WorldWideScience

Sample records for arterial transit time

  1. Noninvasive pulse transit time measurement for arterial stiffness monitoring in microgravity.

    Science.gov (United States)

    McCall, Corey; Rostosky, Rea; Wiard, Richard M; Inan, Omer T; Giovangrandi, Laurent; Cuttino, Charles Marsh; Kovacs, Gregory T A

    2015-08-01

    The use of a noninvasive hemodynamic monitor to estimate arterial stiffness, by measurement of pulse transit time (PTT), was demonstrated in microgravity. The monitor's utility for space applications was shown by establishing the correlation between ground-based and microgravity-based measurements. The system consists of a scale-based ballistocardiogram (BCG) and a toe-mounted photoplethysmogram (PPG). PTT was measured from the BCG I-wave to the intersecting tangents of the first trough and maximum first derivative of the PPG waveforms of each subject. The system was tested on a recent series of parabolic flights in which the PTT of nine subjects was measured on the ground and in microgravity. An average of 60.2 ms PTT increase from ground to microgravity environments was shown, and was consistent across all test subjects (standard deviation = 32.9 ms). This increase in PTT could be explained by a number of factors associated with microgravity and reported in previous research, including elimination of hydrostatic pressure, reduction of intrathoracic pressure, and reduction of mean arterial pressure induced by vasodilation. PMID:26737764

  2. Continuous blood pressure measurement using the pulse transit time: Comparison to intra-arterial measurement.

    Science.gov (United States)

    Patzak, Andreas; Mendoza, Yuri; Gesche, Heiko; Konermann, Martin

    2015-01-01

    Continuous blood pressure (BP) measurement allows the investigation of transient changes in BP and thus may give insights into mechanisms of BP control. We validated a continuous, non-invasive BP measurement based on the pulse transit time (PTT), i.e., BP(PTT), by comparing it with the intra-arterial BP (BP(i.a.)) measurement. Twelve subjects (five females and seven males) were included. BP(i.a.) was obtained from the radial artery using a system from ReCor Medical. Systolic and diastolic BP were calculated using the PTT (BP(PTT), SOMNOscreen). (PTT) was determined from the electrocardiogram and the peripheral pulse wave. The BP was modulated by application of increasing doses of dobutamine (5, 10, 20 μg/kg body mass). Systolic BP(PTT) and systolic BP(i.a.) correlated significantly (R = 0.94). The limits of agreement in the Bland-Altman plot were ± 19 mmHg; the mean values differed by 1 mmHg. The correlation coefficient for the diastolic BP measurements was R = 0.42. The limits of agreement in the Bland-Altman plot were ± 18 mmHg, with a mean difference of 5 mmHg in favour of the BP(PTT). The study demonstrates a significant correlation between the measurement methods for systolic BP. The results encourage the application of PTT-based BP measurement for the evaluation of BP dynamics and pathological BP changes. PMID:25857601

  3. Noninvasive tracking of systolic arterial blood pressure using pulse transit time measured with ECG and carotid doppler signals with intermittent calibration

    OpenAIRE

    Fujita, Yoshihisa

    2016-01-01

    We have developed a non-invasive blood pressure measurement system using pulse transit time (PTT) from the heart to the common carotid artery, measured by using an electrocardiogram (ECG) R-wave and carotid arterial Doppler signals at the anterior neck. In this study, we examined the validity of our system by comparing PTT derived systolic blood pressure (Dopp_SBP) with invasive radial systolic arterial pressure (Inv_SBP) with calibration every 15 min in the ICU setting.Methods: 17 patients u...

  4. Transition time

    Directory of Open Access Journals (Sweden)

    Carlos Renato Zacharias

    2013-03-01

    Full Text Available 2013 is going to be an interesting year for the High Dilution research field. There is a tendency to revise basic concepts and common beliefs, while refining models and theories. The fundamental research team seems to be open to deeper discussions, aiming to reinforce some hypothesis and discharge others. In somehow, we are stuck in a vicious way of think, trying to manage and describe an informational phenomenon into a molecular framework. The challenge offered to those researchers involved with basic science is to figure out how to deal with such phenomenon, since previous theories and models have not shown to be matched! In the other hand, there is a tendency to explore the HD phenomenon in its technological branch. While basic research is important to describe how things work, the applied research has a more intense social and economic appeal. To develop technology based on HD means to give a different kind of visibility to the field, attracting sponsors, companies, entrepreneurs, always committed to the market regulatory laws. I am expecting for this year some important movements, both in the basic and applied research. Of course, it will be only a new beginning, as these changes require a lot of work, discussions and insights. But this transition time is very welcome!

  5. Vascular Steal Explains Early Paradoxical Blood Oxygen Level-Dependent Cerebrovascular Response in Brain Regions with Delayed Arterial Transit Times

    Directory of Open Access Journals (Sweden)

    Julien Poublanc

    2013-04-01

    Full Text Available Introduction: Blood oxygen level-dependent (BOLD magnetic resonance imaging (MRI during manipulation of inhaled carbon dioxide (CO2 can be used to measure cerebrovascular reactivity (CVR and map regions of exhausted cerebrovascular reserve. These regions exhibit a reduced or negative BOLD response to inhaled CO2. In this study, we sought to clarify the mechanism behind the negative BOLD response by investigating its time delay (TD. Dynamic susceptibility contrast (DSC MRI with the injection of a contrast agent was used as the gold standard in order to provide measurement of the blood arrival time to which CVR TD could be compared. We hypothesize that if negative BOLD responses are the result of a steal phenomenon, they should be synchronized with positive BOLD responses from healthy brain tissue, even though the blood arrival time would be delayed. Methods: On a 3-tesla MRI system, BOLD CVR and DSC images were collected in a group of 19 patients with steno-occlusive cerebrovascular disease. For each patient, we generated a CVR magnitude map by regressing the BOLD signal with the end-tidal partial pressure of CO2 (PETCO2, and a CVR TD map by extracting the time of maximum cross-correlation between the BOLD signal and PETCO2. In addition, a blood arrival time map was generated by fitting the DSC signal with a gamma variate function. ROI masks corresponding to varying degrees of reactivity were constructed. Within these masks, the mean CVR magnitude, CVR TD and DSC blood arrival time were extracted and averaged over the 19 patients. CVR magnitude and CVR TD were then plotted against DSC blood arrival time. Results: The results show that CVR magnitude is highly correlated to DSC blood arrival time. As expected, the most compromised tissues with the longest blood arrival time have the lowest (most negative CVR magnitude. However, CVR TD shows a noncontinuous relationship with DSC blood arrival time. CVR TD is well correlated to DSC blood arrival time

  6. Searching for transit timing variations in transiting exoplanet systems

    CERN Document Server

    Hrudková, Marie; Benn, Chris; Pollacco, Don; Gibson, Neale; Joshi, Yogesh; Harmanec, Petr; Tulloch, Simon

    2008-01-01

    Searching for transit timing variations in the known transiting exoplanet systems can reveal the presence of other bodies in the system. Here we report such searches for two transiting exoplanet systems, TrES-1 and WASP-2. Their new transits were observed with the 4.2m William Herschel Telescope located on La Palma, Spain. In a continuing programme, three consecutive transits were observed for TrES-1, and one for WASP-2 during September 2007. We used the Markov Chain Monte Carlo simulations to derive transit times and their uncertainties. The resulting transit times are consistent with the most recent ephemerides and no conclusive proof of additional bodies in either system was found.

  7. Antiplatelet therapy at the time of coronary artery bypass grafting

    DEFF Research Database (Denmark)

    Kremke, Michael; Tang, Mariann; Bak, Mikkel;

    2013-01-01

    OBJECTIVES: The purpose of this multicentre cohort study was to examine the relationship between antiplatelet therapy (APT) at the time of coronary artery bypass grafting (CABG) and postoperative bleeding complications, transfusion requirements and adverse cardiovascular events. METHODS: A matched...

  8. Verifying duration properties of timed transition systems

    DEFF Research Database (Denmark)

    Liu, Zhiming; Ravn, Anders P.; Li, Xiaoshan

    1998-01-01

    This paper proposes a method for formal real-time systems development:Requirements and high level design decisions are time interval properties and are therefore specified in the Duration Calculus (DC), while implementations are described bytimed transition systems (TTS). A link from implementation...

  9. Arterial pressure transfer characteristics: effects of travel time.

    Science.gov (United States)

    Westerhof, Berend E; Guelen, Ilja; Stok, Wim J; Wesseling, Karel H; Spaan, Jos A E; Westerhof, Nico; Bos, Willem Jan; Stergiopulos, Nikos

    2007-02-01

    We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood viscosity, and blood density. A three-element windkessel represented the distal arterial tree. Sensitivity analysis was performed in terms of frequency and magnitude of the peak of the transfer function and in terms of systolic, diastolic, and pulse pressure in the aorta. The root mean square error (RMSE) described the accuracy in wave-shape prediction. The percent change of these variables for a 25% alteration of each of the model parameters was calculated. Vessel length and diameter are found to be the most important parameters determining pressure transfer. Systolic and diastolic pressure changed <3% and RMSE <1.8 mmHg for a 25% change in vessel length and diameter. To investigate how arterial tapering influences the pressure transfer, a single uniform lossless tube was modeled. This simplification introduced only small errors in systolic and diastolic pressures (1% and 0%, respectively), and wave shape was less well described (RMSE, approximately 2.1 mmHg). Local (arm) vasodilation affects the transfer function little, because it has limited effect on the reflection coefficient. Since vessel length and diameter translate into travel time, this parameter can describe the transfer accurately. We suggest that with a, preferably, noninvasively measured travel time, an accurate individualized description of pressure transfer can be obtained. PMID:16963619

  10. Transit timing to first order in eccentricity

    CERN Document Server

    Agol, Eric

    2015-01-01

    Characterization of transiting planets with transit timing variations (TTVs) requires understanding how to translate the observed TTVs into masses and orbital elements of the planets. This can be challenging in multi-planet transiting systems, but fortunately these systems tend to be nearly plane-parallel and low eccentricity. Here we present a novel derivation of analytic formulae for TTVs that are accurate to first order in the planet-star mass ratios and in the orbital eccentricities. These formulae are accurate in proximity to first order resonances, as well as away from resonance, and compare well with more computationally expensive N-body integrations in the low eccentricity, low mass-ratio regime when applied to simulated and to actual multi-transiting Kepler planet systems. We make code available for implementing these formulae.

  11. Orocaecal transit time in Duchenne muscular dystrophy.

    OpenAIRE

    Korman, S H; Bar-Oz, B.; E. Granot; Meyer, S

    1991-01-01

    Smooth muscle degeneration may occur in Duchenne muscular dystrophy. We measured fasting orocaecal transit time in patients with advanced Duchenne muscular dystrophy and other muscular dystrophies and in healthy controls. No significant differences were found. In contrast to reports of gastric hypomotility in Duchenne muscular dystrophy, we found no evidence of impaired small intestinal motility.

  12. Transit time for third order resonance extraction

    CERN Document Server

    Pullia, M

    1996-01-01

    An important spin-off from accelerators is the use of synchrotrons for cancer therapy. A precise control of the extraction from the synchrotron is needed to satisfy the medical specifications and this has led to a renewed interest in the basic theory of third-order resonance extraction. In the present paper, a complete description of the transit time in the resonance (the time between a particle becoming unstable and reaching the electrostatic septum) is developed as a basis for future work predicting spill shapes and the influence of power supply ripple. The transit time is evaluated for constant tune and for a slowly varying tune. Both cases are subdivided into particles that start close simulation and are shown to be correct to within a few percent.

  13. Transition times in the Landau-Zener model

    OpenAIRE

    Vitanov, N. V.

    1998-01-01

    This paper presents analytic formulas for various transition times in the Landau-Zener model. Considerable differences are found between the transition times in the diabatic and adiabatic bases, and between the jump time (the time for which the transition probability rises to the region of its asymptotic value) and the relaxation time (the characteristic damping time of the oscillations which appear in the transition probability after the crossing). These transition times have been calculated...

  14. Linking age, survival, and transit time distributions

    Science.gov (United States)

    Calabrese, Salvatore; Porporato, Amilcare

    2015-10-01

    Although the concepts of age, survival, and transit time have been widely used in many fields, including population dynamics, chemical engineering, and hydrology, a comprehensive mathematical framework is still missing. Here we discuss several relationships among these quantities by starting from the evolution equation for the joint distribution of age and survival, from which the equations for age and survival time readily follow. It also becomes apparent how the statistical dependence between age and survival is directly related to either the age dependence of the loss function or the survival-time dependence of the input function. The solution of the joint distribution equation also allows us to obtain the relationships between the age at exit (or death) and the survival time at input (or birth), as well as to stress the symmetries of the various distributions under time reversal. The transit time is then obtained as a sum of the age and survival time, and its properties are discussed along with the general relationships between their mean values. The special case of steady state case is analyzed in detail. Some examples, inspired by hydrologic applications, are presented to illustrate the theory with the specific results. This article was corrected on 11 Nov 2015. See the end of the full text for details.

  15. Stiffness Indices and Fractal Dimension relationship in Arterial Pressure and Diameter Time Series in-Vitro

    Science.gov (United States)

    Cymberknop, L.; Legnani, W.; Pessana, F.; Bia, D.; Zócalo, Y.; Armentano, R. L.

    2011-12-01

    The advent of vascular diseases, such as hypertension and atherosclerosis, is associated to significant alterations in the physical properties of arterial vessels. Evaluation of arterial biomechanical behaviour is related to the assessment of three representative indices: arterial compliance, arterial distensibility and arterial stiffness index. Elasticity is the most important mechanical property of the arterial wall, whose natures is strictly non-linear. Intervention of elastin and collagen fibres, passive constituent elements of the arterial wall, is related to the applied wall stress level. Concerning this, appropriate tools are required to analyse the temporal dynamics of the signals involved, in order to characterize the whole phenomenon. Fractal geometry can be mentioned as one of those techniques. The aim of this study consisted on arterial pressure and diameter signals processing, by means of nonlinear techniques based on fractal geometry. Time series morphology was related to different arterial stiffness states, generated by means of blood flow variations, during experiences performed in vitro.

  16. Automatic segmentation of coronary artery tree based on multiscale Gabor filtering and transition region extraction

    Science.gov (United States)

    Wang, Fang; Wang, Guozhu; Kang, Lie; Wang, Juan

    2011-11-01

    This paper presents a novel segmentation method for extracting coronary artery tree from angiogram, which is based on multiscale Gabor filtering and transition region extraction. Firstly the enhanced image is obtained after multiscale Gabor filtering, then the transition region of the enhanced image is extracted using the local complexity algorithm, and the final segmentation threshold is calculated, finally the image segmentation is achieved. To evaluate the performance of the proposed approach, we carried out experiments on various sets of angiographic images, and compared its effects with those of the improved top-hat segmentation method. The experiments indicate that the proposed method outperforms the latter method about better extraction of small vessels, more background elimination, better visualized coronary artery tree and continuity of the vessels.

  17. Data processing in pulse transit time measurement

    Institute of Scientific and Technical Information of China (English)

    Jingmeng Zhang; Ye Li

    2008-01-01

    Pulse transit time (PTT) is used as a noninvasive and cuff-less parameter to estimate blood pressure.In this paper,we develop an algorithm to ohtain PTT rapidly,which is appropriate for micro-processor and could achieve good accuracy in PTT,even in noisy measurements.The algorithm is based on finite impulse response(FIR) filter to reduce the noise and an adaptive threshold to detect the significant points of ECG and PPG.Evaluation of this method is hased on the signals from our PTT-based blood pressure devices It is shown that the method works well for PPT calculation.

  18. Data processing in pulse transit time measurement

    Institute of Scientific and Technical Information of China (English)

    Jingmeng Zhang; Ye Li

    2008-01-01

    Pulse transit time(PTT) is used as a noninvasive and cuff-hss parameter to estimate blood pressure.In this paper,we develop an algorithm to obtain PTT rapidly,which is appropriate for micro-processor and could achieve good accuracy in PTT,even in noisy measurements.,The algorithm is based on finite impulse response(FIR) filter to reduce the noise and an adaptive threshold to detect the significant points of ECG and PPG.Evaluation of this method is based on the signals from our PTT-based blood pressure devices.It is shown that the method works well for PPT calculation.

  19. Rapid Fatal Outcome from Pulmonary Arteries Compression in Transitional Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Ioannis A. Voutsadakis

    2009-01-01

    Full Text Available Transitional cell carcinoma of the urinary bladder is a malignancy that metastasizes frequently to lymph nodes including the mediastinal lymph nodes. This occurrence may produce symptoms due to compression of adjacent structures such as the superior vena cava syndrome or dysphagia from esophageal compression. We report the case of a 59-year-old man with metastatic transitional cell carcinoma for whom mediastinal lymphadenopathy led to pulmonary artery compression and a rapidly fatal outcome. This rare occurrence has to be distinguished from pulmonary embolism, a much more frequent event in cancer patients, in order that proper and prompt treatment be initiated.

  20. Transitional flow analysis in the carotid artery bifurcation by proper orthogonal decomposition and particle image velocimetry.

    Science.gov (United States)

    Kefayati, Sarah; Poepping, Tamie L

    2013-07-01

    Blood flow instabilities in the carotid artery bifurcation have been highly correlated to clot formation and mobilization resulting in ischemic stroke. In this work, PIV-measured flow velocities in normal and stenosed carotid artery bifurcation models were analyzed by means of proper orthogonal decomposition (POD). Through POD analysis, transition to more complex flow was visualized and quantified for increasing stenosis severity. While no evidence of transitional flow was seen in the normal model, the 50%-stenosed model started to show characteristics of transitional flow, which became highly evident in the 70% model, with greatest manifestation during the systolic phase of the cardiac cycle. By means of a model comparison, we demonstrate two quantitative measures of the flow complexity through the power-law decay slope of the energy spectrum and the global entropy. The more complex flow in the 70%-stenosed model showed a flatter slope of energy decay (-0.91 compared to -1.34 for 50% stenosis) and higher entropy values (0.26 compared to 0.17). Finally, the minimum temporal resolution required for POD analysis of carotid artery flow was found to be 100 Hz when determined through a more typical energy-mode convergence test, as compared to 400 Hz based on global entropy values.

  1. Theory of transit time ultrasonic flowmeters

    Science.gov (United States)

    Hemp, J.

    1982-09-01

    A theory of transit time ultrasonic flowmeters for clean fluids is developed from the equations of fluid mechanics applied simultaneously to the fluid and the sound vibrations. These equations are linearized (weak sound) and use is made of the electroacoustic reciprocity theorem to give a relation between the voltages and currents at the transducer terminals and the fluid velocity. The technique of "reciprocal operation" of a transit time ultrasonic flowmeter is described and the way this technique eliminates zero drift is explained. The theory can be applied to meters with broad sound beams (which provide a better average over velocity profiles) or meters in which the wavelength of sound is not necessarily small compared with the duct diameter. Small modificaition of the sound field (due to flow) is assumed and the resulting phase (or amplitude) shift of the received signal is expressed as an integral throughout the fluid of the dot product of the fluid velocity and a weight vector defined in terms of the sound fields in the stationary fluid. Simple flowmeter designs which approach the ideal of complete immunity to velocity distribution are described.

  2. On the estimation of arterial route travel time distribution with Markov chains

    OpenAIRE

    Ramezani Ghalenoei, Mohsen; Geroliminis, Nikolaos

    2012-01-01

    Recent advances in the probe vehicle deployment offer an innovative prospect for research in arterial travel time estimation. Specifically, we focus on the estimation of probability distribution of arterial route travel time, which contains more information regarding arterial performance measurements and travel time reliability. One of the fundamental contributions of this work is the integration of travel time correlation of route's successive links within the methodology. In the proposed te...

  3. Emitter space charge layer transit time in bipolar junction transistors

    Science.gov (United States)

    Rustagi, S. C.; Chattopadhyaya, S. K.

    1981-04-01

    The charge defined emitter space charge layer transit times of double diffused transistors have been calculated using a regional approach, and compared with the corresponding base transit times. The results obtained for emitter space-charge layer transit times have been discussed with reference to the capacitance analysis of Morgan and Smit (1960) for graded p-n junctions.

  4. Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time.

    Science.gov (United States)

    Fan, Tingting; Lu, Yuan; Gao, Yan; Meng, Jie; Tan, Wenchang; Huo, Yunlong; Kassab, Ghassan S

    2016-03-21

    Although the left internal mammary artery (LIMA) bypass graft is the best choice for surgical revascularization, its hemodynamics are still complex and can result in long-term graft failure. Here, we performed a hemodynamic analysis of the LIMA-coronary artery with end-to-side/side-to-side anastomoses based on 15 patient-specific CTA images at various postoperative periods. We hypothesize that hemodynamic patterns are determined by the interplay of LIMA geometry, anastomotic configuration, and severity of native coronary artery stenosis, which are strongly affected by the postoperative time. A 3D finite volume method with the inlet pressure wave and outlet resistance boundary conditions was used to compute the distribution of pressure and flow, from which the time-averaged wall shear stress (TAWSS), oscillation shear index (OSI), time-averaged WSS gradient (TAWSSG), and transverse WSS (transWSS) were determined. To characterize the hemodynamic environment, we defined surface area ratios of low TAWSS (≤4dynes/cm(2)), high OSI (≥0.15), TAWSSG (≥500dynes/cm(3)), and transWSS (≥6dynes/cm(2)) in the LIMA graft and at the anastomosis between LIMA graft and coronary artery. These ratios were determined by the interplay of multiple morphometric parameters in the LIMA-coronary artery, but increased with postoperative time. These findings have significant implications for understanding LIMA graft patency. PMID:26900034

  5. Cuff-Free Blood Pressure Estimation Using Pulse Transit Time and Heart Rate

    OpenAIRE

    Wang, Ruiping; Jia, Wenyan; Mao, Zhi-Hong; Sclabassi, Robert J.; Sun, Mingui

    2014-01-01

    It has been reported that the pulse transit time (PTT), the interval between the peak of the R-wave in electrocardiogram (ECG) and the fingertip photoplethysmogram (PPG), is related to arterial stiffness, and can be used to estimate the systolic blood pressure (SBP) and diastolic blood pressure (DBP). This phenomenon has been used as the basis to design portable systems for continuously cuff-less blood pressure measurement, benefiting numerous people with heart conditions. However, the PTT-ba...

  6. Measuring bovine mammary gland blood flow using a transit time ultrasonic flow probe.

    Science.gov (United States)

    Gorewit, R C; Aromando, M C; Bristol, D G

    1989-07-01

    Lactating cattle were used to validate a transit time ultrasonic blood flow metering system for measuring mammary gland arterial blood flow. Blood flow probes were surgically placed around the right external pudic artery. An electromagnetic flow probe was implanted in tandem with the ultrasonic probe in two cows for comparative measurements. The absolute accuracy of the implanted flow probes was assessed in vivo by mechanical means on anesthetized cows after 2 to 3 wk of implantation. The zero offset of the ultrasonic probes ranged from -12 to 8 ml/min. When the ultrasonic probe was properly implanted, the slopes of the calibration curves were linear and ranged from .92 to .95, tracking absolute flow to within 8%. The transit time instrument's performance was examined under a variety of physiological conditions. These included milking and hormone injections. The transit time ultrasonic flow meter accurately measured physiological changes in mammary arterial blood flow in chronically prepared conscious cattle. Blood flow increased 29% during milking. Epinephrine decreased mammary blood flow by 90 to 95%. Oxytocin doses increased mammary blood flow by 15 to 24%. PMID:2674232

  7. Timing Detection of Eclipsing Binary Planets and Transiting Extrasolar Moons

    OpenAIRE

    Doyle, L. R.; Deeg, H. J.

    2003-01-01

    We investigate the improved detection of extrasolar planets around eclipsing binaries using eclipse minima timing, and extrasolar moons around transiting planets using transit timing, offered by the upcoming COROT (ESA, 2005), Kepler (NASA, 2007), and Eddington (ESA 2008) spacecraft missions. Hundreds of circum-binary planets should be discovered, and a thorough survey of moons around transiting planets will be accomplished by these missions.

  8. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VIII. CATALOG OF TRANSIT TIMING MEASUREMENTS OF THE FIRST TWELVE QUARTERS

    Energy Technology Data Exchange (ETDEWEB)

    Mazeh, Tsevi; Nachmani, Gil; Holczer, Tomer; Sokol, Gil [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of Chicago, 5640 Ellis Ave., Chicago, IL 60637 (United States); Ford, Eric B.; Ragozzine, Darin [Astronomy Department, University of Florida, Gainesville, FL 32111 (United States); Sanchis-Ojeda, Roberto [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Rowe, Jason F.; Lissauer, Jack J. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Zucker, Shay [Department of Geophysical, Atmospheric and Planetary Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences Tel Aviv University, 69978 Tel Aviv (Israel); Agol, Eric [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Carter, Joshua A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Quintana, Elisa V. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Welsh, William [Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 (United States)

    2013-10-01

    Following the works of Ford et al. and Steffen et al. we derived the transit timing of 1960 Kepler objects of interest (KOIs) using the pre-search data conditioning light curves of the first twelve quarters of the Kepler data. For 721 KOIs with large enough signal-to-noise ratios, we obtained also the duration and depth of each transit. The results are presented as a catalog for the community to use. We derived a few statistics of our results that could be used to indicate significant variations. Including systems found by previous works, we have found 130 KOIs that showed highly significant times of transit variations (TTVs) and 13 that had short-period TTV modulations with small amplitudes. We consider two effects that could cause apparent periodic TTV—the finite sampling of the observations and the interference with the stellar activity, stellar spots in particular. We briefly discuss some statistical aspects of our detected TTVs. We show that the TTV period is correlated with the orbital period of the planet and with the TTV amplitude.

  9. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VIII. CATALOG OF TRANSIT TIMING MEASUREMENTS OF THE FIRST TWELVE QUARTERS

    International Nuclear Information System (INIS)

    Following the works of Ford et al. and Steffen et al. we derived the transit timing of 1960 Kepler objects of interest (KOIs) using the pre-search data conditioning light curves of the first twelve quarters of the Kepler data. For 721 KOIs with large enough signal-to-noise ratios, we obtained also the duration and depth of each transit. The results are presented as a catalog for the community to use. We derived a few statistics of our results that could be used to indicate significant variations. Including systems found by previous works, we have found 130 KOIs that showed highly significant times of transit variations (TTVs) and 13 that had short-period TTV modulations with small amplitudes. We consider two effects that could cause apparent periodic TTV—the finite sampling of the observations and the interference with the stellar activity, stellar spots in particular. We briefly discuss some statistical aspects of our detected TTVs. We show that the TTV period is correlated with the orbital period of the planet and with the TTV amplitude

  10. Choosing information variables for transition probabilities in a time-varying transition probability Markov switching model

    OpenAIRE

    Andrew J. Filardo

    1998-01-01

    This paper discusses a practical estimation issue for time-varying transition probability (TVTP) Markov switching models. Time-varying transition probabilities allow researchers to capture important economic behavior that may be missed using constant (or fixed) transition probabilities. Despite its use, Hamilton’s (1989) filtering method for estimating fixed transition probability Markov switching models may not apply to TVTP models. This paper provides a set of sufficient conditions to justi...

  11. The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation

    DEFF Research Database (Denmark)

    Harpsøe, Kennet Bomann West; Hardis, S.; Hinse, T. C.;

    2012-01-01

    Aims: We present 11 high-precision photometric transit observations of the transiting super-Earth planet GJ1214b. Combining these data with observations from other authors, we investigate the ephemeris for possible signs of transit timing variations (TTVs) using a Bayesian approach. Methods: The ...

  12. Pulse transit times to the capillary bed evaluated by laser Doppler flowmetry

    International Nuclear Information System (INIS)

    The pulse transit time (PTT) of a wave over a specified distance along a blood vessel provides a simple non-invasive index that can be used for the evaluation of arterial distensibility. Current methods of measuring the PTT determine the propagation times of pulses only in the larger arteries. We have evaluated the pulse arrival time (PAT) to the capillary bed, through the microcirculation, and have investigated its relationship to the arterial PAT to a fingertip. To do so, we detected cardiac-induced pulse waves in skin microcirculation using laser Doppler flowmetry (LDF). Using the ECG as a reference, PATs to the microcirculation were measured on the four extremities of 108 healthy subjects. Simultaneously, PATs to the radial artery of the left index finger were obtained from blood pressure recordings using a piezoelectric sensor. Both PATs correlate in similar ways with heart rate and age. That to the microcirculation is shown to be sensitive to local changes in skin perfusion induced by cooling. We introduce a measure for the PTT through the microcirculation. We conclude that a combination of LDF and pressure measurements enables simultaneous characterization of the states of the macro and microvasculature. Information about the microcirculation, including an assessment of endothelial function, may be obtained from the responses to perturbations in skin perfusion, such as temperature stress or vasoactive substances

  13. Pulse-wave timing between the cervical carotid and intracranial arteries by means of wavelet transform

    NARCIS (Netherlands)

    Journee, HL; de Jonge, AB; Hamoen, DJ; Smit, A; van Bruggen, AC; Mooij, JJA; Boom, H; Robinson, C; Rutten, W; Neuman, M; Wijkstra, H

    1997-01-01

    Wavelet Transform (WT) is applied in a method for timing the blood pulse wave between the internal carotid artery: and one of the intracranial arteries. The required accuracy is a few milliseconds. In contrast to the Fourier Transform (FT), WT is an appropriate technique for the detection of non-sta

  14. Transit light curves with finite integration time: Fisher information analysis

    Energy Technology Data Exchange (ETDEWEB)

    Price, Ellen M. [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Rogers, Leslie A. [California Institute of Technology, MC249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

    2014-10-10

    Kepler has revolutionized the study of transiting planets with its unprecedented photometric precision on more than 150,000 target stars. Most of the transiting planet candidates detected by Kepler have been observed as long-cadence targets with 30 minute integration times, and the upcoming Transiting Exoplanet Survey Satellite will record full frame images with a similar integration time. Integrations of 30 minutes affect the transit shape, particularly for small planets and in cases of low signal to noise. Using the Fisher information matrix technique, we derive analytic approximations for the variances and covariances on the transit parameters obtained from fitting light curve photometry collected with a finite integration time. We find that binning the light curve can significantly increase the uncertainties and covariances on the inferred parameters when comparing scenarios with constant total signal to noise (constant total integration time in the absence of read noise). Uncertainties on the transit ingress/egress time increase by a factor of 34 for Earth-size planets and 3.4 for Jupiter-size planets around Sun-like stars for integration times of 30 minutes compared to instantaneously sampled light curves. Similarly, uncertainties on the mid-transit time for Earth and Jupiter-size planets increase by factors of 3.9 and 1.4. Uncertainties on the transit depth are largely unaffected by finite integration times. While correlations among the transit depth, ingress duration, and transit duration all increase in magnitude with longer integration times, the mid-transit time remains uncorrelated with the other parameters. We provide code in Python and Mathematica for predicting the variances and covariances at www.its.caltech.edu/∼eprice.

  15. A novel continuous cardiac output monitor based on pulse wave transit time.

    Science.gov (United States)

    Sugo, Yoshihiro; Ukawa, Teiji; Takeda, Sunao; Ishihara, Hironori; Kazama, Tomiei; Takeda, Junzo

    2010-01-01

    Monitoring cardiac output (CO) is important for the management of patient circulation in an operation room (OR) or intensive care unit (ICU). We assumed that the change in pulse wave transit time (PWTT) obtained from an electrocardiogram (ECG) and a pulse oximeter wave is correlated with the change in stroke volume (SV), from which CO is derived. The present study reports the verification of this hypothesis using a hemodynamic analysis theory and animal study. PWTT consists of a pre-ejection period (PEP), the pulse transit time through an elasticity artery (T(1)), and the pulse transit time through peripheral resistance arteries (T(2)). We assumed a consistent negative correlation between PWTT and SV under all conditions of varying circulatory dynamics. The equation for calculating SV from PWTT was derived based on the following procedures. 1. Approximating SV using a linear equation of PWTT. 2. The slope and y-intercept of the above equation were determined under consideration of vessel compliance (SV was divided by Pulse Pressure (PP)), animal type, and the inherent relationship between PP and PWTT. Animal study was performed to verify the above-mentioned assumption. The correlation coefficient of PWTT and SV became r = -0.710 (p 〈 0.001), and a good correlation was admitted. It has been confirmed that accurate continuous CO and SV measurement is only possible by monitoring regular clinical parameters (ECG, SpO2, and NIBP). PMID:21095971

  16. Transition: Germany in a race against time

    International Nuclear Information System (INIS)

    This article proposes an overview of the situation of Germany with respect to its objectives of energy transition. It outlines that some of these objectives might not be reached, notably as far as the 40 per cent reduction of CO2 emissions by 2020 is concerned. This reduction might reach only 33 to 34 per cent. More precisely and as shown in a table indicating the situation in 2014 and foreseen evolutions by 2020, 2030, 2040 and 2050, if the share of renewable energies is remarkably increasing in the electricity sector and is on the right way to compensate the shutdown nuclear reactors, such a trend is still expected in the heat production sector, and transports displays a trend in the wrong direction

  17. Simplified scintigraphic methods for measuring gastrointestinal transit times

    DEFF Research Database (Denmark)

    Graff, J; Brinch, K; Madsen, Jan Lysgård

    2000-01-01

    To investigate whether simple transit measurements based on scintigraphy performed only 0, 2, 4 and 24 h after intake of a radiolabelled meal can be used to predict the mean transit time values for the stomach, the small intestine, and the colon, a study was conducted in 16 healthy volunteers...... intestinal and colonic mean transit times were calculated for both markers and compared with fractional gastric emptying at 2 h, fractional colonic filling at 4 h, and geometric centre of colonic content at 24 h, respectively. Highly significant correlations were found between gastric mean transit time...... and fractional gastric emptying at 2 h (111In: r=0.95, Pintestinal mean transit time and fractional colonic filling at 4 h (111In: r=-0.97, P

  18. Cerebral Arterial Time Constant Recorded from the MCA and PICA in Normal Subjects.

    Science.gov (United States)

    Kasprowicz, Magdalena; Czosnyka, Marek; Poplawska, Karolina; Reinhard, Matthias

    2016-01-01

    Cerebral arterial time constant (τ) estimates how quickly the cerebral arterial bed distal to the point of insonation is filled with arterial blood following a cardiac contraction. It is not known how τ behaves in different vascular territories in the brain. We therefore investigated the differences in τ of two cerebral arteries: the posterior inferior cerebellar artery (PICA) and the middle cerebral artery (MCA).Transcranial Doppler cerebral blood flow velocity (CBFV) in the PICA and left MCA along with Finapres arterial blood pressure (ABP) were simultaneously recorded in 35 young healthy volunteers. τ was estimated using mathematical transformations of pulse waveforms of ABP and the CBFV of the MCA and the PICA. Since τ is independent from the vessel radius, its comparison in different cerebral arteries was feasible. Mean ABP was 76.1 ± 9.6 mmHg. The CBFV of the MCA was higher than that of the PICA (59.7 ± 7.7 vs. 41.0 ± 4.5 cm/s; p blood volume. This study thus confirms the physiological validity of the τ concept. PMID:27165908

  19. Time Varying Transition Probabilities for Markov Regime Switching Models

    OpenAIRE

    Bazzi, Marco; Blasques, Francisco; Koopman, Siem Jan; Lucas, Andre

    2014-01-01

    We propose a new Markov switching model with time varying probabilities for the transitions. The novelty of our model is that the transition probabilities evolve over time by means of an observation driven model. The innovation of the time varying probability is generated by the score of the predictive likelihood function. We show how the model dynamics can be readily interpreted. We investigate the performance of the model in a Monte Carlo study and show that the model is successful in estim...

  20. Validation of a 1-mm transit time flow probe and the potential for use in microsurgery

    DEFF Research Database (Denmark)

    Bonde, Christian T; Elberg, Jens J; Holstein-Rathlou, N.-H.

    2006-01-01

    rates did not previously exist. The experimental design was an in vitro study using the median artery of 15-kg pigs. The vessel was perfused by the pigs' own heparinated blood, at a known flow rate, using a Gemini infusion pump. The infusion rate was increased stepwise, starting at 1 ml/min until 16 ml....../min. Transit time flow was measured continuously. The results showed very accurate flow measurements at all flow rates when compared to the known infusion rate of the Gemini pump. However, at flow rates below 4 ml/min, variation became a problem....

  1. The liner shipping berth scheduling problem with transit times

    DEFF Research Database (Denmark)

    Reinhardt, Line Blander; Plum, Christian E.M.; Pisinger, David;

    2016-01-01

    In this paper speed optimization of an existing liner shipping network is solved by adjusting the port berth times. The objective is to minimize fuel consumption while retaining the customer transit times including the transhipment times. To avoid too many changes to the time table, changes of port...

  2. Arterial Stiffness and Walk Time in Patients with End-Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Abbi D. Lane

    2013-04-01

    Full Text Available Background: End-stage renal disease patients experience increased prevalence of cardiovascular disease. Heart-artery interaction may be shifted, impacting blood pressure lability, and exercise tolerance. The coupling ratio consists of the ratio of indexed arterial elastance (EaI, arterial load to ElvI, a measure of cardiac contractility or stiffness. Our purpose was to explore the relationship between elastances and functional capacity. We hypothesized that arterial stiffness (central pulse wave velocity, PWV and elastances would be correlated to shuttle walk time. Methods: We used applanation tonometry, ultrasonography, and a shuttle walk test to evaluate our hypothesis. Spearman's correlations were used to assess relationships between variables. Block regression was also performed. Results: Forty-two subjects on maintenance hemodialysis participated. Average age=44±5 years, body surface area=2.01 kg/m2. Mean EaI=4.45 and mean ElvI=6.89; the coupling ratio=0.82. Mean aortic pulse pressure=51 mmHg and PWV=9.6 m/s. PWV(r=-0.385 and EaI (r=-0.424 were significantly and inversely related to walking time while stroke volume index (SVI was positively correlated to shuttle walk time (r=0.337, pConclusions: We conclude that, like other clinical populations, both arterial and heart function predict walking ability and represent potential targets for intervention; arterial stiffness and SVI are strongly related to shuttle walk time in patients with ESRD.

  3. Transit timing observations from Kepler. V. Transit timing variation candidates in the first sixteen months from polynomial models

    DEFF Research Database (Denmark)

    Ford, E.B.; Ragozzine, D.; Holman, M.J.;

    2012-01-01

    Transit timing variations provide a powerful tool for confirming and characterizing transiting planets, as well as detecting non-transiting planets. We report the results of an updated transit timing variation (TTV) analysis for 1481 planet candidates based on transit times measured during...... the first sixteen months of Kepler observations. We present 39 strong TTV candidates based on long-term trends (2.8% of suitable data sets). We present another 136 weaker TTV candidates (9.8% of suitable data sets) based on the excess scatter of TTV measurements about a linear ephemeris. We anticipate...... that several of these planet candidates could be confirmed and perhaps characterized with more detailed TTV analyses using publicly available Kepler observations. For many others, Kepler has observed a long-term TTV trend, but an extended Kepler mission will be required to characterize the system via TTVs. We...

  4. Gastrointestinal transit times and motility in patients with cystic fibrosis

    DEFF Research Database (Denmark)

    Hedsund, Caroline; Gregersen, Tine; Jønsson, Iben;

    2012-01-01

    OBJECTIVE: Patients with cystic fibrosis (CF) often suffer from gastrointestinal (GI) dysfunction including obstructive symptoms, malabsorption and pain, but the underlying pathophysiology remains obscure. AIM: To compare GI motility and transit times in CF patients and healthy controls. MATERIAL...

  5. Measurement of mean transit time with radioactive tracers

    International Nuclear Information System (INIS)

    The purpose of this work was to validate the use of moment to computer transit time in radioactive tracer studies. In tracer dilution studies, input and output functions usually can be described by means of exponential and gamma-variate functions. The authors demonstrated mathematically that computation of transit time with use of the first moments of these modeling functions is equivalent to the use of impulse response functions. They used a test object that would emulate the transit time of pulmonary blood flow in a medium-size dog to validate the computation of transit time with the first moment. A bolus of 185 MBq (5 mCi) of Tc-99m pertechnetate was injected. The quality of the bolus injection was modified by changing the size of the bolus. The transit time obtained from the first moments of the tracer-dilution curves was in agreement with the first moments of the modeling mathematical functions. Transit time is radionuclide studies can be computed from either the first moment of the tracer-dilution curve or of the modeling mathematical functions. Derivation of the impulse response function is not necessary

  6. Developments in Planet Detection using Transit Timing Variations

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Agol, Eric; /Washington U., Seattle, Astron. Dept.

    2006-12-01

    In a transiting planetary system, the presence of a second planet will cause the time interval between transits to vary. These transit timing variations (TTV) are particularly large near mean-motion resonances and can be used to infer the orbital elements of planets with masses that are too small to detect by any other means. The author presents the results of a study of simulated data where they show the potential that this planet detection technique has to detect and characterize secondary planets in transiting systems. These results have important ramifications for planetary transit searches since each transiting system presents an opportunity for additional discoveries through a TTV analysis. They present such an analysis for 13 transits of the HD 209458 system that were observed with the Hubble Space Telescope. This analysis indicates that a putative companion in a low-order, mean-motion resonance can be no larger than the mass of the Earth and constitutes, to date, the most sensitive probe for extrasolar planets that orbit main sequence stars. The presence or absence of small planets in low-order, mean-motion resonances has implications for theories of the formation and evolution of planetary systems. Since TTV is most sensitive in these regimes, it should prove a valuable tool not only for the detection of additional planets in transiting systems, but also as a way to determine the dominant mechanisms of planet formation and the evolution of planetary systems.

  7. Simplified scintigraphic methods for measuring gastrointestinal transit times

    DEFF Research Database (Denmark)

    Graff, J; Brinch, K; Madsen, Jan Lysgård

    2000-01-01

    To investigate whether simple transit measurements based on scintigraphy performed only 0, 2, 4 and 24 h after intake of a radiolabelled meal can be used to predict the mean transit time values for the stomach, the small intestine, and the colon, a study was conducted in 16 healthy volunteers...... intestinal and colonic mean transit times were calculated for both markers and compared with fractional gastric emptying at 2 h, fractional colonic filling at 4 h, and geometric centre of colonic content at 24 h, respectively. Highly significant correlations were found between gastric mean transit time...... and fractional gastric emptying at 2 h (111In: r=0.95, Ptime and fractional colonic filling at 4 h (111In: r=-0.97, Ptime and geometric centre of colonic content...

  8. Bisimulation and Open Maps for Timed Transition Systems

    DEFF Research Database (Denmark)

    Nielsen, Mogens

    1999-01-01

    Formal models for real-time systems have been studied intensively over the past decade. Much of the theory of untimed systems have been lifted to real-time settings. One example is the notion of bisimulation applied to timed transition systems, which is studied here within the general categorical...

  9. Daylight Saving Time Transitions and Road Traffic Accidents

    Directory of Open Access Journals (Sweden)

    Tuuli Lahti

    2010-01-01

    Full Text Available Circadian rhythm disruptions may have harmful impacts on health. Circadian rhythm disruptions caused by jet lag compromise the quality and amount of sleep and may lead to a variety of symptoms such as fatigue, headache, and loss of attention and alertness. Even a minor change in time schedule may cause considerable stress for the body. Transitions into and out of daylight saving time alter the social and environmental timing twice a year. According to earlier studies, this change in time-schedule leads to sleep disruption and fragmentation of the circadian rhythm. Since sleep deprivation decreases motivation, attention, and alertness, transitions into and out of daylight saving time may increase the amount of accidents during the following days after the transition. We studied the amount of road traffic accidents one week before and one week after transitions into and out of daylight saving time during years from 1981 to 2006. Our results demonstrated that transitions into and out of daylight saving time did not increase the number of traffic road accidents.

  10. Planetary transit timing variations induced by stellar binarity. The light travel time effect

    CERN Document Server

    Montalto, M

    2010-01-01

    [ABRIDGED] Since the discovery of the first transiting extrasolar planet, transit timing has been recognized as a powerful method to discover and characterize additional planets in these systems. However, the gravitational influence of additional planets is not the only expected source of transit timing variations. In this work, we derive the expected detection frequency of stellar companions of hot-jupiter transiting planets host-stars, detectable by means of transit timing analysis. Since roughly half of the stars in the solar neighborhood belong to binary or multiple stellar systems, the same fraction of binary systems may be expected to be present among transiting planet-host stars, unless planet formation is significantly influenced by the presence of a stellar companion. Transit searches are less affected by the selection biases against long-period binaries that plague radial velocity surveys. If the frequency of binaries among hot-jupiter planets host stars is the same as determined in the solar neighb...

  11. Domain-wall formation in late-time phase transitions

    International Nuclear Information System (INIS)

    We investigate domain-wall formation in late-time phase transitions. We find that, as in the invisible-axion--domain-wall phenomenon, thermal effects alone are insufficient to drive different regions of the Universe to different parts of the disconnected vacuum manifold. This suggests that domain walls do not form unless either there is some supplemental (but perhaps not unreasonable) dynamics to localize the scalar field responsible for the phase transition to the low-temperature maximum (to an extraordinary precision) before the onset of the phase transition, or there is some nonthermal mechanism to produce large fluctuations in the scalar field. The fact that domain-wall production is not a robust prediction of late-time transitions may suggest future directions in model building

  12. TTVFaster: First order eccentricity transit timing variations (TTVs)

    Science.gov (United States)

    Agol, Eric; Deck, Katherine

    2016-04-01

    TTVFaster implements analytic formulae for transit time variations (TTVs) that are accurate to first order in the planet-star mass ratios and in the orbital eccentricities; the implementations are available in several languages, including IDL, Julia, Python and C. These formulae compare well with more computationally expensive N-body integrations in the low-eccentricity, low mass-ratio regime when applied to simulated and to actual multi-transiting Kepler planet systems.

  13. Ultrafast contrast-enhanced MR angiography of the carotid artery: time optimization for discrimination of the arterial from the venous phase

    International Nuclear Information System (INIS)

    To investigate the optimal delay and acquisition time for discrimination of the arterial from the venous phase in ultrafast 3D contrast-enhanced MR angiography of the carotid artery. We reviewed the MR angiographic findings of 233 patients in whom carotid stenosis and cerebrovascular disease were suspected. On the basis of delay and acquistition time they were divided into four groups. In the first three, contrast material was injected manually, and after the optimal time, mechanical injection was used for the last group. On the basis of signal intensity of the carotid artery, image quality was graded in four steps. Discrimination of the arterial from the venous phase was graded in three steps, based on the degree of venous enhancement. The best grade of image quality was 70% in the first group, 85% in the second, and 95% in the third. In discrimination of the arterial-venous phase, the most definite grade was 50% in the first group, 62% in the second, and 75% in the third. Between manual and mechanical injection groups, there was no significant difference in image quality and discrimination of the arterial-venous phase. These results suggest that for ultrafast 3D contrast-enhanced MR angiography of the carotid artery, with manual injection of contrast material, 8-second delay time and 7-second acqusistion time are optimal.=20

  14. Sharp asymptotics of metastable transition times for one dimensional SPDEs

    CERN Document Server

    Barret, Florent

    2012-01-01

    We consider a class of parabolic semi-linear stochastic partial differential equations driven by space-time white noise on a compact space interval. Our aim is to obtain precise asymptotics of the transition times between metastable states. A version of the so-called Eyring-Kramers Formula is proven in an infinite dimensional setting. The proof is based on a spatial finite difference discretization of the stochastic partial differential equation. The expected transition time is computed for the finite dimensional approximation and controlled uniformly in the dimension.

  15. High-Cadence Transit Timing Variation Monitoring of Extrasolar Planets

    Directory of Open Access Journals (Sweden)

    Naef D.

    2011-02-01

    Full Text Available We report ground-based high-cadence transit timing observations of the extrasolar planet WASP-2b. We achieve a typical timing error of 15-30 sec. The data show no significant deviations from the predicted ephemeris.

  16. Mean Transit Time and Mean Residence Time for Linear Diffusion–Convection–Reaction Transport System

    Directory of Open Access Journals (Sweden)

    Jacek Waniewski

    2007-01-01

    Full Text Available Characteristic times for transport processes in biological systems may be evaluated as mean transit times (MTTs (for transit states or mean residence times (MRT (for steady states. It is shown in a general framework of a (linear reaction–diffusion–convection equation that these two times are related. Analytical formulas are also derived to calculate moments of exit time distribution using solutions for a stationary state of the system.

  17. Distribution of capillary transit times in isolated lungs of oxygen-tolerant rats.

    Science.gov (United States)

    Ramakrishna, Madhavi; Gan, Zhuohui; Clough, Anne V; Molthen, Robert C; Roerig, David L; Audi, Said H

    2010-11-01

    Rats pre-exposed to 85% O₂ for 5-7 days tolerate the otherwise lethal effects of 100% O₂. The objective was to evaluate the effect of rat exposure to 85% O₂ for 7 days on lung capillary mean transit time t(c) and distribution of capillary transit times (h(c)(t)). This information is important for subsequent evaluation of the effect of this hyperoxia model on the redox metabolic functions of the pulmonary capillary endothelium. The venous concentration vs. time outflow curves of fluorescein isothiocyanate labeled dextran (FITC-dex), an intravascular indicator, and coenzyme Q₁ hydroquinone (CoQ₁H₂), a compound which rapidly equilibrates between blood and tissue on passage through the pulmonary circulation, were measured following their bolus injection into the pulmonary artery of isolated perfused lungs from rats exposed to room air (normoxic) or 85% O₂ for 7 days (hyperoxic). The moments (mean transit time and variance) of the measured FITC-dex and CoQ₁H₂ outflow curves were determined for each lung, and were then used in a mathematical model [Audi et al. J. Appl. Physiol. 77: 332-351, 1994] to estimate t(c) and the relative dispersion (RD(c)) of h (c)(t). Data analysis reveals that exposure to hyperoxia decreases lung t(c) by 42% and increases RD(c), a measure h(c)(t) heterogeneity, by 40%.

  18. Noise-induced transition in human reaction times

    Science.gov (United States)

    Medina, José M.; Díaz, José A.

    2016-09-01

    The human reaction/response time can be defined as the time elapsed from the onset of stimulus presentation until a response occurs in many sensory and cognitive processes. A reaction time model based on Piéron’s law is investigated. The model shows a noise-induced transition in the moments of reaction time distributions due to the presence of strong additive noise. The model also demonstrates that reaction times do not follow fluctuation scaling between the mean and the variance but follow a generalized version between the skewness and the kurtosis. The results indicate that noise-induced transitions in the moments govern fluctuations in sensory-motor transformations and open an insight into the macroscopic effects of noise in human perception and action. The conditions that lead to extreme reaction times are discussed based on the transfer of information in neurons.

  19. Stellar proper motion and the timing of planetary transits

    CERN Document Server

    Rafikov, Roman R

    2008-01-01

    Duration and period of transits in extrasolar planetary systems can exhibit long-term variations for a variety of reasons. Here we investigate how systemic proper motion, which steadily re-orients planetary orbit with respect to our line of sight, affects the timing of transits. We find that in a typical system with a period of several days proper motion at the level of 100 mas/yr makes transit duration vary at a rate ~10-100 ms/yr. In some isolated systems this variation is at the measurable level (can be as high as 0.6 s/yr for GJ436) and may exceed all other transit timing contributions (due to the general relativity, stellar quadrupole, etc.). In addition, proper motion causes evolution of the observed orbital period via the Shklovskii effect at a rate $\\gtrsim 10$ $\\mu$s/yr for the nearby transiting systems (0.26 ms/yr in GJ436), which in some cases exceeds all other contributions to $\\dot P$. Earth's motion around the Sun gives rise to additional periodic timing signal (even for systems with zero intrin...

  20. Two analytical solutions for a model of pulsed arterial spin labeling with randomized blood arrival times

    Science.gov (United States)

    Hrabe, J.; Lewis, D. P.

    2004-03-01

    A fairly general theoretical model for pulsed arterial spin labeling perfusion methods has been available for some time but analytical solutions were derived for only a small number of arterial blood input functions. These mostly assumed a sudden and simultaneous arrival of the tagged blood into the imaged region. More general cases had to be handled numerically. We present analytical solutions for two more realistic arterial input functions. They both allow the arrival times of the molecules of tagged arterial blood to be statistically distributed. We consider cases of (1) a uniform distribution on a finite time interval and (2) a normal distribution characterized by its mean and standard deviation. These models are physiologically meaningful because the statistical nature of the arrival times reflects the distribution of velocities and path lengths that the blood water molecules undertake from the tagging region to the imaged region. The model parameters can be estimated from the measured dependency of the perfusion signal on the tag inversion time.

  1. Oro-cecal transit time : influence of a subsequent meal

    NARCIS (Netherlands)

    Priebe, MG; Wachters-Hagedoorn, RE; Stellaard, F; Heiner, AM; Elzinga, H; Vonk, RJ

    2004-01-01

    Background Small intestinal and oro-cecal transit time (OCTT) is determined for clinical diagnostics and research purposes. Experimental protocols used vary with respect to the inclusion of a subsequent meal during the test period. This study was conducted to elucidate whether the ingestion of a sub

  2. Caregivers' Playfulness and Infants' Emotional Stress during Transitional Time

    Science.gov (United States)

    Jung, Jeesun

    2011-01-01

    The purpose of this study is to explore the playfulness of the teachers of infants and its relations to infants' emotional distress during the transitional time at a child care centre. The study used a qualitative case study. Two infant caregivers in a university-based child care centre participated in this study. For the three-month research…

  3. Does the transition into daylight saving time affect students' performance?

    OpenAIRE

    Herber, Stefanie P.; Quis, Johanna Sophie; Heineck, Guido

    2015-01-01

    We use international student assessment data on more than 22,000 students from six European countries and a regression discontinuity design to investigate whether the transition into daylight saving time (DST) affects elementary students' test performance in the week after the time change. We do not find reliable statistical effects on students' performance, neither in math, science nor reading. Our results therefore challenge the prevailing public opinion that DST should be abandoned because...

  4. Capsule endoscopy: Improving transit time and image view

    Institute of Scientific and Technical Information of China (English)

    Zvi Fireman; D Paz; Y Kopelman

    2005-01-01

    AIM: To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa.METHODS: Ninety-five patients underwent capsule endoscopy (CE) by easily swallowing the capsule. They were divided into three study groups according to the preparation used: group A (n = 26) by polyethylene glycol (PEG) liter or with sodium phosphate (SP) 12 h prior to the CE study; group B (n = 29) by erythromycin 1 h prior to the CE study; and group C (n = 40) without any preparation. Visualization ranged from good to satisfactory to poor.RESULTS: The gastric emptying time in the group prepared with erythromycin was shorter but without statistical significance and the small bowel transit time was unaffected. In elderly subjects prepared by PEG or SP, the gastric emptying time was significantly longer (163.7 min, P = 0.05). The transit times of the three sub-groups were not affected by gender or pathology.The grade of cleaning of the entire study group was 3.27±1.1. The erythromycin group presented significantly the worst quality of images (P = 0.05) compared to the other sub-groups. Age, gender, and pathology had no effect on the quality of the cleaning of the small bowel in the sub-groups. One (1.05%) case had no natural excretion.CONCLUSION: Erythromycin markedly reduces gastric emptying time, but has a negative effect on the quality of the image in the small bowel. The preparation of elderly subjects with PEG or SP has a negative effect on the small bowel transit time.

  5. Visual Analysis and Comparison of Kepler Transit Timing Variations with Mutli-Transiting System Applications

    Science.gov (United States)

    Kane, Mackenzie; Ragozzine, Darin; Flowers, Xzavier

    2016-10-01

    By noticing the dimming and brightening of the star as an exoplanet transit occurs, NASA's Kepler Space Telescope records the times when the exoplanet passes in front of its star. If other planets are gravitationally influencing the transiting planet, the planet might transit late or early; these deviations from a perfectly periodic set of transits are called transit timing variations (TTVs). Therefore, Kepler TTVs have been very useful in determining exoplanet masses which can be hard to measure in other ways.We visually analyzed the TTV data of all ~6000 Kepler objects of interest (KOIs) to determine whether interesting TTV signals would be missed by purely statistical analyses. Using data from Rowe et al. 2014 and Holczer et al. 2016, we examined TTV plots, periodograms, and folded quadratic+sinusoid fits. To find the most likely KOIs containing visible TTVs and to organize the over 6000 KOIs analyzed, a rating system was developed based on numerous visual factors. By sorting KOIs as such, we were able to compare our findings of the strongest candidates with the same KOIs statistically analyzed by Holczer et al. 2016. It was found that the majority of our findings matched those of Holczer et al. 2016, with only small discrepancies that were understandable based on our different methodologies. Still, our visual inspection of the full list of KOIs contributed multiple planets that were not identified statistically.We combined all of these results with planet properties from the NASA Exoplanet Archive, confirmed and cumulative, to investigate the demographics of planetary systems with and without TTVs. We investigated multi-transiting systems with TTVs not attributable to any of the known planets in the system to better understand exoplanetary system architectures in cases where not all of the planets are transiting.

  6. Transition in adolescents across time, disease and gender

    DEFF Research Database (Denmark)

    Svanholm, Jette Rolf; Ludvigsen, Mette Spliid; Aagaard, Hanne

    Transition in adolescents across time, disease and gender Jette Rolf Svanholm 1,2, Mette Spliid Ludvigsen 1,3, Hanne Aagaard 1,4,5 1 Aarhus University Hospital, Denmark 2 Department of Cardiology 3 Department of Renal Medicine 4 Department of Pediatrics 5 Institute of Public Health, Aarhus...... Recruited from outpatient clinics at Aarhus University Hospital in Denmark. • Ten adolescents at 14 years of age are selected in each group. • Follow-up is planned at 15 and 17 years of age. Ethical considerations The adolescents will be informing about the project and it will be clarify to the adolescents...... central characteristics across time, disease and gender. Perspectives It is expected that this study will create knowledge about the existential and interpersonal challenges of adolescents in transition as seen from the • time perspective • diagnose perspective • gender perspective These results will make...

  7. Dual-Priced Modal Transition Systems with Time Durations

    DEFF Research Database (Denmark)

    Beneš, Nikola; Kretínsky, Jan; Larsen, Kim Guldstrand;

    2012-01-01

    Modal transition systems are a well-established specification formalism for a high-level modelling of component-based software systems. We present a novel extension of the formalism called modal transition systems with durations where time durations are modelled as controllable or uncontrollable...... intervals. We further equip the model with two kinds of quantitative aspects: each action has its own running cost per time unit, and actions may require several hardware components of different costs. We ask the question, given a fixed budget for the hardware components, what is the implementation...... with the cheapest long-run average reward. We give an algorithm for computing such optimal implementations via a reduction to a new extension of mean payoff games with time durations and analyse the complexity of the algorithm....

  8. Electron transit time measurements of 5-in photomultiplier tubes

    Science.gov (United States)

    Richards, T.; Peatross, J.; Ware, M.; Rees, L.

    2016-08-01

    We investigated the uniformity of electron transit times for two 5-in photomultiplier tubes: the Hamamatsu R1250 and the Adit B133D01S. We focused a highly attenuated short-pulse laser on the tubes while they were mounted on a programmable stage. The stage translated the tubes relative to the incident beam so that measurements could be made with light focused at points along a grid covering the entire photocathodes. A portion of the incident light was split from the incident beam and measured and recorded by a fast photodiode. Electron transit times were measured by computing the time delay between the recorded photodiode signal and photomultiplier signal using software constant-fraction discrimination. The Hamamatsu tube exhibited a uniform timing response that varied by no more than 1.7 ns. The Adit tube was much less uniform, with transit times that varied by as much as 57 ns. The Adit response also exhibited a spatially varying double-peak structure in its response. The technique described in this paper could be usefully employed by photomultiplier tube manufacturers to characterize the performance of their products.

  9. Integrated response and transit time distributions of watersheds by combining hydrograph separation and long-term transit time modeling

    Directory of Open Access Journals (Sweden)

    M. C. Roa-García

    2010-08-01

    Full Text Available We present a new modeling approach analyzing and predicting the Transit Time Distribution (TTD and the Response Time Distribution (RTD from hourly to annual time scales as two distinct hydrological processes. The model integrates Isotope Hydrograph Separation (IHS and the Instantaneous Unit Hydrograph (IUH approach as a tool to provide a more realistic description of transit and response time of water in catchments. Individual event simulations and parameterizations were combined with long-term baseflow simulation and parameterizations; this provides a comprehensive picture of the catchment response for a long time span for the hydraulic and isotopic processes. The proposed method was tested in three Andean headwater catchments to compare the effects of land use on hydrological response and solute transport. Results show that the characteristics of events and antecedent conditions have a significant influence on TTD and RTD, but in general the RTD of the grassland dominated catchment is concentrated in the shorter time spans and has a higher cumulative TTD, while the forest dominated catchment has a relatively higher response distribution and lower cumulative TTD. The catchment where wetlands concentrate shows a flashier response, but wetlands also appear to prolong transit time.

  10. Integrated response and transit time distributions of watersheds by combining hydrograph separation and long-term transit time modeling

    Directory of Open Access Journals (Sweden)

    M. C. Roa-García

    2010-01-01

    Full Text Available We present a new modeling approach analyzing and predicting the Transit Time Distribution (TTD and the Response Time Distribution (RTD from hourly to annual time scales as two distinct hydrological processes. The model integrates Isotope Hydrograph Separation (IHS and the Instantaneous Unit Hydrograph (IUH approach as a tool to provide a more realistic description of transit and response time of water in catchments. Individual event simulations and parameterizations were combined with long-term baseflow simulation and parameterizations to provide a comprehensive picture of the catchment response for a long time span for the hydraulic and isotopic processes. The proposed method was tested in three Andean headwater catchments to compare the effects of land use on hydrological response and solute transport. Results show that the characteristics of events and antecedent conditions have a significant influence on TTD and RTD, but in general the RTD of the grassland dominated catchment is concentrated in the shorter time spans and has a higher cumulative TTD, while the forest dominated catchment has a relatively longer response distribution and lower cumulative TTD. The catchment where wetlands concentrate shows a flashier response, but wetlands also appear to contribute to prolong transit time.

  11. Duration effect of desflurane anesthesia and its awakening time and arterial concentration in gynecologic patients

    Directory of Open Access Journals (Sweden)

    Tso-Chou Lin

    2013-10-01

    Full Text Available OBJECTIVES: To determine the awakening arterial blood concentration of desflurane and its relationship with the end-tidal concentration during emergence from various durations of general anesthesia. METHOD: In total, 42 American Society of Anesthesiologists physical status class I-II female patients undergoing elective gynecologic surgery were enrolled. General anesthesia was maintained with fixed 6% inspiratory desflurane in 6 l min-1 oxygen until shutoff of the vaporizer at the end of surgery. One milliliter of arterial blood was obtained for desflurane concentration determination by gas chromatography at 20 and 10 minutes before and 0, 5, 10, 15, and 20 minutes after the discontinuation of desflurane and at the time of eye opening upon verbal command, defined as awakening. Concentrations of inspiratory and end-tidal desflurane were simultaneously detected by an infrared analyzer. RESULTS: The mean arterial blood concentration of desflurane was 1.20% at awakening, which correlated with the awakening end-tidal concentration of 0.96%. The mean time from the discontinuation of desflurane to eye opening was 5.2 minutes (SD = 1.6, range 3-10, which was not associated with the duration of anesthesia (60-256 minutes, total fentanyl dose, or body mass index (BMI. CONCLUSIONS: The mean awakening arterial blood concentration of desflurane was 1.20%. The time to awakening was independent of anesthetic duration within four hours. Using well-assisted ventilation, the end-tidal concentration of desflurane was proven to represent the arterial blood concentration during elimination and could be a clinically feasible predictor of emergence from general anesthesia.

  12. Endovascular treatment of acute basilar artery occlusion: time to treatment is crucial

    International Nuclear Information System (INIS)

    Aim: To evaluate the safety and efficacy of multimodal endovascular treatment (EVT) of acute basilar artery occlusion (BAO), including bridging therapy [intravenous thrombolysis (IVT) with subsequent EVT], to compare particular EVT techniques and identify predictors of clinical outcome. Materials and methods: This retrospective, multi-centre study comprised 72 acute ischaemic stroke patients (51 males; mean age 59.1 ± 13.3 years) with radiologically confirmed BAO. The following data were collected: baseline characteristics, risk factors, pre-event antithrombotic treatment, neurological deficit at time of treatment, localization of occlusion, time to therapy, recanalization rate, post-treatment imaging findings. Thirty- and 90-day outcomes were evaluated using the modified Rankin scale with a good clinical outcome defined as 0–3 points. Results: Successful recanalization was achieved in 94.4% patients. Stepwise binary logistic regression analysis identified the presence of arterial hypertension (OR = 0.073 and OR = 0.067, respectively), National Institutes of Health Stroke Scale (NIHSS) at the time of treatment (OR = 0,829 and OR = 0.864, respectively), and time to treatment (OR = 0.556 and OR = 0.502, respectively) as significant independent predictors of 30- and 90-day clinical outcomes. Conclusion: Data from this multicentre study showed that multimodal EVT was an effective recanalization method in acute BAO. Bridging therapy shortens the time to treatment, which was identified as the only modifiable outcome predictor. - Highlights: • Various treatments are being used in recanalization of basilar artery occlusion. • Multimodal endovascular treatment is an effective recanalization method. • Time-to-treatment is the only modifiable outcome predictor. • Bridging therapy shortens time-to-treatment. • Arterial hypertension, neurologic deficit are associated with poor outcome

  13. Time course of arterial remodelling in diameter and wall thickness above and below the lesion after a spinal cord injury

    OpenAIRE

    Dick H J Thijssen; de Groot, Patricia C. E.; van den Bogerd, Arne; Veltmeijer, Matthijs; Cable, N. Timothy; Green, Daniel J.; Hopman, Maria T. E.

    2012-01-01

    Physical inactivity in response to a spinal cord injury (SCI) represents a potent stimulus for conduit artery remodelling. Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by systemic adaptations due to whole body inactivity. Therefore, we assessed the time course of carotid (i.e. above lesion) and common femoral artery (i.e. below lesion) lumen diameter and wall thickness a...

  14. Leave-one-out prediction error of systolic arterial pressure time series under paced breathing

    CERN Document Server

    Ancona, N; Marinazzo, D; Nitti, L; Pellicoro, M; Pinna, G D; Stramaglia, S

    2004-01-01

    In this paper we show that different physiological states and pathological conditions may be characterized in terms of predictability of time series signals from the underlying biological system. In particular we consider systolic arterial pressure time series from healthy subjects and Chronic Heart Failure patients, undergoing paced respiration. We model time series by the regularized least squares approach and quantify predictability by the leave-one-out error. We find that the entrainment mechanism connected to paced breath, that renders the arterial blood pressure signal more regular, thus more predictable, is less effective in patients, and this effect correlates with the seriousness of the heart failure. The leave-one-out error separates controls from patients and, when all orders of nonlinearity are taken into account, alive patients from patients for which cardiac death occurred.

  15. The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation

    CERN Document Server

    Harpsøe, K B W; Hinse, T C; Jørgensen, U G; Mancini, L; Southworth, J; Alsubai, K A; Bozza, V; Browne, P; Burgdorf, M J; Novati, S Calchi; Dodds, P; Dominik, M; Finet, F; Gerner, T; Hundertmark, M; Kains, N; Kerins, E; Liebig, C; Mathiasen, M; Nesvorný, D; Nikolov, N; Penny, M T; Proft, S; Rahvar, S; Ricci, D; Sahu, K C; Scarpetta, G; Schäfer, S; Schönebeck, F; Snodgrass, C; Skottfelt, J; Surdej, J; Tregloan-Reed, J; Wertz, O

    2012-01-01

    Aims: We present 11 high-precision photometric transit observations of the transiting super-Earth planet GJ1214b. Combining these data with observations from other authors, we investigate the ephemeris for possible signs of transit timing variations (TTVs) using a Bayesian approach. Methods: The observations were obtained using telescope-defocusing techniques, and achieve a high precision with random errors in the photometry as low as 1mmag per point. To investigate the possibility of TTVs in the light curve, we calculate the overall probability of a TTV signal using Bayesian methods. Results: The observations are used to determine the photometric parameters and the physical properties of the GJ1214 system. Our results are in good agreement with published values. Individual times of mid-transit are measured with uncertainties as low as 10s, allowing us to reduce the uncertainty in the orbital period by a factor of two. Conclusions: A Bayesian analysis reveals that it is highly improbable that the observed tra...

  16. Transit time instabilities in an inverted fireball. I. Basic properties

    Science.gov (United States)

    Stenzel, R. L.; Gruenwald, J.; Fonda, B.; Ionita, C.; Schrittwieser, R.

    2011-01-01

    A new fireball configuration has been developed which produces vircator-like instabilities. Electrons are injected through a transparent anode into a spherical plasma volume. Strong high-frequency oscillations with period corresponding to the electron transit time through the sphere are observed. The frequency is below the electron plasma frequency, hence does not involve plasma eigenmodes. The sphere does not support electromagnetic eigenmodes at the instability frequency. However, the rf oscillations on the gridded anode create electron bunches which reinforce the grid oscillation after one transit time or rf period, which leads to an absolute instability. Various properties of the instability are demonstrated and differences to the sheath-plasma instability are pointed out, one of which is a relatively high conversion efficiency from dc to rf power. Nonlinear effects are described in a companion paper [R. L. Stenzel et al., Phys. Plasmas 18, 012105 (2011)].

  17. Computational Discrete Time Markov Chain with Correlated Transition Probabilities

    OpenAIRE

    Peerayuth Charnsethikul

    2006-01-01

    This study presents a computational procedure for analyzing statistics of steady state probabilities in a discrete time Markov chain with correlations among their transition probabilities. The proposed model simply uses the first order Taylor's series expansion and statistical expected value properties to obtain the resulting linear matrix equations system. Computationally, the bottleneck is O(n4) but can be improved by distributed and parallel processing. A preliminary computational experien...

  18. Transit Timing Observations from Kepler: VI. Transit Timing Variation Candidates in the First Seventeen Months from Polynomial Models

    CERN Document Server

    Ford, Eric B; Rowe, Jason F; Steffen, Jason H; Barclay, Thomas; Batalha, Natalie M; Borucki, William J; Bryson, Stephen T; Caldwell, Douglas A; Fabrycky, Daniel C; Gautier, Thomas N; Holman, Matthew J; Ibrahim, Khadeejah A; Kjeldsen, Hans; Kinemuchi, Karen; Koch, David G; Lissauer, Jack J; Still, Martin; Tenenbaum, Peter; Uddin, Kamal; Welsh, William

    2012-01-01

    Transit timing variations provide a powerful tool for confirming and characterizing transiting planets, as well as detecting non-transiting planets. We report the results an updated TTV analysis for 822 planet candidates (Borucki et al. 2011; Batalha et al. 2012) based on transit times measured during the first seventeen months of Kepler observations (Rowe et al 2012). We present 35 TTV candidates (4.1% of suitable data sets) based on long-term trends and 153 mostly weaker TTV candidates (18% of suitable data sets) based on excess scatter of TTV measurements about a linear ephemeris. We anticipate that several of these planet candidates could be confirmed and perhaps characterized with more detailed TTV analyses using publicly available Kepler observations. For many others, Kepler has observed a long-term TTV trend, but an extended Kepler mission will be required to characterize the system via TTVs. We find that the occurence rate of planet candidates that show TTVs is significantly increased (~60%-76%) for p...

  19. Lifetime measurements in transitional nuclei by fast electronic scintillation timing

    Science.gov (United States)

    Caprio, M. A.; Zamfir, N. V.; Casten, R. F.; Amro, H.; Barton, C. J.; Beausang, C. W.; Cooper, J. R.; Gürdal, G.; Hecht, A. A.; Hutter, C.; Krücken, R.; McCutchan, E. A.; Meyer, D. A.; Novak, J. R.; Pietralla, N.; Ressler, J. J.; Berant, Z.; Brenner, D. S.; Gill, R. L.; Regan, P. H.

    2002-10-01

    A new generation of experiments studying nuclei in spherical-deformed transition regions has been motivated by the introduction of innovative theoretical approaches to the treatment of these nuclei. The important structural signatures in the transition regions, beyond the basic yrast level properties, involve γ-ray transitions between low-spin, non-yrast levels, and so information on γ-ray branching ratios and absolute matrix elements (or level lifetimes) for these transitions is crucial. A fast electronic scintillation timing (FEST) system [H. Mach, R. L. Gill, and M. Moszyński, Nucl. Instrum. Methods A 280, 49 (1989)], making use of BaF2 and plastic scintillation detectors, has been implemented at the Yale Moving Tape Collector for the measurement of lifetimes of states populated in β^ decay. Experiments in the A100 (Pd, Ru) and A150 (Dy, Yb) regions have been carried out, and a few examples will be presented. Supported by the US DOE under grants and contracts DE-FG02-91ER-40609, DE-FG02-88ER-40417, and DE-AC02-98CH10886 and by the German DFG under grant Pi 393/1.

  20. Smartphone-based Continuous Blood Pressure Measurement Using Pulse Transit Time.

    Science.gov (United States)

    Gholamhosseini, Hamid; Meintjes, Andries; Baig, Mirza; Linden, Maria

    2016-01-01

    The increasing availability of low cost and easy to use personalized medical monitoring devices has opened the door for new and innovative methods of health monitoring to emerge. Cuff-less and continuous methods of measuring blood pressure are particularly attractive as blood pressure is one of the most important measurements of long term cardiovascular health. Current methods of noninvasive blood pressure measurement are based on inflation and deflation of a cuff with some effects on arteries where blood pressure is being measured. This inflation can also cause patient discomfort and alter the measurement results. In this work, a mobile application was developed to collate the PhotoPlethysmoGramm (PPG) waveform provided by a pulse oximeter and the electrocardiogram (ECG) for calculating the pulse transit time. This information is then indirectly related to the user's systolic blood pressure. The developed application successfully connects to the PPG and ECG monitoring devices using Bluetooth wireless connection and stores the data onto an online server. The pulse transit time is estimated in real time and the user's systolic blood pressure can be estimated after the system has been calibrated. The synchronization between the two devices was found to pose a challenge to this method of continuous blood pressure monitoring. However, the implemented continuous blood pressure monitoring system effectively serves as a proof of concept. This combined with the massive benefits that an accurate and robust continuous blood pressure monitoring system would provide indicates that it is certainly worthwhile to further develop this system. PMID:27225558

  1. Smartphone-based Continuous Blood Pressure Measurement Using Pulse Transit Time.

    Science.gov (United States)

    Gholamhosseini, Hamid; Meintjes, Andries; Baig, Mirza; Linden, Maria

    2016-01-01

    The increasing availability of low cost and easy to use personalized medical monitoring devices has opened the door for new and innovative methods of health monitoring to emerge. Cuff-less and continuous methods of measuring blood pressure are particularly attractive as blood pressure is one of the most important measurements of long term cardiovascular health. Current methods of noninvasive blood pressure measurement are based on inflation and deflation of a cuff with some effects on arteries where blood pressure is being measured. This inflation can also cause patient discomfort and alter the measurement results. In this work, a mobile application was developed to collate the PhotoPlethysmoGramm (PPG) waveform provided by a pulse oximeter and the electrocardiogram (ECG) for calculating the pulse transit time. This information is then indirectly related to the user's systolic blood pressure. The developed application successfully connects to the PPG and ECG monitoring devices using Bluetooth wireless connection and stores the data onto an online server. The pulse transit time is estimated in real time and the user's systolic blood pressure can be estimated after the system has been calibrated. The synchronization between the two devices was found to pose a challenge to this method of continuous blood pressure monitoring. However, the implemented continuous blood pressure monitoring system effectively serves as a proof of concept. This combined with the massive benefits that an accurate and robust continuous blood pressure monitoring system would provide indicates that it is certainly worthwhile to further develop this system.

  2. Comparison of noninvasive pulse transit time estimates as markers of blood pressure using invasive pulse transit time measurements as a reference.

    Science.gov (United States)

    Gao, Mingwu; Olivier, N Bari; Mukkamala, Ramakrishna

    2016-05-01

    Pulse transit time (PTT) measured as the time delay between invasive proximal and distal blood pressure (BP) or flow waveforms (invasive PTT [I-PTT]) tightly correlates with BP PTT estimated as the time delay between noninvasive proximal and distal arterial waveforms could therefore permit cuff-less BP monitoring. A popular noninvasive PTT estimate for this application is the time delay between ECG and photoplethysmography (PPG) waveforms (pulse arrival time [PAT]). Another estimate is the time delay between proximal and distal PPG waveforms (PPG-PTT). PAT and PPG-PTT were assessed as markers of BP over a wide physiologic range using I-PTT as a reference. Waveforms for determining I-PTT, PAT, and PPG-PTT through central arteries were measured from swine during baseline conditions and infusions of various hemodynamic drugs. Diastolic, mean, and systolic BP varied widely in each subject (group average (mean ± SE) standard deviation between 25 ± 2 and 36 ± 2 mmHg). I-PTT correlated well with all BP levels (group average R(2) values between 0.86 ± 0.03 and 0.91 ± 0.03). PPG-PTT also correlated well with all BP levels (group average R(2) values between 0.81 ± 0.03 and 0.85 ± 0.02), and its R(2) values were not significantly different from those of I-PTT PAT correlated best with systolic BP (group average R(2) value of 0.70 ± 0.04), but its R(2) values for all BP levels were significantly lower than those of I-PTT (P < 0.005) and PPG-PTT (P < 0.02). The pre-ejection period component of PAT was responsible for its inferior correlation with BP In sum, PPG-PTT was not different from I-PTT and superior to the popular PAT as a marker of BP.

  3. Implantable reflectance pulse transit time blood pressure sensor with oximetry capability

    Science.gov (United States)

    Fiala, J.; Gehrke, R.; Theodor, M.; Bingger, P.; Förster, K.; Heilmann, C.; Beyersdorf, F.; Zappe, H.; Seifert, A.

    2010-04-01

    We present a novel implantable multi-wavelength reflectance sensor for the measurement of blood pressure with pulse transit time (PTT). Continuous long-term monitoring of blood pressure and arterial oxygen saturation is vital for medical diagnostics and the ensuing therapy of cardiovascular diseases. Conventional cuff-based blood pressure monitors do not provide continuous data and put severe constraints on the patients' daily lives. An implantable sensor would eliminate such problems. The new biocompatible sensor is placed subcutaneously on blood perfused tissue. The PTT is calculated by photoplethysmograms and the ECG-signal, that is recorded with intracorporal electrodes. In addition, the sensor detects the arterial oxygen saturation. An ensuing spectralphotometric analysis of the light intensity changes delivers data on the concentration of dysfunctional hemoglobin derivatives. Experimental measurements showed a clear correlation between the estimated PTT and the systolic blood pressure reference. These initial results demonstrate the potential of the sensor as part of an fully implantable sensor system for the longterm-monitoring of cardiovascular parameters.

  4. Time-resolved PIV measurements of the flow field in a stenosed, compliant arterial model

    Science.gov (United States)

    Geoghegan, P. H.; Buchmann, N. A.; Soria, J.; Jermy, M. C.

    2013-05-01

    Compliant (flexible) structures play an important role in several biological flows including the lungs, heart and arteries. Coronary heart disease is caused by a constriction in the artery due to a build-up of atherosclerotic plaque. This plaque is also of major concern in the carotid artery which supplies blood to the brain. Blood flow within these arteries is strongly influenced by the movement of the wall. To study these problems experimentally in vitro, especially using flow visualisation techniques, can be expensive due to the high-intensity and high-repetition rate light sources required. In this work, time-resolved particle image velocimetry using a relatively low-cost light-emitting diode illumination system was applied to the study of a compliant flow phantom representing a stenosed (constricted) carotid artery experiencing a physiologically realistic flow wave. Dynamic similarity between in vivo and in vitro conditions was ensured in phantom construction by matching the distensibility and the elastic wave propagation wavelength and in the fluid system through matching Reynolds ( Re) and Womersley number ( α) with a maximum, minimum and mean Re of 939, 379 and 632, respectively, and a α of 4.54. The stenosis had a symmetric constriction of 50 % by diameter (75 % by area). Once the flow rate reached a critical value, Kelvin-Helmholtz instabilities were observed to occur in the shear layer between the main jet exiting the stenosis and a reverse flow region that occurred at a radial distance of 0.34 D from the axis of symmetry in the region on interest 0-2.5 D longitudinally downstream from the stenosis exit. The instability had an axis-symmetric nature, but as peak flow rate was approached this symmetry breaks down producing instability in the flow field. The characteristics of the vortex train were sensitive not only to the instantaneous flow rate, but also to whether the flow was accelerating or decelerating globally.

  5. Transit timing variations for planets coorbiting in the horseshoe regime

    CERN Document Server

    Vokrouhlicky, David

    2014-01-01

    While not detected yet, pairs of exoplanets in the 1:1 mean motion resonance probably exist. Low eccentricity, near-planar orbits, which in the comoving frame follow the horseshoe trajectories, are one of the possible stable configurations. Here we study transit timing variations produced by mutual gravitational interaction of planets in this orbital architecture, with the goal to develop methods that can be used to recognize this case in observational data. In particular, we use a semi-analytic model to derive parametric constraints that should facilitate data analysis. We show that characteristic traits of the transit timing variations can directly constrain the (i) ratio of planetary masses, and (ii) their total mass (divided by that of the central star) as a function of the minimum angular separation as seen from the star. In an ideal case, when transits of both planets are observed and well characterized, the minimum angular separation can also be inferred from the data. As a result, parameters derived f...

  6. Predictable patterns in planetary transit timing variations and transit duration variations due to exomoons

    CERN Document Server

    Heller, René; Placek, Ben; Angerhausen, Daniel; Agol, Eric

    2016-01-01

    We present new ways to identify single and multiple moons around extrasolar planets using planetary transit timing variations (TTVs) and transit duration variations (TDVs). For planets with one moon, measurements from successive transits exhibit a hitherto undescribed pattern in the TTV-TDV diagram, originating from the stroboscopic sampling of the planet's orbit around the planet-moon barycenter. This pattern is fully determined and analytically predictable after three consecutive transits. The more measurements become available, the more the TTV-TDV diagram approaches an ellipse. For planets with multiple moons in orbital mean motion resonance (MMR), like the Galilean moons, the pattern is much more complex and addressed numerically in this report. Exomoons in MMR can also form closed, predictable TTV-TDV figures if the drift of the moons' pericenters is sufficiently slow. We find that MMR exomoons produce loops in the TTV-TDV diagram and that the number of these loops is equal to the order of the MMR, or t...

  7. Optimizing the search for transiting planets in long time series

    Science.gov (United States)

    Ofir, Aviv

    2014-01-01

    Context. Transit surveys, both ground- and space-based, have already accumulated a large number of light curves that span several years. Aims: The search for transiting planets in these long time series is computationally intensive. We wish to optimize the search for both detection and computational efficiencies. Methods: We assume that the searched systems can be described well by Keplerian orbits. We then propagate the effects of different system parameters to the detection parameters. Results: We show that the frequency information content of the light curve is primarily determined by the duty cycle of the transit signal, and thus the optimal frequency sampling is found to be cubic and not linear. Further optimization is achieved by considering duty-cycle dependent binning of the phased light curve. By using the (standard) BLS, one is either fairly insensitive to long-period planets or less sensitive to short-period planets and computationally slower by a significant factor of ~330 (for a 3 yr long dataset). We also show how the physical system parameters, such as the host star's size and mass, directly affect transit detection. This understanding can then be used to optimize the search for every star individually. Conclusions: By considering Keplerian dynamics explicitly rather than implicitly one can optimally search the BLS parameter space. The presented Optimal BLS enhances the detectability of both very short and very long period planets, while allowing such searches to be done with much reduced resources and time. The Matlab/Octave source code for Optimal BLS is made available. The MATLAB code is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/561/A138

  8. [Comparative study of 2 methods of measuring intestinal transit time].

    Science.gov (United States)

    Vidal-Neira, L; León-Barúa, R

    1981-01-01

    In 20 healthy volunteers, intestinal transit times, obtained following a simple method, recently described, in which a small liquid-containing rubber bag is used as a marker, were compared with the times obtained following, simultaneously, another method, already universally accepted, in which small barium-impregnated pellets are used as markers. The intestinal transit determined with the rubber bag (TTI-B) (14.1 - 79.2 hours; mean +/- s.d.: 42.4 +/- 20.7 hours) were significantly shorter than the times determined with the plastic pellets (TTI) (26.4 - 88.1 hours; mean +/- s.d.: 60.2 +/- 25.5 hours (P less than 0.001). But, TTI-B and TTI correlate closely (r: + 0.86), and, furthermore, TTI-B results may be converted to TTI results with the help of a simple regression equation: TTI (in minutes) = 831 + 1.09 TTI-B (in minutes). After analyzing what has been observed in the present work and in previous works, it was concluded that the new method to measure intestinal transient time using the small rubber bag is reliable and simple, and that it may help to better understand what happens in some important gastrointestinal problems. PMID:7342626

  9. Real-Time Elastography Visualization and Histopathological Characterization of Rabbit Atherosclerotic Carotid Arteries.

    Science.gov (United States)

    Wang, ZhenZhen; Liu, NaNa; Zhang, LiFeng; Li, XiaoYing; Han, XueSong; Peng, YanQing; Dang, MeiZheng; Sun, LiTao; Tian, JiaWei

    2016-01-01

    To evaluate the feasibility of non-invasive vascular real-time elastography imaging (RTE) in visualizing the composition of rabbit carotid atherosclerotic plaque as determined by histopathology, a rabbit model of accelerated carotid atherosclerosis was used. Thirty rabbits were randomly divided into two groups of 15 rabbits each. The first group was fed a cholesterol-rich diet and received balloon-induced injury the left common carotid artery endothelium, whereas the second group only received a cholesterol-rich diet. The rabbits were all examined in vivo with HITACHI non-invasive vascular real-time elastography (Hi-RTE) at baseline and 12 wk, and results from the elastography were compared with American Heart Association histologic classifications. Hi-RTE and the American Heart Association histologic classifications had good agreement, with weighted Cohen's kappa (95% confidence internal) of 0.785 (0.649-0.920). Strains of segmented plaques that were stained in different colors were statistically different (p visualizing normal and atherosclerotic rabbit carotid arteries non-invasively. This affordable and reliable method can be widely applied in research of both animal and human peripheral artery atherosclerosis.

  10. Modelling systematics of ground-based transit photometry I. Implications on transit timing variations

    CERN Document Server

    von Essen, C; Mallonn, M; Tingley, B; Marcussen, M

    2016-01-01

    The transit timing variation technique (TTV) has been widely used to detect and characterize multiple planetary systems. Due to the observational biases imposed mainly by the photometric conditions and instrumentation and the high signal-to-noise required to produce primary transit observations, ground-based data acquired using small telescopes limit the technique to the follow-up of hot Jupiters. However, space-based missions such as Kepler and CoRoT have already revealed that hot Jupiters are mainly found in single systems. Thus, it is natural to question ourselves if we are properly using the observing time at hand carrying out such follow-ups, or if the use of medium-to-low quality transit light curves, combined with current standard techniques of data analysis, could be playing a main role against exoplanetary search via TTVs. The purpose of this work is to investigate to what extent ground-based observations treated with current modelling techniques are reliable to detect and characterize additional pla...

  11. Optimizing the search for transiting planets in long time series

    CERN Document Server

    Ofir, Aviv

    2013-01-01

    Context: Transit surveys, both ground- and space- based, have already accumulated a large number of light curves that span several years. Aims: The search for transiting planets in these long time series is computationally intensive. We wish to optimize the search for both detection and computational efficiencies. Methods: We assume that the searched systems can be well described by Keplerian orbits. We then propagate the effects of different system parameters to the detection parameters. Results: We show that the frequency information content of the light curve is primarily determined by the duty cycle of the transit signal, and thus the optimal frequency sampling is found to be cubic and not linear. Further optimization is achieved by considering duty-cycle dependent binning of the phased light curve. By using the (standard) BLS one is either rather insensitive to long-period planets, or less sensitive to short-period planets and computationally slower by a significant factor of ~330 (for a 3yr long dataset...

  12. The effect of time from last food intake on arterial blood gases: Implication on reference values

    Directory of Open Access Journals (Sweden)

    Zahedpour Anaraki M

    2000-08-01

    Full Text Available Arterial blood gas parameters were analyzed in forty-nine healthy persons (31 males, 18 females to detemine reference values fo these parameters and their relation to the time from last food intake to arterial puncture (T. The mean ± standard deviation of arterial oxygen pressure, arterial carbon dioxide pressure and pH at core body temperature were 84.4±7.0 mmHg (Male: 83.0±6.5, Female: 86.7±73, 37.7±2.8 mmHg (Male: 38.5±2.7, Female: 36.2±2.4 respectively 7.41±0.02 (Male: 7.41±0.02 Female: 7.42±0.03. the mean PCO2 was lower in comparison with most of the studies at sea level. The difference between males and females was significant in PCO2 and PH (P=0.004, P=0.02 respectively but in was not significant in PO2 (P=0.07. The PCO2 and pH had no statistically significant relatioship with age (P=0.42, P=0.25 respectively. The relationship between Po2 with age, PCO2 and T was significant (P=0.02, P=0.017, and P=0.019 respectively. The best linear predictive equation was: Po2= 1.28 AO2-29.4 for T10hours Þ AO2 = 0.21(Baro-47 – (1.2PCO2

  13. Excitation signal's influence on ultrasonic transit time flow meter's performance

    Science.gov (United States)

    Svilainis, L.; Kabisius, P.; Aleksandrovas, A.; Chaziachmetovas, A.

    2012-12-01

    Ultrasonic flow meter performance was analyzed. Ultrasound transit time was used for flow rate estimation. Time of flight was measured using cross correlation processing. Simultaneous channels excitation was used. Ultrasonic signals were excited using low voltage (4V pp) signal generator, received signals were amplified 30 dB and simultaneously acquired by 100 Ms/s 10 bit analog-to-digit converters. Subsample delay estimation was used. Flow rate was varied from 10 l/h to 200 l/h. Measurement channel diameter 8 mm was used. It is complicated to obtain the unbiased reference signal for correlation processing. Various combinations of signals travelling in measurement channel were used for cross-correlation processing. Performance of correlation function and time of flight estimator variance were studied. Variable gain amplifier usually is used for signal dynamic range matching to A/D converter input. Gain influence on time of flight was a subject to study. It has been concluded that gain control introduces systematic errors in time of flight estimator. Influence of the temperature of electronics (pulser, receiver, A/D converter, reference clock etc.) and ultrasonic transducers on the delay estimator was studied. It was concluded that the major temperature-related systematic error comes from the pulser. Performance of the meter was studied when narrowband and spread spectrum signals were used for ultrasound excitation across temperature and flow rate range. It has been concluded that spread spectrum signal allows for better zero flow stability over temperature and lower time of flight variation.

  14. Daylight saving time transitions and acute myocardial infarction.

    Science.gov (United States)

    Čulić, Viktor

    2013-06-01

    Most recently, the possible impact of transitions to and from daylight saving time (DST) on the increased incidence of acute myocardial infarction (AMI) has been suggested. The goal of this report was to analyze independent influence of DST transitions on the incidence of AMI with simultaneous control for the confounding presence of situational triggers such as physical exertion, emotional stress, heavy meals, and sexual intercourse, as well as for other clinical factors. Detailed information was obtained from 2412 patients and included baseline characteristics, working status, exact time of AMI, possible external triggers, cardiovascular risk factors, and prehospital medication. AMI incidence on days after the DST was compared with incidence during control periods and patient characteristics, cardiovascular medication, and circumstances of AMI were evaluated to identify potential risk modifiers. Relative risks of AMI and differences in patient characteristics were expressed through incidence ratios and odds ratios, respectively, with 95% confidence intervals (CIs). Multivariate analysis was performed by using a stepwise multiple regression to assess the independent predictive significance of the characteristics of patients for the AMI occurring in the posttransitional period. The incidence ratio for AMI for the first four workdays after the spring DST transition was 1.29 (95% CI: 1.09-1.49) and the excess was particularly prominent on Monday. In autumn, the incidence ratio for AMI for this 4-d period was 1.44 (95% CI: 1.19-1.69), with peaks on Tuesday and Thursday. The independent predictors for AMI during this period in spring were male sex (p = 0.03) and nonengagement in physical activity (p = 0.02) and there was a trend for the lower risk of incident among those taking calcium antagonists (p = 0.07). In autumn, the predictors were female sex (p = 0.04), current employment (p = 0.006), not taking β-blocker (p = 0.03), and nonengagement in physical activity (p

  15. Data Fusion Based Hybrid Approach for the Estimation of Urban Arterial Travel Time

    Directory of Open Access Journals (Sweden)

    S. P. Anusha

    2012-01-01

    Full Text Available Travel time estimation in urban arterials is challenging compared to freeways and multilane highways. This becomes more complex under Indian conditions due to the additional issues related to heterogeneity, lack of lane discipline, and difficulties in data availability. The fact that most of the urban arterials in India do not employ automatic detectors demands the need for an effective, yet less data intensive way of estimating travel time. An attempt has been made in this direction to estimate total travel time in an urban road stretch using the location based flow data and sparse travel time data obtained using GPS equipped probe vehicles. Three approaches are presented and compared in this study: (1 a combination of input-output analysis for mid-blocks and Highway Capacity Manual (HCM based delay calculation at signals named as base method, (2 data fusion approach which employs Kalman filtering technique (nonhybrid method, and (3 a hybrid data fusion HCM (hybrid DF-HCM method. Data collected from a stretch of roadway in Chennai, India was used for the corroboration. Simulated data were also used for further validation. The results showed that when data quality is assured (simulated data the base method performs better. However, in real field situations, hybrid DF-HCM method outperformed the other methods.

  16. Arterial spin labeling in patients with chic cerebral artery steno-occlusive disease - Correlation with {sup 15}O-PET

    Energy Technology Data Exchange (ETDEWEB)

    Kamano, Hironori; Yoshiura, Takashi; Hiwatashi, Akio; Abe, Koichiro; Yamashita, Koji; Honda, Hiroshi [Dept. of Clinical Radiology, Graduate School of Medical Sciences, Kyushu Univ., Fukuoka (Japan)], e-mail: tsu@radiol.med.kyushu-u.ac.jp; Togao, Osamu [Dept. of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu Univ., Fukuoka (Japan)

    2013-02-15

    Background: Heterogeneity of arterial transit time due to cerebral artery steno-occlusive lesions hampers accurate regional cerebral blood flow measurement by arterial spin labeling (ASL). Purpose: To assess the feasibility of regional cerebral blood flow measurement by ASL with multiple-delay time sampling in patients with steno-occlusive diseases by comparing with positron emission tomography (PET), and to determine whether regional arterial transit time measured by this ASL technique is correlated with regional mean transit time, a PET index of perfusion pressure. Material and Methods: Sixteen patients with steno-occlusive diseases received both ASL and {sup 15}O-PET. The mean regional cerebral blood flow measured by ASL and PET, regional arterial transit time by ASL, and regional mean transit time by PET were obtained by a region-of-interest analysis. Correlation between regional cerebral blood flow by ASL and that by PET, and correlation between regional arterial transit time by ASL and regional mean transit time by PET were tested using Pearson's correlation coefficient for both absolute and relative values. A multivariate regression analysis was performed to test whether regional arterial transit time by ASL was a significant contributor in modeling regional mean transit time by PET after controlling the effect of regional cerebral blood flow by ASL. Results: A significant positive correlation was found between regional cerebral blood flow by ASL and that by PET for both absolute (r = 0.520, P < 0.0001) and relative (r = 0.691, P < 0.0001) values. A significant positive correlation was found between regional arterial transit time by ASL and regional mean transit time by PET both for absolute (r = 0.369, P = 0.0002) and relative (r = 0.443, P < 0.0001) values. The regression analysis revealed that regional arterial transit time by ASL was a significant contributor in modeling regional mean transit time by PET after controlling regional cerebral blood flow by

  17. Time courses of PIVKA-II and AFP levels after hepatic artery embolization and hepatic artery infusion against hepatocellular carcinoma: relation between the time course and tumor necrosis.

    Science.gov (United States)

    Kishi, K; Sonomura, T; Mitsuzane, K; Nishida, N; Kimura, M; Satoh, M; Yamada, R; Kodama, N; Kinoshita, M; Tanaka, H

    1992-01-01

    We examined 35 untreated patients with unresectable hepatocellular carcinoma who exhibited positivity for both plasma PIVKA-II and serum AFP, and studied the weekly course of these markers from the pre-TAE or -HAI period to the third week of treatment. We correlated changes in these markers with the tumor necrosis rate and the time course on X-ray CT images. One week after TAE, the tumor necrosis rate and the time course of PIVKA-II showed a significant correlation (r = 0.7), while the correlation was between the time course of AFP and the tumor necrosis rate was insignificant (r = 0.2). At two and three weeks after TAE, both the time course of AFP and PIVKA-II showed significant correlations with the tumor necrosis rate. In 16 patients with tumor necrosis rates of not less than 90%, the mean of the actual half-life (AHL) of PIVKA-II was 3.2 days, the shortest was 1.83 days, and 75% of all AHLs clustered from two days to four days, while the mean and shortest AHLs of AFP were six days and 2.98 days, respectively, exhibiting a broader distribution. On the other hand, in three out of the nine cases of hepatocellular carcinoma complicated with portal tumor thrombi, PIVKA-II increased after HAI in spite of a reduction in tumor size. It was suggested that the PIVKA-II level requires careful interpretation in cases of portal vein obstruction after intensive hepatic arterial infusion of anticancer agents.

  18. Unbiased computation of transition times by pathway recombination

    International Nuclear Information System (INIS)

    In many systems, the time scales of the microscopic dynamics and macroscopic dynamics of interest are separated by many orders of magnitude. Examples abound, for instance, nucleation, protein folding, and chemical reactions. For these systems, direct simulation of phase space trajectories does not efficiently determine most physical quantities of interest. The past decade has seen the advent of methods circumventing brute force simulation. For most dynamical quantities, these methods all share the drawback of systematical errors. We present a novel method for generating ensembles of phase space trajectories. By sampling small pieces of these trajectories in different phase space domains and piecing them together in a smart way using equilibrium properties, we obtain physical quantities such as transition times. This method does not have any systematical error and is very efficient; the computational effort to calculate the first passage time across a free energy barrier does not increase with the height of the barrier. The strength of the method is shown in the Ising model. Accurate measurements of nucleation times span almost ten orders of magnitude and reveal corrections to classical nucleation theory

  19. Toward a Smartphone Application for Estimation of Pulse Transit Time

    Directory of Open Access Journals (Sweden)

    He Liu

    2015-10-01

    Full Text Available Pulse transit time (PTT is an important physiological parameter that directly correlates with the elasticity and compliance of vascular walls and variations in blood pressure. This paper presents a PTT estimation method based on photoplethysmographic imaging (PPGi. The method utilizes two opposing cameras for simultaneous acquisition of PPGi waveform signals from the index fingertip and the forehead temple. An algorithm for the detection of maxima and minima in PPGi signals was developed, which includes technology for interpolation of the real positions of these points. We compared our PTT measurements with those obtained from the current methodological standards. Statistical results indicate that the PTT measured by our proposed method exhibits a good correlation with the established method. The proposed method is especially suitable for implementation in dual-camera-smartphones, which could facilitate PTT measurement among populations affected by cardiac complications.

  20. Factors influencing stream baseflow transit times in tropical montane watersheds

    Science.gov (United States)

    Muñoz-Villers, Lyssette E.; Geissert, Daniel R.; Holwerda, Friso; McDonnell, Jeffrey J.

    2016-04-01

    Stream water mean transit time (MTT) is a fundamental hydrologic parameter that integrates the distribution of sources, flow paths, and storages present in catchments. However, in the tropics little MTT work has been carried out, despite its usefulness for providing important information on watershed functioning at different spatial scales in (largely) ungauged basins. In particular, very few studies have quantified stream MTTs or have related these to catchment characteristics in tropical montane regions. Here we examined topographic, land use/cover and soil hydraulic controls on baseflow transit times for nested catchments (0.1-34 km2) within a humid mountainous region, underlain by volcanic soil (Andisols) in central Veracruz (eastern Mexico). We used a 2-year record of bi-weekly isotopic composition of precipitation and stream baseflow data to estimate MTT. Land use/cover and topographic parameters (catchment area and form, drainage density, slope gradient and length) were derived from geographic information system (GIS) analysis. Soil water retention characteristics, and depth and permeability of the soil-bedrock interface were obtained from intensive field measurements and laboratory analysis. Results showed that baseflow MTTs ranged between 1.2 and 2.7 years across the 12 study catchments. Overall, MTTs across scales were mainly controlled by catchment slope and the permeability observed at the soil-bedrock interface. In association with topography, catchment form and the depth to the soil-bedrock interface were also identified as important features influencing baseflow MTTs. The greatest differences in MTTs were found both within groups of small (0.1-1.5 km2) and large (14-34 km2) catchments. Interestingly, the longest stream MTTs were found in the headwater cloud forest catchments.

  1. Optimization of the deflagration to detonation transition: reduction of length and time of transition

    Science.gov (United States)

    Sorin, R.; Zitoun, R.; Desbordes, D.

    2006-06-01

    The aim of this experimental investigation is the study of Deflagration to Detonation Transition (DDT) in tubes in order to (i) reduce both run-up distance and time of transition ( L DDT and t DDT) in connection with Pulsed Detonation Engine applications and to (ii) attempt to scale L DDT with λCJ (the detonation cellular structure width). In DDT, the production of turbulence during the long flame run-up can lead to L DDT values of several meters. To shorten L DDT, an experimental set-up is designed to quickly induce highly turbulent initial flow. It consists of a double chamber terminated with a perforated plate of high Blockage Ratio (BR) positioned at the beginning of a 26 mm inner diameter tube containing a “Shchelkin spiral” of BR ≈ 0.5. The study involves stoichiometric reactive mixtures of H2, CH4, C3H8, and C2H4 with oxygen and diluted with N2 in order to obtain the same cell width λCJ≈10 mm at standard conditions. The results show that a shock-flame system propagating with nearly the isobaric speed of sound of combustion products, called the choking regime, is rapidly obtained. This experimental set-up allows a L DDT below 40 cm for the mixtures used and a ratio L DDT/λCJ ranging from 23 to 37. The transition distance seems to depend on the reduced activation energy ( E a/ RT c) and on the normalized heat of reaction ( Q/ a 0 2). The higher these quantities are, the shorter the ratio L DDT/λCJ is.

  2. Impact of changes in systemic vascular resistance on a novel non-invasive continuous cardiac output measurement system based on pulse wave transit time: a report of two cases

    OpenAIRE

    Ishihara, Hironori; Tsutsui, Masato

    2013-01-01

    The inaccuracy of arterial waveform analysis for measuring continuos cardiac output (CCO) associated with changes in systemic vascular resistance (SVR) has been well documented. A new non-invasive continuous cardiac output monitoring system (esCCO) mainly utilizing pulse wave transit time (PWTT) in place of arterial waveform analysis has been developed. However, the trending ability of esCCO to measure cardiac output during changes in SVR remains unclear. After a previous multicenter study on...

  3. Arterial endothelial function measurement method and apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Maltz, Jonathan S; Budinger, Thomas F

    2014-03-04

    A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

  4. Degeneracy in the characterization of non-transiting planets from transit timing variations

    CERN Document Server

    Boué, Gwenaël; Montalto, Marco; Santos, Nuno C

    2012-01-01

    The transit timing variation (TTV) method allows the detection of non-transiting planets through their gravitational perturbations. Since TTVs are strongly enhanced in systems close to mean-motion resonances (MMR), even a low mass planet can produce an observable signal. This technique has thus been proposed to detect terrestrial planets. In this letter, we analyse TTV signals for systems in or close to MMR in order to illustrate the difficulties arising in the determination of planetary parameters. TTVs are computed numerically with an n-body integrator for a variety of systems close to MMR. The main features of these TTVs are also derived analytically. Systems deeply inside MMR do not produce particularly strong TTVs, while those close to MMR generate quasiperiodic TTVs characterised by a dominant long period term and a low amplitude remainder. If the remainder is too weak to be detected, then the signal is strongly degenerate and this prevents the determination of the planetary parameters. Even though an E...

  5. Iterative Bayesian Estimation of Travel Times on Urban Arterials: Fusing Loop Detector and Probe Vehicle Data.

    Science.gov (United States)

    Liu, Kai; Cui, Meng-Ying; Cao, Peng; Wang, Jiang-Bo

    2016-01-01

    On urban arterials, travel time estimation is challenging especially from various data sources. Typically, fusing loop detector data and probe vehicle data to estimate travel time is a troublesome issue while considering the data issue of uncertain, imprecise and even conflicting. In this paper, we propose an improved data fusing methodology for link travel time estimation. Link travel times are simultaneously pre-estimated using loop detector data and probe vehicle data, based on which Bayesian fusion is then applied to fuse the estimated travel times. Next, Iterative Bayesian estimation is proposed to improve Bayesian fusion by incorporating two strategies: 1) substitution strategy which replaces the lower accurate travel time estimation from one sensor with the current fused travel time; and 2) specially-designed conditions for convergence which restrict the estimated travel time in a reasonable range. The estimation results show that, the proposed method outperforms probe vehicle data based method, loop detector based method and single Bayesian fusion, and the mean absolute percentage error is reduced to 4.8%. Additionally, iterative Bayesian estimation performs better for lighter traffic flows when the variability of travel time is practically higher than other periods.

  6. Asymptotic analysis of blood flow in stented arteries: time dependency and direct simulations***

    Directory of Open Access Journals (Sweden)

    Pichon Gostaf Kirill

    2010-12-01

    Full Text Available This work aims to extend in two distinct directions results recently obtained in [10]. In a first step we focus on the possible extension of our results to the time dependent case. Whereas in the second part some preliminary numerical simulations aim to give orders of magnitudes in terms of numerical costs of direct 3D simulations. We consider, in the first part, the time dependent rough problem for a simplified heat equation in a straight channel that mimics the axial velocity under an oscillating pressure gradient. We derive first order approximations with respect to ϵ, the size of the roughness. In order to understand the problem and set up correct boundary layer approximations, we perform a time periodic fourier analysis and check that no frequency can interact with the roughness. We show rigorously on this toy problem that the boundary layers remain stationary in time (independent on the frequency number. Finally we perform numerical tests validating our theoretical approach. In the second part, we determine actual limits, when running three-dimensional blood flow simulations of the non-homogenized stented arteries. We solve the stationary Stokes equations for an artery containing a saccular aneurysm. Consecutive levels of uniform mesh refinement, serve to relate spatial resolution, problem scale, and required computation time. Test computations are presented for femoral side aneurysm, where a simplified ten-wire stent model was placed across the aneurysm throat. We advocate the proposed stent homogenization model, by concluding that an actual computation power is not sufficient to run accurate, direct simulations of a pulsatile flow in stented vessels.

  7. The Anderson transition: time reversal symmetry and universality

    OpenAIRE

    Slevin, Keith; Ohtsuki, Tomi

    1997-01-01

    We report a finite size scaling study of the Anderson transition. Different scaling functions and different values for the critical exponent have been found, consistent with the existence of the orthogonal and unitary universality classes which occur in the field theory description of the transition. The critical conductance distribution at the Anderson transition has also been investigated and different distributions for the orthogonal and unitary classes obtained.

  8. Female Employment and Timing of Births Decisions: A Multiple State Transition Model

    OpenAIRE

    Bloemen, H.G.; A.S. Kalwij

    1996-01-01

    In this paper we estimate a multiple state transition model, describing transitions into maternity and labor market transitions for women.Each state is characterized by two components: the labor market state and the maternity state. This enables us to investigate to disentangle the effects of socio-economic variables on the timing of births and on labor market transitions.We find that the transition intensities into maternity are significantly higher for non-employed women than for employed w...

  9. Diabetes patients show different time-course of myocardial perfusion improvement after coronary artery bypass grafting

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. J.; Seok, J. W.; Eo, J. S. [Seoul National University Hospital, Seoul (Korea, Republic of)] (and others)

    2005-07-01

    Diabetes mellitus is an independent risk factor of cardiovascular disease. Diabetes is known to cause microangiopathy. The microangiopathy is hardly detectable on the coronary angiography. Myocardial perfusion imaging shows the resultant perfusion status which reflects the microangiopathy. For patients who underwent revascularization, the microangiopathy could affect the myocardial perfusion improvement. Diabetes patients probably experience the different myocardial perfusion improvement as compared to the non-diabetes patients although they have similar angiographic findings. The aim of this study is to find out whether there is a time-course difference of perfusion improvement between the diabetes and non diabetes patients who showed patent angiographic findings after coronary artery grafting surgery (CABG). A total of 129 patients who underwent coronary artery bypass grafting surgery were enrolled in this study. Myocardial SPECTs performed at previous, short-term (3 month), and mid-term (1 year) to CABG. One-year follow up angiography was done 411{+-}121 days after surgery. Graft patency was determined according to the FitzGibbon et al. Segments were assigned to vascular territories using a 20 segment model. The segments of excellent patency were included in this study. Time course differences of concerned segments were analyzed using RMANOVA. The number of segments enrolled was 764 of diabetes and 1083 of non-diabetes. At short-term follow up, reversibility score was 2.8{+-}8.1% in diabetes and 0.3{+-}7.5% in non-diabetes. At long-term follow up, reversibility score was 1.8{+-}8.0% in diabetes and 0.1{+-}7.3% in non-diabetes. The time-course of reversibility score was significantly different between the diabetes and non diabetes (p<0.001) Diabetic segments showed high residual reversibility score than non-diabetic segments after CABG although the angiographic finding was patent in both groups. This result is maybe attributable to microangiopathy induced by

  10. A Gaussian Model-Based Probabilistic Approach for Pulse Transit Time Estimation.

    Science.gov (United States)

    Jang, Dae-Geun; Park, Seung-Hun; Hahn, Minsoo

    2016-01-01

    In this paper, we propose a new probabilistic approach to pulse transit time (PTT) estimation using a Gaussian distribution model. It is motivated basically by the hypothesis that PTTs normalized by RR intervals follow the Gaussian distribution. To verify the hypothesis, we demonstrate the effects of arterial compliance on the normalized PTTs using the Moens-Korteweg equation. Furthermore, we observe a Gaussian distribution of the normalized PTTs on real data. In order to estimate the PTT using the hypothesis, we first assumed that R-waves in the electrocardiogram (ECG) can be correctly identified. The R-waves limit searching ranges to detect pulse peaks in the photoplethysmogram (PPG) and to synchronize the results with cardiac beats--i.e., the peaks of the PPG are extracted within the corresponding RR interval of the ECG as pulse peak candidates. Their probabilities of being the actual pulse peak are then calculated using a Gaussian probability function. The parameters of the Gaussian function are automatically updated when a new pulse peak is identified. This update makes the probability function adaptive to variations of cardiac cycles. Finally, the pulse peak is identified as the candidate with the highest probability. The proposed approach is tested on a database where ECG and PPG waveforms are collected simultaneously during the submaximal bicycle ergometer exercise test. The results are promising, suggesting that the method provides a simple but more accurate PTT estimation in real applications. PMID:25420274

  11. The mass of the Mars-sized exoplanet Kepler-138 b from transit timing

    OpenAIRE

    Jontof-Hutter, Daniel; Rowe, Jason F.; Lissauer, Jack J.; Fabrycky, Daniel C.; Ford, Eric B.

    2015-01-01

    Extrasolar planets that pass in front of their host star (transit) cause a temporary decrease in the apparent brightness of the star once per orbit, providing a direct measure of the planet's size and orbital period. In some systems with multiple transiting planets, the times of the transits are measurably affected by the gravitational interactions between neighbouring planets. In favorable cases, the departures from Keplerian orbits implied by the observed transit times permit planetary mass...

  12. Transitional flow in intracranial aneurysms - a space and time refinement study below the Kolmogorov scales using Lattice Boltzmann Method

    CERN Document Server

    Jain, Kartik; Mardal, Kent-Andre

    2015-01-01

    Most Computational Fluid Dynamics (CFD) studies of hemodynamics in intracranial aneurysms are based on the assumption of laminar flow due to a relatively low (below 500) parent artery Reynolds number. A few studies have recently demonstrated the occurrence of transitional flow in aneurysms, but these studies employed special finite element schemes tailored to capture transitional nature of flow. In this study we investigate the occurrence of transition using a standard Lattice Boltzmann method (LBM). The LBM is used because of its computational efficiency, which in the present study allowed us to perform simulations at a higher resolution than has been done in the context of aneurysms before. The high space-time resolutions of 8{\\mu}m and 0.11 {\\mu}s resulted in nearly one billion cells and 9 million time steps per second and allowed us to quantify the turbulent kinetic energy at resolutions below the Kolmogorov scales. We perform an in-depth space and time refinement study on 2 aneurysms; one was previously ...

  13. Timing is everything : along the fossil fuel transition pathway.

    Energy Technology Data Exchange (ETDEWEB)

    Kobos, Peter Holmes; Walker, La Tonya Nicole; Malczynski, Leonard A.

    2013-10-01

    People save for retirement throughout their career because it is virtually impossible to save all you'll need in retirement the year before you retire. Similarly, without installing incremental amounts of clean fossil, renewable or transformative energy technologies throughout the coming decades, a radical and immediate change will be near impossible the year before a policy goal is set to be in place. Therefore, our research question is,To meet our desired technical and policy goals, what are the factors that affect the rate we must install technology to achieve these goals in the coming decades?' Existing models do not include full regulatory constraints due to their often complex, and inflexible approaches to solve foroptimal' engineering instead ofrobust' and multidisciplinary solutions. This project outlines the theory and then develops an applied software tool to model the laboratory-to-market transition using the traditional technology readiness level (TRL) framework, but develops subsequent and a novel regulatory readiness level (RRL) and market readiness level (MRL). This tool uses the ideally-suited system dynamics framework to incorporate feedbacks and time delays. Future energy-economic-environment models, regardless of their programming platform, may adapt this software model component framework ormodule' to further vet the likelihood of new or innovative technology moving through the laboratory, regulatory and market space. The prototype analytical framework and tool, called the Technology, Regulatory and Market Readiness Level simulation model (TRMsim) illustrates the interaction between technology research, application, policy and market dynamics as they relate to a new or innovative technology moving from the theoretical stage to full market deployment. The initial results that illustrate the model's capabilities indicate for a hypothetical technology, that increasing the key driver

  14. Gastrointestinal mean transit times in young and middle-aged healthy subjects

    DEFF Research Database (Denmark)

    Graff, J; Brinch, K; Madsen, Jan Lysgård

    2001-01-01

    To investigate the effects of age and gender on gastric, small intestinal and colonic mean transit times, a study was conducted in 32 healthy volunteers: eight young women (22-30 years), eight young men (20-28 years), eight middle-aged women (43-51 years) and eight middle-aged men (38-53 years...... unaffected by age, but middle-aged women had a significantly slower colonic transit than young women. We therefore conclude that both age and gender have to be considered when reference values for gastric, small intestinal and colonic mean transit times have to be established......., small intestinal and colonic mean transit times were calculated. The gastric, small intestinal and colonic mean transit times were significantly longer in women. Ageing was shown to accelerate the gastric and small intestinal transit significantly. In the group of men the colonic mean transit time was...

  15. Effects of cuff inflation and deflation on pulse transit time measured from ECG and multi-wavelength PPG.

    Science.gov (United States)

    Liu, Jing; Li, Yao; Ding, Xiao-Rong; Dai, Wen-Xuan; Zhang, Yuan-Ting

    2015-08-01

    Pulse transit time (PTT), which refers to the time it takes a pulse wave to travel between two arterial sites is a promising index for cuff-less blood pressure (BP) estimation, as well as non-invasive assessment of arterial functions. However, it has not been investigated whether PTTs measured from ECG and different wavelength PPG are equally affected by the arterial status. Furthermore, comparison between the changes of different PTTs can provide enlightenment on the hardware implementation of the PTT-based BP estimation method. This work mainly studied the changes of PTTs calculated from electrocardiogram (ECG) and multi-wavelength photoplethysmogram (PPG) after exerting cuff pressure on the upper arm. A four-channel PPG acquisition system was developed to collect the multi-wavelength PPG signals of red, yellow, green and blue light at the fingertip simultaneously. Ten subjects participated in the experiment and their PTTs measured from different PPG and ECG signals before and after exerting cuff pressure were compared. This study found that within one minute after the four-minute cuff inflation and deflation process, the PTT measured from ECG and yellow PPG experienced a significant increase (p0.9) compared with that before exerting cuff pressure. This indicates that PTTs calculated from different wavelength PPG have different recoverability from smooth muscle relaxation. Another interesting finding is that the PTT calculated from ECG and yellow PPG had a strong correlation (|r|>0.7) with the time difference between yellow PPG and other PPG signals, which implies the potential of the time difference between yellow PPG and other PPGs as a complementary to PTT-based model for blood pressure estimation. PMID:26737652

  16. Assessment of chronic constipation: colon transit time versus defecography

    Energy Technology Data Exchange (ETDEWEB)

    Prokesch, R.W. E-mail: rupert.prokesch@univie.ac.at; Breitenseher, M.J.; Kettenbach, J.; Herbst, F.; Maier, A.; Lechner, G.; Mahieu, P

    1999-12-01

    Objective: The aim of this study was to determine the value of radiological colon transit time (CTT) measurements in relation to defecography (DFG) in chronically constipated patients. Materials and methods: In 30 patients with chronic constipation, total and segmental CTT was determined using radiopaque markers. In all of these patients defecography (DFG) was obtained. The patients were divided into three groups: In group I, 11 patients were classified with idiopathic constipation based on low stool frequency, normal DFG, or absence of symptoms of abnormal defecation. In group II, ten patients with rectal intussusception were diagnosed by DFG. In group III, there were nine patients with rectal prolapse or spastic pelvic floor syndrome, based on results of DFG. Results: Group I, idiopathic constipation (n=11), showed increased total CTT (mean, 93 h) and segmental CTT (right colon, 33 h (36%), left colon, 31 h (33%), rectosigmoid, 29 h (31%)). In group II, intussusception (n=10), patients had normal mean total CTT (54 h) and a relative decrease in rectosigmoid CTT (mean, 13 h (24%)). In group III (n=9), rectal prolapse (n=5) or spastic pelvic floor syndrome (n=4), patients showed elevated total (mean, 167 h) and rectosigmoidal CTT (mean, 95 h (57%)). Mean total CTT was significantly different between groups I and II and between groups II and III, and mean rectosigmoidal CTT was significantly different between all three groups (P<0.05). Conclusion: The use of total and rectosigmoidal CTT helps to identify the underlying pathophysiology of chronic constipation. Furthermore CTT helps to identify patients, who may benefit from DFG.

  17. Feasibility study of MR time-resolved imaging of contrast kinetics sequence in evaluation of the dorsalis pedis artery and the first dorsal metatarsal artery

    International Nuclear Information System (INIS)

    Objective: To investigate the feasibility of MR angiography of the dorsalis pedis artery (DPA), the first dorsal metatarsal artery (FDMA) and the branches at the first toe web by three-dimensional time-resolved imaging of contrast kinetics (TRICKS) sequence. Methods: Forty three patients with suspected or known soft tissue diseases of the ankle and foot were examined retrospectively by MR TRICKS sequence. Two experienced radiologists independently evaluated the visualization performance of DPA, FDMA and its branches with maximum intensity projection. Kappa analysis was performed for the image evaluation of the two radiologists. Consensus scores were obtained if the two radiologists had different scores. Clinical classification of FDMA was carried out for patients with scores equal to, or more than 2 points after imaging evaluation. FDMA was categorized according to its location (superficial, intramuscular, infra-muscular, absent), diameter (large, medium and small) and branching pattern at the toe web (ramifying type, main trunk type and fine small branch). Results: The scoring results of the two radiologists indicated a high agreement (Kappa value =0.895, P<0.05). TRICKS images can clearly show the arterial filling of DPA, FDMA and its branches. The final consensus scores were as follows: 8 patients had 4 grade and 22 patients 3 grade, 8 patients 2 grade and 5 patients 1 grade. Clinical classification of FDMA for 38 patients (arterial scales ≥2 point): (1) Location: superficial (8 patients), intramuscular (23 patients), intramuscular (7 patients); (2) Diameter at the midpoint of FDMA: large (2 patients), medium (25 patients), and small (11 patients); (3) Branching pattern at the toe web: ramifying type (11 patients), main trunk type (5 patients), fine branch (14 patients). Conclusion: MR TRICKS sequences are valuable in the evaluation of the DPA and FDMA and its branches, which can provide useful anatomical information for classification of FDMA. (authors)

  18. Telemedicine-supported transition of stable coronary artery disease patients from tertiary to primary health care facilities: protocol for a randomized non-inferiority trial

    OpenAIRE

    Batista, Joanna d’Arc Lyra; Furtado, Mariana Vargas; Katz, Natan; Agostinho, Milena Rodrigues; Neto, Brasil Silva; Harzheim, Erno; Polanczyk, Carisi Anne

    2016-01-01

    Background Many Brazilian patients with complex diseases who are treated in tertiary referral clinics have been stable for long periods. The main needs of these patients involve monitoring of risk factors and review of drug prescriptions, which could be satisfactorily done in primary care facilities. The goal of this protocol is to evaluate the safety and effectiveness of telemedicine services to support the transition of patients with stable chronic coronary artery disease from the tertiary ...

  19. Functional real-time optoacoustic imaging of middle cerebral artery occlusion in mice.

    Directory of Open Access Journals (Sweden)

    Moritz Kneipp

    Full Text Available BACKGROUND AND PURPOSE: Longitudinal functional imaging studies of stroke are key in identifying the disease progression and possible therapeutic interventions. Here we investigate the applicability of real-time functional optoacoustic imaging for monitoring of stroke progression in the whole brain of living animals. MATERIALS AND METHODS: The middle cerebral artery occlusion (MCAO was used to model stroke in mice, which were imaged preoperatively and the occlusion was kept in place for 60 minutes, after which optoacoustic scans were taken at several time points. RESULTS: Post ischemia an asymmetry of deoxygenated hemoglobin in the brain was observed as a region of hypoxia in the hemisphere affected by the ischemic event. Furthermore, we were able to visualize the penumbra in-vivo as a localized hemodynamically-compromised area adjacent to the region of stroke-induced perfusion deficit. CONCLUSION: The intrinsic sensitivity of the new imaging approach to functional blood parameters, in combination with real time operation and high spatial resolution in deep living tissues, may see it become a valuable and unique tool in the development and monitoring of treatments aimed at suspending the spread of an infarct area.

  20. Improving perfusion quantification in arterial spin labeling for delayed arrival times by using optimized acquisition schemes

    Energy Technology Data Exchange (ETDEWEB)

    Kramme, Johanna [Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen (Germany); Univ. Bremen (Germany). Faculty of Physics and Electronics; Gregori, Johannes [mediri GmbH, Heidelberg (Germany); Diehl, Volker [Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen (Germany); ZEMODI (Zentrum fuer morderne Diagnostik), Bremen (Germany); Madai, Vince I.; Sobesky, Jan [Charite-Universitaetsmedizin Berlin (Germany). Center for Stroke Research Berlin (CSB); Charite-Universitaetsmedizin Berlin (Germany). Dept. of Neurology; Samson-Himmelstjerna, Frederico C. von [Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen (Germany); Charite-Universitaetsmedizin Berlin (Germany). Center for Stroke Research Berlin (CSB); Charite-Universitaetsmedizin Berlin (Germany). Dept. of Neurology; Lentschig, Markus [ZEMODI (Zentrum fuer morderne Diagnostik), Bremen (Germany); Guenther, Matthias [Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen (Germany); Univ. Bremen (Germany). Faculty of Physics and Electronics; mediri GmbH, Heidelberg (Germany)

    2015-07-01

    The improvement in Arterial Spin Labeling (ASL) perfusion quantification, especially for delayed bolus arrival times (BAT), with an acquisition redistribution scheme mitigating the T1 decay of the label in multi-TI ASL measurements is investigated. A multi inflow time (TI) 3D-GRASE sequence is presented which adapts the distribution of acquisitions accordingly, by keeping the scan time constant. The MR sequence increases the number of averages at long TIs and decreases their number at short TIs and thus compensating the T1 decay of the label. The improvement of perfusion quantification is evaluated in simulations as well as in-vivo in healthy volunteers and patients with prolonged BATs due to age or steno-occlusive disease. The improvement in perfusion quantification depends on BAT. At healthy BATs the differences are small, but become larger for longer BATs typically found in certain diseases. The relative error of perfusion is improved up to 30% at BATs > 1500 ms in comparison to the standard acquisition scheme. This adapted acquisition scheme improves the perfusion measurement in comparison to standard multi-TI ASL implementations. It provides relevant benefit in clinical conditions that cause prolonged BATs and is therefore of high clinical relevance for neuroimaging of steno-occlusive diseases.

  1. Colonic transit time relates to bacterial metabolism and mucosal turnover in the human gut

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Hansen, Lea Benedicte Skov; Bahl, Martin Iain;

    Little is known about how colonic transit time relates to human colonic metabolism, and its importance for host health, although stool consistency, a proxy for colonic transit time, has recently been negatively associated with gut microbial richness. To address the relationships between colonic...... transit time and the gut microbial composition and metabolism, we assessed the colonic transit time of 98 subjects using radiopaque markers, and profiled their gut microbiota by16S rRNA gene sequencingand their urine metabolome by ultra performance liquid chromatography mass spectrometry. Based...... on correlation analyses,we show that colonic transit time is associated with overall gutmicrobial composition, diversity and metabolism. A relatively prolonged colonic transit time associates with high microbial species richness and a shift in colonic metabolismfrom carbohydrate fermentation to protein...

  2. Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System

    DEFF Research Database (Denmark)

    Gregersen, Tine; Haase, Anne-Mette; Schlageter, Vincent;

    2015-01-01

    not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects. METHODS: Fifteen healthy volunteers......BACKGROUND/AIMS: The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has.......5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0...

  3. On a Possibility of Phase Transitions in the Geometric Structure of Space-Time

    OpenAIRE

    Bogoslovsky, G. Yu.; Goenner, H. F.

    1998-01-01

    It is shown that space-time may be not only in a state which is described by Riemann geometry but also in states which are described by Finsler geometry. Transitions between various metric states of space-time have the meaning of phase transitions in its geometric structure. These transitions together with the evolution of each of the possible metric states make up the general picture of space-time manifold dynamics.

  4. Transit Timing Observations from Kepler: III. Confirmation of 4 Multiple Planet Systems by a Fourier-Domain Study of Anti-correlated Transit Timing Variations

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Fabrycky, Daniel C.; /Lick Observ.; Ford, Eric B.; /Florida U.; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Holman, Matthew J.; /Harvard-Smithsonian Ctr. Astrophys.; Lissauer, Jack J.; /NASA, Ames; Rowe, Jason F.; /SETI Inst., Mtn. View /NASA, Ames; Ragozzine, Darin; /Harvard-Smithsonian Ctr. Astrophys.; Welsh, William F.; /Caltech; Borucki, William J.; /NASA, Ames /UC, Santa Barbara

    2012-01-01

    We present a method to confirm the planetary nature of objects in systems with multiple transiting exoplanet candidates. This method involves a Fourier-domain analysis of the deviations in the transit times from a constant period that result from dynamical interactions within the system. The combination of observed anticorrelations in the transit times and mass constraints from dynamical stability allow us to claim the discovery of four planetary systems, Kepler-25, Kepler-26, Kepler-27 and Kepler-28, containing eight planets and one additional planet candidate.

  5. Transit Timing Observations from Kepler: III. Confirmation of 4 Multiple Planet Systems by a Fourier-Domain Study of Anti-correlated Transit Timing Variations

    CERN Document Server

    Steffen, Jason H; Ford, Eric B; Carter, Joshua A; Desert, Jean-Michel; Fressin, Francois; Holman, Matthew J; Lissauer, Jack J; Moorhead, Althea V; Rowe, Jason F; Ragozzine, Darin; Welsh, William F; Batalha, Natalie M; Borucki, William J; Buchhave, Lars A; Bryson, Steve; Caldwell, Douglas A; Charbonneau, David; Ciardi, David R; Cochran, William D; Endl, Michael; Everett, Mark E; Gautier, Thomas N; Gilliland, Ron L; Girouard, Forrest R; Jenkins, Jon M; Horch, Elliott; Howell, Steve B; Isaacson, Howard; Klaus, Todd C; Koch, David G; Latham, David W; Li, Jie; Lucas, Philip; MacQueen, Phillip J; Marcy, Geoffrey W; McCauliff, Sean; Middour, Christopher K; Morris, Robert L; Mullally, Fergal R; Quinn, Samuel N; Quintana, Elisa V; Shporer, Avi; Still, Martin; Tenenbaum, Peter; Thompson, Susan E; Twicken, Joseph D; Van Cleve, Jeffery

    2012-01-01

    We present a method to confirm the planetary nature of objects in systems with multiple transiting exoplanet candidates. This method involves a Fourier-Domain analysis of the deviations in the transit times from a constant period that result from dynamical interactions within the system. The combination of observed anti-correlations in the transit times and mass constraints from dynamical stability allow us to claim the discovery of four planetary systems Kepler-25, Kepler-26, Kepler-27, and Kepler-28, containing eight planets and one additional planet candidate.

  6. Decreasing Transition Times in Elementary School Classrooms: Using Computer-Assisted Instruction to Automate Intervention Components

    Science.gov (United States)

    Hine, Jeffrey F.; Ardoin, Scott P.; Foster, Tori E.

    2015-01-01

    Research suggests that students spend a substantial amount of time transitioning between classroom activities, which may reduce time spent academically engaged. This study used an ABAB design to evaluate the effects of a computer-assisted intervention that automated intervention components previously shown to decrease transition times. We examined…

  7. Measurement of vascular water transport in human subjects using time-resolved pulsed arterial spin labelling.

    Science.gov (United States)

    Bibic, Adnan; Knutsson, Linda; Schmidt, Anders; Henningsson, Erik; Månsson, Sven; Abul-Kasim, Kasim; Åkeson, Jonas; Gunther, Matthias; Ståhlberg, Freddy; Wirestam, Ronnie

    2015-08-01

    Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non-compartmental model, and no measurements need to be added to a common time-resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one-dimensional general Langevin equation as the starting point, and as a Fokker-Planck differential equation for the averaged distribution of labelled spins at the end point, which takes into account the effects of flow and dispersion of labelled water by the pseudorandom nature of the microvasculature and the transcapillary permeability. Multi-inversion time (multi-TI) ASL data were acquired in 14 healthy subjects on two occasions in a test-retest design, using a pulsed ASL sequence and three-dimensional gradient and spin echo (3D-GRASE) readout. Based on an error analysis to predict the size of a region of interest (ROI) required to obtain reasonably precise parameter estimates, data were analysed in two relatively large ROIs, i.e. the occipital lobe (OC) and the insular cortex (IC). The average values of CTT in OC were 260 ± 60 ms in the first experiment and 270 ± 60 ms in the second experiment. The corresponding IC values were 460 ± 130 ms and 420 ± 139 ms, respectively. Information related to the water transfer time may be important for diagnostics and follow-up of cerebral conditions or diseases characterised by a disrupted blood-brain barrier or disturbed capillary blood flow. PMID:26147641

  8. Photobleaching of arterial fluorescent compounds: characterization of elastin, collagen and cholesterol time-resolved spectra during prolonged ultraviolet irradiation.

    Science.gov (United States)

    Marcu, L; Grundfest, W S; Maarek, J M

    1999-06-01

    To study the photobleaching of the main fluorescent compounds of the arterial wall, we repeatedly measured the time-resolved fluorescence of elastin, collagen and cholesterol during 560 s of excitation with nitrogen laser pulses. Three fluence rate levels were used: 0.72, 7.25 and 21.75 microW/mm2. The irradiation-related changes of the fluorescence intensity and of the time-resolved fluorescence decay constants were characterized for the emission at 390, 430 and 470 nm. The fluorescence intensity at 390 nm decreased by 25-35% when the fluence delivered was 4 mJ/mm2, a common value in fluorescence studies of the arterial wall. Cholesterol fluorescence photobleached the most, and elastin fluorescence photobleached the least. Photobleaching was most intense at 390 nm and least intense at 470 nm such that the emission spectra of the three compounds were markedly distorted by photobleaching. The time-resolved decay constants and the fluorescence lifetime were not altered by irradiation when the fluence was below 4 mJ/mm2. The spectral distortions associated with photobleaching complicate the interpretation of arterial wall fluorescence in terms of tissue content in elastin, collagen and cholesterol. Use of the time-dependent features of the emission that are not altered by photobleaching should increase the accuracy of arterial wall analysis by fluorescence spectroscopy. PMID:10378012

  9. Transit-time flow measurement as a predictor of coronary bypass graft failure at one year angiographic follow-up

    DEFF Research Database (Denmark)

    Lehnert, Per; Møller, Christian H; Damgaard, Sune;

    2015-01-01

    BACKGROUND: Transit-time flow measurement (TTFM) is a commonly used intraoperative method for evaluation of coronary artery bypass graft (CABG) anastomoses. This study was undertaken to determine whether TTFM can also be used to predict graft patency at one year postsurgery. METHODS: Three hundred...... forty-five CABG patients with intraoperative graft flow measurements and one year angiographic follow-up were analyzed. Graft failure was defined as more than 50% stenosis including the "string sign." Logistic regression analysis was used to analyze the risk of graft failure after one year based.......00], p = 0.059) and AUC of 59.9%. There were no significant relationships between TTFM and graft failure in other graft types or graft configurations. CONCLUSION: The TTFM method has good discriminative ability for assessing the risk of graft failure in certain graft types within the first year after...

  10. Off-pump and on-pump coronary artery bypass surgery:time to move on

    Institute of Scientific and Technical Information of China (English)

    Shahzad G Raja

    2004-01-01

    @@ To the editor: Chen and colleagues,1 and the editorial staff of the Chinese Medical Journal, deserve much credit for carrying out and publishing a prospective comparative study of on-pump and off-pump coronary artery bypass (OPCAB) surgery in 300 patients with triple-vessel coronary artery disease. Although this study is limited by non-randomization and selection bias yet contrary to the previously published prospective, randomized studies by Van Dijk et al,2 and Ascione et al,3 the patient population of this study is more representative of current coronary artery surgery practices. Even more important is the conclusion that OPCAB can be applied to patients with triple-vessel coronary artery disease and "in experienced hands" can achieve similar completeness of revascularization and similar early surgical results.

  11. Time course and recovery of arterial blood gases during exacerbations in adults with Cystic Fibrosis.

    LENUS (Irish Health Repository)

    Waterhouse, D F

    2012-02-01

    INTRODUCTION: Hypoxia and hypercapnia are closely linked to morbidity and mortality in patients with Cystic Fibrosis (CF). The aims of this study were to describe the changes in blood gases during and following an acute pulmonary exacerbation in adults with CF. METHODS: We performed a prospective observational study of patients with CF admitted for management of an acute exacerbation. Blood gas and spirometric analysis was performed on admission, throughout the treatment period, and 31 days after discharge (day 45). RESULTS: At presentation, eight of nineteen patients had evidence of either hypoxia (PaO(2)<8 kPa) and\\/or hypercapnia (PaCO(2)>6.6 kPa). Blood gas parameters stabilized following two weeks of intravenous antibiotic therapy, with little difference evident in between treatment completion and subsequent review following discharge. Hypercapnia reversed in three patients, with persistent hypercapnia evident in two patients. CONCLUSION: In our study group, hypoxemia and hypercapnia were frequently observed at presentation of the acute exacerbation. Blood gases stabilized following two weeks of intravenous antibiotic therapy, with arterial PCO(2) one month following hospital discharge generally similar to that at time of discharge.

  12. Stopped-flow technique for transit time measurement in a gas jet

    Energy Technology Data Exchange (ETDEWEB)

    Rengan, K.; Lin, J.; Lim, T.; Meyer, R.A.; Harrell, J.

    1985-12-15

    A stopped-flow technique for the measurement of transit time of reaction products in a gas jet is described. The method involved establishing the gas flow through the jet system when the reactor is operating steadily and allowing the pressure to reach equilibrium values. The gas flow is stopped by means of electrically operated valves. The transit-time measurement is achieved by opening the valves and initiating the multiscanning of total activity simultaneously. The value obtained agrees well with the transit time measured by pulsing the reactor. The stopped-flow technique allows on-line measurement of transit time in any gas jet system where the physical transportation time is the major component of the transit time. This technique is especially useful for systems installed in reactors which do not have pulsing capability. (orig.).

  13. The physical origins of transit time measurements for rapid, single cell mechanotyping.

    Science.gov (United States)

    Nyberg, Kendra D; Scott, Michael B; Bruce, Samuel L; Gopinath, Ajay B; Bikos, Dimitri; Mason, Thomas G; Kim, Jin Woong; Choi, Hong Sung; Rowat, Amy C

    2016-08-16

    The mechanical phenotype or 'mechanotype' of cells is emerging as a potential biomarker for cell types ranging from pluripotent stem cells to cancer cells. Using a microfluidic device, cell mechanotype can be rapidly analyzed by measuring the time required for cells to deform as they flow through constricted channels. While cells typically exhibit deformation timescales, or transit times, on the order of milliseconds to tens of seconds, transit times can span several orders of magnitude and vary from day to day within a population of single cells; this makes it challenging to characterize different cell samples based on transit time data. Here we investigate how variability in transit time measurements depends on both experimental factors and heterogeneity in physical properties across a population of single cells. We find that simultaneous transit events that occur across neighboring constrictions can alter transit time, but only significantly when more than 65% of channels in the parallel array are occluded. Variability in transit time measurements is also affected by the age of the device following plasma treatment, which could be attributed to changes in channel surface properties. We additionally investigate the role of variability in cell physical properties. Transit time depends on cell size; by binning transit time data for cells of similar diameters, we reduce measurement variability by 20%. To gain further insight into the effects of cell-to-cell differences in physical properties, we fabricate a panel of gel particles and oil droplets with tunable mechanical properties. We demonstrate that particles with homogeneous composition exhibit a marked reduction in transit time variability, suggesting that the width of transit time distributions reflects the degree of heterogeneity in subcellular structure and mechanical properties within a cell population. Our results also provide fundamental insight into the physical underpinnings of transit measurements

  14. Impact of Timing of Eptifibatide Administration on Preprocedural Infarct-Related Artery Patency in Acute STEMI Patients Undergoing Primary PCI

    OpenAIRE

    Dharma, Surya; Firdaus, Isman; Danny, Siska Suridanda; Juzar, Dafsah A.; Wardeh, Alexander J.; Jukema, J Wouter; van der Laarse, Arnoud

    2014-01-01

    The appropriate timing of eptifibatide initiation for acute ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) remains unclear. This study aimed to analyze the impact of timing of eptifibatide administration on infarct-related artery (IRA) patency in STEMI patients undergoing primary PCI. Acute STEMI patients who underwent primary PCI (n = 324) were enrolled in this retrospective study; 164 patients received eptifibatide bol...

  15. Model of transit time for SiGe HBT Collector junction depletion-layer

    Institute of Scientific and Technical Information of China (English)

    Hu Hui-Yong; Zhang He-Ming; Dai Xian-Ying; Jia Xin-Zhang; Cui Xiao-Ying; Wang Wei; Ou Jian-Feng; Wang Xi-Yuan

    2005-01-01

    The transit time through collector junction depletion-layer is an important parameter that influences AC gain and frequency performance. In SiGe heterojunction bipolar transistor (HBT) collector junction, the depletion-layer width is given in three cases. The models of collector depletion-layer transit time, considering the collector current densities and base extension effect, are established and simulated using MATLAB. The influence of the different collector j unction bias voltage, collector concentration of As or P dopant and collector width on collector junction transit time is quantitatively studied. When the collector junction bias voltage, collector doping concentration and collector width are large, the transit time is quite long. And, from the results of simulations, the influence of the collector depletion-layer transit time on frequency performance is considerable in SiGe HBT with a thin base, so it could not be ignored.

  16. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Hansen, Lea Benedicte Skov; Bahl, Martin Iain;

    2016-01-01

    Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit...... time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation...... to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness...

  17. Time-Series Interactions of Gene Expression, Vascular Growth and Hemodynamics during Early Embryonic Arterial Development.

    Science.gov (United States)

    Goktas, Selda; Uslu, Fazil E; Kowalski, William J; Ermek, Erhan; Keller, Bradley B; Pekkan, Kerem

    2016-01-01

    The role of hemodynamic forces within the embryo as biomechanical regulators for cardiovascular morphogenesis, growth, and remodeling is well supported through the experimental studies. Furthermore, clinical experience suggests that perturbed flow disrupts the normal vascular growth process as one etiology for congenital heart diseases (CHD) and for fetal adaptation to CHD. However, the relationships between hemodynamics, gene expression and embryonic vascular growth are poorly defined due to the lack of concurrent, sequential in vivo data. In this study, a long-term, time-lapse optical coherence tomography (OCT) imaging campaign was conducted to acquire simultaneous blood velocity, pulsatile micro-pressure and morphometric data for 3 consecutive early embryonic stages in the chick embryo. In conjunction with the in vivo growth and hemodynamics data, in vitro reverse transcription polymerase chain reaction (RT-PCR) analysis was performed to track changes in transcript expression relevant to histogenesis and remodeling of the embryonic arterial wall. Our non-invasive extended OCT imaging technique for the microstructural data showed continuous vessel growth. OCT data coupled with the PIV technique revealed significant but intermitted increases in wall shear stress (WSS) between first and second assigned stages and a noticeable decrease afterwards. Growth rate, however, did not vary significantly throughout the embryonic period. Among all the genes studied, only the MMP-2 and CASP-3 expression levels remained unchanged during the time course. Concurrent relationships were obtained among the transcriptional modulation of the genes, vascular growth and hemodynamics-related changes. Further studies are indicated to determine cause and effect relationships and reversibility between mechanical and molecular regulation of vasculogenesis. PMID:27552150

  18. Time Resolved Phase Transitions via Dynamic Transmission Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Reed, B W; Armstrong, M R; Blobaum, K J; Browning, N D; Burnham, A K; Campbell, G H; Gee, R; Kim, J S; King, W E; Maiti, A; Piggott, W T; Torralva, B R

    2007-02-22

    The Dynamic Transmission Electron Microscope (DTEM) project is developing an in situ electron microscope with nanometer- and nanosecond-scale resolution for the study of rapid laser-driven processes in materials. We report on the results obtained in a year-long LDRD-supported effort to develop DTEM techniques and results for phase transitions in molecular crystals, reactive multilayer foils, and melting and resolidification of bismuth. We report the first in situ TEM observation of the HMX {beta}-{delta} phase transformation in sub-{micro}m crystals, computational results suggesting the importance of voids and free surfaces in the HMX transformation kinetics, and the first electron diffraction patterns of intermediate states in fast multilayer foil reactions. This project developed techniques which are applicable to many materials systems and will continue to be employed within the larger DTEM effort.

  19. Investigation of Timing to Switch Control Mode in Powered Knee Prostheses during Task Transitions.

    Directory of Open Access Journals (Sweden)

    Fan Zhang

    Full Text Available Current powered prosthetic legs require switching control modes according to the task the user is performing (e.g. level-ground walking, stair climbing, walking on slopes, etc.. To allow prosthesis users safely and seamlessly transition between tasks, it is critical to determine when to switch the prosthesis control mode during task transitions. Our previous study defined critical timings for different types of task transitions in ambulation; however, it is unknown whether it is the unique timing that allows safe and seamless transitions. The goals of this study were to (1 systematically investigate the effects of mode switch timing on the prosthesis user's performance in task transitions, and (2 identify appropriate timing to switch the prosthesis control mode so that the users can seamlessly transition between different locomotion tasks. Five able-bodied (AB and two transfemoral (TF amputee subjects were tested as they wore a powered knee prosthesis. The prosthesis control mode was switched manually at various times while the subjects performed different types of task transitions. The subjects' task transition performances were evaluated by their walking balance and success in performing seamless task transitions. The results demonstrated that there existed a time window within which switching the prosthesis control mode neither interrupted the subjects' task transitions nor disturbed their walking balance. Therefore, the results suggested the control mode switching of a lower limb prosthesis can be triggered within an appropriate time window instead of a specific timing or an individual phase. In addition, a generalized criterion to determine the appropriate mode switch timing was proposed. The outcomes of this study could provide important guidance for future designs of neurally controlled powered knee prostheses that are safe and reliable to use.

  20. SOPHIE velocimetry of Kepler transit candidates. X. KOI-142 c: first radial velocity confirmation of a non-transiting exoplanet discovered by transit timing

    Science.gov (United States)

    Barros, S. C. C.; Díaz, R. F.; Santerne, A.; Bruno, G.; Deleuil, M.; Almenara, J.-M.; Bonomo, A. S.; Bouchy, F.; Damiani, C.; Hébrard, G.; Montagnier, G.; Moutou, C.

    2014-01-01

    The exoplanet KOI-142b (Kepler-88b) shows transit timing variations (TTVs) with a semi-amplitude of ~12 h, which earned it the nickname "king of transit variations". Only the transit of planet b was detected in the Kepler data with an orbital period of ~10.92 days and a radius of ~0.36 RJup. The TTVs together with the transit duration variations of KOI-142b were analysed recently, finding a unique solution for a companion-perturbing planet. An outer non-transiting companion was predicted, KOI-142c, with a mass of 0.626 ± 0.03 MJup and a period of 22.3397-0.0018+0.0021 days, which is close to the 2:1 mean-motion resonance with the inner transiting planet. We report an independent confirmation of KOI-142c using radial velocity observations with the SOPHIE spectrograph at the Observatoire de Haute-Provence. We derive an orbital period of 22.10 ± 0.25 days and a minimum planetary mass of 0.760.16+0.32 MJup, both in good agreement with the predictions by previous transit timing analysis. Therefore, this is the first radial velocity confirmation of a non-transiting planet discovered with TTVs, providing an independent validation of the TTVs technique. Based on observations collected with the NASA Kepler satellite and with the SOPHIE spectrograph on the 1.93-m telescope at Observatoire de Haute-Provence (CNRS), France.Tables 2 and 3 are available in electronic form at http://www.aanda.org

  1. Scintigraphic determination of gastrointestinal transit times. A comparison with breath hydrogen and radiologic methods

    DEFF Research Database (Denmark)

    Madsen, J L; Larsen, N E; Hilsted, J;

    1991-01-01

    in eight healthy subjects. Neither mean small-intestinal nor mean orocaecal transit times of the radiolabelled marker were correlated with the magnitude of hydrogen peak, hydrogen peak time, or the area under hydrogen curve. No correlation was noted between whole-gut transit time of the radiolabelled......A scintigraphic method for determination of gastrointestinal transit times was compared with the breath hydrogen test and a multiple-bolus, single-radiograph technique. A close temporal association was found between the caecal appearance of radioactivity and the onset of breath hydrogen excretion...

  2. Community walking speed, sedentary or lying down time, and mortality in peripheral artery disease.

    Science.gov (United States)

    McDermott, Mary M; Guralnik, Jack M; Ferrucci, Luigi; Tian, Lu; Kibbe, Melina R; Greenland, Philip; Green, David; Liu, Kiang; Zhao, Lihui; Wilkins, John T; Huffman, Mark D; Shah, Sanjiv J; Liao, Yihua; Gao, Ying; Lloyd-Jones, Donald M; Criqui, Michael H

    2016-04-01

    We studied whether slower community walking speed and whether greater time spent lying down or sleeping were associated with higher mortality in people with lower extremity peripheral artery disease (PAD). Participants with an ankle-brachial index (ABI) walking speed outside their home and the number of hours they spent lying down or sleeping per day. Cause of death was adjudicated using death certificates and medical record review. Analyses were adjusted for age, sex, race, comorbidities, ABI, and other confounders. Of 1314 PAD participants, 189 (14.4%) died, including 63 cardiovascular disease (CVD) deaths. Mean follow-up was 34.9 months ± 18.1. Relative to average or normal pace (2-3 miles/hour), slower walking speed was associated with greater CVD mortality: no walking at all: hazard ratio (HR) = 4.17, 95% confidence interval (CI) = 1.46-11.89; casual strolling (0-2 miles/hour): HR = 2.24, 95% CI = 1.16-4.32; brisk or striding (>3 miles/hour): HR = 0.55, 95% CI = 0.07-4.30. These associations were not significant after additional adjustment for the six-minute walk. Relative to sleeping or lying down for 8-9 hours, fewer or greater hours sleeping or lying down were associated with higher CVD mortality: 4-7 hours: HR = 2.08, 95% CI = 1.06-4.05; 10-11 hours: HR = 4.07, 95% CI = 1.86-8.89; ⩾ 12 hours: HR = 3.75, 95% CI = 1.47-9.62. These associations were maintained after adjustment for the six-minute walk. In conclusion, slower walking speed outside the home and less than 8 hours or more than 9 hours lying down per day are potentially modifiable behaviors associated with increased CVD mortality in patients with PAD. PMID:26873873

  3. The Use of Transit Timing to Detect Extrasolar Planets with Masses as Small as Earth

    OpenAIRE

    Holman, Matthew J.; Murray, Norman W.

    2004-01-01

    Future surveys for transiting extrasolar planets, including the space-based mission Kepler (Borucki et al 2003), are expected to detect hundreds of Jovian mass planets and tens of terrestrial mass planets. For many of these newly discovered planets, the intervals between successive transits will be measured with an accuracy of 0.1--100 minutes. We show that these timing measurements will allow for the detection of additional planets in the system (not necessarily transiting), via their gravit...

  4. Measuring Acoustic Wave Transit Time in Furnace Based on Active Acoustic Source Signal

    Institute of Scientific and Technical Information of China (English)

    Zhen Luo; Feng Tian; Xiao-Ping Sun

    2007-01-01

    Accurate measurement of transit time for acoustic wave between two sensors installed on two sides of a furnace is a key to implementing the temperature field measurement technique based on acoustical method. A new method for measuring transit time of acoustic wave based on active acoustic source signal is proposed in this paper, which includes the followings: the time when the acoustic source signal arrives at the two sensors is measured first; then, the difference of two arriving time arguments is computed, thereby we get the transit time of the acoustic wave between two sensors installed on the two sides of the furnace. Avoiding the restriction on acoustic source signal and background noise, the new method can get the transit time of acoustic wave with higher precision and stronger ability of resisting noise interference.

  5. No Timing Variations Observed in Third Transit of Snow-Line Exoplanet Kepler-421b

    CERN Document Server

    Dalba, Paul A

    2016-01-01

    We observed Kepler-421 during the anticipated third transit of the snow-line exoplanet Kepler-421b in order to constrain the existence and extent of transit timing variations (TTVs). Previously, the Kepler Spacecraft only observed two transits of Kepler-421b leaving the planet's transit ephemeris unconstrained. Our visible light, time-series observations from the 4.3-meter Discovery Channel Telescope were designed to capture pre-transit baseline and the partial transit of Kepler-421b barring significant TTVs. We use the light curves to assess the probabilities of various transit models using both the posterior odds ratio and the Bayesian Information Criterion (BIC) and find that a transit model with no TTVs is favored to 3.6-sigma confidence. These observations suggest that Kepler-421b is either alone in its system or is only experiencing minor dynamic interactions with an unseen companion. With the Kepler-421b ephemeris constrained, we calculate future transit times and discuss the opportunity to characteriz...

  6. Solid volume fraction estimation of bone:marrow replica models using ultrasound transit time spectroscopy.

    Science.gov (United States)

    Wille, Marie-Luise; Langton, Christian M

    2016-02-01

    The acceptance of broadband ultrasound attenuation (BUA) for the assessment of osteoporosis suffers from a limited understanding of both ultrasound wave propagation through cancellous bone and its exact dependence upon the material and structural properties. It has recently been proposed that ultrasound wave propagation in cancellous bone may be described by a concept of parallel sonic rays; the transit time of each ray defined by the proportion of bone and marrow propagated. A Transit Time Spectrum (TTS) describes the proportion of sonic rays having a particular transit time, effectively describing the lateral inhomogeneity of transit times over the surface aperture of the receive ultrasound transducer. The aim of this study was to test the hypothesis that the solid volume fraction (SVF) of simplified bone:marrow replica models may be reliably estimated from the corresponding ultrasound transit time spectrum. Transit time spectra were derived via digital deconvolution of the experimentally measured input and output ultrasonic signals, and compared to predicted TTS based on the parallel sonic ray concept, demonstrating agreement in both position and amplitude of spectral peaks. Solid volume fraction was calculated from the TTS; agreement between true (geometric calculation) with predicted (computer simulation) and experimentally-derived values were R(2)=99.9% and R(2)=97.3% respectively. It is therefore envisaged that ultrasound transit time spectroscopy (UTTS) offers the potential to reliably estimate bone mineral density and hence the established T-score parameter for clinical osteoporosis assessment. PMID:26455950

  7. Solid volume fraction estimation of bone:marrow replica models using ultrasound transit time spectroscopy.

    Science.gov (United States)

    Wille, Marie-Luise; Langton, Christian M

    2016-02-01

    The acceptance of broadband ultrasound attenuation (BUA) for the assessment of osteoporosis suffers from a limited understanding of both ultrasound wave propagation through cancellous bone and its exact dependence upon the material and structural properties. It has recently been proposed that ultrasound wave propagation in cancellous bone may be described by a concept of parallel sonic rays; the transit time of each ray defined by the proportion of bone and marrow propagated. A Transit Time Spectrum (TTS) describes the proportion of sonic rays having a particular transit time, effectively describing the lateral inhomogeneity of transit times over the surface aperture of the receive ultrasound transducer. The aim of this study was to test the hypothesis that the solid volume fraction (SVF) of simplified bone:marrow replica models may be reliably estimated from the corresponding ultrasound transit time spectrum. Transit time spectra were derived via digital deconvolution of the experimentally measured input and output ultrasonic signals, and compared to predicted TTS based on the parallel sonic ray concept, demonstrating agreement in both position and amplitude of spectral peaks. Solid volume fraction was calculated from the TTS; agreement between true (geometric calculation) with predicted (computer simulation) and experimentally-derived values were R(2)=99.9% and R(2)=97.3% respectively. It is therefore envisaged that ultrasound transit time spectroscopy (UTTS) offers the potential to reliably estimate bone mineral density and hence the established T-score parameter for clinical osteoporosis assessment.

  8. Validation of transit-time flowmetry for chronic measurements of regional blood flow in resting and exercising rats

    Directory of Open Access Journals (Sweden)

    S.L. Amaral

    1997-07-01

    Full Text Available The objective of the present study was to validate the transit-time technique for long-term measurements of iliac and renal blood flow in rats. Flow measured with ultrasonic probes was confirmed ex vivo using excised arteries perfused at varying flow rates. An implanted 1-mm probe reproduced with accuracy different patterns of flow relative to pressure in freely moving rats and accurately quantitated the resting iliac flow value (on average 10.43 ± 0.99 ml/min or 2.78 ± 0.3 ml min-1 100 g body weight-1. The measurements were stable over an experimental period of one week but were affected by probe size (resting flows were underestimated by 57% with a 2-mm probe when compared with a 1-mm probe and by anesthesia (in the same rats, iliac flow was reduced by 50-60% when compared to the conscious state. Instantaneous changes of iliac and renal flow during exercise and recovery were accurately measured by the transit-time technique. Iliac flow increased instantaneously at the beginning of mild exercise (from 12.03 ± 1.06 to 25.55 ± 3.89 ml/min at 15 s and showed a smaller increase when exercise intensity increased further, reaching a plateau of 38.43 ± 1.92 ml/min at the 4th min of moderate exercise intensity. In contrast, exercise-induced reduction of renal flow was smaller and slower, with 18% and 25% decreases at mild and moderate exercise intensities. Our data indicate that transit-time flowmetry is a reliable method for long-term and continuous measurements of regional blood flow at rest and can be used to quantitate the dynamic flow changes that characterize exercise and recovery

  9. The mass of the Mars-sized exoplanet Kepler-138 b from transit timing

    CERN Document Server

    Jontof-Hutter, Daniel; Lissauer, Jack J; Fabrycky, Daniel C; Ford, Eric B

    2015-01-01

    Extrasolar planets that pass in front of their host star (transit) cause a temporary decrease in the apparent brightness of the star once per orbit, providing a direct measure of the planet's size and orbital period. In some systems with multiple transiting planets, the times of the transits are measurably affected by the gravitational interactions between neighbouring planets. In favorable cases, the departures from Keplerian orbits implied by the observed transit times permit planetary masses to be measured, which is key to determining bulk densities. Characterizing rocky planets is particularly difficult, since they are generally smaller and less massive than gaseous planets. Thus, few exoplanets near Earth's size have had their masses measured. Here we report the sizes and masses of three planets orbiting Kepler-138, a star much fainter and cooler than the Sun. We measure the mass of the Mars-sized inner planet based on on the transit times of its neighbour and thereby provide the first density measuremen...

  10. A model for temporal resolution of multidetector computed tomography of coronary arteries in relation to rotation time, heart rate and reconstruction algorithm

    NARCIS (Netherlands)

    Greuter, M. J. W.; Flohr, T.; van Ooijen, P. M. A.; Oudkerk, M.

    2007-01-01

    A model is presented that describes the image quality of coronary arteries with multidetector computer tomography. The results are discussed in the context of rotation time of the scanner, heart rate, and number of sectors used in the acquisition process. The blurring of the coronary arteries was ca

  11. Transit timing observations from Kepler. VI. Potentially interesting candidate systems from fourier-based statistical tests

    DEFF Research Database (Denmark)

    Steffen, J.H.; Ford, E.B.; Rowe, J.F.;

    2012-01-01

    We analyze the deviations of transit times from a linear ephemeris for the Kepler Objects of Interest (KOI) through quarter six of science data. We conduct two statistical tests for all KOIs and a related statistical test for all pairs of KOIs in multi-transiting systems. These tests identify...

  12. Pointwise upper estimates for transition probability of continuous time random walks on graphs

    OpenAIRE

    Chen, Xinxing

    2013-01-01

    Let $X$ be a continuous time random walk on a weighted graph. Given the on-diagonal upper bounds of transition probabilities at two vertices $x_1$ and $x_2$, we use an adapted metric initiated by Davies, and obtain Gaussian upper estimates for the off-diagonal transition probability $P_{x_1}(X_t=x_2)$.

  13. Markov Model of Wind Power Time Series UsingBayesian Inference of Transition Matrix

    DEFF Research Database (Denmark)

    Chen, Peiyuan; Berthelsen, Kasper Klitgaard; Bak-Jensen, Birgitte;

    2009-01-01

    This paper proposes to use Bayesian inference of transition matrix when developing a discrete Markov model of a wind speed/power time series and 95% credible interval for the model verification. The Dirichlet distribution is used as a conjugate prior for the transition matrix. Three discrete Markov...

  14. Numerical assessment of time-domain methods for the estimation of local arterial pulse wave speed.

    Science.gov (United States)

    Alastruey, Jordi

    2011-03-15

    A local estimation of pulse wave speed c, an important predictor of cardiovascular events, can be obtained at arterial locations where simultaneous measurements of blood pressure (P) and velocity (U), arterial diameter (D) and U, flow rate (Q) and cross-sectional area (A), or P and D are available, using the PU-loop, sum-of-squares (∑(2)), lnDU-loop, QA-loop or new D(2)P-loop methods. Here, these methods were applied to estimate c from numerically generated P, U, D, Q and A waveforms using a visco-elastic one-dimensional model of the 55 larger human systemic arteries in normal conditions. Theoretical c were calculated from the parameters of the model. Estimates of c given by the loop methods were closer to theoretical values and more uniform within each arterial segment than those obtained using the ∑(2). The smaller differences between estimates and theoretical values were obtained using the D(2)P-loop method, with root-mean-square errors (RMSE) smaller than 0.18 ms(-1), followed by averaging the two c given by the PU- and lnDU-loops (RMSE elastic effects were small and nearby junctions were well-matched for forward-travelling waves. The ∑(2) performed better at proximal locations. PMID:21211799

  15. First-time viewers' comprehension of films: bridging shot transitions.

    Science.gov (United States)

    Ildirar, Sermin; Schwan, Stephan

    2015-02-01

    Which perceptual and cognitive prerequisites must be met in order to be able to comprehend a film is still unresolved and a controversial issue. In order to gain some insights into this issue, our field experiment investigates how first-time adult viewers extract and integrate meaningful information across film cuts. Three major types of commonalities between adjacent shots were differentiated, which may help first-time viewers with bridging the shots: pictorial, causal, and conceptual. Twenty first-time, 20 low-experienced and 20 high-experienced viewers from Turkey were shown a set of short film clips containing these three kinds of commonalities. Film clips conformed also to the principles of continuity editing. Analyses of viewers' spontaneous interpretations show that first-time viewers indeed are able to notice basic pictorial (object identity), causal (chains of activity), as well as conceptual (links between gaze direction and object attention) commonalities between shots due to their close relationship with everyday perception and cognition. However, first-time viewers' comprehension of the commonalities is to a large degree fragile, indicating the lack of a basic notion of what constitutes a film. PMID:24654735

  16. What do we know about the timing of fertility transitions in Europe?

    Science.gov (United States)

    Guinnane, T W; Okun, B S; Trussell, J

    1994-02-01

    The Princeton project on the decline of fertility in Europe (the European Fertility Project) suggested that this historical fertility transition occurred virtually simultaneously in a wide variety of economic and social environments. This finding has been cited widely as evidence for an innovation/diffusion view of fertility transitions. We demonstrate that the demographic methods used to date the fertility transition in Europe--primarily Ig, and (to a lesser extent) the Coale-Trussell M&m indices--may fail to detect the initial stages of a fertility transition and therefore cannot be used as the basis for strong statements about the timing of transitions. We review these measurement problems and their implications for the current understanding of the European fertility transition.

  17. Transition in adolescents across time, disease and gender

    DEFF Research Database (Denmark)

    Aagaard, Hanne; Ludvigsen, Mette Spliid; Svanholm, Jette Rolf

    interview with the adolescent at outpatient clinics at Aarhus University Hospital. Follow-up is planned at 15 and 18 years of age. A comparative approach is employed to show central characteristics across time, disease and gender. Results: Results from analysis inspired by Ricoeur's phenomenological...

  18. On time-resolved approach for phonon assisted interband transitions

    Science.gov (United States)

    Klotins, E.

    2015-03-01

    Photoexcited dynamics of electrons and holes in two-band dielectric, with special emphasis on back reaction of phonons are developed by combining the quantum electrodynamics and Baker-Campbell-Hausdorff (BCH) canonical transformation. These methods create an explicit time-domain representation of photoinduced processes and contribute in unifying phonon-assisted description of distribution functions of electron and hole quasiparticles for the description of observable effects of photoinduced processes in dielectrics.

  19. Clinical application of magnetic resonance angiography for coronary arteries. Correlation with conventional angiography and evaluation of imaging time

    Energy Technology Data Exchange (ETDEWEB)

    Nitatori, Toshiaki; Hanaoka, Hideto; Yoshino, Ayako [Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine] [and others

    1995-08-01

    Magnetic resonance angiography (MRA) of the coronary arteries is a particularly difficult task because of the small size of the vessels and cardio-respiratory motion. The authors describe a method of performing of ultrafast MRA of the coronary arteries with a standard MR system and body coil. Each image was obtained within a single breath hold by `segmented Turbo FLASH` sequences using an electro-cardiography gate. Clinical application was performed in 20 patients with ischemic heart disease, and a comparison was made with conventional coronary angiography. The imaging time was shortened significantly by our methods. The diagnosis was made by at least two different images to avoid false positives. The results indicated a good correlation between MRA and conventional angiography. (author).

  20. Effects of unsteadiness and non-Newtonian rheology on blood flow through a tapered time-variant stenotic artery

    Directory of Open Access Journals (Sweden)

    A. Zaman

    2015-03-01

    Full Text Available A two-dimensional model is used to analyze the unsteady pulsatile flow of blood through a tapered artery with stenosis. The rheology of the flowing blood is captured by the constitutive equation of Carreau model. The geometry of the time-variant stenosis has been used to carry out the present analysis. The flow equations are set up under the assumption that the lumen radius is sufficiently smaller than the wavelength of the pulsatile pressure wave. A radial coordinate transformation is employed to immobilize the effect of the vessel wall. The resulting partial differential equations along with the boundary and initial conditions are solved using finite difference method. The dimensionless radial and axial velocity, volumetric flow rate, resistance impedance and wall shear stress are analyzed for normal and diseased artery with particular focus on variation of these quantities with non-Newtonian parameters.

  1. Determination of transit time in the hydraulic system of the San Gaban II hydroelectric plant

    International Nuclear Information System (INIS)

    This work determines the hydraulic behavior of waters from different lakes (Pauchinta, Parinajota and Suytococha) which feed the San Gaban II Hydroelectric Plant across the Corani and Macusani rivers through the transit time to the headwater dam

  2. Transit timing, depth, and duration variation in exoplanet TrES-2?

    Directory of Open Access Journals (Sweden)

    Vaňko M.

    2011-02-01

    Full Text Available We report on our ongoing search for timing, duration, and depth variations in the exoplanet TrES-2. In Raetz et al. (2009 we already presented ten different transits obtained at the University Observatory Jena. Between November 2008 and August 2010 twelve additional transits could be observed. The timing, depth and duration of each individual event was analyzed and is presented here.

  3. A Matheuristic for the Liner Shipping Network Design Problem with Transit Time Restrictions

    DEFF Research Database (Denmark)

    Brouer, Berit Dangaard; Desaulniers, Guy; Karsten, Christian Vad;

    2015-01-01

    We present a mathematical model for the liner shipping network design problem with transit time restrictions on the cargo flow. We extend an existing matheuristic for the liner shipping network design problem to consider transit time restrictions. The matheuristic is an improvement heuristic, where...... on the benchmark suite LINER-LIB are reported, showing profitable networks for most instances. We provide insights on causes for rejecting demand and the average speed per vessel class in the solutions obtained....

  4. The Cover Time of Deterministic Random Walks for General Transition Probabilities

    OpenAIRE

    Shiraga, Takeharu

    2016-01-01

    The deterministic random walk is a deterministic process analogous to a random walk. While there are some results on the cover time of the rotor-router model, which is a deterministic random walk corresponding to a simple random walk, nothing is known about the cover time of deterministic random walks emulating general transition probabilities. This paper is concerned with the SRT-router model with multiple tokens, which is a deterministic process coping with general transition probabilities ...

  5. Transit Timing Observations from Kepler: VII. Potentially interesting candidate systems from Fourier-based statistical tests

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Ford, Eric B.; /Florida U.; Rowe, Jason F.; /NASA, Ames /SETI Inst., Mtn. View; Fabrycky, Daniel C.; /Lick Observ.; Holman, Matthew J.; /Harvard-Smithsonian Ctr. Astrophys.; Welsh, William F.; /San Diego State U., Astron. Dept.; Borucki, William J.; /NASA, Ames; Batalha, Natalie M.; /San Jose State U.; Bryson, Steve; /NASA, Ames; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Ciardi, David R.; /Caltech /NASA, Ames /SETI Inst., Mtn. View

    2012-01-01

    We analyze the deviations of transit times from a linear ephemeris for the Kepler Objects of Interest (KOI) through Quarter six (Q6) of science data. We conduct two statistical tests for all KOIs and a related statistical test for all pairs of KOIs in multi-transiting systems. These tests identify several systems which show potentially interesting transit timing variations (TTVs). Strong TTV systems have been valuable for the confirmation of planets and their mass measurements. Many of the systems identified in this study should prove fruitful for detailed TTV studies.

  6. Scintigraphic Small Intestinal Transit Time and Defaecography in Patients with J-Pouch

    Directory of Open Access Journals (Sweden)

    Mie Dilling Kjaer

    2015-10-01

    Full Text Available Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. The objective of this study was to evaluate the results of scintigraphic intestinal transit time and defaecography compared to the results of pouch function, mucosal condition and a questionnaire on quality of life (QoL. This cross-sectional study included 21 patients. Scintigraphic transit time and defaecography was determined with the use of Tc-99m. Pouch function was assessed by number of bowel movements, pouch volume, and continence. Pouch mucosal condition was evaluated by endoscopy and histology. Median transit time was 189 min (105–365. Median ejection fraction at defaecography (EF was 49% (3–77 and 62% (17–98 after first and second defecation. Median pouch volume was 223 mL (100–360. A median daily stool frequency of nine (4–25 was reported and three (14% patients suffered from daytime incontinence. No patients had symptomatic or endoscopic pouchitis; however, the histology showed unspecific inflammation in 19 (90% patients. There was no correlation between transit time, evacuation fraction (EF and pouch function in univariate analysis. However, we found a high body mass index (BMI and a low bowel movement frequency to be associated with a longer transit time by multivariate analysis. Scintigraphic determination of transit time and defaecography are feasible methods in patients with ileal pouch anal anastomosis, but the clinical relevance is yet doubtful.

  7. Chronic Obstructive Pulmonary Disease Subtypes. Transitions over Time

    Science.gov (United States)

    Esteban, Cristóbal; Arostegui, Inmaculada; Aburto, Myriam; Moraza, Javier; Quintana, José M.; García-Loizaga, Amaia; Basualdo, Luis V.; Aramburu, Amaia; Aizpiri, Susana; Uranga, Ane; Capelastegui, Alberto

    2016-01-01

    Background Although subtypes of chronic obstructive pulmonary disease are recognized, it is unknown what happens to these subtypes over time. Our objectives were to assess the stability of cluster-based subtypes in patients with stable disease and explore changes in clusters over 1 year. Methods Multiple correspondence and cluster analysis were used to evaluate data collected from 543 stable patients included consecutively from 5 respiratory outpatient clinics. Results Four subtypes were identified. Three of them, A, B, and C, had marked respiratory profiles with a continuum in severity of several variables, while the fourth, subtype D, had a more systemic profile with intermediate respiratory disease severity. Subtype A was associated with less dyspnea, better health-related quality of life and lower Charlson comorbidity scores, and subtype C with the most severe dyspnea, and poorer pulmonary function and quality of life, while subtype B was between subtypes A and C. Subtype D had higher rates of hospitalization the previous year, and comorbidities. After 1 year, all clusters remained stable. Generally, patients continued in the same subtype but 28% migrated to another cluster. Together with movement across clusters, patients showed changes in certain characteristics (especially exercise capacity, some variables of pulmonary function and physical activity) and changes in outcomes (quality of life, hospitalization and mortality) depending on the new cluster they belonged to. Conclusions Chronic obstructive pulmonary disease clusters remained stable over 1 year. Most patients stayed in their initial subtype cluster, but some moved to another subtype and accordingly had different outcomes. PMID:27611911

  8. Timing of the maturation transition in haddock Melanogrammus aeglefinus.

    Science.gov (United States)

    Tobin, D; Wright, P J; O'Sullivan, M

    2010-10-01

    The timing of maturation in haddock Melanogrammus aeglefinus was examined using changes in gonad development, follicle stimulating hormone β (FSH-β) transcript expression profile, growth and condition of 1 year old females held under a common environment between the summer and winter solstices. The circumnuclear ring, cortical alveolus and vitellogenic oocyte stages were first observed in August, October and November, respectively. FSH-β transcript levels did not change significantly until September but increased markedly thereafter in maturing fish. A combined analysis of the mean oocyte diameter of the leading cohort, histological staging and FSH-β transcript profile provided evidence of a commitment to maturation by October or November. Contrary to that previously proposed for gadoid species, histological analysis of field-caught immature M. aeglefinus during the spawning season indicated that cortical alveolar, rather than circumnuclear ring, stage oocytes provided definitive evidence of maturation. A decrease in relative liver size following the summer solstice suggested a possible link between energy status and maturation.

  9. Landau level transitions in doped graphene in a time dependent magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ardenghi, J.S., E-mail: jsardenghi@gmail.com; Bechthold, P.; Jasen, P.; Gonzalez, E.; Nagel, O.

    2013-10-15

    The aim of this work is to describe the Landau level transitions of Bloch electrons in doped graphene with an arbitrary time dependent magnetic field in the long wavelength approximation. In particular, transitions from the m Landau level to the m±1 and m±2 Landau levels are studied using the time dependent perturbation theory. Time intervals are computed in which transition probabilities tend to zero at a low order in the coupling constant. In particular, Landau level transitions are studied in the case of Bloch electrons traveling in the direction of the applied magnetic force and the results are compared with classical and revival periods of electrical current in graphene. Finally, current probabilities are computed for the n=0 and n=1 Landau levels showing expected oscillating behavior with modified cyclotron frequency.

  10. Intermittency transition to generalized synchronization in coupled time-delay systems.

    Science.gov (United States)

    Senthilkumar, D V; Lakshmanan, M

    2007-12-01

    We report the nature of the transition to generalized synchronization (GS) in a system of two coupled scalar piecewise linear time-delay systems using the auxiliary system approach. We demonstrate that the transition to GS occurs via an on-off intermittency route and that it also exhibits characteristically distinct behaviors for different coupling configurations. In particular, the intermittency transition occurs in a rather broad range of coupling strength for the error feedback coupling configuration and in a narrow range of coupling strength for the direct feedback coupling configuration. It is also shown that the intermittent dynamics displays periodic bursts of periods equal to the delay time of the response system in the former case, while they occur in random time intervals of finite duration in the latter case. The robustness of these transitions with system parameters and delay times has also been studied for both linear and nonlinear coupling configurations. The results are corroborated analytically by suitable stability conditions for asymptotically stable synchronized states and numerically by the probability of synchronization and by the transition of sub-Lyapunov exponents of the coupled time-delay systems. We have also indicated the reason behind these distinct transitions by referring to the unstable periodic orbit theory of intermittency synchronization in low-dimensional systems.

  11. Exploring business process modelling paradigms and design-time to run-time transitions

    Science.gov (United States)

    Caron, Filip; Vanthienen, Jan

    2016-09-01

    The business process management literature describes a multitude of approaches (e.g. imperative, declarative or event-driven) that each result in a different mix of process flexibility, compliance, effectiveness and efficiency. Although the use of a single approach over the process lifecycle is often assumed, transitions between approaches at different phases in the process lifecycle may also be considered. This article explores several business process strategies by analysing the approaches at different phases in the process lifecycle as well as the various transitions.

  12. In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems

    Directory of Open Access Journals (Sweden)

    Maiwald Thomas

    2012-02-01

    Full Text Available Abstract Background Mathematical models of dynamical systems facilitate the computation of characteristic properties that are not accessible experimentally. In cell biology, two main properties of interest are (1 the time-period a protein is accessible to other molecules in a certain state - its half-life - and (2 the time it spends when passing through a subsystem - its transit-time. We discuss two approaches to quantify the half-life, present the novel method of in silico labeling, and introduce the label half-life and label transit-time. The developed method has been motivated by laboratory tracer experiments. To investigate the kinetic properties and behavior of a substance of interest, we computationally label this species in order to track it throughout its life cycle. The corresponding mathematical model is extended by an additional set of reactions for the labeled species, avoiding any double-counting within closed circuits, correcting for the influences of upstream fluxes, and taking into account combinatorial multiplicity for complexes or reactions with several reactants or products. A profile likelihood approach is used to estimate confidence intervals on the label half-life and transit-time. Results Application to the JAK-STAT signaling pathway in Epo-stimulated BaF3-EpoR cells enabled the calculation of the time-dependent label half-life and transit-time of STAT species. The results were robust against parameter uncertainties. Conclusions Our approach renders possible the estimation of species and label half-lives and transit-times. It is applicable to large non-linear systems and an implementation is provided within the PottersWheel modeling framework (http://www.potterswheel.de.

  13. Transit times and age distributions for reservoir models represented as nonlinear non-autonomuous systems

    Science.gov (United States)

    Müller, Markus; Meztler, Holger; Glatt, Anna; Sierra, Carlos

    2016-04-01

    We present theoretical methods to compute dynamic residence and transit time distributions for non-autonomous systems of pools governed by coupled nonlinear differential equations. Although transit time and age distributions have been used to describe reservoir models for a long time, a closer look to their assumptions reveals two major restrictions of generality in previous studies. First, the systems are assumed to be in equilibrium; and second, the equations under consideration are assumed to be linear. While both these assumptions greatly ease the computation and interpretation of transit time and age distributions they are not applicable to a wide range of problems. Moreover, the transfer of previous results learned from linear systems in steady state to the more complex nonlinear non-autonomous systems that do not even need to have equilibria, can be dangerously misleading. Fortunately the topic of time dependent age and transit time distributions has received some attention recently in hydrology, we aim to compute these distributions for systems of multiple reservoirs. We will discuss how storage selection functions can augment the information represented in an ODE system describing a system of reservoirs. We will present analytical and numerical algorithms and a Monte Carlo simulator to compute solutions for system transit time and age distributions for system-wide storage selection functions including the most simple, but important case of well mixed pools.

  14. Attenuation of systolic blood pressure and pulse transit time hysteresis during exercise and recovery in cardiovascular patients.

    Science.gov (United States)

    Liu, Qing; Yan, Bryan P; Yu, Cheuk-Man; Zhang, Yuan-Ting; Poon, Carmen C Y

    2014-02-01

    Pulse transit time (PTT) is a cardiovascular parameter of emerging interest due to its potential to estimate blood pressure (BP) continuously and without a cuff. Both linear and nonlinear equations have been used in the estimation of BP based on PTT. This study, however, demonstrates that there is a hysteresis phenomenon between BP and PTT during and after dynamic exercise. A total of 46 subjects including 16 healthy subjects, 13 subjects with one or more cardiovascular risk factors, and 17 patients with cardiovascular disease underwent graded exercise stress test. PTT was measured from electrocardiogram and photoplethysmogram of the left index finger of the subject, i.e., a pathway that includes predominately aorta, brachial, and radial arteries. The results of this study showed that, for the same systolic BP (SBP), PTT measured during exercise was significantly larger than PTT measured during recovery for all subject groups. This hysteresis was further quantified as both normalized area bounded by the SBP-PTT relationship (AreaN) and SBP difference at PTT during peak exercise plus 20 ms (ΔSBP20). Significant attenuation of both AreaN (p <; 0.05) and ΔSBP20 (p <; 0.01) is observed in cardiovascular patients compared with healthy subjects, independent of resting BP. Since the SBP-PTT relationship are determined by the mechanical properties of arterial wall, which is predominately mediated by the sympathetic nervous system through altered vascular smooth muscle (VSM) tone during exercise, results of this study are consistent with the previous findings of autonomic nervous dysfunction in cardiovascular patients. We further conclude that VSM tone has a nonnegligible influence on the BP-PTT relationship and thus should be considered in the PTT-based BP estimation. PMID:24158470

  15. Transition to parenthood and mental health in first-time parents

    OpenAIRE

    Parfitt, Y.; Ayers, S.

    2014-01-01

    This study aimed to examine the transition to parenthood and mental health in first-time parents in detail and explore any differences in this transition in the context of parental gender and postpartum mental health. Semistructured clinical interviews (Birmingham Interview for Maternal Mental Health) were carried out with 46 women and 40 men, 5 months after birth. Parents were assessed on pre- and postpartum anxiety, depression, and postpartum posttraumatic stress disorder (PTSD), and a rang...

  16. State Estimation for Nonlinear Discrete-Time Systems with Markov Jumps and Nonhomogeneous Transition Probabilities

    OpenAIRE

    Shunyi Zhao; Zhiguo Wang; Fei Liu

    2013-01-01

    State estimation problem is addressed for a class of nonlinear discrete-time systems with Markov parameters and nonhomogeneous transition probabilities (TPs). In this paper, the optimal estimation mechanism of transition probability matrix is proposed in the minimum mean square error sense to show some critical points. Based on this mechanism, the extended Kalman filters are employed as the subfilters to obtain the subestimates with corresponding models. A novel operator which fuses the prior...

  17. Can The Markov Switching Model with Time Varying Transition Probabilities Forecast Exchange Rates?

    OpenAIRE

    Bong-Han Kim; Joong-Haeng Lee

    2001-01-01

    We use Lee's (1991) Markov switching model with time varying transition probabilities (the TVTP Markov model) to analyze the behavior of the U.S. dollar/ British Pound exchange rate. We employ the magnitude of the deviation of the exchange rate from a monetary equilibrium value as the economic fundamental with which the transition probabilities vary. The empirical results we obtained from this paper are the following: first, the deviation of the exchange rate from a monetary equilibrium value...

  18. Calibration of pulse transit time through a cable for EAS experiments

    CERN Document Server

    Xiang-Li, Qian; Cun-Feng, Feng; Zhao-Yang, Feng; Quan-Bu, Gou; Yi-Qing, Guo; Hong-Bo, Hu; Cheng, Liu; Zheng, Wang; Liang, Xue; Xue-Yao, Zhang; Yi, Zhang

    2013-01-01

    In ground-based extensive air shower experiments, the direction and energy are reconstructed by measuring the relative arrival time of secondary particles, and the energy they deposit. The measurement precision of the arrival time is crucial for determination of the angular resolution. For this purpose, we need to obtain a precise relative time offset for each detector, and to apply the calibration process. The time offset is associated with the photomultiplier tube, cable, relevant electronic circuits, etc. In view of the transit time through long cables being heavily dependent on the ambient temperature, a real-time calibration method for the cable transit time is investigated in this paper. Even with a poor-resolution time-to-digital converter, this method can achieve high precision. This has been successfully demonstrated with the Front-End-Electronic board used in the Daya Bay neutrino experiment.

  19. Transit Timing Observations from Kepler. IX. Catalog of the Full Long-Cadence Data Set

    OpenAIRE

    Holczer, Tomer; Mazeh, Tsevi; Nachmani, Gil; Jontof-Hutter, Daniel; Ford, Eric B.; Fabrycky, Daniel; Ragozzine, Darin; Kane, Mackenzie; Steffen, Jason H.

    2016-01-01

    We present a new transit timing catalog of 2599 Kepler Objects of Interest (=KOIs), using the PDC-MAP long-cadence light curves that include the full seventeen quarters of the mission (ftp://wise- ftp.tau.ac.il/pub/tauttv/TTV/ver_112). The goal is to produce an easy-to-use catalog that can stimulate further analyses of interesting systems. For 779 KOIs with high enough SNRs, we derived the timing, duration and depth of 69,914 transits. For 1820 KOIs with lower SNR, we derived only the timing ...

  20. Transition to complete synchronization and global intermittent synchronization in an array of time-delay systems

    Science.gov (United States)

    Suresh, R.; Senthilkumar, D. V.; Lakshmanan, M.; Kurths, J.

    2012-07-01

    We report the nature of transitions from the nonsynchronous to a complete synchronization (CS) state in arrays of time-delay systems, where the systems are coupled with instantaneous diffusive coupling. We demonstrate that the transition to CS occurs distinctly for different coupling configurations. In particular, for unidirectional coupling, locally (microscopically) synchronization transition occurs in a very narrow range of coupling strength but for a global one (macroscopically) it occurs sequentially in a broad range of coupling strength preceded by an intermittent synchronization. On the other hand, in the case of mutual coupling, a very large value of coupling strength is required for local synchronization and, consequently, all the local subsystems synchronize immediately for the same value of the coupling strength and, hence, globally, synchronization also occurs in a narrow range of the coupling strength. In the transition regime, we observe a type of synchronization transition where long intervals of high-quality synchronization which are interrupted at irregular times by intermittent chaotic bursts simultaneously in all the systems and which we designate as global intermittent synchronization. We also relate our synchronization transition results to the above specific types using unstable periodic orbit theory. The above studies are carried out in a well-known piecewise linear time-delay system.

  1. The determination of allowed outage time using the evaluation of transition risk

    International Nuclear Information System (INIS)

    he objectives of this study are to propose a new evaluation method for transition risk and to determine the AOT using the new method. We review and compare the evaluation methods of transition risk which was previously studied. We also identify important assumptions used in previous studies for the evaluation of transition risk. We select general items required for the development of evaluation method for the transition risk. Based on the items selected, we propose a new evaluation method for transition risk. The new evaluation method for the transition risk is based on following assumptions; 1)For the same time span, the risk occurred from the failure to the completion of component repair during power operation is the same as the total risk including the risk occurred from power operation to specific shutdown/low power operation and the risk from specific shutdown/low power operation to power operation. 2)Shutdown operation and the repair of components are initiated just after the identification of the failure of components. The evaluation of the transition risk is performed to incorporate the characteristics of shutdown operation into Ulchin Units 3 and 4 Level 1 internal PSA for power operation. The application results of the new method to the HPSIS and the LPSIS for Ulchin Units 3 and 4 show that the AOT of HPSIS is properly determined and the AOT of LPSIS can be greatly increased. In this study, the main factors affecting the determination of AOT using the evaluation for transition risk are identified as the time of shutdown operation, the consideration of the change on common cause failure probability, and the risk of shutdown operation. It is expected that the evaluation method for the transition risk proposed in this study will be used for the determination of AOT and for the decision, in the case of the components unavailable, whether power operation is continuously performed or shutdown operation is initiated

  2. Association of Lumbar Arterial Stenosis with Low Back Symptoms: A Cross-Sectional Study Using Two-Dimensional Time-of-Flight Magnetic Resonance Angiography

    International Nuclear Information System (INIS)

    Background: Recent studies indicate that diminished blood flow may cause low back symptoms and intervertebral disc degeneration. Purpose: To explore the association between lumbar arterial stenosis as detected by two-dimensional time-of-flight magnetic resonance angiography (2D TOF-MRA) and lumbar pain symptoms in an occupational cohort of middle-aged Finnish males. Material and Methods: 228 male subjects aged 36 to 55 years (mean 47 years) were imaged with 2D TOF-MRA. Additionally, 20 randomly selected subjects were scanned with contrast-enhanced MRA (ceMRA). In each subject, the first (L1) to fourth (L4) segmental lumbar arteries were evaluated for lumbar artery stenosis using a dichotomic scale. One subject was excluded because of poor image quality, reducing the study population to 227 subjects. Logistic regression analysis was used to evaluate the association between arterial stenosis in 2D TOF-MRA and low back pain and sciatica symptoms (intensity, duration, frequency). Results: Comparing 2D TOF-MRA and ceMRA images, the kappa value (95% confidence interval) was 0.52 (0.31-0.73). The intraobserver reliability kappa value for 2D TOF-MRA was 0.85 (0.77-0.92), and interobserver kappa was 0.57 (0.49-0.65). The sensitivity of 2D TOF-MRA in detecting stenosis was 0.58, the accuracy 0.89, and the specificity 0.94. In 97 (43%) subjects all arteries were normal, whereas 130 (57%) had at least one stenosed artery. The left L4 artery was most often affected. The degree of arterial stenosis was associated with intensity of low back and sciatic pain, and sciatica pain duration during the past 3 months. Conclusion: 2D TOF-MRA is an acceptable imaging method for arterial stenosis compared to ceMRA. Arterial stenosis was associated with subjective pain symptoms, indicating a role of decreased nutrition in spinal disorders

  3. Association of Lumbar Arterial Stenosis with Low Back Symptoms: A Cross-Sectional Study Using Two-Dimensional Time-of-Flight Magnetic Resonance Angiography

    Energy Technology Data Exchange (ETDEWEB)

    Korkiakoski, A.; Niinimaeki, J.; Karppinen, J.; Korpelainen, R.; Haapea, M.; Natri, A.; Tervonen, O. (Inst. of Clinical Sciences, Dept. of Physical and Rehabilitation Medicine, Univ. of Oulu, Oulu (Finland))

    2009-01-15

    Background: Recent studies indicate that diminished blood flow may cause low back symptoms and intervertebral disc degeneration. Purpose: To explore the association between lumbar arterial stenosis as detected by two-dimensional time-of-flight magnetic resonance angiography (2D TOF-MRA) and lumbar pain symptoms in an occupational cohort of middle-aged Finnish males. Material and Methods: 228 male subjects aged 36 to 55 years (mean 47 years) were imaged with 2D TOF-MRA. Additionally, 20 randomly selected subjects were scanned with contrast-enhanced MRA (ceMRA). In each subject, the first (L1) to fourth (L4) segmental lumbar arteries were evaluated for lumbar artery stenosis using a dichotomic scale. One subject was excluded because of poor image quality, reducing the study population to 227 subjects. Logistic regression analysis was used to evaluate the association between arterial stenosis in 2D TOF-MRA and low back pain and sciatica symptoms (intensity, duration, frequency). Results: Comparing 2D TOF-MRA and ceMRA images, the kappa value (95% confidence interval) was 0.52 (0.31-0.73). The intraobserver reliability kappa value for 2D TOF-MRA was 0.85 (0.77-0.92), and interobserver kappa was 0.57 (0.49-0.65). The sensitivity of 2D TOF-MRA in detecting stenosis was 0.58, the accuracy 0.89, and the specificity 0.94. In 97 (43%) subjects all arteries were normal, whereas 130 (57%) had at least one stenosed artery. The left L4 artery was most often affected. The degree of arterial stenosis was associated with intensity of low back and sciatic pain, and sciatica pain duration during the past 3 months. Conclusion: 2D TOF-MRA is an acceptable imaging method for arterial stenosis compared to ceMRA. Arterial stenosis was associated with subjective pain symptoms, indicating a role of decreased nutrition in spinal disorders

  4. Timing Preferences for Women's Family-Life Transitions: Intergenerational Transmission among Migrants and Dutch

    Science.gov (United States)

    de Valk, Helga A. G.; Liefbroer, Aart C.

    2007-01-01

    This study examines the transmission of preferences regarding the timing of family-life transitions of women among migrant and native Dutch families. We study how and to what extent parental preferences, migrant origin, and family characteristics affect the child's timing preferences. We use parent and child data (N = 1,290) from the Netherlands…

  5. Timing preferences for women's family life transitions: intergenerational transmission among migrants and Dutch

    NARCIS (Netherlands)

    de Valk, H.A.G.; Liefbroer, A.C.

    2007-01-01

    This study examines the transmission of preferences regarding the timing of family-life transitions of women among migrant and native Dutch families. We study how and to what extent parental preferences, migrant origin, and family characteristics affect the child’s timing preferences. We use parent

  6. Selective arterial embolization for control of haematuria secondary to advanced or recurrent transitional cell carcinoma of the bladder.

    LENUS (Irish Health Repository)

    Halpenny, D

    2014-05-02

    Haematuria is a common symptom in patients with advanced transitional cell carcinoma of the bladder. We report our experience of selective pelvic embolization using gelfoam as an embolic agent to treat intractable haematuria in these patients.

  7. Pulse-echo ultrasound transit time spectroscopy: A comparison of experimental measurement and simulation prediction.

    Science.gov (United States)

    Wille, Marie-Luise; Almualimi, Majdi A; Langton, Christian M

    2016-01-01

    Considering ultrasound propagation through complex composite media as an array of parallel sonic rays, a comparison of computer-simulated prediction with experimental data has previously been reported for transmission mode (where one transducer serves as transmitter, the other as receiver) in a series of 10 acrylic step-wedge samples, immersed in water, exhibiting varying degrees of transit time inhomogeneity. In this study, the same samples were used but in pulse-echo mode, where the same ultrasound transducer served as both transmitter and receiver, detecting both 'primary' (internal sample interface) and 'secondary' (external sample interface) echoes. A transit time spectrum was derived, describing the proportion of sonic rays with a particular transit time. A computer simulation was performed to predict the transit time and amplitude of various echoes created, and compared with experimental data. Applying an amplitude-tolerance analysis, 91.7% ± 3.7% of the simulated data were within ±1 standard deviation of the experimentally measured amplitude-time data. Correlation of predicted and experimental transit time spectra provided coefficients of determination (R(2)%) ranging from 100.0% to 96.8% for the various samples tested. The results acquired from this study provide good evidence for the concept of parallel sonic rays. Furthermore, deconvolution of experimental input and output signals has been shown to provide an effective method to identify echoes otherwise lost due to phase cancellation. Potential applications of pulse-echo ultrasound transit time spectroscopy include improvement of ultrasound image fidelity by improving spatial resolution and reducing phase interference artefacts. PMID:26586528

  8. Pulse-echo ultrasound transit time spectroscopy: A comparison of experimental measurement and simulation prediction.

    Science.gov (United States)

    Wille, Marie-Luise; Almualimi, Majdi A; Langton, Christian M

    2016-01-01

    Considering ultrasound propagation through complex composite media as an array of parallel sonic rays, a comparison of computer-simulated prediction with experimental data has previously been reported for transmission mode (where one transducer serves as transmitter, the other as receiver) in a series of 10 acrylic step-wedge samples, immersed in water, exhibiting varying degrees of transit time inhomogeneity. In this study, the same samples were used but in pulse-echo mode, where the same ultrasound transducer served as both transmitter and receiver, detecting both 'primary' (internal sample interface) and 'secondary' (external sample interface) echoes. A transit time spectrum was derived, describing the proportion of sonic rays with a particular transit time. A computer simulation was performed to predict the transit time and amplitude of various echoes created, and compared with experimental data. Applying an amplitude-tolerance analysis, 91.7% ± 3.7% of the simulated data were within ±1 standard deviation of the experimentally measured amplitude-time data. Correlation of predicted and experimental transit time spectra provided coefficients of determination (R(2)%) ranging from 100.0% to 96.8% for the various samples tested. The results acquired from this study provide good evidence for the concept of parallel sonic rays. Furthermore, deconvolution of experimental input and output signals has been shown to provide an effective method to identify echoes otherwise lost due to phase cancellation. Potential applications of pulse-echo ultrasound transit time spectroscopy include improvement of ultrasound image fidelity by improving spatial resolution and reducing phase interference artefacts.

  9. Transit time of a freely-falling quantum particle in a background gravitational field

    CERN Document Server

    Davies, Paul Charles William

    2004-01-01

    Using a model quantum clock, I evaluate an expression for the time of a non-relativistic quantum particle to transit a piecewise geodesic path in a background gravitational field with small spacetime curvature (gravity gradient), in the case that the apparatus is in free fall. This calculation complements and extends an earlier one (Davies 2004) in which the apparatus is fixed to the surface of the Earth. The result confirms that, for particle velocities not too low, the quantum and classical transit times coincide, in conformity with the principle of equivalence. I also calculate the quantum corrections to the transit time when the de Broglie wavelengths are long enough to probe the spacetime curvature. The results are compared with the calculation of Chaio and Speliotopoulos (2003), who propose an experiment to measure the foregoing effects.

  10. Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans.

    Science.gov (United States)

    Bouchoucha, M; Salles, J P; Fallet, M; Frileux, P; Cugnenc, P H; Barbier, J P

    1992-01-01

    Pinaverium bromide is a specific calcium channel blocker used in the treatment of irritable bowel syndrome (IBS) for its spasmolytic activity. The aim of the present study was to evaluate the effect of orally administered pinaverium bromide on jejunal motility and total and segmental colonic transit time in control subjects. Gastrointestinal studies were performed in 10 healthy volunteers (30 +/- 3 years), before and after a treatment phase of 14 days (150 mg/d). Jejunal motility was measured by prolonged manometry (14 h) and colonic transit time by a multiple ingestion, single marker technique. No significant modification of phase III of the migrating motor complexes was demonstrated. On the contrary, a significant (p < 0.01) but weak decrease of the frequency of contraction was found. Unlike previous studies, no decrease of total or segmental colonic transit time was demonstrated. PMID:1421047

  11. Transit time of a freely falling quantum particle in a background gravitational field

    International Nuclear Information System (INIS)

    Using a model quantum clock, I evaluate an expression for the time of a non-relativistic quantum particle to transit a piecewise geodesic path in a background gravitational field with small spacetime curvature (gravity gradient), in the case in which the apparatus is in free fall. This calculation complements and extends an earlier one (Davies 2004) in which the apparatus is fixed to the surface of the Earth. The result confirms that, for particle velocities not too low, the quantum and classical transit times coincide, in conformity with the principle of equivalence. I also calculate the quantum corrections to the transit time when the de Broglie wavelengths are long enough to probe the spacetime curvature. The results are compared with the calculation of Chiao and Speliotopoulos (2003), who propose an experiment to measure the foregoing effects

  12. Effect of Equal and Mismatched Signal Transition Time on Power Dissipation in Global VLSI Interconnects

    Directory of Open Access Journals (Sweden)

    Devendra Kumar Sharma

    2012-09-01

    Full Text Available High density chips have introduced problems like crosstalk noise and power dissipation. The mismatching in transition time of the inputs occurs because different lengths of interconnects lead to different parasitic values. This paper presents the analysis of the effect of equal and unequal (mismatched transition time of inputs on power dissipation in coupled interconnects. Further, the effect of signal skew on transition time is analysed. To demonstrate the effects, a model of two distributed RLC lines coupled capacitively and inductively is taken into consideration. Each interconnect line is 4mm long and terminated by capacitive load of 30fF. The analysis is carried out for simultaneously switching lines. The results are obtained through SPICE simulations and waveforms are generated.

  13. Scintigraphic small intestinal transit time and defaecography in patients with J-pouch

    DEFF Research Database (Denmark)

    Kjær, Mie Dilling; Simonsen, Jane Angel; Hvidsten, Svend;

    2015-01-01

    Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. The objective of this study was to evaluate the results of scintigraphic intestinal transit time and defaecography compared to the results of pouch...... mucosal condition was evaluated by endoscopy and histology. Median transit time was 189 min (105–365). Median ejection fraction at defaecography (EF) was 49% (3–77) and 62% (17–98) after first and second defecation. Median pouch volume was 223 mL (100–360). A median daily stool frequency of nine (4......–25) was reported and three (14%) patients suffered from daytime incontinence. No patients had symptomatic or endoscopic pouchitis; however, the histology showed unspecific inflammation in 19 (90%) patients. There was no correlation between transit time, evacuation fraction (EF) and pouch function in univariate...

  14. Real-time myocardial contrast echocardiography and its applications in evaluation for coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    杨莉

    2004-01-01

    It is important to assess myocardial perfusion in the diagnosis, treatment and risk stratification of patients with coronary artery disease. At present, single-photon emission computed tomography (SPECT) is used to evaluate myocardial perfusion, but it is limited by relatively low spatial resolution, the need to inject radioisotopes, and not being able to be performed at the patient ' s bedside. Using intracoronary injection of ultrasound contrast agent, the potential of myocardial contrast echocardiography (MCE) instead of perfusion assessment has been proved in numerous animal and human studies. Recent improvements in contrast agents have resulted in stable microbubbles that, following intravenous administration, traverse the pulmonary circulation and reach the left heart. Combined with the emergence of contrast-specific imaging modalities along with quantitative analytical method, intravenous MCE is now a feasible and promising noninvasive technique for perfusion assessment.

  15. Dynamic detection of wake-sleep transition with reaction time-magnitude

    Institute of Scientific and Technical Information of China (English)

    Chuang Gao; Bin Chen; Wei Wei

    2009-01-01

    BACKGROUND: According to observable behaviors, sleep and wakefulness are two fundamentally different behavioral states. Although electroencephalogram (EEG) is traditionally used to define sleep stage, it is difficult to detect or to quantify microarousals or disruptions during sleep. In addition,initial sleep cannot be defined. It is thought that the wake-sleep transition cannot be defined by EEG patterns.OBJECTIVE: To observe the behavioral response magnitude during wake-sleep transition by EEG monitoring and to define the wake-sleep transition.DESIGN, TIME AND SE'n'ING: A behavioral and neural network study was performed at the Key Lab of Human Being Development and Mental Health of Central China Normal University, and Lab of Brain and Cognitive Science of South Central University for Nationalities, China in July 2007.PARTICIPANTS: A total of 30 healthy volunteers, of equal gender and aged (19.7+1.1) years, were recruited from the Central China Normal University, China for this study. None of the subjects had undergone EEG recording prior to this study or received any medication for sleep disturbances.METHODS: A novel adaptive approach was applied to detect wake-sleep transition, which avoided stimulus-induced waking. To test the difference between wake state and wake-sleep transition, the amount of self-information and mutual-information were effective parameters to analyze wake-sleep transition.MAIN OUTCOME MEASURES: The following parameters were measured: morphological changes in reaction time-magnitude, as well as correlation between phase changes and sleep, and wake and wake-sleep transition.RESULTS: There were three typical phases in morphological changes of reaction time-magnitude.With regard to the behavioral definition and criterion for sleep, the phase morphological characteristics displayed good correlation with behavioral states, such as sleep, wakefulness, and sleep onset. Entropy as an indicator of brain cognitive processes was introduced to test

  16. Estimation of the transition matrix of a discrete-time Markov chain.

    Science.gov (United States)

    Craig, Bruce A; Sendi, Peter P

    2002-01-01

    Discrete-time Markov chains have been successfully used to investigate treatment programs and health care protocols for chronic diseases. In these situations, the transition matrix, which describes the natural progression of the disease, is often estimated from a cohort observed at common intervals. Estimation of the matrix, however, is often complicated by the complex relationship among transition probabilities. This paper summarizes methods to obtain the maximum likelihood estimate of the transition matrix when the cycle length of the model coincides with the observation interval, the cycle length does not coincide with the observation interval, and when the observation intervals are unequal in length. In addition, the bootstrap is discussed as a method to assess the uncertainty of the maximum likelihood estimate and to construct confidence intervals for functions of the transition matrix such as expected survival. PMID:11788980

  17. Nonlinear light behaviors near phase transition in non-parity-time-symmetric complex waveguides

    CERN Document Server

    Nixon, Sean

    2016-01-01

    Many classes of non-parity-time (PT) symmetric waveguides with arbitrary gain and loss distributions still possess all-real linear spectrum or exhibit phase transition. In this article, nonlinear light behaviors in these complex waveguides are probed analytically near a phase transition. Using multi-scale perturbation methods, a nonlinear ordinary differential equation (ODE) is derived for the light's amplitude evolution. This ODE predicts that the first class of these non-PT-symmetric waveguides support continuous families of solitons and robust amplitude-oscillating solutions both above and below phase transition, in close analogy with PT-symmetric systems. For the other classes of waveguides, the light's intensity always amplifies under the effect of nonlinearity even if the waveguide is below phase transition. These analytical predictions are confirmed by direct computations of the full system.

  18. Nonlinear light behaviors near phase transition in non-parity-time-symmetric complex waveguides.

    Science.gov (United States)

    Nixon, Sean; Yang, Jianke

    2016-06-15

    Many classes of non-parity-time (PT)-symmetric waveguides with arbitrary gain and loss distributions still possess all-real linear spectrum or exhibit phase transition. In this Letter, nonlinear light behaviors in these complex waveguides are probed analytically near a phase transition. Using multi-scale perturbation methods, a nonlinear ordinary differential equation (ODE) is derived for the light's amplitude evolution. This ODE predicts that a single class of these non-PT-symmetric waveguides supports soliton families and amplitude-oscillating solutions both above and below linear phase transition, in close analogy with PT-symmetric systems. For the other classes of waveguides, the light's intensity always amplifies under the effect of nonlinearity, even if the waveguide is below the linear phase transition. These analytical predictions are confirmed by direct computations of the full system. PMID:27304279

  19. Mean transit times in contrasting headwater catchments from southeast Australia determined using Tritium

    Science.gov (United States)

    Cartwright, Ian; Morgenstern, Uwe; Irvine, Dylan

    2016-04-01

    Headwater streams contribute a significant proportion of the total discharge of many river systems. However, despite their importance, the time taken for rainfall to pass through the catchment into the streams (the transit time) in headwater catchments is largely unknown as are the catchment characteristics (such as drainage density, topography, landuse, or geology) that determine variations in transit times. Because the peak in Tritium activities in rainfall produced by atmospheric nuclear tests in the1950's and 1960's (the "bomb-pulse") was several orders of magnitude lower in the southern hemisphere than in the northern hemisphere, Tritium activities of remnant bomb pulse water in the southern hemisphere have decayed below those of modern rainfall. This allows mean transit times to be estimated from single Tritium measurements. Here we use Tritium to estimate transit times of water contributing to perennial streams in the adjacent upper catchments of the Yarra and Latrobe Rivers (southeast Australia). Samples were collected at varying flow from six headwater tributary sites in the Latrobe catchment, which is largely forested and four tributaries in the Yarra catchment which has been extensively cleared for dryland agriculture. The lowest Tritium activities were recorded during summer baseflow conditions and are between 1.25 and 1.75 TU, these are significantly below the Tritium activity of local rainfall (~2.8 TU). Mean transit times calculated using an exponential-piston flow lumped parameter model are 21 to 47 years. Tritium activities during the recession periods following winter high flows are higher (1.54 to 2.1 TU), which may reflect either the dilution of a baseflow component with recent surface runoff or mobilisation of different stores of water with different residence times (e.g., from the soils or the regolith) from within the catchment. The variation of major ion concentrations with discharge suggests it is more likely that that different stores of

  20. Optical and x-ray time resolved study of the structural transition in mixed valence manganites

    Directory of Open Access Journals (Sweden)

    Jia Q. X.

    2013-03-01

    Full Text Available Time resolved optical reflectivity and x-ray diffraction techniques are employed to study the laser-induced structural response in two charge and orbitally ordered manganites. Optical data indicate a non-thermal nature of the laser-triggered phase transition via the disappearance of an optical phonon related to the charge and orbitally ordered phase. The x-ray diffraction measurements on superlattice reflections confirm the non-thermal time scale of the initial step of this phase transition but also show that the complete change of structural symmetry is not instantaneous.

  1. Nonparametric estimation in an "illness-death" model when all transition times are interval censored

    DEFF Research Database (Denmark)

    Frydman, Halina; Gerds, Thomas; Grøn, Randi;

    2013-01-01

    being interval censored, the times of two events (0 → 1 and 1 → 2 transitions) can be censored into the same interval. This development was motivated by a common data structure in oral health research, here specifically illustrated by the data from a prospective cohort study on the longevity of dental...... veneers. Using the self-consistency algorithm we obtain the maximum likelihood estimators of the cumulative incidences of the times to events 1 and 2 and of the intensity of the 1 → 2 transition. This work generalizes previous results on the estimation in an "illness-death" model from interval censored...

  2. Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH)

    DEFF Research Database (Denmark)

    Gutiérrez-Jiménez, Eugenio; Cai, Changsi; Mikkelsen, Irene Klærke;

    2016-01-01

    microvascular networks. Electrical forepaw stimulation reduced, both mean transit time (11.3% ± 1.3%) and capillary transit-time heterogeneity (24.1% ± 3.3%), consistent with earlier literature and model predictions. We observed a coefficient of variance reduction (14.3% ± 3.5%) during functional activation......, especially for the arteriolar-to-venular passage. Such coefficient of variance reduction during functional activation suggests homogenization of capillary flows beyond that expected as a passive response to increased blood flow by other stimuli. This finding is consistent with an active neurocapillary...

  3. Robust Finite-Time H∞ Control for Nonlinear Markovian Jump Systems with Time Delay under Partially Known Transition Probabilities

    Directory of Open Access Journals (Sweden)

    Dong Yang

    2014-01-01

    Full Text Available This paper is concerned with the problem of robust finite-time H∞ control for a class of nonlinear Markovian jump systems with time delay under partially known transition probabilities. Firstly, for the nominal nonlinear Markovian jump systems, sufficient conditions are proposed to ensure finite-time boundedness, H∞ finite-time boundedness, and finite-time H∞ state feedback stabilization, respectively. Then, a robust finite-time H∞ state feedback controller is designed, which, for all admissible uncertainties, guarantees the H∞ finite-time boundedness of the corresponding closed-loop system. All the conditions are presented in terms of strict linear matrix inequalities. Finally a numerical example is provided to demonstrate the effectiveness of all the results.

  4. Time-dependent Mott transition in the periodic Anderson model with nonlocal hybridization

    Science.gov (United States)

    Hofmann, Felix; Potthoff, Michael

    2016-08-01

    The time-dependent Mott transition in a periodic Anderson model with off-site, nearest-neighbor hybridization is studied within the framework of nonequilibrium self-energy functional theory. Using the two-site dynamical-impurity approximation, we compute the real-time dynamics of the optimal variational parameter and of different observables initiated by sudden quenches of the Hubbard-U and identify the critical interaction. The time-dependent transition is orbital selective, i.e., in the final state, reached in the long-time limit after the quench to the critical interaction, the Mott gap opens in the spectral function of the localized orbitals only. We discuss the dependence of the critical interaction and of the final-state effective temperature on the hybridization strength and point out the various similarities between the nonequilibrium and the equilibrium Mott transition. It is shown that these can also be smoothly connected to each other by increasing the duration of a U-ramp from a sudden quench to a quasi-static process. The physics found for the model with off-site hybridization is compared with the dynamical Mott transition in the single-orbital Hubbard model and with the dynamical crossover found for the real-time dynamics of the conventional Anderson lattice with on-site hybridization.

  5. Time-resolved small-angle neutron scattering of a micelle-to-vesicle transition

    Energy Technology Data Exchange (ETDEWEB)

    Egelhaaf, S.U. [Institut Max von Laue - Paul Langevin (ILL), 38 -Grenoble (France); Schurtenberger, P. [Eidgenoessische Technische Hochschule, Zurich (Switzerland)

    1997-04-01

    Amphiphilic molecules spontaneously self-assemble in solution to form a variety of aggregates. Only limited information is available on the kinetics of the structural transitions as well as on the existence of non-equilibrium or metastable states. Aqueous mixtures of lecithin and bile salt are very interesting biological model-systems which exhibit a spontaneous transition from polymer-like mixed micelles to vesicles upon dilution. The small-angle neutron scattering (SANS) instrument D22, with its very high neutron flux and the broad range of scattering vectors covered in a single instrumental setting, allowed us for the first time to perform time-resolved scattering experiments in order to study the micelle-to-vesicle transition. The temporal evolution of the aggregate structures were followed and detailed information was obtained even on molecular length-scales. (author). 5 refs.

  6. Real-time ultrasound perfusion imaging in acute stroke: assessment of cerebral perfusion deficits related to arterial recanalization.

    Science.gov (United States)

    Bolognese, Manuel; Artemis, Dimitrios; Alonso, Angelika; Hennerici, Michael G; Meairs, Stephan; Kern, Rolf

    2013-05-01

    We investigated whether real-time ultrasound perfusion imaging (rt-UPI) is able to detect perfusion changes related to arterial recanalization in the acute phase of middle cerebral artery (MCA) stroke. Twenty-four patients with acute territorial MCA stroke were examined with rt-UPI and transcranial color-coded duplex ultrasound (TCCD). Ultrasound studies were consecutively performed within 24 h and 72-96 h after stroke onset. Real-time UPI parameters of bolus kinetics (time to peak, rt-TTP) and of refill kinetics (plateau A and slope β of the exponential replenishment curve) were calculated from regions of interest of ischemic versus normal brain tissue; these parameters were compared between early and follow-up examinations in patients who recanalized. At the early examination, there was a delay of rt-TTP in patients with MCA occlusion (rt-TTP [s]: 13.09 ± 3.21 vs. 10.16 ± 2.6; p = 0.01) and a lower value of the refill parameter β (β [1/s]: 0.62 ± 0.34 vs. 1.09 ± 0.58; p = 0.01) in ischemic compared with normal brain tissue, whereas there were no differences of the parameters A and Axβ. At follow-up, the delay of rt-TTP was reversible once recanalization of an underlying MCA obstruction was demonstrated: rt-TTP [s], 13.09 ± 3.21 at 24 h versus 10.95 ± 1.5 at 72-96 h (p = 0.03). Correspondingly, β showed a higher slope than at the first examination: β [1/s]: 0.55 ± 0.29 at 24 h versus 0.71 ± 0.27 at 72-96 h (p = 0.04). We conclude that real-time UPI can detect hemodynamic impairment in acute MCA occlusion and subsequent improvement following arterial recanalization. This offers the chance for bedside monitoring of the hemodynamic compromise (e.g. during therapeutic interventions such as systemic thrombolysis).

  7. Effect of spike-timing-dependent plasticity on coherence resonance and synchronization transitions by time delay in adaptive neuronal networks

    Science.gov (United States)

    Xie, Huijuan; Gong, Yubing; Wang, Qi

    2016-06-01

    In this paper, we numerically study how time delay induces multiple coherence resonance (MCR) and synchronization transitions (ST) in adaptive Hodgkin-Huxley neuronal networks with spike-timing dependent plasticity (STDP). It is found that MCR induced by time delay STDP can be either enhanced or suppressed as the adjusting rate Ap of STDP changes, and ST by time delay varies with the increase of Ap, and there is optimal Ap by which the ST becomes strongest. It is also found that there are optimal network randomness and network size by which ST by time delay becomes strongest, and when Ap increases, the optimal network randomness and optimal network size increase and related ST is enhanced. These results show that STDP can either enhance or suppress MCR and optimal STDP can enhance ST induced by time delay in the adaptive neuronal networks. These findings provide a new insight into STDP's role for the information processing and transmission in neural systems.

  8. Aggregation in environmental systems: catchment mean transit times and young water fractions under hydrologic nonstationarity

    Directory of Open Access Journals (Sweden)

    J. W. Kirchner

    2015-03-01

    Full Text Available Methods for estimating mean transit times from chemical or isotopic tracers (such as Cl−, δ18O, or δ2H commonly assume that catchments are stationary (i.e. time-invariant and homogeneous. Real catchments are neither. In a companion paper, I showed that catchment mean transit times estimated from seasonal tracer cycles are highly vulnerable to aggregation error, exhibiting strong bias and large scatter in spatially heterogeneous catchments. I proposed a different measure of transit times, the young water fraction, and showed that it is virtually immune to aggregation error under spatial heterogeneity. Here I extend this analysis by exploring how nonstationarity affects mean transit times and young water fractions estimated from seasonal tracer cycles, using benchmark tests based on a simple two-box model. The model exhibits complex nonstationary behavior, with striking volatility in tracer concentrations, young water fractions, and mean transit times, driven by rapid shifts in the mixing ratios of fluxes from the upper and lower boxes. The transit-time distribution in streamflow becomes increasingly skewed at higher discharges, with marked increases in the young water fraction and decreases in the mean water age, reflecting the increased dominance of the upper box at higher flows. Even this simple two-box model exhibits strong equifinality; hydrograph calibration cannot constrain four of its five parameters. This equifinality problem can be partly resolved by simple parameter transformations. However, transit times are primarily determined by residual storage, which cannot be constrained through hydrograph calibration and must instead be estimated by tracer behavior. Seasonal tracer cycles in the two-box model are very poor predictors of mean transit times, with typical errors of several hundred percent. However, the same tracer cycles predict young water fractions within a few percent, even in model catchments that are both nonstationary and

  9. Aggregation in environmental systems: catchment mean transit times and young water fractions under hydrologic nonstationarity

    Science.gov (United States)

    Kirchner, J. W.

    2015-03-01

    Methods for estimating mean transit times from chemical or isotopic tracers (such as Cl-, δ18O, or δ2H) commonly assume that catchments are stationary (i.e. time-invariant) and homogeneous. Real catchments are neither. In a companion paper, I showed that catchment mean transit times estimated from seasonal tracer cycles are highly vulnerable to aggregation error, exhibiting strong bias and large scatter in spatially heterogeneous catchments. I proposed a different measure of transit times, the young water fraction, and showed that it is virtually immune to aggregation error under spatial heterogeneity. Here I extend this analysis by exploring how nonstationarity affects mean transit times and young water fractions estimated from seasonal tracer cycles, using benchmark tests based on a simple two-box model. The model exhibits complex nonstationary behavior, with striking volatility in tracer concentrations, young water fractions, and mean transit times, driven by rapid shifts in the mixing ratios of fluxes from the upper and lower boxes. The transit-time distribution in streamflow becomes increasingly skewed at higher discharges, with marked increases in the young water fraction and decreases in the mean water age, reflecting the increased dominance of the upper box at higher flows. Even this simple two-box model exhibits strong equifinality; hydrograph calibration cannot constrain four of its five parameters. This equifinality problem can be partly resolved by simple parameter transformations. However, transit times are primarily determined by residual storage, which cannot be constrained through hydrograph calibration and must instead be estimated by tracer behavior. Seasonal tracer cycles in the two-box model are very poor predictors of mean transit times, with typical errors of several hundred percent. However, the same tracer cycles predict young water fractions within a few percent, even in model catchments that are both nonstationary and spatially

  10. Simultaneous Optimization of Container Ship Sailing Speed and Container Routing with Transit Time Restrictions

    DEFF Research Database (Denmark)

    Karsten, Christian Vad; Røpke, Stefan; Pisinger, David

    We introduce a decision support tool for liner shipping companies to optimally determine the sailing speed and needed fleet for a global network. As a novelty we incorporate cargo routing decisions with tight transit time restrictions on each container such that we get a realistic picture...

  11. Transit Timing Observations from Kepler. IX. Catalog of the Full Long-Cadence Data Set

    CERN Document Server

    Holczer, Tomer; Nachmani, Gil; Jontof-Hutter, Daniel; Ford, Eric B; Fabrycky, Daniel; Ragozzine, Darin; Kane, Mackenzie; Steffen, Jason H

    2016-01-01

    We present a new transit timing catalog of 2599 Kepler Objects of Interest (=KOIs), using the PDC-MAP long-cadence light curves that include the full seventeen quarters of the mission (ftp://wise- ftp.tau.ac.il/pub/tauttv/TTV/ver_112). The goal is to produce an easy-to-use catalog that can stimulate further analyses of interesting systems. For 779 KOIs with high enough SNRs, we derived the timing, duration and depth of 69,914 transits. For 1820 KOIs with lower SNR, we derived only the timing of 225,273 transits. After removal of outlier timings, we derived various statistics for each KOI that were used to indicate significant variations. Including systems found by previous works, we have detected 260 KOIs which showed significant TTVs with long-term variations (>100 day), and another fourteen KOIs with periodic modulations shorter than 100 day and small amplitudes. For five of those, the periodicity is probably due to the crossing of rotating stellar spots by the transiting planets.

  12. Emotional instability as an indicator of strictly timed infantile developmental transitions

    NARCIS (Netherlands)

    de Weerth, C.; Van Geert, P. L. C.

    1998-01-01

    There are indications that periods of disorganization/instability/regression accompany developmental transitions in early infancy. The goal of the present study was to validate a pattern of 10 strictly timed periods of emotional instability found through maternal reports by van de Rijt-Plooij & Ploo

  13. Dating Violence, Bullying, and Sexual Harassment: Longitudinal Profiles and Transitions over Time

    Science.gov (United States)

    Miller, Shari; Williams, Jason; Cutbush, Stacey; Gibbs, Deborah; Clinton-Sherrod, Monique; Jones, Sarah

    2013-01-01

    Although there is growing recognition of the problem of dating violence, little is known about how it unfolds among young adolescents who are just beginning to date. This study examined classes (subgroups) and transitions between classes over three time points based on dating violence, bullying, and sexual harassment perpetration and victimization…

  14. The Measurement of Time: Children's Construction of Transitivity, Unit Iteration, and Conservation of Speed.

    Science.gov (United States)

    Long, Kathy; Kamii, Constance

    2001-01-01

    Interviews 120 children in kindergarten and grades 2, 4, and 6 with five Piagetian tasks to determine the grade level at which most have constructed transitive reasoning, unit iteration, and conservation of speed. Indicates that construction of the logic necessary to make sense of the measurement of time is generally not complete before sixth…

  15. A transit-time flow meter for measuring milliliter per minute liquid flow

    DEFF Research Database (Denmark)

    Yang, Canqian; Kymmel, Mogens; Søeberg, Henrik

    1988-01-01

    A transit-time flow meter, using periodic temperature fluctuations as tracers, has been developed for measuring liquid flow as small as 0.1 ml/min in microchannels. By injecting square waves of heat into the liquid flow upstream with a tiny resistance wire heater, periodic temperature fluctuations...

  16. Quantum processes: probability fluxes, transition probabilities in unit time and vacuum vibrations

    International Nuclear Information System (INIS)

    Transition probabilities in unit time and probability fluxes are compared in studying the elementary quantum processes -the decay of a bound state under the action of time-varying and constant electric fields. It is shown that the difference between these quantities may be considerable, and so the use of transition probabilities W instead of probability fluxes Π, in calculating the particle fluxes, may lead to serious errors. The quantity W represents the rate of change with time of the population of the energy levels relating partly to the real states and partly to the virtual ones, and it cannot be directly measured in experiment. The vacuum background is shown to be continuously distorted when a perturbation acts on a system. Because of this the viewpoint of an observer on the physical properties of real particles continuously varies with time. This fact is not taken into consideration in the conventional theory of quantum transitions based on using the notion of probability amplitude. As a result, the probability amplitudes lose their physical meaning. All the physical information on quantum dynamics of a system is contained in the mean values of physical quantities. The existence of considerable differences between the quantities W and Π permits one in principle to make a choice of the correct theory of quantum transitions on the basis of experimental data. (author)

  17. Predicting Coronal Mass Ejections transit times to Earth with neural network

    CERN Document Server

    Sudar, D; Dumbović, M

    2015-01-01

    Predicting transit times of Coronal Mass Ejections (CMEs) from their initial parameters is a very important subject, not only from the scientific perspective, but also because CMEs represent a hazard for human technology. We used a neural network to analyse transit times for 153 events with only two input parameters: initial velocity of the CME, $v$, and Central Meridian Distance, CMD, of its associated flare. We found that transit time dependence on $v$ is showing a typical drag-like pattern in the solar wind. The results show that the speed at which acceleration by drag changes to deceleration is $v\\approx$500 km s$^{-1}$. Transit times are also found to be shorter for CMEs associated with flares on the western hemisphere than those originating on the eastern side of the Sun. We attribute this difference to the eastward deflection of CMEs on their path to 1 AU. The average error of the NN prediction in comparison to observations is $\\approx$12 hours which is comparable to other studies on the same subject.

  18. A model for temporal resolution of multidetector computed tomography of coronary arteries in relation to rotation time, heart rate and reconstruction algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Greuter, M.J.W.; Ooijen, P.M.A. van; Oudkerk, M. [University Medical Center Groningen, University of Groningen, Department of Radiology, P.O. Box 30.001, Groningen (Netherlands); Flohr, T. [Siemens Medical Solutions, CT Division, Forchheim (Germany)

    2007-03-15

    A model is presented that describes the image quality of coronary arteries with multidetector computer tomography. The results are discussed in the context of rotation time of the scanner, heart rate, and number of sectors used in the acquisition process. The blurring of the coronary arteries was calculated for heart rates between 50 and 100 bpm for rotation times of 420, 370, and 330 ms, and one-, two-, three-, and four-sector acquisition modes and irregular coronary artery movement is included. The model predicts optimal timing within the RR cycle of 45{+-}3% (RCA), 44{+-}4% and 74{+-}6% (LCX), and 35{+-}4% and 76{+-}5% (LAD). The optimal timing shows a negative linear dependency on heart rate and increases with the number of sectors used. The RCA blurring decreases from 0.98 cm for 420 ms, one-sector mode to 0.27 cm for 330 ms, four-sector mode. The corresponding values are 0.81 cm and 0.29 cm for LCX and 0.42 cm and 0.17 cm for LAD. The number of sectors used in a multisector reconstruction and the timing within the cardiac cycle should be adjusted to the specific coronary artery that has to be imaged. Irregular coronary artery movement of 1.5 mm justifies the statement that no more than two sectors should be used in multisector acquisition processes in order to improve temporal resolution in cardiac MDCT. (orig.)

  19. Synchronization transitions in coupled time-delay electronic circuits with a threshold nonlinearity.

    Science.gov (United States)

    Srinivasan, K; Senthilkumar, D V; Murali, K; Lakshmanan, M; Kurths, J

    2011-06-01

    Experimental observations of typical kinds of synchronization transitions are reported in unidirectionally coupled time-delay electronic circuits with a threshold nonlinearity and two time delays, namely feedback delay τ(1) and coupling delay τ(2). We have observed transitions from anticipatory to lag via complete synchronization and their inverse counterparts with excitatory and inhibitory couplings, respectively, as a function of the coupling delay τ(2). The anticipating and lag times depend on the difference between the feedback and the coupling delays. A single stability condition for all the different types of synchronization is found to be valid as the stability condition is independent of both the delays. Further, the existence of different kinds of synchronizations observed experimentally is corroborated by numerical simulations and from the changes in the Lyapunov exponents of the coupled time-delay systems.

  20. Controlling the transition between Turing and antispiral patterns by using time-delayed-feedback

    Institute of Scientific and Technical Information of China (English)

    He Ya-Feng; Liu Fu-Cheng; Fan Wei-Li; Dong Li-Fang

    2012-01-01

    The controllable transition between Turing and antispiral patterns is studied by using a time-delayed-feedback strategy in a FitzHugh-Nagumo model.We treat the time delay as a perturbation and analyse the effect of the time delay on the Turing and Hopf instabilities near the Turing-Hopf codimension-two phase space.Numerical simulations show that the transition between the Turing patterns (hexagon,stripe,and honeycomb),the dual-mode antispiral,and the antispiral by applying appropriate feedback parameters.The dual-mode antispiral pattern originates from the competition between the Turing and Hopf instabilities.Our results have shown the flexibility of the time delay on controlling the pattern formations near the Turing-Hopf codimension-two phase space.

  1. Transit times of water in soil lysimeters from modelling of oxygen-18

    Energy Technology Data Exchange (ETDEWEB)

    Lindstroem, G.; Rohde, A. (Swedish Meteorological and Hydrological Institute, Norrkoeping (Sweden))

    1992-10-01

    A proper description of water pathways and transit times is important in simulation of groundwater acidification using hydrochemical models. A simple water balance model, describing water flow and transit times in different soil layers, was developed and tested by the use of the stable isotope [sup 18]O as a natural tracer in soil lysimeters. Drainage was collected from lysimeters of three depths: 15, 40, and 80 cm, from two sites in the Stubbetorp research basin in south-eastern Sweden. The content of [sup 18]O in the precipitation and in the drainage from the lysimeters was measured during 2 years. [sup 18]O was regarded as an ideal tracer, and its concentration in the drainage was modeled using the concentration in the precipitation as input. The percolation from each soil layer was assumed to depend on the inflow and the soil moisture storage in the layer. The most important model parameter, the field capacity, was derived from field information. Sensitivity analysis showed that the model was rather insensitive to other parameter values. Although simple, the model gave good results, both for the flow of water and [sup 18]O. The best results were obtained, when ideal mixing in the upper horizons of the soil was combined with piston flow at greater depths. Preferential flow was not found to be of great importance, nor was immobile water. Particle flow velocities and transit times in the soil lysimeters were simulated. The average particle flow velocities were about 0.6 cm d[sup -1]. The use of a dynamic model made it possible to simulate the temporal variations in transit times for water in the soil lysimeters. The mean transit times for the 80 cm lysimeter ranged from about 3 to 6 mo with an average value of 4 mo. 29 refs., 8 figs., 4 tabs.

  2. Establishment of a protocol for determining gastrointestinal transit time in mice using barium and radiopaque markers

    Energy Technology Data Exchange (ETDEWEB)

    Myagmarjaibuu, Bilomaa; Moon, Myeong Ju; Heo, Suk Hee; Jeong, Seo In; Jeong, Yong Yeon; Kang, Heoung Keun [Dept. of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun (Korea, Republic of); Park, Jong Seong [Dept. of Physiology, Chonnam National University Medical School, Gwangju (Korea, Republic of); Jun, Jae Yeoul [Dept. of Physiology, College of Medicine, Chosun University, Gwangju (Korea, Republic of)

    2013-01-15

    The purpose of this study was to establish a minimally invasive and reproducible protocol for estimating the gastrointestinal (GI) transit time in mice using barium and radiopaque markers. Twenty 5- to 6-week-old Balb/C female mice weighing 19-21 g were used. The animals were divided into three groups: two groups that received loperamide and a control group. The control group (n = 10) animals were administered physiological saline (1.5 mL/kg) orally. The loperamide group I (n = 10) and group II (n = 10) animals were administered 5 mg/kg and 10 mg/kg loperamide orally, respectively. Thirty minutes after receiving the saline or loperamide, the mice was administered 80 μL of barium solution and six iron balls (0.5 mm) via the mouth and the upper esophagus by gavage, respectively. Afterwards, the mice were continuously monitored with fluoroscopic imaging in order to evaluate the swallowing of the barium solution and markers. Serial fluoroscopic images were obtained at 5- or 10-min intervals until all markers had been excreted from the anal canal. For analysis, the GI transit times were subdivided into intestinal transit times (ITTs) and colon transit times (CTTs). The mean ITT was significantly longer in the loperamide groups than in the control group (p < 0.05). The mean ITT in loperamide group II (174.5 ± 32.3) was significantly longer than in loperamide group I (133.2 ± 24.2 minute) (p < 0.05). The mean CTT was significantly longer in loperamide group II than in the control group (p < 0.05). Also, no animal succumbed to death after the experimental procedure. The protocol for our study using radiopaque markers and barium is reproducible and minimally invasive in determining the GI transit time of the mouse model.

  3. Amplification of Quantum Meson Modes in the Late Time of the Chiral Phase Transition

    CERN Document Server

    Watanabe, K

    2007-01-01

    We investigate the time evolution of the quantum meson modes in the late time of chiral phase transition. In particular, it is shown that there exists a possible solution to the equation of motion for the quantum meson modes, which reveals a parametric resonance and/or resonance through forced oscillation induced by the small oscillation of the chiral condensate. After that, we demonstrate the unstable regions for the quantum meson modes in both the cases of a uniform and spatially expanding system.

  4. Robust Blind Frequency and Transition Time Estimation for Frequency Hopping Systems

    OpenAIRE

    Kuo-Ching Fu; Yung-Fang Chen

    2010-01-01

    In frequency hopping spread spectrum (FHSS) systems, two major problems are timing synchronization and frequency estimation. A blind estimation scheme is presented for estimating frequency and transition time without using reference signals. The scheme is robust in the sense that it can avoid the unbalanced sampling block problem that occurs in existing maximum likelihood-based schemes, which causes large errors in one of the estimates of frequency. The proposed scheme has a lower computatio...

  5. Late time cosmological phase transitions 1: Particle physics models and cosmic evolution

    Science.gov (United States)

    Frieman, Joshua A.; Hill, Christopher T.; Watkins, Richard

    1991-01-01

    We described a natural particle physics basis for late-time phase transitions in the universe. Such a transition can seed the formation of large-scale structure while leaving a minimal imprint upon the microwave background anisotropy. The key ingredient is an ultra-light pseudo-Nambu-Goldstone boson with an astronomically large (O(kpc-Mpc)) Compton wavelength. We analyze the cosmological signatures of and constraints upon a wide class of scenarios which do not involve domain walls. In addition to seeding structure, coherent ultra-light bosons may also provide unclustered dark matter in a spatially flat universe, omega sub phi approx. = 1.

  6. Time-dependent renormalized Redfield theory II for off-diagonal transition in reduced density matrix

    Science.gov (United States)

    Kimura, Akihiro

    2016-09-01

    In our previous letter (Kimura, 2016), we constructed time-dependent renormalized Redfield theory (TRRT) only for diagonal transition in a reduced density matrix. In this letter, we formulate the general expression for off-diagonal transition in the reduced density matrix. We discuss the applicability of TRRT by numerically comparing the dependencies on the energy gap of the exciton relaxation rate by using the TRRT and the modified Redfield theory (MRT). In particular, we roughly show that TRRT improves MRT for the detailed balance about the excitation energy transfer reaction.

  7. Martensitic phase transition in UNi{sub 2}Sn measured in two time scales

    Energy Technology Data Exchange (ETDEWEB)

    Drost, A. [Netherlands Energy Research Foundation (ECN), Petten (Netherlands); Mulder, F.M. [Rijksuniversiteit Leiden (Netherlands). Kamerlingh Onnes Lab.; Thiel, R.C. [Rijksuniversiteit Leiden (Netherlands). Kamerlingh Onnes Lab.; Frikkee, E. [Netherlands Energy Research Foundation (ECN), Petten (Netherlands); Nieuwenhuys, G.J. [Rijksuniversiteit Leiden (Netherlands). Kamerlingh Onnes Lab.

    1994-08-01

    The martensitic phase transition in the Heusler compound UNi{sub 2}Sn has been investigated by means of neutron powder diffraction and {sup 119}Sn Moessbauer spectroscopy. It is shown that the low-temperature orthorhombic structure is gradually transformed into the high-temperature cubic structure between 200 and 330 K. Although the Moessbauer spectra for these two phases are virtually identical, an extraordinary line broadening is observed in the transition region. The broadening is explained in terms of the thermal excitation of domain walls, moving on the Moessbauer time scale. In the domain walls the atoms hop from cubic to orthorhombic position or vice versa. (orig.).

  8. Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.

    Science.gov (United States)

    Yuan, Kai; Seller, Charles A; Shermoen, Antony W; O'Farrell, Patrick H

    2016-08-01

    At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes. PMID:27339317

  9. Radiographic analysis of the effect of dietary fibers on rat colonic transit time

    Energy Technology Data Exchange (ETDEWEB)

    Lupton, J.R.; Meacher, M.M. (Texas A M Univ., College Station (USA))

    1988-11-01

    The effect of different fiber sources on colonic transit time was charted using serial radiographs. Sixty male Sprague-Dawley rats, 10 rats per group, were provided with either a fiber-free control diet or the control diet uniformly diluted to provide 8% dietary fiber from guar, pectin, cellulose, wheat bran, or oat bran. At surgery, radiopaque markers were inserted at defined distances in the mesentary closest to the large bowel. Three weeks postsurgery, the animals were intubated with 0.5 ml of a radiopaque marker, and radiographs were taken at 15-min intervals. Of the two poorly fermented fibers, cellulose was as slow as and wheat bran was faster than the fiber-free controls at five out of the six bowel segments measured. The fermentable fibers (pectin, guar, and oat bran) were fast through some bowel segments and slow through others. This study provides in vivo data on colonic transit time and shows that neither 24-h fecal weight nor total transit time is a good predictor of the rate of transit through particular gut segments.

  10. Radiographic analysis of the effect of dietary fibers on rat colonic transit time

    International Nuclear Information System (INIS)

    The effect of different fiber sources on colonic transit time was charted using serial radiographs. Sixty male Sprague-Dawley rats, 10 rats per group, were provided with either a fiber-free control diet or the control diet uniformly diluted to provide 8% dietary fiber from guar, pectin, cellulose, wheat bran, or oat bran. At surgery, radiopaque markers were inserted at defined distances in the mesentary closest to the large bowel. Three weeks postsurgery, the animals were intubated with 0.5 ml of a radiopaque marker, and radiographs were taken at 15-min intervals. Of the two poorly fermented fibers, cellulose was as slow as and wheat bran was faster than the fiber-free controls at five out of the six bowel segments measured. The fermentable fibers (pectin, guar, and oat bran) were fast through some bowel segments and slow through others. This study provides in vivo data on colonic transit time and shows that neither 24-h fecal weight nor total transit time is a good predictor of the rate of transit through particular gut segments

  11. Nanosecond-scale timing jitter in transition edge sensors at telecom and visible wavelengths

    CERN Document Server

    Lamas-Linares, Antia; Tomlin, Nathan A; Gerrits, Thomas; Lita, Adriana E; Beyer, Joern; Mirin, Richard P; Nam, Sae Woo

    2013-01-01

    Transition edge sensors (TES) have the highest reported efficiencies (>98%) for detection of single photons in the visible and near infrared. Experiments in quantum information and foundations of physics that rely critically on this efficiency have started incorporating these detectors into con- ventional quantum optics setups. However, their range of applicability has been hindered by slow operation both in recovery time and timing jitter. We show here how a conventional tungsten-TES can be operated with jitter times of < 4 ns, well within the timing resolution necessary for MHz clocking of experiments, and providing an important practical simplification for experiments that rely on the simultaneous closing of both efficiency and locality loopholes.

  12. Universal space-time scaling symmetry in the dynamics of bosons across a quantum phase transition

    CERN Document Server

    Clark, Logan W; Chin, Cheng

    2016-01-01

    The dynamics of many-body systems spanning condensed matter, cosmology, and beyond is hypothesized to be universal when the systems cross continuous phase transitions. The universal dynamics is expected to satisfy a scaling symmetry of space and time with the crossing rate, inspired by the Kibble-Zurek mechanism. We test this symmetry based on Bose condensates in a shaken optical lattice. Shaking the lattice drives condensates across an effectively ferromagnetic quantum phase transition. After crossing the critical point, the condensates manifest delayed growth of spin fluctuations and develop anti-ferromagnetic spatial correlations resulting from sub-Poisson generation of topological defects. The characteristic times and lengths scale as power-laws of the crossing rate, yielding the temporal exponent 0.50(2) and the spatial exponent 0.26(2), consistent with theory. Furthermore, the fluctuations and correlations are invariant in scaled space-time coordinates, in support of the scaling symmetry of quantum crit...

  13. The Weibull - log Weibull transition of interoccurrence times for synthetic and natural earthquakes

    CERN Document Server

    Hasumi, Tomohiro; Akimoto, Takuma; Aizawa, Yoji

    2008-01-01

    We have studied interoccurrence time distributions by analyzing the synthetic and three natural catalogs of the Japan Meteorological Agency (JMA), the Southern California Earthquake Data Center (SCEDC), and Taiwan Central Weather Bureau (TCWB) and revealed the universal feature of the interoccurrence time statistics, Weibull - log Weibull transition. This transition reinforces the view that the interoccurrence time statistics possess Weibull statistics and log-Weibull statistics. Here in this paper, the crossover magnitude from the superposition regime to the Weibull regime $m_c^2$ is proportional to the plate velocity. In addition, we have found the region-independent relation, $m_c^2/m_{max} = 0.54 \\pm 0.004$.

  14. Accelerating the transit time of barium sulphate suspensions in small bowel examinations

    International Nuclear Information System (INIS)

    Purpose: To determine whether hyperosmolar and effervescent agents proven individually to accelerate transit time in the barium small bowel examination have an additive effect when combined, surpassing that of either agent alone. Materials and methods: One hundred and forty-nine patients were randomised to four groups. Three hundred milliliters of barium sulphate alone was given to the first group. Fifteen milliliters of iodinated hyperosmolar contrast agent (Gastrografin, meglumine/sodium diatrizoate, Schering) was given in addition to barium sulphate to the second group while six packets of effervescent granules (Carbex, Ferring) were added for the third group. The final group was given a combination of both additives and barium sulphate. The time taken following ingestion for the contrast column to reach the caecum, as assessed by frequent interval fluoroscopy, was recorded. A subgroup of 32 patients were selected randomly from the four groups, 8 from each and assessed for quality of examination. Statistical assessments were made using Kruskal-Wallis and Mann-Whitney tests. Results: One hundred and nineteen patients were analysed after exclusions. The addition of accelerant to barium sulphate, both individually and in combination significantly reduced the small bowel transit time (p < 0.001). No significant difference existed between the additives when used with barium alone. The combined group had significantly faster transit times compared to the hyperosmolar group (p = 0.02). Differences between combined and effervescent groups tended towards significance (p = 0.09). No significant difference existed between groups when examination quality was assessed. Conclusion: These results suggest that the addition of combined effervescent and hyperosmolar agents to the barium suspension may significantly shorten the small bowel transit time without adversely affecting examination quality. This has implications for patient acceptability of the examination as well as

  15. Image Fusion of Preprocedural CTA with Real-time Fluoroscopy to Guide Proper Hepatic Artery Catheterization During Transarterial Chemoembolization of Hepatocellular Carcinoma: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Bargellini, Irene, E-mail: irenebargellini@hotmail.com; Turini, Francesca; Bozzi, Elena; Lauretti, Dario; Cicorelli, Antonio; Lunardi, Alessandro; Cioni, Roberto; Bartolozzi, Carlo [University of Pisa, Department of Diagnostic and Interventional Radiology (Italy)

    2013-04-15

    To assess feasibility of proper hepatic artery catheterization using a 3D model obtained from preprocedural computed tomographic angiography (CTA), fused with real-time fluoroscopy, during transarterial chemoembolization of hepatocellular carcinoma. Twenty consecutive cirrhotic patients with hepatocellular carcinoma undergoing transarterial chemoembolization were prospectively enrolled onto the study. The early arterial phase axial images of the preprocedural CTA were postprocessed on an independent workstation connected to the angiographic system (Innova 4100; GE Healthcare, Milwaukee, WI), obtaining a 3D volume rendering image (VR) that included abdominal aorta, splanchnic arteries, and first and second lumbar vertebrae. The VR image was manually registered to the real-time X-ray fluoroscopy, with the lumbar spine used as the reference. The VR image was then used as guidance to selectively catheterize the proper hepatic artery. The procedure was considered successful when performed with no need for intraarterial contrast injections or angiographic acquisitions. The procedure was successful in 19 (95 %) of 20 patients. In one patient, celiac trunk angiography was required for the presence of a significant ostial stenosis that was underestimated at computed tomography. Time for image reconstruction and registration was <10 min in all cases. The use of preprocedural CTA model with fluoroscopy enables confident and direct catheterization of the proper hepatic artery with no need for preliminary celiac trunk angiography, thus reducing radiation exposure and contrast media administration.

  16. Transition times and stochastic resonance for multidimensional diffusions with time periodic drift: A large deviations approach

    OpenAIRE

    Herrmann, Samuel; Imkeller, Peter; Peithmann, Dierk

    2006-01-01

    We consider potential type dynamical systems in finite dimensions with two meta-stable states. They are subject to two sources of perturbation: a slow external periodic perturbation of period $T$ and a small Gaussian random perturbation of intensity $\\epsilon$, and, therefore, are mathematically described as weakly time inhomogeneous diffusion processes. A system is in stochastic resonance, provided the small noisy perturbation is tuned in such a way that its random trajectories follow the ex...

  17. Observation of parity-time symmetry breaking transitions in a dissipative Floquet system of ultracold atoms

    CERN Document Server

    Li, Jiaming; Liu, Ji; de Melo, Leonardo; Joglekar, Yogesh N; Luo, Le

    2016-01-01

    Open physical systems with balanced loss and gain exhibit a transition, absent in their solitary counterparts, which engenders modes that exponentially decay or grow with time and thus spontaneously breaks the parity-time PT symmetry. This PT-symmetry breaking is induced by modulating the strength or the temporal profile of the loss and gain, but also occurs in a pure dissipative system without gain. It has been observed that, in classical systems with mechanical, electrical, and electromagnetic setups with static loss and gain, the PT-symmetry breaking transition leads to extraordinary behavior and functionalities. However, its observation in a quantum system is yet to be realized. Here we report on the first quantum simulation of PT-symmetry breaking transitions using ultracold Li-6 atoms. We simulate static and Floquet dissipative Hamiltonians by generating state-dependent atom loss in a noninteracting Fermi gas, and observe the PT-symmetry breaking transitions by tracking the atom number for each state. W...

  18. The mass of the Mars-sized exoplanet Kepler-138 b from transit timing.

    Science.gov (United States)

    Jontof-Hutter, Daniel; Rowe, Jason F; Lissauer, Jack J; Fabrycky, Daniel C; Ford, Eric B

    2015-06-18

    Extrasolar planets that pass in front of their host star (transit) cause a temporary decrease in the apparent brightness of the star, providing a direct measure of the planet's size and orbital period. In some systems with multiple transiting planets, the times of the transits are measurably affected by the gravitational interactions between neighbouring planets. In favourable cases, the departures from Keplerian orbits (that is, unaffected by gravitational effects) implied by the observed transit times permit the planetary masses to be measured, which is key to determining their bulk densities. Characterizing rocky planets is particularly difficult, because they are generally smaller and less massive than gaseous planets. Therefore, few exoplanets near the size of Earth have had their masses measured. Here we report the sizes and masses of three planets orbiting Kepler-138, a star much fainter and cooler than the Sun. We determine that the mass of the Mars-sized inner planet, Kepler-138 b, is 0.066(+0.059)(-0.037) Earth masses. Its density is 2.6(+2.4)(-1.5) grams per cubic centimetre. The middle and outer planets are both slightly larger than Earth. The middle planet's density (6.2(+5.8)(-3.4) grams per cubic centimetre) is similar to that of Earth, and the outer planet is less than half as dense at 2.1(+2.2)(-1.2) grams per cubic centimetre, implying that it contains a greater portion of low-density components such as water and hydrogen.

  19. Simplified assessment of segmental gastrointestinal transit time with orally small amount of barium

    International Nuclear Information System (INIS)

    Objective: To determine the effectiveness and advantage of small amount of barium in the measurement of gastrointestinal transmission function in comparison with radio-opaque pallets. Methods: Protocal 1: 8 healthy volunteers (male 6, female 2) with average age 40 ± 6.1 were subjected to the examination of radio-opaque pellets and small amount of barium with the interval of 1 week. Protocol 2: 30 healthy volunteers in group 1 (male 8, female 22) with average age 42.5 ± 8.1 and 50 patients with chronic functional constipation in group 2 (male 11, female 39) with average age 45.7 ± 7.8 were subjected to the small amount of barium examination. The small amount of barium was made by 30 g barium dissolved in 200 ml breakfast. After taking breakfast which contains barium, objectives were followed with abdominal X-ray at 4, 8, 12, 24, 48, 72, 96 h until the barium was evacuated totally. Results: Small amount of barium presented actual chyme or stool transit. The transit time of radio-opaque pallets through the whole gastrointestinal tract was significantly shorter than that of barium (37 ± 8 h vs. 47 ± 10 h, P < 0.05) in healthy people. The transit times of barium in constipation patients were markedly prolonged in colon (61.1 ± 22 vs. 37.3 ± 11, P < 0.01) and rectum (10.8 ± 3.7 vs. 2.3 ± 0.8 h, P < 0.01) compared with unconstipated volunteers. Transit times in individual gastrointestinal segments were also recorded by using small amount of barium, which allowed identifying the subtypes of constipation. Conclusion: The small amount barium examination is a convenient and low cost method to provide the most useful and reliable information on the transmission function of different gastrointestinal segments and able to classify the subtypes of slow transit constipation

  20. The 9 May 2016 Mercury transit – a timely opportunity for outreach

    Science.gov (United States)

    Rothery, David; Benkhoff, Johannes; Zender, Joe; Gill, Ranpal

    2015-04-01

    People across most of the globe will have a chance to witness Mercury's next solar transit, 11:12-18:42 UT, Monday 9 May 2016. Occurring a year after the end of the MESSENGER mission and a few months before the launch of BepiColombo, this transit (the first since 2006) will be an ideal occasion to draw the public's attention to the science goals of those missions, to showcase what we have recently learned about Mercury, and to draw attention to the conundrums that make Mercury such a fascinating object to study. The 2004 and 2012 transits of Venus were accompanied by major outreach events, and stimulated day-long media interest. The 2016 Mercury transit offers a similar opportunity, which the Mercury science community should seize upon. It is especially timely as an occasion to showcase the science achieved by MESSENGER and planned for BepiColombo. As a bonus, outreach infrastructure and momentum should still be fresh enough to re-use for the next transit, on 11 Nov 2019 (after that there will be a 13-year gap until 2032). Inexpensive solar projectors adequate to show the transit are readily available, and a recent upsurge of amateurs posting H-alpha and Ca-K solar images via social media shows that the amateur astronomy community is well-equipped to observe the Sun. Provisional plans for Mercury transit day 2016 are to webstream images for the benefit of those in darkness or afflicted by cloud, taking images from satellites such as PROBA-2 and SOHO as well as ground-based observatories. We will also webstream interviews and features about Mercury itself, to show what a fascinating world BepiColombo will be visiting. We would like to encourage observatories and astronomical societies to invite the public to view the transit using their facilities, and hope to be able to provide an on-line searchable list of transit events so members of the public can find one nearby.

  1. Estimation of coronary artery stenosis by low-dose adenosine stress real-time myocardial contrast echocardiography: a quantitative study

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xiao; ZHI Guang; XU Yong; WANG Jing; YAN Guo-hui

    2012-01-01

    Background Coronary microcirculation reserve is an important field in the research of coronary artery disease,but it is difficult to identify clinically.Currently it is widely accepted that myocardial contrast echocardiography (MCE) is a safe,inexpensive method and has comparatively high image resolution.The present study used quantitative low-dose adenosine stress real-time (RT)-MCE to estimate myocardial perfusion and the coronary stenosis.Methods Forty-nine left ventricular (LV) segments from 14 unselected patients were divided into three groups according to the coronary angiography or CT angiography results:group 1 (n=20,41%) without significant stenosis (<70%),group 2 (n=12,24%)with successful percutaneous coronary intervention (PCI),and group 3 (n=17,35%)with significant stenosis (>70%).RT-MCE was performed in these patients with low-dose adenosine stress and continuous infusion of Sonovue.The replenishing curves were drawn according to the contrast density measured at the end-diastolic frame of every cardiac circle by ACQ software.Results Forty-nine LV segments with satisfactory image quality were picked for quantitative contrast echo analysis.The replenishing curves were analyzed at baseline and after stress.Perfusion of group 3 did not decrease significantly at baseline,and showed no improvement during adenosine stress and was significantly different from groups 1 and 2 (P <0.05).The A·β and β increased more significantly in group 1 than in groups 2 and 3 (P <0.05).In a receiver operating characteristic (ROC) curve analysis,A·β under adenosine stress <1.74 dB/s had a sensitivity and specificity of 71% for diagnosis of coronary artery stenosis,reduced adenosine-induced rise (percentage of A·β <81%) had a sensitivity and specificity of 83% and 79% for the diagnosis of low-reserve,and β <54% had a sensitivity of 86% and specificity of 79%.Conclusions Rest perfusion of severely stenosed arteries may be normal

  2. Transition from lognormal to χ2-superstatistics for financial time series

    Science.gov (United States)

    Xu, Dan; Beck, Christian

    2016-07-01

    Share price returns on different time scales can be well modelled by a superstatistical dynamics. Here we provide an investigation which type of superstatistics is most suitable to properly describe share price dynamics on various time scales. It is shown that while χ2-superstatistics works well on a time scale of days, on a much smaller time scale of minutes the price changes are better described by lognormal superstatistics. The system dynamics thus exhibits a transition from lognormal to χ2 superstatistics as a function of time scale. We discuss a more general model interpolating between both statistics which fits the observed data very well. We also present results on correlation functions of the extracted superstatistical volatility parameter, which exhibits exponential decay for returns on large time scales, whereas for returns on small time scales there are long-range correlations and power-law decay.

  3. Transition from phase to generalized synchronization in time-delay systems.

    Science.gov (United States)

    Senthilkumar, D V; Lakshmanan, M; Kurths, J

    2008-06-01

    The notion of phase synchronization in time-delay systems, exhibiting highly non-phase-coherent attractors, has not been realized yet even though it has been well studied in chaotic dynamical systems without delay. We report the identification of phase synchronization in coupled nonidentical piecewise linear and in coupled Mackey-Glass time-delay systems with highly non-phase-coherent regimes. We show that there is a transition from nonsynchronized behavior to phase and then to generalized synchronization as a function of coupling strength. We have introduced a transformation to capture the phase of the non-phase-coherent attractors, which works equally well for both the time-delay systems. The instantaneous phases of the above coupled systems calculated from the transformed attractors satisfy both the phase and mean frequency locking conditions. These transitions are also characterized in terms of recurrence-based indices, namely generalized autocorrelation function P(t), correlation of probability of recurrence, joint probability of recurrence, and similarity of probability of recurrence. We have quantified the different synchronization regimes in terms of these indices. The existence of phase synchronization is also characterized by typical transitions in the Lyapunov exponents of the coupled time-delay systems.

  4. Particle Identification: Time-of-Flight, Cherenkov and Transition Radiation Detectors - Particle Detectors and Detector Systems

    CERN Document Server

    Ullaland, O

    2011-01-01

    Particle Identification: Time-of-Flight, Cherenkov and Transition Radiation Detectors in 'Particle Detectors and Detector Systems', part of 'Landolt-Börnstein - Group I Elementary Particles, Nuclei and Atoms: Numerical Data and Functional Relationships in Science and Technology, Volume 21B1: Detectors for Particles and Radiation. Part 1: Principles and Methods'. This document is part of Part 1 'Principles and Methods' of Subvolume B 'Detectors for Particles and Radiation' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the Section '3.3 Particle Identification: Time-of-Flight, Cherenkov and Transition Radiation Detectors' of Chapter '3 Particle Detectors and Detector Systems' with the content: 3.3 Particle Identification: Time-of-Flight, Cherenkov and Transition Radiation Detectors 3.3.1 Introduction 3.3.2 Time of Flight Measurements 3.3.2.1 Scintillator hodoscopes 3.3.2.2 Parallel plate ToF detectors 3.3.3 Cherenkov Radiation 3.3.3.1 ...

  5. Wavelength dependent measurements of optical fiber transit time, material dispersion, and attenuation

    Energy Technology Data Exchange (ETDEWEB)

    COCHRANE,KYLE ROBERT; BAILEY,JAMES E.; LAKE,PATRICK WAYNE; CARLSON,ALAN L.

    2000-04-18

    A new method for measuring the wavelength dependence of the transit time, material dispersion, and attenuation of an optical fiber is described. The authors inject light from a 4-ns risetime pulsed broad-band flashlamp into various length fibers and record the transmitted signals with a time-resolved spectrograph. Segments of data spanning an approximately 3,000 {angstrom} range are recorded from a single flashlamp pulse. Comparison of data acquired with short and long fibers enables the determination of the transit time and the material dispersion as functions of wavelength dependence for the entire recorded spectrum simultaneously. The wavelength dependent attenuation is also determined from the signal intensities. The method is demonstrated with experiments using a step index 200-{micro}m-diameter SiO{sub 2} fiber. The results agree with the transit time determined from the bulk glass refractive index to within {+-} 0.035% for the visible (4,000--7,200 {angstrom}) spectrum and 0.12% for the ultraviolet (2,650--4,000 {angstrom}) spectrum, and with the attenuation specified by the fiber manufacturer to within {+-} 10%.

  6. Markov transition probability-based network from time series for characterizing experimental two-phase flow

    Institute of Scientific and Technical Information of China (English)

    Gao Zhong-Ke; Hu Li-Dan; Jin Ning-De

    2013-01-01

    We generate a directed weighted complex network by a method based on Markov transition probability to represent an experimental two-phase flow.We first systematically carry out gas-liquid two-phase flow experiments for measuring the time series of flow signals.Then we construct directed weighted complex networks from various time series in terms of a network generation method based on Markov transition probability.We find that the generated network inherits the main features of the time series in the network structure.In particular,the networks from time series with different dynamics exhibit distinct topological properties.Finally,we construct two-phase flow directed weighted networks from experimental signals and associate the dynamic behavior of gas-liquid two-phase flow with the topological statistics of the generated networks.The results suggest that the topological statistics of two-phase flow networks allow quantitative characterization of the dynamic flow behavior in the transitions among different gas-liquid flow patterns.

  7. Transit Timing Observations from Kepler: IV. Confirmation of 4 Multiple Planet Systems by Simple Physical Models

    Energy Technology Data Exchange (ETDEWEB)

    Fabrycky, Daniel C.; /UC, Santa Cruz; Ford, Eric B.; /Florida U.; Steffen, Jason H.; /Fermilab; Rowe, Jason F.; /SETI Inst., Mtn. View /NASA, Ames; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Moorhead, Althea V.; /Florida U.; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Bryson, Steve; /NASA, Ames; Buchhave, Lars A.; /Bohr Inst. /Copenhagen U.; Christiansen, Jessie L.; /SETI Inst., Mtn. View /NASA, Ames /Caltech

    2012-01-01

    Eighty planetary systems of two or more planets are known to orbit stars other than the Sun. For most, the data can be sufficiently explained by non-interacting Keplerian orbits, so the dynamical interactions of these systems have not been observed. Here we present 4 sets of lightcurves from the Kepler spacecraft, which each show multiple planets transiting the same star. Departure of the timing of these transits from strict periodicity indicates the planets are perturbing each other: the observed timing variations match the forcing frequency of the other planet. This confirms that these objects are in the same system. Next we limit their masses to the planetary regime by requiring the system remain stable for astronomical timescales. Finally, we report dynamical fits to the transit times, yielding possible values for the planets masses and eccentricities. As the timespan of timing data increases, dynamical fits may allow detailed constraints on the systems architectures, even in cases for which high-precision Doppler follow-up is impractical.

  8. Robust Blind Frequency and Transition Time Estimation for Frequency Hopping Systems

    Directory of Open Access Journals (Sweden)

    Fu Kuo-Ching

    2010-01-01

    Full Text Available In frequency hopping spread spectrum (FHSS systems, two major problems are timing synchronization and frequency estimation. A blind estimation scheme is presented for estimating frequency and transition time without using reference signals. The scheme is robust in the sense that it can avoid the unbalanced sampling block problem that occurs in existing maximum likelihood-based schemes, which causes large errors in one of the estimates of frequency. The proposed scheme has a lower computational cost than the maximum likelihood-based greedy search method. The estimated parameters are also used for the subsequent time and frequency tracking. The simulation results demonstrate the efficacy of the proposed approach.

  9. Robust Blind Frequency and Transition Time Estimation for Frequency Hopping Systems

    Science.gov (United States)

    Fu, Kuo-Ching; Chen, Yung-Fang

    2010-12-01

    In frequency hopping spread spectrum (FHSS) systems, two major problems are timing synchronization and frequency estimation. A blind estimation scheme is presented for estimating frequency and transition time without using reference signals. The scheme is robust in the sense that it can avoid the unbalanced sampling block problem that occurs in existing maximum likelihood-based schemes, which causes large errors in one of the estimates of frequency. The proposed scheme has a lower computational cost than the maximum likelihood-based greedy search method. The estimated parameters are also used for the subsequent time and frequency tracking. The simulation results demonstrate the efficacy of the proposed approach.

  10. U(1) gauge theory over discrete space-time and phase transitions

    OpenAIRE

    Hu, L. Z.

    2000-01-01

    We first apply Connes' noncommutative geometry to a finite point space. The explicit form of the action functional of U(1) gauge field on this n-point space is obtained. We then consider the case when the n-point space is replaced by {space-time}\\times{n-point space}. This action is shown to relate the Hamiltonian of the continuous-spin formulation of the Potts model. We argue that U(1) gauge theory on the discrete space-time determines the geometric origin of a class of phase transitions.

  11. Graft patency in off-pump and conventional coronary artery bypass grafting for treatment of triple vessel coronary disease

    Institute of Scientific and Technical Information of China (English)

    胡盛寿; 王小启; 宋云虎; 吕锋

    2003-01-01

    Objective To compare graft patency in off-pump and conventional coronary artery bypass grafting by using the transit time flow meter in the treatment of triple vessel coronary artery disease. Methods Between June 2000 and April 2001, 60 patients with triple vessel coronary artery disease underwent coronary artery bypass grafting. They were divided into two groups: off-pump and conventional coronary artery bypass. All completed grafts were tested intraoperatively using Transit Time Flow Measurement (TTFM). Preoperative and postoperative variables of the two groups were also compared. Results There were no significant differences in sex, age, weight, acute or remote myocardial infarction, hypertension, diabetes and type of bypass grafts between the two groups. The number of bypass grafts and the assisted respiratory time of the off-pump coronary artery bypass grafting (OPCAB) group were significantly less than those of the conventional coronary artery bypass grafting (CCABG) group. The flow and pulsatile index (PI) of the left anterior descending artery bypass grafts and the right coronary artery bypass grafts were not significantly different between the OPCAB and CCABG groups. The flow of OM in the CCABG group with the multiple anastomosis site of sequential grafts was higher than that in the OPCAB group. Diffused narrow coronary artery bypass grafts in both groups had less flow.Conclusion No signficant differences in graft patency were observed in patients with triple vessel coronary artery disease who had undergone OPCAB or CCABG.

  12. Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate

    Energy Technology Data Exchange (ETDEWEB)

    Buttafava, Mauro, E-mail: mauro.buttafava@polimi.it; Boso, Gianluca; Ruggeri, Alessandro; Tosi, Alberto [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Dalla Mora, Alberto [Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy)

    2014-08-15

    We present the design and characterization of a complete single-photon counting module capable of time-gating a silicon single-photon avalanche diode with ON and OFF transition times down to 110 ps, at repetition rates up to 80 MHz. Thanks to this sharp temporal filtering of incoming photons, it is possible to reject undesired strong light pulses preceding (or following) the signal of interest, allowing to increase the dynamic range of optical acquisitions up to 7 decades. A complete experimental characterization of the module highlights its very flat temporal response, with a time resolution of the order of 30 ps. The instrument is fully user-configurable via a PC interface and can be easily integrated in any optical setup, thanks to its small and compact form factor.

  13. Pulmonary blood volume and transit time in cirrhosis: relation to lung function

    DEFF Research Database (Denmark)

    Møller, Søren; Burchardt, H; Øgard, CG;

    2006-01-01

    not been determined separately we assessed PBV and pulmonary transit time (PTT) in relation to lung function in patients with cirrhosis and in controls. METHODS: Pulmonary and cardiac haemodynamics and transit times were determined by radionuclide techniques in 22 patients with alcoholic cirrhosis......BACKGROUND/AIMS: In cirrhosis a systemic vasodilatation leads to an abnormal distribution of the blood volume with a contracted central blood volume. In addition, the patients have a ventilation/perfusion imbalance with a low diffusing capacity. As the size of the pulmonary blood volume (PBV) has...... and in 12 controls. The lung function including diffusing capacity for carbon monoxide (DL, CO) was determined by conventional single breath technique. RESULTS: In the patients, PTT was shorter, 3.9+/-1.2 vs 5.7+/-1.0 s in the controls, P

  14. Pulmonary blood volume and transit time in cirrhosis: relation to lung function

    DEFF Research Database (Denmark)

    Møller, Søren; Burchardt, H; Øgard, CG;

    2006-01-01

    BACKGROUND/AIMS: In cirrhosis a systemic vasodilatation leads to an abnormal distribution of the blood volume with a contracted central blood volume. In addition, the patients have a ventilation/perfusion imbalance with a low diffusing capacity. As the size of the pulmonary blood volume (PBV) has...... not been determined separately we assessed PBV and pulmonary transit time (PTT) in relation to lung function in patients with cirrhosis and in controls. METHODS: Pulmonary and cardiac haemodynamics and transit times were determined by radionuclide techniques in 22 patients with alcoholic cirrhosis and...... cirrhosis. The relation between PBV and PTT and the low diffusing capacity suggests the pulmonary vascular compartment as an important element in the pathophysiology of the lung dysfunction in cirrhosis....

  15. Transition from anticipatory to lag synchronization via complete synchronization in time-delay systems.

    Science.gov (United States)

    Senthilkumar, D V; Lakshmanan, M

    2005-01-01

    The existence of anticipatory, complete, and lag synchronization in a single system having two different time delays, that is, feedback delay tau1 and coupling delay tau2, is identified. The transition from anticipatory to complete synchronization and from complete to lag synchronization as a function of coupling delay tau2 with a suitable stability condition is discussed. In particular, it is shown that the stability condition is independent of the delay times tau1 and tau2. Consequently, for a fixed set of parameters, all the three types of synchronizations can be realized. Further, the emergence of exact anticipatory, complete, or lag synchronization from the desynchronized state via approximate synchronization, when one of the system parameters (b2) is varied, is characterized by a minimum of the similarity function and the transition from on-off intermittency via periodic structure in the laminar phase distribution.

  16. Lagrangian Descriptors of Thermalized Transition States on Time-Varying Energy Surfaces

    Science.gov (United States)

    Craven, Galen T.; Hernandez, Rigoberto

    2015-10-01

    Thermalized chemical reactions driven under dynamical load are characteristic of activated dynamics for arbitrary nonautonomous systems. Recent generalizations of transition state theory to obtain formally exact rates have required the construction of a time-dependent transition state trajectory. Here, we show that Lagrangian descriptors can be used to obtain this structure directly. By developing a phase space separatrix that is void of recrossings, these constructs allow for the principal criterion in the implementation of modern rate theories to be satisfied. Thus, the reactive flux over a time-varying barrier can be determined without ambiguity in chemical reactions. The generality of the formalism suggests that this approach is applicable to any activated system subjected to arbitrary driving and thermal fluctuations.

  17. Lagrangian Descriptors of Thermalized Transition States on Time-Varying Energy Surfaces.

    Science.gov (United States)

    Craven, Galen T; Hernandez, Rigoberto

    2015-10-01

    Thermalized chemical reactions driven under dynamical load are characteristic of activated dynamics for arbitrary nonautonomous systems. Recent generalizations of transition state theory to obtain formally exact rates have required the construction of a time-dependent transition state trajectory. Here, we show that Lagrangian descriptors can be used to obtain this structure directly. By developing a phase space separatrix that is void of recrossings, these constructs allow for the principal criterion in the implementation of modern rate theories to be satisfied. Thus, the reactive flux over a time-varying barrier can be determined without ambiguity in chemical reactions. The generality of the formalism suggests that this approach is applicable to any activated system subjected to arbitrary driving and thermal fluctuations. PMID:26551825

  18. Thresholds for the slope ratio in determining transition time and quantifying diffuser performance in situ

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho; Jacobsen, Finn; Brunskog, Jonas

    2012-01-01

    This study is concerned with an objective measure called the slope ratio that can detect acoustic defects due to unexpected pressure increases such as strong reflections and coincidental constructive interference. The slope ratio is the ratio of the instantaneous slope to the mean slope in a decay...... curve. The slope ratio was suggested for determining the room acoustic transition time experimentally, but its threshold criteria have not been thoroughly investigated. The thresholds for the slope ratio, particularly for applications such as determining the room acoustic transition time and quantifying...... in situ diffuseness, are examined for various room impulse responses. For the tested rooms, a slope ratio threshold of 11 gives the most consistent and systematic results....

  19. Realization of a multipath ultrasonic gas flowmeter based on transit-time technique.

    Science.gov (United States)

    Chen, Qiang; Li, Weihua; Wu, Jiangtao

    2014-01-01

    A microcomputer-based ultrasonic gas flowmeter with transit-time method is presented. Modules of the flowmeter are designed systematically, including the acoustic path arrangement, ultrasound emission and reception module, transit-time measurement module, the software and so on. Four 200 kHz transducers forming two acoustic paths are used to send and receive ultrasound simultaneously. The synchronization of the transducers can eliminate the influence caused by the inherent switch time in simple chord flowmeter. The distribution of the acoustic paths on the mechanical apparatus follows the Tailored integration, which could reduce the inherent error by 2-3% compared with the Gaussian integration commonly used in the ultrasonic flowmeter now. This work also develops timing modules to determine the flight time of the acoustic signal. The timing mechanism is different from the traditional method. The timing circuit here adopts high capability chip TDC-GP2, with the typical resolution of 50 ps. The software of Labview is used to receive data from the circuit and calculate the gas flow value. Finally, the two paths flowmeter has been calibrated and validated on the test facilities for air flow in Shaanxi Institute of Measurement & Testing. PMID:23809902

  20. Time course of arterial remodelling in diameter and wall thickness above and below the lesion after a spinal cord injury

    NARCIS (Netherlands)

    Thijssen, D.H.J.; Groot, P.C. de; Bogerd, A. van den; Veltmeijer, M.; Cable, N.T.; Green, D.J.; Hopman, M.T.E.

    2012-01-01

    Physical inactivity in response to a spinal cord injury (SCI) represents a potent stimulus for conduit artery remodelling. Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by syste

  1. Transit time of a freely-falling quantum particle in a background gravitational field

    OpenAIRE

    Davies, P.C.W.

    2004-01-01

    Using a model quantum clock, I evaluate an expression for the time of a non-relativistic quantum particle to transit a piecewise geodesic path in a background gravitational field with small spacetime curvature (gravity gradient), in the case that the apparatus is in free fall. This calculation complements and extends an earlier one (Davies 2004) in which the apparatus is fixed to the surface of the Earth. The result confirms that, for particle velocities not too low, the quantum and classical...

  2. Microstructural indicators of transition mechanisms in time-dependent fatigue crack growth in nickel base superalloys

    Science.gov (United States)

    Heeter, Ann E.

    Gas turbine engines are an important part of power generation in modern society, especially in the field of aerospace. Aerospace engines are design to last approximately 30 years and the engine components must be designed to survive for the life of the engine or to be replaced at regular intervals to ensure consumer safety. Fatigue crack growth analysis is a vital component of design for an aerospace component. Crack growth modeling and design methods date back to an origin around 1950 with a high rate of accuracy. The new generation of aerospace engines is designed to be efficient as possible and require higher operating temperatures than ever seen before in previous generations. These higher temperatures place more stringent requirements on the material crack growth performance under creep and time dependent conditions. Typically the types of components which are subject to these requirements are rotating disk components which are made from advanced materials such as nickel base superalloys. Traditionally crack growth models have looked at high temperature crack growth purely as a function of temperature and assumed that all crack growth was either controlled by a cycle dependent or time dependent mechanism. This new analysis is trying to evaluate the transition between cycle-dependent and time-dependent mechanism and the microstructural markers that characterize this transitional behavior. The physical indications include both the fracture surface morphology as well as the shape of the crack front. The research will evaluate whether crack tunneling occurs and whether it consistently predicts a transition from cycle-dependent crack growth to time-dependent crack growth. The study is part of a larger research program trying to include the effects of geometry, mission profile and environmental effects, in addition to temperature effects, as a part of the overall crack growth system. The outcome will provide evidence for various transition types and correlate those

  3. Drainage structures and transit-time distributions in conduit-dominated and fissured karst aquifer systems

    OpenAIRE

    Lauber, Ute

    2014-01-01

    Karst aquifers are important groundwater resources. Solutionally-enlarged conduits embedded in a fissured rock matrix result in a highly heterogeneous underground drainage pattern that makes karst aquifers difficult to characterize. This thesis emphasizes the identification of drainage structures and the quantification of related transit-time distributions of diverse karst aquifer systems. Applied methods include artificial tracer tests, natural tracer analysis, and discharge analysis.

  4. Time-Averaged Behaviour at the Critical Parameter Point of Transition to Spatiotemporal Chaos

    Institute of Scientific and Technical Information of China (English)

    贺凯芬

    2001-01-01

    A time-averaged behaviour is found to be important for investigating the critical behaviour in parameter space for the transition from temporal chaos to spatiotemporal chaos by using an energy representation. Considering any wave solution as a superposition of the steady wave with its perturbation wave, we find that when approaching the critical parameter point the averaged positive interaction energy for the k = 1 mode becomes competitive with the negative one, with the summation displaying a scaling behaviour of power law.

  5. Influence of orocaecal transit time on hydrogen excretion after carbohydrate malabsorption

    DEFF Research Database (Denmark)

    Rumessen, J J; Hamberg, O; Gudmand-Høyer, E

    1989-01-01

    The aim of the present study was to determine whether changes in orocaecal transit time (OCTT) affect the magnitude of the breath hydrogen (H2) excretion after ingestion of unabsorbable carbohydrate. We studied eight healthy subjects by interval sampling of end expiratory H2 concentration for 12 ...... studies estimates of the degree of carbohydrate malabsorption on the basis of breath H2 concentration may be valid in spite of differences in OCTT....

  6. Efficient Transition Probability Computation for Continuous-Time Branching Processes via Compressed Sensing

    OpenAIRE

    Xu, Jason; Minin, Vladimir N.

    2015-01-01

    Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the discrete state space is large or uncountable. Classical methods such as matrix exponentiation are infeasible for large or countably infinite state spaces, and sampling-based alternatives are computationally intensive, requiring integration over all possible...

  7. Stability and Stabilization of Continuous-Time Markovian Jump Singular Systems with Partly Known Transition Probabilities

    OpenAIRE

    2014-01-01

    This paper investigates the problem of the stability and stabilization of continuous-time Markovian jump singular systems with partial information on transition probabilities. A new stability criterion which is necessary and sufficient is obtained for these systems. Furthermore, sufficient conditions for the state feedback controller design are derived in terms of linear matrix inequalities. Finally, numerical examples are given to illustrate the effectiveness of the proposed methods.

  8. Stability and Stabilization of Continuous-Time Markovian Jump Singular Systems with Partly Known Transition Probabilities

    Directory of Open Access Journals (Sweden)

    Jumei Wei

    2014-01-01

    Full Text Available This paper investigates the problem of the stability and stabilization of continuous-time Markovian jump singular systems with partial information on transition probabilities. A new stability criterion which is necessary and sufficient is obtained for these systems. Furthermore, sufficient conditions for the state feedback controller design are derived in terms of linear matrix inequalities. Finally, numerical examples are given to illustrate the effectiveness of the proposed methods.

  9. Measuring space-time variation of the fundamental constants with redshifted submillimetre transitions of neutral carbon

    OpenAIRE

    Curran, S. J.; Tanna, A.; Koch, F. E.; Berengut, J. C.; Webb, J K; Stark, A. A.; Flambaum, V. V.

    2011-01-01

    We compare the redshifts of neutral carbon and carbon monoxide in the redshifted sources in which the fine structure transition of neutral carbon, [CI], has been detected, in order to measure space-time variation of the fundamental constants. Comparison with the CO rotational lines measures gives the same combination of constants obtained from the comparison fine structure line of singly ionised carbon, [CII]. However, neutral carbon has the distinct advantage that it may be spatially coincid...

  10. Method of optical self-mixing for pulse wave transit time in comparison with other methods and correlation with blood pressure

    Science.gov (United States)

    Meigas, Kalju; Lass, Jaanus; Kattai, Rain; Karai, Deniss; Kaik, Juri

    2004-07-01

    This paper is a part of research to develop convenient method for continuous monitoring of arterial blood pressure by non-invasive and non-oscillometric way. A simple optical method, using self-mixing in a diode laser, is used for detection of skin surface vibrations near the artery. These vibrations, which can reveal the pulsate propagation of blood pressure waves along the vasculature, are used for pulse wave registration. The registration of the Pulse Wave Transit Time (PWTT) is based on computing the time delay in different regions of the human body using an ECG as a reference signal. In this study, the comparison of method of optical self-mixing with other methods as photoplethysmographic (PPG) and bioimpedance (BI) for PWTT is done. Also correlation of PWTT, obtained with different methods, with arterial blood pressure is calculated. In our study, we used a group of volunteers (34 persons) who made the bicycle exercise test. The test consisted of cycling sessions of increasing workloads during which the HR changed from 60 to 180 beats per minute. In addition, a blood pressure (NIBP) was registered with standard sphygmomanometer once per minute during the test and all NIBP measurement values were synchronized to other signals to find exact time moments where the systolic blood pressure was detected (Korotkoff sounds starting point). Computer later interpolated the blood pressure signal in order to get individual value for every heart cycle. The other signals were measured continuously during all tests. At the end of every session, a recovery period was included until person's NIBP and heart rate (HR) normalized. As a result of our study it turned out that time intervals that were calculated from plethysmographic (PPG) waveforms were in the best correlation with systolic blood pressure. The diastolic pressure does not correlate with any of the parameters representing PWTT. The pulse wave signals measured by laser and piezoelectric transducer are very similar

  11. Mean Transit Time as a Predictor of Groundwater Discharge Response in the Upper Colorado River Basin

    Science.gov (United States)

    Solder, J. E.; Heilweil, V. M.; Stolp, B. J.; Susong, D.

    2015-12-01

    The Colorado River and its tributaries support 40 million municipal water users and 5.5 million acres of agriculture in the south western United States (U.S. Bureau of Reclamation, 2012). Recent estimates by Rumsey et al. (2015) suggest that a significant portion (about 50 percent) of surface water flow in the Upper Colorado River Basin (UCRB) is sustained by groundwater discharge to streams. Predicted climate variation (Cook et al., 2015) and increased water demand (U.S. Bureau of Reclamation, 2012) within the UCRB suggest future decreases in groundwater discharge, however transient groundwater responses are not well understood. In this study we calculate groundwater mean transit time (MTT) and transit time distribution (TTD) as predictors of the pattern and timing of groundwater response to hydraulic stress. Samples from nineteen large springs within the UCRB were analyzed for environmental tracers to determine MTT and TTD. The predictive value of the MTT is examined by a statistical analysis of MTT, historical spring discharge records, and the Palmer Hydrological Drought Index. MTTs of the 19 springs range from 10 to 15,000 years with a flow-weighted average of 1,650 years. The composite TTD of the 19 springs suggest that flowpaths representing 45 percent of their combined discharge have transit times greater than 100 years. However, spring discharge records indicate that flow responds to drought on much shorter (0.5 - 6 year) time scales, indicative of a hydraulic pressure response. Springs with shorter MTTs (Manga, 1999) has shown groundwater responds on shorter time scales than the MTT, but of interest the results presented here indicate that relatively stable and old springs with long MTTs (> 100) also show a hydraulic pressure response. While not fully representative of the UCRB, results from the 19 springs indicate that groundwater discharge responds to climate variation and water-demand imbalances over a relatively short time period of years.

  12. Influence of temperature on transit times and microwave noise performances of SiGe HBT

    International Nuclear Information System (INIS)

    The influence of temperature (300 K and 40 K) on intrinsic transit times and microwave noise performances of silicon germanium (SiGe) heterojunction bipolar transistors (HBTs) is investigated. At 300 K, we compared measured and modelled S-parameters and four noise parameters, and we found a good agreement. At 40 K, we compared measured and modelled S-parameters, and we deduced noise performances from the S-parameter measurements. The electric model includes correlated junction noise sources and a proper extraction of the transit times involved in these sources. Moreover, the microwave noise model considers all the physical phenomena that impact noise performances in SiGe HBTs. We analysed three devices having different Ge content (10%–20%, 10%–25% and 10%–30%). At 40 K, the device with 10%–25% reaches one of the lowest base transit times (τ B), the lowest minimum noise figure (NFmin), and the lowest equivalent noise resistance (R n), for operation frequencies up to the maximum device dynamic performances (f ≈ f T) These results demonstrate the excellent potential to develop cryogenic applications of SiGe HBTs. (paper)

  13. Influence of temperature on transit times and microwave noise performances of SiGe HBT

    Science.gov (United States)

    Diaz-Albarran, L. M.; Ramirez-Garcia, E.; Zerounian, N.; Aniel, F.; Rodriguez-Mendez, L. M.; Valdez-Perez, D.; Galaz-Larios, M. C.; Enciso-Aguilar, M. A.

    2016-03-01

    The influence of temperature (300 K and 40 K) on intrinsic transit times and microwave noise performances of silicon germanium (SiGe) heterojunction bipolar transistors (HBTs) is investigated. At 300 K, we compared measured and modelled S-parameters and four noise parameters, and we found a good agreement. At 40 K, we compared measured and modelled S-parameters, and we deduced noise performances from the S-parameter measurements. The electric model includes correlated junction noise sources and a proper extraction of the transit times involved in these sources. Moreover, the microwave noise model considers all the physical phenomena that impact noise performances in SiGe HBTs. We analysed three devices having different Ge content (10%-20%, 10%-25% and 10%-30%). At 40 K, the device with 10%-25% reaches one of the lowest base transit times (τ B), the lowest minimum noise figure (NFmin), and the lowest equivalent noise resistance (R n), for operation frequencies up to the maximum device dynamic performances (f ≈ f T) These results demonstrate the excellent potential to develop cryogenic applications of SiGe HBTs.

  14. A New Method for Increasing Output Power of a Three-Cavity Transit-Time Oscillator

    Institute of Scientific and Technical Information of China (English)

    HE Jun-Tao; ZHONG Hui-Huang; QIAN Bao-Liang; LIU Yong-Gui

    2004-01-01

    We propose a new method to increase the output power of a three-cavity transit-time oscillator (TC-TTO).Conventional transit-time effect oscillators, such as the split-cavity oscillator (SCO), super-Reltron, and TC-TTO (or double-foil SCO), etc., have a common feature that the span of any modulating cavity is uniform. The new method is to vary the three-cavity spans from uniform to nonuniform. Its configuration is called the nonuniform three-cavity transit-time oscillator (NTC-TTO). Numerical simulations show that the electron-beam is modulated more deeply in certain NTC-TTOs than that in the TC-TTO with the same whole modulating length, and the output microwave power in certain NTC-TTOs is higher than that in the TC-TTO. The experimental results are in agreement with those of the numerical simulations. The results show that the new method can increase the output power of a microwave tube based on the TC-TTO.

  15. H/L transition time estimation in JET using conformal predictors

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S., E-mail: sergio.gonzalez@ciemat.es [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Murari, A. [Consorzio RFX, Associazione EURATOM/ENEA per la Fusione, Padova 4-25127 (Italy); Pereira, A. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Dormido-Canto, S.; Ramirez, J.M. [Departamento de Informatica y Automatica, UNED, Madrid 28040 (Spain)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer H/L transitions have been predicted using H/L and L/H models. Black-Right-Pointing-Pointer Models have been built using conformal predictors to hedge the prediction with confidence and credibility measures. Black-Right-Pointing-Pointer Models have been trained using linear and radial basis function kernels. Black-Right-Pointing-Pointer Conformal measures have proven their usefulness to validate data-driven models. - Abstract: Recent advances in data mining allow the automatic recognition of physical phenomena in the databases of fusion devices without human intervention. This is important to create large databases of physical events (thereby increasing the statistical relevance) in an unattended manner. Important examples are the L/H and H/L transitions. In this contribution, a novel technique is introduced to automatically locate H/L transitions in JET by using conformal predictors. The focus is on H/L transitions because typically there is not a clear signature in the time series of the most widely available signals to recognize the change of confinement. Conformal predictors hedge their prediction by means of two parameters: confidence and credibility. The technique has been based on binary supervised classifiers to separate the samples of the respective confinement modes. Results with several underlying classifiers are presented.

  16. Quantifying [{sup 18}F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction

    Energy Technology Data Exchange (ETDEWEB)

    Blomberg, Bjoern A. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Odense University Hospital, Department of Nuclear Medicine, Odense (Denmark); Bashyam, Arjun; Ramachandran, Abhinay; Gholami, Saeid; Houshmand, Sina; Salavati, Ali; Werner, Tom; Alavi, Abass [Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States); Zaidi, Habib [Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging, Geneva (Switzerland); University of Groningen, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen (Netherlands)

    2015-08-15

    The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall {sup 18}F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall {sup 18}F-FDG uptake at different imaging time-points. Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after {sup 18}F-FDG administration. For both time-points, uptake of {sup 18}F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUV{sub MAX}) and cSUV{sub MEAN}. The PVE-corrected SUV{sub MEAN} (pvcSUV{sub MEAN}) was also calculated using {sup 18}F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated. At 60 min, pvcSUV{sub MEAN} was on average 3.1 times greater than cSUV{sub MAX} (P <.0001) and 8.5 times greater than cSUV{sub MEAN} (P <.0001). At 180 min, pvcSUV{sub MEAN} was on average 2.6 times greater than cSUV{sub MAX} (P <.0001) and 6.6 times greater than cSUV{sub MEAN} (P <.0001). This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall {sup 18}F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall {sup 18}F-FDG uptake with PET. (orig.)

  17. Effects of skin pressure by clothing on digestion and orocecal transit time of food.

    Science.gov (United States)

    Sone, Y; Kato, N; Kojima, Y; Takasu, N; Tokura, H

    2000-05-01

    In order to reveal the influence of clothing skin pressure on digestion of food through the gastrointestinal tract, we examined the absorption of dietary carbohydrate and orocecal transit time of a test meal by means of a breath hydrogen test on 7 healthy young women. In this experiment, we collected breath samples from the participants wearing loose-fitting experimental garment on the second day of the experiment and from the same participants but wearing an additional tight-fitting girdle on the following day for 16 hours and 9 hours, respectively. Skin pressure applied by a girdle on participant's waist, abdomen and hip region was 15.5 +/- 0.4 mmHg (mean +/- SE), 11.0 +/- 0.2 mmHg, and 13.6 +/- 0.6 mmHg, respectively, and the values were 2-3 times larger than those of the experimental garment. The hydrogen concentration vs. time curve showed that breath hydrogen levels at its peaks (15:00, 15:30, 16:00, 16:30, and 17:00 hr) on the third day of the experiment were significantly higher than those of the corresponding time on the second day (p clothing condition (p hand, the transit time of the test meal for the subjects wearing a girdle did not differ significantly from that for the subjects wearing the garment of less pressure (270 +/- 18 minutes and 263 +/- 21 minutes, respectively). These results indicate that the clothing skin pressure has an inhibitory effect on the absorption of dietary carbohydrate in the small intestine, but no effect on the orocecal transit time of a meal. PMID:10924040

  18. Splitting the scotoperiod: effects on feeding behaviour, intestinal fill and digestive transit time in broiler chickens

    DEFF Research Database (Denmark)

    Duve, Linda Rosager; Steenfeldt, Sanna; Thodberg, Karen;

    2011-01-01

    points (n¼192). Digestive transit time was estimated on d 29 using a chromic oxide marker; production variables and the extent of foot pad dermatitis were also recorded. 4. In the 3 h prior to a scotoperiod, feeding activity increased in chickens from DARK 8 but not DARK 4þ4. This increase was reflected...... in a higher relative content of the crop in DARK 8 at this time. 5. Immediately following the scotoperiod, feeding activity peaked and, although the chickens in DARK 4þ4 expressed more feeding behaviour in the first 20 min after the scotoperiod, the chickens in DARK 8 had overall higher feeding activity...

  19. The volume and time comparison principle and transition probability estimates for random walks

    OpenAIRE

    Telcs, András

    2003-01-01

    This paper presents necessary and sufficient conditions for on- and off-diagonal transition probability estimates for random walks on weighted graphs. On the integer lattice and on may fractal type graphs both the volume of a ball and the mean exit time from a ball are independent of the center, uniform in space. Here the upper estimate is given without such restriction and two-sided estimate is given if the mean exit time is independent of the center but the volume is not.

  20. Transit Timing Observations from Kepler: VII. Confirmation of 27 planets in 13 multiplanet systems via Transit Timing Variations and orbital stability

    CERN Document Server

    Steffen, Jason H; Agol, Eric; Ford, Eric B; Morehead, Robert C; Cochran, William D; Lissauer, Jack J; Adams, Elisabeth R; Borucki, William J; Bryson, Steve; Caldwell, Douglas A; Dupree, Andrea; Jenkins, Jon M; Robertson, Paul; Rowe, Jason F; Seader, Shawn; Thompson, Susan; Twicken, Joseph D

    2012-01-01

    We confirm 27 planets in 13 planetary systems by showing the existence of statistically significant anti-correlated transit timing variations (TTVs), which demonstrates that the planet candidates are in the same system, and long-term dynamical stability, which places limits on the masses of the candidates---showing that they are planetary. %This overall method of planet confirmation was first applied to \\kepler systems 23 through 32. All of these newly confirmed planetary systems have orbital periods that place them near first-order mean motion resonances (MMRs), including 6 systems near the 2:1 MMR, 5 near 3:2, and one each near 4:3, 5:4, and 6:5. In addition, several unconfirmed planet candidates exist in some systems (that cannot be confirmed with this method at this time). A few of these candidates would also be near first order MMRs with either the confirmed planets or with other candidates. One system of particular interest, Kepler-56 (KOI-1241), is a pair of planets orbiting a 12th magnitude, giant sta...

  1. Incremental value of live/real time three-dimensional over two-dimensional transesophageal echocardiography in the evaluation of right coronary artery fistula.

    Science.gov (United States)

    Mishra, Jaymala; Puri, Hari Prakash; Hsiung, Ming C; Misra, Stuti; Khairnar, Prakash; Laxmi Gollamudi, Bhargavi; Patel, Adilahmed; Nanda, Navin C; Yin, Wei-Hsian; Wei, Jeng; Tsai, Shen-Kou; Sudhakar, Selvin

    2011-08-01

    We report an adult with a right coronary artery to right atrial fistula in whom live/real time three-dimensional transesophageal echocardiography with its ability to trace the entire course and obtain en face views of the fistula connections, was able to provide significant incremental information over two-dimensional transesophageal echocardiography. PMID:21752093

  2. Transit timing variations for planets co-orbiting in the horseshoe regime

    Energy Technology Data Exchange (ETDEWEB)

    Vokrouhlický, David [Institute of Astronomy, Charles University, V Holešovičkách 2, CZ-18000 Prague 8 (Czech Republic); Nesvorný, David, E-mail: vokrouhl@cesnet.cz, E-mail: davidn@boulder.swri.edu [Department of Space Studies, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States)

    2014-08-10

    Although not yet detected, pairs of exoplanets in 1:1 mean motion resonance probably exist. Low eccentricity, near-planar orbits, which in the comoving frame follow horseshoe trajectories, are one of the possible stable configurations. Here we study transit timing variations (TTVs) produced by mutual gravitational interaction of planets in this orbital architecture, with the goal to develop methods that can be used to recognize this case in observational data. In particular, we use a semi-analytic model to derive parametric constraints that should facilitate data analysis. We show that characteristic traits of the TTVs can directly constrain the (1) ratio of planetary masses and (2) their total mass (divided by that of the central star) as a function of the minimum angular separation as seen from the star. In an ideal case, when transits of both planets are observed and well characterized, the minimum angular separation can also be inferred from the data. As a result, parameters derived from the observed transit timing series alone can directly provide both planetary masses scaled to the central star mass.

  3. Transit Timing Variations for Planets Co-orbiting in the Horseshoe Regime

    Science.gov (United States)

    Vokrouhlický, David; Nesvorný, David

    2014-08-01

    Although not yet detected, pairs of exoplanets in 1:1 mean motion resonance probably exist. Low eccentricity, near-planar orbits, which in the comoving frame follow horseshoe trajectories, are one of the possible stable configurations. Here we study transit timing variations (TTVs) produced by mutual gravitational interaction of planets in this orbital architecture, with the goal to develop methods that can be used to recognize this case in observational data. In particular, we use a semi-analytic model to derive parametric constraints that should facilitate data analysis. We show that characteristic traits of the TTVs can directly constrain the (1) ratio of planetary masses and (2) their total mass (divided by that of the central star) as a function of the minimum angular separation as seen from the star. In an ideal case, when transits of both planets are observed and well characterized, the minimum angular separation can also be inferred from the data. As a result, parameters derived from the observed transit timing series alone can directly provide both planetary masses scaled to the central star mass.

  4. Phase transitions in the common brainstem and related systems investigated by nonstationary time series analysis.

    Science.gov (United States)

    Lambertz, M; Vandenhouten, R; Grebe, R; Langhorst, P

    2000-01-14

    Neuronal activities of the reticular formation (RF) of the lower brainstem and the nucleus tractus solitarii (NTS, first relay station of baroreceptor afferents) were recorded together in the anesthized dog with related parameters of EEG, respiration and cardiovascular system. The RF neurons are part of the common brainstem system (CBS) which participates in regulation and coordination of cardiovascular, respiratory, somatomotor systems, and vigilance. Multiple time series of these physiological subsystems yield useful information about internal dynamic coordination of the organism. Essential problems are nonlinearity and instationarity of the signals, due to the dynamic complexity of the systems. Several time-resolving methods are presented to describe nonlinear dynamic couplings in the time course, particularly during phase transitions. The methods are applied to the recorded signals representing the complex couplings of the physiological subsystems. Phase transitions in these systems are detected by recurrence plots of the instationary signals. The pointwise transinformation and the pointwise conditional coupling divergence are measures of the mutual interaction of the subsystems in the state space. If the signals show marked rhythms, instantaneous frequencies and their shiftings are demonstrated by time frequency distributions, and instantaneous phase differences show couplings of oscillating subsystems. Transient signal components are reconstructed by wavelet packet time selective transient reconstruction. These methods are useful means for analyzing coupling characteristics of the complex physiological system, and detailed analyses of internal dynamic coordination of subsystems become possible. During phase transitions of the functional organization (a) the rhythms of the central neuronal activities and the peripheral systems are altered, (b) changes in the coupling between CBS neurons and cardiovascular signals, respiration and the EEG, and (c) between NTS

  5. Time-resolved lattice measurements of shock-induced phase transitions in polycrystalline materials

    Science.gov (United States)

    Milathianaki, Despina

    The response of materials under extreme temperature and pressure conditions is a topic of great significance because of its relevance in astrophysics, geophysics, and inertial confinement fusion. In recent years, environments exceeding several hundred gigapascals in pressure have been produced in the laboratory via laser-based dynamic loading techniques. Shock-loading is of particular interest as the shock provides a fiducial for measuring time-dependent processes in the lattice such as phase transitions. Time-resolved x-ray diffraction is the only technique that offers an insight into these shock-induced processes at the relevant spatial (atomic) and temporal scales. In this study, nanosecond resolution x-ray diffraction techniques were developed and implemented towards the study of shock-induced phase transitions in polycrystalline materials. More specifically, the capability of a focusing x-ray diffraction geometry in high-resolution in situ lattice measurements was demonstrated by probing shock-compressed Cu and amorphous metallic glass samples. In addition, simultaneous lattice and free surface velocity measurements of shock-compressed Mg in the ambient hexagonal close packed (hcp) and shock-induced body centered cubic (bcc) phases between 12 and 45 GPa were performed. These measurements revealed x-ray diffraction signals consistent with a compressed bcc lattice above a shock pressure of 26.2+/-1.3 GPa, thus capturing for the first time direct lattice evidence of a shock-induced hcp to bcc phase transition in Mg. Our measurement of the hcp-bcc phase boundary in Mg was found to be consistent with the calculated boundary from generalized pseudopotential theory in the pressure and temperature region intersected by the principal shock Hugoniot. Furthermore, the subnanosecond timescale of the phase transition implied by the shock-loading conditions was in agreement with the kinetics of a martensitic transformation. In conclusion, we report on the progress and

  6. Does timing and sequencing of transitions to adulthood make a difference? Stress, smoking, and physical activity among young Australian women.

    Science.gov (United States)

    Bell, Sandra; Lee, Christina

    2006-01-01

    The major changes of the transition to adulthood are argued to be stressful, and health-related behaviors such as smoking and physical activity may be adopted, consolidated, or abandoned at this time. On the other hand, research has suggested that the normative transitions of emerging adulthood, although involving considerable change, may be associated with low stress because they are perceived as both positive and normal at this life stage. This article examines relations between the timing and sequencing of life transitions and stress and health-related behaviors, focusing on the transition to young adulthood among Australian women. A total of 853 women aged 22 to 27 provided information about the timing and sequencing of 6 life transitions: moving out of home, stopping full-time education, starting full-time work, having the first live-in relationship, marriage, and motherhood-and stress, smoking, and physical activity. Most had moved out of home, stopped full-time education, and started full-time work, but only 14% had undertaken all 6 transitions. Overall, 70% of participants had made transitions "in order." Overall, the findings suggest that the relations between timing and sequencing of transitions, and indicators of health, are moderate for smoking, but small for stress and for physical activity. These effects remained after controlling for socioeconomic status of the participants' families of origin. Matching current social norms for the timing and sequencing of life changes may be of less importance for women's well-being than is commonly believed. Although the significant relations between early or "out of order" transitions and smoking are of concern, the smaller relations with stress and with sedentariness suggest that such transitions may have limited negative consequences, and support the view that individuals are active in choosing the life path that is appropriate for them and their circumstances. PMID:17078778

  7. Near-infrared laparoscopy for real-time intra-operative arterial and lymphatic perfusion imaging.

    LENUS (Irish Health Repository)

    Cahill, R A

    2012-02-01

    Multimodal laparoscopic imaging systems possessing the capability for extended spectrum irradiation and visualization within a unified camera system are now available to provide enhanced intracorporeal operative anatomic and dynamic perfusion assessment and potentially augmented patient outcome. While ultraviolet-range energies have limited penetration and hence are probably more useful for endoscopic mucosal interrogation, the near-infrared (NIR) spectrum is of greater potential utility for the purposes of examining inducible fluorescence in abdominopelvic tissue that can be achieved by administration of specific tracer agents, either directly into the circulation (e.g. for anastomotic perfusion assessment at the time of stapling) or into the lymphatic system (e.g. for lymph basin road-mapping and\\/or focussed target nodal assessment). This technology is also capable of supplementing anatomic recognition of the biliary system while implantable fibres can also be inserted intraoperatively for the purpose of safeguarding vital structures such as the oesphagus and ureters especially in difficult reoperations. It is likely that this technological capability will find a clear and common indication in colorectal specialist and general surgical departments worldwide in the near future.

  8. Tracer-derived transit time of the waters in the eastern Nordic Seas

    International Nuclear Information System (INIS)

    The spatial-temporal distribution of the anthropogenic radionuclide 137Cs originating from nuclear bomb testing and the Sellafield reprocessing plant in the Irish Sea is simulated using a global version of the Miami Isopycnic Coordinate Ocean Model (MICOM). The physical model has a horizontal resolution of about 40 km, and it is forced with daily atmospheric reanalysed fields for the period 1948 to 2002. A comparison of the temporal evolution of observed and simulated concentrations of 137Cs has been conducted for the regions east of Scotland, west of central Norway and at the entrance of the Barents Sea. It follows that the annual mean 137Cs concentration signal from the Sellafield discharge reaches the southwestern Barents Sea region in 5 yr, in accordance with available observations. To more accurately assess the age of the caesium-tagged water masses, three additional experiments were performed with an Eulerian age coupled to the evolution of the tracer concentration. It is demonstrated that the transit time depends on the duration of the tracer release history, on the dynamical ocean state and on whether the transit time is derived from the time difference between the release history and the concentration evolution downstream of the release, or as an explicit Eulerian age tracer. The Eulerian age tracer gives a transit time for a Sellafield-like discharge to reach the Barents Sea of 56 months in the 1970s, 52 months in the 1960s and 51 months in the 1980s, and that this difference is strongly governed by the ocean dynamics in the Faeroe-Scotland region

  9. The importance of water transit time and mineral dissolution kinetics for the flux of weathering products

    Science.gov (United States)

    Erlandsson, Martin; Bishop, Kevin; Köhler, Stephan; Amvrosiadi, Nino

    2016-04-01

    Soil mineral weathering is one of the major sources of base cations (BC), which play a dual role for a forest ecosystem; they function both as plant nutrients, and for buffering against acidification of catchment runoff. On a long-term basis, the soil weathering rates will determine the highest sustainable forest productivity without causing acidification. It is believed that the hydrologic residence time play a key role in determining weathering rates on a landscape scale. In this study, we investigate the significance of the water transit residence time (WTT) distribution for the transport of base cations to catchment runoff. By modelling hillslope flowpaths with different transit times, using the geochemical computing code PHREEQC, we demonstrate how in-stream dynamics as exemplified by elemental ratios can be explained by mineral dissolution kinetics and equilibria. Specifically, we hypothesize that equilibrium of plagioclase regulates the delivery of base cations and silica to catchment runoff. These patters can be seen in field data from 10 years of sampling from a nested-catchment, where the Na+/BC and the Si/BC-ratios vary systematically with WTT on both a temporal and a spatial scale. This behavior has implications for the total transport of products from mineral dissolution to catchment runoff. As the water entering the stream is a mixture of water with different transit times, the composition of stream water will not only be dependent on the average WTT, but also on the shape of the WTT distribution. For the base cations associated with minerals that becomes supersaturated or with precipitating secondary phases within the range of WTT, i.e. Na+ and K+, the tails of "old water" of the WRT-distribution will not contribute to any extra transport of these elements. Finally, we use the derived relationships to estimate the transport of weathering products from a forested hillslope, given the modelled WRT distribution.

  10. Effect of fasting on the transit time of 144Ce in the mouse gut

    International Nuclear Information System (INIS)

    Our work with G.I. absorption of actinide elements indicates greater absorption by fasted animals than by animals on regular diets (Weiss and Walburg, undated). Residence time of a metallic compound in the gut may be an important factor influencing G.I. absorption. Cerium-144 (III) chloride was administered by gavage to fasted mice and to mice on regular feed. The G.I. tract was excised, cut into sections, and the activity of each section determined as a function of time after dosing. Our results indicate rapid transit of 144CeCl3 along the empty mouse gut. One hour after dosing, about half the Ce is in the cecal contents; about 40% remains in stomach contents. Twelve hours after dosing, only about 2% remains in the cecum; by 16 hours, almost the entire dose has been cleared from the intestine. Transit times in mice with stomach and intestines containing food were 12 hours longer than in fasted mice. These results lead to the conclusion that factors other than G.I. residence time determine G.I. absorption of actinides in mice

  11. Further Results on Stability Analysis of Discrete-Time Markov Jump Linear Systems with Time-Varying Delay and Partly Known Transition Probabilities

    OpenAIRE

    Xingang Zhao; Jianda Han; Yiwen Zhao

    2015-01-01

    This paper is concerned with the stability analysis of discrete-time Markov jump linear systems (MJLSs) with time-varying delay and partly known transition probabilities. The time delay is varying between lower and upper bounds, and the partly known transition probabilities cover the cases of known, uncertain with known lower and upper bounds, and completely unknown, which is more general than the existing result. Via constructing an appropriate Lyapunov function and employing a new technique...

  12. Real-time ultrasound-tagging to track the 2D motion of the common carotid artery wall in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Zahnd, Guillaume, E-mail: g.zahnd@erasmusmc.nl [Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam 3000 CA (Netherlands); Salles, Sébastien; Liebgott, Hervé; Vray, Didier [Université de Lyon, CREATIS, CNRS UMR 5220, INSERM U1044, INSA-Lyon, Université Lyon 1, Lyon 69100 (France); Sérusclat, André [Department of Radiology, Louis Pradel Hospital, Lyon 69500 (France); Moulin, Philippe [Department of Endocrinology, Louis Pradel Hospital, Hospices Civils de Lyon, Université Lyon 1, Lyon 69100, France and INSERM UMR 1060, Lyon 69500 (France)

    2015-02-15

    Purpose: Tracking the motion of biological tissues represents an important issue in the field of medical ultrasound imaging. However, the longitudinal component of the motion (i.e., perpendicular to the beam axis) remains more challenging to extract due to the rather coarse resolution cell of ultrasound scanners along this direction. The aim of this study is to introduce a real-time beamforming strategy dedicated to acquire tagged images featuring a distinct pattern in the objective to ease the tracking. Methods: Under the conditions of the Fraunhofer approximation, a specific apodization function was applied to the received raw channel data, in real-time during image acquisition, in order to introduce a periodic oscillations pattern along the longitudinal direction of the radio frequency signal. Analytic signals were then extracted from the tagged images, and subpixel motion tracking of the intima–media complex was subsequently performed offline, by means of a previously introduced bidimensional analytic phase-based estimator. Results: The authors’ framework was applied in vivo on the common carotid artery from 20 young healthy volunteers and 6 elderly patients with high atherosclerosis risk. Cine-loops of tagged images were acquired during three cardiac cycles. Evaluated against reference trajectories manually generated by three experienced analysts, the mean absolute tracking error was 98 ± 84 μm and 55 ± 44 μm in the longitudinal and axial directions, respectively. These errors corresponded to 28% ± 23% and 13% ± 9% of the longitudinal and axial amplitude of the assessed motion, respectively. Conclusions: The proposed framework enables tagged ultrasound images of in vivo tissues to be acquired in real-time. Such unconventional beamforming strategy contributes to improve tracking accuracy and could potentially benefit to the interpretation and diagnosis of biomedical images.

  13. Association of rumination time with subclinical ketosis in transition dairy cows.

    Science.gov (United States)

    Kaufman, E I; LeBlanc, S J; McBride, B W; Duffield, T F; DeVries, T J

    2016-07-01

    The objective of this study was to characterize the relationship between rumination and subclinical ketosis (SCK) in transition dairy cows. A study was conducted on 4 commercial dairy farms in eastern Ontario, Canada. A total of 339 Holstein dairy cows (107 primiparous and 232 multiparous) were monitored for rumination activity and SCK from 14 d before calving until 28 d after calving. Rumination was recorded daily using an automated monitoring system. A blood sample was taken from the coccygeal vein of each cow for measurement of β-hydroxybutyrate (BHB) once weekly throughout the 6-wk observation period. Cows with BHB ≥1.2mmol/L in any of the 4 postpartum samples were considered to have SCK. Cases of retained placenta, metritis, milk fever, or mastitis during the study period were also recorded. Cows were categorized into 1 of 4 groups: healthy cows (HLT) that had no SCK or any other recorded health problem (n=139); cows treated for at least one health issue other than SCK (HLT+; n=50); cows with SCK (hyperketonemia; HYK) with no other health problems during transition (n=97); or cows (HYK+) that had SCK and one or more other health problems (n=53). Daily rumination time was summarized by week and comparisons were made between HLT and HYK and HYK+. From 2 wk before calving (wk -2) to 4 wk after calving (wk +4), there was no difference in rumination time (409±9.8min/d) among HLT, HYK, and HYK+ cows in their first lactation. Multiparous cows in HLT spent an average of 459±11.3min/d ruminating from wk -2 to wk +4. Multiparous HYK cows ruminated 25±12.8min/d less than HLT cows, whereas HYK+ cows ruminated 44±15.6min/d less than HLT cows. The largest differences in rumination time between HLT and HYK+ cows were seen during wk -1, +1, and +2, when HYK+ cows ruminated 48±17.2, 73±16.0, and 65±19.4min/d less than HLT cows, respectively. In multiparous cows, increased odds of HYK were associated with greater milk yield in the previous lactation, greater loss of

  14. Transit-Based Emergency Evacuation with Transit Signal Priority in Sudden-Onset Disaster

    Directory of Open Access Journals (Sweden)

    Ciyun Lin

    2016-01-01

    Full Text Available This study presents methods of transit signal priority without transit-only lanes for a transit-based emergency evacuation in a sudden-onset disaster. Arterial priority signal coordination is optimized when a traffic signal control system provides priority signals for transit vehicles along an evacuation route. Transit signal priority is determined by “transit vehicle arrival time estimation,” “queuing vehicle dissipation time estimation,” “traffic signal status estimation,” “transit signal optimization,” and “arterial traffic signal coordination for transit vehicle in evacuation route.” It takes advantage of the large capacities of transit vehicles, reduces the evacuation time, and evacuates as many evacuees as possible. The proposed methods were tested on a simulation platform with Paramics V6.0. To evaluate and compare the performance of transit signal priority, three scenarios were simulated in the simulator. The results indicate that the methods of this study can reduce the travel times of transit vehicles along an evacuation route by 13% and 10%, improve the standard deviation of travel time by 16% and 46%, and decrease the average person delay at a signalized intersection by 22% and 17% when the traffic flow saturation along an evacuation route is 0.81.0, respectively.

  15. Validation of a method to differentiate arterial and venous vessels in CT perfusion data using linear combinations of quantitative time-density curve characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Havla, Lukas; Schneider, Moritz; Dietrich, Olaf [Ludwig-Maximilians-University Hospital Munich, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Munich (Germany); Thierfelder, Kolja M.; Beyer, Sebastian E.; Ertl-Wagner, Birgit; Sommer, Wieland H. [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany)

    2015-10-15

    We aimed to develop and evaluate a new method that reliably differentiates between cerebral arteries and veins using voxel-wise CT-perfusion-derived parameters. Fourteen consecutive patients with suspected stroke but without pathological findings were examined on a multi-detector CT system: 32 dynamic phases (∇t = 1.5 s) during application of 35 mL iomeprol-350 were acquired at 80 kV/200mAs. Three hemodynamic parameters were calculated for 18 arterial and venous vessel segments: A (maximum of the time-density-curve), T (time-to-peak), and W (full-width-at-half-maximum). Using receiver operator characteristic (ROC) curve analysis and Fisher's linear discriminant analysis (FLDA), the performance of every classifier (A, T, W) and of all linear combinations for the differentiation of arterial and venous vessels was determined. A maximum area under the ROC-curve (AUC) of 0.945 (accuracy = 86.8 %) was obtained using the FLDA combination of A and T or the triplet FLDA of A and T and W for the classification of venous and arterial vessels. The best single parameter was T with an AUC of 0.871 (accuracy = 79.0 %), which performed significantly worse than the combination A and T (p < 0.001). Arteries and veins can be accurately differentiated based on dynamic CT perfusion data using the maximum of the time-density curve, its time-to-peak, its width, and FLDA combinations of these parameters, which yield accuracies up to 87 %. (orig.)

  16. Analytical determination of transition time between transient and steady state water infiltration

    Science.gov (United States)

    Lassabatere, Laurent; Angulo-Jaramillo, Rafael; di Prima, Simone; Bagarello, Vincenzo; Iovino, Massimo

    2016-04-01

    The hydraulic characterization of soil hydraulic properties is a prerequisite to the modelling of flow in the vadose zone. Since many years, numerous methods were developed to determine soil hydraulic properties. Many of these methods rely on water infiltration experiments and their analysis using analytical or numerical models. At the beginning, most models were developed for water infiltration at steady state. These models had the advantage to be easy to develop from a theoretical point of view. Yet, many drawbacks remain including the need to wait for a long time, leading to time-consuming experiments, the risk to infiltrate water in large volumes of soil, leading to a response affected by soil variability, and the uncertainty regarding the attainment of steady state (i.e. constant infiltration rate). More recently, infiltration models and mathematical developments addressed the case of consecutive transient and steady states. Yet, one main problem remain. In the field, the operator is never sure about the state of water infiltration data. This paper present analytical formulations for the estimation of a transition time. We consider the model developed by Haverkamp et al. (1994) linking 1D infiltration flux to cumulative infiltration and related approximated expansions. An analytical method based on scaling is proposed to define transition time values in terms of both scaled cumulative infiltration and times. Dimensional times are then calculated for a large variety of soils and initial conditions. These time database can be considered as a relevant tool for the guidance for operators who conduct water infiltration experiments and wants to know when to stop and also for modelers who want to know how to select the data to fit transient or steady state models. Haverkamp, R., Ross, P. J., Smetten, K. R. J., Parlange, J. Y. (1994), Three-dimensional analysis of infiltration from the disc infiltrometer: 2 Physically based infiltration equation. Water Resour. Res

  17. Stochastic Stability for Time-Delay Markovian Jump Systems with Sector-Bounded Nonlinearities and More General Transition Probabilities

    OpenAIRE

    Dan Ye; Quan-Yong Fan; Xin-Gang Zhao; Guang-Hong Yang

    2013-01-01

    This paper is concerned with delay-dependent stochastic stability for time-delay Markovian jump systems (MJSs) with sector-bounded nonlinearities and more general transition probabilities. Different from the previous results where the transition probability matrix is completely known, a more general transition probability matrix is considered which includes completely known elements, boundary known elements, and completely unknown ones. In order to get less conservative criterion, the state a...

  18. Study of phase transitions from short-time non-equilibrium behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Albano, E V; Bab, M A; Baglietto, G; Borzi, R A; Grigera, T S; Loscar, E S; Rodriguez, D E; Rubio Puzzo, M L; Saracco, G P [Instituto de Investigaciones FisicoquImicas Teoricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, c.c. 16, suc. 4, 1900 La Plata (Argentina)

    2011-02-15

    We review recent progress in the understanding of phase transitions and critical phenomena, obtained by means of numerical simulations of the early dynamic evolution of systems prepared at well-specified initial conditions. This field has seen exhaustive scientific research during the last decade, when the renormalization-group (RG) theoretical results obtained at the end of the 1980s were applied to the interpretation of dynamic Monte Carlo simulation results. While the original RG theory is restricted to critical phenomena under equilibrium conditions, numerical simulations have been applied to the study of far-from-equilibrium systems and irreversible phase transitions, the investigation of the behaviour of spinodal points close to first-order phase transitions and the understanding of the early-time evolution of self-organized criticality (SOC) systems when released far form the SOC regime. The present review intends to provide a comprehensive overview of recent applications in those fields, which can give the flavour of the main ideas, methods and results, and to discuss the directions for further studies. All of these numerical results pose new and interesting theoretical challenges that remain as open questions to be addressed by new research in the coming years.

  19. Critical Space-Time Networks and Geometric Phase Transitions from Frustrated Edge Antiferromagnetism

    CERN Document Server

    Trugenberger, Carlo A

    2015-01-01

    Recently I proposed a simple dynamical network model for discrete space-time which self-organizes as a graph with Hausdorff dimension d_H=4. The model has a geometric quantum phase transition with disorder parameter (d_H-d_s) where d_s is the spectral dimension of the dynamical graph. Self-organization in this network model is based on a competition between a ferromagnetic Ising model for vertices and an antiferromagnetic Ising model for edges. In this paper I solve a toy version of this model defined on a bipartite graph in the mean field approximation. I show that the geometric phase transition corresponds exactly to the antiferromagnetic transition for edges, the dimensional disorder parameter of the former being mapped to the staggered magnetization order parameter of the latter. The model has a critical point with long-range correlations between edges, where a continuum random geometry can be defined, exactly as in Kazakov's famed 2D random lattice Ising model but now in any number of dimensions.

  20. Springtime trans-pacific atmospheric transport from east Asia: a transit-time-pdf approach

    Science.gov (United States)

    Holzer, M.; McKendry, I.; Jaffe, D.

    2003-04-01

    The atmosphere is known to episodically transport aerosols, dust, and gaseous pollutants from industrialized south-east Asia, the Gobi desert, and Siberian wild fires to western North America. We give a novel characterization of the ever-present background transport from these regions and of the probability of transport ``events", that is, long-range transport of high concentrations with minimal dispersion. Our primary transport diagnostic is the transit-time probability density function (pdf), {\\cal G}, which is a tracer-independent measure of the flow that allows us to isolate the role of transport from other factors such as source variability and chemistry. The pdf approach, unlike typical back-trajectory analyses, captures transport due to all possible paths and accounts for both resolved advection and subgrid processes. We use a numerical model of the global atmosphere (MATCH), driven by NCEP reananlysis data, to establish the springtime statistics of daily averages of {\\cal G}. A suitably defined average of {\\cal G} quantifies the mass fraction of background air of a given transit time, or age, from the source regions. An analysis of the variability of {\\cal G} at fixed transit time allows us to identify transport events and to estimate their probability of occurrence. This is illustrated for transport events to the ``Pacific-North-West" (PNW) region of North America, defined as (43.8o-53.3o{N}) × (115.3o-124.7o{W}). Correlations between {\\cal G} averaged over the PNW and the winds at any point in the atmosphere identify large-scale anomaly structures of the flow that correspond to favorable transport to the PNW.

  1. Search for Time-Independent Lorentz Violation using Muon Neutrino to Muon Antineutrino Transitions in MINOS

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, P.; et al.

    2016-05-10

    Data from the MINOS experiment has been used to search for mixing between muon neutrinos and muon antineutrinos using a time-independent Lorentz-violating formalism derived from the Standard-Model Extension (SME). MINOS is uniquely capable of searching for muon neutrino-antineutrino mixing given its long baseline and ability to distinguish between neutrinos and antineutrinos on an event-by-event basis. Neutrino and antineutrino interactions were observed in the MINOS Near and Far Detectors from an exposure of 10.56$\\times10^{20}$ protons-on-target from the NuMI neutrino-optimized beam. No evidence was found for such transitions and new, highly stringent limits were placed on the SME coefficients governing them. We place the first limits on the SME parameters $(c_{L})^{TT}_{\\mu\\mu} $ and $(c_{L})^{TT}_{\\tau\\tau}$ at $-8.4\\times10^{-23} < (c_{L})^{TT}_{\\mu\\mu} < 8.0\\times10^{-23}$ and $-8.0\\times10^{-23} < (c_{L})^{TT}_{\\tau\\tau} < 8.4\\times10^{-23}$, and the world's best limits on the $\\tilde{g}^{ZT}_{\\mu\\overline{\\mu}}$ and $\\tilde{g}^{ZT}_{\\tau\\overline{\\tau}}$ parameters at $|\\tilde{g}^{ZT}_{\\mu\\overline{\\mu}}| < 3.3\\times 10^{-23}$ and $|\\tilde{g}^{ZT}_{\\tau\\overline{\\tau}}| < 3.3\\times 10^{-23}$, all limits quoted at $3\\sigma$.

  2. An Investigation of Pulse Transit Time as a Non-Invasive Blood Pressure Measurement Method

    Energy Technology Data Exchange (ETDEWEB)

    McCarthy, B M; O' Flynn, B; Mathewson, A, E-mail: brian.mccarthy@tyndall.ie [Tyndall National Institute, UCC, Lee Maltings, Prospect Row, Cork (Ireland)

    2011-08-17

    The objective of this paper is to examine the Pulse Transit Method (PTT) as a non-invasive means to track Blood Pressure over a short period of time. PTT was measured as the time it takes for an ECG R-wave to propagate to the finger, where it is detected by a photoplethysmograph sensor. The PTT method is ideal for continuous 24-hour Blood Pressure Measurement (BPM) since it is both cuff-less and non-invasive and therefore comfortable and unobtrusive for the patient. Other techniques, such as the oscillometric method, have shown to be accurate and reliable but require a cuff for operation, making them unsuitable for long term monitoring. Although a relatively new technique, the PTT method has shown to be able to accurately track blood pressure changes over short periods of time, after which re-calibration is necessary. The purpose of this study is to determine the accuracy of the method.

  3. An Investigation of Pulse Transit Time as a Non-Invasive Blood Pressure Measurement Method

    Science.gov (United States)

    McCarthy, B. M.; O'Flynn, B.; Mathewson, A.

    2011-08-01

    The objective of this paper is to examine the Pulse Transit Method (PTT) as a non-invasive means to track Blood Pressure over a short period of time. PTT was measured as the time it takes for an ECG R-wave to propagate to the finger, where it is detected by a photoplethysmograph sensor. The PTT method is ideal for continuous 24-hour Blood Pressure Measurement (BPM) since it is both cuff-less and non-invasive and therefore comfortable and unobtrusive for the patient. Other techniques, such as the oscillometric method, have shown to be accurate and reliable but require a cuff for operation, making them unsuitable for long term monitoring. Although a relatively new technique, the PTT method has shown to be able to accurately track blood pressure changes over short periods of time, after which re-calibration is necessary. The purpose of this study is to determine the accuracy of the method.

  4. An Investigation of Pulse Transit Time as a Non-Invasive Blood Pressure Measurement Method

    International Nuclear Information System (INIS)

    The objective of this paper is to examine the Pulse Transit Method (PTT) as a non-invasive means to track Blood Pressure over a short period of time. PTT was measured as the time it takes for an ECG R-wave to propagate to the finger, where it is detected by a photoplethysmograph sensor. The PTT method is ideal for continuous 24-hour Blood Pressure Measurement (BPM) since it is both cuff-less and non-invasive and therefore comfortable and unobtrusive for the patient. Other techniques, such as the oscillometric method, have shown to be accurate and reliable but require a cuff for operation, making them unsuitable for long term monitoring. Although a relatively new technique, the PTT method has shown to be able to accurately track blood pressure changes over short periods of time, after which re-calibration is necessary. The purpose of this study is to determine the accuracy of the method.

  5. Changes in sleep duration, timing, and quality as children transition to kindergarten.

    Science.gov (United States)

    Cairns, Alyssa; Harsh, John

    2014-01-01

    Sleep can be seen as a biologically driven behavior shaped by cultural context. A "poor fit" occurs when contextual demands for the timing and duration sleep periods are incompatible with the underlying biology. Such contextual factors are well-known for adults, yet little is known of the contextual factors that shape young children's sleep health and to what degree such factors impact sleep duration, timing, and quality. This study attempted to identify how the transition to kindergarten was associated with changes in sleep timing, duration, and quality for children enrolled in preschool prior to attending kindergarten vs. those who were not. Wrist actigraphy in 38 5-year-old children was collected at three longitudinal points before and after the start of kindergarten. Our data suggested that the transition to kindergarten was associated with a reduction in weekday sleep (mostly due to lost napping) and an advance in the weekday nocturnal sleep period that was most pronounced for children not enrolled in preschool prior to kindergarten. These sleep changes paralleled objective and caregiver-reported data of increased sleep pressure that lasted well into the first month of kindergarten.

  6. Gas bubble detection in liquid metals by means of the ultrasound transit-time-technique

    International Nuclear Information System (INIS)

    Liquid metals are used in nuclear energy technology and a precise knowledge of the distribution of the gas bubbles and their behaviour inside liquid metals is very useful. In this work the ultrasound-transit time technique is introduced as a versatile method to analyze the bubble dynamics in liquid-metal-gas flows. After discussing the principle of operation and the implementation of the technique, the methods used to extract the positions of the bubbles, their velocities, or their diameters are explained. Finally, the performance of the method is demonstrated for a liquid-metal-gas flow with and without a magnetic field. (authors)

  7. Money, Trust and Happiness in Transition Countries: Evidence from Time Series

    OpenAIRE

    Bartolini, Stefano; Mikucka, Malgorzata; Sarracino, Francesco

    2012-01-01

    The evolution over time of subjective well-being (SWB) in transition countries exhibit some peculiarities: greater variations which are more strongly correlated with the trends of GDP relative to other countries. What is the possible role of social trust in predicting such variations? We compare the capacity of the trends of GDP and of social trust to predict the trends of SWB. We find that the strength of the relationship between social trust and SWB over the medium-term is comparable to tha...

  8. GARUSO - Version 1.0. Uncertainty model for multipath ultrasonic transit time gas flow meters

    Energy Technology Data Exchange (ETDEWEB)

    Lunde, Per; Froeysa, Kjell-Eivind; Vestrheim, Magne

    1997-09-01

    This report describes an uncertainty model for ultrasonic transit time gas flow meters configured with parallel chords, and a PC program, GARUSO Version 1.0, implemented for calculation of the meter`s relative expanded uncertainty. The program, which is based on the theoretical uncertainty model, is used to carry out a simplified and limited uncertainty analysis for a 12`` 4-path meter, where examples of input and output uncertainties are given. The model predicts a relative expanded uncertainty for the meter at a level which further justifies today`s increasing tendency to use this type of instruments for fiscal metering of natural gas. 52 refs., 15 figs., 11 tabs.

  9. Comparison of axial and radial electron beam-breakup transit-time oscillators

    Energy Technology Data Exchange (ETDEWEB)

    Kwan, T.J.T. [Los Alamos National Lab., NM (United States); Mostrom, M.A. [Mission Research Corporation, Albuquerque, NM (United States)

    1995-08-01

    Comparison of two configurations of a novel high-power microwave generator is presented in this article. Coupling the beam-breakup instability with the transit-time effect of the electron beam in the cavity, rapid energy exchange between the electrons and cavity modes can occur. The dominant cavity modes in the axial and radial configurations are different but their growth rates are comparable. We found that the radial configuration can have a beam impedance less than 10 {Omega} and therefore more suitable for low-voltage and high power operation. Good agreements have been obtained between linear theory and simulation for both configurations.

  10. Residual circulation trajectories and transit times into the extratropical lowermost stratosphere

    Directory of Open Access Journals (Sweden)

    T. Birner

    2010-07-01

    Full Text Available Transport into the extratropical lowermost stratosphere (LMS can be divided into a slow part (time-scale of several months to years associated with the global-scale stratospheric residual circulation and a fast part (time-scale of days to a few months associated with (mostly quasi-horizontal mixing (i.e. two-way irreversible transport, including stratosphere-troposphere exchange. The stratospheric residual circulation can be considered to consist of two branches: a deep branch more strongly associated with planetary waves breaking in the middle to upper stratosphere, and a shallow branch more strongly associated with synoptic-scale waves breaking in the subtropical lower stratosphere. In this study the contribution due to the stratospheric residual circulation alone to transport into the LMS is quantified using residual circulation trajectories, i.e. trajectories driven by the (time-dependent residual mean meridional and vertical velocities. This contribution represents the advective part of the overall transport into the LMS and can be viewed as providing a background onto which the effect of mixing has to be added. Residual mean velocities are obtained from a comprehensive chemistry-climate model as well as from reanalysis data. Transit times of air traveling from the tropical tropopause to the LMS along the residual circulation streamfunction are evaluated and compared to recent mean age of air estimates. A clear time-scale separation with much smaller transit times into the mid-latitudinal LMS than into polar LMS is found that is indicative of a clear separation of the shallow from the deep branch of the residual circulation. This separation between the shallow and the deep circulation branch is further manifested in a clear distinction in the aspect ratio of the vertical to meridional extent of the trajectories as well as the integrated mass flux along the residual circulation trajectories. The residual transit time distribution reproduces

  11. Residual circulation trajectories and transit times into the extratropical lowermost stratosphere

    Directory of Open Access Journals (Sweden)

    T. Birner

    2011-01-01

    Full Text Available Transport into the extratropical lowermost stratosphere (LMS can be divided into a slow part (time-scale of several months to years associated with the global-scale stratospheric residual circulation and a fast part (time-scale of days to a few months associated with (mostly quasi-horizontal mixing (i.e. two-way irreversible transport, including extratropical stratosphere-troposphere exchange. The stratospheric residual circulation may be considered to consist of two branches: a deep branch more strongly associated with planetary waves breaking in the middle to upper stratosphere, and a shallow branch associated with synoptic and planetary scale waves breaking in the subtropical lower stratosphere. In this study the contribution due to the stratospheric residual circulation alone to transport into the LMS is quantified using residual circulation trajectories, i.e. trajectories driven by the (time-dependent residual mean meridional and vertical velocities. This contribution represents the advective part of the overall transport into the LMS and can be viewed as providing a background onto which the effect of mixing has to be added. Residual mean velocities are obtained from a comprehensive chemistry-climate model as well as from reanalysis data. Transit times of air traveling from the tropical tropopause to the LMS along the residual circulation streamfunction are evaluated and compared to recent mean age of air estimates. A time-scale separation with much smaller transit times into the mid-latitudinal LMS than into polar LMS is found that is indicative of a separation of the shallow from the deep branch of the residual circulation. This separation between the shallow and the deep circulation branch is further manifested in a distinction in the aspect ratio of the vertical to meridional extent of the trajectories, the integrated mass flux along the residual circulation trajectories, as well as the stratospheric entry latitude of the trajectories

  12. Transit times of water particles in the vadose zone across catchment states and catchments functional units

    Science.gov (United States)

    Sprenger, Matthias; Weiler, Markus

    2014-05-01

    Understanding the water movement in the vadose zone and its associated transport of solutes are of major interest to reduce nutrient leaching, pollution transport or other risks to water quality. Soil physical models are widely used to asses such transport processes, while the site specific parameterization of these models remains challenging. Inverse modeling is a common method to adjust the soil physical parameters in a way that the observed water movement or soil water dynamics are reproduced by the simulation. We have shown that the pore water stable isotope concentration can serve as an additional fitting target to simulate the solute transport and water balance in the unsaturated zone. In the presented study, the Mualem- van Genuchten parameters for the Richards equation and diffusivity parameter for the convection-dispersion equation have been parameterized using the inverse model approach with Hydrus-1D for 46 experimental sites of different land use, topography, pedology and geology in the Attert basin in Luxembourg. With the best parameter set we simulated the transport of a conservative solute that was introduced via a pulse input at different points in time. Thus, the transit times in the upper 2 m of the soil for different catchment states could be inferred for each location. It has been shown that the time a particle needs to pass the -2 m depth plane highly varies from the systems state and the systems forcing during and after infiltration of that particle. Differences in transit times among the study sites within the Attert basin were investigated with regards to its governing factors to test the concept of functional units. The study shows the potential of pore water stable isotope concentration for residence times and transport analyses in the unsaturated zone leading to a better understanding of the time variable subsurface processes across the catchment.

  13. Direct simulation of groundwater transit-time distributions using the reservoir theory

    Science.gov (United States)

    Etcheverry, David; Perrochet, Pierre

    Groundwater transit times are of interest for the management of water resources, assessment of pollution from non-point sources, and quantitative dating of groundwaters by the use of environmental isotopes. The age of water is the time water has spent in an aquifer since it has entered the system, whereas the transit time is the age of water as it exits the system. Water at the outlet of an aquifer is a mixture of water elements with different transit times, as a consequence of the different flow-line lengths. In this paper, transit-time distributions are calculated by coupling two existing methods, the reservoir theory and a recent age-simulation method. Based on the derivation of the cumulative age distribution over the whole domain, the approach accounts for the whole hydrogeological framework. The method is tested using an analytical example and its applicability illustrated for a regional layered aquifer. Results show the asymmetry and multimodality of the transit-time distribution even in advection-only conditions, due to the aquifer geometry and to the velocity-field heterogeneity. Résumé Les temps de transit des eaux souterraines sont intéressants à connaître pour gérer l'évaluation des ressources en eau dans le cas de pollution à partir de sources non ponctuelles, et aussi pour dater quantitativement les eaux souterraines au moyen des isotopes du milieu. L'âge de l'eau est le temps qu'elle a passé dans un aquifère depuis qu'elle est entrée dans le système, alors que le temps de transit est l'âge de l'eau au moment où elle quitte le système. L'eau à la sortie d'un aquifère est un mélange d'eaux possédant différents temps de transit, du fait des longueurs différentes des lignes de courant suivies. Dans ce papier, les distributions des temps de transit sont calculées en couplant deux méthodes, la théorie du réservoir et une méthode récente de simulation des âges. Basée sur la dérivation de la distribution cumulées des âges sur

  14. The Effects of Positive Discipline Techniques as They Relate to Transition Times in the Middle School Classroom.

    Science.gov (United States)

    Kariuki, Patrick; Davis, Ruth

    This study examined the relationship between positive discipline techniques and classroom transition times in middle-school classrooms. The study sample consisted of four language arts classes with a total of 113 predominantly white eighth-grade students from a northeast Tennessee school system. Data were collected by establishing transition times…

  15. Going through the Rites of Passage: Timing and Transition of Menarche, Childhood Sexual Abuse, and Anxiety Symptoms in Girls

    Science.gov (United States)

    Natsuaki, Misaki N.; Leve, Leslie D.; Mendle, Jane

    2011-01-01

    Menarche is a discrete, transitional event that holds considerable personal, social, biological, and developmental significance. The present longitudinal study examined both the transition and timing of menarche on the trajectory of anxiety in girls with histories of childhood maltreatment (N = 93; 63% European American, 14% multiracial, 10%…

  16. Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

    Science.gov (United States)

    Jimenez, Sergio A; Piera-Velazquez, Sonsoles

    2016-04-01

    Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations. SSc is considered to be the prototypic systemic fibrotic disorder. Despite currently available therapeutic approaches SSc has a high mortality rate owing to the development of SSc-associated interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), complications that have emerged as the most frequent causes of disability and mortality in SSc. The pathogenesis of the fibrotic process in SSc is complex and despite extensive investigation the exact mechanisms have remained elusive. Myofibroblasts are the cells ultimately responsible for tissue fibrosis and fibroproliferative vasculopathy in SSc. Tissue myofibroblasts in SSc originate from several sources including expansion of quiescent tissue fibroblasts and tissue accumulation of CD34+ fibrocytes. Besides these sources, myofibroblasts in SSc may result from the phenotypic conversion of endothelial cells into activated myofibroblasts, a process known as endothelial to mesenchymal transition (EndoMT). Recently, it has been postulated that EndoMT may play a role in the development of SSc-associated ILD and PAH. However, although several studies have described the occurrence of EndoMT in experimentally induced cardiac, renal, and pulmonary fibrosis and in several human disorders, the contribution of EndoMT to SSc-associated ILD and PAH has not been generally accepted. Here, the experimental evidence supporting the concept that EndoMT plays a role in the pathogenesis of SSc-associated ILD and PAH will be reviewed. PMID:26807760

  17. Insights into the water mean transit time in a high-elevation tropical ecosystem

    Science.gov (United States)

    Mosquera, Giovanny M.; Segura, Catalina; Vaché, Kellie B.; Windhorst, David; Breuer, Lutz; Crespo, Patricio

    2016-07-01

    This study focuses on the investigation of the mean transit time (MTT) of water and its spatial variability in a tropical high-elevation ecosystem (wet Andean páramo). The study site is the Zhurucay River Ecohydrological Observatory (7.53 km2) located in southern Ecuador. A lumped parameter model considering five transit time distribution (TTD) functions was used to estimate MTTs under steady-state conditions (i.e., baseflow MTT). We used a unique data set of the δ18O isotopic composition of rainfall and streamflow water samples collected for 3 years (May 2011 to May 2014) in a nested monitoring system of streams. Linear regression between MTT and landscape (soil and vegetation cover, geology, and topography) and hydrometric (runoff coefficient and specific discharge rates) variables was used to explore controls on MTT variability, as well as mean electrical conductivity (MEC) as a possible proxy for MTT. Results revealed that the exponential TTD function best describes the hydrology of the site, indicating a relatively simple transition from rainfall water to the streams through the organic horizon of the wet páramo soils. MTT of the streams is relatively short (0.15-0.73 years, 53-264 days). Regression analysis revealed a negative correlation between the catchment's average slope and MTT (R2 = 0.78, p < 0.05). MTT showed no significant correlation with hydrometric variables, whereas MEC increases with MTT (R2 = 0.89, p < 0.001). Overall, we conclude that (1) baseflow MTT confirms that the hydrology of the ecosystem is dominated by shallow subsurface flow; (2) the interplay between the high storage capacity of the wet páramo soils and the slope of the catchments provides the ecosystem with high regulation capacity; and (3) MEC is an efficient predictor of MTT variability in this system of catchments with relatively homogeneous geology.

  18. Transit Timing Observations from Kepler: II. Confirmation of Two Multiplanet Systems via a Non-parametric Correlation Analysis

    CERN Document Server

    Ford, Eric B; Steffen, Jason H; Carter, Joshua A; Fressin, Francois; Holman, Matthew J; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Ragozzine, Darin; Rowe, Jason F; Welsh, William F; Allen, Christopher; Batalha, Natalie M; Borucki, William J; Bryson, Stephen T; Buchhave, Lars A; Burke, Christopher J; Caldwell, Douglas A; Charbonneau, David; Clarke, Bruce D; Cochran, William D; Désert, Jean-Michel; Endl, Michael; Everett, Mark E; Fischer, Debra A; Gautier, Thomas N; Gilliland, Ron L; Jenkins, Jon M; Haas, Michael R; Horch, Elliott; Howell, Steve B; Ibrahim, Khadeejah A; Isaacson, Howard; Koch, David G; Latham, David W; Li, Jie; Lucas, Philip; MacQueen, Phillip J; Marcy, Geoffrey W; McCauliff, Sean; Mullally, Fergal R; Quinn, Samuel N; Quintana, Elisa; Shporer, Avi; Still, Martin; Tenenbaum, Peter; Thompson, Susan E; Torres, Guillermo; Twicken, Joseph D; Wohler, Bill

    2012-01-01

    We present a new method for confirming transiting planets based on the combination of transit timingn variations (TTVs) and dynamical stability. Correlated TTVs provide evidence that the pair of bodies are in the same physical system. Orbital stability provides upper limits for the masses of the transiting companions that are in the planetary regime. This paper describes a non-parametric technique for quantifying the statistical significance of TTVs based on the correlation of two TTV data sets. We apply this method to an analysis of the transit timing variations of two stars with multiple transiting planet candidates identified by Kepler. We confirm four transiting planets in two multiple planet systems based on their TTVs and the constraints imposed by dynamical stability. An additional three candidates in these same systems are not confirmed as planets, but are likely to be validated as real planets once further observations and analyses are possible. If all were confirmed, these systems would be near 4:6:...

  19. Diagnostic yield of small bowel capsule endoscopy depends on the small bowel transit time

    Institute of Scientific and Technical Information of China (English)

    Jessie Westerhof; Jan J Koornstra; Reinier A Hoedemaker; Wim J Sluiter; Jan H Kleibeuker; Rinse K Weersma

    2012-01-01

    AIM:TO investigate whether the small bowel transit time (SBTT) influences the diagnostic yield of capsule endoscopy (CE).METHODS:Six hundred and ninety-one consecutive CE procedures collected in a database were analyzed.SBTT and CE findings were recorded.A running mean for the SBTT was calculated and correlated to the diagnostic yield with a Spearman's correlation test.Subgroup analyses were performed for the various indications for the procedure.RESULTS:There was a positive correlation between the diagnostic yield and SBTT (Spearman's rho 0.58,P < 0.01).Positive correlations between diagnostic yield and SBlT were found for the indication obscure gastrointestinal bleeding (r =0.54,P < 0.01),for polyposis and carcinoid combined (r =0.56,P < 0.01) and for the other indications (r =0.90,P <0.01),but not for suspected Crohn's disease (r =-0.40).CONCLUSION:The diagnostic yield in small bowel capsule endoscopy is positively correlated with the small bowel transit time.This is true for all indications except for suspected Crohn's disease.

  20. On the dispersion relation of the transit time instability in inverted fireballs

    Energy Technology Data Exchange (ETDEWEB)

    Gruenwald, J., E-mail: jgruenwald@gmx.at [Institute of Physics, University of Graz, Universitaetsplatz 5, 8010 Graz (Austria)

    2014-08-15

    Recently discovered inverted fireballs are non-linear plasma phenomena, which are formed in hollow grid anodes with high transparency in an existing background plasma. If a sufficiently large potential is applied, accelerated electrons from the bulk start to oscillate through the grid. Experimental investigations have shown that they produce different types of plasma instabilities. One of those oscillations is a transit time instability which originates from strong electron beams that travel through the inverted fireball. This type of instability is similar to vircator reflex oscillations and produces radio frequency waves. Hence, it is suitable to convert DC signals into signals oscillating in the MHz range. This paper analyses the dispersion relation of the transit time instability for three different plasma regimes. The regimes can be divided into a collision less regime, a regime with high collisionality and one in between those former two. It is demonstrated that the plasma properties of the surrounding background plasma have a strong influence on the behavior of the instability itself.

  1. Pulse transit time variability analysis in an animal model of endotoxic shock.

    Science.gov (United States)

    Tang, Collin H H; Chan, Gregory S H; Middleton, Paul M; Cave, Grant; Harvey, Martyn; Javed, Faizan; Savkin, Andrey V; Lovell, Nigel H

    2010-01-01

    The use of non-invasively measured pulse transit time (PTT) to monitor the cardiovascular systems in critically ill patients, like sepsis, can be of significant clinical value. In this study, the potential of PTT and its variability in cardiovascular system monitoring in a mechanically ventilated and anesthetized rabbit model of endotoxic shock was assessed. Eight adult New Zealand white rabbits, which were treated with endotoxin bolus infusion, were studied. Measurements of PTT, pre-ejection period (PEP), and vascular transit time (VTT) were obtained in pre- and post-intervention stages (before and 90 minutes after the administration of endotoxin). The decrease in mean PTT (p VTT (p VTT (R(2) ≥ 0.84 with positive slope). Computation of coherence and phase shift in the ventilating frequency band (HF: 0.50 - 0.75 Hz) showed that the respiratory variation in PTT was synchronized with both PEP and VTT (coherence > 0.84 with phase shift less than one cardiac beat). These results highlighted the potential value of PTT and its respiratory variation in characterizing the pathophysioloigcal hemodynamic change in endotoxic shock.

  2. Effects of anatomical position on esophageal transit time: A biomagnetic diagnostic technique

    Institute of Scientific and Technical Information of China (English)

    Teodoro Cordova-Fraga; Modesto Sosa; Cados Wiechers; Jose Maria De la Roca-Chiapas; Alejandro Maldonado Moreles; Jesus BernaI-Alvarado; Raquel Huerta-Franco

    2008-01-01

    AIM: To study the esophageal transit time (ETT)and compare its mean value among three anatomical inclinations of the body; and to analyze the correlation of ETT to body mass index (BMI).METHODS: A biomagnetic technique was implemented to perform this study: (1) The transit time of a magnetic marker (MM) through the esophagus was measured using two fluxgate sensors placed over the chest of 14 healthy subjects; (2) the ETT was assessed in three anatomical positions (at upright,fowler,and supine positions; 90°,45° and 0°,respectively).RESULTS: ANOVA and Tuckey post-hoc tests demonstrated significant differences between ETT mean of the different positions.The ETT means were 5.2 ±1.1 s,6.1±1.5 s,and 23.6 ± 9.2 s for 90°,45° and 0°,respectively.Pearson correlation results were r = -0.716 and P < 0.001 by subjects' anatomical position,and r =-0.024 and P > 0.05 according the subject's BHI.CONCLUSION: We demonstrated that using this biomagnetic technique,it is possible to measure the ETT and the effects of the anatomical position on the ETT.

  3. On the dispersion relation of the transit time instability in inverted fireballs

    Science.gov (United States)

    Gruenwald, J.

    2014-08-01

    Recently discovered inverted fireballs are non-linear plasma phenomena, which are formed in hollow grid anodes with high transparency in an existing background plasma. If a sufficiently large potential is applied, accelerated electrons from the bulk start to oscillate through the grid. Experimental investigations have shown that they produce different types of plasma instabilities. One of those oscillations is a transit time instability which originates from strong electron beams that travel through the inverted fireball. This type of instability is similar to vircator reflex oscillations and produces radio frequency waves. Hence, it is suitable to convert DC signals into signals oscillating in the MHz range. This paper analyses the dispersion relation of the transit time instability for three different plasma regimes. The regimes can be divided into a collision less regime, a regime with high collisionality and one in between those former two. It is demonstrated that the plasma properties of the surrounding background plasma have a strong influence on the behavior of the instability itself.

  4. Transit time instabilities in an inverted fireball. II. Mode jumping and nonlinearities

    Science.gov (United States)

    Stenzel, R. L.; Gruenwald, J.; Fonda, B.; Ionita, C.; Schrittwieser, R.

    2011-01-01

    A fireball is formed inside a highly transparent spherical grid immersed in a dc discharge plasma. The ambient plasma acts as a cathode and the positively biased grid as an anode. A strong nearly current-free double layer separates the two plasmas. Electrons are accelerated into the fireball, ionize, and establish a discharge plasma with plasma potential near the grid potential. Ions are ejected from the fireball. Since electrons are lost at the same rate as ions, most electrons accelerated into the fireball just pass through it. Thus, the electron distribution contains radially counterstreaming electrons. High-frequency oscillations are excited with rf period given by the electron transit time through the fireball. Since the frequency is well below the electron plasma frequency, no eigenmodes other than a beam space-charge wave exists. The instability is an inertial transit-time instability similar to the sheath-plasma instability or the reflex vircator instability. In contrast to vircators, there is no electron reflection from a space-charge layer but counterstreaming arises from spherical convergence and divergence of electrons. While the basic instability properties have been presented in a companion paper [R. L. Stenzel et al., Phys. Plasmas 18, 012104 (2011)], the present paper focuses on observed mode jumping and nonlinear effects. The former produce frequency jumps and different potential profiles, the latter produce harmonics associated with electron bunching at large amplitudes. In situ probe measurements are presented and interpreted.

  5. Detection of Laplace-resonant three-planet systems from transit timing variations

    CERN Document Server

    Libert, A -S

    2013-01-01

    Transit timing variations (TTVs) are useful to constrain the existence of perturbing planets, especially in resonant systems where the variations are strongly enhanced. Here we focus on Laplace-resonant three-planet systems, and assume the inner planet transits the star. A dynamical study is performed for different masses of the three bodies, with a special attention to terrestrial planets. We consider a maximal time-span of ~ 100 years and discuss the shape of the inner planet TTVs curve. Using frequency analysis, we highlight the three periods related to the evolution of the system: two periods associated with the Laplace-resonant angle and the third one with the precession of the pericenters. These three periods are clearly detected in the TTVs of an inner giant planet perturbed by two terrestrial companions. Only two periods are detected for a Jupiter-Jupiter-Earth configuration (the ones associated with the giant interactions) or for three terrestrial planets (the Laplace periods). However, the latter sy...

  6. Time to move on: Modeling transcription dynamics during an embryonic transition away from maternal control.

    Science.gov (United States)

    Liu, Junbo; Xiao, Yanyu; Zhang, Tongli; Ma, Jun

    2016-07-01

    In a recent study, we investigated the regulation of hunchback (hb) transcription dynamics in Drosophila embryos. Our results suggest that shutdown of hb transcription at early nuclear cycle (nc) 14 is an event associated with the global changes taking place during the mid-blastula transition (MBT). Here we have developed a simple model of hb transcription dynamics during this transition time. With kinetic parameters estimated from our published experimental data, the model describes the dynamical processes of hb gene transcription and hb mRNA accumulation. With two steps, transcription onset upon exiting the previous mitosis followed by a sudden impact that blocks gene activation, the model recapitulates the observed dynamics of hb transcription during the nc14 interphase. The timing of gene inactivation is essential, as its alterations lead to changes in both hb transcription dynamics and hb mRNA levels. Our model provides a clear dynamical picture of hb transcription regulation as one of the many, actively regulated events concurrently taking place during the MBT. PMID:27172244

  7. Sport Transition of JPSS VIIRS Imagery for Night-time Applications

    Science.gov (United States)

    Fuell, Kevin; LeRoy, Anita; Smith, Matt; Miller, Steve; Kann, Diedre; Bernhardt, David; Reydell, Nezette; Cox, Robert

    2014-01-01

    The NASA/Short-term Prediction, Research, and Transition (SPoRT) Program and NOAA/Cooperative Institute for Research in the Atmosphere (CIRA) work within the NOAA/Joint Polar Satellite System (JPSS) Proving Ground to demonstrate the unique capabilities of the VIIRS instrument. Very similar to MODIS, the VIIRS instrument provides many high-resolution visible and infrared channels in a broad spectrum. In addition, VIIRS is equipped with a low-light sensor that is able to detect light emissions from the land and atmosphere as well as reflected sunlight by the lunar surface. This band is referred to as the Day-Night Band due to the sunlight being used at night to see cloud and topographic features just as one would typically see in day-time visible imagery. NWS forecast offices that collaborate with SPoRT and CIRA have utilized MODIS imagery in operations, but have longed for more frequent passes of polar-orbiting data. The VIIRS instrument enhances SPoRT collaborations with WFOs by providing another day and night-time pass, and at times two additional passes due to its large swath width. This means that multi-spectral, RGB imagery composites are more readily available to prepare users for their use in GOES-R era and high-resolution imagery for use in high-latitudes is more frequently able to supplement standard GOES imagery within the SPoRT Hybrid GEO-LEO product. The transition of VIIRS also introduces the new Day-Night Band capability to forecast operations. An Intensive Evaluation Period (IEP) was conducted in Summer 2013 with a group of "Front Range" NWS offices related to VIIRS night-time imagery. VIIRS single-channel imagery is able to better analyze the specific location of fire hotspots and other land features, as well as provide a more true measurement of various cloud and aerosol properties than geostationary measurements, especially at night. Viewed within the SPoRT Hybrid imagery, the VIIRS data allows forecasters to better interpret the more frequent, but

  8. Search for time-independent Lorentz violation using muon neutrino to muon antineutrino transitions in MINOS

    CERN Document Server

    Adamson, P; Aurisano, A; Barr, G; Bishai, M; Blake, A; Bock, G J; Bogert, D; Cao, S V; Carroll, T J; Castromonte, C M; Chen, R; Childress, S; Coelho, J A B; Corwin, L; Cronin-Hennessy, D; de Jong, J K; de Rijck, S; Devan, A V; Devenish, N E; Diwan, M V; Escobar, C O; Evans, J J; Falk, E; Feldman, G J; Flanagan, W; Frohne, M V; Gabrielyan, M; Gallagher, H R; Germani, S; Gomes, R A; Goodman, M C; Gouffon, P; Graf, N; Gran, R; Grzelak, K; Habig, A; Hahn, S R; Hartnell, J; Hatcher, R; Holin, A; Huang, J; Hylen, J; Irwin, G M; Isvan, Z; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Koizumi, G; Kordosky, M; Kreymer, A; Lang, K; Ling, J; Litchfield, P J; Lucas, P; Mann, W A; Marshak, M L; Mayer, N; McGivern, C; Medeiros, M M; Mehdiyev, R; Meier, J R; Messier, M D; Miller, W H; Mishra, S R; Sher, S Moed; Moore, C D; Mualem, L; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Nowak, J A; O'Connor, J; Orchanian, M; Pahlka, R B; Paley, J; Patterson, R B; Pawloski, G; Perch, A; Pfützner, M M; Phan, D D; Phan-Budd, S; Plunkett, R K; Poonthottathil, N; Qiu, X; Radovic, A; Rebel, B; Rosenfeld, C; Rubin, H A; Sail, P; Sanchez, M C; Schneps, J; Schreckenberger, A; Schreiner, P; Sharma, R; Sousa, A; Tagg, N; Talaga, R L; Thomas, J; Thomson, M A; Tian, X; Timmons, A; Todd, J; Tognini, S C; Toner, R; Torretta, D; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Weber, A; Webb, R C; White, C; Whitehead, L; Whitehead, L H; Wojcicki, S G; Zwaska, R

    2016-01-01

    Data from the MINOS experiment has been used to search for mixing between muon neutrinos and muon antineutrinos using a time-independent Lorentz-violating formalism derived from the Standard-Model Extension (SME). MINOS is uniquely capable of searching for muon neutrino-antineutrino mixing given its long baseline and ability to distinguish between neutrinos and antineutrinos on an event-by-event basis. Neutrino and antineutrino interactions were observed in the MINOS Near and Far Detectors from an exposure of 10.56$\\times10^{20}$ protons-on-target from the NuMI neutrino-optimized beam. No evidence was found for such transitions and new, highly stringent limits were placed on the SME coefficients governing them. We place the first limits on the SME parameters $(c_{L})^{TT}_{\\mu\\mu} $ and $(c_{L})^{TT}_{\\tau\\tau}$ at $-8.4\\times10^{-23} < (c_{L})^{TT}_{\\mu\\mu} < 8.0\\times10^{-23}$ and $-8.0\\times10^{-23} < (c_{L})^{TT}_{\\tau\\tau} < 8.4\\times10^{-23}$, and the world's best limits on the $\\tilde{g}^{Z...

  9. Spectral analysis of finite-time correlation matrices near equilibrium phase transitions

    Science.gov (United States)

    Vinayak; Prosen, T.; Buča, B.; Seligman, T. H.

    2014-10-01

    We study spectral densities for systems on lattices, which, at a phase transition display, power-law spatial correlations. Constructing the spatial correlation matrix we prove that its eigenvalue density shows a power law that can be derived from the spatial correlations. In practice time series are short in the sense that they are either not stationary over long time intervals or not available over long time intervals. Also we usually do not have time series for all variables available. We shall make numerical simulations on a two-dimensional Ising model with the usual Metropolis algorithm as time evolution. Using all spins on a grid with periodic boundary conditions we find a power law, that is, for large grids, compatible with the analytic result. We still find a power law even if we choose a fairly small subset of grid points at random. The exponents of the power laws will be smaller under such circumstances. For very short time series leading to singular correlation matrices we use a recently developed technique to lift the degeneracy at zero in the spectrum and find a significant signature of critical behavior even in this case as compared to high temperature results which tend to those of random matrix models.

  10. The η transition form factor from space- and time-like experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Escribano, R. [Universitat Autonoma de Barcelona, Departament de Fisica, Grup de Fisica Teorica, and Institut de Fisica d' Altes Energies (IFAE), Bellaterra, Barcelona (Spain); Masjuan, P.; Sanchez-Puertas, P. [Johannes Gutenberg-Universitaet, PRISMA Cluster of Excellence, Institut fuer Kernphysik, Mainz (Germany)

    2015-09-15

    The η transition form factor is analyzed for the first time in both space- and time-like regions at low and intermediate energies in a model-independent approach through the use of rational approximants. The η @→ e{sup +}e{sup -}γ experimental data provided by the A2 Collaboration in the very low energy region of the dielectron invariant mass distribution allows for the extraction of the most precise up-to-date slope and curvature parameters of the form factors as well as their values at zero and infinity. The impact of these new results on the mixing parameters of the η-η' system, together with the role played by renormalization dependent effects, and on the determination of the V Pγ couplings from V @→ Pγ and P → Vγ radiative decays is also discussed. (orig.)

  11. Forced bursting and transition mechanism in CO oxidation with three time scales

    Institute of Scientific and Technical Information of China (English)

    Li Xiang-Hong; Bi Qin-Sheng

    2013-01-01

    The mathematical model of CO oxidation with three time scales on platinum group metals is investigated,in which order gaps between the time scales related to external perturbation and the rates associated with different chemical reaction steps exist.Forced bursters,such as point-point type forced bursting and point-cycle type forced bursting,are presented.The bifurcation mechanism of forced bursting is novel,and the phenomenon where two different kinds of spiking states coexist in point-cycle type forced bursting has not been reported in previous work.A double-parameter bifurcation set of the fast subsystem is explored to reveal the transition mechanisms of different forced bursters with parameter variation.

  12. Promoting physiologic transition at birth: re-examining resuscitation and the timing of cord clamping.

    Science.gov (United States)

    Niermeyer, Susan; Velaphi, Sithembiso

    2013-12-01

    Delayed clamping of the umbilical cord is recommended for term and preterm infants who do not require resuscitation. However, the approach to the newly born infant with signs of fetal compromise, prematurity and extremely low birthweight, or prolonged apnea is less clear. Human and experimental animal data show that delaying the clamping of the umbilical cord until after the onset of respirations promotes cardiovascular stability in the minutes immediately after birth. Rather than regarding delayed cord clamping as a fixed time period before resuscitation begins, a more physiologic concept of transition at birth should encompass the relative timing of onset of respirations and cord occlusion. Further research to explore the potential benefits of resuscitation with the cord intact is needed. PMID:24055300

  13. Exploring sensitive dependence and transitivity to optimize travel time in chaotic systems

    International Nuclear Information System (INIS)

    Transitivity and sensitive dependence on initial conditions are the main characteristics of chaotic behavior. The latter one can be exploited so that small controlled perturbations in system parameters may imply a faster transfer in time from a desired start point to a neighborhood of a desired final state. In this study three targeting approaches are evaluated: The first one uses a geometric approach to find the proper perturbation which allows a faster transfer between two desired points; The second, an evolutionary algorithm called GEO (Generalized External Optimization), is adapted to search for optimized orbits; The third one, uses successive perturbations along the path in order to direct the orbits to the final desired point in a short time interval. These three methods are evaluated regarding performance and implementation complexity

  14. THE NEW COMPUTERIZED TRANSIT SYSTEM AND E-CUSTOMS INFLUENCE ON SAVINGS IN TRANSIT TIME AND COSTS

    OpenAIRE

    Aleksandar Erceg

    2013-01-01

    E-customs is dramatically changing the role of customs offices and international forwarders. E-customs comprises from different activit ies which are used for a safe exchange of goods, services and information using computers and modern information and communicat ion technologies. New e-Customs system is based on new customs procedures and tax system as well as new commerce and statistics regulation in Croatia. The New Computerized Transit System (NCTS) is one of the first e-Customs tools whi...

  15. Factors controlling inter-catchment variation of mean transit time with consideration of temporal variability

    Science.gov (United States)

    Ma, Wenchao; Yamanaka, Tsutomu

    2016-03-01

    The catchment transit time, a lumped descriptor reflecting both time scale and spatial structure of catchment hydrology can provide useful insights into chemical/nuclear pollution risks within a catchment. Despite its importance, factors controlling spatial variation of mean transit time (MTT) are not yet well understood. In this study, we estimated time-variant MTTs for about ten years (2003-2012) in five mesoscale sub-catchments of the Fuji River catchment, central Japan, to establish the factors controlling their inter-catchment variation with consideration of temporal variability. For this purpose, we employed a lumped hydrological model that was calibrated and validated by hydrometric and isotopic tracer observations. Temporal variation patterns of estimated MTT were similar in all sub-catchments, but with differing amplitudes. Inter-catchment variation of MTT was greater in dry periods than wet periods, suggesting spatial variation of MTT is controlled by water 'stock' rather than by 'flow'. Although the long-term average MTT (LAMTT) in each catchment was correlated with mean slope, coverage of forest (or conversely, other land use types), coverage of sand-shale conglomerate, and groundwater storage, the multiple linear regression revealed that inter-catchment variation of LAMTT is principally controlled by the amount of groundwater storage. This is smaller in mountainous areas covered mostly by forests and greater in plain areas with less forest coverage and smaller slope. This study highlights the topographic control of MTT via groundwater storage, which might be a more important factor in mesoscale catchments, including both mountains and plains, rather than in smaller catchments dominated by mountainous topography.

  16. Signal Transceiver Transit Times and Propagation Delay Corrections for Ranging and Georeferencing Applications

    Directory of Open Access Journals (Sweden)

    P. Kaufmann

    2012-01-01

    Full Text Available The accuracy of ranging measurements depends critically on the knowledge of time delays undergone by signals when retransmitted by a remote transponder and due to propagation effects. A new method determines these delays for every single pulsed signal transmission. It utilizes four ground-based reference stations, synchronized in time and installed at well-known geodesic coordinates and a repeater in space, carried by a satellite, balloon, aircraft, and so forth. Signal transmitted by one of the reference bases is retransmitted by the transponder, received back by the four bases, producing four ranging measurements which are processed to determine uniquely the time delays undergone in every retransmission process. A minimization function is derived comparing repeater’s positions referred to at least two groups of three reference bases, providing the signal transit time at the repeater and propagation delays, providing the correct repeater position. The method is applicable to the transponder platform positioning and navigation, time synchronization of remote clocks, and location of targets. The algorithm has been demonstrated by simulations adopting a practical example with the transponder carried by an aircraft moving over bases on the ground.

  17. Lactose malabsorption in Greek adults: correlation of small bowel transit time with the severity of lactose intolerance.

    OpenAIRE

    Ladas, S.; Papanikos, J; Arapakis, G

    1982-01-01

    Using breath hydrogen analysis after 139 mmol (50 g) oral lactose load, we investigated the prevalence of lactose malabsorption in 200 Greek adults and examined the relationship between symptoms and small bowel transit time. One hundred and fifty subjects had increased breath hydrogen concentrations (greater than 20 ppm) after the lactose load. In these individuals peak breath hydrogen concentration was inversely related to small bowel transit time (r = 0.63, 6 = 6.854, p less than 0.001) and...

  18. STUDY OF THE BEHAVIOR MODELS BASED ON PROBABILITY AND TIME BY USING MARKOV PROCESS AND TRANSITION MATRIX.

    OpenAIRE

    Sumangala Patil; P.Nagaraju; Somashekar Deasi

    2012-01-01

    This paper suggests an approach to software system architecture specification based on behavior models. The behavior of the system is defined as an event occurring probability and time. The behavior ofthe system over a time of stationary Markov process is completely characterized by the one step transition matrix, the matrix of instantaneous transition rates. Given the element of the appropriative matrix, it is possible to calculate probability of event of the process.

  19. Dynamic contrast optical coherence tomography: quantitative measurement of microvascular transit-time distributions in vivo (Conference Presentation)

    Science.gov (United States)

    Merkle, Conrad W.; Srinivasan, Vivek J.

    2016-03-01

    Transit time is a fundamental microcirculatory parameter that is critical in determining oxygen delivery from capillaries to surrounding tissue. Recently, it was demonstrated theoretically that capillary transit-time heterogeneity potentially leads to non-uniform oxygen extraction in micro-domains. However, in spite of its importance, capillary transit-time distribution has been challenging to quantify comprehensively and efficiently at the microscopic level. Here, we introduce a method, called Dynamic Contrast Optical Coherence Tomography (DyC-OCT), based on dynamic cross-sectional OCT imaging of the kinetics of an intravascular tracer during its passage through the field-of-view. DyC-OCT is used to quantitatively measure the transit-time distribution in microvascular networks in cross-section at the single-capillary level. Transit-time metrics are derived from analysis of the temporal characteristics of the dynamic scattering signal, related to tracer concentration, using indicator-dilution theory. Since DyC-OCT does not require calibration of the optical focus, quantitative accuracy is achieved even deep in highly scattering brain tissue where the focal spot degrades. After direct validation of DyC-OCT against the dilution curves measured using a fluorescent plasma label in the surface pial vessels of a mouse brain, imaged through a thinned-skull, glass coverslip-reinforced cranial window, the laminar transit-time distribution was investigated in microvasculature across the entire depth of the mouse somatosensory cortex. Laminar trends were identified, with the earliest transit times in the middle cortical layers, and the lowest heterogeneity in cortical layer 4. The new DyC-OCT technique affords a novel perspective of microvascular networks, with the unique capability of performing simultaneous measurements of transit-time distributions across cortical laminae.

  20. The scintigraphic determination of small intestinal transit time in patients with irritable bowel syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Marano, A.R.; Caride, V.J.; Shah, R.V.; Prokop, E.K.; Troncale, F.J.; McCallum, R.W.

    1984-01-01

    Diffuse disturbance in gastrointestinal motility may be present in patients with irritable bowel syndrome (IBS). To further investigate small intestinal motility in IBS patients small intestinal transit time (SITT) was determined and related to the symptom status. 11 female patients with IBS (mean age 29 years) were divided into those whose predominate symptom was diarrhea (N=6), and those with only constipation (N=5). All subjects ingested an isosmotic solution of lactulose (10 gm in 150cc of water) labeled with 99m-Tc-DTPA (Sn). The patient was studied supine under a 25 inch gamma camera with data collected at 1 frame per minute for 180 minutes or until activity appeared in the ascending colon. Regions of interest were selected over the cecum and ascending colon. The time of first appearance of radioactivity in the region of the cecum was taken as the small intestinal transit time. SITT in the 5 normal females was 98.7 +- 13 min (mean +- SEM). SITT in the IBS patients with diarrhea, 67.3 +- 7 min was significantly faster (p< 0.08). SITT in the constipated IBS patients, 126 +- 12 min, was slower than normals and significantly different from diarrhea patients (p< 0.001). These studies show that IBS patients with diarrhea have significantly faster SITT than normals while constipated IBS patients have significantly slower SITT than the diarrhea subgroup. Further, this study emphasizes the need to study the various symptomatic subgroups of IBs patients independently and indicates a possible role for abnormal SITT in the pathogenesis of IBS.

  1. Life time of the HFS transition in Li-like {sup 209}Bi{sup 80+}

    Energy Technology Data Exchange (ETDEWEB)

    Geppert, C.; Noertershaeuser, W. [Institut fuer Kernchemie, Uni Mainz (Germany); GSI, Darmstadt (Germany); Hannen, V.; Joehren, R.; Ortjohann, H.W.; Vollbrecht, J.; Weinheimer, C. [Institut fuer Kernphysik, Uni Muenster (Germany); Kuehl, T. [Institut fuer Kernchemie, Uni Mainz (Germany); GSI, Darmstadt (Germany); Helmholtz Institut Jena (Germany); S' anchez, R.; Winters, D. [GSI, Darmstadt (Germany); Stoehlker, T. [Institut fuer Kernchemie, Uni Mainz (Germany); GSI, Darmstadt (Germany); Helmholtz Institut Jena (Germany); Uni Jena (Germany)

    2014-07-01

    Measuring the hyperfine splitting of heavy, highly charged ions enables tests of QED in strong fields. HFS calculations have a relative uncertainty of more than 10{sup -3} due to the distribution of the magnetic moment (Bohr-Weisskopf-Effekt). With an appropriate comparison of H- and Li-like ions this nuclear structure contribution can be suppressed. Bismuth is a suitable element for these studies, as the HFS splitting for both configurations are in a wavelength range suitable for laser spectroscopy. For this purpose the two ion species were stored in the Experimental Storage Ring at GSI at a velocity of β = 0.71. To efficiently collect the forward emitted photons a specially developed movable detector system was used. Thereby the HFS of Li-like {sup 209}Bi{sup 80+} was successfully measured for the first time. Besides the determination of the transition energy it was possible to extract the lifetime of the transition out of the collected data. The corresponding analysis and the results are presented on this poster.

  2. VIDEO CAPSULE ENDOSCOPY: A TOOL FOR THE ASSESSMENT OF SMALL BOWEL TRANSIT TIME

    Directory of Open Access Journals (Sweden)

    Reza A Hejazi

    2016-02-01

    Full Text Available Purpose: Video capsule endoscopy (VCE is a procedure that uses a wireless camera to take pictures of the gastrointestinal tract. A wireless motility capsule (WMC of a similar size has been developed, which measures pH, pressure, and temperature, and can be used to assess regional and total gastrointestinal transit times. VCE could also potentially be used as a tool for measuring small bowel transit time (SBTT.Methods: This study was designed to obtain SBTT from VCE and compare it with historical data generated by WMC. Gastric transit time (GTT was also measured. Patients were included if the indication for VCE was either iron deficiency anemia (IDA or overt obscure GI bleed (OOGIB and they did not have any known motility disorder. Results from VCE were also compared in diabetic versus non-diabetic patients. Results: There were a total of 147 VCE studies performed, including 42 for OOGIB and 105 for IDA. Median GTT and SBTT were 0.3 and 3.6 hours, respectively. The overall median GTT and SBTT were 0.3 and 3.6 hours, respectively, in the IDA group compared with 0.3 and 3.4 hours in the OOGIB group. When compared with WMC, the GTT and SBTT were significantly faster in both groups (GTT: 3.6 hours and SBTT: 4.6 hours. The median GTT and SBTT were not significantly different in diabetics versus non-diabetics: (GTT: 17.5 vs. 18.0 minutes (P=0.86 and SBTT: 3.9 hours (237 minutes vs. 3.8 hours (230 minutes, respectively (P=0.90.Conclusion: SBTT as measured using VCE is not significantly different in OOGIB compared with IDA. Both GTT and SBTT are significantly faster as assessed by VCE, which is initiated in the fasting state, compared with WMC measurement, which is initiated after a standard meal. In summary, VCE could potentially be used for measuring SBTT in the fasting state.

  3. Noninvasive measurement of cerebrospinal fluid flow using an ultrasonic transit time flow sensor: a preliminary study.

    Science.gov (United States)

    Pennell, Thomas; Yi, Juneyoung L; Kaufman, Bruce A; Krishnamurthy, Satish

    2016-03-01

    OBJECT Mechanical failure-which is the primary cause of CSF shunt malfunction-is not readily diagnosed, and the specific reasons for mechanical failure are not easily discerned. Prior attempts to measure CSF flow noninvasively have lacked the ability to either quantitatively or qualitatively obtain data. To address these needs, this preliminary study evaluates an ultrasonic transit time flow sensor in pediatric and adult patients with external ventricular drains (EVDs). One goal was to confirm the stated accuracy of the sensor in a clinical setting. A second goal was to observe the sensor's capability to record real-time continuous CSF flow. The final goal was to observe recordings during instances of flow blockage or lack of flow in order to determine the sensor's ability to identify these changes. METHODS A total of 5 pediatric and 11 adult patients who had received EVDs for the treatment of hydrocephalus were studied in a hospital setting. The primary EVD was connected to a secondary study EVD that contained a fluid-filled pressure transducer and an in-line transit time flow sensor. Comparisons were made between the weight of the drainage bag and the flow measured via the sensor in order to confirm its accuracy. Data from the pressure transducer and the flow sensor were recorded continuously at 100 Hz for a period of 24 hours by a data acquisition system, while the hourly CSF flow into the drip chamber was recorded manually. Changes in the patient's neurological status and their time points were noted. RESULTS The flow sensor demonstrated a proven accuracy of ± 15% or ± 2 ml/hr. The flow sensor allowed real-time continuous flow waveform data recordings. Dynamic analysis of CSF flow waveforms allowed the calculation of the pressure-volume index. Lastly, the sensor was able to diagnose a blocked catheter and distinguish between the blockage and lack of flow. CONCLUSIONS The Transonic flow sensor accurately measures CSF output within ± 15% or ± 2 ml

  4. Noninvasive measurement of cerebrospinal fluid flow using an ultrasonic transit time flow sensor: a preliminary study.

    Science.gov (United States)

    Pennell, Thomas; Yi, Juneyoung L; Kaufman, Bruce A; Krishnamurthy, Satish

    2016-03-01

    OBJECT Mechanical failure-which is the primary cause of CSF shunt malfunction-is not readily diagnosed, and the specific reasons for mechanical failure are not easily discerned. Prior attempts to measure CSF flow noninvasively have lacked the ability to either quantitatively or qualitatively obtain data. To address these needs, this preliminary study evaluates an ultrasonic transit time flow sensor in pediatric and adult patients with external ventricular drains (EVDs). One goal was to confirm the stated accuracy of the sensor in a clinical setting. A second goal was to observe the sensor's capability to record real-time continuous CSF flow. The final goal was to observe recordings during instances of flow blockage or lack of flow in order to determine the sensor's ability to identify these changes. METHODS A total of 5 pediatric and 11 adult patients who had received EVDs for the treatment of hydrocephalus were studied in a hospital setting. The primary EVD was connected to a secondary study EVD that contained a fluid-filled pressure transducer and an in-line transit time flow sensor. Comparisons were made between the weight of the drainage bag and the flow measured via the sensor in order to confirm its accuracy. Data from the pressure transducer and the flow sensor were recorded continuously at 100 Hz for a period of 24 hours by a data acquisition system, while the hourly CSF flow into the drip chamber was recorded manually. Changes in the patient's neurological status and their time points were noted. RESULTS The flow sensor demonstrated a proven accuracy of ± 15% or ± 2 ml/hr. The flow sensor allowed real-time continuous flow waveform data recordings. Dynamic analysis of CSF flow waveforms allowed the calculation of the pressure-volume index. Lastly, the sensor was able to diagnose a blocked catheter and distinguish between the blockage and lack of flow. CONCLUSIONS The Transonic flow sensor accurately measures CSF output within ± 15% or ± 2 ml

  5. Life Course Transitions and Housework: Marriage, Parenthood, and Time on Housework

    Science.gov (United States)

    Baxter, Janeen; Hewitt, Belinda; Haynes, Michele

    2008-01-01

    We examine the effects of transitions in marital and parenthood status on 1,091 men's and women's housework hours using two waves of data from an Australian panel survey titled Negotiating the Life Course. We examine transitions between cohabitation and marriage, and from cohabitation or marriage to separation, as well as transitions to first and…

  6. A transit timing analysis of nine RISE light curves of the exoplanet system TrES-3

    CERN Document Server

    Gibson, N P; Skillen, I; Simpson, E K; Barros, S; Joshi, Y C; Todd, I; Benn, C; Christian, D; Hrudková, M; Keenan, F P; Steele, I A

    2009-01-01

    We present nine newly observed transits of TrES-3, taken as part of a transit timing program using the RISE instrument on the Liverpool Telescope. A Markov-Chain Monte-Carlo analysis was used to determine the planet-star radius ratio and inclination of the system, which were found to be Rp/Rstar=0.1664^{+0.0011}_{-0.0018} and i = 81.73^{+0.13}_{-0.04} respectively, consistent with previous results. The central transit times and uncertainties were also calculated, using a residual-permutation algorithm as an independent check on the errors. A re-analysis of eight previously published TrES-3 light curves was conducted to determine the transit times and uncertainties using consistent techniques. Whilst the transit times were not found to be in agreement with a linear ephemeris, giving chi^2 = 35.07 for 15 degrees of freedom, we interpret this to be the result of systematics in the light curves rather than a real transit timing variation. This is because the light curves that show the largest deviation from a con...

  7. The City: Spaces, Times and Subjects in the Global Transition (edited by Niccolò Cuppini

    Directory of Open Access Journals (Sweden)

    Niccolò Cuppini

    2015-12-01

    Full Text Available Within the entering in the global era, the city is come back again as a strategic architrave of the world's infrastructure – while the State, the historical figure through which Modernity was organized, has been declared in crisis long time ago. Despite the broad spectrum of urban reflections, there still is a deep lack of political theory of the city. The globalization of the city – within the pathway of the planetary urbanization – is the object of the article, that elaborates on a twofold level: on one hand, a genealogical trace of that process is proposed – articulating it by distilling urban political thought from different authors and historical episodes; on the other hand, the article suggests a theoretical and methodological horizon through which to grasp the contemporary global transitions, labelled as “seeing like a city”.

  8. Sensitivity bias in the mass-radius distribution from Transit Timing Variations and Radial Velocity measurements

    CERN Document Server

    Steffen, Jason H

    2015-01-01

    Motivated by recent discussions, both in private and in the literature, we use a Monte Carlo simulation of planetary systems to investigate sources of bias in determining the mass-radius distribution of exoplanets for the two primary techniques used to measure planetary masses---Radial Velocities (RVs) and Transit Timing Variations (TTVs). We assert that mass measurements derived from these two methods are comparably reliable---as the physics underlying their respective signals is well understood. Nevertheless, their sensitivity to planet mass varies with the properties of the planets themselves. We find that for a given planet size, the RV method tends to find planets with higher mass while the sensitivity of TTVs is more uniform. This ``sensitivity bias'' implies that a complete census of TTV systems is likely to yield a more robust estimate of the mass-radius distribution provided there are not important physical differences between planets near and far from mean-motion resonance. We discuss differences in...

  9. Transition among synchronous schemes in coupled nonidentical multiple time delay systems

    Energy Technology Data Exchange (ETDEWEB)

    Thang Manh Hoang [Department of Electronics and Informatics, Faculty of Electronics and Telecommunications, Hanoi University of Technology, 1 Dai Co Viet, Hanoi (Viet Nam)], E-mail: hmt@mail.hut.edu.vn

    2009-10-30

    We present the transition among possible synchronous schemes in coupled nonidentical multiple time delay systems, i.e., lag, projective-lag, complete, anticipating and projective-anticipating synchronization. The number of nonlinear transforms in the master's equation can be different from that in slave's, and nonlinear transforms can be in various forms. The driving signal is the sum of nonlinearly transformed components of delayed state variable. Moreover, the equation representing for driving signal is constructed exactly so that the difference between the master's and slave's structures is complemented. The sufficient condition for synchronization is considered by the Krasovskii-Lyapunov theory. The specific examples will demonstrate and verify the effectiveness of the proposed models.

  10. Time-Resolved Emittance Characterization of an Induction Linac Beam using Optical Transition Radiation

    CERN Document Server

    Le Sage, G P

    2002-01-01

    An induction linac is used by Lawrence Livermore National Laboratory to perform radiographic testing at the Flash X-ray Radiography facility. Emittance characterization is important since x-ray spot size impacts the resolution of shadow-graphs. Due to the long pulse length, high current, and beam energy, emittance measurement using Optical Transition Radiation is an attractive alternative for reasons that will be described in the text. The utility of OTR-based emittance measurement has been well demonstrated for both RF and induction linacs. We describe the time-resolved emittance characterization of an induction linac electron beam. We have refined the optical collection system for the induction linac application, and have demonstrated a new technique for probing the divergence of a subset of the beam profile. The experimental apparatus, data reduction, and conclusions will be presented. Additionally, a new scheme for characterizing the correlation between beam divergence and spatial coordinates within the b...

  11. Flow acoustics modelling and implications for ultrasonic flow measurement based on the transit-time method.

    Science.gov (United States)

    Willatzen, M

    2004-05-01

    A comparison between three mathematical models frequently used in flow acoustics is presented and discussed with respect to ultrasonic flow-meter performance based on the transit-time method. The flow-meter spoolpiece geometry is assumed to be a cylindrical pipe. Semi-analytical calculations employing the Frobenius power series expansion method are shown for the cases of a constant-, linear-, parabolic-, and cubic-flow profiles although the Frobenius method presented can be applied to any smooth flow profile. It is shown that the so-called deviation of measurement, often used as a measure of the flow-meter accuracy, is strongly dependent on the acoustic mode excited and the flow profile. Furthermore, differences with respect to deviation of measurement results exist among the three mathematical models analyzed. PMID:15110538

  12. Time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. (Argonne National Lab., IL (United States)); Wilke, M.D. (Los Alamos National Lab., NM (United States))

    1992-01-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.

  13. Time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. [Argonne National Lab., IL (United States); Wilke, M.D. [Los Alamos National Lab., NM (United States)

    1992-09-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.

  14. Further time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. (Argonne National Lab., IL (United States). Advanced Photon Source Accelerator Systems Div.); Wilke, M.D. (Los Alamos National Lab., NM (United States))

    1992-01-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 [mu]s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.

  15. Further time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. [Argonne National Lab., IL (United States). Advanced Photon Source Accelerator Systems Div.; Wilke, M.D. [Los Alamos National Lab., NM (United States)

    1992-12-31

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.

  16. Losartan renography for the detection of renal artery stenosis: comparison with captopril renography and evaluation of dose and timing

    Energy Technology Data Exchange (ETDEWEB)

    Guenay, Emel Ceylan; Erguen, Eser Lay; Salanci, Bilge Volkan; Ugur, Oemer; Caner, Biray [Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara (Turkey); Oeztuerk, M. Halil; Hekimoglu, Baki [Social Security Hospital Clinic of Radiology, Ankara (Turkey); Altun, Buelent [Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara (Turkey); Cil, Barbaros [Hacettepe University Faculty of Medicine, Department of Radiology, Ankara (Turkey)

    2005-09-01

    Radionuclide renography with angiotensin converting enzyme (ACE) inhibition plays an important role in the diagnosis of haemodynamically significant renal artery stenosis. Angiotensin receptor antagonists inhibit the renin angiotensin system at different levels from ACE inhibitors by selectively blocking the binding of angiotensin II to AT1 receptors. The AT1 angiotensin receptor antagonist losartan has recently been used clinically in the treatment of hypertension. However, the available data on the use of losartan with renography for the detection of renovascular hypertension are limited and contradictory. The purpose of this prospective study was to compare the effectiveness of losartan renography and captopril scintigraphy in revealing renal artery stenosis. A total of 61 renal units in 32 patients with hypertension were studied in two groups based on the losartan dosage (50 mg in group A and 100 mg in group B). Group A consisted of 17 patients, in whom 19 renal units had angiographically proven renal artery stenosis ({>=}50%). In group B, there were 15 patients, in whom 20 renal arteries were stenotic. All of the patients underwent three renographies (baseline, captopril renography and early losartan renography). Early losartan renography was performed at 1 h after oral losartan administration in both groups. In group B, seven patients underwent additional losartan renography (late losartan) performed 3 h after oral losartan administration; these patients composed group B1. The sensitivities of captopril and losartan studies were 63.2% and 42% in group A, 65% and 65% in group B and 55.6% and 66.6% in group B1, respectively. From our preliminary results, we conclude that losartan is not superior to captopril renography for the detection of haemodynamically significant renal artery stenosis. However, a high dose (100 mg) of losartan provided higher sensitivity than the lower dose (50 mg). Late losartan scintigraphy provided similar diagnostic efficacy to early

  17. Pathways and transit time of meltwater in the englacial drainage system of Rabots Glacier, Kebnekaise, Sweden

    Science.gov (United States)

    Coch, Caroline; Clason, Caroline; Rosqvist, Gunhild; Jarsjö, Jerker; Brugger, Keith

    2014-05-01

    Following the crash of a Norwegian Hercules plane in the Kebnekaise mountain range in March 2012, a field campaign was initiated in order to assess the fate of the hydrocarbon pollution in the glacial system. Monitoring of pollution was conducted in the snow pack of Rabots glacier, as well as in the proglacial stream, and the preferential pathways for transport of pollutants were assessed. Since it is likely that soluble components of the aircraft fuel are transported within the glacial meltwater, our study focuses on constraining the likely transit time and dispersion of these components. The hydrologic configuration of Rabots glacier was thus studied during the 2013 ablation season by means of dye tracing experiments and discharge monitoring in the proglacial stream. The analyses of the dye return curves and stream monitoring suggest different hydrological configurations on the north and south side of the glacier, perhaps influenced by shading and the ice thermal structure. The system on the north side seems to be distributed, with extensive interaction of meltwater with the bed, as typified in the turbid proglacial outlet. The distinct peaks of the return curves on the south side indicate efficient transport, perhaps largely through englacial channels, given the relatively clear nature of the proglacial outlet. The evaluation of transit speed along a longitudinal profile contributed to the understanding of drainage efficiency with distance upglacier. The higher up the injection location on the glacier, the more distributed and less efficient the system. The seasonal evolution of efficiency was also assessed, showing an increase inefficiency with time. Furthermore, we hypothesize a disconnect in the glacial hydrological systems on the north and south side of the glacier. Pollution that is transported with the meltwater down from the crash site on the southern side most likely does not reach the drainage system on the northern side. Besides revealing potential

  18. Arterial Ageing

    OpenAIRE

    Lee, Seung-Jun; Park, Sung-Ha

    2013-01-01

    Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiabl...

  19. Empirical Assessment on Factors Affecting Travel Time of Bus Rapid Transit

    Directory of Open Access Journals (Sweden)

    Fergyanto E Gunawan

    2015-02-01

    Full Text Available Since the beginning of the century, many cities around the world adopt the bus rapid transit (BRT system to fulfill their need of mass transportation system. The system features with platform-level boarding, bus lanes in the central verge of the road, off-vehicle fare collection, and physically protected busway. So far, these criteria are considered to be the most important aspects with respect to the BRT performance. In this research, we intend to study to what extent the BRT performance may be affected by the interference of the mixed traffic during the BRT operation. We adopt an empirical approach by observing the phenomenon unfolding in the eleven TransJakarta BRT corridors. The TransJakarta BRT operates in the city of Jakarta, the capital of the Republic of Indonesia. We record the travel time data from station to station for the case where the TransJakarta bus can travel smoothly and the case where the traveling bus is interfered with the mixed traffic. For the cases, we evaluate the travel time variation. As the results, we found that the Corridor 1 of TransJakarta BRT has the best performance in term of the travel time variation. For the two directions, the corridor has the mean travel time of 34 min, the standard deviation of 3 min, and the travel time variation of 8%. On this corridor, the mixed-traffic interference is relatively negligible. On the Corridor 7, the two-direction travel times have the mean of 45 min, the standard deviation of 8 min, and the travel time variation of 16%. On the Corridor 9, the twodirection travel times have the mean of 1 hr and 25 min, the standard deviation of 11 min, and the travel time variation of 14%. On the last two corridors, the busways are heavily interfered by the mixed traffic; thus, the end-to-end travel times are significantly uncertain although only very few road segments are interfered. The research leads us to a conclusion that the interference, although only occurs on a road segment, may

  20. Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study

    Institute of Scientific and Technical Information of China (English)

    Eva Niv; Ido Bogner; Olga Barkay; Zamir Halpern; Elisabeth Mahajna; Roman Depsames; Yael Kopelman; Zvi Fireman

    2008-01-01

    AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology.METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies,50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B).Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine.RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 rain vs 28 min, with no statistical significance).SB transit time was similar for both groups (all P > 0.05).Total transit time was almost identical in both groups.The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37).Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05).CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time.It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate.Erythromycin does not adversely affect image quality.We consider the routine use of oral erythromycin preparation as being unjustified,although it might be considered in patients with known prolonged gastric emptying time.

  1. Time-resolved four-wave-mixing spectroscopy for inner-valence transitions

    CERN Document Server

    Ding, Thomas; Kaldun, Andreas; Blättermann, Alexander; Meyer, Kristina; Stooß, Veit; Rebholz, Marc; Birk, Paul; Hartmann, Maximilian; Brown, Andrew; Van Der Hart, Hugo; Pfeifer, Thomas

    2015-01-01

    Non-collinear four-wave mixing (FWM) techniques at near-infrared (NIR), visible, and ultraviolet frequencies have been widely used to map vibrational and electronic couplings, typically in complex molecules. However, correlations between spatially localized inner-valence transitions among different sites of a molecule in the extreme ultraviolet (XUV) spectral range have not been observed yet. As an experimental step towards this goal we perform time-resolved FWM spectroscopy with femtosecond NIR and attosecond XUV pulses. The first two pulses (XUV-NIR) coincide in time and act as coherent excitation fields, while the third pulse (NIR) acts as a probe. As a first application we show how coupling dynamics between odd- and even-parity inner-valence excited states of neon can be revealed using a two-dimensional spectral representation. Experimentally obtained results are found to be in good agreement with ab initio time-dependent R-matrix calculations providing the full description of multi-electron interactions,...

  2. Observing in space and time the ephemeral nucleation of liquid-to-crystal phase transitions.

    Science.gov (United States)

    Yoo, Byung-Kuk; Kwon, Oh-Hoon; Liu, Haihua; Tang, Jau; Zewail, Ahmed H

    2015-01-01

    The phase transition of crystalline ordering is a general phenomenon, but its evolution in space and time requires microscopic probes for visualization. Here we report direct imaging of the transformation of amorphous titanium dioxide nanofilm, from the liquid state, passing through the nucleation step and finally to the ordered crystal phase. Single-pulse transient diffraction profiles at different times provide the structural transformation and the specific degree of crystallinity (η) in the evolution process. It is found that the temporal behaviour of η exhibits unique 'two-step' dynamics, with a robust 'plateau' that extends over a microsecond; the rate constants vary by two orders of magnitude. Such behaviour reflects the presence of intermediate structure(s) that are the precursor of the ordered crystal state. Theoretically, we extend the well-known Johnson-Mehl-Avrami-Kolmogorov equation, which describes the isothermal process with a stretched-exponential function, but here over the range of times covering the melt-to-crystal transformation.

  3. Observing in space and time the ephemeral nucleation of liquid-to-crystal phase transitions

    Science.gov (United States)

    Yoo, Byung-Kuk; Kwon, Oh-Hoon; Liu, Haihua; Tang, Jau; Zewail, Ahmed H.

    2015-10-01

    The phase transition of crystalline ordering is a general phenomenon, but its evolution in space and time requires microscopic probes for visualization. Here we report direct imaging of the transformation of amorphous titanium dioxide nanofilm, from the liquid state, passing through the nucleation step and finally to the ordered crystal phase. Single-pulse transient diffraction profiles at different times provide the structural transformation and the specific degree of crystallinity (η) in the evolution process. It is found that the temporal behaviour of η exhibits unique `two-step' dynamics, with a robust `plateau' that extends over a microsecond; the rate constants vary by two orders of magnitude. Such behaviour reflects the presence of intermediate structure(s) that are the precursor of the ordered crystal state. Theoretically, we extend the well-known Johnson-Mehl-Avrami-Kolmogorov equation, which describes the isothermal process with a stretched-exponential function, but here over the range of times covering the melt-to-crystal transformation.

  4. Inflationary spectra from near $\\Omega$-deformed space-time transition point in Loop Quantum Cosmology

    CERN Document Server

    Chen, Long

    2016-01-01

    Anomaly-free perturbations of loop quantum cosmology with holonomy corrections reveal a $\\Omega$ -deformed space-time structure, $\\Omega:=1-2\\rho/\\rho_c$, where $\\Omega0$ means a Lorentz-like space. It would be reasonable to give the initial value at the space-time transition point, $\\rho=\\rho_c/2$, but we find it is impossible to define a Minkowski-like vacuum even for large $k$-modes at that time. However if we loose the condition and give the initial value near after $\\Omega=0$, e.g. $\\Omega\\simeq 0.2$, the vacuum state can be well defined and furthermore the slow roll approximation also works well in that region. Both scalar and tensor spectra are considered in the framework of loop quantum cosmology with holonomy corrections. We find that if the energy density is not too small compared with $\\rho_c/2$ when the considered $k$-mode crossing the horizon, effective theory can give a much smaller scalar power spectrum than classical theory and the spectrum of tensor perturbations could blue shift. But when co...

  5. Spin time-relaxation within strongly coupled paramagnetic systems exhibiting paramagnetic-ferrimagnetic transitions

    CERN Document Server

    Chahid, M

    2000-01-01

    The purpose of the present work is a quantitative study of the spin time relaxation within superweak ferrimagnetic materials exhibiting a paramagnetic-ferrimagnetic transition, when the temperature is changed from an initial value T sub i to a final one T sub f very close to the critical temperature T sub c. From a magnetic point of view, the material under investigation is considered to be made of two strongly coupled paramagnetic sublattices of respective moments phi (cursive,open) Greek and psi. Calculations are made within a Landau mean-field theory, whose free energy involves, in addition to quadratic and quartic terms in both moments phi (cursive,open) Greek and psi, a lowest-order coupling - Cphi (cursive,open) Greek psi, where C<0 stands for the coupling constant measuring the interaction between the two sublattices. We first determine the time dependence of the shifts of the order parameters delta phi (cursive,open) Greek and delta psi from the equilibrium state. We find that this time dependence ...

  6. CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture

    DEFF Research Database (Denmark)

    Waldsee, Roya; Eftekhari, Sajedeh; Ahnstedt, Hilda;

    2014-01-01

    MKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes. METHODS: Rat basilar arteries were cultured in serum-free medium for 0, 3, 6 or 24 hours in the presence....... RESULTS: Western blot evaluation showed that organ culture induced a significant increase in phosphorylated ERK1/2 at 3, 6 and 24 hours, while CaMKII was found to be already activated in fresh non-incubated arteries and to decrease with incubation time. The addition of U0126 or KN93 decreased levels...... organ culture. This inflammatory marker was reduced by both of the two different protein kinase inhibitors. CONCLUSIONS: The novel findings of the present study are that the cross-talk between the two protein kinases and the inhibition of CaMKII or MEK1/2 in a time-dependent manner attenuates...

  7. Automatic generation of time resolved motion vector fields of coronary arteries and 4D surface extraction using rotational x-ray angiography

    Science.gov (United States)

    Jandt, Uwe; Schäfer, Dirk; Grass, Michael; Rasche, Volker

    2009-01-01

    Rotational coronary angiography provides a multitude of x-ray projections of the contrast agent enhanced coronary arteries along a given trajectory with parallel ECG recording. These data can be used to derive motion information of the coronary arteries including vessel displacement and pulsation. In this paper, a fully automated algorithm to generate 4D motion vector fields for coronary arteries from multi-phase 3D centerline data is presented. The algorithm computes similarity measures of centerline segments at different cardiac phases and defines corresponding centerline segments as those with highest similarity. In order to achieve an excellent matching accuracy, an increasing number of bifurcations is included as reference points in an iterative manner. Based on the motion data, time-dependent vessel surface extraction is performed on the projections without the need of prior reconstruction. The algorithm accuracy is evaluated quantitatively on phantom data. The magnitude of longitudinal errors (parallel to the centerline) reaches approx. 0.50 mm and is thus more than twice as large as the transversal 3D extraction errors of the underlying multi-phase 3D centerline data. It is shown that the algorithm can extract asymmetric stenoses accurately. The feasibility on clinical data is demonstrated on five different cases. The ability of the algorithm to extract time-dependent surface data, e.g. for quantification of pulsating stenosis is demonstrated.

  8. Automatic generation of time resolved motion vector fields of coronary arteries and 4D surface extraction using rotational x-ray angiography

    Energy Technology Data Exchange (ETDEWEB)

    Jandt, Uwe; Schaefer, Dirk; Grass, Michael [Philips Research Europe-Hamburg, Roentgenstr. 24, 22335 Hamburg (Germany); Rasche, Volker [University of Ulm, Department of Internal Medicine II, Robert-Koch-Strasse 8, 89081 Ulm (Germany)], E-mail: ujandt@gmx.de

    2009-01-07

    Rotational coronary angiography provides a multitude of x-ray projections of the contrast agent enhanced coronary arteries along a given trajectory with parallel ECG recording. These data can be used to derive motion information of the coronary arteries including vessel displacement and pulsation. In this paper, a fully automated algorithm to generate 4D motion vector fields for coronary arteries from multi-phase 3D centerline data is presented. The algorithm computes similarity measures of centerline segments at different cardiac phases and defines corresponding centerline segments as those with highest similarity. In order to achieve an excellent matching accuracy, an increasing number of bifurcations is included as reference points in an iterative manner. Based on the motion data, time-dependent vessel surface extraction is performed on the projections without the need of prior reconstruction. The algorithm accuracy is evaluated quantitatively on phantom data. The magnitude of longitudinal errors (parallel to the centerline) reaches approx. 0.50 mm and is thus more than twice as large as the transversal 3D extraction errors of the underlying multi-phase 3D centerline data. It is shown that the algorithm can extract asymmetric stenoses accurately. The feasibility on clinical data is demonstrated on five different cases. The ability of the algorithm to extract time-dependent surface data, e.g. for quantification of pulsating stenosis is demonstrated.

  9. Two Eyes on the Prize: Revealing the Complete Architectures of Planetary Systems through Transit Timing with Kepler and Spitzer

    Science.gov (United States)

    Fabrycky, Daniel; Stevenson, Kevin; Ballard, Sarah; Agol, Eric; Holman, Matthew; Bean, Jacob; Ragozzine, Darin

    2013-11-01

    The transit timing variation (TTV) technique has recently become a crucial method for determining the complete architectures (i.e., planet masses, orbital eccentricities, inclinations, and resonant properties) of extrasolar planetary systems. This technique has blossomed because of the Kepler mission's discovery of systems with multiple transiting planets and individual planets exhibiting very large TTVs. All of Kepler's results in this area so far have been for relatively short-period planets, but Kepler has also discovered dynamically-interacting systems with planets that have longer periods, similar to those of the Solar System. However, the ill-timed failure of the Kepler telescope has left us with an incomplete picture of these systems due to a lack of the required time baseline. Fortunately, Spitzer is positioned to leverage the unique potential that these planets offer, by extending the time baseline of transit observations. We propose to observe transits of seven Kepler-discovered planets in four particularly compelling systems to precisely determine their transit times. Combining the legacy Kepler transit times with the new times from Spitzer will give us the baseline that is needed to confirm and characterize these dynamically interacting systems of planets. This information will allow us to assess the complete architectures of these systems -- we will discover planets that do not transit and determine the masses and orbital properties of all the planets. For 6 planets in these systems, the TTVs will allow us to measure the planetary masses to better than 20%, which will approximately double the number of cool giant planets with known masses and radii. Several of the systems have mean-motion resonances between the planets, and characterizing these interactions yields information on the formation and migration of giant planets. The required precision and duration of these observations render Spitzer the only remaining instrument capable of such study.

  10. Estimation of Catchment Transit Time in Fuji River Basin by using an improved Tank model

    Science.gov (United States)

    Wenchao, M.; Yamanaka, T.; Wakiyama, Y.; Wang, P.

    2013-12-01

    As an important parameter that reflects the characteristics of catchments, the catchment transit time (CTT) has been given much more widely attentions especially in recent years. The CTT is defined as the time water spends travelling through a catchment to the stream network [1], and it describes how catchments retain and release water and solutes and thus control geochemical and biogeochemical cycling and contamination persistence [2]. The objectives of the present study are to develop a new approach for estimating CTT without prior information on such TTD functions and to apply it to the Fuji River basin in the Central Japan Alps Region. In this study, an improved Tank model was used to compute mean CTT and TTD functions simultaneously. It involved water fluxes and isotope mass balance. Water storage capacity in the catchment, which strongly affects CTT, is reflected in isotope mass balance more sensitively than in water fluxes. A model calibrated with observed discharge and isotope data is used for virtual age tracer computation to estimate CTT. This model does not only consider the hydrological data and physical process of the research area but also reflects the actual TTD with considering the geological condition, land use and the other catchment-hydrological conditions. For the calibration of the model, we used river discharge record obtained by the Ministry of Land, Infrastructure and Transportation, and are collecting isotope data of precipitation and river waters monthly or semi-weekly. Three sub-catchments (SC1~SC3) in the Fuji River basin was selected to test the model with five layers: the surface layer, upper-soil layer, lower-soil layer, groundwater aquifer layer and bedrock layer (Layer 1- Layer 5). The evaluation of the model output was assessed using Nash-Sutcliffe efficiency (NSE), root mean square error-observations standard deviation ratio (RSR), and percent bias (PBIAS). Using long time-series of discharge records for calibration, the simulated

  11. Computing short-interval transition matrices of a discrete-time Markov chain from partially observed data.

    Science.gov (United States)

    Charitos, Theodore; de Waal, Peter R; van der Gaag, Linda C

    2008-03-15

    Markov chains constitute a common way of modelling the progression of a chronic disease through various severity states. For these models, a transition matrix with the probabilities of moving from one state to another for a specific time interval is usually estimated from cohort data. Quite often, however, the cohort is observed at specific times with intervals that may be greater than the interval of interest. The transition matrix computed then needs to be decomposed in order to estimate the desired interval transition matrix suited to the model. Although simple to implement, this method of matrix decomposition can yet result in an invalid short-interval transition matrix with negative or complex entries. In this paper, we present a method for computing short-interval transition matrices that is based on regularization techniques. Our method operates separately on each row of the invalid short-interval transition matrix aiming to minimize an appropriate distance measure. We test our method on various matrix structures and sizes, and evaluate its performance on a real-life transition model for HIV-infected individuals. PMID:17579926

  12. Higher-order time-symmetry-breaking phase transition due to meeting of an exceptional point and a Fano resonance

    Science.gov (United States)

    Tanaka, Satoshi; Garmon, Savannah; Kanki, Kazuki; Petrosky, Tomio

    2016-08-01

    We have theoretically investigated the time-symmetry-breaking phase-transition process for two discrete states coupled with a one-dimensional continuum by solving the nonlinear eigenvalue problem for the effective Hamiltonian associated with the discrete spectrum. We obtain the effective Hamiltonian with use of the Feshbach-Brillouin-Wigner projection method. Strong energy dependence of the self-energy appearing in the effective Hamiltonian plays a key role in the time-symmetry-breaking phase transition: As a result of competition in the decay process between the Van Hove singularity and the Fano resonance, the phase transition becomes a higher-order transition when both the two discrete states are located near the continuum threshold.

  13. Transit time of mixed high pressure injection water and primary loop water in pressurized water reactor cold legs

    International Nuclear Information System (INIS)

    During an overcooling transient in a pressurized water reactor, cold water from the high pressure injection (HPI) mixes with the hot primary coolant in the cold leg. The transit time is a gauge for the assessment of the time and the velocity of the mixed flow that passes through the cold leg to the downcomer. Existing data from mixing tests at the Electric Power Research Institute (EPRI)/CREARE and EPRI/SAI facilities are analyzed. By means of models for HPI jet entrainment as well as the propagation of a gravity current, dimensionless correlations have been developed for the transit time and cold water front velocity at stagnant loop flow conditions. Based on this transit time correlation for stagnant loop flow and the limiting condition for large loop flow, a general correlation has been developed to account for the loop flow effect on transit time. These correlations unify a wide range of data obtained from five geometrically different test sections with two fluids (pure water and saline solution). In addition to the geometric factors, the governing dimensionless parameters for the transit time are the HPI jet Froude number, the Froude number for the cold-leg channel, and the ratio of loop flow to HPI flow

  14. Comparison of active-set method deconvolution and matched-filtering for derivation of an ultrasound transit time spectrum

    International Nuclear Information System (INIS)

    The quality of ultrasound computed tomography imaging is primarily determined by the accuracy of ultrasound transit time measurement. A major problem in analysis is the overlap of signals making it difficult to detect the correct transit time. The current standard is to apply a matched-filtering approach to the input and output signals. This study compares the matched-filtering technique with active set deconvolution to derive a transit time spectrum from a coded excitation chirp signal and the measured output signal. The ultrasound wave travels in a direct and a reflected path to the receiver, resulting in an overlap in the recorded output signal. The matched-filtering and deconvolution techniques were applied to determine the transit times associated with the two signal paths. Both techniques were able to detect the two different transit times; while matched-filtering has a better accuracy (0.13 μs versus 0.18 μs standard deviations), deconvolution has a 3.5 times improved side-lobe to main-lobe ratio. A higher side-lobe suppression is important to further improve image fidelity. These results suggest that a future combination of both techniques would provide improved signal detection and hence improved image fidelity. (note)

  15. Enhancing pairwise state-transition weights: A new weighting scheme in simulated tempering that can minimize transition time between a pair of conformational states

    Science.gov (United States)

    Qiao, Qin; Zhang, Hou-Dao; Huang, Xuhui

    2016-04-01

    Simulated tempering (ST) is a widely used enhancing sampling method for Molecular Dynamics simulations. As one expanded ensemble method, ST is a combination of canonical ensembles at different temperatures and the acceptance probability of cross-temperature transitions is determined by both the temperature difference and the weights of each temperature. One popular way to obtain the weights is to adopt the free energy of each canonical ensemble, which achieves uniform sampling among temperature space. However, this uniform distribution in temperature space may not be optimal since high temperatures do not always speed up the conformational transitions of interest, as anti-Arrhenius kinetics are prevalent in protein and RNA folding. Here, we propose a new method: Enhancing Pairwise State-transition Weights (EPSW), to obtain the optimal weights by minimizing the round-trip time for transitions among different metastable states at the temperature of interest in ST. The novelty of the EPSW algorithm lies in explicitly considering the kinetics of conformation transitions when optimizing the weights of different temperatures. We further demonstrate the power of EPSW in three different systems: a simple two-temperature model, a two-dimensional model for protein folding with anti-Arrhenius kinetics, and the alanine dipeptide. The results from these three systems showed that the new algorithm can substantially accelerate the transitions between conformational states of interest in the ST expanded ensemble and further facilitate the convergence of thermodynamics compared to the widely used free energy weights. We anticipate that this algorithm is particularly useful for studying functional conformational changes of biological systems where the initial and final states are often known from structural biology experiments.

  16. Enhancing pairwise state-transition weights: A new weighting scheme in simulated tempering that can minimize transition time between a pair of conformational states.

    Science.gov (United States)

    Qiao, Qin; Zhang, Hou-Dao; Huang, Xuhui

    2016-04-21

    Simulated tempering (ST) is a widely used enhancing sampling method for Molecular Dynamics simulations. As one expanded ensemble method, ST is a combination of canonical ensembles at different temperatures and the acceptance probability of cross-temperature transitions is determined by both the temperature difference and the weights of each temperature. One popular way to obtain the weights is to adopt the free energy of each canonical ensemble, which achieves uniform sampling among temperature space. However, this uniform distribution in temperature space may not be optimal since high temperatures do not always speed up the conformational transitions of interest, as anti-Arrhenius kinetics are prevalent in protein and RNA folding. Here, we propose a new method: Enhancing Pairwise State-transition Weights (EPSW), to obtain the optimal weights by minimizing the round-trip time for transitions among different metastable states at the temperature of interest in ST. The novelty of the EPSW algorithm lies in explicitly considering the kinetics of conformation transitions when optimizing the weights of different temperatures. We further demonstrate the power of EPSW in three different systems: a simple two-temperature model, a two-dimensional model for protein folding with anti-Arrhenius kinetics, and the alanine dipeptide. The results from these three systems showed that the new algorithm can substantially accelerate the transitions between conformational states of interest in the ST expanded ensemble and further facilitate the convergence of thermodynamics compared to the widely used free energy weights. We anticipate that this algorithm is particularly useful for studying functional conformational changes of biological systems where the initial and final states are often known from structural biology experiments. PMID:27389209

  17. Test MaxEnt in Social Strategy Transitions with Experimental Two-Person Constant Sum 2$\\times$2 Games

    OpenAIRE

    Xu, Bin; Wang, Zhijian

    2012-01-01

    By using laboratory experimental data, we test the uncertainty of social strategy transitions in various competing environments of fixed paired two-person constant sum $2 \\times 2$ games. It firstly shows that, the distributions of social strategy transitions are not erratic but obey the principle of the maximum entropy (MaxEnt). This finding indicates that human subject social systems and natural systems could have wider common backgrounds.

  18. Going Through the Rites of Passage: Timing and Transition of Menarche, Childhood Sexual Abuse, and Anxiety Symptoms in Girls

    OpenAIRE

    Natsuaki, Misaki N.; Leve, Leslie D.; Mendle, Jane

    2010-01-01

    Menarche is a discrete, transitional event that holds considerable personal, social, biological, and developmental significance. The present longitudinal study examined both the transition and timing of menarche on the trajectory of anxiety in girls with histories of childhood maltreatment (N = 93; 63% European American, 14% multiracial, 10% Latino, 9% African American, and 4% Native American). We hypothesized that because menarche is a novel, unfamiliar experience, girls would show greater a...

  19. Robust Guaranteed Cost Observer Design for Singular Markovian Jump Time-Delay Systems with Generally Incomplete Transition Probability

    OpenAIRE

    2013-01-01

    This paper is devoted to the investigation of the design of robust guaranteed cost observer for a class of linear singular Markovian jump time-delay systems with generally incomplete transition probability. In this singular model, each transition rate can be completely unknown or only its estimate value is known. Based on stability theory of stochastic differential equations and linear matrix inequality (LMI) technique, we design an observer to ensure that, for all uncertainties, the resultin...

  20. Estimation of Time-Varying Channel State Transition Probabilities for Cognitive Radio Systems by means of Particle Swarm Optimization

    OpenAIRE

    A. Akbulut; T. Adiguzel; YILMAZ, A. E.

    2012-01-01

    In this study, Particle Swarm Optimization is applied for the estimation of the channel state transition probabilities. Unlike most other studies, where the channel state transition probabilities are assumed to be known and/or constant, in this study, these values are realistically considered to be time-varying parameters, which are unknown to the secondary users of the cognitive radio systems. The results of this study demonstrate the following: without any a priori information about the cha...

  1. Impact of neonate haematocrit variability on the longitudinal relaxation time of blood: Implications for arterial spin labelling MRI

    Directory of Open Access Journals (Sweden)

    J.B. De Vis

    2014-01-01

    Conclusion: We demonstrated a wide variability of the T1b in neonates and the implications it could have in methods relying on the actual T1b as for instance ASL. It was concluded that arterial-drawn Hct values obtained from a point-of-care device can be used to infer the T1b whereas our data did not support the use of capillary-drawn Hct for T1b correction.

  2. Incidence and Severity of Coronary Artery Disease in Patients with Atrial Fibrillation Undergoing First-Time Coronary Angiography

    OpenAIRE

    Kralev, Stefan; Schneider, Kathrin; Lang, Siegfried; Süselbeck, Tim; Borggrefe, Martin

    2011-01-01

    Background In standard reference sources, the incidence of coronary artery disease (CAD) in patients with atrial fibrillation (AF) ranged between 24 and 46.5%. Since then, the incidence of cardiovascular risk factors (CRF) has increased and modern treatment strategies (“pill in the pocket”) are only applicable to patients without structural heart disease. The aim of this study was to investigate the incidence and severity of CAD in patients with AF. Methods From January 2005 until December 20...

  3. Mean Transit Times in Seven Upland Catchments, Otway Basin, Southeast Australia

    Science.gov (United States)

    Howcroft, William; Cartwright, Ian; Morgenstern, Uwe

    2016-04-01

    The timescales over which precipitation is transmitted into upland streams (the mean transit times, MTTs) are poorly understood, as are the physical processes and controls that govern the variation in mean transit times. In this study, we use tritium (3H), major ion geochemistry and discharge data to investigate the MTTs in upland streams of the Otway Basin of southeast Australia. Samples were collected under varying discharge conditions from seven catchments of varying size whose land use varies from relatively pristine eucalyptus forest to a mixture of pasture, grazing, and production forestry. This allows the controls on MTTs to be assessed. Tritium activities within the streams varied from 0.20 to 2.35 TU, which are below that of local rainfall (~2.7 TU). The highest tritium activities were generally reported in samples collected during periods of high winter discharge, while the lowest tritium activities were reported in samples collected during low, summer discharge. However, at several of the streams, there appears to be a discharge threshold above which tritium activities do not increase appreciably with increased discharge. In general, streams with larger catchment areas and relatively simple geology have less variable but higher tritium activities. In contrast, the lowest and most variable tritium activities were reported in streams having small catchment areas and a greater complexity in geology. MTTs calculated using an exponential-piston flow model ranged between 8 and 180 years; MTTs calculated using other flow models were generally similar, except where the tritium activities were less than around 1 TU. Major ion concentrations generally increased with a corresponding increase in MTT. However, in those streams having more variable MTTs, the opposite often held true, which most likely reflects the variable contribution to flow by water from different geologic units under differing flow conditions. By contrast, land use does not appear to impart a

  4. Optimal Blood Suppression inversion time based on breathing rates and heart rates to improve renal artery visibility in spatial labeling with multiple inversion pulses: A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Yi Gang; Li, Fang; Long, Xue Ying; Liu, Hui; Wang, Xiao Yi; Liu, Jin Kang; Li, Wen Zheng [Dept. of Radiology, Xiangya Hospital, Central South University, Changsha (China); Shen, Hao [GE Healthcare, Waukesha (United States)

    2016-02-15

    To determine whether an optimal blood suppression inversion time (BSP TI) can boost arterial visibility and whether the optimal BSP TI is related to breathing rate (BR) and heart rate (HR) for hypertension subjects in spatial labeling with multiple inversion pulses (SLEEK). This prospective study included 10 volunteers and 93 consecutive hypertension patients who had undergone SLEEK at 1.5T MRI system. Firstly, suitable BSP TIs for displaying clearly renal artery were determined in 10 volunteers. Secondly, non-contrast enhanced magnetic resonance angiography with the suitable BSP TIs were performed on those hypertension patients. Then, renal artery was evaluated and an optimal BSP TI to increase arterial visibility was determined for each patient. Patients' BRs and HRs were recorded and their relationships with the optimal BSP TI were analyzed. The optimal BSP TI was negatively correlated with BR (r1 = -0.536, P1 < 0.001; and r2 = -0.535, P2 < 0.001) and HR (r1 = -0.432, P1 = 0.001; and r2 = -0.419, P2 = 0.001) for 2 readers (κ = 0.93). For improving renal arterial visibility, BSP TI = 800 ms could be applied as the optimal BSP TI when the 95% confidence interval were 17-19/min (BR1) and 74-82 bpm (HR1) for reader#1 and 17-19/min (BR2) and 74-83 bpm (HR2) for reader#2; BSP TI = 1100 ms while 14-15/min (BR1, 2) and 71-76 bpm (HR1, 2) for both readers; and BSP TI = 1400 ms when 13-16/min (BR1) and 63-68 bpm (HR1) for reader#1 and 14-15/min (BR2) and 64-70 bpm (HR2) for reader#2. In SLEEK, BSP TI is affected by patients' BRs and HRs. Adopting the optimal BSP TI based on BR and HR can improve the renal arterial visibility and consequently the working efficiency.

  5. [Transposition of Great Artery].

    Science.gov (United States)

    Konuma, Takeshi; Shimpo, Hideto

    2015-07-01

    Transposition of the great artery is one of common congenital cardiac disease resulting cyanosis. Death occurs easily in untreated patients with transposition and intact ventricular septal defect (VSD) in infancy at a few days of age when posterior descending coronary artery (PDA) closed. Since there are 2 parallel circulations, flow from pulmonary to systemic circulation is necessary for systemic oxygenation, and Balloon atrial septostomy or prostaglandin infusion should be performed especially if patient do not have VSD. Although the advent of fetal echocardiography, it is difficult to diagnose the transposition of the great arteries (TGA) as abnormality of great vessels is relatively undistinguishable. The diagnosis of transposition is in itself an indication for surgery, and arterial switch procedure is performed in the case the left ventricle pressure remains more than 2/3 of systemic pressure. Preoperative diagnosis is important as associated anomalies and coronary artery branching patterns are important to decide the operative indication and timing of surgery.

  6. Effects of Cereal, Fruit and Vegetable Fibers on Human Fecal Weight and Transit Time: A Comprehensive Review of Intervention Trials.

    Science.gov (United States)

    de Vries, Jan; Birkett, Anne; Hulshof, Toine; Verbeke, Kristin; Gibes, Kernon

    2016-03-01

    Cereal fibers are known to increase fecal weight and speed transit time, but far less data are available on the effects of fruits and vegetable fibers on regularity. This study provides a comprehensive review of the impact of these three fiber sources on regularity in healthy humans. We identified English-language intervention studies on dietary fibers and regularity and performed weighted linear regression analyses for fecal weight and transit time. Cereal and vegetable fiber groups had comparable effects on fecal weight; both contributed to it more than fruit fibers. Less fermentable fibers increased fecal weight to a greater degree than more fermentable fibers. Dietary fiber did not change transit time in those with an initial time of food sources of fiber on bowel function and regularity since 1993. PMID:26950143

  7. Measuring space-time variation of the fundamental constants with redshifted submillimetre transitions of neutral carbon

    CERN Document Server

    Curran, S J; Koch, F E; Berengut, J C; Webb, J K; Stark, A A; Flambaum, V V

    2011-01-01

    We compare the redshifts of neutral carbon and carbon monoxide in the redshifted sources in which the fine structure transition of neutral carbon, [CI], has been detected, in order to measure space-time variation of the fundamental constants. Comparison with the CO rotational lines measures gives the same combination of constants obtained from the comparison fine structure line of singly ionised carbon, [CII]. However, neutral carbon has the distinct advantage that it may be spatially coincident with the carbon monoxide, whereas [CII] could be located in the diffuse medium between molecular clouds, and so any comparison with CO could be dominated by intrinsic velocity differences. Using [CI], we obtain a mean variation of dF/F = (-3.6 +/- 8.5) x 10^-5, over z = 2.3 - 4.1, for the eight [CI] systems, which degrades to (-1.5+/- 11) x 10^-5, over z = 2.3 - 6.4 when the two [CII] systems are included. That is, zero variation over look-back times of 10.8-12.8 Gyr. However, the latest optical results indicate a spa...

  8. The Effect of Sex and Age on Small Intestinal Transit Times in Humans.

    Science.gov (United States)

    Fischer, Monika; Fadda, Hala M

    2016-02-01

    This study utilizes a novel approach of small bowel video capsule endoscopy for investigating the influence of sex and age on small intestinal transit times (SITT) in humans. A total of 81 outpatients undergoing investigations with the small bowel video capsule endoscope (SB-VCE) and meeting inclusion criteria were included in this study. Following an overnight fast, patients swallowed the SB-VCE with a glass of water. SITT were calculated from the first duodenal image to the first cecal image. This study showed that the SB-VCE provides accurate and reliable measurements of SITT under real-life conditions. A large inter-individual variability in SITT was observed, with times ranging from 50 to 460 min. This variability can have implications on drug absorption and bioavailability. The median SITT were 219 min for females and 191 min for males. Although SITT were 28 min longer in females than males, this difference was not found to be statistically significant (p = 0.66). No correlation was found between age and SITT (Pearson correlation coefficient 0.19). Therefore, any drug bioavailability differences of modified release dosage preparations that are observed between adult patient groups of different age or sex are unlikely to be attributable to SITT. PMID:26308649

  9. Transit Timing Observations from Kepler: II. Confirmation of Two Multiplanet Systems via a Non-parametric Correlation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ford, Eric B.; /Florida U.; Fabrycky, Daniel C.; /Lick Observ.; Steffen, Jason H.; /Fermilab; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Holman, Matthew J.; /Harvard-Smithsonian Ctr. Astrophys.; Lissauer, Jack J.; /NASA, Ames; Moorhead, Althea V.; /Florida U.; Morehead, Robert C.; /Florida U.; Ragozzine, Darin; /Harvard-Smithsonian Ctr. Astrophys.; Rowe, Jason F.; /NASA, Ames /SETI Inst., Mtn. View /San Diego State U., Astron. Dept.

    2012-01-01

    We present a new method for confirming transiting planets based on the combination of transit timing variations (TTVs) and dynamical stability. Correlated TTVs provide evidence that the pair of bodies are in the same physical system. Orbital stability provides upper limits for the masses of the transiting companions that are in the planetary regime. This paper describes a non-parametric technique for quantifying the statistical significance of TTVs based on the correlation of two TTV data sets. We apply this method to an analysis of the transit timing variations of two stars with multiple transiting planet candidates identified by Kepler. We confirm four transiting planets in two multiple planet systems based on their TTVs and the constraints imposed by dynamical stability. An additional three candidates in these same systems are not confirmed as planets, but are likely to be validated as real planets once further observations and analyses are possible. If all were confirmed, these systems would be near 4:6:9 and 2:4:6:9 period commensurabilities. Our results demonstrate that TTVs provide a powerful tool for confirming transiting planets, including low-mass planets and planets around faint stars for which Doppler follow-up is not practical with existing facilities. Continued Kepler observations will dramatically improve the constraints on the planet masses and orbits and provide sensitivity for detecting additional non-transiting planets. If Kepler observations were extended to eight years, then a similar analysis could likely confirm systems with multiple closely spaced, small transiting planets in or near the habitable zone of solar-type stars.

  10. A study on the pulmonary mean transit time and the pulmonary blood volume by RI-cardiogram

    International Nuclear Information System (INIS)

    The pulmonary mean transit time and the pulmonary blood volume in cases of cardio-pulmonary disease were measured using Giuntini's method which is considered the most appropriate among radiocardiographic methods. The errors in this method were confirmed to be almost negligible. The results obtained were as follows: 1) The pulmonary mean transit time was related to the systemic mean transit time and markedly prolonged in left heart failure. On the other hand, it was markedly shortened in some cases of chronic pulmonary disease, particularly pulmonary emphysema. 2) The pulmonary blood volume tended to increase in left heart disorders and mitral valve disease and tended to decrease in the chronic pulmonary disease. The decrease was conspicuous particularly in some cases of pulmonary emphysema. 3) A structural change of the pulmonary vascular system in the chronic pulmonary disease appeared to bring about shortening of the pulmonary mean transit time and a decrease in the pulmonary blood volume. The pathophysiology of cardio-pulmonary disease can be more clarified by the RI-cardiogram used in this study, in which the pulmonary mean transit time and the pulmonary blood volume are used as the indicator. (author)

  11. Three-Dimensional Time-of-Flight Magnetic Resonance Angiography Detection of Duplication of the Vertebral Artery in a Large Chinese Population

    Science.gov (United States)

    Li, Shuhua; Li, Yunyun; Bai, Min; Zhang, Chuanchen

    2016-01-01

    Background The aim of this study was to investigate duplication of the vertebral artery (VA) using three-dimensional time-of-flight (3D TOF) magnetic resonance angiography (MRA) in a large study population to further our understanding of vascular variations. Material/Methods A retrospective analysis of 3D TOF-MRA data in 12 826 cases was performed. The occurrence rate of VA duplication was calculated and accompanied vascular anomalies were recoded. Results Twenty-one VA duplication patients were found, with an occurrence rate of 0.164%; 12 of them had left VA duplication with 2 branches initially arising from the aortic arch and left subclavian artery; 9 of them were right VA duplication with the branches originating from the right subclavian artery. In the 21 cases, 11 had other vascular abnormalities. Conclusions VA duplication is very rare and often associated with other vascular abnormalities. 3D TOF-MRA can accurately display the duplication variation. Better understanding of the variation is instrumental for disease diagnosis, interventional therapy, and surgical operation. PMID:27749814

  12. Characterization of the K2-19 Multiple-Transiting Planetary System via High-Dispersion Spectroscopy, AO Imaging, and Transit Timing Variations

    CERN Document Server

    Narita, Norio; Fukui, Akihiko; Hori, Yasunori; Sanchis-Ojeda, Roberto; Winn, Joshua N; Ryu, Tsuguru; Kusakabe, Nobuhiko; Kudo, Tomoyuki; Onitsuka, Masahiro; Delrez, Laetitia; Gillon, Michael; Jehin, Emmanuel; McCormac, James; Holman, Matthew; Izumiura, Hideyuki; Takeda, Yoichi; Tamura, Motohide; Yanagisawa, Kenshi

    2015-01-01

    K2-19 (EPIC201505350) is a unique planetary system in which two transiting planets with radii ~ 7 $R_{Earth}$ (inner planet b) and ~ 4 $R_{Earth}$ (outer planet c) have orbits that are nearly in a 3:2 mean-motion resonance. Here, we present results of ground-based follow-up observations for the K2-19 planetary system. We have performed high-dispersion spectroscopy and high-contrast adaptive-optics imaging of the host star with the HDS and HiCIAO on the Subaru 8.2m telescope. We find that the host star is relatively old (>8 Gyr) late G-type star ($T_{eff}$ ~ 5350 K, $M_s$ ~ 0.9 $M_{Sun}$, and $R_{s}$ ~ 0.9 $R_{Sun}$). We do not find any contaminating faint objects near the host star which could be responsible for (or dilute) the transit signals. We have also conducted transit follow-up photometry for the inner planet with KeplerCam on the FLWO 1.2m telescope, TRAPPISTCAM on the TRAPPIST 0.6m telescope, and MuSCAT on the OAO 1.88m telescope. We confirm the presence of transit-timing variations, as previously re...

  13. Scintigraphic determination of small intestinal transit time of water in man

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, E.K.; Caride, V.J.; Marano, A.R.; McCallum, R.

    1984-01-01

    A method utilizing a lactulose solution to measure small intestinal transit time (SITT) has been previously reported. Lactulose is a non-absorbable sugar and is known to increase SITT. In order to determine the extent to which lactulose accelerates SITT, a group of 4 normal male volunteers were studied after the ingestion of 150cc of water to which 100 uCi of 111-In was added. To provide adequate caloric intake, as occurs physiologically, the water was drunk while ingesting a solid meal. The subject was then placed supine under a 15 inch gamma camera. Data were collected and stored in a computer at one frame every 3 minute for 240 minutes. If activity was not present in the cecal region by this time, the subject was allowed to move about for 15 minutes and then repositioned under the gamma camera. Data were first viewed in a movie format. Regions of interest were selected over the cecum and ascending colon. The time of first appearance of radioactivity in the region of the cecum was taken as the SITT. Each subject was studied on three separate occasions. The mean (+- SEM) SITT for each of the separate studies was 248 +- 58 min., 240 +- 47 min. and 232 +- 54 min. respectively (pless than or equal toNS). Two previously studied groups of normal volunteers had a mean SITT of approximately 80 minutes. Water appears to have a significantly slower SITT when ingested with a solid meal when compared to lactulose. Clinically, the potential to use water as a test for SITT would not seem to be as attractive or practical as using lactulose as the test substance.

  14. Kepler-9: A System of Multiple Planets Transiting a Sun-Like Star, Confirmed by Timing Variations

    Science.gov (United States)

    Holman, Matthew J.; Fabrycky, Daniel C.; Ragozzine, Darin; Ford, Eric B.; Steffen, Jason H.; Welsh, William F.; Lissauer, Jack J.; Latham, David W.; Marcy, Geoffrey W.; Walkowicz, Lucianne M.; Batalha, Natalie M.; Jenkins, Jon M.; Rowe, Jason F.; Cochran, William D.; Fressin, Francois; Torres, Guillermo; Buchhave, Lars A.; Sasselov, Dimitar D.; Borucki, William J.; Koch, David G.; Basri, Gibor; Brown, Timothy M.; Caldwell, Douglas A.; Charbonneau, David; Dunham, Edward W.; Gautier, Thomas N.; Geary, John C.; Gilliland, Ronald L.; Haas, Michael R.; Howell, Steve B.; Ciardi, David R.; Endl, Michael; Fischer, Debra; Fürész, Gábor; Hartman, Joel D.; Isaacson, Howard; Johnson, John A.; MacQueen, Phillip J.; Moorhead, Althea V.; Morehead, Robert C.; Orosz, Jerome A.

    2010-10-01

    The Kepler spacecraft is monitoring more than 150,000 stars for evidence of planets transiting those stars. We report the detection of two Saturn-size planets that transit the same Sun-like star, based on 7 months of Kepler observations. Their 19.2- and 38.9-day periods are presently increasing and decreasing at respective average rates of 4 and 39 minutes per orbit; in addition, the transit times of the inner body display an alternating variation of smaller amplitude. These signatures are characteristic of gravitational interaction of two planets near a 2:1 orbital resonance. Six radial-velocity observations show that these two planets are the most massive objects orbiting close to the star and substantially improve the estimates of their masses. After removing the signal of the two confirmed giant planets, we identified an additional transiting super-Earth-size planet candidate with a period of 1.6 days.

  15. Stochastic Stability for Time-Delay Markovian Jump Systems with Sector-Bounded Nonlinearities and More General Transition Probabilities

    Directory of Open Access Journals (Sweden)

    Dan Ye

    2013-01-01

    Full Text Available This paper is concerned with delay-dependent stochastic stability for time-delay Markovian jump systems (MJSs with sector-bounded nonlinearities and more general transition probabilities. Different from the previous results where the transition probability matrix is completely known, a more general transition probability matrix is considered which includes completely known elements, boundary known elements, and completely unknown ones. In order to get less conservative criterion, the state and transition probability information is used as much as possible to construct the Lyapunov-Krasovskii functional and deal with stability analysis. The delay-dependent sufficient conditions are derived in terms of linear matrix inequalities to guarantee the stability of systems. Finally, numerical examples are exploited to demonstrate the effectiveness of the proposed method.

  16. Characters available in photoplethysmogram for blood pressure estimation: beyond the pulse transit time.

    Science.gov (United States)

    Li, Yanjun; Wang, Zengli; Zhang, Lin; Yang, Xianglin; Song, Jinzhong

    2014-06-01

    The continuous and noninvasive blood pressure (BP) measurement based on pulse transit time (PTT) doesn't need cuff and could monitor BP in real time for a long period. However, PTT is just a time index derived from electrocardiogram (ECG) and photoplethysmogram (PPG), while BP-related information within the PPG waveform has seldom been taken into consideration. We hypothesized that PPG waveform feature might be useful for BP estimation. Nine healthy subjects took part in an exercise stress test, including baseline resting, exercise on bicycle ergometry and recovering resting. ECG of lead V5 and PPG from left finger were collected simultaneously, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded from a cuff sphygmometer on the right wrist. The correlation coefficients were obtained between BP (SBP, DBP and pulse pressure (PP)) and PPG morphological indices (total 15 indices in terms of waveform amplitude, time span and area ratio). Five PPG indices were correlated with both SBP and PP (absolute value of correlation coefficient |r| > 0.6) and were further tested for the capability to BP estimation, which were: (1) PTTA, time delay between the R peak of ECG and the foot point of PPG; (2) RSD, time ratio of systole to diastole; (3) RtArea, area ratio of systole to diastole; (4) TmBB, time span of PPG cycle; (5) TmCA, diastolic duration. Comparisons were made between the measured BP and the estimated BP by regression lines and quadratic curve fitting, respectively. As a result, the mean errors of SBP liner fitting with RSD, RtArea, TmBB and TmCA respectively were 5.5, 5.4, 5.2, 5.1 mmHg, which were smaller than that with PTTA of 5.8 mmHg. And the mean errors of SBP quadratic curve fitting with RSD, RtArea, TmBB and TmCA were all 5.1 mmHg, which were smaller than that with PTTA of 5.7 mmHg. The mean errors of multiple regression for SBP, PP and DBP was 4.7, 4.7, 3.5 mmHg respectively, which were more accurate than the regression with

  17. Time-Dependent CP Asymmetries in B0 -> Ks pi0 gamma transitions

    CERN Document Server

    Abe, K; Aihara, H; Anipko, D; Aoki, K; Arakawa, T; Arinstein, K; Asano, Y; Aso, T; Aulchenko, V M; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Barbero, M; Bay, A; Bedny, I; Belous, K S; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chistov, R; Choi, J H; Choi, S K; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dowd, R; Dragic, J; Drutskoy, A; Eidelman, S; Enari, Y; Epifanov, D A; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Gorisek, A; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hokuue, T; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Igarashi, Y; Iijima, T; Ikado, K; Imoto, A; Inami, K; Ishikawa, A; Ishino, H; Itoh, K; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Jones, M; Kakuno, H; Kang, J H; Kang, J S; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kibayashi, A; Kichimi, H; Kikuchi, N; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, T H; Kim, Y J; Kinoshita, K; Kishimoto, N; Korpar, S; Kozakai, Y; Krizan, P; Krokovnyi, P P; Kubota, T; Kulasiri, R; Kumar, R; Kuo, C C; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, S E; Lee, Y J; Lesiak, T; Li, J; Limosani, A; Lin, C Y; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mohapatra, D; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakagawa, T; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Ronga, F J; Root, N; Rorie, J; Rózanska, M; Sahoo, H; Saitoh, S; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Sato, N; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Seki, T; Senyo, K; Sevior, M E; Shapkin, M; Shen, Y T; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Stöck, H; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takada, N; Takasaki, F; Tamai, K; Tamura, N; Tanabe, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Trabelsi, K; Tsai, Y T; Tse, Y F; Tsuboyama, T; Tsukamoto, T; Uchida, K; Uchida, Y; Uehara, S; Uglov, T; Ueno, K; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Wang, M Z; Watanabe, M; Watanabe, Y; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Wu, C H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamamoto, S; Yamashita, Y; Yamauchi, M; Heyoung Yang; Yoshino, S; Yuan, Y; Yusa, Y; Zang, S L; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Ziegler, T; Zupanc, A; Zürcher, D; al, et

    2006-01-01

    We report measurements of CP-violation parameters in B0 -> Ks pi0 gamma transitions based on a data sample that contains 535MBB pairs that was collected near the Upsilon(4S) resonance, with the Belle detector at the KEKB asymmetric energy e+e- collider. One neutral B meson is fully reconstructed in the B0 -> Ks pi0 gamma decay channel with Ks pi0 invariant mass up to 1.8 GeV/c^2. The flavor of the accompanying B meson is identified from its decay products. CP-violation parameters, S and A, are obtained from the asymmetries in the distribution of the proper-time intervals between the two B decays. We measure S and A in two Ks pi0 invariant mass regions. For the full range of Ks pi0 invariant mass up to 1.8 GeV/c^2 we obtain S_Kspi0gamma = -0.10 +- 0.31(stat) +- 0.07(syst) and A_Kspi0gamma = -0.20 +- 0.20(stat) +- 0.06(syst). Restricting to Ks pi0 mass around K*0(892) resonance (0.8 to 1.0 GeV/c^2), we obtain S_K*gamma = -0.32 +0.36-0.33(stat) +- 0.05(syst) and A_K*gamma = -0.20 +-0.24(stat) +- 0.05(syst).

  18. Real-time observation of nanoscale topological transitions in epitaxial PbTe/CdTe heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Groiss, H., E-mail: heiko.groiss@jku.at, E-mail: istvan.daruka@jku.at; Daruka, I., E-mail: heiko.groiss@jku.at, E-mail: istvan.daruka@jku.at; Springholz, G.; Schäffler, F. [Institute of Semiconductor and Solid State Physics, Johannes Kepler University, Linz 4040 (Austria); Koike, K.; Yano, M. [Nanomaterials Microdevices Research Center, Osaka Institute of Technology, Asahi-ku Ohmiya, Osaka 535-8585 (Japan); Hesser, G. [Center for Surface- and Nanoanalytics (ZONA), Johannes Kepler University, Linz 4040 (Austria); Zakharov, N.; Werner, P. [Max Planck Institute of Microstructure Physics, Halle 06120 (Germany)

    2014-01-01

    The almost completely immiscible PbTe/CdTe heterostructure has recently become a prototype system for self-organized quantum dot formation based on solid-state phase separation. Here, we study by real-time transmission electron microscopy the topological transformations of two-dimensional PbTe-epilayers into, first, a quasi-one-dimensional percolation network and subsequently into zero-dimensional quantum dots. Finally, the dot size distribution coarsens by Ostwald ripening. The whole transformation sequence occurs during all stages in the fully coherent solid state by bulk diffusion. A model based on the numerical solution of the Cahn-Hilliard equation reproduces all relevant morphological and dynamic aspects of the experiments, demonstrating that this standard continuum approach applies to coherent solids down to nanometer dimensions. As the Cahn-Hilliard equation does not depend on atomistic details, the observed morphological transformations are general features of the model. To confirm the topological nature of the observed shape transitions, we developed a parameter-free geometric model. This, together with the Cahn-Hilliard approach, is in qualitative agreement with the experiments.

  19. Men, maternity and moral residue: negotiating the moral demands of the transition to first time fatherhood.

    Science.gov (United States)

    Ives, Jonathan

    2014-09-01

    This article discusses men's transition to first time fatherhood, with a focus on the way they recognise various in-tension moral demands and negotiate an appropriate role for themselves. The findings are taken from a longitudinal study, drawing on elements of grounded theory, comprising a series of face-to-face and telephone interviews with 11 men over a 9-month period from the 12(th) week of pregnancy to 8 weeks after the birth. The analysis focuses on men's feelings and experience of exclusion and participation, and their response and reaction to that experience. The findings present two descriptive themes, 'on the inside looking in' and 'present but not participating', followed by third theme 'deference and support: a moral response' that exposes the dilemmatic nature of men's experience and explains the participants' apparent acceptance of being less involved. The discussion explores the concept of moral residue, arguing that while deference and support may be an appropriate role for fathers in the perinatal period it may also be a compromise that leads to feelings of uncertainty and frustration, which is a consequence of being in a genuinely dilemmatic situation.

  20. Densities and eccentricities of 139 Kepler planets from transit time variations

    Energy Technology Data Exchange (ETDEWEB)

    Hadden, Sam; Lithwick, Yoram [Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States)

    2014-05-20

    We extract densities and eccentricities of 139 sub-Jovian planets by analyzing transit time variations (TTVs) obtained by the Kepler mission through Quarter 12. We partially circumvent the degeneracies that plague TTV inversion with the help of an analytical formula for the TTV. From the observed TTV phases, we find that most of these planets have eccentricities of the order of a few percent. More precisely, the rms eccentricity is 0.018{sub −0.004}{sup +0.005}, and planets smaller than 2.5 R {sub ⊕} are around twice as eccentric as those bigger than 2.5 R {sub ⊕}. We also find a best-fit density-radius relationship ρ ≈ 3 g cm{sup –3} × (R/3 R {sub ⊕}){sup –2.3} for the 56 planets that likely have small eccentricity and hence small statistical correction to their masses. Many planets larger than 2.5 R {sub ⊕} are less dense than water, implying that their radii are largely set by a massive hydrogen atmosphere.

  1. Transit timing variation and transmission spectroscopy analyses of the hot Neptune GJ3470b

    Science.gov (United States)

    Awiphan, S.; Kerins, E.; Pichadee, S.; Komonjinda, S.; Dhillon, V. S.; Rujopakarn, W.; Poshyachinda, S.; Marsh, T. R.; Reichart, D. E.; Ivarsen, K. M.; Haislip, J. B.

    2016-08-01

    GJ3470b is a hot Neptune exoplanet orbiting an M dwarf and the first sub-Jovian planet to exhibit Rayleigh scattering. We present transit timing variation (TTV) and transmission spectroscopy analyses of multi-wavelength optical photometry from 2.4-m and 0.5-m telescopes at the Thai National Observatory, and the 0.6-m PROMPT-8 telescope in Chile. Our TTV analysis allows us to place an upper mass limit for a second planet in the system. The presence of a hot Jupiter with a period of less than 10 days or a planet with an orbital period between 2.5 and 4.0 days are excluded. Combined optical and near-infrared transmission spectroscopy favour a H/He dominated haze (mean molecular weight 1.08 ± 0.20) with high particle abundance at high altitude. We also argue that previous near-infrared data favour the presence of methane in the atmosphere of GJ3470b.

  2. Timing, cause and consequences of mid-Holocene climate transition in the Arabian Sea

    Science.gov (United States)

    Saraswat, Rajeev; Naik, Dinesh Kumar; Nigam, Rajiv; Gaur, Anuruddh Singh

    2016-09-01

    We reconstruct centennial scale quantitative changes in surface seawater temperature (SST), evaporation-precipitation (from Mg/Ca and δ18O of surface dwelling planktic foraminifera), productivity (from relative abundance of Globigerina bulloides), carbon burial (from %CaCO3 and organic carbon [%Corg]) and dissolved oxygen at sediment-water interface, covering the entire Holocene, from a core collected from the eastern Arabian Sea. From the multi-proxy record, we define the timing, consequences and possible causes of the mid-Holocene climate transition (MHCT). A distinct shift in evaporation-precipitation (E-P) is observed at 6.4 ka, accompanied by a net cooling of SST. The shift in SST and E-P is synchronous with a change in surface productivity. A concurrent decrease is also noted in both the planktic foraminiferal abundance and coarse sediment fraction. A shift in carbon burial, as inferred from both the %CaCO3 and %Corg, coincides with a change in surface productivity. A simultaneous decrease in dissolved oxygen at the sediment-water interface, suggests that changes affected both the surface and subsurface water. A similar concomitant change is also observed in other cores from the Arabian Sea as well as terrestrial records, suggesting a widespread regional MHCT. The MHCT coincides with decreasing low-latitude summer insolation, perturbations in total solar intensity and an increase in atmospheric CO2.

  3. Real-time observation of nanoscale topological transitions in epitaxial PbTe/CdTe heterostructures

    Directory of Open Access Journals (Sweden)

    H. Groiss

    2014-01-01

    Full Text Available The almost completely immiscible PbTe/CdTe heterostructure has recently become a prototype system for self-organized quantum dot formation based on solid-state phase separation. Here, we study by real-time transmission electron microscopy the topological transformations of two-dimensional PbTe-epilayers into, first, a quasi-one-dimensional percolation network and subsequently into zero-dimensional quantum dots. Finally, the dot size distribution coarsens by Ostwald ripening. The whole transformation sequence occurs during all stages in the fully coherent solid state by bulk diffusion. A model based on the numerical solution of the Cahn-Hilliard equation reproduces all relevant morphological and dynamic aspects of the experiments, demonstrating that this standard continuum approach applies to coherent solids down to nanometer dimensions. As the Cahn-Hilliard equation does not depend on atomistic details, the observed morphological transformations are general features of the model. To confirm the topological nature of the observed shape transitions, we developed a parameter-free geometric model. This, together with the Cahn-Hilliard approach, is in qualitative agreement with the experiments.

  4. Developments in Time-Division Multiplexing of X-ray Transition-Edge Sensors

    Science.gov (United States)

    Doriese, W. B.; Morgan, K. M.; Bennett, D. A.; Denison, E. V.; Fitzgerald, C. P.; Fowler, J. W.; Gard, J. D.; Hays-Wehle, J. P.; Hilton, G. C.; Irwin, K. D.; Joe, Y. I.; Mates, J. A. B.; O'Neil, G. C.; Reintsema, C. D.; Robbins, N. O.; Schmidt, D. R.; Swetz, D. S.; Tatsuno, H.; Vale, L. R.; Ullom, J. N.

    2016-07-01

    Time-division multiplexing (TDM) is a mature scheme for the readout of arrays of transition-edge sensors (TESs). TDM is based on superconducting-quantum-interference-device (SQUID) current amplifiers. Multiple spectrometers based on gamma-ray and X-ray microcalorimeters have been operated with TDM readout, each at the scale of 200 sensors per spectrometer, as have several astronomical cameras with thousands of sub-mm or microwave bolometers. Here we present the details of two different versions of our TDM system designed to read out X-ray TESs. The first has been field-deployed in two 160-sensor (8 columns × 20 rows) spectrometers and four 240-sensor (8 columns × 30 rows) spectrometers. It has a three-SQUID-stage architecture, switches rows every 320 ns, and has total readout noise of 0.41 μ Φ 0 / surd Hz. The second, which is presently under development, has a two-SQUID-stage architecture, switches rows every 160 ns, and has total readout noise of 0.19 μ Φ 0 / surd Hz. Both quoted noise values are non-multiplexed and referred to the first-stage SQUID. In a demonstration of this new architecture, a multiplexed 1-column × 32-row array of NIST TESs achieved average energy resolution of 2.55± 0.01 eV at 6 keV.

  5. Securing the Extremely Low-Densities of Low-Mass Planets Characterized by Transit Timing Variations

    Science.gov (United States)

    Ford, Eric B.

    2015-12-01

    Transit timing variations (TTVs) provide an excellent tool to characterize the masses and orbits of dozens of small planets, including many at orbital periods beyond the reach of both Doppler surveys and photoevaporation-induced atmospheric loss. Dynamical modeling of these systems has identified low-mass planets with surprisingly large radii and low densities (e.g., Kepler-79d, Jontof-Hutter et al. 2014; Kepler-51, Masuda 2014; Kepler-87c, Ofir et al. 2014). Additional low-density, low-mass planets will likely become public before ESS III (Jontof-Hutter et al. in prep). Collectively, these results suggest that very low density planets with masses of 2-6 MEarth are not uncommon in compact multiple planet systems. Some astronomers have questioned whether there could be an alternative interpretation of the TTV observations. Indeed, extraordinary claims require extraordinary evidence. While the physics of TTVs is rock solid, the statistical analysis of Kepler observations can be challenging, due to the complex interactions between model parameters and high-dimensional parameter spaces that must be explored. We summarize recent advances in computational statistics that enable robust characterization of planetary systems using TTVs. We present updated analyses of a few particularly interesting systems and discuss the implications for the robustness of extremely low densities for low-mass planets. Such planets pose an interesting challenge for planet formation theory and are motivating detailed theoretical studies (e.g., Lee & Chiang 2015 and associated ESS III abstracts).

  6. Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

    International Nuclear Information System (INIS)

    Early diagnosis of cerebrovascular disease requires the accurate identification of brain regions with compromised cerebral perfusion pressure (CPP). Current clinical measures of CPP are invasive and lack regional information. Dynamic contrast-enhanced imaging provides a means of looking at regional cerebral hemodynamics. The purpose of this study was to determine if any of the parameters associated with dynamic contrast-enhanced imaging could be used as an index for CPP under graded systemic hypotension in a rabbit model. Cerebral blood flow (CBF), cerebral blood volume, mean transit time (MTT), and cerebrovascular reserve (CVR) were measured using Computed Tomography Perfusion in three groups: normotensive (n = 14), mild hypotensive (n = 9), and moderate hypotensive (n = 6). MTT demonstrated the strongest correlation with CPP (ρ = −0.642, P < 0.05). CBF was the only other parameter to demonstrate a statistically significant correlation (ρ = 0.575, P < 0.05). CVR is gaining momentum for diagnosing cerebrovascular disease; however, the technique requires patients to be given a hemodynamic challenge, which could aggravate symptoms and even trigger stroke. The results of this study suggest that the use of MTT, not requiring hemodynamic manipulation, is more sensitive to subtle changes in CPP, as would occur in the early stages of cerebrovascular disease

  7. The timing of tectonic transition from compression to extension in Dabieshan:Evidence from Mesozoic granites

    Institute of Scientific and Technical Information of China (English)

    MA Changqian; YANG Kunguang; MING Houli; LIN Guangchun

    2004-01-01

    With the methods of single grain zircon U-Pb and hornblende-biotite Ar-Ar dating, a U-Pb zircon age (135.4(2.7) Ma of Liujiawa high Sr/Y granite and 40Ar-39Ar plateau ages (139.0(1.0) Ma and (125.3(0.2) Ma of hornblende and biotite respectively of Fenliupu high Sr/Y granite in the Dabieshan high- and ultrahigh-pressure metamorphic belt are yielded. Following the emplacement of the high Sr/Y granites, extension-related mafic intrusions and late granitoids with negative Sr and Eu anomalies and isotopic ages of 105-130 Ma were emplaced. Geochemical comparison between the two types of granitoids shows that, from early to late, the alkalinities, the K2O contents and the Sr/Y ratios as well as FeO/(FeO+MgO) ratios of the rocks increase, while the abundance of Sr reduces, suggesting that as time goes on the depth of crustal melting decreases. Rheological stratification of the crust due to early Cretaceous partial melting of crustal rocks resulted in crustal extension and deep-buried rock exhumation. Therefore, the high Sr/Y granite that appeared at ~135 Ma is the product of the tectonic transition from early shortening to late overall extension.

  8. Comparison of colonic transit time findings between spastic pelvic floor syndrome and normal on defecogram

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Kwon; Choi, Sang Hee; Chung, Il Gyu; Lim, Hyo Keun; Choo, Sung Wook; Rhee, Poong Lyul [Samsung Medical Center, Seoul (Korea, Republic of)

    1998-05-01

    The purpose of this study is to evaluate colonic transit time (CTT) in patients with spastic pelvic floor syndrome (SPFS) diagnosed by defecography and compare findings with those of patients with normal defecography. Over a recent 15-month period, 140 patients underwent both defecography and CTT test because of chronic idiopathic constipation. Of these, 54 with SPFS diagnosed by defecography and 49 controls with normal defecography were included in our study. CTT test involved the radiopaque marker method. Subjects ingested 24 markers at 9:00 Am on three consecutive days and a plain film of the abdomen was obtained on day 4. We calculated total and segmental CTT test findings in the two groups. Delayed total CTT was found in 35% of patients (19/54) with SPFS. Segmental CTT in the right, left and rectosigmoid colon was delayed in 31 % of patients (15/49) with SPFS. Segmental CTT in the right, left and rectosigmoid colon was delayed in 19 % (10/54), 44 % (24/54), and 31 % of cases (17/54), respectively. Total CTT was delayed in 31 % of patients (15/49) with normal defecography. In this group, segmental CTT in the left colon was delayed in 39 % of cases. There was no significant difference in CTT findings between the SPFS and normal groups on defecogram. (author). 18 refs., 2 tabs., 5 figs.

  9. Transit timing variation and transmission spectroscopy analyses of the hot Neptune GJ3470b

    CERN Document Server

    Awiphan, S; Pichadee, S; Komonjinda, S; Dhillon, V S; Rujopakarn, W; Poshyachinda, S; Marsh, T R; Reichart, D E; Ivarsen, K M; Haislip, J B

    2016-01-01

    GJ3470b is a hot Neptune exoplanet orbiting an M dwarf and the first sub-Jovian planet to exhibit Rayleigh scattering. We present transit timing variation (TTV) and transmission spectroscopy analyses of multi-wavelength optical photometry from 2.4-m and 0.5-m telescopes at the Thai National Observatory, and the 0.6-m PROMPT-8 telescope in Chile. Our TTV analysis allows us to place an upper mass limit for a second planet in the system. The presence of a hot Jupiter with a period of less than 10 days or a planet with an orbital period between 2.5 and 4.0 days are excluded. Combined optical and near-infrared transmission spectroscopy favour a H/He dominated haze (mean molecular weight 1.18$\\pm$0.22) with high particle abundance at high altitude. We also argue that previous near-infrared data favour the presence of methane in the atmosphere of GJ3470b.

  10. A novel platelet-rich arterial thrombosis model in rabbits. Simple, reproducible, and dynamic real-time measurement by using double-opposing inverted-sutures model.

    Science.gov (United States)

    Shieh, S J; Chiu, H Y; Shi, G Y; Wu, C M; Wang, J C; Chen, C H; Wu, H L

    2001-09-01

    Though numerous animal thrombosis models have been introduced, an easy, reliable, and reproducible arterial thrombosis model remains a continuing challenge prior to a thrombolytic study. In an effort to evaluate the efficiency of various recombinant thrombolytic agents with specific affinity to activated platelets in vivo, we developed a novel double-opposing inverted-sutures model to create a platelet-rich thrombus in the femoral artery of rabbits. The arteriotomy was done semicircumferentially, and variously sized microsurgical sutures were introduced intraluminally in a double-opposing inverted manner. The animals were divided into three groups according to the double-opposing inverted-sutures used: Group 1 with 10-0 nylon (n=6), Group 2 with 9-0 nylon (n=6), and Group 3 with 8-0 nylon (n=22). The superficial epigastric branch was cannulated with a thin polyethylene (PE) tube for intraarterial administration of the studied thrombolytic agent. The blood flow was continuously measured with a real-time ultrasonic flow meter. Within 2 h of installation of the sutures, there was no thrombus formation in either Group 1 or 2. In Group 3, the thrombosis rate was 91% (20 of 22) under a steady baseline flow (with an average of 12.23+/-2.40 ml/min). It was highly statistically significant with a P-value of .0000743 using Fisher's Exact Test. The averaged time to thrombosis was 21.8+/-9.8 min. The ultrasonic flow meter to record the dynamic real-time measurement of blood flow was a guideline for thrombus formation or dissolution, which was correlated with the morphological findings of stenotic status of the vessel detected by the Doppler sonography. The components of the thrombus were proven to be platelet-rich predominant by histological examination via hematoxylin and eosin (H&E) stain and transmission electron microscopy (TEM). To confirm that the double-opposing inverted-sutures model would be useful for a study of thrombolytic agents, we evaluated the effects of

  11. Splanchnic artery aneurysms

    Directory of Open Access Journals (Sweden)

    Davidović Lazar B.

    2006-01-01

    Full Text Available Introduction. Splanchnic artery aneurysms are uncommon but important vascular entity because nearly 25% of all cases present as surgical emergency. Objective. The purpose of our study was to present nine patients operated on at the Institute of cardiovascular diseases, as well as literature review of clinical presentation of the disease. Method. There were three splenic artery aneurysms, two celiac trunk aneurysms, and one aneurysm of the hepatic, superior mesenteric, inferior mesenteric and gastroduodenal artery. All patients were males, mean aged 67.5 years (60-73. In four patients, splanchnic artery aneurysm was discovered accidentally during routine ultrasonographic and angiographic examinations of the abdominal aorta. At that time, arteriovenous fistula was diagnosed in a patient No 1; it was formed after rupture of the splenic artery aneurysm into the splenic vein. Three aneurysms were manifested by abdominal pain and palpable pulsating abdominal mass. Two patients were admitted as urgent cases in the state of hemorrhagic shock and signs of intraabdominal bleeding due to rupture of the splenic and hepatic arteries. In 7 cases, diagnosis was made preoperatively by means of ultrasonography and angiography; in two patients, accurate diagnosis was confirmed during surgery. Results. Proximal and distal ligation of the artery was performed in a patient with rupture of the splenic aneurysm into the splenic vein that caused arteriovenous fistula. Gastroduodenal artery aneurysm was treated by trans-aneurysmatic ligation of its "entering" and "exiting" branches. Aneurysms of distal part of the superior mesenteric and splenic artery were resected without further reconstruction. Partial resection of the aneurysm and endoaneurysmorrhaphy was carried out in one case of celiac trunk aneurysm, and in another, after aneurysm resection, the restoration of blood flow through the hepatic and lienal artery was achieved by Dacron grafts. In a patient with the

  12. Arterial pH and Blood Lactate Levels of Anesthetized Mongolian Khulan ( Equus hemionus hemionus) in the Mongolian Gobi Correlate with Induction Time.

    Science.gov (United States)

    Gerritsmann, Hanno; Stalder, Gabrielle L; Kaczensky, Petra; Buuveibaatar, Bayarbaatar; Payne, John; Boldbaatar, Sukhbaatar; Walzer, Chris

    2016-07-01

    Research and conservation of wide-ranging wild equids in most cases necessitate capture and handling of individuals. For free-roaming Mongolian khulan ( Equus hemionus hemionus), also known as the khulan, capture involves a strenuous, high-speed chase, and physiologic responses have yet to be elucidated. We analyzed sequential arterial blood gas (ABG) samples as a proxy for respiratory and metabolic status of khulan during capture-related anesthesia. We recorded precise chase and induction times and monitored vital parameters and ABG from free-ranging khulan during anesthesia performed for GPS collaring. At the initiation of anesthesia, animals had ABG values similar to those recorded for thoroughbred horses ( Equus caballus ) after maximal exercise. Longer induction times resulted in higher arterial pH (P<0.001) and lower blood lactate (P<0.002). This trend of improvement continued over the course of anesthesia. The most important factor explaining pH and lactate was the time that elapsed between cessation of the chase and obtaining the first ABG sample, which, under field conditions, is tightly linked to induction time. All animals recovered uneventfully. Our data show that khulan recover and shift their metabolic status back toward expected normal values during opioid-based field anesthesia. PMID:27243152

  13. Early complement activation follows eversion carotid endarterectomy and correlates with the time of clamping of the carotid artery

    DEFF Research Database (Denmark)

    Széplaki, Gábor; Hirschberg, Kristóf; Gombos, Tímea;

    2008-01-01

    BACKGROUND: Complement activation plays an important role in ischemia/reperfusion (I/R) injury. The objective of the present study was to detect the presence and mechanism of complement activation in patients who underwent carotid endarterectomy (CEA). METHODS: Complement activation products C1rsC1......-inhibitor, C4d, C3a and SC5b-9 and concentrations of C-reactive protein (CRP) were measured in samples serially taken from 16 patients with eversion CEA and 10 with carotid artery stenting (CAS) in the first 24h post-surgery/intervention. MBL2 genotypes were also determined. RESULTS: In patients with CEA...

  14. Transcatheter Arterial Chemoembolization for Liver Cancer: Is It Time to Distinguish Conventional from Drug-Eluting Chemoembolization?

    International Nuclear Information System (INIS)

    Conventional transcatheter arterial chemoembolization and chemoembolization with drug-eluting beads are increasingly being performed interchangeably in many institutions throughout the world. As both therapies continue to being tested in many phase II and III studies and in combination with other therapies, especially targeted agents, for treatment of primary and metastatic liver cancer, it is imperative to review their current status and evaluate their impact on patient survival. This review critically assesses patient selection, indications, contraindications, techniques, materials, safety, and clinical outcomes of patients treated with conventional chemoembolization and chemoembolization with drug-eluting beads.

  15. Towards a Fully Distributed Characterization of Water Residence and Transit Time by Coupled Hydrology-Transport Modeling

    Science.gov (United States)

    Remondi, F.; Fatichi, S.; Burlando, P.

    2015-12-01

    Water residence and transit time are crucial elements in flow pathways and catchment response characterization. The temporal distribution of catchment transit times has been generally studied and modelled with lumped parameter approaches. However, understanding the dominant controls in a more holistic manner requires attention to the spatially distributed catchment properties also in relation to their control on the basin response to different type of precipitation events. A tool that looks both at the time and space distribution of water residence and transport can be useful for predicting water and solute fluxes and ultimately for better understanding the dependence of catchment transit and residence times on geomorphological and climatic factors. To this purpose we couple a fully distributed, yet essential, process-based watershed model with a component to simulate solute transport. Key features of the developed tool include: (a) reduced complexity spatially-distributed hydrological model; (b) spatially-distributed water age and conservative tracer concentration; (c) possibility to explicitly compute transit time distributions for different precipitation events and locations. The presented framework is tested on the Plynlimon watershed (UK), where long-term records of hydrological variables are available. Among them, discharge and chloride concentration are used to investigate the model behavior. We present the integrated model concept, the underlying methodologies, the results from the case study application, as well as preliminary virtual experiments that allow exploring the full statistical space of travel and residence times.

  16. Fine tuning the color-transition temperature of thermoreversible polydiacetylene/zinc oxide nanocomposites: The effect of photopolymerization time.

    Science.gov (United States)

    Traiphol, Nisanart; Faisadcha, Kunruethai; Potai, Ruttayapon; Traiphol, Rakchart

    2015-02-01

    An ability to control the thermochromic behaviors of polydiacetylene (PDA)-based materials is very important for their utilization. Recently, our group has developed the PDA/zinc oxide (ZnO) nanocomposites, which exhibit reversible thermochromism (Traiphol et al., 2011). In this study, we present our continuation work demonstrating a rather simple method for fine tuning their color-transition temperature. The PDA/ZnO nanocomposites are prepared by varying photopolymerization time, which in turn affects the length of PDA conjugated backbone. We have found that the increase of photopolymerization time from 1 to 120min results in systematically decrease of the color-transition temperature from about 85 to 40°C. These PDA/ZnO nanocomposites still exhibit reversible thermochromism. The PDA/ZnO nanocomposites embedded in polyvinyl alcohol films show two-step color-transition processes, the reversible blue to purple and then irreversible purple to orange. Interestingly, the increase of photopolymerization time causes an increase of the irreversible color-transition temperature. Our method is quite simple and cheap, which can provide a library of PDA-based materials with controllable color-transition temperature. PMID:25463181

  17. Regional in vivo transit time measurements of aortic pulse wave velocity in mice with high-field CMR at 17.6 Tesla

    Directory of Open Access Journals (Sweden)

    Rommel Eberhard

    2010-12-01

    Full Text Available Abstract Background Transgenic mouse models are increasingly used to study the pathophysiology of human cardiovascular diseases. The aortic pulse wave velocity (PWV is an indirect measure for vascular stiffness and a marker for cardiovascular risk. Results This study presents a cardiovascular magnetic resonance (CMR transit time (TT method that allows the determination of the PWV in the descending murine aorta by analyzing blood flow waveforms. Systolic flow pulses were recorded with a temporal resolution of 1 ms applying phase velocity encoding. In a first step, the CMR method was validated by pressure waveform measurements on a pulsatile elastic vessel phantom. In a second step, the CMR method was applied to measure PWVs in a group of five eight-month-old apolipoprotein E deficient (ApoE(-/- mice and an age matched group of four C57Bl/6J mice. The ApoE(-/- group had a higher mean PWV (PWV = 3.0 ± 0.6 m/s than the C57Bl/6J group (PWV = 2.4 ± 0.4 m/s. The difference was statistically significant (p = 0.014. Conclusions The findings of this study demonstrate that high field CMR is applicable to non-invasively determine and distinguish PWVs in the arterial system of healthy and diseased groups of mice.

  18. A transit timing analysis with combined ground- and space-based photometry

    Directory of Open Access Journals (Sweden)

    Raetz St.

    2015-01-01

    The CoRoT satellite looks back on six years of high precision photometry of a very high number of stars. Thousands of transiting events are detected from which 27 were confirmed to be transiting planets so far. In my research I search and analyze TTVs in the CoRoT sample and combine the unprecedented precision of the light curves with ground-based follow-up photometry. Because CoRoT can observe transiting planets only for a maximum duration of 150 days the ground-based follow-up can help to refine the ephemeris. Here we present first examples.

  19. Robust Guaranteed Cost Observer Design for Singular Markovian Jump Time-Delay Systems with Generally Incomplete Transition Probability

    Directory of Open Access Journals (Sweden)

    Yanbo Li

    2014-01-01

    Full Text Available This paper is devoted to the investigation of the design of robust guaranteed cost observer for a class of linear singular Markovian jump time-delay systems with generally incomplete transition probability. In this singular model, each transition rate can be completely unknown or only its estimate value is known. Based on stability theory of stochastic differential equations and linear matrix inequality (LMI technique, we design an observer to ensure that, for all uncertainties, the resulting augmented system is regular, impulse free, and robust stochastically stable with the proposed guaranteed cost performance. Finally, a convex optimization problem with LMI constraints is formulated to design the suboptimal guaranteed cost filters for linear singular Markovian jump time-delay systems with generally incomplete transition probability.

  20. Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times. Use in studying the actions of cisapride in diabetic patients.

    Science.gov (United States)

    Bergmann, J F; Chassany, O; Guillausseau, P J; Bayle, M; Chagnon, S; Caulin, C; Sallenave, J R

    1992-01-01

    The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric empyting time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design. It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric empyting (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times. PMID:1425866

  1. Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca

    OpenAIRE

    Griffiths, Katharine; Rong, Hou; Wang, Hairui; Zhang, Zhihe; ZHANG, Tong; Watson, David G.; BURCHMORE, RICHARD; Loeffler, I. Kati; Kennedy, Malcolm

    2015-01-01

    Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection. Comparison of bear milks with milks of other eutherians yielded distinctive protein profiles. Proteomic and metabolomic analysis of serial milk samples collected from six giant pandas showed a prolonged transition from colostrum to main-phase lactation over a...

  2. Aggregation in environmental systems - Part 2: Catchment mean transit times and young water fractions under hydrologic nonstationarity

    Science.gov (United States)

    Kirchner, J. W.

    2016-01-01

    Methods for estimating mean transit times from chemical or isotopic tracers (such as Cl-, δ18O, or δ2H) commonly assume that catchments are stationary (i.e., time-invariant) and homogeneous. Real catchments are neither. In a companion paper, I showed that catchment mean transit times estimated from seasonal tracer cycles are highly vulnerable to aggregation error, exhibiting strong bias and large scatter in spatially heterogeneous catchments. I proposed the young water fraction, which is virtually immune to aggregation error under spatial heterogeneity, as a better measure of transit times. Here I extend this analysis by exploring how nonstationarity affects mean transit times and young water fractions estimated from seasonal tracer cycles, using benchmark tests based on a simple two-box model. The model exhibits complex nonstationary behavior, with striking volatility in tracer concentrations, young water fractions, and mean transit times, driven by rapid shifts in the mixing ratios of fluxes from the upper and lower boxes. The transit-time distribution in streamflow becomes increasingly skewed at higher discharges, with marked increases in the young water fraction and decreases in the mean water age, reflecting the increased dominance of the upper box at higher flows. This simple two-box model exhibits strong equifinality, which can be partly resolved by simple parameter transformations. However, transit times are primarily determined by residual storage, which cannot be constrained through hydrograph calibration and must instead be estimated by tracer behavior. Seasonal tracer cycles in the two-box model are very poor predictors of mean transit times, with typical errors of several hundred percent. However, the same tracer cycles predict time-averaged young water fractions (Fyw) within a few percent, even in model catchments that are both nonstationary and spatially heterogeneous (although they may be biased by roughly 0.1-0.2 at sites where strong

  3. Runoff Generation Mechanisms and Mean Transit Time in a High-Elevation Tropical Ecosystem

    Science.gov (United States)

    Mosquera, G.

    2015-12-01

    Understanding runoff generation processes in tropical mountainous regions remains poorly understood, particularly in ecosystems above the tree line. Here, we provide insights on the process dominating the ecohydrology of the tropical alpine biome (i.e., páramo) of the Zhurucay River Ecohydrological Observatory. The study site is located in south Ecuador between 3400-3900 m in elevation. We used a nested monitoring system with eight catchments (20-753 ha) to measure hydrometric data since December 2010. Biweekly samples of rainfall, streamflow, and soil water at low tension were collected for three years (May 2011-May2014) and analyzed for water stable isotopes. We conducted an isotopic characterization of rainfall, streamflow, and soil waters to investigate runoff generation. These data were also integrated into a lumped model to estimate the mean transit time (MTT) and to investigate landscape features that control its variability. The isotopic characterization evidenced that the water stored in the shallow organic horizon of the Histosol soils (Andean wetlands) located near the streams is the major contributor of water to the streams year-round, whereas the water draining through the hillslope soils, the Andosols, regulates discharge by recharging the wetlands at the valley bottoms. The MTT evaluation indicated relatively short MTTs (0.15-0.73 yr) linked to short subsurface flow paths of water. We also found evidence for topographic controls on the MTT variability. These results reveal that: 1) the ecohydrology of this ecosystem is dominated by shallow subsurface flow in the organic horizon of the soils and 2) the combination of the high storage capacity of the Andean wetlands and the slope of the catchments controls runoff generation and the high water regulation capacity of the ecosystem.

  4. Measurement of oro-caecal transit time by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Savarino, Edoardo; De Cassan, Chiara [Division of Gastroenterology, Department of Surgical, Oncological and Gastroenterological Sciences, Padua (Italy); Savarino, Vincenzo; Furnari, Manuele; Marabotto, Elisa; Gemignani, Lorenzo; Bruzzone, Luca; Moscatelli, Alessandro [University of Genoa, Division of Gastroenterology, Department of Internal Medicine, Genoa (Italy); Fox, Mark [Queen' s Medical Center, NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, Nottingham (United Kingdom); Di Leo, Giovanni [IRCCS Policlinico San Donato, Servizio di Radiologia, San Donato Milanese (Italy); Sardanelli, Francesco; Sconfienza, Luca Maria [IRCCS Policlinico San Donato, Servizio di Radiologia, San Donato Milanese (Italy); Universita degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, San Donato Milanese, Milano (Italy)

    2015-06-01

    To assess prospectively the agreement of orocaecal transit time (OCTT) measurements by lactulose hydrogen breath test (LHBT) and magnetic resonance imaging (MRI) in healthy subjects. Volunteers underwent abdominal 1.5-T MRI using axial and coronal single-shot fast-spin-echo T2-weighted sequences, having fasted and after lactulose ingestion (10 g/125 mL). Imaging and H{sub 2} excretion gas-chromatography were performed concurrently every 15 min up to 180 min. MR images were analyzed using semiautomatic segmentation to calculate small bowel gas volume (SBGV) and visually to detect bolus arrival in the caecum. Agreement between MRI- and LHBT-OCTT was assessed. Twenty-eight subjects (17 men/11 women; mean age ± standard deviation 30 ± 8 years) were evaluated. Two H{sub 2} non-producers on LHBT were excluded. OCTT measured by MRI and LHBT was concordant in 18/26 (69 %) subjects (excellent agreement, k = 0.924). Median SBGV was 49.0 mL (interquartile interval 44.1 - 51.6 mL). In 8/26 (31 %) subjects, MRI showed that the lactulose bolus was in the terminal ileum and not the caecum when H{sub 2}E increased on LHBT. Median OCTT measured by MRI was significantly longer than OCTT measured by LHBT [135 min (120 - 150 min) vs. 127.5 min (105 - 150 min); p = 0.008]. Above baseline levels, correlation between [H{sub 2}] and SBGV was significant (r = 0.964; p < 0.001). MRI provides valid measurements of OCTT and gas production in the small bowel. (orig.)

  5. Baseflow mean transit times in natural and human-altered catchments

    Science.gov (United States)

    Boll, J.; Sanchez-Murillo, R.; Brooks, E. S.; Elliot, W. E.

    2013-12-01

    Baseflow is one of the most important components of the ecosystem since it provides continuous habitat to aquatic biota; regulates water chemistry, temperature, and dissolved oxygen during summer; and functions as an essential supply for drinking water and food production worldwide. This study will evaluate baseflow mean transit times (MTTs) in five natural (i.e. pristine forest) and human-altered (i.e. agricultural, urban, and mining) catchments in eastern Washington and northern Idaho during 2011-2013. Drainage area ranges from small (6.35 km2) to meso scale (342 km2) and mean annual precipitation varies from 670 mm to 1,313 mm. MTTs were evaluated by applying d18O input precipitation and output stream waters to a lumped parameter model (FlowPC 3.2) using four main theoretical distribution models: piston flow, exponential, dispersion, and piston-exponential. Precipitation samples (N=307) were collected on weekly to biweekly basis and stream samples (N=690) were collected weekly using automated samplers. Precipitation showed a strong seasonal periodicity with a sine-wave modeled amplitude of 3.03‰ and a mean annual average of d18O= -15.13‰. Mean annual stream d18O ranged from -14.87‰ to -15.80‰ across the study catchments. Our modeling results will show information for examining solute transport and water availability under current and future land use practices and climate variability within a variety of watersheds in the inland Pacific Northwest that share similar underlying geology and climate attributes.

  6. Enhanced Diagnostic Yield with Prolonged Small Bowel Transit Time during Capsule Endoscopy

    Directory of Open Access Journals (Sweden)

    Jonathan M. Buscaglia, Sumit Kapoor, John O. Clarke, Juan Carlos Bucobo, Samuel A. Giday, Priscilla Magno, Elaine Yong, Gerard E. Mullin

    2008-01-01

    Full Text Available Background: The effect of small bowel transit time (SBTT on diagnostic yield during capsule endoscopy (CE has not been previously evaluated. Our study aim was to assess the effect of SBTT on the likelihood of detecting intestinal pathology during CE. Methods: We reviewed collected data on CE studies performed at Johns Hopkins Hospital from January 2006 to June 2007. In patients investigated for anemia or obscure bleeding, the following lesions were considered relevant: ulcers, erosions, AVMs, red spots, varices, vascular ectasias, and presence of blood. In patients with diarrhea or abdominal pain, ulcers, erosions, and blood were considered relevant. Age, gender, study indication, hospital status, and quality of bowel preparation were identified as candidate risk factors affecting SBTT. Univariate logistic and linear regression analyses were performed to study the effect of SBTT on diagnostic yield. Results: Total of 212 CE studies were analyzed; most were in outpatients (n=175, 82.9% and with excellent bowel preparation (n=177, 83.5%. Mean SBTT was 237.0min (3.9hrs. Age, gender, bowel prep, hospital status, and study indication did not significantly affect SBTT. However, increased SBTT was independently associated with increased diagnostic yield; OR=1.7 in SBTT=2-4hr (p=0.41, OR=1.8 in SBTT=4-6hrs (p=0.30, OR=9.6 in SBTT=6-8hrs (p=0.05. Conclusion: Prolonged SBTT during CE (>6 hr is associated with an increased diagnostic yield. This may be due to a positive effect on image quality during a “slower” study. The use of promotility agents may adversely affect the ability of CE to detect significant intestinal pathology.

  7. Usefulness of colon transit time and defecography in patients with chronic constipation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyoung Seuk; Chung, Jae Joon; Kim, Myung Hyun; Park, Su Mi; Yang, Hee Chul [NHIC Ilsan Hospital, Ilsan (Korea, Republic of)

    2006-05-15

    We wanted to evaluate whether both the colonic transit time (CTT) and defecography are necessary for diagnosing constipated patients, and we also wanted to assess the defecographic findings of patients with outlet obstruction on CTT. Over the recent 3 years, 26 patients (21 women and 5 men, mean age: 59 years) underwent both CTT and defecography because of their chronic constipations or defecation difficulty. The mean interval between the 2 studies was 48 days. Colonoscopy, barium enema and manometry were performed in 22, 8 and all the patients, respectively. On CTT, 13 patients (50.0%) were normal and 13 patients (50.0%) were abnormal; the abnormal results were composed of outlet obstruction (n = 8, 30.8%), outlet obstruction and colon inertia (n = 2, 7.7%), colon inertia (n = 2, 7.7%), and outlet obstruction and hindgut dysfunction (n = 1, 3.8%). On defecography, 6 patients (23.1%) were normal and 20 patients (76.9%) were abnormal; the results were composed of rectocele (n = 8, 30.7%), rectocele and perineal descent syndrome (PDS; n = 4, 15.4%), PDS and rectal intussusception (n = 3, 11.5%), spastic pelvic floor syndrome (SPFS; n = 3, 11.5%), rectocele and SPFS (n = 1, 3.8%), and rectal intussusception (n = 1, 3.8%). Of the 11 patients with outlet obstruction on CTT, rectocele (n = 4, 36.4%), SPFS (n = 1, 9.1%), rectocele and PDS (n = 1, 9.1%), and PDS and rectal intussusception (n = 1, 9.1%) were demonstrated on defecography, except for the 4 normal cases. Both CTT and defecography were necessary for diagnosing the patients with chronic constipation in compensation, and 63.6% of the patients with pelvic outlet obstruction showed an abnormal pelvic defecation function.

  8. Influence of a subsequent meal on the oro-cecal transit time of a solid test meal

    NARCIS (Netherlands)

    Priebe, MG; Wachters-Hagedoorn, RE; Landman, K; Heimweg, J; Elzinga, H; Vonk, RJ

    2006-01-01

    Oro-cecal transit time (OCTT) is determined for clinical diagnostics of intestinal complaints and research purposes. Ingestion of a subsequent meal during the test period shortens the OCTT of a liquid test meal (glucose solution), as previously reported. This study was conducted to determine whether

  9. Dating of streamwater using tritium in a post nuclear bomb pulse world: continuous variation of mean transit time with streamflow

    Directory of Open Access Journals (Sweden)

    U. Morgenstern

    2010-11-01

    Full Text Available Tritium measurements of streamwater draining the Toenepi catchment, a small dairy farming area in Waikato, New Zealand, have shown that the mean transit time of the water varies with the flow rate of the stream. Mean transit times through the catchment are 2–5 years during high baseflow conditions in winter, increasing to 30–40 years as baseflow decreases in summer, and then dramatically older water during drought conditions with mean transit time of more than 100 years. Older water is gained in the lower reaches of the stream, compared to younger water in the headwater catchment. The groundwater store supplying baseflow was estimated from the mean transit time and average baseflow to be 15.4 × 106 m3 of water, about 1 m water equivalent over the catchment and 2.3 times total annual streamflow. Nitrate is relatively high at higher flow rates in winter, but is low at times of low flow with old water. This reflects both lower nitrate loading in the catchment several decades ago as compared to current intensive dairy farming, and denitrification processes occurring in the older groundwater. Silica, leached from the aquifer material and accumulating in the water in proportion to contact time, is high at times of low streamflow with old water. There was a good correlation between silica concentration and streamwater age, which potentially allows silica concentrations to be used as a proxy for age when calibrated by tritium measurements. This study shows that tritium dating of stream water is possible with single tritium measurements now that bomb-test tritium has effectively disappeared from hydrological systems in New Zealand, without the need for time-series data.

  10. A Capacity-Restraint Transit Assignment Model When a Predetermination Method Indicates the Invalidity of Time Independence

    Directory of Open Access Journals (Sweden)

    Haoyang Ding

    2015-01-01

    Full Text Available The statistical independence of time of every two adjacent bus links plays a crucial role in deciding the feasibility of using many mathematical models to analyze urban transit networks. Traditional research generally ignores the time independence that acts as the ground of their models. Assumption is usually made that time independence of every two adjacent links is sound. This is, however, actually groundless and probably causes problematic conclusions reached by corresponding models. Many transit assignment models such as multinomial probit-based models lose their effects when the time independence is not valid. In this paper, a simple method to predetermine the time independence is proposed. Based on the predetermination method, a modified capacity-restraint transit assignment method aimed at engineering practice is put forward and tested through a small contrived network and a case study in Nanjing city, China, respectively. It is found that the slope of regression equation between the mean and standard deviation of normal distribution acts as the indicator of time independence at the same time. Besides, our modified assignment method performs better than the traditional one with more reasonable results while keeping the property of simplicity well.

  11. Estimating subsurface water volumes and transit times in Hokkaido river catchments, Japan, using high-accuracy tritium analysis

    Science.gov (United States)

    Gusyev, Maksym; Yamazaki, Yusuke; Morgenstern, Uwe; Stewart, Mike; Kashiwaya, Kazuhisa; Hirai, Yasuyuki; Kuribayashi, Daisuke; Sawano, Hisaya

    2015-04-01

    The goal of this study is to estimate subsurface water transit times and volumes in headwater catchments of Hokkaido, Japan, using the New Zealand high-accuracy tritium analysis technique. Transit time provides insights into the subsurface water storage and therefore provides a robust and quick approach to quantifying the subsurface groundwater volume. Our method is based on tritium measurements in river water. Tritium is a component of meteoric water, decays with a half-life of 12.32 years, and is inert in the subsurface after the water enters the groundwater system. Therefore, tritium is ideally suited for characterization of the catchment's responses and can provide information on mean water transit times up to 200 years. Only in recent years has it become possible to use tritium for dating of stream and river water, due to the fading impact of the bomb-tritium from thermo-nuclear weapons testing, and due to improved measurement accuracy for the extremely low natural tritium concentrations. Transit time of the water discharge is one of the most crucial parameters for understanding the response of catchments and estimating subsurface water volume. While many tritium transit time studies have been conducted in New Zealand, only a limited number of tritium studies have been conducted in Japan. In addition, the meteorological, orographic and geological conditions of Hokkaido Island are similar to those in parts of New Zealand, allowing for comparison between these regions. In 2014, three field trips were conducted in Hokkaido in June, July and October to sample river water at river gauging stations operated by the Ministry of Land, Infrastructure, Transport and Tourism (MLIT). These stations have altitudes between 36 m and 860 m MSL and drainage areas between 45 and 377 km2. Each sampled point is located upstream of MLIT dams, with hourly measurements of precipitation and river water levels enabling us to distinguish between the snow melt and baseflow contributions

  12. Simulations of time harmonic blood flow in the Mesenteric artery: comparing finite element and lattice Boltzmann methods

    Directory of Open Access Journals (Sweden)

    Hose Rod

    2009-10-01

    Full Text Available Abstract Background Systolic blood flow has been simulated in the abdominal aorta and the superior mesenteric artery. The simulations were carried out using two different computational hemodynamic methods: the finite element method to solve the Navier Stokes equations and the lattice Boltzmann method. Results We have validated the lattice Boltzmann method for systolic flows by comparing the velocity and pressure profiles of simulated blood flow between methods. We have also analyzed flow-specific characteristics such as the formation of a vortex at curvatures and traces of flow. Conclusion The lattice Boltzmann Method is as accurate as a Navier Stokes solver for computing complex blood flows. As such it is a good alternative for computational hemodynamics, certainly in situation where coupling to other models is required.

  13. Incidence and severity of coronary artery disease in patients with atrial fibrillation undergoing first-time coronary angiography.

    Directory of Open Access Journals (Sweden)

    Stefan Kralev

    Full Text Available BACKGROUND: In standard reference sources, the incidence of coronary artery disease (CAD in patients with atrial fibrillation (AF ranged between 24 and 46.5%. Since then, the incidence of cardiovascular risk factors (CRF has increased and modern treatment strategies ("pill in the pocket" are only applicable to patients without structural heart disease. The aim of this study was to investigate the incidence and severity of CAD in patients with AF. METHODS: From January 2005 until December 2009, we included 261 consecutive patients admitted to hospital with paroxysmal, persistent or permanent AF in this prospective study. All patients underwent coronary angiography and the Framingham risk score (FRS was calculated. Patients with previously diagnosed or previously excluded CAD were excluded. RESULTS: The overall incidence of CAD in patients presenting with AF was 34%; in patients >70 years, the incidence of CAD was 41%. The incidence of patients undergoing a percutaneous coronary intervention (PCI or coronary artery bypass graft (CABG was 21%. Patients with CAD were older (73±8 years vs 68±10 years, p = 0.001, had significantly more frequent hypercholesterolemia (60% vs 30%, p<0.001, were more frequent smokers (26% vs 13%, p = 0.017 and suffered from angina more often (37% vs 2%, p<0.001. There was a significant linear trend among the FRS categories in percentage and the prevalence of CAD and PCI/CABG (p<0.0001. CONCLUSIONS: The overall incidence of CAD in patients presenting with AF was relatively high at 34%; the incidence of PCI/CABG was 21%. Based upon increasing CRF in the western world, we recommend a careful investigation respecting the FRS to either definitely exclude or establish an early diagnosis of CAD--which could contribute to an early and safe therapeutic strategy considering type Ic antiarrhythmics and oral anticoagulation.

  14. MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection.

    Science.gov (United States)

    Nguyen, Hai V; Gore, Jesse; Zhong, Xin; Savant, Sudha S; Deitz-McElyea, Samantha; Schmidt, C Max; House, Michael G; Korc, Murray

    2016-10-01

    Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR. Expression was correlated with disease recurrence, recurrence-free survival (RFS), and overall survival (OS). Station 8 lymph nodes from 37 patients (30 periampullary carcinomas (PCs), 2 chronic pancreatitis, 5 other cancers) exhibited increased miRNA-10b levels in 14/30 PCs, and in 10 of these 14 patients, cancer recurred during the study period (2012-2015). High miRNA-10b was also associated with shorter RFS (42.5 vs. 92.4 weeks, p < 0.05) but not OS, whereas miRNA-30c, miRNA-21, and miRNA-155 levels and CK19 mRNA levels in station 8 nodes were variable and did not correlate with RFS or OS. We conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors.

  15. Groundwater age, life expectancy and transit time distributions in advective-dispersive systems: 1. Generalized reservoir theory

    CERN Document Server

    Cornaton, F; 10.1016/j.advwatres.2005.10.009

    2011-01-01

    We present a methodology for determining reservoir groundwater age and transit time probability distributions in a deterministic manner, considering advective-dispersive transport in steady velocity fields. In a first step, we propose to model the statistical distribution of groundwater age at aquifer scale by means of the classical advection-dispersion equation for a conservative and nonreactive tracer, associated to proper boundary conditions. The evaluated function corresponds to the density of probability of the random variable age, age being defined as the time elapsed since the water particles entered the aquifer. An adjoint backward model is introduced to characterize the life expectancy distribution, life expectancy being the time remaining before leaving the aquifer. By convolution of these two distributions, groundwater transit time distributions, from inlet to outlet, are fully defined for the entire aquifer domain. In a second step, an accurate and efficient method is introduced to simulate the tr...

  16. Nonlinearities and transit times in soil organic matter models: new developments in the SoilR package

    Science.gov (United States)

    Sierra, Carlos; Müller, Markus

    2016-04-01

    SoilR is an R package for implementing diverse models representing soil organic matter dynamics. In previous releases of this package, we presented the implementation of linear first-order models with any number of pools as well as radiocarbon dynamics. We present here new improvements of the package regarding the possibility to implement models with nonlinear interactions among state variables and the possibility to calculate ages and transit times for nonlinear models with time dependencies. We show here examples on how to implement model structures with Michaelis-Menten terms for explicit microbial growth and resource use efficiency, and Langmuir isotherms for representing adsorption of organic matter to mineral surfaces. These nonlinear terms can be implemented for any number of organic matter pools, microbial functional groups, or mineralogy, depending on user's requirements. Through a simple example, we also show how transit times of organic matter in soils are controlled by the time-dependencies of the input terms.

  17. Molecular Dynamics at Electrical- and Optical-Driven Phase Transitions: Time-Resolved Infrared Studies Using Fourier-Transform Spectrometers

    Science.gov (United States)

    Peterseim, Tobias; Dressel, Martin

    2016-06-01

    The time-dependent optical properties of molecular systems are investigated by step-scan Fourier-transform spectroscopy in order to explore the dynamics at phase transitions and molecular orientation in the milli- and microsecond range. The electrical switching of liquid crystals traced by vibrational spectroscopy reveals a rotation of the molecules with a relaxation time of 2 ms. The photo-induced neutral-ionic transition in TTF-CA takes place by a suppression of the dimerization in the ionic phase and creation of neutral domains. The time-dependent infrared spectra, employed to investigate the domain-wall dynamics, depend on temperature and laser pulse intensity; the relaxation of the spectra follows a stretched-exponential decay with relaxation times in the microsecond range strongly dependent on temperature and laser intensity. We present all details of the experimental setups and thoroughly discuss the technical challenges.

  18. [Reseach on THz Time Domain Spectrum of Photo-Induced Insulator-Metal Phase Transition of VO₂ Films].

    Science.gov (United States)

    Wang, Chang-lei; Wu, Shuai; Li, Yan-feng; Liu, Bo-wen; Hu, Ming-lie; Chai, Lu; Xing, Qi-rong; Wang, Qing-yue

    2015-11-01

    Vanadium dioxide (VO₂) film will be phase-transitioned from insulator into metal, accompanied with dramatic change on conductivity, which is named as photo-induced insulator-metal phase transition. Such phase transition of VO₂ film has important application potentials in modulators or other functional devices for terahertz waves. In this paper, the transmission spectrum variations before and after the photo-induced insulator-metal phase transition of vanadium dioxide film are investigated, and the phase transition properties in terahertz(THz) region are analyzed. In the experiment, the phase transition of the VO₂ film was induced by a continuous wave (CW) laser source and a femtosecond (fs) laser source, respectively. Obvious changes on the THz waveforms were observed for the both mentioned means of excitation, and the amplitude attenuation, as well as the signal distortion, was intensified with the increase of the impinging optical power. The fast Fourier transform (FFT) spectra of the transmitted THz time-domain signals were analyzed and it was found that the amplitude of the transmitted spectrum decreased synchronously with the increase of the optical power, accompanied with deformation of the spectrum line shape at the same time. The reason was that the macroscopic dielectric properties of the VO₂ film approached gradually to that of a metal as laser power was increased. A parameter, transmission modulation function, was defined in the paper as the amplitude difference between the transmission spectra of the VO₂ film before and after the laser excitation, to describe the dispersivity of the photo-induced phase transition more clearly. From the curve of the transmission modulation function, strong frequency-dependent properties at THz frequencies were found to vary regularly with the incident light power. After furthermore comparison, it was found that, though the insulator-metal phase transition could be trigged by both CW laser source and fs laser

  19. Radiofrequency ablation in a porcine liver model: Effects of transcatheter arterial embolization with iodized oil on ablation time, maximum output, and coagulation diameter as well as angiographic characteristics

    Institute of Scientific and Technical Information of China (English)

    Motoki Nakai; Morio Sato; Shinya Sahara; Nobuyuki Kawai; Hirohiko Tanihata; Masashi Kimura; Masaki Terada

    2007-01-01

    AIM:To evaluate the effects of combined radiofrequency ablation and transcatheter arterial embolization with iodized oil on ablation time, maximum output, coagulation diameter, and portal angiography in a porcine liver model.METHODS: Radiofrequency ablation (RFA) was applied to in vivo livers of 10 normal pigs using a 17-gauge 3.0cm expandable LeVeen RF needle electrode with or without transcatheter arterial embolization (TAE) with iodized oil (n = 5). In each animal, 2 areas in the liver were ablated. Direct portography was performed before and after RFA. Ablation was initiated at an output of 30 W, and continued with an increase of 10 W per minute until rolloff occurred. Ablation time and maximum output until roll-off, and coagulated tissue diameter were compared between the 2 groups. Angiographic changes on portography before and after ablation were also reviewed.RESULTS: For groups with and without TAE with iodized oil, the ablation times until roll-off were 320.6 ± 30.9seconds and 445.1 ± 35.9 seconds, respectively, maximum outputs were 69.0 ± 7.38 W and 87.0 ± 4.83 Wand maximal diameters of coagulation were 41.7 ± 3.85mm and 33.2 ± 2.28 mm. Significant reductions of ablation time and maximum output, and significantly largercoagulation diameter were obtained with RFA following TAE with iodized oil compared to RFA alone. Portography after RFA following TAE with iodized oil revealed more occlusion of the larger portal branches than with RFA alone.CONCLUSION: RFA following TAE with iodized oil can increase the volume of coagulation necrosis with lower output and shorter ablation time than RFA alone in normal pig liver tissue.

  20. Intraoperative hemodynamic evaluation of the radial and ulnar arteries during free radial forearm flap procedure.

    Science.gov (United States)

    Lorenzetti, Fulvio; Giordano, Salvatore; Suominen, Erkki; Asko-Seljavaara, Sirpa; Suominen, Sinikka

    2010-02-01

    The purpose of this prospective study was to assess the blood flow of the radial and ulnar arteries before and after radial forearm flap raising. Twenty-two patients underwent radial forearm microvascular reconstruction for leg soft tissue defects. Blood flow of the radial, ulnar, and recipient arteries was measured intraoperatively by transit-time and ultrasonic flowmeter. In the in situ radial artery, the mean blood flow was 60.5 +/- 47.7 mL/min before, 6.7 +/- 4.1 mL/min after raising the flap, and 5.8 +/- 2.0 mL/min after end-to-end anastomosis to the recipient artery. In the ulnar artery, the mean blood flow was 60.5 +/- 43.3 mL/min before harvesting the radial forearm flap and significantly increased to 85.7 +/- 57.9 mL/min after radial artery sacrifice. A significant difference was also found between this value and the value of blood flow in the ulnar and radial arteries pooled together ( P < 0.05). The vascular resistance in the ulnar artery decreased significantly after the radial artery flap raising (from 2.7 +/- 3.1 to 1.9 +/- 2.2 peripheral resistance units, P = 0.010). The forearm has a conspicuous arterial vascularization not only through the radial and ulnar arteries but also through the interosseous system. The raising of the radial forearm flap increases blood flow and decreases vascular resistance in the ulnar artery. PMID:19902406

  1. Local and global synchronization transitions induced by time delays in small-world neuronal networks with chemical synapses.

    Science.gov (United States)

    Yu, Haitao; Wang, Jiang; Du, Jiwei; Deng, Bin; Wei, Xile

    2015-02-01

    Effects of time delay on the local and global synchronization in small-world neuronal networks with chemical synapses are investigated in this paper. Numerical results show that, for both excitatory and inhibitory coupling types, the information transmission delay can always induce synchronization transitions of spiking neurons in small-world networks. In particular, regions of in-phase and out-of-phase synchronization of connected neurons emerge intermittently as the synaptic delay increases. For excitatory coupling, all transitions to spiking synchronization occur approximately at integer multiples of the firing period of individual neurons; while for inhibitory coupling, these transitions appear at the odd multiples of the half of the firing period of neurons. More importantly, the local synchronization transition is more profound than the global synchronization transition, depending on the type of coupling synapse. For excitatory synapses, the local in-phase synchronization observed for some values of the delay also occur at a global scale; while for inhibitory ones, this synchronization, observed at the local scale, disappears at a global scale. Furthermore, the small-world structure can also affect the phase synchronization of neuronal networks. It is demonstrated that increasing the rewiring probability can always improve the global synchronization of neuronal activity, but has little effect on the local synchronization of neighboring neurons.

  2. On the use of spring baseflow recession for a more accurate parameterization of aquifer transit time distribution functions

    Directory of Open Access Journals (Sweden)

    J. Farlin

    2013-05-01

    Full Text Available Baseflow recession analysis and groundwater dating have up to now developed as two distinct branches of hydrogeology and have been used to solve entirely different problems. We show that by combining two classical models, namely the Boussinesq equation describing spring baseflow recession, and the exponential piston-flow model used in groundwater dating studies, the parameters describing the transit time distribution of an aquifer can be in some cases estimated to a far more accurate degree than with the latter alone. Under the assumption that the aquifer basis is sub-horizontal, the mean transit time of water in the saturated zone can be estimated from spring baseflow recession. This provides an independent estimate of groundwater transit time that can refine those obtained from tritium measurements. The approach is illustrated in a case study predicting atrazine concentration trend in a series of springs draining the fractured-rock aquifer known as the Luxembourg Sandstone. A transport model calibrated on tritium measurements alone predicted different times to trend reversal following the nationwide ban on atrazine in 2005 with different rates of decrease. For some of the springs, the actual time of trend reversal and the rate of change agreed extremely well with the model calibrated using both tritium measurements and the recession of spring discharge during the dry season. The agreement between predicted and observed values was however poorer for the springs displaying the most gentle recessions, possibly indicating a stronger influence of continuous groundwater recharge during the summer months.

  3. Validity of computational hemodynamics in human arteries based on 3D time-of-flight MR angiography and 2D electrocardiogram gated phase contrast images

    Science.gov (United States)

    Yu, Huidan (Whitney); Chen, Xi; Chen, Rou; Wang, Zhiqiang; Lin, Chen; Kralik, Stephen; Zhao, Ye

    2015-11-01

    In this work, we demonstrate the validity of 4-D patient-specific computational hemodynamics (PSCH) based on 3-D time-of-flight (TOF) MR angiography (MRA) and 2-D electrocardiogram (ECG) gated phase contrast (PC) images. The mesoscale lattice Boltzmann method (LBM) is employed to segment morphological arterial geometry from TOF MRA, to extract velocity profiles from ECG PC images, and to simulate fluid dynamics on a unified GPU accelerated computational platform. Two healthy volunteers are recruited to participate in the study. For each volunteer, a 3-D high resolution TOF MRA image and 10 2-D ECG gated PC images are acquired to provide the morphological geometry and the time-varying flow velocity profiles for necessary inputs of the PSCH. Validation results will be presented through comparisons of LBM vs. 4D Flow Software for flow rates and LBM simulation vs. MRA measurement for blood flow velocity maps. Indiana University Health (IUH) Values Fund.

  4. Psychosocial Functioning Problems over Time among High-Risk Youths: A Latent Class Transition Analysis

    Science.gov (United States)

    Dembo, Richard; Wareham, Jennifer; Poythress, Norman; Meyers, Kathleen; Schmeidler, James

    2008-01-01

    The authors report the results of latent class analyses and latent class transition analyses of antisocial behavior risk factors among 137 youths participating in a juvenile diversion program. The study examined the youths' latent classifications using baseline and 1-year follow-up measures of family, peer, education, and mental health risk…

  5. Comparison of the Number of Image Acquisitions and Procedural Time Required for Trans arterial Chemo embolization of Hepatocellular Carcinoma with and without Tumor-Feeder Detection Software

    International Nuclear Information System (INIS)

    To compare the number of image acquisitions and procedural time required for trans arterial chemo embolization (TACE) with and without tumor-feeder detection software in cases of hepatocellular carcinoma (HCC). Materials and Methods. We retrospectively reviewed 50 cases involving software-assisted TACE (September 2011-February 2013) and 84 cases involving TACE without software assistance (January 2010-August 2011). We compared the number of image acquisitions, the overall procedural time, and the therapeutic efficacy in both groups. Results. Angiography acquisition per session reduced from 6.6 times to 4.6 times with software assistance ( Ρ < 0.001 ). Total image acquisition significantly decreased from 10.4 times to 8.7 times with software usage ( Ρ = 0.004 ). The mean procedural time required for a single session with software-assisted TACE (103 min) was significantly lower than that for a session without software (116 min, Ρ = 0.021 ). For TACE with and without software usage, the complete (68% versus 63%, resp.) and objective (78% versus 80%, resp.) response rates did not differ significantly. Conclusion. In comparison with software-unassisted TACE, automated feeder-vessel detection software-assisted TACE for HCC involved fewer image acquisitions and could be completed faster while maintaining a comparable treatment response

  6. Real-time origin-destination matrices estimation for urban rail transit network based on structural state-space model

    Institute of Scientific and Technical Information of China (English)

    姚向明; 赵鹏; 禹丹丹

    2015-01-01

    The major objective of this work was to establish a structural state-space model to estimate the dynamic origin-destination(O-D) matrices for urban rail transit network, using in- and out-flows at each station from automatic fare collection(AFC) system as the real time observed passenger flow counts. For lacking of measurable passenger flow information, the proposed model employs priori O-D matrices and travel time distribution from historical travel records in AFC system to establish the dynamic system equations. An arriving rate based on travel time distribution is defined to identify the dynamic interrelations between time-varying O-D flows and observed flows, which greatly decreases the computational complexity and improve the model’s applicability for large-scale network. This methodology is tested in a real transit network from Beijing subway network in China through comparing the predicted matrices with the true matrices. Case study results indicate that the proposed model is effective and applicative for estimating dynamic O-D matrices for large-scale rail transit network.

  7. Real-time origin-destination matrices estimation for urban rail transit network based on structural state-space model

    Institute of Scientific and Technical Information of China (English)

    姚向明; 赵鹏; 禹丹丹

    2015-01-01

    The major objective of this work was to establish a structural state-space model to estimate the dynamic origin-destination (O-D) matrices for urban rail transit network, using in- and out-flows at each station from automatic fare collection (AFC) system as the real time observed passenger flow counts. For lacking of measurable passenger flow information, the proposed model employs priori O-D matrices and travel time distribution from historical travel records in AFC system to establish the dynamic system equations. An arriving rate based on travel time distribution is defined to identify the dynamic interrelations between time-varying O-D flows and observed flows, which greatly decreases the computational complexity and improve the model’s applicability for large-scale network. This methodology is tested in a real transit network from Beijing subway network in China through comparing the predicted matrices with the true matrices. Case study results indicate that the proposed model is effective and applicative for estimating dynamic O-D matrices for large-scale rail transit network.

  8. A Numerical Scheme for Ordinary Differential Equations Having Time Varying and Nonlinear Coefficients Based on the State Transition Matrix

    Science.gov (United States)

    Bartels, Robert E.

    2002-01-01

    A variable order method of integrating initial value ordinary differential equations that is based on the state transition matrix has been developed. The method has been evaluated for linear time variant and nonlinear systems of equations. While it is more complex than most other methods, it produces exact solutions at arbitrary time step size when the time variation of the system can be modeled exactly by a polynomial. Solutions to several nonlinear problems exhibiting chaotic behavior have been computed. Accuracy of the method has been demonstrated by comparison with an exact solution and with solutions obtained by established methods.

  9. Finite-Time Boundedness for a Class of Delayed Markovian Jumping Neural Networks with Partly Unknown Transition Probabilities

    Directory of Open Access Journals (Sweden)

    Li Liang

    2014-01-01

    Full Text Available This paper is concerned with the problem of finite-time boundedness for a class of delayed Markovian jumping neural networks with partly unknown transition probabilities. By introducing the appropriate stochastic Lyapunov-Krasovskii functional and the concept of stochastically finite-time stochastic boundedness for Markovian jumping neural networks, a new method is proposed to guarantee that the state trajectory remains in a bounded region of the state space over a prespecified finite-time interval. Finally, numerical examples are given to illustrate the effectiveness and reduced conservativeness of the proposed results.

  10. Comparison of transient arterial occlusion and muscle exercise provocation for assessment of perfusion reserve in skeletal muscle with real-time contrast-enhanced ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Krix, Martin, E-mail: martin.krix@kabelbw.de [German Cancer Research Center, Research Program Imaging and Radiooncology, Department of Radiology, INF 280, D-69120 Heidelberg (Germany); Bracco Imaging Germany, Max-Stromeyer-Str. 116, D-78467 Konstanz (Germany); Krakowski-Roosen, Holger [German Cancer Research Center, Department of Translational Oncology, INF 280, D-69120 Heidelberg (Germany); Armarteifio, Erick [University Hospital of Heidelberg, Department of Diagnostic and Interventional Radiology, INF 110, D-69120 Heidelberg (Germany); Fuerstenberger, Susanne [University Hospital of Heidelberg, Department of Vascular Surgery, INF 110, D-69120 Heidelberg (Germany); Delorme, Stefan [German Cancer Research Center, Research Program Imaging and Radiooncology, Department of Radiology, INF 280, D-69120 Heidelberg (Germany); Kauczor, Hans-Ulrich; Weber, Marc-Andre [University Hospital of Heidelberg, Department of Diagnostic and Interventional Radiology, INF 110, D-69120 Heidelberg (Germany)

    2011-06-15

    Objective: Contrast-enhanced ultrasound (CEUS) is able to quantify muscle perfusion and changes in perfusion due to muscle exercise in real-time. However, reliable measurement of standardized muscle exercise is difficult to perform in clinical examinations. We compared perfusion reserve assessed by CEUS after transient arterial occlusion and exercise to find the most suitable measurement for clinical application. Methods: Contrast pulse sequencing (7 MHz) during continuous IV infusion of SonoVue (4.8 mL/300 s) was used in 8 healthy volunteers to monitor muscle perfusion of the gastrocnemius muscle during transient (1 min) arterial occlusion produced by a thigh cuff of a venous occlusion plethysmograph. Isometric muscle exercise (50% of individual maximum strength for 20 s) was subsequently performed during the same examination, and several CEUS parameters obtained from ultrasound-signal-intensity-time curves and its calculation errors were compared. Results: The mean maximum local blood volume after occlusion was 13.9 [{approx}mL] (range, 4.5-28.8 [{approx}mL]), and similar values were measured after sub-maximum exercise 13.8 [{approx}mL], (range, 4.6-22.2 [{approx}mL]. The areas under the curve during reperfusion vs. recovery were also similar (515.2 {+-} 257.5 compared to 482.2 {+-} 187.5 [{approx}mL s]) with a strong correlation (r = 0.65), as were the times to maximum (15.3 s vs. 15.9 s), with a significantly smaller variation for the occlusion method ({+-}2.1 s vs. {+-}9.0 s, p = 0.03). The mean errors for all calculated CEUS parameters were lower for the occlusion method than for the exercise test. Conclusions: CEUS muscle perfusion measurements can be easily performed after transient arterial occlusion. It delivers data which are comparable to CEUS measurements after muscle exercise but with a higher robustness. This method can be easily applied in clinical examination of patients with e.g. PAOD or diabetic microvessel diseases to assess perfusion reserve.

  11. Comparison of transient arterial occlusion and muscle exercise provocation for assessment of perfusion reserve in skeletal muscle with real-time contrast-enhanced ultrasound

    International Nuclear Information System (INIS)

    Objective: Contrast-enhanced ultrasound (CEUS) is able to quantify muscle perfusion and changes in perfusion due to muscle exercise in real-time. However, reliable measurement of standardized muscle exercise is difficult to perform in clinical examinations. We compared perfusion reserve assessed by CEUS after transient arterial occlusion and exercise to find the most suitable measurement for clinical application. Methods: Contrast pulse sequencing (7 MHz) during continuous IV infusion of SonoVue (4.8 mL/300 s) was used in 8 healthy volunteers to monitor muscle perfusion of the gastrocnemius muscle during transient (1 min) arterial occlusion produced by a thigh cuff of a venous occlusion plethysmograph. Isometric muscle exercise (50% of individual maximum strength for 20 s) was subsequently performed during the same examination, and several CEUS parameters obtained from ultrasound-signal-intensity-time curves and its calculation errors were compared. Results: The mean maximum local blood volume after occlusion was 13.9 [∼mL] (range, 4.5-28.8 [∼mL]), and similar values were measured after sub-maximum exercise 13.8 [∼mL], (range, 4.6-22.2 [∼mL]. The areas under the curve during reperfusion vs. recovery were also similar (515.2 ± 257.5 compared to 482.2 ± 187.5 [∼mL s]) with a strong correlation (r = 0.65), as were the times to maximum (15.3 s vs. 15.9 s), with a significantly smaller variation for the occlusion method (±2.1 s vs. ±9.0 s, p = 0.03). The mean errors for all calculated CEUS parameters were lower for the occlusion method than for the exercise test. Conclusions: CEUS muscle perfusion measurements can be easily performed after transient arterial occlusion. It delivers data which are comparable to CEUS measurements after muscle exercise but with a higher robustness. This method can be easily applied in clinical examination of patients with e.g. PAOD or diabetic microvessel diseases to assess perfusion reserve.

  12. Time-resolved studies of phase transition dynamics in strongly correlated manganites

    Energy Technology Data Exchange (ETDEWEB)

    Rini, M; Zhu, Y; Schoenlein, R W [Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Tobey, R; Dean, N; Wall, S; Ehrke, H [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford (United Kingdom); Tomioka, Y; Tokura, Y [Correlated Electron Research Center, AIST Tsukuba Central 4, Tsukuba (Japan); Cavalleri, A, E-mail: mrini@lbl.go [Max Planck Group for Structural Dynamics, Centre for Free Electron Laser Science and Department of Physics, University of Hamburg, Hamburg (Germany)

    2009-02-01

    Ultrafast light pulses can be used to control electronic, magnetic and structural phases of complex solids. Here, we investigate the dynamics of insulator-metal phase transitions in colossal magnetoresistive (CMR) manganites by a combination of femtosecond visible-to-midinfrared pump-probe techniques and transport measurements. We show that an insulator-metal transition can be stimulated in CMR manganites by both above bandgap excitation and selective excitation of individual vibrational degrees of freedom. These two approaches rely on the ultrafast manipulation of parameters controlling the electronic filling and the electronic bandwidth respectively, extending the concepts of filling and bandwidth control to the ultrafast timescale. The ultrafast vibrational control of correlated-electron phases may provide new insights into the role played by lattice vibrations in determining the electronic properties of complex solids.

  13. Time-resolved Studies of Phase Transition Dynamics in Strongly Correlated Manganites

    Energy Technology Data Exchange (ETDEWEB)

    Rini, M; Tobey, R; Dean, N; Wall, S; Ehrke, H; Zhu, Y; Tomioka, Y; Tokura, Y; Schoenlein, R W; Cavalleri, A

    2008-12-05

    Ultrafast light pulses can be used to control electronic, magnetic and structural phases of complex solids. Here, we investigate the dynamics of insulator-metal phase transitions in colossal magnetoresistive (CMR) manganites by a combination of femtosecond visible-to-midinfrared pump-probe techniques and transport measurements. We show that an insulator-metal transition can be stimulated in CMR manganites by both above bandgap excitation and selective excitation of individual vibrational degrees of freedom. These two approaches rely on the ultrafast manipulation of parameters controlling the electronic filling and the electronic bandwidth respectively, extending the concepts of filling and bandwidth control to the ultrafast timescale. The ultrafast vibrational control of correlated-electron phases may provide new insights into the role played by lattice vibrations in determining the electronic properties of complex solids.

  14. Transitions between child and adult mental health services: service design, philosophy and meaning at uncertain times.

    Science.gov (United States)

    Murcott, W J

    2014-09-01

    A young person's transition of care from child and adolescent mental health services to adult mental health services can be an uncertain and distressing event that can have serious ramifications for their recovery. Recognition of this across many countries and recent UK media interest in the dangers of mental health services failing young people has led practitioners to question the existing processes. This paper reviews the current theories and research into potential failings of services and encourages exploration for a deeper understanding of when and how care should be managed in the transition process for young people. Mental health nurses can play a vital role in this process and, by adopting the assumptions of this paradigm, look at transition from this unique perspective. By reviewing the current ideas related to age boundaries, service thresholds, service philosophy and service design, it is argued that the importance of the therapeutic relationship, the understanding of the cultural context of the young person and the placing of the young person in a position of autonomy and control should be central to any decision and process of transfer between two mental health services.

  15. Changes in regional cerebral hemodynamics and its significance after internal carotid artery stenting in patients with moderate/severe internal carotid artery stenosis

    Directory of Open Access Journals (Sweden)

    Jia-chuan YAN

    2011-08-01

    Full Text Available Objective To evaluate the cerebral hemodynamic changes before and after carotid artery angioplasty and stenting.Methods Thirty-eight patients with moderate/severe internal carotid artery stenosis underwent carotid artery angioplasty and stenting.CT perfusion imaging was performed pre-and post-surgery to determine the cerebral blood flow(CBF,cerebral blood volume(CBV and mean transit time(MTT in the ipsilateral and contralateral cerebrum.Results Before angioplasty and stenting,the CBF and CBV decreased,and MTT increased in the ipsilateral cerebrum than in contralateral cerebrum.After intervention,the CBF and CBV increased and CTT shortened obviously in comparison with that of pre-surgery(P 0.05.Conclusion Angioplasty and stenting may improve the cerebral hemodynamics of patients with severe/moderate internal carotid artery stenosis.

  16. Radiographic-anatomical aspects and gastrointestinal transit time in the spectacled caiman Caiman crocodilus crocodilus (Linnaeus, 1758) (Crocodylia, Alligatoridae)

    OpenAIRE

    Heloisa Castro Pereira; Juliana Macedo Magnino Silva; Líria Queiroz Luz Hirano; Luiz Martins da Silva Junior; André Luiz Quagliatto Santos

    2014-01-01

    In Brazil, there is increasing interest in the establishment of captive breeding programs for caiman. However, there is a paucity of in-depth studies on the proper care of these reptiles in captivity, particularly regarding optimal food type and frequency of feeding. The purpose of this study was to determine radiographic-anatomical aspects of, and gastrointestinal transit time of Caiman crocodilus crocodilus using contrast radiography. Ten caiman were used in the study, five males and five f...

  17. Transit Riders’ Perception of Waiting Time and Stops’ Surrounding Environments

    OpenAIRE

    Marina Lagune-Reutler; Andrew Guthrie; Yingling Fan; David Levinson

    2015-01-01

    Reducing the burden of waiting in transit travel is critical to increase the attractiveness of public transportation and encourage people’s shift from automobile mode. Research shows that wait time perception is highly subjective and varies according to various factors such as mode, availability of schedule information or stops amenities. In addition, high-quality environments are known to reduce stress and to encourage walking and biking. Nevertheless, little research exists on the influen...

  18. Detailed Analysis of Configuration Interaction and Calculation of Radiative Transition Rates in Seven Times Ionized Tungsten (W VIII)

    OpenAIRE

    Jérôme Deprince; Pascal Quinet

    2015-01-01

    A new set of oscillator strengths and transition probabilities for EUV spectral lines of seven times ionized tungsten (W VIII) is reported in the present paper. These results have been obtained using the pseudo-relativistic Hartree-Fock (HFR) method combined with a semi-empirical optimization of the radial parameters minimizing the discrepancies between computed energy levels and available experimental data. The final physical model considered in the calculations has been chosen further to a ...

  19. Semi-automatic detection of Gd-DTPA-saline filled capsules for colonic transit time assessment in MRI

    Science.gov (United States)

    Harrer, Christian; Kirchhoff, Sonja; Keil, Andreas; Kirchhoff, Chlodwig; Mussack, Thomas; Lienemann, Andreas; Reiser, Maximilian; Navab, Nassir

    2008-03-01

    Functional gastrointestinal disorders result in a significant number of consultations in primary care facilities. Chronic constipation and diarrhea are regarded as two of the most common diseases affecting between 2% and 27% of the population in western countries 1-3. Defecatory disorders are most commonly due to dysfunction of the pelvic floor or the anal sphincter. Although an exact differentiation of these pathologies is essential for adequate therapy, diagnosis is still only based on a clinical evaluation1. Regarding quantification of constipation only the ingestion of radio-opaque markers or radioactive isotopes and the consecutive assessment of colonic transit time using X-ray or scintigraphy, respectively, has been feasible in clinical settings 4-8. However, these approaches have several drawbacks such as involving rather inconvenient, time consuming examinations and exposing the patient to ionizing radiation. Therefore, conventional assessment of colonic transit time has not been widely used. Most recently a new technique for the assessment of colonic transit time using MRI and MR-contrast media filled capsules has been introduced 9. However, due to numerous examination dates per patient and corresponding datasets with many images, the evaluation of the image data is relatively time-consuming. The aim of our study was to develop a computer tool to facilitate the detection of the capsules in MRI datasets and thus to shorten the evaluation time. We present a semi-automatic tool which provides an intensity, size 10, and shape-based 11,12 detection of ingested Gd-DTPA-saline filled capsules. After an automatic pre-classification, radiologists may easily correct the results using the application-specific user interface, therefore decreasing the evaluation time significantly.

  20. Detecting Relic Gravitational Waves by Pulsar Timing Arrays: Effects of Cosmic Phase Transitions and Relativistic Free-Streaming Gases

    CERN Document Server

    Liu, Xiao-Jin; Zhang, Yang; Zhu, Zong-Hong

    2016-01-01

    Relic gravitational waves (RGWs) generated in the early Universe form a stochastic GW background, which can be directly probed by measuring the timing residuals of millisecond pulsars. In this paper, we investigate the constraints on the RGWs and on the inflationary parameters by the observations of current and potential future pulsar timing arrays. In particular, we focus on effects of various cosmic phase transitions (e.g. $e^{+}e^{-}$ annihilation, QCD transition and SUSY breaking) and relativistic free-streaming gases (neutrinos and dark fluids) in the general scenario of the early Universe, which have been neglected in the previous works. We find that the phase transitions can significantly damp the RGWs in the sensitive frequency range of pulsar timing arrays, and the upper limits of tensor-to-scalar ratio $r$ increase by a factor $\\sim 2$ for both current and future observations. However, the effects of free-steaming neutrinos and dark fluids are all too small to be detected. Meanwhile, we find that, i...

  1. Comparison of mean cerebral transit time and single-photon emission tomography for estimation of stroke outcome

    Energy Technology Data Exchange (ETDEWEB)

    Lees, K.R. [Acute Stroke Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow (United Kingdom); Weir, C.J. [Acute Stroke Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow (United Kingdom)]|[Robertson Centre for Biostatistics, University of Glasgow (United Kingdom); Gillen, G.J. [Department of Nuclear Medicine, Western Infirmary, Glasgow (United Kingdom); Taylor, A.K. [Department of Radiology, Western Infirmary, Glasgow (United Kingdom); Ritchie, C. [Acute Stroke Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow (United Kingdom)]|[Department of Occupational Therapy, West Glasgow Hospitals University NHS Trust, Glasgow (United Kingdom)

    1995-11-01

    This study aimed to compare the effectiveness of SPET and mean cerebral transit time (MCTT) in the prediction of functional outcome. Sixty-three patients undergoing cerebral computed tomography (CT), technetium-99m MCTT, and technetium-99m-labelled hexamethylpropylene amine oxime SPET soon after acute ischaemic stroke had outcome assessed after 3 months. Cerebral CT, SPET and MCTT scans were interpreted without reference to the clinical data; a single independent observer assessed outcome using the Barthel Index. The 3-month Barthel score in survivors was significantly correlated with volume of lesion on SPET and with the ratio of mean affected hemisphere transit times to mean unaffected hemisphere transit times, but not with CT lesion volume. Stepwise logistic regression identified volume of lesion on SPET as the only significant predictor of good functional outcome. The overall predictive accuracy was 73%. It is concluded that MCTT, although significantly correlated with functional outcome, failed to predict good functional recovery in individual stroke survivors. Since SPET provides more detailed localisation of perfusion deficits, and since SPET lesion volume can be used to predict functional outcome, SPET remains preferable to MCTT when perfusion imaging is required. (orig./MG)

  2. An investigation of natural and forced transition in a laminar separation bubble via time-resolved Particle Image Velocimetry

    Science.gov (United States)

    Kurelek, John; Yarusevych, Serhiy

    2015-11-01

    The transition process in a laminar separation bubble (LSB) formed on the suction surface of a NACA 0018 airfoil at a chord Reynolds number of 100,000 and an angle of attack of 5° is studied experimentally. Both natural and forced transition are evaluated using controlled acoustic disturbances. Time-resolved Particle Image Velocimetry and surface pressure measurements are used to investigate the streamwise and spanwise flow development in the bubble. For all the cases examined, the transition process is characterized by the formation of strongly periodic shear layer vortices in the LSB due to the amplification of disturbances in the bubble's fore portion. These structures feature strong spanwise coherence at roll-up; however, they deform rapidly and begin to break down upstream of the mean reattachment point. The vortex breakup is shown to be initiated by spanwise deformation of the vortex filaments, linked to the formation of streamwise structures. This is followed by the formation of turbulent spots, which expand rapidly near mean reattachment. The results demonstrate that the acoustic disturbance environment can have a strong influence on the characteristics of the vortices and their breakup, thereby affecting flow transition and the overall dynamics of the LSB.

  3. Abnormal shortened diastolic time length at increasing heart rates in patients with abnormal exercise-induced increase in pulmonary artery pressure

    Directory of Open Access Journals (Sweden)

    Bombardini Tonino

    2011-11-01

    Full Text Available Abstract Background The degree of pulmonary hypertension is not independently related to the severity of left ventricular systolic dysfunction but is frequently associated with diastolic filling abnormalities. The aim of this study was to assess diastolic times at increasing heart rates in normal and in patients with and without abnormal exercise-induced increase in pulmonary artery pressure (PASP. Methods. We enrolled 109 patients (78 males, age 62 ± 13 years referred for exercise stress echocardiography and 16 controls. The PASP was derived from the tricuspid Doppler tracing. A cut-off value of PASP ≥ 50 mmHg at peak stress was considered as indicative of abnormal increase in PASP. Diastolic times and the diastolic/systolic time ratio were recorded by a precordial cutaneous force sensor based on a linear accelerometer. Results At baseline, PASP was 30 ± 5 mmHg in patients and 25 ± 4 in controls. At peak stress the PASP was normal in 95 patients (Group 1; 14 patients (Group 2 showed an abnormal increase in PASP (from 35 ± 4 to 62 ± 12 mmHg; P Conclusion The first and second heart sound vibrations non-invasively monitored by a force sensor are useful for continuously assessing diastolic time during exercise. Exercise-induced abnormal PASP was associated with reduced diastolic time at heart rates beyond 100 beats per minute.

  4. Livergraftvascularvariantwith 3 extra-hepatic arteries

    Institute of Scientific and Technical Information of China (English)

    Paulo N Martins

    2010-01-01

     Vascular anatomy of the liver is varied, and the"standard"anatomy is seen in 55%-80%of cases. It is very important that extrahepatic arteries are identiifed precisely at the time of graft procurement to avoid injuries that might compromise the liver function. In the present case the liver donor had the vascular anatomy of Michels type Ⅶ, e.g. a hepatic artery originating from the celiac trunk and going to the left lobe, an accessory left hepatic artery coming from the left gastric artery, and a replaced right hepatic artery coming from the superior mesenteric artery. This pattern of vascular supply is uncommon, representing less than 5%of cases. The replaced hepatic artery was reconstructed in the back-table with polypropylene suture 7.0 by connecting it to the stump of the splenic artery, and the celiac trunk of the graft was anastomosed to the recipient common hepatic artery.

  5. Carotid artery surgery

    Science.gov (United States)

    Carotid endarterectomy; CAS surgery; Carotid artery stenosis - surgery; Endarterectomy - carotid artery ... through the catheter around the blocked area during surgery. Your carotid artery is opened. The surgeon removes ...

  6. Synchronization-desynchronization transitions in complex networks: an interplay of distributed time delay and inhibitory nodes.

    Science.gov (United States)

    Wille, Carolin; Lehnert, Judith; Schöll, Eckehard

    2014-09-01

    We investigate the combined effects of distributed delay and the balance between excitatory and inhibitory nodes on the stability of synchronous oscillations in a network of coupled Stuart-Landau oscillators. To this end a symmetric network model is proposed for which the stability can be investigated analytically. It is found that beyond a critical inhibition ratio, synchronization tends to be unstable. However, increasing distributional widths can counteract this trend, leading to multiple resynchronization transitions at relatively high inhibition ratios. The extended applicability of the results is confirmed by numerical studies on asymmetrically perturbed network topologies. All investigations are performed on two distribution types, a uniform distribution and a Γ distribution.

  7. Measuring transit time of photomultiplier%光电倍增管渡越时间的测量

    Institute of Scientific and Technical Information of China (English)

    陈钰钰; 唐登攀; 甫跃成

    2013-01-01

      响应时间为10-9 s的LED灯作为光源,使用MCP-PM T测量系统的固有时间特性,用示波器记录波形并获取时间差,实验测量了俄罗斯CHФ型光电倍增管的渡越时间。%In view of the intrinsic time response of MCP-PM T measurement system ,the transit time of a Russia-made CHФ photomultiplier was measured using a fast response (10-9 s) LED light source and an oscillograph .

  8. Performance Analysis of Stop-Skipping Scheduling Plans in Rail Transit under Time-Dependent Demand

    Science.gov (United States)

    Cao, Zhichao; Yuan, Zhenzhou; Zhang, Silin

    2016-01-01

    Stop-skipping is a key method for alleviating congestion in rail transit, where schedules are sometimes difficult to implement. Several mechanisms have been proposed and analyzed in the literature, but very few performance comparisons are available. This study formulated train choice behavior estimation into the model considering passengers’ perception. If a passenger’s train path can be identified, this information would be useful for improving the stop-skipping schedule service. Multi-performance is a key characteristic of our proposed five stop-skipping schedules, but quantified analysis can be used to illustrate the different effects of well-known deterministic and stochastic forms. Problems in the novel category of forms were justified in the context of a single line rather than transit network. We analyzed four deterministic forms based on the well-known A/B stop-skipping operating strategy. A stochastic form was innovatively modeled as a binary integer programming problem. We present a performance analysis of our proposed model to demonstrate that stop-skipping can feasibly be used to improve the service of passengers and enhance the elasticity of train operations under demand variations along with an explicit parametric discussion. PMID:27420087

  9. Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca.

    Science.gov (United States)

    Griffiths, Kate; Hou, Rong; Wang, Hairui; Zhang, Zhihe; Zhang, Liang; Zhang, Tong; Watson, David G; Burchmore, Richard J S; Loeffler, I Kati; Kennedy, Malcolm W

    2015-10-01

    Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection. Comparison of bear milks with milks of other eutherians yielded distinctive protein profiles. Proteomic and metabolomic analysis of serial milk samples collected from six giant pandas showed a prolonged transition from colostrum to main-phase lactation over approximately 30 days. Particularly striking are the persistence or sequential appearance of adaptive and innate immune factors. The endurance of immunoglobulin G suggests an unusual duration of trans-intestinal absorption of maternal antibodies, and is potentially relevant to the underdeveloped lymphoid system of giant panda neonates. Levels of certain milk oligosaccharides known to exert anti-microbial activities and/or that are conducive to the development of neonatal gut microbiomes underwent an almost complete changeover around days 20-30 postpartum, coincident with the maturation of the protein profile. A potential metabolic marker of starvation was detected, the prominence of which may reflect the natural postpartum period of anorexia in giant panda mothers. Early lactation in giant pandas, and possibly in other ursids, appears to be adapted for the unique requirements of unusually altricial eutherian neonates. PMID:26587250

  10. A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

    Science.gov (United States)

    Abuhelwa, Ahmad Y; Foster, David J R; Upton, Richard N

    2016-09-01

    This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) transit times of non-disintegrating single-unit ("tablet") and multiple-unit ("pellets/multi-unit tablet") solid dosage forms, characterize the effect of food on the values and variability in these parameters and present quantitative meta-models of the distributions of GI transit times in the respective GI regions to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, gastric, small intestinal and colonic transit times under fed and fasted conditions. Meta-analysis used the "metafor" package of the R language. Meta-models of GI transit were assumed to be log-normally distributed between the studied populations. Twenty-nine studies including 125 reported means and standard deviations were used in the meta-analysis. Caloric content of administered food increased variability and delayed the gastric transit of both pellets and tablets. Conversely, food caloric content reduced the variability but had no significant influence on the mean small intestinal transit time (SITT). Food had no significant effect on the transit time through the colon. The transit of pellets through the colon was significantly slower than that of single-unit tablets which is most likely related to their smaller size. GI transit times may influence the dissolution and absorption of oral drugs. The meta-models of GI transit times may be used as part of semi-physiological absorption models to characterize the influence of transit time on the dissolution, absorption and in vivo pharmacokinetic profiles of oral drugs. PMID:27439620

  11. A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

    Science.gov (United States)

    Abuhelwa, Ahmad Y; Foster, David J R; Upton, Richard N

    2016-09-01

    This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) transit times of non-disintegrating single-unit ("tablet") and multiple-unit ("pellets/multi-unit tablet") solid dosage forms, characterize the effect of food on the values and variability in these parameters and present quantitative meta-models of the distributions of GI transit times in the respective GI regions to help inform models of oral drug absorption. The literature was systemically reviewed for the values of, and the variability in, gastric, small intestinal and colonic transit times under fed and fasted conditions. Meta-analysis used the "metafor" package of the R language. Meta-models of GI transit were assumed to be log-normally distributed between the studied populations. Twenty-nine studies including 125 reported means and standard deviations were used in the meta-analysis. Caloric content of administered food increased variability and delayed the gastric transit of both pellets and tablets. Conversely, food caloric content reduced the variability but had no significant influence on the mean small intestinal transit time (SITT). Food had no significant effect on the transit time through the colon. The transit of pellets through the colon was significantly slower than that of single-unit tablets which is most likely related to their smaller size. GI transit times may influence the dissolution and absorption of oral drugs. The meta-models of GI transit times may be used as part of semi-physiological absorption models to characterize the influence of transit time on the dissolution, absorption and in vivo pharmacokinetic profiles of oral drugs.

  12. Time delay and long-range connection induced synchronization transitions in Newman-Watts small-world neuronal networks.

    Science.gov (United States)

    Qian, Yu

    2014-01-01

    The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay τ and long-range connection (LRC) probability P have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability P = 1.0 as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability P is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs.

  13. A tentative study for the prediction of the CME related geomagnetic storm intensity and its transit time

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Xinhua; FENG; Xueshang

    2005-01-01

    Using 80 CME-ICME events during 1997.1―2002.9, based on the eruptive source locations of CMEs and solar magnetic field observation at the photosphere, a current sheet magnetic coordinate (CMC) system is established in order to study the propagation of CME and its geoeffectiveness. In context of this coordinate system, the effect of the eruptive source location and the form of heliospheric current sheet (HCS) at the eruptive time of CME on the geomagnetic storm intensity caused by CME and the CME's transit time at the Earth is investigated in detail. Our preliminary conclusions are: 1) The geomagnetic disturbances caused by CMEs tend to have the so-called "same side-opposite side effect", I.e. CMEs erupt from the same side of the HCS as the earth would be more likely to arrive at the earth and the geomagnetic disturbances associated with them tend to be of larger magnitude, while CMEs erupting from the opposite side would arrive at the earth with less probability and the corresponding geomagnetic disturbance magnitudes would be relatively weaker. 2) The angular separation between the earth and the HCS affect the corresponding disturbance intensity. That is, when our earth is located near the HCS, adverse space weather events occur most probably. 3) The erupting location of the CME and its nearby form of HCS will also affect its arrival time at the earth. According to these conclusions, in this context of CMC coordinate we arrive at new prediction method for estimating the geomagnetic storm intensity (Dstmin) caused by CMEs and their transit times. The application of the empirical model for 80 CME-ICME events shows that the relative error of Dst is within 30% for 59% events with Dstmin≤-50 nT, while the averaged absolute error of transit time is lower than 10 h for all events.

  14. Laparoscopic gastric bypass to robotic gastric bypass: time and cost commitment involved in training and transitioning an academic surgical practice.

    Science.gov (United States)

    Lyn-Sue, Jerome R; Winder, Josh S; Kotch, Shannon; Colello, Jacob; Docimo, Salvatore

    2016-06-01

    The Roux-en-Y gastric bypass is the gold standard procedure for weight loss. This relatively complex procedure has excellent outcomes when performed via laparoscopy. The advent of the DaVinci robotic platform has been a technological advancement. Our goal is to provide information regarding the cost, time commitment, and advantages of transitioning an LRYGB program to an RRYGB program in an academic setting. We retrospectively reviewed the last 25 laparoscopic gastric bypass procedures and the first 25 robotic gastric bypass procedures performed by a single surgeon. We compared clinical outcomes and focused on time and hospital cost during this transition phase. There was no significant demographic difference between the groups. The mean age was 41.7 (RRYGB) years vs 43.4 (LRYGM) years. The mean BMI were similar between groups, 45.3 vs 46.5 kg/m(2) for RRYGB and LRYGB. No anastomotic leaks or mortalities were noted. There was one anastomotic stricture in both groups. Excess weight loss was similar in both groups at 1 year. There was a significant increase in operative time with RRYGB, mean 241 min vs mean 174 min (p = 0.0005). Operative time fell by 25 min after the first 10 cases. The hospital cost was also increased with RRYGB mean $5922 vs $4395 (p = 0.03). Transitioning from a laparoscopic to a robotic practice can be done safely, however, the initial operative times were longer and the hospital cost was higher for robotic gastric bypass. We hope in the future that these will decrease after overcoming the learning and as the technology becomes widespread.

  15. Determination of Scheduled Travel Time for a Fixed Transit Route Based on Multistate Model

    Institute of Scientific and Technical Information of China (English)

    Shukai Chen; Daniel Jian Sun; and Rui Xue

    2016-01-01

    In order to provide the guideline for bus drivers to adjust speed to minimize scheduled deviation, the method for setting bus scheduled travel time is proposed. Firstly, multistate model is introduced to fit historical travel time data and identify different service states. Based on the calibrated travel time distribution parameters, an optimization model is proposed, followed by a Monte Carlo ( MC) simulation based genetic algorithm ( GA) procedure to obtain the optimal scheduled time. A case study from a fixed bus route from Shenzhen is used to demonstrate the model applicability. The sensitivity analysis is conducted to study the effects of parameters setting on optimal slack time for each segment. The results show that multistate model fits travel time under peak hours better than Lognormal distribution, and the length of scheduled travel time basically reflects travel time reliability.

  16. Sol-to-Gel Transition in Fast Evaporating Systems Observed by in Situ Time-Resolved Infrared Spectroscopy.

    Science.gov (United States)

    Innocenzi, Plinio; Malfatti, Luca; Carboni, Davide; Takahashi, Masahide

    2015-06-22

    The in situ observation of a sol-to-gel transition in fast evaporating systems is a challenging task and the lack of a suitable experimental design, which includes the chemistry and the analytical method, has limited the observations. We synthesise an acidic sol, employing only tetraethylorthosilicate, SiCl4 as catalyst and deuterated water; the absence of water added to the sol allows us to follow the absorption from the external environment and the evaporation of deuterated water. The time-resolved data, obtained by attenuated total reflection infrared spectroscopy on an evaporating droplet, enables us to identify four different stages during evaporation. They are linked to specific hydrolysis and condensation rates that affect the uptake of water from external environment. The second stage is characterized by a decrease in hydroxyl content, a fast rise of condensation rate and an almost stationary absorption of water. This stage has been associated with the sol-to-gel transition.

  17. Theory for transitions between log and stationary phases: universal laws for lag time

    CERN Document Server

    Himeoka, Yusuke

    2016-01-01

    Quantitative characterization of bacterial growth has gathered substantial attention since Monod's pioneering study. Theoretical and experimental work has uncovered several laws for describing the log growth phase, in which the number of cells grows exponentially. However, microorganism growth also exhibits lag, stationary, and death phases under starvation conditions, in which cell growth is highly suppressed, while quantitative laws or theories for such phases are underdeveloped. In fact, models commonly adopted for the log phase that consist of autocatalytic chemical components, including ribosomes, can only show exponential growth or decay in a population, and phases that halt growth are not realized. Here, we propose a simple, coarse-grained cell model that includes inhibitor molecule species in addition to the autocatalytic active protein. The inhibitor forms a complex with active proteins to suppress the catalytic process. Depending on the nutrient condition, the model exhibits the typical transition a...

  18. Zodiacal Exoplanets in Time (ZEIT) IV: seven transiting planets in the Praesepe cluster

    CERN Document Server

    Mann, Andrew W; Vanderburg, Andrew; Rizzuto, Aaron C; Ansdell, Megan; Medina, Jennifer Vanessa; Mace, Gregory N; Kraus, Adam L

    2016-01-01

    Open clusters and young stellar associations are attractive sites to search for planets and to test theories of planet formation, migration, and evolution. We present our search for, and characterization of, transiting planets in the $\\simeq$800 Myr old Praesepe (Beehive, M44) Cluster from K2 light curves. We identify seven planet candidates, six of which we statistically validate to be real planets. For each host star we obtain high-resolution NIR spectra to measure its projected rotational broadening and radial velocity, the latter of which we use to confirm cluster membership. We obtain low-resolution optical and NIR spectroscopy for each system, which we use in conjunction with the cluster distance and metallicity to provide precise temperatures, masses, radii, and luminosities for the host stars. Combining our measurements of rotational broadening, rotation periods from the K2 light curves, and our derived stellar radii, we show that all planetary orbits are, within errors, aligned with their host star's...

  19. Neanderthal genomics suggests a pleistocene time frame for the first epidemiologic transition.

    Science.gov (United States)

    Houldcroft, Charlotte J; Underdown, Simon J

    2016-07-01

    High quality Altai Neanderthal and Denisovan genomes are revealing which regions of archaic hominin DNA have persisted in the modern human genome. A number of these regions are associated with response to infection and immunity, with a suggestion that derived Neanderthal alleles found in modern Europeans and East Asians may be associated with autoimmunity. As such Neanderthal genomes are an independent line of evidence of which infectious diseases Neanderthals were genetically adapted to. Sympathetically, human genome adaptive introgression is an independent line of evidence of which infectious diseases were important for AMH coming in to Eurasia and interacting with Neanderthals. The Neanderthals and Denisovans present interesting cases of hominin hunter-gatherers adapted to a Eurasian rather than African infectious disease package. Independent sources of DNA-based evidence allow a re-evaluation of the first epidemiologic transition and how infectious disease affected Pleistocene hominins. By combining skeletal, archaeological and genetic evidence from modern humans and extinct Eurasian hominins, we question whether the first epidemiologic transition in Eurasia featured a new package of infectious diseases or a change in the impact of existing pathogens. Coupled with pathogen genomics, this approach supports the view that many infectious diseases are pre-Neolithic, and the list continues to expand. The transfer of pathogens between hominin populations, including the expansion of pathogens from Africa, may also have played a role in the extinction of the Neanderthals and offers an important mechanism to understand hominin-hominin interactions well back beyond the current limits for aDNA extraction from fossils alone. Am J Phys Anthropol 160:379-388, 2016. © 2016 Wiley Periodicals, Inc. PMID:27063929

  20. Spatiotemporal interference of photoelectron wave packets and the time scale of nonadiabatic transitions in the high-frequency regime

    Science.gov (United States)

    Toyota, Koudai

    2016-10-01

    The method of the envelope Hamiltonian [K. Toyota, U. Saalmann, and J. M. Rost, New J. Phys. 17, 073005 (2015), 10.1088/1367-2630/17/7/073005] is applied to further study a detachment dynamics of a model negative ion in one dimension in the high-frequency regime. This method is based on the Floquet approach, but the time dependency of an envelope function is explicitly kept for arbitrary pulse durations. Therefore, it is capable of describing not only a photon absorption or emission, but also a nonadiabatic transition which is induced by the time-varying envelope of the pulse. It was shown that the envelope Hamiltonian accurately retrieves the results obtained by the time-dependent Schrödinger equation, and the underlying physics were well understood by the adiabatic approximation based on the envelope Hamiltonian. In this paper, we explore two more aspects of the detachment dynamics, which were not considered in our previous work. First, we determine the features of both a spatial and temporal interference of photoelectron wave packets in a photon-absorption process. We conclude that both of the interference mechanisms are universal in ionization dynamics in the high-frequency regime. Second, we extract a pulse duration which maximizes a yield of the nonadiabatic transition as a function of a pulse duration. It is shown that it becomes maximum when the pulse duration is comparable to a time scale of an electron.

  1. Carotid Artery Screening

    Science.gov (United States)

    ... Resources Professions Site Index A-Z Carotid Artery Screening What is carotid artery screening? Who should consider ... about carotid artery screening? What is carotid artery screening? Screening examinations are tests performed to find disease ...

  2. Lower order moments of inter-transition times in the stationary QBD process

    DEFF Research Database (Denmark)

    Andersen, Allan T.; Neuts, Marcel; Nielsen, Bo Friis

    2000-01-01

    The epochs in which successive increases-or decreases-in the levels of a quasi birth-and-death process QBD process occur are of special interest. In queueing models they usually correspond to the times of successive increments or decrements. We derive general formulas for the variances of the times...

  3. Characterization of the KOI-94 System with Transit Timing Variation Analysis: Implication for the Planet-Planet Eclipse

    CERN Document Server

    Masuda, Kento; Taruya, Atsushi; Nagasawa, Makiko; Suto, Yasushi

    2013-01-01

    The KOI-94 system is a closely-packed, multi-transiting planetary system discovered by the Kepler space telescope. It is known as the first system that exhibited a rare event called a "planet-planet eclipse (PPE)," in which two planets partially overlap with each other in their double-transit phase. In this paper, we constrain the parameters of the KOI-94 system with an analysis of the transit timing variations (TTVs). Such constraints are independent of the radial velocity (RV) analysis recently performed by Weiss and coworkers, and valuable in examining the reliability of the parameter estimate using TTVs. We numerically fit the observed TTVs of KOI-94c, KOI-94d, and KOI-94e for their masses, eccentricities, and longitudes of periastrons, and obtain the best-fit parameters including $m_{\\rm c} = 9.4_{-2.1}^{+2.4} M_{\\oplus}$, $m_{\\rm d} = 52.1_{-7.1}^{+6.9} M_{\\oplus}$, $m_{\\rm e} = 13.0_{-2.1}^{+2.5} M_{\\oplus}$, and $e \\lesssim 0.1$ for all the three planets. While these values are mostly in agreement wit...

  4. Radiographic-anatomical aspects and gastrointestinal transit time in the spectacled caiman Caiman crocodilus crocodilus (Linnaeus, 1758 (Crocodylia, Alligatoridae

    Directory of Open Access Journals (Sweden)

    Heloisa Castro Pereira

    2014-09-01

    Full Text Available In Brazil, there is increasing interest in the establishment of captive breeding programs for caiman. However, there is a paucity of in-depth studies on the proper care of these reptiles in captivity, particularly regarding optimal food type and frequency of feeding. The purpose of this study was to determine radiographic-anatomical aspects of, and gastrointestinal transit time of Caiman crocodilus crocodilus using contrast radiography. Ten caiman were used in the study, five males and five females, the animals were physically restrained for administration of a radiographic contrast medium, consisting of 10 ml/kg barium sulfate and mineral oil suspension (70%: 30% respectively, via the orogastric tube. Following contrast medium administration, radiographs were taken via dorsoventral projection first at five minutes, then at 6, 24, 30, 48, 54, 72, 80, 96, 104, 120, 130, 144 and 150 hours. This technique allows visualization of contrast medium passage through the GI tract, which enabled determination of gastrointestinal transit time in the spectacled caiman. The average time for contrast medium passage through the digestive tract of this species was 117 ± 29.6 h for females and 86.4 ± 21.5 h for males.

  5. Use of seismocardiogram for the beat-to-beat assessment of the Pulse Transit Time: A pilot study.

    Science.gov (United States)

    Di Rienzo, Marco; Vaini, Emanuele; Lombardi, Prospero

    2015-08-01

    We propose a new methodology for the estimation of Pulse Transit Time, PTT, based on the use of the seismocardiogram for the identification of the aortic valve opening, AO. This method has been implemented to obtain a first description of the AO-derived PTT beat-to-beat variability at rest and during the recovery after a cycloergometer exercise at 25W and 100W, its relation with systolic blood pressure, S(BP), and its difference with respect to variability of the Pulse Arrival Time, PAT (i.e. the BP transit time estimated by considering the ECG R peak instead of AO as proximal site). Our preliminary data indicate that 1) the fast components of the PTT variability are only marginally influenced by respiration; 2) only the slower components of the PTT variability are correlated with systolic BP; 3) major differences exist in the dynamics of PTT and PAT, being PAT variability significantly larger and importantly influenced by the beat-to-beat changes occurring in the Pre Ejection Period. PMID:26737949

  6. Transit time distributions to assess present and future contamination risk of karst aquifers over Europe and the Mediterranean

    Science.gov (United States)

    Hartmann, Andreas; Gleeson, Tom; Wada, Yoshihide; Wagener, Thorsten

    2016-04-01

    Karst develops through the dissolution of carbonate rock. Karst groundwater in Europe is a major source of fresh water contributing up to half of the total drinking water supply in some countries. Climate model projections suggest that in the next 100 years, karst regions will experience a strong increase in temperature and a serious decrease of precipitation - especially in the Mediterranean region. Previous work showed that the karstic preferential recharge processes result in enhanced recharge rates and future climate sensitivity. But as there is fast water flow form the surface to the aquifer, there is also an enhanced risk of groundwater contamination. In this study we will assess the contamination risk of karst aquifers over Europe and the Mediterranean using simulated transit time distributions. Using a new type of semi-distributed model that considers the spatial heterogeneity of the karst system by distribution functions we simulated a range of spatially variable pathways of karstic groundwater recharge. The model is driven by the bias-corrected 5 GCMs of the ISI-MIP project (RCP8.5). Transit time distributions are calculated by virtual tracer experiments. These are repeated several times in the present (1991-2010) and the future (2080-2099). We can show that regions with larger fractions of preferential recharge show higher risks of contamination and that spatial patterns of contamination risk change towards the future.

  7. A Comparative Analysis of the Price Index in Transition Countries in the Time of Globalisation

    Directory of Open Access Journals (Sweden)

    Pejović Igor

    2014-01-01

    Full Text Available Globalisation with all its features can be divided in two segments - good and bad. When we look at the good side of globalisation, it is obvious that it has erased boundaries between countries in terms of trade, education, knowledge sharing, and other new technologies, while on the other hand, the bad side is that it has created a considerable gap between developed and developing countries, then different types of commercial, political and other conditioning, and dependence on strong, developed states. A great contribution to the negative part of globalisation was of economic instability that occurred at the beginning of this century and which consequences are still present in the world. In this article, we presented the impact of economic instability on the price index trough a comparative analysis of transition countries such as Montenegro, Serbia and Croatia over a period of five years (Croatia has just recently become a member of the European Union and due to that fact it was included in this study. The survey covered price indices relating to the prices of industrial products for the domestic markets, consumer price indices, indices of the hospitality services and the prices of the agricultural products.

  8. Time-resolved fluorescence spectroscopy of matrix-isolated silver atoms after pulsed excitation of inner-shell transitions

    Science.gov (United States)

    Hebert, T.; Wiggenhauser, H.; Schriever, U.; Kolb, D. M.

    1990-02-01

    The energy dissipation in matrix-isolated silver atoms after pulsed vacuum ultraviolet (VUV) excitation of 4d-5p transitions has been studied by time-resolved fluorescence spectroscopy. The decay behavior of the various fluorescence bands has been analyzed and a model for the relaxation process proposed within the framework of a two-dimensional configuration-coordinate diagram. If minute quantities of Ag2 are present in the matrix, the analysis requires consideration of energy transfer between silver atoms and dimers.

  9. Probing Reaction Dynamics of Transition-Metal Complexes in Solution via Time-Resolved X-ray Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Huse, Nils; Khalil, Munira; Kim, Tae Kyu; Smeigh, Amanda L.; Jamula, Lindsey; McCusker, James K.; Schoenlein, Robert W.

    2009-05-24

    We report measurements of the photo-induced Fe(II) spin crossover reaction dynamics in solution via time-resolved x-ray absorption spectroscopy. EXAFS measurements reveal that the iron?nitrogen bond lengthens by 0.21+-0.03 Angstrom in the high-spin transient excited state relative to the ground state. XANES measurements at the Fe L-edge show directly the influence of the structural change on the ligand-field splitting of the Fe(II) 3d orbitals associated with the spin transition.

  10. Probing reaction dynamics of transition-metal complexes in solution via time-resolved X-ray spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Huse, Nils [Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1Cyclotron Road, Berkeley, CA 94720 (United States); Khalil, Munira [Department of Chemistry, University of Washington, Seattle, WA 98195 (United States); Kim, Tae Kyu [Department of Chemistry, Pusan National University, Busan 609-735 (Korea, Republic of); Smeigh, Amanda L; Jamula, Lindsey; McCusker, James K [Department of Chemistry, Michigan State University, East Lansing, MI 48824 (United States); Schoenlein, Robert W, E-mail: nhuse@lbl.go, E-mail: rwschoenlein@lbl.go [Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA (United States)

    2009-02-01

    We report measurements of the photoinduced Fe{sup II} spin crossover reaction dynamics in solution via time-resolved x-ray absorption spectroscopy. EXAFS measurements reveal that the iron-nitrogen bond lengthens by 0.21+-0.03 A in the high-spin transient excited state relative to the ground state. XANES measurements at the Fe L-edge show directly the influence of the structural change on the ligand-field splitting of the Fe{sup II} 3d orbitals associated with the spin transition.

  11. Heparin Therapy during Extracorporeal Circulation: Deriving an Optimal Activated Clotting Time during Cardiopulmonary Bypass for Isolated Coronary Artery Bypass Grafting

    OpenAIRE

    Palmer, Kenneth; Ridgway, Tim; Al-Rawi, Omar; Poullis, Michael

    2012-01-01

    Bull’s seminal work on heparin therapy during cardiopulmonary bypass (CPB) was carried out over 30 years ago and has not been updated in the modern era. No correlation with postoperative blood loss was performed. The optimal activated clotting time (ACT) with regard to blood loss has not been established for patients undergoing CPB. A minimum ACT of 400 is based on the lack of visible formation of clots in the CPB circuit. The effect of heparin dose, sensitivity, metabolism, patient size, ele...

  12. Positron life time and annihilation Doppler broadening measurements on transition metal complexes

    Energy Technology Data Exchange (ETDEWEB)

    Levay, B. (Eoetvoes Lorand Tudomanyegyetem, Budapest (Hungary). Fizikai Kemiai es Radiologiai Tanszek); Varhelyi, Cs. (Babes-Bolyai Univ., Cluj (Romania)); Burger, K. (Eoetvoes Lorand Tudomanyegyetem, Budapest (Hungary). Szervetlen es Analitikai Kemiai Intezet)

    1982-01-01

    Positron life time and annihilation Doppler broadening measurements have been carried out on 44 solid coordination compounds. Several correlations have been found between the annihilation life time (tau/sub 1/) and line shape parameters (L) and the chemical structure of the compounds. Halide ligands were the most active towards positrons. This fact supports the assumption on the possible formation of (e/sup +/X/sup -/) positron-halide bound state. The life time was decreasing and the annihilation energy spectra were broadening with the increasing negative character of the halides. The aromatic base ligands affected the positron-halide interaction according to their basicity and space requirement and thus they indirectly affected the annihilation parameters, too. In the planar and tetrahedral complexes the electron density on the central met--al ion affected directly the annihilation parameters, while in the octahedral mixed complexes it had only an ind--irect effect through the polarization of the halide ligands.

  13. Signal transceiver transit times and propagation delay corrections for ranging and geo-referencing applications

    CERN Document Server

    Kaufmann, P; Pamboukian, S V D; de Morais, R Vilhena

    2012-01-01

    The changes in phase, time and frequency suffered by signals when retransmitted by a remote and inaccessible transponder and the propagation delays are major constraints to obtain accurate ranging measurements in various related applications. We present a new method and system to determine these delays for every single pulsed signal transmission. The process utilizes four ground-based reference stations, synchronized in time and installed at well known geodesic coordinates. The repeater station is located within the fields of view common to the four reference bases, such as in a platform transported by a satellite, balloon, aircraft, etc. Signal transmitted by one of the reference bases is retransmitted by the transponder, received back by the four bases, producing four ranging measurements which are processed to determine uniquely the time delays undergone in every retransmission process. The repeater's positions with respect to each group of three out of four reference bases are given by a system of equatio...

  14. Investigating transition state resonances in the time domain by means of Bohmian mechanics: The F + HD reaction

    International Nuclear Information System (INIS)

    Graphical abstract: It is shown how Bohmian trajectories can provide alternative, insightful information about the formation and development of transition state resonances in chemical reactions, thus constituting an interesting tool to explore and analyze these phenomena. Highlights: ► The product channel of the F + HD exhibits resonance-mediated dynamics. ► The role of quantum trajectories as a tool to explore and to investigate transition state resonances is analyzed. ► A reduced two-dimensional model is proposed. ► Additional information to former wave packets calculations can be then obtained. ► Reduced quantum trajectories show how and where probability gets trapped, giving rise to the resonance. - Abstract: In this work, we investigate the existence of transition state resonances on atom–diatom reactive collisions from a time-dependent perspective, stressing the role of quantum trajectories as a tool to analyze this phenomenon. As it is shown, when one focusses on the quantum probability current density, new dynamical information about the reactive process can be extracted. In order to detect the effects of the different rotational populations and their dynamics/coherences, we have considered a reduced two-dimensional dynamics obtained from the evolution of a full three-dimensional quantum time-dependent wave packet associated with a particular angle. This reduction procedure provides us with information about the entanglement between the radial degrees of freedom (r, R) and the angular one (γ), which can be considered as describing an environment. The combined approach here proposed has been applied to study the F + HD reaction, for which the FH + D product channel exhibits a resonance-mediated dynamics.

  15. Estimation of transit times in a Karst Aquifer system using environmental tracers: Application on the Jeita Aquifer system-Lebanon.

    Science.gov (United States)

    Doummar, Joanna; Hamdan, Ahmad

    2016-04-01

    Estimating transit times is essential for the assessment of aquifer vulnerability to contaminants. Groundwater in karst aquifer is assumed to be relatively young due to fast preferential pathways; slow flow components are present in water stored in the fissured matrix. Furthermore, transit times are site specific as they depend on recharge rates, temperatures, elevation, and flow media; saturated and unsaturated zones. These differences create significant variation in the groundwater age in karst systems as the water sampled will be a mix of different water that has been transported through different flow pathways (fissured matrix and conduits). Several methods can be applied to estimate water transit time of an aquifer such as artificial tracers, which provide an estimate for fast flow velocities. In this study, groundwater residence times in the Jeita spring aquifer (Lebanon) were estimated using several environmental tracers such as Chlorofluorocarbons (CFCs), Sulfur Hexafluoride (SF6), Helium-Tritium (3H, 3H- 3He). Additional stable isotope and major ion analysis was performed to characterize water types. Groundwater samples were collected from six different wells in the Jeita catchment area (Jurassic Kesrouane aquifer) as well as from the spring and cave itself. The results are reproducible for the Tritium-Helium method, unlike for the CFC/SF6 methods that yielded poor results due to sampling problems. Tritium concentrations in all groundwater samples show nearly the same concentration (~2.73 TU) except for one sample with relatively lower tritium concentration (~2.26 TU). Ages ranging from 0.07 ± 0.07 years to 23.59 ± 0.00 years were obtained. The youngest age is attributed to the spring/ cave while the oldest ages were obtained in wells tapping the fissured matrix. Neon in these samples showed considerable variations and high delta Ne in some samples indicating high excess air. Four (4) samples showed extreme excess air (Delta-Ne is greater than 70 %) and

  16. Short-Time Events, Coherence, and Structural Dynamics in Photochemistry of Aqueous Halogenated Transition Metal Dianions

    Directory of Open Access Journals (Sweden)

    Pascher T.

    2013-03-01

    Full Text Available Ultrafast pump-probe spectroscopy, time-resolved x-ray absorption, and computational photochemistry elucidate the photochemical pathway of hexabromoplatinate dianions that propagates through distortions of nascent penta-bromoplatinate anions caused by Jahn-Teller conical intersections and terminates at aquated product complexes.

  17. A phase transition model for the speed-accuracy trade-off in response time experiments

    NARCIS (Netherlands)

    G. Dutilh; E.-J. Wagenmakers; I. Visser; H.L.J. van der Maas

    2011-01-01

    Most models of response time (RT) in elementary cognitive tasks implicitly assume that the speed-accuracy trade-off is continuous: When payoffs or instructions gradually increase the level of speed stress, people are assumed to gradually sacrifice response accuracy in exchange for gradual increases

  18. Extended Coherence Time on the Clock Transition of Optically Trapped Rubidium

    DEFF Research Database (Denmark)

    Kleine Büning, G.; Will, J.; Ertmer, W.;

    2011-01-01

    Optically trapped ensembles are of crucial importance for frequency measurements and quantum memories but generally suffer from strong dephasing due to inhomogeneous density and light shifts. We demonstrate a drastic increase of the coherence time to 21 s on the magnetic field insensitive clock t...

  19. Structural transitions and long-time self-diffusion of interacting colloids confined by a parabolic potential.

    Science.gov (United States)

    Euán-Díaz, Edith C; Herrera-Velarde, Salvador; Misko, Vyacheslav R; Peeters, François M; Castañeda-Priego, Ramón

    2015-01-14

    We report on the ordering and dynamics of interacting colloidal particles confined by a parabolic potential. By means of Brownian dynamics simulations, we find that by varying the magnitude of the trap stiffness, it is possible to control the dimension of the system and, thus, explore both the structural transitions and the long-time self-diffusion coefficient as a function of the degree of confinement. We particularly study the structural ordering in the directions perpendicular and parallel to the confinement. Further analysis of the local distribution of the first-neighbors layer allows us to identify the different structural phases induced by the parabolic potential. These results are summarized in a structural state diagram that describes the way in which the colloidal suspension undergoes a structural re-ordering while increasing the confinement. To fully understand the particle dynamics, we take into account hydrodynamic interactions between colloids; the parabolic potential constricts the available space for the colloids, but it does not act on the solvent. Our findings show a non-linear behavior of the long-time self-diffusion coefficient that is associated to the structural transitions induced by the external field.

  20. Long-term effect of wholemeal bread on stool weight, transit time, fecal bile acids, fats, and neutral sterols.

    Science.gov (United States)

    Eastwood, M A; Elton, R A; Smith, J H

    1986-03-01

    Stool weight, fecal constituents, bile acids, fat, neutral sterols, and intestinal transit time were recorded in 28 subjects over 18 mo. During the first 12 mo the subjects ate white bread. They were studied for an initial period of 7 days, and after 6 mo (study period 1). For the first 6 mo they ate their usual intake of bread, they then increased their white bread intake by 62 g/day for 6 mo (study period 2). The subjects ate a self-selected diet throughout the 18 mo study. During the last 6 mo (study period 3) the subjects replaced white bread by the same amount of wholemeal bread as in study period 2. No increase in stool weight occurred until study period 3 when there was an increase of 20%. There developed a linear relationship between stool weight and intestinal transit time which was not found during the initial first and second study periods. A seasonal influence on serum cholesterol was not observed during the wholemeal bread period. Fecal bile acid excretion was unchanged throughout the experiment.