and genetic disease from July 2010 to July 2011. Then we investigated the relationship between changes of TCD and clinical phenomenons to provide objective hemodynamic data of cerebral vascular functional

  17. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    International Nuclear Information System (INIS)

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 ± 6.4 HU vs 26.1 ± 6.5 HU; P 25-75, (γ = -0.68-0.88, P ≤ 0.002). Volume percentages of xenon ventilation defects (35.0 ± 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 ± 18.6%). However, mismatches between the volume percentages were variable up to 21.4-33.3%. Mean effective dose of xenon CT was 1.9 ± 0.5 mSv. In addition to high-resolution anatomic information, xenon ventilation CT using dual-source and dual-energy technique demonstrates impaired regional ventilation and its heterogeneity accurately in children with BO without additional radiation exposure. (orig.)

  18. Arterialização do arco venoso do pé para tratamento da tromboangeíte obliterante Arterialization of the venous arch of the foot for the treatment of thromboangiitis obliterans

    Directory of Open Access Journals (Sweden)

    Cesar Roberto Busato

    2008-09-01

    Full Text Available Em isquemia crítica sem leito arterial distal, um dos modos de irrigar o membro isquêmico é derivar o fluxo de maneira retrógrada através do sistema venoso. As primeiras tentativas de fístulas arteriovenosas terapêuticas datam do início do século passado. Realizadas na parte proximal dos membros inferiores, não obtiveram resultados favoráveis. A partir da década de 70, com os trabalhos pioneiros de Lengua, as fístulas passaram a ser estendidas até o pé, e os bons resultados apareceram em várias publicações. Os autores relatam a evolução de um caso de tromboangeíte obliterante submetida ao procedimento. Essa é uma cirurgia de indicação precisa, que requer estudo pré-operatório arterial e venoso e observância a detalhes de técnica operatória.In critical ischemia without arterial run-off, it is possible to irrigate the ischemic limb by turning the course of the flow reversely through the venous system. The first experiments with therapeutic arteriovenous fistulas date from the beginning of the last century. They were performed in the proximal area of the lower limbs, but showed unfavorable results. Since the 1970's, with the pioneer studies of Lengua, fistulas started being extended to the foot and several publications have reported good outcomes. The authors report the evolution of a case of thromboangiitis obliterans which was submitted to the procedure. This is an accurate surgical procedure which requires arterial and venous preoperative study and the observance of technical operative details.

  19. 亚高原地区高血压与外周动脉硬化相关性探讨%Correlation between hypertension and peripheral arteriosclerosis in people from sub-plateau

    Institute of Scientific and Technical Information of China (English)

    李丽娟; 李琼; 魏玲

    2011-01-01

    目的 探讨亚高原城镇人群高血压与外周动脉硬化的相关性.方法 随机从2009年10月~2010年4月昆明城镇企事业单位到我院体检的18岁以上人群中,抽取检出血压异常且符合高血压诊断标准的受检者1000名作为高血压组,同时随机抽取673名体检提示血压正常者作为对照组,采用日本科林公司生产的VP-1000全自动测量仪对两组患者作肱踝脉搏波传导速度(baPWV)及踝臂指数(ABI)测量.结果 高血压组baPWV值明显高于对照组(P<0.01),ABI≤0.9检出率明显高于对照组(P<0.01).结论 亚高原地区城镇人群高血压与动脉硬化密切相关,选择对动脉僵硬度有影响的降压药物,有效控制血压,同时指导患者进行间断性适量的有氧运动,对预防及延缓高血压靶器官损害及心血管事件的发生,延长患者寿命具有重要意义.%Objective To investigate the correlation between hypertension and peripheral arteriosclerosis in people from sub -plateau towns. Methods Among subjects( above 18 years old )from enterprise or government units in Kunming City receiving physical examination in our hospital from October 2009 to April 2010,1000 ones who met the diagnostic criteria of hypertension were randomly selected and served as hypertension group. Another 673 ones with normal blood pressure were randomly selected as control group. The brachial ankle pulse wave velocity( baPWV )and ankle brachial index( ABI )of all subjects were detected by the Japanese Colin VP -1000 automatic measuring instrument. Results Both baPWV and the detection rate of ABI ^ 0. 9 in the hypertension group were significantly higher than those in the control group( P < 0. 01 ). Conclusion There is a close correlation between hypertension and arteriosclerosis in people from the sub - plateau towns. Antihypertensive drugs that can affect the arterial stiffness should be chosen to control peoples blood pressure. Moreover, they should be guided to take

  20. 308例老年高血压病患者动脉硬化检测结果分析%Analysis of Examination Results of Arteriosclerosis of 308 High Blood-pressure Senior Patients

    Institute of Scientific and Technical Information of China (English)

    黄雯; 曾小茹; 莫发敏

    2013-01-01

    目的:了解老年高血压病患者动脉硬化情况。方法:随机抽取到本院门诊就诊或住院的老年高血压病患者308例进行动脉硬化检测,测定其肱踝脉搏波传导速度(baPWV)及踝臂指数(ABI),将检测结果与同期到本院进行健康体检的100例老年健康人群进行比较分析。结果:(1)老年高血压病患者的baPWV显著高于健康对照组,ABI明显低于健康对照组。(2)高血压病患者随着血压分级的升高, baPWV依序升高,ABI依序降低。(3)并发冠心病或脑卒中的高血压病患者,baPWV显著高于无并发症者,ABI明显低于无并发症者。(4) baPWV重度异常组,同型半胱胺酸、高脂血症、并发冠心病或脑卒中、糖尿病、吸烟等危险因素明显高于baPWV轻度或中度异常组。结论:高血压是引起动脉硬化及动脉粥样硬化的独立危险因素;高血压病患者随着血压分级升高,动脉硬化程度加重;baPWV和ABI是冠心病或脑卒中的独立预测因子;高血压病患者危险因子越多,动脉硬化程度越重。%Objective:To understand the detail situation of arteriosclerosis with senior high blood-pressure patients.Method:308 cases of senior high blood-pressure patients were randomly selected from outpatients or hospitalized patients. Brachial ankle pulse wave velocity(baPWV)and anklearm index(ABI)were performed in all patients. The baPWV and ABI differences were compared between senior high blood-pressure patients and elderly healthy person,which were randomly selected from the physical examination branch physical exam in the same time.Result:(1)The baPWV values of senior high blood-pressure patients were significantly higher than that of the healthy group,while the ABI values of seniorhigh blood-pressure patients were obviously lower.(2)With the grade of blood pressure moving higher,The baPWV value of high blood-pressure patients went higher,while the ABI value

  1. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo; Yang, Dong Hyun; Seo, Joon Beom; Chae, Eun Jin; Lee, Jeongjin [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Songpa-gu, Seoul (Korea); Hong, Soo-Jong; Yu, Jinho; Kim, Byoung-Ju [University of Ulsan College of Medicine, Department of Pediatrics, Asan Medical Center, Seoul (Korea); Krauss, Bernhard [Siemens Medical Solutions AG-Computed Tomography, Forchheim (Germany)

    2010-09-15

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 {+-} 6.4 HU vs 26.1 {+-} 6.5 HU; P < 0.001) and CT density (-892.8 {+-} 25.4 HU vs -812.3 {+-} 38.7 HU; P < 0.001) values were significantly lower in hyperlucent regions than in normal lung regions. Xenon and CT density values showed significant positive correlation for the entire lung in 16 children ({gamma} = 0.55 {+-} 0.17, P < 0.001 or =0.017) and for hyperlucent regions in 13 children ({gamma} = 0.44 {+-} 0.16, P < 0.001 or =0.001-0.019). Indexed volumes and volume percentages of hyperlucent lung regions and ventilation defects showed strong negative correlations with forced expiratory volume [FEV1, ({gamma} = -0.64-0.85, P {<=} 0.006)], FEV1/forced vital capacity [FVC, ({gamma} = -0.63-0.84, P {<=} 0.008)], and forced midexpiratory flow rate [FEF{sub 25-75}, ({gamma} = -0.68-0.88, P {<=} 0.002). Volume percentages of xenon ventilation defects (35.0 {+-} 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 {+-} 18.6%). However, mismatches between the

  2. 人股动脉粥样硬化相关蛋白的鉴定及其生物学作用%Proteomics analysis on pathogenesis of human atherosclerosis obliterans in human femoral artery

    Institute of Scientific and Technical Information of China (English)

    赵振; 赵海光; 蒋米尔

    2011-01-01

    Objective We used proteomic profiling in an attempt to differentiate and identify histological proteins that were associated with atherosclerosis obliterans (ASO) of human femoral artery.Methods We comparatively analyzed the proteome of 8 atherosclerotic and 5 normal femoral arteries. The differentially expressed proteins were visualized by two dimensional electrophoresis (2-DE) and sequenced by matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS). The protein identification program was used to search the National Center for Biotechnology Information (NCBI) database and International Protein Index (IPI). Results A total of 53 distinct spots corresponding to 13 different proteins were identified by MALDI-TOF-MS using the NCBI and IPI databases. The function information of these 13 proteins mainly involved the pathogenetic mechanisms such as inflammation, innate immunity, oxidative stress, lipid metabolism, amyloid degeneration and so on. Conclusion ASO is associated with distinct patterns of protein expression in the femoral arteries, and differentially expressed 13 proteins may contribute to the pathogenesis. These findings might provide needed biomarkers for ASO and new insight into its pathophysiology.%目的 应用比较蛋白质组学方法探讨人动脉粥样硬化闭塞症(ASO)差异蛋白质的表达及其在ASO发病机制中的作用.方法 选取ASO股动脉8例及正常股动脉5例,提取组织蛋白质,行双向凝胶电泳分离、质谱分析及数据库查询,获得差异蛋白信息.结果 成功建立ASO和正常股动脉双向电泳图谱,含量相差大于2倍以上的蛋白质53个,27个上调,26个下调,质谱鉴定出13种蛋白质,主要与炎症、免疫、氧化应激、脂质代谢等相关.结论 ASO与正常股动脉蛋白质组明显差异,差异蛋白质可能在ASO中起重要作用.

  3. 彩色多普勒超声在下肢动脉粥样硬化诊断中的应用价值%The application value of Color Doppler ultrasound in diagnose of lower limb Arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    刘芳

    2012-01-01

      Objective To explore The application Value of the color Doppler ultrasound in lower limb arteriosclerosis diagnosis Methods From 2009 May to 2012 May in our hospital, color Doppler ultrasound in diagnosis of lower limb atherosclerosis clinical data, analyze the disease diagnosis application value. Results The color Doppler ultrasound can effectively monitor the treatment of lower limb atherosclerosis of lower extremity atherosclerosis, the wall thickness, arterial diameter and other aspects of the effective diagnosis. Conclusion Color Doppler ultrasound ( CDu ) has become the current noninvasive diagnosis of lower limb atherosclerosis is the preferred method, it is clearly in the two-dimensional display a vascular lesion of the anatomical changes, and by color Doppler flow imaging, provides a wealth of lower limb blood vessels in hemodynamic information.%  目的 探讨彩色多普勒超声在下肢动脉粥样硬化诊断中的应用价值。方法 总结2009年5月—2012年5月,该院彩色多普勒超声诊断下肢动脉粥样硬化的临床资料,分析并探讨其在本病诊断中的应用价值。结果 彩色多普勒超声能有效监测下肢动脉粥样硬化的治疗,对下肢动脉粥样硬化的壁厚度、动脉内径等方面进行了有效的诊断。结论 彩色多普勒超声(cDU)已成为了目前无创性检查下肢动脉粥样硬化的首选方法,它既清晰地在二维上显示了血管病变的解剖结构改变,又经过彩色多普勒的血流显像,提供了丰富的下肢血管内血流动力学的信息。

  4. Clinical Observation on Aerosol Inhalation Combined with Oral Corti Cos-teroids in Treatment of Bronchiolitis Obliterans in Children%雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床分析

    Institute of Scientific and Technical Information of China (English)

    薛斌

    2016-01-01

    Objective To discuss and observe the clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children. Methods 116 cases of children with bronchiolitis obliterans diagnosed from December 2010 to June 2015 were collected and randomly divided into two groups with 58 cases in each, the observation group were treated with budesonide inhalation aerosol and oral corti costeroids, the control group were also treated budes-onide inhalation aerosol and oral corti costeroids, but the dose was different, and the treatment effects and asthma control situations were compared. Results The effective rate and asthma control scale were respectively 93.1%and (23.4±1.2) marks in the observation group, which were obviously better than those in the control group, P<0.05. Conclusion The clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children is satisfactory.%目的:探讨雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床疗效。方法方便选取2010年12月—2015年6月确诊的116例闭塞性细支气管炎患儿,随机分为观察组(布地奈德雾化吸入和口服泼尼松)和对照组(同观察组,但剂量不同)各58例,比较治疗效果和哮喘控制情况。结果观察组有效率为93.1%,哮喘控制得分为(23.4±1.2)分,均明显优于对照组(P<0.05)。结论雾化吸入与口服糖皮质激素协同治疗儿童闭塞性细支气管炎临床效果满意。

  5. Subclinical arteriosclerosis screening. The PAP/PEA study. Prevalenza dell'Arteriosclerosi Precoce (Prevalence of Early Arteriosclerosis).

    Science.gov (United States)

    Belcaro, G; Geroulakos, G; Laurora, G; Cesarone, M R; de Sanctis, M T; Incandela, L; Barsotti, A; Nicolaides, A N

    1994-04-01

    Noninvasive screening of subclinical atherosclerosis is possible with ultrasonic biopsy (UB) performed with high resolution ultrasound scanning. Five UB classes have been identified, each class corresponding to a different incidence of cardiovascular events (CVE) in 4 years and silent coronary ischemia (SCI). In a study including 2230 asymptomatic subjects 3 risk groups were defined. In the low risk group (class I and II; 82.01% of the population sample) the incidence of CVE and SCI was zero. These subjects may be seen again after 3 years. In the moderate risk group (class II and IV; 13.3%) monitoring and early intervention may be needed. In the high risk group (class V; 4.6%) prophylaxis or treatment may be necessary. The screening is effective, simple and may be organised at very low cost--i.e. 30.000 asymptomatic subjects may be scanned at the cost of 100.000 ECU. Each scan, including carotid and femoral bifurcations, may be performed in 15 minutes. In our communities this cost is equivalent to the average cost of a single major stroke or major coronary ischemic event in a working adult aging between 45 and 60. Organization problems and the fragmentation of competences has prevented the evolution of atherosclerosis screening. The problem can be solved organising a network including epidemiologists, angiologists and cardiovascular surgical centres where all phases of atherosclerosis may be studied and detected, progression prevented and complications treated with a global vision of the disease. PMID:8195271

  6. Bronquiolite obliterante pós-infecciosa: aspectos clínicos e exames complementares de 48 crianças Post-infectious bronchiolitis obliterans: clinical aspects and complementary testing of 48 children

    Directory of Open Access Journals (Sweden)

    Rosaly Vieira dos Santos

    2004-02-01

    obliterans (BO is variable. OBJECTIVE: Substantiate the clinical characteristics, the evolution and the complementary tests of 48 patients with post infectious bronchiolitis obliterans (BO. METHOD: Observational and retrospective study. Diagnosis of BO was based upon clinical criteria, CT scan findings and exclusion of other diseases. History prior to diagnosis and complementary tests were evaluated as well as initial and final values of oxygen saturation. RESULTS: Mean age of patients at the acute stage of the infectious disease was of 9.6 Thirty two of the patients were male. All were hospitalized during the acute stage, 14 of them (29% in the ICU. Four patients died two years after onset of acute bronchiolitis. During evolution all required emergency care due to exacerbation of the pulmonary condition and 24 (50% were hospitalized, 2 of them in the ICU. The majority continued presenting cough, wheezing, crackles and hyperinflation, however to a lesser degree. Mean of initial arterial saturation was of 89% and final of 92%. The most common infectious agents in the sputum samples were H. influenzae, S. pneumoniae and M. caterrhalis. Increased serum IgM and IgG were found in 9 and 7 patients respectively. The most frequent findings at thorax CT scan were mosaic perfusion, bronchioectasis, atelectasis and bronchial wall thickening. CONCLUSION: Post infectious BO is a chronic and severe disease with persistent symptoms that in general affect infants. Positive serum cultures and increased serum immunoglobulins are suggestive of a chronic infectious inflammatory condition.

  7. Role of progenitor cells in transplant arteriosclerosis

    NARCIS (Netherlands)

    Hillebrands, JL; Onuta, G; Rozing, J

    2005-01-01

    To date, chronic transplant dysfunction (CTD) is recognized as the major cause of transplant loss long term after transplantation. CTD has the remarkable histologic feature that the luminal areas of the intragraft arteries become obliterated as a result of occlusive neointima formation. Neointimal l

  8. Analysis of risk factors related with carotid atherosclerotic arteriosclerosis in a Chinese young and middle-aged population who received health checkup%中青年体检人群颈动脉粥样硬化及相关危险因素

    Institute of Scientific and Technical Information of China (English)

    温小恒; 徐腾达; 盖小荣; 孙杰; 莎仁高娃

    2014-01-01

    Objective To investigate the relationship between carotid artery atherosclerosis and risk factor in a young and middle-aged population in China who received health checkup.Methods A total of 762 cases of young and middle-aged adult were recruited between April and October in 2013.These subjects had no hypertension,diabetes,coronary heart disease,cerebrovascular disease,and connective tissue disease,etc.Their Blood pressure,serum glucose (Glu),total cholesterol (TC),triglyceride (TG),and low density lipoprotein cholesterol (LDL-C) were measured and carotid artery ultrasonography was performed.Of the 762 cases,589 were male,173 were female,mean age was (46 ± 9) years.For blood pressure,blood lipids,the t test was performed to detect the difference between arteriosclerosis group and non arteriosclerosis group in different age groups.Logistic regression was performed to reveal the risk factors with carotid arteriosclerosis.Results Of the 762 subjects,205 had carotid artery atherosclerosis; 30.2% (178/589) of them were men and 15.6%(27/173) of them were women,with a significant difference between two groups,(x2=14.522,P=0.000).In the younger than 40 years old group,the diastolic blood pressure has statistical significance between carotid arteriosclerosis and non carotid arteriosclerosis group (t=-2.789,P< 0.05); blood sugar had statistically significant difference between the two groups (t value was-2.256,-2.930,-2.174,respectivly,P<0.05).Multiple regression analysis revealed that the independent risk factors for carotid artery arteriosclerosis were age,sex,DBP,and Glu.The regression coefficients were 0.993,0.711,0.047,0.334 seperately.The ROC curve of age was analyzed,the area under the ROC curve was 0.731,cut-off was 51 years old.Conclusions Routine carotid artery ultrasound should be performed for older than 50 healthy middle-aged men,to determine whether arteriosclerosis exists,especially for people with abnormal blood glucose or elevated DBP.%目的 分

  9. 盐酸沙格雷酯治疗下肢动脉硬化闭塞症的疗效观察%Effect of sarpogrelate hydrochloride for patients with atherosclerotic obliterans of legs

    Institute of Scientific and Technical Information of China (English)

    任师颜; 王非; 钱松屹; 樊雪强; 刘鹏

    2012-01-01

    Objecive:To evaluate the effect of sarpogrelate hydrochloride (anplag)for patients with atherosclerotic obliterans (ASO)of legs .Methods; The patients with ASO of legs were divided into sarpogrelate hydrochloride group (n=46)and control group (n =42).The patients in sarpogrelate hydrochloride group received sarpogrelate hydrochloride(100mg,tid)and aspirin(100mg.qd).whereas the patients in control group were administered aspirin (100mg,qd)only.The average therapeutic course was 130 days.Clinical manifestation,Rutherford type and ankle brachial index (ABl)were studied.Results:In comparison with control group,the severity of pain,Rutherford type 0 and 1 were improved with statistic significance(P<0.05,P<0.01).Incidence of patients with claudi-cation decreased from 56.6% before treatment to 28.3% after treatment; claudication distance was prolonged(P< 0.01);ABI were improved(0.74±0.17vs0.86±0.18,P<0.01).Conclusion:Anplag has therapeutic effect for patients with ASO of legs.%目的:研究盐酸沙格雷酯对下肢动脉硬化闭塞症(ASO)患者的疗效.方法:ASO患者分为盐酸沙格雷酯治疗组(n=46)和对照组(n=42).治疗组口服盐酸沙格雷酯、阿司匹林,对照组仅口服阿司匹林.每例患者口服阿司匹林100mg/d,盐酸沙格雷酯100mg,3次/d,服用130d.观察患者的临床表现、Rutherford 分型、踝肱指数(ABI)和药物不良反应.结果:治疗组患者感觉疼痛改善,步行距离增加,Rutherford 分型0级和1级患者的改善具有显著性差异(P<0.05,P<0.01).治疗后间歇性跛行从56.6%降低为28.3%,跛行距离显著延长(116.3±72.3m vs 243.5±175.3m,P<0.01),ABI指数显著改善(0.74±0.17 vs 0.86±0.18,P<0.01).结论:盐酸沙格雷酯对ASO患者有明显的治疗作用.

  10. Comparison of pulmonary function between bronchial asthma and bronchiolitis obliterans in infants%婴幼儿支气管哮喘和闭塞性细支气管炎患儿肺功能比较

    Institute of Scientific and Technical Information of China (English)

    向莉; 饶小春; 焦安夏; 李珍; 任亦欣

    2012-01-01

    Objective To compare the results of pulmonary function test between bronchia asthma and bronchio-litis obliterans (BO) in infants. Methods Fifty-seven infants with bronchial asthma and 47 infants with BO aged from 0 to 3 years old were selected. Their tidal breathing flow-volume curves were tested by Master Screen Paed and the parameters were recorded including respiratory rate (RR), tidal volume over body weight (VT/kg) , ratio of inspiratory time to expiratory time (TI/TE) , ratio of time to reach tidal peak flow to total expiratory time (TPTEF/TE) , ratio of volume at tidal peak flow to total tidal volume (VPEF/VE). Pulmonary compliance (CrsSO/kg) and airway resistance (Rrs) were examined by the single occlusion technique. Results There was no significant difference in VT/kg between asthma group and BO (P < 0.05). RR and Rrs of BO group were significantly higher than that of asthma group (P < 0.05) . The levels of TI/TE, TPTEF/TE, VPEF/VE, TEF50/TIF50 and CrsSOAg in BO group were significantly lower than those in asthma group respectively (P < 0.05). Conclusions In infants with BO, compare with infants with asthma, the resistance of respiratory system and the degree of small airway obstruction increase, but the respiratory system compliance decreases. The evaluation of lung function can provide certain help to differentiate BO and asthma in infants.%目的 比较婴幼儿支气管哮喘和闭塞性毛细支气管炎(BO)患儿肺功能差异.方法 选择57例婴幼儿支气管哮喘和47例BO患儿,应用Master Screen Paed型肺功能仪测定潮气呼吸流量容积曲线,分析参数包括呼吸频率(RR)、每千克体质量潮气量(VT/kg)、吸呼比(TI/TE)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、呼吸气中期流速比值(TEF50/TIF50).单阻断法测定每千克体质量呼吸系统顺应性(CrsSO/kg)和呼吸系统阻力(Rrs).结果 支气管哮喘和BO患儿VT/kg差异无统计学意义(P > 0.05);BO患儿RR、Rrs显著高于支气管

  11. Test de marcha de seis minutos en niños con bronquiolitis obliterante postviral: Correlación con espirometría Six minute walk test in children with post-infectious obliterans bronchiolitis: Its relation with spirometry

    Directory of Open Access Journals (Sweden)

    DANIEL ZENTENO A

    2008-03-01

    Full Text Available la Bronquiolitis Obliterante (BO postviral produce alteraciones en la función pulmonar que pueden repercutir en la capacidad para realizar ejercicio, la cual se puede evaluar con el test de marcha de 6 minutos (TM6. Objetivo: Estudiar con esta prueba a niños con BO postviral y determinar la relación entre variables espirométricas y los resultados del TM6. Veintisiete pacientes, se estudiaron con espirometría basal y TM6. Se relacionaron variables espirométricas con resultados del TM6: distancia caminada, índice de Borg (IB, saturación de oxígeno (Sa0(2 y frecuencia cardíaca (FC, mediante Rho de Spearman utilizando SPSS 11,5. No hubo correlación entre la distancia caminada y ninguna variable espirométrica; la CVF sólo se correlacionó con Sa0(2 final (rho = 0,4; p = 0,02. El resto de las variables espirométricas se correlacionaron con IB, Sa0(2 y FC; destacando VEF1 con: IB (rho = -0,7; p Post infectious obliterans bronchiolitis (OB causes persistent pulmonary function impairment and could affect patient ability to perform exercise. Six minute-walk test (6MWT is a useful tool to study these aspects. Objective: Children with OB were evaluated with spirometry and 6MWT and the relationship between spirometrics measurements and 6MWT were determined. Twenty-seven children with OB were studied with a base line spirometry and 6MWT. Correlation between spirometry and 6MWT: covered distance, Borg index (BI, oxygen saturation (0(2S and heart rate (HR, were carried out using Rho of Spearman with SPSS 11.5. There was not relation between the covered distance and spirometrics values; only FVC correlates with final 0(2S (rho = 0.4; p = 0.02. The other spirometrics variables correlates with BI, 0(2S andHR; Interestingly FEV1correlates with: BI (rho = -0.7; p < 0.01, 0(2S (rho = 0.5; p < 0.01 and HR (rho = -0.5; p < 0.01. BI was significant related to FEV1/FVC (rho = -0.7; p < 0.01 and FEF25-75 (rho = -0.8; p < 0.01. Airflow obstruction

  12. Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans

    Directory of Open Access Journals (Sweden)

    Rita Mattiello

    2010-08-01

    Full Text Available OBJETIVO: Descrever a função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa (BOPI e avaliar potenciais fatores de risco para pior função pulmonar. MÉTODOS: A função pulmonar de 77 participantes, com idades de 8-18 anos, foi avaliada por meio de espirometria e pletismografia. Os seguintes parâmetros foram analisados: CVF, VEF1, FEF25-75%, VEF1/CVF, VR, CPT, VR/CPT, volume de gás intratorácico e specific airway resistance (sRaw, resistência específica das vias aéreas. Foi utilizada a regressão de Poisson para investigar os seguintes potenciais fatores de risco para pior função pulmonar: sexo, idade do primeiro sibilo, idade ao diagnóstico, história familiar de asma, exposição ao tabaco, tempo de hospitalização e tempo de ventilação mecânica. RESULTADOS: A idade média foi de 13,5 anos. Houve uma diminuição importante de VEF1 e FEF25-75%, assim como um aumento de VR e sRaw, característicos de doença obstrutiva das vias aéreas. Os parâmetros mais afetados e as médias percentuais dos valores previstos foram VEF1 = 45,9%; FEF25-75% = 21,5%; VR = 281,1%; VR/CPT = 236,2%; e sRaw = 665,3%. Nenhum dos potenciais fatores de risco avaliados apresentou uma associação significativa com pior função pulmonar. CONCLUSÕES: As crianças com BOPI apresentaram um padrão comum de comprometimento grave da função pulmonar, caracterizado por uma obstrução importante das vias aéreas e um expressivo aumento de VR e sRaw. A combinação de medidas espirométricas e pletismográficas pode ser mais útil na avaliação do dano funcional, assim como no acompanhamento desses pacientes. Fatores de riscos conhecidos para doenças respiratórias não parecem estar associados a pior função pulmonar em BOPI.OBJECTIVE: To describe the pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans (PIBO, as well as to evaluate potential risk factors for severe impairment of

  13. Avaliação do estado nutricional de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Assessment of nutritional status in children and adolescents with post-infectious bronchiolitis obliterans

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Bosa

    2008-08-01

    bronchiolitis obliterans and to analyze associations with clinical and nutritional factors. METHODS: The study included 57 patients. Nutritional status was assessed using z scores for weight/age, stature/age, weight/stature in children, and stature/age and body mass index percentiles in adolescents. Body composition was assessed via tricipital skin folds, subscapular skin folds, and the sum of both plus the muscular circumference of the arm; pulmonary function was also investigated in subjects over 8 years old. RESULTS: The high percentages of malnutrition and risk for malnutrition are noteworthy: 21.7 and 17.5%, respectively. Among children, weight/age and stature/age detected higher percentages of malnutrition (21.6 and 16.2%, while weight/stature underestimated this diagnosis. Among adolescents, body mass index detected a high percentage of malnutrition (25% and of risk for malnutrition (20%. Body composition analysis detected 51% of patients with low muscle reserves, and the majority of patients had normal fat reserves. Compromised pulmonary function was associated with poor performance at exercise (r = 0.434; p = 0.024. Malnutrition and/or nutritional risk and low muscle reserves were significantly associated with the 6-minute walk test (p = 0.032; p = 0.030. There was no association between spirometry and the nutritional variables (p > 0.05. CONCLUSIONS: These results emphasize the need for nutritional intervention, and suggest that, in addition to using weight and height indices for nutritional assessment, it is necessary to combine these with an analysis of body composition, so that a larger number of patients with malnutrition and/or at an increased risk of developing malnutrition may be identified and correctly managed.

  14. Función pulmonar y calidad de vida en niños y adolescentes con bronquiolitis obliterante por adenovirus Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection

    Directory of Open Access Journals (Sweden)

    Stefhanie Nayar E

    2011-09-01

    Full Text Available Introducción: La infección por adenovirus es una causa importante de neumonía en niños chilenos. La bronquiolitis obliterante (BOPI es la complicación más importante. Existen pocos estudios donde evalúen la función pulmonar y la calidad de vida de los pacientes con BOPI. Objetivo: Evaluar la función pulmonar y la calidad de vida de los pacientes con BOPI y la correlación entre ambas variables. Métodos: Se incluyeron 14 niños con BOPI en elpoliclínico de la unidad de broncopulmonar de un hospital público de niños. Período de estudio: abril de 2009-abril de 2010. La función pulmonar se evaluó en una visita médica por espirometría, curva flujo / volumen y la determinación de volumen de gas intratorácico. Los índices analizados fueron los siguientes CVF, VEF1, FEV25-75, VEF1/CVF, VR,CPT, VR y VR / CPT. En la misma visita se realizó una encuesta auto-administrada de Calidad de Vida (PedsQL, versión 4.0, español de Chile para investigar la calidad de vida global, física y psi-cosocial. Se aplicó la correlación lineal de Pearson entre calidad de vida y los parámetros de función pulmonar. Se consideró estadísticamente significativo unp Introduction: Adenovirus infection is an important cause of pneumonia in Chilean children. Postinfectious Bronchiolitis Obliterans (PIBO is the most important complication. There are few studies assessing pulmonary function and quality of life in PIBO patients. Objective: The aim of this study is to assess the pulmonary function and the quality of life ofpatients with PIBO and the correlation between both variables. Methods: 14 children with PIBO in follow up at the pediatric pulmonology outpatient clinic of a public children hospital were included in this study. Study period: April 2009 - April 2010. Pulmonary function was assessed in a medical visit by spirometry, flow/volume curve and intrathoracic gas volume measurement. The following indices were analyzed FVC, FEV1, FEV25-75, FEV1/FVC

  15. Guía clínica para el diagnóstico y cuidado de niños/adolescentes con bronquiolitis obliterante post-infecciosa, 2009 Clinical guide for diagnosis and care of children and adolescents with post-infectious bronchiolitis obliterans, 2009

    Directory of Open Access Journals (Sweden)

    LUIS E VEGA-BRICEÑO

    2009-01-01

    Full Text Available La bronquiolitis obliterante (BO es un síndrome clínico poco frecuente en niños, caracterizado por la obstrucción crónica al flujo de aire asociado a cambios inflamatorios y distintos grados de fibrosis en la vía aérea pequeña. Si bien existen muchas etiologías, la causa más frecuente se asocia a infecciones respiratorias virales, principalmente adenovirus. No existe un consenso para establecer su diagnóstico; sin embargo, se considera un espectro de síntomas persistentes asociados a un patrón en mosaico, bronquiectasias y atelectasias persistentes. El papel de la biopsia pulmonar ha sido cuestionado por su bajo rendimiento, invasividad y complicaciones. No existe un tratamiento específico por lo que el manejo es soporte. Probablemente la mejor estrategia constituya el empleo de antibióticos en forma agresiva, soporte kinésico y nutricional constante y una precoz rehabilitación pulmonar. Estas guías clínicas representan un esfuerzo multidisciplinario, basado en evidencias actuales para brindar herramientas prácticas para el diagnóstico y cuidado de niños y adolescentes con BO post infecciosa.Bronchiolitis obliterans in children is an infrequent clinical syndrome, characterized by chronic airflow obstruction associated to inflammatory changes and different degrees of fibrosis in the small airways. Etiologies are varied but the most frequent one is the association with viral infections, mainly adenovirus. There is no consensus regarding diagnostic criteria, but a spectrum of persistent symptoms together with a mosaic pattern, bronchiectasis and persistent atelectasis is considered useful. Pulmonary biopsy has been questioned because of its low yield, invasiveness and complications. No specific treatment is available, therefore its treatment is supportive. Probably the best strategy is the aggressive use of antibiotics, constant kinesic and nutritional support and early pulmonary rehabilitation. This clinical guide represents

  16. The effect observation of rosuvastatin and simvastatin on elderly patients with lower limb arteriosclerosis disease%瑞舒伐他汀与辛伐他汀抗老年人下肢动脉硬化疾病效果观察

    Institute of Scientific and Technical Information of China (English)

    刘小芳

    2015-01-01

    Objective:To observe The effect of rosuvastatin and simvastatin on elderly patients with lower limb arteriosclerosis disease.Methods:65 cases of elderly patients with lower extremity arterial disease were divided into two groups.The experimental group selected rosuvastatin treatment,and the control group selected simvastatin treatment.Results:After treatment,the experimental group of TC,TG,HDL-C,LDL-C,hs-CRP were significant improved;after treatment,the lower extremity arterial intima-media thickness,arterial stenosis,plaque,hardening strength ratings are[1(1,1)],and the differences were statistically significant with the control group(P<0.05).Conclusion:Rosuvastatin and simvastatin play a role in the treatment of elderly patients with lower limb arteriosclerosis disease,but rosuvastatin effect is ideal.Its lipid levels and endometrial thickness,arterial stenosis,plaque,hardening intensity scores improve significantly.%目的:观察瑞舒伐他汀与辛伐他汀治疗老年人下肢动脉硬化疾病的临床效果。方法:收治老年人下肢动脉硬化疾病患者65例,分两组,试验组选择瑞舒伐他汀治疗,对照组选择辛伐他汀治疗。结果:试验组治疗后 TC、TG、HDL-C、LDL-C、hs-CRP均出现明显的改善趋势,其治疗后下肢动脉内膜厚度、动脉狭窄、斑块、硬化强度评分均为[1(1,1)],与对照组治疗后比较差异有统计学意义(P<0.05)。结论:瑞舒伐他汀与辛伐他汀在老年人下肢动脉硬化疾病治疗中均能发挥一定的作用,但瑞舒伐他汀效果较为理想,其血脂水平与下肢动脉内膜厚度、动脉狭窄、斑块、硬化强度评分改善明显。

  17. Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved? Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: um mistério a ser resolvido?

    Directory of Open Access Journals (Sweden)

    Edvaldo Luiz Ramalli Jr

    2011-09-01

    Full Text Available Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridgesDiversos estudos demonstram que as porções intramiocárdicas das artérias coronárias são poupadas da arteriosclerose, envolvendo aspectos morfológicos, embriológicos, biomecânicos e aspectos fisiopatológicos. A função endotelial é significativamente afetada no segmento de transição, tal como estimado pela resposta vasoativa para acetilcolina (Ach. Esses achados sugerem que ponte miocárdica pode fornecer proteção contra a arteriosclerose, por contrariar os efeitos negativos da disfunção endotelial. O fenômeno dessa proteção da porção intramiocárdica merece maior investigação científica em todas as frentes de pesquisa. Maiores conhecimentos sobre os aspectos morfológicos, biomecânicos e, principalmente, fisiológicos e embriológicos podem ser a chave para uma futura janela de oportunidades de terapia e prevenção da doença arterial crônica. Nessa revisão, discutem-se, também, possíveis abordagens terapêuticas para fenômenos coronarianos isquêmicos causados por pontes miocárdicas

  18. Subintimal angioplasty true lumen re-entry technology in the treatment of lower limb atherosclerosis obliterans%下肢动脉硬化闭塞症内膜下成形术中再入真腔技术的进展

    Institute of Scientific and Technical Information of China (English)

    周承校; 胡何节

    2012-01-01

    内膜下成形术近年来广泛应用于下肢动脉硬化闭塞症的介入治疗中,再入真腔技术是内膜下成形术的关键.本文综述了超声、同期双向内膜下血管成形术、导管系统等新兴技术在内膜下成形术中再入真腔技术的应用及各类技术的优缺点.%Subintimal angioplasty had been widely used in the intervention of lower extremity arterial obliterans disease in recent years.True lumen re-entry is the key to subintimal angioplasty.This comprehensive exposition of the true lumen re-entry can improve the chances of ultrasound and subintimal arterial flossing with antegraderetrograde intervention and catheter systems and other emerging technologies in the application of subintimal angioplasty,and various types of technology advantages and disadvantages.

  19. The effectiveness of endovascular revascularization for atherosclerosis obliterans in lower extremity:a 2-year experience%下肢动脉硬化闭塞症腔内治疗的疗效分析及2年内的随访观察

    Institute of Scientific and Technical Information of China (English)

    殷晓丽; 畅智慧; 王秋实; 刘兆玉

    2013-01-01

    Objective: To determine the efficacy, safety, and 2—year outcome, including patency and limb salvage, of en-dovascular revascularization in patients with lower extremity atherosclerosis obliterans. Methods: From July 2006 to June 2011, 274 limbs in 222 patients with lower extremity atherosclerosis obliterans were treated by endovascular revascularization. There were 162 males and 60 females, with the mean age of 67.5±11.2 years old. Ninty-two limbs in the aorta-iliac group, 101 limbs in the infrainguinal group, 31 limbs in the infra-popliteal group, and 50 limbs in multiple segment group. The most common presenting symptom was severe intermittent claudication(Rutherford 3, n=116), followed by rest pain (Rutherford 4, n= 87), non -healing ulcer (Rutherford 5, n=37) and gangrene (Rutherford 6, n=34). Patency was evaluated by using ultrasound scanning, CTA or DSA if necessary, and follow-up status was evaluated with the Kaplan-Meier method. Results: Immediate procedural and clinical success were achieved in 269 and 265 limbs respectively. Eighty-six limbs underwent angioplasty, while the rest 183 limbs underwent angioplasty plus stent placement. There were four perioperative death, and two major amputations within the first 30 days. Mean follow-up was 20.8±4.7 months (range, 9-75 months). Two hundred and thirty-five limbs had effective follow-up. Primary patenty rate, secondary patenty and limb salvage rate at 2 years were 71.5%, 75.7%, and 96.2%, respectively. Conclusion: Endovascular revascularization is a feasible, safe, and effective procedure for the treatment of lower extremity atherosclerosis obliterans.%目的:探讨腔内治疗的疗效及2年内的随访结果.方法:回顾性分析我院2006年7月-2011年6月的222例下肢动脉硬化闭塞症患者的资料,共274条患肢.本组病例中男162例,女60例,平均年龄(67.5±11.2)岁.根据不同的病变部位分为:主髂动脉病变92条肢体,股腘动脉101条肢体,膝下动脉31

  20. Bronquiolite obliterante: perfil clínico e radiológico de crianças acompanhadas em ambulatório de referência Bronquiolitis obliterante: perfil clínico y radiológico de 35 niños acompañados en ambulatorio de referencia Bronchiolitis obliterans: clinical and radiological profile of children followed-up in a reference outpatient clinic

    Directory of Open Access Journals (Sweden)

    Carolina Arcanjo Lino

    2013-03-01

    los pediatras frente a lactantes silbadores graves y perennes.OBJECTIVES: To describe the clinical and radiological characteristics of patients with bronchiolitis obliterans. METHODS: This is a retrospective and descriptive study. Data were collected from patients diagnosed with bronchiolitis obliterans between 2004 and 2008 in the Pediatric Pulmonology Clinic of Hospital Infantil Albert Sabin, in Ceará, Northeast Brazil. Such diagnosis was based on clinical and tomographic criteria. Previous history, clinical findings at the diagnosis, complementary exams, and follow-up data were evaluated. RESULTS: 35 children diagnosed with bronchiolitis obliterans were identified. There was a predominance of male patients (3:1. The mean age at the onset of symptoms was 7.5 months, and bronchiolitis obliterans was diagnosed at a mean age of 21.8 months. The most common clinical findings were crackles/wheezing, tachypnea, dyspnea, and chest deformity. Post-infectious etiology was the main cause of bronchiolitis obliterans. Predominant findings at chest X-ray and high resolution computed tomography were peri-bronchial thickening and mosaic pattern, respectively. The treatment was variable and individualized. The majority of patients improved during follow-up, despite the persistence of respiratory symptoms. CONCLUSIONS: In this study, the predominance of male patients and post-infectious etiology was noted, corroborating scientific literature. The most common tomographic findings were similar to those described in previous studies (mosaic pattern, peri-bronchial thickening, and bronchiectasis. Evidence about the treatment of this disease is still lacking. The diagnosis was delayed, which indicates that clinical suspicion of bronchiolitis obliterans is necessary in children with persistent and severe wheezing.

  1. An Approach to Relativity of the Lower Extremity Atherosclerosis Obliterans Syndrome Differentiation Typing and Endothelial Function%下肢动脉硬化闭塞症辨证分型与血管内皮功能相关性探讨

    Institute of Scientific and Technical Information of China (English)

    李建鹏; 王峥

    2011-01-01

    Objective:To research the relativity of the lower extremity atherosclerosis obliterans (ASO) syndrome differentiation typing and endothelial function.Methods: 161 cases of ASO in various typings based on syndrome differentiation were observed, the endothelial function indexes were detected.SPSS11.5 for windows software was adopted for statistical treatment.Results :ASO patients had severe endothelial dysfunction(ED) ,ET- 1 and TXB2 in blood plasma of Damp -heat pouring down syndrome group were significantly higher than other groups' s( P < 0.01 ), and the same result to Blood stasis syndrome group' s.But NO in blood serum and 6 - Keto - PGF1α in blood plasma of Damp - heat pouring down syndrome group and Blood stasis syndrome group were significantly lower than Yin -cold congealing syndrome group and Spleen- kidney yang deficiency syndrome group's(P < 0.05 )Conclusion: With respect to the severity of ED, Damp - heat pouring down syndrome group is highest, Blood stasis syndrome group take second place, Yin -cold congealing syndrome group and Spleen -kidney yang deficiency syndrome group is lower.%目的:探讨不同证型的下肢动脉硬化闭塞症(ASO)与血管内皮功能的相关性.方法:选择ASO患者共161例,经辨证后检测各证型患者血管内皮功能指标,采用SPSS 11.5软件包对数据进行统计学处理.结果:ASO患者存在较为严重的血管内皮功能障碍(ED),湿热下注证组患者血浆ET-1、TXB2水平高于其它证型组(P<0.01),血脉瘀阻证为其次;而血清NO水平在此两证型中低于阴寒结聚证及脾肾阳虚证(P<0.05).结论:下肢动脉硬化闭塞症(ASO)湿热下注证血管内皮功能障碍(ED)最为严重,其次为血脉瘀阻证,阴寒结聚证及脾肾阳虚证内皮功能障碍相对较轻.

  2. 载脂蛋白E基因多态性与中国人阿尔茨海默病 和颈动脉粥样硬化相关性研究%Association between ApoE gene polymorphism and Alzheimer’s disease and Carotic arteriosclerosis in Chinese

    Institute of Scientific and Technical Information of China (English)

    杨静芳; 陈彪; 柏华; 董秀敏; 武剑; 陈保生; 贾建平

    2001-01-01

    To investigate the relationship between apoE gene polymorphism and sporadic Alzheimers disease(SAD) and Carotic arteriosclerosis (CAS). ApoE gene distribution was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 46 SAD, 31 CAS and 50 normal controls. The ApoE 4 allele frequency was increased in both SAD and CAS as compared to controls. While the ApoE 2 allele frequency was much higher in CAS as compared to SAD. The ApoE 4 allele of ApoE gene may be risk factors for both SAD and CAS in Chinese, while the ApoE 2 allele genes may protect CAS individuals from SAD.%为了探讨中国散发性阿尔茨海默病(SAD)及颈动脉粥样硬化(CAS)与ApoE基因多态性的关系,应用聚合酶链式反应——限制性片段长度多态性(PCR-RFLP)技术检测46名SAD患者、31名CAS患者及50名正常老年人的ApoE基因多态性分布特征。结果显示SAD组及CAS组ApoE ε4等位基因频率均高于对照组(P<0.05):SAD组为15.2%, CAS组为14.5%, 对照组为3.0%;但CAS组ApoE ε2等位基因频率明显高于SAD组(P<0.05):CAS组为41.9%, SAD组为21.7%。本研究提示ApoE4等位基因是SAD和CAS的共同危险因素,但ApoE2等位基因对CAS病人患AD具有保护作用。

  3. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.

    Science.gov (United States)

    Cheng, Bo; Anea, Ciprian B; Yao, Lin; Chen, Feng; Patel, Vijay; Merloiu, Ana; Pati, Paramita; Caldwell, R William; Fulton, David J; Rudic, R Daniel

    2011-10-11

    The suprachiasmatic nucleus of the brain is the circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues to control circadian physiology. As such, central clock dysfunction can alter systemic homeostasis to consequently impair peripheral physiology in a manner that is secondary to circadian malfunction. To determine the impact of circadian clock function in organ transplantation and dissect the influence of intrinsic tissue clocks versus extrinsic clocks, we implemented a blood vessel grafting approach to surgically assemble a chimeric mouse that was part wild-type (WT) and part circadian clock mutant. Arterial isografts from donor WT mice that had been anastamosed to common carotid arteries of recipient WT mice (WT:WT) exhibited no pathology in this syngeneic transplant strategy. Similarly, when WT grafts were anastamosed to mice with disrupted circadian clocks, the structural features of the WT grafts immersed in the milieu of circadian malfunction were normal and absent of lesions, comparable to WT:WT grafts. In contrast, aortic grafts from Bmal1 knockout (KO) or Period-2,3 double-KO mice transplanted into littermate control WT mice developed robust arteriosclerotic disease. These lesions observed in donor grafts of Bmal1-KO were associated with up-regulation in T-cell receptors, macrophages, and infiltrating cells in the vascular grafts, but were independent of hemodynamics and B and T cell-mediated immunity. These data demonstrate the significance of intrinsic tissue clocks as an autonomous influence in experimental models of arteriosclerotic disease, which may have implications with regard to the influence of circadian clock function in organ transplantation.

  4. Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.

    Directory of Open Access Journals (Sweden)

    Hiroki Tanaka

    Full Text Available Abdominal aortic aneurysm (AAA is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.

  5. Study on the relationship of serum sP-selectin and hs-CRP with carotid arteriosclerosis in patients with acute ischemic stroke%急性缺血性卒中患者血清可溶性P-选择素、hs-CRP水平与颈动脉粥样硬化关系的研究

    Institute of Scientific and Technical Information of China (English)

    冯秋菊; 刘振伟; 万琦

    2014-01-01

    Objective It is tO investigate the assOciatiOn between levels Of serum sP -selectin,hs -CRP and extracranial carOtid arteriOsclerOsis in patients with acute ischemic strOke. Methods 120 inpatients with acute ischemic strOke attacking within 72 hOurs were selected and the serum sP-selectin,hs-CRP were measured by ELISA. A cOlOr DOppler ultrasOund sys-tem was used tO detect the plaque Of carOtid artery. Results The serum cOncentratiOns Of sP-selectin were different when the intima-media thickness Of ECCA,the nature Of plaque and the level Of carOtid artery stenOsis were different(P 0. 05). Conclusion The severer ex-tracranial carOtid atherOsclerOsis is the higher the serum cOncentratiOns Of sP -selectin are in acute ischemic strOke patients. There is a pOsitive relatiOnship between serum sP-selectin and carOtid atherOsclerOsis,and the activity is mOre sensitive than Hs-CRP in the detectiOn Of carOtid atherOsclerOsis.%目的:研究急性缺血性卒中患者血清可溶性 P-选择素( sP-selectin)、高敏 C反应蛋白( hs-CRP)水平与颈动脉粥样硬化程度的关系。方法选择发病72 h 内急性脑梗死患者120例,采用ELISA法测定患者血清sP-selectin及hs-CRP浓度,并应用颈动脉超声对斑块特点进行分析。结果不同颈总动脉内-中膜厚度、不同颈动脉斑块性质、不同颈动脉狭窄程度时,sP-selectin水平存在显著性差异( P<0.05);随着颈总动脉内-中膜厚度越厚,颈动脉斑块稳定性越差,颈动脉狭窄程度越重,sP -selectin 水平越高,而 hs -CRP 差异不显著。结论急性缺血性卒中患者sP-selectin水平随着颅外段颈动脉粥样硬化程度加重而升高,sP-selectin与动脉粥样硬化呈正相关;且较 hs-CRP更好地反映了颈动脉粥样硬化的程度。

  6. /sup 99m/Tc radionuclide angioscintigraphic perfusion analysis in the assessment and follow-up of peripheral vascular diseases of the lower limbs

    International Nuclear Information System (INIS)

    Peripheral arterial diseases (PADs) of the lower limbs such as thromboangitis obliterans (TAO) (Buerger's disease), arteriosclerosis obliterans (ASO) and diabetes mellitus, produce trophic disturbances occurring most often in the toes. Perfusion analysis of the foot and toes was previously reported. The analysis utilized radionuclide arteriography (RNA) during reactive hyperaemia to obtain peak activity in RNA time-activity curves (TACs). RNA was also used to assess healing capability of skin ulcers of the calf and ankle, which depends on localized enhancement of capillary blood flow. On these bases, detection of capillary blood flow assumes primary importance in the assessment of peripheral vascular disease (PVD). The purpose of this study was to determine whether RNA of the toes at rest could provide adequate assessment of microcirculation in PVD and of microcirculatory changes induced by lumbar sympathectomy (LS)

  7. Bronchiolitis obliterans organizing pneumonia during low-dose amiodarone therapy

    NARCIS (Netherlands)

    Jessurun, GAJ; Hoogenberg, K; Crijns, HJGM

    1997-01-01

    Two cases of amiodarone-induced pulmonary toxicity during a relatively short period of low-dose amiodarone treatment are reported. The toxicity risk of amiodarone is determined by cumulative factors in individual patients.

  8. Hybrid surgical treatment of lower extremity arterial occlusive disease and 26 cases of thrombosis Experience%杂交手术治疗下肢动脉硬化闭塞症并血栓形成26例体会

    Institute of Scientific and Technical Information of China (English)

    赵松峰; 李文明; 李彦州

    2013-01-01

    目的:探讨杂交手术对下肢动脉硬化闭塞症并血栓形成的疗效。方法回顾我科2005年-2010年26例下肢动脉硬化闭塞症并血栓形成患者行杂交手术治疗,全部股动脉切开取栓,其中球囊扩张者11例,支架置入者15例。结果26例患者术后肢体麻木症状减轻,发凉、疼痛症状缓解,跛行消失或跛行距离延长,ABI平均提高至0.98±0.13;出院后随访2-7年,其中死亡6例,糖尿病膝下动脉硬化闭塞1例,支架内动脉内膜增生血管狭窄2例。结论杂交手术是治疗下肢动脉硬化闭塞症并血栓形成的有效方法,严格把握手术适应症和合理选择手术方式是治疗的关键。%Objective To investigate the hybrid operation for arteriosclerosis obliterans and thrombosis treatment. Methods Retrospective our department in 2005-2010 26 cases of arteriosclerosis obliterans and thrombosis underwent surgical treatment of hybrids and all femoral artery incision embolectomy, in which 11 cases of balloon dilation, stent placement in 15 cases. Results Symptoms such as numbness, coldeness, pain, limp of the 26 patients have been relieved after operation, ABI has been increased to 0.98±0.13. The patients were followed up 2-7 years, 6 of them dead, 1 of them arteriosclerosis obliterans, 2 of them in-stent stenosis. Conclusion Surgery is the treatment of hybrid arteriosclerosis obliterans and effective way of thrombosis. Strictly control surgical indications and rational choice of surgical approach is the key to treatment.

  9. Osteonecrosis of Femoral Head Occurred after Stent Placement of Femoral Artery

    Directory of Open Access Journals (Sweden)

    Akiyoshi Shimatani

    2014-01-01

    Full Text Available We present a case of osteonecrosis of femoral head (ONFH that occurred after stent angiography of femoral artery for the treatment of arteriosclerosis obliterans (ASO of left inferior limb in a 76-year-old woman. No case of late collapse of femoral head as a complication of endovascular procedure such as stent placement has been previously documented. We considered that ONFH occurred after detaining stent at a junction of left deep femoral artery for the treatment of the ischemia of left lateral and medial femoral circumflex artery.

  10. Laser Biostimulation Of Wound Healing In Arteriopatic Patients

    Science.gov (United States)

    Tallarida, G.; Baldoni, F.; Raimondi, G.; Massaro, M.; Peruzzi, G.; Bertolotti, M.; Ferrari, A.; Scudieri, F.

    1981-05-01

    Low-power laser irradiation has been employed in the attempt to accelerate the wound-healing of ischemic cutaneous ulcerations with threatening or manifest gangrene due to arteriosclerosis obliterans of the lower limbs. Irradiation was performed by using a low-power He-Ne gas laser of 6328 Å wavelength and was concentrated at the peripheral zone of the lesions. The preliminary results of the study indicate that laser stimulation might be new approach in the conservative menagement of the ischemic ulcers in patients with severe peripheral obstructive arteriopaties not suited for arterial reconstruction.

  11. 周围动脉硬化指标结合运动负荷试验预测冠状动脉狭窄程度的临床意义%Clinical significance of combined peripheral arteriosclerosis index and exercise load test in predictiing severity of coronary artery stenosis

    Institute of Scientific and Technical Information of China (English)

    张红; 李小鹰; 罗学胜; 陈穗; 张建; 陈琳; 孟艳玲; 何璐

    2012-01-01

    Objectives To study the clinical significance of peripheral arteriosclerosis index in predicting early occurrence and severity of coronary heart disease. Methods Fifty-six patients admitted to Department of Cardiology, Chinese PLA General Hospital, were enrolled in this study. Their ankle-brachial index( ABI) ,brachial ankle artery pulse wave velocity(baPWV) ,and haPWV were measured before and after exercise by treadmill test followed by coronary angiography and analyzed by chi-squre test. The patients were divided into non-disease group(n= 9), non-significant stenosis group(n= 12) ,single vessel lesion group(n=17) ,2-vessel lesion group and 3-vessel lesion group according to their angiographic findings. Results No significant difference was found in ABI among the 4 groups at rest(P>0. 05). The baPWV and haPWV were significantly higher in coronary heart disease group than in non-disease group(P0. 05). The ABI, baPWV and haPWV decreased immediately after treadmill exercise. Conclusion The significantly increased resting baPWV and haPWV can predict coronary heart disease,but cannot predict its severity. The ABI before and after exercise and the baPWV and haPWV after exercise can hardly predict the occurrence and severity of coronary heart disease.%目的 探讨周围动脉硬化指标对早期预测冠心病及冠状动脉病变程度的临床意义.方法 随机选取解放军总医院心内科住院患者56例,平板运动试验前后完成静息性及运动后即刻踝臂指数( ankle-brachial index,ABI);肱动脉-踝动脉脉搏波速度(brachial ankle artery pulse wave velocity,baPWV)、上行主动脉-踝动脉脉搏波速度(haPWV)检测,同时完成冠状动脉造影检查,根据造影结果,分为无病变组9例,无意义狭窄组12例,单支病变组17例,双支病变组9例及3支病变组9例,对各组患者运动前后ABI、baPWV及haPWV进行统计学分析.结果 静息状态下,与无病变组比较,冠状动脉病变各

  12. Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke Arteriosclerosis y nuevas perspectivas de los inhibidores del receptor GPIIb/IIIa en stroke

    Directory of Open Access Journals (Sweden)

    GUSTAVO SAPOSNIK

    2000-03-01

    Full Text Available Ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. Antiplatelets agents did show benefit in secondary prevention. Aspirin is the most common antiaggregant in clinical use today. However, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. The adherence of circulating platelets to the subendothelium is mediated by glycoprotein (GP residing on the cell's surface. GPIIb/IIIa is the most important platelet membrane receptor that mediates the process of platelet aggregation, and thrombus formation. Thus, new drugs that block the GPIIb/IIIa receptor have recently emerged. Clinical trials using these agents have shown effectiveness in acute coronary syndromes. However, the absence of studies in cerebrovascular disease and the potential hemorrhagic complications questioned their use in stroke prevention. We review the clinical trials using the new GPIIb/IIIa agents in myocardial ischemia, and consider the potential implications for cerebrovascular disease.Los mecanismos de isquemia en infarto de miocardio y enfermedad cerebrovascular (ECV han sido estudiados por mas de 150 años. Drogas antiplaquetarias mostraron un beneficio en la prevención secundaria. La aspirina es el mas común de los antiagregantes usados en la practica clínica. No obstante, el beneficio producido, aun con el "mejor" tratamiento antiagregante, en la prevención de ECV es inferior al 40%. La adhesión plaquetaria es un proceso mediado por glicoproteinas (GP de la membrana celular. GPIIb/IIIa es un receptor de membrana plaquetaria que interviene en el proceso de agregación plaquetaria y formación del trombo. Estudios clínicos con nuevos agentes que bloquean a este receptor mostraron ser efectivos en los síndromes coronarios agudos. No obstante, la falta de estudios en ECV y las potenciales complicaciones hemorrágicas, limitan su uso en la prevención de stroke. Revisamos los mecanismos de trombogenésis y los estudios clínicos con los nuevos agentes GPIIb/IIIa, considerando sus implicancias en ECV.

  13. Relationship between non-dipper hypertension and arteriosclerosis in the elderly

    Institute of Scientific and Technical Information of China (English)

    陈策

    2014-01-01

    Objective To investigate the influence of non-dipper blood pressure rhythm on peripheral atherosclerosis in elderly hypertensive patients.Methods The 199 elderly hypertensive patients with 24-hour average systolic blood pressure<140 mmH g were selected.Body mass index(BMI),glycosylated hemoglobin,blood lipids,uric acid,creatinine,Brachial ankle pulse wave velocity(ba PWV),ankle arm index(ABI)and 24-hour ambulatory blood pressure monitoring were tested and calculated.The elderly patients were divided into dipper hypertensive group(n=95),and non-dipper hypertensive

  14. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    Energy Technology Data Exchange (ETDEWEB)

    Campo, Adriaan; Dirckx, Joris [University of Antwerp, Laboratory of Biomedical Physics, Groenenborgerlaan 171 2020 Antwerp (Belgium)

    2014-05-27

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  15. Intrathymic immune modulation prevents acute rejection but not the development of graft arteriosclerosis (chronic rejection)

    NARCIS (Netherlands)

    Hillebrands, JL; Raue, HP; Klatter, FA; Hylkema, MN; Platteel, [No Value; Hardonk-Wubbena, A; Nieuwenhuis, P; Rozing, J

    2001-01-01

    Background. We showed previously that our intrathymic immune modulation protocol induces virtually permanent graft survival of simultaneously transplanted cardiac allografts in MHC-incompatible rat strain combinations. It is, however, unknown whether this procedure prevents the development of graft

  16. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    Science.gov (United States)

    Campo, Adriaan; Dirckx, Joris

    2014-05-01

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  17. Minimal distal pressure rise after reconstructive arterial surgery in patients with multiple obstructive arteriosclerosis

    DEFF Research Database (Denmark)

    Noer, Ivan; Tønnesen, K H; Sager, P

    1980-01-01

    Forty-one reconstructive procedures were carried out in thirty-five consecutive patients. Average age was 63 years (range 46-75). Thrombendarterectomy or by-pass procedures were carried out in twenty-nine proximal and twelve femoropopliteal reconstructions. Twenty-three patients had rest pain fif...

  18. Impact of arteriosclerosis on the functioning of arteriovenous fistula for hemodialysis

    Directory of Open Access Journals (Sweden)

    Stolić Radojica

    2007-01-01

    Full Text Available Background/Aim. Numerous clinical studies have shown that the incidence of artheriosclerosis is higher in patients with progressive renal insufficiency. The aim of this study was to examine the incidence of artheriosclerosis in patients on chronic hemodialysis and its influence on survival and functioning of vascular access. Methods. The study was organized as one-year prospective study. All the patients had arteriovenous fistulas native as a vascular access. The study analyzed demographic, biochemical, clinical and Doppler echomorphological characteristics of the patients in order to make an evidence of artheriosclerotic incidences as compared to functioning arteriovenous fistulas for hemodialysis. Results. The examined patients were of the mean age 55.7±12.68 years. Of them, 53.8% were males and 46.2% females. Functioning arteriovenous fistulas for haemodialysis were found in 56.8% of the examined patients. Concentration of hemoglobin was a significant parameter of functioning fistula (group with complications - 89±14.034 vs. group with no complications - 96.6±17.71; p = 0.0489. An amount of urea removed (URR was a statistically more significant parameter among the patients without fistula complications: (group with complications - 58.67±7.92% vs. group with no complications - 62.80±7.53%; p = 0.037. A Cox regressive analysis of an index of Doppler parameters of the carotid arteries found no statistical significance between the examined groups. There was a positive correlation between artheriosclerosis and the age, as well as the time on dialysis. In multiple regression, where intima media is a dependent and the age and time on dialysis independent variables, the regressive model was statistically significant (F = 8.22, p = 0.001. Both independent variables had statistically significant inclinations, p < 0.01. Conclusion. Anemia and the level of urea elimination, as a statistically significant indicator of hemodialysis adequacy, were in correlation with the risk for fistula complications. B-mode ultrasonography of the carotid arteries is a significant non-invasive method for detecting artheriosclerosis. Intima- media thickness of the carotid arteries was an important marker of artheriosclerosis correlating significantly with the age and time on dialysis, but not with the traditional risk factors.

  19. Origin of vascular smooth muscle cells and the role of circulating stem cells in transplant arteriosclerosis

    NARCIS (Netherlands)

    Hillebrands, JL; Klatter, FA; Rozing, J

    2003-01-01

    To date, clinical solid-organ transplantation has not achieved its goals as a long-term treatment for patients with end-stage organ failure. Development of so-called chronic transplant dysfunction (CTD) is now recognized as the predominant cause of allograft loss long term (after the first postopera

  20. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    International Nuclear Information System (INIS)

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation

  1. The evaluation of asymptomatic arterial occlusive disease of the legs using an exercise test.

    Directory of Open Access Journals (Sweden)

    Usui,Yoshiyuki

    1984-12-01

    Full Text Available The Doppler-derived ankle pressure index (API is a useful indicator of the necessity for peripheral vascular reconstruction of the lower extremities. But the API at rest dose not reflect the functional capacity of leg circulation, especially in the early stage of disease. Therefore, an asymptomatic but hemodynamically significant lesion in one leg is sometimes missed by pressure measurement at rest when there is a severe lesion with symptoms in the other leg. In this study, the API not only at rest but also after exercise was measured in twenty normal subjects and thirty-two patients with angiographically proven arteriosclerosis obliterans. About 60% of the patients had unilateral symptoms, although they had significant disease bilaterally. The API after exercise proved to be more sensitive than the API at rest and may be useful in assessing asymptomatic legs of such patients and determining their surgical indication.

  2. Treatment of lower extremity arterial occlusive through retrograde access

    International Nuclear Information System (INIS)

    Objective: To explore the clinical significance of retrograde access for the interventional treatment of lower extremity arterial occlusive diseases when the occluded segment of lower extremity artery could not be reached through antegrade access. Methods: Twenty-seven cases (male 17, female 10; age range 32-89 years) were retrospectively investigated, including 18 with lower limb arteriosclerosis obliterans, 7 with diabetic foot and 2 with thromboangiitis obliterans. According to the Fontaine staging, 6 cases were classified as Fontaine Ⅱ, 11 were classified as Fontaine Ⅲ and 10 were classified as Fontaine Ⅳ. All cases underwent endovascular operation through antegrade access first with an attempt to cross the occlusive segment, but in vain. So retrograde access was tried via puncture of pedis dorsalis or posterior tibial artery or exposure of lateral branches of posterior tibial artery, peroneal artery or dorsal artery by open surgery,which followed by Percutaneous transluminal angiography and (or) stenting. Results: The operation through retrograde access was successful in all cases with obvious improvement of ischemic symptoms. Hematoma at the puncture site occurred in 3 patients, and paresthesia of toes occurred in 1 after dorsalis pedis arteriotomy. No severe perioperative complication occurred. The average ankle brachial index increased from 0.37 ± 0.11 preoperatively to 0.85 ± 0.12 postoperatively. Conclusions: Retrograde access could be used as an alternative strategy in lower extremity arterial occlusive diseases when the occluded segment could not reach through antegrade access. (authors)

  3. A case of bronchiolitis obliterans organizing pneumonia (BOOP) after breast conserving therapy for early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Shinya; Kiryuu, Takuji; Maeda, Sunao; Hoshi, Hiroaki; Shimokawa, Kuniyasu [Gifu Univ. (Japan). School of Medicine; Kawaguchi, Shimpei

    2001-03-01

    A case of BOOP occurring after radiotherapy for breast cancer was reported. TBLB and BAL were performed at the time of diagnosis. This case suggested that radiographic changes began in the irradiated area, then later spread to non-irradiated areas. In this article, we discussed the peculiary radiographic image, pathological manifestation, BAL characteristics and clinical course in this sequela. (author)

  4. 儿童闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    王维; 申昆玲

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是1901年德国病理学家Lange首次报道并命名的。从病理学角度,BO被定义为两种类型的支气管损伤:狭窄性细支气管炎和增殖性细支气管炎。从临床意义上讲,BO是一种与小气道炎症损伤相关的慢性气流阻塞综合征。各种因素导致的细支气管上皮细胞和上皮下结构的损伤和炎症,及机体对以上损伤和炎症的不正当修复是BO的发病原因。

  5. [A case of bronchiolitis obliterans organizing pneumonia: diagnostic utility of bronchoalveolar lavage and CT scan].

    Science.gov (United States)

    Hyakudo, T; Yoshii, C; Nikaido, Y; Yokosaki, Y; Nagata, N; Nakata, H; Kido, M

    1994-08-01

    A 54-year-old female was admitted to our hospital because of abnormal shadows on chest X-ray at annual checkup. She complained of dyspnea on exertion. Chest X-ray findings showed an increase in density at the bilateral lower lung fields and unclearness of the silhouette of the heart and the diaphragm. CT scan findings revealed irregular opacities of various density with many small cystic changes and air bronchograms and air bronchiolograms. The pulmonary function test showed restrictive ventilatory disturbance and reduced diffusing capacity. BALF findings revealed an increase in the total cell count, an increase in the percentage of lymphocytes and a decrease in the OKT4+/OKT8+ ratio. TBLB specimen showed infiltration of mononuclear cells in alveolar septa and organizing exudate in alveolar ducts. These findings suggested a diagnosis of BOOP rather than IPF, and an open lung biopsy was performed. Open lung biopsy specimen showed obstructive bronchiolitis with polypoid granulation tissue and thickening of alveolar septa with infiltration of mononuclear cells, and she was diagnosed as having BOOP. She responded well to corticosteroid and is free from any abnormalities on chest X-ray, CT scan and pulmonary function test at present. Analysis of BALF and CT scan findings are useful for the differential diagnosis of BOOP and IPF. PMID:7807756

  6. Direct measured systolic pressure gradients across the aorto-iliac segment in multiple-level-obstruction arteriosclerosis

    DEFF Research Database (Denmark)

    Noer, Ivan; Praestholm, J; Tønnesen, K H

    1981-01-01

    Patients with severe ischemia due to multi-level obstructions in the leg arteries both above and below the region were assessed preoperatively by intraarterial brachial and femoral artery pressure measurements. The systolic pressure drop along aorto-iliac obstructions was compared to the angiogra...

  7. Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

    OpenAIRE

    Flynn, Ryan; Du, Jing; Veenstra, Rachelle G.; Reichenbach, Dawn K.; Panoskaltsis-Mortari, Angela; Taylor, Patricia A.; Freeman, Gordon J.; Serody, Jonathan S.; Murphy, William J.; Munn, David H.; Sarantopoulos, Stefanie; Luznik, Leo; Maillard, Ivan; Koreth, John; Cutler, Corey

    2014-01-01

    T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model.Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.

  8. Evaluation of atherosclerotic change of the aorta by enhanced computed tomography

    International Nuclear Information System (INIS)

    Intimal atherosclerotic changes of the aorta were quantified by enhanced computed tomography (enhanced CT) and were examined in terms of their relation to other atherosclerotic characteristics, including calcification and aortic pulse wave velocity, diameter of the aorta, and arteriosclerotic risk factors. A total of 413 subjects were studied, consisting of normal volunteers and patients with cardiovascular diseases. Enhanced CT revealed the atheromatous intima as a projecting and thickened wall. Thus, the ratio of the intimal atherosclerotic change to the whole round was determined in various aortic sites. The diameter of the aorta decreased in accordance with the location from the ascending aorta to aortic ending. The diameter of the infrarenal abdominal aorta was 1.5 times larger than that of the ascending aorta, irrespective of age. The diameter of each region of the aorta increased with advancing age; in the age group of 70 years or older, it was 1.5 times larger that that in the age group of 40 years or younger. The intimal change was noted in the middle descending thoracic aorta and infrarenal abdominal aorta. It was proportional to an increase in the aortic pulse wave velocity, the diameter of the aorta, and the intimal calcification. Intimal changes of the aorta were increased in cerebrovascular disease, ischemic heart disease, arteriosclerosis obliterans, hypertension and diabetes mellitus. In particular, hypertension accompanied by diabetes mellitus or high cholesterolemia tended to accelerate the intimal change. In conclusion, aortic intimal changes, as detected on enhanced CT, is useful for the noninvasive diagnosis of arteriosclerosis. (N.K.)

  9. Evaluation of atherosclerotic change of the aorta by enhanced computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Takasu, Junichiro (Chiba Univ. (Japan). School of Medicine)

    1990-10-01

    Intimal atherosclerotic changes of the aorta were quantified by enhanced computed tomography (enhanced CT) and were examined in terms of their relation to other atherosclerotic characteristics, including calcification and aortic pulse wave velocity, diameter of the aorta, and arteriosclerotic risk factors. A total of 413 subjects were studied, consisting of normal volunteers and patients with cardiovascular diseases. Enhanced CT revealed the atheromatous intima as a projecting and thickened wall. Thus, the ratio of the intimal atherosclerotic change to the whole round was determined in various aortic sites. The diameter of the aorta decreased in accordance with the location from the ascending aorta to aortic ending. The diameter of the infrarenal abdominal aorta was 1.5 times larger than that of the ascending aorta, irrespective of age. The diameter of each region of the aorta increased with advancing age; in the age group of 70 years or older, it was 1.5 times larger that that in the age group of 40 years or younger. The intimal change was noted in the middle descending thoracic aorta and infrarenal abdominal aorta. It was proportional to an increase in the aortic pulse wave velocity, the diameter of the aorta, and the intimal calcification. Intimal changes of the aorta were increased in cerebrovascular disease, ischemic heart disease, arteriosclerosis obliterans, hypertension and diabetes mellitus. In particular, hypertension accompanied by diabetes mellitus or high cholesterolemia tended to accelerate the intimal change. In conclusion, aortic intimal changes, as detected on enhanced CT, is useful for the noninvasive diagnosis of arteriosclerosis. (N.K.).

  10. Primary appendiceal adenocarcinoma of colonic type with perforating peritonitis.

    Directory of Open Access Journals (Sweden)

    Noguch H

    2001-10-01

    Full Text Available Primary adenocarcinoma of the appendix is rare, especially the colonic type. We report a case of appendiceal adenocarcinoma of colonic type associated with perforating peritonitis after aorto-femoral artery bypass surgery. A 79-year-old woman presented with fever and pain in the right lower abdomen. She had undergone aorto-femoral artery bypass surgery due to arteriosclerosis obliterans 6 months earlier. Abdominal ultrasonography and computed tomography showed a suspected pool of fluid surrounding the artificial vessel and a mass lesion in the upper end of the fluid collection. These findings suggested localized peritonitis due to appendiceal perforation. Emergency laparotomy showed a pool of pus around the artificial vessel and inflamed appendix, which adhered to the surrounding tissue. The mass was excised in combination with an ileocaecal resection, followed by an ileocolic anastomosis. The histological diagnosis was moderately differentiated adenocarcinoma of the appendix, colonic type. The tumour had infiltrated and obstructed the lumen of the orifice of the appendix, which may have caused perforation of the appendix. She was examined at regular periodic follow-ups and no evidence of recurrence or metastasis was noted in the 12-month postoperative period. These findings indicate that, in cases of acute appendicitis, especially with perforation, the possibility of appendiceal adenocarcinoma should be considered.

  11. Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population.

    Directory of Open Access Journals (Sweden)

    Natsuhiko Kumasaka

    Full Text Available Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs and single nucleotide polymorphisms (SNPs associated with the number of cigarettes smoked per day (CPD in Japanese smokers (N = 17,158. Our analysis identified a common CNP with a strong effect on CPD (rs8102683; P=3.8 x 10(-42 in the 19q13 region, encompassing the CYP2A6 locus. After adjustment for the associated CNP, we found an additional associated SNP (rs11878604; P=9.7 x 10(-30 located 30 kb downstream of the CYP2A6 gene. Imputation of the CYP2A6 locus revealed that haplotypes underlying the CNP and the SNP corresponded to classical, functional alleles of CYP2A6 gene that regulate nicotine metabolism and explained 2% of the phenotypic variance of CPD (ANOVA F-test P=9.5 x 10(-52. These haplotypes were also associated with smoking-related diseases, including lung cancer, chronic obstructive pulmonary disease and arteriosclerosis obliterans.

  12. Cholesterol-Lowering Atherosclerosis Study (CLAS)

    Science.gov (United States)

    2013-12-12

    Arterial Occlusive Diseases; Cardiovascular Diseases; Carotid Artery Diseases; Cerebral Arteriosclerosis; Cerebrovascular Disorders; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Atherosclerosis

  13. Correlation between cardiac syndrome X and arteriosclerosis%X综合征与动脉硬化程度的相关性研究

    Institute of Scientific and Technical Information of China (English)

    李南; 严研; 韩静

    2013-01-01

    Objective To understand the effect of vascular endothelial function and athrosclerosis on cardiac syndrome X by studying the corralation between carotid intima media thickness (IMT),brachial artery flow-mediated dilatation (FMD) and cardiac syndrome X.Methods Sixtythree cardiac syndrome X patients served as cardiac syndrome X patients group and 40 healthy subjects served as a control group in this study.Their carotid IMT and brachial artery FMD,measured with a high-resolution 2D ultrasonic diagnostic appartus,were analyzed.Results The brachial artery FMD was significantly lower whereas the carotid IMT was significantly higher in cardiac syndrome X patients group than in control group (3.25% ±2.36% vs 5.99% ±3.63%,P<0.01;1.03±0.36 mm vs 0.79±0.09 mm,P<0.01).Linear correlation analysis showed that the brachial artery FMD was negatively correlated with the carotid IMT (r =-0.249,P =0.013).Univariate regression analysis displayed that the systolic blood pressure and smoking were the high risk factors for brachial artery FMD.Multivariate regression analysis revealed that the advanced age was an independent risk factor for the carotid IMT while the HDL-C was an independent protective factor for the carotid IMT.Conclusion The carotid IMT is significantly higher whereas the brachial artery FMD is significantly lower in cardiac syndrome X patients than in healthy subjects.The brachial artery FMD is negatively correlated with the carotid IMT.%目的 本研究通过运用无创检查方法对X综合征患者颈动脉内膜中层厚度(intima-media thickness,IMT)、肱动脉血流介导的血管扩张功能(flow mediated dilation,FMD)的检测,探讨颈动脉IMT、肱动脉FMD与X综合征的相关性,从而了解血管内皮功能和动脉硬化程度对X综合征的影响.方法 选择X综合征患者63例(X综合征组),另选健康体检者40例(对照组).应用高分辨率二维超声诊断仪分别检测2组的颈动脉IMT、肱动脉FMD,并进行比较分析.结果 X综合征组肱动脉FMD明显低于对照组[(3.25±2.36)% vs(5.99±3.63)%,P<0.01],颈动脉IMT明显大于对照组[(1.03±0.36)mm vs(0.79±0.09)mm,P<0.01].直线相关分析显示,FMD与IMT呈负相关(r=-0.249.P=0.013).单因素回归分析显示,收缩压和吸烟是肱动脉FMD的高风险因素.多因素回归分析显示,收缩压是肱动脉FMD的独立危险因素,年龄是颈动脉IMT的独立危险因素,HDL-C是颈动脉IMT的独立保护因素.结论 X综合征患者较健康体检者颈动脉IMT明显增厚,肱动脉FMD明显降低.肱动脉FMD与颈动脉IMT呈负相关.

  14. Alzheimer Disease and Arteriosclerosis Factors%阿尔茨海默病与血管因素的关系探讨

    Institute of Scientific and Technical Information of China (English)

    任刚; 陈祥慧; 刘文运; 李友莲

    2012-01-01

    目的 探讨阿尔茨海默病( Alzheimer disease AD) 与血管危险因素之间的关系.方法 选取临床诊断为AD 患者68例作为观察组,认知功能正常老年人70 例为对照组.两组性别、职业及受教育程度相匹配,分析两组中高血压、糖尿病、脂代谢紊乱、高同型半胱氨酸血症、颅内各血管血流速度减慢、颈部血管狭窄以及脑梗死的分布情况,以Logistic 回归模型分析各因素与AD 的关系.结果 高血压、糖尿病、血脂代谢异常、高同型半胱氨酸血症、颅内各血管血流速度减慢、颈部血管狭窄以及脑梗死在AD 与对照组之间差异有统计学意义( P < 0.05).结论 AD 与血管性因素有关,高血压、糖尿病、血脂代谢异常、脑梗死、颈部血管狭窄是AD 的独立危险因素.

  15. Ubiquitin-Proteasome Pathway and Arteriosclerosis%泛素蛋白酶体通路与动脉粥样硬化

    Institute of Scientific and Technical Information of China (English)

    王世超; 吕鑫; 吴江

    2015-01-01

    泛素-蛋白酶体通路(ubiquitin-proteasome pathway,UPP)是广泛存在于真核细胞中的,依赖ATP的选择性蛋白质降解的主要途径.泛素的主要功能是标记细胞中需要降解的蛋白质,使其被26S蛋白酶体识别和降解.UPP主要通过介导细胞中蛋白的降解而发挥调节作用.该通路的异常与许多疾病诸如肿瘤、遗传性疾病、神经退行性疾病、心血管疾病等密切相关.本文主要综述了UPP在动脉粥样硬化的发生,发展和复合病变中的作用.

  16. 骨质疏松与动脉硬化的研究现状%Current Research Status of Relationship between Osteoporosis and Arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    姚麒

    2011-01-01

    动脉硬化和骨质疏松是两种常见的老年病,两者具有相同的危险因素和病理生理机制.护骨素、基质Gla 蛋白、维生素D、甲状旁腺素、骨桥蛋白、氧化脂质等均参与或加速了两者的共同发病.基于两者相似的发病机制,使用他汀类药物、双磷酸盐、护骨素等药物可同时对骨量丢失和动脉硬化起保护作用,这是今后治疗动脉硬化和骨质疏松的一个新思路.%Atherosclerosis and osteoporosis are very common chronic diseases in elders.Both have the same risk factors and pathophysiological mechanisms, such as osteoprotegerin, matrix Gla protein, vitamin D, parathyroid gland, osteopontin, lipid oxidation, participate or accelerate these disease.Statins, biphosphonates,osteoprotegerin based on the biological linkage of the above entities may benefit both bone and vascular.And it’s expected to bring a new method of the prevention and treatment of osteoporosis and aerosclerosis.

  17. Types of Childhood Interstitial Lung Disease

    Science.gov (United States)

    ... or postinfectious disease ( bronchiolitis obliterans) Eosinophilic pneumonia Pulmonary alveolar proteinosis Pulmonary infiltrates with eosinophilia Pulmonary lymphatic disorders (lymphangiomatosis, ...

  18. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    OpenAIRE

    JUAN I. VARGAS RT.; SARA CHERNILO S.

    2003-01-01

    Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP), sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativ...

  19. Lipidómica, una herramienta para determinar nuevos biomarcadores de riesgo cardiovascular, obesidad y diabetes

    OpenAIRE

    Balsinde, Jesús

    2012-01-01

    Trabajo presentado al 25 Congreso Nacional de la Sociedad Española de Arteriosclerosis: Symposium satélite pre-congreso: "Diabetes y Arteriosclerosis", celebrado en Tarragona del 5 al 6 de junio de 2012.

  20. After Discharge Management of Low Income Frail Elderly

    Science.gov (United States)

    2014-07-16

    Heart Failure, Congestive; Coronary Arteriosclerosis; Atrial Fibrillation; Cerebrovascular Accident; Pulmonary Disease, Chronic Obstructive; Diabetes Mellitus; Hypertension; Osteoarthritis; Osteoporosis

  1. Prediction value of cardio-ankle vascular index in coronary arteriosclerosis%心脏脚踝指数对冠状动脉粥样硬化的预测价值

    Institute of Scientific and Technical Information of China (English)

    欧邦豪; 李博; 方胜先; 吴清华; 黄雪兰; 李家梅

    2016-01-01

    目的 讨论研究心脏脚踝指数(CAVI)、最大颈动脉内中膜厚度(Max IMT)及平均颈动脉内中膜厚度(MeanIMT)对冠状动脉粥样硬化的预测诊断价值.方法 选取我院心内科冠心病拟行冠状动脉造影(CAG)患者90例作为研究对象,根据CAG结果及Gensini评分,分为正常组A组(得分0分),B组(得分在1~80分)及C组(评分为81~160分),并以B、C组作为CAG阳性组.对三组人员分别进行空腹采血及CAVI、Max IMT及Mean IMT.结果 CAVI、Max IMT及Mean IMT三项指标中,CAVI曲线下面积显然大于其余两项指标;其次为Max IMT.说明CAVI预测动脉粥样硬化的价值显然高于其余两项指标.同时CAVI、Max IMT及Mean IMT对预测粥样硬化的CUT-OFF值、敏感性及特异性分别为8.84、84.01%及69.00%;1.33、74.51%及74.00%;0.92、68.85%及73.22%.CAVI、Max IMT及Mean IMT的三项评分均与Gensini评分呈正相关,评分分别为0.56(P<0.01)、0.32(P<0.05)、0.41(P<0.01),其中CAVI与该项评分相关性最强.CAVI假阳性率显著低于Max IMT及Mean IMT,CAVI阴性预测性显著高于其余两项指标,Mean IMT阴性预测值最小.结论 CAVI相对于Max IMT及Mean IMT两个指标对判断动脉粥样硬化更具有预测价值,且该指数变化随动脉粥样硬化程度加重而逐渐升高,对临床判断冠心病及相关疾病风险具有重要意义.

  2. [Effect of anti-arteriosclerosis diet, containing soya protein isolate and omega-3 polyunsaturated fatty acids on the activity of mononuclear and platelet lysosomal hydrolases in patients with hypertension and ischemic heart disease].

    Science.gov (United States)

    Samsonov, M A; Pogozhaeva, A V; Vasilév, A V; Bogdanova, S N; Pokrovskaia, G R; Varsanovich, E A; Orlova, L A

    1993-01-01

    In response to antiatherosclerosis dietotherapy containing 20 g of ichthyenic oil, coronary and hypertensive subjects showed lowered serum levels of cholesterol, triglycerides and atherogenic index, elevated HDLP cholesterol and corrected immunochemical shifts. SPI-containing diet resulted in changes of CIC IgM levels only. Shifts in the activity of mononuclear and platelet lysosomal hydrolases which occurred in the above patients due to relevant diets reflect higher sensitivity of this parameter in assessment of the dietotherapy effectiveness. PMID:7975402

  3. Observation of Curative Effect on Cerebral Arteriosclerosis Treated by Deng zhan Huasu Injection and Cerebrolysin%灯盏花素注射液合脑活素治疗脑动脉硬化症疗效观察

    Institute of Scientific and Technical Information of China (English)

    尹韶刚

    2004-01-01

    目的:观察灯盏花素注射液合脑活素治疗脑动脉硬化症的疗效.方法:将185例随机分为两组:对照组94例采用脑活素静脉注射,每天1次;治疗组91例,在上述治疗的基础上,加用灯盏花素注射液静脉注射,每天1次.观察治疗前后主要临床症状和患者血浆一氧化氮(NO)、内皮素(ET)的变化.结果:治疗组临床总有效率为(88.10%)显著高于对照组(67.47%),(P<0.05);治疗组治疗后血浆NO水平上升,ET值下降,与对照组比较有显著性差异(P<0.05).结论:灯盏花素注射液合脑活素治疗脑动脉硬化症疗效显著.

  4. 不同糖调节受损状态对早期动脉粥样硬化的影响%Association between different impaired glucose regulation and the early-stage arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    赵静; 梁军; 窦连军; 龚莹; 腾飞

    2012-01-01

    目的:探讨糖尿病前期不同血糖水平对颈-股动脉脉搏波传导速度(carotid-to-femoral pulse wave velocity,c-f PWV)的影响.方法:对5 098例非糖尿病者的空腹血糖、口服葡萄糖耐量试验2小时血糖 (2-hour oral glucose tolerance test,2h OGTT)、糖化血红蛋白(hemoglobin A1c,HbA1c)和c-f PWV水平进行分析.结果:空腹血糖受损(impaired fasting glucose,IFG)组、糖耐量受损 (impaired glucose tolerance,IGT)组和高HbA1c组与糖耐量正常组的c-f PWV差异分别为0.97 m/s、1.08 m/s 和 0.92 m/s,差异有统计学意义(P<0.01).高HbA1c合并IFG、高HbA1c合并IGT的c-f PWV明显高于单纯高HbA1c(P=0.036,P=0.03).IFG合并高HbA1c、IGT合并高HbA1c的c-f PWV明显高于单纯IFG 和单纯IGT (P=0.02,P=0.04).结论:c-f PWV水平与糖尿病前期相关联,并独立于其他代谢因素.IFG合并高HbA1c、IGT合并高HbA1c对c-f PWV水平的影响呈叠加效应,提示糖尿病前期不同糖调节受损状态均可引起血管弹性的改变,导致早期动脉粥样硬化发生.%Objective: To explore the associations of glucose exposure and carotid-to-femoral pulse wave velocity ( c-f PWV ) in prediabetes adults. Methods: Fasting plasma glucose, 2-hour oral glucose tolerance test ( 2h OGTT ), hemoglobin Alc( HbAlc ) and c-f PWV were analysed in 5 098 non-diabetes subjects. Results: We found that the differences in c-f PWV between individuals with impaired fasting glucose ( IFG ), impaired glucose tolerance ( IGT ), high HbAlc and those without these abnormalities were 0. 97 m/s, 1. 08 m/s and 0. 92 m/s ( P <0. 01 ). In addition, our data indicated that individuals of both high HbAlc and IFG or IGT had significantly higher levels of c-f PWV compared with those who only had high HbAl c ( P = 0. 036 and 0. 03 , respectively ); or those only had IFG ( P - 0. 02 ); or only had IGT ( P = 0.04 ). Conclusion: c-f PWV was associated with prediabetes, independent of metabolic risk factors. We found that individuals of both high HbAlc and IFG or IGT had additive effects on c-f PWV, and all these alterations may contribute to development and progression of atherosclerosis.

  5. Test de marcha de seis minutos en niños con bronquiolitis obliterante postviral: Correlación con espirometría Six minute walk test in children with post-infectious obliterans bronchiolitis: Its relation with spirometry

    OpenAIRE

    DANIEL ZENTENO A; HOMERO PUPPO G; RAMIRO GONZÁLEZ V; DOLORES PAVÓN T; ROBERTO VERA U; RODRIGO TORRES C; CHUNG KUO K; MARÍA ANGÉLICA PÉREZ H; GUIDO GIRARDI B

    2008-01-01

    la Bronquiolitis Obliterante (BO) postviral produce alteraciones en la función pulmonar que pueden repercutir en la capacidad para realizar ejercicio, la cual se puede evaluar con el test de marcha de 6 minutos (TM6). Objetivo: Estudiar con esta prueba a niños con BO postviral y determinar la relación entre variables espirométricas y los resultados del TM6. Veintisiete pacientes, se estudiaron con espirometría basal y TM6. Se relacionaron variables espirométricas con resultados del TM6: dista...

  6. Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans

    OpenAIRE

    Rita Mattiello; Javier Mallol; Gilberto Bueno Fischer; Helena Teresinha Mocelin; Belkys Rueda; Edgar Enrique Sarria

    2010-01-01

    OBJETIVO: Descrever a função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa (BOPI) e avaliar potenciais fatores de risco para pior função pulmonar. MÉTODOS: A função pulmonar de 77 participantes, com idades de 8-18 anos, foi avaliada por meio de espirometria e pletismografia. Os seguintes parâmetros foram analisados: CVF, VEF1, FEF25-75%, VEF1/CVF, VR, CPT, VR/CPT, volume de gás intratorácico e specific airway resistance (sRaw, resistência específica das vias ...

  7. 儿童闭塞性细支气管炎的临床表现与高分辨率CT特点%Clinical manifestations and high resolution CT features of bronchiolitis obliterans

    Institute of Scientific and Technical Information of China (English)

    周俊霖; 丁山; 朱晓华; 郑巍

    2012-01-01

    Objective To study the clinical manifestations and high resolution CT( HRCT) characteristics of bronchiolitis obliter-ans(BO) , so that to improve the understanding of it. Methods Clinical and CT data in 27 patients(22 boys and 5 girls, aged from 2 months to 5 years, and mean age 15. 4 months) with clinical confirmation of BO were retrospectively analysed. All the patients pres-ented with persistent cough and asthma. All cases underwent chest radiograph, HRCT examinations and blood gas analysis. 10 ca-ses and 5 cases underwent bronchoscopy and pulmonary function test, respectively. Results In 27 cases,24 cases were post-infec-tions BO and the others were premature infants after injury of lungs. Hypoxemia in 14 cases and respiratory failure in 4 cases were showed by blood gas analysis. Ten cases who underwent bronchoscopy showed chronic endobronchial infection. HRCT features in-cluded direct signs (peripheral bronchiectasis and bronchial wall thickening in 16 cases, centrilobular nodules in 5 cases) and indirect signs(bronchiectasis and bronchial wall thickening in 20 cases, air trapping signs in 5 cases, mosaic perfusion signs in 25 cases, con-solidation in 10 cases and atelectasis in 5 cases). Conclusion In most of the patients with BO present following infections. HRCT is of important value in the early diagnosis and evaluation of outcome of BO.%目的 探讨闭塞性支气管炎(BO)的临床表现与高分辨率CT(HRCT)特点,提高对本病的认识.方法 回顾性分析27例经临床诊断证实的儿童闭塞性细支气管炎的临床和CT资料,年龄2个月~5岁,平均15.4月,男22例,女5例.反复咳喘病程均在6周以上.27例患儿均行X线胸片,肺部高分辨率CT及血气分析.10例行电子纤维支气管镜检查,5例行肺功能检查.结果 27例确诊为BO患儿,3例为早产儿肺损伤后,余24例为感染后.血气分析示低氧血症14例,呼吸衰竭4例.10例行电子纤维支气管镜检查均提示有支气管内膜慢性感染.肺部高分辨CT检查,直接征象:外周细支气管扩张、管壁增厚(16例);小叶中心性支气管结节影(5例).间接征象:大支气管扩张、管壁增厚(20例);空气潴留征(5例)和马赛克灌注征(25例);肺实变(10例)、肺膨胀不全(5例).结论 儿童BO多为感染后起病,HRCT对该病的早期诊断及预后评价具有重要价值.

  8. Bronquiolite obliterante pós-infecciosa: aspectos clínicos e exames complementares de 48 crianças Post-infectious bronchiolitis obliterans: clinical aspects and complementary testing of 48 children

    OpenAIRE

    Rosaly Vieira dos Santos; Rosário, Nelson A.; Carlos Antônio Ried

    2004-01-01

    INTRODUÇÃO: A evolução clínica da bronquiolite obliterante pós infecciosa é variável. OBJETIVO: Verificar as características clínicas, a evolução e os exames complementares de 48 pacientes com bronquiolite obliterante (BO) pós-infecciosa. MÉTODO: Estudo observacional e retrospecitvo. O diagnóstico de bronquiolite obliterante foi baseado em critérios clínicos, tomográficos e pela exclusão de outras doenças. Avaliou-se a história prévia ao diagnóstico e exames complementares. A saturação arteri...

  9. Función pulmonar y calidad de vida en niños y adolescentes con bronquiolitis obliterante por adenovirus Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection

    OpenAIRE

    Stefhanie Nayar E; Mónica Saavedra B; Ana María Escobar C; Alberto Vidal G

    2011-01-01

    Introducción: La infección por adenovirus es una causa importante de neumonía en niños chilenos. La bronquiolitis obliterante (BOPI) es la complicación más importante. Existen pocos estudios donde evalúen la función pulmonar y la calidad de vida de los pacientes con BOPI. Objetivo: Evaluar la función pulmonar y la calidad de vida de los pacientes con BOPI y la correlación entre ambas variables. Métodos: Se incluyeron 14 niños con BOPI en elpoliclínico de la unidad de broncopulmonar de un hosp...

  10. Intravenous prostacyclin analogue iloprost (Ilomedin® in the treatment of a patient with Buerger’s disease

    Directory of Open Access Journals (Sweden)

    Ilshat Ravilevich Gaisin

    2013-01-01

    Full Text Available Buerger’s disease, or thromboangiitis obliterans, is a severe disabling systemic disease of vessels. The paper describes a case of thromboangiitis obliterans in a patient with three extremities amputated during vascular therapy. The course intravenous administration of the stable prostacyclin analogue iloprost (Ilomedin® allows the only extremity to be preserved.

  11. Bone marrow stem cell injection for the treatment of critical limb ischemia

    Directory of Open Access Journals (Sweden)

    Shunya Shindo

    2007-01-01

    Full Text Available Vascular reconstruction remains a treatment of choice for critical limb ischemia. Bypass surgery has been accepted as the most effective therapy to achieve increase of blood flow and cure the ischemic symptoms. On the other hand, continuous increase of the patients suffering diabetes mellitus enhances the increase of the number of the patients with peripheral arterial disease (PAD. This tendency is also observed in Japan and expected to continue from now on. The reports of the Ministry of Health, Labor and Welfare of Japan indicated that more than 6% of population was treated for diabetes mellitus and more than 12% of population was supposed to be diabetic in 2002.1 This report also gave a warning for rapid and continuous increase of the diabetic patients at present and in the future.? As is well known, diabetes mellitus is one of the strong risk factors to cause an arteriosclerosis obliterans (ASO. Therefore, the patients with PAD will increase continuously and more severe ischemic limb will need to be treated. Moreover, diabetic macroangiopathy is characterized as showing diffuse stenosis and occlusion down to the foot arteries.2 Monckeberg’s medial calcification is also frequently observed in the ASO with diabetes mellitus.3 Therefore, along with the increase of the patients with PAD, the vascular reconstruction becomes technically demanding due to co-morbid diabetes with diffuse lesion and severe calcification. The patients, who show critical limb ischemia but are excluded from the operative candidate, are eventually performed major amputation. To prevent this disastrous sequel, therapeutic angiogenesis has been investigated.In 1996, Isner reported a new therapy to treat ischemic limb by using angiogenetic gene; vascular endothelial growth factor (VEGF.4 Since then, angiogenetic therapy started to be investigated by using gene transfer with VEGF, fibroblast growth factor (FGF5 or hepatic growth factor (HGF.6 Animal study showed increase of

  12. A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

    Science.gov (United States)

    2016-07-20

    Ischemia; Peripheral Arterial Disease; Peripheral Vascular Disease; Vascular Disease; Arterial Occlusive Disease; Arteriosclerosis; Atherosclerosis; Cardiovascular Disease; Pathologic Processes; Orthopedic Procedures; Amputation

  13. Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery

    Science.gov (United States)

    2016-07-05

    Complications Due to Coronary Artery Bypass Graft; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

  14. Central Obesity and Disease Risk in Japanese Americans

    Science.gov (United States)

    2016-02-08

    Cardiovascular Diseases; Heart Diseases; Atherosclerosis; Hypertension; Obesity; Diabetes Mellitus, Non-insulin Dependent; Hyperinsulinism; Insulin Resistance; Coronary Arteriosclerosis; Diabetes Mellitus; Metabolic Syndrome X

  15. An international ISHLT/ATS/ERS clinical practice guideline:

    DEFF Research Database (Denmark)

    Meyer, Keith C; Raghu, Ganesh; Verleden, Geert M;

    2014-01-01

    Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that is associated with poor survival. The International Society for Heart and Lung Transplantation, American Thoracic Society, and European Respiratory Society convened a committee of international experts...

  16. ABI与CAVI评价原发性高血压患者血压控制不良对动脉硬化影响的研究%ABI and CAVI in assessment of arteriosclerosis progress in primary hypertensive patients with poor blood pressure control

    Institute of Scientific and Technical Information of China (English)

    朱利月; 任爱华; 俞志红; 寿晓玲; 王雁; 刘新文

    2015-01-01

    目的 探讨踝-臂指数(ABI)与心踝指数(CAVI)评价原发性高血压患者血压控制不良对动脉硬化影响的临床应用价值.方法 原发性高血压患者105例,根据24h动态血压结果,分为高血压控制达标组46例和高血压控制不良组59例,另择同期行健康体检者41例为正常对照组,分别测定3组的CAVI、ABI、BMI值并进行两两比较.结果 3组比较结果显示:CAVI、ABI、BMI值差异均有统计学意义(均P<0.05);其中血压控制不良组双侧CAVI值明显增高,双侧ABI值明显降低,BMI值增高,差异均有统计学意义(均P<0.05);而高血压控制达标组与正常对照组比较双侧CAVI、双侧ABI、BMI值差异均无统计学意义(均P>0.05).结论 血压控制不良将促进动脉硬化进展,应用ABI与CAVI值可准确评价高血压控制不良对动脉弹性的影响.

  17. Impact of different lipid lowering scheme on the liver and kidney function and endothelial function in arteriosclerosis rats model%不同调脂方案对动脉硬化大鼠肝肾功能及血管内皮功能的影响

    Institute of Scientific and Technical Information of China (English)

    徐艳玲; 张静; 周琳

    2013-01-01

    Objective To investigate vascular endothelial function,liver function and renal function of mixed hyperlipidemia rats treated by different ways including high doses of simvastatin and small doses of simvastatin combined with ezetimibe.Methods Forty-two healthy Wistar 6-month-old male rats were randomly divided into five groups,including normal control group (n =8),hyperlipidemia control group (n =10),low dose of simvastatin [10 mg/(kg · d)] group (n =8),high dose of simvastatin [20 mg/(kg · d)] group (n =8),simvastatin [10 mg/(kg · d)] combined with ezetimibe [5 mg/(kg · d)] group (n =8).Levels of total cholesterol (TC),lowdensity lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides (TG),alanine aminotransferase (ALT),aspartate aminotransferase (AST),serum creatinine (Scr),urea nitrogen (BUN),uric acid,urine protein,urine creatinine (Ucr),serum creatinine clearance rate (Ccr),C-reactive protein (CRP),soluble thrombomodulin regulatory proteins (sTM) and soluble intercellular adhesion molecule-1 (sICAM-1) and urinary protein were tested in all groups.Renal index was also calculated.Results ① Compared with hyperlipidemia control group,levels of TC,IDL-C,TG,ALT,AST,BUN,uric acid,urine protein,CRP,sTM and sICAM-1 in all the therapeutic groups were significantly lower (P <0.01).But HDL-C and Ccr levels were significantly higher.Renal function were improved and levels of sTM and slCAM-1 were significantly lower (P < 0.01) in high dose of simvastatin [20 mg/(kg· d)] group.Liver function were improved and limpid-lowering were better in simvastatin [10 mg/(kg · d)] combined with ezetimibe [5 mg/(kg · d)] group.②Small size of glomerular and mesangial cell proliferation relief were seen in the therapeutic groups with light microscope.And high dose of simvastatin group had better results.Conclusions ①Compared with simvastatin combined with ezetimibe group,high dose of simvastatin treatment has lower levels of BUN,uric acid,urine protein,sTM and sICAM-1,can reduce renal index,increase Ccr and HDL-C levels,improve glomerular morphology and improve renal function and vascular endothelial function.②Compared with high-dose simvastatin group,small doses of simvastatin and ezetimibe treatment can significantly reduce TC,LDL-C and CRP levels,don't affect serum transaminase levels,and reduce lipid effectively but not increase damage of liver function.%目的 探讨单用较大剂量辛伐他汀与小剂量辛伐他汀联合依折麦布对动脉硬化大鼠血管内皮功能及肝肾功能的影响.方法 将42只健康6月龄Wistar雄性大鼠完全随机分为正常对照组(n=8)、高脂对照组((n=10)、辛伐他汀低剂量组[10 mg/(kg·d),n=8]、辛伐他汀高剂量组[20 mg/(kg·d),n=8)]和辛伐他汀[10 mg/(kg·d)]联合依折麦布[5 mg/(kg·d)]组(n=8),给予相应剂量的辛伐他汀及依折麦布灌胃.分别于实验第8周末眼静脉丛采血及第12周末心脏采血后测定各组大鼠TC、LDL-C、HDL-C、TG、ALT、AST、血清肌酐(Scr)、BUN、尿酸、尿蛋白、尿肌酐(Ucr)、血清肌酐清除率(Ccr)、C反应蛋白(CRP)、可溶性血栓调节蛋白(sTM)和可溶性细胞间黏附因子1(sICAM-1)水平及尿蛋白浓度,并计算肾指数.结果 ①辛伐他汀低剂量组、高剂量组,辛伐他汀联合依折麦布组较高脂对照组TC、LDL-C、TG、ALT、AST、BUN、尿酸、尿蛋白、CRP、sTM、sICAM-1水平明显降低(P<0.01),HDL-C及Ccr水平升高,其中辛伐他汀高剂量组肾功能明显改善[实验12周末血Scr:(2.00±0.47) ml/min比(0.55±0.12) ml/min,BUN:(5.25±0.50) mmol/L比(7.82±0.25) mmol/L,尿酸:(81±17) μmol/L比(142±13) μmol/L,尿蛋白:(1.98±0.18) g/L比(2.89±0.32) g/L]、sTM、sICAM-1水平明显降低[实验12周末sTM:(165±26) g/L比(279±30) g/L,sICAM-1:(20.1±3.2)g/L比(48.1±6.4)g/L],辛伐他汀联合依折麦布组血脂及肝功能明显改善.②光镜下:各处理组肾小球体积小,系膜细胞增生减轻,且均以辛伐他汀高剂量组改善明显.结论 ①单用较大剂量辛伐他汀与小剂量辛伐他汀联合依折麦布相比,能更好降低BUN、尿酸、尿蛋白、sTM和sICAM-1水平,降低肾指数,提高Ccr和HDL-C水平,改善肾小球形态,从而起到改善肾功能及血管内皮功能的作用.②小剂量辛伐他汀联合依折麦布较单用大剂量辛伐他汀更能显著降低TC、LDL-C和CRP水平,且不增加血清转氨酶水平,有效降脂的同时不增加肝功能损害.

  18. 硒对高氟所致兔血管内皮损伤及动脉硬化影响的病理形态学研究%Pathological morphology of vascular endothelial injury and arteriosclerosis caused by high fluoride and the effects of selenium

    Institute of Scientific and Technical Information of China (English)

    边建朝; 杨晓霞; 蔺新英; 朱秋丽; 樊婷

    2010-01-01

    Objective To study morphological changes of rabbit artery endothelial cell injury and atherosclerosis caused by high fluoride and the role of selenium. Methods Twenty healthy male New Zealand white rabbits, body weight (2.0 ± 0.5)kg, were randomly divided into control group(drinking deionized water, fed basic diet), fluoride group(drinking fluoride 100 mg/L deionized water, fed basic diet), selenium group(drinking selenium 1 mg/L deionized water, fed basic diet), fluoride plus selenium group(drinking fluoride 100 mg/L deionized water, selenium 1 mg/L of deionized water, fed basic diet). The experimental period was 6 months. At 0, 3, 6 months of the experiment, serum fluorine and selenium levels were determined. At the end of the experiment,thoracic aorta was collected to observe its pathology and ultrastructural changes. Results Serum fluoride was significantly higher at the 3rd and the 6th month of experiment(all P < 0.01 ) in fluoride group[ (0.589 ± 0.146),(0.772 ± 0.175)mg/L] and fluoride plus selenium group[ (0.502 ± 0.094), (0.693 ± 0.158)mg/L] than in control group[ (0.174 ± 0.002), (0.208 ± 0.031 )mg/L] and serum fluoride was significantly higher at 6 months than at 3 months(P < 0.05 ) in fluoride group. Serum selenium was significantly higher at the 3rd and the 6th month of experiment (all P < 0.01 ) in selenium group[ (0.252 ± 0.022), (0.319 ± 0.052)mg/L] and fluoride plus selenium group[ (0.239 ±0.016), (0.294 ± 0.018)mg/L] than in control group[(0.135 ± 0.014), (0.167 ± 0.019)mg/L], and serum selenium was significantly higher at the 6th month than at 3rd month of experiment in selenium group(P < 0.05). Endothelial cell apoptosis indices were (4.92 ± 1.32)%, (30.30 ± 6.80)%, (6.57 ± 2.14)% and (14.29 ± 2.99)%, respectively in control group, fluoride group, selenium group and fluoride plus selenium group. Their main effect of fluorine and selenium was statistically significant (F = 106.833,20.082, all P < 0.01 ). There were antagonistic effect between fluoride and selenium(F = 30.402, P < 0.01 ). Pathological changes of rabbit aortic endothelial cells in fluoride group included endothelial with attached fibrin and red blood cells, and structural of the cells changed, with serious vascular injury; in fluoride plus selenium group apoptosis of endothelial cells decreased, with reduced number of attached red blood cells and fibrin, endothelial cell structure normal, the extent and scope of vascular damage significantly reduced. Conclusions Appropriate amount of selenium inhibits the apoptosis of endothelial cells induced by high fluoride, reduces aortic structural damage caused by high fluoride, and maintains the integrity of endothelial cells, thereby antagonizes the vascular damage and atherosclerosis induced by high fluoride.%目的 研究硒对高氟所致兔动脉血管内皮细胞损伤和动脉硬化病理形态学变化的影响作用.方法 20只健康雄性新西兰白兔,体质量(2.0±0.5)kg,按体质量随机分对照组(饮去离子水,饲基础饲料)、加氟组(饮含氟离子100mg/L去离子水,饲基础饲料)、加硒组(饮含硒1 mg/L去离子水,饲基础饲料)、加氟加硒组(饮含氟离子100 mg/L、含硒1 mg/L去离子水,饲基础饲料),每组5只,实验期6个月.于实验第0、3、6个月取血测定血清含氟量和含硒量;实验终末取胸主动脉,观察主动脉病理及超微结构变化.结果实验第3、6个月时,加氟组和加氟加硒组血清氟[(0.589±0.146)、(0.772±0.175)mg/L和(0.502±0.094)、(0.693±0.158)mg/L]显著高于对照组[(0.174±0.002)、(0.208±0.031)mg/L,P均<0.01];加氟组第6个月血清氟显著高于第3个月(P<0.05).实验第3、6个月时,加硒组和加氟加硒组血清硒[(0.252±0.022)、(0.319±0.052)mg/L和(0.239±0.016)、(0.294±0.018)mg/L]显著高于对照组[(0.135±0.014)、(0.167±0.019)mg/L,P均<0.01];加硒组第6个月血清硒显著高于第3个月(P<0.05).对照组、加氟组、加硒组、加氟加硒组内皮细胞凋亡指数分别为(4.92±1.32)%、(30.30±6.80)%、(6.57±2.14)%和(14.29±2.99)%,氟与硒各自的主效应有统计学意义(F值分别为106.833、20.082,P均<0.01),高氟与适硒之间存在显著的拮抗作用(F=30.402,P<0.01).病理观察加氟组主动脉内皮有红细胞及纤维蛋白沉着,细胞走向及结构发生改变,血管受损严重;加氟加硒组减少内皮细胞凋亡,附着的纤维蛋白以及红细胞数量减少,内皮细胞结构基本正常,血管受损程度和范围明显减轻.结论适量硒抑制高氟引起的内皮细胞凋亡,减轻高氟所致主动脉结构破坏,保持内皮细胞的完整性,以此拮抗高氟对血管的损伤和促动脉粥样硬化作用.

  19. 脐带间充质干细胞移植治疗50例缺血性下肢血管病的临床研究%The Clinical Research of Umbilical Cord Mesenchymal Stem Cells Transplantation in The Treatment of 50 Cases of Lower Limb Vascular Disease

    Institute of Scientific and Technical Information of China (English)

    杜艳; 周毅; 李贞艳; 徐黎鸣; 杜玲

    2013-01-01

    目的:观察脐带间充质干细胞移植治疗缺血性下肢血管病的临床疗效并观察近期临床效果.方法:50例自愿接收脐带间充质干细胞移植患者中糖尿病足35例,动脉硬化闭塞症10例,血栓性闭塞性脉管炎5例.全部患者均给予静脉输注及局部种植脐带间充质干细胞.术后第7天至6个月定期观察各项指标的变化.结果:治疗1月后,47例(94%)疼痛有不同程度的缓解,46例(92%)患肢冷感明显缓解,45例(90%)患者行走距离延长.6月后30例糖尿病足患者溃疡或足部坏疽痊愈.结论:脐带间充质干细胞移植治疗缺血性下肢血管病是一种简便、安全、有效的治疗方法,其治疗的近期疗效显著,使很多患者免除截肢或降低截肢平面,明显改善患者生活质量.%Objective: To investigate the umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic vascular disease the clinical curative effect of the lower limbs watching the recent clinical effect. Methods: Fifty patients with voluntary receiving umbilical cord mesenchymal stem cells transplantation in patients with diabetes foot 35 patients, arteriosclerosis block disease 10 cases, thrombosis obliterans 5 cases. All patients were given intravenous and local planting umbilical cord mesenchymal stem cells. Postoperative seven days to six months each index of change regularly observation. Results: 1 month after treatment, 47 patients (94%) had different degrees of pain relief, 46 cases (92%) limb cold feeling significant relief, 45 patients (90%) patients walking distance to extend. After six months, 30 cases of patients with diabetes foot ulcers or foot gangrene healed. Conclusions: Umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic lower limb vascular disease is a simple, safe and effective in the treatment of method, the treatment of recent curative effect is distinct, making a lot of patients from amputation or reduce

  20. The evaluation of surgical reconstruction for intermittent claudication by the Walking Impairment Questionnaire Avaliação da reconstrução cirúrgica para claudicação intermitente pelo Walking Impairment Questionnaire

    Directory of Open Access Journals (Sweden)

    Masaya Nakashima

    2010-12-01

    Full Text Available BACKGROUND: No standards reflecting the quality of life (QOL and activity of daily living (ADL in postoperative clinical course have been validated in the area of vascular disease. The Walking Impairment Questionnaire (WIQ is a disease-specific questionnaire that evaluates patients with intermittent claudication due to arteriosclerosis obliterans (ASO. The WIQ uses four subscales: pain severity, walking distance, walking speed, and stair climbing while walking. OBJECTIVE: To evaluate the correlation between postoperative arterial blood flow and the Japanese edition of the WIQ. METHODS: Thirty-one patients (47 limbs with intermittent claudication who had been subjected to lower limb surgical arterial reconstruction were assessed by WIQ, and compared with Ankle-Brachial Pressure Index (ABPI and angiography. RESULTS: A significant increase in the WIQ score was identified in walking pain (26 versus 89.5, pINTRODUÇÃO: Nenhum padrão de qualidade de vida e atividades diárias no período pós-operatório já foi validado na área de doenças vasculares. O Walking Impairment Questionnaire (WIQ é um questionário específico para pacientes com claudicação intermitente devido à aterosclerose obliterante. O WIQ se baseia em quatro subescalas: intensidade da dor, distância caminhada, velocidade de caminhada e subir degraus durante caminhada. OBJETIVO: Avaliar a correlação entre fluxo sanguíneo periférico pós-operatório e a edição japonesa do WIQ. MÉTODOS: Trinta e um pacientes (totalizando 47 membros inferiores com claudicação intermitente que se submeteram à reconstrução arterial cirúrgica foram avaliados pelo WIQ e comparados por meio do índice de pressão tornozelo-braço (ITB e angiografia. RESULTADOS: Um aumento significativo no escore do WIQ foi observado em relação à dor durante caminhada (26 versus 89,5, p<0,001, distância caminhada (13,1 versus 83,3, p<0,001, velocidade da caminhada (10 versus 46, p<0,001 e ato de subir

  1. Application of Multislice Spiral CT Angiography in Diagnosis of Arterial Diseases in Body%多层螺旋CT血管成像在体部动脉病变中的应用

    Institute of Scientific and Technical Information of China (English)

    王治民; 徐香玖

    2011-01-01

    目的 评价多层螺旋CT血管成像(MSCTA)在体部动脉性病变诊治中的应用价值.方法 68例经手术病理证实的体部动脉病变患者行MSCTA检查,其中颈部35例,胸腹主动脉及其分支23例,双下肢动脉10例.应用多平面重建(MPR),曲面重建(CPR),最大密度投影(MIP),容积显示技术(VRT)以及血管分析(VA)软件进行图像重建及分析.结果 68例体部动脉病变中,CTA 显示颈动脉钙化斑块伴狭窄25例,颈内动脉闭塞1例,颈总动脉假性动脉瘤1例,颈动脉鞘内神经源性肿瘤伴血管推移2例,椎动脉钙化狭窄5例,椎动脉瘤1例.胸、腹主动脉瘤5例,假性动脉瘤8例,主动脉夹层10例,双下肢动脉硬化性闭塞症9例及下肢血管动静脉瘘1例.结论多层螺旋CT血管成像对体部动脉病变的临床诊治具有重要指导意义.%Objective To evaluate the value of multislice spiral CT angiogrpahy(MSCTA) in diagnosis of arterial diseases in body. Methods MSCTA was performed in 68 patients with artery diseases proved by surgery-pathology,including neck in 35 cases,thoracic and abdominal aorta and it's main branches in 23 cases and bilateral lower extremity artery in 10 cases. The lesions of arteriae were analysed with reconstructed images including MPR,CPR,MIP,VRT and VA. Results MSCTA demonstrated carotid artery calcification with stenosis in 25 cases,internal carotid artery occlusion in 1 case, false aneurysm of common carotid artery in 1 case, neurogenic tumor of carotid sheath in 2 cases, vertebral artery calcification with stenosis in 5 cases,vertebral artery aneurysm in 1 case,aneurysm of thoracic and abdominal artery in 5 cases, false aneurysm of thoracic and abdominal artery in 8 cases,dissection of thoracic and abdominal aorta in 10 cases,arteriosclerosis obliterans bilateral lower extremities in 9 cases and arteriovenous fistula of bilateral lower extremities vessels in 1 case. Conclusion MSCTA examination is of significant value in diagnosing

  2. Guía clínica para el diagnóstico y cuidado de niños/adolescentes con bronquiolitis obliterante post-infecciosa, 2009 Clinical guide for diagnosis and care of children and adolescents with post-infectious bronchiolitis obliterans, 2009

    OpenAIRE

    Luis E Vega-Briceño; DANIEL ZENTENO A

    2009-01-01

    La bronquiolitis obliterante (BO) es un síndrome clínico poco frecuente en niños, caracterizado por la obstrucción crónica al flujo de aire asociado a cambios inflamatorios y distintos grados de fibrosis en la vía aérea pequeña. Si bien existen muchas etiologías, la causa más frecuente se asocia a infecciones respiratorias virales, principalmente adenovirus. No existe un consenso para establecer su diagnóstico; sin embargo, se considera un espectro de síntomas persistentes asociados a un patr...

  3. Tissue Characterization on Common Carotid Artery using AR Model

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    This study uses one image with a echocardiography and detects arteriosclerosis on the common carotid artery by tissue characterization. The conventional methods are measurement of thickness on the vessel wall or stiffness on the common carotid artery. However, they need frames of several beats and great calculation times. But, we detect the arteriosclerosis with only one image. Our method estimate the grade of arteriosclerosis by AR model parameters fitted to the texture on the lumen-intima wall. Experimental results show the validity of the proposed method.

  4. Ankyloserende spondylitis er associeret med øget kardiovaskulær morbiditet og mortalitet

    DEFF Research Database (Denmark)

    Madsen, Ole Rintek; Lindhardsen, Jesper

    2011-01-01

    Ankylosing spondylitis is an inflammatory disorder primarily affecting the axial skeleton. The disease is associated with increased cardiovascular morbidity and mortality. Structural changes in the heart, and arteriosclerosis secondary to inflammation may be of importance. The role of traditional...

  5. Betaine-homocysteine methyltransferase (BHMT) : genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans

    NARCIS (Netherlands)

    Heil, S.G.; Lievers, K.J.A.; Boers, G.H.; Verhoef, P.; Heijer, den M.; Trijbels, F.J.M.; Blom, H.J.

    2000-01-01

    Elevated homocysteine levels have been associated with arteriosclerosis and thrombosis. Hyperhomocysteinemia is caused by altered functioning of enzymes of its metabolism due to either inherited or acquired factors. Betaine-homocysteine methyltransferase (BHMT) serves, next to methionine synthase, a

  6. Breast arterial calcifications : A systematic review and meta-analysis of their determinants and their association with cardiovascular events

    NARCIS (Netherlands)

    Hendriks, Eva J E; de Jong, Pim; van der Graaf, Yolanda; Mali, Willem P Th M; van der Schouw, Yvonne T.; Beulens, Joline W J

    2015-01-01

    Objective: Breast arterial calcifications (BAC), regularly observed at mammography, are medial calcifications and as such an expression of arteriosclerosis. Our objective was to evaluate and summarize the available evidence on the associations of BAC with cardiovascular risk factors and cardiovascul

  7. On Two Hearts and Other Coronary Reflections.

    Science.gov (United States)

    Flannery, Maura C.

    1998-01-01

    Speculates as to how understanding of heart disease has developed and provides insight into how medical science makes progress. Summarizes the state of knowledge on arteriosclerosis, heart attacks, and exercising the heart. Contains 23 references. (DDR)

  8. Triglyceride level

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003493.htm Triglyceride level To use the sharing features on this page, ... and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney ...

  9. The effect of different immunosuppressants on alloantigen dependent and independent factors involved in the development of chronic rejection in an animal model.

    OpenAIRE

    Cole, O.; Rigg, K.; Shehata, M

    2001-01-01

    The aim of this study was to compare the effects of cyclosporine, tacrolimus, mycophenolate mofetil and SDZ RAD on an animal model of transplant arteriosclerosis involving alloantigen dependent and independent mechanisms.

  10. Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study

    Science.gov (United States)

    2016-02-05

    Atherosclerosis; Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Cerebrovascular Disorders; Heart Failure, Congestive; Myocardial Infarction; Heart Diseases; Diabetes Mellitus, Non-insulin Dependent; Hypertension; Diabetic Retinopathy; Macular Degeneration; Diabetes Mellitus

  11. Multidisciplinary Inpatient Palliative Care Intervention

    Science.gov (United States)

    2006-05-12

    Cerebrovascular Accident; Cancer; Coronary Arteriosclerosis; Heart Failure, Congestive; Diabetes Mellitus; Acquired Immunodeficiency Syndrome; Failure to Thrive; Pulmonary Disease, Chronic Obstructive; Dementia; Kidney Failure, Chronic; Pneumonia; Liver Failure; Renal Failure; Respiratory Failure; Stroke

  12. Rheumatoid arthritis and cryptogenic organising pneumonitis.

    Science.gov (United States)

    Rees, J H; Woodhead, M A; Sheppard, M N; du Bois, R M

    1991-05-01

    We describe three patients with rheumatoid arthritis who presented with non-specific pulmonary symptoms, a restrictive defect in lung function and bilateral changes on chest radiograph. Lung histology showed characteristic features of cryptogenic organising pneumonitis and treatment with steroids produced significant improvement. The clinical and laboratory features of cryptogenic organising pneumonitis (otherwise known as bronchiolitis obliterans organising pneumonia, 'BOOP') are discussed and compared with those of bronchiolitis obliterans with which the condition should not be confused. Cryptogenic organising pneumonitis should be considered as one of the pulmonary manifestations of rheumatoid arthritis, but lung biopsy is essential to make the diagnosis.

  13. HRCT findings of chest complications in patients with leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Nobuyuki; Matsumoto, Tsuneo; Miura, Gouji; Emoto, Takuya; Matsunaga, Naofumi [Department of Radiology, Yamaguchi University School of Medicine (Japan)

    2002-06-01

    High-resolution CT (HRCT) findings of several chest complications occurring in leukemic patients were reviewed. Although most entities show non-specific HRCT findings including ground-glass opacity and air-space consolidation, characteristic findings are observed in several pulmonary complications including Pneumocystis carinii pneumonia, fungal infections, miliary tuberculosis, leukemic infiltration, pulmonary edema, bronchiolitis obliterans, and bronchiolitis obliterans organizing pneumonia. A combination of these characteristic HRCT findings and the information obtained from the clinical setting may help in achieving a correct diagnosis of chest complications occurring in leukemic patients. (orig.)

  14. A N UNUSUAL CASE OF SWYER - JAMES - MACLE O DS SYNDROME WITH DEXTROCARDIA

    Directory of Open Access Journals (Sweden)

    Sahana

    2015-05-01

    Full Text Available Swyer - James/MacLeod S yndrome ( SJMS is an uncommon disease with the haracteristic radiological feature of "unilateral hyperlucency" due to loss of pulmonary vasculature and air trapping . SJMS is considered to be a form of bronchiolitis obliterans that fol lows viral bronchiolitis and pneumonitis . This report describes a rare case of Swyer - James syndrome with dextrocardia diagnosed in a 3 year s old child during evaluation for recurrent respiratory infections . KEYWORDS : Swyer - James/MacLeod syndrome ; Unilateral Hyperlucency ; Bronchiolitis obliterans ; Chest X - ray ; Dextrocardia .

  15. Potential of advanced photoplethysmography sensing for noninvasive vascular diagnostics and early screening

    Science.gov (United States)

    Spigulis, Janis; Kukulis, Indulis; Fridenberga, Eva; Venckus, Girts

    2002-06-01

    Advanced sensor device for shape analysis of the tissue- reflected mean single period photoplethysmography (SPPPG) signals has been designed and clinically tested. The SPPPG signal shape reveals individual features of the patient's cardio-vascular state. Clinical studies of several patient groups (e.g. diabetes mellitus, atherosclerosis obliterans, Raynaud's syndrome) made possible to specify components of the SPPPG signal that are sensitive to the corresponding organic or functional pathologies. Comparison of the right and left arm finger SPPPG signal shapes, for instance, appears to be efficient tool for early screening of unilateral atherosclerosis obliterans.

  16. Pulmonary retransplantation in the Nordic countries

    DEFF Research Database (Denmark)

    Lindstedt, Sandra; Dellgren, Göran; Iversen, Martin;

    2015-01-01

    years (range, 22 to 64 years) underwent re-LTx from 1992 until June 2013, of which 53 had single re-LTx, 21 had double re-LTx, and 1 patient underwent a heart-lung retransplantation. Primary graft dysfunction (PGD) was the primary indication in 9 cases, bronchiolitis obliterans syndrome (BOS) in 62...

  17. Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells

    DEFF Research Database (Denmark)

    Rolandsson, Sara; Andersson Sjöland, Annika; Brune, Jan C;

    2014-01-01

    . This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients. METHODS: Primary lung MSC were directly isolated or culture-derived from central...

  18. 闭塞性毛细支气管炎1例

    Institute of Scientific and Technical Information of China (English)

    朴香淑

    2009-01-01

    @@ 1901年德国病理学家Lange首次报道并命名了闭塞性毛细支气管炎(bronchiolitis obliterans,BO)[1].吉林省通化市人民医院收治了1例闭塞性毛细支气管炎.现报道如下:

  19. Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus with unusual manifestations and without detectable autoantibodies

    Directory of Open Access Journals (Sweden)

    Jimena Sanz-Bueno

    2014-01-01

    Full Text Available We describe a patient with paraneoplastic autoimmune multiorgan syndrome (PAMS secondary to a lymphoblastic T- cell lymphoma who presented with a lichenoid dermatitis and vitiligo, later developing bronchiolitis obliterans and autoimmune hepatitis. Notably, he had no detectable autoantibodies. The development of vitiligo and autoimmune hepatic involvement probably indicate a role for cytotoxic T- cell lymphocytes in the pathogenesis of this syndrome.

  20. Banff study of pathologic changes in lung allograft biopsy specimens with donor-specific antibodies

    DEFF Research Database (Denmark)

    Wallace, William Dean; Li, Ning; Andersen, Claus B;

    2016-01-01

    -DSAs, and no antibodies (NABs) present. The significance of each histologic variable was reviewed. RESULTS: We found no statistically significant association with acute cellular rejection, airway inflammation, or bronchiolitis obliterans and the presence or absence of antibodies. However, biopsy specimens with DSAs had...

  1. The value of ventilation scintigraphy after single lung transplantation

    NARCIS (Netherlands)

    Ouwens, JP; van der Bij, W; van der Mark, TW; Piers, DA; Koeter, GH

    2004-01-01

    Background: A decrease in forced expiratory volume in 1 second (FEV1) as a diagnostic criterion for bronchiolitis obliterans syndrome (BOS) after single lung transplantation may be influenced significantly by the presence of the native lung. To quantify and to discriminate between the relative contr

  2. Chronic lung allograft dysfunction after lung transplantation: novel insights into immunological mechanisms

    NARCIS (Netherlands)

    Budding, K.

    2016-01-01

    Lung transplantation (LTx) is the final treatment option for patients suffering from end-stage lung diseases. Survival after LTx is hampered by the development of chronic lung allograft dysfunction which presents itself in an obstructive form as the bronchiolitis obliterans syndrome (BOS). BOS is ha

  3. Tortuous Common Carotid Artery: A Report of Four Cases Observed in Cadaveric Dissections

    Directory of Open Access Journals (Sweden)

    Joe Iwanaga

    2016-01-01

    Full Text Available A tortuous common carotid artery poses a high risk of injury during tracheotomy. Preoperative diagnosis is therefore important to avoid serious complications. We found four cases of tortuous common carotid artery during an anatomical dissection course for students. The first case was a 91-year-old woman who had bilateral tortuous common carotid arteries without arteriosclerosis. Case 2 was a 78-year-old woman who had bilateral tortuous common carotid arteries without arteriosclerosis. Case 3 was an 86-year-old woman who died from bladder cancer and who also had a right tortuous common carotid artery without arteriosclerosis. Case 4 was an 89-year-old woman who had bilateral tortuous common carotid arteries and a tortuous brachiocephalic artery with severe arteriosclerosis. Case 4 was also examined using computed tomography to evaluate the arteriosclerosis. Computed tomography revealed severe calcification of the vascular wall, which was confirmed in the aortic arch and origins of its branches. In all four cases, the tortuosity was located below the level of the thyroid gland. Based on prior study results indicating that fusion between the carotid sheath and visceral fascia was often evident at the level of the thyroid gland, we speculated that the major region in which tortuosity occurs is at the same level or inferior to the level of the thyroid gland.

  4. Assessment of intra and extra cranial atherosclerosis in coronary artery disease. Advantage of MRI/MRA

    International Nuclear Information System (INIS)

    The incidence of arteriosclerosis has increased in recent years as the aging population has grown. We carried out the present study to investigate the association of internal carotid arteriosclerosis, sclerosis of intracranial main arteries, and cerebral arteriolosclerosis to coronary arteriosclerosis using MRI and MRA in a total of 133 consecutive patients (107 males and 26 females), who visited our hospital with a main complaint of chest pain. We also examined serum lipids and the presence or absence of hypertension and/or diabetes. Coronary arteriosclerosis underlying atherosclerotic lesions was correlated with internal carotid arteriosclerosis, serum cholesterol and low HDL cholesterol level. As characteristic findings of this study, lacunar infarction (LI), which is thought to represent cerebral arteriolosclerosis, was not only significantly correlated with age and hypertension, but increased also lacunar infarcts in number as the number of affected coronary branches increased. Examination of the cases of severe coronary artery disease with MRI/MRA was thought to be able to predict the occurrence of cerebrovascular disorder after CABG and to be useful for the selection of a therapeutic regimen, such as PTCA and MID-CABG. (author)

  5. Assessment of intra and extra cranial atherosclerosis in coronary artery disease. Advantage of MRI/MRA

    Energy Technology Data Exchange (ETDEWEB)

    Kondo, Hirohide; Oda, Yoshinori; Hirai, Akio; Ibukiyama, Chiharu; Utsugi, Osamu [Tokyo Medical Coll. (Japan)

    1999-02-01

    The incidence of arteriosclerosis has increased in recent years as the aging population has grown. We carried out the present study to investigate the association of internal carotid arteriosclerosis, sclerosis of intracranial main arteries, and cerebral arteriolosclerosis to coronary arteriosclerosis using MRI and MRA in a total of 133 consecutive patients (107 males and 26 females), who visited our hospital with a main complaint of chest pain. We also examined serum lipids and the presence or absence of hypertension and/or diabetes. Coronary arteriosclerosis underlying atherosclerotic lesions was correlated with internal carotid arteriosclerosis, serum cholesterol and low HDL cholesterol level. As characteristic findings of this study, lacunar infarction (LI), which is thought to represent cerebral arteriolosclerosis, was not only significantly correlated with age and hypertension, but increased also lacunar infarcts in number as the number of affected coronary branches increased. Examination of the cases of severe coronary artery disease with MRI/MRA was thought to be able to predict the occurrence of cerebrovascular disorder after CABG and to be useful for the selection of a therapeutic regimen, such as PTCA and MID-CABG. (author)

  6. MR angiography for follow-up after percutaneous vessel recanalization and surgery

    International Nuclear Information System (INIS)

    This paper compares MR angiography with conventional and digital subtraction angiography (DSA) in arteriosclerosis and to find out whether arteriosclerotic vessel pathology is delineated correctly by MR angiography. MR angiographic findings in 103 cases were correlated with DSA and conventional angiographic findings. The angiograms were obtained in patients with arteriosclerosis before and after percutaneous recanalization or vascular surgery in the femoropopliteal region. For MR angiography, a flow-sensitive, three-dimensional, fast imaging with steady precision sequence with rephased and dephased subtracted images were used on a 1.5-T Magnetom imager. The scan time is 4-5 minutes

  7. Efecto "in vivo" de los derivados fíbricos sobre enzimas microsomales implicados en la síntesis hepática de ácidos grasos

    OpenAIRE

    Alegret i Jordà, Marta

    1993-01-01

    La arteriosclerosis es una enfermedad de origen multifactorial, principal causa de deterioro en la calidad de vida o de mortalidad precoz en los países industrializados, debido a que desemboca con frecuencia en accidentes vasculares como el infarto agudo de miocardio. Entre los factores de riesgo cuya corrección puede conducir a la prevención del desarrollo de la arteriosclerosis destacan las hiperlipoproteinemias. Los fibratos son fármacos hipolipemiantes eficaces en el tratamiento de las hi...

  8. Pneumothorax in an early phase after allogeneic hematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Yasuhiro Ebihara

    2013-06-01

    Full Text Available Pneumothorax is very rare after early phase of hematopoietic stem cell transplantation (HSCT and usually accompanied with pulmonary chronic graft-versus-host disease (GVHD, such as bronchiolitis obliterans and bronchiolitis obliterans organizing pneumonia. The present study describes the case of a seventeen-year-old male diagnosed with acute myeloid leukemia who underwent allogeneic bone marrow transplantation (BMT. Pneumothorax occurred at day 43 after BMT. Pneumothorax occurred in early phase of HSCT is extremely rare. The early onset of acute GVHD and the entity of cytomegalovirus might worsen the pulmonary tissue damages for the onset of pneumothorax, indicating that we should be aware of the possibility to occur pneumothorax even in the early period after allogeneic HSCT.

  9. Raynaud's phenomenon in arterial obstructive disease of the hand demonstrated by locally provoked cooling

    DEFF Research Database (Denmark)

    Nielsen, Steen Levin; Nobin, B A; Hirai, M;

    1978-01-01

    Finger systolic blood pressure (FSP) was measured by cuff technique before and after local cooling in three groups of patients (Raynaud's disease (7), subclavian stenoses, (5), thrombo-angiitis obliterans (15)), and in 15 normals. The response to finger cooling registered as a decrease in FSP...... indicates an increase of digital arterial tone. In all three groups, digital arterial tone increased more than in normals during finger cooling. Patients with Raynaud's disease showed a pathological increase in arterial tone at 23.5 degrees C with closure of the digital arteries at a mean temperature of 18.......5 degrees C. The temperature eliciting these phenomena in patients with thrombo-angiitis obliterans was about 7 degrees C lower (16.5 and 11.0 degrees C, respectively). Accordingly, cold sensitivity and Raynaud's phenomena in the two groups may have a different pathophysiological mechanism, namely...

  10. Chlamydia in canine or feline coronary arteriosclerotic lesions

    Directory of Open Access Journals (Sweden)

    Grabarevic Zeljko

    2011-09-01

    Full Text Available Abstract Background There are numerous reports linking Chlamydia infection to human coronary atherosclerosis. However, there is a lack of data regarding this correlation in dogs and cats, and there are no reports investigating coronary arteriosclerosis and Chlamydia in these species. The aim of the present study was to examine whether there is a correlation between canine and feline spontaneous atherosclerosis or arteriosclerosis and the presence of Chlamydia. Archived histopathological samples of dogs (n = 16 and cats (n = 13 with findings of atherosclerosis or arteriosclerosis in heart tissue were examined for the presence of Chlamydiaceae using real-time PCR, ArrayTube Microarray and immunohistochemistry. Additionally, arteriosclerotic lesions of all cases were histologically classified and graded. Results Both canine atherosclerotic cases, and all 14 canine arteriosclerotic cases were negative for Chlamydia. Only one of the 13 arteriosclerotic feline cases was positive for Chlamydia by real-time PCR, revealing C. abortus by ArrayTube Microarray. To our knowledge, this is the first description of C. abortus in a cat. Overall, the type and grade of canine and feline arteriosclerotic lesions revealed similarities, and were predominantly moderate and hyperplastic. Conclusions These findings suggest that there is no obvious correlation between canine and feline coronary arteriosclerosis and the presence of Chlamydia. In order to draw final conclusions about the correlation between Chlamydia and canine atherosclerosis, examination of more samples is required.

  11. Relation of Serum Adiponectin Levels to Number of Traditional Atherosclerotic Risk Factors and All-Cause Mortality and Major Adverse Cardiovascular Events (from the Copenhagen City Heart Study)

    DEFF Research Database (Denmark)

    Lindberg, Soren; Mogelvang, Rasmus; Pedersen, Sune H;

    2013-01-01

    Adiponectin exerts anti-inflammatory and antiatherogenic effects and appears to protect against arteriosclerosis. Accordingly, an association between low concentrations of plasma adiponectin and cardiovascular (CV) disease has been demonstrated in several studies. In contrast, elevated plasma...... or nonfatal myocardial infarction or ischemic stroke (n = 502). High adiponectin was inversely associated with an increasing number of traditional CV risk factors (p...

  12. Relativity analysis of arterosclerotic cerebral infarction of senile patients and secondary epilepsy%老年动脉硬化性脑梗死与继发性癫痫相关性分析

    Institute of Scientific and Technical Information of China (English)

    张英杰; 马艳

    2001-01-01

    @@Background: Acute cerebral vascular secondary epilepsy isn't uncommon in clinic.It can happen at any time of epilepsy,even as first- onset or main clinical manifestation.Main cause of stroke of senile patients is arteriosclerosis,which is main cause of old stage epilepsy. Objective:To analyze relativity of arterosclerotic cerebral infarction of senile patients and secondary epilepsy.

  13. Water Flow through Xylem: An Investigation of a Fluid Dynamics Principle Applied to Plants

    Science.gov (United States)

    Rice, Stanley A.; McArthur, John

    2004-01-01

    A study was conducted to prove that a large blood or xylem vessel could conduct 256 times more fluid than a vessel or a pipe that is four times smaller. The result of this study proved that if arteriosclerosis causes an artery to loose half its effective diameter, the blood flow would be reduced by fifteen-sixteenths.

  14. Doppler-ultralydundersøgelse af underekstremitetsarteriosklerose

    DEFF Research Database (Denmark)

    Rørdam, P; von Jessen, F; Sillesen, H H;

    1992-01-01

    Arteriography, which requires resources and is not entirely without risk, has hitherto been a prerequisite for reconstructive surgery in cases of symptom-producing arteriosclerosis in the lower limbs. As an alternative, indirect Doppler ultrasonic examination has been employed but does not appear...

  15. The Benefits of Health Maintenance.

    Science.gov (United States)

    Rosenstein, Alan H.

    1987-01-01

    The article focuses on the merits of a comprehensive, medically-oriented health maintenance/risk assessment program, and suggests that such conditions as heart disease, cancer, and arteriosclerosis can be prevented or postponed through proper nutrition, weight control, exercise, smoking cessation, and stress management. (Author/CB)

  16. Preventing and Treating Type 2 Diabetes through a Physically Active Lifestyle

    Science.gov (United States)

    Leung, Raymond W.; Kamla, Jim; Lee, Man-Cheong; Mak, Jennifer Y.

    2007-01-01

    The general decrease in physical activity in the United States population has led to an increase of cases of type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), obesity, dyslipidemia, hypertension, and arteriosclerosis. Remarkable scientific advancements have been made toward understanding the beneficial effects of physical activity…

  17. Association of non-alcoholic fatty liver disease and coronary artery disease

    Directory of Open Access Journals (Sweden)

    Biswajit Majumder

    2016-10-01

    Conclusions: From our current study it can be reasonably said that NAFLD may be an independent risk factor for developing arteriosclerosis. This hypothesis should be verified with larger studies in different population groups. [Int J Res Med Sci 2016; 4(10.000: 4359-4364

  18. Is pancreatic polypeptide response to food ingestion a reliable index of vagal function in type 1 diabetes?

    DEFF Research Database (Denmark)

    Damholt, M B; Arlien-Soeborg, P; Hilsted, L;

    2006-01-01

    The diagnosis of autonomic neuropathy in diabetic patients is based on cardiovascular reflex tests. Since cardiac function may be affected by arteriosclerosis and cardiomyopathy in type 1 diabetes mellitus, alternative tests reflecting vagal nerve function, in other organ systems, are needed...

  19. Genetic and bibliographic information: MNDA [GenLibi

    Lifescience Database Archive (English)

    Full Text Available MNDA myeloid cell nuclear differentiation antigen human atherosclerosis (MeSH) Card...iovascular Diseases (C14) > Vascular Diseases (C14.907) > Arterial Occlusive Diseases (C14.907.137) > Arteriosclerosis... (C14.907.137.126) > Atherosclerosis (C14.907.137.126.307) 05A0467425 ...

  20. Relationship between coronary atherosclerosis and 'sudden cardiac death'

    International Nuclear Information System (INIS)

    Coronary arteriosclerosis in mini-pigs was produced by combination of hypercholesterolemia and twofold X irradiation of the cardiac region. 15-21 weeks following irradiation 40% of the adult animals and 58% of the juvenils died of 'sudden cardiac death'. The mortality rate decreased significantly after application of the calcium-channel blocking agent nifedipine

  1. Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

    DEFF Research Database (Denmark)

    Poulsen, Henrik E; Nadal, Laia Llovera; Broedbaek, Kasper;

    2014-01-01

    DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies...

  2. Non-Bone Marrow Origin of Neointimal Smooth Muscle Cells in Experimental In-Stent Restenosis in Rats

    NARCIS (Netherlands)

    Groenewegen, Hendrik C.; Onuta, Geanina; Goris, Maaike; Zandvoort, Andre; Zijlstra, Felix; van Gilst, Wiek H.; Rozing, Jan; de Smet, Bart J. G. L.; Roks, Anton J. M.; Hillebrands, Jan-Luuk

    2008-01-01

    Objective: To determine the contribution of bone marrow (BM)-derived cells in in-stent restenosis (ISR) and transplant arteriosclerosis (TA). Methods: Non-transgenic rats WT F344(TG) (n = 3) received stent implantation 6 weeks after lethal total body irradiation and suppletion with bone marrow from

  3. Quantitative Measurement of Changes in Retinal Vessel Diameter in Ocular Fundus Images

    DEFF Research Database (Denmark)

    Pedersen, Lars; Grunkin, Michael; Ersbøll, Bjarne Kjær;

    1999-01-01

    The Change in diameter of retinal vessels as a funcion of increasing distance to the optic disc is believed to be indicative of the risk level of various vascular diseases such as generalised arteriosclerosis and Diabetes Mellitus. In particular, Focal Arteriolar Narrowing (FAN) is considered...

  4. Environmental variation of arsenic levels in human blood determined by neutron activation analysis

    DEFF Research Database (Denmark)

    Heydorn, Kaj

    1970-01-01

    Arsenic levels in blood plasma and red cells from patients with Blackfoot disease, a peripheral arteriosclerosis endemic to a small area in Taiwan, were studied in relation to healthy individuals from the same and other parts of Taiwan and compared with arsenic levels in a control group from Denm...

  5. Ischemic pain in the extremities and Raynaud's phenomenon.

    NARCIS (Netherlands)

    Devulder, J.; Suijlekom, H. van; Dongen, R.T.M. van; Diwan, S.; Mekhail, N.; Kleef, M. van; Huygen, F.

    2011-01-01

    Two important groups of disorders result from an insufficient blood supply to the extremities: critical vascular disease and the Raynaud's phenomenon. The latter can be subdivided into a primary and a secondary type. Critical ischemic disease is often caused by arteriosclerosis due to hypertension o

  6. Constrictive pericarditis after lung transplantation: an under-recognized complication.

    Science.gov (United States)

    Karolak, Wojtek; Cypel, Marcelo; Chen, Fengshi; Daniel, Lorretta; Chaparro, Cecilia; Keshavjee, Shaf

    2010-05-01

    Primary graft dysfunction, acute rejection, and infection account for most of the early morbidity after lung transplantation, with bronchiolitis obliterans syndrome accounting for most late morbidity. Mediastinal and pericardial complications, in the form of constriction, are not common. We present 4 patients with constrictive pericarditis after lung transplantation and recommend that constrictive pericarditis be considered in the differential diagnosis in lung transplant recipients who present with signs and symptoms of systemic and pulmonary venous congestion. PMID:20207169

  7. Noninvasive Investigations for the Early Detection of Chronic Airways Dysfunction Following Lung Transplantation

    OpenAIRE

    Cook, Richard C.; Guy Fradet; Nestor L Muller; Daniel F Worsley; David Ostrow; Levy, Robert D

    2003-01-01

    BACKGROUND: The diagnosis of chronic rejection after lung transplantation is limited by the lack of a reliable test to detect airways disease early.OBJECTIVES: To determine whether maximum midexpiratory flow (MMEF), or changes on high resolution computed tomography (HRCT) or ventilation/perfusion lung (V/Q) scans are sensitive and specific for early detection of bronchiolitis obliterans syndrome (BOS; forced expiratory volume in 1 s [FEV1] less than 80% post-transplant baseline) by evaluating...

  8. 小儿闭塞性细支气管炎1例报道

    Institute of Scientific and Technical Information of China (English)

    房中华; 王雪峰

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,在儿童中是一种相对少见而严重的慢性阻塞性肺病。我院采用中西医结合疗法治愈BO1例,报道如下。

  9. Acute chemical pneumonitis caused by nitric acid inhalation: case report

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Hyung Shim; Lee, In Jae; Ko, Eun Young; Lee, Jae Young; Kim, Hyun Beom; Hwang, Dae Hyun; Lee, Kwan Seop; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2003-06-01

    Chemical pneumonitis induced by nitric acid inhalation is a rare clinical condition. The previously reported radiologic findings of this disease include acute permeability pulmonary edema, delayed bronchiolitis obliterans, and bronchiectasis. In very few published rare radiologic reports has this disease manifested as acute alveolar injury; we report a case of acute chemical pneumonitis induced by nitric acid inhalation which at radiography manifested as bilateral perihilar consolidation and ground-glass attenuation, suggesting acute alveolar injury.

  10. Regional ventilation/perfusion mismatch pattern in patient with Swyer James (MacLeod's) syndrome

    OpenAIRE

    Sait Sager; Sertac Asa; Reşit Akyel; Ersan Atahan; Bedii Kanmaz

    2014-01-01

    Swyer James (McLeod′s) syndrome (SJMS) is an uncommon disease, which occurs as a result of childhood bronchiolitis obliterans. Patients may not be diagnosed until later in their life. A 46-year-old man underwent ventilation/perfusion scintigraphy for acute onset of dyspnea. The scan showed markedly diminished ventilation and perfusion unilaterally on the right middle and inferior lobes. However, mismatched ventilation-perfusion pattern was shown on the upper right lobe, which was consistent w...

  11. Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

    Directory of Open Access Journals (Sweden)

    Annie M Bérard

    Full Text Available BACKGROUND: This study aimed to determine the prevalence of genetic and environmental vascular risk factors in non diabetic patients with premature peripheral arterial disease, either peripheral arterial occlusive disease or thromboangiitis obliterans, the two main entities of peripheral arterial disease, and to established whether some of them are specifically associated with one or another of the premature peripheral arterial disease subgroups. METHODS AND RESULTS: This study included 113 non diabetic patients with premature peripheral arterial disease (diagnosis <45-year old presenting either a peripheral arterial occlusive disease (N = 64 or a thromboangiitis obliterans (N = 49, and 241 controls matched for age and gender. Both patient groups demonstrated common traits including cigarette smoking, low physical activity, decreased levels of HDL-cholesterol, apolipoprotein A-I, pyridoxal 5'-phosphate (active form of B6 vitamin and zinc. Premature peripheral arterial occlusive disease was characterized by the presence of a family history of peripheral arterial and carotid artery diseases (OR 2.3 and 5.8 respectively, 95% CI, high lipoprotein (a levels above 300 mg/L (OR 2.3, 95% CI, the presence of the factor V Leiden (OR 5.1, 95% CI and the glycoprotein Ia(807T,837T,873A allele (OR 2.3, 95% CI. In thromboangiitis obliterans group, more patients were regular consumers of cannabis (OR 3.5, 95% CI and higher levels in plasma copper has been shown (OR 6.5, 95% CI. CONCLUSIONS: According to our results from a non exhaustive list of study parameters, we might hypothesize for 1 a genetic basis for premature peripheral arterial occlusive disease development and 2 the prevalence of environmental factors in the development of thromboangiitis obliterans (tobacco and cannabis. Moreover, for the first time, we demonstrated that the 807T/837T/873A allele of platelet glycoprotein Ia may confer an additional risk for development of peripheral

  12. Massive Hematochezia: A Complication of Methamphetamine-Induced Vasculitis Treated by Transcatheter Hemostasis

    Directory of Open Access Journals (Sweden)

    Daniel P. Link

    2011-01-01

    Full Text Available A long-term, heavy methamphetamine user with life-threatening rectal hemorrhage was treated with transcatheter occlusion of the bleeding arteries. The bleeding blood vessels were vulnerable submucosal arteries, part of the collateral supply to the distal colon. Visceral arteriography demonstrates severe arterial stenotic lesions of the celiac axis, superior mesenteric artery and the inferior mesenteric artery. Collateral vessels were seen with corkscrew morphology similar to that seen with thromboangiitis obliterans.

  13. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard

    OpenAIRE

    Majid Ebrahimi; Mehryar Habibi Roudkenar; Abbas Ali Imani Fooladi; Raheleh Halabian; Mostafa Ghanei; Hisatake Kondo; Mohammad Reza Nourani

    2010-01-01

    Sulfur mustard (SM) is a potent vesicant that has been employed as a chemical weapon in various conflicts during the 20th century. More recently, mustard was used in the Iraq conflict against Iranian troops and civilians. At the present time there are more than 40.000 people suffering from pulmonary lesions special bronchiolitis obliterans (BOs) due to mustard gas. SM increases the endogenous production of reactive oxygen species (ROS). Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL...

  14. Application of a four-channel vibrometer system for detection of arterial stiffness

    Science.gov (United States)

    Campo, Adriaan; Waz, Adam; Dudzik, Grzegorz; Dirckx, Joris; Abramski, Krzysztof

    2016-06-01

    Cardiovascular diseases (CD) are the most important cause of death in the world and their prevalence is only rising. A significant aspect in the etiology of CD is the stiffening of the large arteries (arteriosclerosis) and plaque formation (atherosclerosis) in the common carotid artery (CCA) in the neck. As shown by increasing evidence, both conditions can be detected by assessing pulse wave velocity (PWV) in the CCA, and several approaches allow local detection of PWV, including ultrasound (US) and magnetic resonance imaging (MRI). In previous studies, laser Doppler vibrometry (LDV) was introduced as an approach to assess arterial stiffness. In the present work, a new, compact four-channel LDV system is used for PWV detection in four phantom arteries mimicking real life CCA conditions. The high sensitivity of the LDV system allowed PWV to be assessed, and even local changes in phantom architecture could be detected. This method has potential for cardiovascular screening, as it allows arteriosclerosis assessment and plaque detection.

  15. Border detection on Common Carotid Artery using Gauss-Markov Estimation

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility, high accuracy and high-speed. In this paper, we propose the high-accuracy and high-speed detection method by Gauss-Markov estimation. About high-accuracy, it realized by attaching importance to high reliable candidate point of border. And, about high-speed, it realized by calculating matrix only one time.

  16. Border Detection of Common Carotid Artery Using Hough Transform

    Science.gov (United States)

    Koya, Yoshiharu; Nagahara, Yoshihiro

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. The arteriosclerosis of the common carotid artery is diagnosed using Intima-Media Thickness (IMT) which is obtained from echocardiogram. In order to measure IMT from echocardiogram, it is required to detect a border which is a boundary between vessel tissue layers. The method of border detection requires reproducibility and high accuracy. The conventional methods to detect the border curve depend on differential value of brightness on the common carotid artery. Therefore, we can't extract a good candidate point by influence of a noise. In this paper, we propose the high-accuracy detection method by Hough Transform. About high-accuracy, it realized by attaching importance to high reliable candidate point of border.

  17. A new course in the clinical pathways for metabolic syndrome

    International Nuclear Information System (INIS)

    Metabolic syndrome is consisted with multiple risk factors such as diabetes, dyslipidemia, and hypertension based on visceral fat accumulation, for the development of arteriosclerosis. We present, here, a clinical pathway for education of patients with metabolic syndrome. The program contains an adequate explanation of the high risk for arteriosclerosis to the patients, the measurement of visceral fat content by computed tomography, and several clinical examinations for the evaluation of arteriosclerotic lesions. We have presented this program on the ward of diabetes center in our hospital for patients diagnosed as having metabolic syndrome. Because the focus of education is to clarify understanding of the harmful effects of visceral fat and the benefits of its reduction, it might be a valuable tool to motivate and empower the patient and improve the patient's lifestyle. (author)

  18. Transgenetic Animal Model in Studying Blood Fat Metabolism%血脂类代谢研究中的转基因动物模型

    Institute of Scientific and Technical Information of China (English)

    卢笑丛; 王有为

    2003-01-01

    Transgenic animal model for diseases established to show diversified disease through the expression or excessiveexpression of gene. The lipid metabolizing is very a complex physiological process in human. During the gene-relating lipid metabolizing, it includes the factors of causing arteriosclerosis formed and the factors of reducing arteriosclerosis attack. This paper described the transgenic animal model and its characters of gene of aplipoprotein (Apo) such as ApoE,ApoA, ApoB, ApoC, receptor gene sweeping receptor SR-A, SR-B and SR-CD, gene of lipid metabolizing enzyme,gene of transprotein such as CETP, LPL etc. Those transgenic animal models play an important role in studying disease mechanism, drug screening, gene treatment and in producing the protein as drug using.

  19. Nutritional phenolic compounds in red wines determined by HPLC-DAD-ESI-MS and MS/MS technique

    OpenAIRE

    Ivanova, Violeta; Hermosín-Gutiérrez, Isidro; Vojnoski, Borimir; Gulaboski, Rubin

    2015-01-01

    Red wine is a rich source of bioactive and nutritional phenolic compounds which show antioxidant properties, present potential health effect, exhibit a free radical scavenging activity as well as a protective activity against arteriosclerosis, coronary heart disease or inhibit the cancer cell growth. In this study, the detailed phenolic profile of Macedonian red wines Vranec, Merlot and Cabernet Sauvignon, was determined. For that purpose, a high-performance liquid chromatography coupled with...

  20. Risk Factors for Central and Branch Retinal Vein Occlusion: A Meta-Analysis of Published Clinical Data

    OpenAIRE

    Kolar, Petr

    2014-01-01

    Retinal vein occlusion (RVO) is a major cause of vision loss. Of the two main types of RVO, branch retinal vein occlusion (BRVO) is 4 to 6 times more prevalent than central retinal vein occlusion (CRVO). A basic risk factor for RVO is advancing age. Further risk factors include systemic conditions like hypertension, arteriosclerosis, diabetes mellitus, hyperlipidemia, vascular cerebral stroke, blood hyperviscosity, and thrombophilia. A strong risk factor for RVO is the metabolic syndrome (hyp...

  1. Calcificación vascular asociada a inflamación : influencia de la vitamina D

    OpenAIRE

    Guerrero Pavón, Fátima

    2012-01-01

    Arteriosclerosis y aterosclerosis son procesos comunes en los pacientes con enfermedad renal crónica (ERC). De hecho, la calcificación vascular (CV) representa un importante factor de riesgo que contribuye a la alta tasa de mortalidad cardiovascular asociada a la ERC. En pacientes urémicos, la CV está causada, en parte, por alteraciones en el metabolismo mineral estrechamente relacionadas con el control del hiperparatiroidismo secundario (HPT2º). Los pacientes con ERC muestr...

  2. Bypassmaterialien in der Gefäßchirurgie

    OpenAIRE

    Eidt, D; Roll, S.; Kulp, W; Müller-Nordhorn, J.; Vauth, C; Greiner, W; Willich, SN; von der Schulenburg, JM

    2006-01-01

    Introduction Arteriosclerotic changes can lead to circulatory disturbances in various areas of the human vascular system. In addition to pharmacological therapy and the management of risk factors (e. g. hypertension, diabetes, lipid metabolism disorders, and lifestyle), surgical interventions also play an important role in the treatment of arteriosclerosis. Long-segment arterial occlusions, in particular, can be treated successfully with bypass sur-gery. A number of different materials are av...

  3. Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus

    OpenAIRE

    ,; Seino, Yutaka; Nanjo, Kishio; Tajima, Naoko; Kadowaki, Takashi; Kashiwagi, Atsunori; Araki, Eiichi; Ito, Chikako; Inagaki, Nobuya; Iwamoto, Yasuhiko; Kasuga, Masato; Hanafusa, Toshiaki; Haneda, Masakazu; Ueki, Kohjiro

    2010-01-01

    Abstract Concept of Diabetes Mellitus: Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long‐term persistence of metabolic disorders can cause susceptibility to specific complications and also foster arteriosclerosis. Diabetes mellitus is associated with a broad range of clinical presentations, from be...

  4. Clinical Observation on Acupuncture Treatment of Cerebrovascular Dementia- A Report of 32 Cases

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Cerebrovascular dementia is a common disease in the middle-aged and old people. Its incidence makes up about 10-20% of all kinds of dementia. It is mainly caused by general degeneration of the brain function resulted from cerebral arteriosclerosis and cerebral infarction. The author has treated 32 cases of cerebrovascular dementia with acupuncture in the recent years with satisfactory therapeutic results. A report follows.

  5. Medial arterial calcification, calcific aortic stenosis and mitral annular calcification in a diabetic patient with severe autonomic neuropathy.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Medial arterial calcification (Monckeberg\\'s arteriosclerosis) is well described in diabetic patients with autonomic neuropathy. There is also a high prevalence of diabetes mellitus among subjects with calcific aortic stenosis and mitral annular calcification. We describe a diabetic patient with autonomic neuropathy and extensive medial arterial calcification who also had calcification of the aortic valve and of the mitral valve annulus. We propose that autonomic neuropathy may play a role in calcification of these structures at the base of the heart.

  6. Puncture-ejection of own egg by Least Bell's Vireo and potential implications for anti-parasitism defense

    Science.gov (United States)

    Sharp, Bryan L.; Peterson, Bonnie L.; Kus, Barbara E.

    2005-01-01

    A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia.

  7. Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret

    Science.gov (United States)

    Carpenter, J.W.; Davidson, J.P.; Novilla, M.N.; Huang, J.C.M.

    1980-01-01

    A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia.

  8. Correlation Factor Analysis of Retinal Microvascular Changes in Patients With Essential Hypertension

    Institute of Scientific and Technical Information of China (English)

    Huang Duru; Huang Zhongning

    2006-01-01

    Objectives To investigate correlation between retinal microvascular signs and essential hypertension classification. Methods The retinal microvascular signs in patients with essential hypertension were assessed with the indirect biomicroscopy lens, the direct and the indirect ophthalmoscopes were used to determine the hypertensive retinopathy grades and retinal arteriosclerosis grades.The rank correlation analysis was used to analysis the correlation these grades with the risk factors concerned with hypertension. Results Of 72 cases with essential hypertension, 28 cases complicated with coronary disease, 20 cases diabetes, 41 cases stroke,17 cases renal malfunction. Varying extent retinal arterioscleroses were found in 71 cases, 1 case with retinal hemorrhage, 2 cases with retina edema, 4 cases with retinal hard exudation, 5 cases with retinal hemorrhage complicated by hard exudation, 2 cases with retinal hemorrhage complicated by hard exudation and cotton wool spot, 1 case with retinal hemorrhage complicated by hard exudation and microaneurysms,1 case with retinal edema and hard exudation, 1 case with retinal microaneurysms, 1 case with branch retinal vein occlusion. The rank correlation analysis showed that either hypertensive retinopathy grades or retinal arteriosclerosis grades were correlated with risk factor lamination of hypertension (r=0.25 or 0.31, P<0.05), other correlation factors included age and blood high density lipoprotein concerned about hypertensive retinopathy grades or retinal arteriosclerosis grades, but other parameters, namely systolic or diastolic pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose,blood urea nitrogen and blood creatinine were not confirmed in this correlation analysis (P > 0.05).Conclusions Either hypertensive retinopathy grade or retinal arteriosclerosis grade is close with the hypertension risk factor lamination, suggesting that the fundus examination of patients with

  9. C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes

    OpenAIRE

    Beom Seob Lee; Soo Hyuk Kim; Jaewon Oh; Taewon Jin; Eun Young Choi; Sungha Park; Sang-Hak Lee; Ji Hyung Chung; Seok-Min Kang

    2014-01-01

    C-reactive protein (CRP) is one of the most important biomarkers for arteriosclerosis and cardiovascular disease. Recent studies have shown that CRP affects cell cycle and inflammatory process in cardiac myocytes. Survivin is also involved in cardiac myocytes replication and apoptosis. Reduction of survivin expression is associated with less favorable cardiac remodeling in animal models. However, the effect of CRP on survivin expression and its cellular mechanism has not yet been studied. We ...

  10. The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies

    OpenAIRE

    Davies, Melanie

    2016-01-01

    Melanie Davies,1,2 Sudesna Chatterjee,1,2 Kamlesh Khunti1,2 1Diabetes Research Centre, University of Leicester, 2Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK Abstract: Worldwide, an estimated 200 million people have chronic kidney disease (CKD), the most common causes of which include hypertension, arteriosclerosis, and diabetes. Importantly, ~40% of patients with diabetes develop CKD, yet evidence from major multicenter randomized controlled trials s...

  11. Arterial Stiffening and Clinical Outcomes in Dialysis Patients

    OpenAIRE

    Kato, Akihiko

    2015-01-01

    Cardiovascular disease (CVD) is an important cause of morbidity and mortality in dialysis patients. Brachial-ankle pulse wave velocity (baPWV) is more efficient to handily assess arteriosclerosis than aortic PWV. The cardio-ankle vascular index (CAVI) is also a novel blood pressure-independent arterial stiffness parameter. In dialysis patients, both baPWV and CAVI are increased compared to general subjects. Several studies have demonstrated that increased baPWV is associated with carotid athe...

  12. Effect of Lactic Acid Bacteria on Lipid Metabolism and Fat Synthesis in Mice Fed a High-fat Diet

    OpenAIRE

    YONEJIMA, Yasunori; Ushida, Kazunari; Mori, Yoshiro

    2013-01-01

    Visceral fat accumulation is a major risk factor for the development of obesity-related diseases, including diabetes, hyperlipidemia, hypertension, and arteriosclerosis. Stimulation of lipolytic activity in adipose tissue or inhibition of fat synthesis is one way to prevent these serious diseases. Lactic acid bacteria have an anti-obesity effect, but the mechanisms are unclear. Therefore, we evaluated the effect of the administration of lactic acid bacteria (Lactobacillus gasseri NT) on lipid...

  13. Not at random location of atherosclerotic lesions in thoracic aorta and their prognostic significance in relation to the risk of cardiovascular events

    International Nuclear Information System (INIS)

    Thoracic aortic calcium deposits are frequently detected on tomography of the chest, and in other imaging modalities. Numerous studies indicated the correlation of hemodynamic parameters such as wall shear stress in relation to distribution aortic calcifications. This publication discusses similarities and differences of two distinct pathomechanisms of arterial calcifications: intimal associated with atherosclerosis and medial knows as Mönckeberg’s arteriosclerosis. This review also analyzes the frequent coexistence of aortic calcification and coronary artery disease in terms of risk of cardiovascular events

  14. Blood pressure changes resulting from aortography.

    OpenAIRE

    Snowdon, S L; Whitehouse, G. H.

    1981-01-01

    Patients requiring aortography frequently suffer from generalized arteriosclerosis. Uncontrolled hypotension is therefore clearly undesirable, especially if associated with myocardial depression. Significant hypotension was observed following the use of conventional ionic contrast media, Urografin 370 and Cardioconray, and occurred following every injection in this study. Metrizamide, a non-ionic contrast medium, was found to be associated with a smaller fall in blood pressure of a shorter du...

  15. Homocysteine and atheromatosis

    Institute of Scientific and Technical Information of China (English)

    洪梅

    2006-01-01

    @@ Homocysteine (Hcy) was first linked with atherosclerosis over more than 30 years ago. McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma Hcy concentrations and homocystinuria in 1969. On the basis of this clinical observation, he put forward the Hcy theory of arteriosclerosis. Subsequent investigations HHcy have confirmed the association between and premature atherosclerosis of the coronary, cerebrovascular, and peripheral vascular beds.

  16. Obsah vybraných fenolických látek v kořeninových rostlinách.

    OpenAIRE

    BERANOVÁ, Zuzana

    2013-01-01

    This work concerns the amount of certain phenols in some of the representatives of families Alliaceae, Lamiaceae and Apiaceae. Phenols in plants are widely represented and highly concentrated. Flavonoids are one of the smallest, yet quite significant classes of phenols. Ingestion of food containing flavonoids can prevent certain diseases such as Arteriosclerosis. cardiovascular and tumor diseases. This work focuses, for their special biological effects, on five flavonoids: Kaempferol, Quercet...

  17. Relationship between vascular endothelial function and pulse wave velocity in prehypertension

    Institute of Scientific and Technical Information of China (English)

    杨娉婷

    2014-01-01

    Objective To investigate the association between vascular endothelial function and arteriosclerosis in prehypertensive,hypertensive and healthy subjects.Methods 810 consecutive subjects were divided into three groups:hypertension group,prehypertension group and control group.Brachial-ankle pulse wave velocity(ba PWV)and flow-mediated brachial artery dilation(FMD)were used to evaluate the artery vascular stiffness and endothelial function respectively.Results Prehypertension

  18. Chronic cardiac rejection: identification of five upregulated genes in transplanted hearts by differential mRNA display.

    OpenAIRE

    Utans, U; Liang, P; Wyner, L R; Karnovsky, M. J.; Russell, M. E.

    1994-01-01

    Transplant arteriosclerosis, the major manifestation of chronic rejection, develops after allogeneic (Lewis to F344) but not syngeneic (Lewis to Lewis) rat cardiac transplantation. To identify transcriptionally regulated mediators associated with chronic cardiac rejection, we adapted the differential mRNA display technique for in vivo transplant specimens. Gene transcript patterns in four allogeneic hearts showing early signs of chronic rejection were compared with those in two syngeneic hear...

  19. ストレス課題における心臓血管系反応に対する怒り表出性の検討 : anger expression-inの効果

    OpenAIRE

    石原, 俊一

    2006-01-01

    Recently, it has been suggested that anger expressions such as anger-in, anger-out, and anger-control contribute to the development of coronary heart disease (CHD). In the 1980s, an increased number of studies indicated that anger and hostility were directly related to CHD. Dembroski et al. reported the relationship between angiographically documented coronary arteriosclerosis and anger and hostility. Williams et al. found a relationship between the scale of hostility in the Minnesota Multiph...

  20. Searching of the peripheric arterial disease in which patient have cerebrovascular event

    OpenAIRE

    Kanar, Rayiha Görkem

    2012-01-01

    Arteriosclerotic disease a systemic disease. Arteriosclerotic disease may affect more than one region in vascular system. In the presence of risk factors of arteriosclerosis; clinical manifestations will emerge depending on organ involvement. The aim of our study is searching the association of peripheral artery disease and determining related risk factors in patients who had cerebrovascular event. This study was performed by Cardiovascular Surgery Department of Trakya Universty Faculty of Me...

  1. KLOTHO Allele Status and the Risk of Early-Onset Occult Coronary Artery Disease

    OpenAIRE

    Arking, Dan E; Becker, Diane M.; Lisa R Yanek; Fallin, Daniele; Judge, Daniel P.; Moy, Taryn F.; Becker, Lewis C.; Dietz, Harry C.

    2003-01-01

    We previously identified a functional variant of KLOTHO (termed “KL-VS”), which harbors two amino acid substitutions in complete linkage disequilibrium and is associated with reduced human longevity when in homozygosity. Klotho-deficient mice display extensive arteriosclerosis when fed a normal diet, suggesting a potent genetic predisposition. To determine whether klotho influences atherosclerotic risk in humans, we performed cross-sectional studies to assess the association between the KL-VS...

  2. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

    OpenAIRE

    Fujimoto Kei; Nishioka Makiko; Miyashita Yumi; Hiki Yoshito; Sasaki Takashi; Nishimura Rimei; Nemoto Masami; Sakuma Toru; Ohashi Toya; Fukuda Kunihiko; Eto Yoshikatsu; Tajima Naoko

    2007-01-01

    Abstract Background Although oxidative stress by accumulation of reactive oxygen species (ROS) in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for development of atherosclerosis in diabetes. This study evaluated the effect of genetic polymorphism of enzymes producing or responsible for reducing ROS on coronary artery calcification in type 2 diabetes (T2D). Methods An index for coronary-arteriosclerosis, coronary artery c...

  3. 关于小儿闭塞性细支气管炎的再认识

    Institute of Scientific and Technical Information of China (English)

    张永菊; 张会武; 孟秋云; 刘金霞; 赵玉岐

    2016-01-01

    Pediatricbronchiolitis obliterans is one of the severe chronic lung diseases in children. Also it is the common prognosis for all kinds of pathogeny resulting in lung damage. Because of the low rate of incidence and terrible prognosis, lots of clinician can not recognize it in the early time. In recent years, the rate of bronchiolitis obliterans has increased obviously, which has brought attention among pediatric clinicians. But this disease can not be recognized early because of the lack of specificity. Especially the grassroots pediatric clinicians may misdiagnose because of lacking experience of this disease. In order to increase awareness of pediatric bronchiolitis obliterans, we will explain it in the following aspects: occurrence, development, the causes, thediagnosisandtreatment, and prognosis.%闭塞性细支气管炎是小儿时期较严重的慢性肺部疾病之一,是各种病因导致肺损伤的共同转归。在早期因发病率低,预后差,导致不被临床医师所认识。近几年来该病发病率有明显上升趋势,这已经引起了儿科临床医师的重视。但是该病因临床缺乏特异性表现,不易被早期认识。尤其在基层的儿科医师因缺乏对该病的临床经验,易导致误诊误治。为提高基层儿科医师对该病的再认识。现从闭塞性细支气管炎的发生、发展、病因、诊治及预后等几个方面进行综述。

  4. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    International Nuclear Information System (INIS)

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  5. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  6. Elective preterm delivery as a management option in cryptogenic organizing pneumonia.

    Science.gov (United States)

    Holder, Kelly L; Scardo, James A; Laye, M Ryan

    2011-06-01

    Bronchiolitis obliterans organizing pneumonia, now termed as cryptogenic organizing pneumonia (COP), is a fibrotic lung disease of the small airways with the potential to progress to end-stage lung disease. COP in pregnancy carries a high risk of maternal and neonatal complications and only two prior cases have been reported. This is the first case of pre-existing COP in pregnancy. We report a 16-year-old primigravid with COP who elected inpatient management and preterm delivery as a successful management option.

  7. [Short- and long-term complications of arterial reconstructions in gerontological patients].

    Science.gov (United States)

    Ismailov, N B; Vesnin, A V

    2008-01-01

    The present work deals with analysing complications and causes of their development in the immediate and remote (5-year) period of dispensary follow-up after reconstructive arterial operations interventions in patients aged 70 years old and over, suffering from atherosclerosis obliterans of the lower-limb arteries. Based on considerable clinical material, the authors consider the main vascular, non-vascular and systemic complications, their incidence rate and character, depending upon the type of revascularization of the extremity involved. Also formulated herein are the conclusions on profitability and rationale of a particular surgical policy in treatment for chronic ischaemia of the lower limbs in elderly and aged patients. PMID:19156041

  8. Regional ventilation/perfusion mismatch pattern in patient with Swyer James (MacLeod's) syndrome.

    Science.gov (United States)

    Sager, Sait; Asa, Sertac; Akyel, Reşit; Atahan, Ersan; Kanmaz, Bedii

    2014-09-01

    Swyer James (McLeod's) syndrome (SJMS) is an uncommon disease, which occurs as a result of childhood bronchiolitis obliterans. Patients may not be diagnosed until later in their life. A 46-year-old man underwent ventilation/perfusion scintigraphy for acute onset of dyspnea. The scan showed markedly diminished ventilation and perfusion unilaterally on the right middle and inferior lobes. However, mismatched ventilation-perfusion pattern was shown on the upper right lobe, which was consistent with pulmonary embolism. Unilaterally matched ventilation/perfusion defect can see in SJMS in lung scintigraphy; however, when pulmoner embolism may accompany, scintigraphy should be carefully examined. PMID:25535507

  9. 儿童闭塞性细支气管炎二例并文献复习

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 赵津生

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是儿科临床少见的以进行性呼吸困难及气流受阻为特点的慢性阻塞性疾病.自1901年Lange首次报道至今,关于其发病机制、治疗及预后等仍未明确.现将我院近年诊断的2例患儿报道如下.

  10. 慢性移植物抗宿主病的诊断和临床分级指南

    Institute of Scientific and Technical Information of China (English)

    李娅娜

    2006-01-01

    @@ 慢性移植物抗宿主病(graft-versus-host disease,GVHD)是异基因造血干细胞移植(hematopoietic cell transplantation,HCT)的主要并发症.其特征类似于自体免疫及其它免疫疾病的症状,如:硬皮病,S-综合征,原发胆汁性肝硬化,消耗病,闭塞性细支气管炎(bronchiolitis obliterans,BO),免疫性血细胞减少症,慢性免疫缺陷症.

  11. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher Malcolm; Carlsen, Jørn;

    2010-01-01

    SUMMARY: Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass...... slides, and used these antigen microarrays to profile 48 human serum samples for immunoglobulin G (IgG) and IgM autoantibodies; 27 patients showed no or mild bronchiolitis obliterans syndrome (BOS; a clinical correlate of OB) and 15 patients showed medium to severe BOS. We now report that these BOS...

  12. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher M.; Carlsen, Jørn;

    2010-01-01

    Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass slides......, and used these antigen microarrays to profile 48 human serum samples for immunoglobulin G (IgG) and IgM autoantibodies; 27 patients showed no or mild bronchiolitis obliterans syndrome (BOS; a clinical correlate of OB) and 15 patients showed medium to severe BOS. We now report that these BOS grades could...

  13. Politics, culture, and the legitimacy of disease: the case of Buerger's disease.

    Science.gov (United States)

    Lockwood, Stephen J; Bresler, Scott C; Granter, Scott R

    2016-09-01

    Thromboangiitis obliterans (TAO) or Buerger's disease is a rare form of vasculitis with distinctive clinical and pathological features that carries significant morbidity, often leading to amputation, and is strongly associated with tobacco smoking. Despite its distinctive clinicopathological characteristics, the existence of TAO as an entity sui generis was challenged for many years as it languished in relative obscurity. Then, as societal attitudes towards smoking changed, TAO not only became accepted as a disease entity, it quite literally became a poster child to illustrate the ills of smoking. Herein, we examine the history of TAO to illustrate the power of societal attitudes and politics in shaping medicine. PMID:27188859

  14. Aortic thrombosis in a patient with a late diagnosis of Behcet's disease

    Directory of Open Access Journals (Sweden)

    Ana Bittencourt Detanico

    2015-06-01

    Full Text Available Behcet's disease is form of systemic vasculitis of unknown etiology. One surprising feature is that arterial involvement is less common in this disease than venous forms, accounting for 1 to 7% of patients. In 7 to 30% of cases the vascular symptoms precede the clinical diagnosis of Behcet. We describe the case of a patient with Thromboangiitis Obliterans who was treated with lumbar sympathectomy and an aortobiiliac bypass. Around 1 year later he was diagnosed with Behcet's disease after presenting with oral ulcers, genital ulcers and scaling lesions on the hands.

  15. A case of BOOP-like pneumonia induced by radiotherapy after surgical resection of breast cancer which healed spontaneously

    International Nuclear Information System (INIS)

    The patient was a 67-year-old woman. After mastectomy, she received 50 Gy radiation to her chest wall using a tangential beam. About 3 months later, she developed dry cough, and an infiltrated shadow was noted in the irradiated lung. The shadow later moved to the opposite lung. The pneumonia healed spontaneously thereafter. This case is noteworthy since it endorses the previously reported clinical feature of broncholitis obliterans organizing pneumonia (BOOP), i.e., a high likelihood of spontaneous healing even when it is induced by radiotherapy. (author)

  16. Downregulation of super oxide dismutase level in protein might be due to sulfur mustard induced toxicity in lung.

    OpenAIRE

    Leila Mirbagheri; Mehryar Habibi Roudkenar; Abbas Ali Imani Fooladi; Mostafa Ghanei; Mohammad Reza Nourani

    2013-01-01

    Sulfur mustard (SM) has been identified as an important chemical weapon. During the Iran-Iraq war of 1980-88, the extensive usage of SM against Iranian civilians and military forces was proven. This agent has been shown to cause severe damage mainly in the skin, eyes, lungs,  and  respiratory  tract  in  Iranian  veterans.  The  most  common  disease  is bronchiolitis obliterans (BO)). SM increases the endogenous production of reactive oxygen species (ROS). Superoxide dismutases (SODs) are kn...

  17. Addition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness

    Directory of Open Access Journals (Sweden)

    Kiuchi S

    2015-10-01

    Full Text Available Shunsuke Kiuchi,1 Shinji Hisatake,1 Muneyasu Kawasaki,2 Osamu Hirashima,2 Takayuki Kabuki,1 Junichi Yamazaki,1 Takanori Ikeda1 1Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, 2Division of Cardiology and Cardiovascular Surgery, Misato Central General Hospital, Saitama, JapanBackground: The aim of controlling hypertension is to protect against arteriosclerosis. Calcium channel blockers (CCBs and renin-angiotensin-aldosterone system (RAAS inhibitors have been reported to have antihypertensive effects, but their effect on the progression of arteriosclerosis is not fully understood. The cardio-ankle vascular index (CAVI was developed to estimate arterial stiffness, which reflects arteriosclerosis. In this study, we investigated the longer term effects of CCBs and RAAS inhibitors on the progression of arteriosclerosis by monitoring the CAVI.Methods: Our subjects were 115 consecutive, non-smoking hypertensive patients on oral treatment with a CCB and/or RAAS inhibitor for at least 3 years in whom the CAVI was measured on two occasions approximately 1 year apart during the period from January 2009 to December 2011. Changes in CAVI were evaluated in patients administered a CCB alone (group C, an RAAS inhibitor (group R alone, or both drugs together (group B. Changes in laboratory findings, blood pressure, and ankle-brachial index were similarly evaluated.Results: No significant change in laboratory findings, blood pressure, or ankle-brachial index was noted in any of the groups. The CAVI decreased slightly in group R (first recording 8.80±1.03, second recording 8.57±0.97, P=0.517 and increased significantly in group C (first 8.45±0.92, second 8.95±1.04, P=0.038, but showed no significant change in group B (first 9.01±1.26, second 9.05±1.35, P=0.851.Conclusion: Long-term administration of a CCB alone increased the CAVI, but this effect was offset by the concomitant use of a RAAS inhibitor, indicating that a RAAS

  18. Mixed Herbal Medicine Induced Diffuse Infiltrative Lung Disease: The HRCT and Histopathologic Findings

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the high-resolution CT (HRCT) and pathologic findings of mixed herbal medicine-induced diffuse interstitial lung disease. Eight patients (6 women and 2 men, age range: 31 to 81 years, mean age: 51.4 years) who presented with cough or dyspnea after taking mixed herbal medicine were included in this study. All the patients underwent plain chest radiography and HRCT. We obtained pathologic specimens from 7 patients via fluoroscopy guided large bore cutting needle biopsy and transbronchial lung biopsy. All the patients were treated with steroid therapy. The most common HRCT finding was bilateral diffuse ground glass opacity (n=7), followed by peribronchial consolidation (n=5) and inter- or intralobular septal thickening (n=2). For the disease distribution, the lower lung zone was dominantly involved. The pathologic results of 7 patients were nonspecific interstitial pneumonia (n=3), bronchiolitis obliterans organizing pneumonia (n=2), hypersensitivity pneumonitis (n=1) and eosinophilic pneumonia (n=1). Irrespective of the pathologic results, all 8 patients improved clinically and radiologically after steroid treatment. The HRCT findings of mixed herbal medicine-induced diffuse infiltrative lung disease were mainly bilateral diffuse ground glass opacity, peribronchial consolidation and dominant involvement of the lower lung zone. Those pathologic findings were nonspecific and the differential diagnosis could include interstitial pneumonia, bronchiolitis obliterans organizing pneumonia, hypersensitivity pneumonitis and eosinophilic pneumonia

  19. Risk factors for peripheral arterial disease in the tropics and its comparison with the western population

    Institute of Scientific and Technical Information of China (English)

    Myla Yacob; Edwin Stephen; Nupur Bit; Mazda Turel; David Sadhu; Sunil Agarwal

    2010-01-01

    Objective:To identify and compare the existence of similar and other risk factors in the perspective of an Indian population. Methods:It was designed as a case control study and was conducted in the Department of General and Vascular Surgery Unit 2 of Christian Medical College, Vellore, India between the periods July 2003 to June 2005. 100 patients with an ABPI<0.9 and 100 controls were studied. Results:Peripheral arterial disease (PAD) was found to be commoner among males (87%). While atherosclerosis was the commonest aetiology (54%), the incidence of Thromboangiitis Obliterans was also not uncommon (38%). Smoking was the main risk factor in the Indian context (83%) as compared to hypercholesterolemia (60%) in the West. The patients with atherosclerotic PAD were middle-aged and had concomitant diabetes (50%) and hypertension (30%). Conclusions:Peripheral arterial disease occurs in a relatively younger age group in India as compared to their Western counterparts. Thromboangiitis Obliterans was found to be a significant aetiology for arterial occlusive disease, with smoking as the primary risk factor followed by diabetes, hypertension and hypercholesterolemia.

  20. Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: Causes, CT-follow up and patient outcome

    International Nuclear Information System (INIS)

    Objective: The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods: Patients with evidence of thoracic air-leakage, i.e. spontaneous pneumomediastinum, spontaneous pneumothorax or interstitial emphysema after allo-HCT were retrospectively identified by a chart review. Acute and follow-up morphology, duration and patient outcome were analyzed on CT (HRCT or MSCT with HR-reconstructions). Correlation was made with histological results of transbronchial biopsy. Results: The 6 patients included (3 male and 3 female, 14-64 years old) with thoracic air-leakage after allo-HCT all had histologically proven bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP). Thoracic air-leakage consisted of spontaneous pneumomediastinum associated with active invasive pulmonary aspergillosis (IPA) in 4/6 and spontaneous pneumothorax or interstitial emphysema each in 1/6 patients. Duration of thoracic air-leakage was 7-135 days. Of the patients with spontaneous pneumomediastinum, 3/4 died of IPA. One patient survived until complete regression of spontaneous pneumomediastinum. One patient died 7 days after spontaneous pneumothorax and one survived developing chronic interstitial emphysema. Conclusion: In all cases, thoracic air-leakage was associated to BO or BOOP. In the majority of cases with additional IPA, thoracic air-leakage is more indicative for severity of pulmonary disease than a life-threatening entity itself

  1. Mixed Herbal Medicine Induced Diffuse Infiltrative Lung Disease: The HRCT and Histopathologic Findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Gyu; Shin, Eun A [Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Joung Sook [Mokdong Hospital, Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    2010-12-15

    The purpose of this study was to evaluate the high-resolution CT (HRCT) and pathologic findings of mixed herbal medicine-induced diffuse interstitial lung disease. Eight patients (6 women and 2 men, age range: 31 to 81 years, mean age: 51.4 years) who presented with cough or dyspnea after taking mixed herbal medicine were included in this study. All the patients underwent plain chest radiography and HRCT. We obtained pathologic specimens from 7 patients via fluoroscopy guided large bore cutting needle biopsy and transbronchial lung biopsy. All the patients were treated with steroid therapy. The most common HRCT finding was bilateral diffuse ground glass opacity (n=7), followed by peribronchial consolidation (n=5) and inter- or intralobular septal thickening (n=2). For the disease distribution, the lower lung zone was dominantly involved. The pathologic results of 7 patients were nonspecific interstitial pneumonia (n=3), bronchiolitis obliterans organizing pneumonia (n=2), hypersensitivity pneumonitis (n=1) and eosinophilic pneumonia (n=1). Irrespective of the pathologic results, all 8 patients improved clinically and radiologically after steroid treatment. The HRCT findings of mixed herbal medicine-induced diffuse infiltrative lung disease were mainly bilateral diffuse ground glass opacity, peribronchial consolidation and dominant involvement of the lower lung zone. Those pathologic findings were nonspecific and the differential diagnosis could include interstitial pneumonia, bronchiolitis obliterans organizing pneumonia, hypersensitivity pneumonitis and eosinophilic pneumonia

  2. Bronchiolitis: adopting a unifying definition and a comprehensive etiological classification.

    Science.gov (United States)

    Papiris, Spyros A; Malagari, Katerina; Manali, Effrosyni D; Kolilekas, Likurgos; Triantafillidou, Christina; Baou, Katerina; Rontogianni, Dimitra; Bouros, Demosthenes; Kagouridis, Konstantinos

    2013-06-01

    Bronchiolitis is an inflammatory and potentially fibrosing condition affecting mainly the intralobular conducting and transitional small airways. Secondary bronchiolitis participates in disease process of the airways and/or the surrounding lobular structures in the setting of several already defined clinical entities, mostly of known etiology, and occurs commonly. Primary or idiopathic bronchiolitis dominates and characterizes distinct clinical entities, all of unknown etiology, and occurs rarely. Secondary bronchiolitis regards infections, hypersensitivity disorders, the whole spectrum of smoking-related disorders, toxic fumes and gas inhalation, chronic aspiration, particle inhalation, drug-induced bronchiolar toxicities, sarcoidosis and neoplasms. Idiopathic or primary bronchiolitis defines clinicopathologic entities sufficiently different to be designated as separate disease entities and include cryptogenic constrictive bronchiolitis, diffuse panbronchiolitis, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, neuroendocrine hyperplasia in infants, bronchiolitis obliterans syndrome in lung and allogeneic hematopoietic cell transplantation, connective tissue disorders, inflammatory bowel disease and bronchiolitis obliterans organizing pneumonia. Most of the above are pathological descriptions used as clinical diagnosis. Acute bronchiolitis, though potentially life threatening, usually regresses. Any etiology chronic bronchiolitis contributes to morbidity and/or mortality if it persists and/or progresses to diffuse airway narrowing and distortion or complete obliteration. Bronchiolitis in specific settings leads to bronchiolectasis, resulting in bronchiectasis.

  3. Lung transplantation in a Chinese single center:7 years of experience

    Institute of Scientific and Technical Information of China (English)

    HE Wen-xin; ZHANG Peng; LIU Ming; JIANG Ge-ning; DING Jia-an; GAO Wen; ZHU Yu-ming; ZHOU Xiao; CHEN Chang; WANG Hao; FAN Jiang

    2011-01-01

    Background Lung transplantation (LT) is a viable option for patients with end-stage lung diseases,but in China,the supply is limited,and the experience with LT is rare too. This study aimed to evaluate the survival and postoperative complications of recipients undergone LT.Methods From January 2003 to May 2010,all patients who underwent LT were included. The clinical data of recipients were analyzed retrospectively,including demographic characteristics,survival rate,and the occurrences of postoperative complications,acute rejection and bronchiolitis obliterans syndrome. Results In total,37 patients underwent LT. The early mortality (<30 days) was 14% (5/37). Cumulative survival rate was 78%,70%,70% and 42% at 1,3,5 and 6 years,respectively. In 37 patients,5 (14%) developed fungal infections,9 (24%)pulmonary bacterial infections,and 6 (16%) had bronchial anastomosis complications after LT. At three months posttransplantation,a significant improvement was observed in lung function (P <0.05). Fifteen recipients (41%) developed acute rejection within the first year. Freedom from bronchiolitis obliterans syndrome was 89%,85% and 80% at 1,2 and 3years after transplantation.Conclusions Despite the limited number of cases,the survival and occurrences of complications after LT were comparable to the international experience. Single LT may be a reasonable option for some patients with end-stage pulmonary diseases.

  4. Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: Causes, CT-follow up and patient outcome

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Monika [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)]. E-mail: monika.vogel@med.uni-tuebingen.de; Brodoefel, Harald [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Bethge, Wolfgang [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Faul, Christoph [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Hartmann, Joerg [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Schimmel, Heiko [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Wehrmann, Manfred [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Claussen, Claus D. [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Horger, Marius [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)

    2006-12-15

    Objective: The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods: Patients with evidence of thoracic air-leakage, i.e. spontaneous pneumomediastinum, spontaneous pneumothorax or interstitial emphysema after allo-HCT were retrospectively identified by a chart review. Acute and follow-up morphology, duration and patient outcome were analyzed on CT (HRCT or MSCT with HR-reconstructions). Correlation was made with histological results of transbronchial biopsy. Results: The 6 patients included (3 male and 3 female, 14-64 years old) with thoracic air-leakage after allo-HCT all had histologically proven bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP). Thoracic air-leakage consisted of spontaneous pneumomediastinum associated with active invasive pulmonary aspergillosis (IPA) in 4/6 and spontaneous pneumothorax or interstitial emphysema each in 1/6 patients. Duration of thoracic air-leakage was 7-135 days. Of the patients with spontaneous pneumomediastinum, 3/4 died of IPA. One patient survived until complete regression of spontaneous pneumomediastinum. One patient died 7 days after spontaneous pneumothorax and one survived developing chronic interstitial emphysema. Conclusion: In all cases, thoracic air-leakage was associated to BO or BOOP. In the majority of cases with additional IPA, thoracic air-leakage is more indicative for severity of pulmonary disease than a life-threatening entity itself.

  5. An automated classification system for the differentiation of obstructive lung diseases based on the textural analysis of HRCT images

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seong Hoon; Seo, Joon Beom; Kim, Nam Kug; Lee, Young Kyung; Kim, Song Soo; Chae, Eun Jin [University of Ulsan, College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Lee, June Goo [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-07-15

    To develop an automated classification system for the differentiation of obstructive lung diseases based on the textural analysis of HRCT images, and to evaluate the accuracy and usefulness of the system. For textural analysis, histogram features, gradient features, run length encoding, and a co-occurrence matrix were employed. A Bayesian classifier was used for automated classification. The images (image number n = 256) were selected from the HRCT images obtained from 17 healthy subjects (n = 67), 26 patients with bronchiolitis obliterans (n = 70), 28 patients with mild centrilobular emphysema (n = 65), and 21 patients with panlobular emphysema or severe centrilobular emphysema (n = 63). An five-fold cross-validation method was used to assess the performance of the system. Class-specific sensitivities were analyzed and the overall accuracy of the system was assessed with kappa statistics. The sensitivity of the system for each class was as follows: normal lung 84.9%, bronchiolitis obliterans 83.8%, mild centrilobular emphysema 77.0%, and panlobular emphysema or severe centrilobular emphysema 95.8%. The overall performance for differentiating each disease and the normal lung was satisfactory with a kappa value of 0.779. An automated classification system for the differentiation between obstructive lung diseases based on the textural analysis of HRCT images was developed. The proposed system discriminates well between the various obstructive lung diseases and the normal lung.

  6. Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children

    Directory of Open Access Journals (Sweden)

    EY Chan

    2005-01-01

    Full Text Available Idiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who presented to a tertiary care centre with recurrent episodes of respiratory distress on a background of baseline tachypnea, chronic hypoxemia and exertional dyspnea. Her past medical history revealed significant lung disease in infancy, including respiratory syncytial virus bronchiolitis and repaired gastroesophageal reflux. She was treated for 'asthma exacerbations' throughout her early childhood years. Bronchiolitis obliterans was subsequently diagnosed with an open lung biopsy. She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. Treatment options remain a dilemma for this patient because there is no known effective treatment for this condition, and the natural history is not well understood. The present case demonstrates the need for careful workup in 'atypical asthma', and the urgent need for further research into the rare lung diseases of childhood.

  7. Treatment of Cytomegalovirus Infection with Cidofovir and CMV Immune Globulin in a Lung Transplant Recipient

    Directory of Open Access Journals (Sweden)

    Heinrike Wilkens

    2016-01-01

    Full Text Available Cytomegalovirus (CMV infection after lung transplantation is associated with increased risk for pneumonitis and bronchiolitis obliterans as well as allograft rejection and opportunistic infections. Ganciclovir is the mainstay of prophylaxis and treatment but CMV infections can be unresponsive. Apart from direct antiviral drugs, CMV immunoglobulin (CMVIG preparations may be considered but are only licensed for prophylaxis. A CMV-seronegative 42-year-old man with cystic fibrosis received a lung from a CMV-seropositive donor. Intravenous ganciclovir prophylaxis was delayed until day 12 due to acute postoperative renal failure and was accompanied by five doses of CMVIG (10 g. By day 16, CMV-DNA was detectable and rising; CMV-specific T-cells were undetectable. Switch from ganciclovir to foscarnet prompted a transient decrease in CMV viral load, but after increasing again to reach 3600 copies/mL foscarnet was changed to intravenous cidofovir and CMVIG was restarted. CMV load continued to fluctuate and declined slowly, whereas CMV-specific T-cells were detected five months later and increased thereafter. At last follow-up, the patient was in very good clinical condition with no evidence of bronchiolitis obliterans. No side effects of this treatment were observed. In this hard-to-treat case, the combination of cidofovir with off-label use of CMVIG contributed to a successful outcome.

  8. Severe Organizing Pneumonia after Two Cycles of Docetaxel as Fourth-Line Chemotherapy for Advanced Non-Small Cell Carcinoma of the Lung

    Directory of Open Access Journals (Sweden)

    Jens Hasskarl

    2009-02-01

    Full Text Available Organizing pneumonia (formerly known as bronchiolitis obliterans organizing pneumonia, BOOP is an inflammatory process of the bronchioles that can lead to the destruction of small airways and surrounding lung tissue. Although the majority of cases are idiopathic, certain chemicals and drugs can induce OP. Here, we report a 54-year-old male patient with advanced non-small cell lung cancer (NSCLC who developed therapy-associated OP. He had undergone several other chemotherapies before being switched to docetaxel as monotherapy (75 mg/m2. Treatment was initially well tolerated, but after the second cycle the patient developed increasing shortness of breath. Computed tomography (CT for staging after the second cycle showed bilateral predominantly interstitial infiltration highly suggestive of acute lung fibrosis. Bronchoscopy revealed signs of chronic bronchitis and watery discharge from both lungs. Bronchoalveolar lavage and transbronchial needle biopsy was performed. Based on histopathologic examination, diagnosis of OP was made. After cessation of docetaxel and initial high dose steroids, the infiltration ameliorated rapidly. This is the second case in the literature that associates docetaxel with rapid onset of bronchiolitis obliterans. Therefore, patients with lung cancer receiving docetaxel who develop respiratory symptoms should be suspected to develop OP.

  9. O espectro clínico e radiológico da pneumonia em organização: análise retrospectiva de 38 casos Clinical and radiographic spectrum of organizing pneumonia: retrospective analysis of 38 cases

    Directory of Open Access Journals (Sweden)

    FABRÍCIO PICCOLI FORTUNA

    2002-11-01

    Full Text Available A pneumonia em organização, acompanhada ou não de bronquiolite obliterante, é uma condição anatomopatológica pulmonar específica com uma grande variedade de apresentações clínicas e radiológicas. A pneumonia em organização pode ser idiopática ou secundária a várias doenças, incluindo infecções e drogas. Objetivos: Descrever as manifestações clínicas, dados radiológicos e espirométricos de pacientes com pneumonia em organização. Métodos: Análise retrospectiva de pacientes com o diagnóstico de pneumonia em organização. Resultados: 38 pacientes foram incluídos na análise. Quatorze apresentavam também condições clínicas relacionadas à pneumonia em organização, e estes mais freqüentemente apresentaram infiltração pulmonar difusa (três de quatro casos e bronquiolite obliterante associada (57% vs. 20%, p = 0,05. Dos 13 pacientes com bronquiolite obliterante associada apenas um era assintomático e dois apresentavam lesões localizadas (15%. De oito pacientes assintomáticos com lesões localizadas, nenhum possuía bronquiolite obliterante associada, e a apresentação radiológica freqüentemente mimetizou carcinoma brônquico. A espirometria de modo geral não contribuiu sobremaneira para o diagnóstico, provavelmente devido à alta prevalência de tabagismo na amostra. Conclusões: A pneumonia em organização possui apresentação clínica e radiológica variada. Fatores que sugerem a ausência de bronquiolite obliterante são a ausência de sintomas e lesões radiológicas localizadas, e esta forma da doença mais freqüentemente deve ser diferenciada de carcinoma brônquico na prática clínica.Organizing pneumonia, whether or not accompanied by bronchiolitis obliterans, is a specific anatomicopathological condition of the lungs that can present in a variety of clinical and radiographic ways. It can be either idiopathic or secondary to a number of diseases, including infection and drugs. Objectives: To

  10. 心踝血管指数、年龄及其交互作用与颈动脉粥样硬化的关联分析

    Institute of Scientific and Technical Information of China (English)

    黄系; 李萍; 张芹; 诸葛张明; 胡华青; 崔寰; 阮积晨; 毛广运

    2014-01-01

    Objective: To explore the correlation between arteriosclerosis early identiifcation and cardio-ankle vascular index (CAVI), age and their interaction.Methods: A cross-sectional study was conducted to ex-plore this association in a Chinese population consisting of 328 participants enrolled from the ordinary medical checkup population in the 1st afifliated hospital of Anhui Medical University. CAVI was measured in duplicate and carotid ultrasound detection was performed in a quiet environment by well-trained physicians. Generalized linear models were conducted to assess the correlation.Results: Prevalence of carotid arteriosclerosis for partici-pants with high, medium and low CAVI score were 90.9%, 57.0% and 19.8%, respectively. After adjusted for the potential confounding factors such as age, gender, body mass index (BMI), low density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), blood pressure (BP), creatinine, education, occupation, psychological ten-sion, cigarette smoking and alcohol drinking, CAVI positively associated with the risk for carotid arteriosclerosis. Compared with participants in the lowest tertile of CAVI (5.15~7.40), those in the medium (7.41~8.65) and high-est (8.66~13.60) had the OR (95% CI) of 2.2 (1.0, 4.9) and 4.4 (1.5, 13.3) for developing carotid arteriosclerosis (P=0.007). Compared with low age groups, the risks of future carotid arteriosclerosis for participants with me- dium and high age increased 7.1 and 51.3 folds, respectively. CAVI and age were all positively associated with the future carotid arteriosclerosis risk (Trend testP<0.001). Compared to subjects with low age and low CAVI, the risks of future carotid arteriosclerosis for participants with low age and high CAVI, high age and low CAVI, high age and high CAVI increased 6.6, 17.3 and 57.1 folds, respectively.Conclusion: CAVI is an independent risk factor of carotid arteriosclerosis, can be used for the prediction of future carotid arteriosclerosis developing and

  11. Association between poor glycemic control, impaired sleep quality, and increased arterial thickening in type 2 diabetic patients.

    Directory of Open Access Journals (Sweden)

    Koichiro Yoda

    Full Text Available Poor sleep quality is an independent predictor of cardiovascular events. However, little is known about the association between glycemic control and objective sleep architecture and its influence on arteriosclerosis in patients with type-2 diabetes mellitus (DM. The present study examined the association of objective sleep architecture with both glycemic control and arteriosclerosis in type-2 DM patients.Cross-sectional study in vascular laboratory.The subjects were 63 type-2 DM inpatients (M/F, 32/31; age, 57.5±13.1 without taking any sleeping promoting drug and chronic kidney disease. We examined objective sleep architecture by single-channel electroencephalography and arteriosclerosis by carotid-artery intima-media thickness (CA-IMT.HbA1c was associated significantly in a negative manner with REM sleep latency (interval between sleep-onset and the first REM period (β=-0.280, p=0.033, but not with other measurements of sleep quality. REM sleep latency associated significantly in a positive manner with log delta power (the marker of deep sleep during that period (β=0.544, p=0.001. In the model including variables univariately correlated with CA-IMT (REM sleep latency, age, DM duration, systolic blood pressure, and HbA1c as independent variables, REM sleep latency (β=-0.232, p=0.038, but not HbA1c were significantly associated with CA-IMT. When log delta power was included in place of REM sleep latency, log delta power (β=-0.257, p=0.023 emerged as a significant factor associated with CA-IMT.In type-2 DM patients, poor glycemic control was independently associated with poor quality of sleep as represented by decrease of REM sleep latency which might be responsible for increased CA-IMT, a relevant marker for arterial wall thickening.

  12. Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve disease

    DEFF Research Database (Denmark)

    Falk, Bo Torkel; Jönsson, Lennart; Olsen, Lisbeth Høier;

    2006-01-01

    Background: The occurrence of small vessel arteriosclerosis in the myocardium, kidney, and lung in dogs with naturally occurring myxomatous mitral valve disease has not been previously investigated systematically. Methods: Twenty-one dogs with naturally occurring congestive heart failure and 21 age......-matched, sex-matched, and weight-matched control dogs underwent extensive pathological and histopathological examination. Morphometry and scoring of tissue sections were used to measure arterial narrowing and fibrosis in the myocardium, kidney, and lung; and intimal thickness and plaque formation in the aorta...... and pulmonary artery. Results: Dogs with congestive heart failure had significantly more arterial narrowing in the left ventricle (Pdogs. However...

  13. Autoevaluación en Enfermería: Educación sanitaria del paciente con isquemia de las extremidades inferiores

    OpenAIRE

    Luis Rodrigo, María Teresa

    2000-01-01

    Juan L.R., jubilado de 72 años de edad, acude al médico por presentar dolor en ambas pantorrillas al caminar aproximadamente 800 metros. Hace 5 años se le diagnosticó diabetes mellitus e hiperlipidemia, que controla adecuadamente con antidiabéticos orales y dieta. La exploración física está dentro de la normalidad, si se exceptúa la disminución del latido en las arterias pedias. El médico diagnostica una arteriosclerosis...

  14. Marcadores de inflamación e insulinorresistencia en la hiperlipemia familiar combinada

    OpenAIRE

    Carratalá Calvo, Arturo

    2014-01-01

    La hiperlipemia familiar combinada (HFC) es un modelo genético de dislipemia mixta con resistencia a la insulina (RI) y elevado riesgo de cardiopatía isquémica por el desarrollo precoz de arteriosclerosis. La RI es independiente del grado de obesidad y del fenotipo lipoproteico. Constituye, además, factor de riesgo cardiovascular en estos pacientes. Actualmente existe una gran evidencia de que en el desarrollo y progresión de la aterosclerosis subyacen mecanismos inmunológicos e inflamator...

  15. Efecto del género y parámetros antropométricos en marcadores de estrés oxidativo e inflamación en situación postprandial

    OpenAIRE

    Ferri Císcar, Jordi

    2015-01-01

    Título Efecto del género y parámetros antropométricos en marcadores de estrés oxidativo e inflamación en situación postprandial Introducción La arteriosclerosis (AE) es la principal causa de las enfermedades cardiovasculares y está relacionada con múltiples factores que son marcadores de inflamación crónica de bajo grado y de estrés oxidativo (EO) contribuyendo desde su inicio en el desarrollo de la disfunción endotelial. La lipemia postprandial (LPP) alterada está asociada co...

  16. Fatty acids and antioxidants in reindeer and red deer

    OpenAIRE

    Sampels, Sabine

    2005-01-01

    The aim of this thesis was to investigate importance of dietary fatty acids (FA) and animal age and sex on FA metabolism. In addition relation between FA and antioxidants on the consequent nutritional and technological quality of reindeer and red deer meat were addressed. A diet rich in polyunsaturated FA (PUFA) especially long chained n-3 FA (≥C20) has beneficial effects on human health, e.g. in prevention of arteriosclerosis. Game meat is a potential food source that is both lean and rich i...

  17. A case study of technology transfer: Cardiology

    Science.gov (United States)

    Schafer, G.

    1974-01-01

    Research advancements in cardiology instrumentation and techniques are summarized. Emphasis is placed upon the following techniques: (1) development of electrodes which show good skin compatibility and wearer comfort; (2) contourography - a real time display system for showing the results of EKGs; (3) detection of arteriosclerosis by digital computer processing of X-ray photos; (4) automated, noninvasive systems for blood pressure measurement; (5) ultrasonoscope - a noninvasive device for use in diagnosis of aortic, mitral, and tricuspid valve disease; and (6) rechargable cardiac pacemakers. The formation of a biomedical applications team which is an interdisciplinary team to bridge the gap between the developers and users of technology is described.

  18. Measure and analyze the brachial-ankle pulse wave velocity of 125 plots%飞行员肢体动脉硬化与吸烟关系分析

    Institute of Scientific and Technical Information of China (English)

    单清; 王惠贤

    2011-01-01

    Objective : To explore the situation and related factors of the arteriosclerosis between the smoking pilots and non - smoking pilots. By means:125 pilots were randomly selected and divided into two groups: smoking group and non - smoking group. Measure the brachial - ankle pulse wave velocity of each pilot by Arteriosclerosis Checking Instrument , record the height , weight , systolic pressure , diastolic pressure , pulse pressure , driving plane period and smoking period of each pilot of the groups and compare the data of Bapwv of different ages between smoking pilots and non - smoking pilots. Results : There was little difference in Bapwv between the smoking pilots and non - smoking pilots with ages younger than 30 and 30 to 39( P >0. 05 ). The Bapwv of the smoking pilots who are over 40 years old are obvious higher than those same age non - smoking pilots( P < 0. 05 ). Conclusion: The brachial - ankle arteriosclerosis situation of the smoking pilots can be diagnosed correspondingly early. And we may prevent , interpose and doctor the arteriosclerosis of the smoking pilots to keep their flight safe.%目的:探讨飞行员肢体动脉硬化程度与吸烟关系.方法:随机选择125名飞行员分为吸烟组和非吸烟组,应用动脉硬化测定仪测定臂踝脉搏波传导速度,同时确定飞行员身高、体重、收缩压、舒张压、脉压、飞行时间等.对比各年龄段吸烟组与非吸烟组飞行员臂踝脉搏波传导速度.结果:30岁以下和30 ~39岁飞行员吸烟组臂踝脉搏波传导速度与非吸烟组无明显差异(P>0.05);40岁以上飞行员吸烟组臂踝脉搏波传导速度较非吸烟组显著升高(P<0.05).结论:通过对臂踝脉搏波传导速度的测定可以相对早期发现飞行员中特别是吸烟飞行员中动脉硬化程度,做到早预防、早干预,确保飞行安全.

  19. Arteria poplitea afklemningssyndrom

    DEFF Research Database (Denmark)

    Lyndrup, Peter; Meyer, Joan N; Schroeder, T V

    1994-01-01

    Popliteal artery entrapment syndrome (PAES) should be suspected in young persons without predisposing factors to arteriosclerosis, who present with unilateral claudication in the calf and foot. This entity results from a developmental abnormal relation between the popliteal artery and the medial...... head of the gastrocnemius muscle. PAES is mostly found in young sportsmen or young soldiers with well-developed muscles. The onset of the symptoms is often sudden, occurring during an episode of intense lower extremity activity. The diagnosis is best established by a thorough clinical examination...

  20. Simulation of Blood Flow at Vessel Bifurcation by Lattice Boltzmann Method

    Institute of Scientific and Technical Information of China (English)

    KANG Xiu-Ying; LIU Da-He; ZHOU Jing; JIN Yong-Juan

    2005-01-01

    @@ The application of the lattice Boltzmann method to the large vessel bifurcation blood flow is investigated in awide range of Reynolds numbers. The velocity, shear stress and pressure distributions at the bifurcation arepresented in detail. The flow separation zones revealed with increase of Reynolds number are located in theareas of the daughter branches distal to the outer corners of the bifurcation where some deposition of particularblood components might occur to form arteriosclerosis. The results also demonstrate that the lattice Boltzmannmethod is adaptive to simulating the flow in larger vessels under a high Reynolds number.

  1. Ultrasonic Imaging of Hemodynamic Force in Carotid Blood Flow

    Science.gov (United States)

    Nitta, N.; Homma, K.

    Hemodynamic forces including blood pressure and shear stress affect vulnerable plaque rupture in arteriosclerosis and biochemical activation of endothelium such as NO production. In this study, a method for estimating and imaging shear stress and pressure gradient distributions in blood vessel as the hemodynamic force based on viscosity estimation is presented. Feasibility of this method was investigated by applying to human carotid blood flow. Estimated results of shear stress and pressure gradient distributions coincide with the ideal distributions obtained by numerical simulation and flow-phantom experiment.

  2. Simulation of Blood Flow at Vessel Bifurcation by Lattice Boltzmann Method

    Science.gov (United States)

    Kang, Xiu-Ying; Liu, Da-He; Zhou, Jing; Jin, Yong-Juan

    2005-11-01

    The application of the lattice Boltzmann method to the large vessel bifurcation blood flow is investigated in a wide range of Reynolds numbers. The velocity, shear stress and pressure distributions at the bifurcation are presented in detail. The flow separation zones revealed with increase of Reynolds number are located in the areas of the daughter branches distal to the outer corners of the bifurcation where some deposition of particular blood components might occur to form arteriosclerosis. The results also demonstrate that the lattice Boltzmann method is adaptive to simulating the flow in larger vessels under a high Reynolds number.

  3. Idiopathic great saphenous phlebosclerosis.

    Directory of Open Access Journals (Sweden)

    Ahmadreza Jodati

    2013-06-01

    Full Text Available Arterial sclerosis has been extensively described but reports on venous sclerosis are very sparse. Phlebosclerosis refers to the thickening and hardening of the venous wall. Despite its morphological similarities with arteriosclerosis and potential morbid consequences, phlebosclerosis has gained only little attention. We report a 72 year old male with paralysis and atrophy of the right leg due to childhood poliomyelitis who was referred for coronary artery bypass surgery. The great saphenous vein, harvested from the left leg, showed a hardened cord-like obliterated vein. Surprisingly, harvested veins from the atrophic limb were normal and successfully used for grafting.

  4. Dieta, estilos de vida y factores de riesgo cardiovascular en niños y adolescentes europeos

    OpenAIRE

    Bel Serrat, Silvia; Moreno Aznar, Luis Alberto; Krogh, Vittorio; Mouratidou, Theodora

    2014-01-01

    La infancia y la adolescencia no sólo se caracterizan por ser periodos de crecimiento rápido y maduración, sino también porque se adquiere el comportamiento alimentario para toda la vida. También se ha observado que las primeras manifestaciones de arteriosclerosis se dan de forma temprana durante la infancia y que, además, están relacionadas con la dieta y otros estilos de vida como la actividad física y los comportamientos sedentarios, entre otros factores. Por todo ello, es de gran importan...

  5. Relationship between taurine and cardiovascular system diseases%牛磺酸与心血管系统疾病的关系

    Institute of Scientific and Technical Information of China (English)

    陈兴荣; 陈玲; 万顺康; 狄勇

    2002-01-01

    @@ Taurine is a kind of β amino acid containing sulfur, and the free amino acid that content is the highest in cells.Recent researches found that taurine is closely related to cardiovascular system.Some documents reported that taurine has apparent treatment effects on many kinds of cardiovascular diseases such as cardiomuscular necrosis,arrhythmia caused by hypercalcemia or hypocalcemia, cardiomuscular ischmia and reperfusion injury[1].It also can resist hypertension,decrease blood cholesterol,increase high density lipoprotein,prevent arteriosclerosis and decrease blood sugar,which had became the main study domain on physical function of taurine.

  6. Observation on Efficiency of Jiangtang (降糖) Capsule in Treating Diabetes Mellitus Type 2 with Hyperlipidemia

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Arteriosclerosis is a major common vascular disorder of diabetes mellitus (DM), and as the life-span of DM patients prolonged, the incidence increased, arteriosclerotic coronary heart disease (CHD) and cerebrovascular diseases have become the principal causes of death of DM. Therefore, improving the disturbance of glucose and lipid metabolism, and preventing chronic complication are the key links in the treatment of DM. The authors used Jiangtang capsule (降糖胶囊, JTC) in treating DM type 2. While treating hypoglycemia, promising effect in improving lipid metabolism disturbance is also obtained. It is reported as follows.

  7. Biomarcadores de la inflamación en la diabetes mellitus tipo 2: Efecto del control glucémico y del fenotipo de las LDL

    OpenAIRE

    Vinagre Torres, Irene

    2015-01-01

    Las enfermedades cardiovasculares constituyen las complicaciones más prevalentes en los pacientes con diabetes mellitus tipo 2 (DM2) y son las que se asocian con mayor morbi-mortalidad. Los mecanismos responsables del desarrollo acelerado de arteriosclerosis en los pacientes con DM2 no se conocen con precisión, pero tanto la dislipemia aterogénica y la inflamación de bajo grado características de esta población, están implicados. La información sobre la relación del grado de control glucémico...

  8. Histone deacetylases and atherosclerosis.

    Science.gov (United States)

    Zheng, Xia-xia; Zhou, Tian; Wang, Xin-An; Tong, Xiao-hong; Ding, Jia-wang

    2015-06-01

    Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam cells. Recently, the question about how to suppress the occurrence of atherosclerosis and alleviate the progress of cardiovascular disease becomes the hot topic. Accumulating evidence suggests that histone deacetylases(HDACs) play crucial roles in arteriosclerosis. This review summarizes the effect of HDACs and HDAC inhibitors(HDACi) on the progress of atherosclerosis.

  9. Progress report 1980/81 of the Austrian Academy of Sciences

    International Nuclear Information System (INIS)

    From the numerous institutes and divisions of the Austrian Academy of Sciences presented in this report the Commission for Arteriosclerosis and Thrombosis Research (application of radioimmunoassay) and the Institute for X-ray Microstructure Research (investigation of biological substances by X-ray and neutron small angle scattering) are partly within the scope of INIS. Fully in scope are short project discriptions of the Institute for Radium Research and Nulear Physics: the Commission for the SIN-project and the Institute for High Energy Physics, completed by publication lists. (G.Q.)

  10. Enfermedad arterial periférica silente en pacientes ingresados en el servicio de urgencia

    OpenAIRE

    Jorge Loría-Castellanos; Angélica Hernández-Cruz

    2011-01-01

    Introducción: La enfermedad arterial periférica (EAP) es un síndrome aterotrombótico que manifiesta la arteriosclerosis sistémica. Su detección en las fases preclínicas (silentes) podría ayudar a detectar a los individuos y poblaciones en riesgo de desarrollar enfermedades aterotrombóticas mayores (cerebrovasculares o coronarias). Material y métodos: Estudio observacional autorizado por el Comité de investigación, en el que a través de un método aleatorio simple se incluyó a pacientes mayores...

  11. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.

    Science.gov (United States)

    Johnston, Y. E.; Duray, P. H.; Steere, A. C.; Kashgarian, M.; Buza, J.; Malawista, S. E.; Askenase, P. W.

    1985-01-01

    In 17 patients with Lyme disease, synovial specimens, obtained by synovectomy or needle biopsy, showed nonspecific villous hypertrophy, synovial cell hyperplasia, prominent microvasculature, lymphoplasmacellular infiltration, and sometimes lymphoid follicles. The larger surgically obtained specimens also showed striking deposition of fibrin in synovial stroma and a form of endarteritis obliterans. In 2 patients, spirochetes were seen in and around blood vessels by the Dieterle silver stain. Compared with 55 cases of other synovial disease, obliterative microvascular lesions were seen only in Lyme synovia, but marked stromal deposition of fibrin seemed nonspecific. These findings imply that the Lyme spirochete may survive for years in affected synovium and may be directly responsible for the microvascular injury. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 PMID:3966535

  12. 婴幼儿肺炎支原体肺炎79例临床分析%Clinical analysis of Mycoplasma pneumoniae pneumonia in 79 infants and young children

    Institute of Scientific and Technical Information of China (English)

    张莹; 赵顺英

    2011-01-01

    目的 探讨婴幼儿肺炎支原体肺炎(MPP)的临床及影像学特点和预后.方法 分析79例MPP患儿的临床表现、影像学及实验室检查结果、治疗及预后.结果 婴幼儿MPP 1岁以上者多见,临床表现以发热、有痰咳嗽为主,70%有喘息,半数可闻及肺部湿啰音和(或)喘鸣音,95%伴有肺外损害,其中心肌酶升高最为常见.双肺均可受累,局部病变部位以右、中下肺受累最常见,多见斑片影、片状密度增高影.病程10 d之后MP-IgM检测100%阳性.多数血细胞计数和C反应蛋白在正常范围.50%以上患儿出现CD4+细胞比值降低,73%总IgE升高.绝大多数患儿存在小气道通气功能损害.19%的患儿表现为重症/难治性肺炎,2例遗留支气管扩张和闭塞性细支气管炎(bronchiolitis obliterans,BO)改变,多数病程中出现喘息者随访1年不再发生喘息.结论 除一般表现外,婴幼儿也可出现重症/难治性MPP(SMPP/RMPP).MPP可继发免疫紊乱、小气道功能障碍,个别病例可出现BO和局限性支气管扩张.%Objective To in vestigate clinical manifestations and radiological findings and prognosis of Mycoplasma pneumoniae pneumonia(MPP) in younger children.Methods Clinical manifestations,radiographic findings,laboratory examinations,treatment effect,and sequelae of 79 children under 3 years old with MPP were analyzed.Results MPP was seen more in young children older than 1 year old. The common clinical manifestations were cough,fever and wheezing. Some patients developed shortness of breath or dyspnea. Scattered tales and expiratory wheezes were beard on chest auscultation. Most cases had at least one extrapulmonary lesion and cardiovascular complications were the most common. Unilateral disease was as common as bilateral. The radiographic findings were predominant with patchy infiltration and consolidation with right middle and lower lung zone. Serum MP-IgM was positive in all patients after 10 days. WBC and CRP were in

  13. [Interpretation and consideration of the Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities management of asymptomatic disease and claudication].

    Science.gov (United States)

    Shen, Chenyang; Li, Weihao

    2016-02-01

    Atherosclerotic occlusive disease of the lower extremities (ASO-LE) has the third highest rate among systematic atherosclerosis obliterans, ranking after coronary heart disease and stoke, and the disease burden of ASO-LE has been continuously increasing. Invasive revascularizations, which is presented by endovascular therapy technique, has undergone a dramatic development in the past couples of decades. However, controversy concerned about the surgical management and operative indications has heated up in the meanwhile. Thus Society for Vascular Surgery (SVS) published the practice guidelines for ASO-LE with asymptomatic disease and claudication in March, 2015. At the first time the guideline definitely opposed the aggressive invasive revascularization for ASO-LE patients with asymptomatic disease or claudication under satisfied tolerance. Instead, it posed the extreme emphasis on the pharmacotherapy with risk reduction of atherosclerosis at the core and the exercise therapy with supervised or home-based exercise program at the core for ASO-LE patients with asymptomatic disease and claudication.

  14. Primary extranodal non-Hodgkin's lymphoma of the lung presenting with bilateral, patchy infiltrates dramatically improving after corticosteroid therapy.

    Science.gov (United States)

    Boon, E S; Graal, M B; van Noord, J A

    1993-10-01

    A 63-year-old man was admitted to the hospital with fever and bilateral, peripheral infiltrates. Infectious disease and malignancy seemed to be excluded by fiberoptic diagnostic procedures. Subsequently, respiratory insufficiency developed, making open lung biopsy impossible. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was strongly considered and treatment with corticosteroids was started; this led to dramatic clinical and radiologic improvement for a short time. Eventually, an open lung biopsy specimen disclosed primary extranodal non-Hodgkin's lymphoma of T-cell origin, immunoblastic, of high-grade malignancy according to the Kiel classification. After the first course of chemotherapy, total respiratory insufficiency developed and the patient died. This case is unique in a patient without AIDS.

  15. Computed tomography findings of postoperative complications in lung transplantation; Achados tomograficos nas complicacoes pos-operatorias do transplante pulmonar

    Energy Technology Data Exchange (ETDEWEB)

    Hochhegger, Bruno; Irion, Klaus Loureiro; Marchiori, Edson; Bello, Rodrigo; Moreira, Jose; Camargo, Jose Jesus [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Postgraduate Program in Respiratory Sciences; Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Postgraduate Program in Radiological Sciences], e-mail: brunorgs@mail.ufsm.br

    2009-03-15

    Due to the increasing number and improved survival of lung transplant recipients, radiologists should be aware of the imaging features of the postoperative complications that can occur in such patients. The early treatment of complications is important for the long-term survival of lung transplant recipients. Frequently, HRCT plays a central role in the investigation of such complications. Early recognition of the signs of complications allows treatment to be initiated earlier, which improves survival. The aim of this pictorial review was to demonstrate the CT scan appearance of pulmonary complications such as reperfusion edema, acute rejection, infection, pulmonary thromboembolism, chronic rejection, bronchiolitis obliterans syndrome, cryptogenic organizing pneumonia, post transplant lymphoproliferative disorder, bronchial dehiscence and bronchial stenosis. (author)

  16. High-resolution computed tomography findings in pulmonary complications after bone marrow transplantation: iconographic essay; Tomografia computadorizada de alta resolucao nas complicacoes pulmonares pos-transplante de medula ossea: ensaio iconografico

    Energy Technology Data Exchange (ETDEWEB)

    Gasparetto, Emerson L.; Ono, Sergio E.; Souza, Carolina A. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Radiologia Medica e Diagnostico por Imagem]. E-mail: gasparetto@hotmail.com; Escuissato, Dante L. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina. Disciplina de Radiologia Medica; Rocha, Gabriela de Melo; Inoue, Cezar; Falavigna, Joao M. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina; Marchiori, Edson [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Universidade Federal, Rio de Janeiro (UFRJ), RJ (Brazil). Curso de Pos-graduacao em Radiologia

    2005-12-01

    Bone marrow transplantation has been the treatment of choice for many hematologic diseases. However, pulmonary complications, which may occur in up to 60% of the patients, are the main cause of treatment failure and may be divided in three phases according to the patient's immunity. In the first phase, up to 30 days after the procedure, there is a predominance of non-infectious complications and fungal pneumonia. Viral infections, mainly by cytomegalovirus, are common in the second phase (up to 100 days after bone marrow transplantation). Finally, in the late phase after bone marrow transplantation, non-infectious complications as bronchiolitis obliterans organizing pneumonia and graft-versus-host disease are most commonly seen. The authors present a pictorial essay of the high-resolution computed tomography findings in patients with pulmonary complications after bone marrow transplantation. (author)

  17. Beyond pneumonoconiosis: Recently described occupational interstitial lung diseases

    Directory of Open Access Journals (Sweden)

    Evangelia Nena

    2010-01-01

    Full Text Available SUMMARY. Recent technological innovations have resulted in the introduction of new substances in different manufacturing procedures. Unfortunately, lack of knowledge of the adverse effects of some novel substances has led to the development of interstitial lung disease (ILD among exposed workers. Exposure to diacetyl can cause bronchiolitis obliterans (“popcorn lung”, while exposure to nylon flock, Acramin-FWN, indium-tin oxide, biomass fuels or nanoparticles is associated with ILD. In addition, hypersensitivity pneumonitis can occur after exposure to additives in animal feed. Finally, new applications of substances already known to be hazardous can result in the occurrence of ILD in exposed workers. Pneumon 2010, 23(3:293-300.

  18. Cryptogenic Organising Pneumonia As The Initial Presenting Manifestation of SLE

    Directory of Open Access Journals (Sweden)

    Neena Mampilly

    2015-07-01

    Full Text Available Cryptogenic Organising Pneumonia (COP, also called idiopathic Bronchiolitis Obliterans Organising Pneumonia( BOOP, is a distinct entity among the idiopathic interstitial pneumonias defined histopathologically by intraalveolar buds of granulation tissue. The etiology includes idiopathic, infectious, drug induced radiation induced and connective tissue diseases. Organising pneumonia occurs particularly in patients with dermatomyositis-polymyositis where it may be the presenting manifestation, and rarely in SLE, rheumatoid arthritis, scleroderma and other connective tissue diseases. We describe a 30 yr old lady who initially presented with respiratory symptoms, not responding to antibiotics. She was subsequently diagnosed as SLE and HRCT thorax showed consolidation involving both lung fields. A percutaneous lung biopsy revealed features of Cryptogenic Organising Pneumonia.

  19. Belatacept for Maintenance Immunosuppression in Lung Transplantation

    Directory of Open Access Journals (Sweden)

    Christine Hui PharmD

    2014-06-01

    Full Text Available Belatacept is a novel immunosuppressant that blocks a T-cell costimulation pathway and is approved for use in adult kidney transplant recipients. Its safety and efficacy have not been established after lung transplantation. We present a case of a lung transplant recipient treated with belatacept. A 56-year-old man underwent bilateral lung retransplantation for bronchiolitis obliterans syndrome (BOS. In the third year posttransplant, he developed hemolytic uremic syndrome (HUS attributed to tacrolimus. Tacrolimus was changed to sirolimus. One month later, he presented with worsening renal function and HUS attributed to sirolimus. Plasmapheresis and steroid pulse were initiated with clinical improvement, and sirolimus was switched to belatacept. He experienced no episodes of cellular rejection but developed recurrent BOS. Complications during treatment included anemia and recurrent pneumonias. The safety and efficacy of belatacept in lung transplantation remains unclear; further studies are needed.

  20. Acute viral bronchiolitis and its sequelae in developing countries.

    Science.gov (United States)

    Fischer, Gilberto Bueno; Teper, Alejandro; Colom, Alejandro J

    2002-12-01

    Acute viral bronchiolitis (AVB) is a common disease found throughout the world. Various aspects of it are being studied: its epidemiology, diagnosis, prognosis and treatment. Most of these studies are being conducted in developed countries, with only a few taking place in developing countries. Risk factors such as poor nutrition, an adverse environment and early weaning should be studied where these features are common. Treatment aspects such as cost-effectiveness in low income settings need further study. Use of ribavirin and respiratory syncytial virus (RSV)-immunoglobulin are good examples. Post-bronchiolitic sequelae also need to be studied in low income countries. There is evidence that bronchiolitis obliterans is unusually frequent in some Latin-American countries such as Argentina and Brazil. It will be helpful to undertake combined studies in countries with the same socio-economics, investigating the preventive and management aspects of AVB and its sequelae to reduce the morbidity and mortality.

  1. Swyer-James-Macleod Syndrome Presenting with Pulmonary Hypertension

    Directory of Open Access Journals (Sweden)

    Sh Hajsadeghi

    2010-09-01

    Full Text Available Swyer–James–MacLeod Syndrome is a rare condition as a result of childhood pulmonary infection, especially bronchiolitis obliterans or viral bronchiolitis/pneumonia. It appears as increased radiolucency on chest Xray, in the absence of obstructing lesions and can be confused for other thoracic disease processes such as a large pulmonary emboli or congenital bronchial and/or pulmonary vasculature malformations. We introduce a 46-year-old male patient presented with symptoms and signs of pulmonary hypertension which was initially misdiagnosed as chronic pulmonary emboli. This case highlights the possibility of pulmonary hypertension to be one of the cardinal manifestations of this syndrome, and outlines the significance of application of computedtomography in confirming the diagnosis of SJMS and in eliminating other diseases.

  2. Interstitial inflammatory lesions of the pulmonary allograft: a retrospective analysis of 2697 transbronchial biopsies

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.;

    2008-01-01

    of 2697 biopsies were evaluated corresponding to a mean of 6+/-2 (median 8) completed schedules per patient. Diffuse alveolar damage (DAD) was the second most common histological finding within the first 2 weeks after transplantation. The peak prevalence of bronchiolitis obliterans organizing pneumonia......, incidence and possible associations between commonly identified inflammatory and fibrotic lesions in the pulmonary allograft. METHODS: Retrospective chart review of all transbronchial biopsies performed within the first 2 years of 299 lung-transplanted patients in the period 1996 to 2006. RESULTS: A total.......0001, respectively). Acute cellular rejection was not associated with DAD, and patients with lymphocytic bronchiolitis were not more likely to demonstrate features of organizing pneumonia (DAD or BOOP). CONCLUSIONS: Histologic findings of ACR, lymphocytic bronchiolitis, BOOP, and interstitial pneumonitis were...

  3. Hazy increased density in diffuse lung disease

    International Nuclear Information System (INIS)

    In order to determine the significance of ground glass density on high-resolution CT scans of patients with idiopathic pulmonary fibrosis and other lung disorders, the authors have reviewed 200 high-resolution CT studies and found 50 cases demonstrating areas of hazy increased lung density. Disease entities most often associated with this finding included DIP, UIP, alveolar proteinosis, sarcoidosis, and bronchiolitis obliterans/ organizing pneumonia. Pathologic examination revealed either cellular or fluid material lining terminal air spaces, often associated with alveolar wall infiltration and an absence of fibrosis. Gallium scans and bronchoalveolar lavage in some cases showed active inflammation Follow-up high-resolution CT studies in 10 patients showed either change or resolution of the hazy densities, confirming the presence of a reversible parenchymal lesion

  4. Penis cancer: a case report

    Directory of Open Access Journals (Sweden)

    Gregorio Sampalmieri

    2014-06-01

    Full Text Available Penis cancer appears as a small lesion that extends gradually to affect the whole of the glans and the shaft of the penis. Its peak incidence is in men aged 40 to 70 years. The most frequent malignant penis tumour is squamous cell carcinoma, which occurrence is probably favoured by smegma accumulation, HPV16 and 18 infection, smoke, and balanitis xerotica obliterans. Here we discuss the case of a 74-year-old man with sovrapubic pain and swelling. Physical examination reveals swollen glans with purulent secretions and oedema. The final diagnosis of squamous cell carcinoma is established by means of RMN and biopsy. Partial penectomy surgery follows. Histopathological examination shows poorly differentiated endophytic infiltrative growth. The tumour infiltrates corpus spongiosum, corpora cavernosa, and urethra. The proximal uretheral stump is free from infiltration (pT3.http://dx.doi.org/10.7175/cmi.v8i2.906 

  5. Invasive pulmonary aspergillosis 10 years post bone marrow transplantation: a case report

    Directory of Open Access Journals (Sweden)

    Rashid Rifat

    2009-01-01

    Full Text Available Abstract Introduction Invasive pulmonary aspergillosis is a leading cause of mortality and morbidity in bone marrow transplant recipients. Establishing the diagnosis remains a challenge for clinicians working in acute care setting. However, prompt diagnosis and treatment can lead to favourable outcomes Case presentation We report a case of invasive aspergillosis occurring in a 39-year-old Caucasian female 10 years after an allogeneic haematopoietic bone marrow transplant, and 5 years after stopping all immunosuppression. Possible risk factors include bronchiolitis obliterans and exposure to building dust (for example, handling her husband's dusty overalls. There are no similar case reports in the literature at this time. Conclusion High clinical suspicion, especially in the setting of failure to respond to broad-spectrum antibiotics, should alert clinicians to the possibility of invasive pulmonary aspergillosis, which, in this case, responded to antifungal therapy.

  6. Blood supply and vasculature of mycetoma.

    Science.gov (United States)

    Fahal, A H; el Hag, I A; Gadir, A F; el Lider, A R; el Hassan, A M; Baraka, O Z; Mahgoub, E S

    1997-01-01

    The blood supply to the mycetoma lesion and its vasculature were studied in patients with various types of mycetoma using histological, ultrastructural, angiographic and sonographic techniques. The mycetoma lesion proved to be well vascularized. However, certain vascular abnormalities were demonstrated. In histological sections, the small arteries and arterioles showed medial muscular hypertrophy in 83%, intimal fibrosis in 33%, arteritis in 7% and endarteritis obliterans with narrowed lumen in 7% of the patients. No vascular occlusion, ischaemic changes or arteriovenous shunts were observed. These changes were confirmed ultrastructurally. Angiography of the lesion showed a brisk pathological circulation which was more evident in eumycetoma. The vascular Doppler study showed normal blood flow pattern in the affected limb. Regional intra-arterial chemotherapy for mycetoma is suggested as a possible treatment modality. PMID:9147269

  7. [Gastro-esophageal reflux and chronic respiratory diseases].

    Science.gov (United States)

    Dirou, S; Germaud, P; Bruley des Varannes, S; Magnan, A; Blanc, F-X

    2015-12-01

    Gastroesophageal reflux disease (GERD) frequently occurs in association with chronic respiratory diseases although the casual link is not always clear. Several pathophysiological and experimental factors are considered to support a role for GERD in respiratory disease. Conversely, respiratory diseases and bronchodilator treatment can themselves exacerbate GERD. When cough or severe asthma is being investigated, GERD does not need to be systematically looked for and a therapeutic test with proton pump inhibitors is not always recommended. pH impedance monitoring is now the reference diagnostic tool to detect non acid reflux, a form of reflux for which proton pump inhibitor treatment is ineffective. Recent data have shown a potential role of GERD in idiopathic pulmonary fibrosis and bronchiolitis obliterans following lung transplantation, leading to discussions about the place of surgery in this context. However, studies using pH impedance monitoring are still needed to better understand and manage the association between GERD and chronic respiratory diseases.

  8. The challenge of chronic lung disease in HIV-infected children and adolescents

    Directory of Open Access Journals (Sweden)

    Heinrich C Weber

    2013-06-01

    Full Text Available Until recently, little attention has been given to chronic lung disease (CLD in HIV-infected children. As the HIV epidemic matures in sub-Saharan Africa, adolescents who acquired HIV by vertical transmission are presenting to health services with chronic diseases. The most common is CLD, which is often debilitating. This review summarizes the limited data available on the epidemiology, pathophysiology, clinical picture, special investigations and management of CLD in HIV-infected adolescents. A number of associated conditions: lymphocytic interstitial pneumonitis, tuberculosis and bronchiectasis are well described. Other pathologies such as HIV-associated bronchiolitis obliterans resulting in non-reversible airway obstruction, has only recently been described. In this field, there are many areas of uncertainty needing urgent research. These areas include the definition of CLD, pathophysiological mechanisms and common pathologies responsible. Very limited data are available to formulate an effective plan of investigation and management.

  9. Plaque of atherosclerosis in aorta: review on atherogenesis, formation of plaque, clinical significance, methods of imaging and treatment

    International Nuclear Information System (INIS)

    There is a certain consensus in the literature that the earliest stage of atherogenesis is characterized by the accumulation of spongy cells in the region of the intimal artery. Risk factors such as arterial hypertension, smoking, diabetes mellitus, hypercholesterolemia, male gender and advanced age predispose a person to the formation of plaques in the coronaries and aorta. A greater number of acute coronary events as well as strokes have been observed in people with these risk factors. Strokes are the third cause of death in the USA, with about 40% of the cases being of cryptogenic origin. Since 1989 the atheroma plaques which develop in the thoracic aorta have been considered to be responsible for cerebral and peripheral strokes which were previously considered cryptogenic because imaging techniques such as electrocardiogram transesophageal, computerized tomogram, nuclear magnetic angio-resonance have visualized and characterized the lesions with plaques of arteriosclerosis in the thoracic aorta. The authors of this article made a systematic review in the PUBMED about arteriosclerosis in the aorta and its diagnostic methods. This review includes the physiopathology of the formation of atheroma to the aorta and its consequences, diagnostic methods such as echo transesophageal, computerized tomogram and angio resonance, as well as the advantages and disadvantages of each method of identification of the lesions. An analysis of the clinical significance of the size, form and location of the atheroma plaques in the thoracic aorta were made based on clinical studies, as well as their treatment with anticoagulants, antiplatelet and drugs to reduce cholesterol. (author)

  10. Hyperuricemia and carotid artery dilatation among young adults without metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Eswar Krishnan

    2012-10-01

    Full Text Available It is not known if hyperuricemia is associated with early vascular changes signifying arteriosclerosis. We performed a cross sectional study of 163 young adults without metabolic syndrome in Allegheny County, PA, USA. Doppler ultrasound was used to measure two metrics of early arteriosclerosis: carotid artery dimensions and aortic pulse wave velocity. Individuals in the highest quartiles of serum uric acid (>6.2 mg/dL for men and >4.6 for women were more likely to be of younger age, and to possess greater measures of adiposity and an adverse cardiovascular risk profile. Higher serum uric acid concentration was associated with larger luminal and adventitial diameters as well as changes in diameters between the phases of the cardiac cycle (P<0.001 but not with carotid intima media thickness, pulse wave velocity, or pressure strain modulus. In multivariable linear regression models where the effects of age, ethnicity, serum creatinine, systolic blood pressure, current alcohol use, body mass index and smoking status were accounted for, the highest quartile of serum uric acid was associated with greater luminal and adventitial diameters and change in luminal diameter between the phases of cardiac cycle (P<0.05, but not with pulse wave velocity, pressure strain modulus or carotid intima media thickness. We can conclude that hyperuricemia is associated with larger carotid artery diameters signifying an early adaptive response to vascular stress. This has implications on the observed link between hyperuricemia and hypertension.

  11. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.

    Science.gov (United States)

    Ohsawa, Ikuroh; Nishimaki, Kiyomi; Yamagata, Kumi; Ishikawa, Masahiro; Ohta, Shigeo

    2008-12-26

    Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688-694]. Here, we investigated whether drinking H(2)-dissolved water at a saturated level (H(2)-water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE(-/-)), a model of the spontaneous development of atherosclerosis. ApoE(-/-) mice drank H(2)-water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H(2)-water (p=0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H(2)-dissolved water has the potential to prevent arteriosclerosis. PMID:18996093

  12. Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear.

    Directory of Open Access Journals (Sweden)

    Giselle Chamberlain

    Full Text Available Mesenchymal stem cells (MSCs have anti-inflammatory and immunosuppressive properties and may be useful in the therapy of diseases such as arteriosclerosis. MSCs have some ability to traffic into inflamed tissues, however to exploit this therapeutically their migratory mechanisms need to be elucidated. This study examines the interaction of murine MSCs (mMSCs with, and their migration across, murine aortic endothelial cells (MAECs, and the effects of chemokines and shear stress. The interaction of mMSCs with MAECs was examined under physiological flow conditions. mMSCs showed lack of interaction with MAECs under continuous flow. However, when the flow was stopped (for 10 min and then started, mMSCs adhered and crawled on the endothelial surface, extending fine microvillous processes (filopodia. They then spread extending pseudopodia in multiple directions. CXCL9 significantly enhanced the percentage of mMSCs adhering, crawling and spreading and shear forces markedly stimulated crawling and spreading. CXCL9, CXCL16, CCL20 and CCL25 significantly enhanced transendothelial migration across MAECs. The transmigrated mMSCs had down-regulated receptors CXCR3, CXCR6, CCR6 and CCR9. This study furthers the knowledge of MSC transendothelial migration and the effects of chemokines and shear stress which is of relevance to inflammatory diseases such as arteriosclerosis.

  13. Histopathological analysis of pre-implantation donor kidney biopsies: association with graft survival and function in one year post-transplantation

    Directory of Open Access Journals (Sweden)

    Karla Lais Pêgas

    2014-04-01

    Full Text Available Introduction: Pre-implantation kidney biopsy is a decision-making tool when considering the use of grafts from deceased donors with expanded criteria, implanting one or two kidneys and comparing this to post-transplantation biopsies. The role of histopathological alterations in kidney compartments as a prognostic factor in graft survival and function has had conflicting results. Objective: This study evaluated the prevalence of chronic alterations in pre-implant biopsies of kidney grafts and the association of findings with graft function and survival in one year post-transplant. Methods: 110 biopsies were analyzed between 2006 and 2009 at Santa Casa de Porto Alegre, including live donors, ideal deceased donors and those with expanded criteria. The score was computed according to criteria suggested by Remuzzi. The glomerular filtration rate (GFR was calculated using the abbreviated MDRD formula. Results: No statistical difference was found in the survival of donors stratified according to Remuzzi criteria. The GFR was significantly associated with the total scores in the groups with mild and moderate alterations, and in the kidney compartments alone, by univariate analysis. The multivariate model found an association with the presence of arteriosclerosis, glomerulosclerosis, acute rejection and delayed graft function. Conclusion: Pre-transplant chronic kidney alterations did not influence the post-transplantation one-year graft survival, but arteriosclerosis and glomerulosclerosis is predictive of a worse GFR. Delayed graft function and acute rejection are independent prognostic factors.

  14. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats

    Directory of Open Access Journals (Sweden)

    Yuko Inami

    2014-01-01

    Full Text Available Aim. Chronic kidney disease (CKD represents endothelial dysfunction. Monocyte adhesion is recognized as the initial step of arteriosclerosis. Indoxyl sulfate (IS is considered to be a risk factor for arteriosclerosis in CKD. Oral adsorbent AST-120 retards deterioration of renal function, reducing accumulation of IS. In the present study, we determined the monocyte adhesion in the adenine-induced uremic rats in vivo and effects of AST-120 on the adhesion molecules. Methods. Twenty-four rats were divided into control, control+AST-120, adenine, and adenine+AST-120 groups. The number of monocytes adherent to the endothelium of thoracic aorta by imaging the entire endothelial surface and the mRNA expressions of adhesion and atherosclerosis-related molecules were examined on day 49. The mRNA expressions of ICAM-1 and VCAM-1 in human umbilical vein endothelial cells were also examined. Results. Adenine increased the number of adherent monocytes, and AST-120 suppressed the increase. The monocyte adhesion was related to serum creatinine and IS in sera. Overexpression of VCAM-1 and TGF-β1 mRNA in the arterial walls was observed in uremic rats. IS induced increase of the ICAM-1 and VCAM-1 mRNA expressions in vitro. Conclusion. It appears that uremic condition introduces the monocyte adhesion to arterial wall and AST-120 might inhibit increasing of the monocyte adherence with CKD progression.

  15. ME 04-2 AORTIC PWV FOR RISK STRATIFICATION IN HYPERTENSION.

    Science.gov (United States)

    Park, Jeong Bae

    2016-09-01

    High pressure of the blood in artery is a common condition and it is closely related to cardiovascular (CV) diseases in future. Blood pressure itself is the most important criteria for hypertension prognosis but attempts are being made to detect hypertensive vascular changes early. Healthy arteries are flexible, strong and elastic but if the condition of high blood pressure persists, arteries turn narrow, thick and stiff, become a condition of arteriosclerosis. And so now, pulse wave velocity (PWV) which measures arteriosclerosis became one of the clinically significant method that evaluates CV risks among patients in hypertension (yes, it is also very important for general population), detects biological changes in blood vessels caused by hypertension, and it is known as a guide for hypertension management.Other than hypertension, the importance of PWV on various pathological status such as diabetes and renal diseases has been known and it is widely used in clinical settings. There is a method which measures PWV between two blood vessels, regional PWV and arterial structure in one particular blood vessel site, local PWV. Controversies still exist over its accuracy but most of them were resolved and so now, it was introduced as a standard technique by American Heart Association (AHA), European Society of Hypertension and others. Once the problem of pricing is resolved, it can be broadly used as inexpensive technique in clinical settings. I will further discuss which PWV techniques to use and how to interpret aortic PWV data in CV risk stratification of hypertension in clinical settings. PMID:27643282

  16. 不同年龄女性超重和肥胖与动脉僵硬度的相关性研究%Association of overweight/obesity with arterial stiffness in females

    Institute of Scientific and Technical Information of China (English)

    陆昀; 沈振海; 李红卫; 李凤; 恽景廷

    2014-01-01

    Objective To evaluate the association of body weight with brachial-ankle pulse wave velocity (baPWV) in females.Methods A total of 2 921 residents (≥20 years old) were selected by the stratified cluster random sampling method from March to December 2011.Arterial stiffness was assessed by baPWV.Multivariate logistic regression analysis was used to evaluate the effect of body mass index (BMI) on arteriosclerosis.The predictive value of BMI to evaluate arteriosclerosis was analyzed by using receiver operation characteristic (ROC) curve.Results The prevalence of arteriosclerosis was significantly increased in overweight/obese residents (P<0.01).BMI was positively correlated with baPWV (r=0.310,P<0.01).The prevalence of increased arterial stiffness in individuals≥65 years older was higher than that in people of 20-40 or 41-64 years old (x2 values were 677.30 and 347.26,respectively; both P<0.01).For females of 20-40 or 41-46 years old,the prevalences of increased arterial stiffness in overweight and obese groups were higher than those in normal body weight group (both P<0.01).In univariate analysis,age,resting heart rate,systolic blood pressure (SBP) and diastolic blood pressure (DBP) were correlated with arteriosclerosis (all P<0.01).The odds ratio for the prevalence of arteriosclerosis in overweight women was 2.017 (95% confidence interval (CI):1.637-2.486,P<0.01) and that in obese women was 2.759 (95% CI:1.964-3.876,P<0.01) after adjustment for age,resting heart rate and blood pressure.The area under the ROC curve was 0.693 (95% CI:0.671-0.715,P<0.01) to evaluate arteriosclerosis in females and the optimal cut-off point for BMI was 23.42 kg/m2.Conclusions For females,overweight and obesity may be risk factors of arteriosclerosis.The optimal cut-off point for BMI to evaluate arteriosclerosis in women could be 23.42 kg/m2.%目的 探讨女性人群不同体重与臂踝脉搏波速度(baPWV)的关系,评估超重和肥胖女性人群的

  17. Juvenile elastic arteries after 28 years of renal replacement therapy in a patient with complete complement C4 deficiency

    Directory of Open Access Journals (Sweden)

    Knoll Florian

    2012-12-01

    Full Text Available Abstract Background Complement activation products are present in atherosclerotic plaques. Recently, binding of complement to elastin and collagen in the aortic wall has been demonstrated, suggesting a role of complement in the development aortic stiffness and atherosclerosis. The definitive role of complement in atherosclerosis and arteriosclerosis, however, remains unclear. Case presentation We here describe a patient with hereditary complete deficiency of complement C4 suffering from Henoch-Schoenlein purpura and on renal replacement therapy for twenty-eight years. The patient had the full range of risk factors for vascular damage such as hypertension, volume overload, hyperphosphatemia and hyperparathyroidism. Despite that, his carotid artery intima media thickness was below the normal range and his pulse wave velocity was normal. In contrast, the patient’s coronary and peripheral muscular arteries were heavily calcified. Conclusion This case supports the hypothesis that complement plays an important role in the development of stiffness of elastic arteries. We speculate that inability to activate complement by the classical or lectin pathways protected the patient from atherosclerosis, arteriosclerosis, stiffening and calcification of the aorta and carotid arteries. Inhibition of complement activation may be a potential target for prophylactic and therapeutic interventions.

  18. Radiotherapy-induced aortic valve disease associated with porcelain aorta

    International Nuclear Information System (INIS)

    Mediastinal irradiation has been reported to induce cardiac disease such as pericarditis, valvular dysfunction, conduction abnormalities, accelerated arteriosclerosis of the coronary arteries, and also calcifications of the ascending aorta. We herein describe a case of radiotherapy-induced porcelain aorta and aortic valve disease and their surgical treatment. The patient was diagnosed with myasthenia gravis (MG) in 1965 (Osserman's type II), and mediastinal irradiation was performed in 1970 for treatment of thymic tumor associated with MG. Thirty years after radiation therapy, complete atrioventricular block and aortic valve disease with severe calcification of the ascending aorta and aortic arch (porcelain aorta) were detected on echo cardiogram and cardiac catheterization. A permanent pacemaker was implanted via the left subclavian vein and aortic valve replacement was performed under extracorporeal circulation established by selective cerebral perfusion and balloon occlusion instead of aortic cross-clamping. As no risk factors of arteriosclerosis such as hypercholesterolemia, hyperglycemia and hypertension were apparent, we concluded that the aortic valve disease and porcelain aorta were primarily induced by radiotherapy. (author)

  19. A novel photoplethysmography technique to derive normalized arterial stiffness as a blood pressure independent measure in the finger vascular bed

    International Nuclear Information System (INIS)

    Stiffening of the small artery may be the earliest sign of arteriosclerosis. However, there is no adequate method for directly assessing small arterial stiffness. In this study, the finger arterial elasticity index (FEI) was defined as the parameter n which denotes the curvilinearity of an exponential model of pressure (P)–volume (Va) relationship (Va = a − b exp (−nP)). For the original estimation, the FEI was calculated from a compliance index from the finger photoplethysmogram whilst occluding the finger. A simple estimation of the FEI was devised by utilizing normalized pulse volume instead of the compliance index. Both estimations yielded close agreement with the exponential model in healthy young participants (study 1: n = 19). Since the FEI was dependent on finger mean blood pressure, normalized finger arterial stiffness index (FSI) was defined as standardized residual from their relationship: mean and standard deviation (SD) of the FSI were 50 ± 10 (study 2: n = 174). The mean coefficient of variation of the FSI for four measurements was 5.72% (study 3: n = 6). The mean and SD of the FSI in seven arteriosclerotic patients were 100.0 ± 13.5. In conclusion, the FEI and FSI by simple estimation are valid and useful for arteriosclerosis research

  20. 超重和肥胖与动脉僵硬度的相关性研究%Association between overweight, obesity and arterial stiffness in community residents

    Institute of Scientific and Technical Information of China (English)

    黄晖明; 李森; 许浩

    2011-01-01

    Objective To evaluate the relationship between overweight,obesity and arterial stiffness in community residents.Methods A total of 4585 community-dwelling adults in Jiangsu province,China were surveyed with the method of stratified and cluster sampling from 2007 to 2009.Overweight and obesity were defined by body mass index (BMI) and arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV).Statistical analysis of arteriosclerosis included multivariate logistic regression testing among which BMI was viewed as continuous variable( 1 kg/m2 increasing to BMI)and categorical variables (underweight,normal,overweight and obesity) respectively.Odds ratio,population attributable risk percent and the optimal cut-off points for BMI to evaluate arteriosclerosis were analyzed using receiver operator characteristic (ROC) curve.Results ( 1 ) After age control,BMI of male or female were positively correlated with baPWV (r =0.213,P <0.01; r =0.186,P <0.01).baPWV and prevalence of arteriosclerosis were significantly higher in obese residents compared with normal body weight group ( all P < 0.01 ).(2)As a continuous variable,the odds ratio value of BMI on predicting arteriosclerosis was 1.146 (95%CI:1.117 - 1.175,P < 0.01 ) after adjusting of age,gender and hypertension.As categorical variables,the odds ratio value of BMI was 0.369(95% CI:0.141 -0.962,P <0.05) for underweight group,1.576 (95% CI:1.333 - 1.863 ) for overweight group and 2.087 ( 95% CI:1.615 - 2.698 ) for obesity group (all P <0.01 ).(3) The population attributable arteriosclerosis risk was 19.1% and 11.6%in overweight and obesity groups,respectively.The area under the ROC curve was 0.661 (95% CI:0.645 -0.678,P < 0.01 ) and the optimal cut-off point for BMI to evaluate arteriosclerosis was 24.25 kg/m2.Conclusions Overweight and obese residents faced higher risk for arteriosclerosis than normal population.Overweight and obesity are independent risk factors for

  1. Plaque of atherosclerosis in aorta: review on atherogenesis, formation of plaque, clinical significance, methods of imaging and treatment; Placa de aterosclerose em aorta: revisao sobre aterogenese, formacao de placa, significado clinco, metodos de imagens e tratamento

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, Rogerio Gomes; Nunes, Colandy G. de Oliveira; Rassi Junior, Luis; Melato, Luciano Henrique; Turco, Fabio de Paula; Borges, Moises Marcos, E-mail: rogerinhofurtado@gmail.com [Centro de Diagnostico por Imagem (CDI), Goiania, GO (Brazil); Sara, Leonardo [Instituto do Coracao (InCor/FM/USP), Sao Paulo, SP (Brazil)

    2009-04-15

    There is a certain consensus in the literature that the earliest stage of atherogenesis is characterized by the accumulation of spongy cells in the region of the intimal artery. Risk factors such as arterial hypertension, smoking, diabetes mellitus, hypercholesterolemia, male gender and advanced age predispose a person to the formation of plaques in the coronaries and aorta. A greater number of acute coronary events as well as strokes have been observed in people with these risk factors. Strokes are the third cause of death in the USA, with about 40% of the cases being of cryptogenic origin. Since 1989 the atheroma plaques which develop in the thoracic aorta have been considered to be responsible for cerebral and peripheral strokes which were previously considered cryptogenic because imaging techniques such as electrocardiogram transesophageal, computerized tomogram, nuclear magnetic angio-resonance have visualized and characterized the lesions with plaques of arteriosclerosis in the thoracic aorta. The authors of this article made a systematic review in the PUBMED about arteriosclerosis in the aorta and its diagnostic methods. This review includes the physiopathology of the formation of atheroma to the aorta and its consequences, diagnostic methods such as echo transesophageal, computerized tomogram and angio resonance, as well as the advantages and disadvantages of each method of identification of the lesions. An analysis of the clinical significance of the size, form and location of the atheroma plaques in the thoracic aorta were made based on clinical studies, as well as their treatment with anticoagulants, antiplatelet and drugs to reduce cholesterol. (author)

  2. Respiratory Care Guide on Acute Exacerbation of Bronchial Asthma%支气管哮喘急性发作期的呼吸指导与护理

    Institute of Scientific and Technical Information of China (English)

    袁静

    2011-01-01

    目的:探讨支气管哮喘急性发作期的呼吸指导和临床护理方法.方法:对照组所有患者均采用传统护理方法,包括严密观察病情、保持呼吸道畅通、心理护理和健康教育:研究组患者在此基础上,行加强性呼吸指导和呼吸训练护理.结果:研究组患者的护理临床总有效率100%明显高于对照组96.08%,数据经统计学比较具有显著差异(P<0.05).结论:有效的呼吸指导与洲练护理,对于减少临床不良症状、提高呼吸力具有良好的疗效.%Objective: To explore effect of promoting cerebral venous return on brain function and inflammatory factor of patients with acute arteriosclerosis cerebral infarction for the reference in clinical treatment.Methods: Forty patients with acute arteriosclerosis cerebral infarction were taken as Observation Group and healthy examined people as Control Group. Observation Group was treated with thrombolysis-based therapy promoting cerebral venous return. Please observe variations in sICAM-1, sVCAM-1 and hs-CR inflammatory markers of both groups before and after treatmentResults: After therapy promoting cerebral venous return, 28 cases' brain function took a turn for the better and 12 cases not. Logistic regression analysis showed hs-CRP activity wss an independent inflammatory marker of efficacy of clinical prognosis (P<0.05). Con elusion :It improved brain function of patients with acute arteriosclerosis cerebral infarction and changed the inflammatory factor by promoting cerebral venous return. Hereinto, hs-CRP activity gave a hint at cerebral infarction to a certain degree.

  3. 高龄老年人脉压差、血脂、血糖关系分析%Analysis of the Correlation between Pulse Pressure,Blood Lipid,Blood Sugar in the Elderly People

    Institute of Scientific and Technical Information of China (English)

    丁翊; 刘芳

    2013-01-01

    Objective:Removed the age factor, to probe into the correlation between blood pressure,blood lipid,blood sugar and arteriosclerosis in the elderly people. Methods:Analyzed the correlation between Pulse Pressure,Mean Arterial blood pressure and Diabetes mellitus,Hypertension in 279 examination of the elderly. analyzed the changes of blood glucose,blood lipid at the different levels of Pulse Pressure. In order to know the correlation between Pulse Pressure,Mean Arterial blood pressure and blood glucose,blood lipid, blood pressure. Results:There was a correlation between arteriosclerosis and arterial compliance in the elderly people and hyperglycemia,the disorder of lipid metabolism and high systolic blood pressure. Conclusions:Strengthened the blood glucose management and the treatment of dyslipidemia in patients with diabetes mellitus, strengthened the control of blood pressure in patients with essential hypertension, these measures had a positive effect on prevention and treatment of senile arteriosclerosis.%目的:探讨老年动脉硬化除去年龄因素以外与血压、血糖、血脂的关系。方法:体检的老年人279例,分析脉压、平均动脉压与糖尿病、高血压病的关系及不同脉压水平下血糖、血脂的变化,进一步了解脉压、平均动脉压与血糖、血脂、血压之间的关系。结果:高龄老年人动脉硬化、血管顺应性减低与血糖增高、血脂代谢紊乱、收缩压增高有关。结论:加强糖尿病患者的血糖管理及血脂紊乱的治疗、加强高血压病患者血压控制对老年动脉硬化的防治有积极作用。

  4. Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection

    Institute of Scientific and Technical Information of China (English)

    陈勇; 窦科峰; 何勇; 孙凯

    2003-01-01

    Objective: To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis (AGA), we established a mouse aorta graft model. Methods: A segment of thoracic aortas of B10.A (2R) mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological, histochemical and electro microscopic methods. Results: Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast, the endothelial inflammation and subsequent neointimal proliferation characteristic of AGA was localized to the regions of turbulent flow, i.e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejection and neointimal formation which usually manifested together in the lesion of AGA, elucidate that different mechanisms control vascular rejection and neointimal formation in chronic rejection.

  5. Nanomaterials and nanoparticles : Sources and toxicity

    CERN Document Server

    Buzea, Cristina; Robbie, Kevin

    2008-01-01

    This review is written with the goal of informing public health concerns related to nanoscience, while raising awareness of nanomaterials toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to nanoparticles and dust from natural sources and human activities, the recent development of industry and combustion-based engine transportation profoundly increasing anthropogenic nanoparticulate pollution. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function. Among diseases associated with nanoparticles are asthma, bronchitis, lung cancer, neurodegenerative diseases (such as Parkinson`s and Alzheimer`s diseases), Crohn`s disease, colon cancer. Nanoparticles that enter the circulatory system are related to occurrence of arteriosclerosis, and blood clots, arrhythmia, heart diseases, and ultimately cardiac d...

  6. [8-year experience in 40 patients with an axillary-femoral graft].

    Science.gov (United States)

    Bialostozky, L; Rish, L; Legaspi, R; Gutiérrez Bosque, R; Archundia, A; Morales, F; Oropeza, G

    1977-01-01

    The 8 years (1967-1975) experience with axillary-femoral and femoro-femoral grafts in 40 patients is presented; 6 females and 34 males, between 50 and 90 years of age, with arteriosclerosis, all complicated by chronic illnesses. The results have been satisfactory, as the grafts are functioning from 2 months to 80 months (6 years, 8 months), most of them being more than 12 months old. Twenty eight of the 40 patients operated are alive. Four patients (10%) had infection of their grafts. In 6 (15%) the graft closed because of severe progresive distal obstruction. Three patients (7.5%) died in the first 32 post-operative days. In 9 (22.5%) the deaths were not related to surgery. The indications for placement of axillary-femoral and femoro-femoral grafts is established.

  7. Glucose Suppresses Biological Ferroelectricity in Aortic Elastin

    Science.gov (United States)

    Liu, Yuanming; Wang, Yunjie; Chow, Ming-Jay; Chen, Nataly Q.; Ma, Feiyue; Zhang, Yanhang; Li, Jiangyu

    2013-04-01

    Elastin is an intriguing extracellular matrix protein present in all connective tissues of vertebrates, rendering essential elasticity to connective tissues subjected to repeated physiological stresses. Using piezoresponse force microscopy, we show that the polarity of aortic elastin is switchable by an electrical field, which may be associated with the recently discovered biological ferroelectricity in the aorta. More interestingly, it is discovered that the switching in aortic elastin is largely suppressed by glucose treatment, which appears to freeze the internal asymmetric polar structures of elastin, making it much harder to switch, or suppressing the switching completely. Such loss of ferroelectricity could have important physiological and pathological implications from aging to arteriosclerosis that are closely related to glycation of elastin.

  8. Imaging of atherosclerosis with MRI

    International Nuclear Information System (INIS)

    Vascular delineation with Magnetic Resonance Imaging (MRI) suffers from severe artifacts caused by the motion of flowing blood. With recent developments these artifacts are reduced significantly. Using special sequences and processing algorithms the resulting images have an angiographic-like character (MR-Angiography, MRA). While MRA-signals derive from moving spins, the vessel wall itself is suppressed like it is in conventional angiography also. Prerequisites for the assessment of the arterial wall are increased spatial resolution and the discrimination of blood signals. This study demonstrates the clinical value of MRA with respect to arteriosclerosis. Moreover, a pilot study to visualize the arterial wall and atheroma is presented. (author). 11 refs.; 3 figs.; 2 tabs

  9. The significance of MR angiography for the diagnosis of carotid stenoses

    International Nuclear Information System (INIS)

    Arteriosclerosis of the supra-aortic vessels is a known risk factor for cerebrovascular disease. Large multicenter studies like NASCET and ECST have proven the protective effects of the surgical treatment of severe (>70%) carotid artery stenoses. The exact detection and grading of stenoses of the carotid arteries is a prerequisite for a successful therapy. Besides the gold-standard examination, digital subtraction angiography (DSA), MR angiography (MRA) is being used increasingly. MRA allows a non-invasive, high-resolution depiction of the supra-aortic vessels without ionizing radiation in only 20 s. This article first illustrates the MRA-techniques, and the indications and limitations of MRA. Next, the diagnostic accuracy of MRA is compared to DSA and ultrasound. The clinical value of MRA for the detection of stenoses of the carotid arteries is discussed on the basis of clinical examples. (orig.)

  10. Celiac artery stenosis/occlusion treated by interventional radiology

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, Osamu [Department of Diagnostic Radiology, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, 1-1-1, Honjo Kumamoto 860-8505 (Japan)], E-mail: osamu-3643ik@do9.enjoy.ne.jp; Tamura, Yoshitaka; Nakasone, Yutaka; Yamashita, Yasuyuki [Department of Diagnostic Radiology, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, 1-1-1, Honjo Kumamoto 860-8505 (Japan)

    2009-08-15

    Severe stenosis/occlusion of the proximal celiac trunk due to median arcuate ligament compression (MALC), arteriosclerosis, pancreatitis, tumor invasion, and celiac axis agenesis has been reported. However, clinically significant ischemic bowel disease attributable to celiac axis stenosis/occlusion appears to be rare because the superior mesenteric artery (SMA) provides for rich collateral circulation. In patients with celiac axis stenosis/occlusion, the most important and frequently encountered collateral vessels from the SMA are the pancreaticoduodenal arcades. Patients with celiac artery stenosis/occlusion are treated by interventional radiology (IR) via dilation of the pancreaticoduodenal arcade. In patients with dilation of the pancreaticoduodenal arcade on SMA angiograms, IR through this artery may be successful. Here we provide several tips on surmounting these difficulties in IR including transcatheter arterial chemoembolization for hepatocellular carcinoma, an implantable port system for hepatic arterial infusion chemotherapy to treat metastatic liver tumors, coil embolization of pancreaticoduodenal artery aneurysms, and arterial stimulation test with venous sampling for insulinomas.

  11. Paper de la 1,25 dihidroxivitamina D3 extrarenal
    en l'arteriopatia urèmica. Efecte diferencial de l'analeg 19-nor-dihidroxivitamina D2

    OpenAIRE

    Cardús Figueras, Anna

    2007-01-01

    L'arteriosclerosis és un procés caracteritzat per l'engruximent i enduriment dela paret arterial, aquest procés es troba accelerat en pacients amb insuficiència renalcrònica (IRC). A més a més, aquests pacients pateixen una disminució de la síntesisde 1,25-dihidroxivitamina D3 (1,25(OH)2D3) que comporta altres complicacions comel hiperparatïroidisme secundari (HPT2). Per aquesta raó es comú l'ús de 1,25(OH)2D3en el tractament del HPT2. L'efecte de la 1,25(OH)2D3 en la calcificació de les cèl·...

  12. Drug treatment of hyperlipidemia.

    Science.gov (United States)

    Yeshurun, D; Gotto, A M

    1976-03-01

    The most frequent indication for treatment of hyperlipidemia is for prevention of arteriosclerosis, a suspected but unproved benefit. The cornerstone of treatment of primary hyperlipidemia is diet; drugs may be added to, but do not replace, diet. When a drug is used with any patient, its potential benefits and hazards must be carefully weighed for the given subject. The subjects should be carefully followed and observed for side effects. Plasma lipids should be monitored during the course of treatment. Five drugs have been approved by the U.S. Food and Drug Administration for the treatment of hyperlipidemia: cholestyramine, clofibrate, nicotinic acid, sodium dextrothyroxine and beta-sitosterol. The use, the actions and the side effects of each and of several nonapproved agents are discussed.

  13. Non-contrast magnetic resonance angiography in renal transplantation and renal donation

    DEFF Research Database (Denmark)

    Blankholm, Anne Dorte

    2015-01-01

    Renal transplantation is the treatment of choice in cases of severe renal disease. The majority of candidates for kidney transplantation have arteriosclerosis to some extent; thus, preoperative imaging of the vessels is needed. Different imaging modalities are available and are used...... renal transplantation. In 2006, it was realised that the Gd used in CEMRA could cause NSF, which prompted the Danish National Board of Health to produce guidelines for the use of contrast agents in patients with severe renal disease. This thesis discusses different preoperative imaging methods without...... contrast agents before kidney transplantation and kidney donation. Study I is a review of NCMRA techniques and clinical applications. In study II, we searched for an NCMRA method with consistently good image quality for the examination of the pelvic vessels in patients with severe renal disease. Five...

  14. Review article: Getting the balance right: assessing causes and extent of vascular calcification in chronic kidney disease.

    Science.gov (United States)

    Ketteler, Markus; Biggar, Patrick H

    2009-06-01

    Vascular calcification is part of the definition of chronic kidney disease-mineral and bone disorder (CKD-MBD). It is also a surrogate parameter of cardiovascular and all-cause mortality risk in the CKD population. However, vascular calcification is not a homogenous entity, but a rather complex manifestation influenced by derangements of calcium and phosphate homeostasis, by dysregulated calcification inhibitors and promoters, and by the type of arterial disease (atherosclerosis vs arteriosclerosis). Despite the clear-cut risk association between the presence of vascular calcification and mortality, it is currently not well defined, how this knowledge about calcification should be translated into active clinical management. Further, the choice of the appropriate imaging test is a matter of debate. This article attempts to provide an update on insights into the pathophysiology of vascular calcification processes and a subjective view of the clinical consequences of management of CKD patients at risk. PMID:19563380

  15. Diabetes mellitus in a black-footed ferret

    Science.gov (United States)

    Carpenter, J.W.; Novilla, M.N.

    1977-01-01

    Diabetes mellitus was tentatively diagnosed in a black-footed ferret with polyuria, polydipsia, polyphagia, dehydration, and weight loss. Laboratory findings (marked hyperglycemia (724 mg/100 ml), glycosuria, and ketonuria) and the subsequent favorable response to insulin therapy confirmed the diagnosis. Although lesions were not observed in the pancreas, gross and histologic findings concomitant with diabetes mellitus included arteriosclerosis, with calcification of the aorta and other major vessels; mild necrotizing hepatitis; and mild proliferative glomerulonephritis. A perineal adenocarcinoma, with metastasis to an internal iliac lymph node, was an incidental finding. Special stains demonstrated adequate numbers of beta cell granules in the islets of Langerhans. Thus, the diabetes was apparently due to a lack of release of the synthesized insulin or to diminished effectiveness of the secreted insulin.

  16. Probabilistic retinal vessel segmentation

    Science.gov (United States)

    Wu, Chang-Hua; Agam, Gady

    2007-03-01

    Optic fundus assessment is widely used for diagnosing vascular and non-vascular pathology. Inspection of the retinal vasculature may reveal hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. Due to various imaging conditions retinal images may be degraded. Consequently, the enhancement of such images and vessels in them is an important task with direct clinical applications. We propose a novel technique for vessel enhancement in retinal images that is capable of enhancing vessel junctions in addition to linear vessel segments. This is an extension of vessel filters we have previously developed for vessel enhancement in thoracic CT scans. The proposed approach is based on probabilistic models which can discern vessels and junctions. Evaluation shows the proposed filter is better than several known techniques and is comparable to the state of the art when evaluated on a standard dataset. A ridge-based vessel tracking process is applied on the enhanced image to demonstrate the effectiveness of the enhancement filter.

  17. C-Peptide and Atherogenesis: C-Peptide as a Mediator of Lesion Development in Patients with Type 2 Diabetes Mellitus?

    Directory of Open Access Journals (Sweden)

    Nikolaus Marx

    2008-01-01

    Full Text Available Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show increased levels of C-peptide and over the last years various groups examined the effect of C-peptide in vascular cells as well as its potential role in lesion development. While some studies demonstrated beneficial effects of C-peptide, for example, by showing an inhibition of smooth muscle cell proliferation, others suggested proatherogenic mechanisms in patients with type 2 diabetes. Among them, C-peptide may facilitate the recruitment of inflammatory cells into early lesions and promote lesion progression by inducing smooth muscle cell proliferation. The following review will summarize the effects of C-peptide in vascular cells and discuss the potential role of C-peptide in atherogenesis in patients with type 2 diabetes.

  18. Laser angioplasty for cardiovascular disease

    Science.gov (United States)

    Okada, Masayoshi

    2005-07-01

    Recently, endovascular interventions such as balloon angioplasty, atherectomy and the stenting method, except for conventional surgery have been clinically employed for the patients with atheromatous plaques of the peripheral- and the coronary arteries, because the number of patients with arteriosclerosis is now increasing in the worldwide. Among these procedures, restenoses after endovascular interventions have been remarkably disclosed in 20-40 % of the patients who underwent percutaneous coronary interventions. Thus, there are still some problems in keeping long-term patency by means of endovascular techniques such as balloon angioplasty and atherectomy (1, 2). For reduction of these problems , laser angioplasty using Argon laser was applied experimentally and clinically. Based on excellent experimental studies, laser was employed for 115 patients with stenotic ,or obstructive lesions occluding more thasn 75 % of the peripheral and the coronary arteries angiographycally.

  19. Estimation of Stiffness Parameter on the Common Carotid Artery

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao; Matsui, Kiyoaki; Nakamura, Takashi

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. Up to the present, several methods to measure stiffness parameter of the carotid artery have been proposed. However, they have analyzed at the only one point of common carotid artery. In this paper, we propose the method of analysis extended over a wide area of common carotid artery. In order to measure stiffness parameter of common carotid artery from echocardiogram, it is required to detect two border curves which are boundaries between vessel wall and blood. The method is composed of two steps. The first step is the detection of border curves, and the second step is the calculation of stiffness parameter using diameter of common carotid artery. Experimental results show the validity of the proposed method.

  20. Adaptive Estimation of Intravascular Shear Rate Based on Parameter Optimization

    Science.gov (United States)

    Nitta, Naotaka; Takeda, Naoto

    2008-05-01

    The relationships between the intravascular wall shear stress, controlled by flow dynamics, and the progress of arteriosclerosis plaque have been clarified by various studies. Since the shear stress is determined by the viscosity coefficient and shear rate, both factors must be estimated accurately. In this paper, an adaptive method for improving the accuracy of quantitative shear rate estimation was investigated. First, the parameter dependence of the estimated shear rate was investigated in terms of the differential window width and the number of averaged velocity profiles based on simulation and experimental data, and then the shear rate calculation was optimized. The optimized result revealed that the proposed adaptive method of shear rate estimation was effective for improving the accuracy of shear rate calculation.

  1. Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

    Directory of Open Access Journals (Sweden)

    Amanda E Boe

    Full Text Available Nω-nitro-L-arginine methyl ester (L-NAME treatment induces arteriosclerosis and vascular senescence. Here, we report that the systemic inhibition of nitric oxide (NO production by L-NAME causes pulmonary emphysema. L-NAME-treated lungs exhibited both the structural (alveolar tissue destruction and functional (increased compliance and reduced elastance characteristics of emphysema development. Furthermore, we found that L-NAME-induced emphysema could be attenuated through both genetic deficiency and pharmacological inhibition of plasminogen activator inhibitor-1 (PAI-1. Because PAI-1 is an important contributor to the development of senescence both in vitro and in vivo, we investigated whether L-NAME-induced senescence led to the observed emphysematous changes. We found that L-NAME treatment was associated with molecular and cellular evidence of premature senescence in mice, and that PAI-1 inhibition attenuated these increases. These findings indicate that NO serves to protect and defend lung tissue from physiological aging.

  2. Estimation of Arterial Stiffness by Time-Frequency Analysis of Pulse Wave

    Science.gov (United States)

    Saito, Masashi; Yamamoto, Yuya; Shibayama, Yuka; Matsukawa, Mami; Watanabe, Yoshiaki; Furuya, Mio; Asada, Takaaki

    2011-07-01

    Evaluation of a pulse wave is effective for the early diagnosis of arteriosclerosis because the pulse wave contains the reflected wave that is the age- and stiffness-dependent component. In this study, we attempted to extract the parameter reflecting the component by pulse wave analysis using continuous wavelet transform. The Morlet wavelet was used as the mother wavelet. We then investigated the relationship between the parameter and the reflected wave that was extracted from the pulse wave by our previously reported separation technique. Consequently, the result of wavelet transform of the differentiated pulse waveform changed markedly owing to age and had medium correlation with the peak of the reflected wave (R=0.68).

  3. Genetic Susceptibility to Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Sanja Kovacic

    2012-01-01

    Full Text Available Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.

  4. Development of a Mechanical Scanning-type Intravascular Ultrasound System Using a Miniature Ultrasound Motor

    Science.gov (United States)

    Tanabe, Masayuki; Xie, Shangping; Tagawa, Norio; Moriya, Tadashi; Furukawa, Yuji

    2007-07-01

    Intravascular ultrasound (IVUS) plays an important role for the detection of arteriosclerosis, which causes the ischemic heart disease. In mechanical scanning-type IVUS, it is necessary to rotate a transducer or a reflecting mirror. A method that involves rotating the transducer using a torque wire causes image distortion (NURD: non uniform rotation distortion). For a method that involves placing an electromagnetic motor on the tip of an IVUS probe is difficult to miniaturize the probe. Our objectives are to miniaturize the probe (1 mm in diameter, 5 mm in length) and to remove NURD. Therefore, we conducted a study to assess the feasibility of attaining these objectives by constructing a prototype IVUS system, in which an ultrasound motor using a stator in the form of a helical coil (abbreviated as CS-USM: coiled stator-ultrasonic motor) is incorporated, and to clarify problems that need to be solved in constructing the probe.

  5. Ultrasonic Measurement of Fluid Viscosity for Blood Characterization

    Science.gov (United States)

    Nitta, Naotaka; Homma, Kazuhiro

    2005-06-01

    Although plaque rupture in arteriosclerosis is affected by not only its strength but also by hemodynamic factors, such as blood pressure and shear stress, in particular, the viscous coefficient which directly controls the magnitude of shear stress might be a risk factor in plaque rupture. Therefore, if the viscous coefficient can be assessed noninvasively, it can be a useful index for prediction of a plaque rupture and assessment of various diseases. In this work, an ultrasonic methodology to estimate the viscous coefficient was investigated by numerical simulation and flow-phantom experiment as the fundamental investigation for noninvasively assessing the viscous characteristics of blood. These results show that the proposed method is useful for estimating the kinematic viscosity coefficient in the viscous evaluation of blood.

  6. Medical and biological applications for ultrafast laser pulses

    Science.gov (United States)

    Lubatschowski, Holger; Heisterkamp, Alexander; Will, Fabian; Singh, Ajoy I.; Serbin, Jesper; Ostendorf, Andreas; Kermani, Omid; Heermann, R.; Welling, Herbert; Ertmer, Wolfgang

    2003-02-01

    Due to the low energy threshold of photodisruption with fs laser pulses, thermal and mechanical side effects are limited to the sub μm range. The neglection of side effects enables the use of ultrashort laser pulses in a broad field of medical applications. Moreover, the interaction process based on nonlinear absorption offers the opportunity to process transparent tissue three dimensionally inside the bulk. We demonstrate the feasibility of surgical procedures in different fields of medical interest: In ophthalmology intrastromal cutting and preparing of corneal flaps for refractive surgery in living animals is presented. Besides, the very low mechanical side effects enables the use of fs-laser in otoralyngology to treat ocecular bones. Moreover, the precise cutting quality can be used in fields of cardiovascular surgery for the treatment of arteriosclerosis as well as in dentistry to remove caries from dental hard tissue.

  7. Compliant Wall Simulation of a Healthy Carotid Bifurcation

    Science.gov (United States)

    Williamson, Shobha; Rayz, Vitaliy; Saloner, David; Berger, Stanley

    2003-11-01

    Cardiovascular disease is a major cause of mortality in the industrialized world. Together with the genetic causes of this disease, fluid-structure interaction (FSI) in the arterial system plays a role in the development of arteriosclerosis. In an effort to further understand this disease, an FSI model of the carotid artery is in progress. To construct this model, we begin with compliant arterial wall deformation considered under transient global blood pressure. Vessel walls are composed of collagen fibers, elastin, smooth muscle, and water. Due to its complexity and variation among humans, it is difficult to create an accurate mechanical description of this material. Hence, we begin by way of isotropic properties with the future intent of anisotropic modeling. Using these parameters, a pulsatile 3D model of wall movement for a healthy carotid artery is presented. Supported under a National Science Foundation Graduate Research Fellowship, NIH Grant HL61823, and PBD, Inc.

  8. Architectural Analyses and Developments of 1 mm Diameter Micro Forceps for Catheter Surgery

    Science.gov (United States)

    Nokata, Makoto; Hashimoto, Yusuke; Obayashi, Takumi

    Blockage in a blood vessel due to cardiovascular disease such as arteriosclerosis or aneurysms requires minimally invasive placement of a mesh tube or platinum coil stent via a catheter to open the affected area. Stents are positioned using a guide wire via a catheter, but the stent may be dropped on the way to its destination and requires much time in surgery, increasing the burden on the patient. Medical apparatuses are thus desired having a mechanism to grasp artifacts securely in blood vessels. We designed prototype microforceps for use on the end of a catheter for grasping operation in blood vessels and to contribute to medical apparatuses in this field. The microforceps we designed using a minimum number of parts uses metal injection molding (MIM) to realize strong mass production. Microforceps installed in the tip of a catheter. Stress analysis verified its capability to grasp, bend and turn within the confines of a blood vessels model.

  9. Non-contact measurement of pulse wave velocity using RGB cameras

    Science.gov (United States)

    Nakano, Kazuya; Aoki, Yuta; Satoh, Ryota; Hoshi, Akira; Suzuki, Hiroyuki; Nishidate, Izumi

    2016-03-01

    Non-contact measurement of pulse wave velocity (PWV) using red, green, and blue (RGB) digital color images is proposed. Generally, PWV is used as the index of arteriosclerosis. In our method, changes in blood volume are calculated based on changes in the color information, and is estimated by combining multiple regression analysis (MRA) with a Monte Carlo simulation (MCS) model of the transit of light in human skin. After two pulse waves of human skins were measured using RGB cameras, and the PWV was calculated from the difference of the pulse transit time and the distance between two measurement points. The measured forehead-finger PWV (ffPWV) was on the order of m/s and became faster as the values of vital signs raised. These results demonstrated the feasibility of this method.

  10. Pressure Gradient Estimation Based on Ultrasonic Blood Flow Measurement

    Science.gov (United States)

    Nitta, Naotaka; Homma, Kazuhiro; Shiina, Tsuyoshi

    2006-05-01

    Mechanical load to the blood vessel wall, such as shear stress and pressure, which occurs in blood flow dynamics, contribute greatly to plaque rupture in arteriosclerosis and to biochemical activation of endothelial cells. Therefore, noninvasive estimations of these mechanical loads are able to provide useful information for the prevention of vascular diseases. Although the pressure is the dominant component of mechanical load, for practical purposes, the pressure gradient is also often important. So far, we have investigated the estimation of the kinematic viscosity coefficient using a combination of the Navier-Stokes equations and ultrasonic velocity measurement. In this paper, a method for pressure gradient estimation using the estimated kinematic viscosity coefficient is proposed. The validity of the proposed method was investigated on the basis of the analysis with the data obtained by computer simulation and a flow phantom experiment. These results revealed that the proposed method can provide a valid estimation of the pressure gradient.

  11. Regional calcium distribution and ultrasound images of the vessel wall in human carotid arteries

    Science.gov (United States)

    Szikszai, Z.; Kertész, Zs.; Uzonyi, I.; Szíki, G. Á.; Magyar, M. T.; Molnár, S.; Ida, Y.; Csiba, L.

    2005-04-01

    Arterial calcification can take place at two sites in the vessel wall: the intima and the media. Intimal calcification occurs exclusively within atherosclerotic plaques, while medial calcification may develop independently. Extensive calcified plaques in the carotid arteries can be easily detected by B-mode ultrasonic imaging. The calcium content might correlate with the ultrasound reflectance of the vessel wall, and could be a surrogate marker for arteriosclerosis. In this study, segments of human carotid arteries collected at autopsy were examined by ultrasonography in vitro and calcium distributional maps of sections from the same segments were determined by particle induced X-ray emission. Our aim was to make a first step towards investigating the relationship between the calcium distributional maps and the respective ultrasound images.

  12. Modulation of the sis Gene Transcript during Endothelial Cell Differentiation in vitro

    Science.gov (United States)

    Jaye, Michael; McConathy, Evelyn; Drohan, William; Tong, Benton; Deuel, Thomas; Maciag, Thomas

    1985-05-01

    Endothelial cells, which line the interior walls of blood vessels, proliferate at the site of blood vessel injury. Knowledge of the factors that control the proliferation of these cells would help elucidate the role of endothelial cells in wound healing, tumor growth, and arteriosclerosis. In vitro, endothelial cells organize into viable, three-dimensional tubular structures in environments that limit cell proliferation. The process of endothelial cell organization was found to result in decreased levels of the sis messenger RNA transcript and increased levels of the messenger RNA transcript for fibronectin. This situation was reversed on transition from the organized structure to a proliferative monolayer. These results suggest a reciprocity for two biological response modifiers involved in the regulation of endothelial cell proliferation and differentiation in vitro.

  13. Replicating Cardiovascular Condition-Birth Month Associations

    Science.gov (United States)

    Li, Li; Boland, Mary Regina; Miotto, Riccardo; Tatonetti, Nicholas P.; Dudley, Joel T.

    2016-01-01

    Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms. PMID:27624541

  14. Flexible pulse-wave sensors from oriented aluminum nitride nanocolumns

    Science.gov (United States)

    Akiyama, Morito; Ueno, Naohiro; Nonaka, Kazuhiro; Tateyama, Hiroshi

    2003-03-01

    Flexible pulse-wave sensors were fabricated from density-packed oriented aluminum nitride nanocolumns prepared on aluminum foils. The nanocolumns were prepared by the rf magnetron sputtering method and were perpendicularly oriented to the aluminum foil surfaces. The sensor structure is laminated, and the structure contributes to avoiding unexpected leakage of an electric charge. The resulting sensor thickness is 50 μm. The sensor is flexible like aluminum foil and can respond to frequencies from 0.1 to over 100 Hz. The sensitivity of the sensor to pressure is proportional to the surface area. The sensor sensitively causes reversible charge signals that correlate with the pulse wave form, which contains significant information on arteriosclerosis and cardiopathy of a man sitting on it.

  15. Chronic Kidney Isograft and Allograft Rejection

    Institute of Scientific and Technical Information of China (English)

    严群; 张鹏; 杨传永

    2002-01-01

    Summary: In this study antigen-independent factor in the pathogenesis of chronic rejection of organ transplants was examined. Kidney isografts and allografts were transplanted orthotopically into bilaterally nephroectomized rat recipients and studied functionally, morphologically and immunohistologically, at serial intervals up to 52 weeks after transplantation. Allograft recipients developed progressive proteinuria after 12 weeks, with gradual renal failure ultimately leading to death. At the same time, morphological changes, including progressive arteriosclerosis and glomerulosclerosis, tubular atrophy and interstitial fibrosis, developed. Immunohistologically, macrophages infiltrated glomeruli during this period and cytokines became unregulated. Our resuits showed that antigen-independent functional and morphological changes occurred in long-term kidney isografts and mimicked those appearing much earlier in allografts that reject chronically.Initial injury and extent of functioning renal mass is suggested to be important factor for such late changes.

  16. Water hardness in relation to cadium accumulation and microscopic signs of cardiovascular disease in horses.

    Science.gov (United States)

    Elinder, C G; Jonsson, L; Sternström, T; Piscator, M; Linnman, L

    1980-01-01

    The hardness of drinking water (i.e., the sum of calcium and magnesium concentrations) has been related to cadmium concentration in kidney cortex and to microscopic signs of arteriosclerosis and focal myocardial fibrosis in 50 Swedish horses slaughtered for meat production. A significant negative correlation was found between water hardness and cadmium concentrations in kidney cortex. This indicates that horses living in soft water areas are more inclined to accumulate cadmium from the general environment. Microscopic changes in the aorta and myocardium were approximately 2 times as frequent in horses that drank soft water compared to horses that drank hard water. The differences were, however, not statistically significant. It is concluded that horses are well suited for studies of the "water factor". PMID:7369796

  17. PATHOMORPHOLOGY OF ZERO BIOPSIES OF DONOR KIDNEYS

    Directory of Open Access Journals (Sweden)

    M. L. Arefjev

    2011-01-01

    Full Text Available There is well known fact that kidney transplants from Extended Criteria Donors may increase risk of De- layed Graft Function and Primary Non-Function of transplants. We have collected and tested 65 «zero» kidney biopsies from cadaver donors aged from 19 to 71 years old. In the pool of elderly donors who died from cerebrovascular accident the frequency of nephrosclerosis presentation was higher than in donors of yonger age who died from craniocephalic trauma. Nevertheless in the general donor pool the number of sclerosed glomeruli was no more than 12%. We did not meet at all in the whole volume of material any bi- opsy with the severe degree of arteriosclerosis. The «zero» biopsies of cadaver kidneys is quite usable and unexpensive tool to measure the degree of nephrosclerosis in order to exclude kidneys which are not fitable for transplantation. 

  18. Interventional therapy of huge aneurysm

    International Nuclear Information System (INIS)

    Objective: To evaluate the methods and the efficacy of interventional therapy for huge aneurysm. Methods: Seven patients with huge aneurysm including 2 with pulmonary aneurysm, 2 with renal aneurysm, 1 with humeral artery aneurysm, 1 with right common iliac artery aneurysm, 1 with right internal iliac artery aneurysm. Among these, 5 were true aneurysm, and 2 were pseudoaneurysms caused by congenital, trauma, arteriosclerosis. Three patients were treated with endovascular covered stent graft and 2 patients with embolization containing metallic coils. Two patients were treated with partial aneurysm and feeding artery trunk embolization with metallic coils. Results: All 7 patients were successful carried out the interventional therapy with successful rate of 100%. Six aneurysms were completely obstructed with disappearance of symptoms and signs. One died of aneurysm rupture. No other complication occurred. Conclusion: Interventional therapy for huge aneurysm is an effective method. (authors)

  19. Mediastinal radiotherapy and ostial lesion of the left main coronary artery; Radioterapia mediastinica e lesao ostial de tronco de coronaria esquerda

    Energy Technology Data Exchange (ETDEWEB)

    Victor, Edgar Guimaraes; Parente, Giordano Bruno de Oliveira [Pernambuco Univ., Recife, PE (Brazil). Hospital das Clinicas]. E-mail: evictor@truenet.com.br

    2004-03-01

    Ischemic cardiac disease is a rare complication and, only recently recognized, of mediastinal irradiation for neoplasms in this region. A case of a 51 years old woman with angina pectoris, rapidly progressive is related, where the angiographic finding was represented by ostial sub occlusive lesion of the left coronary body. The previous story showed the use of radiotherapy for mediastinal Hodgkin lymphoma treatment, with close relation to right ventricle, removed by surgery and afterwards treated with irradiation and chemotherapy two years ago. The coronary stenosis induction in these patients can be dependent or not of the focal arteriosclerosis and is mediated, mainly, by intimal thickness due to tissular fibrosis without alteration in the medium layer and with inclination for the ostial portions of the main arteries. The recognition of this condition (thorax radiotherapy), as an isolated and independent factor for the coronary disease, should be considered in the acting plan for prevention, detection and previous therapy.

  20. Celiac artery stenosis/occlusion treated by interventional radiology

    International Nuclear Information System (INIS)

    Severe stenosis/occlusion of the proximal celiac trunk due to median arcuate ligament compression (MALC), arteriosclerosis, pancreatitis, tumor invasion, and celiac axis agenesis has been reported. However, clinically significant ischemic bowel disease attributable to celiac axis stenosis/occlusion appears to be rare because the superior mesenteric artery (SMA) provides for rich collateral circulation. In patients with celiac axis stenosis/occlusion, the most important and frequently encountered collateral vessels from the SMA are the pancreaticoduodenal arcades. Patients with celiac artery stenosis/occlusion are treated by interventional radiology (IR) via dilation of the pancreaticoduodenal arcade. In patients with dilation of the pancreaticoduodenal arcade on SMA angiograms, IR through this artery may be successful. Here we provide several tips on surmounting these difficulties in IR including transcatheter arterial chemoembolization for hepatocellular carcinoma, an implantable port system for hepatic arterial infusion chemotherapy to treat metastatic liver tumors, coil embolization of pancreaticoduodenal artery aneurysms, and arterial stimulation test with venous sampling for insulinomas.

  1. Bilateral quadriceps tendon rupture: a rare finding in a healthy man after minimal trauma.

    Science.gov (United States)

    Chiu, Michael; Forman, Edward S

    2010-03-01

    Quadriceps tendon rupture is an uncommon injury; the incidence of simultaneous bilateral quadriceps tendon rupture is extremely rare. Two distinct categories-individuals older than 50 years and between 27 and 54 years-have been described. Bilateral quadriceps tendon rupture is more common in patients older than 50 years and is thought to be the result of tendon weakening due to obesity and arteriosclerosis-induced fibrotic changes, or previous injury.In younger individuals, bilateral simultaneous quadriceps rupture is less frequent and has been associated with anabolic steroid use, but more frequently with underlying comorbid medical conditions such as chronic renal failure, hyperparathyroidism, endocrine disorder, gout, diabetes and obesity, which predispose the patients to tendon rupture. Our case report is unique because we report the simultaneous bilateral quadriceps tendon rupture following minor trauma in an otherwise healthy 43-year-old man with no predisposing comorbidity.

  2. Ultrasonographic diagnosis of an endocarditis valvularis in a Burmese python (Python molurus bivittatus) with pneumonia.

    Science.gov (United States)

    Schroff, Sandra; Schmidt, Volker; Kiefer, Ingmar; Krautwald-Junghanns, Maria-Elisabeth; Pees, Michael

    2010-12-01

    An 11-yr-old Burmese python (Python molurus bivittatus) was presented with a history of respiratory symptoms. Computed tomography and an endoscopic examination of the left lung were performed and revealed severe pneumonia. Microbiologic examination of a tracheal wash sample and an endoscopy-guided sample from the lung confirmed infection with Salmonella enterica ssp. IV, Enterobacter cloacae, and Klebsiella pneumoniae. Computed tomographic examination demonstrated a hyperattenuated structure within the heart. Echocardiographic examination revealed a hyperechoic mass at the pulmonic valve as well as a dilated truncus pulmonalis. As therapy for pneumonia was ineffective, the snake was euthanized. Postmortem examination confirmed pneumonia and infective endocarditis of the pulmonic valve caused by septicemia with Salmonella enterica ssp. IV. Focal arteriosclerosis of the pulmonary trunk was also diagnosed. The case presented here demonstrates the possible connection between respiratory and cardiovascular diseases in snakes.

  3. Aging and calcium as an environmental factor.

    Science.gov (United States)

    Fujita, T

    1985-12-01

    Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age. Low calcium and vitamin D intake, short solar exposure, decreased intestinal absorption, and falling renal function with insufficient 1,25(OH)2 vitamin D biosynthesis all contribute to calcium deficiency, secondary hyperparathyroidism, bone loss and possibly calcium shift from the bone to soft tissue, and from the extracellular to the intracellular compartment, blunting the sharp concentration gap between these compartments. The consequences of calcium deficiency might thus include not only osteoporosis, but also arteriosclerosis and hypertension due to the increase of calcium in the vascular wall, amyotrophic lateral sclerosis and senile dementia due to calcium deposition in the central nervous system, and a decrease in cellular function, because of blunting of the difference in extracellular-intracellular calcium, leading to diabetes mellitus, immune deficiency and others (Fig. 6). PMID:2943880

  4. A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

    DEFF Research Database (Denmark)

    Bendtzen, Klaus; Christensen, Ole; Nielsen, Claus Henrik;

    2014-01-01

    When exposed to small amounts of bacterial endotoxin, matrices of cholesterol crystals, but not cholesterol itself, primed human monocytes/macrophages to a highly augmented (>10-fold) production of inflammatory tumor necrosis factor-α. Priming also sensitized the cells, as 10- to 100-fold lower...... levels of endotoxin were needed for TNF-α production equivalent to that of unprimed cells. The pro-inflammatory effect was selective as endotoxin-induced production of other pro-inflammatory cytokines was unaffected while production of anti-inflammatory interleukin-10 was diminished. These findings...... suggest that cholesterol matrix formation may play a pathogenic role in atherosclerotic inflammation, and they indicate a mechanism by which bacteria and/or bacterial products may play a role in processes leading to arteriosclerosis....

  5. Quantitative and semi-quantitative histopathological examination of renal biopsies in healthy individuals, and associations with kidney function.

    Science.gov (United States)

    Bar, Yael; Barregard, Lars; Sallsten, Gerd; Wallin, Maria; Mölne, Johan

    2016-05-01

    This study assesed the prevalence of histopathological changes in renal biopsies from healthy individuals, and the association with age, sex and smoking. Donor biopsies from 109 subjects were obtained from living kidney donors, and blood and urine samples were collected together with medical history. All biopsies were scored according to the Banff '97 classification with some modifications. The parameters included in this study were tubular atrophy, interstitial fibrosis, glomerulosclerosis, arteriosclerosis, arteriolohyalinosis and a sclerosis score. An alternative scoring system for tubular atrophy was examined (using ≤5% rather than kidney donors around 50 years of age with normal kidney function. We propose that a cut-off of ≤5% yields a better definition of grade 0 tubular atrophy compared with the established cut-off of >0%.

  6. Homocysteine and the pathogenesis of atherosclerosis.

    Science.gov (United States)

    McCully, Kilmer S

    2015-03-01

    The homocysteine theory of arteriosclerosis was discovered by study of arteriosclerotic plaques occurring in homocystinuria, a disease caused by deficiencies of cystathionine synthase, methionine synthase or methylenetetrahydrofolate reductase. According to the homocysteine theory, metabolic and nutritional abnormalities leading to elevation of plasma homocysteine cause atherosclerosis in the general population without these rare enzymatic abnormalities. Through studies of metabolism of homocysteine thiolactone, the anhydride of homocysteine, in cell cultures from homocystinuric children, the pathway for synthesis of sulfate was found to be dependent upon thioretinamide, the amide formed from retinoic acid and homocysteine thiolactone. Two molecules of thioretinamide form the complex thioretinaco with cobalamin, and oxidative phosphorylation is catalyzed by reduction of oxygen, which is bound to thioretinaco ozonide, by electrons from electron transport particles. Atherogenesis is attributed to formation of aggregates of homocysteinylated lipoproteins with microorganisms, which obstruct the vasa vasorum during formation of arterial vulnerable plaques. PMID:25653125

  7. Green tea polyphenol (-)-epigallocatechin gallate suppressed the differentiation of murine osteoblastic MC3T3-E1 cells.

    Science.gov (United States)

    Kamon, Masayoshi; Zhao, Ran; Sakamoto, Kazuichi

    2009-12-16

    Recently, various physiological effects of the tea polyphenol catechin for alleviating diseases such as cancer, arteriosclerosis, hyperlipidaemia and osteoporosis have been reported. However, the physiological effect of catechin on bone metabolism remains unclear. We examined the physiological effect of EGCG [(-)-epigallocatechin-3-gallate], which is the main component of green tea catechin, on osteoblast development using the precursor cell line of osteoblasts, MC3T3-E1, and co-culture of the osteoblasts from mouse newborn calvaria and mouse bone marrow cells. Although EGCG did not affect the viability and proliferation of MC3T3-E1 cells, EGCG inhibited the osteoblast differentiation. Furthermore, EGCG did not affect the mineralization of differentiated MC3T3-E1 cells, and reduced osteoclast formation in co-culture. These results suggest that EGCG can effectively suppress bone resorption, and can be used as an effective medicine in the treatment of the symptoms of osteoporosis.

  8. Renal histology in two adult patients with type I glycogen storage disease.

    Science.gov (United States)

    Obara, K; Saito, T; Sato, H; Ogawa, M; Igarashi, Y; Yoshinaga, K

    1993-02-01

    Two adult patients with type I glycogen storage disease (I-GSD) had chronic renal disease with heavy proteinuria. Renal biopsies showed focal glomerular sclerosis, interstitial fibrosis, tubular atrophy or vacuolation, and prominent arteriosclerosis. Marked glomerular hypertrophy was demonstrated histometrically. Oil red O staining in one patient revealed numerous lipid deposits in the glomerular mesangium, tubular epithelial cells and interstitium. Electron microscopy in the other patient revealed diffuse thickening of the glomerular basement membrane (GBM) and lipid droplets within the mesangium. The glomerular hypertrophy, thickening of the GBM, and subsequent sclerosis were similar to those in insulin-dependent diabetes mellitus. These findings may explain the similarities between the natural histories of renal involvement in the two disorders. Particularly, glomerular hypertrophy may be a key step leading to glomerular sclerosis, which is the predominant finding I-GSD. Hyperlipidemia, which is commonly seen in I-GSD, may also accelerate the glomerular sclerosing process.

  9. Study the active site of flavonoid applying radiation chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Wu Jilan; Sun Gang; Zhang Fugen; He Yongke; Li Jiuqiang [Department of Technical Physics, Peking Univ., Beijing (China)

    2000-03-01

    Flavonoid are a large and important class of naturally occurring, low molecular weight benzo-{gamma}-pyrone derivatives which are reported to have a myriad of biological activities, but the study on the active sites of flavonoids is still ambiguous. In this paper, rutin, quercetin and baicalin have been selected as model compounds. It is well known that rutin is used in inhibiting arteriosclerosis and baicalin is antibacterial and antiviral. They have similar basic structure, but their medicinal properties are so different, why? As most flavonoids contain carbonyl group, which can capture electron effectively, we predict that flavonoids can capture electron to form radical anion. The formation of anion radical may have influence on the mitochondrial electron transport chain. The difference in the ability of forming anion radical may cause the difference in their medicinal effects. (author)

  10. [Raynaud's phenomenon and other circulatory disorders of the fingers].

    Science.gov (United States)

    Mahler, Felix

    2014-02-26

    Raynaud's phenomenon (RP) is defined as attacks of blanking, subsequent cyanosis and rubeosis of fingers due to vasospasms in response to cold or emotional stimuli. Primary RP has no known underlying cause and occurs mainly in young and otherwise healthy women. Secondary RP goes along with various causes such as connective tissue diseases, toxic substances, drugs, physical trauma or organic finger artery occlusions, and occurs at any age and in both genders. Related affections are acrocyanosis and finger artery occlusions either due to arteriosclerosis or vasculitis. Also spontaneous finger hematoma may provoke an episode of RP. Therapeutically strict cold protection and avoidance of possible noxa is recommended besides the treatment of underlying diseases. No standard vasoactive drug has proven ideal for RP due to side effects. In cases with rest pain or ulcerations the same principles are applied as in ischemic diseases with no possibility for revascularization.

  11. Acute arterial occlusion in the midpiece of femoral artery following total knee arthroplasty: Report of one case

    Institute of Scientific and Technical Information of China (English)

    Rui He; Liu Yang

    2016-01-01

    Acute arterial occlusion is a rare complication following total knee arthroplasty (TKA).The incidence as reported previously is from 0.03% to 0.17%;however,the sequelae can be disastrous because of its potential threat to limb loss.We report a case of acute arterial occlusion in the midpiece of femoral artery following TKA occurred 40 min postoperatively.The occlusion site existed at the midpiece of femoral artery is uncommon.Arterial circulation of the lower limb could not be restored by the thrombolysis and thrombectomy treatments performed within 11 h after TKA.In the end,amputation had to be carried out.In the treatment of acute arterial occlusion following TKA with a tourniquet,it is important to fully consider that arteriosclerosis may induce atheromatous plaque disruption,which might be the reason for acute arterial occlusion.

  12. Arterial Stiffness in Patients Taking Second-generation Antipsychotics

    Science.gov (United States)

    Fındıklı, Ebru; Gökçe, Mustafa; Nacitarhan, Vedat; Camkurt, Mehmet Akif; Fındıklı, Hüseyin Avni; Kardaş, Selçuk; Şahin, Merve Coşgun; Karaaslan, Mehmet Fatih

    2016-01-01

    Objective That treatment with second-generation antipsychotics (SGAs) causes metabolic side effects and atherosclerosis in patients with schizophrenia and bipolar disorder (BD) is well-known. Increased arterial stiffness is an important marker of arteriosclerosis and has been identified as an independent risk factor for cardiovascular diseases. We measured pulse wave velocity (PWV) as a marker of arteriosclerosis in patients with schizophrenia and BD who use SGAs. Methods Patients and controls were collected from our psychiatry outpatient clinics or family medicine. Mental illness was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Mean age, gender, systolic and diastolic blood pressure, body mass index, Framingham risk score (FRS), etc. were determined. Simultaneous electrocardiography and pulse wave were recorded with an electromyography device. The photo-plethysmographic method was used to record the pulse wave. Inclusion criteria included use of SGAs for at least the last six months. Patients with diseases that are known to cause stiffness and the use of typical antipsychotics were excluded. Results Ninety-six subject (56 patients, 40 controls) were included in our study. There were 49 females, 47 males. Patients had schizophrenia (n=17) and BD (n=39). Their treatments were quetiapine (n=15), risperidone (n=13), olanzapine (n=15), and aripiprazole (n=13). Although differences in mean age, gender, and FRS in the patient and control groups were not statistically significant (p=1), PWV was greater in patients in the antipsychotic group (p=0.048). Conclusion This study supported the liability to stiffness in patients with schizophrenia and BD. Using SGAs may contribute to arterial stiffness in these patients. PMID:27776389

  13. Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit?

    Science.gov (United States)

    Guerrot, Dominique; François, Arnaud; Boffa, Jean-Jacques; Boulos, Nada; Hanoy, Melanie; Legallicier, Bruno; Triquenot-Bagan, Aude; Guyant-Marechal, Lucie; Laquerriere, Annie; Freguin-Bouilland, Caroline; Ronco, Pierre; Godin, Michel

    2008-08-01

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a systemic arterial disease characterized by impairment of vascular smooth muscle cell structure and function related to NOTCH3 mutations. Pathological findings include pathognomonic granular osmiophilic material (GOM) deposition with nonspecific hyalinization within the artery wall in a variety of tissues. The main clinical presentation is iterative strokes in young adults despite the lack of cardiovascular risk factors, leading to early dementia. Although arteriosclerosis and GOM have been found in kidneys from patients with CADASIL, kidney disease has been described only once up to now, in association with immunoglobulin A nephropathy. We report the case of a 61-year-old patient with a medical history of CADASIL and recent mild hypertension. His mother also showed neuropsychiatric symptoms and end-stage renal disease of unknown cause. The patient had a chronic kidney disease defined by means of estimated glomerular filtration rate using the 4-variable Modification of Diet in Renal Disease Study equation of 58 mL/min/1.73 m(2) associated with mild proteinuria and intermittent microscopic hematuria. Renal histological analysis showed severe arteriosclerosis and mild interstitial fibrosis. Glomeruli did not show mesangial immunoglobulin A deposition or focal segmental proliferation. Electron microscopic analysis showed typical GOM deposition in the vicinity of altered vascular smooth muscle cells in interlobular and juxtaglomerular arteries. The nephroangiosclerosis-like lesions were unusually severe in contrast to the recent mild hypertension. The presence of GOM strongly suggests that renal lesions were related to the NOTCH3 mutation. Here, we describe the first case of familial occurrence of kidney disease with decreased kidney function in the absence of coexisting nephropathy in patients with CADASIL. We discuss the role of NOTCH3 mutation in the pathogenesis

  14. Heart wall is thicker on postmortem computed tomography than on antemortem [corrected] computed tomography: the first longitudinal study.

    Directory of Open Access Journals (Sweden)

    Hidemi Okuma

    Full Text Available OBJECTIVE: To evaluate the postmortem changes of the heart wall on postmortem (PM computed tomography (CT in comparison with those on ante mortem CT (AMCT, and in comparison with the pathological findings, obtained in the same patients. MATERIALS AND METHODS: We studied 57 consecutive patients who had undergone AMCT, PMCT, and pathological autopsy in our tertiary care hospital between April 2009 and December 2010. PMCT was performed within 20 hours after death, followed by pathological autopsy. The cardiac chambers were measured at five sites on both AMCT and PMCT by two board-certified radiologists who were not provided with clinical information. The differences in heart wall thickness between AMCT with and without contrast medium, between AMCT and PMCT, and between PMCT and pathological anatomy were evaluated statistically. Confounding factors of postmortem change such as gender, presence of arteriosclerosis, the organ related to cause of death, age, and elapsed time since death were examined statistically. RESULTS: No significant differences were observed on AMCT in comparison of contrasted and non-contrasted images. The heart wall was significantly thicker on PMCT than on AMCT (p < 0.0001 at all five measurement sites. The heart wall was significantly thicker on PMCT than on pathology specimens when measured in accordance with pathological standard mensuration. However, no significant difference was observed between PMCT measurements and those of pathology specimens at any site when the papillary muscles and epicardial fat were included. No significant association was found between postmortem change in heart wall thickness and gender, presence of arteriosclerosis, the organ related to cause of death, age, or elapsed time since death. CONCLUSION: This is the first longitudinal study to confirm greater thickness of heart wall on postmortem images compared with ante mortem images, in the same patients. Furthermore, the postmortem changes on CT

  15. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

    Directory of Open Access Journals (Sweden)

    Fujimoto Kei

    2007-09-01

    Full Text Available Abstract Background Although oxidative stress by accumulation of reactive oxygen species (ROS in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for development of atherosclerosis in diabetes. This study evaluated the effect of genetic polymorphism of enzymes producing or responsible for reducing ROS on coronary artery calcification in type 2 diabetes (T2D. Methods An index for coronary-arteriosclerosis, coronary artery calcium score (CACS was evaluated in 91 T2D patients using a multi-slice computed tomography. Patients were genotyped for ROS-scavenging enzymes, Glutathione peroxidase-1 (GPx-1, Catalase, Mn-SOD, Cu/Zn-SOD, as well as SNPs of NADPH oxidase as ROS-promoting elements, genes related to onset of T2D (CAPN10, ADRB3, PPAR gamma, FATP4. Age, blood pressure, BMI, HbA1c, lipid and duration of diabetes were evaluated for a multivariate regression analysis. Results CACS with Pro/Leu genotype of the GPx-1 gene was significantly higher than in those with Pro/Pro (744 ± 1,291 vs. 245 ± 399, respectively, p = 0.006. In addition, genotype frequency of Pro/Leu in those with CACS ≥ 1000 was significantly higher than in those with CACS OR = 3.61, CI = 0.97–13.42; p = 0.045 when tested for deviation from Hardy-Weinberg's equilibrium. Multivariate regression analyses revealed that CACS significantly correlated with GPx-1 genotypes and age. Conclusion The presence of Pro197Leu substitution of the GPx-1 gene may play a crucial role in determining genetic susceptibility to coronary-arteriosclerosis in T2D. The mechanism may be associated with a decreased ability to scavenge ROS with the variant GPx-1.

  16. Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure

    Directory of Open Access Journals (Sweden)

    Sakamoto Masaya

    2012-10-01

    Full Text Available Abstract Background Angiotensin receptor blockers (ARBs are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1 whether an ARB (candesartan decreases values for inflammatory parameters in hypertensive patients with type 2 diabetes mellitus of long duration accompanied by arteriosclerosis and (2 whether there any predictors of which patients would receive the benefits of organ protection by candesartan. Methods We administered candesartan therapy (12 mg daily for 6 months and evaluated whether there was improvement in serum inflammatory parameters high molecular weight adiponectin (HMW-ADN, plasminogen activator inhibitor-1 (PAI-1, highly sensitive C-reactive protein (Hs-CRP, vascular cell adhesion molecule-1 (VCAM-1 in serum and urinary-8-hydroxydeoxyguanosine (U-8-OHdG. We then analyzed the relationship between the degree of lowering of blood pressure and inflammatory factors and the relationship between pulse pressure and inflammatory factors. Finally, we analyzed predictive factors in patients who received the protective benefit of candesartan. Results After 6 months of treatment, significant improvements from baseline values were observed in all patients in HMW-ADN and PAI-1 but not in Hs-CRP, VCAM-1 and U-8-OHdG. Multilinear regression analysis was performed to determine which factors could best predict changes in HMW-ADN and PAI-1. Changes in blood pressure were not significant predictors of changes in metabolic factors in all patients. We found that the group with baseline pulse pressure Conclusions Candesartan improved inflammatory parameters (HMW-ADN and PAI-1 in hypertensive patients with type 2 diabetes mellitus of long duration independent of blood pressure changes. Patients with pulse pressure Trial registration UMIN000007921

  17. Characterization of the apolipoprotein AI and CIII genes in the domestic pig

    Energy Technology Data Exchange (ETDEWEB)

    Birchbauer, A.; Knipping, G.; Juritsch, B.; Zechner, R. (Univ. of Graz (Austria)); Aschauer, H. (Sandoz-Forschungs Institut Ges.m.b.H., Vienna (Austria))

    1993-03-01

    The apolipoproteins (apo) AI and CIII are important constituents of triglyceride-rich lipoproteins and high-density lipoproteins. In humans, apo AI is believed to play an important protective role in the pathogenesis of arteriosclerosis, whereas apo CIII might be involved in the development of hypertriglyceridemia. Both human genes are located within a gene cluster on chromosome 11. Although the domestic pig has been widely used as an animal model in arteriosclerosis and lipid research, the porcine apolipoproteins genes are poorly characterized. In this report, the complete nucleotide sequences of the porcine apo AI and CIII genes are presented and the authors demonstrate, for the first time, apo CIII expression in the pig. Both genes are composed of four exons and three introns and resemble closely their human counterparts with regard to the transcriptional start sites, exon sizes, intron sizes, exon-intron borders, and the size of the intergenic region. The predicted pig apo AI is a protein of 241 amino acids, which is 2 amino acids shorter than human apo AI. The protein sequence was found to be very homologous to apo AI sequences in other mammalian species. Apo AI expression was detected on the mRNA level in porcine liver and intestine. The apo CIII gene encodes a protein with 73 amino acids, which is 6 amino acids shorter than human apo CIII. In contrast to the three isoforms of apo CIII found in humans, only one major isoform was detected in the pig. Presumably this isoform is unglycosylated. In addition to apo CIII expression in the liver and the intestine, a truncated form of apo CIII mRNA was also found in porcine kidney. The studies demonstrate the presence of an apo CIII gene, an apo CIII mRNA, and an apo CIII protein in the pig and, therefore, exclude a hypothesized apo CIII deficiency in these animals. 53 refs., 5 figs.

  18. Chemical pathology of homocysteine. V. Thioretinamide, thioretinaco, and cystathionine synthase function in degenerative diseases.

    Science.gov (United States)

    McCully, Kilmer S

    2011-01-01

    Hyperhomocysteinemia was first associated with degenerative disease by observation of accelerated arteriosclerosis in children with inherited disorders of cystathionine synthase, methionine synthase, and methylene tetrohydrofolate reductase. The metabolic blockade of sulfate synthesis from homocysteine thiolactone in malignant cells is ascribed to a deficiency of a chemopreventive derivative of homocysteine thiolactone that occurs in normal cells. Its chemical structure was elucidated by the organic synthesis of thioretinamide from retinoic acid and homocysteine thiolactone. Oxidation of the sulfur atom of homocysteine is inhibited in scorbutic guinea pigs, demonstrating ascorbate function in sulfate synthesis from homocysteine. Studies of homocysteine metabolism in protein energy malnutrition led to the conclusion that the biosynthesis of thioretinamide from the retinol of transthyretin is catalyzed by dehydroascorbate and superoxide generated from the heme oxygenase group of cystathionine synthase. Newly synthesized thioretinamide is complexed with cobalamin to form thioretinaco, which is activated by ozone and oxygen to function as the active site of oxidative phosphorylation. In accordance with the trophoblastic theory of cancer, pancreatic enzymes are believed to be oncolytic because they hydrolyze the homocysteinylated proteins, nucleic acids and glycosaminoglycans of malignant tissues. The clonal selection of malignant cells that are deficient in the heme oxygenase function of cystathionine synthase produces cells dependent upon glycolysis for ATP synthesis, since they are deficient in synthesis of thioretinamide, thioretinaco and thioretinaco ozonide. The vulnerable plaque of arteriosclerosis originates from complexes of microbes with homocysteinylated lipoproteins, obstructing vasa vasorum narrowed by endothelial dysfunction, causing arterial ischemia, and intimal micro-abscesses. Degenerative diseases may be ameliorated by a proposed therapeutic protocol

  19. High-resolution computed tomography of the lungs in pediatric patients; Hochaufloesende Computertomographie der Lunge im Kindesalter

    Energy Technology Data Exchange (ETDEWEB)

    Reuter, M.; Oppermann, H.C.; Biederer, J.; Heller, M. [Klinik fuer Diagnostische Radiologie, Universitaetsklinikum Kiel (Germany); Ankermann, T. [Klinik fuer Allgemeine Paediatrie, Universitaetsklinikum Kiel (Germany)

    2002-06-01

    Since the introduction of the high-resolution technique more than ten years ago, HRCT has become an established modality for diagnosing diseases of the respiratory system. This is especially true for the diagnosis of lung diseases in adults. Experience in HRCT of the lungs is limited in pediatric patients. This review gives an overview of frequent and less frequent HRCT findings in pulmonary diseases in childhood. A purely reticular pattern is rarely observed in infants. Pulmonary diseases associated with overinflation are relatively frequent. Paired inspiratory-expiratory scans combine morphological analysis with functional information and have improved the diagnosis of air trapping, e.g. in post-infectious bronchiolitis obliterans or bronchopulmonary dysplasia. Especially in children the high radiation exposure is a problem. Even when applying a low-dose protocol the radiation dose of HRCT will still exceed the dose of a chest X-ray by 100 times. The indication for pediatric pulmonary HRCT is limited to selected cases and it should be decided in agreement with the pediatric radiologists and the pediatric pulmonologists. (orig.) [German] Seit Einfuehrung der hochaufloesenden Computertomographie (HRCT) vor gut 10 Jahren hat sich diese Untersuchungstechnik fuer die Diagnostik von Erkrankungen der Atemwege und des Lungenparenchyms etabliert. Dies gilt vor allem fuer Lungenerkrankungen im Erwachsenenalter. Demgegenueber bestehen vergleichsweise wenig Erfahrungen mit der HRCT in der paediatrischen Lungendiagnostik. In der vorliegenden Uebersichtsarbeit werden HRCT-Befunde bei haeufigen und seltener vorkommenden Lungenerkrankungen bei Kindern beschrieben. Ein rein retikulaeres Muster ist im Kindesalter selten. Demgegenueber werden mit einer pulmonalen Obstruktion (Air trapping) einhergehende Erkrankungen gehaeuft beobachtet. Paarige Inspirations-Exspirationsaufnahmen ergaenzen die rein strukturelle Analyse um eine funktionelle Komponente und haben sich bei obstruktiven

  20. Popcorn worker's lung: In vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine

    International Nuclear Information System (INIS)

    Workers who inhale microwave popcorn butter flavorings experience decrements in lung function and can develop clinical bronchiolitis obliterans, i.e., 'popcorn worker's lung' (Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E.J., Enright, P.L., 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347, 330-338.). In a rat inhalation model, vapors of an artificial butter flavoring damaged the epithelium of the upper and lower airways (Hubbs, A.F., Battelli, L.A., Goldsmith, W.T., Porter, D.W., Frazer, D., Friend, S., Schwegler-Berry, D., Mercer, R.R., Reynolds, J.S., Grote, A., Castranova, V., Kullman, G., Fedan, J.S., Dowdy, J., Jones, W.G., 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185, 128-135.). Diacetyl, a butter flavoring component, is a major volatile ketone in the popcorn-processing workplace. We investigated the effects of diacetyl on epithelium of guinea pig isolated airway preparations and the effects of diacetyl in vitro on reactivity to bronchoactive agents. In the isolated, perfused trachea preparation, diacetyl added to the intraluminal (mucosal) bath elicited responses that began with contraction (threshold ca. 3 mM) and ended with relaxation. After a 4-h incubation with intraluminal diacetyl (3 mM), contractions to extraluminal (serosal) methacholine (MCh) were slightly increased; however, sensitivity to intraluminally (mucosally) applied MCh was increased by 10-fold. Relaxation responses of MCh (3 x 10-7 M)-contracted tracheas to extraluminally applied terbutaline and intraluminally applied 120 mM KCl, to evoke epithelium-derived relaxing factor release, were unaffected by diacetyl. Exposure of the tracheal epithelium in Ussing chambers to diacetyl decreased transepithelial potential difference and resistance. These findings suggest that diacetyl exposure compromised epithelial barrier function, leading to