Sample records for arterial tone effets

  1. Increased arterial vascular tone during the night in patients with essential hypertension

    DEFF Research Database (Denmark)

    Scholze, A; Burkert, A; Mardanzai, K;


    The time-dependent incidence of cardiovascular events points to an important role of chronobiology for arterial properties. To evaluate arterial properties in patients with essential hypertension, we assessed arterial vascular tone during sleep at night in patients with essential hypertension...

  2. Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed. (United States)

    Shatarat, Amjad; Dunn, William R; Ralevic, Vera


    The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries. The aim of the present study was to determine whether tone influences the involvement of ATP as a sympathetic cotransmitter with noradrenaline in another species. We used the porcine perfused mesenteric arterial bed and porcine mesenteric large, medium and small arteries mounted for isometric tension recording, because purinergic cotransmission can vary depending on the size of the blood vessel. In the perfused mesenteric bed at basal tone, sympathetic neurogenic vasocontractile responses were abolished by prazosin, an α1-adrenoceptor antagonist, but there was no significant effect of α,β-methylene ATP, a P2X receptor-desensitizing agent. Submaximal precontraction of the mesenteric arterial bed with U46619, a thromboxane A2 mimetic, augmented the sympathetic neurogenic vasocontractile responses; under these conditions, both α,β-methylene ATP and prazosin attenuated the neurogenic responses. In the mesenteric large, medium and small arteries, prazosin attenuated the sympathetic neurogenic contractile responses under conditions of both basal and U46619-raised tone. α,β-Methylene ATP was effective in all of these arteries only under conditions of U46619-induced tone, causing a similar inhibition in all arteries, but had no significant effect on sympathetic neurogenic contractions at basal tone. These data show that ATP is a cotransmitter with noradrenaline in porcine mesenteric arteries; the purinergic component was revealed under conditions of partial precontraction, which is more relevant to physiological conditions.

  3. Small artery tone under control of the endothelium : on the importance of EDHF and myogenic tone in organ (dys)function

    NARCIS (Netherlands)

    Gschwend, Simone Katharina


    Small artery tone is a major determinant of organ tissue blood flow and of total peripheral resistance. Pathophysiological alterations in small artery function towards a more constrictive state (“small artery dysfunction”) restricts the organ’s blood supply, and increases peripheral vascular resista

  4. Chronic hypoxia during gestation enhances uterine arterial myogenic tone via heightened oxidative stress.

    Directory of Open Access Journals (Sweden)

    Daliao Xiao

    Full Text Available Chronic hypoxia during gestation has profound adverse effects on the adaptation of uteroplacental circulation in pregnancy. Yet, the underlying mechanisms are not fully understood. The present study tested the hypothesis that enhanced production of reactive oxygen species (ROS in uterine arteries plays a critical role in the maladaptation of uterine circulation associated with chronic hypoxia. Uterine arteries were isolated from nonpregnant and near-term pregnant sheep maintained at sea level (~300 m or exposed to high-altitude (3801 m hypoxia for 110 days. Hypoxia significantly increased ROS production in uterine arteries of pregnant, but not nonpregnant, sheep. This was associated with a significant increase in NADPH oxidase (Nox 2, but not Nox1 or Nox4, protein abundance and total Nox activity in uterine arteries of pregnant animals. Chronic hypoxia significantly increased pressure-dependent uterine arterial myogenic tone in pregnant sheep, which was abrogated by a Nox inhibitor apocynin. Additionally, the hypoxia-induced increase in myogenic reactivity of uterine arteries to phorbol 12,13-dibutyrate in pregnant sheep was blocked by apocynin and tempol. In consistence with the myogenic responses, the hypoxia-mediated down-regulation of BKCa channel activity in uterine arteries of pregnant animals was reversed by apocynin. The findings suggest that heightened oxidative stress in uterine arteries plays a key role in suppressing the BKCa channel activity, resulting in increased myogenic reactivity and maladaptation of uteroplacental circulation caused by chronic hypoxia during gestation.

  5. PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries. (United States)

    Mauban, Joseph R H; Zacharia, Joseph; Fairfax, Seth; Wier, Withrow Gil


    Myogenic tone is an intrinsic property of the vasculature that contributes to blood pressure control and tissue perfusion. Earlier investigations assigned a key role in myogenic tone to phospholipase C (PLC) and its products, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). Here, we used the PLC inhibitor, U-73122, and two other, specific inhibitors of PLC subtypes (PI-PLC and PC-PLC) to delineate the role of PLC in myogenic tone of pressurized murine mesenteric arteries. U-73122 inhibited depolarization-induced contractions (high external K(+) concentration), thus confirming reports of nonspecific actions of U-73122 and its limited utility for studies of myogenic tone. Edelfosine, a specific inhibitor of PI-PLC, did not affect depolarization-induced contractions but modulated myogenic tone. Because PI-PLC produces IP3, we investigated the effect of blocking IP3 receptor-mediated Ca(2+) release on myogenic tone. Incubation of arteries with xestospongin C did not affect tone, consistent with the virtual absence of Ca(2+) waves in arteries with myogenic tone. D-609, an inhibitor of PC-PLC and sphingomyelin synthase, strongly inhibited myogenic tone and had no effect on depolarization-induced contraction. D-609 appeared to act by lowering cytoplasmic Ca(2+) concentration to levels below those that activate contraction. Importantly, incubation of pressurized arteries with a membrane-permeable analog of DAG induced vasoconstriction. The results therefore mandate a reexamination of the signaling pathways activated by the Bayliss mechanism. Our results suggest that PI-PLC and IP3 are not required in maintaining myogenic tone, but DAG, produced by PC-PLC and/or SM synthase, is likely through multiple mechanisms to increase Ca(2+) entry and promote vasoconstriction.

  6. Niflumic Acid Attenuated Pulmonary Artery Tone and Vascular Structural Remodeling of Pulmonary Arterial Hypertension Induced by High Pulmonary Blood Flow In Vivo. (United States)

    Wang, Kai; Ma, Jianfa; Pang, Yusheng; Lao, Jinquan; Pan, Xuanren; Tang, Qiaoyun; Zhang, Feng; Su, Danyan; Qin, Suyuan; Shrestha, Arnav Prasad


    Calcium-activated chloride channels (CaCCs) play a vital role in regulating pulmonary artery tone during pulmonary arterial hypertension (PAH) induced by high blood flow. The role of CaCCs inhibitor niflumic acid (NFA) in vivo during this process requires further investigation. We established the PAH model by abdominal shunt surgery and treated with NFA in vivo. Fifty rats were randomly divided into normal, sham, shunt, NFA group 1 (0.2 mg/kg), and NFA group 2 (0.4 mg/kg). Pathological changes, right ventricle hypertrophy index, arterial wall area/vessel area, and arterial wall thickness/vessel external diameter were analyzed. Then contraction reactions of pulmonary arteries were measured. Finally, the electrophysiological characteristics of pulmonary arterial smooth muscle cells were investigated using patch-clamp technology. After 11 weeks of shunting, PAH developed, accompanied with increased right ventricle hypertrophy index, arterial wall area/vessel area, and arterial wall thickness/vessel external diameter. In the NFA treatment groups, the pressure and pathological changes were alleviated. The pulmonary artery tone in the shunt group increased, whereas it decreased after NFA treatment. The current density of CaCC was higher in the shunt group, and it was decreased in the NFA treatment groups. In conclusion, NFA attenuated pulmonary artery tone and structural remodeling in PAH induced by high pulmonary blood flow in vivo. CaCCs were involved and the augmented current density was alleviated by NFA treatment.

  7. Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity. (United States)

    Cipolla, Marilyn J; Sweet, Julie; Chan, Siu-Lung; Tavares, Matthew J; Gokina, Natalia; Brayden, Joseph E


    Brain parenchymal arterioles (PAs) are high-resistance vessels that branch off pial arteries and perfuse the brain parenchyma. PAs are the target of cerebral small vessel disease and have been shown to have greater pressure-induced tone at lower pressures than pial arteries. We investigated mechanisms by which brain PAs have increased myogenic tone compared with middle cerebral arteries (MCAs), focusing on differences in vascular smooth muscle (VSM) calcium and ion channel function. The amount of myogenic tone and VSM calcium was measured using Fura 2 in isolated and pressurized PAs and MCAs. Increases in intraluminal pressure caused larger increases in tone and cytosolic calcium in PAs compared with MCAs. At 50 mmHg, myogenic tone was 37 ± 5% for PAs vs. 6.5 ± 4% for MCAs (P channel (VDCC) inhibitor nifedipine than MCAs (EC50 for PAs was 3.5 ± 0.4 vs. 82.1 ± 2.1 nmol/l for MCAs;P channel inhibitor iberiotoxin, whereas MCAs constricted ∼15%. Thus increased myogenic tone in PAs appears related to differences in ion channel activity that promotes VSM membrane depolarization but not to a direct sensitization of the contractile apparatus to calcium.

  8. Closure of digital arteries in high vascular tone states as demonstrated by measurement of systolic blood pressure in the fingers

    DEFF Research Database (Denmark)

    Krähenbühl, B; Nielsen, S L; Lassen, N A


    Finger systolic blood pressure (FSP) was measured indirectly in normal subjects and patients with primary Raynaud phenomenon by applying a thin-walled plastic cuff around the finger and a strain gauge more distally to detect volume changes. Inducing a high vascular tone in one or more fingers...... by direct cooling or intra-arterial noradrenaline infusion caused a marked drop in FSP in the exposed fingers, but not in the non-exposed fingers of the same hand. The fact that the non-exposed fingers retained the normal (arm systolic) pressure level is taken to indicate that palmar arch blood pressure...... also remained normal. In the high vascular tone state, a large transmural pressure difference must apparently be established before the digital arteries are forced open. The lowered opening pressure constitutes a manifestation of the closure phenomenon of the digital arteries described in patients...

  9. Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone

    DEFF Research Database (Denmark)

    Jepps, Thomas A; Carr, Georgina; Lundegaard, Pia R;


    tone by Kv7 channels. In HEK cells expressing Kv7.4, co-expression of KCNE4 increased the membrane expression of Kv7.4 and significantly altered Kv7.4 current properties. Quantitative PCR analysis of different rat arteries found that the KCNE4 isoform predominated and proximity ligation experiments......), which coincided with impaired effects of Kv7 modulators. When KCNE4 expression was reduced, less Kv7.4 expression was found in the membrane of the mesenteric artery myocytes. These data show that KCNE4 is consistently expressed in a variety of arteries, and knockdown of the expression product leads...

  10. Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia.

    Directory of Open Access Journals (Sweden)

    Gaoliang Yan

    Full Text Available AIMS: Arachidonic acid (AA and its metabolites, prostaglandins (PG are known to be involved in regulation of vascular homeostasis including vascular tone and vessel wall tension, but their potential role in Hypoxic pulmonary vasoconstriction (HPV remains unclear. In this study, we examined the effects of AA and PGE2 on the hypoxic response in isolated rat intrapulmonary arteries (IPAs. METHODS AND RESULTS: We carried out the investigation on IPAs by vessel tension measurement. Isotetrandrine (20 µM significantly inhibited phase I, phase IIb and phase IIc of hypoxic vasoconstriction. Both indomethacin (100 µM and NS398 attenuated KPSS-induced vessel contraction and phase I, phase IIb and phase IIc of HPV, implying that COX-2 plays a primary role in the hypoxic response of rat IPAs. PGE2 alone caused a significant vasoconstriction in isolated rat IPAs. This constriction is mediated by EP4. Blockage of EP4 by L-161982 (1 µM significantly inhibited phase I, phase IIb and phase IIc of hypoxic vasoconstriction. However, AH6809 (3 µM, an antagonist of EP1, EP2, EP3 and DP1 receptors, exerted no effect on KPSS or hypoxia induced vessel contraction. Increase of cellular cAMP by forskolin could significantly reduce KPSS-induced vessel contraction and abolish phase I, phase II b and phase II c of HPV. CONCLUSION: Our results demonstrated a vasoconstrictive effect of PGE2 on rat IPAs and this effect is via activation of EP4. Furthermore, our results suggest that intracellular cAMP plays dual roles in regulation of vascular tone, depending on the spatial distribution of cAMP and its coupling with EP receptor and Ca(2+ channels.

  11. Role of Adenosine Receptor(s) in the Control of Vascular Tone in the Mouse Pudendal Artery. (United States)

    Labazi, Hicham; Tilley, Stephen L; Ledent, Catherine; Mustafa, S Jamal


    Activation of adenosine receptors (ARs) has been implicated in the modulation of renal and cardiovascular systems, as well as erectile functions. Recent studies suggest that adenosine-mediated regulation of erectile function is mainly mediated through A2BAR activation. However, no studies have been conducted to determine the contribution of AR subtype in the regulation of the vascular tone of the pudendal artery (PA), the major artery supplying and controlling blood flow to the penis. Our aim was to characterize the contribution of AR subtypes and identify signaling mechanisms involved in adenosine-mediated vascular tone regulation in the PA. We used a DMT wire myograph for muscle tension measurements in isolated PAs from wild-type, A2AAR knockout, A2BAR knockout, and A2A/A2BAR double-knockout mice. Real-time reverse transcription-polymerase chain reaction was used to determine the expression of the AR subtypes. Data from our pharmacologic and genetic approaches suggest that AR activation-mediated vasodilation in the PA is mediated by both the A2AAR and A2BAR, whereas neither the A1AR nor A3AR play a role in vascular tone regulation of the PA. In addition, we showed that A2AAR- and A2BAR-mediated vasorelaxation requires activation of nitric oxide and potassium channels; however, only the A2AAR-mediated response requires protein kinase A activation. Our data are complemented by mRNA expression showing the expression of all AR subtypes with the exception of the A3AR. AR signaling in the PA may play an important role in mediating erection and represent a promising therapeutic option for the treatment of erectile dysfunction.

  12. Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries

    DEFF Research Database (Denmark)

    VanBavel, Ed; Sorop, Oana; Andreasen, Ditte;


    myogenic tone compared with K(+)-induced constriction [log(IC(50), M): mibefradil, basal -7.3 +/- 0.2 (n = 9) and K(+) -5.1 +/- 0.1 (n = 5); nickel, basal -4.1 +/- 0.2 (n = 5) and K(+) -1.6 +/- 0.5 (n = 5); means +/- SE]. Verapamil had a 17-fold more potent effect [log(IC(50), M): basal -6.6 +/- 0.1 (n = 5......); K(+) -5.4 +/- 0.3 (n = 4); all log(IC(50)) P

  13. Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

    DEFF Research Database (Denmark)

    Howitt, Lauren; Kuo, Ivana Y; Ellis, Anthie;


    AIMS: As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our aim was to determine the impact of this change on the mechanism underlying vascular tone of pressurized arteries in vitro and in vivo. METHODS AND RESULTS: We used pressurized cerebral and mesenteric......, by regulating the bioavailability of reactive oxygen species produced by NADPH oxidase. Our data provide evidence for a novel causal link between nitric oxide deficit, oxidative stress, and T-type calcium channel function....


    Institute of Scientific and Technical Information of China (English)


    Introduction In teaching writing, people usually pay attention to grammatical problems from sentence structure to articles. They also pay attention to spelling, capitalisation, punctuation and the choice of words. These are essential-but so is the tone of the writing. In this article, I’d like to present some ideas about tone. Tone

  15. Two Tones

    DEFF Research Database (Denmark)

    Palludan, Charlotte


    This article examines how kindergarten-children are differentiated and segregated through vocal practices and processes. The analysis is based on empirical data, which originate from a long ethnographic fieldwork in Denmark. The author presents two different language tones: "a teaching tone...... and an exchange tone" and shows a pattern in the ways the two tones are performed. While the teaching tone is heard in the interaction between the staff and the ethnic minority children, the ethnic majority children (the Danes) are addressed in the exchange tone. Pierre Bourdieu's concepts: "linguistic market......", "habitual inclinations" and "feeling for the game" are used as theoretical framework. When the author interprets and explains the language pattern as unequal distribution of recognition and as continuation of reproduction of a socio-cultural hierarchy among the children she relates to this framework...

  16. Contour Tones. (United States)

    Yip, Moira


    Argues that contour tones in East Asian languages behave as melodic units consisting of a root node [upper] dominating a branching specification. It is also argued that, with upper as the tonal root node, no more than two rising or falling tones will contrast underlying. (49 references) (JL)

  17. Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries.

    Directory of Open Access Journals (Sweden)

    Debebe Gebremedhin

    Full Text Available The present study examined the level of generation of reactive oxygen species (ROS and roles of inactivation of the phosphatase PTEN and the PI3K/Akt signaling pathway in response to an increase in intramural pressure-induced myogenic cerebral arterial constriction. Step increases in intraluminal pressure of cannulated cerebral arteries induced myogenic constriction and concomitant formation of superoxide (O2 (.- and its dismutation product hydrogen peroxide (H2O2 as determined by fluorescent HPLC analysis, microscopic analysis of intensity of dihydroethidium fluorescence and attenuation of pressure-induced myogenic constriction by pretreatment with the ROS scavenger 4,hydroxyl-2,2,6,6-tetramethylpiperidine1-oxyl (tempol or Mito-tempol or MitoQ in the presence or absence of PEG-catalase. An increase in intraluminal pressure induced oxidation of PTEN and activation of Akt. Pharmacological inhibition of endogenous PTEN activity potentiated pressure-dependent myogenic constriction and caused a reduction in NPo of a 238 pS arterial KCa channel current and an increase in [Ca(2+]i level in freshly isolated cerebral arterial muscle cells (CAMCs, responses that were attenuated by Inhibition of the PI3K/Akt pathway. These findings demonstrate an increase in intraluminal pressure induced increase in ROS production triggered redox-sensitive signaling mechanism emanating from the cross-talk between oxidative inactivation of PTEN and activation of the PI3K/Akt signaling pathway that involves in the regulation of pressure-dependent myogenic cerebral arterial constriction.

  18. Age-dependent impact of CaV3.2 T-type calcium channel deletion on myogenic tone and flow-mediated vasodilatation in small arteries

    DEFF Research Database (Denmark)

    Mikkelsen, Miriam F.; Björling, Karl; Jensen, Lars Jørn


    .2-dependent and -independent effects. No changes in mRNA expression of several important K(+) and Ca(2+) channel genes were induced by CaV3.2 knock-out. However, the expression of the other T-type channel isoform (CaV3.1) was reduced at the mRNA and protein level in mature adult compared to young WT arteries......The myogenic response and flow-mediated vasodilatation are important regulators of local blood perfusion and total peripheral resistance, and are known to entail a calcium influx into vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), respectively. CaV3.2 T-type calcium channels...... are expressed in both VSMCs and ECs of small arteries. The T-type channels are important drug targets but due to the lack of specific antagonists our understanding of the role of CaV3.2 channels in vasomotor tone at various ages is scarce. We evaluated the myogenic response, flow-mediated vasodilatation...

  19. Comparison of arterial pressure and plethysmographic waveform-based dynamic preload variables in assessing fluid responsiveness and dynamic arterial tone in patients undergoing major hepatic resection

    NARCIS (Netherlands)

    Vos, J. J.; Kalmar, A. F.; Struys, M. M. R. F.; Wietasch, J. K. G.; Hendriks, H. G. D.; Scheeren, T. W. L.


    Dynamic preload variables to predict fluid responsiveness are based either on the arterial pressure waveform (APW) or on the plethysmographic waveform (PW). We compared the ability of APW-based variations in stroke volume (SVV) and pulse pressure (PPV) and of PW-based plethysmographic variability in

  20. Drug-Free Correction of the Tone of the Autonomic Nervous System in the Management of Cardiac Arrhythmia in Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Sergey V. Popov, PhD, ScD


    Full Text Available Background: The aim of our study was to examine the possibility of ventricular extrasystole (VES management in CAD (coronary artery disease patients by attenuating the sympathetic activity with a course of electrical stimulation of the vagus nerve. Methods: A decrease in sympathetic tone was achieved via vagus nerve electrical stimulation (VNES. VNES was performed in 48 male CAD patients, mean age 53.5±4.1 years. Antiarrhythmic drug therapy was canceled prior to VNES therapy. The effect of VNES on heart rate variability (HRV and VES were carefully studied. All the patients received a 24-hour ECG monitoring. HRV was calculated for high frequency (HF and low frequency (LF bands and the LF/HF index was determined. Results: Immediately following VNES therapy, 30 patients (group 1 reported alleviation of angina signs and the LF/HF index was significantly decreased (p=0.001. Eighteen patients (group 2 showed no change either in health or the LF/HF index. According to ECG and echocardiography, the VES number did not significantly change immediately after VNES therapy. One month after the VNES course, group 1 reported further improvement in health; the LF/HF index approached normal values. In group 2, the LF/HF significantly decreased (p=0.043. However, in the entire study sample, the VES number significantly decreased overall (p=0.025. Conclusion: VNES attenuated the cardiac effects of hypersympathicotonia decreased the ischemic impact on the myocardium, alleviated the cardiac angina signs, and beneficially influenced the VES number in CAD patients.

  1. Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure. (United States)

    Olea, Elena; Agapito, Maria Teresa; Gallego-Martin, Teresa; Rocher, Asuncion; Gomez-Niño, Angela; Obeso, Ana; Gonzalez, Constancio; Yubero, Sara


    Obstructive sleep apnea (OSA) consists of sleep-related repetitive obstructions of upper airways that generate episodes of recurrent or intermittent hypoxia (IH). OSA commonly generates cardiovascular and metabolic pathologies defining the obstructive sleep apnea syndrome (OSAS). Literature usually links OSA-associated pathologies to IH episodes that would cause an oxidative status and a carotid body-mediated sympathetic hyperactivity. Because cardiovascular and metabolic pathologies in obese patients and those with OSAS are analogous, we used models (24-wk-old Wistar rats) of IH (applied from weeks 22 to 24) and diet-induced obesity (O; animals fed a high-fat diet from weeks 12 to 24) to define the effect of each individual maneuver and their combination on the oxidative status and sympathetic tone of animals, and to quantify cardiovascular and metabolic parameters and their deviation from normality. We found that IH and O cause an oxidative status (increased lipid peroxides and diminished activities of superoxide dismutases), an inflammatory status (augmented C-reactive protein and nuclear factor kappa-B activation), and sympathetic hyperactivity (augmented plasma and renal artery catecholamine levels and synthesis rate); combined treatments worsened those alterations. IH and O augmented liver lipid content and plasma cholesterol, triglycerides, leptin, glycemia, insulin levels, and HOMA index, and caused hypertension; most of these parameters were aggravated when IH and O were combined. IH diminished ventilatory response to hypoxia, and hypercapnia and O created a restrictive ventilatory pattern; a combination of treatments led to restrictive hypoventilation. Data demonstrate that IH and O cause comparable metabolic and cardiovascular pathologies via misregulation of the redox status and sympathetic hyperactivity.

  2. 不同浓度依托咪酯对内毒素孵育前后兔离体肺、体动脉环张力的影响%Effect of different concentrations of etomidate on the tone of isolated rabbit pulmonary and aortic artery rings before and after LPS incubation

    Institute of Scientific and Technical Information of China (English)

    李玢琳; 张锦; 李娜; 佟冬怡


    Objective To observe the effects of etomidate on isolated rabbit pulmonary and aortic artery rings before and after LPS incubation, and provide evidence for narcotic choice of clinic septic shock. Methods The rings of pulmonary and aortic arteries were prepared and randomly divided into 4 groups: normal pulmonary artery rings group, LPS incubated pulmonary artery rings group, normal aortic artery rings group and LPS incubated aortic artery rings group. The effects of etomidate of 1. 0 μmol/L,2. 0 μmol/L, 10. 0 μmol/L on pulmonary and aortic arteries in two groups were observed when phenylephrine( PE )pre-contracting. Results The tone of pulmonary and aortic arteries be fore and after LPS incubated had no significant difference( P > 0. 05 )when 1. 0 μmol/L of etomidate was given; the tone of normal pulmonary and aortic arteries and LPS aortic arteries increased significantly( P 0.05);2.0 μmol/L时,正常肺、主动脉环和LPS孵育后主动脉环张力明显上升(P<0.05);10.0 μmol/L时,LPS孵育的肺、主动脉环的张力较正常肺、主动脉环明显下降(P<0.05).结论 低浓度Eto收缩机制占主导,但随着浓度增加,Eto引起内毒素孵育后肺动脉舒张的程度比体动脉更明显,可能与高浓度Eto抑制血管收缩功能有关.

  3. Propeller tone bursts (United States)

    Succi, G. P.; Munro, D. H.; Ingard, K. U.


    Intense high frequency (25-38 kHz) tone bursts have been observed in acoustic tests of a scale model of a general aviation propeller. The amplitude of the tone burst is approximately equal to the amplitude of the propeller noise signature. The conditions necessary for the production of these tone bursts are described. The experiments indicate that the origin of these bursts is a periodic flow oscillation on the suction surface of the propeller blade tips which may be due to the interaction between an oscillating shock wave and a laminar boundary layer.

  4. Automated tone transcription

    CERN Document Server

    Bird, S


    In this paper I report on an investigation into the problem of assigning tones to pitch contours. The proposed model is intended to serve as a tool for phonologists working on instrumentally obtained pitch data from tone languages. Motivation and exemplification for the model is provided by data taken from my fieldwork on Bamileke Dschang (Cameroon). Following recent work by Liberman and others, I provide a parametrised F_0 prediction function P which generates F_0 values from a tone sequence, and I explore the asymptotic behaviour of downstep. Next, I observe that transcribing a sequence X of pitch (i.e. F_0) values amounts to finding a tone sequence T such that P(T) {}~= X. This is a combinatorial optimisation problem, for which two non-deterministic search techniques are provided: a genetic algorithm and a simulated annealing algorithm. Finally, two implementations---one for each technique---are described and then compared using both artificial and real data for sequences of up to 20 tones. These programs ...

  5. Phonetics and Phonology of Chicahuaxtla Triqui Tones (United States)

    Matsukawa, Kosuke


    Chicahuaxtla Triqui (Otomanguean, Mexico) is one of the rare tone languages with five contrastive level tones and its underlying tone system is even more complicated than its surface five-level tone system. The complexity of its underlying tone system has developed through the historical tone shifts from Proto-Triqui. The surface tone system of…

  6. Contrastive tone in Kalam Kohistani

    Directory of Open Access Journals (Sweden)

    Joan L.G. Baart


    Full Text Available It has been observed that tonal phenomena occur in quite a few Indo-Aryan languages in the northwestern corner of the South-Asian subcontinent. This paper presents a study of the tone system of one of these languages, Kalam Kohistani. After establishing that Kalam Kohistani has five contrastive surface tones—a high tone, a low tone, a rising tone, and two types of falling tone—I propose an analysis of these tones in terms of Autosegmental Phonology. Furthermore, some observations are made on the relation between aspiration and tone, and on the functional load of tone in Kalam Kohistani. Its relatively rich inventory of tones makes Kalam Kohistani, along with two of its close neighbors, stand out as unique among the Indo-Aryan languages.

  7. Tone features in whispered Chinese

    Institute of Scientific and Technical Information of China (English)

    LI Xueli; XU Boling


    Study on the whispered tone is important to speech recognition and conversion in whispered Chinese. In this paper, the characteristics of whispered speech are introduced and the tone features in whispered Chinese are discussed. There is no fundamental frequency in the whispered speech, so other features, such as the amplitude envelope, duration, glottal area, lip area, forrnant, and vocal tract length, are extracted and their contributions to the automatic tone recognition are compared. From the experiments with six simple Chinese whispered vowels in four tones, it is proved that loudness-weighted 32 Mel-frequency bands log-amplitude envelopes and duration can be used as the main tone features in the whispered Chinese tone recognition. The average tone recognition rate approaches that of the human perception level.

  8. [Vasomotor tone and CBP : monitoring components, pratical and therapeutic approaches]. (United States)

    Isetta, C; Janot, N


    The vasomotor tone is an essential determinant of blood pressure. Vascular resistance is the result of a calculation including vasomotor tone, blood flow and blood viscosity. The vascular tone is modulated by the sympathetic system and the direct actions of drugs (patient's pathology, anaesthesia). The pressure and flow allow the vascular tone apprehension. A decrease in vasomotor tone lowers the mean arterial pressure and may cause an intense vasoplegia with arterial vascular resistance below than 800 dyn/s/cm(5) leading to a lack of tissue oxygenation. Vasomotor paralysis can be caused by the patient medications or an intense inflammatory reaction starting at the extracorporeal circulation onset. Monitoring parameters of extracorporeal circulation such as pressure, flow, arterial and venous oxygen saturation, blood level in the venous reservoir, and extensively blood gases, haemoglobin, CO(2) partial pressure level of the oxygenator vent, bispectral index, and oxygen saturation of cerebral tissue are reviewed. They will know the vasoplegia consequences and bear an indication of adequate tissue oxygenation. It may be obtained by using vasopressors (ephedrine, norepinephrine, terbutalin and vasopressin) methylene blue, increasing blood viscosity (erythrocytes) and blood flow, even by inducing hypothermia.

  9. Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats

    Energy Technology Data Exchange (ETDEWEB)

    Shimojo, G.L.; Palma, R.K.; Brito, J.O.; Sanches, I.C. [Laboratório de Fisiologia Translacional, Programa de Ciências da Reabilitação, Universidade Nove de Julho, São Paulo, SP (Brazil); Irigoyen, M.C. [Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); De Angelis, K. [Laboratório de Fisiologia Translacional, Programa de Ciências da Reabilitação, Universidade Nove de Julho, São Paulo, SP (Brazil)


    The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated with decreased vagal tone. Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as well as resting bradycardia (RTHO: 332±9.0 vs SHO: 356±5 bpm). Sympathetic tone was also lower in the trained group. Moreover, sympathetic tone was positively correlated with resting HR (r=0.7, P<0.05). The additional arterial pressure increase in hypertensive rats caused by ovarian hormone deprivation was attenuated by moderate-intensity dynamic resistance training. This benefit may be associated with resting bradycardia and reduced cardiac sympathetic tone after training, which suggests potential benefits of resistance exercise for the management of hypertension after ovarian hormone deprivation.

  10. Strategies for Analyzing Tone Languages (United States)

    Coupe, Alexander R.


    This paper outlines a method of auditory and acoustic analysis for determining the tonemes of a language starting from scratch, drawing on the author's experience of recording and analyzing tone languages of north-east India. The methodology is applied to a preliminary analysis of tone in the Thang dialect of Khiamniungan, a virtually undocumented…

  11. Tone compatibility between HDR displays (United States)

    Bist, Cambodge; Cozot, Rémi; Madec, Gérard; Ducloux, Xavier


    High Dynamic Range (HDR) is the latest trend in television technology and we expect an in ux of HDR capable consumer TVs in the market. Initial HDR consumer displays will operate on a peak brightness of about 500-1000 nits while in the coming years display peak brightness is expected to go beyond 1000 nits. However, professionally graded HDR content can range from 1000 to 4000 nits. As with Standard Dynamic Range (SDR) content, we can expect HDR content to be available in variety of lighting styles such as low key, medium key and high key video. This raises concerns over tone-compatibility between HDR displays especially when adapting to various lighting styles. It is expected that dynamic range adaptation between HDR displays uses similar techniques as found with tone mapping and tone expansion operators. In this paper, we survey simple tone mapping methods of 4000 nits color-graded HDR content for 1000 nits HDR displays. We also investigate tone expansion strategies when HDR content graded in 1000 nits is displayed on 4000 nits HDR monitors. We conclude that the best tone reproduction technique between HDR displays strongly depends on the lighting style of the content.

  12. Tone and inflection: An introduction


    Palancar, Enrique L.; Léonard, Jean-Léo


    Accepted in Enrique L. Palancar & Jean-Léo Léonard (eds.), Tone and Inflection: New facts under new perspectives. Submitted to DeGruyter, Oct. 2014; Tone is about melody and meaning, inflection is about grammar and this book is about a bit of both. The different papers in this book study possible and sometimes very complex ways in which the melodies of a given language engage in the expression of grammatical meaning. In this light, the volume aims to broaden our understanding of the role of t...

  13. The effect of small dose propofol on the tone of rabbit pulmonary artery and chest aorta after LPS induction%小剂量异丙酚对内毒素孵育兔肺动脉及体动脉血管的影响

    Institute of Scientific and Technical Information of China (English)

    来源; 张锦


    目的:观察小剂量异丙酚(Propofol,PF)对内毒素(LPS)致感染性休克兔外周血管阻力(SVR)、阻力指数(SVRI)、胸腔液体量(TFC)以及离体肺动脉环和胸主动脉环张力的影响。研究小剂量异丙酚对感染性休克兔的保护作用及可能机制。方法选择健康成年雄性大耳兔20只,体重2.5~2.8kg,随机分为正常组(N组)和LPS 致休克模型组(L组),再以两种不同小剂量(50μmol/L和100μmol/L)异丙酚对两组分别进行干预,每项干预5只。用胸电生物阻抗法血液动力学连续监护系统(Bioz)测量各组SVR、SVRI和TFC,之后制备离体肺动脉环和主动脉环,连接张力换能器,观察各组血管环张力的变化。结果干预前与N组相比,L组SVR、SVRI下降,TFC升高(P<0.05),肺动脉环张力有所下降,但不如主动脉环张力下降明显(P<0.05)。与干预前相比,L组SVR、SVRI均有所升高(P<0.05),100μmol/L剂量下同时还伴有TFC下降(P<0.05)。离体条件下50μmol/L剂量时仅增加主动脉环对PE的反应性(P<0.05),100μmol/L剂量下在增加主动脉张力的同时,还能降低肺动脉张力,使肺动脉与主动脉环张力比值(P/A 值)降低(P<0.05)。结论小剂量异丙酚(50μmol/L 和100μmol/L)通过直接作用于血管壁调节血管张力,增加感染性休克兔主动脉血管张力,维持体循环稳定。其中100μmol/L的PF不但增加主动脉张力,还能降低肺动脉张力,更能有效纠正血管舒缩状态,改善组织灌注,对感染性休克兔的血管具有保护作用。%Objective To observe the effect of propofol (PF) in small dose on the tone of alive rabbit systemic vascular resistance/index (SVR/SVRI),thoracic fluid content (TFC) and isolated rabbit pulmonary artery and chest aorta rings before and after LPS (lipopolysaccharide) incubation, approach the protection function and possible

  14. Increased sympathetic tone in forearm subcutaneous tissue in primary hypothyroidism

    DEFF Research Database (Denmark)

    Vagn Nielsen, H; Hasselström, K; Feldt-Rasmussen, U


    Sympathetic reflex regulation of subcutaneous blood flow (SBF) in the forearm was studied in eight patients with primary hypothyroidism. Diastolic arterial pressure was greater than or equal to 95 mmHg in five patients. SBF was determined by local clearance of Na99mTcO4. Sympathetic vasoconstrict......Sympathetic reflex regulation of subcutaneous blood flow (SBF) in the forearm was studied in eight patients with primary hypothyroidism. Diastolic arterial pressure was greater than or equal to 95 mmHg in five patients. SBF was determined by local clearance of Na99mTcO4. Sympathetic.......02)). In conclusion sympathetic vasoconstrictor activity in adipose tissue is markedly increased in primary hypothyroidism. Sympathetic tone and arterial pressure are reduced during treatment....

  15. Root Tone: A Holistic Approach to Tone Pedagogy of Western Classical Flute (United States)

    BastaniNezhad, Arya


    This article examines how key components of holistic tone production can help flutists form a resonant tone. This is framed in an exploration of tone pedagogy and includes a model of tone evaluation and education. This research is also applicable to other instrumentalists, especially wind players. In this case study information was collected by…

  16. Perception of Mandarin Chinese Tone 2/Tone 3 and the Role of Creaky Voice (United States)

    Cao, Rui


    Research has shown that lexical tones, a suprasegmental feature, are processed by native speakers as linguistic elements just like other segmental information. Among the four tones of Mandarin Chinese, in particular, Tone 2 and Tone 3 are very similar in their pitch contour shapes and thus can be difficult to distinguish in native and nonnative…

  17. Designing Tone Reservation PAR Reduction

    Directory of Open Access Journals (Sweden)

    Johansson Albin


    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  18. Regulation of vascular tone by adipocytes

    Directory of Open Access Journals (Sweden)

    Van de Voorde Johan


    Full Text Available Abstract Recent studies have shown that adipose tissue is an active endocrine and paracrine organ secreting several mediators called adipokines. Adipokines include hormones, inflammatory cytokines and other proteins. In obesity, adipose tissue becomes dysfunctional, resulting in an overproduction of proinflammatory adipokines and a lower production of anti-inflammatory adipokines. The pathological accumulation of dysfunctional adipose tissue that characterizes obesity is a major risk factor for many other diseases, including type 2 diabetes, cardiovascular disease and hypertension. Multiple physiological roles have been assigned to adipokines, including the regulation of vascular tone. For example, the unidentified adipocyte-derived relaxing factor (ADRF released from adipose tissue has been shown to relax arteries. Besides ADRF, other adipokines such as adiponectin, omentin and visfatin are vasorelaxants. On the other hand, angiotensin II and resistin are vasoconstrictors released by adipocytes. Reactive oxygen species, leptin, tumour necrosis factor α, interleukin-6 and apelin share both vasorelaxing and constricting properties. Dysregulated synthesis of the vasoactive and proinflammatory adipokines may underlie the compromised vascular reactivity in obesity and obesity-related disorders.

  19. The effect of neuropeptides on vessel tone and cAMP production

    DEFF Research Database (Denmark)

    Yao, W; Sheikh, S P; Ottesen, B;


    The effect of VIP, PHM, PHV, PACAP-27, and PACAP-38 on vessel tone and cAMP production was investigated in rabbit ovarian arteries in vitro. The peptides (10(-7)M) induced a significant relaxation on NA-precontracted vessels and displayed similar potencies. The cAMP accumulation induced by PACAP-...

  20. Adaptation of active tone in the mouse descending thoracic aorta under acute changes in loading. (United States)

    Murtada, S-I; Lewin, S; Arner, A; Humphrey, J D


    Arteries can adapt to sustained changes in blood pressure and flow, and it is thought that these adaptive processes often begin with an altered smooth muscle cell activity that precedes any detectable changes in the passive wall components. Yet, due to the intrinsic coupling between the active and passive properties of the arterial wall, it has been difficult to delineate the adaptive contributions of active smooth muscle. To address this need, we used a novel experimental-computational approach to quantify adaptive functions of active smooth muscle in arterial rings excised from the proximal descending thoracic aorta of mice and subjected to short-term sustained circumferential stretches while stimulated with various agonists. A new mathematical model of the adaptive processes was derived and fit to data to describe and predict the effects of active tone adaptation. It was found that active tone was maintained when the artery was adapted close to the optimal stretch for maximal active force production, but it was reduced when adapted below the optimal stretch; there was no significant change in passive behavior in either case. Such active adaptations occurred only upon smooth muscle stimulation with phenylephrine, however, not stimulation with KCl or angiotensin II. Numerical simulations using the proposed model suggested further that active tone adaptation in vascular smooth muscle could play a stabilizing role for wall stress in large elastic arteries.

  1. The Phonology and Phonetics of Tone Perception (United States)

    Ramadoss, Deepti


    This dissertation studies the perception of tones in Thai, and aims to contribute to a formal characterization of speech perception more generally. Earlier work had argued that perception of tones involves retrieval of some abstract "autosegmental" representation provided by the phonology, while another line of work had argued for the…

  2. Recovering Asynchronous Watermark Tones from Speech (United States)


    Audio steganography for covert data transmission by impercep- tible tone insertion,” Proceedings Communications Sys- tems and Applications, IEEE, vol. 4, pp. 1647–1653, 2004. 1408 a comfortable margin. Index Terms— Speech Watermarking, Hidden Tones, Speech Steganography , Speech Data Hiding 1. BACKGROUND Imperceptibly

  3. Effets du fluor et du phosphogypse chez les organismes marins


    Martin, J.L.; Le Guellec, Anne-marie; Cosson, R.


    Dans le cadre général des recherches visant à déterminer l'action des effluents industriels et plus précisément du fluor dans le cas de cette étude, le programme dont les résultats sont présentés avait pour but de déterminer les effets de cet élément sur les organismes marins. Trois aspects essentiels ont été envisagés : - Effets létaux du fluor ; - effets du fluor sur certaines fonctions éthologiques ; - bio-accumulation de l'élément par les organismes marins.

  4. Perception and production of tone in aphasia. (United States)

    Gandour, J; Petty, S H; Dardarananda, R


    An acoustical and perceptual study of lexical tone was conducted to evaluate the extent and nature of tonal disruption in aphasia. The language under investigation was Thai, a tone language which has five lexical tones--mid, low, falling, high, and rising. Subjects included six left brain-damaged aphasics (two Broca's, one transcortical motor, one global, one conduction, one Wernicke), one right brain-damaged nonaphasic, one cerebellar dysarthric, and five normals. High-quality tape recordings of each subject's productions of a minimal set of five, monosyllabic Thai words were presented to 10 adult Thai listeners for identification. Results from the phonemic identification tests indicated that tone production is relatively spared in aphasic patients with unilateral left hemisphere lesions. The performance of the global aphasic, however, was considerably below normal. Patterns of tonal confusions further revealed that the performance of all aphasics, except the global, differed from that of normal speakers primarily in degree rather than in kind. Tonal contrasts were signaled at a high level of proficiency by the right brain-damaged and dysarthric patients. Acoustical analysis revealed that F0 contours associated with the five tones for all aphasics, except the global, were similar in overall shape as well as position in the tone space to those of normals. F0 contours for the right brain-damaged patient and the dysarthric also generally agreed with those of normals in terms of shape and position. F0 ranges of both aphasic and nonaphasic brain-damaged speakers were generally larger than those of normals for all five tones. The relationship between tone and vowel duration was generally similar to that of normals for all brain-damaged speakers. A comparison of aphasics' performance on tone perception (J. Gandour & R. Dardarananda, 1983, Brain and Language, 18, 94-114) and tone production indicated that, for the normal and right brain-damaged subjects, performance on

  5. Effets perturbateurs endocriniens des pesticides organochlores. (United States)

    Charlier, C; Plomteux, G


    Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism, or to compete with estradiol for binding to the estrogen receptor, it may be possible that these products affect the risk of developing impaired fertility, precocious puberty or some kinds of cancer in man. Le plus ancien récit de lutte contre la pollution remonte à une légende indienne racontant que la divinité Sing-bonga était incommodée par les émanations des fours dans lesquels les Asuras fondaient leurs métaux (1). Evidemment depuis, la problématique n-a cessé de s-accroître et la contamination de la Terre par de nombreux polluants est devenue aujourd-hui un problème majeur de notre Société. La protection de notre environnement est une question capitale qui doit être respectée malgré la pression économique actuelle et qui ne cessera de croître au cours des prochaines années même si l-identification objective et indiscutable de ce qui est essentiel - donc devant être prioritairement garanti sur la planète - est difficile à cerner (2). « Un oiseau en mauvais état ne pond pas de bons oeufs » disait un proverbe grec. Mais ce n-est qu-à partir de la seconde moitié du XXème siècle que les toxicologues ont commencé à identifier les effets qu-avaient entraînés à l-échelle mondiale les pollutions émises aux XIXème siècle sur la faune sauvage et sur le cheptel (3). L-histoire contemporaine des pesticides industriels commence vers 1874 (synthèse des organochlorés) et se poursuit tout au long de ces 2 siècles en passant par la synthèse des organophosphorés (1950), des carbamates (1970) et des pyréthroïdes (1975) (4). Le dichlorodiphényltrichloroéthane (DDT) a été synthétisé pour la première fois par un étudiant en cours de préparation de sa thèse de doctorat : Othmer Zeidler. La production, reprise par les

  6. Computational Support for Early Elicitation and Classification of Tone (United States)

    Bird, Steven; Lee, Haejoong


    Investigating a tone language involves careful transcription of tone on words and phrases. This is challenging when the phonological categories--the tones or melodies--have not been identified. Effects such as coarticulation, sandhi, and phrase-level prosody appear as obstacles to early elicitation and classification of tone. This article presents…

  7. Estimation of cerebral vascular tone during exercise; evaluation by critical closing pressure in humans

    DEFF Research Database (Denmark)

    Ogoh, Shigehiko; Brothers, R Matthew; Jeschke, Monica;


    The aim of the present study was to calculate critical closing pressure (CCP) of the cerebral vasculature at rest and during exercise to estimate cerebral vascular tone. Five men and two women were seated upright for 15 min and then performed 15 min of right-legged knee extension exercise at 40, 60...... and 75% of their maximal workload (WL(max)). Middle cerebral artery blood velocity (MCA V) and blood pressure in the radial artery were recorded. The CCP was calculated by linear extrapolation from 1 min recordings of pairs of systolic and diastolic pressure and MCA V waveforms from both the right...

  8. Studying Emergent Tone-Systems in Nepal: Pitch, Phonation and Word-Tone in Tamang (United States)

    Mazaudon, Martine


    This paper focuses on the particular kinds of difficulties which arise in the study of an emergent tone-system, exemplified by Tamang in Nepal, where pitch, phonation and other laryngeal features combine in the definition of a tone. As a consequence, conducting a well-ordered analysis in stages first of phonetic transcription, then variation in…

  9. Perception of tones by infants learning a non-tone language

    NARCIS (Netherlands)

    Kager, René; Liu, Liquan


    This article examines the perception of tones by non-tone-language-learning (non-tonelearning) infants between 5 and 18 months in a study that reveals infants’ initial sensitivity to tonal contrasts, deterioration yet plasticity of tonal sensitivity at the end of the first year, and a perceptual reb

  10. Direct Numerical Simulation of Automobile Cavity Tones (United States)

    Kurbatskii, Konstantin; Tam, Christopher K. W.


    The Navier Stokes equation is solved computationally by the Dispersion-Relation-Preserving (DRP) scheme for the flow and acoustic fields associated with a laminar boundary layer flow over an automobile door cavity. In this work, the flow Reynolds number is restricted to R(sub delta*) < 3400; the range of Reynolds number for which laminar flow may be maintained. This investigation focuses on two aspects of the problem, namely, the effect of boundary layer thickness on the cavity tone frequency and intensity and the effect of the size of the computation domain on the accuracy of the numerical simulation. It is found that the tone frequency decreases with an increase in boundary layer thickness. When the boundary layer is thicker than a certain critical value, depending on the flow speed, no tone is emitted by the cavity. Computationally, solutions of aeroacoustics problems are known to be sensitive to the size of the computation domain. Numerical experiments indicate that the use of a small domain could result in normal mode type acoustic oscillations in the entire computation domain leading to an increase in tone frequency and intensity. When the computation domain is expanded so that the boundaries are at least one wavelength away from the noise source, the computed tone frequency and intensity are found to be computation domain size independent.

  11. Enhanced visual perception through tone mapping (United States)

    Harrison, Andre; Mullins, Linda L.; Raglin, Adrienne; Etienne-Cummings, Ralph


    Tone mapping operators compress high dynamic range images to improve the picture quality on a digital display when the dynamic range of the display is lower than that of the image. However, tone mapping operators have been largely designed and evaluated based on the aesthetic quality of the resulting displayed image or how perceptually similar the compressed image appears relative to the original scene. They also often require per image tuning of parameters depending on the content of the image. In military operations, however, the amount of information that can be perceived is more important than the aesthetic quality of the image and any parameter adjustment needs to be as automated as possible regardless of the content of the image. We have conducted two studies to evaluate the perceivable detail of a set of tone mapping algorithms, and we apply our findings to develop and test an automated tone mapping algorithm that demonstrates a consistent improvement in the amount of perceived detail. An automated, and thereby predictable, tone mapping method enables a consistent presentation of perceivable features, can reduce the bandwidth required to transmit the imagery, and can improve the accessibility of the data by reducing the needed expertise of the analyst(s) viewing the imagery.

  12. Etude des effets du martelage repetitif sur les contraintes residuelles (United States)

    Hacini, Lyes

    L'assemblage par soudage peut engendrer des contraintes residuelles. Ces contraintes provoquent des fissurations prematurees et un raccourcissement de la duree de vie des composants. Dans ce contexte, le martelage robotise est utilise pour relaxer ces contraintes residuelles. Trois volets sont presentes: le premier est l'evaluation des effets des impacts unitaires repetes sur le champ de contraintes developpe dans des plaques d'acier inoxydable austenitique 304L vierges ou contenant des contraintes residuelles initiales. Dans la deuxieme partie de ce projet, le martelage est applique grace au robot SCOMPI. Les contraintes residuelles induites et relaxees par martelage sont ensuite mesurees par la methode des contours, qui a ete adaptee a cet effet. Dans la troisieme partie, le martelage est modelise par la methode des elements finis. Un modele axisymetrique developpe grace au logiciel ANSYS permet de simuler des impacts repetes d'un marteau elastique sur une plaque ayant un comportement elastoplastique.

  13. Arterial endothelial function measurement method and apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Maltz, Jonathan S; Budinger, Thomas F


    A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

  14. Collaborative Documentation and Revitalization of Cherokee Tone (United States)

    Herrick, Dylan; Berardo, Marcellino; Feeling, Durbin; Hirata-Edds, Tracy; Peter, Lizette


    Cherokee, the sole member of the southern branch of Iroquoian languages, is a severely endangered language. Unlike other members of the Iroquoian family, Cherokee has lexical tone. Community members are concerned about the potential loss of their language, and both speakers and teachers comment on the difficulty that language learners have with…

  15. Local adaptive tone mapping for video enhancement (United States)

    Lachine, Vladimir; Dai, Min (.


    As new technologies like High Dynamic Range cameras, AMOLED and high resolution displays emerge on consumer electronics market, it becomes very important to deliver the best picture quality for mobile devices. Tone Mapping (TM) is a popular technique to enhance visual quality. However, the traditional implementation of Tone Mapping procedure is limited by pixel's value to value mapping, and the performance is restricted in terms of local sharpness and colorfulness. To overcome the drawbacks of traditional TM, we propose a spatial-frequency based framework in this paper. In the proposed solution, intensity component of an input video/image signal is split on low pass filtered (LPF) and high pass filtered (HPF) bands. Tone Mapping (TM) function is applied to LPF band to improve the global contrast/brightness, and HPF band is added back afterwards to keep the local contrast. The HPF band may be adjusted by a coring function to avoid noise boosting and signal overshooting. Colorfulness of an original image may be preserved or enhanced by chroma components correction by means of saturation function. Localized content adaptation is further improved by dividing an image to a set of non-overlapped regions and modifying each region individually. The suggested framework allows users to implement a wide range of tone mapping applications with perceptional local sharpness and colorfulness preserved or enhanced. Corresponding hardware circuit may be integrated in camera, video or display pipeline with minimal hardware budget

  16. Problems in the Acquisition of Grammatical Tone. (United States)

    Demuth, Katherine

    An autosegmental account of the child's acquisition of grammatical tone in Sesotho, a southern Bantu language, is presented. The following theoretical questions are addressed: (1) When and how does the child figure out that Sesotho is a tonal rather than intonational, stress, or accentual language?; (2) How does the child acquire tonal rules?; and…

  17. The value of visualizing tone of voice. (United States)

    Pullin, Graham; Cook, Andrew


    Whilst most of us have an innate feeling for tone of voice, it is an elusive quality that even phoneticians struggle to describe with sufficient subtlety. For people who cannot speak themselves this can have particularly profound repercussions. Augmentative communication often involves text-to-speech, a technology that only supports a basic choice of prosody based on punctuation. Given how inherently difficult it is to talk about more nuanced tone of voice, there is a risk that its absence from current devices goes unremarked and unchallenged. Looking ahead optimistically to more expressive communication aids, their design will need to involve more subtle interactions with tone of voice-interactions that the people using them can understand and engage with. Interaction design can play a role in making tone of voice visible, tangible, and accessible. Two projects that have already catalysed interdisciplinary debate in this area, Six Speaking Chairs and Speech Hedge, are introduced together with responses. A broader role for design is advocated, as a means to opening up speech technology research to a wider range of disciplinary perspectives, and also to the contributions and influence of people who use it in their everyday lives.

  18. Caliber-Persistent Artery

    Directory of Open Access Journals (Sweden)

    Sabrina Araújo Pinho Costa


    Full Text Available Caliber-persistent artery (CPLA of the lip is a common vascular anomaly in which a main arterial branch extends to the surface of the mucous tissue with no reduction in its diameter. It usually manifests as pulsatile papule, is easily misdiagnosed, and is observed more frequently among older people, suggesting that its development may involve a degenerative process associated with aging; CPLA is also characterized by the loss of tone of the adjacent supporting connective tissue. Although the diagnosis is clinical, high-resolution Doppler ultrasound is a useful noninvasive tool for evaluating the lesion. This report describes the case of a 58-year-old male patient who complained of a lesion of the lower lip with bleeding and recurrent ulceration. The patient was successfully treated in our hospital after a diagnosis of CPLA and is currently undergoing a clinical outpatient follow-up with no complaints.

  19. A crosslinguistic PET study of tone perception. (United States)

    Gandour, J; Wong, D; Hsieh, L; Weinzapfel, B; Van Lancker, D; Hutchins, G D


    In studies of pitch processing, a fundamental question is whether shared neural mechanisms at higher cortical levels are engaged for pitch perception of linguistic and nonlinguistic auditory stimuli. Positron emission tomography (PET) was used in a crosslinguistic study to compare pitch processing in native speakers of two tone languages (that is, languages in which variations in pitch patterns are used to distinguish lexical meaning), Chinese and Thai, with those of English, a nontone language. Five subjects from each language group were scanned under three active tasks (tone, pitch, and consonant) that required focused-attention, speeded-response, auditory discrimination judgments, and one passive baseline as silence. Subjects were instructed to judge pitch patterns of Thai lexical tones in the tone condition; pitch patterns of nonspeech stimuli in the pitch condition; syllable-initial consonants in the consonant condition. Analysis was carried out by paired-image subtraction. When comparing the tone to the pitch task, only the Thai group showed significant activation in the left frontal operculum. Activation of the left frontal operculum in the Thai group suggests that phonological processing of suprasegmental as well as segmental units occurs in the vicinity of Broca's area. Baseline subtractions showed significant activation in the anterior insular region for the English and Chinese groups, but not Thai, providing further support for the existence of possibly two parallel, separate pathways projecting from the temporo-parietal to the frontal language area. More generally, these differential patterns of brain activation across language groups and tasks support the view that pitch patterns are processed at higher cortical levels in a top-down manner according to their linguistic function in a particular language.

  20. Stress and Tone in Indo-Aryan Languages (United States)

    Dhillon, Rajdip Kaur


    The current work offers a comprehensive examination of stress and tone in ten Indo-Aryan languages, providing novel analyses within Optimality Theory. The languages are divided into three categories: those in which tone is attracted to stress; those in which stress is attracted to tone; and those in which no interaction between stress and tone…

  1. Increased rhythmicity in hypertensive arterial smooth muscle is linked to transient receptor potential canonical channels

    DEFF Research Database (Denmark)

    Chen, Xiaoping; Yang, Dachun; Ma, Shuangtao


    Vasomotion describes oscillations of arterial vascular tone due to synchronized changes of intracellular calcium concentrations. Since increased calcium influx into vascular smooth muscle cells from spontaneously hypertensive rats (SHR) has been associated with variances of transient receptor...

  2. Auditory streaming of tones of uncertain frequency, level, and duration. (United States)

    Chang, An-Chieh; Lutfi, Robert A; Lee, Jungmee


    Stimulus uncertainty is known to critically affect auditory masking, but its influence on auditory streaming has been largely ignored. Standard ABA-ABA tone sequences were made increasingly uncertain by increasing the sigma of normal distributions from which the frequency, level, or duration of tones were randomly drawn. Consistent with predictions based on a model of masking by Lutfi, Gilbertson, Chang, and Stamas [J. Acoust. Soc. Am. 134, 2160-2170 (2013)], the frequency difference for which A and B tones formed separate streams increased as a linear function of sigma in tone frequency but was much less affected by sigma in tone level or duration.

  3. Congenital amusia (or tone-deafness interferes with pitch processing in tone languages

    Directory of Open Access Journals (Sweden)

    Barbara eTillmann


    Full Text Available Congenital amusia is a neurogenetic disorder that affects music processing and that is ascribed to a deficit in pitch processing. We investigated whether this deficit extended to pitch processing in speech, notably the pitch changes used to contrast lexical tones in tonal languages. Congenital amusics and matched controls, all non-tonal language speakers, were tested for lexical tone discrimination in Mandarin Chinese (Experiment 1 and in Thai (Experiment 2. Tones were presented in pairs and participants were required to make same/different judgments. Experiment 2 additionally included musical analogs of Thai tones for comparison. Performance of congenital amusics was inferior to that of controls for all materials, suggesting a domain-general pitch-processing deficit. The pitch deficit of amusia is thus not limited to music, but may compromise the ability to process and learn tonal languages. Combined with acoustic analyses of the tone material, the present findings provide new insights into the nature of the pitch-processing deficit exhibited by amusics.

  4. Affective evaluation of simultaneous tone combinations in congenital amusia. (United States)

    Marin, Manuela M; Thompson, William Forde; Gingras, Bruno; Stewart, Lauren


    Congenital amusia is a neurodevelopmental disorder characterized by impaired pitch processing. Although pitch simultaneities are among the fundamental building blocks of Western tonal music, affective responses to simultaneities such as isolated dyads varying in consonance/dissonance or chords varying in major/minor quality have rarely been studied in amusic individuals. Thirteen amusics and thirteen matched controls enculturated to Western tonal music provided pleasantness ratings of sine-tone dyads and complex-tone dyads in piano timbre as well as perceived happiness/sadness ratings of sine-tone triads and complex-tone triads in piano timbre. Acoustical analyses of roughness and harmonicity were conducted to determine whether similar acoustic information contributed to these evaluations in amusics and controls. Amusic individuals' pleasantness ratings indicated sensitivity to consonance and dissonance for complex-tone (piano timbre) dyads and, to a lesser degree, sine-tone dyads, whereas controls showed sensitivity when listening to both tone types. Furthermore, amusic individuals showed some sensitivity to the happiness-major association in the complex-tone condition, but not in the sine-tone condition. Controls rated major chords as happier than minor chords in both tone types. Linear regression analyses revealed that affective ratings of dyads and triads by amusic individuals were predicted by roughness but not harmonicity, whereas affective ratings by controls were predicted by both roughness and harmonicity. We discuss affective sensitivity in congenital amusia in view of theories of affective responses to isolated chords in Western listeners.

  5. A fundamental residue pitch perception bias for tone language speakers (United States)

    Petitti, Elizabeth

    A complex tone composed of only higher-order harmonics typically elicits a pitch percept equivalent to the tone's missing fundamental frequency (f0). When judging the direction of residue pitch change between two such tones, however, listeners may have completely opposite perceptual experiences depending on whether they are biased to perceive changes based on the overall spectrum or the missing f0 (harmonic spacing). Individual differences in residue pitch change judgments are reliable and have been associated with musical experience and functional neuroanatomy. Tone languages put greater pitch processing demands on their speakers than non-tone languages, and we investigated whether these lifelong differences in linguistic pitch processing affect listeners' bias for residue pitch. We asked native tone language speakers and native English speakers to perform a pitch judgment task for two tones with missing fundamental frequencies. Given tone pairs with ambiguous pitch changes, listeners were asked to judge the direction of pitch change, where the direction of their response indicated whether they attended to the overall spectrum (exhibiting a spectral bias) or the missing f0 (exhibiting a fundamental bias). We found that tone language speakers are significantly more likely to perceive pitch changes based on the missing f0 than English speakers. These results suggest that tone-language speakers' privileged experience with linguistic pitch fundamentally tunes their basic auditory processing.

  6. First Language Attrition: An Investigation of Taiwanese Tones and Tone Sandhi (United States)

    Chang, Yufen


    First language (L1) attrition research focuses on syntactic and morphological deterioration in environments where L1 "attriters" rarely have contact with their L1, such as immigrants. There is no study that investigates L1 attrition in tones and in contexts where L1 can still be often heard. This study examines this attrition type in…

  7. Perception of touch quality in piano tones. (United States)

    Goebl, Werner; Bresin, Roberto; Fujinaga, Ichiro


    Both timbre and dynamics of isolated piano tones are determined exclusively by the speed with which the hammer hits the strings. This physical view has been challenged by pianists who emphasize the importance of the way the keyboard is touched. This article presents empirical evidence from two perception experiments showing that touch-dependent sound components make sounds with identical hammer velocities but produced with different touch forms clearly distinguishable. The first experiment focused on finger-key sounds: musicians could identify pressed and struck touches. When the finger-key sounds were removed from the sounds, the effect vanished, suggesting that these sounds were the primary identification cue. The second experiment looked at key-keyframe sounds that occur when the key reaches key-bottom. Key-bottom impact was identified from key motion measured by a computer-controlled piano. Musicians were able to discriminate between piano tones that contain a key-bottom sound from those that do not. However, this effect might be attributable to sounds associated with the mechanical components of the piano action. In addition to the demonstrated acoustical effects of different touch forms, visual and tactile modalities may play important roles during piano performance that influence the production and perception of musical expression on the piano.

  8. FFT-DMAC:a tone based DMAC protocol

    Institute of Scientific and Technical Information of China (English)

    Li Ying; Li Minglu; Shu Wei; Wu Minyou


    This paper presents the flip-flop tone (FFT) DMAC protocol, a tone based MAC protocol using directional antennas to solve the deafness problem, hidden terminal and exposed terminal problems simultaneously. It uses two pairs of flip-flop tones. The first pair of tone is to send omni-directionally to reach every neighboring node to announce the start and the end of communication, and therefore to alleviate the deafness problem. The second pair of tone is to send directionally towards the sender. It is used to solve the hidden terminal problem as well as the exposed terminal problem. Evaluation shows that FFT-DMAC can achieve better performance compared to the 802.11 and ToneDMAC protocol.

  9. Assessment of conduit artery vasomotion using photoplethysmography (United States)

    Kanders, Karlis; Grabovskis, Andris; Marcinkevics, Zbignevs; Aivars, Juris Imants


    Vasomotion is a spontaneous oscillation of vascular tone. The phenomenon has been observed in small arterioles and capillaries as well as in the large conduit arteries. The layer of smooth muscle cells that surrounds a blood vessel can spontaneously and periodically change its tension and thereby the arterial wall stiffness also changes. As the understanding of the phenomenon is still rather obscure, researchers would benefit from a low-cost and reliable investigation technique such as photoplethysmography (PPG). PPG is an optical blood pulsation measurement technique that can offer substantial information about the arterial stiffness. The aims of this pilot study were to evaluate the usefulness of the PPG technique in the research of vasomotion and to investigate vasomotion in the relatively large conduit arteries. Continuous 15 minute long measurements of posterior tibial artery wall stiffness were taken. Artery diameter, electrocardiogram, blood pressure and respiration were also simultaneously registered. Fast Fourier Transform power spectra were calculated to identify unique stiffness oscillations that did not correspond to fluctuations in the systemic parameters and thus would indicate vasomotion. We concluded that photoplethysmography is a convenient method for the research of the vasomotion in large arteries. Local stiffness parameter b/a is more accurate to use and easier to measure than the pulse wave velocity which describes stiffness of a segment of an artery. Conduit arteries might exhibit a low amplitude high frequency vasomotion ( 9 to 27 cycles per minute). Low frequency vasomotion is problematic to distinguish from the passive oscillations imposed by the arterial pressure.



    Gall, Andrew J.; Poremba, Amy; Blumberg, Mark S.


    In week-old rats, lesions of the dorsolateral pontine tegmentum (DLPT) and nucleus pontis oralis (PnO) have opposing effects on nuchal muscle tone. Specifically, pups with DLPT lesions exhibit prolonged bouts of nuchal muscle atonia (indicative of sleep) and pups with PnO lesions exhibit prolonged bouts of high nuchal muscle tone (indicative of wakefulness). Here we test the hypothesis that nuchal muscle tone is modulated, at least in part, by cholinergically mediated interactions between the...



    Narwaria, Manish; Perreira Da Silva, Matthieu; Le Callet, Patrick; Pépion, Romuald


    International audience; Tone mapping or range reduction is often used in High Dynamic Range (HDR) visual signal compression to take advantage of the existing image/video coding architectures. Thus, it is important to study the impact of tone mapping on the visual quality of decompressed HDR visual signals. To our knowledge, most of the existing studies focus only on the quality loss in the resultant low dynamic range (LDR) signal (obtained via tone mapping) and typically employ LDR displays f...

  12. Neuromagnetic responses to frequency modulation of a continuous tone. (United States)

    Hari, R; Mäkelä, J P


    Neuromagnetic responses to frequency modulation of a continuous tone were studied in nine subjects. The latencies of the transient responses increased and the amplitudes decreased with decreasing speed of modulation. The equivalent dipoles for modulation of a 1,000 Hz tone were slightly but statistically significantly anterior to the dipoles activated by modulation of a 500 Hz tone. The generation mechanisms of N100m are discussed.

  13. Auditory pre-attentive processing of Chinese tones

    Institute of Scientific and Technical Information of China (English)

    YANG Li-jun; CAO Ke-li; WEI Chao-gang; LIU Yong-zhi


    Background Chinese tones are considered important in Chinese discrimination.However,the relevant reports on auditory central mechanisms concerning Chinese tones are limited.In this study,mismatch negativity (MMN),one of the event related potentials (ERP),was used to investigate pre-attentive processing of Chinese tones,and the differences between the function of oddball MMN and that of control MMN are discussed.Methods Ten subjects (six men and four women) with normal hearing participated in the study.A sequence was presented to these subjects through a loudspeaker,the sequence included four blocks,a control block and three oddball blocks.The control block was made up of five components (one pure tone and four Chinese tones) with equiprobability.The oddball blocks were made up of two components,one was a standard stimulus (tone 1) and the other was a deviant stimulus (tone 2 or tone 3 or tone 4).Electroencephalogram (EEG) data were recorded when the sequence was presented and MMNs were obtained from the analysis of the EEG data.Results Two kinds of MMNs were obtained,oddball MMN and control MMN.Oddball MMN was obtained by subtracting the ERP elicited by standard stimulation (tone 1) from that elicited by deviant stimulation (tone 2 or tone 3 or tone 4) in the oddball block; control MMN was obtained by subtracting the ERP elicited by the tone in control block,which was the same tone as the deviant stimulation in the oddball block,from the ERP elicited by deviant stimulation (tone 2 or tone 3 or tone 4)in the oddball block.There were two negative waves in oddball MMN,one appeared around 150 ms (oddball MMN 1),the other around 300 ms (oddball MMN 2).Only one negative wave appeared around 300 ms in control MMN,which was corresponding to the oddball MMN 2.We performed the statistical analyses in each paradigm for latencies and amplitudes for oddball MMN 2 in discriminating the three Chinese tones and reported no significant differences.But the latencies and amplitudes

  14. Measurement of intraindividual airway tone heterogeneity and its importance in asthma


    Brown, Robert H.; Togias, Alkis


    While airways have some degree of baseline tone, the level and variability of this tone is not known. It is also unclear whether there is a difference in airway tone or in the variability of airway tone between asthmatic and healthy individuals. This study examined airway tone and intraindividual airway tone heterogeneity (variance of airway tone) in vivo in 19 individuals with asthma compared with 9 healthy adults. All participants underwent spirometry, body plethysmography, and high-resolut...

  15. Tune in to the Tone: Lexical Tone Identification is Associated with Vocabulary and Word Recognition Abilities in Young Chinese Children. (United States)

    Tong, Xiuli; Tong, Xiuhong; McBride-Chang, Catherine


    Lexical tone is one of the most prominent features in the phonological representation of words in Chinese. However, little, if any, research to date has directly evaluated how young Chinese children's lexical tone identification skills contribute to vocabulary acquisition and character recognition. The present study distinguished lexical tones from segmental phonological awareness and morphological awareness in order to estimate the unique contribution of lexical tone in early vocabulary acquisition and character recognition. A sample of 199 Cantonese children aged 5-6 years was assessed on measures of lexical tone identification, segmental phonological awareness, morphological awareness, nonverbal ability, vocabulary knowledge, and Chinese character recognition. It was found that lexical tone awareness and morphological awareness were both associated with vocabulary knowledge and character recognition. However, there was a significant relationship between lexical tone awareness and both vocabulary knowledge and character recognition, even after controlling for the effects of age, nonverbal ability, segmental phonological awareness and morphological awareness. These findings suggest that lexical tone is a key factor accounting for individual variance in young children's lexical acquisition in Chinese, and that lexical tone should be considered in understanding how children learn new Chinese vocabulary words, in either oral or written forms.

  16. Classical conditioned responses to absent tones

    Directory of Open Access Journals (Sweden)

    Häusler Udo


    Full Text Available Abstract Background Recent evidence for a tight coupling of sensorimotor processes in trained musicians led to the question of whether this coupling extends to preattentively mediated reflexes; particularly, whether a classically conditioned response in one of the domains (auditory is generalized to another (tactile/motor on the basis of a prior association in a second-order Pavlovian paradigm. An eyeblink conditioning procedure was performed in 17 pianists, serving as a model for overlearned audiomotor integration, and 14 non-musicians. Results: During the training session, subjects were conditioned to respond to auditory stimuli (piano tones. During a subsequent testing session, when subjects performed keystrokes on a silent piano, pianists showed significantly higher blink rates than non-musicians. Conclusion These findings suggest a tight coupling of the auditory and motor domains in musicians, pointing towards training-dependent mechanisms of strong cross-modal sensorimotor associations even on sub-cognitive processing levels.

  17. Disorders of pitch production in tone deafness. (United States)

    Bella, Simone Dalla; Berkowska, Magdalena; Sowiński, Jakub


    Singing is as natural as speaking for the majority of people. Yet some individuals (i.e., 10-15%) are poor singers, typically performing or imitating pitches and melodies inaccurately. This condition, commonly referred to as "tone deafness," has been observed both in the presence and absence of deficient pitch perception. In this article we review the existing literature concerning normal singing, poor-pitch singing, and, briefly, the sources of this condition. Considering that pitch plays a prominent role in the structure of both music and speech we also focus on the possibility that speech production (or imitation) is similarly impaired in poor-pitch singers. Preliminary evidence from our laboratory suggests that pitch imitation may be selectively inaccurate in the music domain without being affected in speech. This finding points to separability of mechanisms subserving pitch production in music and language.

  18. Bidirectional Regulatory Effects of Dexmedetomidine on Porcine Coronary Tone In Vitro (United States)

    Zhou, Shu-Zhi; Li, Zhi-Ming; Liu, Xue-Ru; Zhou, Jun; Tan, Xiao-Qiu; Yang, Yan; Wei, Ji-Cheng


    Background Studies in vivo have shown that dexmedetomidine (DEX) could protect the myocardium and modulate the coronary blood flow. This study aimed to investigate the direct and concentration-dependent effects of DEX on the tone of porcine coronary artery in vitro and the underlying mechanisms. Material/Methods Distal branches of the porcine anterior descending coronary arteries were dissected and cut into 3–5 mm rings. The tones of coronary rings in response to cumulative DEX were measured using the PowerLab system. Coronary rings were divided into three groups: 1) endothelium-intact coronary rings without drug pretreatment (control); 2) endothelium-intact coronary rings pretreated with either yohimbine, tetraethylamine (TEA) or NG-nitro-L-arginine methyl ester (L-NAME); and 3) endothelium-denuded coronary rings pretreated with either yohimbine or TEA. Results DEX induced coronary ring relaxation at lower concentrations (10−9 to 10−7 M) followed by constriction at higher concentrations (10−6 to 10−5 M). The coronary constrictive effect of higher DEX (10−5 M) was greater in the endothelium-denuded rings than in the endothelium-intact rings. Yohimbine reduced the coronary constrictive effect of DEX at higher concentrations (10−6 to 10−5 M). TEA and L-NAME significantly reduced the coronary relaxing effect of DEX at lower concentrations (10−9 to 10−7 M) in endothelium-intact rings. TEA attenuated the coronary relaxation induced by DEX in endothelium-denuded rings. Conclusions DEX exerts bidirectional effects on porcine coronary tone. The coronary relaxing effect of DEX at lower concentrations is likely associated with endothelium integrity, NO synthesis and BKCa channel activation, while the coronary constrictive effect of DEX at higher concentrations is mediated by α2 adrenoceptors in the coronary smooth muscle cells. PMID:28369032

  19. One-tone suppression in the frog auditory nerve

    DEFF Research Database (Denmark)

    Christensen-Dalsgaard, J; Jørgensen, M B


    frequencies ranged from 700 to 1200 Hz. Spontaneous activities for the fibers showing one-tone suppression ranged from 3 to 75 spikes/s. Spontaneous activities above 40 spikes/s and the phenomenon of one-tone suppression itself has not been reported previously for frogs. The population of fibers showing one...

  20. Analysis on the relations between piano touch and tone


    Nie, Lai-Mei


    In piano playing, different ways of touch lead to different tones. The effects of changing forces on keys are presented by changing interaction between hammer and string. The thesis focuses on several important variables in hammer-string system and draws conclusions to the question about piano touch and tone.

  1. Tone sandhi, prosodic phrasing, and focus marking in Wenzhou Chinese

    NARCIS (Netherlands)

    Scholz, Franziska


    In most languages, focus (i.e. highlighting information) is marked by modifying the melody of the sentence. But how is focus marked in a Chinese dialect with eight different citation tones and a complex tonal phonology? This thesis investigates the connection between tonal realization and tone chang

  2. Dissimilation in the Second Language Acquisition of Mandarin Chinese Tones (United States)

    Zhang, Hang


    This article extends Optimality Theoretic studies to the research on second language tone phonology. Specifically, this work analyses the acquisition of identical tone sequences in Mandarin Chinese by adult speakers of three non-tonal languages: English, Japanese and Korean. This study finds that the learners prefer not to use identical lexical…

  3. Pilot tones in WDM networks with wavelength converters

    DEFF Research Database (Denmark)

    Kloch, Allan; Mikkelsen, Benny; Stubkjær, Kristian


    Here we investigate the transmission of a pilot tone through an interferometric wavelength converter (IWC) in conjunction with a 2.5 Gbit/s experiment. The pilot tone is added by sinusoidal modulation of the bias current to the signal laser. After the IWC (Michelson interferometer) the converted...

  4. Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteries

    DEFF Research Database (Denmark)

    Ploug, Kenneth Beri; Edvinsson, Lars; Olesen, Jes;


    ATP-sensitive potassium (K(ATP)) channels play an important role in the regulation of cerebral vascular tone. In vitro studies using synthetic K(ATP) channel openers suggest that the pharmacological profiles differ between rat basilar arteries and rat middle cerebral arteries. To address this issue...

  5. Factors Influencing Sensitivity to Lexical Tone in an Artificial Language: Implications for Second Language Learning (United States)

    Caldwell-Harris, Catherine L.; Lancaster, Alia; Ladd, D. Robert; Dediu, Dan; Christiansen, Morten H.


    This study examined whether musical training, ethnicity, and experience with a natural tone language influenced sensitivity to tone while listening to an artificial tone language. The language was designed with three tones, modeled after level-tone African languages. Participants listened to a 15-min random concatenation of six 3-syllable words.…

  6. Brainstem cholinergic modulation of muscle tone in infant rats. (United States)

    Gall, Andrew J; Poremba, Amy; Blumberg, Mark S


    In week-old rats, lesions of the dorsolateral pontine tegmentum (DLPT) and nucleus pontis oralis (PnO) have opposing effects on nuchal muscle tone. Specifically, pups with DLPT lesions exhibit prolonged bouts of nuchal muscle atonia (indicative of sleep) and pups with PnO lesions exhibit prolonged bouts of high nuchal muscle tone (indicative of wakefulness). Here we test the hypothesis that nuchal muscle tone is modulated, at least in part, by cholinergically mediated interactions between these two regions. First, in unanesthetized pups, we found that chemical infusion of the cholinergic agonist carbachol (22 mm, 0.1 microL) within the DLPT produced high muscle tone. Next, chemical lesions of the PnO were used to produce a chronic state of high nuchal muscle tone, at which time the cholinergic antagonist scopolamine (10 mm, 0.1 microL) was infused into the DLPT. Scopolamine effectively decreased nuchal muscle tone, thus suggesting that lesions of the PnO increase muscle tone via cholinergic activation of the DLPT. Using 2-deoxyglucose autoradiography, metabolic activation throughout the DLPT was observed after PnO lesions. Finally, consistent with the hypothesis that PnO inactivation produces high muscle tone, infusion of the sodium channel blocker lidocaine (2%) into the PnO of unanesthetized pups produced rapid increases in muscle tone. We conclude that, even early in infancy, the DLPT is critically involved in the regulation of muscle tone and behavioral state, and that its activity is modulated by a cholinergic mechanism that is directly or indirectly controlled by the PnO.

  7. Determinants of an elevated pulmonary arterial pressure in patients with pulmonary arterial hypertension. (United States)

    Sakao, Seiichiro; Voelkel, Norbert F; Tanabe, Nobuhiro; Tatsumi, Koichiro


    Given the difficulty of diagnosing early-stage pulmonary arterial hypertension (PAH) due to the lack of signs and symptoms, and the risk of an open lung biopsy, the precise pathological features of presymptomatic stage lung tissue remain unknown. It has been suggested that the maximum elevation of the mean pulmonary arterial pressure (P pa) is achieved during the early symptomatic stage, indicating that the elevation of the mean P pa is primarily driven by the pulmonary vascular tone and/or some degree of pulmonary vascular remodeling completed during this stage. Recently, the examination of a rat model of severe PAH suggested that the severe PAH may be primarily determined by the presence of intimal lesions and/or the vascular tone in the early stage. Human data seem to indicate that intimal lesions are essential for the severely increased pulmonary arterial blood pressure in the late stage of the disease.However, many questions remain. For instance, how does the pulmonary hemodynamics change during the course of the disease, and what drives the development of severe PAH? Although it is generally acknowledged that both pulmonary vascular remodeling and the vascular tone are important determinants of an elevated pulmonary arterial pressure, which is the root cause of the time-dependent progression of the disease? Here we review the recent histopathological concepts of PAH with respect to the progression of the lung vascular disease.

  8. Raynaud's phenomenon in arterial obstructive disease of the hand demonstrated by locally provoked cooling

    DEFF Research Database (Denmark)

    Nielsen, Steen Levin; Nobin, B A; Hirai, M;


    Finger systolic blood pressure (FSP) was measured by cuff technique before and after local cooling in three groups of patients (Raynaud's disease (7), subclavian stenoses, (5), thrombo-angiitis obliterans (15)), and in 15 normals. The response to finger cooling registered as a decrease in FSP...... indicates an increase of digital arterial tone. In all three groups, digital arterial tone increased more than in normals during finger cooling. Patients with Raynaud's disease showed a pathological increase in arterial tone at 23.5 degrees C with closure of the digital arteries at a mean temperature of 18.......5 degrees C. The temperature eliciting these phenomena in patients with thrombo-angiitis obliterans was about 7 degrees C lower (16.5 and 11.0 degrees C, respectively). Accordingly, cold sensitivity and Raynaud's phenomena in the two groups may have a different pathophysiological mechanism, namely...

  9. Agmatine suppresses peripheral sympathetic tone by inhibiting N-type Ca(2+) channel activity via imidazoline I2 receptor activation. (United States)

    Kim, Young-Hwan; Jeong, Ji-Hyun; Ahn, Duck-Sun; Chung, Seungsoo


    Agmatine, a putative endogenous ligand of imidazoline receptors, suppresses cardiovascular function by inhibiting peripheral sympathetic tone. However, the molecular identity of imidazoline receptor subtypes and its cellular mechanism underlying the agmatine-induced sympathetic suppression remains unknown. Meanwhile, N-type Ca(2+) channels are important for the regulation of NA release in the peripheral sympathetic nervous system. Therefore, it is possible that agmatine suppresses NA release in peripheral sympathetic nerve terminals by inhibiting Ca(2+) influx through N-type Ca(2+) channels. We tested this hypothesis by investigating agmatine effect on electrical field stimulation (EFS)-evoked contraction and NA release in endothelium-denuded rat superior mesenteric arterial strips. We also investigated the effect of agmatine on the N-type Ca(2+) current in superior cervical ganglion (SCG) neurons in rats. Our study demonstrates that agmatine suppresses peripheral sympathetic outflow via the imidazoline I2 receptor in rat mesenteric arteries. In addition, the agmatine-induced suppression of peripheral vascular sympathetic tone is mediated by modulating voltage-dependent N-type Ca(2+) channels in sympathetic nerve terminals. These results suggest a potential cellular mechanism for the agmatine-induced suppression of peripheral sympathetic tone. Furthermore, they provide basic and theoretical information regarding the development of new agents to treat hypertension.

  10. Acute arterial occlusion - kidney (United States)

    Acute renal arterial thrombosis; Renal artery embolism; Acute renal artery occlusion; Embolism - renal artery ... kidney can often result in permanent kidney failure. Acute arterial occlusion of the renal artery can occur after injury or trauma to ...

  11. Shear Stress, Reactive Oxygen Species, and Arterial Structure and Function

    NARCIS (Netherlands)

    H.L. Matlung; E.N. Bakker; E. VanBavel


    Shear stress is well known to be a key factor in the regulation of small-artery tone and structure. Although nitric oxide is a major endothelium-derived factor involved in short-and long-term regulation of vascular caliber, it is clear that other mechanisms also can be involved. This review discusse

  12. Attention deficits revealed by passive auditory change detection for pure tones and lexical tones in ADHD children

    Directory of Open Access Journals (Sweden)

    Ming-Tao eYang


    Full Text Available Inattention has been a major problem in children with attention deficit/hyperactivity disorder (ADHD, accounting for their behavioral and cognitive dysfunctions. However, there are at least three processing steps underlying attentional control for auditory change detection, namely pre-attentive change detection, involuntary attention orienting, and attention reorienting for further evaluation. This study aimed to examine whether children with ADHD would show deficits in any of these subcomponents by using mismatch negativity (MMN, P3a, and late discriminative negativity (LDN as event-related potential (ERP markers, under the passive auditory oddball paradigm. Two types of stimuli - pure tones and Mandarin lexical tones - were used to examine if the deficits were general across linguistic and non-linguistic domains. Participants included 15 native Mandarin-speaking children with ADHD and 16 age-matched controls (across groups, age ranged between 6 and 15 years. Two passive auditory oddball paradigms (lexical tones and pure tones were applied. Pure tone paradigm included standard stimuli (1000 Hz, 80% and two deviant stimuli (1015 Hz and 1090 Hz, 10% each. The Mandarin lexical tone paradigm’s standard stimuli was /yi3/ (80% and two deviant stimuli were /yi1/ and /yi2/ (10% each. The results showed no MMN difference, but did show attenuated P3a and enhanced LDN to the large deviants for both pure and lexical tone changes in the ADHD group. Correlation analysis showed that children with higher ADHD tendency, as indexed by parents’ and teachers’ rating on ADHD symptoms, showed less positive P3a amplitudes when responding to large lexical tone deviants. Thus, children with ADHD showed impaired auditory change detection for both pure tones and lexical tones in both involuntary attention switching, and attention reorienting for further evaluation. These ERP markers may therefore be used for evaluation of anti-ADHD drugs that aim to alleviate these

  13. The Neural Substrates Underlying the Implementation of Phonological Rule in Lexical Tone Production: An fMRI Study of the Tone 3 Sandhi Phenomenon in Mandarin Chinese. (United States)

    Chang, Claire H C; Kuo, Wen-Jui


    This study examined the neural substrates underlying the implementation of phonological rule in lexical tone by the Tone 3 sandhi phenomenon in Mandarin Chinese. Tone 3 sandhi is traditionally described as the substitution of Tone 3 with Tone 2 when followed by another Tone 3 (33 →23) during speech production. Tone 3 sandhi enables the examination of tone processing in the phonological level with the least involvement of segments. Using the fMRI technique, we measured brain activations corresponding to the monosyllable and disyllable sequences of the four Chinese lexical tones, while manipulating the requirement on overt oral response. The application of Tone 3 sandhi to disyllable sequence of Tone 3 was confirmed by our behavioral results. Larger brain responses to overtly produced disyllable Tone 3 (33 > 11, 22, and 44) were found in right posterior IFG by both whole-brain and ROI analyses. We suggest that the right IFG was responsible for the processing of Tone 3 sandhi. Intense temporo-frontal interaction is needed in speech production for self-monitoring. The involvement of the right IFG in tone production might result from its interaction with the right auditory cortex, which is known to specialize in pitch. Future studies using tools with better temporal resolutions are needed to illuminate the dynamic interaction between the right inferior frontal regions and the left-lateralized language network in tone languages.

  14. Frequency ratios and the perception of tone patterns. (United States)

    Schellenberg, E G; Trehub, S E


    We quantified the relative simplicity of frequency ratios and reanalyzed data from several studies on the perception of simultaneous and sequential tones. Simplicity of frequency ratios accounted for judgments of consonance and dissonance and for judgments of similarity across a wide range of tasks and listeners. It also accounted for the relative ease of discriminating tone patterns by musically experienced and inexperienced listeners. These findings confirm the generality of previous suggestions of perceptual processing advantages for pairs of tones related by simple frequency ratios.

  15. A linear programming approach for optimal contrast-tone mapping. (United States)

    Wu, Xiaolin


    This paper proposes a novel algorithmic approach of image enhancement via optimal contrast-tone mapping. In a fundamental departure from the current practice of histogram equalization for contrast enhancement, the proposed approach maximizes expected contrast gain subject to an upper limit on tone distortion and optionally to other constraints that suppress artifacts. The underlying contrast-tone optimization problem can be solved efficiently by linear programming. This new constrained optimization approach for image enhancement is general, and the user can add and fine tune the constraints to achieve desired visual effects. Experimental results demonstrate clearly superior performance of the new approach over histogram equalization and its variants.

  16. School burnout: increased sympathetic vasomotor tone and attenuated ambulatory diurnal blood pressure variability in young adult women. (United States)

    May, Ross W; Sanchez-Gonzalez, Marcos A; Fincham, Frank D


    Two studies examined autonomic and cardiovascular functioning that may link school burnout to cardiovascular risk factors in young healthy adult females. Study 1 (N = 136) investigated whether school burnout was related to resting values of blood pressure (BP) and blood pressure variability (BPV) through laboratory beat-to-beat BP assessment. Study 2 (N = 94) examined the link between school burnout and diurnal BPV through ambulatory BP monitoring. Controlling for anxiety and depressive symptomatology, school burnout demonstrated strong positive relationships with indices of cardiac sympathovagal tone, sympathetic vasomotor tone, inefficient myocardial oxygen consumption, increased 24-h ambulatory heart rate and BP, blunted BP diurnal variability, and increased arterial stiffness. These studies establish cardiovascular biomarkers of school burnout and suggest that even in a seemingly healthy sample school burnout may predispose females to increased cardiovascular risk. Several future lines of research are outlined.

  17. Two-tone masking in normal hearing listeners. (United States)

    Rabinowitz, W M; Bilger, R C; Trahiotis, C; Nuetzel, J


    Psychophysical measurements of two-tone masking [E. Zwicker, Acustica 4, 415-420 (1954)] were made at 0.25, 0.5, 1, 2, and 4 kHz utilizing a masker level of 62 dB SPL/tone. Fifty-eight "untrained" subjects were tested using a single run of a 4IFC adaptive procedure for each condition. Individual data were highly variable. Average data were systematic; they were analyzed using a two-line-regression procedure and the obtained critical-bandwidth estimates approximated normative values. Analysis of the literature revealed that a substantial increase of estimated critical bandwidth versus masker level occurs in two-tone masking. A portion of this increase appears artificial and stems from the relative effectiveness of the higher frequency masker tone at high masker levels. An alternative masker-frequency spacing is suggested to reduce level effects. Implications for an underlying critical-band mechanism are discussed.

  18. Global Database of Events, Language, and Tone (GDELT Project) (United States)

    World Wide Human Geography Data Working Group — The Global Database of Events, Language, and Tone (GDELT Project) monitors the world's broadcast, print, and web news from nearly every corner of every country in...

  19. Visual emotional context modulates brain potentials elicited by unattended tones


    Sugimoto, Sayaka; Nittono, Hiroshi; Hori, Tadao


    To examine whether brain electrical responses to environmental stimuli were influenced by emotional contexts, event-related potentials (ERPs) elicited by nonstartle probe tones were recorded from 13 student volunteers while they were viewing emotionally positive, neutral, and negative slides of the International Affective Picture System. The auditory stimuli consisted of high-deviant (2000 Hz, p=.08), low-deviant (1050 Hz, p=.08), and standard (1000 Hz, p=.84) tones with a mean onset-to-onset...

  20. Increased dynamic regulation of postural tone through Alexander Technique training


    Cacciatore, TW; Gurfinkel, VS; Horak, FB; Cordo, PJ; Ames, KE


    Gurfinkel and colleagues (2006) recently found that healthy adults dynamically modulate postural muscle tone in the body axis during anti-gravity postural maintenance and that this modulation is inversely correlated with axial stiffness. Our objective in the present study was to investigate whether dynamic modulation of axial postural tone can change through training. We examined whether teachers of the Alexander Technique (AT), who undergo “long-term” (3-year) training, have greater modulati...

  1. Pilot tone modulation used for channel identification in OTDM networks

    DEFF Research Database (Denmark)

    Clausen, Anders; Bennike, Jon; Oxenløwe, Leif Katsuo


    The principle of applying a pilot tone to an OTDM signal, in order to identify a specific channel, is presented. The impact on BER system performance is characterised as function of modulation index.......The principle of applying a pilot tone to an OTDM signal, in order to identify a specific channel, is presented. The impact on BER system performance is characterised as function of modulation index....

  2. Tone-3 Accent Realization in Short Chinese Sentences

    Institute of Scientific and Technical Information of China (English)

    CAO Wen; ZHANG Jinsong


    To investigate how a low tone (tone-3,T3) syllable in Chinese can be perceived to be focal ac-canted or not,a total of 156 sentences containing tone-3 words were synthesized and used as stimuli in a perceptual study.The sentences differed in the falling value between the two high pitches,and in the dura-tion and phonation types of the T3 syllables.Thirty-nine subjects were asked to judge where the focus or accent was for each sentence.The results show that at least three degrees of pitch drop are involved in the focus recognition: a big sized drop of about 10 semitones; a middle sized drop of about 6 semitones; a small sized drop of about 2 semitones.The results suggest that the three sizes of pitch drop have different indica-tions in Chinese intonation,depending on both the tone and the tone combination.In perception,there are various ways to realize tone-3 focus in the Tx-T3-Ty sentences series,but in production or for text-to-speech synthesis,the rule simply is making a middle sized pitch drop with a long and creaky T3 syllable.Similarly,to focus on the low tone syllable in the T3-Tx-Ty sentences,a creaky T3 syllable is essential.However,a long T3 syllable is a strong determinant for a low tone focus in the Tx-Ty-T3 sentences.

  3. Method to Measure Tone of Axial and Proximal Muscle



    The control of tonic muscular activity remains poorly understood. While abnormal tone is commonly assessed clinically by measuring the passive resistance of relaxed limbs1, no systems are available to study tonic muscle control in a natural, active state of antigravity support. We have developed a device (Twister) to study tonic regulation of axial and proximal muscles during active postural maintenance (i.e. postural tone). Twister rotates axial body regions relative to each other about the ...

  4. Effect of harmonic rank on the streaming of complex tones

    DEFF Research Database (Denmark)

    Madsen, Sara Miay Kim; Dau, Torsten; Moore, Brian C.J.


    The effect of the rank of the harmonics on sequential stream segregation of complex tones was investigated for normal-hearing participants with no musical training. It was hypothesized that stream segregation would be greater for tones with high pitch salience, as assessed by fundamental frequency....... There was a significant trend for less stream segregation with increasing harmonic rank. The amount of stream segregation was inversely correlated with the f0 difference limens, consistent with the hypothesis....

  5. The role of DPO-1 and XE991-sensitive potassium channels in perivascular adipose tissue-mediated regulation of vascular tone

    Directory of Open Access Journals (Sweden)

    Dmitry Tsvetkov


    Full Text Available The anti-contractile effect of perivascular adipose tissue (PVAT is an important mechanism in the modulation of vascular tone in peripheral arteries. Recent evidence has implicated the XE991-sensitive voltage-gated Kv (KCNQ channels in the regulation of arterial tone by PVAT. However, until now the in vivo pharmacology of the involved vascular Kv channels with regard to XE991 remains undetermined, since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl phosphine oxide-1 (DPO-1. In this study, we tested whether Kv1.5 channels are involved in the control of mesenteric arterial tone and its regulation by PVAT. Our study was also aimed at extending our current knowledge on the in situ vascular pharmacology of DPO-1 and XE991 regarding Kv1.5 and BKCa channels, in helping to identify the nature of K+ channels that could contribute to PVAT-mediated relaxation. XE991 at 30 µM reduced the anti-contractile response of PVAT, but had no effects on vasocontraction induced by phenylephrine (PE in the absence of PVAT. Similar effects were observed for XE991 at 0.3 µM, which is known to almost completely inhibit mesenteric artery VSMC Kv currents. 30 µM XE991 did not affect BKCa currents in VSMCs. Kcna5-/- arteries and wild-type arteries incubated with 1 µM DPO-1 showed normal vasocontractions in response to PE in the presence and absence of PVAT. Kv current density and inhibition by 30 µM XE991 were normal in mesenteric artery VSMCs isolated from Kcna5-/- mice. We conclude that Kv channels are involved in the control of arterial vascular tone by PVAT. These channels are present in VSMCs and very potently inhibited by the KCNQ channel blocker XE991. BKCa channels and/or DPO-1 sensitive Kv1.5 channels in VSMCs are not the downstream mediators of the XE991 effects on PVAT-dependent arterial vasorelaxation. Further studies will need to be undertaken to examine the role of other Kv channels in

  6. Visual emotional context modulates brain potentials elicited by unattended tones. (United States)

    Sugimoto, Sayaka; Nittono, Hiroshi; Hori, Tadao


    To examine whether brain electrical responses to environmental stimuli were influenced by emotional contexts, event-related potentials (ERPs) elicited by nonstartle probe tones were recorded from 13 student volunteers while they were viewing emotionally positive, neutral, and negative slides of the International Affective Picture System. The auditory stimuli consisted of high-deviant (2000 Hz, p=.08), low-deviant (1050 Hz, p=.08), and standard (1000 Hz, p=.84) tones with a mean onset-to-onset interval of 600 ms. Participants were told to ignore the tones. High-deviant tones elicited a larger N1 (peaking around 100 ms) when participants were viewing negative slides than when viewing positive slides. The amplitude of the P2 elicited by standard tones (peaking around 170 ms) was smaller when participants were viewing positive slides than when viewing negative and neutral slides. The amplitude of the mismatch negativity (150-200 ms) tended to reduce during positive slide presentation, but this difference appeared to be due to reduction of the P2 elicited by standard tones. These findings suggest that visually induced emotional states have a sequential effect on auditory information processing, in that the influence of negative emotion appears at an earlier stage than that of positive emotion.

  7. Production and Perception of Tone 3 Focus in Mandarin Chinese. (United States)

    Lee, Yong-Cheol; Wang, Ting; Liberman, Mark


    This study uses production and perception experiments to explore tone 3 focus in Mandarin Chinese. Overall, contrastive focus in Mandarin is clearly marked with increased duration, intensity, and pitch range: in the experiments, listeners identified focused syllables correctly more than 90% of the time. However, a tone 3 syllable offers a smaller capacity for pitch range expansion under focus, and also yields less intensity increase; in addition, local dissimilation increases the duration, intensity, and pitch range of adjacent syllables within the same phrase as a focused tone 3 syllable. As a result, tone 3 focus was less well identified by listeners (77.1%). We suggest that the relatively poor identification of tone 3 focus is due to the smaller capacity for pitch range expansion, the confusion from within-phrase local dissimilatory effects, and the relatively weak intensity of tone 3. This study demonstrates that even within a language where purely prosodic marking of focus is clear, the location of prosodic focus can be difficult to identify in certain circumstances. Our results underline the conclusion, established in other work, that prosodic marking of focus is not universal, but is expressed through the prosodic system of each language.

  8. Method to measure tone of axial and proximal muscle. (United States)

    Gurfinkel, Victor S; Cacciatore, Timothy W; Cordo, Paul J; Horak, Fay B


    The control of tonic muscular activity remains poorly understood. While abnormal tone is commonly assessed clinically by measuring the passive resistance of relaxed limbs, no systems are available to study tonic muscle control in a natural, active state of antigravity support. We have developed a device (Twister) to study tonic regulation of axial and proximal muscles during active postural maintenance (i.e. postural tone). Twister rotates axial body regions relative to each other about the vertical axis during stance, so as to twist the neck, trunk or hip regions. This twisting imposes length changes on axial muscles without changing the body's relationship to gravity. Because Twister does not provide postural support, tone must be regulated to counteract gravitational torques. We quantify this tonic regulation by the restive torque to twisting, which reflects the state of all muscles undergoing length changes, as well as by electromyography of relevant muscles. Because tone is characterized by long-lasting low-level muscle activity, tonic control is studied with slow movements that produce "tonic" changes in muscle length, without evoking fast "phasic" responses. Twister can be reconfigured to study various aspects of muscle tone, such as co-contraction, tonic modulation to postural changes, tonic interactions across body segments, as well as perceptual thresholds to slow axial rotation. Twister can also be used to provide a quantitative measurement of the effects of disease on axial and proximal postural tone and assess the efficacy of intervention.

  9. [Regulation of vasomotor tone of small skeletal muscle veins by intrinsic mechanisms]. (United States)

    Szénási, Annamária; Dörnyei, Gabriella; Rácz, Anita; Debreczeni, Béla; Koller, Ákos


    In many developed countries the prevalence of venous disorders and its consequences are higher than that of arterial diseases. Thus it is very important to understand the exact physiological and pathophysiological function of small veins and their control mechanisms. Small veins and venules have an important role in the regulation of capillary fluid exchange, as well as return of the venous blood into the heart. However, there is only limited knowledge available regarding the role of local mechanisms controlling the vasomotor tone and diameter of small veins. In the last decade the authors focused on the elucidation of these mechanisms in isolated skeletal muscle venules of rats. Their results suggest that the tone of small veins is controlled by the integration of several mechanisms, activated by the intraluminal pressure and flow/wall shear stress, in addition to numerous local mediators synthesized and released from the smooth muscle and endothelium. These mechanisms are involved - in a complex manner - in the control of postcapillary resistance, thus regulation of tissue blood supply, venous return and consequently in the modulation of the cardiac output, as well.

  10. Arterial Stiffness and Dialysis Calcium Concentration

    Directory of Open Access Journals (Sweden)

    Fabrice Mac-Way


    Full Text Available Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workload and decreased myocardial perfusion. Although the clinical consequence of aortic stiffness has been clearly established, its pathophysiology in various clinical conditions still remains poorly understood. The aim of the present paper is to review the studies that have looked at the impact of dialysis calcium concentration on arterial stiffness. Overall, the results of small short-term studies suggest that higher dialysis calcium is associated with a transient but significant increase in arterial stiffness. This calcium dependant increase in arterial stiffness is potentially explained by increased vascular smooth muscle tone of the conduit arteries and is not solely explained by changes in mean blood pressure. However, the optimal DCa remains to be determined, and long term studies are required to evaluate its impact on the progression of arterial stiffness.

  11. Effet Hall et Magnetisme des Alliages Amorphes Nickel-Zirconium Fabriques Par Pulverisation (United States)

    Morel, Robert

    Cette these se situe dans le cadre d'une etude des proprietes electroniques et structurales des alliages metalliques amorphes, en cours depuis quelques annees a l'Universite de Montreal. Ce programme nous a entre autres amene a caracteriser la magnetoresistivite et l'effet Hall d'alliages FeZr, CoZr et NiZr, ce qui a permis de mettre en evidence deux caracteristiques de l'effet Hall: Dans les alliages amorphes ferromagnetiques, la resistivite elevee engendre un effet Hall extraordinaire beaucoup plus important que celui enregistre dans les metaux cristallins. La polarisation des spins entrai ne une asymetrie de la diffusion qui, tant dans les phases cristalline et amorphe, est tenue responsable de cette contribution. L'autre particularite du comportement de Hall de ces systemes est le renversement de signe du coefficient de Hall ordinaire, qui passe du negatif au positif dans les echantillons plus riches en zirconium. Dans les metaux cristallins, un modele d'electrons libres predit un signe negatif a moins que la conduction ne soit dominee par les trous. Or, dans un milieu desordonne les memes concepts sont difficilement applicables et de nouvelles theories ont du etre elaborees pour expliquer ce phenomene. Jusqu'a maintenant, l'etude des alliages amorphes nickel-zirconium s'est faite surtout a partir d'echantillons fabriques par trempe sur roue. Malheureusement cette technique ne permet pas la fabrication d'alliages contenant plus de 70% de nickel, a l'exception du seul compose Ni _{90}Zr_{10 }. Pour pallier a cette lacune et etendre nos connaissance a l'ensemble de la gamme de compositions, nous avons fabrique par pulverisation cathodique des echantillons NiZr amorphes--et quelques alliages cristallins tres riches en nickel--couvrant une bonne partie de la gamme interdite par la technique de trempe sur roue. Dans un premier temps, par comparaison avec les resultats connus nous avons mis en evidence les similitudes et les differences entre les alliages obtenus par

  12. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. (United States)

    Schepelmann, M; Yarova, P L; Lopez-Fernandez, I; Davies, T S; Brennan, S C; Edwards, P J; Aggarwal, A; Graça, J; Rietdorf, K; Matchkov, V; Fenton, R A; Chang, W; Krssak, M; Stewart, A; Broadley, K J; Ward, D T; Price, S A; Edwards, D H; Kemp, P J; Riccardi, D


    The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the hypothesis that the CaSR expressed in vascular smooth muscle cells (VSMC) is directly involved in regulation of blood pressure and blood vessel tone. Mice with targeted CaSR gene ablation from vascular smooth muscle cells (VSMC) were generated by breeding exon 7 LoxP-CaSR mice with animals in which Cre recombinase is driven by a SM22α promoter (SM22α-Cre). Wire myography performed on Cre-negative [wild-type (WT)] and Cre-positive (SM22α)CaSR(Δflox/Δflox) [knockout (KO)] mice showed an endothelium-independent reduction in aorta and mesenteric artery contractility of KO compared with WT mice in response to KCl and to phenylephrine. Increasing extracellular calcium ion (Ca(2+)) concentrations (1-5 mM) evoked contraction in WT but only relaxation in KO aortas. Accordingly, diastolic and mean arterial blood pressures of KO animals were significantly reduced compared with WT, as measured by both tail cuff and radiotelemetry. This hypotension was mostly pronounced during the animals' active phase and was not rescued by either nitric oxide-synthase inhibition with nitro-l-arginine methyl ester or by a high-salt-supplemented diet. KO animals also exhibited cardiac remodeling, bradycardia, and reduced spontaneous activity in isolated hearts and cardiomyocyte-like cells. Our findings demonstrate a role for CaSR in the cardiovascular system and suggest that physiologically relevant changes in extracellular Ca(2+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.

  13. 47 CFR 11.12 - Two-tone Attention Signal encoder and decoder. (United States)


    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Two-tone Attention Signal encoder and decoder... SYSTEM (EAS) General § 11.12 Two-tone Attention Signal encoder and decoder. Existing two-tone Attention... Attention Signal decoder will no longer be required and the two-tone Attention Signal will be used...

  14. Effets des electrons secondaires sur l'ADN (United States)

    Boudaiffa, Badia

    Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire

  15. Context, Contrast, and Tone of Voice in Auditory Sarcasm Perception. (United States)

    Voyer, Daniel; Thibodeau, Sophie-Hélène; Delong, Breanna J


    Four experiments were conducted to investigate the interplay between context and tone of voice in the perception of sarcasm. These experiments emphasized the role of contrast effects in sarcasm perception exclusively by means of auditory stimuli whereas most past research has relied on written material. In all experiments, a positive or negative computer-generated context spoken in a flat emotional tone was followed by a literally positive statement spoken in a sincere or sarcastic tone of voice. Participants indicated for each statement whether the intonation was sincere or sarcastic. In Experiment 1, a congruent context/tone of voice pairing (negative/sarcastic, positive/sincere) produced fast response times and proportions of sarcastic responses in the direction predicted by the tone of voice. Incongruent pairings produced mid-range proportions and slower response times. Experiment 2 introduced ambiguous contexts to determine whether a lower context/statements contrast would affect the proportion of sarcastic responses and response time. Results showed the expected findings for proportions (values between those obtained for congruent and incongruent pairings in the direction predicted by the tone of voice). However, response time failed to produce the predicted pattern, suggesting potential issues with the choice of stimuli. Experiments 3 and 4 extended the results of Experiments 1 and 2, respectively, to auditory stimuli based on written vignettes used in neuropsychological assessment. Results were exactly as predicted by contrast effects in both experiments. Taken together, the findings suggest that both context and tone influence how sarcasm is perceived while supporting the importance of contrast effects in sarcasm perception.

  16. Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone. (United States)

    Busija, David W; Rutkai, Ibolya; Dutta, Somhrita; Katakam, Prasad V


    Mitochondria not only produce energy in the form of ATP to support the activities of cells comprising the neurovascular unit, but mitochondrial events, such as depolarization and/or ROS release, also initiate signaling events which protect the endothelium and neurons against lethal stresses via pre-/postconditioning as well as promote changes in cerebral vascular tone. Mitochondrial depolarization in vascular smooth muscle (VSM), via pharmacological activation of the ATP-dependent potassium channels on the inner mitochondrial membrane (mitoKATP channels), leads to vasorelaxation through generation of calcium sparks by the sarcoplasmic reticulum and subsequent downstream signaling mechanisms. Increased release of ROS by mitochondria has similar effects. Relaxation of VSM can also be indirectly achieved via actions of nitric oxide (NO) and other vasoactive agents produced by endothelium, perivascular and parenchymal nerves, and astroglia following mitochondrial activation. Additionally, NO production following mitochondrial activation is involved in neuronal preconditioning. Cerebral arteries from female rats have greater mitochondrial mass and respiration and enhanced cerebral arterial dilation to mitochondrial activators. Preexisting chronic conditions such as insulin resistance and/or diabetes impair mitoKATP channel relaxation of cerebral arteries and preconditioning. Surprisingly, mitoKATP channel function after transient ischemia appears to be retained in the endothelium of large cerebral arteries despite generalized cerebral vascular dysfunction. Thus, mitochondrial mechanisms may represent the elusive signaling link between metabolic rate and blood flow as well as mediators of vascular change according to physiological status. Mitochondrial mechanisms are an important, but underutilized target for improving vascular function and decreasing brain injury in stroke patients. © 2016 American Physiological Society. Compr Physiol 6:1529-1548, 2016.

  17. The prosody of Swedish underived nouns: No lexical tones required

    Directory of Open Access Journals (Sweden)

    Bruce Morén-Duolljá


    Full Text Available This paper provides a detailed representational analysis of the morpho-prosodic system of underived nouns in a dialect of Swedish.  It shows that the morphology, stress and tonal patterns are not as complex as they first appear once the data are looked at in sufficient detail.  Further, it shows that the renowned Swedish "lexical pitch accent" is not the result of lexical tones/tonemes.  Rather, Swedish is like all other languages and uses tones to mark the edges of prosodic constituents on the surface. "Accent 2" occurs when tones mark the edge of a structural uneven trochee (i.e. recursive foot and "accent 1" occurs elsewhere. This analysis is counter all other treatments of North Germanic tones and denies the almost unquestioned assumption that there is an underlying tone specification on roots and/or affixes in many North Germanic varieties. At the same time, it unifies the intuitions behind the three previous approaches found in the literature.

  18. Mandarin Chinese Tone Recognition with an Artificial Neural Network

    Institute of Scientific and Technical Information of China (English)

    XU Li; ZHANG Wenle; ZHOU Ning; LEE Chaoyang; LI Yongxin; CHEN Xiuwu; ZHAO Xiaoyan


    Mandarin Chinese tone patterns vary in one of the four ways, i.e, (1) high level; (2) rising; (3) low falling and rising; and (4) high falling. The present study is to examine the efficacy of an artificial neural network in recognizing these tone patterns. Speech data were recorded from 12 children (3-6 years of age) and 15 adults. All subjects were native Mandarin Chinese speakers. The fundamental frequencies (FO) of each monosyllabic word of the speech data were extracted with an autocorrelation method. The pitch data(i.e., the FO contours) were the inputs to a feed-forward backpropagation artificial neural network. The number of inputs to the neural network varied from 1 to 16 and the hidden layer of the network contained neurons that varied from 1 to 16 in number. The output of the network consisted of four neurons representing the four tone patterns of Mandarin Chinese. After being trained with the Levenberg-Marquardt optimization, the neural network was able to successfully classify the tone patterns with an accuracy of about 90% correct for speech samples from both adults and children. The artificial neural network may provide an objective and effective way of assessing tone production in prelingually-deafened children who have received cochlear implants.

  19. Turbo-per-Tone Equalization for ADSL Systems

    Directory of Open Access Journals (Sweden)

    Marc Moonen


    Full Text Available We study the equalization procedure in discrete multitone (DMT-based systems, in particular, in DMT-based ADSL systems. Traditionally, equalization is performed in the time domain by means of a channel shortening filter. Shifting the equalization operations to the frequency domain, as is done in per-tone equalization, increases the achieved bitrate by 5–10%. We show that the application of the turbo principle to per-tone equalization can provide significant additional gains. In the proposed receiver structure, referred to as a “turbo-per-tone equalization” structure, equalization and decoding are performed in an iterative fashion. Equalization is done by means of a linear minimum mean squared error (MMSE equalizer, using a priori information. We give a description of an efficient implementation of such an equalizer in the per-tone structure. Simulations show that we obtain a bitrate increase of 12–16% compared to the original per-tone equalization-based receiver structure.

  20. A weak-scattering model for turbine-tone haystacking (United States)

    McAlpine, A.; Powles, C. J.; Tester, B. J.


    Noise and emissions are critical technical issues in the development of aircraft engines. This necessitates the development of accurate models to predict the noise radiated from aero-engines. Turbine tones radiated from the exhaust nozzle of a turbofan engine propagate through turbulent jet shear layers which causes scattering of sound. In the far-field, measurements of the tones may exhibit spectral broadening, where owing to scattering, the tones are no longer narrow band peaks in the spectrum. This effect is known colloquially as 'haystacking'. In this article a comprehensive analytical model to predict spectral broadening for a tone radiated through a circular jet, for an observer in the far field, is presented. This model extends previous work by the authors which considered the prediction of spectral broadening at far-field observer locations outside the cone of silence. The modelling uses high-frequency asymptotic methods and a weak-scattering assumption. A realistic shear layer velocity profile and turbulence characteristics are included in the model. The mathematical formulation which details the spectral broadening, or haystacking, of a single-frequency, single azimuthal order turbine tone is outlined. In order to validate the model, predictions are compared with experimental results, albeit only at polar angle equal to 90°. A range of source frequencies from 4 to 20kHz, and jet velocities from 20 to 60ms-1, are examined for validation purposes. The model correctly predicts how the spectral broadening is affected when the source frequency and jet velocity are varied.

  1. Measurement of intraindividual airway tone heterogeneity and its importance in asthma. (United States)

    Brown, Robert H; Togias, Alkis


    While airways have some degree of baseline tone, the level and variability of this tone is not known. It is also unclear whether there is a difference in airway tone or in the variability of airway tone between asthmatic and healthy individuals. This study examined airway tone and intraindividual airway tone heterogeneity (variance of airway tone) in vivo in 19 individuals with asthma compared with 9 healthy adults. All participants underwent spirometry, body plethysmography, and high-resolution computed tomography at baseline and after maximum bronchodilation with albuterol. Airway tone was defined as the percent difference in airway diameter after albuterol at total lung capacity compared with baseline. The amount of airway tone in each airway varied both within and between subjects. The average airway tone did not differ significantly between the two groups (P = 0.09), but the intraindividual airway tone heterogeneity did (P = 0.016). Intraindividual airway tone heterogeneity was strongly correlated with airway tone (r = 0.78, P tone heterogeneity and conventional lung function outcomes. Intraindividual airway tone heterogeneity appears to be an important characteristic of airway pathophysiology in asthma.

  2. Musical Tone Law Method for the Structural Damage Detection

    Directory of Open Access Journals (Sweden)

    Weisong Yang


    Full Text Available Damage detection tests of inclined cables, steel pipes, spherical shells, and an actual cable-stayed bridge were conducted based on the proposed musical tone law method. The results show that the musical tone law method could be used in the damage detection of isotropic material structures with simple shape, like cables, pipes, plates, and shells. Having distinct spectral lines like a comb with a certain interval distribution rule is the main characteristic of the music tone law. Damage detection baseline could be established by quantizing the fitting relationship between modal orders and the corresponding frequency values. The main advantage of this method is that it could be used in the structural damage detection without vibration information of an intact structure as a reference.

  3. Consonance perception of complex-tone dyads and chords

    DEFF Research Database (Denmark)

    Rasmussen, Marc; Santurette, Sébastien; MacDonald, Ewen


    Sensory consonance and dissonance are perceptual attributes of musical intervals conveying pleasant- ness, tension, and harmony in musical phrases. For complex-tone dyads, corresponding to two musical notes played simultaneously, consonance is known to vary with the ratio in fundamental frequency....... For dyad/chord comparisons, dyads were more consonant in the intervals around the fixed third tone. Overall, chords were not found to be more dissonant than dyads. This suggests that the hypothesis according to which consonance decreases with the amount of interaction between present harmonics, arguing...... (F0) between the two tones in the dyad. While such a relationship is well established for dyads, the subjective consonance of chords containing three or more simultaneous notes, that form the basis of most musical pieces, remains to be explored. The present study aimed at comparing consonance...

  4. Complex-tone pitch representations in the human auditory system

    DEFF Research Database (Denmark)

    Bianchi, Federica

    Understanding how the human auditory system processes the physical properties of an acoustical stimulus to give rise to a pitch percept is a fascinating aspect of hearing research. Since most natural sounds are harmonic complex tones, this work focused on the nature of pitch-relevant cues...... that are necessary for the auditory system to retrieve the pitch of complex sounds. The existence of different pitch-coding mechanisms for low-numbered (spectrally resolved) and high-numbered (unresolved) harmonics was investigated by comparing pitch-discrimination performance across different cohorts of listeners......) listeners and the effect of musical training for pitch discrimination of complex tones with resolved and unresolved harmonics. Concerning the first topic, behavioral and modeling results in listeners with sensorineural hearing loss (SNHL) indicated that temporal envelope cues of complex tones...

  5. On the origin of impinging tones at low supersonic flow

    CERN Document Server

    Wilke, Robert


    Impinging compressible jets may cause deafness and material fatigue due to immensely loud tonal noise. It is generally accepted that a feedback mechanism similar to the screech feedback loop is responsible for impinging tones. The close of the loop remained unclear. One hypothesis hold up in the literature explains the emanated sound with the direct interaction of vortices and the wall. Other explanations name the standoff shock oscillations as the origin of the tones. Using direct numerical simulations (DNS) we were able to identify the source mechanism for under-expanded impinging jets with a nozzle pressure ratio (NPR) of 2.15 and a plate distance of 5 diameters. We found two different types of interactions between vortices and shocks to be responsible for the generation of the impinging tones. They are not related to screech.

  6. Phonology in the Lexical Processing of Chinese: Priming Tone Neighbors

    Institute of Scientific and Technical Information of China (English)

    Zhou Xiaolin


    Using both visual-visual and auditory-visual priming lexical decision tasks, this study investigated phonological processing in reading logographic Chinese. Compound words sharing segmental templates but differing in lexical tones were used as primes and targets while their relative frequency was manipulated. It was found that tone neighbours did not prime each other significantly and the SOA of 100 msec in visual-visual priming. When the SOA was increased to 357 msec, or when primes were presented auditorily, the processing of target words was significantly delayed by their tone neighbours. Larger inhibitory effects were observed for low frequency targets with high frequency primes. It was argued that although phonological information is automatically activated and this activation affects access to semantics in reading Chinese,phonological mediation is not the only or the main ~urce of constraints on semantic activation.

  7. Carotid artery surgery (United States)

    Carotid endarterectomy; CAS surgery; Carotid artery stenosis - surgery; Endarterectomy - carotid artery ... through the catheter around the blocked area during surgery. Your carotid artery is opened. The surgeon removes ...

  8. Neurophysiological and Behavioral Responses of Mandarin Lexical Tone Processing. (United States)

    Yu, Yan H; Shafer, Valerie L; Sussman, Elyse S


    Language experience enhances discrimination of speech contrasts at a behavioral- perceptual level, as well as at a pre-attentive level, as indexed by event-related potential (ERP) mismatch negativity (MMN) responses. The enhanced sensitivity could be the result of changes in acoustic resolution and/or long-term memory representations of the relevant information in the auditory cortex. To examine these possibilities, we used a short (ca. 600 ms) vs. long (ca. 2,600 ms) interstimulus interval (ISI) in a passive, oddball discrimination task while obtaining ERPs. These ISI differences were used to test whether cross-linguistic differences in processing Mandarin lexical tone are a function of differences in acoustic resolution and/or differences in long-term memory representations. Bisyllabic nonword tokens that differed in lexical tone categories were presented using a passive listening multiple oddball paradigm. Behavioral discrimination and identification data were also collected. The ERP results revealed robust MMNs to both easy and difficult lexical tone differences for both groups at short ISIs. At long ISIs, there was either no change or an enhanced MMN amplitude for the Mandarin group, but reduced MMN amplitude for the English group. In addition, the Mandarin listeners showed a larger late negativity (LN) discriminative response than the English listeners for lexical tone contrasts in the long ISI condition. Mandarin speakers outperformed English speakers in the behavioral tasks, especially under the long ISI conditions with the more similar lexical tone pair. These results suggest that the acoustic correlates of lexical tone are fairly robust and easily discriminated at short ISIs, when the auditory sensory memory trace is strong. At longer ISIs beyond 2.5 s language-specific experience is necessary for robust discrimination.

  9. Neurophysiological and Behavioral Responses of Mandarin Lexical Tone Processing (United States)

    Yu, Yan H.; Shafer, Valerie L.; Sussman, Elyse S.


    Language experience enhances discrimination of speech contrasts at a behavioral- perceptual level, as well as at a pre-attentive level, as indexed by event-related potential (ERP) mismatch negativity (MMN) responses. The enhanced sensitivity could be the result of changes in acoustic resolution and/or long-term memory representations of the relevant information in the auditory cortex. To examine these possibilities, we used a short (ca. 600 ms) vs. long (ca. 2,600 ms) interstimulus interval (ISI) in a passive, oddball discrimination task while obtaining ERPs. These ISI differences were used to test whether cross-linguistic differences in processing Mandarin lexical tone are a function of differences in acoustic resolution and/or differences in long-term memory representations. Bisyllabic nonword tokens that differed in lexical tone categories were presented using a passive listening multiple oddball paradigm. Behavioral discrimination and identification data were also collected. The ERP results revealed robust MMNs to both easy and difficult lexical tone differences for both groups at short ISIs. At long ISIs, there was either no change or an enhanced MMN amplitude for the Mandarin group, but reduced MMN amplitude for the English group. In addition, the Mandarin listeners showed a larger late negativity (LN) discriminative response than the English listeners for lexical tone contrasts in the long ISI condition. Mandarin speakers outperformed English speakers in the behavioral tasks, especially under the long ISI conditions with the more similar lexical tone pair. These results suggest that the acoustic correlates of lexical tone are fairly robust and easily discriminated at short ISIs, when the auditory sensory memory trace is strong. At longer ISIs beyond 2.5 s language-specific experience is necessary for robust discrimination. PMID:28321179

  10. Player Collaboration in the Explorative Sound Environment ToneInk

    DEFF Research Database (Denmark)

    Hansen, Anne-Marie S.; Andersen, Hans Jørgen; Raudaskoski, Pirkko Liisa


    In the present paper, ToneInk, a prototype of a music based play scenario that investigates player collaboration, is introduced. ToneInk is an explorative sound environment that differs from the majority of music based games in that players can collaborate and be creative in the way they express...... mutual awareness, and in general were more passive when they needed to monitor a screen interface that supported the sound environment. Player collaboration was strongest when players negotiated rhythm, while the negotiation of melody was temporally offset and consisted of long individual explorations....

  11. Effects of catechins on vascular tone in rat thoracic aorta with endothelium. (United States)

    Sanae, Fujiko; Miyaichi, Yukinori; Kizu, Haruhisa; Hayashi, Hisao


    The effects of eight catechin derivatives on vascular tone in rat thoracic aorta were examined. Catechin derivatives (10 microM) potentiated the contractile response to phenylephrine in endothelium-intact arteries. The potentiations produced by EGCg and EGC were almost absent in endothelium-denuded arteries and abolished by N(G)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis. The catechin derivatives also inhibited endothelium-dependent relaxation in response to acetylcholine. The order of catechin derivatives ranked in terms of both increasing vascular reactivity and impairing endothelium-dependent relaxation was similar; (-)-gallocatechin (GC) >or= (-)-epigallocatechin (EGC) >or= (-)-gallocatechin gallate (GCg) >or= (-)-epigallocatechin gallate (EGCg) >or= (-)-catechin (C) >or= (-)-epicatechin (EC) >or= (-)-catechin gallate (Cg) >or= (-)-epicatechin gallate (ECg). In addition, EGC inhibited the endothelium-independent relaxation evoked by both sodium nitroprusside and NOC-7, a spontanous NO releaser, but EGCg inhibited only that by NOC-7. These findings indicate that catechin derivatives produce a potentiation of the contractile response and an inhibition of the vasorelaxant response, probably through inactivation of endothelium-derived nitric oxide (NO), and that the hydroxyl on C-5 of the B ring together with the stereoscopic structure between the C-3 group and the B ring of flavanols was of importance in mediating the above effects and that the substitution of a gallate group of C-3 attenuated the effects, probably due to a decreased response to solube guanylate cyclase in vascular smooth muscle cells.

  12. Intermittent hypoxia in rats reduces activation of Ca2+ sparks in mesenteric arteries. (United States)

    Jackson-Weaver, Olan; Osmond, Jessica M; Naik, Jay S; Gonzalez Bosc, Laura V; Walker, Benjimen R; Kanagy, Nancy L


    Ca(+) sparks are vascular smooth muscle cell (VSMC) Ca(2+)-release events that are mediated by ryanodine receptors (RyR) and promote vasodilation by activating large-conductance Ca(2+)-activated potassium channels and inhibiting myogenic tone. We have previously reported that exposing rats to intermittent hypoxia (IH) to simulate sleep apnea augments myogenic tone in mesenteric arteries through loss of hydrogen sulfide (H2S)-induced dilation. Because we also observed that H2S can increase Ca(2+) spark activity, we hypothesized that loss of H2S after IH exposure reduces Ca(2+) spark activity and that blocking Ca(2+) spark generation reduces H2S-induced dilation. Ca(2+) spark activity was lower in VSMC of arteries from IH compared with sham-exposed rats. Furthermore, depolarizing VSMC by increasing luminal pressure (from 20 to 100 mmHg) or by elevating extracellular [K(+)] increased spark activity in VSMC of arteries from sham rats but had no effect in arteries from IH rats. Inhibiting endogenous H2S production in sham arteries prevented these increases. NaHS or phosphodiesterase inhibition increased spark activity to the same extent in sham and IH arteries. Depolarization-induced increases in Ca(2+) spark activity were due to increased sparks per site, whereas H2S increases in spark activity were due to increased spark sites per cell. Finally, inhibiting Ca(2+) spark activity with ryanodine (10 μM) enhanced myogenic tone in arteries from sham but not IH rats and blocked dilation to exogenous H2S in arteries from both sham and IH rats. Our results suggest that H2S regulates RyR activation and that H2S-induced dilation requires Ca(2+) spark activation. IH exposure decreases endogenous H2S-dependent Ca(2+) spark activation to cause membrane depolarization and enhance myogenic tone in mesenteric arteries.

  13. Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteries

    DEFF Research Database (Denmark)

    Ploug, Kenneth Beri; Edvinsson, Lars; Olesen, Jes;


    ATP-sensitive potassium (K(ATP)) channels play an important role in the regulation of cerebral vascular tone. In vitro studies using synthetic K(ATP) channel openers suggest that the pharmacological profiles differ between rat basilar arteries and rat middle cerebral arteries. To address this issue....... Densitometric measurements of the Western blot signals further showed higher expression levels of Kir6.1 and SUR2B proteins in rat middle cerebral arteries than was found in rat basilar arteries. In conclusion, our in vitro pharmacological studies showed no evidence for functional endothelial K(ATP) channels...

  14. Coronary artery fistula (United States)

    Congenital heart defect - coronary artery fistula; Birth defect heart - coronary artery fistula ... A coronary artery fistula is often congenital, meaning that it is present at birth. It generally occurs when one of the coronary arteries ...

  15. Contractility studies on isolated bovine choroidal small arteries: determination of the active and passive wall tension-internal circumference relation. (United States)

    Delaey, C; Boussery, K; Van de Voorde, J


    Studies on isolated choroidal arteries could help to understand the regulatory mechanisms in the choroidal circulation. The aim of the present study was therefore to assess whether contractility studies on isolated choroidal arteries were feasible and to determine the active and passive wall tension-internal circumference relation of these arteries. This relation is essential for reliable further pharmacodynamic studies on these vessels. Isolated choroidal arteries were mounted on a wire myograph for isometric tension recording. After the vessel was mounted, the L(100) (the circumference of the vessel at a transmural pressure of 100 mmHg) was determined. Then the passive and active wall tension-internal circumference relation of the choroidal vessels was obtained by stepwise increasing the internal circumference. The changes in the internal circumference were expressed as a percentage of L(100). After each increase in circumference, the passive tone (in a calcium free medium), the spontaneous tone (in a Krebs--Ringer bicarbonate solution) and the active tone (in a solution containing K(+) 120 mM and prostaglandin F(2 alpha) 30 microM) was measured. The passive tone of the vessel increased exponentially with the circumference of the vessel. Both the spontaneous tone and the active tone also increased when the vessel was stretched. They peaked when the internal circumference approached 90% of the L(100) and diminished again when the circumference was further increased. The peak value of the active tension curve averaged 2.24+/-0.47 Nm(-1) (n=10). The passive tension was 0.57+/-0.08 Nm(-1) (n=10) at this circumference. The peak value of the spontaneous tension curve averaged 0.37+/-0.08 Nm(-1) (n=10). It can be concluded that in vitro contractility studies on isolated choroidal arteries are feasible. The optimal length or preload of the choroidal arteries is attained when the internal circumference of the artery is set to 90% of the L(100).

  16. Parc automobile et effet de serre. Agir sur le parc automobile pour réduire l’effet de serre


    Cauret, Lionel; Crozet, Yves; Darbéra, Richard; Faudry, Daniel; Golovtchenko, Nicolas; MIRABEL François; Nicolas, Jean-Pierre; Simon, Benoît; Zélem, Marie-Christine


    International audience; Cette étude traite des conditions du renouvellement du parc automobile afin de mieux maîtriser l'impact sur l'effet de serre. Quels sont les critères d'achat et les conditions d'utilisation des véhicules ? Quelles politiques publiques peuvent orienter le choix des consommateurs et l'offre des constructeurs vers des véhicules moins polluants ? Divers instruments de politiques publiques sont analysés.



    Nguyen, Huu Thanh Tam; Hattab-Christmann, Malika; Med KECHIDI (LEREPS-GRES)


    Cet article se propose d’étudier l’impact de l’investissement direct étranger de plateforme d’exportation sur la production industrielle locale. L’influence de ce type d’investissement est vue à travers l’effet de concurrence et les retombées technologiques. Le modèle analytique proposé aboutit à des résultats conditionnels. Ce type d’investissement peut mener à des sorties nettes de firmes domestiques ainsi qu’à une baisse de leur taille. C’est le cas quand celles-ci sont relativement peu pe...

  18. The Role of Tone in Some Cushitic Languages. (United States)

    Appleyard, David L.


    The morphological function of tone/accent is examined in a number of Cushitic languages, with the objective of determining whether any comparative statement can be made validly at the group level. Three languages, the Somali dialect cluster, Afar, and Oromo, are the basis for the study. Patterns in case, gender, and the jussive form are analyzed.…

  19. Context, Contrast, and Tone of Voice in Auditory Sarcasm Perception (United States)

    Voyer, Daniel; Thibodeau, Sophie-Hélène; Delong, Breanna J.


    Four experiments were conducted to investigate the interplay between context and tone of voice in the perception of sarcasm. These experiments emphasized the role of contrast effects in sarcasm perception exclusively by means of auditory stimuli whereas most past research has relied on written material. In all experiments, a positive or negative…

  20. Fan Noise Source Diagnostic Test: Tone Modal Structure Results (United States)

    Heidelberg, Laurence J.


    This investigation is part of a test series that was extremely comprehensive and included aerodynamic and acoustic testing of a fan stage using two different fan rotors and three different stator designs. The test series is known as the Source Diagnostic Test (SDT) and was conducted by NASA Glenn as part of the Advanced Subsonic Technology (AST) Noise Reduction Program. Tone mode measurements of one of the rotors with three different stators were made. The stator designs involve changes in vane count and sweep at constant solidity. The results of both inlet and exhaust tone mode measurements are presented in terms of mode power for both circumferential and radial mode orders. The results show benefits of vane sweep to be large, up to 13 dB in total tone power. At many conditions, the increase in power due to cutting on the rotor/stator interaction is more than offset by vane sweep. The rotor locked mode is shown as an important contributor to tone power when the blade tip speed is near and above Mach one. This is most evident in the inlet when the direct rotor field starts to cut on.

  1. Representing morphological tone in a computational grammar of Hausa

    Directory of Open Access Journals (Sweden)

    Berthold Crysmann


    Full Text Available In this paper I shall discuss the representation of morphological tone in Hausa, as implemented in a computational grammar of the language, referred to as HaG, which has been developed within the framework of Head-driven Phrase Structure Grammar. Based on an in-depth study of segmental and suprasegmental properties manipulated by morphological processes, I shall argue that two fundamental insights from Autosegmental Phonology needs to be seamlessly integrated into typed feature structure grammars of languages with grammatical tone, namely (i the systematic separation of tonal and metrical information from the string of consonants and vowels, and (ii the possibility of tonal spreading, i.e. the possibility for a tonal specification to be assigned to an arbitrary number of adjacent tone-bearing units (syllables. To this end, I present a formalisation of tonal melodies in terms of typed list constraints that implement a notion of tonal spreading, allowing for an underspecified description of tonal melodies, independent of the number of tone-bearing units. I shall finally show that this minimal encoding is sufficient and flexible enough to capture the range of suprasegmental phenomena in Hausa.

  2. Woodwind Tone Hole Acoustics and the Spectrum Transformation Function. (United States)

    Keefe, Douglas Howard

    This report describes an investigation of woodwind musical instrument tone holes and their effect on the radiated spectrum, the total dissipation, the stability of oscillation, the psychoacoustical cues important in perception, and the tuning and response of the instrument. Varying tone hole proportions significantly affect the radiative and frictional damping near a single hole, the mutual interactions between holes, the onset of streaming and turbulence near the holes, and the perceived woodwind timbre. The interconnections between related fields are explored through a brief review of sound production in woodwinds plus more extensive reviews of room and psychological acoustics. A theoretical and experimental discussion of the spectrum transformation function from the mouthpiece into the room relates all these fields. Also, considered are differences between cylindrical and conical bore woodwinds, the systematic shifts in saxophone spectra produced by the beating of the reed, the coupling of many closely spaced tone holes to the room excitation, the role of the player, and the results pertaining to computer music synthesis. The complicated acoustical flow inside the main air column near a single tone hole has been examined using a Green function, integral equation approach. A variational formulation allows explicit calculation of the open and closed hole impedance parameters needed in the transmission line description of a woodwind, and experiments have verified the theory in detail. Major acoustical topics considered are listed below. The effective length t(,e) of an open hole, relevant for instrument design and modification, is calculated and measured in terms of the main bore diameter 2a, hole diameter 2b, and the height t of the hole chimney; the effect of a hanging pad is a semi-empirical correction on t(,e). When the fundamental plane-wave mode of the main air column oscillation is at a pressure node, both the open and closed hole series impedances are

  3. Transonic Tones and Excess Broadband Noise in Overexpanded Supersonic Jets (United States)

    Zaman, Khairul B. M. Q.


    Noise characteristics of convergent-divergent (C-D) nozzles in the overexpanded regime are the focus of this paper. The flow regime is encountered during takeoff and landing of certain airplanes and also with rocket nozzles in launch-pad environment. Experimental results from laboratory-scale single nozzles are discussed. The flow often undergoes a resonance accompanied by emission of tones (referred to as transonic tones). The phenomenon is different from the well-known screech tones. Unlike screech, the frequency increases with increasing supply pressure. There is a staging behavior odd harmonic stages occur at lower pressures while the fundamental occurs in a range of relatively higher pressures. A striking feature is that tripping of the nozzle s internal boundary layer tends to suppress the resonance. However, even in the absence of tones the broadband levels are found to be high. That is, relative to a convergent case and at same pressure ratio, the C-D nozzles are found to be noisier, often by more than 10dB. This excess broadband noise (referred to as EBBN) is further explored. Its characteristics are found to be different from the well-known broadband shockassociated noise ( BBSN ). For example, while the frequency of the BBSN peak varies with observation angle no such variation is noted with EBBN. The mechanisms of the transonic tone and the EBBN are not completely understood yet. They appear to be due to unsteady shock motion inside the nozzle. The shock drives the flow downstream like a vibrating diaphragm, and resonance takes place similarly as with acoustic resonance of a conical section having one end closed and the other end open. When the boundary layer is tripped, apparently a breakdown of azimuthal coherence suppresses the resonance. However, there is still unsteady shock motion albeit with superimposed randomness. Such random motion of the internal shock and its interaction with the separated boundary layer produces the EBBN.

  4. Lexical tone and stuttering loci in Mandarin: evidence from preschool children who stutter. (United States)

    Chou, Fang-Chi; Zebrowski, Patricia; Yang, Shu-Lan


    The purpose of this study was to examine the relationship between stuttering loci and lexical tone in Mandarin-speaking preschoolers. Conversational samples from 20 Taiwanese children who stutter (CWS; M = 4:9; range = 3:2-6:4) were analysed for frequency and type of speech disfluency and lexical tone associated with stuttering-like disfluencies (SLDs). Results indicated that SLDs were significantly more likely to be produced on Mandarin syllables carrying Tone 3 and Tone 4 syllables compared to syllables carrying either Tone 1 or Tone 2. Post-hoc analyses revealed: (1) no significant differences in the stuttering frequencies between Tone 1 and Tone 2, or between Tone 3 and Tone 4, and (2) a higher incidence of stuttering on syllables carrying Tone 3 and Tone 4 embedded in conflicting (as opposed to compatible) tonal contexts. Results suggest that the higher incidence of stuttering on Mandarin syllables carrying either Tone 3 or 4 may be attributed to the increased level of speech motor demand underlying rapid F0 change both within and across syllables.

  5. Implicit target substitution and sequencing for lexical tone production in Chinese: an FMRI study. (United States)

    Chang, Hui-Chuan; Lee, Hsin-Ju; Tzeng, Ovid J L; Kuo, Wen-Jui


    In this study, we examine the neural substrates underlying Tone 3 sandhi and tone sequencing in Mandarin Chinese using fMRI. Tone 3 sandhi is traditionally described as the substitution of Tone 3 with Tone 2 when followed by another Tone 3 (i.e., 33→23). According to current speech production models, target substitution is expected to engage the posterior inferior frontal gyrus. Since Tone 3 sandhi is, to some extent, independent of segments, which makes it more similar to singing, right-lateralized activation in this region was predicted. As for tone sequencing, based on studies in sequencing, we expected the involvement of the supplementary motor area. In the experiments, participants were asked to produce twelve four-syllable sequences with the same tone assignment (the repeated sequences) or a different tone assignment (the mixed sequences). We found right-lateralized posterior inferior frontal gyrus activation for the sequence 3333 (Tone 3 sandhi) and left-lateralized activation in the supplementary motor area for the mixed sequences (tone sequencing). We proposed that tones and segments could be processed in parallel in the left and right hemispheres, but their integration, or the product of their integration, is hosted in the left hemisphere.

  6. Implicit target substitution and sequencing for lexical tone production in Chinese: an FMRI study.

    Directory of Open Access Journals (Sweden)

    Hui-Chuan Chang

    Full Text Available In this study, we examine the neural substrates underlying Tone 3 sandhi and tone sequencing in Mandarin Chinese using fMRI. Tone 3 sandhi is traditionally described as the substitution of Tone 3 with Tone 2 when followed by another Tone 3 (i.e., 33→23. According to current speech production models, target substitution is expected to engage the posterior inferior frontal gyrus. Since Tone 3 sandhi is, to some extent, independent of segments, which makes it more similar to singing, right-lateralized activation in this region was predicted. As for tone sequencing, based on studies in sequencing, we expected the involvement of the supplementary motor area. In the experiments, participants were asked to produce twelve four-syllable sequences with the same tone assignment (the repeated sequences or a different tone assignment (the mixed sequences. We found right-lateralized posterior inferior frontal gyrus activation for the sequence 3333 (Tone 3 sandhi and left-lateralized activation in the supplementary motor area for the mixed sequences (tone sequencing. We proposed that tones and segments could be processed in parallel in the left and right hemispheres, but their integration, or the product of their integration, is hosted in the left hemisphere.

  7. Perceptual evidence for protracted development in monosyllabic Mandarin lexical tone production in preschool children in Taiwan. (United States)

    Wong, Puisan


    This study used the same methodology in Wong [J. Speech Lang. Hear. Res. 55, 1423-1437 (2012b)] to examine the perceived accuracy of monosyllabic Mandarin tones produced by 4- and 5-year-old Mandarin-speaking children growing up in Taiwan and combined the findings with those of 3-year-olds reported in Wong [J. Speech Lang. Hear. Res. 55, 1423-1437 (2012b)] to track the development of monosyllabic tone production in preschool children. Tone productions of adults and children were collected in a picture naming task and low-pass filtered to remove lexical information and reserve tone information. Five native-speakers categorized the target tones in the filtered productions. Children's tone accuracy was compared to adults' to determine mastery and developmental changes. The results showed that preschool children in Taiwan have not fully mastered the production of monosyllabic Mandarin tones. None of the tones produced by the children in the three age groups reached adult-like accuracy. Little developmental change was found in children's tone accuracy during the preschool years. A similar order of accuracy of the tones was observed across the three age groups and the order appeared to follow the order of articulatory complexity in producing the tones. The findings suggest a protracted course of development in children's acquisition of Mandarin tones and that tone development may be constrained by physiological factors.

  8. Les émissions de CO2 et autres gaz à effets de serre

    Directory of Open Access Journals (Sweden)

    François Durand-Dastès


    Full Text Available Cette note envisage les composantes explicatives des émissions de Gaz à effet de serre : coefficient d’émission par habitant et par unité monétaire de PNB, effets des masses de population et de production. La part de ces derniers est parfois curieusement sous estimée dans la littérature, et il semble nécessaire d’insister sur leur rôle majeur. Après une présentation cartographique et graphique de quelques données essentielles, on se livre à une expérimentation prospective à partir de ces données et des objectifs couramment mentionnés dans les accords internationaux. On cherche à en tirer quelques leçons.

  9. Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries

    DEFF Research Database (Denmark)

    Qian, Xun; Francis, Michael; Köhler, Ralf;


    Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients from internal...

  10. Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure : instantaneous counteraction by acute AT(1) receptor blockade

    NARCIS (Netherlands)

    Gschwend, S; Henning, RH; Pinto, YM; de Zeeuw, D; van Gilst, WH; Buikema, H


    1 Increased vascular resistance in chronic heart failure (CHF) has been attributed to stimulated neurohumoral systems. However, local mechanisms may also importantly contribute to set arterial tone. Our aim, therefore, was to test whether pressure-induced myogenic constriction of resistance arteries

  11. The intensitive DL of tones: dependence of signal/masker ratio on tone level and on spectrum of added noise. (United States)

    Greenwood, D D


    In Greenwood [J. Acoust. Soc. Am. 33, 484-502 (1961a)] the ratio of masked signal threshold to masker level (S/M) decreased about 4 dB at a masker level of about 50 dB SL, the 'transition' level, when noise bands were subcritical but not when supercritical. Schlauch et al. [J. Acoust. Soc. Am. 71, S73 (1982)] report a related result. A pilot study [Greenwood, Harvard Psychoacoustic Lab. Status Report 37, 8-9 (1961)] in which pure tones masked identical tones in-phase showed a larger change in S/M. Detailed tone-tone growth-of-masking curves from over a dozen subjects in 1967-69, and in 1960, are reported here. A transition in slope, of variable abruptness, often begins to occur at about 50 dB SL, dropping S/M ratio by 6 to 8 dB or more [Rabinowitz et al., J. Acoust. Soc. Am. 35, 1053 (1976)]; the curves sometimes possess two segments, sometimes are simply convex. All have overall slopes less than 1.0, known also as the 'near miss'. Consistent with other results [Zwicker, Acustica 6, 365-396 (1956); Viemeister, J. Acoust. Soc. Am. 51, 1265-1296 (1972); Moore and Raab, J. Acoust. Soc. Am. 55, 1049-1060 (1974)], addition of low-level wide-band and high-pass noise was found to counteract the change in S/M, i.e., to raise the high-level section of the growth-of-masking curve. However, the ability of narrow 'band-pass' noise to exert this effect was greatest when added at a frequency ratio (band/masking-tone) of 1.3 to 1.5, which seems more closely to link the effects of added noise to the effects of increasing a masking band from sub- to supercritical width (above). Interpretation of the decrease in DL with level begins by noting that the 'transition' level correlates approximately with the level at which a primary unit population excited by a given pure tone begins rapidly to expand basally. Underlying this, the basalward shift of a tone's displacement envelope peak accelerates at about the same level [Rhode, J. Acoust. Soc. Am. 49, 1218-1231 (1971); Sellick et al., J

  12. Effects of intracellular alkalinization on resting and agonist-induced vascular tone. (United States)

    Danthuluri, N R; Deth, R C


    To evaluate the influence of intracellular alkalinization on basal and agonist-induced vascular tone, we studied the effect of NH4Cl on rat aorta. NH4Cl induced a gradually developing contraction in a dose-dependent manner. Although the contractile response to 20 mM NH4Cl was associated with a latent period (LP) of 23.4 +/- 2.8 min, intracellular pH (pHi) measurements in cultured rat aortic smooth muscle cells showed that NH4Cl-induced intracellular alkalinization was immediate and transient, returning to basal pHi levels in about 30-35 min. Agents that elevate Ca2+, such as A23187 and high KCl, significantly reduced the LP associated with 20 mM NH4Cl-induced contraction. NH4Cl-induced contractions were sensitive to extracellular Ca2+ removal and to the addition of forskolin (1 microM); however, NH4Cl by itself did not cause Ca2+-influx as shown by 45Ca-uptake studies. Addition of 20 mM NH4Cl to precontracted tissues resulted in a transient relaxation, which was complete in approximately 10 min, followed by a contraction above the original level of tone. NH4Cl pretreatment caused time-dependent alterations in both the rapid and slow phases of phenylephrine and angiotensin II contractions. Rapid-phase of phenylephrine and angiotensin II contractions. Rapid-phase responses were diminished at shorter NH4Cl incubation times (10 min), whereas slow-phase response was augmented after a longer incubation (20 min). Overall, the vasorelaxant and vasoconstrictor effects induced by NH4Cl suggest a complex relationship between intracellular alkalinization and arterial contractility.

  13. Effects of production training and perception training on lexical tone perception--A behavioral and ERP study. (United States)

    Lu, Shuang; Wayland, Ratree; Kaan, Edith


    The present study recorded both behavioral data and event-related brain potentials to examine the effectiveness of a perception-only training and a perception-plus-production training procedure on the intentional and unintentional perception of lexical tone by native English listeners. In the behavioral task, both the perception-only and the perception-plus-production groups improved on the tone discrimination abilities after the training session. Moreover, the participants in both groups generalized the improvements gained through the trained stimuli to the untrained stimuli. In the ERP task, the Mismatch Negativity was smaller in the post-training task than in the pre-training task. However, the two training groups did not differ in tone processing at the intentional or unintentional level after training. These results suggest that the employment of the motor system does not specifically benefit the tone perceptual skills. Furthermore, the present study investigated whether some tone pairs are more easily confused than others by native English listeners, and whether the order of tone presentation influences non-native tone discrimination. In the behavioral task, Tone2-Tone1 (rising-level) and Tone2-Tone4 (rising-falling) were the most difficult tone pairs, while Tone1-Tone2 and Tone4-Tone2 were the easiest tone pairs, even though they involved the same tone contrasts respectively. In the ERP task, the native English listeners had good discrimination when Tone2 and Tone4 were embedded in strings of Tone1, while poor discrimination when Tone1 was inserted in the context of Tone2 or Tone4. These asymmetries in tone perception might be attributed to the interference of native intonation system and can be altered by training.

  14. "Mirror, mirror...." a preliminary investigation of skin tone dissatisfaction and its impact among British adults. (United States)

    Swami, Viren; Henry, Amy; Peacock, Nicola; Roberts-Dunn, Ahkin; Porter, Alan


    This study examined skin tone dissatisfaction, measured using a skin tone chart, among a multiethnic sample of British adults. A total of 648 British White individuals, 292 British South Asians, and 260 British African Caribbean participants completed a visual task in which they were asked to indicate their actual and ideal skin tones. They also completed measures of body appreciation, self-esteem, and ethnic identity attachment. Results showed that Asians had a lighter skin tone ideal than White and African Caribbean participants. Conversely, White participants had higher skin tone dissatisfaction (preferring a darker skin tone) than Asian and African Caribbean participants, who preferred a lighter skin tone. Results also showed that skin tone dissatisfaction predicted body appreciation once the effects of participant ethnicity, age, ethnic identity attachment, and self-esteem had been accounted for. Implications of our findings and suggestions for future research are discussed.

  15. Potassium channels in pulmonary arterial hypertension. (United States)

    Boucherat, Olivier; Chabot, Sophie; Antigny, Fabrice; Perros, Frédéric; Provencher, Steeve; Bonnet, Sébastien


    Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with various origins. All forms of PAH share a common pulmonary arteriopathy characterised by vasoconstriction, remodelling of the pre-capillary pulmonary vessel wall, and in situ thrombosis. Although the pathogenesis of PAH is recognised as a complex and multifactorial process, there is growing evidence that potassium channels dysfunction in pulmonary artery smooth muscle cells is a hallmark of PAH. Besides regulating many physiological functions, reduced potassium channels expression and/or activity have significant effects on PAH establishment and progression. This review describes the molecular mechanisms and physiological consequences of potassium channel modulation. Special emphasis is placed on KCNA5 (Kv1.5) and KCNK3 (TASK1), which are considered to play a central role in determining pulmonary vascular tone and may represent attractive therapeutic targets in the treatment of PAH.

  16. Perception of Mandarin Tones: The Effect of L1 Background and Training (United States)

    Wang, Xinchun


    This study investigates whether native Hmong speakers' first language (L1) lexical tone experience facilitates or interferes with their perception of Mandarin tones and whether training is effective for perceptual learning of second (L2) tones. In Experiment 1, 3 groups of beginning level learners of Mandarin with different L1 prosodic background…

  17. Analytical Solution and Numerical Simulation of Real-Time Dispersion Monitoring Using Tone Subcarrier

    Institute of Scientific and Technical Information of China (English)

    HUANG He; CHEN Fushen; JIANG Yi


    A method for online dispersion monitoring by adding a single in-band subcarrier tone is introduced. According to the theoretical analysis, the dispersion monitor and measurement range are determined by the specific frequency of the subcarrier tone. By using simulation tools, figures about relationship between power of subcarrier tone and transmission distance in ideal condition are shown.

  18. Physiological Self-Regulation and Information Processing in Infancy: Cardiac Vagal Tone and Habituation. (United States)

    Bornstein, Marc H.; Suess, Patricia E.


    Investigated the role of physiological self-regulation (cardiac vagal tone) in information processing (habituation) in infants. Found that decreases in vagal tone consistently related to habituation efficiency at 2 and 5 months. Within- and between- age suppression of vagal tone predicted accumulated looking time (ALT), but ALT did not predict…

  19. Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex. (United States)

    Shetake, Jai A; Engineer, Navzer D; Vrana, Will A; Wolf, Jordan T; Kilgard, Michael P


    The selectivity of neurons in sensory cortex can be modified by pairing neuromodulator release with sensory stimulation. Repeated pairing of electrical stimulation of the cholinergic nucleus basalis, for example, induces input specific plasticity in primary auditory cortex (A1). Pairing nucleus basalis stimulation (NBS) with a tone increases the number of A1 neurons that respond to the paired tone frequency. Pairing NBS with fast or slow tone trains can respectively increase or decrease the ability of A1 neurons to respond to rapidly presented tones. Pairing vagus nerve stimulation (VNS) with a single tone alters spectral tuning in the same way as NBS-tone pairing without the need for brain surgery. In this study, we tested whether pairing VNS with tone trains can change the temporal response properties of A1 neurons. In naïve rats, A1 neurons respond strongly to tones repeated at rates up to 10 pulses per second (pps). Repeatedly pairing VNS with 15 pps tone trains increased the temporal following capacity of A1 neurons and repeatedly pairing VNS with 5 pps tone trains decreased the temporal following capacity of A1 neurons. Pairing VNS with tone trains did not alter the frequency selectivity or tonotopic organization of auditory cortex neurons. Since VNS is well tolerated by patients, VNS-tone train pairing represents a viable method to direct temporal plasticity in a variety of human conditions associated with temporal processing deficits.

  20. Perception and Production of Lexical Tones by 3-Year-Old, Mandarin-Speaking Children (United States)

    Wong, Puisan; Schwartz, Richard G.; Jenkins, James J.


    The present study investigated 3-year-old children's perception and production of Mandarin lexical tones in monosyllabic words. Thirteen 3-year-old, Mandarin-speaking children participated in the study. Tone perception was examined by a picture-pointing task, and tone production was investigated by picture naming. To compare children's productions…

  1. An Annotated Bibliography on Tone. UCLA Working Papers in Phonetics 28. (United States)

    Maddieson, Ian, Comp.; Gandour, Jack, Comp.

    This annotated bibliography, which has been entered into the SOLAR Bibliography File, focuses on the phonetics and phonology of tone, including studies on the physiology of phonation and pitch control, pitch perception, inherent pitch of vowels, the interaction of tone with musical melody in tone languages, and other related issues. An attempt has…

  2. Influences of Vowel and Tone Variation on Emergent Word Knowledge: A Cross-Linguistic Investigation (United States)

    Singh, Leher; Hui, Tam Jun; Chan, Calista; Golinkoff, Roberta Michnick


    To learn words, infants must be sensitive to native phonological contrast. While lexical tone predominates as a source of phonemic contrast in human languages, there has been little investigation of the influences of lexical tone on word learning. The present study investigates infants' sensitivity to tone mispronunciations in two groups of…

  3. Tones inferior to eye movements in the EMDR treatment of PTSD. (United States)

    van den Hout, Marcel A; Rijkeboer, Marleen M; Engelhard, Iris M; Klugkist, Irene; Hornsveld, Hellen; Toffolo, Marieke J B; Cath, Danielle C


    Eye Movement Desensitization and Reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder (PTSD). During EMDR, patients make eye movements (EMs) while recalling traumatic memories, but recently therapists have replaced EMs by alternating beep tones. There are no outcome studies on the effects of tones. In an earlier analogue study, tones were inferior to EMs in the reduction of vividness of aversive memories. In a first EMDR session, 12 PTSD patients recalled trauma memories in three conditions: recall only, recall + tones, and recall + EMs. Three competing hypotheses were tested: 1) EMs are as effective as tones and better than recall only, 2) EMs are better than tones and tones are as effective as recall only, and 3) EMs are better than tones and tones are better than recall only. The order of conditions was balanced, each condition was delivered twice, and decline in memory vividness and emotionality served as outcome measures. The data strongly support hypothesis 2 and 3 over 1: EMs outperformed tones while it remained unclear if tones add to recall only. The findings add to earlier considerations and earlier analogue findings suggesting that EMs are superior to tones and that replacing the former by the latter was premature.

  4. Effects of Fundamental Frequency and Duration Variation on the Perception of South Kyungsang Korean Tones (United States)

    Chang, Seung-Eun


    The perception of lexical tones is addressed through research on South Kyungsang Korean, spoken in the southeastern part of Korea. Based on an earlier production study (Chang, 2008a, 2008b), a categorization experiment was conducted to determine the perceptually salient aspects of the perceptual nature of a high tone and a rising tone. The…

  5. Child and Mother Cardiac Vagal Tone: Continuity, Stability, and Concordance across the First 5 Years. (United States)

    Bornstein, Marc H.; Suess, Patricia E.


    Measured vagal tone and heart period at 2 months and 5 years in children and their mothers to evaluate the development of vagal regulation at rest and during an environmental task. Found that children reached adult levels of baseline vagal tone by 5 years and did not differ from mothers in baseline-to-task change in vagal tone or heart period.…

  6. Dynamic properties of excitation and two-tone inhibition in the cochlear nucleus studied using amplitude-modulated tones. (United States)

    Moller, A R


    The dynamic properties of excitation and two-tone inhibition in the cochlear nucleus were studied from extracellularly recorded unit responses to two simultaneously presented tones. One tone was presented at the unit's characteristic frequency, CF, the other at the unit's best inhibitory frequency, BIF. One or both of the tones were amplitude-modulated with pseudorandom noise. The system under study is in general nonlinear, but can be considered to function as a linear system for small changes in sound intensity around a certain operating point. The dynamic properties are likely to be different at different operating points. A suitable method for the study of dynamic properties of such a system employs tones that are amplitude-modulated with pseudorandom noise. In the present study, the dynamic properties were assessed by cross-correlating the unit discharge rate with the modulation. This was accomplished by computing the cross-covariance function between a period of noise and a period histogram of the discharges, the histogram being locked to the periodicity of the pseudorandom noise. In this way, it has been shown in previous works (Moller, 1973, 1974b), that the cross-covariance function is a valid approximation of the system's impulse response function at a certain sound intensity, provided the modulation is kept at a low value. In the present study the computed cross-covariance function is thus an approximation of the change in discharge rate of the cochlear nucleus units in response to a brief increase in stimulus intensity. As the response of the system under the given circumstances is approximately that of a linear system, the integrated cross-covariance is an approximation of the system's step response function, i.e the change in discharge rate that resulte from a hypothetical step increase in stimulus intensity. The results of the present study can be summarized as follows: 1. The impulse and step response functions computed from the responses to the

  7. Modulation masking produced by complex-tone modulators

    DEFF Research Database (Denmark)

    Ewert, Stephan; Verhey, J.L.; Dau, Torsten


    Thresholds were measured for detecting sinusoidal amplitude modulation in the presence of a complex-tone masker modulation. Both modulations were applied to the same sinusoidal carrier. Two different masker modulations were used: (i) a pair of components beating at the difference frequency and (ii......) a three-tone complex producing a sinusoidal amplitude modulation of the modulation depth at the difference frequency between adjacent components. Both maskers show a periodicity in the waveform that is not contained in the envelope spectrum itself but can be observed when the envelope of the envelope......, referred to as the "venelope" [Ewert et al., J. Acoust. Soc. Am. 112. 2921-2931 (2002)], is calculated. For a signal frequency equal to the masker-venelope periodicity, modulation depth at threshold was measured as a function of the signal phase relative to the phase of the masker-venelope component...

  8. Modulation of motor excitability by metricality of tone sequences

    DEFF Research Database (Denmark)

    Cameron, David; Stewart, Lauren; Pearce, Marcus


    amplitude. These results demonstrate that the pure metrical structure of an auditory rhythm presented as generic parametrically varied tone sequences can influence motor excitability but that the picture may be more complex for real recordings of musical pieces. (PsycINFO Database Record (c) 2013 APA, all......When listening to music, humans tend to synchronize their movements with the perceived beat (e.g., foot-tapping). Brain areas associated with motor function have been closely linked to the perception of beat and rhythm, but the mechanism of this temporal auditory–motor coupling is not fully...... sequences or music. When TMS pulses were delivered synchronously with perceptible beats in the metrically strong tone sequences, MEPs had greater amplitude than for metrically weak sequences. In contrast, for music that gave a strong or weak sense of the underlying beat, there were no differences in MEP...

  9. Complex-tone pitch representations in the human auditory system

    DEFF Research Database (Denmark)

    Bianchi, Federica; Dau, Torsten; Santurette, Sébastien;

    , specifically those showing enhanced pitch cues (i.e., musicians) and those typically having disrupted pitch cues (i.e., hearing-impaired listeners). In particular, two main topics were addressed: the relative importance of resolved and unresolved harmonics for normal-hearing (NH) and hearing-impaired (HI......) listeners and the effect of musical training for pitch discrimination of complex tones with resolved and unresolved harmonics. Concerning the first topic, behavioral and modeling results in listeners with sensorineural hearing loss (SNHL) indicated that temporal envelope cues of complex tones...... discrimination to that of NH listeners. In the second part of this work, behavioral and objective measures of pitch discrimination were carried out in musicians and non-musicians. Musicians showed an increased pitch-discrimination performance relative to non-musicians for both resolved and unresolved harmonics...

  10. Gray tone image watermarking with complementary computer generated holography. (United States)

    Martinez, Christophe; Laulagnet, Fabien; Lemonnier, Olivier


    We present herein an original approach for the watermarking of holograms in gray tone images for use in microscopic halftone image archiving. Our concept is based on the principle of complementary holography presented in a previous contribution. The efficiency of the concept is evaluated theoretically and experimentally. We demonstrate the interest of elliptical diffraction patterns as an alternative to the usual rectangular diffraction patterns and confirm the subsidiary role of the hologram amplitude in the hologram recovery process.

  11. The Effect of Structured Contextual Tones on Psychophysical Frequency Discrimination. (United States)


    The absence of timbre and Musical structure, as well as the short-duration of the tones in the current experiment certainly contribute to the absence...contextual constraints top-down processing 20. ABSTRACT (Continua a evee side Of nooeceep muW Identify S b eaki nobo) ---->Six musically and six non- musically ...patterns in the structured condition were arranged to reflect structural rules. Musical training made no difference, but magnitude of the frequency

  12. Affective tone of mothers' statements to restrict their children's eating. (United States)

    Pesch, Megan H; Miller, Alison L; Appugliese, Danielle P; Rosenblum, Katherine L; Lumeng, Julie C


    Maternal restrictive feeding behaviors have been associated with child weight status. The affective tone of mothers' statements intended to restrict their children's eating has not been examined. The objectives of this study were to describe the affective tone of mothers' restrictive feeding behaviors (positive or negative), and to test the association of child and mother characteristics with rates of Restriction with Positive Affect, Restriction with Negative Affect and Total Restriction. A total of 237 low-income child-mother dyads (mean child age 5.9 years) participated in a videotaped standardized laboratory eating protocol, during which mothers and children were both presented with large servings of cupcakes. A coding scheme was developed to count each restrictive statement with a positive affective tone and each restrictive statement with a negative affective tone. To establish reliability, 20% of videos were double-coded. Demographics and anthropometrics were obtained. Poisson regression models were used to test the association between characteristics of the child and mother with counts of Restriction with Positive Affect, Restriction with Negative Affect, and Total Restriction. Higher rates of Restriction with Positive Affect and Total Restriction were predicted by child obese weight status, and mother non-Hispanic white race/ethnicity. Higher rates of Restriction with Negative Affect were predicted by older child age, child obese weight status, mother non-Hispanic white race/ethnicity, and lower mother education level. In conclusion, in this study mothers of obese (vs. non-obese) children had higher rates of restriction in general, but particularly higher rates of Restriction with Negative Affect. Rather than being told not to restrict, mothers may need guidance on how to sensitively restrict their child's intake. Future studies should consider the contributions of maternal affect to children's responses to maternal restriction.

  13. The use of fractal tones in tinnitus patient management

    Directory of Open Access Journals (Sweden)

    Robert W Sweetow


    Full Text Available A variety of noises have been employed for decades in an effort to facilitate habituation, mask, or suppress tinnitus. Many of these sounds have reportedly provided benefit, but success has not been universal. More recently, musical stimuli have been added as a sound therapy component. The potential advantages of using such stimuli, in particular fractal tones, in combination with amplification are discussed in this paper.

  14. Categorical Perception of Lexical Tones in Mandarin-speaking Congenital Amusics

    Directory of Open Access Journals (Sweden)

    Wan Ting Huang


    Full Text Available Previous research suggests that within Mandarin-speaking congenital amusics, only a subgroup has behavioral lexical tone perception impairments (tone agnosia, whereas the rest of amusics do not. The purpose of the current study was to investigate the categorical nature of lexical tone perception in Mandarin-speaking amusics with and without behavioral lexical tone deficits. Three groups of listeners (controls, pure amusics and amusics with tone agnosia participated in tone identification and discrimination tasks. Indexes of the categorical perception of a physical continuum of fundamental frequencies ranging from a rising to level tone were measured. Specifically, the stimulus durations were manipulated at 100 and 200 ms. For both stimulus durations, all groups exhibited similar categorical boundaries. The pure amusics showed sharp identification slopes and significantly peaked discrimination functions similar to those of normal controls. However, such essential characteristics for the categorical perception of lexical tones were not observed in amusics with tone agnosia. An enlarged step-size from 20 Hz to 35 Hz was not able to produce any discrimination peaks in tone agnosics either. The current study revealed that only amusics with tone agnosia showed a lack of categorical tone perception, while the pure amusics demonstrated typical categorical perception of lexical tones, indicating that the deficit of pitch processing in music does not necessarily result in the deficit in the categorical perception of lexical tones. The different performance between congenital amusics with and without tone agnosia provides a new perspective on the proposition of the relationship between music and speech perception.

  15. Jazz Guitar Improvisation: Beginning with Guide-Tones

    Directory of Open Access Journals (Sweden)

    Daniel Andersen


    Full Text Available This article discusses an approach to teaching linear improvisation to beginning jazz guitarists through the function of voice leading in harmonic progressions. The student may gain a clear understanding of improvising melodies by establishing clear visual and aural relationships between the chordal and melodic textures. Three dominant 7th chord voicings are introduced and applied to a twelve bar blues progression in F major. After learning the rhythm guitar accompaniment, single note guide tones consisting of the flat 7th and 3rd chord tones of each dominant seventh chord are extracted from the chord voicings and applied in a melodic texture following chromatic voice leading principles within the harmonic progression. Musicality within the exercises is increased by the addition of a series of rhythmic variations that are applied to the guide-tone lines. Continuing with the concept, full dominant seventh arpeggios are introduced in order to expand the available note choices as a way to build a solid foundation for improvising within harmonic progressions prior to using diatonic scales.


    Directory of Open Access Journals (Sweden)

    Begum Aytemur


    Full Text Available This research investigated the effect of a five stage study program applied by the researcher to one student who had entered university playing the flute, but who had not resolved lip and tone problems in one educational semester through basic long sound studies and scale studies. The participant in the research was a 19 year old student who had completed first year of the music teaching program and had performed in the year-end concert; however she was criticized by listeners and flute teachers for forced and scratchy tone. The research had the basic aim of solving these problems. As a result the “single subject study model”, chosen for research on individuals requesting private training, was chosen for this research model. The findings of the study were collected as video recordings of scale, study and piece work in initial, training and final stages of a six-week education course run every day. To evaluate the obtained recordings, a “Behavior for Quality Flute Tone Scale” was created. The video recordings were investigated by three flute teaching staff, expert in the area, who provided points in accordance with the scale. The obtained points were analyzed using the SPSS 15.0 program. The results showed that the study program created by the researcher provided rapid tonal development of the student. It is considered that the study is important to present an alternative route for flute students experiencing similar problems.

  17. Purinergic control of vascular tone in the retina. (United States)

    Kur, Joanna; Newman, Eric A


    Purinergic control of vascular tone in the CNS has been largely unexplored. This study examines the contribution of endogenous extracellular ATP, acting on vascular smooth muscle cells, in controlling vascular tone in the in vivo rat retina. Retinal vessels were labelled by i.v. injection of a fluorescent dye and imaged with scanning laser confocal microscopy. The diameters of primary arterioles were monitored under control conditions and following intravitreal injection of pharmacological agents. Apyrase (500 units ml(-1)), an ATP hydrolysing enzyme, dilated retinal arterioles by 40.4 ± 2.8%, while AOPCP (12.5 mm), an ecto-5'-nucleotidase inhibitor that increases extracellular ATP levels, constricted arterioles by 58.0 ± 3.8% (P < 0.001 for both), demonstrating the importance of ATP in the control of basal vascular tone. Suramin (500 μm), a broad-spectrum P2 receptor antagonist, dilated retinal arterioles by 50.9 ± 3.7% (P < 0.001). IsoPPADS (300 μm) and TNP-ATP (50 μm), more selective P2X antagonists, dilated arterioles by 41.0 ± 5.3% and 55.2 ± 6.1% respectively (P < 0.001 for both). NF023 (50 μm), a potent antagonist of P2X1 receptors, dilated retinal arterioles by 32.1 ± 2.6% (P < 0.001). A438079 (500 μm) and AZ10606120 (50 μm), P2X7 antagonists, had no effect on basal vascular tone (P = 0.99 and P = 1.00 respectively). In the ex vivo retina, the P2X1 receptor agonist α,β-methylene ATP (300 nm) evoked sustained vasoconstrictions of 18.7 ± 3.2% (P < 0.05). In vivo vitreal injection of the gliotoxin fluorocitrate (150 μm) dilated retinal vessels by 52.3 ± 1.1% (P < 0.001) and inhibited the vasodilatory response to NF023 (50 μm, 7.9 ± 2.0%; P < 0.01). These findings suggest that vascular tone in rat retinal arterioles is maintained by tonic release of ATP from the retina. ATP acts on P2X1 receptors, although contributions from other P2X and P2Y receptors cannot be ruled out. Retinal glial cells are a possible source of the vasoconstricting ATP.

  18. Effects of Early Bilingual Experience with a Tone and a Non-Tone Language on Speech-Music Integration. (United States)

    Asaridou, Salomi S; Hagoort, Peter; McQueen, James M


    We investigated music and language processing in a group of early bilinguals who spoke a tone language and a non-tone language (Cantonese and Dutch). We assessed online speech-music processing interactions, that is, interactions that occur when speech and music are processed simultaneously in songs, with a speeded classification task. In this task, participants judged sung pseudowords either musically (based on the direction of the musical interval) or phonologically (based on the identity of the sung vowel). We also assessed longer-term effects of linguistic experience on musical ability, that is, the influence of extensive prior experience with language when processing music. These effects were assessed with a task in which participants had to learn to identify musical intervals and with four pitch-perception tasks. Our hypothesis was that due to their experience in two different languages using lexical versus intonational tone, the early Cantonese-Dutch bilinguals would outperform the Dutch control participants. In online processing, the Cantonese-Dutch bilinguals processed speech and music more holistically than controls. This effect seems to be driven by experience with a tone language, in which integration of segmental and pitch information is fundamental. Regarding longer-term effects of linguistic experience, we found no evidence for a bilingual advantage in either the music-interval learning task or the pitch-perception tasks. Together, these results suggest that being a Cantonese-Dutch bilingual does not have any measurable longer-term effects on pitch and music processing, but does have consequences for how speech and music are processed jointly.

  19. Effects of Early Bilingual Experience with a Tone and a Non-Tone Language on Speech-Music Integration.

    Directory of Open Access Journals (Sweden)

    Salomi S Asaridou

    Full Text Available We investigated music and language processing in a group of early bilinguals who spoke a tone language and a non-tone language (Cantonese and Dutch. We assessed online speech-music processing interactions, that is, interactions that occur when speech and music are processed simultaneously in songs, with a speeded classification task. In this task, participants judged sung pseudowords either musically (based on the direction of the musical interval or phonologically (based on the identity of the sung vowel. We also assessed longer-term effects of linguistic experience on musical ability, that is, the influence of extensive prior experience with language when processing music. These effects were assessed with a task in which participants had to learn to identify musical intervals and with four pitch-perception tasks. Our hypothesis was that due to their experience in two different languages using lexical versus intonational tone, the early Cantonese-Dutch bilinguals would outperform the Dutch control participants. In online processing, the Cantonese-Dutch bilinguals processed speech and music more holistically than controls. This effect seems to be driven by experience with a tone language, in which integration of segmental and pitch information is fundamental. Regarding longer-term effects of linguistic experience, we found no evidence for a bilingual advantage in either the music-interval learning task or the pitch-perception tasks. Together, these results suggest that being a Cantonese-Dutch bilingual does not have any measurable longer-term effects on pitch and music processing, but does have consequences for how speech and music are processed jointly.

  20. Effects of attention to and awareness of preceding context tones on auditory streaming. (United States)

    Weintraub, David M; Metzger, Brian A; Snyder, Joel S


    This study determined whether facilitation of auditory stream segregation could occur when facilitating context tones are accompanied by other sounds. Facilitation was measured as the likelihood of a repeated context tone that could match the low (A) or high (B) frequency of a repeating ABA test to increase the likelihood of hearing the test as segregated. We observed this type of facilitation when matching tones were alone, or with simultaneous bandpass noises or continuous speech, neither of which masked the tones. However, participants showed no streaming facilitation when a harmonic complex masked the context tones. Mistuning or desynchronizing the context tone relative to the rest of the complex did not facilitate streaming, despite the fact that the context tone was accessible to awareness and attention. Even presenting the context tone in a separate ear from the rest of the harmonic complex did not facilitate streaming, ruling out peripheral interference. Presenting the test as mistuned or desynchronized tones relative to complex tones eliminated the possibility that timbre changes from context to test interfered with facilitation resulting from the context. These results demonstrate the fragility of streaming facilitation and show that awareness of and attention to the context tones are not sufficient to overcome interference.

  1. A New View of Language Development: The Acquisition of Lexical Tone. (United States)

    Singh, Leher; Fu, Charlene S L


    Research in first language development draws disproportionately from nontone languages. Such research is often presumed to reveal developmental universals in spite of the fact that most languages are tone languages. Recent research in the acquisition of tone languages points to a distinct course of development as compared to nontone languages. Our purpose is to provide an integrated review of research on lexical tone acquisition. First, the linguistic properties and origins of tone languages are described. Following this, research on the acquisition of tones in perception and production is reviewed and integrated. Possible reasons for the uniqueness of tone in language acquisition are discussed. Finally, theoretical advances promised by further research on tone acquisition and specific research directions are proposed.

  2. The Enduring Significance of Skin Tone: Linking Skin Tone, Attitudes Toward Marriage and Cohabitation, and Sexual Behavior. (United States)

    Landor, Antoinette M; Halpern, Carolyn Tucker


    Past evidence has documented that attitudes toward marriage and cohabitation are related to sexual behavior in adolescence and young adulthood. This study extends prior research by longitudinally testing these associations across racial/ethnic groups and investigating whether culturally relevant variations within racial/ethnic minority groups, such as skin tone (i.e., lightness/darkness of skin color), are linked to attitudes toward marriage and cohabitation and sex. Drawing on family and public health literatures and theories, as well as burgeoning skin tone literature, it was hypothesized that more positive attitudes toward marriage and negative attitudes toward cohabitation would be associated with less risky sex, and that links differed for lighter and darker skin individuals. The sample included 6872 respondents (49.6 % female; 70.0 % White; 15.8 % African American; 3.3 % Asian; 10.9 % Hispanic) from the National Longitudinal Study of Adolescent to Adult Health. The results revealed that marital attitudes had a significantly stronger dampening effect on risky sexual behavior of lighter skin African Americans and Asians compared with their darker skin counterparts. Skin tone also directly predicted number of partners and concurrent partners among African American males and Asian females. We discuss theoretical and practical implications of these findings for adolescence and young adulthood.

  3. Peripheral arterial line (image) (United States)

    A peripheral arterial line is a small, short plastic catheter placed through the skin into an artery of the arm or leg. The purpose of a peripheral arterial line is to allow continuous monitoring of ...

  4. Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol. (United States)

    Neuman, Robert B; Hayek, Salim S; Poole, Joseph C; Rahman, Ayaz; Menon, Vivek; Kavtaradze, Nino; Polhemus, David; Veledar, Emir; Lefer, David J; Quyyumi, Arshed A


    Endothelial dysfunction is more prevalent in African Americans (AAs) compared with whites. The authors hypothesized that nebivolol, a selective β1 -antagonist that stimulates nitric oxide (NO), will improve endothelial function in AAs with hypertension when compared with metoprolol. In a double-blind, randomized, crossover study, 19 AA hypertensive patients were randomized to a 12-week treatment period with either nebivolol 10 mg or metoprolol succinate 100 mg daily. Forearm blood flow (FBF) was measured using plethysmography at rest and after intra-arterial infusion of acetylcholine and sodium nitroprusside to estimate endothelium-dependent and independent vasodilation, respectively. Physiologic vasodilation was assessed during hand-grip exercise. Measurements were repeated after NO blockade with L-N(G) -monomethylarginine (L-NMMA) and after inhibition of endothelium-derived hyperpolarizing factor (EDHF) with tetraethylammonium chloride (TEA). NO blockade with L-NMMA produced a trend toward greater vasoconstriction during nebivolol compared with metoprolol treatment (21% vs 12% reduction in FBF, P=.06, respectively). This difference was more significant after combined administration of L-NMMA and TEA (Pmetoprolol treatment. There were significantly greater contributions of NO and EDHF to resting vasodilator tone and of NO to exercise-induced vasodilation with nebivolol compared with metoprolol in AAs with hypertension.

  5. P2 receptors in the central and peripheral nervous systems modulating sympathetic vasomotor tone. (United States)

    Ralevic, V


    Arterial pressure depends on the level of activity of sympathetic vasoconstrictor outflow to blood vessels. This activity is generated in the central nervous system, and involves inputs from a variety of brain regions projecting to sympathetic preganglionic neurones. Of especial interest are a group of neurones in the rostral ventrolateral medulla (RVLM), as they have been demonstrated to have a fundamental role in reflex regulation of the cardiovascular system, and in generation of tonic drive to sympathetic outflow. Sympathetic outflow to blood vessels is additionally modulated at sympathetic ganglia, and at the peripheral terminals of sympathetic nerves. This review considers the role of P2 purine receptors in this neural pathway. Ionotropic P2X receptors are expressed in the RVLM, in sympathetic ganglia, and at the sympathetic neuromuscular junction, and mediate fast excitatory neurotransmission, indicating a general role for ATP as a regulator of sympathetic vasomotor tone. P2Y receptors couple to G proteins and mediate slower signalling to ATP; they have been reported to inhibit prejunctionally neurotransmission at the peripheral terminals of sympathetic nerves, but little is known about their possible role in the central nervous system and in sympathetic ganglia.

  6. Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia (United States)

    Glenny, R. W.; Robertson, H. T.; Hlastala, M. P.


    To determine whether vasoregulation is an important cause of pulmonary perfusion heterogeneity, we measured regional blood flow and gas exchange before and after giving prostacyclin (PGI(2)) to baboons. Four animals were anesthetized with ketamine and mechanically ventilated. Fluorescent microspheres were used to mark regional perfusion before and after PGI(2) infusion. The lungs were subsequently excised, dried inflated, and diced into approximately 2-cm(3) pieces (n = 1,208-1,629 per animal) with the spatial coordinates recorded for each piece. Blood flow to each piece was determined for each condition from the fluorescent signals. Blood flow heterogeneity did not change with PGI(2) infusion. Two other measures of spatial blood flow distribution, the fractal dimension and the spatial correlation, did not change with PGI(2) infusion. Alveolar-arterial O(2) differences did not change with PGI(2) infusion. We conclude that, in normal primate lungs during normoxia, vasomotor tone is not a significant cause of perfusion heterogeneity. Despite the heterogeneous distribution of blood flow, active regulation of regional perfusion is not required for efficient gas exchange.

  7. Modelisations des effets de surface sur les jets horizontaux subsoniques d'hydrogene et de methane (United States)

    Gomez, Luis Fernando

    Le developpement des codes et de normes bases sur une methodologie scientifique requiert la capacite de predire l'etendue inflammable de deversements gazeux d'hydrogene sous differentes conditions. Des etudes anterieures ont deja etabli des modeles bases sur les lois de conservation de la mecanique des fluides basees sur des correlations experimentales qui permettent de predire la decroissance de la concentration et de la vitesse d'un gaz le long de l'axe d'un jet libre vertical. Cette etude s'interesse aux effets de proximite a une surface horizontale parallele sur un jet turbulent. Nous nous interessons a son impact sur l'etendue du champ de la concentration et sur l'enveloppe inflammable en particulier. Cette etude est comparative : l'hydrogene est compare au methane. Ceci permet de degager l'influence des effets de difference de la densite sur le comportement du jet, et de comparer le comportement de l'hydrogene aux correlations experimentales, qui ont ete essentiellement etablies pour le methane. Un modele decrivant l'evolution spatio-temporelle du champ de concentration du gaz dilue est propose, base sur la mecanique des fluides computationnelle. Cette approche permet de varier systematiquement les conditions aux frontieres (proximite du jet a la surface, par exemple) et de connaitre en detail les proprietes de l'ecoulement. Le modele est implemente dans le code de simulations par volumes finis de FLUENT. Les resultats des simulations sont compares avec les lois de similitudes decoulant de la theorie des jets d'ecoulements turbulents libres ainsi qu'avec les resultats experimentaux disponibles. L'effet de la difference des masses molaires des constituantes du jet et des constituantes du milieu de dispersion est egalement etudie dans le contexte du comportement d'echelle de la region developpee du jet.

  8. Vascular tone and reactivity to serotonin in the internal and external carotid vascular beds of the dog. (United States)

    Vidrio, H; Hong, E


    The effects of intra-arterial infusions of serotonin on internal and external carotid blood flow were determined in anesthetized dogs by electromagnetic flow measurements. Serotonin decreased flow in the internal carotid and increased it in the external carotid. Both responses were blocked by the serotonin antagonist methysergide. The alpha adrenergic antagonist zolertine, the ganglionic blocking agent chlorisondamine and the vasodilator diazoxide blocked external carotid dilator responses but did not modify constriction in the internal carotid. Blockade of external carotid responses by the three drugs was also demonstrated in experiments in which this bed was perfused at a constant rate. These results indicate that the internal and external carotid vascular beds of the dog react in opposite ways to serotonin, that both responses are mediated through the same type of serotonin receptors and that the dilator responses of the external carotid are dependent on vascular tone.

  9. Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries. (United States)

    Kun, Attila; Seprényi, György; Varró, András; Papp, Julius Gy; Pataricza, János


    The purpose of this study was to investigate the vasoactivity of two inhibitors of potassium ion (K(+) ) channels, a potential antiarrhythmic compound, AVE 0118, and 4-aminopyridine (4-AP). Basal and stimulated tones of rat small mesenteric arteries as well as the possible involvement of KV 1.5 ion channel in the mechanism of vascular effect induced by the compounds were analysed. The standard organ bath technique for vascular tone and immunohistochemistry for the localization of ion channels in the arterial tissue were performed. Third- or fourth-order branch of arterial segments was mounted in myographs for recording the isometric tension. AVE 0118 (10(-5) M) and 4-AP (10(-5) M) modulated neither the basal tone nor the contraction induced by noradrenaline but increased the contraction evoked by electrical field stimulation, sensitive to the block of alpha-1 adrenergic receptors. KV 1.5 ion channel-specific immunostaining demonstrated the presence of immunoreactive nerves, and Schwann-cell-specific (S100) immunostaining confirmed the presence of myelin sheath in rat small mesenteric arteries. The study supports an indirect, sympathetic effect of AVE 0118 similar to that of 4-AP, which is mediated, at least in part, by blocking neuronal KV 1.5 type potassium ion channels in the medio-adventitial layer of rat small mesenteric artery.

  10. Le potentiel d’atténuation des gaz à effet de serre en productions bovines


    Agabriel, Jacques; Dollé, J.-B.; Faverdin, Philippe; VAN DER WERF, Hayo


    L’élevage bovin est l’un des principaux contributeurs aux émissions de gaz à effet de serre (GES), le principal poste étant la fermentation entérique. En contrepartie, le stockage de carbone par les prairies et les haies compense de 25 à 30% des émissions nationales. L’élevage est également la phase qui domine l’empreinte carbone des produits lait et viande. L’analyse à l’échelle des exploitations fait apparaître une grande variabilité des niveaux d’émissions et de compensation et permet l’id...

  11. Arterial Myogenic Activation through Smooth Muscle Filamin A

    Directory of Open Access Journals (Sweden)

    Kevin Retailleau


    Full Text Available Mutations in the filamin A (FlnA gene are frequently associated with severe arterial abnormalities, although the physiological role for this cytoskeletal element remains poorly understood in vascular cells. We used a conditional mouse model to selectively delete FlnA in smooth muscle (sm cells at the adult stage, thus avoiding the developmental effects of the knockout. Basal blood pressure was significantly reduced in conscious smFlnA knockout mice. Remarkably, pressure-dependent tone of the resistance caudal artery was lost, whereas reactivity to vasoconstrictors was preserved. Impairment of the myogenic behavior was correlated with a lack of calcium influx in arterial myocytes upon an increase in intraluminal pressure. Notably, the stretch activation of CaV1.2 was blunted in the absence of smFlnA. In conclusion, FlnA is a critical upstream element of the signaling cascade underlying the myogenic tone. These findings allow a better understanding of the molecular basis of arterial autoregulation and associated disease states.

  12. Online processing of tone and intonation in Mandarin: Evidence from ERPs. (United States)

    Liu, Min; Chen, Yiya; Schiller, Niels O


    Event-related potentials (ERPs) were used to investigate the online processing of tone and intonation in Mandarin at the attentive stage. We examined the behavioral and electrophysiological responses of native Mandarin listeners to Mandarin sentences, which contrast in final tones (rising Tone2 or falling Tone4) and intonations (Question or Statement). A clear P300 effect was observed for question-statement contrast in sentences ending with Tone4, but no ERP effect was found for question-statement contrast in sentences ending with Tone2. Our results provide ERP evidence for the interaction of tone and intonation in Mandarin, confirming the findings with behavioral metalinguistic data that native Mandarin listeners can distinguish between question intonation and statement intonation when the intonation is associated with a final Tone4, but fail to do so when the intonation is associated with a final Tone2. Our study extended the understanding of online processing of tone and intonation (1) from the pre-attentive stage to the attentive stage and (2) within a larger domain (i.e. multi-word utterances) than a single word utterance.

  13. Cantonese tone production performance of mainstream school children with hearing impairment. (United States)

    Cheung, Karen K L; Lau, Ada H Y; Lam, Joffee H S; Lee, Kathy Y S


    This study investigated the Cantonese tone production ability of children with hearing impairment studying in mainstream schools. The participants were 87 Cantonese-speaking children with mild-to-profound degrees of hearing loss aged 5.92-13.58 in Hong Kong. Most of the children were fitted with hearing aids (n = 65); 17 of them had profound hearing impairment, one who had severe hearing loss had cochlear implantation, and four who had mild hearing loss were without any hearing device. The Hong Kong Cantonese Articulation Test was administered, and the tones produced were rated by two of the authors and a speech-language pathologist. Group effects of tones, hearing loss level, and also an interaction of the two were found to be significant. The children with profound hearing impairment performed significantly worse than most of the other children. Tone 1 was produced most accurately, whereas tone 6 productions were the poorest. No relationship was found between the number of years of mainstreaming and tone production ability. Tone production error pattern revealed that confusion patterns in tone perception coincided with those in production. Tones having a similar fundamental frequency (F0) at the onset also posed difficulty in tone production for children with hearing impairment.

  14. An Isoperimetric Inequality for Fundamental Tones of Free Plates

    CERN Document Server

    Chasman, L M


    We establish an isoperimetric inequality for the fundamental tone (first nonzero eigenvalue) of the free plate of a given area, proving the ball is maximal. Given $\\tau>0$, the free plate eigenvalues $\\omega$ and eigenfunctions $u$ are determined by the equation $\\Delta\\Delta u-\\tau\\Delta u = \\omega u$ together with certain natural boundary conditions. The boundary conditions are complicated but arise naturally from the plate Rayleigh quotient, which contains a Hessian squared term $|D^2u|^2$. We adapt Weinberger's method from the corresponding free membrane problem, taking the fundamental modes of the unit ball as trial functions. These solutions are a linear combination of Bessel and modified Bessel functions.

  15. An isoperimetric inequality for the fundamental tone of free plates

    CERN Document Server

    Chasman, L M


    We establish an isoperimetric inequality for the fundamental tone (first nonzero eigenvalue) of the free plate of a given area, proving the ball is maximal. Given $\\tau>0$, the free plate eigenvalues $\\omega$ and eigenfunctions $u$ are determined by the equation $\\Delta\\Delta u-\\tau\\Delta u = \\omega u$ together with certain natural boundary conditions. The boundary conditions are complicated but arise naturally from the plate Rayleigh quotient, which contains a Hessian squared term $|D^2u|^2$. We adapt Weinberger's method from the corresponding free membrane problem, taking the fundamental modes of the unit ball as trial functions. These solutions are a linear combination of Bessel and modified Bessel functions.

  16. Arm Robot Surveillance Using Dual Tone Multiple Frequency Technology

    Directory of Open Access Journals (Sweden)



    Full Text Available Surveillance place a pivotal role in addressing a wide range of security challenges .In the present paper we propose a Dual Tone Multiple Frequency ( DTMF based Robot with video surveillance. In the proposed model a DTMF based Robot with video surveillance with multiple key functions, Arm picker and security system was implemented. Master and slave concept using 3 Microcontroller and motor driver IC to drive motors was implemented and belt wheel platform was used to move the robot from one place to another. Multiple key functions were used to perform more functions and a camera for surveillance .The robot can navigate with the help of the user.

  17. La réponse graduée de l’Hadopi a-t-elle un effet sur le piratage de musique et de films ? Une étude empirique des pratiques de consommation en ligne


    Éric Darmon; Sylvain Dejean; Thierry Pénard


    L’objet de cette étude est d’évaluer les effets de l’Hadopi (Haute Autorité pour la Diffusion des OEuvres et la protection des droits sur Internet) sur les pratiques de consommation d’oeuvres musicales et audiovisuelles. L’Hadopi peut avoir potentiellement trois types d’effets : des effets informationnels (par un travail de sensibilisation et de pédagogie auprès des internautes), des effets dissuasifs (à travers la surveillance des réseaux de partage et l’envoi d’avertissements) et des effets...

  18. Comparaison des effets des irradiations γ, X et UV dans les fibres optiques (United States)

    Girard, S.; Ouerdane, Y.; Baggio, J.; Boukenter, A.; Meunier, J.-P.; Leray, J.-L.


    Les fibres optiques présentent de nombreux avantages incitant à les intégrer dans des applications devant résister aux environnements radiatifs associés aux domaines civil, spatial ou militaire. Cependant, leur exposition à un rayonnement entraîne la création de défauts ponctuels dans la silice amorphe pure ou dopée qui constitue les différentes parties de la fibre optique. Ces défauts causent, en particulier, une augmentation transitoire de l'atténuation linéique des fibres optiques responsable de la dégradation voire de la perte du signal propagé dans celles-ci. Dans cet article, nous comparons les effets de deux types d'irradiation: une impulsion X et une dose γ cumulée. Les effets de ces irradiations sont ensuite comparés avec ceux induits par une insolation ultraviolette (244 nm) sur les propriétés d'absorption des fibres optiques. Nous montrons qu'il existe des similitudes entre ces différentes excitations et qu'il est possible, sous certaines conditions, d'utiliser celles-ci afin d'évaluer la capacité de certaines fibres optiques à fonctionner dans un environnement nucléaire donné.

  19. covert contrast: The acquisition of Mandarin tone 2 and tone 3 in L2 production and perception (United States)

    Mar, Li-Ya

    This dissertation investigates the occurrence of an intermediate stage, termed a covert contrast, in the acquisition of Mandarin Tone 2 (T2) and Tone 3 (T3) by adult speakers of American English. A covert contrast is a statistically reliable distinction produced by language learners that is not perceived by native speakers of the target language (TL). In second language (L2) acquisition, whether a learner is judged as having acquired a TL phonemic contrast has largely depended on whether the contrast was perceived and transcribed by native speakers of the TL. However, categorical perception has shown that native listeners cannot perceive a distinction between two sounds that fall within the same perceptual boundaries on the continuum of the relevant acoustic cues. In other words, it is possible that native speakers of the TL do not perceive a phonemic distinction that is produced by L2 learners when that distinction occurs within a phonemic boundary of TL. The data for the study were gathered through two elicitations of tone production, a longitudinal analysis, and two perception tasks. There were three key findings. First, both elicitations showed that most of the L2 participants produced a covert contrast between T2 and T3 on at least one of the three acoustic measures used in the study. Second, the longitudinal analysis reveals that some L2 participants progressed from making a covert contrast to a later stage of implementing an overt one, thereby supporting the claim that making a covert contrast is an intermediate stage in the process of acquiring a L2 phonemic contrast. Third, results of the perceptual tasks showed no reliable difference in identifying and discriminating Mandarin T2 and T3 on the part of the L2 learners who produced a covert contrast and those who produced an overt contrast, indicating that there was no reliable difference in the two groups' ability to perceive the target tones. In all, the occurrence of a covert contrast in the process of

  20. Vagal tone during quiet sleep in normal human term fetuses. (United States)

    Groome, L J; Mooney, D M; Bentz, L S; Wilson, J D


    The purpose of this paper was to calculate vagal tone (V) for 17 normal human fetuses in quiet sleep (QS) between 36 and 40 weeks gestation. The fetal cardiac electrical signal was captured transabdominally in 3-min blocks at a rate of 833 times per second and fetal R-waves were extracted using adaptive signal processing techniques. Fetal R-wave interbeat intervals were converted to equally spaced, time-based data, and the low-frequency component was removed using a 21-point third-order moving polynomial. The parameter V was calculated by taking the natural logarithm of the sum of the power densities between 0.3 Hz and 1.3 Hz. We found that fetal breathing was associated with an approximately 25% increase in V as compared to nonbreathing, 3.33 +/- 0.48 versus 2.57 +/- 0.47, p < 0.0001. Furthermore, there was a significant linear relationship between the mean single-fetus V during spontaneous respiration and the mean single-fetus V during normally occurring apneic periods, r = 0.772, p < 0.002. We conclude that respiratory activity is associated with a significant increase in vagal tone for normal human fetuses in QS.

  1. The effect of kisspeptin on the regulation of vascular tone. (United States)

    Mezei, Zsófia; Zamani-Forooshani, Omid; Csabafi, Krisztina; Szikszai, Bence; Papp, Eszter; Ónodi, Ádám; Török, Dóra; Leprán, Ádám; Telegdy, Gyula; Szabó, Gyula


    Kisspeptin has been implicated in cardiovascular control. Eicosanoids play a crucial role in the activation of platelets and the regulation of vascular tone. In the present study, we investigated the effect of kisspeptins on eicosanoid synthesis in platelets and aorta in vitro. Platelets and aorta were isolated from Wistar-Kyoto rats. After preincubation with different doses of kisspeptin, samples were incubated with [1-(14)C]arachidonic acid (0.172 pmol/mL) in tissue culture Medium 199. The amount of labeled eicosanoids was measured with liquid scintillation, after separation with overpressure thin-layer chromatography. Kisspeptin-13 stimulated the thromboxane synthesis. The dose-response curve was bell-shaped and the most effective concentration was 2.5 × 10(-8) mol/L, inducing a 27% increase. Lipoxygenase products of platelets displayed a dose-dependent elevation up to the dose of 5 × 10(-8) mol/L. In the aorta, kisspeptin-13 induced a marked elevation in the production of 6-keto-prostaglandin F1α, the stable metabolite of prostacyclin, and lipoxygenase products. Different effects of kisspeptin on cyclooxygenase and lipoxygenase products indicate that beyond intracellular Ca(2+) mobilization, other signaling pathways might also contribute to its actions. Our data suggest that kisspeptin, through the alteration of eicosanoid synthesis in platelets and aorta, may play a physiologic and (or) pathologic role in the regulation of vascular tone.

  2. Predicting the decay time of solid body electric guitar tones. (United States)

    Paté, Arthur; Le Carrou, Jean-Loïc; Fabre, Benoît


    Although it can be transformed by various electronic devices, the sound of the solid body electric guitar originates from, and is strongly linked with, the string vibration. The coupling of the string with the guitar alters its vibration and can lead to decay time inhomogeneities. This paper implements and justifies a framework for the study of decay times of electric guitar tones. Two damping mechanisms are theoretically and experimentally identified: the string intrinsic damping and the damping due to mechanical coupling with the neck of the guitar. The electromagnetic pickup is shown to not provide any additional damping to the string. The pickup is also shown to be far more sensitive to the out-of-plane polarization of the string. Finally, an accurate prediction of the decay time of electric guitar tones is made possible, whose only requirements are the knowledge of the isolated string dampings and the out-of-plane conductance at the neck of the guitar. This prediction can be of great help for instrument makers and manufacturers.

  3. Systemes Fermioniques a Basse Dimension D'espace: Supraconductivite, Effet Hall Quantique et Statistique Fractionnaire (United States)

    Sakhi, Said

    Cette these est constituee de trois sujets de recherche distincts. Les deux premiers articles traitent du phenomene de supraconductivite dans un modele bidimensionnel, dans le troisieme article on etudie l'action effective d'un systeme electronique soumis a l'effet d'un champ magnetique (systeme de Hall) et le dernier article examine la quantification d'un systeme de particules identiques en deux dimensions d'espace et la possibilite des anyons. Le modele qu'on analyse dans les deux premiers articles est un systeme fermionique dont les particules chargees et de masse nulle interagissent entre elles avcc un couplage attractif et fort. L'analyse de l'action effective decrivant la physique a basse energie nous permet d'examiner la structure de l'espace de phase. A temperature nulle, le parametre d'ordre du systeme prend une valeur moyenne non nulle. Consequemment, la symetrie continue U(1) du modele est spontanement brisee et il en resulte l'apparition d'un mode de Goldstone. En presence d'un champ electromagnetique externe, ce mode disparait et le champ de jauge acquiert une masse donc l'effet Meissner caracteristique d'un supraconducteur. Bien que le modele ne soit pas renormalisable dans le sens perturbatif, on montre qu'il l'est dans le cadre du developpement en 1/N ou N est le nombre d'especes fermioniques. En outre, on montre que l'inclusion des effets thermiques change radicalement le mecanisme de supraconductivite. En effet, on montre que la brisure spontanee de la symetrie U(1) n'est plus possible a temperature finie a cause de tres severes divergences infrarouges. Par contre, la dynamique des tourbillons (vortex) existant dans le plan devient essentielle. On montre que le phenomene de supraconductivite resulte du confinement de ces objets topologiques et que la temperature critique s'identifie a celle de Kosterlitz -Thouless. Ce mecanisme de supraconductivite presente l'avantage d'aboutir a un rapport gap a la temperature critique plus eleve que celui du

  4. Hardware Implementation of an Automatic Rendering Tone Mapping Algorithm for a Wide Dynamic Range Display



    Tone mapping algorithms are used to adapt captured wide dynamic range (WDR) scenes to the limited dynamic range of available display devices. Although there are several tone mapping algorithms available, most of them require manual tuning of their rendering parameters. In addition, the high complexities of some of these algorithms make it difficult to implement efficient real-time hardware systems. In this work, a real-time hardware implementation of an exponent-based tone mapping algorithm i...

  5. 17 Ways to Say Yes: Toward Nuanced Tone of Voice in AAC and Speech Technology


    Pullin, Graham; Hennig, Shannon


    Abstract People with complex communication needs who use speech-generating devices have very little expressive control over their tone of voice. Despite its importance in human interaction, the issue of tone of voice remains all but absent from AAC research and development however. In this paper, we describe three interdisciplinary projects, past, present and future: The critical design collection Six Speaking Chairs has provoked deeper discussion and inspired a social model of tone of voice;...

  6. Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.


    Double, K L; Crocker, A D


    The aim of the present study was to localize the dopamine receptors involved in the regulation of muscle tone. A strategy was used whereby the effects on muscle tone of injecting the irreversible dopamine receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) in discrete brain regions were assessed. Increases in muscle tone were measured as changes in electromyographic activity of the gastrocnemius and tibialis muscles of conscious, unrestrained rats. No increases in muscle...

  7. Improvement of Tone Intelligibility for Average-Voice-Based Thai Speech Synthesis


    Suphattharachai Chomphan; Chutarat Chompunth


    Problem statement: Tone intelligibility in speech synthesis is an important attribute that should be taken into account. The tone correctness of the synthetic speech is degraded considerably in the average-voice-based HMM-based Thai speech synthesis. The tying mechanism in the decision tree based context clustering without appropriate criterion causes unexpected tone neutralization. Incorporation of the phrase intonation to the context clustering process in the training stage was proposed ear...

  8. A study of laryngeal gestures in Mandarin citation tones using simultaneous laryngoscopy and laryngeal ultrasound (SLLUS)


    Moisik, S.; Lin, H.; Esling, J.


    In this work, Mandarin tone production is examined using simultaneous laryngoscopy and laryngeal ultrasound (SLLUS). Laryngoscopy is used to obtain information about laryngeal state, and laryngeal ultrasound is used to quantify changes in larynx height. With this methodology, several observations are made concerning the production of Mandarin tone in citation form. Two production strategies are attested for low tone production: (i) larynx lowering and (ii) larynx raising with laryngeal constr...

  9. Influences of vowel and tone variation on emergent word knowledge: a cross-linguistic investigation. (United States)

    Singh, Leher; Hui, Tam Jun; Chan, Calista; Golinkoff, Roberta Michnick


    To learn words, infants must be sensitive to native phonological contrast. While lexical tone predominates as a source of phonemic contrast in human languages, there has been little investigation of the influences of lexical tone on word learning. The present study investigates infants' sensitivity to tone mispronunciations in two groups of infants. For one group (Chinese learners), tone is phonemic in their native language, and for the second group (English learners), tone is non-phonemic and constituted suprasegmental variation. In Experiment 1, English learners were trained on novel word-object pairings and tested on their recognition of correct pronunciations, tone and vowel mispronunciations of these words at 18 and 24 months. In Experiment 2a, bilingual English-Chinese learners were tested on a similar task translated into Chinese at the same age intervals. Results demonstrate that non-tonal learners treated tonal and vowel substitutions alike as mispronunciations at 18 months but only treated vowel substitutions as mispronunciations at 24 months. Tonal learners treated both tonal and vowel substitutions as mispronunciations at both ages. In Experiment 2b, bilingual non-tone language learners were tested on the same set of tasks replicating a similar set of results as monolingual non-tone language learners (Experiment 1). Findings point to an early predisposition to treat tone as a defining characteristic of words regardless of its lexical relevance at 18 months. Between 18 and 24 months, learners appear to ascribe lexical relevance to tone in a language-specific manner. The current study identifies the influences of tone variation on memories for newly learned words and the time period during which lexical tone - a highly frequent constituent of human languages - actually becomes lexical for early learners. Findings are contextualized with prevailing models of the developing lexicon.

  10. On the design of tone-free ΣΔ modulators

    DEFF Research Database (Denmark)

    Risbo, Lars


    Traditional one-bit ΣΔ modulators used for A/D and D/A conversion produce very predominant tones near half the sample rate which might intermodulate in the analog converter section and cause in-band tones. This paper demonstrates how the use of chaos can substitute dither as a means for extinguis......Traditional one-bit ΣΔ modulators used for A/D and D/A conversion produce very predominant tones near half the sample rate which might intermodulate in the analog converter section and cause in-band tones. This paper demonstrates how the use of chaos can substitute dither as a means...

  11. Improvement of Tone Intelligibility for Average-Voice-Based Thai Speech Synthesis

    Directory of Open Access Journals (Sweden)

    Suphattharachai Chomphan


    Full Text Available Problem statement: Tone intelligibility in speech synthesis is an important attribute that should be taken into account. The tone correctness of the synthetic speech is degraded considerably in the average-voice-based HMM-based Thai speech synthesis. The tying mechanism in the decision tree based context clustering without appropriate criterion causes unexpected tone neutralization. Incorporation of the phrase intonation to the context clustering process in the training stage was proposed early. However, the tone correctness is not satisfied. Approach: This study proposes a number of tonal features including tone-geometrical features and phrase intonation features to be exploited in the context clustering process of HMM training stage. Results: In the experiments, subjective evaluations of both average voice and adapted voice in terms of the intelligibility of tone are conducted. Effects on decision trees of the extracted features are also evaluated. By considering gender in training speech, two core experiments were conducted. The first experiment shows that the proposed tonal features can improve the tone intelligibility for female speech model above that of male speech model, while the second experiment shows that the proposed tonal features improve the tone intelligibility for gender dependent model than for gender independent model. Conclusion: All of the experimental results confirm that the tone correctness of the synthesized speech from the average-voice-based HMM-based Thai speech synthesis is significantly improved when using most of the extracted features.

  12. Preattentive processing of emotional musical tones: a multidimensional scaling and ERP study

    Directory of Open Access Journals (Sweden)

    Thomas F Münte


    Full Text Available Musical emotion can be conveyed by subtle variations in timbre. Here, we investigated whether the brain is capable to discriminate tones differing in emotional expression by recording event-related potentials (ERPs in an oddball paradigm under preattentive listening conditions. First, using multidimensional Fechnerian scaling, pairs of violin tones played with a happy or sad intonation were rated same or different by a group of non-musicians. Three happy and three sad tones were selected for the ERP experiment. The Fechnerian distances between tones within an emotion were in the same range as the distances between tones of different emotions. In two conditions, either 3 happy and 1 sad or 3 sad and 1 happy tone were presented in pseudo-random order. A mismatch negativity for the emotional deviant was observed, indicating that in spite of considerable perceptual differences between the three equiprobable tones of the standard emotion, a template was formed based on timbral cues against which the emotional deviant was compared. Based on Juslin’s assumption of redundant code usage, we propose that tones were grouped together, because they were identified as belonging to one emotional category based on different emotion-specific cues. These results indicate that the brain forms an emotional memory trace at a preattentive level and thus extends previous investigations in which emotional deviance was confounded with physical dissimilarity. Differences between sad and happy tones were observed which might be due to the fact that the happy emotion is mostly communicated by suprasegmental features.

  13. Preattentive processing of emotional musical tones: a multidimensional scaling and ERP study. (United States)

    Spreckelmeyer, Katja N; Altenmüller, Eckart; Colonius, Hans; Münte, Thomas F


    Musical emotion can be conveyed by subtle variations in timbre. Here, we investigated whether the brain is capable to discriminate tones differing in emotional expression by recording event-related potentials (ERPs) in an oddball paradigm under preattentive listening conditions. First, using multidimensional Fechnerian scaling, pairs of violin tones played with a happy or sad intonation were rated same or different by a group of non-musicians. Three happy and three sad tones were selected for the ERP experiment. The Fechnerian distances between tones within an emotion were in the same range as the distances between tones of different emotions. In two conditions, either 3 happy and 1 sad or 3 sad and 1 happy tone were presented in pseudo-random order. A mismatch negativity for the emotional deviant was observed, indicating that in spite of considerable perceptual differences between the three equiprobable tones of the standard emotion, a template was formed based on timbral cues against which the emotional deviant was compared. Based on Juslin's assumption of redundant code usage, we propose that tones were grouped together, because they were identified as belonging to one emotional category based on different emotion-specific cues. These results indicate that the brain forms an emotional memory trace at a preattentive level and thus, extends previous investigations in which emotional deviance was confounded with physical dissimilarity. Differences between sad and happy tones were observed which might be due to the fact that the happy emotion is mostly communicated by suprasegmental features.

  14. Acquisition of Mandarin Lexical Tones:The Effect of Global Pitch T endency

    Institute of Scientific and Technical Information of China (English)



    This paper discusses the acquisition of Mandarin lexical tones by American second language ( L2 ) learners . The analysis of the tone errors in the reading passage and the spontaneous speech showed that the surface Tone 4 error is the most frequent at the prosodic word ( PW )‐initial position in both the intermediate and the advanced learner groups . Attempts were made to account for this tone error pattern within some second language acquisition (SLA) frameworks , but in vain . It was argued that this tone error pattern may be due to the high pitch tendency at the phrase‐or sentence‐initial position in speech . Although this is more of a general pattern across languages , the production of such a tendency by L2 learners superseded the underlying tones , hence the surface Tone 4 errors . The special status of Tone 4 in L2 speech corresponds to the special status of the same tone in the first language (L1 ) speech (Wan , 2007 ) . However , it was cautioned that such similarity should not be taken as evidence for the similarity in L1 and L2 acquisition in that different processes are involved in L1 and L2 production .


    Directory of Open Access Journals (Sweden)



    Full Text Available L’effet des vitamines B12, B9 et B6 sur la fragilité osmotique des érythrocytes humains a été exploré in vitro. De fortes concentrations de vitamines B12 et B6 ont protégé les érythrocytes de l’hémolyse hypotonique, avec une protection maxima atteinte respectivement à 10 et 500 µg/ml. A concentrations plus faibles, cependant, ces vitamines ont favorisé grandement l’hémolyse hypotonique. Par contre, la vitamine B9 a montré uniquement un effet hémolytique de 4 à 200 µg/ml. Cet effet peut être expliqué par la nature acide de la molécule. L’effet nul sur la fragilité osmotique de deux vitamines antagonistes, peut probablement être expliqué par l’antagonisme partiel ou par la présence de ces deux vitamines simultanément: ces dernières se lient en quantités appréciables à la cellule intacte de même qu’à l’hémolysat et il y’ a compétition mutuelle entre ces vitamines et leur transport.

  16. Effect of tone mapping operators on visual attention deployment (United States)

    Narwaria, Manish; Perreira Da Silva, Matthieu; Le Callet, Patrick; Pepion, Romuald


    High Dynamic Range (HDR) images/videos require the use of a tone mapping operator (TMO) when visualized on Low Dynamic Range (LDR) displays. From an artistic intention point of view, TMOs are not necessarily transparent and might induce different behavior to view the content. In this paper, we investigate and quantify how TMOs modify visual attention (VA). To that end both objective and subjective tests in the form of eye-tracking experiments have been conducted on several still image content that have been processed by 11 different TMOs. Our studies confirm that TMOs can indeed modify human attention and fixation behavior significantly. Therefore our studies suggest that VA needs consideration for evaluating the overall perceptual impact of TMOs on HDR content. Since the existing studies so far have only considered the quality or aesthetic appeal angle, this study brings in a new perspective regarding the importance of VA in HDR content processing for visualization on LDR displays.

  17. Thalamocortical mechanisms for integrating musical tone and rhythm. (United States)

    Musacchia, Gabriella; Large, Edward W; Schroeder, Charles E


    Studies over several decades have identified many of the neuronal substrates of music perception by pursuing pitch and rhythm perception separately. Here, we address the question of how these mechanisms interact, starting with the observation that the peripheral pathways of the so-called "Core" and "Matrix" thalamocortical system provide the anatomical bases for tone and rhythm channels. We then examine the hypothesis that these specialized inputs integrate acoustic content within rhythm context in auditory cortex using classical types of "driving" and "modulatory" mechanisms. This hypothesis provides a framework for deriving testable predictions about the early stages of music processing. Furthermore, because thalamocortical circuits are shared by speech and music processing, such a model provides concrete implications for how music experience contributes to the development of robust speech encoding mechanisms.

  18. A multi-modal approach to perceptual tone mapping

    Directory of Open Access Journals (Sweden)

    Vicent Caselles


    Full Text Available We present an improvement of TSTM, a recently proposed tone mapping operator for High Dynamic Range (HDR images, based on a multi-modal analysis. One of the key features of TSTM is a suitable implementation of the Naka-Rushton equation that mimics the visual adaptation performed by the human visual system coherently with Weber-Fechner's law of contrast perception. In the present paper we use the Gaussian Mixture Model (GMM in order to detect the modes of the log-scale luminance histogram of a given HDR image and then we use the information provided by GMM to properly devise a Naka-Rushton equation for each mode. Finally, we properly select the parameters in order to merge those equations into a continuous function. Tests and comparisons to show how this new method is capable of improving the performances of TSTM are provided and commented, as well as comparisons with state of the art methods.

  19. Responsiveness of muscle tone characteristics to progressive force production. (United States)

    Mustalampi, Sirpa; Häkkinen, Arja; Kautiainen, Hannu; Weir, Adam; Ylinen, Jari


    It is possible to measure muscle tone reliably, quickly and objectively using tonometers although they are not yet widely used. In clinical practice, it may be helpful if clinicians could assess the degree of contraction in different parts of a muscle without having to perform time-consuming electromyography measurements. The purpose of this study was to evaluate the responsiveness of different muscle tone characteristics to progressively increased contraction force of quadriceps muscle. Twenty healthy subjects (mean age 39.9 years, 50% women) volunteered. Using 2 different tonometers various muscle viscoelastic properties were measured. The frequency (hertz), logarithmic decrement, and stiffness (newtons per meter) of damped mechanical oscillation of the muscle tissue and tissue compliance (millijoules) were registered from rectus femoris muscle at rest and 20, 40, 60, 80% of maximal voluntary contraction determined using dynamometry. All the values changed linearly with increasing force level. Compliance, oscillation stiffness, and frequency parameters showed large effect sizes (ESs ≥ 0.8). The standardized respoknse mean for compliance was 5.3 (4.8-5.7) mJ, for oscillation stiffness 1.8 (1.3-2.2) N·m(-1), frequency 1.1 (0.6-1.5) Hz, and decrement -0.6 (-1.0 to -0.2). The results indicate that the compliance and oscillation stiffness parameters showed the highest responsiveness and can thus best detect changes in muscle contraction state. The additional value of using tonometers to measure these properties in clinical practice should be investigated further.

  20. [Anaesthesia and vasomotor tone during CPB: intravenous anaesthetics]. (United States)

    Durand, M


    Anaesthesia during CBP is frequently provided using intravenous anaesthetic drugs, particularly propofol. The effects of the different drugs have been studied during CPB. These drugs have an arterial and venous vasodilator effect during CPB which is dose dependent and is more pronounced for propofol. High doses of propofol or thiopental reduce cerebral blood flow but provide no additional neurological protection.

  1. Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

    Directory of Open Access Journals (Sweden)

    Karl Swärd

    Full Text Available Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae. Mice with caveolin-1 deficiency have dysfunctional blood vessels, but whether absence of cavin-1 similarly leads to vascular dysfunction is not known. Here we addressed this hypothesis using small mesenteric arteries from cavin-1-deficient mice. Cavin-1-reporter staining was intense in mesenteric arteries, brain arterioles and elsewhere in the vascular system, with positive staining of both endothelial and smooth muscle cells. Arterial expression of cavin-1, -2 and -3 was reduced in knockout (KO arteries as was expression of caveolin-1, -2 and -3. Caveolae were absent in the endothelial and smooth muscle layers of small mesenteric arteries as determined by electron microscopy. Arginase, a negative regulator of nitric oxide production, was elevated in cavin-1 deficient arteries as was contraction in response to the α1-adrenergic agonist cirazoline. Detailed assessment of vascular dimensions revealed increased media thickness and reduced distensibility, arguing that enhanced contraction was due to increased muscle mass. Contrasting with increased α1-adrenergic contraction, myogenic tone was essentially absent and this appeared to be due in part to increased nitric oxide production. Vasomotion was less frequent in the knock-out vessels. In keeping with the opposing influences on arterial resistance of increased agonist-induced contractility and reduced myogenic tone, arterial blood pressure was unchanged in vivo. We conclude that deficiency of cavin-1 affects the function of small arteries, but that opposing influences on arterial resistance balance each other such that systemic blood pressure in unstressed mice is well maintained.

  2. “入声非声”说献疑%Discussion of the Entering Tone is Not a Type of Tone in Ancient and Modern Chinese

    Institute of Scientific and Technical Information of China (English)



    “入声”是中古韵书以及到现代方言研究中的一个重要概念。关于入声的性质,主要有“入声为声”和“入声非声”两种观点。夏中易在前人基础上对入声的性质做了较全面的研究,认为入声的内涵是指塞音韵尾,入声韵的声调是平上去调位的变体。但结合音位学“区别特征”的理论,发现夏先生的音位归纳存在一些问题。中古汉语音节可以分为舒声调系和促声调系,入声作为促声调系和平上去形成的舒声调系相并立。%Entering tone is an important concept in ancient and modern Chinese dialect,which has always been taken as a type of tone Some scholars argue that entering tone is not a type of tone, only a glottal stop.XiaZhongyi emphasized that more.However, some others thought that the entering tone is an independent tone category, which co-exists as the “Cu-tone System” and the“Shu-tone System” in modern Chinese.

  3. The Study of Tone and Related Phenomena in an Amazonian Tone Language: Gavião of Rondônia (United States)

    Moore, Denny; Meyer, Julien


    This paper describes the methods used to study the tone and some related phenomena of the language of the Gavião of Rondônia, Brazil, which is part of the Mondé branch of the Tupi family. Whistling of words by indigenous informants was discovered to be a very effective method for obtaining phonetic accuracy in tone and length. Methods were devised…

  4. Increased wall tension in response to vasoconstrictors in isolated mesenteric arterial rings from patients with high blood pressure. (United States)

    Tahvanainen, Anna; Taurio, Jyrki; Mäki-Jouppi, Jenni; Kööbi, Peeter; Mustonen, Jukka; Kähönen, Mika; Sand, Juhani; Nordback, Isto; Pörsti, Ilkka


    Essential hypertension is associated with several alterations in arterial function. A wealth of information from animal models is available concerning hypertensive changes in the mesenteric circulation, while only few studies have examined human mesenteric arterial function. The tone of isolated mesenteric arterial segments (outer diameter 0.7-0.9 mm) was examined from individuals with high (n=17) or normal (n=22) blood pressure, grouped using the current definition of elevated blood pressure (140/90 mmHg). Since the majority of them were operated because of malignancies, we evaluated whether functional vascular properties provided information about patient prognosis. Wall tension development (mN/mm) in response to vasoconstrictors (noradrenaline, 5-hydroxy tryptamine, potassium chloride) was higher in mesenteric arterial rings from patients with high than normal blood pressure. There was no difference in vasoconstrictor sensitivity, or endothelium-dependent and endothelium-independent vasorelaxation. Arterial segment weight was higher in hypertensive subjects, suggesting vascular wall hypertrophy. The 10-year follow-up showed no differences in the control of arterial tone between the surviving (n=14) or deceased (n=25) patients. In conclusion, isolated mesenteric arterial segments from hypertensive patients showed increased wall tension in response to vasoconstrictors. Since the mesenteric circulation is an important regulator of peripheral arterial resistance, possible functional alterations in this vascular bed should be further investigated in hypertensive patients.

  5. L'effet Casimir : théorie et expériences (United States)

    Lambrecht, A.; Genet, C.; Intravaia, F.; Reynaud, S.


    L'existence de fluctuations irréductibles de champ dans le vide est une prédiction importante de la théorie quantique. Ces fluctuations ont de nombreuses conséquences observables comme l'effet Casimir, qui est maintenant mesuré avec une bonne précision et un bon accord avec la théorie, pourvu que celle-ci tienne compte des différences entre les expériences rélles et la situation idéale considérée par H.G.B. Casimir. Nous présenterons quelqu'unes des expériences récentes et discuterons les principales corrections à la force de Casimir liées à la situation expérimentale.

  6. Bruit thermique et effets quantiques dans une cavité optique de grande finesse (United States)

    Caniard, T.; Briant, T.; Heidmann, A.; Pinard, M.


    Nous nous intéressons aux bruits dans les mesures optiques de très grande sensibilité et aux limites associées. Une des limitations fondamentales des mesures interférométriques, telles que les détections d'ondes gravitationnelles, est liée aux fluctuations de la pression de radiation exercée par la lumière sur les miroirs. Celle-ci induit des corrélations quantiques entre la position des miroirs et les fluctuations de la lumière. L'observation de ces effets quantiques ouvrirait de nombreuses perspectives: étude de la limite quantique standard, production d'états comprimés, réalisation d'une mesure quantique non destructive ldots

  7. Effets oculaires de la tranquilisation avec le buthorphanol chez le chien


    Dongay, Agnès


    Le butorphanol est utilisé en médecine vétérinaire pour ses propriétés analgésiques et sédatives dans divers protocoles anesthésiques L’objectif de cette étude était d’évaluer les effets oculaires de la sédation au butorphanol lors d’un examen ophtalmologique de routine. Vingt-deux beagles sans anomalie oculaire ont reçu une injection intramusculaire de butorphanol à la dose de 0,2 mg/kg. Des examens cliniques répétés ont été effectués 20 minutes avant et juste avant l’administration puis 10,...

  8. Infrastructure numérique et environnement : l'impossible domestication de l'effet rebond


    Flipo, Fabrice; Gossart, Cédric


    International audience; Les technologies numériques de l'information et de la communication (TNIC) se généralisent dans un grand nombre de domaines de la vie collective et domestique. Les puces envahissent notre quotidien : automobiles, PDA, lecteurs MP3, etc. Les TNIC véhiculent une image de légèreté et d'absence de friction. Les coûts de transaction et les frais de transport sont ramenés quasiment à zéro. Leur effet sur l'écologie planétaire semble être nul. Mieux, elles permettent d'observ...

  9. Interactions of the gasotransmitters contribute to microvascular tone (dysregulation in the preterm neonate.

    Directory of Open Access Journals (Sweden)

    Rebecca M Dyson

    Full Text Available Hydrogen sulphide (H2S, nitric oxide (NO, and carbon monoxide (CO are involved in transitional microvascular tone dysregulation in the preterm infant; however there is conflicting evidence on the interaction of these gasotransmitters, and their overall contribution to the microcirculation in newborns is not known. The aim of this study was to measure the levels of all 3 gasotransmitters, characterise their interrelationships and elucidate their combined effects on microvascular blood flow.90 preterm neonates were studied at 24h postnatal age. Microvascular studies were performed by laser Doppler. Arterial COHb levels (a measure of CO were determined through co-oximetry. NO was measured as nitrate and nitrite in urine. H2S was measured as thiosulphate by liquid chromatography. Relationships between levels of the gasotransmitters and microvascular blood flow were assessed through partial correlation controlling for the influence of gestational age. Structural equation modelling was used to examine the combination of these effects on microvascular blood flow and derive a theoretical model of their interactions.No relationship was observed between NO and CO (p = 0.18, r = 0.18. A positive relationship between NO and H2S (p = 0.008, r = 0.28 and an inverse relationship between CO and H2S (p = 0.01, r = -0.33 exists. Structural equation modelling was used to examine the combination of these effects on microvascular blood flow. The model with the best fit is presented.The relationships between NO and H2S, and CO and H2S may be of importance in the preterm newborn, particularly as NO levels in males are associated with higher H2S levels and higher microvascular blood flow and CO in females appears to convey protection against vascular dysregulation. Here we present a theoretical model of these interactions and their overall effects on microvascular flow in the preterm newborn, upon which future mechanistic studies may be based.

  10. Pulmonary function, cholinergic bronchomotor tone, and cardiac autonomic abnormalities in type 2 diabetic patients

    Directory of Open Access Journals (Sweden)

    Melo E.


    Full Text Available This prospective study analyzed the involvement of the autonomic nervous system in pulmonary and cardiac function by evaluating cardiovascular reflex and its correlation with pulmonary function abnormalities of type 2 diabetic patients. Diabetic patients (N = 17 and healthy subjects (N = 17 were evaluated by 1 pulmonary function tests including spirometry, He-dilution method, N2 washout test, and specific airway conductance (SGaw determined by plethysmography before and after aerosol administration of atropine sulfate, and 2 autonomic cardiovascular activity by the passive tilting test and the magnitude of respiratory sinus arrhythmia (RSA. Basal heart rate was higher in the diabetic group (87.8 ± 11.2 bpm; mean ± SD than in the control group (72.9 ± 7.8 bpm, P<0.05. The increase of heart rate at 5 s of tilting was 11.8 ± 6.5 bpm in diabetic patients and 17.6 ± 6.2 bpm in the control group (P<0.05. Systemic arterial pressure and RSA analysis did not reveal significant differences between groups. Diabetes intragroup analysis revealed two behaviors: 10 patients with close to normal findings and 7 with significant abnormalities in terms of RSA, with the latter subgroup presenting one or more abnormalities in other tests and clear evidence of cardiovascular autonomic dysfunction. End-expiratory flows were significantly lower in diabetic patients than in the control group (P<0.05. Pulmonary function tests before and after atropine administration demonstrated comparable responses by both groups. Type 2 diabetic patients have cardiac autonomic dysfunction that is not associated with bronchomotor tone alterations, probably reflecting a less severe impairment than that of type 1 diabetes mellitus. Yet, a reduction of end-expiratory flow was detected.

  11. Effects of Age, Sex, and Body Position on Orofacial Muscle Tone in Healthy Adults (United States)

    Dietsch, Angela M.; Clark, Heather M.; Steiner, Jessica N.; Solomon, Nancy Pearl


    Purpose: Quantification of tissue stiffness may facilitate identification of abnormalities in orofacial muscle tone and thus contribute to differential diagnosis of dysarthria. Tissue stiffness is affected by muscle tone as well as age-related changes in muscle and connective tissue. Method: The Myoton-3 measured tissue stiffness in 40 healthy…

  12. Neural Control of Rising and Falling Tones in Mandarin Speakers Who Stutter (United States)

    Howell, Peter; Jiang, Jing; Peng, Danling; Lu, Chunming


    Neural control of rising and falling tones in Mandarin people who stutter (PWS) was examined by comparing with that which occurs in fluent speakers [Howell, Jiang, Peng, and Lu (2012). Neural control of fundamental frequency rise and fall in Mandarin tones. "Brain and Language, 121"(1), 35-46]. Nine PWS and nine controls were scanned. Functional…

  13. The Effect of Intertalker Variations on Acoustic-Perceptual Mapping in Cantonese and Mandarin Tone Systems (United States)

    Peng, Gang; Zhang, Caicai; Zheng, Hong-Ying; Minett, James W.; Wang, William S.-Y.


    Purpose: This study investigates the impact of intertalker variations on the process of mapping acoustic variations on tone categories in two different tone languages. Method: Pitch stimuli manipulated from four voice ranges were presented in isolation through a blocked-talker design. Listeners were instructed to identify the stimuli that they…

  14. Preserved alpha-adrenergic tone in the leg vascular bed of spinal cord-injured individuals.

    NARCIS (Netherlands)

    Kooijman, H.M.; Rongen, G.A.P.J.M.; Smits, P.; Hopman, M.T.E.


    BACKGROUND: Supraspinal sympathetic control of leg vascular tone is lost in spinal cord-injured individuals, but this does not result in a reduced leg vascular tone: Leg vascular resistance is even increased. The aim of this study was to assess the alpha-adrenergic contribution to the increased vasc

  15. Skin-Tone Preferences and Self-Representation in Hispanic Children (United States)

    Kaufman, Erin A.; Wiese, Deborah L.


    Skin-tone preferences and colourism within Hispanic children have been largely unexamined in the psychological literature. The objectives of the current study were to investigate Hispanic children's skin-tone preferences and the effect of assessor race and ethnicity on those preferences. To carry out the study, Clark and Clark's colouring task was…

  16. Perception of pitch height in lexical and musical tones by English-speaking musicians and nonmusicians. (United States)

    Lee, Chao-Yang; Lekich, Allison; Zhang, Yu


    The purpose of this study was to explore the music-speech relationship by examining pitch height perception in lexical and musical tones. English-speaking musicians and nonmusicians identified multispeaker Taiwanese level tones without typical cues for speaker normalization. The musicians also identified note names of piano, viola, and pure tones without a reference pitch. In the Taiwanese task, both the musicians and nonmusicians were able to identify tone height above chance, but only for tones at the extremes of the speakers' overall vocal range. The musicians only had a slight advantage over the nonmusicians. In the music task, none of the musicians met the criterion for absolute pitch. Timbre did not affect how accurately the musical tones were identified. No correlations were found between performance in the Taiwanese task and that in the music task. It was concluded that musicians' advantage in lexical tone perception arose from the ability to track F0 contours. The ability to identify pitch height in lexical tones appears to involve calibrating acoustic input according to gender-specific, internally stored pitch templates.

  17. Auditory Stream Segregation Improves Infants' Selective Attention to Target Tones Amid Distracters (United States)

    Smith, Nicholas A.; Trainor, Laurel J.


    This study examined the role of auditory stream segregation in the selective attention to target tones in infancy. Using a task adapted from Bregman and Rudnicky's 1975 study and implemented in a conditioned head-turn procedure, infant and adult listeners had to discriminate the temporal order of 2,200 and 2,400 Hz target tones presented alone,…

  18. Spectral broadening of acoustic tones generated by unmanned aerial vehicles in a turbulent atmosphere

    DEFF Research Database (Denmark)

    Ostashev, Vladimir E.; Wilson, D. K.; Finn, Anthony


    The acoustic spectrum emitted by unmanned aerial vehicles (UAVs) and other aircraft can be distorted by propagation through atmospheric turbulence. Since most UAVs are propeller-based, they generate a series of acoustic tones and harmonics. In this paper, spectral broadening of these tones due...

  19. Loudness of brief tones in listeners with normal hearing and sensorineural hearing loss

    DEFF Research Database (Denmark)

    Buus, Søren; Florentine, Mary; Poulsen, Torben


    To investigate how hearing loss affects the loudness of brief tones, loudness matches between 5- and 200-ms tones were obtained as a function of level. Loudness functions derived from these data indicated that the gain required to restore loudness usually is the same for short and long sounds....

  20. A Model of Mandarin Tone Categories--A Study of Perception and Production (United States)

    Yang, Bei


    The current study lays the groundwork for a model of Mandarin tones based on both native speakers' and non-native speakers' perception and production. It demonstrates that there is variability in non-native speakers' tone productions and that there are differences in the perceptual boundaries in native speakers and non-native speakers. There…

  1. Factors Affecting the Production of Vietnamese Tones: A Study of American Learners (United States)

    Nguyen, Hanh thi; Macken, Marlys A.


    This study investigates factors that affect the accuracy of tone production by American students of Vietnamese as a second language (L2). Nine hypotheses are examined, each of which isolates a factor expected to affect production accuracy: (a) task type, (b) the position of a tone in a clause, (c) discourse distance between a model provided by a…

  2. Production and Perception of Mandarin Tone in Adults with Cerebral Palsy (United States)

    Jeng, Jing-Yi; Weismer, Gary; Kent, Ray D.


    The primary objective of the present study was to document tone production and intelligibility deficits in Mandarin-speaking persons with cerebral palsy (CP). Spastic, athetoid, and mixed types of CP were studied, along with a control group, to investigate the possibility of tone production and intelligibility deficits that were differentially…

  3. Learning a Tonal Language by Attending to the Tone: An In Vivo Experiment

    NARCIS (Netherlands)

    Liu, Y.; Wang, M.; Perfetti, C.A.; Brubaker, B.; Wu, S.M.; MacWhinney, B.


    Learning the Chinese tone system is a major challenge to students of Chinese as a second or foreign language. Part of the problem is that the spoken Chinese syllable presents a complex perceptual input that overlaps tone with segments. This complexity can be addressed through directing attention to

  4. Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain. (United States)

    Fairbank, Nigel J; Connolly, Sarah C; Mackinnon, James D; Wehry, Kathrin; Deng, Linhong; Maksym, Geoffrey N


    Chronic contractile activation, or tone, in asthma coupled with continuous stretching due to breathing may be involved in altering the contractile function of airway smooth muscle (ASM). Previously, we (11) showed that cytoskeletal remodeling and stiffening responses to acute (2 h) localized stresses were modulated by the level of contractile activation of ASM. Here, we investigated if altered contractility in response to chronic mechanical strain was dependent on repeated modulation of contractile tone. Cultured human ASM cells received 5% cyclic (0.3 Hz), predominantly uniaxial strain for 5 days, with once-daily dosing of either sham, forskolin, carbachol, or histamine to alter tone. Stiffness, contractility (KCl), and "relaxability" (forskolin) were then measured as was cell alignment, myosin light-chain phosphorylation (pMLC), and myosin light-chain kinase (MLCK) content. Cells became aligned and baseline stiffness increased with strain, but repeated lowering of tone inhibited both effects (P negative tone-modulation dependence of MLCK, observed in static conditions in agreement with previous reports, with strain and tone together increasing both MLCK and pMLC. Furthermore, contractility increased 176% (SE 59) with repeated tone elevation. These findings indicate that with strain, and not without, repeated tone elevation promoted contractile function through changes in cytoskeletal organization and increased contractile protein. The ability of repeated contractile activation to increase contractility, but only with mechanical stretching, suggests a novel mechanism for increased ASM contractility in asthma and for the role of continuous bronchodilator and corticosteroid therapy in reversing airway hyperresponsiveness.

  5. Newborn Pain Cries and Vagal Tone: Parallel Changes in Response to Circumcision. (United States)

    Porter, Fran Lang; And Others


    The relation between cry acoustics and vagal tone in normal, healthy newborns undergoing an acutely stressful event was examined. Vagal tone was significantly reduced during the stressful event and was paralleled by significant increases in the pitch of the infants' cries. (PCB)

  6. Effets économiques de l’aide publique au développement en suisse

    Directory of Open Access Journals (Sweden)

    Gilles Carbonnier


    Full Text Available Cette étude porte sur les effets des dépenses d’aide publique au développement (APD sur l’économie suisse. Elle examine les apports générés par les dépenses d’APD sur le produit intérieur brut (PIB et sur l’emploi en Suisse pour l’année 2010. Il s’agit de la cinquième étude du genre, après celles de 1994, 1998, 2002 et 2006. Ce rapport présente les résultats de manière détaillée. Un résumé synthétique a été publié séparément sur les sites Internet de la DDC1 et du SECO2 en février 2012.L’approche méthodologique consiste à évaluer les retombées économiques induites par les achats de biens et services ainsi que par les salaires versés au titre de l’APD. Dans une première étape, l’étude calcule l’incidence de l’APD sur la demande globale3 en Suisse. Ensuite, elle évalue l’effet multiplicateur de cette hausse initiale de la demande sur le produit intérieur brut (PIB suisse, ce qui permet finalement d’estimer l’impact en termes d’emplois, en fonction de la productivité moyenne du travail en Suisse. Les résultats de cette étude démontrent à nouveau que les dépenses d’APD génèrent des effets clairement positifs pour l’économie suisse. Pour l’année 2010 :- en conservant les mêmes hypothèses de calcul que pour les études précédentes, le volume total de l’APD, de 2,4 milliards de CHF suisses, a généré un apport de revenus de 3,6 milliards de CHF. Autrement dit, chaque CHF d’aide a généré, en moyenne, des retombées de 1,55 CHF sur le PIB suisse. Sur la base de la productivité moyenne du travail en Suisse, les retombées sur le marché du travail sont estimées à 25 000 emplois à plein temps ;- en révisant certaines hypothèses de calcul pour refléter l’évolution de la composition de l’APD et afin d’éviter tout risque de surévaluer les résultats, les retombées par CHF d’APD sur le PIB se montent à 1,29 CHF en moyenne, et l

  7. Positive affective tone and team performance: The moderating role of collective emotional skills. (United States)

    Collins, Amy L; Jordan, Peter J; Lawrence, Sandra A; Troth, Ashlea C


    Research on affect as a group-level phenomenon has shown that over time, individual members within a group become highly similar in their affect (i.e., members experience and display similar emotions and moods), and often become similar enough that the aggregation of individuals' affect can meaningfully represent the "affective tone" of the group. It is generally assumed that a more positive affective tone will lead to better team performance. We challenge the conclusion that positive affective tone is always good for team performance, suggesting that the relationship between positive affective tone and team performance is subject to moderating influences. Across two studies, we demonstrate that the self-reported collective emotional skills of team members play a crucial role in determining whether positive affective tone is beneficial or detrimental to team performance. Implications for theory and practice are discussed.

  8. The development of categorical perception of Mandarin tones in four- to seven-year-old children. (United States)

    Chen, Fei; Peng, Gang; Yan, Nan; Wang, Lan


    To track the course of development in children's fine-grained perception of Mandarin tones, the present study explored how categorical perception (CP) of Mandarin tones emerges along age among 70 four- to seven-year-old children and 16 adults. Prominent discrimination peaks were found for both the child and the adult groups, and they were well aligned with the corresponding identification crossovers. Moreover, six-year-olds showed a much narrower width (i.e. a sharper slope) compared to younger children, and have already acquired adult-like identification competence of Mandarin high-level and mid-rising tones. Although the ability to discriminate within-category tone pairs did not change, the between-category discrimination accuracies were positively correlated with chronological ages among child participants. We assume that the perceptual refinement of Mandarin tones in young children may be driven by an accumulation of perceptual development from the tonal information of the ambient sound input.

  9. Musical experience modulates categorical perception of lexical tones by native Chinese speakers

    Directory of Open Access Journals (Sweden)

    Han eWu


    Full Text Available Although musical training has been shown to facilitate both native and nonnative phonetic perception, it remains unclear whether and how musical experience affects native speakers’ categorical perception (CP of speech at the suprasegmental level. Using both identification and discrimination tasks, this study compared Chinese-speaking musicians and non-musicians in their categorical perception of a lexical tone continuum (from the high level tone, Tone1 to the high falling tone, Tone4. While the identification functions showed similar steepness and boundary location between the two subject groups, the discrimination results revealed superior performance in the musicians for discriminating within-category stimuli pairs but not for between-category stimuli. These findings suggest that musical training can enhance sensitivity to subtle pitch differences between within-category sounds in the presence of robust mental representations in service of categorical perception of lexical tonal contrasts.

  10. Mesenteric artery ischemia (United States)

    ... Mesenteric artery ischemia To use the sharing features on this page, please enable JavaScript. Mesenteric artery ischemia occurs when there is a narrowing or blockage ...

  11. Upper limb arterial thromboembolism

    DEFF Research Database (Denmark)

    Andersen, L V; Lip, Gregory Y.H.; Lindholt, J S;


    The aim of this review is to focus on risk factors, risk-modifying drugs and prognosis for upper limb arterial thromboembolism, and the relationship between upper limb arterial thromboembolism and atrial fibrillation (AF).......The aim of this review is to focus on risk factors, risk-modifying drugs and prognosis for upper limb arterial thromboembolism, and the relationship between upper limb arterial thromboembolism and atrial fibrillation (AF)....

  12. [State of the dopamine system activity, as one of factors for the development of arterial hypertension and obesity]. (United States)

    Lyzogub, V H; Dolynna, O V; Bogdan, T V; Sobol', V O


    The discovery of 5 subtypes of dopamine receptors revealed their important role in development of arterial hypertension and obesity. Reduce of their functional activity or number with age conduces to the increase of tone of the sympathetic nervous system, dyspoiesis of leptin, hyperphagia, development of obesity and arterial hypertension. Prescription of dopamine agonists conduces to reduction of in, normalization of leptin, diminishing of appetite and body mass, decrease of blood pressure. Combination of arterial hypertension and obesity is recommended to determine dopamine excretion and to appoint dopamine agonists at level of < 600 nmol/24 hours.

  13. Effet des chocs de mortalité sur le profil par âge de la mortalité des adultes

    DEFF Research Database (Denmark)

    Zarulli, Virginia


    Quel sont les effets des modifications soudaines des conditions extérieures sur le niveau et les profils par âge de la mortalité humaine ? Divers travaux ont analysé des événements brutaux comme la famine ou la déportation, mais on ne dispose pas d’évaluation systématique de l’effet des chocs sur...

  14. [Upper extremity arterial diseases]. (United States)

    Becker, F


    Compared to lower limb arterial diseases, upper limb arterial diseases look rare, heterogeneous with various etiologies and a rather vague clinical picture, but with a negligible risk of amputation. Almost all types of arterial diseases can be present in the upper limb, but the anatomical and hemodynamic conditions particular to the upper limb often confuse the issue. Thus, atherosclerosis affects mainly the subclavian artery in its proximal segment where the potential of collateral pathway is high making the symptomatic forms not very frequent whereas the prevalence of subclavian artery stenosis or occlusion is relatively high. The clinical examination and the etiologies are discussed according to the clinical, anatomical and hemodynamic context.

  15. Modulatory compartments in cortex and local regulation of cholinergic tone. (United States)

    Coppola, Jennifer J; Ward, Nicholas J; Jadi, Monika P; Disney, Anita A


    Neuromodulatory signaling is generally considered broad in its impact across cortex. However, variations in the characteristics of cortical circuits may introduce regionally-specific responses to diffuse modulatory signals. Features such as patterns of axonal innervation, tissue tortuosity and molecular diffusion, effectiveness of degradation pathways, subcellular receptor localization, and patterns of receptor expression can lead to local modification of modulatory inputs. We propose that modulatory compartments exist in cortex and can be defined by variation in structural features of local circuits. Further, we argue that these compartments are responsible for local regulation of neuromodulatory tone. For the cholinergic system, these modulatory compartments are regions of cortical tissue within which signaling conditions for acetylcholine are relatively uniform, but between which signaling can vary profoundly. In the visual system, evidence for the existence of compartments indicates that cholinergic modulation likely differs across the visual pathway. We argue that the existence of these compartments calls for thinking about cholinergic modulation in terms of finer-grained control of local cortical circuits than is implied by the traditional view of this system as a diffuse modulator. Further, an understanding of modulatory compartments provides an opportunity to better understand and perhaps correct signal modifications that lead to pathological states.

  16. New postage stamp design with tone gradation in Infraredesign technology

    Directory of Open Access Journals (Sweden)

    Maja Rudolf


    Full Text Available This paper deals with the application of new steganographic methods in postage stamp printing technology with the goal of securing them against counterfeiting. Postage stamp designs are presented which contain double information in the visible and in the infrared spectrum area. New methods include printing with process printing inks that have a continuous response in the infrared area of the spectrum. The infrared Z image cannot be produced with conventional CMYK separation in such a way that the hidden picture does not show through when looking at the print. This is the reason for introducing CMYKIR separation, with mathematical relations that respect printing ink characteristics in the RGB to CMYKIR system conversion.A mathematical model with targeted separation characteristics is proposed, with seven independent variables. It has been created as the result of optimal regression model developed on the basis of colour tone measuring for the visual and infrared spectrum. A technological procedure has been elaborated for producing and printing based on such designs. It is possible to detect the infrared image with the help of a device – the infrared ZRGB camera. Counterfeiting is impossible due to the irreversible conversion of the CMYKIR separation into the RGB system applied in contemporary scanners or cameras.

  17. Hand proximity facilitates spatial discrimination of auditory tones

    Directory of Open Access Journals (Sweden)

    Philip eTseng


    Full Text Available The effect of hand proximity on vision and visual attention has been well documented. In this study we tested whether such effect(s would also be present in the auditory modality. With hands placed either near or away from the audio sources, participants performed an auditory-spatial discrimination (Exp 1: left or right side, pitch discrimination (Exp 2: high, med, or low tone, and spatial-plus-pitch (Exp 3: left or right; high, med, or low discrimination task. In Exp 1, when hands were away from the audio source, participants consistently responded faster with their right hand regardless of stimulus location. This right hand advantage, however, disappeared in the hands-near condition because of a significant improvement in left hand’s reaction time. No effect of hand proximity was found in Exp 2 or 3, where a choice reaction time task requiring pitch discrimination was used. Together, these results suggest that the effect of hand proximity is not exclusive to vision alone, but is also present in audition, though in a much weaker form. Most important, these findings provide evidence from auditory attention that supports the multimodal account originally raised by Reed et al. in 2006.

  18. Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension


    Monaco TJ; Davila CD


    Thomas J Monaco,1 Carlos D Davila2 1Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, 2Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA Abstract: Pulmonary arterial hypertension is a progressive, debilitating disease caused by a dysregulation of the pulmonary vascular tone that inevitably leads to right heart failure and death without treatment. Until relatively recently, the treatment options for those afflicted by pulmonary ar...

  19. Anticuerpos anticardiolipina en pacientes con hipertensión arterial esencial


    Diumenjo, M. S.; Testasecca, E.; Testasecca, A.; Maneschi, E.


    Los anticuerpos antifosfolípidos pueden activar el endotelio, modificar su función, alterar la regulación del tono vascular, producir daño renal, y así participar en la patogenia de la hipertensión arterial esencial. Antiphospholipid antibodies can activate the endothelium, alter their function, alter the regulation of vascular tone, cause kidney damage, and thus participate in the pathogenesis of essential hypertension. Fil: Diumenjo, M. S.. Universidad Nacional de Cuyo...

  20. Transradial artery coronary angioplasty. (United States)

    Kiemeneij, F; Laarman, G J; de Melker, E


    This study explored the feasibility and safety of percutaneous coronary balloon angioplasty (PTCA) with miniaturized PTCA equipment via the radial artery. Coronary angioplasty (PTCA) via the femoral or brachial arteries may be associated with rare vascular complications such as bleeding and damage to the artery and adjacent structures. It was postulated that PTCA via the radial artery with miniaturized angioplasty equipment is feasible and that no major puncture site-related complications occur because hemostasis is obtained easily and because no major structures are near the radial artery. With double blood supply to the hand, radial artery occlusion is well tolerated. In 100 patients with collateral blood supply to the right hand, PTCA was attempted with 6F guiding catheters and rapid-exchange balloon catheters for exertional angina (87 patients) or nonexertional angina (13 patients). Angioplasty was attempted in 122 lesions (type A n = 67 [55%], Type B n = 37 [30%], and type C n = 18 [15%]). Pre- and post-PTCA computerized quantitative coronary analysis was performed. Radial artery function and structure were assessed clinically and with Doppler and two-dimensional ultrasound on the day of discharge. Coronary catheterization via the radial artery was successful in 94 patients (94%). The 6 remaining patients had successful PTCA via the femoral artery (n = 5) or the brachial artery (n = 1). Procedural success (120 of 122 lesions) was achieved in 92 patients (98%) via the radial artery and in 98 patients of the total study population.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Development of low postural tone compensatory patterns in children - theoretical basis. (United States)

    Gogola, Anna; Saulicz, Edward; Kuszewski, Michał; Matyja, Małgorzata; Myśliwiec, Andrzej


    Neurological literature indicates the existence of children with low postural tone without association with central nervous system damage. This fact induces to think about mechanisms, which allow these children to maintain upright posture. There is a suspicion that compensatory mechanism included in this process, enables to achieve upright posture, but at expense of body posture quality. Observations of children's developmental stages caused determination of some postural tone area, which comprise both children with normotonia and with low postural tone without characteristics of central nervous system (CNS) damage. Set of specific qualities allows determination of two types of low postural tone: spastoidal and atetoidal type. Spastoidal type is characterized by deep trunk muscles (local) low postural tone compensated by excessive tension of superficial muscles (global). Atetoidal type includes children with low postural tone in both deep and superficial muscles. At inefficient active subsystem, verticalization proceeds at excessive use of passive subsystem qualities, that is meniscus, ligament, bone shape, and muscles passive features. From neurodevelopmental point of view compensatory mechanisms can be used in children with low postural tone in order to achieve upright posture, but at expense of body posture quality.

  2. A statistical study of EMIC rising and falling tone emissions observed by THEMIS (United States)

    Nakamura, Satoko; Omura, Yoshiharu; Angelopoulos, Vassilis


    Electromagnetic ion cyclotron (EMIC) waves with rising or falling frequency variations have been studied intensively because of their effects on energetic particles in the Earth's magnetosphere. We develop an automated classification method of EMIC events based on the characteristics of frequency variations. We report some basic statistical properties of frequency variations in EMIC waves observed over 5-10 RE by three Time History of Events and Macroscale Interactions during Substorms probes from January 2012 to December 2014. We clarify whether rising tones or falling tones are observed in each chosen 20 min time segment. In the present analysis, we find that the occurrence rate of EMIC rising or falling tone events is more than 30% of the total EMIC wave events. The dayside magnetosphere is a preferential region for the EMIC frequency variations. The occurrence rate of rising tone events is slightly greater than that of falling tone events. We examine the relation between the frequency characteristics and the magnetospheric conditions. The solar wind pressure strongly controls the occurrence rates of frequency variations. We also calculate ranges of frequency variations. Large-amplitude EMIC waves tend to have wider frequency variations, and the range of frequency variation is largest around the prenoon region. In addition, rapid variations in wave amplitudes called "subpacket structures" are found in 70% of the EMIC rising or falling tone events in the dayside region. Subpacket structures appear mainly in large-amplitude EMIC rising or falling tones. These features are consistent with nonlinear wave growth theory.

  3. Effet d’un stress hydrique de début et de fin de cycle chez le pois


    Marolleau, Jérémie


    La sécheresse est un des facteurs limitant le plus important pour les cultures de pois et affecte chaque année la qualité et la quantité des récoltes. Dans le but de mieux comprendre les réactions du pois au stress hydrique, deux expériences ont été menées. Une première expérience qui a pour but d’évaluer l’effet d’un stress hydrique en phase végétative ainsi que l’effet d’une ré-humectation sur le compartiment racinaire (racine et nodules). Le stage a porté sur l’analyse d’image de feuilles ...

  4. Les gaz à effet de serre en élevage bovin : évaluation et leviers d'action


    Dollé, Jean-Baptiste; Agabriel, Jacques; Peyraud, Jean-Louis; Faverdin, Philippe; Manneville, Vincent; Raison, Christelle; Gac, Armelle; Le Gall, André


    Le contexte environnemental actuel, tant politique (objectifs de réduction des émissions de gaz à effet de serre) que sociétal (information du consommateur), nécessite de préciser les impacts de l'activité d'élevage bovin en matière de changement climatique. L'enjeu est de connaître précisément les niveaux d'émissions de gaz à effet de serre (GES) et de stockage de carbone, des différents modes de production. Pour cela, une évaluation basée sur la méthodologie de l'Analyse du Cycle de Vie (AC...

  5. Modèle de diélectrique associant les effets Poole-Frenkel et Maxwell-Wagner



    Le modèle présenté associe les effets Poole-Frenkel (PF) et Maxwell-Wagner (MW) dans la détermination de la conductivité équivalente σ d'un diélectrique plan à deux couches. L'effet PF y est introduit sous sa forme usuelle (statistique de Boltzmann), puis sous une forme plus générale (statistique de Fermi-Dirac). Les courbes log σ en fonction du champ électrique $(\\sqrt{F})$ présentent généralement une ou deux parties linéaires, la pente en bas champs étant toujours supérieure à la pente en h...

  6. Discrete tone noise on two-dimensional wing. Active control for discrete tone; Nijigen seishiyoku kara hasseisuru risan shuhasu soon no kenkyu. Risan shuhasu soon no nodo seigyo

    Energy Technology Data Exchange (ETDEWEB)

    Nakashima, S. [Mitsubishi Electric Corp., Tokyo (Japan); Akishita, S. [Ritsumeikan University, Kyoto (Japan). Faculty of Science and Engineering


    The active noise control of discrete tones generated in a uniform jet flow on a two-dimensional wing was investigated. Discrete tone noise is generated by a self-excited feedback loop formed by the acoustic field and the unstable boundary layer. In this work, we conducted an active control experiment using a flap driven by piezoceramic levers, which can vibrate with a phase delayed from the velocity fluctuation signal on the suction side. When the flap motion lags the pressure fluctuation at the trailing edge with a phase angle of 180 degrees, it was found that the discrete tone noise was reduced by a maximum of about 7 dB, the flow fluctuation intensities in the boundary layer on the suction side were reduced by about half, and the correlation area of the flow fluctuation at the trailing edge decreased. This confirms that discrete tone generation is caused by the feedback loop and that the discrete tone generation is actively reduced by trailing edge control. 10 refs., 14 figs.

  7. Effects of Temporal Sequencing and Auditory Discrimination on Children's Memory Patterns for Tones, Numbers, and Nonsense Words (United States)

    Gromko, Joyce Eastlund; Hansen, Dee; Tortora, Anne Halloran; Higgins, Daniel; Boccia, Eric


    The purpose of this study was to determine whether children's recall of tones, numbers, and words was supported by a common temporal sequencing mechanism; whether children's patterns of memory for tones, numbers, and nonsense words were the same despite differences in symbol systems; and whether children's recall of tones, numbers, and nonsense…

  8. Effects of Suprasegmental Phonological Alternations on Early Word Recognition: Evidence from Tone Sandhi

    Directory of Open Access Journals (Sweden)

    Thilanga Dilum Wewalaarachchi


    Full Text Available Early language acquisition is potentially complicated by the presence of many sources of variability in the speech signal. A frequent example of variability is phonological alternations, which can lead to context-driven changes in the realization of a word. The aim of the current study was to investigate effects of a highly frequent yet scarcely researched type of suprasegmental phonological alternation – tone Sandhi – on early spoken word recognition. The tone Sandhi rule investigated herein involves a tone change of the first syllable in a disyllabic unit. In accordance with third tone Sandhi, when two dipping tone syllables are juxtaposed in connected speech, the first syllable is dissimilated to a high rising tone. For example, ‘flour mill’ (unaltered pre-Sandhi form [fən(214 tʂʰɑŋ(214] undergoes tonal alternation resulting in the altered post-Sandhi form [fən(35 tʂʰɑŋ(214]. In the current study, preschoolers’ sensitivity to the effects of tone Sandhi when processing familiar words was investigated via a preferential looking paradigm. Words varied in their phonological form: words that were labeled with a phonological alternation due to Sandhi (Post-Sandhi; words that were labeled with an unaltered form when tone Sandhi was licensed (Pre-Sandhi; non-Sandhi words correctly produced (Correct Pronunciation; and words labeled with a phonological alternation of tone not associated with Sandhi rules (Mispronunciation. Post-Sandhi forms and correct pronunciations were associated with visual referents with comparable strength, with only a subtle processing cost observed for post-Sandhi forms in the time course of lexical selection. Likewise, pre-Sandhi forms and true mispronunciations were rejected as labels for visual references with comparable strength, with only subtle differences observed in the time course of lexical selection. Findings are discussed in terms of their impact on prevailing theories of lexical representation.

  9. Acute occlusion of the left subclavian artery with artery dissection

    Institute of Scientific and Technical Information of China (English)


    @@ Subclavian steal syndrome is cerebral or brain stem ischemia resulting from diversion of blood flow from the basilar artery to the subclavian artery, which is caused by occlusive disease of either the subclavian artery or the innominate artery before they branch off at the vertebral artery. In the patients with subclavian steal syndrome the subclavian artery is fed by retrograde flow from the vertebral artery via the carotids and the circle of Willis.

  10. Effets Seebeck et Nernst dans les cuprates: Etude de la reconstruction de la surface de Fermi sous champ magnetique intense (United States)

    Laliberte, Francis


    Ce memoire presente des mesures de transport thermoelectrique, les effets Seebeck et Nernst, dans une serie d'echantillons de supraconducteurs a haute temperature critique. Des resultats obtenus recemment au Laboratoire National des Champs Magnetiques Intenses a Grenoble sur La1.7Eu0.2Sr0.1 CuO4, La1.675Eu0.2Sr0.125CuO 4, La1.64Eu0.2Sr0.16CuO4, La1.74Eu0.1Sr0.16CuO4 et La 1.4Nd0.4Sr0.2CuO4 sont analyses. Une attention particuliere est accordee aux equations de la theorie semi-classique du transport et leur validite est verifiee. La procedure experimentale et les materiaux utilises pour concevoir les montages de mesures sont expliques en detail. Enfin, un chapitre est dedie a l'explication et l'interpretation des resultats de transport thermoelectrique sur YBa2Cu3O6+delta publies au cours de l'hiver 2010 dans les revues Nature et Physical Review Letters. Les donnees d'effet Seebeck dans les echantillons de La 1.8-x,Eu0.2SrxCuO 4, ou un changement de signe est observe, permettent de conclure a la presence d'une poche d'electrons dans la surface de Fermi qui domine le transport a basse temperature dans la region sous-dopee du diagramme de phase. Cette conclusion est similaire a celle obtenue par des mesures d'effet Hall dans YBa 2Cu3O6+delta et elle cadre bien dans un scenario de reconstruction de la surface de Fermi. Les donnees d'effet Nernst recueillies indiquent que la contribution des fluctuations supraconductrices est limitee a un modeste intervalle de temperature au-dessus de la temperature critique.

  11. Heart rate complexity and attentional orienting: a new look at the role of vagal tone. (United States)

    Balle, Maria; Morillas, Alfonso; Tortella-Feliu, Miquel; Bornas, Xavier


    This study is aimed at elucidating (a) whether heart rate (HR) complexity measures are associated with the attentional orienting function, and (b) which of these measures better predicts orienting efficiency indexes. Vagal tone, sample entropy, scaling exponents ?1 and ?2, and fractal dimension (FD) were calculated in HR time series (n=109). Vagal tone, entropy, and FD were positively associated with orienting, while this association was negative for ?2. These results show that HR scaling properties, which underlie the role of vagal tone and reflect allometric control mechanisms, are associated with orienting deficits. FD was the best predictor of attentional orienting.

  12. Use of a digital tone extractor for real-time phase analysis (United States)

    Sigman, E.; Parks, G. S.


    A digital tone extractor which monitors the phase integrity of a VLBI recording system in real time was developed. The digital tone extractor monitors phase calibrator tones injected at the antenna and tracks their phase as a function of time. It is capable of maintaining 0.001 cycle phase accuracy over the course of a VLBI experiment in accordance with the accuracy requirements of centimeter VLBI work. This real time VLBI system monitor is a safeguard against most instrumental breakdowns and operator errors.

  13. Bilateral accessory thoracodorsal artery. (United States)

    Natsis, Konstantinos; Totlis, Trifon; Tsikaras, Prokopios; Skandalakis, Panagiotis


    The subscapular artery arises from the third part of the axillary artery and gives off the circumflex scapular and the thoracodorsal arteries. Although anatomical variations of the axillary artery are very common, the existence of a unilateral accessory thoracodorsal artery has been described in the literature only once. There are no reports of bilateral accessory thoracodorsal artery, in the literature. In the present study, a bilateral accessory thoracodorsal artery, originating on either side of the third part of the axillary artery, is described in a 68-year-old female cadaver. All the other branches of the axillary artery had a typical origin, course, distribution and termination. This extremely rare anatomical variation apart from the anatomical importance also has clinical significance for surgeons in this area. Especially, during the dissection or mobilization of the latissimus dorsi that is partly used for coverage problems in many regions of the body and also in dynamic cardiomyoplasty, any iatrogenic injury of this accessory artery may result in ischemia and functional loss of the graft.

  14. Songbirds use pulse tone register in two voices to generate low-frequency sound

    DEFF Research Database (Denmark)

    Jensen, Kenneth Kragh; Cooper, Brenton G.; Larsen, Ole Næsbye


    generation alternates between the left and right sound sources. Spontaneously calling crows can also generate similar pulse characteristics with only one sound generator. Airflow recordings in zebra finches and starlings show that pulse tone sounds can be generated unilaterally, synchronously...

  15. Response time effects of alerting tone and semantic context for synthesized voice cockpit warnings (United States)

    Simpson, C. A.; Williams, D. H.


    Some handbooks and human factors design guides have recommended that a voice warning should be preceded by a tone to attract attention to the warning. As far as can be determined from a search of the literature, no experimental evidence supporting this exists. A fixed-base simulator flown by airline pilots was used to test the hypothesis that the total 'system-time' to respond to a synthesized voice cockpit warning would be longer when the message was preceded by a tone because the voice itself was expected to perform both the alerting and the information transfer functions. The simulation included realistic ATC radio voice communications, synthesized engine noise, cockpit conversation, and realistic flight routes. The effect of a tone before a voice warning was to lengthen response time; that is, responses were slower with an alerting tone. Lengthening the voice warning with another work, however, did not increase response time.

  16. 17 Ways to Say Yes: Toward Nuanced Tone of Voice in AAC and Speech Technology. (United States)

    Pullin, Graham; Hennig, Shannon


    People with complex communication needs who use speech-generating devices have very little expressive control over their tone of voice. Despite its importance in human interaction, the issue of tone of voice remains all but absent from AAC research and development however. In this paper, we describe three interdisciplinary projects, past, present and future: The critical design collection Six Speaking Chairs has provoked deeper discussion and inspired a social model of tone of voice; the speculative concept Speech Hedge illustrates challenges and opportunities in designing more expressive user interfaces; the pilot project Tonetable could enable participatory research and seed a research network around tone of voice. We speculate that more radical interactions might expand frontiers of AAC and disrupt speech technology as a whole.

  17. Pitch Perception in the First Year of Life, a Comparison of Lexical Tones and Musical Pitch (United States)

    Chen, Ao; Stevens, Catherine J.; Kager, René


    Pitch variation is pervasive in speech, regardless of the language to which infants are exposed. Lexical tone is influenced by general sensitivity to pitch. We examined whether the development in lexical tone perception may develop in parallel with perception of pitch in other cognitive domains namely music. Using a visual fixation paradigm, 100 and one 4- and 12-month-old Dutch infants were tested on their discrimination of Chinese rising and dipping lexical tones as well as comparable three-note musical pitch contours. The 4-month-old infants failed to show a discrimination effect in either condition, whereas the 12-month-old infants succeeded in both conditions. These results suggest that lexical tone perception may reflect and relate to general pitch perception abilities, which may serve as a basis for developing more complex language and musical skills. PMID:28337157

  18. Preliminary Evidence of Preattentive Distinctions of Frequency-Modulated (FM tones that Convey Affect

    Directory of Open Access Journals (Sweden)

    David I Leitman


    Full Text Available Recognizing emotion is an evolutionary imperative. An early stage of auditory scene analysis involves the perceptual grouping of acoustic features, which can be based on both temporal coincidence and spectral features such as perceived pitch. Perceived pitch, or fundamental frequency (F0, is an especially salient cue for differentiating affective intent through speech intonation (prosody. We hypothesized that: 1 simple frequency modulated (FM tone abstractions, based on the parameters of actual prosodic stimuli, would be reliably classified as representing differing emotional categories; and 2 that such differences would yield significant mismatch negativities (MMNs - an index of preattentive deviance detection within the auditory environment. We constructed a set of FM tones that approximated the F0 mean and variation of reliably-recognized happy and neutral prosodic stimuli. These stimuli were presented to 13 subjects using a passive listening oddball paradigm. We additionally included stimuli with no frequency modulation (FM and FM tones with identical carrier frequencies but differing modulation depths as control conditions. Following electrophysiological recording, subjects were asked to identify the sounds they heard as happy, sad, angry or neutral. We observed that FM tones abstracted from happy and no expression speech stimuli elicited MMNs. Post-hoc behavioral testing revealed that subjects reliably identified the FM tones in a consistent manner. Finally, we also observed that FM tones and no-FM tones elicited equivalent MMNs. MMNs to FM tones that differentiate affect suggests that these abstractions may be sufficient to characterize prosodic distinctions, and that these distinctions can be represented in pre-attentive auditory sensory memory.

  19. Pure-Tone-Spondee Threshold Relationships in Functional Hearing Loss: A Test of Loudness Contribution (United States)

    Schlauch, Robert S.; Han, Heekyung J.; Yu, Tzu-Ling J.; Carney, Edward


    Purpose: The purpose of this article is to examine explanations for pure-tone average-spondee threshold differences in functional hearing loss. Method: Loudness magnitude estimation functions were obtained from 24 participants for pure tones (0.5 and 1.0 kHz), vowels, spondees, and speech-shaped noise as a function of level (20-90 dB SPL).…

  20. Lower cardiac vagal tone in non-obese healthy men with unfavorable anthropometric characteristics

    Directory of Open Access Journals (Sweden)

    Plínio S. Ramos


    Full Text Available OBJECTIVES: to determine if there are differences in cardiac vagal tone values in non-obese healthy, adult men with and without unfavorable anthropometric characteristics. INTRODUCTION: It is well established that obesity reduces cardiac vagal tone. However, it remains unknown if decreases in cardiac vagal tone can be observed early in non-obese healthy, adult men presenting unfavorable anthropometric characteristics. METHODS: Among 1688 individuals assessed between 2004 and 2008, we selected 118 non-obese (BMI <30 kg/m², healthy men (no known disease conditions or regular use of relevant medications, aged between 20 and 77 years old (42 ± 12-years-old. Their evaluation included clinical examination, anthropometric assessment (body height and weight, sum of six skinfolds, waist circumference and somatotype, a 4-second exercise test to estimate cardiac vagal tone and a maximal cardiopulmonary exercise test to exclude individuals with myocardial ischemia. The same physician performed all procedures. RESULTS: A lower cardiac vagal tone was found for the individuals in the higher quintiles - unfavorable anthropometric characteristics - of BMI (p=0.005, sum of six skinfolds (p=0.037 and waist circumference (p<0.001. In addition, the more endomorphic individuals also presented a lower cardiac vagal tone (p=0.023, while an ectomorphic build was related to higher cardiac vagal tone values as estimated by the 4-second exercise test (r=0.23; p=0.017. CONCLUSIONS: Non-obese and healthy adult men with unfavorable anthropometric characteristics tend to present lower cardiac vagal tone levels. Early identification of this trend by simple protocols that are non-invasive and risk-free, using select anthropometric characteristics, may be clinically useful in a global strategy to prevent cardiovascular disease.

  1. Celiac Artery Compression Syndrome

    Directory of Open Access Journals (Sweden)

    Mohammed Muqeetadnan


    Full Text Available Celiac artery compression syndrome is a rare disorder characterized by episodic abdominal pain and weight loss. It is the result of external compression of celiac artery by the median arcuate ligament. We present a case of celiac artery compression syndrome in a 57-year-old male with severe postprandial abdominal pain and 30-pound weight loss. The patient eventually responded well to surgical division of the median arcuate ligament by laparoscopy.

  2. Popliteal artery entrapment syndrome.

    LENUS (Irish Health Repository)

    O'Leary, D P


    Popliteal artery entrapment syndrome is a rare abnormality of the anatomical relationship between the popliteal artery and adjacent muscles or fibrous bands in the popliteal fossa. The following is a case report of a 19 year old female, in whom popliteal artery entrapment syndrome was diagnosed, and successfully treated surgically. A review of literature is also presented and provides details on how PAES is classified, diagnosed both clinically and radiologically, and treated surgically.

  3. The serotonin 5-Hydroxytryptaphan1A receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin, stimulates sympathetic-dependent increases in venous tone during hypovolemic shock. (United States)

    Tiniakov, Ruslan; Scrogin, Karie E


    Adjuvant treatment of hypovolemic shock with vasoconstrictors is controversial due to their propensity to raise arterial resistance and exacerbate ischemia. A more advantageous therapeutic approach would use agents that also promote venoconstriction to augment perfusion pressure through increased venous return. Recent studies indicate that 5-hydroxytryptophan (5-HT)(1A) receptor agonists increase blood pressure by stimulating sympathetic drive when administered after acute hypotensive hemorrhage. Given that venous tone is highly dependent upon sympathetic activation of alpha(2)-adrenergic receptors, we hypothesized that the 5-HT(1A) receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), would increase venous tone in rats subject to hypovolemic shock through sympathetic activation of alpha(2)-adrenergic receptors. Systemic administration of 8-OH-DPAT produced a sustained rise in blood pressure (+44 +/- 3 mm Hg 35 min after injection, P hypovolemic shock. An equipressor infusion of epinephrine failed to influence mean circulatory filling pressure (MCFP). Ganglionic blockade, alpha(1)-, or peripheral alpha(2)-adrenergic receptor blockade prevented the rise in MCFP observed with 8-OH-DPAT, but only alpha(1)-adrenergic receptor blockade diminished the pressor effect of the drug (P hypovolemic shock through both direct vascular activation and sympathetic activation of alpha(1)-adrenergic receptors. The sympathoexcitatory effect of 8-OH-DPAT contributes to elevated venous tone through concurrent activation of both alpha(1)- and alpha(2)-adrenergic receptors. The data suggest that 5-HT(1A) receptor agonists may provide an advantageous alternative to currently therapeutic interventions used to raise perfusion pressure in hypovolemic shock.

  4. Arterial waveform analysis. (United States)

    Esper, Stephen A; Pinsky, Michael R


    The bedside measurement of continuous arterial pressure values from waveform analysis has been routinely available via indwelling arterial catheterization for >50 years. Invasive blood pressure monitoring has been utilized in critically ill patients, in both the operating room and critical care units, to facilitate rapid diagnoses of cardiovascular insufficiency and monitor response to treatments aimed at correcting abnormalities before the consequences of either hypo- or hypertension are seen. Minimally invasive techniques to estimate cardiac output (CO) have gained increased appeal. This has led to the increased interest in arterial waveform analysis to provide this important information, as it is measured continuously in many operating rooms and intensive care units. Arterial waveform analysis also allows for the calculation of many so-called derived parameters intrinsically created by this pulse pressure profile. These include estimates of left ventricular stroke volume (SV), CO, vascular resistance, and during positive-pressure breathing, SV variation, and pulse pressure variation. This article focuses on the principles of arterial waveform analysis and their determinants, components of the arterial system, and arterial pulse contour. It will also address the advantage of measuring real-time CO by the arterial waveform and the benefits to measuring SV variation. Arterial waveform analysis has gained a large interest in the overall assessment and management of the critically ill and those at a risk of hemodynamic deterioration.

  5. The effects of pitch and duration on the perception of the neutral tone in standard Chinese

    Institute of Scientific and Technical Information of China (English)

    WANG Yunjia


    The research aim is to investigate that how pitch and duration affect the perception of the neutral tone in standard Chinese and that which one of the two factors is more important.A psycho-acoustic experiment was conducted, in which the listening stimuli consisted of 15 groups of disyllabic words, and the pitches and durations of the two syllables in each of the words were artificially controlled. Thirty-three standard Chinese native speakers participated in a forced-choice task to judge if the second syllables of the words they heard carried the neutral tone or the normal tones. The results of the experiment indicated that, (1) the effects of both pitch and duration on the perception of the neutral tone are significant; (2) the effect of pitch is larger than that of duration; (3) both the Fo values of the high point in the pitch contour and the pitch contour pattern have influence on the perception. The results of the experiment were correspondent to some extent to those of the previous acoustic analyses on the neutral tone.The diversity between the results of the presented perceptual study and those of the acoustical studies implies that the acoustic features of the neutral tone that exist in natural speech while do not affect the perception may be phonologically redundant.

  6. Hardware Implementation of an Automatic Rendering Tone Mapping Algorithm for a Wide Dynamic Range Display

    Directory of Open Access Journals (Sweden)

    Orly Yadid-Pecht


    Full Text Available Tone mapping algorithms are used to adapt captured wide dynamic range (WDR scenes to the limited dynamic range of available display devices. Although there are several tone mapping algorithms available, most of them require manual tuning of their rendering parameters. In addition, the high complexities of some of these algorithms make it difficult to implement efficient real-time hardware systems. In this work, a real-time hardware implementation of an exponent-based tone mapping algorithm is presented. The algorithm performs a mixture of both global and local compression on colored WDR images. An automatic parameter selector has been proposed for the tone mapping algorithm in order to achieve good tone-mapped images without manual reconfiguration of the algorithm for each WDR image. Both algorithms are described in Verilog and synthesized for a field programmable gate array (FPGA. The hardware architecture employs a combination of parallelism and system pipelining, so as to achieve a high performance in power consumption, hardware resources usage and processing speed. Results show that the hardware architecture produces images of good visual quality that can be compared to software-based tone mapping algorithms. High peak signal-to-noise ratio (PSNR and structural similarity (SSIM scores were obtained when the results were compared with output images obtained from software simulations using MATLAB.

  7. Absolute pitch among students in an American music conservatory: association with tone language fluency. (United States)

    Deutsch, Diana; Dooley, Kevin; Henthorn, Trevor; Head, Brian


    Absolute pitch (AP), the ability to name a musical note in the absence of a reference note, is extremely rare in the U.S. and Europe, and its genesis is unclear. The prevalence of AP was examined among students in an American music conservatory as a function of age of onset of musical training, ethnicity, and fluency in speaking a tone language. Taking those of East Asian ethnicity, the performance level on a test of AP was significantly higher among those who spoke a tone language very fluently compared with those who spoke a tone language fairly fluently and also compared with those who were not fluent in speaking a tone language. The performance level of this last group did not differ significantly from that of Caucasian students who spoke only nontone language. Early onset of musical training was associated with enhanced performance, but this did not interact with the effect of language. Further analyses showed that the results could not be explained by country of early music education. The findings support the hypothesis that the acquisition of AP by tone language speakers involves the same process as occurs in the acquisition of a second tone language.

  8. Repetition Suppression in the Left Inferior Frontal Gyrus Predicts Tone Learning Performance. (United States)

    Asaridou, Salomi S; Takashima, Atsuko; Dediu, Dan; Hagoort, Peter; McQueen, James M


    Do individuals differ in how efficiently they process non-native sounds? To what extent do these differences relate to individual variability in sound-learning aptitude? We addressed these questions by assessing the sound-learning abilities of Dutch native speakers as they were trained on non-native tone contrasts. We used fMRI repetition suppression to the non-native tones to measure participants' neuronal processing efficiency before and after training. Although all participants improved in tone identification with training, there was large individual variability in learning performance. A repetition suppression effect to tone was found in the bilateral inferior frontal gyri (IFGs) before training. No whole-brain effect was found after training; a region-of-interest analysis, however, showed that, after training, repetition suppression to tone in the left IFG correlated positively with learning. That is, individuals who were better in learning the non-native tones showed larger repetition suppression in this area. Crucially, this was true even before training. These findings add to existing evidence that the left IFG plays an important role in sound learning and indicate that individual differences in learning aptitude stem from differences in the neuronal efficiency with which non-native sounds are processed.

  9. Synthesis of Polysyllabic Sequences of Thai Tones Using a Generative Model of Fundamental Frequency Contours (United States)

    Seresangtakul, Pusadee; Takara, Tomio

    In this paper, the distinctive tones of Thai in running speech are studied. We present rules to synthesize F0 contours of Thai tones in running speech by using the generative model of F0 contours. Along with our method, the pitch contours of Thai polysyllabic words, both disyllabic and trisyllabic words, were analyzed. The coarticulation effect of Thai tones in running speech were found. Based on the analysis of the polysyllabic words using this model, rules are derived and applied to synthesize Thai polysyllabic tone sequences. We performed listening tests to evaluate intelligibility of the rules for Thai tones generation. The average intelligibility scores became 98.8%, and 96.6% for disyllabic and trisyllabic words, respectively. From these result, the rule of the tones' generation was shown to be effective. Furthermore, we constructed the connecting rules to synthesize suprasegmental F0 contours using the trisyllable training rules' parameters. The parameters of the first, the third, and the second syllables were selected and assigned to the initial, the ending, and the remaining syllables in a sentence, respectively. Even such a simple rule, the synthesized phrases/senetences were completely identified in listening tests. The MOSs (Mean Opinion Score) was 3.50 while the original and analysis/synthesis samples were 4.82 and 3.59, respectively.

  10. Inhibition of α-adrenergic tone disturbs the distribution of blood flow in the exercising human limb. (United States)

    Heinonen, Ilkka; Wendelin-Saarenhovi, Maria; Kaskinoro, Kimmo; Knuuti, Juhani; Scheinin, Mika; Kalliokoski, Kari K


    The role of neuronal regulation of human cardiovascular function remains incompletely elucidated, especially during exercise. Here we, by positron emission tomography, monitored tissue-specific blood flow (BF) changes in nine healthy young men during femoral arterial infusions of norepinephrine (NE) and phentolamine. At rest, the α-adrenoceptor agonist NE reduced BF by ~40%, similarly in muscles (from 3.2 ± 1.9 to 1.4 ± 0.3 ml·min(-1)·100 g(-1) in quadriceps femoris muscle), bone (from 1.1 ± 0.4 to 0.5 ± 0.2 ml·min(-1)·100 g(-1)) and adipose tissue (AT) (from 1.2 ± 0.7 to 0.7 ± 0.3 ml·min(-1)·100 g(-1)). During exercise, NE reduced exercising muscle BF by ~16%. BF in AT was reduced similarly as rest. The α-adrenoceptor antagonist phentolamine increased BF similarly in the different muscles and other tissues of the limb at rest. During exercise, BF in inactive muscle was increased 3.4-fold by phentolamine compared with exercise without drug, but BF in exercising muscles was not influenced. Bone and AT (P = 0.055) BF were also increased by phentolamine in the exercise condition. NE increased and phentolamine decreased oxygen extraction in the limb during exercise. We conclude that inhibition of α-adrenergic tone markedly disturbs the distribution of BF and oxygen extraction in the exercising human limb by increasing BF especially around inactive muscle fibers. Moreover, although marked functional sympatholysis also occurs during exercise, the arterial NE infusion that mimics the exaggerated sympathetic nerve activity commonly seen in patients with cardiovascular disease was still capable of directly limiting BF in the exercising leg muscles.

  11. Anomalous origin of right coronary artery from pulmonary artery

    Directory of Open Access Journals (Sweden)

    Rajat Gupta


    Full Text Available Anomalous origin of coronary artery from the pulmonary artery is a rare anomaly that most frequently involves the left coronary artery and very rarely the right coronary artery. These lesions can be missed on echocardiography unless carefully looked for. We describe a case of isolated anomalous origin of right coronary artery from pulmonary artery diagnosed on echocardiography and confirmed by computed tomography (CT angiography.

  12. Infant diet sets the tone for parasympathetic regulation of resting heart rate: Development of vagal tone from 3 months to 2 years (United States)

    The parasympathetic nervous system (PS) influences are critical in the autonomic control of the heart. To examine how early postnatal diet affects PS development, we used a measure of tonic PS control of cardiac activity, vagal tone, derived from resting heart rate recordings in 158 breastfed (BF), ...

  13. Split SR-RLS for the Joint Initialization of the Per-Tone Equalizers and Per-Tone Echo Cancelers in DMT-Based Receivers

    Directory of Open Access Journals (Sweden)

    Geert Ysebaert


    Full Text Available In asymmetric digital subscriber lines (ADSL, the available bandwidth is divided in subcarriers or tones which are assigned to the upstream and/or downstream transmission direction. To allow efficient bidirectional communication over one twisted pair, echo cancellation is required to separate upstream and downstream channels. In addition, intersymbol interference and intercarrier interference have to be reduced by means of equalization. In this paper, a computationally efficient algorithm for adaptively initializing the per-tone equalizers (PTEQ and per-tone echo cancelers (PTEC is presented. For a given number of equalizer and echo canceler taps per-tone, it was shown that the joint PTEQ/PTEC receiver structure is able to maximize the signal-to-noise ratio (SNR on each subcarrier and hence also the achievable bit rate. The proposed initialization scheme is based on a modification of the square root recursive least squares (SR-RLS algorithm to reduce computational complexity and memory requirement compared to full SR-RLS, while keeping the convergence rate acceptably fast. Our performance analysis will show that the proposed method converges in the mean and an upper bound for the step size is given. Moreover, we will indicate how the presented initialization method can be reused in several other ADSL applications.

  14. Functional Imaging of Human Vestibular Cortex Activity Elicited by Skull Tap and Auditory Tone Burst (United States)

    Noohi, Fatemeh; Kinnaird, Catherine; Wood, Scott; Bloomberg, Jacob; Mulavara, Ajitkumar; Seidler, Rachael


    The aim of the current study was to characterize the brain activation in response to two modes of vestibular stimulation: skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit saccular Vestibular Evoked Myogenic Potentials (VEMP) (Colebatch & Halmagyi 1992; Colebatch et al. 1994). Some researchers have reported that airconducted skull tap elicits both saccular and utricle VEMPs, while being faster and less irritating for the subjects (Curthoys et al. 2009, Wackym et al., 2012). However, it is not clear whether the skull tap and auditory tone burst elicit the same pattern of cortical activity. Both forms of stimulation target the otolith response, which provides a measurement of vestibular function independent from semicircular canals. This is of high importance for studying the vestibular disorders related to otolith deficits. Previous imaging studies have documented activity in the anterior and posterior insula, superior temporal gyrus, inferior parietal lobule, pre and post central gyri, inferior frontal gyrus, and the anterior cingulate cortex in response to different modes of vestibular stimulation (Bottini et al., 1994; Dieterich et al., 2003; Emri et al., 2003; Schlindwein et al., 2008; Janzen et al., 2008). Here we hypothesized that the skull tap elicits the similar pattern of cortical activity as the auditory tone burst. Subjects put on a set of MR compatible skull tappers and headphones inside the 3T GE scanner, while lying in supine position, with eyes closed. All subjects received both forms of the stimulation, however, the order of stimulation with auditory tone burst and air-conducted skull tap was counterbalanced across subjects. Pneumatically powered skull tappers were placed bilaterally on the cheekbones. The vibration of the cheekbone was transmitted to the vestibular cortex, resulting in vestibular response (Halmagyi et al., 1995). Auditory tone bursts were also delivered for comparison. To validate

  15. The Summary about Method of Marking Chinese Tone%汉语声调标调法述评

    Institute of Scientific and Technical Information of China (English)



    The method of marking tone has important values in the study of tone. The paper refers to five kinds of methods of marking tone. They are method of marking tone with symbols, method of marking tone with five degrees, method of marking tone with nine degrees, method of marking tone with dividing domains and four degrees, method of marking tone with tonal elements. Tone is characterized by sound-region features, arch features and postponing features. The above five methods respectively put emphasis on one or several features. At last we sum up the ideal principles of marking tone.%声调标调法在声调研究中具有重要的价值,其中符号标调法、五度标调法、九度标调法、分域四度制标调和调素标调法是五种比较重要的方法。根据声调所具有音区特征、曲拱特征和顺延特征,上述的五种标调法分别突出了其中的一种或几种特征。

  16. Production of Mandarin tones by 3-year-old children acquiring L1 (Mandarin) in an L2 (English) environment (United States)

    Wong, Puisan; Schwartz, Richard G.


    Thirteen monolingual Mandarin-speaking children residing in the U.S. were recruited to examine their production of the four Mandarin lexical tones in monosyllabic words. A picture-naming task was used to elicit the children's productions of lexical tones in isolated words and in sentence final position. Four mothers were asked to say the same set of words to their children in a picture reading activity. The children's and the mothers' productions were recorded and low-pass filtered at 500 and 400 Hz, respectively, to eliminate phonemic and semantic information. Ten Mandarin-speaking judges were recruited to identify the children's and adults' tone productions from the filtered stimuli. Contrary to the findings of L1 research conducted in countries where Mandarin is the language of the environment, the present results revealed that the lexical tones produced by 3-year-old children acquiring Mandarin as their first language in the U.S. were not yet adultlike. Children's tone productions were more difficult to categorize than the mothers' productions. The judges had significantly more difficulty identifying children's dipping tones than the children's level tones, rising tones, or falling tones, suggesting that the dipping tone posed the most difficulties for the children.

  17. Production of Mandarin tones by 3-year-old children acquiring L1 (Mandarin) in an L2 (English) environment (United States)

    Wong, Puisan; Schwartz, Richard G.


    Thirteen monolingual Mandarin-speaking children residing in the U.S. were recruited to examine their production of the four Mandarin lexical tones in monosyllabic words. A picture-naming task was used to elicit the children's productions of lexical tones in isolated words and in sentence final position. Four mothers were asked to say the same set of words to their children in a picture reading activity. The children's and the mothers' productions were recorded and low-pass filtered at 500 and 400 Hz, respectively, to eliminate phonemic and semantic information. Ten Mandarin-speaking judges were recruited to identify the children's and adults' tone productions from the filtered stimuli. Contrary to the findings of L1 research conducted in countries where Mandarin is the language of the environment, the present results revealed that the lexical tones produced by 3-year-old children acquiring Mandarin as their first language in the U.S. were not yet adultlike. Children's tone productions were more difficult to categorize than the mothers' productions. The judges had significantly more difficulty identifying children's dipping tones than the children's level tones, rising tones, or falling tones, suggesting that the dipping tone posed the most difficulties for the children.

  18. Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation

    Directory of Open Access Journals (Sweden)

    Davide Francomano


    vardenafil (0.6 ± 0.3 versus 4.5 ± 1.1 min, when compared with placebo. STAI-X1 and STAI-X2 scores fell within the normal range after treatment with vardenafil (. Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels.

  19. Arterial hypoxaemia in cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Hillingsø, Jens; Christensen, E


    BACKGROUND: Although low arterial oxygen tension (Po2) has been claimed to occur in one to two thirds of patients with cirrhosis, hypoxaemia appears to be rare in clinical practice. AIMS: To assess the frequency of arterial hypoxaemia in cirrhosis in relation to clinical and haemodynamic......%, 96%, 96%, and 93% (NS). So2 was below the lower limit of 92% in 0%, 9%, 7%, and 24% (p arterial carbon dioxide tension, a low systemic vascular...... resistance, and a low indocyanine green clearance (p arterial hypoxaemia in cirrhosis is about 22% in patients without encephalopathy, but it varies from 10-40% depending on the degree of hepatic dysfunction. Arterial hypoxaemia in patients with cirrhosis of differing...

  20. Artery by Neuropeptides

    Directory of Open Access Journals (Sweden)

    Esmeralda Sofia Costa Delgado


    Methods. Isolated rabbit eyes (n=12 were perfused in situ with tyrode through the external ophthalmic artery. Effects of intra-arterial injections of NPY 200 μg/ml (Group A; n=6 and VIP 200 μg/ml (Group B; n=6 on the recorded pressure were obtained. For statistical analysis, Student's paired t-test and Fast Fourier Transform were used. Results. Spontaneous oscillations were observed before any drug administration in the 12 rabbit models. NPY produced an increase in total vascular resistance and a higher frequency and amplitude of oscillations, while VIP evoked the opposite effects. Conclusions. This study provides evidence of vasomotion in basal conditions in rabbit external ophthalmic artery. Concerning drug effects, NPY increased arterial resistance and enhanced vasomotion while VIP produced opposite effects which demonstrates their profound influence in arterial vasomotion.

  1. [Transposition of Great Artery]. (United States)

    Konuma, Takeshi; Shimpo, Hideto


    Transposition of the great artery is one of common congenital cardiac disease resulting cyanosis. Death occurs easily in untreated patients with transposition and intact ventricular septal defect (VSD) in infancy at a few days of age when posterior descending coronary artery (PDA) closed. Since there are 2 parallel circulations, flow from pulmonary to systemic circulation is necessary for systemic oxygenation, and Balloon atrial septostomy or prostaglandin infusion should be performed especially if patient do not have VSD. Although the advent of fetal echocardiography, it is difficult to diagnose the transposition of the great arteries (TGA) as abnormality of great vessels is relatively undistinguishable. The diagnosis of transposition is in itself an indication for surgery, and arterial switch procedure is performed in the case the left ventricle pressure remains more than 2/3 of systemic pressure. Preoperative diagnosis is important as associated anomalies and coronary artery branching patterns are important to decide the operative indication and timing of surgery.

  2. Brain Plasticity in Speech Training in Native English Speakers Learning Mandarin Tones (United States)

    Heinzen, Christina Carolyn

    The current study employed behavioral and event-related potential (ERP) measures to investigate brain plasticity associated with second-language (L2) phonetic learning based on an adaptive computer training program. The program utilized the acoustic characteristics of Infant-Directed Speech (IDS) to train monolingual American English-speaking listeners to perceive Mandarin lexical tones. Behavioral identification and discrimination tasks were conducted using naturally recorded speech, carefully controlled synthetic speech, and non-speech control stimuli. The ERP experiments were conducted with selected synthetic speech stimuli in a passive listening oddball paradigm. Identical pre- and post- tests were administered on nine adult listeners, who completed two-to-three hours of perceptual training. The perceptual training sessions used pair-wise lexical tone identification, and progressed through seven levels of difficulty for each tone pair. The levels of difficulty included progression in speaker variability from one to four speakers and progression through four levels of acoustic exaggeration of duration, pitch range, and pitch contour. Behavioral results for the natural speech stimuli revealed significant training-induced improvement in identification of Tones 1, 3, and 4. Improvements in identification of Tone 4 generalized to novel stimuli as well. Additionally, comparison between discrimination of across-category and within-category stimulus pairs taken from a synthetic continuum revealed a training-induced shift toward more native-like categorical perception of the Mandarin lexical tones. Analysis of the Mismatch Negativity (MMN) responses in the ERP data revealed increased amplitude and decreased latency for pre-attentive processing of across-category discrimination as a result of training. There were also laterality changes in the MMN responses to the non-speech control stimuli, which could reflect reallocation of brain resources in processing pitch patterns

  3. The interaction of tone with voicing and foot structure: evidence from Kera phonetics and phonology (United States)

    Pearce, Mary Dorothy

    This thesis uses acoustic measurements as a basis for the phonological analysis of the interaction of tone with voicing and foot structure in Kera (a Chadic language). In both tone spreading and vowel harmony, the iambic foot acts as a domain for spreading. Further evidence for the foot comes from measurements of duration, intensity and vowel quality. Kera is unusual in combining a tone system with a partially independent metrical system based on iambs. In words containing more than one foot, the foot is the tone bearing unit (TBU), but in shorter words, the TBU is the syllable. In perception and production experiments, results show that Kera speakers, unlike English and French, use the fundamental frequency as the principle cue to 'Voicing" contrast. Voice onset time (VOT) has only a minor role. Historically, tones probably developed from voicing through a process of tonogenesis, but synchronically, the feature voice is no longer contrastive and VOT is used in an enhancing role. Some linguists have claimed that Kera is a key example for their controversial theory of long-distance voicing spread. But as voice is not part of Kera phonology, this thesis gives counter-evidence to the voice spreading claim. An important finding from the experiments is that the phonological grammars are different between village women, men moving to town and town men. These differences are attributed to French contact. The interaction between Kera tone and voicing and contact with French have produced changes from a 2-way voicing contrast, through a 3-way tonal contrast, to a 2-way voicing contrast plus another contrast with short VOT. These diachronic and synchronic tone/voicing facts are analysed using laryngeal features and Optimality Theory. This thesis provides a body of new data, detailed acoustic measurements, and an analysis incorporating current theoretical issues in phonology, which make it of interest to Africanists and theoreticians alike.

  4. Analysis of audio-vestibular assessment in acute low-tone hearing loss. (United States)

    Im, Gi Jung; Kim, Sung Kyun; Choi, June; Song, Jae Jun; Chae, Sung Won; Jung, Hak Hyun


    Conclusion This study demonstrated excellent hearing recovery following the combined treatment of diuretic and oral steroid, and electrocochleography (ECoG) was significantly higher than normal side. This study reports characteristics of acute low-tone hearing loss (ALHL) that show the greater low-tone hearing loss, the higher ECoG, and excellent recovery, even-though low-tone hearing loss is worse, which can be different compared with sudden deafness. Objective To analyze ALHL without vertigo, this study compared the ALHL group with all patients exhibiting low-tone hearing loss and ear fullness. Hearing changes and vestibular functions were analyzed. Materials and methods ALHL was defined as a mean hearing loss of ≥ 30 dB at 125, 250, and 500 Hz, and ≤ 20 dB at 2, 4, and 8 kHz. From 156 cases of low-tone hearing loss of more than 10 dB without vertigo, 31 met the ALHL criteria and were subjected to audio-vestibular assessments including PTA, ECoG, vestibular evoked myogenic potential (VEMP) testing, and caloric testing. Results In ALHL, low-tone hearing loss was 42.7 ± 9.5 dB, and 83.9% of ALHL significantly recovered by more than 10 dB. The ECoG in ALHL was 0.334 ± 0.11 (higher than 0.25 ± 0.08 on the normal side) and ECoG abnormality was 35.5% (the greater low-tone hearing loss, the higher ECoG value).

  5. Effects of Suprasegmental Phonological Alternations on Early Word Recognition: Evidence from Tone Sandhi. (United States)

    Wewalaarachchi, Thilanga D; Singh, Leher


    Early language acquisition is potentially complicated by the presence of many sources of variability in the speech signal. A frequent example of variability is phonological alternations, which can lead to context-driven changes in the realization of a word. The aim of the current study was to investigate effects of a highly frequent yet scarcely researched type of suprasegmental phonological alternation - tone Sandhi - on early spoken word recognition. The tone Sandhi rule investigated herein involves a tone change of the first syllable in a disyllabic unit. In accordance with third tone Sandhi, when two dipping tone syllables are juxtaposed in connected speech, the first syllable is dissimilated to a high rising tone. For example, 'flour mill' (unaltered pre-Sandhi form [(214) (214)]) undergoes tonal alternation resulting in the altered post-Sandhi form [(35) (214)]. In the current study, preschoolers' sensitivity to the effects of tone Sandhi when processing familiar words was investigated via a preferential looking paradigm. Words varied in their phonological form: one set of words was labeled with a phonological alternation due to Sandhi (Post Sandhi), one set of words was labeled with an unaltered Sandhi form (Pre Sandhi), one set consisted of non Sandhi words (Correct Pronunciation, and one set were labeled with a tonal alternation not associated with Sandhi rules (Mispronunciation). Post-Sandhi forms and correct pronunciations were associated with visual referents with comparable strength, with only a subtle processing cost observed for post-Sandhi forms in the time course of lexical selection. Likewise, pre-Sandhi forms and true mispronunciations were rejected as labels for visual references with comparable strength, with only subtle differences observed in the time course of lexical selection. Findings are discussed in terms of their impact on prevailing theories of lexical representation.

  6. Resting heart rate, vagal tone, and reactive and proactive aggression in Chinese children. (United States)

    Xu, Yiyuan; Raine, Adrian; Yu, Lidong; Krieg, Alexander


    Abundant research conducted in Western contexts has shown that biological risk factors such as low resting heart rate (HR) might be related to childhood aggression. However, it was unclear (1) how resting HR, as well as other markers of cardiac functions such as resting vagal tone, may be related to subtypes of aggression such as reactive and proactive aggression, and (2) whether the HR-aggression relation can be replicated in non-Western contexts. Therefore, this study examined the concurrent and prospective relations between resting HR, vagal tone, and Chinese children's reactive and proactive aggression. Participants were 183 children (M age=7.64 years, 91 girls) recruited from an elementary school in Zhenjiang, PRC. Children's resting HR and vagal tone were assessed in the second grade (T1). Teachers rated children's reactive and proactive aggression in the second (T1) and fourth grade (T2). Results showed that lower resting HR at T1 was associated with higher reactive and proactive aggression at T1 and T2, and higher vagal tone was associated with lower HR, which in turn was related to higher reactive and proactive aggression at T1 and T2. Lower vagal tone was directly related to higher reactive but not proactive aggression at T1 and T2, whereas lower HR was related to higher reactive aggression at T2 for children with low or moderate vagal tone but was not for children with high vagal tone. These psychophysiological findings from a non-Western context add additional support for both similarities and differences between reactive and proactive aggression in childhood.

  7. L’impact des biocarburants sur l’effet de serre

    Directory of Open Access Journals (Sweden)

    Poitrat Etienne


    Full Text Available Selon les statistiques de l’Observatoire de l’Énergie [1], la France a consommé 267 Mtep (tonnes équivalent pétrole d’énergie primaire en 2001, ou 269 Mtep avec correction climatique. Cette consommation comprend 145,6 Mtep sous forme d’énergie fossile (tableau 1. Les émissions corrigées du seul CO2 correspondant à l’énergie primaire consommée ont été entre août 2001 et juillet 2002, de 109 Mt de carbone par an [2]. Les énergies renouvelables (EnR totales utilisées en France sont d’environ 28 Mtep/an, dont 16,1 tep sont produits par les grands barrages hydro-électriques. Les autres EnR sont les bioénergies (11,9 Mtep/an et les énergies restantes, sont la géothermie, le solaire, l’éolien et la petite hydraulique [3]. En Europe, la France occupe la 5e place avec 11,5 % d’énergie renouvelable consommée après la Suède (26,7 %, l’Autriche (23,3 %, la Finlande (20,9 % et le Portugal (16,9 % [4]. D’autre part, la réserve mondiale prouvée des énergies fossiles représente au rythme actuel de consommation, qui est de 77 % de l’énergie totale consommée (tableau 2, environ 45 ans pour le pétrole, 60 ans pour le gaz et 220 à 250 ans pour le charbon. Afin de réduire les émissions de carbone fossile issues de la combustion des 77 % des énergies fossiles utilisées, il est nécessaire de réduire les consommations d’énergie par des économies et l’amélioration des rendements, de développer les énergies renouvelables et les technologies de séquestration du carbone. En France, les transports dépendent à plus de 95 % des hydrocarbures, non renouvelables, dont l’utilisation a une part déterminante (24 % dans l’émission des gaz à effet de serre. Le transport routier représente 81 % de la consommation énergétique du secteur. L’effet de serre se manifeste par un réchauffement de la température de l’air (+ 0,5 °C/100 ans et des océans (+ 0,3 °C/30 ans, avec une augmentation de la

  8. Use of paravascular admittance waveforms to monitor relative change in arterial blood pressure (United States)

    Zielinski, Todd M.; Hettrick, Doug; Cho, Yong


    Non-invasive methods to monitor ambulatory blood pressure often have limitations that can affect measurement accuracy and patient adherence [1]. Minimally invasive measurement of a relative blood pressure surrogate with an implantable device may provide a useful chronic diagnostic and monitoring tool. We assessed a technique that uses electrocardiogram and paravascular admittance waveform morphology analysis to one, measure a time duration (vascular tone index, VTI in milliseconds) change from the electrocardiogram R-wave to admittance waveform peak and two, measure the admittance waveform minimum, maximum and magnitude as indicators of change in arterial compliance/distensibility or pulse pressure secondary to change in afterload. Methods: Five anesthetized domestic pigs (32 ± 4.2 kg) were used to study the effects of phenylephrine (1-5 ug/kg/min) on femoral artery pressure and admittance waveform morphology measured with a quadrapolar electrode array catheter placed next to the femoral artery to assess the relative change in arterial compliance due to change in peripheral vascular tone. Results: Statistical difference was observed (p blood pressure may be suitable for implantable devices to detect progression of cardiovascular disease such as hypertension.



    Olivero, Bernard; Sbei Trabelsi, Nadia


    International audience; L'objectif de ce papier est d'analyser l'effet des impôts différés sur le contenu informationnel du résultat pour deux échantillons de firmes se référant aux normes IAS/IFRS et aux US GAAP sur une période de dix ans (1994-2003). En effet, c'est à partir de 1999 que le traitement selon les normes internationales (IAS 12 révisée) est le même que celui des US GAAP. Les tests réalisés permettent d'analyser l'effet de l'adoption de l'IAS 12 révisée sur le contenu informatio...

  10. L'effet des deformations plastiques severes sur les proprietes d'hydruration du magnesium (United States)

    Lang, Julien

    Le travail de recherche effectue durant mon projet de maitrise en physique a l'Universite du Quebec a Trois-Rivieres dans les laboratoires de l'Institut de Recherche sur l'Hydrogene etait de comparer l'effet du laminage a froid de la poudre de MgH2 avec celui du broyage mecanique. Nous avons etudie cette nouvelle technique en utilisant un laminoir vertical concu specialement pour laminer de la poudre. Nous avons lamine la poudre de MgH2 5, 25, 50 et 100 fois. La comparaison de la morphologie de la poudre de MgH 2 telle que recu du manufacturier et broye mecaniquement pendant 30 minutes avec celle de la poudre laminee ete faite a l'aide d'un microscope electronique a balayage. Nous avons par la suite mesure les proprietes de sorption d'hydrogene grace un appareil PCT de type Sievert. Nous avons aussi determine la structure cristalline par diffraction de rayons X. A partir de ces resultats, nous avons constate que le nombre optimal de laminages est de cinq et a les caracteristiques d'absorption/desorption d'hydrogene similaires a un broyage mecanique de 30 minutes. Nous avons aussi utilise les courbes de cinetiques d'absorption et de desorption d'hydrogene pour calculer l'etape limitative dans les reactions de sorption des echantillons lamines. Comme cinq laminages se font en environ 10 secondes, on voit que le laminage a froid est une technique plus interessante industriellement que le broyage mecanique a cause de l'important gain en temps et en energie.

  11. Les effets « santé » de l’huile d’olive

    Directory of Open Access Journals (Sweden)

    Saillard Morgane


    Full Text Available Les huiles d’olives bénéficient d’une forte image santé auprès des consommateurs. Pourtant il y a peu d’allégations nutritionnelles et de santé autorisées par la Commission pour ces huiles. On peut citer par exemple « riche en acides gras insaturés », « riche en vitamine E » ou des allégations plus élaborées telles que «Les polyphénols présents dans l’huile d’olive contribuent à protéger les lipides sanguins contre le stress oxydatif» ou « Le remplacement de graisses saturées par des graisses insaturées dans le régime alimentaire contribue au maintien d’une cholestérolémie normale ». D’autres effets santé bénéfiques ont pu être mis en évidence dans le régime méditerranéen grâce à certaines études : par exemple l’amélioration des fonctions cognitives (projet COGINUT ou des fonctions cardiovasculaires (étude PREDIMED, sans toutefois avoir d’allégations autorisées correspondantes. Des recherches supplémentaires sont nécessaires pour mieux comprendre le rôle de l’huile d’olive (et sa composition en acides gras et polyphénols dans ces fonctions.

  12. Les effets géographiques des éruptions volcaniques

    Directory of Open Access Journals (Sweden)

    Franck Lavigne


    Full Text Available Les méthodes de réflexion géographique permettent d’appréhender efficacement les jeux d’échelles et les temporalités multiples des effets induits par les éruptions volcaniques. L’objectif de cette synthèse est ainsi de comprendre les espaces volcaniques en tant qu’objets géographiques, en replaçant les impacts des éruptions au cœur d’une étude spatiale et temporelle. Les impacts de tels événements imposent des recompositions spatiales à l’échelle du volcan lui-même, et, dans le cas d’éruptions de plus grande magnitude, peuvent avoir des conséquences à l’échelle régionale voire mondiale. Les divers exemples abordés ici mettent l’accent sur les risques, la vulnérabilité et la résilience des populations vivant sur ces espaces marqués par les aléas volcaniques.The purpose of this paper aims to study the volcanic areas as geographical objects. Geographical analyses help to understand at different scales the levels of impacts induced by volcanic eruptions. Impacts of such events trigger spatial changes across the volcano itself, and can have consequences at regional or even global level in case of outbreaks of greater magnitude. The various examples discussed here focus on hazards, vulnerability and resilience of people living in those volcanic-hazard prone areas.

  13. The binaural masking-level difference of mandarin tone detection and the binaural intelligibility-level difference of mandarin tone recognition in the presence of speech-spectrum noise. (United States)

    Ho, Cheng-Yu; Li, Pei-Chun; Chiang, Yuan-Chuan; Young, Shuenn-Tsong; Chu, Woei-Chyn


    Binaural hearing involves using information relating to the differences between the signals that arrive at the two ears, and it can make it easier to detect and recognize signals in a noisy environment. This phenomenon of binaural hearing is quantified in laboratory studies as the binaural masking-level difference (BMLD). Mandarin is one of the most commonly used languages, but there are no publication values of BMLD or BILD based on Mandarin tones. Therefore, this study investigated the BMLD and BILD of Mandarin tones. The BMLDs of Mandarin tone detection were measured based on the detection threshold differences for the four tones of the voiced vowels /i/ (i.e., /i1/, /i2/, /i3/, and /i4/) and /u/ (i.e., /u1/, /u2/, /u3/, and /u4/) in the presence of speech-spectrum noise when presented interaurally in phase (S0N0) and interaurally in antiphase (SπN0). The BILDs of Mandarin tone recognition in speech-spectrum noise were determined as the differences in the target-to-masker ratio (TMR) required for 50% correct tone recognitions between the S0N0 and SπN0 conditions. The detection thresholds for the four tones of /i/ and /u/ differed significantly (pMandarin tones were all lower in the SπN0 condition than in the S0N0 condition, and the BMLDs ranged from 7.3 to 11.5 dB. The TMR for 50% correct Mandarin tone recognitions differed significantly (pMandarin tone detection and recognition in the presence of speech-spectrum noise are improved when phase inversion is applied to the target speech. The average BILDs of Mandarin tones are smaller than the average BMLDs of Mandarin tones.

  14. Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling. (United States)

    Retailleau, Kevin; Duprat, Fabrice; Arhatte, Malika; Ranade, Sanjeev Sumant; Peyronnet, Rémi; Martins, Joana Raquel; Jodar, Martine; Moro, Céline; Offermanns, Stefan; Feng, Yuanyi; Demolombe, Sophie; Patel, Amanda; Honoré, Eric


    The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling.

  15. Les effets des interfaces sur les proprietes magnetiques et de transport des multicouches nickel/iron et cobalt/silver (United States)

    Veres, Teodor

    Cette these est consacree a l'etude de l'evolution structurale des proprietes magnetiques et de transport des multicouches Ni/Fe et nanostructures a base de Co et de l'Ag. Dans une premiere partie, essentiellement bibliographique, nous introduisons quelques concepts de base relies aux proprietes magnetiques et de transport des multicouches metalliques. Ensuite, nous presentons une breve description des methodes d'analyse des resultats. La deuxieme partie est consacree a l'etude des proprietes magnetiques et de transport des multicouches ferromagnetiques/ferromagnetiques Ni/Fe. Nous montrerons qu'une interpretation coherente de ces proprietes necessite la prise en consideration des effets des interfaces. Nous nous attacherons a mettre en evidence, a evaluer et a etudier les effets de ces interfaces ainsi que leur evolution, et ce, suite a des traitements thermiques tel que le depot a temperature elevee et l'irradiation ionique. Les analyses correlees de la structure et de la magnetoresistance nous permettront d'emettre des conclusions sur l'influence des couches tampons entre l'interface et le substrat ainsi qu'entre les couches elles-memes sur le comportement magnetique des couches F/F. La troisieme partie est consacree aux systemes a Magneto-Resistance Geante (MRG) a base de Co et Ag. Nous allons etudier l'evolution de la microstructure suite a l'irradiation avec des ions Si+ ayant une energie de 1 MeV, ainsi que les effets de ces changements sur le comportement magnetique. Cette partie debutera par l'analyse des proprietes d'une multicouche hybride, intermediaire entre les multicouches et les materiaux granulaires. Nous analyserons a l'aide des mesures de diffraction, de relaxation superparamagnetique et de magnetoresistance, les evolutions structurales produites par l'irradiation ionique. Nous etablirons des modeles qui nous aideront a interpreter les resultats pour une serie des multicouches qui couvrent un large eventail de differents comportements magnetiques

  16. Effets du rationnement alimentaire chez le coq de type chair. Interactions avec la duree quotidienne d'eclairement


    De REVIERS, M.


    La tendance des coqs reproducteurs de type chair à prendre trop de poids à l’âge adulte doit être corrigée par le rationnement de l’aliment pour qu’ils puissent exprimer leur potentiel de reproduction et le faire dans des conditions économiques. Appliqué pendant la seule période adulte, ce rationnement ne permet que difficilement de corriger les effets d’un régime trop libéral pendant la croissance car il peut provoquer une diminution rapide et importante de la production des spermatozoïdes. ...

  17. Modeling tone and intonation in Mandarin and English as a process of target approximation. (United States)

    Prom-on, Santitham; Xu, Yi; Thipakorn, Bundit


    This paper reports the development of a quantitative target approximation (qTA) model for generating F(0) contours of speech. The qTA model simulates the production of tone and intonation as a process of syllable-synchronized sequential target approximation [Xu, Y. (2005). "Speech melody as articulatorily implemented communicative functions," Speech Commun. 46, 220-251]. It adopts a set of biomechanical and linguistic assumptions about the mechanisms of speech production. The communicative functions directly modeled are lexical tone in Mandarin and lexical stress in English and focus in both languages. The qTA model is evaluated by extracting function-specific model parameters from natural speech via supervised learning (automatic analysis by synthesis) and comparing the F(0) contours generated with the extracted parameters to those of natural utterances through numerical evaluation and perceptual testing. The F(0) contours generated by the qTA model with the learned parameters were very close to the natural contours in terms of root mean square error, rate of human identification of tone, and focus and judgment of naturalness by human listeners. The results demonstrate that the qTA model is both an effective tool for research on tone and intonation and a potentially effective system for automatic synthesis of tone and intonation.

  18. Visual comfort is affected by urban colorscape tones in hazy weather

    Directory of Open Access Journals (Sweden)

    Yang Liu


    Full Text Available People׳s visual perception and recognition of urban colorscape tones change significantly in hazy weather. A psychological experiment is conducted in this study to investigate visual comfort related to commercial and residential buildings. Visual observations are performed on the tones of an urban colorscape during hazy weather and air pollution in Harbin, China. Fifty-eight color samples selected through an orthogonal method are evaluated through a Likert scale by 30 subjects in a laboratory setting. Statistical analysis is performed with the maximal information coefficient and R language. Experimental results show that the changing threshold values of color tones are related to the visual comfort levels of the subjects. The influence of the three factors of color tones on visual comfort level is relatively independent, and the effects of value and chroma contrast on color comfort level are greater than that of hue contrast in hazy weather. Furthermore, the comfort recognition threshold values of color tones in hazy weather are determined through data comparisons and analyses.

  19. Perceptual and instrumental assessments of orofacial muscle tone in dysarthric and normal speakers

    Directory of Open Access Journals (Sweden)

    Angela M. Dietsch, PhD


    Full Text Available Clinical assessment of orofacial muscle tone is of interest for differential diagnosis of the dysarthrias, but standardized procedures and normative data are lacking. In this study, perceptual ratings of tone were compared with instrumental measures of tissue stiffness for facial, lingual, and masticatory muscles in 70 individuals with dysarthria. Perceptual and instrumental tone data were discordant and failed to discriminate between five dysarthria types. These results raised concerns about the validity of Myoton-3 stiffness measures in the orofacial muscles. Therefore, a second study evaluated contracted and relaxed orofacial muscles in 10 neurotypical adults. Results for the cheek, masseter, and lateral tongue surface followed predictions, with significantly higher tissue stiffness during contraction. In contradiction, stiffness measures from the superior surface of the tongue were lower during contraction. Superior-to-inferior tongue thickness was notably increased during contraction. A third study revealed that tissue thickness up to ~10 mm significantly affected Myoton-3 measures. Altered tissue thickness due to neuromuscular conditions like spasticity and atrophy may have undermined the detection of group differences in the original sample of dysarthric speakers. These experiments underscore the challenges of assessing orofacial muscle tone and identify considerations for quantification of tone-related differences across dysarthria groups in future studies.

  20. 中古入声字在开县话中的演变%Changes of Middle Classical Characters with Entering Tone in Kaixian County Dialect

    Institute of Scientific and Technical Information of China (English)



    开县话有阴平、阳平、上声、去声四个声调,没有入声,中古入声字今基本读阳平,极少数读去声、阴平,个别读上声。开县话没有入声韵,中古入声字今全读舒声韵。与普通话相比较,中古入声字在今开县话韵母中的分布自有其特点。%There are four tones in Kaixian County dialect: high level tone, rising tone, the falling-rising tone and falling tone, without entering tone. The medieval entering tones are read with rising tone, a little with falling tone and level tone and rising tones individually. Entering tone character is not included in Kaixian County dialect phonology, the level tone rhyme being read in the medieval entering tone characters. Compared with standard Chinese pronunciation, medieval entering tone characters has its particular characteristics in Kaixian County dialect distribution.

  1. L'effet de levier financier des entreprises : une comparaison entre le Canada et les E.-U., 1961-1996


    Zyblock, Miles


    Des etudes recentes ont montre que les compagnies dont le ratio emprunts/capitaux propres est relativement eleve manifestent une plus grande variabilite pour ce qui est des investissements et de la main-d'oeuvre. D'autres etudes maintiennent qu'un effet de levier financier eleve dans le monde des entreprises est associe a une instabilite macro-economique. Le present expose decrit et compare l'effet de levier financier global des entreprises au Canada et aux Etats-Unis de 1961 a 1996. Le levie...

  2. Coronary artery aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Koischwitz, D.; Harder, T.; Schuppan, U.; Thurn, P.


    Seven saccular coronary artery aneurysms have been demonstrated in the course of 1452 selective coronary artery angiograms. In six patients they were arterio-sclerotic; in one patient the aneurysm must have been congenital or of mycotic-embolic origin. The differential diagnosis between true aneurysms and other causes of vascular dilatation is discussed. Coronary artery aneurysms have a poor prognosis because of the possibility of rupture with resultant cardiac tamponade, or the development of thrombo-embolic myocardial infarction. These aneurysms can only be diagnosed by means of coronary angiography and require appropriate treatment.

  3. Coronary Artery Bypass

    Directory of Open Access Journals (Sweden)

    Kadri Ceberut


    Full Text Available Ancient schwannoma is a rare variant of neural tumors though rarely seen in the thorax. The combination with coronary artery diseases is also rare. Here we describe a 66 year-old male who had undergone one-stage combined surgery for thoracic ancient schwannomas removal and coronary artery disease. The masses were, respectively, 13 cm in the middle mediastinum and 5 cm in diameter originating from the intercostal nerve. The tumors were successfully removed using sternotomy, and then a coronary artery bypass grafting was performed. Here we discuss this rare tumor in relation to the relevant literature.

  4. Pure tone audiometry and impedance screening of school entrant children by nurses: evaluation in a practical setting.


    Holtby, I; Forster, D P; Kumar, U.


    BACKGROUND: Screening for hearing loss in English children at entry to school (age 5-6 years) is usually by pure tone audiometry sweep undertaken by school nurses. This study aimed to compare the validity and screening rates of pure tone audiometry with impedance screening in these children. METHODS: Two stage pure tone audiometry and impedance methods of screening were compared in 610 school entry children from 19 infant schools in north east England. Both procedures were completed by school...

  5. Mandarin-English Bilinguals Process Lexical Tones in Newly Learned Words in Accordance with the Language Context. (United States)

    Quam, Carolyn; Creel, Sarah C


    Previous research has mainly considered the impact of tone-language experience on ability to discriminate linguistic pitch, but proficient bilingual listening requires differential processing of sound variation in each language context. Here, we ask whether Mandarin-English bilinguals, for whom pitch indicates word distinctions in one language but not the other, can process pitch differently in a Mandarin context vs. an English context. Across three eye-tracked word-learning experiments, results indicated that tone-intonation bilinguals process tone in accordance with the language context. In Experiment 1, 51 Mandarin-English bilinguals and 26 English speakers without tone experience were taught Mandarin-compatible novel words with tones. Mandarin-English bilinguals out-performed English speakers, and, for bilinguals, overall accuracy was correlated with Mandarin dominance. Experiment 2 taught 24 Mandarin-English bilinguals and 25 English speakers novel words with Mandarin-like tones, but English-like phonemes and phonotactics. The Mandarin-dominance advantages observed in Experiment 1 disappeared when words were English-like. Experiment 3 contrasted Mandarin-like vs. English-like words in a within-subjects design, providing even stronger evidence that bilinguals can process tone language-specifically. Bilinguals (N = 58), regardless of language dominance, attended more to tone than English speakers without Mandarin experience (N = 28), but only when words were Mandarin-like-not when they were English-like. Mandarin-English bilinguals thus tailor tone processing to the within-word language context.

  6. Earlier timbre processing of instrumental tones compared to equally complex spectrally rotated sounds as revealed by the mismatch negativity. (United States)

    Christmann, Corinna A; Lachmann, Thomas; Berti, Stefan


    Harmonically rich sounds have been shown to be processed more efficiently by the human brain compared to single sinusoidal tones. To control for stimulus complexity as a potentially confounding factor, tones and equally complex spectrally rotated sounds, have been used in the present study to investigate the role of the overtone series in sensory auditory processing in non-musicians. Timbre differences in instrumental tones with equal pitch elicited a MMN which was earlier compared to that elicited by the spectrally rotated sounds, indicating that harmonically rich tones are processed faster compared to non-musical sounds without an overtone series, even when pitch is not the relevant information.

  7. Mandarin-English Bilinguals Process Lexical Tones in Newly Learned Words in Accordance with the Language Context (United States)

    Quam, Carolyn; Creel, Sarah C.


    Previous research has mainly considered the impact of tone-language experience on ability to discriminate linguistic pitch, but proficient bilingual listening requires differential processing of sound variation in each language context. Here, we ask whether Mandarin-English bilinguals, for whom pitch indicates word distinctions in one language but not the other, can process pitch differently in a Mandarin context vs. an English context. Across three eye-tracked word-learning experiments, results indicated that tone-intonation bilinguals process tone in accordance with the language context. In Experiment 1, 51 Mandarin-English bilinguals and 26 English speakers without tone experience were taught Mandarin-compatible novel words with tones. Mandarin-English bilinguals out-performed English speakers, and, for bilinguals, overall accuracy was correlated with Mandarin dominance. Experiment 2 taught 24 Mandarin-English bilinguals and 25 English speakers novel words with Mandarin-like tones, but English-like phonemes and phonotactics. The Mandarin-dominance advantages observed in Experiment 1 disappeared when words were English-like. Experiment 3 contrasted Mandarin-like vs. English-like words in a within-subjects design, providing even stronger evidence that bilinguals can process tone language-specifically. Bilinguals (N = 58), regardless of language dominance, attended more to tone than English speakers without Mandarin experience (N = 28), but only when words were Mandarin-like—not when they were English-like. Mandarin-English bilinguals thus tailor tone processing to the within-word language context. PMID:28076400

  8. The effect of L1 prosodic backgrounds of Cantonese and Japanese speakers on the perception of Mandarin tones after training (United States)

    So, Connie K.


    The present study investigated to what extent ones' L1 prosodic backgrounds affect their learning of a new tonal system. The question as to whether native speakers of a tone language perform differently from those of a pitch accent language will be addressed. Twenty native speakers of Hong Kong Cantonese (a tone language) and Japanese (a pitch accent language) were assigned to two groups. All of them had had no prior knowledge of Mandarin, and had never received any form of musical training before they participated in the study. Their performance of the identification of Mandarin tones before and after a short-term training was compared. Analysis of listeners' tonal confusions in the pretest, posttest, and generalization tests revealed that both Cantonese and Japanese listeners had more confusion for two contrastive tone pairs: Tone 1-Tone 4, and Tone 2-Tone 3. Moreover, Cantonese speakers consistently had greater difficulty than Japanese speakers in distinguishing the tones in each pair. These imply that listeners L1 prosodic backgrounds are at work during the process of learning a new tonal system. The findings will be further discussed in terms of the Perceptual Assimilation Model (Best, 1995). [Work supported by SSHRC.

  9. A tone-aided dual vestigial sideband system for digital communications on fading channels (United States)

    Hladik, Stephen M.; Saulnier, Gary J.; Rafferty, William


    A spectrally efficient tone-aided dual vestigial sideband (TA/DVSB) system for digital data communications on fading channels is presented and described analytically. This PSK (phase-shift-keying) system incorporates a feed-forward, tone-aided demodulation technique to compensate for Doppler frequency shift and channel- induced, multipath fading. In contrast to other tone-in-band-type systems, receiver synchronization is derived from the complete data VSBs. Simulation results for the Rician fading channel are presented. These results demonstrate the receiver's ability to mitigate performance degradation due to fading and to obtain proper data carrier synchronization, suggesting that the proposed TA/DVSB system has promise for this application. Simulated BER (bit-error rate) data indicate that the TA/DVSB system effectively alleviates the channel distortions of the land mobile satellite application.

  10. Problems in Mandarin Tone Acquisition by American Students--The Interference of American English Intonation Patterns

    Institute of Scientific and Technical Information of China (English)

    Ming Chao Gui


    It is intended in this paper to discuss the common patterns of American intonation that interfere the tone acquisition by American students. Similar to the linguistic phenomenon that nonnative speakers of English speak the language with foreign accent due to the influence and linguistic constraints of their own mother tongue, American students face interference from the intonation patterns of American English in their acquisition of tones in the study of Mandarin Chinese. The syntactic structure that most clearly reflects this fact is the two-syllable Chinese word groups. After a close study of the most common mistakes made by American students in .their study of Mandarin tones, some general patterns are observed. It is concluded that the major causes of these mistakes could be attributed to English intonation pattems on the same level of syntactic structure

  11. Lexical prosody beyond first-language boundary: Chinese lexical tone sensitivity predicts English reading comprehension. (United States)

    Choi, William; Tong, Xiuli; Cain, Kate


    This 1-year longitudinal study examined the role of Cantonese lexical tone sensitivity in predicting English reading comprehension and the pathways underlying their relation. Multiple measures of Cantonese lexical tone sensitivity, English lexical stress sensitivity, Cantonese segmental phonological awareness, general auditory sensitivity, English word reading, and English reading comprehension were administered to 133 Cantonese-English unbalanced bilingual second graders. Structural equation modeling analysis identified transfer of Cantonese lexical tone sensitivity to English reading comprehension. This transfer was realized through a direct pathway via English stress sensitivity and also an indirect pathway via English word reading. These results suggest that prosodic sensitivity is an important factor influencing English reading comprehension and that it needs to be incorporated into theoretical accounts of reading comprehension across languages.

  12. An Experiment for Generating the 14-Tone Stable Carriers Using Recirculating Frequency Shifter

    Institute of Scientific and Technical Information of China (English)

    TIAN Feng; ZHANG Xiao-Guang; LI Jian-Ping; XI Li-Xia


    @@ In experiment,the generation of 14-tone stable carriers with recirculating frequency shifter is realized.Some factors that impact the performance of the carrier generation are discussed.It is experimentally found that the balance and the insertion loss of the inphase/quadrature (l/Q,) modulator,the accurate π /2 phase difference and equal power level of two rf signals which are applied to the two ports of the I/Q modulator,the gain of the optical amplifier,the bandwidth and sharp window spectrum of the tunable filter and the stability of the optical signals' states of polarization fed into I/Q modulator,play important roles in the generation of a stable multi-tone carrier source.By employing appropriate techniques we obtain 14-tone stable carriers in the experiment.

  13. Speaking a tone language enhances musical pitch perception in 3-5-year-olds. (United States)

    Creel, Sarah C; Weng, Mengxing; Fu, Genyue; Heyman, Gail D; Lee, Kang


    Young children learn multiple cognitive skills concurrently (e.g., language and music). Evidence is limited as to whether and how learning in one domain affects that in another during early development. Here we assessed whether exposure to a tone language benefits musical pitch processing among 3-5-year-old children. More specifically, we compared the pitch perception of Chinese children who spoke a tone language (i.e., Mandarin) with English-speaking American children. We found that Mandarin-speaking children were more advanced at pitch processing than English-speaking children but both groups performed similarly on a control music task (timbre discrimination). The findings support the Pitch Generalization Hypothesis that tone languages drive attention to pitch in nonlinguistic contexts, and suggest that language learning benefits aspects of music perception in early development. A video abstract of this article can be viewed at:

  14. Impact of Rhythm on Vietnamese Adult EFL Learners Intelligibility in Term of Mid-level Tone

    Directory of Open Access Journals (Sweden)

    Tien DANG


    Full Text Available This study investigates the impact of L1 (Vietnamese on L2 (English with a specific reference to rhythm. The transfer of L1 rhythm to the L2 rhythm is considered as a potential factor in reducing EFL learner’s intelligibility.  The findings of this quantitative research show that Vietnamese adult EFL learners’ oral output is significantly unintelligible due to the application the mid-level tone of their first language, part of Vietnamese rhythm to produce English rhythm in a pronunciation test, making their utterance monotonous. This paper aims at presenting findings gained from an examination into how the Vietnamese rhythm, the mid-level tone, affects 50 Vietnamese adult EFL learners’ intelligibility in a pronunciation test assessed by ten judges. Key words: rhythm, mid-level tone, Vietnamese adult EFL learners, and intelligibility

  15. Modeling two-tone suppression and distortion product on basilar membrane (United States)

    Murakami, Yasuki; Ishimitsu, Shunsuke


    This paper reveals mechanisms of two-tone suppression (2TS) and distortion product (DP) on the basilar membrane (BM) using a model. Computational simulation is conducted with an active and nonlinear transmission line model including a nonlinear outer hair cell model that shows compressive property in two dimensionally where two tones are input. To evaluate the cochlear model, over all responses of BM model are used. For simultaneous input pairs, the response is suppressed by a stronger tone, or distorted where levels of a pair are equaled. Cubic distortion produced by a simple nonlinear feedback system including the OHC model appears similar to DPs in the cochlear model. These results suggest that two dimensional property of the OHC and its feedback generate 2TS and DPs. This further suggests the importance of the overall responses for investigating mechanisms of cochlear nonlinearities without fluid coupling in the cochlea.

  16. Tone model integration based on discriminative weight training for Putonghua speech recognition

    Institute of Scientific and Technical Information of China (English)

    HUANG Hao; ZHU Jie


    A discriminative framework of tone model integration in continuous speech recognition was proposed. The method uses model dependent weights to scale probabilities of the hidden Markov models based on spectral features and tone models based on tonal features.The weights are discriminatively trahined by minimum phone error criterion. Update equation of the model weights based on extended Baum-Welch algorithm is derived. Various schemes of model weight combination are evaluated and a smoothing technique is introduced to make training robust to over fitting. The proposed method is ewluated on tonal syllable output and character output speech recognition tasks. The experimental results show the proposed method has obtained 9.5% and 4.7% relative error reduction than global weight on the two tasks due to a better interpolation of the given models. This proves the effectiveness of discriminative trained model weights for tone model integration.

  17. Power constrained contrast enhancement based on brightness compensated contrast-tone mapping operation (United States)

    Jung, Cheolkon; Su, Haonan; Wang, Lu; Ke, Peng


    We propose power constrained contrast enhancement based on brightness compensated contrast-tone mapping operation (BCCTMO). We adopt brightness compensation to restore the original perceptual luminance and combine tone mapping with contrast enhancement to improve image quality. First, we increase pixel values to compensate for the reduced brightness caused by backlight dimming while maintaining the perceived luminance. Then we perform a contrast-tone mapping operation to reduce the information loss caused by the brightness compensation and enhance contrast in images. Finally, we conduct color scaling to reproduce natural colors. We implement BCCTMO on an Android tablet with an LCD display using mathematical approximation. Experimental results demonstrate that BCCTMO produces high-quality images while minimizing distortions and saving power compared with state-of-the-art methods.

  18. Data Compression for Video-Conferencing using Half tone and Wavelet Transform

    Directory of Open Access Journals (Sweden)

    Dr. H.B.Kekre


    Full Text Available Overhead of data transmission over internet is increasing exponentially every day. Optimization of natural bandwidth is the basic motive by compressing image data to the maximum extend. For the same objective, combination of lossy half tone and lossless Wavelet Transform techniques is proposed so as to obtain low-bit rate video data transmission. Decimal values of bitmapped image are to be converted into either 1 or 0 in half toning process that incur pictorial loss and gives 8:1 compression ratio (CR irrespective of image. Wavelet Transform is applied on half tone image for higher compression for various levels. An experimental result shows the higher CR, minimum Mean Square Error (MSE. Ten sample images of different people captured by Nikon camera are used for experimentation.All images are bitmap (.BMP 512 X 512 in size. The proposed technique can be used for video conferencing, storage of movies and CCTV footage etc.

  19. Contractile responses to rat urotensin II in resting and depolarized basilar arteries. (United States)

    Porras-González, Cristina; Ureña, Juan; Egea-Guerrero, Juan José; Gordillo-Escobar, Elena; Murillo-Cabezas, Francisco; González-Montelongo, María del Carmen; Muñoz-Sánchez, María Angeles


    The effects of human urotensin II (hUII) on the vascular tone of different animal species has been studied extensively. However, little has been reported on the vasoactive effects of rat urotensin (rUII) in murine models. The aim of the present study was to investigate the effects of rUII on vasoreactivity in rat basilar arteries. Basilar arteries from adult male Wistar rats (300-350 g) were isolated, cut in rings, and mounted on a small vessel myograph to measure isometric tension. rUII concentrations were studied in both resting and depolarized state. To remove endothelial nitric oxide effects from the rUII response, we treated selected arterial rings with Nω-nitro-L-arginine methyl ester (L-NAME). 10 μM rUII produced a potent vasoconstrictor response in rat basilar arteries with intact endothelium, while isometric forces remained unaffected in arterial rings treated with lower rUII concentrations. Although L-NAME did not have a significant effect on 10 μM rUII-evoked contraction, it slightly increased arterial ring contraction elicited by 1 μM rUII. In depolarized arteries, dose-dependent rUII increased depolarization-induced contractions. This effect was suppressed by L-NAME. Our results show that the rat basilar artery has a vasoconstrictor response to rUII. The most potent vasoconstrictor effect was produced by lower doses of rUII (0.1 and 1 μM) in depolarized arteries with intact endothelium. This effect could facilitate arterial vasospasm in vascular pathophysiological processes such as subarachnoid hemorrhage and hypertension, when sustained depolarization and L-type Ca(2+) channel activation are present.

  20. Renal arteries (image) (United States)

    A renal angiogram is a test used to examine the blood vessels of the kidneys. The test is performed ... main vessel of the pelvis, up to the renal artery that leads into the kidney. Contrast medium ...

  1. Coronary Artery Bypass Surgery (United States)

    ... t help, you may need coronary artery bypass surgery. The surgery creates a new path for blood to flow ... more than one bypass. The results of the surgery usually are excellent. Many people remain symptom-free ...

  2. Carotid Artery Disease (United States)

    ... make them more vulnerable to damage. Tobacco use. Nicotine can irritate the inner lining of your arteries. ... your physical and mental capabilities such as strength, memory and speech. After that, your doctor may recommend: ...

  3. Pulmonary Arterial Hypertension (United States)

    Pulmonary Arterial Hypertension What Is Pulmonary Hypertension? To understand pulmonary hypertension (PH) it helps to understand how blood ows throughout your body. While the heart is one organ, it ...

  4. Long-term relationships between cholinergic tone, synchronous bursting and synaptic remodeling.

    Directory of Open Access Journals (Sweden)

    Maya Kaufman

    Full Text Available Cholinergic neuromodulation plays key roles in the regulation of neuronal excitability, network activity, arousal, and behavior. On longer time scales, cholinergic systems play essential roles in cortical development, maturation, and plasticity. Presumably, these processes are associated with substantial synaptic remodeling, yet to date, long-term relationships between cholinergic tone and synaptic remodeling remain largely unknown. Here we used automated microscopy combined with multielectrode array recordings to study long-term relationships between cholinergic tone, excitatory synapse remodeling, and network activity characteristics in networks of cortical neurons grown on multielectrode array substrates. Experimental elevations of cholinergic tone led to the abrupt suppression of episodic synchronous bursting activity (but not of general activity, followed by a gradual growth of excitatory synapses over hours. Subsequent blockage of cholinergic receptors led to an immediate restoration of synchronous bursting and the gradual reversal of synaptic growth. Neither synaptic growth nor downsizing was governed by multiplicative scaling rules. Instead, these occurred in a subset of synapses, irrespective of initial synaptic size. Synaptic growth seemed to depend on intrinsic network activity, but not on the degree to which bursting was suppressed. Intriguingly, sustained elevations of cholinergic tone were associated with a gradual recovery of synchronous bursting but not with a reversal of synaptic growth. These findings show that cholinergic tone can strongly affect synaptic remodeling and synchronous bursting activity, but do not support a strict coupling between the two. Finally, the reemergence of synchronous bursting in the presence of elevated cholinergic tone indicates that the capacity of cholinergic neuromodulation to indefinitely suppress synchronous bursting might be inherently limited.

  5. The Siren's Song: Exploitation of Female Flight Tones to Passively Capture Male Aedes aegypti (Diptera: Culicidae). (United States)

    Johnson, Brian J; Ritchie, Scott A


    The need to capture male mosquitoes has intensified recently as a result of a number of male-based sterile insect technique (SIT) and population-modification programs focused on Aedes aegypti (L.) having initiated field releases. Here, we report the results of the successful exploitation of the attraction of male Ae. aegypti to female flight tones to enhance male collections in nonmechanical passive (nonbattery powered) Gravid Aedes Traps (GAT). Prior to field studies, male attraction to female flight tones of 484 and 560 Hz, as well as to a male flight tone of 715 Hz, were assessed in a series of controlled release-recapture and semifield trials. These trials determined that a pure tone of 484 Hz was significantly more attractive to free-flying males than the other flight tones and enabled their collection in sound-baited GATs (ca. 95% capture rate after 2 h; 484 Hz at 65 dB). In contrast, gravid females were unresponsive to male or female flight tones and were evenly distributed among sound-baited and control GATs. Importantly, under normal field conditions sound-baited GATs (484 Hz at 70 dB) captured significantly more male Ae. aegypti per 24-h trap interval (1.3 ± 0.37) than controls (0.2 ± 0.13). Overall, sound-bated GATs captured approximately twice as many Ae. aegypti (male and female; 3.0 ± 0.68 per interval, 30 total) than controls (1.5 ± 0.56 per interval, 15 total). These results reveal that sound-baited GATs are a simple and effective surveillance tool for Ae. aegypti that would allow current male-based SIT and population-modification programs to effectively monitor males in their target populations.

  6. Heritability of cilioretinal arteries

    DEFF Research Database (Denmark)

    Taarnhøj, Nina Charlotte; Munch, Inger C; Kyvik, Kirsten O;


    PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs...... environmental factors. CONCLUSIONS: The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors....

  7. Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity. (United States)

    Colton, Ilsley; Mandalà, Maurizio; Morton, Jude; Davidge, Sandra T; Osol, George


    This study investigated how vasoconstriction (tone), wall tension, smooth muscle activation, and vascular wall deformation influence resistance artery vasodilator reactivity. Resistance arteries, from two different regional circulations (splanchnic, uterine) and from pregnant and non-pregnant rats, were cannulated and pressurized, or mounted on a wire myograph under isometric conditions prior to being exposed to both endothelium-dependent (acetylcholine, ACh) and -independent (sodium nitroprusside, SNP) vasodilator agonists. A consistent pattern of reduced vasodilator sensitivity was noted as a function of extent of preconstriction for both agonists noted in pressurized arteries. A similar pattern regarding activation was noted in wire-mounted arteries in response to SNP but not ACh. Wall tension proved to be a major determinant of vascular smooth muscle vasodilator reactivity and its normalization reversed this pattern, as more constricted vessels were more sensitive to ACh relaxation without any change in SNP sensitivity, suggesting that endothelial deformation secondary to vasoconstriction augments its vasodilator output. To our knowledge, this is the first study to dissect out the complex interplay between biophysical forces impinging on VSM (pressure, wall tension), the ambient level of tone (vasoconstriction, smooth muscle cell activation), and consequences of cellular (particularly endothelial) deformation secondary to constriction in determining resistance artery vasodilatory reactivity.

  8. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T


    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  9. Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats

    DEFF Research Database (Denmark)

    Jepps, T A; Olesen, S P; Greenwood, I A


    and spontaneously hypertensive, heart failure-prone (SHHF) rats - a rat model of human metabolic syndrome. EXPERIMENTAL APPROACH: Quantitative PCR and immunohistochemistry were used to determine the expression of KCNQ isoforms in penile tissue. Isometric tension was measured in intracavernous arterial rings......BACKGROUND AND PURPOSE: KCNQ-encoded voltage-dependent potassium channels (Kv 7) are involved in the regulation of vascular tone. In this study we evaluated the influence of Kv 7 channel activation on smooth muscle relaxation in rat penile arteries and corpus cavernosum from normal...... and corpus cavernosum strips isolated from normal and SHHF rats. KEY RESULTS: Transcripts for KCNQ3, KCNQ4 and KCNQ5 were detected in penile arteries and corpus cavernosum. KCNQ1 was only found in corpus cavernosum. Immunofluorescence signals to Kv 7.4 and Kv 7.5 were found in penile arteries, penile veins...

  10. WPP, No. 108: The acoustic consequences of phonation and tone interactions in Jalapa Mazatec



    San Felipe Jalapa de Díaz (Jalapa) Mazatec is unusual in possessing a three-way phonation contrast and three-way level tone contrast independent of phonation. This study investigates the acoustics of how phonation and tone interact in this language, and how such interactions are maintained across variables like speaker sex, vowel timecourse, and presence of aspiration in the onset. Using a large number of words from the recordings of Mazatec made by Paul Kirk and Peter Ladefoged in the 1980s ...

  11. Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha. (United States)

    Brock, C; Brock, B; Aziz, Q; Møller, H J; Pfeiffer Jensen, M; Drewes, A M; Farmer, A D


    The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-α in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-α effect, which warrants further evaluation in larger controlled studies.

  12. Copper Induces Vasorelaxation and Antagonizes Noradrenaline -Induced Vasoconstriction in Rat Mesenteric Artery

    Directory of Open Access Journals (Sweden)

    Yu-Chun Wang


    Full Text Available Background/Aims: Copper is an essential trace element for normal cellular function and contributes to critical physiological or pathological processes. The aim of the study was to investigate the effects of copper on vascular tone of rat mesenteric artery and compare the effects of copper on noradrenaline (NA and high K+ induced vasoconstriction. Methods: The rat mesenteric arteries were isolated and the vessel tone was measured by using multi wire myograph system in vitro. Blood pressure of carotid artery in rabbits was measured by using physiological data acquisition and analysis system in vivo. Results: Copper dose-dependently blunted NA-induced vasoconstriction of rat mesenteric artery. Copper-induced vasorelaxation was inhibited when the vessels were pretreated with NG-nitro-L-arginine methyl ester (L-NAME. Copper did not blunt high K+-induced vasoconstriction. Copper preincubation inhibited NA-evoked vasoconstriction and the inhibition was not affected by the presence of L-NAME. Copper preincubation showed no effect on high K+-evoked vasoconstriction. Copper chelator diethyldithiocarbamate trihydrate (DTC antagonized the vasoactivity induced by copper in rat mesenteric artery. In vivo experiments showed that copper injection (iv significantly decreased blood pressure of rabbits and NA or DTC injection (iv did not rescue the copper-induced hypotension and animal death. Conclusion: Copper blunted NA but not high K+-induced vasoconstriction of rat mesenteric artery. The acute effect of copper on NA-induced vasoconstriction was depended on nitric oxide (NO, but the effect of copper pretreatment on NA-induced vasoconstriction was independed on NO, suggesting that copper affected NA-induced vasoconstriction by two distinct mechanisms.

  13. Histamine receptors in isolated bovine oviductal arteries. (United States)

    Martínez, A C; Novella, S; Raposo, R; Recio, P; Labadía, A; Costa, G; Garcia-Sacristán, A; Benedito, S


    The present in vitro study was designed to evaluate the effect of histamine on isolated rings of bovine oviductal artery and to characterize the histamine receptors involved in the histamine-induced response. Endothelial dependence of the response was also investigated. Cumulative addition of histamine and 2-pyridylethylamine (histamine H receptor agonist) induced a concentration-dependent relaxation in intact arterial segments precontracted with noradrenaline. The histamine H1 receptor antagonist mepyramine showed non-competitive antagonism in the histamine-induced concentration-response curve. However, when the response to histamine was evaluated in the presence of mepyramine and histamine H1 and H3 receptors were blocked, Schild analysis yielded a line with a slope of 1.10 and a pA2 value of 8.91, indicating simple competitive antagonism of mepyramine at histamine H1 receptor sites. The histamine H2 receptor agonist, dimaprit, caused marked dilatation only at high doses. Cimetidine, propranolol and mepyramine failed to inhibit this relaxant effect. In precontracted oviductal arteries, cimetidine did not modify the histamine-induced concentration-response curves. Combined treatment with histamine H1 and H2 receptor antagonists did not induce an additional displacement with respect to the isolated effect of mepyramine thus excluding activation of histamine H2 receptors. Histamine and (R)-alpha-methylhistamine, a selective histamine H3 receptor agonist, produced a moderate contractile effect on the resting tone of preparations. Pretreatment with the selective histamine H1 receptor antagonist decreased the (R)-alpha-methylhistamine response but increased the maximal relaxant effect and abolished the contractile effect of histamine, suggesting the presence of a limited population of contractile histamine H3 receptors. Removal of the endothelium or pretreatment with methylene blue produced a significant inhibition of the relaxant response to histamine. Remaining

  14. Significance of CaV3.2 T-type Ca2+ channels for pressure- and flow-dependent vasomotor responses in rat and mouse mesenteric small arteries

    DEFF Research Database (Denmark)

    Jensen, Lars Jørn; Björling, K.; Hansen, Pernille B. Lærkegaard

    We investigated the potential significance of CaV3.2 channels in the myogenic response (MR) and flow-mediated vasodilatation (FMVD). CaV3.2 channels were immunolocalized to EC and VSMC in rat and mouse small mesenteric arteries. The myogenic tone at pressures of 40-120 mmHg was significantly larg...

  15. A Tale of Two Features: Perception of Cantonese Lexical Tone and English Lexical Stress in Cantonese-English Bilinguals. (United States)

    Tong, Xiuli; Lee, Stephen Man Kit; Lee, Meg Mei Ling; Burnham, Denis


    This study investigated the similarities and differences in perception of Cantonese tones and English stress patterns by Cantonese-English bilingual children, adults, and English monolingual adults. All three groups were asked to discriminate pairs of syllables that minimally differed in either Cantonese tone or in English stress. Bilingual children's performance on tone perception was comparable to their performance on stress perception. By contrast, bilingual adults' performance on tone perception was lower than their performance on stress perception, and there was a similar pattern in English monolingual adults. Bilingual adults tended to perform better than English monolingual adults on both the tone and stress perception tests. A significant correlation between tone perception and stress perception performance was found in bilingual children but not in bilingual adults. All three groups showed lower accuracy in the high rising-low rising contrast than any of the other 14 Cantonese tone contrasts. The acoustic analyses revealed that average F0, F0 onset, and F0 major slope were the critical acoustic correlates of Cantonese tones, whereas multiple acoustic correlates were salient in English stress, including average F0, spectral balance, duration and intensity. We argue that participants' difficulty in perceiving high rising-low rising contrasts originated from the contrasts' similarities in F0 onset and average F0; indeed the difference between their major slopes was the only cue with which to distinguish them. Acoustic-perceptual correlation analyses showed that although the average F0 and F0 onset were associated with tone perception performance in all three groups, F0 major slope was only associated with tone perception in the bilingual adult group. These results support a dynamic interactive account of suprasegmental speech perception by emphasizing the positive prosodic transfer between Cantonese tone and English stress, and the role that level of

  16. Limits on Monolingualism? A comparison of monolingual and bilingual infants’ abilities to integrate lexical tone in novel word learning.

    Directory of Open Access Journals (Sweden)

    Leher eSingh


    Full Text Available To construct their first lexicon, infants must determine the relationship between native phonological variation and the meanings of words. This process is arguably more complex for bilingual learners who are often confronted with phonological conflict: phonological variation that is lexically relevant in one language may be lexically irrelevant in the other. In a series of four experiments, the present study investigated English-Mandarin bilingual infants’ abilities to negotiate phonological conflict introduced by learning both a tone and a non-tone language. In a novel word learning task, bilingual children were tested on their sensitivity to tone variation in English and Mandarin contexts. Their abilities to interpret tone variation in a language-dependent manner were compared to those of monolingual Mandarin learning infants. Results demonstrated that at 12 to 13 months, bilingual infants demonstrated the ability to bind tone to word meanings in Mandarin, but to disregard tone variation when learning new words in English. In contrast, monolingual learners of Mandarin did not show evidence of integrating tones into word meanings in Mandarin at the same age even though they were learning a tone language. However, a tone discrimination paradigm confirmed that monolingual Mandarin learning infants were able to tell these tones apart at 12 to 13 months under a different set of conditions. Later, at 17 to 18 months, monolingual Mandarin learners were able to bind tone variation to word meanings when learning new words. Our findings are discussed in terms of cognitive adaptations associated with bilingualism that may ease the negotiation of phonological conflict and facilitate precocious uptake of certain properties of each language.

  17. A Tale of Two Features: Perception of Cantonese Lexical Tone and English Lexical Stress in Cantonese-English Bilinguals.

    Directory of Open Access Journals (Sweden)

    Xiuli Tong

    Full Text Available This study investigated the similarities and differences in perception of Cantonese tones and English stress patterns by Cantonese-English bilingual children, adults, and English monolingual adults. All three groups were asked to discriminate pairs of syllables that minimally differed in either Cantonese tone or in English stress. Bilingual children's performance on tone perception was comparable to their performance on stress perception. By contrast, bilingual adults' performance on tone perception was lower than their performance on stress perception, and there was a similar pattern in English monolingual adults. Bilingual adults tended to perform better than English monolingual adults on both the tone and stress perception tests. A significant correlation between tone perception and stress perception performance was found in bilingual children but not in bilingual adults. All three groups showed lower accuracy in the high rising-low rising contrast than any of the other 14 Cantonese tone contrasts. The acoustic analyses revealed that average F0, F0 onset, and F0 major slope were the critical acoustic correlates of Cantonese tones, whereas multiple acoustic correlates were salient in English stress, including average F0, spectral balance, duration and intensity. We argue that participants' difficulty in perceiving high rising-low rising contrasts originated from the contrasts' similarities in F0 onset and average F0; indeed the difference between their major slopes was the only cue with which to distinguish them. Acoustic-perceptual correlation analyses showed that although the average F0 and F0 onset were associated with tone perception performance in all three groups, F0 major slope was only associated with tone perception in the bilingual adult group. These results support a dynamic interactive account of suprasegmental speech perception by emphasizing the positive prosodic transfer between Cantonese tone and English stress, and the role

  18. Coronary anomaly: the single coronary artery

    Institute of Scientific and Technical Information of China (English)

    QIN Xu-guang; XIONG Wei-guo; LU Chun-peng; GONG Cheng-jie; SHANG Li-hua


    @@ Single coronary artery (SCA), defined as an artery that arises from the arterial trunk and nourishes the entire myocardium, is rare. We report two cases of SCA, one is the right coronary artery (RCA) originating from the middle of left descending artery (LAD), and the other is the left main coronary artery (LMCA) arising from the proximal right coronary artery.

  19. Coronary Artery and Pulmonary Artery Fistula Originated from Significant Stenosis in the Left Anterior Descending Artery

    Directory of Open Access Journals (Sweden)

    Alper Sami Kunt


    Full Text Available Coronary artery fistula (CAF is defined as a rare anomalous connection between a coronary artery and a major vessel or a cardiac chamber. We report a case of a left anterior descending coronary (LAD stenosis and coronary artery fistula between the LAD coronary artery and the pulmonary artery (PA. CAF is often diagnosed by coronary angiogram. We describe our diagnostic approach and review the literature on the epidemiology, the pathophysiology, the diagnostic modalities, and the treatment options.

  20. Strength training reduces arterial blood pressure but not sympathetic neural activity in young normotensive subjects (United States)

    Carter, Jason R.; Ray, Chester A.; Downs, Emily M.; Cooke, William H.


    The effects of resistance training on arterial blood pressure and muscle sympathetic nerve activity (MSNA) at rest have not been established. Although endurance training is commonly recommended to lower arterial blood pressure, it is not known whether similar adaptations occur with resistance training. Therefore, we tested the hypothesis that whole body resistance training reduces arterial blood pressure at rest, with concomitant reductions in MSNA. Twelve young [21 +/- 0.3 (SE) yr] subjects underwent a program of whole body resistance training 3 days/wk for 8 wk. Resting arterial blood pressure (n = 12; automated sphygmomanometer) and MSNA (n = 8; peroneal nerve microneurography) were measured during a 5-min period of supine rest before and after exercise training. Thirteen additional young (21 +/- 0.8 yr) subjects served as controls. Resistance training significantly increased one-repetition maximum values in all trained muscle groups (P training did not affect MSNA or heart rate. Arterial blood pressures and MSNA were unchanged, but heart rate increased after 8 wk of relative inactivity for subjects in the control group (61 +/- 2 to 67 +/- 3 beats/min; P = 0.01). These results indicate that whole body resistance exercise training might decrease the risk for development of cardiovascular disease by lowering arterial blood pressure but that reductions of pressure are not coupled to resistance exercise-induced decreases of sympathetic tone.


    Directory of Open Access Journals (Sweden)



    Full Text Available AIMS AND OBJECTIVE Bilateral internal iliac artery ligation is a useful skill for the management of life-threatening post-partum hemorrhage. The procedure is not without risks and long-term complications. This study was conducted to ensure documentation and reporting of pregnancies following bilateral hypogastric artery ligation in cases of post-partum hemorrhage. We also aimed to compare the menstrual function and reproductive outcome after bilateral internal iliac artery ligation done for atonic post-partum haemorrhage. DESIGN Prospective Case Study. SETTING Department of Obstetrics and Gynaecology, Institute of Obstetrics and Gynaecology, Madras Medical College and Hospital, Chennai, Jan 2013 to March 2015. PARTICIPANTS Ten cases of bilateral internal iliac artery ligation were done for atonic post-partum hemorrhage. Main outcome measures: The primary outcome was assessed as the resumption of menstruation, regular cycles, and ability to conceive after surgery. Secondary outcome was incidence of intrauterine growth retardation and recurrent post-partum hemorrhage in subsequent pregnancies. RESULTS The mean duration of resumption of menstruation following internal iliac artery ligation was 3 months. Bilateral internal iliac artery ligation is preferred over unilateral ligation as the extensive collaterals from the contralateral side immediately fill the circulation. The cases of atonic post-partum hemorrhage may require B-Lynch sutures in addition to bilateral internal iliac artery ligation to regain tone. Successful pregnancy after bilateral internal iliac artery ligation occurred in three out of seven cases. In one case, there was intrauterine growth retardation in eighth month. The patient was admitted and closely monitored with Doppler scan. At 35 weeks of gestation, emergency lower segment caesarean section was done for absent diastolic flow. The preterm neonate was 2 kilograms. There was no post-partum hemorrhage in the subsequent

  2. Review of relationships between grey-tone co-occurrence, semivariance, and autocorrelation based image texture analysis approaches

    NARCIS (Netherlands)

    Sanden, van der J.J.; Hoekman, D.H.


    In the present paper we review relationships between commonly used statistical approaches to analysis of image texture. The approaches considered characterize image texture by means of the statistics of grey- tone co- occurrence contrast, grey- tone co- occurrence correlation, semivariance, and auto

  3. Control of pineal indole biosynthesis by changes in sympathetic tone caused by factors other than environmental lighting. (United States)

    Lynch, H. J.; Eng, J. P.; Wurtman, R. J.


    Description of experimental investigations showing that, in addition to environmental lighting, other manipulations known to modify sympathetic tone can also modify pineal indole biosynthesis. Comparable alterations in sympathetic tone that occur in response to activity or feeding cycles may be instrumental in generating the pineal rhythms that persist in the absence of light-dark cycle.

  4. Auditory Cortex is Important in the Extinction of Two Different Tone-Based Conditioned Fear Memories in Rats. (United States)

    Song, Eun Young; Boatman, Jeffrey A; Jung, Min Whan; Kim, Jeansok J


    Extensive fear extinction research is guided by the view that there are structures in the brain that develop inhibitory control over the expression of conditioned fear memories. While the medial prefrontal cortex has recently captured attention as the locus of plasticity essential for extinction of conditioned fear, the auditory cortex is another plausible cortical area involved in extinction learning since it is considered a sufficient conditioned stimulus (CS) pathway in tone fear conditioning. We examined the role of auditory cortex in extinction of auditory-based fear memories with a standard tone-on conditioning, wherein a tone CS predicted a footshock unconditioned stimulus (US), or a novel tone-off conditioning, in which the tone was continually present and the offset of the tone was the CS predicting the US. Rats with bilateral auditory cortex lesions were trained in either paradigm and subsequently trained in extinction to the CS. Auditory cortex lesions had no effect on acquisition but impaired extinction to both CSs. These findings indicate that the auditory cortex contributes to extinction of wide-ranging auditory fear memories, as evidenced by deficits in both tone-on CS and tone-off CS extinction training.

  5. Oh what a beautiful morning! The time of day effect on the tone and market impact of conference calls

    NARCIS (Netherlands)

    Chen, J.; Demers, E.; Lev, B.


    Using textual analysis software, we examine whether and how the tone of the question and answer ("Q&A") portion of earnings-related conference calls varies with the time of day. We find that the tone of the conversations between analysts and managers becomes significantly more negative as the day we

  6. Chinese tone and vowel processing exhibits distinctive temporal characteristics: an electrophysiological perspective from classical Chinese poem processing. (United States)

    Li, Weijun; Wang, Lin; Yang, Yufang


    Classical Chinese poems have strict regulations on the acoustic pattern of each syllable and are semantically meaningless. Using such poems, this study characterized the temporal order of tone and vowel processing using event-related potentials (ERPs). The target syllable of the poem was either correct or deviated from the correct syllable at tone, vowel or both levels. Vowel violation elicited a negative effect between 300 and 500 ms regardless of the tone correctness, while tone violation elicited a positive effect between 600 and 1000 ms. The results suggest that the vowel information was available earlier than the tone information. Moreover, there was an interaction between the effect of vowel and tone violations between 600 and 1000 ms, showing that the vowel violation produced a positive effect only when the tone was correct. This indicates that vowel and tone processing interacts in the later processing stage, which involves both error detection and reanalysis of the spoken input. Implications of the present results for models of speech perception are discussed.

  7. Habitual traffic noise at home reduces cardiac parasympathetic tone during sleep

    NARCIS (Netherlands)

    Graham, J.M.A.; Janssen, S.A.; Vos, H.; Miedema, H.M.E.


    The relationships between road and rail traffic noise with pre-ejection period (PEP) and with respiratory sinus arrhythmia (RSA) during sleep, as indices of cardiac sympathetic and parasympathetic nervous system tone, were investigated in the field (36 subjects, with 188 and 192 valid subject nights

  8. Reduced Pelvic Floor Muscle Tone Predisposes to Persistence of Lower Urinary Tract Symptoms after Puerperium

    Directory of Open Access Journals (Sweden)

    Chandana Bhat


    Full Text Available Pregnant primiparous women at term were enrolled in the study. ICIQ-FLUTS questionnaire was used to find out prevalence of LUTS. MOS was used to assess pelvic floor muscle strength. Women were followed up after 8–10 weeks of delivery to find out remission or persistence of these symptoms. We found that increased frequency of micturition was the most common (82% LUTS seen in primiparous women at term. More than half (51% of these women who complained of LUTS had a poor pelvic floor muscle tone (MOS grade 3. Out of those who had symptoms during pregnancy 11% remained symptomatic even after puerperium. Interestingly 61% of those with persistence of symptoms demonstrated a very poor pelvic floor muscle tone at term (MOS grade 2, while the remaining 39% also had a tone of only MOS grade 3. Thus women with LUTS during pregnancy should be screened for their pelvic floor muscle tone with simple MOS system which will help to predict the persistence of these symptoms later on. Women with a low score (three or less should be triaged for regular pelvic floor muscle exercises.

  9. Pre-attentive modulation of brain responses to tones in coloured-hearing synesthetes

    Directory of Open Access Journals (Sweden)

    Jäncke Lutz


    Full Text Available Abstract Background Coloured-hearing (CH synesthesia is a perceptual phenomenon in which an acoustic stimulus (the inducer initiates a concurrent colour perception (the concurrent. Individuals with CH synesthesia "see" colours when hearing tones, words, or music; this specific phenomenon suggesting a close relationship between auditory and visual representations. To date, it is still unknown whether the perception of colours is associated with a modulation of brain functions in the inducing brain area, namely in the auditory-related cortex and associated brain areas. In addition, there is an on-going debate as to whether attention to the inducer is necessarily required for eliciting a visual concurrent, or whether the latter can emerge in a pre-attentive fashion. Results By using the EEG technique in the context of a pre-attentive mismatch negativity (MMN paradigm, we show that the binding of tones and colours in CH synesthetes is associated with increased MMN amplitudes in response to deviant tones supposed to induce novel concurrent colour perceptions. Most notably, the increased MMN amplitudes we revealed in the CH synesthetes were associated with stronger intracerebral current densities originating from the auditory cortex, parietal cortex, and ventral visual areas. Conclusions The automatic binding of tones and colours in CH synesthetes is accompanied by an early pre-attentive process recruiting the auditory cortex, inferior and superior parietal lobules, as well as ventral occipital areas.

  10. Brillouin optical time-domain analyzer based on orthogonally-polarized four-tone probe wave. (United States)

    Hong, Xiaobin; Lin, Wenqiao; Yang, Zhisheng; Wang, Sheng; Wu, Jian


    The tolerance of the non-local effect in the BOTDA method using a dual-tone probe wave with fixed frequency separation is theoretically and experimentally investigated in this paper. The presented analysis points out that when the sensing fiber consists of two long fiber segments with large BFS difference (> 100 MHz), there will always be only one probe tone interacting with the pump pulse in the front fiber segment. Therefore, although the pulse distortion problem can still be overcome in this case, the conventional non-local effect would impose systematic error on the estimated BFS of the hotspot located at the end of the front fiber segment. For the purpose of avoiding the impact of non-local effect and eliminating the pump distortion problem simultaneously when using high probe power, a novel method based on a four-tone probe wave is proposed, in which the probe light consists of two pairs of orthogonally-polarized dual-tone probe waves with opposite frequency scanning direction. The experimental results demonstrate that the proposed method is capable of realizing 2 m spatial resolution over 104-km-long sensing fiber without the impact of non-local effect.

  11. The Low Pitch of High-Frequency Complex Tones Relies on Temporal Fine Structure Information

    DEFF Research Database (Denmark)

    Santurette, Sébastien; Dau, Torsten


    structure (TFS) cues has been a matter of debate. It is also controversial up to which frequency TFS information remains available, and to what extent envelope cues become dominant as frequency increases. Using a pitch-matching paradigm, this study investigated whether the pitch of transposed tones...


    Directory of Open Access Journals (Sweden)

    Siddharth Nirwan


    Full Text Available BACKGROUND : Chronic S uppurative O titis M edia (CSOM is an important cause of preventable hearing loss , particularly in the developing world. Tympanoplasty is a procedure to eradicate the disease in middle ear and to reconstruct hearing mechanism. Pure tone audiometry is an efficient , simple and economic tool to assess the level of postoperative hearing gain

  13. Physiology and Functioning: Parents' Vagal Tone, Emotion Socialization, and Children's Emotion Knowledge (United States)

    Perlman, Susan B.; Camras, Linda A.; Pelphrey, Kevin A.


    This study examined relationships among parents' physiological regulation, their emotion socialization behaviors, and their children's emotion knowledge. Parents' resting cardiac vagal tone was measured, and parents provided information regarding their socialization behaviors and family emotional expressiveness. Their 4- or 5-year-old children (N…

  14. Known-Groups and Concurrent Validity of the Mandarin Tone Identification Test (MTIT.

    Directory of Open Access Journals (Sweden)

    Shufeng Zhu

    Full Text Available The Mandarin Tone Identification Test (MTIT is a new test designed to assess the tone identification abilities of children with hearing impairment (HI. Evidence for reliability and sensitivity has been reported. The present study aimed to evaluate the known-groups and concurrent validity of the MTIT.The MTIT and Mandarin Pediatric Speech Intelligibility test (MPSI were administered in quiet and in noise conditions. The known-groups validity was evaluated by comparing the performance of the MTIT on children with two different levels of HI. The MPSI was included to evaluate the concurrent validity of the MTIT.81 children with HI were recruited in the present study. They were Mandarin-speaking children with profound HI (mean age = 9; 0, n = 41 and with moderate to severe HI (mean age = 8; 9, n = 40.Scores on the MTIT differed between the two groups with different hearing levels suggesting good known-groups validity. A strong relationship between tone and sentence perception both in quiet and in noise provided preliminary evidence for concurrent validity.The present study confirmed that the MTIT has good known-groups validity and provided preliminary evidence for concurrent validity. The MTIT could be used to evaluate tone identification ability in children with HI with confidence.

  15. Discrimination of Tone Contrasts in Mandarin Disyllables by Naive American English Listeners (United States)

    Berkowitz, Shari Salzhauer


    The present study examined the perception of Mandarin disyllabic tones by inexperienced American English speakers. Participants heard two naturally-produced Mandarin disyllables, and indicated if the two were the same or different. A small native Mandarin-speaking control group participated as well. All 21 possible Mandarin contrasts where the…

  16. Mismatch Responses to Lexical Tone, Initial Consonant, and Vowel in Mandarin-Speaking Preschoolers (United States)

    Lee, Chia-Ying; Yen, Huei-ling; Yeh, Pei-wen; Lin, Wan-Hsuan; Cheng, Ying-Ying; Tzeng, Yu-Lin; Wu, Hsin-Chi


    The present study investigates how age, phonological saliency, and deviance size affect the presence of mismatch negativity (MMN) and positive mismatch response (P-MMR). This work measured the auditory mismatch responses to Mandarin lexical tones, initial consonants, and vowels in 4- to 6-year-old preschoolers using the multiple-deviant oddball…

  17. Communicative Focus on Form and Second Language Suprasegmental Learning: Teaching Cantonese Learners to Perceive Mandarin Tones (United States)

    Saito, Kazuya; Wu, Xianghua


    The current study examined how form-focused instruction (FFI) with and without corrective feedback (CF) as output enhancement facilitated second language (L2) perception of Mandarin tones at both the phonetic and phonological levels by 41 Cantonese learners of Mandarin. Two experimental groups, FFI only and FFI-CF, received a 90-min FFI treatment…

  18. Effects of Focus of Attention on Tone Production in Trained Singers (United States)

    Atkins, Rebecca L.


    Motor performance in familiar tasks is often advantaged when performers focus on the effects of their movements rather than on the movements themselves. But, this phenomenon has yet to be studied systematically in the context of vocal production. I evaluated 20 trained singers' vocal tone as they varied their focus of attention. Each participant…

  19. Skin Tone, Racism, Locus of Control, Hostility, and Blood Pressure in Hispanic College Students (United States)

    Trevino, Brandy; Ernst, Frederick A.


    There is some evidence that blood pressure is higher in persons with darker skin tone but the reasons for this remain unclear. When seen in minorities, the positive relationship between darkness of skin and blood pressure invites hypotheses about potential mediators of the relationship. We investigated the relationship in Hispanics of primarily…

  20. The impact of tone language and non-native language listening on measuring speech quality

    NARCIS (Netherlands)

    Ebem, D.U.; Beerends, J.G.; Vugt, J. van; Schmidmer, C.; Kooij, R.E.; Uguru, J.O.


    The extent to which the modeling used in objective speech quality algorithms depends on the cultural background of listeners as well as on the language characteristics using American English and Igbo, an African tone language is investigated. Two different approaches were used in order to separate b

  1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (United States)

    Miller, Bradley; Palygin, Oleg; Rufanova, Victoriya A; Chong, Andrew; Lazar, Jozef; Jacob, Howard J; Mattson, David; Roman, Richard J; Williams, Jan M; Cowley, Allen W; Geurts, Aron M; Staruschenko, Alexander; Imig, John D; Sorokin, Andrey


    Renal preglomerular arterioles regulate vascular tone to ensure a large pressure gradient over short distances, a function that is extremely important for maintaining renal microcirculation. Regulation of renal microvascular tone is impaired in salt-sensitive (SS) hypertension-induced nephropathy, but the molecular mechanisms contributing to this impairment remain elusive. Here, we assessed the contribution of the SH2 adaptor protein p66Shc (encoded by Shc1) in regulating renal vascular tone and the development of renal vascular dysfunction associated with hypertension-induced nephropathy. We generated a panel of mutant rat strains in which specific modifications of Shc1 were introduced into the Dahl SS rats. In SS rats, overexpression of p66Shc was linked to increased renal damage. Conversely, deletion of p66Shc from these rats restored the myogenic responsiveness of renal preglomerular arterioles ex vivo and promoted cellular contraction in primary vascular smooth muscle cells (SMCs) that were isolated from renal vessels. In primary SMCs, p66Shc restricted the activation of transient receptor potential cation channels to attenuate cytosolic Ca2+ influx, implicating a mechanism by which overexpression of p66Shc impairs renal vascular reactivity. These results establish the adaptor protein p66Shc as a regulator of renal vascular tone and a driver of impaired renal vascular function in hypertension-induced nephropathy.

  2. Masking of short probe sounds by tone bursts with a sweeping frequency

    NARCIS (Netherlands)

    Smoorenburg, G.F.; Coninx, F.


    The maske threshold of short (≤ 40 ms) probe tone or a short one-third octave probe noise appears to increase if the frequency of a tonal masker is swept. Frequency sweeps were exponential (octaves/s) and unidirectional. Probe sounds were presented in the time center of the masker at the center freq

  3. Measurement of effects on tone with lip-protecting music splints for wind instrument players (United States)

    Katada, Chigusa; Nozaki, Kazunori; Imai, Miharu; Kawamoto, Masayuki; Shima, Yuko; Tamagawa, Hiroo; Maeda, Yoshinobu; Ohboshi, Naoki; Toda, Tadao


    To protect against lip trauma from wind instruments, music splints that cover the sharp edges of incisor teeth are often manufactured by dentists. Wind instrument players who have installed these custom-made music splints often express not only their lip comfort but also changes in their tone quality. In this study, we investigated the effect of the splints to the tone quality. We recorded three types of trumpet sounds such as long tones, arpeggios with perfect fifth, and tonguing tones with and without using a splint, respectively, by a professional trumpet player in an anechoic room. After fast Fourier transform, the higher harmonics was observed more in the splint group than in the nonsplint group, with sharp peaks from 5000 to 8000 Hz. We also examined the differences of these sound groups with recognition tests by two groups of listeners such as professional musicians and nonprofessional persons. Though sound-pressure levels of higher harmonics in two sound groups were lower than those at 400 to 2000 Hz, the musically trained persons recognized the difference perfectly. These results suggest the target of measurement to evaluate the effect of music splints.

  4. Correlation coefficient measurement of the mode-locked laser tones using four-wave mixing. (United States)

    Anthur, Aravind P; Panapakkam, Vivek; Vujicic, Vidak; Merghem, Kamel; Lelarge, Francois; Ramdane, Abderrahim; Barry, Liam P


    We use four-wave mixing to measure the correlation coefficient of comb tones in a quantum-dash mode-locked laser under passive and active locked regimes. We study the uncertainty in the measurement of the correlation coefficient of the proposed method.

  5. Phonetic Influences on English and French Listeners' Assimilation of Mandarin Tones to Native Prosodic Categories (United States)

    So, Connie K.; Best, Catherine T.


    This study examined how native speakers of Australian English and French, nontone languages with different lexical stress properties, perceived Mandarin tones in a sentence environment according to their native sentence intonation categories (i-Categories) in connected speech. Results showed that both English and French speakers categorized…

  6. 47 CFR 73.4275 - Tone clusters; audio attention-getting devices. (United States)


    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Tone clusters; audio attention-getting devices. 73.4275 Section 73.4275 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST... clusters; audio attention-getting devices. See Public Notice, FCC 76-610, dated July 2, 1976. 60 FCC 2d...

  7. Dynamics of pure tone audiometry and DPOAE changes induced by glycerol in Meniere's disease. (United States)

    Jablonka-Strom, Agnieszka; Pospiech, Lucyna; Zatonski, Maciej; Bochnia, Marek


    The purpose of this study is to follow up the dynamics of pure tone threshold and DPOAE amplitude changes induced by glycerol with reference to its activity in the inner ear. Selection was made among 38 patients with Meniere's disease for those having positive glycerol test. Pure-tone audiometry and DP-gram were performed in four series: as an initial examination before glycerol intake, 1, 2 and 3 h after. Audiometric changes formed distinct biphasal pattern at all frequencies between 250 and 4,000 Hz. The most dynamic pure tone threshold decrease occurred during the first hour. Between the first and second hour after glycerol ingestion there was a phase of no significant hearing changes. Further pure tone threshold decrease went on within the third hour reaching its top. Observing DPOAE changes, the highest DP amplitude growth occurred after the second and the third hour at DP-gram frequencies 2, 3 and 4 kHz. The fastest DP-amplitude increase was registered as well during the first hour after glycerol ingestion. In 11 persons with both audiometry and DPOAE positive glycerol test, parallel dynamics in the course of the glycerol test was observed. Biphasal glycerol test dynamics suggests the possibility of two mechanisms of glycerol activity in the inner ear.

  8. An Empirical Study on the Acquisition of English Rising Tone by Chinese EFL Learners (United States)

    Chen, Wenkai


    Intonation is the melody and soul of speech, and plays an important role in oral communication. Nevertheless, the acquisition of English intonation by Chinese EFL learners is far from being satisfactory. It is found by empirical study that the main problems existing in acquiring English rising tone are improper placement of nucleus stress, failure…

  9. Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha

    DEFF Research Database (Denmark)

    Brock, C; Brock, B; Aziz, Q


    The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t...

  10. Cues for Lexical Tone Perception in Children: Acoustic Correlates and Phonetic Context Effects (United States)

    Tong, Xiuli; McBride, Catherine; Burnham, Denis


    Purpose: The authors investigated the effects of acoustic cues (i.e., pitch height, pitch contour, and pitch onset and offset) and phonetic context cues (i.e., syllable onsets and rimes) on lexical tone perception in Cantonese-speaking children. Method: Eight minimum pairs of tonal contrasts were presented in either an identical phonetic context…

  11. Lexical Encoding of L2 Tones: The Role of L1 Stress, Pitch Accent and Intonation (United States)

    Braun, Bettina; Galts, Tobias; Kabak, Baris


    Native language prosodic structure is known to modulate the processing of non-native suprasegmental information. It has been shown that native speakers of French, a language without lexical stress, have difficulties storing non-native stress contrasts. We investigated whether the ability to store lexical tone (as in Mandarin Chinese) also depends…

  12. Asymmetries in the perception of Mandarin tones: Evidence from mismatch negativity. (United States)

    Politzer-Ahles, Stephen; Schluter, Kevin; Wu, Kefei; Almeida, Diogo


    Most investigations of the representation and processing of speech sounds focus on their segmental representations, and considerably less is known about the representation of suprasegmental phenomena (e.g., Mandarin tones). Here we examine the mismatch negativity (MMN) response to the contrast between Mandarin Tone 3 (T3) and other tones using a passive oddball paradigm. Because the MMN response has been shown to be sensitive to the featural contents of speech sounds in a way that is compatible with underspecification theories of phonological representations, here, we test the predictions of such theories regarding suprasegmental phenomena. Assuming T3 to be underspecified in Mandarin (because it has variable surface representations and low pitch), we predicted that an asymmetric MMN response would be elicited when T3 is contrasted with another tone. In 2 of our 3 experiments, this was observed, but in non-Mandarin-speaking participants as well as native speakers, suggesting that the locus of the effect was perceptual (acoustic or phonetic) rather than phonological. In a third experiment, the predicted asymmetry was limited to native speakers. These results highlight the importance of distinguishing phonological and perceptual contributions to MMN asymmetries, but also demonstrate a role of abstract phonological representations in which certain information is underspecified in long-term memory.

  13. Time and frequency characteristics of temporary threshold shifts caused by pure tone exposures

    DEFF Research Database (Denmark)

    Ordoñez, Rodrigo Pizarro; Hammershøi, Dorte


    The time-frequency characteristics of Temporary Threshold Shifts (TTS) caused by pure tones were determined using the Békésy audiometric method with narrow-band noise of short duration as the probe stimuli. Two experiments were done using exposures of 3 min at 100 dB above threshold. In the first...

  14. High phase noise tolerant pilot-tone-aided DP-QPSK optical communication systems

    DEFF Research Database (Denmark)

    Zhang, Xu; Pang, Xiaodan; Deng, Lei


    In this paper we experimentally demonstrate a novel, high phase-noise tolerant, optical dual polarization (DP) quadrature phase-shift keying (QPSK) communication system based on pilot-tone-aided phase noise cancellation (PNC) algorithm. Vertical cavity surface emitting lasers (VCSELs...

  15. Auditory Pattern Recognition and Brief Tone Discrimination of Children with Reading Disorders (United States)

    Walker, Marianna M.; Givens, Gregg D.; Cranford, Jerry L.; Holbert, Don; Walker, Letitia


    Auditory pattern recognition skills in children with reading disorders were investigated using perceptual tests involving discrimination of frequency and duration tonal patterns. A behavioral test battery involving recognition of the pattern of presentation of tone triads was used in which individual components differed in either frequency or…

  16. Effect of Intensive Voice Treatment on Tone-Language Speakers with Parkinson's Disease (United States)

    Whitehill, Tara L.; Wong, Lina L. -N.


    The aim of this study was to investigate the effect of intensive voice therapy on Cantonese speakers with Parkinson's disease. The effect of the treatment on lexical tone was of particular interest. Four Cantonese speakers with idiopathic Parkinson's disease received treatment based on the principles of Lee Silverman Voice Treatment (LSVT).…

  17. Functional Imaging of Human Vestibular Cortex Activity Elicited by Skull Tap and Auditory Tone Burst (United States)

    Noohi, F.; Kinnaird, C.; Wood, S.; Bloomberg, J.; Mulavara, A.; Seidler, R.


    The current study characterizes brain activation in response to two modes of vestibular stimulation: skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit either the vestibulo-spinal reflex (saccular-mediated colic Vestibular Evoked Myogenic Potentials (cVEMP)), or the ocular muscle response (utricle-mediated ocular VEMP (oVEMP)). Some researchers have reported that air-conducted skull tap elicits both saccular and utricle-mediated VEMPs, while being faster and less irritating for the subjects. However, it is not clear whether the skull tap and auditory tone burst elicit the same pattern of cortical activity. Both forms of stimulation target the otolith response, which provides a measurement of vestibular function independent from semicircular canals. This is of high importance for studying otolith-specific deficits, including gait and balance problems that astronauts experience upon returning to earth. Previous imaging studies have documented activity in the anterior and posterior insula, superior temporal gyrus, inferior parietal lobule, inferior frontal gyrus, and the anterior cingulate cortex in response to different modes of vestibular stimulation. Here we hypothesized that skull taps elicit similar patterns of cortical activity as the auditory tone bursts, and previous vestibular imaging studies. Subjects wore bilateral MR compatible skull tappers and headphones inside the 3T GE scanner, while lying in the supine position, with eyes closed. Subjects received both forms of the stimulation in a counterbalanced fashion. Pneumatically powered skull tappers were placed bilaterally on the cheekbones. The vibration of the cheekbone was transmitted to the vestibular system, resulting in the vestibular cortical response. Auditory tone bursts were also delivered for comparison. To validate our stimulation method, we measured the ocular VEMP outside of the scanner. This measurement showed that both skull tap and auditory

  18. Heme oxygenase-1 upregulation modulates tone and fibroelastic properties of internal anal sphincter. (United States)

    Krishna, Chadalavada Vijay; Singh, Jagmohan; Kumar, Sumit; Rattan, Satish


    A compromise in the internal anal sphincter (IAS) tone and fibroelastic properties (FEP) plays an important role in rectoanal incontinence. Herein, we examined the effects of heme oxygenase (HO)-1 upregulation on these IAS characteristics in young rats. We determined the effect of HO-1 upregulator hemin on HO-1 mRNA and protein expressions and on basal IAS tone and its FEP before and after HO-1 inhibitor tin protoporphyrin IX. For FEP, we determined the kinetics of the IAS smooth muscle responses, by the velocities of relaxation, and recovery of the IAS tone following 0 Ca(2+) and electrical field stimulation. To characterize the underlying signal transduction for these changes, we determined the effects of hemin on RhoA-associated kinase (RhoA)/Rho kinase (ROCK) II, myosin-binding subunit of myosin light chain phosphatase 1, fibronectin, and elastin expression levels. Hemin increased HO-1 mRNA and protein similar to the increases in the basal tone, and in the FEP of the IAS. Underlying mechanisms in the IAS characteristics are associated with increases in the genetic and translational expressions of RhoA/ROCKII, and elastin. Fibronectin expression levels on the other hand were found to be decreased following HO-1 upregulation. The results of our study show that the hemin/HO-1 system regulates the tone and FEP of IAS. The hemin/HO-1 system thus provides a potential target for the development of new interventions aimed at treatment of gastrointestinal motility disorders, specifically the age-related IAS dysfunction.

  19. The derived allele of ASPM is associated with lexical tone perception.

    Directory of Open Access Journals (Sweden)

    Patrick C M Wong

    Full Text Available The ASPM and MCPH1 genes have been implicated in the adaptive evolution of the human brain [Mekel-Bobrov N. et al., 2005. Ongoing adaptive evolution of ASPM, a brain size determinant in homo sapiens. Science 309; Evans P.D. et al., 2005. Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science 309]. Curiously, experimental attempts have failed to connect the implicated SNPs in these genes with higher-level brain functions. These results stand in contrast with a population-level study linking the population frequency of their alleles with the tendency to use lexical tones in a language [Dediu D., Ladd D.R., 2007. Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and microcephalin. Proc. Natl. Acad. Sci. U.S.A. 104]. In the present study, we found a significant correlation between the load of the derived alleles of ASPM and tone perception in a group of European Americans who did not speak a tone language. Moreover, preliminary results showed a significant correlation between ASPM load and hemodynamic responses to lexical tones in the auditory cortex, and such correlation remained after phonemic awareness, auditory working memory, and non-verbal IQ were controlled. As in previous studies, no significant correlation between ASPM and cognitive measures were found. MCPH1 did not correlate with any measures. These results suggest that the association between the recently derived allele of ASPM is likely to be specific and is tied to higher level brain functions in the temporal cortex related to human communication.

  20. Left Coronary Artery-Pulmonary Artery Fistula in Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Orhan Veli Doğan


    Full Text Available Coroner artery fistula which is rare and congenital or acquired arise from whole coroner artery drainage all of cardiac chamber and great artery. Although coroner artery fistula is uncommon, it can cause significant mortality and morbidity rates. The article is presented which coroner artery disease and coroner-pulmonary artery fistula was accomplishment committed. Sixty three year-old male patient admitted to the hospital with chest pain. Non-ST myocardial infarction was diagnosed in the examinations. After coroner angiography, it was found coronary artery disease in addition between LAD proximal portion and main pulmonary artery fistula. Fistula repair and coronary bypass were performed successfully under cardiopulmonary bypass. Without hemodynamic problem in intensive care and service follow-up, the patient was discharged from the hospital in the seventh postoperative day. We think that surgical treatment of coronary fistulas in patients with coronary artery lesion is done at the earliest time would enable improvement in mortality and morbidity rates.

  1. Arterial hypertension and cancer. (United States)

    Milan, Alberto; Puglisi, Elisabetta; Ferrari, Laura; Bruno, Giulia; Losano, Isabel; Veglio, Franco


    Arterial hypertension and cancer are two of the most important causes of mortality in the world; correlations between these two clinical entities are complex and various. Cancer therapy using old (e.g., mitotic spindle poisons) as well as new (e.g., monoclonal antibody) drugs may cause arterial hypertension through different mechanisms; sometimes the increase of blood pressure levels may be responsible for chemotherapy withdrawal. Among newer cancer therapies, drugs interacting with the VEGF (vascular endothelial growth factors) pathways are the most frequently involved in hypertension development. However, many retrospective studies have suggested a relationship between antihypertensive treatment and risk of cancer, raising vast public concern. The purposes of this brief review have then been to analyse the role of chemotherapy in the pathogenesis of hypertension, to summarize the general rules of arterial hypertension management in this field and finally to evaluate the effects of antihypertensive therapy on cancer disease.

  2. Tone burst evoked otoacoustic emissions in neonates Emissões otoacústicas evocadas por estímulo "tone burst" em neonatos

    Directory of Open Access Journals (Sweden)

    Jordana Costa Soares


    Full Text Available A potential research project in otoacoustic emissions is the use tone bursts - frequency-specific stimulus. AIM:to study otoacoustic emission responses evoked by tone bursts in neonates with hearing loss risk factors. MATERIALS AND METHODS: 21 neonates with risk factors for hearing loss (study group and 30 neonates without these risk factors (control group were evaluated by otoacoustic emissions at the frequency range of 2,000 and 4,000 hertz. STUDY: Clinical and experimental. RESULTS: There was a right ear advantage in female individuals and in the control group, although without statistical significance. Mean "Response" values at 2,000 hertz were 17.73 dB in the control group and 16.55 dB in the study group for female subjects; and 16.63 dB in the control group and 16.12 dB in the study group for male subjects. At 4,000 hertz, the values were 14.63 dB in the control group and 15.09 dB in the study group for female subjects; and 18.57 dB in the control group and 15.06 dB in the study group for male subjects. CONCLUSION: Tone bursts may help evaluate cochlear function in neonates.Uma possibilidade de pesquisa em emissões otoacústicas é utilização do estímulo de frequência específica "tone burst". OBJETIVO: Verificar as respostas das emissões otoacústicas evocadas por estímulo "tone burst" em neonatos com indicadores de risco para perda auditiva. MATERIAL E MÉTODO: Foram avaliados 21 neonatos com indicadores de risco para perda auditiva (grupo estudo e 30 neonatos sem indicadores (grupo controle por meio das emissões otoacústicas nas frequências de 2000 e 4000 hertz. ESTUDO: Clínico e experimental. RESULTADOS: Houve vantagem da orelha direita, do gênero feminino e do grupo controle, embora sem significância estatística. Os valores médios de "Response" em 2000 hertz foram 17,73 dB no grupo controle e 16,55 dB no grupo estudo, para o gênero feminino e 16,63 dB no grupo controle e 16,12 dB no grupo estudo, para o g

  3. Idiopathic pulmonary artery aneurysm. (United States)

    Kotwica, Tomasz; Szumarska, Joanna; Staniszewska-Marszalek, Edyta; Mazurek, Walentyna; Kosmala, Wojciech


    Pulmonary artery aneurysm (PAA) is an uncommon lesion, which may be associated with different etiologies including congenital cardiovascular diseases, systemic vasculitis, connective tissue diseases, infections, and trauma. Idiopathic PAA is sporadically diagnosed by exclusion of concomitant major pathology. We report a case of a 56-year-old female with an idiopathic pulmonary artery dilatation identified fortuitously by echocardiography and confirmed by contrast-enhanced computed tomography. Neither significant pulmonary valve dysfunction nor pulmonary hypertension and other cardiac abnormalities which might contribute to the PAA development were found. Here, we describe echocardiographic and computed tomography findings and review the literature on PAA management.

  4. Left Anterior Descending Artery-Pulmonary Artery Fistula

    Directory of Open Access Journals (Sweden)

    Turan Ege


    Full Text Available Despite the fact that coronary arteriovenous fistulas constitute approximately half (48% of coronary artery anomalies, they are rarely seen anomalies. In this report,we aim to present a coronary arteriovenous fistula case detected during a coronary angiography between left anterior descending artery and pulmonary artery.

  5. Pulmonary arterial hypertension in children after neonatal arterial switch operation

    NARCIS (Netherlands)

    Zijlstra, Willemijn Mh; Elmasry, Ola; Pepplinkhuizen, Shari; Ivy, D Dunbar; Bonnet, Damien; Lévy, Marilyne; Gavilan, Jose Luis; Torrent-Vernetta, Alba; Mendoza, Alberto; Del Cerro, Maria Jesus; Moledina, Shahin; Berger, Rolf M. F.


    OBJECTIVES: Paediatric pulmonary arterial hypertension (PAH) after neonatal arterial switch operation (ASO) for transposition of the great arteries (TGA) is a clinically recognised entity with an estimated incidence of 0.6%-1.0%. Nevertheless, a clinical characterisation is lacking. We present an in

  6. Pharmacological modulation of arterial stiffness.

    LENUS (Irish Health Repository)

    Boutouyrie, Pierre


    Arterial stiffness has emerged as an important marker of cardiovascular risk in various populations and reflects the cumulative effect of cardiovascular risk factors on large arteries, which in turn is modulated by genetic background. Arterial stiffness is determined by the composition of the arterial wall and the arrangement of these components, and can be studied in humans non-invasively. Age and distending pressure are two major factors influencing large artery stiffness. Change in arterial stiffness with drugs is an important endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Drugs that independently affect arterial stiffness include antihypertensive drugs, mostly blockers of the renin-angiotensin-aldosterone system, hormone replacement therapy and some antidiabetic drugs such as glitazones. While the quest continues for \\'de-stiffening drugs\\

  7. Effet-dose de l’acide oléique alimentaire. Cet acide est-il conditionnellement essentiel ?


    Bourre Jean-Marie; Dumont Odile; Durand Georges


    Dans un travail précédent [1] nous avons montré que, globalement, au terme de la période de gestation-lactation chez des rats de 21 jours, la carence alimentaire en acide oléique entraîne une diminution de la concentration en 18:1(n-9); la synthèse endogène ne compense donc pas l’absence d’acide oléique dans les aliments. Afin de déterminer exactement l’effet de la présence et de la concentration de l’acide oléique dans l’alimentation sur la composition en acides gras de divers organes, les h...

  8. Effets du titane et du niobium sur l'oxydation à 950circC d'aciers ferritiques (United States)

    Issartel, C.; Buscail, H.; Caudron, E.; Cueff, R.; Riffard, F.; El Messki, S.; Karimi, N.; Antoni, L.


    Nous avons étudié l'effet du titane et du niobium sur l'oxydation à 950circC d'un acier Fe-Cr chrominoformeur. La DRX in situ montre que le titane semble s'oxyder en formant Cr{2}TiO{5} et TiO{2} qui contribuent à une augmentation de la prise de masse des échantillons. Une partie du titane issu de ces oxydes semble doper la couche de chromine. Sa présence augmente la concentration en lacunes cationiques dans la chromine et augmente donc la diffusion du chrome dans la couche. Nous avons aussi montré que le niobium n'a pas d'influence sur l'oxydation de ce type d'acier à 950circC.

  9. Mechanisms of endothelial dysfunction in resistance arteries from patients with end-stage renal disease.

    Directory of Open Access Journals (Sweden)

    Leanid Luksha

    Full Text Available The study focuses on the mechanisms of endothelial dysfunction in the uremic milieu. Subcutaneous resistance arteries from 35 end-stage renal disease (ESRD patients and 28 matched controls were studied ex-vivo. Basal and receptor-dependent effects of endothelium-derived factors, expression of endothelial NO synthase (eNOS, prerequisites for myoendothelial gap junctions (MEGJ, and associations between endothelium-dependent responses and plasma levels of endothelial dysfunction markers were assessed. The contribution of endothelium-derived hyperpolarizing factor (EDHF to endothelium-dependent relaxation was impaired in uremic arteries after stimulation with bradykinin, but not acetylcholine, reflecting the agonist-specific differences. Diminished vasodilator influences of the endothelium on basal tone and enhanced plasma levels of asymmetrical dimethyl L-arginine (ADMA suggest impairment in NO-mediated regulation of uremic arteries. eNOS expression and contribution of MEGJs to EDHF type responses were unaltered. Plasma levels of ADMA were negatively associated with endothelium-dependent responses in uremic arteries. Preserved responses of smooth muscle to pinacidil and NO-donor indicate alterations within the endothelium and tolerance of vasodilator mechanisms to the uremic retention products at the level of smooth muscle. We conclude that both EDHF and NO pathways that control resistance artery tone are impaired in the uremic milieu. For the first time, we validate the alterations in EDHF type responses linked to kinin receptors in ESRD patients. The association between plasma ADMA concentrations and endothelial function in uremic resistance vasculature may have diagnostic and future therapeutic implications.

  10. Ischemia as a potential etiologic factor in idiopathic unilateral sudden sensorineural hearing loss: Analysis of posterior circulation arteries. (United States)

    Kim, Chulho; Sohn, Jong-Hee; Jang, Min Uk; Hong, Sung-Kwang; Lee, Joong-Seob; Kim, Hyung-Jong; Choi, Hui-Chul; Lee, Jun Ho


    The association between idiopathic sudden sensorineural hearing loss (ISSNHL) and the radiologic characteristics of the vertebrobasilar artery is unclear. We hypothesized that the degree and direction of vertebrobasilar artery curvature in the posterior circulation contribute to the occurrence of ISSNHL. We consecutively enrolled patients diagnosed with unilateral ISSNHL in two tertiary hospitals. Magnetic resonance images were performed in all patients to exclude specific causes of ISSNHL, such as vestibular schwannoma, chronic mastoiditis, and anterior inferior cerebellar artery infarct. We measured the following parameters of posterior circulation: vertebral and basilar artery diameter, the degree of basilar artery curvature (modified smoker criteria), and vertebral artery dominance. Pure tone audiometries were performed at admission and again 1 week and 3 months later. A total of 121 ISSNHL patients (mean age, 46.0 ± 17.3 years; 48.8% male) were included in these analyses. The proportion of patients with the left side hearing loss was larger than the proportion with the right side hearing loss (left, 57.9%; right, 42.1%). The majority of patients were characterized by a left dominant vertebral artery and right-sided basilar artery curvature. The direction of the basilar artery curvature was significantly associated with hearing loss lateralization (p = 0.036). Age and sex matched multivariable analyses revealed the absence of diabetes and right-sided basilar artery curvature as significant predictors for left sided hearing loss. There was no statistical difference between atherosclerotic cardiovascular risk score (high versus low) and hearing outcomes at 3 months. In ISSNHL, the laterality of hearing loss was inversely associated with the direction of basilar artery curvature. Our results, therefore, indicate the importance of vascular assessment when evaluating ISSNHL.

  11. Pulmonary artery sling: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Gil Hyun; Lee, Sun Wha; Cha, Sung Ho [Kyunghee University College of Medicine, Seoul (Korea, Republic of)


    Aberrant left-sided pulmonary artery(pulmonary artery sling) is an uncommon anomaly,which may cause significant respiratory abnormality. We report a case of pulmonary artery sling which is combined with persistent left superior vena cava and dextrocardia. This case were identified by esophagogram and CT and confirmed by MRI and angiography. We consider that MRI is a valuable new method for the diagnosis of aberrant left-sided pulmonary artery.

  12. Intracranial artery dissection

    NARCIS (Netherlands)

    Sikkema, T.; Uyttenboogaart, Maarten; Eshghi, O.; De Keyser, J.; Brouns, R.; van Dijk, J.M.C.; Luijckx, G. J.


    The aim of this narrative review is to evaluate the pathogenesis, clinical features, diagnosis, treatment and prognosis of intracranial artery dissection (IAD). IAD is a rare and often unrecognized cause of stroke or subarachnoid haemorrhage (SAH), especially in young adults. Two types of IAD can be

  13. Popliteal artery entrapment syndrome

    DEFF Research Database (Denmark)

    Altintas, Ümit; Helgstrand, Ulf Johan Vilhelm; Hansen, Marc A;


    The purpose of this study was to report our experience with popliteal artery entrapment syndrome (PAES) with special emphasis on the applicability of duplex ultrasound scanning (DUS) when diagnosing PAES. In addition to examining the correlation between DUS and intraoperative findings...

  14. Arterial Emboli Complicating Cisplatin Therapy


    Tait, Campbell D.; Rankin, Elaine M


    We report three cases of arterial emboli in patients with lung cancer treated with cisplatin chemotherapy. All three patients were managed without surgical intervention but subsequent oncological treatment was complicated by the sequelae of arterial emboli. We discuss the issues surrounding these patients and the importance of identifying patients at risk of arterial embolic phenomena with cisplatin treatment.

  15. Tone matters for Cantonese-English bilingual children's English word reading development: A unified model of phonological transfer. (United States)

    Tong, Xiuli; He, Xinjie; Deacon, S Hélène


    Languages differ considerably in how they use prosodic features, or variations in pitch, duration, and intensity, to distinguish one word from another. Prosodic features include lexical tone in Chinese and lexical stress in English. Recent cross-sectional studies show a surprising result that Mandarin Chinese tone sensitivity is related to Mandarin-English bilingual children's English word reading. This study explores the mechanism underlying this relation by testing two explanations of these effects: the prosodic hypothesis and segmental phonological awareness transfer. We administered multiple measures of Cantonese tone sensitivity, English stress sensitivity, segmental phonological awareness in Cantonese and English, nonverbal ability, and English word reading to 123 Cantonese-English bilingual children ages 7 and 8 years. Structural equation modeling revealed a longitudinal prediction of Cantonese tone sensitivity to English word reading between 8 and 9 years of age. This relation was realized through two parallel routes. In one, Cantonese tone sensitivity predicted English stress sensitivity, and English stress sensitivity, in turn, significantly predicted English word reading, as postulated by the prosodic hypothesis. In the second, Cantonese tone sensitivity predicted English word reading through the transfer of segmental phonological awareness between Cantonese and English, as predicted by segmental phonological transfer. These results support a unified model of phonological transfer, emphasizing the role of tone in English word reading for Cantonese-English bilingual children.

  16. Cerebral Arterial Fenestrations (United States)

    Cooke, Daniel L; Stout, Charles E; Kim, Warren T; Kansagra, Akash P; Yu, John Paul; Gu, Amy; Jewell, Nicholas P; Hetts, Steven W; Higashida, Randall T; Dowd, Christopher F; Halbach, Van V


    Summary Arterial fenestrations are an anatomic variant with indeterminate significance. Given the controversy surrounding fenestrations we sought their prevalence within our practice along with their association with other cerebrovascular anomalies. We retrospectively reviewed 10,927 patients undergoing digital subtraction angiography between 1992 and 2011. Dictated reports were searched for the terms “fenestration” or “fenestrated” with images reviewed for relevance, yielding 228 unique cases. A Medline database search from February 1964 to January 2013 generated 304 citations, 127 cases of which were selected for analysis. Cerebral arterial fenestrations were identified in 228 patients (2.1%). At least one aneurysm was noted in 60.5% of patients, with an aneurysm arising from the fenestration in 19.6% of patients. Aneurysmal subarachnoid hemorrhage or non-aneurysmal subarachnoid hemorrhage were present in 60.1% and 15.8%, respectively. For the subset of patients with an aneurysm arising directly from a fenestration relative to those patients with an aneurysm not immediately associated with a fenestration, the prevalence of aneurysmal subarachnoid hemorrhage was 66.7% vs. 58.6% (p = 0.58). Fenestrations were more often within the posterior circulation (73.2%) than the anterior circulation (24.6%), though there was no difference in the prevalence of aneurysms within these groups (61.1% vs. 60.7%, p = 1.0). Cerebral arterial fenestrations are an anatomic variant more often manifesting at the anterior communicating arterial complex and basilar artery and with no definite pathological relationship with aneurysms. PMID:24976087

  17. Two-tone intensity-modulated optical stimulus for self-referencing microwave characterization of high-speed photodetectors (United States)

    Wang, Heng; Zhang, Shangjian; Zou, Xinhai; Zhang, Yali; Lu, Rongguo; Zhang, Zhiyao; Zhang, Xiaoxia; Liu, Yong


    The two-tone intensity modulated optical stimulus is proposed and demonstrated for measuring the high-frequency response of photodetectors. The method provides a narrow linewidth and wide bandwidth optical stimulus based on the two-tone modulation of a Mach-Zehnder electro-optical intensity modulator, and achieves the self-referenced measurement of photodetectors without the need for correcting the power variation of optical stimulus. Moreover, the two-tone intensity modulation method allows bias-independent measurement with doubled measuring frequency range. In the experiment, the consistency between our method and the conventional methods verifies the simple but accurate measurement.

  18. The Dissociation between Polarity, Semantic Orientation, and Emotional Tone as an Early Indicator of Cognitive Impairment (United States)

    Arias Tapia, Susana A.; Martínez-Tomás, Rafael; Gómez, Héctor F.; Hernández del Salto, Víctor; Sánchez Guerrero, Javier; Mocha-Bonilla, J. A.; Barbosa Corbacho, José; Khan, Azizudin; Chicaiza Redin, Veronica


    The present study aims to identify early cognitive impairment through the efficient use of therapies that can improve the quality of daily life and prevent disease progress. We propose a methodology based on the hypothesis that the dissociation between oral semantic expression and the physical expressions, facial gestures, or emotions transmitted in a person's tone of voice is a possible indicator of cognitive impairment. Experiments were carried out with phrases, analyzing the semantics of the message, and the tone of the voice of patients through unstructured interviews in healthy people and patients at an early Alzheimer's stage. The results show that the dissociation in cognitive impairment was an effective indicator, arising from patterns of inconsistency between the analyzed elements. Although the results of our study are encouraging, we believe that further studies are necessary to confirm that this dissociation is a probable indicator of cognitive impairment. PMID:27683555

  19. Multi-Band Multi-Tone Tunable Millimeter-Wave Frequency Synthesizer For Satellite Beacon Transmitter (United States)

    Simons, Rainee N.; Wintucky, Edwin G.


    This paper presents the design and test results of a multi-band multi-tone tunable millimeter-wave frequency synthesizer, based on a solid-state frequency comb generator. The intended application of the synthesizer is in a satellite beacon transmitter for radio wave propagation studies at K-band (18 to 26.5 GHz), Q-band (37 to 42 GHz), and E-band (71 to 76 GHz). In addition, the architecture for a compact beacon transmitter, which includes the multi-tone synthesizer, polarizer, horn antenna, and power/control electronics, has been investigated for a notional space-to-ground radio wave propagation experiment payload on a small satellite. The above studies would enable the design of robust high throughput multi-Gbps data rate future space-to-ground satellite communication links.


    Institute of Scientific and Technical Information of China (English)



    The word control key is one of the applications of talker recognition. Chinese differs from English or Japanese, and the four Chinese tones are important characteristics,In this paper, the four Chinese tones are analysed and nine parameters are introduced. They are (1) the pitch period (2) the two parameters of the time length of talker pronounciation, (3) the pitch pattern gradinet (in 5 sections) and (4) the sum of spectral distances. Many Chinese words consist of one syllable, lt's combinationrules consist of single vowels, diphthongs or trinphtiogs.The spectrum of the vowel uses FFT in the medium frame.This method uses a group of input signals that consists of three input signal, and decides the logic “pass” or “out” .The experimental recognition ratio is over 90% for the reference talker, 7.2% for the other talker with the reference input word,and 0% for the other talker with random input words.

  1. Modulation of vagal tone enhances gastroduodenal motility and reduces somatic pain sensitivity

    DEFF Research Database (Denmark)

    Frøkjaer, J B; Bergmann, Sigrid; Brock, C


    BACKGROUND: The parasympathetic nervous system, whose main neural substrate is the vagus nerve, exerts a fundamental antinociceptive role and influences gastrointestinal sensori-motor function. Our research question was to whether combined electrical and physiological modulation of vagal tone......-controlled, cross-over study with an active protocol including stimulation of auricular branch of the vagus nerve, and breathing at full inspiratory capacity and forced full expiration. Recording of cardiac derived parameters including cardiac vagal tone, moderate pain thresholds to muscle, and bone pressure......, using transcutaneous electrical vagal nerve stimulation (t-VNS) and deep slow breathing (DSB) respectively, could increase musculoskeletal pain thresholds and enhance gastroduodenal motility in healthy subjects. METHODS: Eighteen healthy subjects were randomized to a subject-blinded, sham...

  2. Alterations in tone of voice in patients with restrictive anorexia nervosa: A pilot study

    Directory of Open Access Journals (Sweden)

    Concepción García-Santana


    Full Text Available This article is about the tone of voice (acoustic perception in patients with restrictive anorexia nervosa (AN-R. Our goal was to study whether or not there is an alteration of the tone in restrictive anorexia nervosa when the disease has started in the puberty. The total sample consisted of 148 subjects divided in two groups: control (n=102 and AN-R (n=46. The voice´s fundamental frequencies (F0 were determined based on the repetition of two phonemes ("a" and "i" and measured by a microphone Plantonic 300 and a digital recorder. We analyzed the voice´s F0 using Praat software. We present the first data for the normal range of the F0 in Spanish healthy women from 9 to 17 years old who were Spanish native speakers. Finally, we show a comparison of data between AN-R patients and control group.

  3. Frequency-Zooming ARMA Modeling for Analysis of Noisy String Instrument Tones

    Directory of Open Access Journals (Sweden)

    Paulo A. A. Esquef


    Full Text Available This paper addresses model-based analysis of string instrument sounds. In particular, it reviews the application of autoregressive (AR modeling to sound analysis/synthesis purposes. Moreover, a frequency-zooming autoregressive moving average (FZ-ARMA modeling scheme is described. The performance of the FZ-ARMA method on modeling the modal behavior of isolated groups of resonance frequencies is evaluated for both synthetic and real string instrument tones immersed in background noise. We demonstrate that the FZ-ARMA modeling is a robust tool to estimate the decay time and frequency of partials of noisy tones. Finally, we discuss the use of the method in synthesis of string instrument sounds.

  4. Complex-Tone Pitch Discrimination in Listeners With Sensorineural Hearing Loss

    DEFF Research Database (Denmark)

    Bianchi, Federica; Fereczkowski, Michal; Zaar, Johannes


    Physiological studies have shown that noise-induced sensorineural hearing loss (SNHL) enhances the amplitude of envelope coding in auditory-nerve fibers. As pitch coding of unresolved complex tones is assumed to rely on temporal envelope coding mechanisms, this study investigated pitch-discrimination...... performance in listeners with SNHL. Pitch-discrimination thresholds were obtained for 14 normal-hearing (NH) and 10 hearing-impaired (HI) listeners for sine-phase (SP) and random-phase (RP) complex tones. When all harmonics were unresolved, the HI listeners performed, on average, worse than NH listeners...... in the RP condition but similarly to NH listeners in the SP condition. The increase in pitch-discrimination performance for the SP relative to the RP condition (F0DL ratio) was significantly larger in the HI as compared with the NH listeners. Cochlear compression and auditory-filter bandwidths were...

  5. Auditory habituation to simple tones: reduced evidence for habituation in children compared to adults

    Directory of Open Access Journals (Sweden)

    Jana eMuenssinger


    Full Text Available Habituation – the response decrement to repetitively presented stimulation - is a basic cognitive capability and suited to investigate development and integrity of the human brain. To evaluate the developmental process of auditory habituation, the current study used magnetoencephalography to investigate auditory habituation, dishabituation and stimulus specificity in children and adults and compared the results between age groups. Twenty-nine children (Mage = 9.69 years, SD ± 0.47 and 14 adults (Mage = 29.29 years, SD ± 3.47 participated in the study and passively listened to a habituation paradigm consisting of 100 trains of tones which were composed of five 500Hz tones, one 750Hz tone (dishabituator and another two 500Hz tones, respectively while focusing their attention on a silent movie. Adults showed the expected habituation and stimulus specificity within-trains while no response decrement was found between trains. Sensory adaptation or fatigue as a source for response decrement in adults is unlikely due to the strong reaction to the dishabituator (stimulus specificity and strong mismatch negativity responses. However, in children neither habituation nor dishabituation or stimulus specificity could be found within-trains, response decrement was found across trains. It can be speculated that the differences between children and adults are linked to differences in stimulus processing due to attentional processes. This study shows developmental differences in task-related brain activation and discusses the possible influence of broader concepts such as attention, which should be taken into account when comparing performance in an identical task between age groups.

  6. p66shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone


    Kleman, Amy M.; Brown, Jacquelynn E.; Zeiger, Stephanie L.H.; Hettinger, Jane C.; Brooks, Joshua D.; Holt, Benjamin; Morrow, Jason D.; Musiek, Erik S.; Milne, Ginger L.; McLaughlin, BethAnn


    Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling ...

  7. Oxide nanoparticle EUV resists: toward understanding the mechanism of positive and negative tone patterning

    KAUST Repository

    Chakrabarty, Souvik


    DUV, EUV and e-beam patterning of hybrid nanoparticle photoresists have been reported previously by Ober and coworkers. The present work explores the underlying mechanism that is responsible for the dual tone patterning capability of these photoresist materials. Spectroscopic results correlated with mass loss and dissolution studies suggest a ligand exchange mechanism responsible for altering the solubility between the exposed and unexposed regions. © 2013 SPIE.

  8. Effects of superoxide generating systems on muscle tone, cholinergic and NANC responses in cat airway. (United States)

    Bauer, V; Nakajima, T; Pucovsky, V; Onoue, H; Ito, Y


    To study the possible role of reactive oxygen species in airway hyperreactivity, we examined the effects of the superoxide anion radical (O(2)(-)) generating systems, pyrogallol and xanthine with xanthine oxidase, on muscle tone, excitatory and inhibitory neurotransmission in the cat airway. Smooth muscle contraction or non-adrenergic non-cholinergic (NANC) relaxation evoked by electrical field stimulation (EFS) were measured before or after O(2)(-) generating systems with or without diethydithiocarbamic acid (DEDTCA), an inhibitor of endogenous superoxide dismutase (SOD). Resting membrane potential or excitatory junction potential (EJP) were also measured in vitro. Both pyrogallol and xanthine/xanthine oxidase produced biphasic changes in basal and elevated (by 5-HT) muscle tone. After SOD pretreatment, both systems consistently produced a prolonged contraction, thereby indicating that O(2)(-) was converted to H(2)O(2) by the action of SOD and as a result the actions of O(2)(-) were lost but those of H(2)O(2) introduced. The O(2)(-) showed no significant effect on smooth muscle contraction or EJP evoked by EFS, however after DEDTCA pretreatment, it evoked initial enhancement followed by suppression of the contraction and EJP. DEDTCA pretreatment ameliorated the inhibitory action of pyrogallol and xanthine/xanthine oxidase on the NANC relaxation, probably because O(2)(-) could combine with endogenous NO to form peroxynitrite. These results indicate that the O(2)(-) generating systems have multiple actions, presumably due to the presence and simultaneous action of at least two different reactive oxygen species (O(2)(-) and H(2)O(2)). While H(2)O(2) seems to be responsible for elevation of muscle tone and augmentation of smooth muscle contraction by EFS, O(2)(-) inhibits muscle tone, cholinergic and NANC neurotransmission.

  9. Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone


    Hughes, Sam; Hickey, Louise; Donaldson, Lucy F.; Lumb, Bridget M; Pickering, Anthony E.


    The descending noradrenergic (NAergic) projection to the spinal cord forms part of an endogenous analgesic system. After nerve injury, a localised failure in this compensatory system has been implicated as a permissive factor in the development of neuropathic sensitisation. We investigated whether restoring descending NAergic tone with intrathecal reboxetine can oppose the development of the neuropathic pain phenotype after tibial nerve transection (TNT). Rats had a lumbar intrathecal cathete...

  10. Cortical activity associated with the detection of temporal gaps in tones: A magnetoencephalography study

    Directory of Open Access Journals (Sweden)

    Takako eMitsudo


    Full Text Available We used magnetoencephalography (MEG in two experiments to investigate spatio-temporal profiles of brain responses to gaps in tones. Stimuli consisted of leading and trailing markers with gaps between the two markers of 0, 30, or 80 ms. Leading and trailing markers were 300 ms pure tones at 800 Hz or 3200 Hz. Two conditions were examined: the within-frequency (WF condition in which the leading and trailing markers had identical frequencies, and the between-frequency (BF condition in which they had different frequencies. Using minimum-norm estimates (MNE, we localized the source activations at the time of the peak response to the trailing markers. Results showed that MEG signals in response to 800 Hz and 3200 Hz tones were localized in different regions within the auditory cortex, indicating that the frequency pathways activated by the two markers were spatially represented. The time course of regional activity (RA was extracted from each localized region for each condition. In Experiment 1, which used a continuous tone for the WF 0-ms stimulus, the N1m amplitude for the trailing marker in the WF condition differed depending on gap duration but not tonal frequency. In contrast, N1m amplitude in BF conditions differed depending on the frequency of the trailing marker. In Experiment 2, in which the 0-ms gap stimulus in the WF condition was made from two markers and included an amplitude reduction in the middle, the amplitude in WF and BF conditions changed depending on frequency, but not gap duration. The difference in temporal characteristics between WF and BF conditions could be observed in the regional activity.

  11. Cyclostationary Model Based Multiple-Tone Interference Rejection in DSSS Communication Systems

    Institute of Scientific and Technical Information of China (English)


    Multiple-tone interference is a kind of narrow band interference appears in Direct Sequence (DS) Spread Spectrum (SS) communication system frequently that degrades the system performance. Most open literature studies on narrowband interference rejection assumed stationary SS signal and interference. SS signal and interference are modeled as cyclostationary and based on cyclostationary model, an interference rejection algorithm is proposed. Through computer simulation, it is shown that the performance of the SS system can be improved considerably after adopting this algorithm.

  12. Laser toning for melasma: A single-centre experience with 38 970 cases. (United States)

    Tian, Brian


    Melasma is a common pigmentation in Asian women. Lasers have been used to lighten melasma, although with variable outcomes and complications. In Asia, laser toning is a common technique used to safely lighten melasma. However, no large studies have been performed to validate efficacy. In our study, we demonstrate that in 38 970 Asian women, at least 35 890 patients (92.1%) had noticeable to excellent improvement in their melasma.

  13. Phase Noise Influence in Optical OFDM Systems employing RF Pilot Tone for Phase Noise Cancellation


    Jacobsen, Gunnar; Kazovsky, Leonid G.; Xu, TianHua; Popov, Sergei; Li, Jie; Zhang, Yimo; Friberg, Ari T.


    For coherent and direct-detection Orthogonal Frequency Division Multiplexed (OFDM) systems employing radio frequency (RF) pilot tone phase noise cancellation the influence of laser phase noise is evaluated. Novel analytical results for the common phase error and for the (modulation dependent) inter carrier interference are evaluated based upon Gaussian statistics for the laser phase noise. In the evaluation it is accounted for that the laser phase noise is filtered in the correlation signal d...

  14. SmarTone-Vodafone 手机版YouTube大玩现金回馈

    Institute of Scientific and Technical Information of China (English)


    一向鬼点子众多的SmarTone-Vodafone最近又有新招,他们专门为青少年设置了Wap网站“Teen地带”内容包括MV、铃声、full track、游戏、浏览、优惠券等,而且还有“随身IM”(类似MSN)。

  15. White Matter Changes Associated with Resting Sympathetic Tone in Frontotemporal Dementia vs. Alzheimer's Disease.

    Directory of Open Access Journals (Sweden)

    Mario F Mendez

    Full Text Available Resting sympathetic tone, a measure of physiological arousal, is decreased in patients with apathy and inertia, such as those with behavioral variant frontotemporal dementia (bvFTD and other frontally-predominant disorders.To identify the neuroanatomical correlates of skin conductance levels (SCLs, an index of resting sympathetic tone and apathy, among patients with bvFTD, where SCLs is decreased, compared to those with Alzheimer's disease (AD, where it is not.This study analyzed bvFTD (n = 14 patients and a comparison group with early-onset AD (n = 19. We compared their resting SCLs with gray matter and white matter regions of interest and white matter measures of fiber integrity on magnetic resonance imaging and diffusion tensor imaging.As expected, bvFTD patients, compared to AD patients, had lower SCLs, which correlated with an apathy measure, and more gray matter loss and abnormalities of fiber integrity (fractional anisotropy and mean diffusivity in frontal-anterior temporal regions. After controlling for group membership, the SCLs were significantly correlated with white matter volumes in the cingulum and inferior parietal region in the right hemisphere.Among dementia patients, SCLs, and resting sympathetic tone, may correlate with quantity of white matter, rather than with gray matter or with white matter fiber integrity. Loss of white matter volumes, especially involving a right frontoparietal network, may reflect chronic loss of cortical axons that mediate frontal control of resting sympathetic tone, changes that could contribute to the apathy and inertia of bvFTD and related disorders.

  16. Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries

    DEFF Research Database (Denmark)

    Sheykhzade, Majid; Simonsen, Anja Hviid; Boonen, Harrie C.M.


    The influence of ageing on the passive and active tension and pharmacodynamic characteristics of intramural coronary arteries from 3-month-old and 2-year-old male Wistar rats was investigated using an isometric myograph. The passive vessel wall tension measured in Ca2+-free physiological salt...... solution at L0 was significantly greater in arteries from old rats (1.46 ± 0.10 Nm–1, n = 7) than in young rats (1.13 ± 0.13 Nm–1, n = 6). However, the maximal active tension at L0 was similar. The spontaneous myogenic tone was increased by age and the vasorelaxation induced by extracellular K......+ was significantly higher in coronary arteries of old rats. The sensitivity (pD2) to 5-HT was significantly higher in arteries from old (6.43 ± 0.11, n = 22) than from young rats (6.16 ± 0.08, n = 29). Ketanserin induced a concentration-dependent rightward shift of the 5-HT concentration-response curve in arteries...

  17. Effect of Electroacupuncture Combined with Tuina on Lumbar Muscle Tone in Patients with Acute Lumbar Sprain

    Institute of Scientific and Technical Information of China (English)

    Fan Yuan-zhi; Wu Yao-chi


    Objective: To observe the clinical effect of electroacupuncture (EA) combined with tuina on acute lumbar sprain and lumbar muscle tone before and after treatment. Methods: A total of 130 acute lumbar sprain cases were randomly allocated into an observation group and a control group, 65 in each group. Cases in the observation group were treated with EA combined with tuina, whereas cases in the control group were treated with Diclofenac Sodium Dual Release Enteric-coated capsules. The muscle tones in two groups were tested before and after treatment. Results: The recovery rate and overall response rate in the observation group were 66.2% and 93.8% respectively, versus 56.9% and 87.7% in the control group, showing no between-group statistical significances (P>0.05). After treatment, the force-displacement area under curve (AUC) in both groups showed a significance difference (P Conclusion: Both EA combined with tuina and aforementioned oral medication have remarkable effects for acute lumbar sprain, and the former can better improve the lumbar muscle tone in patients with acute lumbar sprain.

  18. Developmental changes in mismatch responses to mandarin consonants and lexical tones from early to middle childhood.

    Directory of Open Access Journals (Sweden)

    Huei-Mei Liu

    Full Text Available The purpose of this study was to use mismatch responses (MMRs to explore the dynamic changes of Mandarin speech perception abilities from early to middle childhood. Twenty preschoolers, 18 school-aged children, and 26 adults participated in this study. Two sets of synthesized speech stimuli varying in Mandarin consonant (alveolo-palatal affricate vs. fricative and lexical tone features (rising vs. contour tone were used to examine the developmental course of speech perception abilities. The results indicated that only the adult group demonstrated typical early mismatch negativity (MMN responses, suggesting that the ability to discriminate specific speech cues in Mandarin consonant and lexical tone is a continuing process in preschool- and school-aged children. Additionally, distinct MMR patterns provided evidence indicating diverse developmental courses to different speech characteristics. By incorporating data from the two speech conditions, we propose using MMR profiles consisting of mismatch negativity (MMN, positive mismatch response (p-MMR, and late discriminative negativity (LDN as possible brain indices to investigate speech perception development.


    Institute of Scientific and Technical Information of China (English)

    张晓君; 赵毅; 高玉红; 耿稚萍; 余华峰


    Objective. To explore the changes of three-tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty-four patients of aging dementia underwent traditional P300 (2t-P300) and three-tone paradigm auditory P300 (3t-P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52. 9% ) by 2t-P300, and in 26 of 30 pa-tients who finished the 3t-P300 tests (86. 7% ). In 2t-P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t-P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t-P300 was found in 13 of 16 cases which showed normal 2t-P300. Besides prolonged and bad-shaped P300, no certain response of P300 to rare non-target stimulus (r-nT) was found in 10 mild cases by 3t-P300. Conclusion. Three-tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r-nT in 3t-P300 is an important index in early diagnosis of mild dementia.

  20. Rapid extraction of lexical tone phonology in Chinese characters: a visual mismatch negativity study.

    Directory of Open Access Journals (Sweden)

    Xiao-Dong Wang

    Full Text Available BACKGROUND: In alphabetic languages, emerging evidence from behavioral and neuroimaging studies shows the rapid and automatic activation of phonological information in visual word recognition. In the mapping from orthography to phonology, unlike most alphabetic languages in which there is a natural correspondence between the visual and phonological forms, in logographic Chinese, the mapping between visual and phonological forms is rather arbitrary and depends on learning and experience. The issue of whether the phonological information is rapidly and automatically extracted in Chinese characters by the brain has not yet been thoroughly addressed. METHODOLOGY/PRINCIPAL FINDINGS: We continuously presented Chinese characters differing in orthography and meaning to adult native Mandarin Chinese speakers to construct a constant varying visual stream. In the stream, most stimuli were homophones of Chinese characters: The phonological features embedded in these visual characters were the same, including consonants, vowels and the lexical tone. Occasionally, the rule of phonology was randomly violated by characters whose phonological features differed in the lexical tone. CONCLUSIONS/SIGNIFICANCE: We showed that the violation of the lexical tone phonology evoked an early, robust visual response, as revealed by whole-head electrical recordings of the visual mismatch negativity (vMMN, indicating the rapid extraction of phonological information embedded in Chinese characters. Source analysis revealed that the vMMN was involved in neural activations of the visual cortex, suggesting that the visual sensory memory is sensitive to phonological information embedded in visual words at an early processing stage.

  1. The effect of mastication muscular tone on facial size in patients with Down syndrome

    Directory of Open Access Journals (Sweden)

    Margaretha Suharsini


    Full Text Available Muscular hypotonia is one of the clinical signs in patients with Down syndrome. As a characteristic of patients with Down syndrome, hypotonia is clearly evident in face expression and oral dysfunction. Dentocraniofacial growth abnormalities in patients with Down syndrome may be influenced by genetic and environmental factors. Stomatognathic system musculature as an environmental factor (factor outside the bone can affect dentocraniofacial growth by orofacial muscles activities when chewing, swallowing, breathing, and speaking. Oral dysfunctions commonly seen in patients with Down syndrome are open mouth, protruding tongue posture, difficulties when chewing, swallowing, and speaking, drooling, and mouth breathing. The purpose of this study was to observe how the mastication muscular tone affecting the facial size of Down syndrome patient. Twenty five of 14–18 years old children with Down syndrome were diagnosed by clinical characteristic and cytogenetic examination. Mastication muscular tone was described by masseter and temporalis muscle synergy and oral function, whereas the facial size consisted of facial size of lateral, anteroposterior and vertical growth. The result of regression test revealed that the degree of mastication muscular tone has a significant effect on facial size of the anteroposterior growth and facial size of vertical growth, but did not significantly influence the facial size of lateral growth.

  2. PCDD/Fs and dioxin-like PCBs in the Tone River, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Eiki; Heesoo, Eun; Koji, Baba; Tomohito, Arao; Shozo, Endo [National Institute for Agro-Environmental Sciences, Tsukuba (Japan); Tadashi, Sekino [Environmental Research Center, Tsukuba (Japan)


    Environmental pollution by PCDD/Fs has arisen exclusively from human activities, and for example, they are inadvertently produced from various combustion sources and manufacturing processes, such as municipal solid waste incineration steel production processes and chemical production processes. In Japan, it is well known that the environmental pollution has close relation to agricultural operation, that is, some PCDD/Fs are contained as impurities in a kind of pesticide. The Tone River is the largest basin area (about 16,900 km{sup 2}) in Japan, and after the Shinano River, is the second longest river (about 322 km). The river has many tributaries (about 800 rivers), and the rivers taking the Kokai River, the Kinu River, the Edo River, and the Watarase River as objects of the present study are also representative tributaries. Since the Tone River basin corresponding to about 4.5% of the total area of Japan leads about twelve million population corresponding to about 10% of the gross population in Japan, it plays an important part in a supply of water for human activities. Not only some residential zones near Tokyo and industrial zones but also representative agricultural zones in Japan expand in the basin expands, and especially the lower basin leads a leading granary. The objective of our effort is to investigate the levels of PCDD/Fs and PCBs in surface sediment and water samples from the Tone River and some related tributaries, and to assess their distribution and origin using congener-specific characterization approach.


    Directory of Open Access Journals (Sweden)

    Liliane Klaus


    Full Text Available This essay aims to discuss how tone at the top works in the traditional military contexts found in Latin America, and how the right tone could be adopted in corrupt military institutions to move towards an ethical role-modelling environment. For this endeavour, several strategies that can help military generals to fight military unethical culture in contaminated hierarchical organisations will be proposed, while a number of hypotheses on the institution’s functioning will be provided. Differently from private companies’ theoretical bias, the main suggested approach implies the initial establishment of a strong, transactional-based tone at the top as the main tool to fight military corruption. As a further step, after the corrupt culture has been neutralised, transactional leadership based on ethics could be slowly transformed into gentler versions of transformational style, but never letting the main fear of the harshest punishment evanesce. In summary, by showing that unethical leadership will necessarily pave the way for misconduct in traditional military organisations, we propose a cannonball strategy, based on a punishment and reward system, to reinforce integrity instead of gentler or charismatic leadership styles.

  4. The role of phonological alternation in speech production: evidence from Mandarin tone sandhi. (United States)

    Politzer-Ahles, Stephen; Zhang, Jie


    We investigate the role of phonological alternation during speech production in Mandarin using implicit priming, a paradigm in which participants respond faster to words in sets that are phonologically homogeneous than in sets that are phonologically heterogeneous. We test whether priming is obtained when words in a set share the same tones at the underlying level but have different tones at the surface level-i.e., when the set includes a word that undergoes a phonological alternation which changes the tone. Sets that are heterogeneous at the surface level (in which the heterogeneity is due to a phonological operation) failed to elicit priming, as did sets that are heterogeneous at the underlying and surface levels (in which the heterogeneity is due to the lexical representations). This finding suggests that the phonological alternation was computed before the initiation of articulation, offering evidence that the progression from underlying phonological representations to articulatory execution may be mediated online by phonological input-to-output mapping. Furthermore, sets of words that are heterogeneous only at the surface level showed a different trend than sets of words that are heterogeneous at both levels, suggesting that both the surface and underlying levels of representation play a role during speech production.

  5. Relating Pitch Awareness to Phonemic Awareness in Children: Implications for Tone-Deafness and Dyslexia

    Directory of Open Access Journals (Sweden)

    Psyche eLoui


    Full Text Available Language and music are complex cognitive and neural functions that rely on awareness of one’s own sound productions. Information on the awareness of vocal pitch, and its relation to phonemic awareness which is crucial for learning to read, will be important for understanding the relationship between tone-deafness and developmental language disorders such as dyslexia. Here we show that phonemic awareness skills are positively correlated with pitch perception-production skills in children. Children between the ages of 7 and 9 were tested on pitch perception and production, phonemic awareness, and IQ. Results showed a significant positive correlation between pitch perception-production and phonemic awareness, suggesting that the relationship between musical and linguistic sound processing is intimately linked to awareness at the level of pitch and phonemes. Since tone-deafness is a pitch-related impairment and dyslexia is a deficit of phonemic awareness, we suggest that dyslexia and tone-deafness may have a shared and/or common neural basis.

  6. Challenges for immersion lithography extension based on negative tone imaging (NTI) process (United States)

    Shirakawa, Michihiro; Omatsu, Tadashi; Ou, Keiyu; Yonekuta, Yasunori; Hatakeyama, Naoya; Asakawa, Daisuke; Yakushiji, Takashi; Fujita, Mitsuhiro; Muraki, Nanae


    Negative tone imaging (NTI) process is a method for obtaining a negative-tone reversal pattern by developing with an organic solvent. As NTI process can break-through the resolution limit of a conventional positive tone development (PTD) process at specific pattern such as trenches and contact holes, it have been applied for a mass production in 20nm and 14nm nodes devices. In NTI system, because a developer is changed from a hydrophilic aqueous solution to a hydrophobic organic solvent, it is possible to review the common resist stack which is optimized for a PTD process. In this paper, we examined the possibility of a bi-layer process using a Si-containing NTI resist. Etching selectivity between the Si-NTI resist and a SOC improved by raising Si-content of the Si-NTI resist, but resolution deteriorates as a trade-off. By suppressing swelling behavior of the Si-NTI resist with a polymer structure control, we overcame this trade-off. As a result, in sub-90 nm pitch L/S and CH patterns, the resolution of the Si-NTI resist achieved comparable level to a conventional NTI resist. In addition, SOC etching was successfully carried out by using the Si-NTI resist pattern as an etching hard mask.

  7. Cortisol and vagal tone responses to competitive challenge in preschoolers: associations with temperament. (United States)

    Donzella, B; Gunnar, M R; Krueger, W K; Alwin, J


    Sixty-one 3- to 5-year-old nursery school children participated in a study of tempera ment and stress responses to competition. Each child individually participated in a competition against a familiar adult experimenter to determine who would win enough games to receive a prize. After initially winning three games (Win Period), the children lost the next three games (Lose Period), before winning the final games and receiving the prize. Salivary cortisol, vagal tone, affect and turn-taking behavior were measured in response to the competition and examined in relation to child temperament using a teacher-report version of the Child Behavior Questionnaire. Behavioral measures indicated that the procedures were emotionally engaging and the threat of losing was aversive. Surgency (extroversion) was positively correlated with positive affect during Win periods and tense/angry affect during the Lose period of the competition. Vagal tone decreased as the children began to play against the adult and children who were more tense/angry while losing showed additional suppression of vagal tone when they began to lose the competition. Most of the children did not show a cortisol response to the competition; however, the 15% who increased cortisol (responses >1 SD of classroom baselines) were described by teachers as more surgent and lower in effortful control. All but one of these children who increased in cortisol was male. Cortisol responsive children also displayed higher levels of tense/angry affect during the Lose period. Surgent, extroverted children appear to be vulnerable to competition stress.


    Institute of Scientific and Technical Information of China (English)

    张晓君; 赵毅; 高玉红; 耿稚萍; 余华峰


    Objective. To explore the changes of three-tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia.``Methods. Thirty-four patients of aging dementia underwent traditional P300 (2t-P300) and three-tone paradigm auditory P300 (3t-P300). The resuhs of these two methods were compared.Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9%) by 2t-P300, and in 26 of 30 patients who finished the 3t-P300 tests (86. 7% ). In 2t-P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2severe cases showed abnormal results. In 3t-P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t-P300 was found in 13 of 16 cases which showed normal 2t-P300. Besides prolonged and bad-shaped P300, no certain response of P300 to rare non-target stimulus (r-nT) was found in 10 mild cases by 3t-P300.``Conclusion. Three-tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r-nT in 3t-P300 is an important index in early diagnosis of mild dementia.

  9. Temporal coherence for pure tones in budgerigars (Melopsittacus undulatus) and humans (Homo sapiens). (United States)

    Neilans, Erikson G; Dent, Micheal L


    Auditory scene analysis has been suggested as a universal process that exists across all animals. Relative to humans, however, little work has been devoted to how animals perceptually isolate different sound sources. Frequency separation of sounds is arguably the most common parameter studied in auditory streaming, but it is not the only factor contributing to how the auditory scene is perceived. Researchers have found that in humans, even at large frequency separations, synchronous tones are heard as a single auditory stream, whereas asynchronous tones with the same frequency separations are perceived as 2 distinct sounds. These findings demonstrate how both the timing and frequency separation of sounds are important for auditory scene analysis. It is unclear how animals, such as budgerigars (Melopsittacus undulatus), perceive synchronous and asynchronous sounds. In this study, budgerigars and humans (Homo sapiens) were tested on their perception of synchronous, asynchronous, and partially overlapping pure tones using the same psychophysical procedures. Species differences were found between budgerigars and humans in how partially overlapping sounds were perceived, with budgerigars more likely to segregate overlapping sounds and humans more apt to fuse the 2 sounds together. The results also illustrated that temporal cues are particularly important for stream segregation of overlapping sounds. Lastly, budgerigars were found to segregate partially overlapping sounds in a manner predicted by computational models of streaming, whereas humans were not.

  10. Efficacy of three-tone disclosing agent as an adjunct in caries risk assessment

    Directory of Open Access Journals (Sweden)

    Mungara Jayanthi


    Full Text Available Background: Today, most approaches to caries viewed that catastrophic change in normal plaque biofilm is responsible for the disease. The behavior and composition of the biofilm are a reflection of the oral environment; the caries is a reflection of adverse changes occurring in that environment. Thus, it is important to identify the pathogenicity of the plaque biofilm so as to predict the caries risk. The recently developed three-tone plaque disclosing agent was used to test its ability in identifying the pathogenicity of plaque. Aim: To assess the efficacy of three-tone plaque disclosing agent in identifying the plaque pathogenicity and correlate with the clinical caries status and microbiological findings. Materials and Methods: Sixty children of 6-13 years age group of both sexes were clinically examined for caries and plaque scores, and then disclosing agent was applied; the color stained plaque samples were collected and cultured for microbiological assessment, and the data were analyzed based on the caries status of the children. Results: There was a significant difference between the pathological plaque of caries active and caries free group (P < 0.05. The pathological plaque scores and the total colony counts, Streptococcus counts and mutans streptococci counts increased with the increase in caries. Conclusion: Three-tone plaque disclosing agent was effective in identifying pathological plaque and can be used as one of the chairside adjuvants in caries risk assessment.

  11. Non-manuals and tones : a comparative perspective on suprasegmentals and spreading

    Directory of Open Access Journals (Sweden)

    Roland Pfau


    Full Text Available Sign languages, i.e. language in the visual-gestural modality, are known to make abundant use of grammatical non-manual markers (NMMs that fulfill functions at all linguistic levels. NMMs constitute a layer on top of the segmental layer, which consists of sequences of locations and movements, and they are capable of spreading over domains of varying size. Their suprasegmental nature as well as their ability to spread suggests a comparison to tones in tone languages, which may also function at the lexical, morphological, and syntactic level. In this paper, I offer a detailed comparison of the behavior of suprasegmentals in sign and spoken languages. I argue that they are functionally equivalent in the two modalities, but that non-manual spreading also displays some modality-specific properties. I tentatively claim that spreading of different types of NMMs targets prosodic domains of varying size: the prosodic word for lexical NMMs, the phonological phrase for morphological NMMs, and the intonational phrase for syntactic NMMs. In addition, I suggest that eye blinks function like boundary tones.

  12. Overnight fasting regulates inhibitory tone to cholinergic neurons of the dorsomedial nucleus of the hypothalamus.

    Directory of Open Access Journals (Sweden)

    Florian Groessl

    Full Text Available The dorsomedial nucleus of the hypothalamus (DMH contributes to the regulation of overall energy homeostasis by modulating energy intake as well as energy expenditure. Despite the importance of the DMH in the control of energy balance, DMH-specific genetic markers or neuronal subtypes are poorly defined. Here we demonstrate the presence of cholinergic neurons in the DMH using genetically modified mice that express enhanced green florescent protein (eGFP selectively in choline acetyltransferase (Chat-neurons. Overnight food deprivation increases the activity of DMH cholinergic neurons, as shown by induction of fos protein and a significant shift in the baseline resting membrane potential. DMH cholinergic neurons receive both glutamatergic and GABAergic synaptic input, but the activation of these neurons by an overnight fast is due entirely to decreased inhibitory tone. The decreased inhibition is associated with decreased frequency and amplitude of GABAergic synaptic currents in the cholinergic DMH neurons, while glutamatergic synaptic transmission is not altered. As neither the frequency nor amplitude of miniature GABAergic or glutamatergic postsynaptic currents is affected by overnight food deprivation, the fasting-induced decrease in inhibitory tone to cholinergic neurons is dependent on superthreshold activity of GABAergic inputs. This study reveals that cholinergic neurons in the DMH readily sense the availability of nutrients and respond to overnight fasting via decreased GABAergic inhibitory tone. As such, altered synaptic as well as neuronal activity of DMH cholinergic neurons may play a critical role in the regulation of overall energy homeostasis.

  13. Processing of acoustic and phonological information of lexical tones in Mandarin Chinese revealed by mismatch negativity. (United States)

    Yu, Keke; Wang, Ruiming; Li, Li; Li, Ping


    The accurate perception of lexical tones in tonal languages involves the processing of both acoustic information and phonological information carried by the tonal signal. In this study we evaluated the relative role of the two types of information in native Chinese speaker's processing of tones at a preattentive stage with event-related potentials (ERPs), particularly the mismatch negativity (MNN). Specifically, we distinguished the acoustic from the phonological information by manipulating phonological category and acoustic interval of the stimulus materials. We found a significant main effect of phonological category for the peak latency of MMN, but a main effect of both phonological category and acoustic interval for the mean amplitude of MMN. The results indicated that the two types of information, acoustic and phonological, play different roles in the processing of Chinese lexical tones: acoustic information only impacts the extent of tonal processing, while phonological information affects both the extent and the time course of tonal processing. Implications of these findings are discussed in light of neurocognitive processes of phonological processing.

  14. Effect of beta-adrenergic blockade on elevated arterial compliance and low systemic vascular resistance in cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Bendtsen, F; Henriksen, Jens Henrik Sahl


    with beta-blockers, but the effect of this treatment on arterial compliance has not been investigated. The aim of the present study was therefore to assess the effects of propranolol on the arterial compliance of patients with cirrhosis. METHODS: Twenty patients with cirrhosis underwent a haemodynamic......) of 17.8 mmHg, and responded to beta-blocker treatment with a significant reduction in the HVPG (-16%; P beta-adrenergic blockade (1.27 versus 1.29 ml/mmHg, +2%, ns), whereas...... with beta-blockers increases small vessel (arteriolar) vascular tone towards the normal level, but does not affect the elevated compliance of the larger arteries in patients with cirrhosis....

  15. Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP. (United States)

    Cravo, Sergio L; Campos, Ruy R; Colombari, Eduardo; Sato, Mônica A; Bergamaschi, Cássia M; Pedrino, Gustavo R; Ferreira-Neto, Marcos L; Lopes, Oswaldo U


    Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.

  16. Effet de taille dans le béton léger de polystyrène expansé


    MILED, K


    Il a été observé expérimentalement, dans la littérature, que la résistance du béton léger de polystyrène, à densité égale, diminue sensiblement lorsqu'on augmente la taille Ø des inclusions légères. L'objectif de cette thèse est l'identification de l'origine physique ainsi que la modélisation de cet effet de taille. Dans la première partie de ce travail, nous avons étudié les mécanismes de rupture et l'effet de taille dans un béton léger modèle 2D où les billes de polystyrène sont remplacées ...

  17. Effets des Chocs de Produits de Base sur la Mobilisation des Recettes Publiques dans les Pays d'Afrique Sub-saharienne


    DIARRA, Souleymane


    Les chocs de produits de base ont fait l’objet de nombreuses études scientifiques. Les analyses se sont plutôt concentrées sur l’effet des chocs sur : la croissance économique, les dépenses publiques, le niveau de la pauvreté des ménages, etc. Cet article donne une autre dimension à l’analyse de l’effet des chocs en s’intéressant à la mobilisation des recettes publiques dans les pays d’Afrique sub-saharienne. Nous avons d’abord identifié et créé des variables muettes «booms» et «busts». Le te...

  18. Renal Artery Stent Outcomes (United States)

    Murphy, Timothy P.; Cooper, Christopher J.; Matsumoto, Alan H.; Cutlip, Donald E.; Pencina, Karol M.; Jamerson, Kenneth; Tuttle, Katherine R.; Shapiro, Joseph I.; D’Agostino, Ralph; Massaro, Joseph; Henrich, William; Dworkin, Lance D.


    BACKGROUND Multiple randomized clinical trials comparing renal artery stent placement plus medical therapy with medical therapy alone have not shown any benefit of stent placement. However, debate continues whether patients with extreme pressure gradients, stenosis severity, or baseline blood pressure benefit from stent revascularization. OBJECTIVES The study sought to test the hypothesis that pressure gradients, stenosis severity, and/or baseline blood pressure affects outcomes after renal artery stent placement. METHODS Using data from 947 patients with a history of hypertension or chronic kidney disease from the largest randomized trial of renal artery stent placement, the CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) study, we performed exploratory analyses to determine if subsets of patients experienced better outcomes after stent placement than the overall cohort. We examined baseline stenosis severity, systolic blood pressure, and translesion pressure gradient (peak systolic and mean) and performed interaction tests and Cox proportional hazards analyses for the occurrence of the primary endpoint through all follow-up, to examine the effect of these variables on outcomes by treatment group. RESULTS There were no statistically significant differences in outcomes based on the examined variables nor were there any consistent nonsignificant trends. CONCLUSIONS Based on data from the CORAL randomized trial, there is no evidence of a significant treatment effect of the renal artery stent procedure compared with medical therapy alone based on stenosis severity, level of systolic blood pressure elevation, or according to the magnitude of the transstenotic pressure gradient. (Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions [CORAL]; NCT00081731) PMID:26653621

  19. Composition of connective tissues and morphometry of vascular smooth muscle in arterial wall of DOCA-salt hypertensive rats - In relation with arterial remodeling. (United States)

    Hayashi, Kozaburo; Shimizu, Emiko


    Hypertension (HT) was induced in Wistar rats aged 16 and 48 weeks by a deoxycortico-sterone acetate (DOCA)-salt procedure. Common carotid arteries were resected 16 weeks after, and their histological specimens were selectively stained for observations of collagen, elastin, and vascular smooth muscle (VSM) cells. Then, the fractions of collagen and elastin and their radial distributions, and the size and number of VSM cells were determined with an image analyzer. These results were compared with the results from age-matched, non-treated, normotensive (NT) animals and also with those from our previous biomechanical studies. In both age groups, there were no significant differences in the fractions of collagen and elastin, and the ratio of collagen to elastin content between HT and NT arteries. These results correspond well with our previous biomechanical results, which showed no significant difference in wall elasticity between HT and NT vessels. Moreover, in the innermost layer out of 4 layers bordered with thick elastic lamellae, the fraction of collagen was significantly greater in HT arteries than in NT ones, which is attributable to HT-related stress concentration in the layer. VSM cells were significantly hypertrophied and their content was increased by HT, although their total number in the media remained unchanged. The increased size and content of cells correspond to the enhancement of vascular tone and contractility in HT arteries.

  20. High- and Low-Frequency Probe Tone Tympanometry in Chinese Infants

    Institute of Scientific and Technical Information of China (English)


    Objective To assess the utility of low- and high-frequency tympanometry in the diagnosis of middle ear dysfunction in Chinese infants. Methods Tympanograms were obtained with 226 Hz, 678 Hz and 1000 Hz probe tones from infants aged 5-25 weeks with normal auditory brainstem responses (ABRs)(15 infants,30 ears) and withprolonged wave Ⅰ latencies(17 infants, 20 ears), suggesting middle ear dysfunction, using a GSI Tympstar middle ear analyzer Version Ⅱ. Results The single-peaked tympanogram was the most characteristic type in both groups and seen in 25 ears (83.3%) in the normal ABR group and in 18 ears (90%) in the delayed wave Ⅰ group, respectively. The peak pressure, peak compensated static acoustic admittance and gradient of 226 Hz tympanometry were of no significant differences between the two groups. The 678 Hz tympanograms of admittance, susceptance and conductance demonstrated non-peak, single-, double- and tri-peaked patterns in both groups. The agreement between ABRs and 678 Hz tympanograms of admittance,susceptance and conductance were 70.0%, 58.0% and 64.0%(kappa=0.324, 0.234 and 0.118) respectively. For 1000 Hz probe tone, admittance,susceptance and conductance tympanograms showed single peaked patterns in 28 (93.3%), 25 (83.3%) and 26 (86.7%) of the 30 normal ears. Admittance, susceptance and conductance tympanograms using the 1000 Hz probe tone were flat in 15 (75%), 17(85%) and 13 (65%) of the ears in infants with prolonged wave Ⅰ latencies. For 1000 Hz admittance, susceptance and conductance Tympanograms, the agreement between tympanometry and ABR results were 90.0%, 92.0% and 86.0% with kappa at 0.783, 0.831 and 0.690, respectively. Conclusion 1000 Hz probe tone tympanometry is a promising middle ear function test for infants of 1-6 months age, while 226 Hz and 678 Hz probe tones are less efficient in detecting middle ear dysfunction in infants.

  1. 降调的种类%A Classification of Falling Tones

    Institute of Scientific and Technical Information of China (English)



    Although the falling tone is the commonest contour type in tone languages, its distinctive types have never been seriously studied before. This paper examines falling tone types in the Multi-Register and Four-Level tonal model with four parameters: register, length, pitch height and contour. First, a category of 'pure low tone' (PLT) is set up. It includes various contours sharing the same distinctive feature of [+low]: low falling, low level, low dipping, low rising, and creaky dipping. Then six Rg M falling tone types are identified: high falling, low falling, slight falling, short falling, delayed falling and depressed falling. Four of them also occur in Rg L: high falling with creaky voice, delayed falling with slack voice, depressed falling with slack voice, and low falling with slack voice. Five pairs of distinctive features are called for in classifying falling tones: [±RgM], [±straight], [±long], [±high] and [±slop]. There are at most three falling tones in a single register and up to four in two registers.%降调是声调系统中最为常见的拱形,可对它的区别性类型从未有过全面深入的研究。本文以调域、长度、高度、拱度四参数声调模型来考察降调类型。首先提出一个"纯低调"的调型概念,涵盖低降、低平、低凹、低升、嘎裂凹调等以[+low]为区别特征的拱形。然后辨认出六型出现在中域的降调拱形:高降、低降、微降、短降、高弯降和低凸降。其中四型还出现于低域:弛声高长凸降(弯降变体)、弛声低短凸降、弛声低降、嘎裂高降。用于区分降调的区别特征有五对:调域[±RgM],拱度[±直],长度[±长],高度[±高],再拱度[±斜]。单域中最多三个降调,双域中可有四个降调。

  2. Case Report: Coronary arterial spasm in single right coronary artery

    Institute of Scientific and Technical Information of China (English)

    En-zhi JIA; Qi-jun SHAN; Zhi-jian YANG; Tie-bing ZHU; Lian-sheng WANG; Ke-jiang CAO; Wen-zhu MA


    We presented a case of anomalous single-coronary artery detected incidentally during routine coronary angiography. A 32-year-old male Chinese patient presented with recurrent pre-syncope and six episodes of syncope. Coronary angiography and coronary-computed tomography (CT)-angiography performed by a dual-source computed tomography (DSCT) revealed that the patient had a single large right coronary artery. A moderately large branch originated from the proximal part of the single right coronary artery and extended to the left, passing the anterior to the pulmonary artery, and divided into the anterior descending artery branch and circumflex branch at the base of the left auricular appendage. The episodes of the syncope were suspected to be caused by coronary arterial spasm, so this patient was on a regimen of 30 mg of diltiazem every 6 h and had no recurrence of syncope during follow-up.


    Institute of Scientific and Technical Information of China (English)



    This study investigated the efficacy of the Task-based instruction for improving students' understanding and awareness of stress and tone.23 learners made up the control group to receive the traditional method as opposed to 23 learners who receive the task-based instruction to teach stress and tone. The results indicated statistically significant differences between the Control and Experimental groups on the variables of post test scores.

  4. Massive cerebral arterial air embolism following arterial catheterization

    Energy Technology Data Exchange (ETDEWEB)

    Yang, C.W. [Northwestem University Feinberg School of Medicine, Department of Radiology, Chicago, IL (United States); Yang, B.P. [Northwestern University Feinberg School of Medicine, Department of Neurological Surgery, Chicago, IL (United States)


    Microscopic cerebral arterial air embolism (CAAE) has been described in many patients undergoing cardiac surgery as well as other invasive diagnostic and therapeutic procedures. However, massive CAAE is rare. We report a 42-year-old woman who initially presented with thalamic and basal ganglia hemorrhages. Shortly after a radial arterial catheter was inserted, the patient suffered a generalized seizure and CT demonstrated intra-arterial air in bilateral cerebral hemispheres. (orig.)

  5. Computer-aided assessment of tone production: A case of Zimbabwean students learning Chinese as a foreign language

    Directory of Open Access Journals (Sweden)

    Herbert Mushangwe


    Full Text Available This study examined how technology can help in assessing and teaching Chinese tones to foreign students who are not used to tonal languages. It was an attempt to show how we can use the PRAAT software to make learners of Chinese as a foreign language realize their tonal errors. The data used was collected from the students at the University of Zimbabwe studying Chinese and this was part of a continuous assessment for the students’ pronunciation of Chinese tones. This method which was used by teachers to assess students’ tones was found to be easy to follow such that students could also utilize it for their own pronunciation practice. We argued that the use of computer-aided assessment makes assessment of students’ tone acquisition lesser arbitrary than when the teacher merely gives comments based on his or her individual perception. This is because this assessment method gives PRAAT acoustic pictures which show the tone structures for each student; hence, both the student and the teacher can visualize the errors. Since PRAAT can provide a platform to compare the student’s pronunciation with that of the native speaker and at the same time can help the teacher to explain why student’s pronunciation is wrong, this paper concludes that PRAAT can be a useful tool in assessing and teaching Chinese tones.

  6. Individual differences in processing pitch contour and rise time in adults: A behavioral and electrophysiological study of Cantonese tone merging. (United States)

    Ou, Jinghua; Law, Sam-Po


    One way to understand the relationship between speech perception and production is to examine cases where the two dissociate. This study investigates the hypothesis that perceptual acuity reflected in event-related potentials (ERPs) to rise time of sound amplitude envelope and pitch contour [reflected in the mismatch negativity (MMN)] may associate with individual differences in production among speakers with otherwise comparable perceptual abilities. To test this hypothesis, advantage was taken of an on-going sound change-tone merging in Cantonese, and compared the ERPs between two groups of typically developed native speakers who could discriminate the high rising and low rising tones with equivalent accuracy but differed in the distinctiveness of their production of these tones. Using a passive oddball paradigm, early positive-going EEG components to rise time and MMN to pitch contour were elicited during perception of the two tones. Significant group differences were found in neural responses to rise time rather than pitch contour. More importantly, individual differences in efficiency of tone discrimination in response latency and magnitude of neural responses to rise time were correlated with acoustic measures of F0 offset and rise time differences in productions of the two rising tones.

  7. Arterial stiffness as a risk factor for coronary artery disease. (United States)

    Liao, Josh; Farmer, John


    Hypertension is a major modifiable risk factor, and clinical trials have demonstrated that successful reduction of elevated blood pressure to target levels translates into decreased risk for the development of coronary artery disease, stroke, heart failure, and renal failure. The arterial system had previously been regarded as a passive conduit for the transportation of arterial blood to peripheral tissues. The physiologic role the arterial system was greatly expanded by the recognition of the central role of the endothelial function in a variety of physiologic processes. The role of arterial function and structure in cardiovascular physiology was expanded with the development of a variety of parameters that evaluate arterial stiffness. Markers of arterial stiffness have been correlated with cardiovascular outcomes, and have been classified as an emerging risk factor that provides prognostic information beyond standard stratification strategies involving hypertension, diabetes, obesity, dyslipidemia and smoking. Multiple epidemiologic studies have correlated markers of arterial stiffness such as pulse-wave velocity, augmentation index and pulse pressure with risk for the development of fatal and nonfatal cardiovascular events. Additionally, measurements of arterial stiffness had clarified the results of clinical trials that demonstrated differing impacts on clinical outcomes, despite similar reductions in blood pressure, as measured by brachial and sphygmomanometry.

  8. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons (United States)

    Fleury, G.


    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  9. Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, F. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires


    Amongst the lesions brought about by total body irradiation, two basically different types can be distinguished: those appearing in the area which has absorbed radiant energy and those emerging in areas remote from the irradiated tissues (abscopal effects). The abscopal effects are produced by toxic tissue breakdown products, which are removed by the bloodstream and interfere with particularly sensitive structures (radiotoxins). The radiotoxins mobilize other biologically active substances, interfering with the same tissues which may display abscopal effects. This is well established for the hormones of the adrenal cortex. Furthermore, important fractions of the radiotoxins are neutralized by the reticuloendothelial system. Temporary blockade of this system enhances the efficiency of radiotoxins and greatly increases mortality of the irradiated animals. One can therefore conclude that the reticuloendothelial system affords a natural defense against an essential reaction of total body irradiation: the effect of the radiotoxins. (author) [French] Les lesions consecutives a une irradiation peuvent etre classees en deux categories: celles qui se produisent au niveau du tissu irradie et celles qui apparaissent en dehors de celui-ci. Ces dernieres - appelees -'effets a distance'- sont dues a l'action de produits d'histolyse apparaissant au niveau du volume tissulaire ayant absorbe l'energie radiante, emportes par le courant sanguin et agissant sur des structures specialement receptives (Radiotoxines). Ces corps provoquait, dans des structures eloignees du siege de l'action locale du rayonnement, la secretion d'autres corps biologiquement actifs, capables d'agir sur les memes tissus pouvant presenter des effets a distance, compliquant ainsi leur mecanisme. Ceci est etabli pour les corticosteroides. De plus, des fractions importantes des radiotoxines sont neutralisees par le systeme reticuloendothelial. Puisque le blocage de ce

  10. Mechanisms of acetylcholine-mediated vasodilation in systemic arteries from mourning doves (Zenaida macroura). (United States)

    Jarrett, Catherine; Lekic, Mateja; Smith, Christina L; Pusec, Carolina M; Sweazea, Karen L


    For mammals, acetylcholine (ACh) promotes endothelium-dependent vasodilation primarily through nitric oxide (NO) and prostaglandin-mediated pathways, with varying reliance on endothelial-derived hyperpolarizing factors. Currently, no studies have been conducted on small systemic arteries from wild birds. We hypothesized that ACh-mediated vasodilation of isolated small arteries from mourning doves (Zenaida macroura) would likewise depend on endothelial-derived factors. Small resistance mesenteric and cranial tibial (c. tibial) arteries (80-150 μm, inner diameter) were cannulated and pre-constricted to 50 % of resting inner diameter with phenylephrine then exposed to increasing concentrations of ACh (10(-9)-10(-5) M) or the NO donor, sodium nitroprusside (SNP; 10(-12)-10(-3) M). For mesenteric arteries, ACh-mediated vasodilation was significantly blunted with the potassium channel antagonist tetraethylammonium chloride (TEA, 10 mM); whereas responses were only moderately impaired with endothelial disruption or inhibition of prostaglandins (indomethacin, 10 μM). In contrast, endothelial disruption as well as exposure to TEA largely abolished vasodilatory responses to ACh in c. tibial arteries while no effect of prostaglandin inhibition was observed. For both vascular beds, responses to ACh were moderately dependent on the NO signaling pathway. Inhibition of NO synthase had no impact, despite complete reversal of phenylephrine-mediated tone with SNP, whereas inhibition of soluble guanylate cyclase (sGC) caused minor impairments. Endothelium-independent vasodilation also relied on potassium channels. In summary, ACh-mediated vasodilation of mesenteric and c. tibial arteries occurs through the activation of potassium channels to induce hyperpolarization with moderate reliance on sGC. Prostaglandins likewise play a small role in the vasodilatory response to ACh in mesenteric arteries.

  11. Arterial responses during migraine headache

    DEFF Research Database (Denmark)

    Iversen, Helle Klingenberg; Nielsen, T H; Olesen, J


    The superficial temporal artery has been thought to be the main focus of pain during migraine attacks, but its diameter has never been measured directly. The use of a new, high-resolution ultrasound machine to measure arterial size in 25 migraine patients with unilateral head pain showed...... that the lumen was wider on the painful than on the non-painful side during a migraine attack. The diameters of both radial arteries and the temporal artery on the non-painful side were smaller during than between attacks. The generalised vasoconstriction was not shared by the temporal artery on the affected...... side, which suggests a local vasodilatory response. The findings suggest that cephalic arteries may play a role in migraine pathogenesis....

  12. True aneurysm of brachial artery. (United States)

    Hudorović, Narcis; Lovričević, Ivo; Franjić, Dario Bjorn; Brkić, Petar; Tomas, Davor


    True upper extremity peripheral artery aneurysms are a rarely encountered arterial disorder. Following computer-tomography angiographic (CT-a) imaging examination, true saccular aneurysm, originating from the left brachial artery was diagnosed in the 77-year-old female without history of trauma. The aneurysm was resected by surgical intervention, and primary repair of the brachial artery was performed by interposition of a part of great saphenous vein harvested from the left groin and creation of two end-to-end anastomoses between interposition graft and previously resected part of brachial artery. No complication was observed during the follow-up. Surgical intervention for upper extremity aneurysms should be initiated without delay. Factors combined with minimal morbidity associated with repair suggest that surgical repair should be performed routinely for true upper extremity arterial aneurysms.

  13. Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS

    Directory of Open Access Journals (Sweden)

    Aldo Gerbino


    Full Text Available Full-term human umbilical cord contains three blood vessels: two arteries coiled around a vein and surrounded by Wharton’s jelly, a mucous tissue with few mesenchymal stromal cells and abundant extracellular matrix. Umbilical vessels lack innervations, thus endothelial cells must play a role in the control of blood flow. The aim of this study was to investigate in human umbilical cord the expression of five peptides that could be involved in the regulation of vascular tone: Orphanin FQ, Oxytocin, Atrial Natriuretic Peptide (ANP, endothelial Nitric Oxide Synthase (eNOS and inducible Nitric Oxide Synthase (iNOS. The expression of these molecules in full-term human umbilical cord was investigated through immunohistochemistry and RT-PCR. Immunoreactivity for Orphanin FQ was detected in Wharton’s jelly, vessel musculature and endothelium; Oxytocin, ANP and eNOS were expressed by the umbilical epithelium, Wharton’s jelly and endothelium, whereas iNOS only by endothelial cells. RT-PCR analysis showed transcriptional expression of Oxytocin, ANP and eNOS mRNAs. The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord. mRNA expression for Oxytocin, ANP and eNOS suggest that these molecules are synthesized by umbilical cord cells themselves. The expression of these vasoactive molecules could be part of a general mechanism locally regulating vascular tone. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 211–218

  14. Age, hypertension and arterial function. (United States)

    McEniery, Carmel M; Wilkinson, Ian B; Avolio, Albert P


    1. Ageing exerts a marked effect on the cardiovascular system and, in particular, the large arteries. Using a variety of techniques to assess arterial stiffness, many cross-sectional studies have demonstrated a significant relationship between age and aortic stiffness, although the age-related changes observed in peripheral arteries appear to be less marked. 2. The relationship between arterial stiffness and hypertension is more complex. The distending, or mean arterial, pressure is an important confounder of measurements of arterial stiffness and, therefore, must be taken into consideration when assessing arterial stiffness in hypertensive subjects or investigating the effect of antihypertensive agents. Current methods for correcting for differences in distending pressure involve pharmacological manipulation, statistical correction or mathematical manipulation of stiffness indices. 3. Many studies have provided evidence that both peripheral (muscular) and central (elastic) arteries are stiffer in subjects with mixed (systolic/diastolic) hypertension compared with normotensive subjects. However, it is unclear to what extent differences in mean arterial pressure explain the observed differences in hypertensive subjects. In contrast, isolated systolic hypertension is associated with increased aortic, but not peripheral artery, stiffness, although the underlying mechanisms are somewhat unclear. 4. Traditional antihypertensive agents appear to reduce arterial stiffness, but mostly via an indirect effect of lowering mean pressure. Therefore, therapies that target the large arteries to reduce stiffness directly are urgently required. Agents such as nitric oxide donors and phosphodiesterase inhibitors may be useful in reducing stiffness via functional mechanisms. In addition, inhibitors or breakers of advanced glycation end-product cross-links between proteins, such as collagen and elastin, hold substantial promise.

  15. The right hepatic artery syndrome

    Institute of Scientific and Technical Information of China (English)

    Kazumi Miyashita; Katsuya Shiraki; Takeshi Ito; Hiroki Taoka; Takeshi Nakano


    Various benign and malignant conditions could cause biliary obstruction. Compression of extrahepatic bile duct (EBD) by right hepatic artery was reported as a right hepatic artery syndrome but all cases were compressed EBD from stomach side. Our case compressed from dorsum was not yet reported, so it was thought to be a very rare case. We present here the first case of bile duct obstruction due to the compression of EBD from dorsum by right hepatic artery.

  16. Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.

    Directory of Open Access Journals (Sweden)

    Ed VanBavel

    Full Text Available Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, thereby altering the contribution of shear-dependent dilation to the vascular tone. In addition, acute responses change the stimulus for structural adaptation and vice versa. Such control loops are able to maintain resistance vessels in a functional and stable state, characterized by regulated wall stress, shear stress, matched active and passive biomechanics and presence of vascular reserve. In this modeling study, four adaptation processes are identified that together with biomechanical properties effectuate such integrated regulation: control of tone, smooth muscle cell length adaptation, eutrophic matrix rearrangement and trophic responses. Their combined action maintains arteries in their optimal state, ready to cope with new challenges, allowing continuous long-term vasoregulation. The exclusion of any of these processes results in a poorly regulated state and in some cases instability of vascular structure.

  17. Countercurrent aortography via radial artery

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Hyung Kuk; Lee, Young Chun; Lee, Seung Chul; Jeon, Seok Chol; Joo, Kyung Bin; Lee, Seung Ro; Kim, Soon Yong [College of Medicine, Hanyang University, Seoul (Korea, Republic of)


    Countercurrent aortography via radial artery was performed for detection of aortic arch anomalies in 4 infants with congenital heart disease. Author's cases of aortic arch anomalies were 3 cases of PDA, 1 case of coarctation of aorta, and 1 case of occlusion of anastomosis site on subclavian artery B-T shunt. And aberrant origin of the right SCA, interrupted aortic arch, hypoplastic aorta, anomalous origin of the right pulmonary artery from the ascending aorta can be demonstrated by this method. Countercurrent aortography affords an safe and simple method for detection of aortic arch anomalies without retrograde arterial catheterization, especially in small infants or premature babies.

  18. Arterial Abnormalities Leading to Tinnitus. (United States)

    Miller, Timothy R; Serulle, Yafell; Gandhi, Dheeraj


    Tinnitus is a common symptom that usually originates in the middle ear. Vascular causes of pulsatile tinnitus are categorized by the location of the source of the noise within the cerebral-cervical vasculature: arterial, arteriovenous, and venous. Arterial stenosis secondary to atherosclerotic disease or dissection, arterial anatomic variants at the skull base, and vascular skull base tumors are some of the more common causes of arterial and arteriovenous pulsatile tinnitus. Noninvasive imaging is indicated to evaluate for possible causes of pulsatile tinnitus, and should be followed by catheter angiography if there is a strong clinical suspicion for a dural arteriovenous fistula.

  19. Pulmonary arterial hypertension in pregnancy. (United States)

    Običan, Sarah G; Cleary, Kirsten L


    Pulmonary hypertension is a medical condition characterized by elevated pulmonary arterial pressure and secondary right heart failure. Pulmonary arterial hypertension is a subset of pulmonary hypertension, which is characterized by an underlying disorder of the pulmonary arterial vasculature. Pulmonary hypertension can also occur secondarily to structural cardiac disease, autoimmune disorders, and toxic exposures. Although pregnancies affected by pulmonary hypertension and pulmonary arterial hypertension are rare, the pathophysiology exacerbated by pregnancy confers both high maternal and fetal mortality and morbidity. In light of new treatment modalities and the use of a multidisciplinary approach to care, maternal outcomes may be improving.

  20. [Hearing disorders in obliteration of the carotid artery. 2. Contribution to hearing loss in the aged]. (United States)

    Böhme, G


    Otologic-audiologic examination was carried out in 75 patients (between 42 and 86 years of age; average age: 65 years) with confirmed internal angiologic obliteration of the carotid artery, either unilateral or bilateral. There were 51 unilateral and 24 bilateral stenoses/occlusions. Diseases of the ear were excluded clinically and audiologically. - The mean hearing loss shows a sensorineural high tone loss in the tone audiogram. The range of scatter of high tone loss increases proportionally to the increase of frequency. - Compared with the physiological examination of geriatric patients, the total word comprehension and especially the minimal discrimination loss point towards a pathologic impairment of hearing. The total word comprehension amounts to 250.79% in the 51-60 age group, 237.79% in the 61-70 age group, 175.83% in persons aged 71-80 years, and 118.33% for those over 80 years of age. The minimal discrimination loss comprises 5.83% in the 51-60 age group, 9.79% in the 61-70 age group, 22.50% in patients between 71 and 80 years, and 48.00% in those over 80 years. - No connection between the extent of loss of hearing and the stage of obliteration of the carotid artery can be shown. However, the decompensation of total word comprehension and especially the minimal discrimination loss is a very important sign. - These findings contribute towards a differentiation of physiologic and pathologic hearing diseases in old age with particulas reference to the underlying arteriosclerotic disease.

  1. Berlyne Revisited: Evidence for the Multifaceted Nature of Hedonic Tone in the Appreciation of Paintings and Music (United States)

    Marin, Manuela M.; Lampatz, Allegra; Wandl, Michaela; Leder, Helmut


    In his seminal book on esthetics, Berlyne (1971) posited an inverted-U relationship between complexity and hedonic tone in arts appreciation, however, converging evidence for his theory is still missing. The disregard of the multidimensionality of complexity may explain some of the divergent results. Here, we argue that definitions of hedonic tone are manifold and systematically examined whether the nature of the relationship between complexity and hedonic tone is determined by the specific measure of hedonic tone. In Experiment 1, we studied three picture categories with similar affective and semantic contents: 96 affective environmental scenes, which were also converted into 96 cartoons, and 96 representational paintings. Complexity varied along the dimension of elements. In a between-subjects design, each stimulus was presented for 5 s to 206 female participants. Subjective ratings of hedonic tone (either beauty, pleasantness or liking), arousal, complexity and familiarity were collected in three conditions per stimulus set. Complexity and arousal were positively associated in all conditions, with the strongest association observed for paintings. For environmental scenes and cartoons, there was no significant association between complexity and hedonic tone, and the three measures of hedonic tone were highly correlated (all rs > 0.85). As predicted, in paintings the measures of hedonic tone were less strongly correlated (all rs > 0.73), and when controlling for familiarity, the association with complexity was significantly positive for beauty (rs = 0.26), weakly negative for pleasantness (rs = -0.16) and not present for liking. Experiment 2 followed a similar approach and 77 female participants, all non-musicians, rated 92 musical excerpts (15 s) in three conditions of hedonic tone (either beauty, pleasantness or liking). Results indicated a strong relationship between complexity and arousal (all rs > 0.85). When controlling for familiarity effects, the

  2. Berlyne revisited: Evidence for the multifaceted nature of hedonic tone in the appreciation of paintings and music

    Directory of Open Access Journals (Sweden)

    Manuela Maria Marin


    Full Text Available In his seminal book on aesthetics, Berlyne (1971 posited an inverted-U relationship between complexity and hedonic tone in arts appreciation, however, converging evidence for his theory is still missing. The disregard of the multidimensionality of complexity may explain some of the divergent results. Here, we argue that definitions of hedonic tone are manifold and systematically examined whether the nature of the relationship between complexity and hedonic tone is determined by the specific measure of hedonic tone. In Experiment 1, we studied three picture categories with similar affective and semantic contents: 96 affective environmental scenes, which were also converted into 96 cartoons, and 96 representational paintings. Complexity varied along the dimension of elements. In a between-subjects design, each stimulus was presented for 5 s to 206 female participants. Subjective ratings of hedonic tone (either beauty, pleasantness or liking, arousal, complexity and familiarity were collected in three conditions per stimulus set. Complexity and arousal were positively associated in all conditions, with the strongest association observed for paintings. For environmental scenes and cartoons, there was no significant association between complexity and hedonic tone, and the three measures of hedonic tone were highly correlated (all rs >.85. As predicted, in paintings the measures of hedonic tone were less strongly correlated (all rs >.73, and when controlling for familiarity, the association with complexity was significantly positive for beauty (rs = .26, weakly negative for pleasantness (rs = -.16 and not present for liking. Experiment 2 followed a similar approach and 77 female participants, all non-musicians, rated 92 musical excerpts (15 s in three conditions of hedonic tone (either beauty, pleasantness or liking. Results indicated a strong relationship between complexity and arousal (all rs >.85. When controlling for familiarity effects, the

  3. [Measurement of arterial pressure]. (United States)

    Rorive, G


    The casual determination of blood pressure remains the basis of the diagnosis of arterial hypertension and the criteria for usefulness of drug therapy. The reference values usually in use concern determinations by the doctor in very well defined conditions, rest, size of the bladder, etc.... The poor reproductibility of the determinations made by the doctor in casual conditions has produced a large interest for new approaches: autodetermination by the patient at home, and ambulatory blood pressure determinations using automatic devices. These new approaches have their own reference values, specific indications and limitations.

  4. Les effets musculaires de la vitamine D : application à la perte musculaire liée à l’âge

    Directory of Open Access Journals (Sweden)

    Walrand Stéphane


    Full Text Available Au-delà de ses rôles biologiques classiques sur la santé osseuse, les effets extra-squelettiques de la vitamine D font actuellement l’objet de nombreuses recherches. La présence du récepteur de la vitamine D dans la plupart des tissus de l’organisme vient d’ailleurs renforcer l’argument en faveur de ses fonctions multiples. Parmi celles-ci, l’effet de la vitamine D sur la masse et les performances musculaires a été longtemps pressenti. En effet, dans la Grèce Antique, Hérodote recommandait le soleil comme un remède pour les « muscles faibles et mous », et les anciens Olympiens recevaient l’ordre de se coucher exposés aux rayons du soleil pour améliorer leurs performances physiques. En 1952, Spellerberg, un physiologiste du sport, a réalisé une vaste étude portant sur les effets de l’irradiation UV sur les performances d’athlètes de haut niveau. Suite aux résultats positifs de cette investigation, ce scientifique dû informer le Comité Olympique que l’irradiation UV présentait un effet « convaincant » sur la performance physique et les capacités motrices. Ces données sont conformes à de nombreuses études postérieures signalant une amélioration des aptitudes physiques, de la vitesse et de l’endurance chez des sujets jeunes traités par des UV ou par des suppléments contenant de la vitamine D. Des observations complémentaires font état d’un effet significatif sur la force musculaire, en particulier au niveau des membres inférieurs. Concernant les mécanismes mis en jeu, certaines études fondamentales récentes ont montré que la vitamine D exerce des effets moléculaires au sein de la cellule musculaire. Précisément, une action régulatrice de la vitamine D sur les flux de calcium, l’homéostasie minérale et certaines voies de signalisation contrôlant l’anabolisme protéique a été rapportée au niveau du tissu musculaire. Plusieurs enquêtes épidémiologiques révèlent qu

  5. Lipreading and covert speech production similarly modulate human auditory-cortex responses to pure tones. (United States)

    Kauramäki, Jaakko; Jääskeläinen, Iiro P; Hari, Riitta; Möttönen, Riikka; Rauschecker, Josef P; Sams, Mikko


    Watching the lips of a speaker enhances speech perception. At the same time, the 100 ms response to speech sounds is suppressed in the observer's auditory cortex. Here, we used whole-scalp 306-channel magnetoencephalography (MEG) to study whether lipreading modulates human auditory processing already at the level of the most elementary sound features, i.e., pure tones. We further envisioned the temporal dynamics of the suppression to tell whether the effect is driven by top-down influences. Nineteen subjects were presented with 50 ms tones spanning six octaves (125-8000 Hz) (1) during "lipreading," i.e., when they watched video clips of silent articulations of Finnish vowels /a/, /i/, /o/, and /y/, and reacted to vowels presented twice in a row; (2) during a visual control task; (3) during a still-face passive control condition; and (4) in a separate experiment with a subset of nine subjects, during covert production of the same vowels. Auditory-cortex 100 ms responses (N100m) were equally suppressed in the lipreading and covert-speech-production tasks compared with the visual control and baseline tasks; the effects involved all frequencies and were most prominent in the left hemisphere. Responses to tones presented at different times with respect to the onset of the visual articulation showed significantly increased N100m suppression immediately after the articulatory gesture. These findings suggest that the lipreading-related suppression in the auditory cortex is caused by top-down influences, possibly by an efference copy from the speech-production system, generated during both own speech and lipreading.

  6. Intracellular responses to frequency modulated tones in the dorsal cortex of the mouse inferior colliculus

    Directory of Open Access Journals (Sweden)

    Ruediger eGeis


    Full Text Available Frequency modulations occur in many natural sounds, including vocalizations. The neuronal response to frequency modulated (FM stimuli has been studied extensively in different brain areas, with an emphasis on the auditory cortex and the central nucleus of the inferior colliculus. Here, we measured the responses to FM sweeps in whole-cell recordings from neurons in the dorsal cortex of the mouse inferior colliculus. Both up- and downward logarithmic FM sweeps were presented at two different speeds to both the ipsi- and the contralateral ear. Based on the number of action potentials that were fired, between 10-24% of cells were selective for rate or direction of the FM sweeps. A somewhat lower percentage of cells, 6-21%, showed selectivity based on EPSP size. To study the mechanisms underlying the generation of FM selectivity, we compared FM responses with responses to simple tones in the same cells. We found that if pairs of neurons responded in a similar way to simple tones, they generally also responded in a similar way to FM sweeps. Further evidence that FM selectivity can be generated within the dorsal cortex was obtained by reconstructing FM sweeps from the response to simple tones using three different models. In about half of the direction selective neurons the selectivity was generated by spectrally asymmetric synaptic inhibition. In addition, evidence for direction selectivity based on the timing of excitatory responses was also obtained in some cells. No clear evidence for the local generation of rate selectivity was obtained. We conclude that FM direction selectivity can be generated within the dorsal cortex of the mouse inferior colliculus by multiple mechanisms.

  7. Modulation of cardiac autonomic tone in non-hypotensive hypovolemia during blood donation. (United States)

    Yadav, Kavita; Singh, Akanksha; Jaryal, Ashok Kumar; Coshic, Poonam; Chatterjee, Kabita; Deepak, K K


    Non-hypotensive hypovolemia, observed during mild haemorrhage or blood donation leads to reflex readjustment of the cardiac autonomic tone. In the present study, the cardiac autonomic tone was quantified using heart rate and blood pressure variability during and after non-hypotensive hypovolemia of blood donation. 86 voluntary healthy male blood donors were recruited for the study (age 35 ± 9 years; weight 78 ± 12 kg; height 174 ± 6 cms). Continuous lead II ECG and beat-to-beat blood pressure was recorded before, during and after blood donation followed by offline time and frequency domain analysis of HRV and BPV. The overall heart rate variability (SDNN and total power) did not change during or after blood donation. However, there was a decrease in indices that represent the parasympathetic component (pNN50 %, SDSD and HF) while an increase was observed in sympathetic component (LF) along with an increase in sympathovagal balance (LF:HF ratio) during blood donation. These changes were sustained for the period immediately following blood donation. No fall of blood pressure was observed during the period of study. The blood pressure variability showed an increase in the SDNN, CoV and RMSSD time domain measures in the post donation period. These results suggest that mild hypovolemia produced by blood donation is non-hypotensive but is associated with significant changes in the autonomic tone. The increased blood pressure variability and heart rate changes that are seen only in the later part of donation period could be because of the progressive hypovolemia associated parasympathetic withdrawal and sympathetic activation that manifest during the course of blood donation.

  8. Auditory brainstem responses to clicks and tone bursts in C57 BL/6J mice. (United States)

    Scimemi, P; Santarelli, R; Selmo, A; Mammano, F


    In auditory research, hearing function of mouse mutants is assessed in vivo by evoked potential recording. Evaluation of the response parameters should be performed with reference to the evoked responses recorded from wild-type mice. This study reports normative data calculated on auditory brainstem responses (ABRs) obtained from 20 wild-type C57 BL/6J mice at a postnatal age between 21 and 45 days. Acoustic stimuli consisted tone bursts at 8, 14, 20, 26, 32 kHz, and clicks. Each stimulus was delivered in free field at stimulation intensity starting from a maximum of 100 dB peak equivalent SPL (dB peSPL) at decreasing steps of 10 dB with a repetition rate of 13/sec. Evoked responses were recorded by needle electrodes inserted subcutaneously. At high intensity stimulation, five response waveforms, each consisting of a positive peak and a subsequent negative valley, were identified within 7 msec, and were labelled with sequential capital Roman numerals from I to V. Peak IV was the most robust and stable at low intensities for both tone burst and click stimuli, and was therefore utilized to estimate hearing thresholds. Both latencies and amplitudes of ABR peaks showed good reproducibility with acceptable standard deviations. Mean wave IV thresholds measured across all animals ranged from a maximum of 23 dB peSPL for clicks to a minimum of 7 dB peSPL for 20 kHz-tone burst stimuli. Statistical analysis of the distribution of latencies and amplitudes of peaks from I to V performed for each stimulus type yielded a normative data set which was utilised to obtain the most consistent fitting-curve model. This could serve as a reference for further studies on murine models of hearing loss.

  9. Numerical simulation of the generation mechanism of axisymmetric supersonic jet screech tones (United States)

    Li, X. D.; Gao, J. H.


    In this paper an axisymmetric computational aeroacoustic procedure is developed to investigate the generation mechanism of axisymmetric supersonic jet screech tones. The axisymmetric Navier-Stokes equations and the two equations standard k-ɛ turbulence model modified by Turpin and Troyes ["Validation of a two-equation turbulence model for axisymmetric reacting and non-reaction flows," AIAA Paper No. 2000-3463 (2000)] are solved in the generalized curvilinear coordinate system. A generalized wall function is applied in the nozzle exit wall region. The dispersion-relation-preserving scheme is applied for space discretization. The 2N storage low-dissipation and low-dispersion Runge-Kutta scheme is employed for time integration. Much attention is paid to far-field boundary conditions and turbulence model. The underexpanded axisymmetric supersonic jet screech tones are simulated over the Mach number from 1.05 to 1.2. Numerical results are presented and compared with the experimental data by other researchers. The simulated wavelengths of A0, A1, A2, and B modes and part of simulated amplitudes agree very well with the measurement data by Ponton and Seiner ["The effects of nozzle exit lip thickness on plume resonance," J. Sound Vib. 154, 531 (1992)]. In particular, the phenomena of modes jumping have been captured correctly although the numerical procedure has to be improved to predict the amplitudes of supersonic jet screech tones more accurately. Furthermore, the phenomena of shock motions are analyzed. The predicted splitting and combination of shock cells are similar with the experimental observations of Panda ["Shock oscillation in underexpanded screeching jets," J. Fluid. Mech. 363, 173 (1998)]. Finally, the receptivity process is numerically studied and analyzed. It is shown that the receptivity zone is associated with the initial thin shear layer, and the incoming and reflected sound waves.

  10. Effects of bronchomotor tone and gas density on time dependence of forced expiratory vital capacity maneuver. (United States)

    D'Angelo, E; Milic-Emili, J; Marazzini, L


    It has been shown that in normal subjects and chronic obstructive pulmonary disease (COPD) patients the maximal expiratory flows and FEV1 are significantly higher if the FVC maneuver is preceded by a rapid inspiration without an end-inspiratory pause (maneuver 1) compared with a slow inspiration with an end-inspiratory pause of approximately 5 s (maneuver 2). This time dependency of FVC was attributed primarily to loss of lung recoil (stress relaxation) during breath-holding at TLC, in association with time constant inequality within the lungs, and changes in bronchomotor tone. To examine the role of bronchomotor tone on time dependency of FVC, 11 COPD and 10 asthmatic patients performed FVC maneuvers 1 and 2 before and after administration of a bronchodilator drug (salbutamol). In addition, using the same approach, the effects of changing airway resistance per se were assessed in another group of 10 COPD patients and 10 normal subjects, while breathing air and after equilibration with 80% helium in oxygen. Main findings were: peak expiratory flow (PEF), FEV1, and maximal midexpiratory flow rate (MMF) were significantly larger with maneuver 1 than 2; after salbutamol administration and during helium-oxygen breathing, all indices increased significantly with both maneuvers but the relative differences between maneuvers 1 and 2 were unchanged. We conclude that time dependency of maximal expiratory flow-volume (MEFV) curves, as indexed by PEF, FEV1, and MMF, is largely independent of bronchomotor tone and gas density, and probably reflects mainly stress relaxation of the respiratory tissues. The relevance of time dependency of FVC maneuver in the assessment of bronchodilator response and density dependence is discussed.

  11. Endothelial GATA-6 Deficiency Promotes Pulmonary Arterial Hypertension (United States)

    Ghatnekar, Angela; Chrobak, Izabela; Reese, Charlie; Stawski, Lukasz; Seta, Francesca; Wirrig, Elaine; Paez-Cortez, Jesus; Markiewicz, Margaret; Asano, Yoshihide; Harley, Russell; Silver, Richard; Feghali-Bostwick, Carol; Trojanowska, Maria


    Pulmonary arterial hypertension (PAH) is a chronic and progressive disease characterized by pulmonary vasculopathy with elevation of pulmonary artery pressure, often culminating in right ventricular failure. GATA-6, a member of the GATA family of zinc-finger transcription factors, is highly expressed in quiescent vasculature and is frequently lost during vascular injury. We hypothesized that endothelial GATA-6 may play a critical role in the molecular mechanisms underlying endothelial cell (EC) dysfunction in PAH. Here we report that GATA-6 is markedly reduced in pulmonary ECs lining both occluded and nonoccluded vessels in patients with idiopathic and systemic sclerosis-associated PAH. GATA-6 transcripts are also rapidly decreased in rodent PAH models. Endothelial GATA-6 is a direct transcriptional regulator of genes controlling vascular tone [endothelin-1, endothelin-1 receptor type A, and endothelial nitric oxide synthase (eNOS)], pro-inflammatory genes, CX3CL1 (fractalkine), 5-lipoxygenease-activating protein, and markers of vascular remodeling, including PAI-1 and RhoB. Mice with the genetic deletion of GATA-6 in ECs (Gata6-KO) spontaneously develop elevated pulmonary artery pressure and increased vessel muscularization, and these features are further exacerbated in response to hypoxia. Furthermore, innate immune cells including macrophages (CD11b+/F4/80+), granulocytes (Ly6G+/CD45+), and dendritic cells (CD11b+/CD11c+) are significantly increased in normoxic Gata6-KO mice. Together, our findings suggest a critical role of endothelial GATA-6 deficiency in development and disease progression in PAH. PMID:23583651

  12. Eléments d'analyse du cliquetis et de ses effets Elements for Analyzing Knocking and Its Effects

    Directory of Open Access Journals (Sweden)

    Douaud A.


    Full Text Available On présente dans cet article une synthèse des travaux théoriques et expérimentaux relatifs à la génération du cliquetis et à ses effets sur le fonctionnement du moteur. L'apparition du cliquetis est décrite par un mécanisme global de délai d'auto-inflammation. Des exemples d'application portant sur l'identification du délai de carburants quelconques et sur l'optimisation de l'ensemble moteurs-carburants documentent cette approche. Le cliquetis a pour conséquence un accroissement de sollicitations mécaniques et thermiques des parois de la chambre de combustion. Des méthodes et résultats d'investigation de ces phénomènes sont présentés. A synthesis is presented of theoretical and experimental research concerning the generating of knocking and its effects on engine running. The appearance of knocking is described by an overall mechanism of autoignition delay. This approach is documented by applied examples concerning the identification of the delay involved with any type of fuel and the optimizing of engine-fuel systems. Knocking causes an increase in mechanical and thermal stresses on combustion-chamber walls. Investigational methods and results concerning these phenomena are described.

  13. Reference values for local arterial stiffness. Part B : femoral artery

    NARCIS (Netherlands)

    Bossuyt, Jelle; Engelen, Lian; Ferreira, Isabel; Stehouwer, Coen D; Boutouyrie, Pierre; Laurent, Stéphane; Segers, Patrick; Reesink, Koen; Van Bortel, Luc M


    OBJECTIVE: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (C

  14. Dual anterior descending coronary artery associated with coronary artery disease

    Directory of Open Access Journals (Sweden)

    Siqueira Luciane da L. V.


    Full Text Available The patient is a male with risk factors for coronary artery disease, who was referred for cardiac catheterization after acute myocardial infarction in the inferior wall. The patient underwent transluminal coronary angioplasty in the right coronary artery with successful stent implantation.

  15. Association between internal carotid artery dissection and arterial tortuosity

    Energy Technology Data Exchange (ETDEWEB)

    Saba, Luca; Piga, Mario [Azienda Ospedaliero Universitaria (A.O.U.), Department of Radiology, Monserrato, Cagliari (Italy); Argiolas, Giovanni Maria; Siotto, Paolo [Azienda Ospedaliero Brotzu (A.O.B.), Department of Radiology, di Cagliari (Italy); Sumer, Suna; Wintermark, Max [Neuroradiology Division, Neuroradiology, UVA Department of Radiology, Charlottesville, VA (United States); Raz, Eytan [New York University School of Medicine, Department of Radiology, New York, NY (United States); Sapienza University of Rome, Department of Neurology and Psychiatry, Rome (Italy); Sanfilippo, Roberto; Montisci, Roberto [Azienda Ospedaliero Universitaria (A.O.U.), Department of Vascular Surgery, di Cagliari (Italy)


    Carotid artery dissection is an important cause of ischemic stroke in all age groups, particularly in young patients. The purpose of this work was to assess whether there is an association between the presence of an internal carotid artery dissection (ICAD) and the arterial tortuosity. This study considered 124 patients (72 males and 52 females; median age 57 years) with CT/MR diagnosis of ICAD of the internal carotid artery were considered in this multi-centric retrospective study. The arterial tortuosity was evaluated and, when present, was categorized as elongation, kinking, or coiling. For each patient, both the right and left sides were considered for a total number of 248 arteries in order to have the same number of cases and controls. Fisher's exact test was applied to test the association between elongation, kinking, coiling, dissection, and the side affected by CAD. Fisher's exact test showed a statistically significant association between the ICAD and kinking (p = 0.0089) and coiling (p = 0.0251) whereas no statistically significant difference was found with arterial vessel elongation (p = 0.444). ICAD was more often seen on the left side compared to the right (p = 0.0001). These results were confirmed using both carotid arteries of the same patient as dependent parameter with p = 0.0012, 0.0129, and 0.3323 for kinking, coiling, and elongation, respectively. The presence of kinking and coiling is associated with ICAD. (orig.)

  16. Dialect and tone sandhi%方音与连续变调

    Institute of Scientific and Technical Information of China (English)



      In the field of second language acquisition, the dialect research focus on the effects of first language to the second language segment from the phonological acquisition. This research attempts to through acoustic instruments, from the perspective of migration to study suprasegmental level of tone sandhi and dialect experience of the relationship, in order to reveal the spoken"dialect"in essence. The experimental results show that, the migration effect does exist in continuous tone level, the tone sandhi system of Putian dialect would interfere with Mandarin sandhi output, resulting in bilinguals speak with accents. At the same time as the Mandarin experience increases, the Putian dialect tone system changes, thus proving the necessity of suprasegmental level reverse migration.%  在二语习得领域,对方音的研究,从语音习得层面的考察重点都集中在第一语言对第二语言音段层面的影响上。本研究试图通过声学手段,从迁移的角度考察超音段层面——连续变调与方言语音经验的关系,以揭示普通话口语中“方音”的本质。实验结果表明,迁移效应确实存在于连续变调层面,莆田方言的连续变调体系会干扰普通话连续变调的产出,导致双语者说话伴有口音。同时随着普通话经验的增加,莆田方言的变调体系发生变异,从而证明了超音段层面反向迁移的必然性。

  17. Interpreting tone of voice: musical pitch relationships convey agreement in dyadic conversation. (United States)

    Okada, Brooke M; Lachs, Lorin; Boone, Benjamin


    Previous research has found that the musical intervals found in speech are associated with various emotions. Intervals can be classified by their level of consonance or dissonance-how pleasant or unpleasant the combined tones sound to the ear. Exploratory investigations have indicated that in an agreeable conversation, the pitches of the last word in an utterance and the first word of a conversation partner's utterance are consonantly related; in a disagreeable conversation, the two pitches are dissonantly related. The present results showed that the intervals between the tonics of the utterances in a conversation corresponded to the agreement between interlocutors.

  18. Sound power emitted by a pure-tone source in a reverberation room

    DEFF Research Database (Denmark)

    Jacobsen, Finn; Molares, Alfonso Rodriguez


    Energy considerations are of enormous practical importance in acoustics. In "energy acoustics," sources of noise are described in terms of the sound power they emit, the underlying assumption being that this property is independent of the particular environment where the sources are placed. However......, it is well known that the sound power output of a source emitting a pure tone or a narrow band of noise actually varies significantly with its position in a reverberation room at low frequencies, and even larger variations occur between different rooms. The resulting substantial uncertainty in measurements...

  19. Simultaneous Measurement of Nonlinearity and Electrochemical Impedance for Protein Sensing Using Two-Tone Excitation (United States)

    Daniels, Jonathan S.; Anderson, Erik P.; Lee, Thomas H.; Pourmand, Nader


    Impedance biosensors detect the binding of a target to an immobilized probe by quantifying changes in the impedance of the electrode-electrolyte interface. The interface's I-V relationship is inherently nonlinear, varying with DC bias, and target binding can alter the degree of nonlinearity. We propose and demonstrate a method to simultaneously measure the nonlinearity and conventional small-signal impedance using intermodulation products from a two-tone input. Intermodulation amplitudes accurately reflect the impedance's manually-measured voltage dependence. We demonstrate that changes in nonlinearity can discriminate protein binding. Our measurements suggest that target binding can alter nonlinearity via the voltage dependence of the ionic double layer. PMID:19164024

  20. Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation. (United States)

    Singh, Jagmohan; Kumar, Sumit; Krishna, Chadalavada Vijay; Rattan, Satish


    Internal anal sphincter (IAS) tone plays an important role in rectoanal incontinence (RI). IAS tone may be compromised during aging, leading to RI in certain patients. We examined the influence of oxidative stress in the aging-associated decrease in IAS tone (AADI). Using adult (4-6 mo old) and aging (24-30 mo old) rats, we determined the effect of oxidative stress on IAS tone and the regulatory RhoA/ROCK signal transduction cascade. We determined the effect of the oxidative stress inducer LY83583, which produces superoxide anions (O2 (·-)), on basal and stimulated IAS tone before and after treatment of intact smooth muscle strips and smooth muscle cells with the O2 (·-) scavenger SOD. Our data showed that AADI was associated with a decrease in RhoA/ROCK expression at the transcriptional and translational levels. Oxidative stress with a LY83583-mediated decrease in IAS tone and relaxation of IAS smooth muscle cells was associated with a decrease in RhoA/ROCK signal transduction, which was reversible by SOD. In addition, LY83583 caused a significant decrease in IAS contraction produced by the RhoA activator and a known RhoA/ROCK agonist, U46619, that was also reversible by SOD. The inhibitory effects of LY83583 and the ROCK inhibitor Y27632 on the U46619-induced increase in IAS tone were similar. We conclude that an increase in oxidative stress plays an important role in AADI in the elderly and may be one of the underlying mechanisms of RI in certain aging patients.