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Sample records for arteria umbilical humana

  1. ¿Tanta importancia tiene pasar por alto la arteria umbilical única?: Comentarios a partir de una sentencia judicial

    Directory of Open Access Journals (Sweden)

    A. Ortega Pérez

    2004-07-01

    Full Text Available El Tribunal Supremo ha condenado a varios obstetras por informar que el cordón umbilical tenía los tres vasos, desactivando así la búsqueda de enfermedades fetales que la arteria umbilical única (AUU habría desencadenado. La condena será éticamente correcta si la AUU está realmente asociada a tales enfermedades. En la población general se detecta un caso de AUU en cada 320 fetos estudiados ecográficamente. En el 68 % de esas detecciones se tratará de un hallazgo aislado, pero aún así aumenta el riesgo de parto prematuro, de peso bajo y de mortalidad perinatal. Por otra parte, el 17 % de estos fetos tendrán, además de la arteria única, cromosomopatías y el 31 % malformaciones anatómicas. Concluyendo, la AUU es realmente un marcador cardinal de riesgo de trastornos fetales, que debe buscarse activamente durante el seguimiento ecográfico del embarazo.

  2. Estudio de los mecanismos contráctiles de la musculatura lisa vascular en arterias mesentéricas humanas y su modificación por el envejecimiento : papel del retículo sarcoplásmico

    OpenAIRE

    Navarro Dorado, Jorge

    2013-01-01

    Se ha realizado un estudio de los procesos contráctiles de la musculatura lisa vascular en arterias humanas, comprobando las posibles implicaciones del retículo sarcoplásmico en el proceso contráctil y las diferencias que pudieran existir debidas al envejecimiento. Para ello se han utilizado arterias mesentéricas humanas de pacientes de diferentes edades, realizando el estudio con cuatro técnicas distintas: miografía vascular, para la medición de los procesos contráctiles arteriales, microsco...

  3. ¿Tanta importancia tiene pasar por alto la arteria umbilical única?: Comentarios a partir de una sentencia judicial Does ignoring the single umbilical artery have so much importance?: Commentaries concerning a judicial sentence

    Directory of Open Access Journals (Sweden)

    A. Ortega Pérez

    2004-07-01

    Full Text Available El Tribunal Supremo ha condenado a varios obstetras por informar que el cordón umbilical tenía los tres vasos, desactivando así la búsqueda de enfermedades fetales que la arteria umbilical única (AUU habría desencadenado. La condena será éticamente correcta si la AUU está realmente asociada a tales enfermedades. En la población general se detecta un caso de AUU en cada 320 fetos estudiados ecográficamente. En el 68 % de esas detecciones se tratará de un hallazgo aislado, pero aún así aumenta el riesgo de parto prematuro, de peso bajo y de mortalidad perinatal. Por otra parte, el 17 % de estos fetos tendrán, además de la arteria única, cromosomopatías y el 31 % malformaciones anatómicas. Concluyendo, la AUU es realmente un marcador cardinal de riesgo de trastornos fetales, que debe buscarse activamente durante el seguimiento ecográfico del embarazo.The Spanish Supreme Court has condemned several obstetricians after having informed that the umbilical cord of a fetus had the three vessels, therefore deactivating the search for fetal diseases that the single umbilical artery (SUA would have provoked. The sentence will be ethically correct only if SUA is really associated with such diseases. SUA is found in about 1 out of every 320 fetuses studied sonographically. In 68% of them, it will be an isolated finding, although it will increase the risks of premature delivery, low birthweight, and perinatal mortality. On the other hand, 17% of these fetuses will have, besides SUA, chromosomal alterations, and 31 % of them, structural malformations. In conclusion, SUA is an important marker of fetal disorders, and it has to be actively searched for during the ultrasonographic monitoring of the gestation.

  4. Arteria sinuosa del colon: su importancia en la circulación colateral intestinal

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    Edgar Giovanni Corzo Gómez,

    2008-04-01

    Full Text Available La circulación colateral de la vascularización mesentéricaha sido bien descrita. La arteria Marginal o arteria deDrummond, se ubica paralela al borde mesentérico delintestino grueso, y el arco de Riolan, conecta la ramaizquierda de la arteria cólica media con la rama ascendentede la arteria cólica izquierda a través de una porción de laarteria Marginal. Recientemente Moskowitz y colabora-dores describieron la arteria mesentérica sinuosa, como unnuevo vaso colateral con grandes implicacionesquirúrgicas. El objetivo de este artículo es describir laimportancia clínica y quirúrgica de esta arteria.

  5. Musica Humana og musikterapi

    DEFF Research Database (Denmark)

    Schou, Karin

    2005-01-01

    I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres for defi......I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres...... for definitioner af relevante niveauer af musikterapi i denne sammenhæng; Musica Humanas formål; MusiCure’s tilblivelse; baggrunden for og relevansen af en musikterapeuts tilstedeværelse i Musica Humana, samt hvilken rolle musikterapeuten kan spille i denne sammenhæng. Medlemmer af Musica Humanas styregruppe...... bidrager med udsagn om deres opfattelse af relevansen af en musikterapeut som ressourceperson i Musica Humana....

  6. Trombosis de la arteria renal en un recién nacido. Presentación de un caso y revisión

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    Ana Lucía Torres

    2009-12-01

    Full Text Available Se describe un neonato que presenta cifras tensionales elevadas y ausencia de pulsos en miembros inferiores en su cuarto día de vida después de la colocación de un catéter umbilical arterial, evidenciando trombosis en arteria aorta y renal izquierda. Se realizó gammagrafía con MAG 3 que mostró exclusión renal izquierda y angioresonancia de aorta y renal izquierda. Se inició manejo con heparina no fraccionada y estreptoquinasa durante 6 horas. Se recuperó totalmente el compromiso en miembros inferiores, mejorando cifras tensionales a los pocos días. Estudios de seguimiento de función renal y crecimiento evidencian flujo de arteria renal izquierda y algo de función. Se describe mejoría con tratamiento anticoagulante y trombolítico de un riñón neonatal a pesar de sufrir isquemia prolongada.

  7. Vida humana y persona

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    Antonio Marlasca López

    2002-09-01

    Full Text Available En este ensayo, más que un juego lingüístico de términos y expresiones, se tratara de enfatizar los términos vida humana y persona humana, como estos de la simple sinonimia en la conversación habitual, han sido trastocados en sofisticado instrumento jurídico, al concluir en Costa Rica la Sala Constitucional, por quien sabe que ciencia infusa, que el embrión recién fecundado ya es persona. Por tanto se enfatiza con fuerza el contrasentido de aseverar que el principio y el producto son lo mismo, entendiendo que la semilla es diferente al fruto, citando a Savater, cuando dijo que el que come un huevo no ha comido pollo. El embrión recién fecundado o pre-embrión, es principio, semilla, potencia, quizás un día sea persona, de ahí la conclusión de que no toda vida humana es persona humana.In this essay, more than a linguistic game of terms and expressions, we treat the meanings of human life and the human person, and how this simooms in the habitual language, have been to changed into a sophisticated judicial tool, by the conclusion of the Costa Rican Constitutional Court, who using a mysterious science, has said that once the ovule has been fecund, it is a human being. For that reason we emphasize the contra sense to sever that the beginning is the same than the product, understanding that the seed is different than the fruit, referring to Savater, when he said, when you eat an egg you are not eat chicken. The embryo recently fecund or pre-embryo is beginning, seed, potency, maybe one day it will be a human person, from there the conclusion that not all human life is a human person.

  8. La agresividad humana

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    Olimpia López Avendaño

    2004-01-01

    Full Text Available En este artículo se comparan los planteamientos de Sigmund Freud, Herbert Marcusse y Erich Fromm en torno a la agresividad humana. Analizar esta temática en el contexto actual es relevante dado el incremento de acciones que conllevan gran dosis de violencia tanto en el plano físico, como en el psicológico y espiritual, así como la urgencia de plantear soluciones. La posición de los tres autores permite visualizar la pertinencia de explicaciones que tienden a asumirse en la vida cotidiana en torno a este fenómeno y, sobre todo, construir nuevas perspectivas que las relean, trasciendan y enriquezcan.

  9. PERSONA HUMANA Y PERSONALISMO

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    Elio Sgreccia

    2013-01-01

    Full Text Available En la primera parte del artículo se analiza la evolución histórico-filosófica del concepto de persona humana, desde la antigüedad hasta el pensamiento contemporáneo, enunciando las ideas más relevantes al respecto. En la segunda parte se realiza un análisis crítico de las posiciones reduccionistas o empiristas, en particular de las de Engelhardt y el utilitarismo, analizando algunas de sus consecuencias prácticas en bioética. El autor concluye enunciando lo que serían los principios fundamentales de la bioética personalista, su fundamentación ontológica, así como el posible desarrollo contemporáneo de la intuición inicial, enunciada por vez primera por Sgreccia en los ochenta.

  10. Capital humano y capacidad humana

    OpenAIRE

    Sen, Amartya Kumar

    2010-01-01

    En este articulo se examinan las relaciones y diferencias entre el concepto de 'capital humano' y el concepto de 'capacidad humana'. El concepto de capital humano es mas limitado puesto que solo concibe las cualidades humanas en su relación con el crecimiento económico mientras que el concepto de capacidades da énfasis a la expansión de libertad humana para vivir el tipo de vida que la gente considera valedera. Cuando se adopta esa visión mas amplia, el proceso de desarrollo no puede verse si...

  11. La agresividad humana

    Directory of Open Access Journals (Sweden)

    López Avendaño, Olimpia

    2004-12-01

    Full Text Available En este artículo se comparan los planteamientos de Sigmund Freud, Herbert Marcusse y Erich Fromm en torno a la agresividad humana. Analizar esta temática en el contexto actual es relevante dado el incremento de acciones que conllevan gran dosis de violencia tanto en el plano físico, como en el psicológico y espiritual, así como la urgencia de plantear soluciones. La posición de los tres autores permite visualizar la pertinencia de explicaciones que tienden a asumirse en la vida cotidiana en torno a este fenómeno y, sobre todo, construir nuevas perspectivas que las relean, trasciendan y enriquezcan. In this article the expositions regarding human aggressiveness by Sigmund Freud, Herbert Marcusse and Erich Fromm are compared. The relevance of this subject's analysis in the present context is due to the increase of actions that entail a great dose of violence in the physical, psychological and spiritual planes; and to the urgency of raising solutions. The three authors' position allows us to see how adequate are the explanations that tend to be assumed in everyday life; and above all allow us to build new perspectives that make a new interpretation of them, that extend and enrich them

  12. Enfermedad de Kawasaki y Aneurisma Sacular Gigante de la Arteria Descendente Anterior: reporte de un caso

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    Carlos Mas Romero

    2003-08-01

    Full Text Available La enfermedad de Kawasaki se caracteriza por una vasculitis generalizada, de singular gravedad cuando afecta las arterias coronarías, lo cual ocurre hasta en el 40 % de los casos no tratados. El tratamiento combinado de aspirina con gammaglobulina intravenosa precoz y a altas dosis ha conseguido disminuir la incidencia de la patología coronaría. A continuación se presenta el caso de una niña de 9 años de edad, con cuadro clínico de enfermedad de Kawasaki complicada con un aneurisma sacular gigante de la arteria coronaría izquierda. Los hallazgos ecocardiográficos y angiográficos se analizan y se revisa la literatura al respecto.

  13. Detection and treatment of an aneurysma spurium of the arteria hepatica dextra after laparoscopic cholecystectomy

    OpenAIRE

    Kirschberg, Oliver; Scheding, Andreas; Saers, Thomas; Krakamp, Bernd

    2013-01-01

    Background Massive upper gastrointestinal hemorrhage can be the dominant symptom of decompensated liver cirrhosis, varices and ulcerations in the upper gastrointestinal tract. Postoperative complications are known to lead to these bleedings. Commonly, emergency endoscopy will be performed. Here we report of a patient with extensive bleeding caused by an aneurysma spurium of the arteria hepatica dextra induced by a laparoscopic cholecystectomy. The condition was diagnosed by the Doppler ultras...

  14. Variante anatómica: origen de la arteria hepática derecha de la arteria mesentérica superior

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    David Rodríguez Palomo

    2011-03-01

    Full Text Available Este trabajo describe la presencia de la variante anatómica que presenta la arteria hepática derecha como rama de la arteria mesentérica superior en un caso incidental de disección en la Escuela de Medicina de la Universidad de Costa Rica, dicha variante se presenta desde un 6,4% hasta un 18% por lo que debe siempre tenerse en cuenta durante cualquier cirugía hepatobiliar y más aún si se trata de cirugía de trasplante hepático. Así mismo se revisa el tema y su importancia clínica.This paper describes the presence of anatomical variation has the right hepatic artery as a branch of the artery superior mesenteric artery a case incidental to the School of Medicine, University of Costa Rica, said variant is present from 6.4% to 18% and should be always be taken into account during any hepatobiliary surgery and more so if it is liver transplant surgery. It also reviews the issue and its clinical significance.

  15. Origen anómalo de la arteria coronaria izquierda originándose de la arteria pulmonar. Reporte de caso y revisión de literatura

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    José Jiménez Vega

    2007-01-01

    Full Text Available Se presenta el caso de un lactante de 2 meses de edad que consultó por tos y dificultad respiratoria; al ser admitido en el servicio de urgencias, el abordaje inicial fue de una infección respiratoria baja (bronquiolitis pero la evolución tórpida y la presencia de cardiomegalia hizo sospechar una cardiopatía, diagnosticándose origen anómalo de la arteria coronaria izquierda que nace de la arteria pulmonar, la cual fue tratada quirúrgicamente con resultado favorable.2 month old male who was brought to the emergency department with a history of non productive cold, was noticed with difficulty breathing. He was admitted with the possible diagnosis of bronquioloitis. The poor evolution of the patient, and the presence of cardiomegaly, made the physicians look for a cardiopathy, and a diagnosis of anomalous left coronary artery from the pulmonary artery was made. He was stabilized and then was taken to the operating room and had his anomalous coronary artery reimplanted to his aorta

  16. Anatomía de la arteria temporal superficial: importancia quirúrgica: estudio piloto en cadáveres

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    J.J. Pradel-Mora

    2015-03-01

    Full Text Available El conocimiento preciso de los patrones vasculares permite mejorar los resultados de la reconstrucción regional del pabellón auricular y el diseño de colgajos regionales dependientes de la arteria temporal superficial para la reconstrucción facial. En México, no contamos en la actualidad con descripciones anatómicas de las variantes vasculares normales de la arteria temporal superficial. El objetivo de este trabajo es la descripción de las variantes anatómicas de la arteria temporal superficial a través de la disección de este vaso en 12 regiones tempo-parieto-occipitales en cadáveres. Nuestros resultados muestran que la arteria temporal superficial siempre se divide en dos ramas, una anterior y otra posterior, la distribución de ésta se sitúa en el cuarto más posterior de la región temporal, con una bifurcación alta. La distribución de la anatomía vascular, tomando en cuenta el calibre mayor de la arteria temporal superficial con respecto a la arteria auricular posterior, la ausencia de esta última en 4 de las regiones estudiadas, así como la distancia de dichos vasos con respecto al conducto auditivo externo, sugieren que en nuestra población la irrigación del pabellón auricular depende de la arteria temporal superficial, restándole importancia a la aportación del riego sanguíneo de esta región por parte de la arteria auricular posterior. Nuestro estudio arroja resultados que indican la existencia de variaciones importantes en la anatomía vascular regional que justifican la realización de estudios posteriores que permitan una descripción mas detallada de la misma para aumentar el éxito de las intervenciones quirúrgicas.

  17. Umbilical Cable Recovery Load Analysis

    Institute of Scientific and Technical Information of China (English)

    YAN Shu-wang; JIA Zhao-lin; FENG Xiao-wei; LI Shi-tao

    2013-01-01

    Umbilical cable is a kind of integrated subsea cable widely used in the exploration and exploitation of oil and gas field.The severe ocean environment makes great challenges to umbilical maintenance and repair work.Damaged umbilical is usually recovered for the regular operation of the offshore production system.Analysis on cables in essence is a two-point boundary problem.The tension load at the mudline must be known first,and then the recovery load and recovery angle on the vessel can be solved by use of catenary equation.The recovery analysis also involves umbilicalsoil interaction and becomes more complicated.Calculation methods for recovery load of the exposed and buried umbilical are established and the relationship between the position of touch down point and the recovery load as well as the recovery angle and recovery load are analyzed.The analysis results provide a theoretical reference for offshore on-deck operation.

  18. Pseudo-aneurisma post-traumático de tronco de arteria coronaria izquierda

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    Melina M. Gallo

    2011-08-01

    Full Text Available El pseudo-aneurisma de arteria coronaria es extremadamente raro. Su historia natural es poco conocida y su tratamiento discutido. Se presenta el caso de un paciente con pseudo-aneurisma de tronco de la coronaria izquierda e infarto antero-apical del ventrículo izquierdo cinco años después de un paro cardíaco secundario a un traumatismo no penetrante de tórax. Se consideró entonces que la lesión no era pasible de corrección percutánea o quirúrgica por lo que se optó por tratamiento médico conservador. Una angiografía coronaria por tomografía computarizada multicorte realizada 10 años después del evento inicial mostró ausencia de progresión de la lesión.

  19. Diagnóstico y tratamiento de los aneurismas saculares de la arteria cerebral anterior

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    Raúl F. Matera

    1956-12-01

    Full Text Available Hacemos un estudio anátomo-funcional de la arteria cerebral anterior recalcando la importancia que tiene la ligadura de esta arteria. Sintetizamos la patogenia de los aneurismas en cuatro hechos fundamentales: los aneurismas vestigiales originados en brotes vasculares no desarrollados o que no han involucionado normalmente; la falta de desarrollo de la túnica elástica en la zona de bifurcación de los grandes vasos; la arterioesclerosis; los procesos inflamatorios de la túnica media (sífilis y micosis. Hacemos un estudio clínico de los aneurismas del complejo cerebral-comunicante anterior, llamando la atención sobre aquellos en los que, a las hemorragias subaracnoidales, se asocian manifestaciones en el fondo de ojo, trastornos psíquicos y fenómenos motores. Llamamos la atención sobre las formas pseudo-tumorales quiasmáticas y los denominados aneurismas trombosantes que originan el síndrome progresivo fronto-cíngulo-calloso. Estudiamos la radiología simple de los aneurismas de esta región, llamando la atención sobre las calcificaciones cirsoideas suprasellares y los fenómenos de erosión de la silla turca. Llamamos la atención sobre la importancia de la arteriografía para confirmar el diagnóstico, estudiar la circulación colateral, el tamaño, la forma y el pedículo del aneurisma, elementos fundamentales para el plan operatório. En el tratamiento quirúrgico descartamos, por ineficaz, la ligadura de la carótida interna en el cuello. Es fundamental el abordaje intracraneano por vía subfrontal en los aneurismas de la porción précomunicante y comunicante con desarrollo hacia abajo, mientras que, la via sagital-frontal se utilizará en los aneurismas de desarrollo hacia arriba ya sea de la comunicante o de la porción distal de la arteria cerebral anterior o sus ramas. Insistimos sobre un hecho muy importante cual es la anestesia y, en especial, el uso de la hipotensión controlada, insistiendo de que la tensión se

  20. DEPENDIENTES Y RACIONALES: LA FAMILIA HUMANA

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    Alfredo Marcos Martínez

    2012-01-01

    Full Text Available Son muchos los conceptos que condicionan la bioética, que pueden hacer que prospere o naufrague. Nos centramos aquí en dos de ellos, a saber, el concepto de dependencia, que funciona como necesario complemento del de autonomía, y el concepto de familia humana, que tal vez debería funcionar como sustituto en contextos morales del de especie humana. Ambos remiten en el fondo a otro concepto, de larga tradición filosófica, el de naturaleza humana, que ha vuelto al centro del debate en los últimos años. La modernidad puede ser caracterizada como una búsqueda de la autonomía. La autonomía en muchos sentidos es un objetivo justo y deseable. Sin embargo, el énfasis unilateral en la autonomía ha generado una antropología parcial. De ahí la importancia de pensar también una antropología de la dependencia que vincule a los miembros de la familia humana.

  1. Religious perspectives on umbilical cord blood banking.

    Science.gov (United States)

    Jordens, Christopher F C; O'Connor, Michelle A C; Kerridge, Ian H; Stewart, Cameron; Cameron, Andrew; Keown, Damien; Lawrence, Rabbi Jeremy; McGarrity, Andrew; Sachedina, Abdulaziz; Tobin, Bernadette

    2012-03-01

    Umbilical cord blood is a valuable source of haematopoietic stem cells. There is little information about whether religious affiliations have any bearing on attitudes to and decisions about its collection, donation and storage. The authors provided information about umbilical cord blood banking to expert commentators from six major world religions (Catholicism, Anglicanism, Islam, Judaism, Hinduism and Buddhism) and asked them to address a specific set of questions in a commentary. The commentaries suggest there is considerable support for umbilical cord blood banking in these religions. Four commentaries provide moral grounds for favouring public donation over private storage. None attach any particular religious significance to the umbilical cord or to the blood within it, nor place restrictions on the ethnicity or religion of donors and recipients. Views on ownership of umbilical cord blood vary. The authors offer a series of general points for those who seek a better understanding of religious perspectives on umbilical cord blood banking. PMID:22558902

  2. GESTIÓN HUMANA: TENDENCIAS Y PERSPECTIVAS

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    JUAN GUILLERMO SALDARRIAGA RÍOS

    2008-01-01

    Full Text Available En este artículo se hace referencia a las tendencias y las perspectivas de gestión humana que se imponen en el mundo en la actualidad y que, a su manera, pretenden optimizar la administración del personal de la organización y contribuir al desarrollo e incremento de la productividad y la competitividad. Mediante la realización de un Estado del Arte se logran determinar algunas de las tendencias más relevantes en la actualidad y se concluye que, cada vez con mayor fuerza, dichas tendencias se sustentan en discursos que pretenden "rescatar" al ser humano dentro de la organización, lo que no necesariamente se traduce en los procesos de gestión humana que se realizan en las organizaciones nacionales e internacionales.

  3. Myiasis gastrointestinal humana por Eristalis tenax

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    Kun Marcelo

    1998-01-01

    Full Text Available Son caracterizadas las myiasis registradas en Bariloche y establecidas las condiciones probables bajo las cuales se produjeron las infestaciones. Las larvas obtenidas a partir de heces de 2 pacientes fueron identificadas como Eristalis tenax (Diptera: Syrphidae de acuerdo a las claves de Hartley (1961 y Organización Panamericana de la Salud (1962. Estos 2 casos de myiasis gastrointestinal humana constituyen los primeros registrados en Bariloche (Patagonia, Argentina y sus características responden a las registradas para esta especie de Díptera en otras partes del mundo. La falta de control específico en el sistema domiciliario de suministro de agua ha sido la causa más probable de la infestación. Este registro extiende la distribución de E. tenax y de las myiasis gastrointestinales humanas en América del Sur hasta los 41º 03' S.

  4. Ehrliquiosis granulocitotrópica humana

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    José Rafael Rojas-Solano

    2007-04-01

    Full Text Available Las ehrliquiosis humanas son zoonosis emergentes transmitidas por varias especies de garrapatas e infectan gran cantidad de animales silvestres y domésticos. Reportamos el caso de un paciente con un cuadro clínico y hallazgos de laboratorio compatibles con una probable ehrliquiosis granulocitotrópica severa. El paciente se trató con doxicilina y respondió adecuadamente. Fue egresado en buena condición.

  5. Endovascular Management of the Arteria Profunda Femoralis: Long-Term Angiographic and Clinical Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Karnabatidis, Dimitrios, E-mail: karnaby@med.upatras.gr; Spiliopoulos, Stavros; Pastromas, Georgios; Katsanos, Kostantinos; Siablis, Dimitrios [Patras University Hospital, School of Medicine, Department of Diagnostic and Interventional Radiology (Greece)

    2012-10-15

    Purpose: This study was designed to investigate the long-term angiographic and clinical outcomes of percutaneous transluminal angioplasty (PTA) of the arteria profunda femoralis (PFA), in a series of patients suffering from critical limb ischemia (CLI) or severe intermittent claudication (IC). Methods: Our department's database was searched to identify patients who underwent PTA or bail-out stenting of the PFA. Among the study's inclusion criteria were Rutherford categories 3-6 and {>=}70% stenosis of the PFA. Only de novo stenotic lesions were assessed. Primary endpoints were technical success, angiographic lesion primary patency, angiographic binary in-lesion restenosis, and target lesion recanalization (TLR) rates. Secondary endpoints included patient survival, limb salvage, and complication rates. Patient's baseline demographics, lesion, and procedural details were analyzed. Results: Between 2001 and 2011, 20 consecutive patients (17 males) with a mean age of 73 {+-} 9 (range 53-87) years underwent PTA or bail-out stenting in 23 PFA lesions. Critical limb ischemia was the indication in eight of 20 patients (40%). The mean lesion length was 31 {+-} 9.5 mm. The procedural technical success was 100% (23/23), whereas mean time angiographic and clinical follow-up was 26.8 {+-} 24.6 months. According to the Kaplan-Meier analysis, primary patency and binary restenosis rate were 95 and 86.1% respectively up to 8 years follow-up. No TLR procedures were performed. The 8-year patient survival and limb salvage rates were 87.5 and 84.7% respectively. Conclusions: PTA or stenting of focal, stenotic, PFA lesions, in patients suffering from CLI or IC, exhibit high long-term primary patency rates, as well as low binary restenosis and TLR rates. Large, multicenter studies are required to validate these results.

  6. Endovascular treatment of splenic artery aneurysms; Trattamento endovascolare degli aneurismi dell'arteria splenica

    Energy Technology Data Exchange (ETDEWEB)

    Lagana, Domenico; Carrafiello, Gianpaolo; Mangini, Monica; Fontana, Federico; Dizonno, Massimiliano; Fugazzola, Carlo [Insubria Univ., Varese (Italy). Cattedra di radiologia; Castelli, Patrizio [Insubria Univ., Varese (Italy). Chirurgia vascolare

    2005-07-15

    techniques, endovascular treatment is feasible in nearly all SAAs. It ensures good immediate and long term results, and no doubt presents some advantages in comparison to surgical treatment, as it less invasive and allows the preservation of splenic function. [Italian] Scopo. Verificare l'efficacia del trattamento endovascolare degli aneurismi dell'arteria splenica (AAS). Materiale e metodi. Nel periodo compreso tra maggio 2000 e giugno 2003 sono stati trattati 11 AAS veri in 9 pazienti (7 femmine e 2 maschi; eta media 58 anni), 8 sacciformi e 3 fusiformi, 4 localizzati al tratto medio, 5 al tratto distale e 2 intrasplenici. La diagnosi e stata effettuata con eco color Doppler e/o angio-TC ed e risultata occasionate in 7 pazienti e conseguente a dolore in ipocondrio sinistro in 1 caso; un AAS e stato riscontrato in fase di fissurazione. Quattro AAS sono stati esclusi mediante embolizzazione della sacca con microspirali, con preservazione della continuita dell'asse vascolare; in 2 casi e stata associata l'iniezione transcatetere di cianoacrilato. In 4 casi e stata effettuata una legatura endovascolare, con ischemia settoriaie della milza. Un AAS fisstirato e stato trattato in urgenza con embolizzazione massiva mediante cianoacrilato dell'arteria splenica. I 2 aneurismi intrasplenici sono stati esclusi, l'uno mediante embolizzazione dell'arteria afferente con cianoacrilato e l'altro con iniezione transcatetere di trombina nella sacca aneurismatica. Risultati. E stata ottenuta la devascolarizzazione completa di tutti gli AAS (in 10/11 al termine della procedura; in 1/11 al controllo TC, effettuato dopo 3 giorni). Il follow-up (durata media 18 mesi; range 6-36 mesi) e stato espletato con eco color Doppler e/o angio-TC a 3, 6, 12 mesi e successivamente una volta all'anno; la completa esclusione degli aneurismi e stata confermata in 11/11 casi. Le complicanze riscontrate sono state: 4 casi di pleurite sinistra di modesta entita; febbre

  7. Punciones repetidas de la arteria radial para cateterismo cardíaco Repeated radial artery puncture for cardiac catheterization

    Directory of Open Access Journals (Sweden)

    Eduardo Magariños

    2007-06-01

    Full Text Available La punción percutánea de la arteria radial para la realización de procedimientos por cateterismo ha ganado aceptación debido a una eficacia similar a la obtenida con el acceso femoral. En el presente trabajo evaluamos los resultados obtenidos con la punción repetida de esta arteria. En un total de 182 accesos radiales se realizaron 17 punciones repetidas, y mediante ellas, 20 procedimientos (9 coronariografías y 11 angioplastias. Se obtuvo éxito del acceso en 15 punciones repetidas (88.2% y éxito del procedimiento en todos los casos cuando logramos éxito del acceso. Si bien el grupo es pequeño es suficiente para mostrar que la punción repetida de la arteria radial es factible y permite una alta tasa de éxito de los procedimientos con una disminución ostensible de las complicaciones locales.The radial artery approach for percutaneous cardiac interventions has gained worldwide acceptance due to the similar results obtained by the femoral artery access. In this paper, we report our experience with repeated puncture of the radial artery. One hundred and eighty two radial artery access procedures were performed, in 17 interventions the puncture was repeated once or twice, with a total of 20 therapeutic catheterizations (9 coronary angiographies, 11 angioplasties. There was no therapeutic failure through the radial approach but, we successfully gained access in 88.2% (15/17 of the re-interventions cases. Although an experience with a low number of cases, we had a very high successful therapeutic rate, and also a remarkable lowering of local complications, this shows the feasibility and potential of this technique.

  8. Dissektion der Arteria carotis als Ursache ischämischer zerebrovaskulärer Ereignisse - Fallberichte und Diskussion

    Directory of Open Access Journals (Sweden)

    Tentschert S

    2003-01-01

    Full Text Available Dissektionen der kraniozervikalen Gefäße, inbesondere der Arteria carotis, zählen zu den häufigsten Ursachen ischämischer zerebrovaskulärer Ereignisse bei jüngeren Patienten. Die ischämische Symptomatik wird durch eine Wühlblutung in die Gefäßwand verursacht, welche entweder zu einer Minderung des zerebralen Blutflusses und/oder zu einer lokalen Thrombosierung mit nachfolgender Embolisation führt. Karotisdissektionen können durch ein mechanisches Trauma hervorgerufen werden, sie entstehen aber auch spontan oder sind dann bei einem Teil der Patienten mit Bindegewebserkrankungen assoziiert. Zu den häufigsten Symptomen zählen Kopfschmerzen, zervikaler Schmerz und Horner-Syndrom. Die zerebrale Ischämie führt meist zu einer transienten ischämischen Attacke (TIA oder zu einem ischämischen Infarkt im Stromgebiet der Arteria cerebri media der betroffenen Seite. Auch eine Amaurosis fugax kann auftreten. Trotz neuer technischer Möglichkeiten stellen Dissektionen der hirnversorgenden Gefäße nach wie vor eine diagnostische Herausforderung dar. Die digitale Subtraktionsangiographie gilt derzeit noch als Goldstandard zur Diagnostik, wird aber in vielen Fällen zunehmend durch neue nichtinvasive bildgebende Verfahren ersetzt oder ergänzt. Stenose oder Verschluß des betroffenen Gefäßes bilden sich in den meisten Fällen innerhalb von zwei Monaten nach dem Ereignis zurück. Therapeutische Maßnahmen haben vor allem die Verhinderung embolischer Komplikationen zum Ziel. Die gegenständliche Arbeit soll anhand von Fallbeispielen und einer Literaturübersicht klinisch relevante Aspekte und Probleme bei Diagnostik und Therapie der Dissektion der Arteria carotis aufzeigen.

  9. Tratamiento de la compresión del tronco de la arteria coronaria izquierda en pacientes con hipertensión pulmonar

    Directory of Open Access Journals (Sweden)

    María L. Talavera

    2011-10-01

    Full Text Available La angina de pecho es un síntoma frecuente en pacientes con hipertensión pulmonar (HP de cualquier etiología. Aunque su fisiopatología no está aclarada, las causas propuestas son: la isquemia subendocárdica por aumento del estrés parietal del ventrículo derecho, la dilatación de la arteria pulmonar por incrementos transitorios de la presión pulmonar y la compresión extrínseca del tronco de la arteria coronaria izquierda (TCI por la arteria pulmonar (AP dilatada. Se presentan tres casos que muestran la relación entre la angina de pecho y la compresión del TCI en pacientes con HP asociada a cardiopatías congénitas, tratados mediante implante de stent coronario.

  10. Factor de crecimiento vascular endotelial total y Doppler de las arterias uterinas en preeclampticas y embarazadas normotensas sanas

    OpenAIRE

    Eduardo Reyna-Villasmil; Jorly Mejia-Montilla; Joel Santos-Bolívar; Duly Torres-Cepeda; Yolimar Navarro-Briceño; Nadia Reyna-Villasmil; Ismael Suarez-Torres

    2014-01-01

    El objetivo de la investigación fue establecer las concentraciones de factor de crecimiento vascular endotelial (VEGF) total en preeclámpticas y embarazadas normotensas, y relacionar los valores de los hallazgos Doppler de las arterias uterinas con las concentraciones plasmáticas. Se seleccionaron 160 sujetos. Se incluyeron 47 preeclámpticas severas (grupo A), 33 preeclámpticas leves (grupo B) y un grupo control con edades similares a los grupos de estudio de 80 embarazadas sanas (grupo C). L...

  11. Parálisis del plexo braquial por pseudoaneurisma de la arteria axilar tras luxación de hombro

    OpenAIRE

    Escuder Capafons, M.C.; Monllau García, Juan Carlos; Ballester Soleda, Jorge

    1997-01-01

    Las lesiones del plexo braquial y de las arterias subclavia y axilar son complicaciones poco frecuentes, pero importantes, de los traumatismos dé la cintura escapular. Las lesiones neurovasculares son más frecuentes en heridas penetrantes, pero son raras en traumatismos cerrados. Cuando la sintomatología neurológica se desarrolla insidiosamente, días o semanas después del traumatismo, hay que pensar en una lesión vascular. Presentamos un caso de parálisis del plexo braquial tar...

  12. Colgajo de perforantes de la arteria colateral cubital inferior para defectos por quemadura eléctrica en fosa cubital

    Directory of Open Access Journals (Sweden)

    I. González-Alaña

    2014-09-01

    Full Text Available Las quemaduras eléctricas producen lesiones profundas, especialmente las debidas a la entrada y salida de la corriente y al arco voltaico, que pueden dejar expuestas estructuras nobles y afectar áreas de flexo-extensión, como la fosa antecubital. Los defectos resultantes pueden cubrirse mediante colgajos libres o pediculados de brazo y antebrazo. Entre las distintas opciones quirúrgicas, el colgajo medial del brazo evita la interrupción de los ejes vasculares mayores y la secuela en la zona donante es discreta. Sin embargo, su uso está poco extendido por considerarse un colgajo de difícil disección debido a la variabilidad anatómica de las arterias colaterales cubitales superior e inferior que lo irrigan. Presentamos la cobertura para un defecto secundario a quemadura eléctrica en la fosa antecubital mediante un colgajo medial del brazo basado en las ramas perforantes de la arteria colateral cubital inferior. Aunque confirmamos en este caso la variabilidad vascular, la disección resultó sencilla y el resultado estético y funcional fue excelente.

  13. Hidatidosis humana en el Perú

    OpenAIRE

    Luis Guerra Montero; María Ramírez Breña

    2015-01-01

    El objetivo de este trabajo ha sido conocer el estado de la hidatidosis humana, por la gran incidencia que presenta en nuestro país, principalmente en la región central andina. La recopilación de datos fue a partir de la revisión de fuentes primarias sobre epidemiología, el ciclo vital del parásito y del manejo del paciente afecto de Hidatidosis. Algunos hallazgos permiten afirmar que la hidatidosis es una enfermedad producida por el estado larval del cestodo Echinococcus del género Granulosu...

  14. Metodologias multidimensionais em Ciências Humanas

    Directory of Open Access Journals (Sweden)

    Ruby Esther León Díaz

    2014-03-01

    Full Text Available Los cuestionamientos contemporáneos hechos a las ciencias humanas tienen como punto de partida la excesiva división disciplinar, aunada a la construcción de visiones deterministas y absolutas de la naturaleza, del ser humano, del espíritu, de las cosas, de las teorías y de los valores. El trabajo presentado por las docentes de la Pontificia Universidad Católica de São Paulo (PUC-SP apuntala sobre esos cuestionamientos desde la teoría de la complejidad del pensador judeo-francés Edgar Morin.

  15. Ehrliquiosis granulocitotrópica humana

    OpenAIRE

    José Rafael Rojas-Solano; Juan Villalobos-Vindas

    2007-01-01

    Las ehrliquiosis humanas son zoonosis emergentes transmitidas por varias especies de garrapatas e infectan gran cantidad de animales silvestres y domésticos. Reportamos el caso de un paciente con un cuadro clínico y hallazgos de laboratorio compatibles con una probable ehrliquiosis granulocitotrópica severa. El paciente se trató con doxicilina y respondió adecuadamente. Fue egresado en buena condición.Human ehrlichiosis are emergent tick-borne zoonoses, affecting many wild and domestic mammal...

  16. GESTIÓN HUMANA: TENDENCIAS Y PERSPECTIVAS

    OpenAIRE

    JUAN GUILLERMO SALDARRIAGA RÍOS

    2008-01-01

    En este artículo se hace referencia a las tendencias y las perspectivas de gestión humana que se imponen en el mundo en la actualidad y que, a su manera, pretenden optimizar la administración del personal de la organización y contribuir al desarrollo e incremento de la productividad y la competitividad. Mediante la realización de un Estado del Arte se logran determinar algunas de las tendencias más relevantes en la actualidad y se concluye que, cada vez con mayor fuerza, dichas tendencias se ...

  17. Concomitant sublay mesh repair of umbilical hernia and abdominoplasty

    OpenAIRE

    McKnight, Catherine L; Fowler, James L; Cobb, William S; Smith, Dane E; Carbonell, Alfredo M

    2012-01-01

    Concomitant mesh repair of large umbilical hernias and abdominoplasty pose a serious risk of devascularizing the umbilical stalk. A technique of placing mesh in a sublay manner, deep to the fascial defect, for an umbilical herniorrhaphy to avoid damage to the deep umbilical perforators during an abdominoplasty is described.

  18. Dirofilariose pulmonar humana: relato de sete casos

    Directory of Open Access Journals (Sweden)

    CAVALLAZZI RODRIGO SILVA

    2002-01-01

    Full Text Available Dirofilariose pulmonar humana é uma doença rara causada pelo parasita Dirofilaria immitis. Apresenta-se usualmente como um nódulo pulmonar solitário que mimetiza câncer de pulmão. Embora considerada uma doença clinicamente benigna, uma biópsia pulmonar excisional é quase sempre necessária para o diagnóstico. Relatam-se as características epidemiológicas, clínicas e radiológicas de sete casos de dirofilariose pulmonar humana em Florianópolis. De sete pacientes relatados, seis tiveram como achado radiológico um nódulo pulmonar e foram submetidos à biópsia pulmonar excisional para o diagnóstico. Em um paciente, a imagem radiológica não estava disponível para revisão e, portanto, não foi descrita no trabalho; o diagnóstico foi estabelecido pela biópsia transbrônquica.

  19. Umbilical scarring in hatchling American alligators

    Science.gov (United States)

    Wiebe, J.J.; Sepulveda, M.S.; Buckland, J.E.; Anderson, S.R.; Gross, T.S.

    2004-01-01

    Umbilical scarring is the presence of excess scar tissue deposited between abdominal dermal layers at the site of yolk sac absorption in hatchling American alligators (Alligator mississippiensis). The presence of this dermal condition plays a key evaluatory role in the overall quality and subsequent value for various commercial leather products. Despite the prevalent nature of this condition, currently the industry has no standardized protocols for its quantification. The objectives of this study were to examine the relationship between hatchling weight and age and incidence of umbilical scarring and to develop a quantifiable and reproducible technique to measure this dermal condition in hatchling American alligators. Thirty eggs from each of nine clutches were incubated in two separate incubators at different facilities and hatchling umbilical scarring was measured at 2 and 10 days of age using digital calipers. Umbilical area was calculated by multiplying umbilical length times umbilical width. There was a significant effect of both age and clutch on umbilical area (overall decline of 64%) by 10 days post-hatch. However, only five of the nine clutches utilized expressed a noticeable decline in the size of this dermal condition (range 67-74%). We had hypothesized that larger hatchlings would have larger umbilical areas and a slower rate of improvement in this condition during the first few days post-hatch. The differences in umbilical area and percent decline with age across clutches, however, were not associated with differences in initial hatchling weights. Within clutches and time periods, hatchling weight had no significant effect on the size and/or rate of decline of this condition. ?? 2004 Published by Elsevier B.V.

  20. Arco aórtico derecho, divertículo de Kommerell y arteria subclavia izquierda aberrante Right aortic arch, Kommerell's diverticulum and aberrant left subclavian artery

    Directory of Open Access Journals (Sweden)

    I. Simón-Yarza

    2011-08-01

    Full Text Available La arteria subclavia derecha aberrante o «arteria lusoria» es la variante anatómica más común del desarrollo embrionario de la aorta y sus ramas, llegando a estar presente en un 0,5-2% de la población; con menos frecuencia se puede encontrar una arteria subclavia izquierda aberrante asociada al arco aórtico derecho. Estas variantes anatómicas deben incluirse en el diagnóstico diferencial del ensanchamiento mediastínico superior visible en la radiografía de tórax. Se presenta el caso clínico de un paciente que presentaba arco aórtico derecho y arteria subclavia izquierda aberrante con dilatación en su origen (divertículo de Kommerell como causa de ensanchamiento mediastínico superior de etiología incierta detectado de manera incidental en una radiografía de tórax realizada en un paciente con sintomatología respiratoria.The right aberrant subclavian artery or «arteria lusoria» is the most common anatomical variant of the embryonic development of the aorta and its branches, with a presence in 0.5-2% of the population. Less frequently, a right aortic arch with aberrant left subclavian artery may be present. These anatomical variations should be included in the differential diagnosis of superior mediastinal widening seen on chest radiographs. In this report, we present a right aortic arch with left aberrant subclavian artery dilated at its origin (Kommerell's diverticulum as a cause of superior mediastinal widening detected incidentally on a chest radiograph.

  1. Aortic aneurysm secondary to umbilical artery catheterization

    International Nuclear Information System (INIS)

    A 14-month-girl presented with an asymptomatic posterior mediastinal mass. She had a history of prematurity, umbilical artery catheterization, and sepsis. The diagnosis of aortic aneurysm was made by dynamic computed tomography. The aneurysm was successfully resected. (orig.)

  2. Antenatal umbilical cord parameters and perinatal outcome

    Directory of Open Access Journals (Sweden)

    Athira Narayanan

    2016-04-01

    Conclusions: No association between antenatal umbilical cord characteristics and perinatal outcome was found in pregnancies at high risk for poor perinatal outcome. [Int J Reprod Contracept Obstet Gynecol 2016; 5(4.000: 1211-1215

  3. Umbilical Cord Segmental Hemorrhage and Fetal Distress

    OpenAIRE

    Larciprete, Giovanni; Romanini, Maria Elisabetta; Arduini, Domenico; Cirese, Elio; Slowikowska-Hilczer, Jolanta; Kula, Krzysztof

    2006-01-01

    We describe an unexplained case of umbilical cord segmental hemorrhage linked with meconium-stained amniotic fluid. A severely asphyxiated infant was delivered at term by Caesarean section. There were poor prognostic signs on fetal cardiotocography with rupture of membranes with meconium-stained amniotic fluid. The pathophysiologic mechanism in this case is still unknown, even if we argued a possible role of the umbilical cord shortness.

  4. Ehrliquiosis granulocitotrópica humana

    Directory of Open Access Journals (Sweden)

    José Rafael Rojas-Solano

    2007-04-01

    Full Text Available Las ehrliquiosis humanas son zoonosis emergentes transmitidas por varias especies de garrapatas e infectan gran cantidad de animales silvestres y domésticos. Reportamos el caso de un paciente con un cuadro clínico y hallazgos de laboratorio compatibles con una probable ehrliquiosis granulocitotrópica severa. El paciente se trató con doxicilina y respondió adecuadamente. Fue egresado en buena condición.Human ehrlichiosis are emergent tick-borne zoonoses, affecting many wild and domestic mammals. We report the case of a patient with a clinical picture and laboratory findings compatible with severe granulocytic ehrlichiosis. The patient was treated with doxyciclin and did fine.

  5. Epidemiologia da raiva humana na Guanabara

    Directory of Open Access Journals (Sweden)

    Alfredo R. Matta B. da Silva

    1971-08-01

    Full Text Available A raiva humana se mantém como problema de Saúde Pública, especialmente nas áreas urbanas, onde o cão atua como principal reservatório e fonte imediata de infecção. A deficiência de programas de controle de cães vadios, de imunização sistemática e de educação sanitária, contribui para a perpetuação da cadeia epidemiológioa. O presente estudo analisa todos os casos de raiva humana, observados em habitantes do Estado da Guanabara, no período 1965-1969, segundo as variáveis: idade, sexo, côr, variação estacional, período de incubação e de duração da fase clínica, fonte de infecção, local de mordedura e uso de vacina posterior à exposição. Os principais resultados foram: 1. A ravia na Guanabara, parece ser mais comum nos grupos etários mais jovens e nos homens. 2. Não se observou variação estacional. 3. O período de incubação mediano foi de 45 dias e de duração da fase clínica de 3 dias. 4. Ocorreu uma associação entre período de incubação menor e vacinação incompleta.

  6. Libertad humana y presciencia divina en Boecio

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    Manuel Correia M.

    2002-01-01

    Full Text Available En este artículo, me propongo mostrar que la discusión de Boecio sobre la compatibilidad de la libertad humana y la praescientia divina (De consolatione philosophiae, Libro V es una elaborada doctrina que une elementos neoplatónicos y lógica aristotélica. Según argumento, la discusión está conectada a la preocupación anterior sobre este tema mantenida por los estoicos, y sus principales líneas de desarrollo van a influir en pensadores como Santo Tomás de Aquino, L. Valla y G.W. Leibniz. En lo esencial, la doctrina de Boecio dice que no es la sola razón humana lo que hace al hombre libre, sino su fin, que es Dios como ser eternamente presente a los procesos necesarios y contingentes del universo. Esto está supuesto en sus palabras finales sobre el poder de la oraciónIn this article, I attempt to show that Boethius' discussion on the compatibility between human freedom and praescientia divina (De consolatione philosophiae, Book V is a refined piece of doctrine combining Neoplatonic elements and Aristotelian logic. The discussion, I argue, is connected to the Stoic early concern on the topic and its main lines of development are to be influential in later thinkers as St. Th. Aquinas, L. Valla and G.W. Leibniz. Basically, Boethius' doctrine means that it is not only the human reason by itself what makes the man free, but also the end of reason, i.e., God, who is eternally present to necessary and contingent processes in the universe. This is suggested by his final words on the power of prayer

  7. Umbilical Hernia Repair: Analysis After 934 Procedures.

    Science.gov (United States)

    Porrero, José L; Cano-Valderrama, Oscar; Marcos, Alberto; Bonachia, Oscar; Ramos, Beatriz; Alcaide, Benito; Villar, Sol; Sánchez-Cabezudo, Carlos; Quirós, Esther; Alonso, María T; Castillo, María J

    2015-09-01

    There is a lack of consensus about the surgical management of umbilical hernias. The aim of this study is to analyze the medium-term results of 934 umbilical hernia repairs. In this study, 934 patients with an umbilical hernia underwent surgery between 2004 and 2010, 599 (64.1%) of which were evaluated at least one year after the surgery. Complications, recurrence, and the reoperation rate were analyzed. Complications were observed in 5.7 per cent of the patients. With a mean follow-up time of 35.5 months, recurrence and reoperation rates were 3.8 per cent and 4.7 per cent, respectively. A higher percentage of female patients (60.9 % vs 29 %, P = 0.001) and a longer follow-up time (47.4 vs 35 months, P = 0.037) were observed in patients who developed a recurrence. No significant differences were observed between complications and the reoperation rate in patients who underwent Ventralex(®) preperitoneal mesh reinforcement and suture repair; however, a trend toward a higher recurrence rate was observed in patients with suture repair (6.5 % vs 3.2 %, P = 0.082). Suture repair had lower recurrence and reoperation rates in patients with umbilical hernias less than 1 cm. Suture repair is an appropriate procedure for small umbilical hernias; however, for larger umbilical hernias, mesh reinforcement should be considered.

  8. Bancos de cordón umbilical Umbilical cord banks

    Directory of Open Access Journals (Sweden)

    L. Madero

    2009-01-01

    Full Text Available La utilización de sangre de cordón como fuente de precursores hematológicos se remonta a 1983 cuando Boyse apuntó el potencial en progenitores existente en la sangre de cordón, realizándose un año más tarde las primeras experiencias sobre modelos murinos. Tuvieron que pasar más de cinco años para que Gluckman realizara la primera experiencia en humanos. Un niño afecto de anemia de Fanconi fue trasplantado con progenitores de sangre de cordón umbilical de su hermana HLA idéntica, realizándose todos los estudios de compatibilidad intraútero. Actualmente, veinte años más tarde, el paciente se encuentra libre de enfermedad y con la hematopoyesis del donante, demostrándose así la capacidad de persistencia del injerto a largo plazo.

  9. Evolution of umbilicals in Brazil: optimizing deepwater umbilical applications with thermoplastic hoses and steel tubes

    Energy Technology Data Exchange (ETDEWEB)

    Guerra Neto, Mauro Del [DuPont do Brasil S.A., Barueri, SP (Brazil)

    2008-07-01

    Subsea umbilicals in the past 25 years have evolved in parallel with other subsea oil and gas technologies, as the search for hydrocarbons needed to drive the global economy has led offshore exploration and development companies to seek reserves ever-farther from shore in water thousands of meters deep. Relegated to little more than afterthought status before the push into deep water, modern umbilicals have now become crucial components linking deep water producers to their subsea wells, controlling subsea production systems through hydraulic and electrical power and injecting production chemicals for corrosion-, scale-, and hydrate-inhibition at subsea well heads. Particularly in subsea developments involving several deep water wells, umbilicals today are integral to both the production-system design and the chosen operating strategy. Failure of an umbilical linking a subsea well head in deep water to a host production facility can inflict severe economic consequences upon an operator by impairing production operations or halting production altogether. The additional cost of repairing or replacing a failed umbilical can run into the millions of dollars. As offshore oil and gas production has moved into ever-deeper water, umbilical manufacturers have begun introducing new stronger materials to handle the inherently higher pressures and temperatures. Today, two types of construction are used for fluid conduits in umbilical systems deployed in deep water: thermoplastic hoses and steel tubes. Steel tubes are generally more expensive than thermoplastic hoses, relatively stiff and considered to have high tensile strength, while thermoplastic hoses are extremely flexible and exhibit lower tensile strength. This lower tensile strength of the hoses may be compensated by including steel wire armoring in the umbilical. This also provides the added benefits of additional mechanical protection compared with the equivalent unarmored steel-tubes umbilicals. When either

  10. Capital humano y capacidad humana Human capital and human capacity

    OpenAIRE

    Sen Amartya Kumar

    1998-01-01

    En este articulo se examinan las relaciones y diferencias entre el concepto de 'capital humano' y el concepto de 'capacidad humana'. El concepto de capital humano es mas limitado puesto que solo concibe las cualidades humanas en su relación con el crecimiento económico mientras que el concepto de capacidades da énfasis a la expansión de libertad humana para vivir el tipo de vida que la gente considera valedera. Cuando se adopta esa visión mas amplia, el proceso de desarrollo no puede verse si...

  11. LINGUAGEM E FORMAÇÃO HUMANA

    Directory of Open Access Journals (Sweden)

    Lílian do Valle

    2014-09-01

    Full Text Available  No que concerne à investigação sobre o ser humano e sobre a sociedade, a linguagem está sempre presente como cerne daquilo que deve ser pesquisado e fazendo ser as possibilidades e os limites do próprio pensamento: como, pois, ignorar a enorme relevância que adquire, para a reflexão sobre a formação humana? Aqui, a reflexão sobre a linguagem é essencial, já que é somente no terreno da linguagem que emerge o sujeito, como falante e como sensí-vel, como exigência de sentido, como poder de criação. Language and human formationLanguage is a relevant topic whenever it comes to investigating human being and society, as the core both of what should be researched andof the possibilities and limits of thought itself. How is it possible, thus, to ignore its significance for  education?  Such significance is considered essential, since it is only within this field that the subject, as a talkative and sensitive being, emerges in his quest for meaning, as power of creation.   

  12. DE NUEVO SOBRE LA DIGNIDAD HUMANA

    Directory of Open Access Journals (Sweden)

    Antonio-Carlos Pereira-Menaut

    2014-01-01

    Full Text Available De la Segunda Guerra Mundial en adelante, la dignidad humana es recogida en muchas constituciones, declaraciones de derechos y tratados internacionales. Esto no significa que sea un concepto nuevo, pues su significado puede rastrearse sin dificultad en la tradición judeo-cristiana y, mucho más tarde, en la influyente comprensión kantiana; y tampoco significa que no haya tenido relación con el Derecho antes de 1945. Por otro lado, las nuevas tendencias filosóficas y antropológicas así como la politización del hombre, junto con los avances de la técnica, explican su presencia cada vez mayor en el Derecho. Sin embargo, la inclusión de la dignidad en los textos jurídicos no es capaz de agotar su significado —ni aunque los textos sean los constitucionales—, y el hecho de que los jueces la aleguen no significa que la empleen realmente como criterio para su decisión, como puede verse al estudiar algunas sentencias relevantes.

  13. Adiaspiromicose pulmonar humana Human pulmonary adiaspiromycosis

    Directory of Open Access Journals (Sweden)

    Lina Gomes dos Santos

    2009-08-01

    Full Text Available A adiaspiromicose é uma doença fúngica sistêmica que acomete usualmente roedores e raramente atinge o homem. É causada pelo fungo Emmonsia crescens e ocorre após a inalação da forma contagiante (conídios. Embora estas formas não se multipliquem nem se disseminem no organismo humano, induzem uma reação inflamatória crônica granulomatosa de padrão miliar que pode levar a falência respiratória e morte. Apresentamos aqui um caso de adiaspiromicose pulmonar humana em paciente imunocompetente que exibia infiltrado intersticial pulmonar difuso ao exame de imagem e fora diagnosticado mediante biópsia pulmonar.Adiaspiromycosis is a systemic fungal disease that usually affects rodents and rarely infects humans. It is caused by the fungus Emmonsia crescens and occurs after inhalation of its contagious form (conidia. Although these forms neither multiply nor spread in the human body, they cause a chronic granulomatous inflammatory reaction of miliary pattern, which may lead to respiratory failure and death. In this study we present a case of human pulmonary adiaspiromycosis in an immunocompetent patient that showed a diffuse pulmonary interstitial infiltrate diagnosed by pulmonary biopsy.

  14. ACOG Committee Opinion No. 648: Umbilical Cord Blood Banking.

    Science.gov (United States)

    2015-12-01

    Once considered a waste product that was discarded with the placenta, umbilical cord blood is now known to contain potentially life-saving hematopoietic stem cells. When used in hematopoietic stem cell transplantation, umbilical cord blood offers several distinct advantages over bone marrow or peripheral stem cells. However, umbilical cord blood collection is not part of routine obstetric care and is not medically indicated. Umbilical cord blood collection should not compromise obstetric or neonatal care or alter routine practice for the timing of umbilical cord clamping. If a patient requests information on umbilical cord blood banking, balanced and accurate information regarding the advantages and disadvantages of public and private umbilical cord blood banking should be provided. The routine storage of umbilical cord blood as "biologic insurance" against future disease is not recommended.

  15. Committee Opinion No. 648 Summary: Umbilical Cord Blood Banking.

    Science.gov (United States)

    2015-12-01

    Once considered a waste product that was discarded with the placenta, umbilical cord blood is now known to contain potentially life-saving hematopoietic stem cells. When used in hematopoietic stem cell transplantation, umbilical cord blood offers several distinct advantages over bone marrow or peripheral stem cells. However, umbilical cord blood collection is not part of routine obstetric care and is not medically indicated. Umbilical cord blood collection should not compromise obstetric or neonatal care or alter routine practice for the timing of umbilical cord clamping. If a patient requests information on umbilical cord blood banking, balanced and accurate information regarding the advantages and disadvantages of public and private umbilical cord blood banking should be provided. The routine storage of umbilical cord blood as "biologic insurance" against future disease is not recommended.

  16. A Semicircular Incision in the Superior Umbilical Fold for SILS Preserves the Umbilical Profile

    Directory of Open Access Journals (Sweden)

    S. C. Blackburn

    2012-01-01

    Full Text Available Background. Single Incision Laparoscopic Surgery (SILS has been highlighted in the recent literature as a means of performing a range of common, minimal access, paediatric surgical procedures. The primary attraction is the absence of visible scarring. Aim. This study aims to describe a cosmetically advantageous means of SILS port placement in children, which preserves the umbilical profile. Methods. We describe a paediatric case series utilising a semicircular incision in the superior umbilical fold for SILS procedures. The linea alba is exposed over 2 cm just superior to the umbilical ring and stay sutures are applied. A vertical incision is made over this distance without entering the umbilical ring. Data were recorded prospectively in a Microsoft Excel database. Results. Twenty-one cases were performed in a 1-year period. Ten appendicectomies, 5 ovarian/paraovarian cystectomies, 2 Palomo procedures, 3 nephrectomy/heminephrectomies, and 1 Meckel’s diverticulectomy were performed. There was 1 wound infection. No incisional hernias occurred. Discussion. We believe that our technique, which maintains the integrity of the umbilical ring and allows preservation of the umbilical profile, offers a distinct cosmetic advantage over other incisions for SILS which distort it. Conclusion. We have demonstrated the aesthetic benefits of utilising a superior umbilical-fold incision for SILS in children.

  17. The Aberrant Right Subclavian Artery (Arteria Lusoria): The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    OpenAIRE

    Michał Polguj; Łukasz Chrzanowski; Kasprzak, Jarosław D.; Ludomir Stefańczyk; Mirosław Topol; Agata Majos

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinical...

  18. [Management of umbilical hernia in cirrhotic patients].

    Science.gov (United States)

    Loriau, J; Manaouil, D; Mauvais, F

    2002-06-01

    The treatment of umbilical hernia in the setting of cirrhosis poses unique and specific management problems due to the pathophysiology of cirrhotic ascites. The high intra-abdominal pressures generated by ascites when applied to areas of parietal weakness are the cause of hernia formation and enlargement. Successful surgical treatment depends on minimization or elimination of ascites. Umbilical rupture and hernia strangulation are the most life-threatening complications of umbilical hernia with ascites and they demand urgent surgical intervention. In non-emergency situations, medical therapy to control ascites should precede hernia repair. When ascites is refractory to medical therapy, treatment will vary depending on whether transplantation is an option. In liver transplantation candidates, hernia repair can be performed at the end of the transplantation procedure. If transplanation is not envisaged, concomitant treatment of both ascites and hernia is best achieved by placement of a peritoneo-venous shunt at the time of the parietal repair. PMID:12391663

  19. Totally contact umbilical lightlike hypersurfaces of indefinite Sasakian manifolds

    OpenAIRE

    Massamba, Fortuné

    2008-01-01

    This paper investigates totally contact umbilical lightlike hypersurfaces which are tangent to the structure vector field. Theorems on Killing distributions, geodesibility of lightlike hypersurfaces are obtained. The geometrical configuration of such lightlike hypersurfaces and its screen distributions are established. We prove the non-existence of totally contact umbilical lightlike hypersurfaces and lightlike hypersurfaces with totally contact umbilical screen distributions in indefinite Sa...

  20. VARIACIONES DE LA ARTERIA DEL NODO SINOATRIAL EN POBLACIÓN COLOMBIANA Sino-atrial node artery variation in a sample of the Colombian population

    Directory of Open Access Journals (Sweden)

    Yobany Quijano-Blanco

    2012-03-01

    Full Text Available Antecedentes. El conocimiento exacto de la integración anatomofisiológica del sistema de conducción del corazón, es fundamental para la comprender la fisiopatología, el diagnóstico y el manejo de muchas de las complicaciones de la enfermedad coronaria y de las cardiopatías en general. Uno de los aspectos fundamentales, más variable y con mayores repercusiones clínicas corresponde al origen y recorrido de las arterias encargadas de irrigar el nódulo sinoatrial. Objetivo. Determinar el origen, recorrido y distribución de las arterias que irrigan el nódulo sinoatrial en una muestra de población colombiana. Material y métodos. La muestra de análisis fueron 60 bloques cardiopulmonares y digestivos seleccionados a través de muestreo por conveniencia. A estos se les realizó una disección convencional de los genitales para la determinación del sexo y posteriormente se procedió con la disección de las arterias coronarias específicamente de la arteria del nódulo sinoatrial, con el fin de establecer su origen y recorrido. Resultados. Como hallazgo principal se encontró que el origen de la arteria del nódulo sinoatrial en 75% provenía de la coronaria derecha, un 15% procedía de la arteria circunfleja y el 10% restante fue codominante. En cuanto al trayecto 86,6% fueron lineales, mientras 13,4% tuvieron formas alternas como Y, doble Y o en tridente. Conclusiones. Se evidenció predominio del origen de la arteria del nódulo sinoatrial en la coronaria derecha, hallazgo coincidente con investigaciones similares e independiente de la procedencia geográfica y el origen racial. Sin embargo, en este estudio se evidenciaron recorridos no reportados en la literatura como la distribución en Y, en doble Y, en K invertida y en tridente.Background. Accurate knowledge regarding the cardiac conduction system's anatomical-physiological integration is essential for understanding the pathophysiology, diagnosis and management of many complications

  1. Porous nematic microfluidics for generation of umbilic defects and umbilic defect lattices

    Science.gov (United States)

    Aplinc, Jure; Morris, Stephen; Ravnik, Miha

    2016-06-01

    We demonstrate that porous nematic microfluidics is a potential route for the generation of nematic umbilic defects and regular umbilic defect lattices. By using numerical modeling we show that the mutual (backflow) coupling between the flow velocity and the orientation director field of the nematic liquid crystal leads to the formation of positive umbilic defects at local peaks and to the formation of negative umbilic defects at the local saddles in the flow profile. The number of flow peaks and the index of the flow saddles (i.e., the number of the valleys) are shown to be directly related to the strength of the umbilic defect, effectively relating the two fields at the geometrical level. The regular arrangement of the barriers in the porous channels is demonstrated to lead to the formation of regular lattices of umbilic defects, including square, triangular, and even kagome lattices. Experimental realization of such systems is discussed, with particular focus on microfluidic-tunable birefringent photonic band structures and lattices.

  2. Teoria organizacional para la gerencia humana como factor de desarrollo a escala humana

    Directory of Open Access Journals (Sweden)

    Gregoria Polo de Lobatón

    2014-01-01

    Full Text Available Hoy, se debate en los países subdesarrollados y hasta en desarrollo caso América Latina el estancamiento económico rodeado de un mar de pobreza y exclusión social, en contrario, los paísesdesarrollados a partir de la crisis de 1929 muestran su crecimiento a partir de modelos de desarrollo económico como sustento teórico del pensamiento administrativo captado para las prácticas gerenciales; resultó útil identificar los aportes de la teoría del desarrollo como fundamentación de las teorías organizacionales y su incidencia en las prácticas gerenciales como factor de desarrollo. Metodológicamente la investigación se orientó en el enfoque cualitativo para el análisis fenomenológico de los datos encontrados en revisiones documentales. Los resultados determinaron que las prácticas gerenciales se fundamentan en teorías organizacionales clásicas y contemporáneas centradas en principios de eficiencia y productividad. A partir de las teorías contemporáneas un dinamismo con enfoques sociales y ambientales, su fundamento la escuela humana con los pensadores: Weber, Elton Mayo, reformistas y otros pensadores, que tenidas en cuenta para las prácticas gerenciales centradas en la suficiencia manifiestan interés por el acercamiento al desarrollo a escala humana.Palabras clave: Teorías organizacionales; paradigma de Gerencia Humana; Desarrollo a escala humana.Organizational theory for human management as a development factor to human scale AbstractToday, there are discussions in underdeveloped countries and even in developing ones, Latin American case, the economic halt surrounded by a sea of poverty and social exclusion, in contrast, developed countries starting from the crisis of 1929 show their growth from economic development models as a theoretical backup of the management thinking captured for management practices; proved useful to identify the contributions of development theory as the foundation of organizational theories and

  3. Hidatidosis humana en el Perú

    Directory of Open Access Journals (Sweden)

    Luis Guerra Montero

    2015-06-01

    Full Text Available El objetivo de este trabajo ha sido conocer el estado de la hidatidosis humana, por la gran incidencia que presenta en nuestro país, principalmente en la región central andina. La recopilación de datos fue a partir de la revisión de fuentes primarias sobre epidemiología, el ciclo vital del parásito y del manejo del paciente afecto de Hidatidosis. Algunos hallazgos permiten afirmar que la hidatidosis es una enfermedad producida por el estado larval del cestodo Echinococcus del género Granulosus, de alta prevalencia en nuestro país y más en la región central andina, esto se debe principalmente a la costumbre de convivir con perros y ganado ovino así como también a la falta de educación y concientización de la población. Los estudios serológicos como Elisa IgG y Wester Blot por su mayor sensibilidad y especificidad son las pruebas de primera línea para confirmar el diagnóstico. Dependiendo del tamaño, las características del quiste hidatídico y su localización se decide el tratamiento. La hidatidosis es una enfermedad producida por el cestodo Echinococcus Granulosus de alta prevalencia en el Perú y más aún en la región central andina (Cerro de Pasco, Junín, Huancavelica, tiene un lento crecimiento dentro de los órganos humanos pudiendo ser asintomáticos hasta la edad adulta, los órganos más afectados son el hígado y el pulmón donde son diagnosticados por sus antecedentes epidemiológicos, clínica sugestiva (dolor abdominal, vómica estudios de imagen principalmente ecografía abdominal, radiografía de tórax y exámenes de laboratorio como el Elisa IgG y Wester Blot.

  4. Seguridad Humana: Aplicabilidad del concepto a la realidad colombiana

    Directory of Open Access Journals (Sweden)

    Camilo Andrés Devia-Garzón

    2016-09-01

    Full Text Available Este documento busca establecer la relación entre el concepto de Seguridad Humana y las realidades de Colombia. En una primer parte, muestra los principales aportes teóricos que desde el país se han realizado a la Seguridad Humana. Después se muestra la implementación del concepto a la práctica en Colombia. Finalmente se establece el contexto actual de Colombia y los retos que debe enfrentar en el potencial escenario de posconflicto desde la Seguridad Humana; mostrando que la finalización del conflicto armado hace necesaria la inclusión de otro tipo de dimensiones a la seguridad que mejoren las condiciones de la población y permitan un escenario real de paz.

  5. Evolución humana en Europa: registro y debates

    OpenAIRE

    Arsuaga, Juan Luis; Martínez, Ignacio; Carretero Díaz, José Miguel; Gracia Téllez, Ana; Lorenzo, Carlos; Bermúdez de Castro, José María

    1996-01-01

    Tres son los principales debates en los estudios de evolución humana en Europa: primer poblamiento de nuestro continente, patrón evolutivo durante el Pleistoceno medio, origen del Hombre moderno y su relación con los neandertales. Hasta la fecha, no existe consenso en admitir la presencia humana en Europa antes del episodio isotópico 13, pero el reciente hallazgo de fósiles humanos e industria lítica en ni veles del Pleistoceno inferior del yacimiento Gran Dolina (S ierra de Atapuerca), permi...

  6. Las necesidades humanas desde la psicología moral

    OpenAIRE

    Martí Vilar, Manuel

    2008-01-01

    En este texto se presentan las aportacionesde la psicología del desarrollo moral y de la prosocialidad a la reflexión sobre las necesidades humanas, especialmente en el contexto presente, haciendo especial hincapié en propuestas psicoeducativas con una solución positiva a la situación actual. La delimitación conceptual que se plantea pretende ayudar a entender aquellos términos que más se utilizan y que se consideran una buena aportación desde la psicología moral a las necesidades humanas. AB...

  7. Transferencia al sector social y empresarial de las ciencias humanas y sociales: entrevista

    OpenAIRE

    Unidad de Comunicación y Transferencia de Tecnología, Delegación del CSIC en Cataluña; Criado-Boado, Felipe

    2008-01-01

    Entrevista a Felipe Criado Boado, coordinador del área de Ciencias humanas y Sociales del CSIC, sobre las posibilidades de transferencia de conocimiento al ámbito empresarial desde las Ciencias humanas y sociales.

  8. Síndrome de atrapamiento de la arteria poplítea con aneurisma: reporte de un caso Popliteal entrapment syndrome caused by an aneurism: Case report

    Directory of Open Access Journals (Sweden)

    Tania Buccolini

    2010-06-01

    Full Text Available La verdadera prevalencia del síndrome de atrapamiento de la arteria poplítea es desconocida; se estima en un 0.16%. Se considera la principal causa de claudicación intermitente en jóvenes deportistas sin factores de riesgo cardiovasculares. Se caracteriza por la compresión extrínseca de la arteria poplítea, ya sea por defecto anatómico de las estructuras músculo-tendinosas o por hipertrofia de los músculos gemelos, lo cual ocasiona el atrapamiento y síntomas de parestesias, frialdad y claudicación intermitente en la extremidad comprometida. La compresión crónica de la arteria puede llevar a daño irreversible con formación de trombos y aneurismas y a la consiguiente amputación de la extremidad, por lo que el diagnóstico y el tratamiento oportunos son de gran importancia para el paciente.The true prevalence of the popliteal artery entrapment syndrome is unknown, it is estimated to be 0.16%. It is considered as the main cause of intermittent claudication in young athletes without cardiovascular risk factors. It is characterized by the extrinsic compression of the popliteal artery either caused by defects of the muscle-tendon structures or by the hypertrophy of the gastrocnemius muscle leading to the arterial entrapment and symptoms of paresthesia, intermittent claudication and coldness of the affected limb. Chronic compression of the artery may lead to irreversible damage with formation of thrombi and aneurysms and the subsequent amputation of the limb. Therefore, correct diagnosis and treatment are of great importance for the patient.

  9. Percutaneous ultrasound guided umbilical cord blood sampling

    International Nuclear Information System (INIS)

    This report describes a technique and the result of percutaneous ultrasound-guided umbilical cord blood sampling and its potential use in the management of diagnostic problems in the second and third trimester of pregnancy. This method has been employed in the prenatal assessment of 19 fetuses at risk for chromosomal disorders, fetal hypoxia and hematologic disorders. This simple and rapid procedure offers a safe access to the fetal circulation

  10. Capital humano y capacidad humana Human capital and human capacity

    Directory of Open Access Journals (Sweden)

    Sen Amartya Kumar

    1998-12-01

    Full Text Available En este articulo se examinan las relaciones y diferencias entre el concepto de 'capital humano' y el concepto de 'capacidad humana'. El concepto de capital humano es mas limitado puesto que solo concibe las cualidades humanas en su relación con el crecimiento económico mientras que el concepto de capacidades da énfasis a la expansión de libertad humana para vivir el tipo de vida que la gente considera valedera. Cuando se adopta esa visión mas amplia, el proceso de desarrollo no puede verse simplemente como un incremento del PIB sino como la expansión de la capacidad humana para llevar una vida mas libre y mas digna.In this article the relationships and the differences between the concept of 'human capital' and the concept of 'human capability' are examined. The concept of human capital is more limited since it only conceives human qualities in relation to economic growth, whereas the concept of capabili ties puts emphasis on the expansion of human freedom to live the kind of life that people judge valuable. Whenthis broader vision is adopted, the process of development cannot be seen as simply an increase in the GNP, but rather as the expansion of the human capability to live a more free and worthy life.

  11. Illusory Liberalism in "Atlas de Geografía Humana"

    Science.gov (United States)

    Ryan, Lorraine

    2014-01-01

    "Atlas de Geografía Humana" constitutes a critique of the much vaunted notion of a progressive Spain that has rectified the gender inequalities of the Francoist era, as one of the highly educated and successful protagonists, Fran, unwittingly adopts her mother's alignment with patriarchal norms. This novel elucidates the…

  12. Pulskurvenanalyse in der Arteria ophthalmica als Funktion von Alter, Geschlecht, kardio-vaskulärer Risikofaktoren, Glaukom, Verdacht auf Glaukom und okulärer Hypertension

    OpenAIRE

    Fiermann, Thomas

    2009-01-01

    Die Analyse der Pulskurvenform liefert direkte Informationen über die Gefäßbeschaffenheit an der Arteria ophthalmica und deren distalem Stromgebiet. Alter, Geschlecht, arterielle Hypertonie, Diabetes mellitus, Glaukome und Nikotinkonsum verändern die Pulskurvenform im Sinne einer „Voralterung“. Der SK und der SI könnten als Maß für die Bestimmung des biologischen Gefäßalters bei Männern und Frauen verwendet werden. Neben den bekannten Risiko-Scoren erweitert die SK- und SI-Berechnung die vask...

  13. Pseudoaneurisma de arteria renal principal asociado a fistula cecal tras nefrectomia radical: caso clínico y revisión de la literatura

    OpenAIRE

    A. Hernando Arteche; C. Alpuente Roman; R. Martin del Toro; A. Pérez-Piqueras Gómez; F. Sainz González; JA. Cabrera Cabrera

    2014-01-01

    Las complicaciones vasculares secundarias al tratamiento quirúrgico del cáncer de riñón localizado son más frecuentes cuando se realiza una cirugía conservadora de nefronas. Sin embargo, la nefrectomía radical no está exenta de ellas. Presentamos el caso de un pseudoaneurisma de la arteria renal principal con comunicación fistulosa a colon ascendente tras nefrectomía radical. El paciente debutó con un episodio de shock hipovolémico debido a hemorragia digestiva baja.

  14. Pseudoaneurisma de arteria renal principal asociado a fistula cecal tras nefrectomia radical: caso clínico y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    A. Hernando Arteche

    2014-06-01

    Full Text Available Las complicaciones vasculares secundarias al tratamiento quirúrgico del cáncer de riñón localizado son más frecuentes cuando se realiza una cirugía conservadora de nefronas. Sin embargo, la nefrectomía radical no está exenta de ellas. Presentamos el caso de un pseudoaneurisma de la arteria renal principal con comunicación fistulosa a colon ascendente tras nefrectomía radical. El paciente debutó con un episodio de shock hipovolémico debido a hemorragia digestiva baja.

  15. Pseudo-umbilical Biharmonic Submanifolds in Constant Curvature Spaces

    Institute of Scientific and Technical Information of China (English)

    DU Li; ZHANG Juan

    2012-01-01

    The conjecture [1] asserts that any biharmonic submanifold in sphere has constant mean curvature.In this paper,we first prove that this conjecture is true for pseudo-umbilical biharmonic submanifolds Mn in constant curvature spaces Sn+P(c)(c > 0),generalizing the result in [1].Secondly,some sufficient conditions for pseudo-umbilical proper biharmonic submanifolds Mn to be totally umbilical ones are obtained.

  16. Condi(aÇão Humana e Liberdade

    Directory of Open Access Journals (Sweden)

    Joelma Lúcia Vieira Pires

    2015-12-01

    Full Text Available RESUMO:O objeto de estudo deste artigo é a condição humana. Qual a possibilidade de existência da condição humana fundamentada na liberdade? O objetivo é relacionar esfera pública, política, liberdade e condição humana. A elaboração teórica considerou obras de Etienne de La Boétie, Hannah Arendt, Cornelius Castoriadis, entre outros. Na atualidade, ocorre a supressão da condição humana, pois a esfera pública tem a ingerência da esfera privada, predominando a razão instrumental e a lógica do mercado, e o homem é afastado da vida política. Por isso, a nossa ação política pela liberdade é fundamental para a problematização do processo de banalização do mal e da servidão voluntária. A coragem é uma virtude indispensável à ação política, é necessária para nos libertarmos da dominação e do servilismo da vida privada e conquistarmos a vida política. A centralidade da ação política do homem é a sua condição de ser atuante para a reafirmação da esfera pública, do mundo da pluralidade, humano e comum. Todavia, a condição humana fundamentada na liberdade implica a superação da atividade e do pensamento pragmáticos e fragmentários da vida cotidiana e a constituição da praxis na dimensão humano-genérica consciente.

  17. Postpartum deaths: piglet, placental, and umbilical characteristics.

    Science.gov (United States)

    Rootwelt, V; Reksen, O; Farstad, W; Framstad, T

    2013-06-01

    The fetal growth of the piglet is highly dependent on its placenta, and the newborn piglet birth weight is highly associated with postpartum death. However, there is little information available in the literature on the assessment of the placenta in relation to postpartum death in piglets. The aim of this study was to evaluate the impact of the placental area and placental weight, status of the umbilical cord, and piglet birth characteristics, such as blood parameters, vitality score, and birth weight on postpartum death. All live born piglets in litters from 26 Landrace-Yorkshire sows were monitored during farrowing and the status of each was recorded, including placental area and placental weight and blood variables obtained from the piglets and umbilical veins. Out of the 386 live-born piglets, 16.8% died before weaning at 5 wk. Among these, 78.5% died within the first 3 d of life. Mean blood concentration of lactate was increased in piglets that did not survive to weaning (P = 0.003). Concentrations of hemoglobin and hematocrit were decreased (P Piglets born with a broken umbilical cord had a reduced vitality score vs. piglets born with an intact umbilical cord (P = 0.021), and they had an increased probability of dying before weaning (P = 0.050). Mean birth weight, body mass index, placental area (P piglets that died before weaning vs. those that survived. Birth weight and placental area were furthermore negatively associated with live litter size. Blood concentrations of IgG and albumin recorded at d 1 were decreased in piglets that died before weaning (P < 0.01), and blood concentration of albumin was positively associated with placental area (P < 0.001). We conclude that placental area and placental weight, status of the umbilical cord, birth weight, body mass index, blood concentrations of lactate, hemoglobin, and hematocrit recorded at birth, and blood concentrations of IgG and albumin recorded at d 1 were associated with postpartum death in this study

  18. [Origin and development of umbilical therapy in traditional Chinese medicine].

    Science.gov (United States)

    Zhang, Xue-Wei; Jia, Hong-Ling

    2014-06-01

    The origin and development of umbilical therapy in traditional Chinese medicine is explored from related literature in the history. As a result, the Shang period is regarded as initial period of umbilical therapy, while periods from Han Dynasty, Jin Dynasty and Southern-Northern Dynasties to Sui Dynasty and Tang Dynasty could be taken as stage of primary development. Time from Song Dynasty, Jin Dynasty and Yuan Dynasty to Ming and Qing Dynasties is believed as mature stage. Also the manipulation, application principle, indications and contraindications of umbilical therapy are explained. A brief overview of modern development of umbilical therapy is also described. PMID:25112106

  19. Origen y morfología de la arteria braquial profunda en 14 cadáveres de la universidad de costa rica y de la universidad de ciencias médicas

    Directory of Open Access Journals (Sweden)

    Eduardo Delvo

    2012-09-01

    Full Text Available En este estudio se trata de observar la variabilidad del origen y morfología de la Arteria Braquial Profunda. Se utilizaron 14 cadáveres, a los cuáles se les midió el largo y diámetro de la Arteria Braquial Profunda antes de su bifurcación en Arteria Colateral Radial y Colateral Media en ambos brazos. El 21,4% presentó el origen de la Arteria junto con ramas musculares, el 14,3% de manera bilateral un origen común de la Arteria Braquial Profunda y la Arteria Circunfleja Humeral Posterior,el 7,2% una bifurcación temprana de la Arteria Braquial en Arterial Radial y Ulnar a nivel del tercio proximal del antebrazo y el 7,2% la misma variación a nivel del tercio medio. La longitud y diámetro de la Arteria en el estudio en promedio fue de 84,78 mm con un diametro de 1,66 mm en la izquierda y de 83,26 mm con un diametro de1,68 mm en la derecha, las diferencias presentadas no son estadísticamente significativas. El conocimiento de las diferencias anatómicas s de importancia en la practica clínica y quirúrgicaIn this review the objetive was to analize the variability of the origen and morphology of the Deep Braquial Artery. For it we used 14 bodies, in which we measure the lenght and diameter of the selected artery before the bifurcation of the radial collateral artery and medial collateral artery in both arms. The 21,4% of the cases the origen was presented along with the muscular branches, in the 14,3% was presented bilateral a common origen of Deep Braquial Artery and Posterior Humeral Circumflex Artery, in the 7,2% was presented an early bifurcation of Deep Braquial Artery in radial and ulnar at the third proximal of the forearm, in 7,2% the same modification was observed but at the middle third of the forearm. The lenght and diameter of the artery in promedy found was 84,78mm with a diameter of 1,66mm in the left side and 83,26mm with a diameter of 1,68mm in the right side, the diference found, were not of statiscally significant. The

  20. Aneurisma idiopático de la arteria pulmonar. Presentación de un caso y revisión de algunos aspectos clínicos.

    Directory of Open Access Journals (Sweden)

    Rafael Pila Pérez

    2011-10-01

    Full Text Available Se presenta el caso de un paciente masculino de 38 años de edad, fumador inveterado, con antecedentes de hipertensión arterial esencial, que ingresó en el Hospital Universitario Manuel Ascunce Doménech, de Camagüey, por presentar dolor precordial intenso. En la radiografía de tórax se encontró una imagen opaca bien delimitada a nivel parahiliar izquierdo, motivo por el cual se le practicaron diversas exploraciones complementarias como tomografía axial computarizada y ecocardiografía que revelaron la presencia de una dilatación aneurismática de la arteria pulmonar izquierda. El diagnóstico se concluyó como un aneurisma idiopático de la arteria pulmonar. Debido a que el paciente mejoró clínicamente y el tratamiento quirúrgico entrañaba mucho riesgo para su vida, se optó por el manejo conservador y control periódico.

  1. The Aberrant Right Subclavian Artery (Arteria Lusoria: The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    Directory of Open Access Journals (Sweden)

    Michał Polguj

    2014-01-01

    Full Text Available The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria. If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9±19.4 years for all patients but 54.0±19.6 years and 44.9±18.1 years for female and male subjects, respectively (P=0.0061. The most common symptoms in this group were dysphagia (71.2%, dyspnea (18.7%, retrosternal pain (17.0%, cough (7.6%, and weight loss (5.9%. The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%, Kommerell’s diverticulum (14.9%, aneurysm of the artery itself (12.8%, and a right sided aortic arch (9.2%. In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss.

  2. The Aberrant Right Subclavian Artery (Arteria Lusoria): The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    Science.gov (United States)

    Chrzanowski, Łukasz; Kasprzak, Jarosław D.; Stefańczyk, Ludomir; Topol, Mirosław; Majos, Agata

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9 ± 19.4 years for all patients but 54.0 ± 19.6 years and 44.9 ± 18.1 years for female and male subjects, respectively (P = 0.0061). The most common symptoms in this group were dysphagia (71.2%), dyspnea (18.7%), retrosternal pain (17.0%), cough (7.6%), and weight loss (5.9%). The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%), Kommerell's diverticulum (14.9%), aneurysm of the artery itself (12.8%), and a right sided aortic arch (9.2%). In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss. PMID:25105156

  3. The aberrant right subclavian artery (arteria lusoria): the morphological and clinical aspects of one of the most important variations--a systematic study of 141 reports.

    Science.gov (United States)

    Polguj, Michał; Chrzanowski, Łukasz; Kasprzak, Jarosław D; Stefańczyk, Ludomir; Topol, Mirosław; Majos, Agata

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9 ± 19.4 years for all patients but 54.0 ± 19.6 years and 44.9 ± 18.1 years for female and male subjects, respectively (P = 0.0061). The most common symptoms in this group were dysphagia (71.2%), dyspnea (18.7%), retrosternal pain (17.0%), cough (7.6%), and weight loss (5.9%). The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%), Kommerell's diverticulum (14.9%), aneurysm of the artery itself (12.8%), and a right sided aortic arch (9.2%). In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss. PMID:25105156

  4. Umbilicoplasty in children with huge umbilical hernia

    Directory of Open Access Journals (Sweden)

    Akakpo-Numado Gamedzi Komlatsè

    2014-01-01

    Full Text Available Background: Huge umbilical hernias (HUH are voluminous umbilical hernia (UH that are frequent in black African children. Several surgical techniques are used in their treatment for umbilical reconstruction, but techniques using skin flaps provide better aesthetic results. In this study, we presented our technique of umbilicoplasty in HUH, and its results. Patients and Methods: It is a retrospective study on children treated for HUH, from January 2012 to December 2013. The UH was called HUH when its basis diameter (BD exceeds 3 cm. Every HUH was characterised by its height, BD and morphology. Our technique was a two lateral flaps technique; the flaps are symmetrical and drawn so as to reconstitute the different parts of the umbilicus. The results were appreciated with criteria, including the peripheral ring and the central depression of the neo-umbilicus. Results : Twelve children were concerned (7 boys and 5 girls. Their mean age was 5 years and 6 months. The mean BD was 5.6 cm (extremes 3 and 8 cm, and the mean height of the HUH was 7.45 cm (extremes 3 and 9 cm. All underwent umbilicoplasty. In early post-operative period, two children presented a transitory subcutaneous hematoma. Late complications were granulation tissue with two children, and cheloid scar with one. With a mean follow-up of 10 months, we had 10 excellent results and two fair results according to our criteria. Conclusion: Our two lateral flaps umbilicoplasty is well-adapted to HUH in children. It is simple and assures a satisfactory anatomical and cosmetic result.

  5. CMS ECAL Endcap (EE) - Preparatory work for umbilical noise studies

    CERN Multimedia

    Lodge, T

    2007-01-01

    Possible mapping solution, done inside connector, top and bottom sides of MB MB with umbilical + free pins, all identical until position on Dee known Then pins to connector in specific order for that position. All SC umbilicals to mating connector identical.

  6. Histomorphometry of umbilical vessels of intrauterine growth restricted neonates

    Directory of Open Access Journals (Sweden)

    Sangeeta S. Kotrannavar

    2016-01-01

    Conclusions: IUGR is associated with significant structural changes in umbilical vessels of full term neonates. These changes are more obvious in HUV than human umbilical artery (HUA. It can be detected prenatally and used as an indicator of impending IUGR. [Int J Reprod Contracept Obstet Gynecol 2016; 5(1.000: 129-134

  7. vida humana: cuestiones de método

    Directory of Open Access Journals (Sweden)

    Antonio Pardo Caballos

    2007-01-01

    Full Text Available Para el estudio ético de las intervenciones sobre el comienzo de la vida humana es decisivo conocer cuándo comienza ésta exactamente. Para conseguir este resultado, es necesario combinar conocimientos fi losófi cos sobre la vida y observaciones empíricas de los primeros momentos del desarrollo. A partir de ellos, se puede realizar un razonamiento que permite mostrar que la fecundación establece el momento de aparición de una nueva vida humana. Las refl exiones estrictamente científi cas, y las que basan su razonamiento solamente en aspectos genéticos del comienzo de la vida, son reduccionistas y no pueden determinar propiamente el comienzo de la vida.

  8. La tarea hermenéutica de las ciencias humanas

    Directory of Open Access Journals (Sweden)

    Rafael Ávila Penagos

    2012-01-01

    Full Text Available En este trabajo el autor sustenta la importancia y pertinencia de la tradición hermenéutica para todos los investigadores de las ciencias humanas. Dos casos paradigmáticos sirven para abrir y cerrar el texto. En ellos se muestra, de manera contundente, el impacto de las actividades hermenéuticas sobre la configuración de nuevos sentidos, el cambio en las maneras de mirar y el acceso a nuevas formas de vida en el universo social. En el intermedio, el autor describe el progresivo distanciamiento de las ciencias humanas respecto al paradigma positivista. Se detiene en la conceptualización de cuatro categorías fundamentales de la actividad hermenéutica: la comprensión, la explicación, la interpretación y la traducción. Sostiene que la traducción del comprender es la tarea complementaria de la comprensión del comprender, e incorpora la propuesta de Paul Ricoeur para una nueva comprensión de la explicación en este ámbito. Finalmente, argumenta que la autocomprensión y la autovaloración de las ciencias humanas dependen de su capacidad reflexiva para considerar sus teorías y sus prácticas como textos susceptibles de autoexamen.

  9. Immunogenicity of umbilical cord tissue derived cells.

    Science.gov (United States)

    Cho, Patricia S; Messina, Darin J; Hirsh, Erica L; Chi, Nina; Goldman, Stephanie N; Lo, Diana P; Harris, Ian R; Popma, Sicco H; Sachs, David H; Huang, Christene A

    2008-01-01

    Umbilical cord tissue provides a unique source of cells with potential for tissue repair. Umbilical cord tissue-derived cells (UTCs) are MHC class I (MHCI) dull and negative for MHC class II (MHCII), but can be activated to increase MHCI and to express MHCII with IFN-gamma stimulation. Mesenchymal stem cells with similar characteristics have been inferred to be nonimmunogenic; however, in most cases, immunogenicity was not directly assessed. Using UTC from Massachusetts General Hospital MHC-defined miniature swine, we assessed immunogenicity across a full MHC barrier. Immunogenicity was assessed by in vitro assays including mixed lymphocyte reaction (MLR) and flow cytometry to detect serum alloantibody. A single injection of MHC-mismatched unactivated UTCs did not induce a detectable immune response. When injected in an inflamed region, injected repeatedly in the same region or stimulated with IFN-gamma prior to injection, UTCs were immunogenic. As clinical cellular repair strategies may involve injection of allogeneic cells into inflamed regions of damaged tissue or repeated doses of cells to achieve the desired benefit, our results on the immunogenicity of these cells in these circumstances may have important implications for optimal success and functional improvement for this cellular treatment strategy for diseased tissues. PMID:17909081

  10. ECTOPIC PANCREATIC, GASTRIC, AND SMALL INTESTINE TI SSUE IN AN UMBILICAL POLYP, CAUSING PERSISTENT UMBILICAL DISCH ARGE IN A 2 YEAR OLD CHILD – A RARE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sangeeta

    2013-01-01

    Full Text Available ABSTRACT: Umbilical polyps, containing vestigial remnants of th e omphalomesentric duct, are a rare cause of persistent umbilical discharge in th e paediatric age group, as compared to omphalitis or umbilical granulomas. However, umbilic al polyps need to be investigated thoroughly to ensure complete resection and to rule out extension into the abdominal cavity. Further, such umbilical polyps may cause complication s due to the presence of ectopic tissues inside them. The present case is the first reported c ase of three tissue types, viz. Pancreatic, Gastric, and Small Intestinal tissues, being present ectopically in an umbilical polyp, which had caused persistent umbilical discharge with severe lo cal excoriation and ulceration in a 2 year old child. CONCLUSION Umbilical polyps with ectopic tissues can lead to se vere complications if not treated properly, and should be ruled out in all cases of persistent umbilical discharge in the paediatric age group.

  11. Arteria poplitea afklemningssyndrom

    DEFF Research Database (Denmark)

    Lyndrup, Peter; Meyer, Joan N; Schroeder, T V

    1994-01-01

    Popliteal artery entrapment syndrome (PAES) should be suspected in young persons without predisposing factors to arteriosclerosis, who present with unilateral claudication in the calf and foot. This entity results from a developmental abnormal relation between the popliteal artery and the medial...... head of the gastrocnemius muscle. PAES is mostly found in young sportsmen or young soldiers with well-developed muscles. The onset of the symptoms is often sudden, occurring during an episode of intense lower extremity activity. The diagnosis is best established by a thorough clinical examination...

  12. Rupture of hepatic artery aneurysm associated with ischemic hepatitis Rotura de arteria hepática aneurismática asociada con hepatitis isquémica

    Directory of Open Access Journals (Sweden)

    V.M. Santos

    2010-08-01

    Full Text Available Hepatic artery aneurysms are scarcely reported, mainly because of non-specific symptoms. More often, they are incidental findings during imaging studies to investigate other acute or chronic abdominal conditions. These aneurysms are usually detected in the sixth decade of life, predominantly among males. We report the case of a 69 year-old female with an unsuspected huge hepatic artery aneurysm associated with ischemic hepatitis. Suspicion of aneurysm arose during imaging studies to clarify the origin of jaundice and abdominal pain. After establishment of the diagnosis, but before open surgery, there was a spontaneous rupture of the aneurysm, which caused hemoperitoneum and death. The necropsy study confirmed ischemic hepatitis. Hepatic artery aneurysms are second among the visceral aneurysms, and may cause abdominal pain, jaundice, and hemorrhagic events. One should suspect abdominal aneurysms in elderly patients with unclear abdominal pain, and this hypothesis should be ruled out by imaging studies.La publicación de trabajos sobre aneurismas en la arteria hepática es escasa, debido a los síntomas no específicos y a que constituyen hallazgos incidentales durante investigación de otras condiciones abdominales agudas o crónicas. Estos aneurismas son más frecuentes en varones y en la sexta década de la vida. Presentamos el caso de una mujer de 69 años de edad que ingresa en el hospital con un aneurisma de arteria hepática no sospechado previamente, asociado con hepatitis isquémica. La sospecha de aneurisma empezó durante estudio de imágenes para aclaramiento del origen de ictericia y dolor abdominal. Después de confirmado el diagnóstico, pero antes de la operación planeada, ocurrió rotura espontánea del aneurisma causando hemoperitoneo y muerte. El estudio de necropsia confirmó hepatitis isquémica. Los aneurismas de la arteria hepática son los segundos entre los aneurismas viscerales y pueden causar dolor abdominal, ictericia

  13. Evaluation of methods to test chemicals suitability for umbilical applications

    Energy Technology Data Exchange (ETDEWEB)

    Allenson, S. J.; Lindeman, O. E.; Cenegy, L. M.

    2006-03-15

    Offshore deep-water projects are increasingly deploying chemicals to sub-sea wellheads through umbilical lines. There is no margin for error in umbilical chemical treatment programs since any flow blockage in a sub-sea line would result in a multi-million dollar problem. Chemicals for umbilical delivery must also meet strict requirements in their performance and especially their handling properties. Umbilical delivery must be effective at low concentrations in preventing corrosion, scale, hydrates, asphaltenes, paraffin and a host of other problems. Chemical transiting an umbilical can experience pressures as high as 15,000 psi and temperatures ranging from near 0 deg C to greater than 120 deg C. Since some umbilicals are as long as 80 km, a week or more can elapse from the time the chemical is injected at the platform until it reaches the sub-sea well. Therefore, the chemical must not only be stable under all temperature and pressure conditions that it may experience in the umbilical line, it must also be stable under these conditions for a long period of time. Since many umbilical lines actually terminate into sub-sea valves and connectors that are only a few hundred microns in diameter, it is critical that the injected chemical have a low viscosity at sub-sea temperatures and pressures and that it be completely free of particles. These issues present substantial challenges in formulating and manufacturing chemicals for umbilical applications that must be addressed prior to approval of a product for use. Each of these challenges was taken into consideration and a series of tests were developed to assure reliable chemical pump ability through an umbilical line. The tests developed included enhanced formulation stability tests under umbilical temperature and pressure conditions, NAS Class rating, extensive material compatibility testing to include all metals and elastomers that may be used in umbilical injection systems and comprehensive physical property testing

  14. Umbilical properties of spacelike co-dimension two submanifolds

    CERN Document Server

    Cipriani, Nastassja; Van der Veken, Joeri

    2016-01-01

    For Riemannian submanifolds of a semi-Riemannian manifold, we introduce the concepts of \\emph{total shear tensor} and \\emph{shear operators} as the trace-free part of the corresponding second fundamental form and shape operators. The relationship between these quantities and the umbilical properties of the submanifold is shown. Several novel notions of umbilical submanifolds are then considered along with the classical concepts of totally umbilical and pseudo-umbilical submanifolds. Then we focus on the case of co-dimension $2$, and we present necessary and sufficient conditions for the submanifold to be umbilical with respect to a normal direction. Moreover, we prove that the umbilical direction, if it exists, is unique ---unless the submanifold is totally umbilical--- and we give a formula to compute it explicitly. When the ambient manifold is Lorentzian we also provide a way of determining its causal character. We end the paper by illustrating our results on the Lorentzian geometry of the Kerr black hole.

  15. Doppler ultrasound scan during normal gestation: umbilical circulation; Ecografia Doppler en la gestacion normal: circulacion umbilical

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, T.; Sabate, J.; Martinez-Benavides, M. M.; Sanchez-Ramos, J. [Hospital Virgen Macarena. Sevilla (Spain)

    2002-07-01

    To determine normal umbilical circulation patterns by means of Doppler ultrasound scan in a healthy gestating population without risk factors and with normal perinatal results, and to evaluate any occurring modifications relative to gestational age by obtaining records kept during pregnancy. One hundred and sixteen pregnant women carrying a single fetus have been studied. These women had no risk factors, with both clinical and analytical controls, as well as ultrasound scans, all being normal. There were performed a total of 193 Doppler ultrasound scans between weeks 15 and 41 of gestation, with blood-flow analysis in the arteries and vein of the umbilical cord. The obtained information was correlated with parameters that evaluate fetal well-being (fetal monitoring and/or oxytocin test) and perinatal result (delivery type, birth weight, Apgar score). Statistical analysis was performed with the programs SPSS 6.0.1 for Windows and EPIINFO 6.0.4. With pulsed Doppler, the umbilical artery in all cases demonstrated a biphasic morphology with systolic and diastolic components and without retrograde blood flow. As the gestation period increased, there was observed a progressive decrease in resistance along with an increase in blood-flow velocity during the diastolic phase. The Doppler ultrasound scan is a non-invasive method that permits the hemodynamic study of umbilical blood circulation. A knowledge of normal blood-flow signal morphology, as well as of the normal values for Doppler indices in relation to gestational age would permit us to utilize this method in high-risk pregnancies. (Author) 30 refs.

  16. Umbilical cord rupture: a case report and review of literature.

    Science.gov (United States)

    Naidu, Madhusudhan; Nama, Vivek; Karoshi, Mahantesh; Kakumani, Vijayasri; Worth, Richard

    2007-01-01

    The umbilical cord acts as a mechanical conduit between the fetus and placenta, allowing movement of water and nutrient substances between the fetal circulation and the amniotic fluid. Complications can occur antenatally or intranatally and are usually acute events that require immediate delivery to prevent intrauterine death. Even though the majority of the cord complications are unpreventable, significant improvement in perinatal mortality and morbidity can be achieved if such an event can be predicted. Umbilical cord rupture is not uncommon, but significantly underreported. We present an unusual cause of umbilical cord rupture and a review of literature. PMID:18320869

  17. Tensile Stiffness Analysis on Ocean Dynamic Power Umbilical

    Institute of Scientific and Technical Information of China (English)

    汤明刚; 阎军; 王野; 岳前进

    2014-01-01

    Tensile stiffness of ocean dynamic power umbilical is an important design parameter for functional implementation and structural safety. A column with radial stiffness which is wound by helical steel wires is constructed to predict the tensile stiffness value of umbilicals in the paper. The relationship between the tension and axial deformation is expressed analytically so the radial contraction of the column is achieved in the relationship by use of a simple finite element method. With an agreement between the theoretical prediction and the tension test results, the method is proved to be simple and efficient for the estimation of tensile stiffness of the ocean dynamic power umbilical.

  18. Resolución exitosa de la Estenosis Congénita de las dos ramas de la Arteria Pulmonar en un adulto mediante el uso de stents

    Directory of Open Access Journals (Sweden)

    José Solano V

    2013-06-01

    Full Text Available La estenosis de las arterias pulmonares son rara vez diagnosticadas en edad adulta, convirtiéndose su tratamiento en una compleja situación con diferentes posibilidades terapéuticas. Las causas mas frecuentes corresponden a las adquiridas, siendo la mas común la hipertensión pulmonar trombo embolica crónica, quedando un reducido numero de casos congénitos asociado principalmente a síndromes genéticos y malformaciones cardiacas asociadas. El tratamiento quirúrgico convencional puede convertirse en un desafío dadas las condiciones anatómicas y funcionales encontradas en estadios avanzados propias del diagnostico tardío y en especial en el caso presentado el cual esta iniciando la sétima década de la vida. La posibilidad de resolución percutánea de estas lesiones cobra importancia a la luz de la amplia utilización de esta en pacientes pediátricos, implementando el uso cada vez mayor de balones con dilatación percutánea y la utilización de stents cada vez más sofisticados con buenos resultados. Se presenta nuestro primer caso de resolución percutánea de lesiones coronarias y de arteria pulmonar bilateral en un paciente previamente programado para cirugía de reparación con parche y by pass coronario , el cual evoluciono en forma satisfactoria recobrando su actividad normal a las pocas horas del procedimiento.

  19. Embolización de la arteria esplénica como tratamiento del hiperesplenismo en pacientes hemofílicos, HIV-1 y HCV seropositivos

    Directory of Open Access Journals (Sweden)

    M. E. Corti

    2003-06-01

    Full Text Available La trombocitopenia es una anomalía usual e importante en pacientes con coinfección por HIV-1/HCV. La esplenomegalia es un hallazgo frecuente en estos pacientes y, usualmente, causa hiperesplenismo y trombocitopenia. Analizamos los resultados clínicos de un método invasivo mínimo (embolización de la arteria esplénica para el tratamiento de la trombocitopenia secundaria al hiperesplenismo y refractaria a otras terapias en dos pacientes hemofílicos, infectados por el HIV-1 y con cirrosis causada por la infección crónica por HCV. Estos resultados sugieren que la embolización de la arteria esplénica es un método seguro, poco traumático y efectivo para el tratamiento de la esplenomegalia y el hiperesplenismo en pacientes con coinfección por HIV-1/HCV.Thrombocytopenia is an important and common hematological abnormality in patients with HIV-1/HCV coinfection. Splenomegaly is a frequent finding in these patients and usually causes hypersplenism and thrombocytopenia. We analyzed the clinical results of a minimal invasive treatment (splenic artery embolization for thrombocytopenia secondary to hypersplenism and refractory to other therapies in two hemophiliac patients, HIV seropositive and with cirrhosis due to chronic HCV infection. The results suggest that splenic artery embolization is a safe, relatively atraumatic and effective method for the treatment of splenomegaly and hypersplenism in selected patients with HIV-1/HCV coinfection.

  20. Cibersociedad y ciencias humanas: el caso de la Historia Actual

    OpenAIRE

    Molina Rabadán, David; Fernandez-Garcia, Jesus

    2006-01-01

    La intención del presente artículo es presentar cómo los avances en el nuevo patrón de producción y difusión de conocimientos de la sociedad presente, ejemplificado en Internet, pueden influir en la reconceptualización de las ciencias humanas y en especial de la Historia Actual. Se analizarán los puntos de convergencia y divergencia de la práctica de la Historia Actual con los nuevos paradigmas intelectuales de la “tercera cultura”, y la posibilidad de que desde la filosofía y organización...

  1. Tratamiento contra la rabia humana: un poco de su historia

    OpenAIRE

    Maria Cristina Schneider; Carlos Santos-Burgoa

    1994-01-01

    El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de vene...

  2. O problema da natureza humana em Jacques Maritain

    OpenAIRE

    Névio de Campos

    2013-01-01

    Este artigo tem por objetivo discutir o problema da natureza humana em Jacques Maritain, destacando sua crítica ao humanismo antropocêntrico e a concepção do humanismo integral. Apoia-se na obra Humanismo Integral e nos debates da História Intelectual para problematizar a origem de seus escritos (contexto de produção) e a acepção de humanismo teocêntrico (História da Filosofia) proposta por esse filósofo tomista. Esta discussão permite-nos afirmar que o humanismo antropocêntrico é acusado por...

  3. CIENCIAS HUMANAS Y EMERGENCIA DE LA EDAD DIGITAL

    OpenAIRE

    Fischer, Hervé

    2013-01-01

    Estamos pasando de la era del fuego a la era digital, o sea, de la era de la energía, que incluye el fuego, el viento, el agua, la electricidad y la energía nuclear, a la era de la información. Pasamos así del binomio energía-materia a un nuevo paradigma epistemológico e instrumental, el de una codificación binaria y de una programación algorítmica con las cuales pretendemos reinterpretar el universo e instrumentarlo con una nueva potencia humana superior a la de las leyes habituales de la na...

  4. Antropologia Forense e Identificação Humana

    OpenAIRE

    Silva, Joana Trigo da Silva de Oliveira e

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A identificação de vítimas mortais é uma necessidade das sociedades, por razões jurídicas, sociais e humanitárias. A Antropologia Forense é uma das subdisciplinas da Antropologia Física que se dedica à identificação humana, nomeadamente em investigações arqueológicas, criminais e de desastres de massa. A Antropologia Forense...

  5. Unusual perforated appendicitis within umbilical hernia: CT findings.

    Science.gov (United States)

    Arnáiz, J; Ortiz, A; Marco de Lucas, E; Piedra, T; Jordá, J; Arnáiz, A M; Pagola, M A

    2006-01-01

    We present the first imaging report of perforated appendicitis in an umbilical hernia. Computed tomography demonstrated a gas-forming abscess within an umbilical hernia and the cecum was found inside the hernial sac, with an inner relation to the abscess. Computed tomographic findings suggested appendicitis as possible diagnosis, which was confirmed at surgery. Physicians must consider appendicitis within the differential diagnosis of an abdominal abscess located near to the cecum, even at an unexpected location. PMID:16465570

  6. Estudo retrospectivo da peste humana no Nordeste oriental do Brasil

    Directory of Open Access Journals (Sweden)

    Dalva A. Mello

    1970-02-01

    Full Text Available Utilizando dados do Departamento Nacional de Endemias Rurais, o autor faz um estudo retrospectivo da peste humana no Nordeste Oriental do Brasil no período de 1935-1967. Os aspectos epidemiológicos abordados foram os seguintes: morbidade, mortalidade, letalidade, "point" epidêmicos, tendência secular e variações mensais. Os coeficientes de morbidade e mortalidade variaram muito. A letalidade apresentou-se bastante alta. Dez anos de "point" epidêmicos foram registrados no periodo estudado. A análise estatística dos casos distribuídos por mês mostrou que a peste humana atinge o pcnto máximo na estação sêca. Ficou demonstrada urna variação cíclica da doença, em que aumentos e decréscimos ocorrem em períodos que variam de 6 a 12 anos.

  7. Exposición humana a disruptores endocrinos

    Directory of Open Access Journals (Sweden)

    A. Rivas

    2004-01-01

    Full Text Available Numerosos estudios han asociado las patologías observadas en distintas especies animales y en el hombre con la exposición a contaminantes medio ambientales con actividad hormonal. Se ha acuñado el término de disruptores endocrinos (Endocrine Disrupting Chemicals / EDCs para definir el conjunto de compuestos químicos que interaccionan con el sistema endocrino, sobre el que inducen efectos potencialmente debidos a su capacidad para:1 mimetizar la acción de las hormonas endógenas; 2 antagonizar la acción de las hormonas; 3 alterar su patrón de síntesis y metabolismo; o bien 4 modular los niveles de los receptores correspondientes.La exposición humana a disruptores endocrinos es universal y puede provenir de numerosas fuentes. Además, los compuestos acumulados en la grasa son transmitidos a la descendencia a través de la madre durante la gestación y después de la lactancia.Los efectos sobre la salud humana de la exposicición continua a los disruptores endocrinos necesitan ser investigados en más profundidad.

  8. Single umbilical artery in fetopathological investigations.

    Science.gov (United States)

    Joó, József Gábor; Beke, Artúr; Papp, Zoltán; Rigó, János; Papp, Csaba

    2008-01-01

    Single umbilical artery (SUA) is a relatively common malformation that may call attention to the possibility of associated malformations (often chromosome aberrations). The current study aimed at surveying malformations associated with SUA on the basis of fetopathological investigations, analyzing the role of history, summarizing the clinically important factors emerging together with this malformation. In this study, we processed the details of 204 cases in which SUA was confirmed fetopathologically after miscarriage or induced abortion between 1990 and 2007. In our sample, SUA occurred in 7.38% of the cases. The history was positive in almost 30% of the cases. The majority of the cases had a positive obstetric and the minority of them a positive genetic history. The highest association of SUA with other malformations was found for craniospinal ones, but an association with cardiovascular malformations should also be mentioned. Regarding the individual types of malformation, SUA was most commonly associated with hydrocephalus, but Potter's sequence, trisomy 21, and atrioventricular septal defect also reached a higher rate in associated SUA. Previously published articles dealing with associated malformations found that urogenital malformations were most commonly associated with SUA. 'Itemizing' the different non-chromosomal malformations in association with SUA, we found that hydrocephalus, Potter's sequence, and atrioventricular septal defect were the most frequent malformations, while in earlier studies, the association with non-chromosomal malformations such as vertebral malformations, imperforated anus, cheilognathopalatoschisis, and renal agenesis occurred more frequently than usual.

  9. Umbilical cord blood mercury levels in China

    Institute of Scientific and Technical Information of China (English)

    Meiqin Wu,; Chonghuai Yan; Jian Xu; Wei Wu; Hui Li; Xin Zhou

    2013-01-01

    Mercury (Hg) is a well-known neurotoxicant.Hg exposure at high levels can harm individuals of all ages.Even low level exposure to Hg can damage the brain of fetuses and young children,and affect their central nervous system and cognitive development.The aims of our study were to measure total Hg levels in infant umbilical cord blood and to investigate the risk factors associated with total Hg cord blood levels in various cities in China.Our goal was to provide clues for the prevention of Hg exposure in utero.The results indicated that the average cord blood mercury levels (CBMLs) were (1.81 ± 1.93) μg/L,which were lower than those found in most previous studies.The concentrations also differed according to geographic region.The CBMLs were not only associated with family economic and living conditions,but also with diet in pregnant women,especially the intake of marine fish,shellfish,poultry,formula milk and fruits.

  10. Determinación de las características anatómicas de las arterias coronarias de cerdo mediante técnica de inyección con látex

    Directory of Open Access Journals (Sweden)

    Guillermo Rivera

    2015-06-01

    Full Text Available Objetivo: Determinar las características anatómicas de las arterias coronarias del cerdo, mediante inyección con látex. Materiales y métodos: Se usaron 100 corazones de cerdo. Se insertaron sondas Nelaton a través de las arterias coronarias y se les inyectó solución de látex y tinta china. Se determinó el diámetro y el punto de origen para la coronaria derecha, coronaria izquierda, interventricular paraconal y circunfleja. Se cuantificaron el número de ramas diagonales, marginales ventriculares izquierdas y postero laterales. Se determinó frecuencia de ramus intermedius y tipo de dominancia. Se realizó análisis estadístico con un error estándar del 5%, con el Epidat 3,1. Resultados: El 100% de los orígenes anatómicos de las arterias coronarias fueron normales. La dominancia mas frecuente fue la derecha, 73%. El promedio de número de ramas marginales izquierdas, diagonales y posterolaterales fue de 3. La frecuencia de ramus intermedius fue de 12%. El calculo de chi cuadrado de Pearson mostró significancia entre el ramus intermedius y número de ramas marginales izquierdas (p=0,0009. Conclusiones: Las características anatómicas de las arterias coronarias del cerdo son similares a las del humano. El ramus intermedius se comporta como una primera rama marginal izquierda y no como una primera rama diagonal como lo afirman algunos autores.

  11. Tratamiento de la compresión del tronco de la arteria coronaria izquierda en pacientes con hipertensión pulmonar Treatment of compression of the left main coronary artery in patients with pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    María L. Talavera

    2011-10-01

    Full Text Available La angina de pecho es un síntoma frecuente en pacientes con hipertensión pulmonar (HP de cualquier etiología. Aunque su fisiopatología no está aclarada, las causas propuestas son: la isquemia subendocárdica por aumento del estrés parietal del ventrículo derecho, la dilatación de la arteria pulmonar por incrementos transitorios de la presión pulmonar y la compresión extrínseca del tronco de la arteria coronaria izquierda (TCI por la arteria pulmonar (AP dilatada. Se presentan tres casos que muestran la relación entre la angina de pecho y la compresión del TCI en pacientes con HP asociada a cardiopatías congénitas, tratados mediante implante de stent coronario.Chest pain is a frequent symptom in patients with pulmonary hypertension of any etiology. Its pathophysiology has not been clearly established, the proposed causes are ischemia due to increased right ventricle wall stress, transient increased pulmonary hypertension resulting in acute pulmonary artery dilatation and external compression of the left main coronary artery (LMCA by a dilated pulmonary artery. We report and discuss here three cases where the association between chest pain and compression of the LMCA by a dilated pulmonary artery could be shown, and they were treated with coronary stenting.

  12. Presencia de residuos y contaminantes en leche humana

    Directory of Open Access Journals (Sweden)

    Prado Flores Guadalupe

    2002-01-01

    Full Text Available La contaminación de la leche humana por xenobióticos es un problema generalizado a nivel mundial, que se ve afectado por las variaciones geográficas, climáticas, culturales y socioeconómicas de cada lugar. Las políticas de salud pública han enfrentado la situación mediante una vigilancia sostenida y legislaciones restrictivas con el objeto de reducir los efectos perjudiciales sobre las poblaciones y el ambiente, sin embargo se registran datos objetivables, sobre todo en los países en desarrollo. En esta revisión se destacan aspectos generales y particulares de los residuos y contaminantes organoclorados, organofosforados, antibióticos, metales pesados, bifenilos policlorados, dioxinas y furanos, valores de sus contenidos, efectos tóxicos estudiados y los límites máximos permitidos por las legislaciones internacionales.

  13. PRESENCIA DE RESIDUOS Y CONTAMINANTES EN LECHE HUMANA

    Directory of Open Access Journals (Sweden)

    Guadalupe Prado Flores

    2002-01-01

    Full Text Available La contaminación de la leche humana por xenobióticos es un problema generalizado a nivel mundial, que se ve afectado por las variaciones geográficas, climáticas, culturales y socioeconómicas de cada lugar. Las políticas de salud pública han enfrentado la situación mediante una vigilancia sostenida y legislaciones restrictivas con el objeto de reducir los efectos perjudiciales sobre las poblaciones y el ambiente, sin embargo se registran datos objetivables, sobre todo en los países en desarrollo. En esta revisión se destacan aspectos generales y particulares de los residuos y contaminantes organoclorados, organofosforados, antibióticos, metales pesados, bifenilos policlorados, dioxinas y furanos, valores de sus contenidos, efectos tóxicos estudiados y los límites máximos permitidos por las legislaciones internacionales.

  14. Notas sobre o autotelismo discursivo em ciências humanas

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Lopes

    1994-12-01

    Full Text Available O Ateliê de Semiótica Discursiva, coordenado por Denis Bertrand, propôs focalizar, no ano letivo 1991-1992, a " Estética do Discurso Erudito", no quadro da temática "Estética da Ética" do Seminário de Semântica Geral, de A.J . Greimas, na Escola de Altos Estudos em Ciências Sociais de Paris (E. H. E. S. S.. Bertrand distribuiu cópias de trechos de textos célebres em ciências humanas (Lévi-Strauss, Deleuze e Guattari, Greimas, Barthes, Foucault e outros, sobre os quais os participantes deveriam realizar análises que tomassem como modelo, por exemplo, aquelas praticadas por Greimas e Landowski em lntroduction à L 'Analyse du Discours en Sciences Sociales ( 1979.

  15. A precariedade humana e a existência estilizada

    Directory of Open Access Journals (Sweden)

    Rita Paiva

    2013-04-01

    Full Text Available Este artigo tematiza o desamparo vivenciado pela consciência ante a ausência de bases sólidas para seus anseios de felicidade e para suas representações simbólicas. Com esse propósito, toma como objeto de reflexão um dos ensaios filosóficos de Albert Camus, O mito de Sísifo, equacionando a possibilidade de uma ética que estilize a vida, sem que se minimize a dolorosa precariedade da existência humana. Posteriormente, em diálogo com alguns textos de M. Foucault, a reflexão procura estabelecer os vínculos possíveis entre a ética camusiana e a ética como uma estética da existência, tal como pensada entre os gregos antigos.

  16. Colgajos de perforantes de las arterias epigástricas inferiores profunda y superficial Deep and superficial inferior epigastric artery perforator flaps

    Directory of Open Access Journals (Sweden)

    A. R. Gagnon

    2006-12-01

    Full Text Available Con el desarrollo de los colgajos miocutáneos de recto abdominal (TRAM, el abdomen inferior ha sido reconocido como la principal área dadora de tejidos autólogos de alta calidad, especialmente útiles en reconstrucción mamaria. Más recientemente la habilidad para obtener componentes adiposocutáneos similares sin sacrificar el músculo recto ha revolucionado el campo de la Cirugía Reconstructiva. El advenimiento de los colgajos de perforantes ha permitido a los cirujanos plásticos lograr los mismos buenos resultados estéticos que con los colgajos miocutáneos tradicionales, pero con un considerable descenso en la morbilidad del área donante. Con los colgajos de perforantes de la arteria epigástrica inferior profunda (DIEP y de la arteria epigástrica inferior superficial (SIEA, los pacientes han incrementado sus opciones de reconstrucción. Este artículo revisa la anatomía quirúrgica de la pared abdominal relativa a los colgajos SIEA y DIEP. Se explican detalladamente los pasos principales para la preparación preoperatoria, la técnica quirúrgica y los cuidados postoperatorios. Se discuten las ventajas y desventajas y se presen- tan los trucos técnicos que pueden ayudar a mejorar el resultado final. Además se ilustran con ayuda de casos clínicos las indicaciones típicas y atípicas.Following the development of the transverse rectus abdominis myocutaneous (TRAM flap, the lower abdomen has been recognized as a prime source of high quality autogenous tissue, especially useful in breast reconstruction. More recently, the ability to harvest a similar adipocutaneous component without sacrifice of the rectus muscle has revolutionized the field of reconstructive surgery. The advent of perforator flaps has allowed plastic surgeons to achieve the same highly esthetic results as with the former myocutaneous flaps while significantly decreasing the donor site morbidity. With the deep inferior epigastric artery perforator (DIEP flap and

  17. Umbilical cord blood: a guide for primary care physicians.

    Science.gov (United States)

    Martin, Paul L; Kurtzberg, Joanne; Hesse, Brett

    2011-09-15

    Umbilical cord blood stem cell transplants are used to treat a variety of oncologic, genetic, hematologic, and immunodeficiency disorders. Physicians have an important role in educating, counseling, and offering umbilical cord blood donation and storage options to patients. Parents may donate their infant's cord blood to a public bank, pay to store it in a private bank, or have it discarded. The federal government and many state governments have passed laws and issued regulations regarding umbilical cord blood, and some states require physicians to discuss cord blood options with pregnant women. Five prominent medical organizations have published recommendations about cord blood donation and storage. Current guidelines recommend donation of umbilical cord blood to public banks when possible, or storage through the Related Donor Cord Blood Program when a sibling has a disease that may require a stem cell transplant. Experts do not currently recommend private banking for unidentified possible future use. Step-by-step guidance and electronic resources are available to physicians whose patients are considering saving or donating their infant's umbilical cord blood. PMID:21916391

  18. Mujeres y dignidad humana. Antecedentes en el Sistema Interamericano y en el Derecho constitucional de Colombia

    Directory of Open Access Journals (Sweden)

    Viviana Bohórquez Monsalve

    2010-01-01

    Full Text Available El texto analiza la aplicación del derecho a la dignidad humana en casos relacionados con los derechos humanos de las mujeres. Primero se indaga por los principales instrumentos interamericanos que protegen la dignidad humana. Posteriormente se estudian los alcances y las limitaciones de los informes de la Comisión Interamericana y la jurisprudencia de la Corte Interamericana. En tercer lugar se presenta la postura de la Corte Constitucional de Colombia en casos de mujeres relacionados con los postulados internacionales. Finalmente, se presentan algunas conclusiones acerca del alcance y efectividad del derecho a la dignidad humana de las mujeres.

  19. El sentido de la vida humana en adultos mayores : enfoque socioeducativo

    OpenAIRE

    Acosta Ocampo, Cilia Inés

    2011-01-01

    Esta tesis doctoral: "El Sentido de la Vida Humana, un enfoque Socioeducativo" es fruto de una persistente reflexión desde la propia existencia del complejo, misterioso y profundo fenómeno de la Vida Humana. Se lleva a cabo con el método fenomenológico como el camino para afrontar la problemática pregunta por el Sentido de la Existencia Humana, en estos tiempos, en la última etapa vital del ser humano y ante la inminencia de la muerte. La primera parte del trabajo está compuesta por la Fundam...

  20. Manejo de lesión traumática de arteria femoral con injerto autólogo de vena safena en zona de operaciones

    Directory of Open Access Journals (Sweden)

    M. Gascón Hove

    2015-03-01

    Full Text Available Tanto en el ámbito civil como en el militar, las lesiones vasculares de las extremidades inferiores son frecuentes y potencialmente mortales. Las medidas de soporte iniciales para combatir el shock, una actitud quirúrgica técnicamente correcta encaminada a reparar precozmente la vascularización del miembro y un control postoperatorio estricto y continuo son los pilares básicos del tratamiento. En condiciones óptimas, las tasas de amputación y de mortalidad se hallan por debajo del 10 y del 4%, respectivamente. Presentamos a continuación un caso de un militar afgano con una lesión con pérdida de substancia de la arteria femoral en el que se consiguió una revascularización inicial con un shunt temporal. Tras ser estabilizado y evacuado al ROLE 2 de Herat, se realizó un injerto autólogo de la vena safena contralateral.

  1. Umbilical Cord Serum Erythropoietin Levels and Maternal Smoking in Pregnancy

    Directory of Open Access Journals (Sweden)

    Soner Sazak

    2012-01-01

    Full Text Available Objective. To evaluate the effect of maternal smoking during pregnancy on levels of umbilical cord erythropoietin. Methods. Erythropoietin levels were measured in umbilical cord sera of 60 newborns who were delivered vaginally at term. There were 20 (33% smoking and 40 (67% nonsmoking mothers. Results. Mean cord serum erythropoietin levels were significantly lower in the nonsmokers (nonsmokers, 24 ± 9 IU/L; smokers, 61 ± 46 IU/L; P<.001. There was a significant positive correlation between the number of cigarettes smoked per day and cord serum erythropoietin levels (r, 0.58; P≤.05. Conclusions. Smoking during pregnancy is associated with increased levels of umbilical cord erythropoietin at birth. This may indicate a risk of fetal hypoxia and growth restriction. Education and encouragement of cessation of smoking during pregnancy are important to avoid associated fetal and maternal morbidity and mortality.

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    Lifescience Database Archive (English)

    Full Text Available Pol.Bld.05.AllAg.Umbilical_cord_blood hg19 RNA polymerase Blood Umbilical cord blood... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.Bld.05.AllAg.Umbilical_cord_blood.bed ...

  4. File list: His.Bld.20.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Bld.20.AllAg.Umbilical_cord_blood hg19 Histone Blood Umbilical cord blood http:...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.Bld.20.AllAg.Umbilical_cord_blood.bed ...

  5. ABSENT DUCTUS VENOSUS WITH SINGLE UMBILICAL ARTERY: A RARE ASSOCIATION

    Directory of Open Access Journals (Sweden)

    Satyabhuwan Singh

    2015-04-01

    Full Text Available Absent ductus venosus is a rare anomalous venous connection in fetus where the fetal outcome depends on type of venous connection and associated anomalies. Poor outcome is reported where the umbilical vein directly drains in to Rt atrium bypassing liver. Better resolution of ultrasound with C olor Doppler makes possible to detect the anomaly early. Here we are presenting a case of antenataly diagnosed absent ductus venous with umbilical vein directly draining in to Rt atrium bypassing liver. Case was diagnosed by Ultrasonography with color Doppler and MRI study.

  6. Dielectric properties of human placenta, umbilical cord and amniotic fluid

    Energy Technology Data Exchange (ETDEWEB)

    Peyman, A [Physical Dosimetry Department, Health Protection Agency, Chilton, Didcot OX11 0RQ (United Kingdom); Gabriel, C [MCL-P, Newbury RG14 5PY, Berkshire (United Kingdom); Benedickter, H R; Froehlich, J, E-mail: Azadeh.peyman@hpa.org.uk [Electromagnetic Fields and Microwave Electronics Laboratory, Swiss Federal Institute of Technology, Zurich (Switzerland)

    2011-04-07

    The dielectric properties of freshly delivered human placenta, umbilical cord and amniotic fluid have been acquired at 37 deg. C and in the frequency range of 200 MHz-10 GHz. The experimental data were fitted to a Cole-Cole expression. The results show that dielectric properties of the umbilical cord are significantly higher than placenta due to the presence of high water content Wharton's jelly. The results also demonstrate large differences in the dielectric properties of amniotic and cerebrospinal fluids. The data presented can be used in numerical simulations of the exposure of pregnant women to electromagnetic fields. (note)

  7. Dielectric properties of human placenta, umbilical cord and amniotic fluid

    Science.gov (United States)

    Peyman, A.; Gabriel, C.; Benedickter, H. R.; Fröhlich, J.

    2011-04-01

    The dielectric properties of freshly delivered human placenta, umbilical cord and amniotic fluid have been acquired at 37 °C and in the frequency range of 200 MHz-10 GHz. The experimental data were fitted to a Cole-Cole expression. The results show that dielectric properties of the umbilical cord are significantly higher than placenta due to the presence of high water content Wharton's jelly. The results also demonstrate large differences in the dielectric properties of amniotic and cerebrospinal fluids. The data presented can be used in numerical simulations of the exposure of pregnant women to electromagnetic fields.

  8. Dielectric properties of human placenta, umbilical cord and amniotic fluid

    International Nuclear Information System (INIS)

    The dielectric properties of freshly delivered human placenta, umbilical cord and amniotic fluid have been acquired at 37 deg. C and in the frequency range of 200 MHz-10 GHz. The experimental data were fitted to a Cole-Cole expression. The results show that dielectric properties of the umbilical cord are significantly higher than placenta due to the presence of high water content Wharton's jelly. The results also demonstrate large differences in the dielectric properties of amniotic and cerebrospinal fluids. The data presented can be used in numerical simulations of the exposure of pregnant women to electromagnetic fields. (note)

  9. Estudio psicométrico de la prueba figura humana

    Directory of Open Access Journals (Sweden)

    Marhilde Sánchez de Gallardo

    2012-05-01

    Full Text Available La investigación tuvo como objetivo determinar las propiedades psicométricas de la prueba proyectiva Test de la figura humana (Machover, 1976, administrada en la exploración aptitudinal de los aspirantes a cursar estudios en la mención orientación, una de las diez menciones de la carrera Educación, en La Universidad el Zulia, Venezuela. Se utilizaron como autores principales Cohen y Swerdlik (2006, Hogan (2004, Larsen y Buss (2005 y Shaughnessy, Zechmeister y Zechmeister (2007. La metodología fue descriptiva, de campo, diseño no experimental. La prueba se aplicó a 559 personas, 484 de sexo femenino y 75 de sexo masculino, con edades entre 17 a 47 años. El coeficiente de fiabilidad obtenido con el método de la división por mitades fue de 0,77 interpretado medio alto, lo cual indica que el test es fiable, es decir existe correlación entre las mitades y los ítemes de cada una de las partes de la prueba. La confiabilidad interobservadores, efectuada por tres evaluadores independientes, resultó en un coeficiente de 0.87 la cual se interpreta como alta. Para determinar la validez de la prueba se utilizó la de constructo, con el índice de consistencia interna, encontrándose un valor de 0,51, que indica poca relación entre los diferentes aspectos medidos por la prueba, lo cual demuestra heterogeneidad de estos elementos. Se construyó un baremo local y se obtuvieron las normas de interpretación para la población mencionada. Se concluye que el test de la figura humana tiene fiabilidad y validez, sus resultados son consistentes y el instrumento mide el constructo que se pretende medir, recomendándose la utilización de las normas obtenidas para la interpretación de resultados.

  10. Relationship between newborn Acid-Base status and umbilical cord morphology

    Directory of Open Access Journals (Sweden)

    Marssosi V

    2001-06-01

    Full Text Available ess the relationship between umbilical cord blood gases at birth and morphology of umbilical cord, in a prospective study of 200 consecutive term delivery, we investigated the relationship between umbilical cord morphology characteristics (umbilical crd length, number of vascular coil, coiling index and color of amniotic fluid and umbilical vessel blood gases. Statistically significant linear correlation was found between umblicial venous PH and the umbilical cord length (r=0.39, 95% CI 0.25, 0.53, P<0.03, umber of vascular coils (r=0.45 95% CI 0.31-0.59 P<0.012, and coiling index (r=0.34, 95% CI 0.12-0.48, P<0.04, and also negative linear correlation was found between umbilical venous partial pressure of carbon dioxide & of coli (r=0.3, 95% CI –0.44, -0.16 P<0.03. No relation was found between umbilical cord indices and meconium staining of amniotic fluid.Placental weight also correlated with umbilical cord length (r=0.17, 95% CI 0.03-0.31, P<0.03, but not with umbilical cord coils or coiling index.Umbilical venous pH is related to umbilical cord morphology but umbilical venous PCO2 was only related to the number of coils and umbilicat artery pH wa only related to the number of coils and not related to length or coiling index of umbilical cord morphology. The morphology of umbilical cord can affect maternal-fetal gas exchange

  11. El significado del éxito reproductivo en poblaciones humanas

    Directory of Open Access Journals (Sweden)

    Crognier, Emile

    2003-01-01

    Full Text Available Para la sociobióloga, el éxito reproductivo a sido desde el principio, la medida universal del valor adaptivo. La noción es muy discutible, considerando que se trata de una estimación individual, inapropiada a evaluar el valor selectivo de un (supuesto genotipo, pero a pesar de su inadecuación y de la simplificación de su evaluación en la mayoridad de los estudios, el éxito reproductivo permanezco una medida muy popular. En el caso de las poblaciones humanas, su medida tuvo que ser aun más simplificada para tomar en cuenta la larga extinción de las generaciones, hasta ser el número de descendientes sobreviviendo hasta madurez sexual. Sin embargo, su definición aun no logro de ser ni precisa ni satisfactoria y los últimos trabajos parecen indicar que así como el coeficiente de consanguinidad, su significado se revela en la profundidad de la sucesión de las generaciones. Se discuta este tema, apoyándose en datos de grupos Beraber de Marueccos y Aymara de Bolivia

  12. CIENCIAS HUMANAS Y EMERGENCIA DE LA EDAD DIGITAL

    Directory of Open Access Journals (Sweden)

    Fischer, Hervé

    2013-06-01

    Full Text Available Estamos pasando de la era del fuego a la era digital, o sea, de la era de la energía, que incluye el fuego, el viento, el agua, la electricidad y la energía nuclear, a la era de la información. Pasamos así del binomio energía-materia a un nuevo paradigma epistemológico e instrumental, el de una codificación binaria y de una programación algorítmica con las cuales pretendemos reinterpretar el universo e instrumentarlo con una nueva potencia humana superior a la de las leyes habituales de la naturaleza. El hombre ha escogido marcar con su sello nuestra evolución y hablamos aquí de lo antropoceno. McLuhan fue el último gran pensador de la era del fuego, de los medios de difusión eléctricos; pero no podría ser el nuevo gurú de la era digital. La energía destruye le información. Lo digital la crea y la difunde.

  13. El zinc, micronutriente importante en la salud humana

    Directory of Open Access Journals (Sweden)

    Alicia Velázquez Pérez

    2014-08-01

    Full Text Available La importancia biológica del zinc fue admitida por primera vez hace más de un siglo y en la actualidad continúan los estudios que avalan su valor en la nutrición humana. Se ha comprobado que la falta de zinc es bastante frecuente en la población de los países en vías de desarrollo, sobre todo en edades pediátricas, y se asocia en general a malnutrición y deficiencias de otros micronutrientes. El diagnóstico de la deficiencia leve de zinc en el hombre es difícil, ya que produce muchos síntomas clínicos inespecíficos. Por todo ello se realizó una revisión bibliográfica, para contribuir a incrementar los conocimientos del personal médico sobre su importancia, alimentos donde se puede encontrar, patologías en las que más está indicado su uso en pediatría y la forma de administración

  14. Isolation of mesenchymal stem cells from equine umbilical cord blood

    DEFF Research Database (Denmark)

    Koch, Thomas Gadegaard; Heerkens, Tammy; Thomsen, Preben Dybdahl;

    2007-01-01

    Background: There are no published studies on stem cells from equine cord blood although commercial storage of equine cord blood for future autologous stem cell transplantations is available. Mesenchymal stem cells (MSC) have been isolated from fresh umbilical cord blood of humans collected non-i...

  15. Isolation and culture of umbilical vein mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    D.T. Covas

    2003-09-01

    Full Text Available Bone marrow contains a population of stem cells that can support hematopoiesis and can differentiate into different cell lines including adipocytes, osteocytes, chondrocytes, myocytes, astrocytes, and tenocytes. These cells have been denoted mesenchymal stem cells. In the present study we isolated a cell population derived from the endothelium and subendothelium of the umbilical cord vein which possesses morphological, immunophenotypical and cell differentiation characteristics similar to those of mesenchymal stem cells isolated from bone marrow. The cells were isolated from three umbilical cords after treatment of the umbilical vein lumen with collagenase. The cell population isolated consisted of adherent cells with fibroblastoid morphology which, when properly stimulated, gave origin to adipocytes and osteocytes in culture. Immunophenotypically, this cell population was found to be positive for the CD29, CD13, CD44, CD49e, CD54, CD90 and HLA-class 1 markers and negative for CD45, CD14, glycophorin A, HLA-DR, CD51/61, CD106, and CD49d. The characteristics described are the same as those presented by bone marrow mesenchymal stem cells. Taken together, these findings indicate that the umbilical cord obtained from term deliveries is an important source of mesenchymal stem cells that could be used in cell therapy protocols.

  16. Hydrogen Vent Ground Umbilical Quick Disconnect - Flight Seal Advanced Development

    Science.gov (United States)

    Girard, Doug; Jankowski, Fred; Minich, Mark C.; Yu, Weiping

    2012-01-01

    This project is a team effort between NASA Engineering (NE) and Team QNA Engineering personnel to provide support for the Umbilical Systems Development project which is funded by Advanced Exploration Systems (AES) and 21st Century Launch Complex. Specifically, this project seeks to develop a new interface between the PPBE baselined Legacy SSP LH2 Vent Arm QD probe and SLS vent seal.

  17. Estimation of the total number of mast cells in the human umbilical cord. A methodological study

    DEFF Research Database (Denmark)

    Engberg Damsgaard, T M; Windelborg Nielsen, B; Sørensen, Flemming Brandt;

    1992-01-01

    The aim of the present study was to estimate the total number of mast cells in the human umbilical cord. Using 50 microns-thick paraffin sections, made from a systematic random sample of umbilical cord, the total number of mast cells per cord was estimated using a combination of the optical...... disector and fractionated sampling. The mast cell of the human umbilical cord was found in Wharton's jelly, most frequently in close proximity to the three blood vessels. No consistent pattern of variation in mast cell numbers from the fetal end of the umbilical cord towards the placenta was seen....... The total number of mast cells found in the umbilical cord was 5,200,000 (median), range 2,800,000-16,800,000 (n = 7), that is 156,000 mast cells per gram umbilical cord (median), range 48,000-267,000. Thus, the umbilical cord constitutes an adequate source of mast cells for further investigation...

  18. ANGIOPLASTIA PERCUTÁNEA CON STENT EN EL TRONCO PRINCIPAL DE LA ARTERIA CORONARIA IZQUIERDA / Percutaneous angioplasty with stent in the left main coronary artery

    Directory of Open Access Journals (Sweden)

    Javier Almeida Gómez

    2012-10-01

    Full Text Available ResumenIntroducción y objetivos: La afectación significativa del tronco común izquierdo, es la más letal de las presentaciones de la enfermedad arterial coronaria. El tratamiento de elección, es la cirugía de derivación aorto-coronaria. En varios estudios multicéntricos, se sugiere la posibilidad de tratar la enfermedad de tronco mediante el intervencionismo coronario percutáneo con implantación de prótesis endoluminal o stent. El objetivo de esta investigación fue caracterizar la angioplastia percutánea con stent en el tronco principal de la arteria coronaria izquierda. Método: Se realizó un estudio observacional, descriptivo y transversal en 21 pacientes con angioplastia percutánea con stent en el tronco principal de la arteria coronaria izquierda, realizadas en el laboratorio de Hemodinámica y Cardiología Intervencionista del Hospital "Hermanos Ameijeiras", entre enero 2010 y julio 2011. Resultados: No existió diferencia significativa en el sexo. Predominó el grupo de edad entre 50-64 años (47,6 % y el color de la piel blanca (76,19 %. El factor de riesgo cardiovascular más encontrado fue la HTA (85,71 %, seguido de dislipidemia (47,61 %. El diagnóstico más observado fue la angina de esfuerzo estable, 14 casos (66,66 %. La lesión en el cuerpo del tronco (12 pacientes, 57,1 %, fue la más encontrada, seguida de la ostial (8 casos. El tipo de stent más utilizado fue el liberador de fármacos (61,9 %, y solamente 4 pacientes presentaban troncos protegidos quirúrgicamente. Conclusiones: La mayor cantidad de casos fueron electivos, con predominio de los troncos no protegidos. El factor de riesgo coronario más encontrado fue la HTA. Se encontró asociación significativa entre la diabetes mellitus y la localización ostial de la lesión tratada. / AbstractIntroduction and Objectives: Significant impairment of the left main coronary artery is the most lethal presentation of coronary artery disease. The treatment of choice

  19. Utilidad de la derivación aVR en la identificación de la arteria responsable en el infarto inferior

    Directory of Open Access Journals (Sweden)

    Yanina B. Castillo Costa

    2006-01-01

    Full Text Available El ECG es el método más simple para el diagnóstico de infarto inferior (IAMinf; sin embargo, su utilidad disminuye para determinar el vaso responsable. Objetivos 1. Analizar la utilidad del desnivel del ST en aVR en la identificación de oclusión de las arterias coronaria derecha (CD o circunfleja (CX. 2. Evaluar la utilidad agregada a los criterios clásicos. Material y métodos Se incluyeron en el estudio 65 pacientes con IAMinf a quienes se les realizó una cinecoronariografía (CCG durante la internación. Se analizaron los criterios clásicos, así como el desnivel del ST en aVR: ?ST =?1 mm, ?ST =?1 mm o nivelado (isoST a 0,08 seg del punto J y se calcularon la sensibilidad (S, la especificidad (E, el valor predictivo positivo (VPP, el valor predictivo negativo (VPN y el likelihood ratio (LR. Se incluyó la derivación aVR en un análisis multivariado para determinar su valor agregado a los criterios clásicos. Resultados La CD fue responsable de la oclusión en 47 pacientes (72% y la CX en 18 (28%. Signos clásicos : CD : la relación del ?STD3/D2 =?1 se halló en 52 pacientes (91,5%; p = 0,001 e ?STD1-aVL =?1 mm en 34 (61%; p 1 en 13 pacientes (50%; p = 0,001 y ?STV5-V6 =?1 mm en 12 (44%; p < 0,001. Derivación aVR : CD : ?ST o isoST en 46 pacientes (81%; p < 0,001; CX : ?ST =?1 mm en 19 (56%; p < 0,001. En el análisis multivariado, el ?ST o isoST en aVR identificó a la CD (OR IC 95% 4,7 (1,1-19,8; p = 0,03, mientras que el ?ST aVR identificó a la CX. Se propone un algoritmo diagnóstico para CD que refleja el valor aditivo de aVR a la presencia de los signos clásicos: ?ST o isoST en aVR (VPP 94%; LR+: 2. Conclusión La derivación aVR es una herramienta útil para la identificación de la arteria responsable en el IAMinf, ya que brinda información diagnóstica adicional a los signos clásicos.

  20. Cuantificación del signo de la arteria cerebral media hiperdensa con TCMD Quantification of hyperdense middle cerebral artery sign by multidetector computed tomography (MDCT.

    Directory of Open Access Journals (Sweden)

    Francisco Meli

    2011-12-01

    Full Text Available Objetivos. Obtener una cuantificación absoluta y relativa de la densidad en el signo de la arteria cerebral media (ACM con el fin de lograr un valor objetivo para el diagnóstico temprano de isquemia cerebral aguda con TCMD. Materiales y Métodos. Se incluyeron 40 pacientes, 20 con sospecha de isquemia cerebral aguda (edad media 73,4 años y 20 pacientes controles (edad media 71,2 años, p=0,63, que se realizaron TC cerebral con un equipo de 64 filas de detectores. La cuantificación absoluta se realizó midiendo la densidad en UH en el segmento de la ACM visualmente de mayor densidad. También se midió la densidad en el mismo segmento de la ACM contralateral para calcular la diferencia entre ambas arterias (cuantificación relativa. Resultados. En pacientes casos, la densidad media de la ACM afectada (62,5 UH, IC 99%: 46,2-78,7 fue mayor que la de la ACM contralateral (39,3 UH, IC 99%: 33,3-45,3 (p=0,0004 y también fue mayor en comparación con la ACM en pacientes controles (44,7 UH, IC 99%: 37,4-52 (p=0,0045. En la cuantificación relativa, la diferencia media entre la densidad de la ACM afectada y la de ACM contralateral en los pacientes casos fue de 23,2 UH (IC 95%: 11,7-34,7, mientras que, en pacientes controles, la diferencia media entre la densidad de la ACM derecha y la ACM izquierda fue 5,2 UH (IC 95%: 2,4-8,4 (diferencia: 17,8 UH, p=0,0032, IC 95%: 6,8-28,8. Conclusión. Mostramos diferencias significativas (absolutas y relativas en la densidad de la ACM en pacientes con sospecha de isquemia cerebral aguda en comparación con sujetos normales.Purposes. To obtain absolute and relative quantification values of density in the middle cerebral artery (MCA sign, in order to obtain an objective value for an early diagnosis of acute ischemic stroke using MDCT. Material and Methods. Forty adult patients, 20 with suspected diagnosis of acute ischemic stroke (mean age: 73.4 years and 20 controls (mean age: 71.2 years, p=0.63, underwent brain

  1. Adaptación del algoritmo MARACAS para segmentación de la arteria carótida y cuantificación de estenosis en imágenes TAC

    Directory of Open Access Journals (Sweden)

    Doré Vincent

    2010-12-01

    Full Text Available En este artículo se describen las adaptaciones hechas al algoritmo MARACAS para segmentar y cuantificar estructuras vasculares en imágenes TAC de la arteria carótida. El algoritmo MARACAS, que está basado en un modelo elástico y en un análisis de los valores y vectores propios de la matriz de inercia, fue inicialmente diseñado para segmentar una sola arteria en imágenes ARM. Las modificaciones están principalmente enfocadas a tratar las especificidades de las imágenes TAC, así como la presencia de bifurcaciones. Los algoritmos implementados en esta nueva versión se clasifican en dos niveles. 1 Los procesamientos de bajo nivel (filtrado de ruido y de artificios direccionales, presegmentación y realce destinados a mejorar la calidad de la imagen y presegmentarla. Estas técnicas están basadas en información a priori sobre el ruido, los artificios y los intervalos típicos de niveles de gris del lumen, del fondo y de las calcificaciones. 2 Los procesamientos de alto nivel para extraer la línea central de la arteria, segmentar el lumen y cuantificar la estenosis. A este nivel, se aplican conocimientos a priori sobre la forma y anatomía de las estructuras vasculares. El método fue evaluado en 31 imágenes suministradas en el concurso “Carotid Lumen Segmentation and Stenosis Grading Grand Challenge” 2009. Los resultados obtenidos en la segmentación arrojaron un coeficiente de similitud de Dice promedio de 80.4% comparado con la segmentación de referencia, y el error promedio de la cuantificación de estenosis fue 14.4%.

  2. Alojamiento conjunto madre-hijo y lactancia humana exclusiva

    Directory of Open Access Journals (Sweden)

    FLORES-HUERTA SAMUEL

    1997-01-01

    Full Text Available Objetivo. Conocer la influencia del alojamiento conjunto (AC madre-hijo, en la frecuencia de lactancia humana exclusiva (LHE, desde el nacimiento hasta los cuatro meses de vida. Material y métodos. Estudio de cohortes no aleatorizado realizado en la clínica de lactancia del Hospital "Luis Castelazo Ayala", del Instituto Mexicano del Seguro Social, de enero de 1993 a octubre de 1994, en el que participaron 178 binomios madre-hijo (BMH sanos con gestación de término. El grupo con alojamiento conjunto (AC se integró con 90 BMH, y la madre recibió asesoría para lactar; 88 se atendieron en forma separada, sin asesoría para lactar. Se realizó análisis estadístico de los datos para apreciar frecuencia y asociaciones de las variables. Resultados. La alimentación se registró como LHE, fórmula o ambas. Los grupos con y sin AC se estratificaron por la forma de nacimiento, parto o cesárea. Con X² de Mantel-Haenszel y de rango logarítmico se aceptaron diferencias con p< 0.05. Durante el estudio la lactancia global fue semejante entre los grupos. En el primer mes la LHE fue mayor en el grupo con AC, 61 vs 42%, independientemente de la forma de nacimiento (p< 0.05. El AC fue la única variable que influyó para que se diera LHE. Conclusiones. El AC madre-hijo favorece la LHE en el primer mes posnacimiento.

  3. Tratamiento contra la rabia humana: un poco de su historia

    Directory of Open Access Journals (Sweden)

    Maria Cristina Schneider

    1994-12-01

    Full Text Available El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de veneno virus (en latín. En la Edad Media, cuando prevalecía un concepto mágico y religioso de la salud, el gran protector era San Humberto. Con el Renacimiento surgen nuevamente muchos experimentos y avances en el conocimiento de la enfermedad, que sentaron las bases para los importantes hallazgos en el futuro próximo. En esa época predominaba la teoría miasmática y del contagio. Pasteur fue un grande opositor de la espontaneidad de la rabia. A finales del siglo XIX, con los descubrimientos microbianos, Pasteur hizo la gran revolución científica en relación al tratamiento contra la rabia, que es la vacuna. Las vacunas pueden actualmente ser de tipo nervioso o no, variando también el numero de dosis recomendadas. Se han desarrollado muchos estudios sobre vacunas, siendo la más utilizada en América Latina del tipo Fuenzalida y Palacios, y la recomendada actualmente por la OMS es la de cultivo celular.

  4. Tratamiento contra la rabia humana: un poco de su historia

    Directory of Open Access Journals (Sweden)

    Schneider Maria Cristina

    1994-01-01

    Full Text Available El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de veneno virus (en latín. En la Edad Media, cuando prevalecía un concepto mágico y religioso de la salud, el gran protector era San Humberto. Con el Renacimiento surgen nuevamente muchos experimentos y avances en el conocimiento de la enfermedad, que sentaron las bases para los importantes hallazgos en el futuro próximo. En esa época predominaba la teoría miasmática y del contagio. Pasteur fue un grande opositor de la espontaneidad de la rabia. A finales del siglo XIX, con los descubrimientos microbianos, Pasteur hizo la gran revolución científica en relación al tratamiento contra la rabia, que es la vacuna. Las vacunas pueden actualmente ser de tipo nervioso o no, variando también el numero de dosis recomendadas. Se han desarrollado muchos estudios sobre vacunas, siendo la más utilizada en América Latina del tipo Fuenzalida y Palacios, y la recomendada actualmente por la OMS es la de cultivo celular.

  5. Aprendizaje máquina aplicado a la segmentación de imágenes ecográficas de la arteria carótida para la medida del grosor íntima-media

    OpenAIRE

    Menchón Lara, Rosa María

    2015-01-01

    [ESP] Las enfermedades cardiovasculares son la principal causa de mortalidad, morbilidad y discapacidad a nivel mundial. Gran parte de estas patologías derivan de la aterosclerosis, una enfermedad que afecta a las arterias de mediano y gran calibre provocando su endurecimiento y pérdida de elasticidad. La aterosclerosis se caracteriza por el engrosamiento de la capa más interna de las paredes arteriales debido al depósito de materia grasa, colesterol y otras sustancias. Por tanto, produce un ...

  6. Umbilical cord clamping. An analysis of a usual neonatological conduct.

    Science.gov (United States)

    Papagno, L

    1998-01-01

    Here we described a critical analysis of the neonatological procedure of early cord clamping, meaning this, within 40 seconds after birth. Fifty three cases are here analysed, in which this practice was not performed, but instead a late umbilical cord clamping was done after birth or after the cord had stopped beating. Variations in hematocrito values within 24 to 36 hours after birth were studied. A transitory polycithemia, with a maximum peak 12 hours post-delivery was observed. These values returned to normal levels between 24 and 36 hours after birth. K vitamin was not administered to any of the newborns. No pathology appeared related to this transitory polycithemia. In can be concluded that the late umbilical cord clamping represents no risk to the new-born and that the pathological phenomena described under these circumstances may be attributed to the increase in K vitamin dependent coagulation factors that are induced by the routinary administration of phitonadione to all normal newborns.

  7. Adiaspiromicose humana. Relato de um caso tratado com cetoconazol

    Directory of Open Access Journals (Sweden)

    Ricardo Luiz M. Martins

    1997-12-01

    Full Text Available É descrito um caso de adiaspiromicose humana, da forma pulmonar disseminada, no qual se empregou o cetoconazol. O paciente, oriundo de Goianésia, GO, referia tosse produtiva, dispnéia e emagrecimento. Doente há dois meses, já fizera uso do esquema tríplice tuberculostático, devido a um radiograma do tórax ter acusado lesões sugestivas de tuberculose miliar. Esse tratamento não surtiu o efeito esperado, pelo que foi ele submetido a uma biópsia pulmonar a céu aberto. A medida permitiu o reconhecimento da natureza fúngica da doença. Passou-se, então, ao emprego do cetoconazol, quando o processo já completara três meses de evolução. Dois meses depois, foi o paciente novamente visto, para controle do tratamento: todas as manifestações respiratórias haviam cessado e um novo radiograma mostrou regressão completa das alterações pulmonares. Apesar disso, é discutida a eficácia do cetoconazol contra C. parvum var crescens, tendo-se em conta o fato de o microrganismo não se reproduzir no hospedeiro.A case of human disseminated pulmonary adiaspiromycosis is reported. The patient, from Goianesia, GO, was admitted to the Brasilia University Hospital, in November 1992, with wet cough, dyspnea and weight loss3/4manifestations that had appeared two months before. Prior to admission, he had been treated for a suspected miliary tuberculosis, because a chest roentgenogram had shown a diffuse reticulonodular infiltrate in both lungs. This therapy brought no improvement to the patient status. An open chest biopsy was then performed, and the microscopic examination of the lung tissue revealed the fungal nature of the disease. Ketoconazole, 400mg/day, was started and the patient discharged from the hospital. He was seen again two months later: the respiratory manifestations had disappeared and a new chest roentgenogram showed complete resolution of the pulmonary lesions. The usefulness of ketoconazole is, however, questioned, since, as there

  8. Doppler ultrasound scan during normal gestation: umbilical circulation

    International Nuclear Information System (INIS)

    To determine normal umbilical circulation patterns by means of Doppler ultrasound scan in a healthy gestating population without risk factors and with normal perinatal results, and to evaluate any occurring modifications relative to gestational age by obtaining records kept during pregnancy. One hundred and sixteen pregnant women carrying a single fetus have been studied. These women had no risk factors, with both clinical and analytical controls, as well as ultrasound scans, all being normal. There were performed a total of 193 Doppler ultrasound scans between weeks 15 and 41 of gestation, with blood-flow analysis in the arteries and vein of the umbilical cord. The obtained information was correlated with parameters that evaluate fetal well-being (fetal monitoring and/or oxytocin test) and perinatal result (delivery type, birth weight, Apgar score). Statistical analysis was performed with the programs SPSS 6.0.1 for Windows and EPIINFO 6.0.4. With pulsed Doppler, the umbilical artery in all cases demonstrated a biphasic morphology with systolic and diastolic components and without retrograde blood flow. As the gestation period increased, there was observed a progressive decrease in resistance along with an increase in blood-flow velocity during the diastolic phase. The Doppler ultrasound scan is a non-invasive method that permits the hemodynamic study of umbilical blood circulation. A knowledge of normal blood-flow signal morphology, as well as of the normal values for Doppler indices in relation to gestational age would permit us to utilize this method in high-risk pregnancies. (Author) 30 refs

  9. Impact of Cytomegalovirus (CMV) Reactivation After Umbilical Cord Blood Transplantation

    OpenAIRE

    Beck, Jill C.; Wagner, John E.; DeFor, Todd E.; Brunstein, Claudio G.; Schleiss, Mark R.; Young, Jo-Anne; Weisdorf, Daniel H.; Cooley, Sarah; Miller, Jeffrey S.; Verneris, Michael R.

    2009-01-01

    This study investigated the impact of pre-transplant CMV serostatus and post-transplant CMV reactivation and disease on umbilical cord blood transplant (UCBT) outcomes. Between 1994 and 2007, 332 patients with hematologic malignancies underwent UCBT and 54% were CMV seropositive. Pre-transplant recipient CMV serostatus had no impact on acute or chronic GVHD, relapse, DFS or OS. There was a trend toward greater day 100 TRM in CMV seropositive recipients (p=0.07). CMV reactivation occurred in 5...

  10. Damage control apronectomy for necrotising fasciitis and strangulated umbilical hernia.

    LENUS (Irish Health Repository)

    Coyle, P

    2012-01-31

    We present a case of a 50-year-old morbidly obese woman who presented with a case of necrotizing fasciitis of the anterior abdominal wall due to a strangulated umbilical hernia. The case was managed through damage control surgery (DCS) with an initial surgery to stabilise the patient and a subsequent definitive operation and biological graft hernia repair. We emphasise the relevance of DCS principles in the management of severe abdominal sepsis.

  11. Isolation and culture of umbilical vein mesenchymal stem cells

    OpenAIRE

    D.T. Covas; J.L.C. Siufi; A.R.L. Silva; M. D. Orellana

    2003-01-01

    Bone marrow contains a population of stem cells that can support hematopoiesis and can differentiate into different cell lines including adipocytes, osteocytes, chondrocytes, myocytes, astrocytes, and tenocytes. These cells have been denoted mesenchymal stem cells. In the present study we isolated a cell population derived from the endothelium and subendothelium of the umbilical cord vein which possesses morphological, immunophenotypical and cell differentiation characteristics similar to tho...

  12. Anatomía del corazón y las arterias branquiales aferentes de las rayas (Chondrichthyes: Batoidea Anatomy of the heart and afferent branchial arteries of the rays (Chondrichthyes: Batoidea

    Directory of Open Access Journals (Sweden)

    Abraham Kobelkowsky

    2012-04-01

    Full Text Available Se selecionó el corazón y el sistema branquial aferente de Dasyatis sabina como patrón morfológico de los Batoidea. Se compararon las cámaras del corazón y la ramificación de la aorta ventral en las arterias branquiales aferentes con las correspondientes de especies representativas de otras familias de batoideos, tales como: Narcine brasiliensis (Narcinidae, Rhinobatos lentiginosus (Rhinobatidae, Raja texana (Rajidae, Urobatis jamaicensis (Urolophidae, Gymnura micrura (Gymnuridae y Myliobatis sp. (Myliobatidae. El análisis comparativo permitió reconocer como carácter más notable, la ausencia de las arterias innominadas posteriores en los Myliobatiformes, con excepción de Gymnuridae. Asimismo, permitió observar la amplia similitud entre Rhinobatidae y Rajidae, y entre Urotrygonidae y Dasyatidae.The heart and the afferent branchial system of the ray, Dasyatis sabina was selected as a morphologic pattern of the Batoidea. A comparison of the heart and the ramification of the ventral aorta into the branchial afferent arteries was made with the corresponding in representative species of other families of Batoidea, such as: Narcine brasiliensis (Narcinidae, Rhinobatos lentiginosus (Rhinobatidae, Raja texana (Rajidae, Urobatis jamaicensis (Urolophidae, Gymnura micrura (Gymnuridae, and Myliobatis sp. (Myliobatidae. The comparative analysis allows recognizing as the most notably character, the absence of the posterior innominates arteries in the Myliobatiformes, with the exception of Gymnuridae. A high similitude between Rhinobatidae and Rajidae, and Urolophidae and Dasyatidae was recognized.

  13. Exploración de las arterias coronarias de pacientes con síndrome de Tako-Tsubo con tomografía multislice: lesiones e inferencias fisiopatológicas

    Directory of Open Access Journals (Sweden)

    Omar Santaera

    2009-01-01

    Full Text Available Existen numerosos casos comunicados sobre la disfunción ventricular izquierda reversibleprecipitada por estrés emocional, pero su mecanismo no se conoce. En esta presentación sedescribe la evaluación de dos pacientes que consultaron con un cuadro clínico típico desíndrome de Tako-Tsubo, dolor precordial luego de un estrés emocional, disfunción ventricularizquierda transitoria y arterias coronarias angiográficamente normales. Con el objetivo deprofundizar el conocimiento de las arterias coronarias y la fisiopatología de esta enfermedad,a ambas se les realizó una tomografía multislice, en la que se evidenciaron lesionescoronarias similares a las halladas en accidentes de placa responsables de síndromescoronarios agudos. Si bien estos hallazgos deben completarse con estudios posteriores conun número mayor de pacientes, sugieren que al menos un subgrupo de pacientes con síndromede Tako-Tsubo tiene un sustrato fisiopatológico similar a los síndromes coronariosagudos.REV ARGENT CARDIOL 2009;77:227-230.

  14. Associations between intrapartum death and piglet, placental, and umbilical characteristics.

    Science.gov (United States)

    Rootwelt, V; Reksen, O; Farstad, W; Framstad, T

    2012-12-01

    Intrapartum death in multiparous gestations in sows (Sus scrofa) is often caused by hypoxia. There is little information in the literature on the assessment of the placenta in relation to intrapartum death in piglets. The aim of this study was to evaluate the impact of the placental area and weight upon piglet birth characteristics and intrapartum death. Litters from 26 Landrace-Yorkshire sows were monitored during farrowing and the status of each piglet was recorded, including blood parameters of piglets and their umbilical veins. Of 413 piglets born, 6.5% were stillborn. Blood concentrations of glucose, lactate, and CO(2) partial pressure were increased in the stillborn piglets (P piglets, whereas pH and base excess were decreased (P piglets born dead vs. live (P piglets born dead was not different from live-born piglets (P = 0.631), whereas mean body mass index was reduced (P piglets were not different from live-born piglets (P = 0.662 and P = 0.253, respectively). Blood concentrations of lactate, hemoglobin, and hematocrit recorded in all piglets pooled were associated with placental area (P 0.2). Piglet BW was positively correlated with placental area and placental weight (P piglet birth weight, but not with the probability of being born dead. Placental area was a better predictor of piglet vitality than placental weight. Because umbilical cord rupture and prolonged birth time were associated with being born dead, umbilical cord rupture and placental detachment seem to be probable causes of intrapartum death.

  15. Good practices in collecting umbilical cord and placental blood 1

    Science.gov (United States)

    Lopes, Lauren Auer; Bernardino, Elizabeth; Crozeta, Karla; Guimarães, Paulo Ricardo Bittencourt

    2016-01-01

    Abstract Objective: to identify the factors related to the quality of umbilical cord and placental blood specimens, and define best practices for their collection in a government bank of umbilical cord and placental blood. Method: this was a descriptive study, quantitative approach, performed at a government umbilical cord and placental blood bank, in two steps: 1) verification of the obstetric, neonatal and operational factors, using a specific tool for gathering data as non-participant observers; 2) definition of best practices by grouping non-conformities observed before, during and after blood collection. The data was analyzed using descriptive statistics and the following statistical software: Statistica(r) and R(r). Results: while there was a correlation with obstetrical and neonatal factors, there was a larger correlation with operational factors, resulting in the need to adjust the professional practices of the nursing staff and obstetrical team involved in collecting this type of blood. Based on these non-conformities we defined best practices for nurses before, during and after blood collection. Conclusion: the best practices defined in this study are an important management tool for the work of nurses in obtaining blood specimens of high cell quality. PMID:27556876

  16. The Development and Implementation of the Kennedy Space Center Umbilical Clearance Tool

    Science.gov (United States)

    Chesnutt, David

    2016-01-01

    In preparation for NASAs upcoming Space Launch System program, the Kennedy Space Center is currently developing subsystems to provide fuel, purges and communications to the flight vehicle, known as umbilicals. It is vital to the crew and mission that these umbilicals release at T-0 without re-contacting the vehicle as it is accelerating from the launch pad. To help ensure this requirement is met by the program, a methodology of evaluating the moving bodies was developed and implemented into a tool using MATLAB. The tool, known as the KSC Umbilical Clearance Tool, takes a given elevation of interest and an umbilical retract profile within the plane to evaluate the clearance between the umbilical arm and thousands of independent flight vehicle drift profiles from a Monte Carlo analysis. The presentation will delve into the challenges associated with developing and implementing the tool framed in the context of evaluating the clearance for one of the SLS umbilicals.

  17. LA CONSULTORÍA DE GESTIÓN HUMANA EN EMPRESAS MEDIANAS

    Directory of Open Access Journals (Sweden)

    ESTEBAN LÓPEZ ZAPATA

    2010-01-01

    Full Text Available El artículo es resultado de una investigación que busca describir el mercado de la consultoría de gestión humana para empresas medianas de Medellín. Se identifi can el concepto y las características de la consultoría gerencial y se plantea su pertinencia para cada proceso de gestión humana. Con una muestra de 57 empresas medianas y 19 empresas consultoras, se analiza el comportamiento de la demanda y la oferta en el contexto local. Se identifi can los atributos de las empresas demandantes y sus dependencias de gestión humana, la composición de las empresas consultoras, las necesidades y ofertas de consultoría actuales y futuras, el proceso de compra y las difi cultades frecuentes de los proyectos de consultoría.

  18. Umbilical Cord Blood: Counselling, Collection, and Banking.

    Science.gov (United States)

    Armson, B Anthony; Allan, David S; Casper, Robert F

    2015-09-01

    Objectif : Analyser les données probantes actuelles sur le counseling, le prélèvement et la mise en banque, en ce qui a trait au sang de cordon ombilical, et fournir des lignes directrices aux professionnels canadiens de la santé en ce qui concerne la sensibilisation des patientes, le consentement éclairé, les aspects techniques et les options pour la mise en banque de sang de cordon au Canada. Options : Prélèvement sélectif ou systématique et mise en banque du sang de cordon ombilical, en vue de futures greffes autologues (chez le patient même) ou allogéniques (lien de parenté ou non) de cellules souches visant la prise en charge de troubles malins et bénins chez les enfants et les adultes. Le sang de cordon peut être prélevé au moyen de techniques in utero ou ex utero. Issues : Counseling, prélèvement et mise en banque en ce qui a trait au sang de cordon ombilical, formation des professionnels de la santé, indications du prélèvement de sang de cordon, risques et avantages à court et à long terme, morbidité maternelle et périnatale, satisfaction parentale et coûts de santé. Résultats : La littérature publiée a été récupérée par l’intermédiaire de recherches menées dans Medline et PubMed à partir de septembre 2013, au moyen d’un vocabulaire contrôlé (p. ex. « fetal blood », « pregnancy », « transplantation », « ethics ») et de mots clés (p. ex. « umbilical cord blood », « banking », « collection », « pregnancy », « transplantation », « ethics », « public », « private ») MeSH appropriés. Les résultats ont été restreints aux analyses systématiques, aux études observationnelles et aux essais comparatifs randomisés / essais cliniques comparatifs. Aucune limite n’a été imposée en matière de date, mais les résultats ont été limités aux articles publiés en anglais ou en français. Les recherches ont été mises à jour de façon régulière et int

  19. Umbilical intra-abdominal vein varix: a case report and review of the literature.

    Science.gov (United States)

    Virdis, G; Gulotta, A; Cherchi, C; Spanedda, G; Olzai, M G; Ambrosini, G; Dessole, S; Capobianco, G

    2016-01-01

    Fetal umbilical intra-abdominal vein varix (FIUV) is a rare congenital malformation characterized by focal dilatation of the umbilical vein. The authors report a case of pregnant woman at 32 weeks of gestation with a fetus affected by dilatation of an intra-abdominal portion of the umbilical vein. They performed continuous ultrasound and cardiotocographic monitoring, from admission to the delivery. They describe the case and perform a review of the literature. PMID:27132426

  20. Sonographic Measurement of the Umbilical Cord and Its Vessels and Their Relation with Fetal Anthropometric Measurements

    OpenAIRE

    Rostamzadeh; Kalantari; Shahriari; Shakiba

    2015-01-01

    Background It has been established that presence of lean umbilical cord with reduced Wharton’s jelly in sonographic scans is a fetal marker for risk of small for gestational age at birth. With improvement of ultrasound techniques, more studies have been investigating the alterations of the umbilical cord on pregnancy outcomes. Objectives To determine the reference ranges of the umbilical cord area during pregnancy and to find out ...

  1. Karyotype stability of human umbilical cord-derived mesenchymal stem cells during in vitro culture

    OpenAIRE

    RUAN, ZHONG-BAO; Zhu, Li; YIN, YI-GANG; Chen, Ge-cai

    2014-01-01

    The aim of this study was to investigate whether the chromosomes of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) change following in vitro culture for several generations. In the present study, umbilical cords from two healthy infants following cesarean delivery were collected aseptically and hUCMSCs were isolated by digestion with collagenase and trypsin, and then cultured in vitro. hUCMSCs with fibroblastic morphology were presented from the human umbilical cord tissue afte...

  2. Isolation, culture and characterization of postnatal human umbilical vein-derived mesenchymal stem cells

    OpenAIRE

    Mehdi Kadivar; Shohreh Khatami; Yousef Mortazavi; Masoud Soleimani; Mohammad Taghikhani; Mohammad Ali Shokrgozar

    2005-01-01

    On the basis of reports that mesenchymal stem cells (MSCs) can be isolated from the placenta/umbilical cord stroma, the present study was undertaken to isolate and characterize MSCs from the human umbilical cord veins. In this investigation, a cell population was isolated which was derived from the endothelium/subendothelium layers of 20 umbilical cord veins obtained from term deliveries using a solution of 0.1% collagenase type IV. Results suggest that these cells possess morphological, immu...

  3. Aspectos médico legales de la clonación humana

    OpenAIRE

    Marco Mairena Navarro; Ramón Zamora Montes

    2002-01-01

    Las técnicas de reproducción asistida, y entre ellas la clonación humana, suscitan interrogantes éticas. Su empleo promete beneficios para la humanidad y, específicamente para parejas infértiles la satisfacción de ser madres y padres. En este artículo se debaten las regulaciones y las implicaciones jurídicas de dicha actividad, actualizándonos en el acontecer mundial y nacional del tema. Se argumenta que la clonación humana ya es una realidad y como si esta técnica se regula promueve la vida ...

  4. Actitudes del personal sanitario ante la clonación humana

    OpenAIRE

    Lupiani Giménez, María Mercedes

    2006-01-01

    Las Ciencias Biosanitarias -como la Física en su día- se han convertido en TECNOLOGÍA, adquiriendo el poder de manipular la estructura de la vida y producirla artificialmente por CLONACIÓN. ¡ Presumiblemente incluso la humana!. Pero en este campo, como sucede con las Tecnologías poderosas, existen FUERTES CONTRADICCIONES, habiéndose abierto un DEBATE SOCIAL áspero y apasionante que ha alcanzado a todos los tejidos sociales, incluido el político. Sin duda, la Clonación Humana, junto con la Ing...

  5. LA CONSULTORÍA DE GESTIÓN HUMANA EN EMPRESAS MEDIANAS

    OpenAIRE

    ESTEBAN LÓPEZ ZAPATA; CLAUDIA INÉS SEPÚLVEDA RIVILLAS; HENRY ANTONIO ARENAS CARDONA

    2010-01-01

    El artículo es resultado de una investigación que busca describir el mercado de la consultoría de gestión humana para empresas medianas de Medellín. Se identifi can el concepto y las características de la consultoría gerencial y se plantea su pertinencia para cada proceso de gestión humana. Con una muestra de 57 empresas medianas y 19 empresas consultoras, se analiza el comportamiento de la demanda y la oferta en el contexto local. Se identifi can los atributos de las empresas demandantes y s...

  6. MUROS ABSURDOS E CONDIÇÃO HUMANA NA OBRA DE ALBERT CAMUS

    Directory of Open Access Journals (Sweden)

    Patrícia Oliveira Machado

    2015-04-01

    Full Text Available Albert Camus descreve a condição humana como sendo contingente, frágil e absurda, para isso ele utiliza a noção de “muros absurdos”, que são situações que enfrentamos e contra as quais não podemos escapar. Se a princípio, a morte, a velhice, a desumanidade parecem experiências banais, no pensamento camusiano, elas se revelam como possibilidade de tomada de consciência do absurdo de nossa condição. Palavras-chave: absurdo; condição humana; consciência.

  7. Umbilical endometriosis mimicking as papilloma to general surgeons: A case report

    Directory of Open Access Journals (Sweden)

    A Singh

    2012-05-01

    Full Text Available IntroductionCutaneous or umbilical endometriosis is a rare entity that isoften overlooked because of chronic abdominal pain. Wepresent a case of umbilical hernia that presented to thegeneral surgeons due to chronic abdominal pain and nodulein the umbilicus, which was clinically diagnosed as umbilicalpapilloma.Case presentationA 48-year old multiparous Caucasian woman presented withpainful nodule in the umbilicus for two and half years. Thenodule was excised and the histopathological diagnosis wasumbilicus endometriosis.ConclusionUmbilical endometriosis is a very rare disease but should beconsidered as a differential diagnosis in women presentingwith umbilical swelling.

  8. Arteria iliaca interna transplantation to repair arteria iliacaexterna

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@CASE REPORT A 20-year-old man was admitted for blunt trauma to left lower abdomen and dysfunction of left lower limb for 8 h. Physical examination: skin contusion for 5 cm in diameter at the left iliac fossa, accompanied with subcutaneous extravasated blood, tenderness and rebound tenderness of left lower quadrant, no abnormality of rectum palpated by digital examination. The left lower limb was pale, paresthesia, paralysis and low skin temperature, but no pitting edema. The pulsation of the left femoral artery and dorsalis pedis artery could not be palpated. Color Doppler imaging showed no flow in lumen of the upper portion of the left external iliac artery for 5-6 cm in length. The diagnosis,was traumatic arterial occlusion of the left external iliac artery. Laparotomy was performed. Haematoma in left lower abdominal wall and retroperitoneum, partial sever of external and internal oblique muscle were found. Dissection of the common iliac artery, external and internal iliac artery showed normal pulsation of

  9. Sonographic Measurement of the Umbilical Cord and Its Vessels and Their Relation with Fetal Anthropometric Measurements

    Directory of Open Access Journals (Sweden)

    Rostamzadeh

    2015-07-01

    Full Text Available Background It has been established that presence of lean umbilical cord with reduced Wharton’s jelly in sonographic scans is a fetal marker for risk of small for gestational age at birth. With improvement of ultrasound techniques, more studies have been investigating the alterations of the umbilical cord on pregnancy outcomes. Objectives To determine the reference ranges of the umbilical cord area during pregnancy and to find out the association between umbilical cord morphometry and fetal anthropometric measurements. Patients and Methods A cross sectional study was carried out on a study population of 278 low-risk pregnant women between 15 and 41 weeks of gestational age. Fetal anthropometric measurements including biparietal diameter, abdominal circumference, and femur length were calculated. The measurements of the cross-sectional area (CSA and circumference of the umbilical cord, vein and arteries were done on an adjacent plane to the insertion of umbilical cord into the fetus’s abdomen. The mean and standard deviation of the CSA of the umbilical cord and the 5th, 10th, 50th, 90th, 95th percentiles of it were calculated for each gestational age. Pearson correlation coefficient was used to assess the correlation between the measures of the cord and fetal anthropometric measurements. Polynomial regression analysis was performed for curves. Results The values of the CSA of the umbilical cord, umbilical vein and Wharton’s jelly (WJ increase consistently until 30 weeks of gestation, after which they reach a plateau. There was a significant correlation between anthropometric measurements and umbilical cord measurements especially with the CSA of the umbilical cord, umbilical vein and WJ. The regression equation for the umbilical cord CSA according to gestational age up to 30 weeks was y = -0.2159 x2 + 23.828x-325.59 (R2 = 0.6334 and for the WJ area according to gestational age up to 30 weeks, it was y = -0.2124 x 2 +17.613x-221.66 (R2 = 0

  10. La comunicación humana : principios básicos

    OpenAIRE

    Viana Orta, María Isabel

    2012-01-01

    Principios básicos de la comunicación humana. Comunicación oral, no verbal y persuasiva. El material forma parte de cursos de formación en temas de resolución de conflictos, comunicación y mediación.

  11. Humana looks to ISO registration to address quality improvement and customer satisfaction.

    Science.gov (United States)

    2003-01-01

    Seeking new ways to improve standardization of clinical operations and customer focus, Louisville, KY-based Humana, Inc. announced in November that it has become the first healthcare company to be registered in the U.S. under ISO 9001:2000, a quality management standard published by the International Organization for Standardization (ISO).

  12. File list: ALL.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells hg19 All antigens Cardiovascular Prima...hu-u/hg19/assembled/ALL.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells.bed ...

  13. File list: ALL.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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  15. File list: ALL.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. Gerente de projetos: habilidades humanas e comportamentais / Project manager: human and behaviours skills

    Directory of Open Access Journals (Sweden)

    Edson Coutinho da Silva

    2016-04-01

    Full Text Available Um gerente de projetos deve priorizar as habilidades humanas e comportamentais do que as habilidades técnicas para a obtenção de êxito de projetos; uma vez que são as pessoas e a equipe que compõem um projeto. O artigo tem o propósito de descrever as habilidades humanas requeridas para um gestor conduzir a implementação de um projeto em uma organização, na busca de mitigar os conflitos com os stakeholders. Foi elaborada uma pesquisa descritiva alicerçadas por técnicas como a pesquisa-ação e estudo de caso. Os dados foram obtidos por meio da experiência de um dos pesquisadores deste artigo no projeto e por meio de seis entrevistas com membros da equipe. Os pesquisadores estabeleceram cinco habilidades humanas e comportamentais que são requeridas aos gerentes: liderança, comunicação, gestão de mudança, motivação e gestão de conflito; e as usou para fins de análise e discussão dos resultados. Concluiu-se, pelo projeto de implementação do ERP pesquisado neste estudo, que esta organização considerou prioritariamente as habilidades técnicas do que as humanas ao selecionar alguns de seus gestores; e foi exatamente a ausência de repertório de habilidades humanas que comprometeu o gerenciamento do projeto.

  17. Nationwide prospective study on readmission after umbilical or epigastric hernia repair

    DEFF Research Database (Denmark)

    Helgstrand, F; Jørgensen, L N; Rosenberg, J;

    2013-01-01

    The primary aim of the present study was to investigate risk factors for readmission after elective umbilical and epigastric hernia repair and secondarily to evaluate causes for readmission.......The primary aim of the present study was to investigate risk factors for readmission after elective umbilical and epigastric hernia repair and secondarily to evaluate causes for readmission....

  18. Chondrogenic potential of mesenchymal stromal cells derived from equine bone marrow and umbilical cord blood

    DEFF Research Database (Denmark)

    Berg, Lise Charlotte; Koch, Thomas Gadegaard; Heerkens, T.;

    2009-01-01

    including bone marrow and umbilical cord blood. The objective of this study was to provide an in vitro comparison of the chondrogenic potential in MSC derived from adult bone marrow (BM-MSC) and umbilical cord blood (CB-MSC). Results: MSC from both sources produced tissue with cartilage-like morphology...

  19. Umbilical cord blood lactate: a valuable tool in the assessment of fetal metabolic acidosis

    DEFF Research Database (Denmark)

    Gjerris, Anne Cathrine Roslev; Staer-Jensen, Jette; Jørgensen, Jan Stener;

    2008-01-01

    The aim of the present study was (1) to evaluate the relationship between umbilical cord arterial blood lactate and pH, standard base excess (SBE), and actual base excess (ABE) at delivery and (2) to suggest a cut-off level of umbilical cord arterial blood lactate in predicting fetal asphyxia usi...

  20. Umbilical cord blood lactate: a valuable tool in the assessment of fetal metabolic acidosis

    DEFF Research Database (Denmark)

    Gjerris, A.C.; Staer-Jensen, J.; Jorgensen, J.S.;

    2008-01-01

    OBJECTIVE: The aim of the present study was (1) to evaluate the relationship between umbilical cord arterial blood lactate and pH, standard base excess (SBE), and actual base excess (ABE) at delivery and (2) to suggest a cut-off level of umbilical cord arterial blood lactate in predicting fetal a...

  1. Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury

    DEFF Research Database (Denmark)

    Grandjean, Philippe; Budtz-Jørgensen, Esben; Jørgensen, Poul J.;

    2005-01-01

    biomarker, exposure assessment, food contamination, hair analysis, mercury/analysis, methylmercury compounds/analysis, organomercury compounds/blood, pregnancy, prenatal exposure delayed effects, preschool child, seafood, umbilical cord.......biomarker, exposure assessment, food contamination, hair analysis, mercury/analysis, methylmercury compounds/analysis, organomercury compounds/blood, pregnancy, prenatal exposure delayed effects, preschool child, seafood, umbilical cord....

  2. File list: InP.Bld.50.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  3. File list: NoD.Bld.50.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

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  4. File list: InP.Bld.20.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

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  5. File list: NoD.Bld.05.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

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  6. File list: InP.Bld.05.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

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  7. File list: NoD.Bld.20.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

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  8. File list: NoD.Bld.10.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  9. File list: InP.Bld.10.AllAg.Umbilical_cord_blood [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  10. File list: NoD.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  11. File list: DNS.CDV.20.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  12. File list: Pol.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  13. File list: DNS.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  14. File list: DNS.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  15. File list: InP.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. File list: NoD.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  17. File list: NoD.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  18. File list: InP.CDV.20.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  19. File list: InP.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Pol.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells hg19 RNA polymerase Cardiovascular Prima...ry umbilical vein endothelial cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.CDV.50.AllAg.Primary_umbilical_vein_endothelial_cells.bed ...

  1. File list: InP.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells hg19 Input control Cardiovascular Prima...ry umbilical vein endothelial cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.CDV.05.AllAg.Primary_umbilical_vein_endothelial_cells.bed ...

  2. File list: DNS.CDV.10.AllAg.Primary_umbilical_vein_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  3. File list: InP.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  4. File list: His.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  5. File list: DNS.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 DNase-seq Cardi...ovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  6. File list: NoD.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  7. File list: DNS.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 DNase-seq Cardi...ovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  8. File list: Pol.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 RNA polymerase ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/Pol.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  9. File list: Pol.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 RNA polymerase ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/Pol.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  10. File list: Pol.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 RNA polymerase ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/Pol.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  11. File list: Unc.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  12. File list: ALL.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  13. File list: Unc.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  14. File list: NoD.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  15. File list: ALL.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  16. File list: Oth.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 TFs and others ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/Oth.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  17. File list: Oth.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  18. File list: His.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  19. File list: NoD.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  20. File list: Oth.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 TFs and others ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/Oth.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  1. File list: His.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  2. File list: DNS.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  3. File list: ALL.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  4. File list: Pol.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  5. File list: InP.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  6. File list: Unc.CDV.50.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  7. File list: Unc.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  8. File list: ALL.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  9. File list: InP.CDV.05.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  10. File list: Oth.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  11. File list: NoD.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 No description ...Cardiovascular Umbilical cord-derived mesenchymal stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19.../assembled/NoD.CDV.10.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  12. File list: InP.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells hg19 Input control C...ardiovascular Umbilical cord-derived mesenchymal stem cells SRX831247,SRX831246 http://dbarchive.bioscienced...bc.jp/kyushu-u/hg19/assembled/InP.CDV.20.AllAg.Umbilical_cord-derived_mesenchymal_stem_cells.bed ...

  13. Ultrasound Assessment of Umbilical Cord Morphology in the First Trimester: A Feasibility Study

    DEFF Research Database (Denmark)

    Narayan, Rajit; Saaid, Rahmah; Pedersen, Lars Henning;

    2015-01-01

    Objective: The aim of this study was to determine whether morphology and measurement of the umbilical cord could be accurately assessed at the time of the 11- to 13+6-week scan. Methods: We conducted a prospective study of 100 consecutive women with singleton pregnancies at 11-13+6 weeks' gestati...... who were seen for routine aneuploidy screening. Transabdominal ultrasound scans were performed, and the distance between two adjacent coils of the umbilical artery was measured in a free loop of umbilical cord. The antenatal umbilical coiling index (aUCI) was calculated as the inverse...... velocity also increased with gestation. Interobserver consistency in the objective measurement of the aUCI was poor (kappa 0.146). However, the Sepulveda classification system was found to be applicable and reproducible at this period of gestation (kappa 0.601). Conclusions: Umbilical cord morphology can...

  14. Umbilical cord clamping. An analysis of a usual neonatological conduct.

    Science.gov (United States)

    Papagno, L

    1998-01-01

    Here we described a critical analysis of the neonatological procedure of early cord clamping, meaning this, within 40 seconds after birth. Fifty three cases are here analysed, in which this practice was not performed, but instead a late umbilical cord clamping was done after birth or after the cord had stopped beating. Variations in hematocrito values within 24 to 36 hours after birth were studied. A transitory polycithemia, with a maximum peak 12 hours post-delivery was observed. These values returned to normal levels between 24 and 36 hours after birth. K vitamin was not administered to any of the newborns. No pathology appeared related to this transitory polycithemia. In can be concluded that the late umbilical cord clamping represents no risk to the new-born and that the pathological phenomena described under these circumstances may be attributed to the increase in K vitamin dependent coagulation factors that are induced by the routinary administration of phitonadione to all normal newborns. PMID:9914812

  15. Optoacoustic measurements of human placenta and umbilical blood oxygenation

    Science.gov (United States)

    Nanovskaya, T. N.; Petrov, I. Y.; Petrov, Y.; Patrikeeva, S. L.; Ahmed, M. S.; Hankins, G. D. V.; Prough, D. S.; Esenaliev, R. O.

    2016-03-01

    Adequate oxygenation is essential for normal embryogenesis and fetal growth. Perturbations in the intrauterine oxidative environment during pregnancy are associated with several pathophysiological disorders such as pregnancy loss, preeclampsia, and intrauterine growth restriction. We proposed to use optoacoustic technology for monitoring placental and fetal umbilical blood oxygenation. In this work, we studied optoacoustic monitoring of oxygenation in placenta and umbilical cord blood ex vivo using technique of placenta perfusion. We used a medical grade, nearinfrared, tunable, optoacoustic system developed and built for oxygenation monitoring in blood vessels and in tissues. First, we calibrated the system for cord blood oxygenation measurements by using a CO-Oximeter (gold standard). Then we performed validation in cord blood circulating through the catheters localized on the fetal side of an isolated placental lobule. Finally, the oxygenation measurements were performed in the perfused placental tissue. To increase or decrease blood oxygenation, we used infusion of a gas mixture of 95% O2 + 5% CO2 and 95% N2 + 5% CO2, respectively. In placental tissue, up to four cycles of changes in oxygenation were performed. The optoacoustically measured oxygenation in circulating cord blood and in placental lobule closely correlated with the actual oxygenation data measured by CO-Oximeter. We plan to further test the placental and cord blood oxygenation monitoring with optoacoustics in animal and clinical studies.

  16. Efeito protetor da lactoferrina humana no trato gastrintestinal Efecto protector de la lactoferrina humana en el sistema gastrointestinal Protective effect of human lactoferrin in the gastrointestinal tract

    OpenAIRE

    Valterlinda Alves de O. Queiroz; Assis, Ana Marlúcia O; Hugo da Costa R. Júnior

    2013-01-01

    OBJETIVO: Descrever os mecanismos de ação da lactoferrina humana na proteção de morbidades gastrintestinais. FONTES DE DADOS: Revisão não sistemática da literatura utilizando como estratégia de busca pesquisa bibliográfica em bases de dados, as quais incluíram SciELO, Lilacs e MedLine entre 1990 e 2011. Os descritores utilizados foram: lactoferrina, leite materno/humano, gastrintestinal e imunidade, nos idiomas português e inglês. SÍNTESE DOS DADOS: A lactoferrina é a segunda proteína predomi...

  17. Deformation of the left and right ventricular longitudinal myocardium in fetuses with umbilical cord around neck

    Institute of Scientific and Technical Information of China (English)

    ZUO Dong-mei; WANG Chao-hong; WANG Yue-heng

    2012-01-01

    Background Umbilical cord around neck,a common obstetric complication,affects fetal hemodynamics.Does it influence fetal cardiac functions? The purpose of this study was to investigate the left and right ventricular systolic and diastolic functions of fetuses with umbilical cord around neck in the third trimester by applying velocity vector imaging (VVI).Methods Thirty-five cases of fetuses with umbilical cord around neck whose gestational ages from 35 to 40 weeks were selected,including 20 cases of umbilical artery ratio of the highest systolic velocity (S) to the lowest diastolic velocity (D) (S/D) <3.0 and 15 cases of umbilical artery S/D ≥3.0,while 20 cases of normal fetuses of 35-40 gestational weeks were selected as the control group.The changes in longitudinal velocity,strain,and strain rate of fetal left and right ventricle in systole and diastole in two groups,and the changes in fetal cardiac function under the situation of umbilical cord around neck were analyzed.Results Longitudinal strain and strain rate overall of fetal left and right ventricle in systole and diastole were less in fetuses with umbilical artery S/D ≥3.0 and umbilical cord around neck than those in fetuses with umbilical artery S/D <3.0and those in control group (P <0.05); there was no significant difference (P >0.05) in longitudinal strain and strain rate overall of fetal left and right ventricle in systole and diastole between fetuses with umbilical artery S/D <3.0 and those in control group.Conclusions Left and right ventricular systolic and diastolic dysfunction was detected in fetuses with umbilical cord around neck and umbilical artery S/D ≥3.0.WI could sensitively respond to cardiac function changes in fetuses with umbilical cord around neck,which provides another valuable method in the evaluation of fetal cardiac function.

  18. Efeito protetor da lactoferrina humana no trato gastrintestinal Efecto protector de la lactoferrina humana en el sistema gastrointestinal Protective effect of human lactoferrin in the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Valterlinda Alves de O. Queiroz

    2013-03-01

    Full Text Available OBJETIVO: Descrever os mecanismos de ação da lactoferrina humana na proteção de morbidades gastrintestinais. FONTES DE DADOS: Revisão não sistemática da literatura utilizando como estratégia de busca pesquisa bibliográfica em bases de dados, as quais incluíram SciELO, Lilacs e MedLine entre 1990 e 2011. Os descritores utilizados foram: lactoferrina, leite materno/humano, gastrintestinal e imunidade, nos idiomas português e inglês. SÍNTESE DOS DADOS: A lactoferrina é a segunda proteína predominante no leite humano, com concentrações mais elevadas no colostro (5,0 a 6,7mg/mL em relação ao leite maduro (0,2 a 2,6mg/mL. Em contraste, o leite de vaca contém teores inferiores, 0,83mg/mL no colostro e 0,09mg/mL no leite maduro. A lactoferrina desempenha diversas funções fisiológicas na proteção do trato gastrintestinal. A atividade antimicrobiana está relacionada à capacidade de sequestrar ferro dos fluidos biológicos e/ou de desestruturar a membrana de micro-organismos. A lactoferrina possui também a capacidade de estimular a proliferação celular. A ação anti-inflamatória desempenhada pela lactoferrina está associada à capacidade de penetrar no núcleo do leucócito e bloquear a transcrição do fator nuclear Kappa B. Diante da importância da lactoferrina na prevenção de doenças infecciosas em crianças aleitadas ao peito, a indústria vem, por meio da engenharia genética, desenvolvendo tecnologias para expressar esta proteína recombinante humana em plantas e animais, na tentativa de adequar a composição das fórmulas infantis àquela do leite humano. CONCLUSÕES: A lactoferrina humana é um peptídeo com potencial para prevenir morbidades, especialmente às gastrintestinais. Evidências científicas dos efeitos protetores da lactoferrina humana fortalecem ainda mais a recomendação para prática do aleitamento materno.OBJETIVO: Describir los mecanismos de acción de la lactoferrina humana en la protecci

  19. Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice.

    Directory of Open Access Journals (Sweden)

    Hongshan Liu

    Full Text Available BACKGROUND: Keratoplasty is the most effective treatment for corneal blindness, but suboptimal medical conditions and lack of qualified medical personnel and donated cornea often prevent the performance of corneal transplantation in developing countries. Our study aims to develop alternative treatment regimens for congenital corneal diseases of genetic mutation. METHODOLOGY/PRINCIPAL FINDINGS: Human mesenchymal stem cells isolated from neonatal umbilical cords were transplanted to treat thin and cloudy corneas of lumican null mice. Transplantation of umbilical mesenchymal stem cells significantly improved corneal transparency and increased stromal thickness of lumican null mice, but human umbilical hematopoietic stem cells failed to do the same. Further studies revealed that collagen lamellae were re-organized in corneal stroma of lumican null mice after mesenchymal stem cell transplantation. Transplanted umbilical mesenchymal stem cells survived in the mouse corneal stroma for more than 3 months with little or no graft rejection. In addition, these cells assumed a keratocyte phenotype, e.g., dendritic morphology, quiescence, expression of keratocyte unique keratan sulfated keratocan and lumican, and CD34. Moreover, umbilical mesenchymal stem cell transplantation improved host keratocyte functions, which was verified by enhanced expression of keratocan and aldehyde dehydrogenase class 3A1 in lumican null mice. CONCLUSIONS/SIGNIFICANCE: Umbilical mesenchymal stem cell transplantation is a promising treatment for congenital corneal diseases involving keratocyte dysfunction. Unlike donated corneas, umbilical mesenchymal stem cells are easily isolated, expanded, stored, and can be quickly recovered from liquid nitrogen when a patient is in urgent need.

  20. Viscoelastic evaluation of fetal umbilical vein for reconstruction of middle cerebral artery

    Institute of Scientific and Technical Information of China (English)

    Dongyuan Li; Donghui Xu; Peng Li; Jun Wei; Kun Yang; Conghai Zhao

    2013-01-01

    The transplantation of artificial blood vessels with<6 mm inner diameter as substitutes for human arterioles or veins has not achieved satisfactory results. Umbilical vein has been substituted for ar-tery in vascular transplantation, but it remains unclear whether the stress relaxation and creep tween these vessels are consistent. In this study, we used the fetal umbilical vein and middle cere-bral artery from adult male cadavers to make specimens 15 mm in length, 0.196-0.268 mm in nica media thickness, and 2.82-2.96 mm in outer diameter. The results demonstrated that the stress decrease at 7 200 seconds was similar between the middle cerebral artery and fetal umbilical vein specimens, regardless of initial stress of 18.7 kPa or 22.5 kPa. However, the strain increase at 7 200 seconds of fetal umbilical veins was larger than that of middle cerebral arteries. Moreover, the stress relaxation experiment showed that the stress decrease at 7 200 seconds of the fetal umbilical vein and middle cerebral artery specimens under 22.5 kPa initial stress was less than the decrease in these specimens under 18.7 kPa initial stress. These results indicate that the fetal umbilical vein has appropriate stress relaxation and creep properties for transplantation. These properties are advantageous for vascular reconstruction, indicating that the fetal umbilical vein can be transplanted to repair middle cerebral artery injury.

  1. Marcas de Mordida e a Identificação Humana

    OpenAIRE

    Almeida, Cristiana Vanessa dos Santos

    2012-01-01

    A Medicina Dentária Forense assume um papel primordial na identificação humana e na investigação criminal desde a antiguidade, e a sua recente visibilidade está relacionada com o aparecimento de situações que conduziram à necessidade de evolução das técnicas de identificação. O estudo das marcas de mordida constitui uma das formas de identificação humana de importante relevo para esta área, auxiliando na exclusão ou inclusão dos seus potenciais autores. Estas podem ser observadas em vários...

  2. ¿Qué pasa en el cerebro de los perros cuando ven caras humanas?

    Directory of Open Access Journals (Sweden)

    Laura V. Cuaya

    2016-05-01

    Full Text Available Cuando tu perro te ve, no sólo se iluminan sus ojos, también su cerebro. Aquí resumimos un experimento que realizamos para conocer el procesamiento cerebral de las caras humanas en perros, utilizando imágenes de resonancia magnética funcional, en el que encontramos actividad en la corteza temporal, frontal y el núcleo caudado. La actividad en la corteza temporal sugiere que los perros procesan las caras de manera similar a nosotros. Fue inesperado encontrar actividad en el núcleo caudado, porque sugiere que los perros procesan las caras humanas como recompensas, incluso si son caras de humanos desconocidos.

  3. A formação humana na perspectiva histórico-ontológica

    OpenAIRE

    Dermeval Saviani; Newton Duarte

    2010-01-01

    El tema de la formación humana está en el centro de la filosofía de la educación cuyo objetivo es precisamente el proceso de promoción humana, llevado a cabo por la educación. Partiendo de la vigilancia crítica, propia de la filosofía, el texto esboza una fenomenología de la época actual comprobando que las ideas actualmente hegemónicas en la educación, son centradas en la crítica a la razón y a las nociones de la verdad y de la objetividad. A ese neo pragmatismo que con la intención de opon...

  4. Seguridad humana en Colombia: donde no hay bienestar no puede haber paz

    Directory of Open Access Journals (Sweden)

    María Teresa Aya Smitmans

    2006-11-01

    Full Text Available Este artículo trata sobre los retos que amenazan a la soberanía clásica en el sistema internacional y, en especial, a la seguridad humana. Ésta, entendida como una concepción ampliada de la seguridad tradicional, refuerza la idea del individuo como centro de las relaciones internacionales y pone su seguridad por encima de la seguridad estatal. Asimismo, el surgimiento de nuevos actores hacen que la gobernabilidad estatal se vea debilitada a menos que se piense en aumentar la responsabilidad estatal para con sus ciudadanos. Es así como la seguridad humana constituye un concepto importante en el siglo XXI para una gobernabilidad responsable. El artículo examina el caso colombiano.

  5. Manifestaciones psiquiátricas desencadenadas por el virus de la inmunodeficiencia humana

    OpenAIRE

    Roberto Anselmo Ramos Valverde

    2014-01-01

    La alta morbilidad de perturbaciones mentales y del comportamiento, desencadenada por el virus de la inmunodeficiencia humana (VIH), asombra a colaboradores cubanos en la ciudad de Maputo, capital de Mozambique. Solo apelando a los conocimientos actuales de la Psicoendocrinoneuroinmunologia, que describe la vinculación basada en la teoría de la complejidad de este suprasistema, que comparte receptores y mediadores químicos, se puede disipar el asombro y llegar a comprender la esencia científi...

  6. A vida humana como “problema” e “projecto” em J. Ortega y Gasset

    OpenAIRE

    Amoedo, Margarida I. Almeida

    2014-01-01

    O capítulo parte da afirmação de que todos os escritos de Ortega y Gasset contribuem para a tematização da vida humana, mas acaba por destacar apenas aqueles em que é evidente, como marca do autor e indissociável do seu conceito de "projecto", o reconhecimento e afirmação do carácter problemático da vida.

  7. A formação humana na perspectiva histórico-ontológica

    Directory of Open Access Journals (Sweden)

    Dermeval Saviani

    2010-01-01

    Full Text Available El tema de la formación humana está en el centro de la filosofía de la educación cuyo objetivo es precisamente el proceso de promoción humana, llevado a cabo por la educación. Partiendo de la vigilancia crítica, propia de la filosofía, el texto esboza una fenomenología de la época actual comprobando que las ideas actualmente hegemónicas en la educación, son centradas en la crítica a la razón y a las nociones de la verdad y de la objetividad. A ese neo pragmatismo que con la intención de oponerse a la metafísica acaba siendo profundamente metafísico reduciendo todo al lenguaje, los autores contraponen el pensamiento de Marx como una filosofía de historicismo en que la causa no son los sujetos abstractos, sino los individuos reales, sujetos históricos que se constituyen como síntesis de relaciones sociales. Para esto se recurre a la reflexión histórica ontológica sobre la formación humana incluida en los "Manuscritos Económico Filosóficos de 1844" de Marx. El artículo concluye con la defensa de la tesis de que el acceso a los clásicos es condición necesaria para la formación humana.

  8. Pseudoaneurismas em associacao com infeccao pelo virus da imunodeficiencia humana: relato de dois casos

    Directory of Open Access Journals (Sweden)

    Guilon Otavio Santos Tenorio

    2013-09-01

    Full Text Available Os autores descrevem os casos de dois pacientes que apresentaram pseudoaneurismas e ressaltam a dificuldade diagnóstica e terapêutica por apresentar associação com a infecção pelo vírus da imunodeficiência humana, e também demonstram a semelhança com aneurisma sacular aterosclerótico da aorta abdominal

  9. FORMAÇÃO HUMANA: CURRÍCULO PARA O DESENVOLVIMENTO HUMANO

    Directory of Open Access Journals (Sweden)

    Adreana Dulcina Platt

    2009-09-01

    Full Text Available No presente artigo pretendemos debater a análise crítico-reflexiva das premissas que sustentam a práxis da formação humana perpassando transversalmente os conceitos de desenvolvimento humano e o currículo. Entendemos o currículo de formação humana a partir da filosofia da práxis. Coadunando com nossas perspectivas epistemológicas, concordamos com a leitura de Semeraro (2001b, quando aponta que Gramsci melhor desvela o processo de elaboração da filosofia da práxis a partir de novas relações sociais; ou seja, desligado das puras abstrações, o filósofo italiano observa na “unidade das tensões dualistas e as contradições ricas e complexas” (“entre teoria/prática, intelectuais/massa, organização/espontaneidade, sociedade política/sociedade civil, ocidente/oriente, norte/sul, história do mundo/história particular”, a articulação para o desenvolvimento da atividade humana plena. A partir destes pressupostos colocados aqui enquanto premissas para a sistematização de nossos estudos, nos debruçaremos sobre dois grandes objetivos: (1 compreender o processo de humanização a partir da esfera das objetivações sociais e (2 a constituição do currículo de formação humana atrelado aos diferentes modos de produção, uma vez que demanda em diferentes formações sociais.

  10. Hallazgo de impresiones de uñas humanas en un fragmento de cerámica aborigen de Cuba

    OpenAIRE

    Manuel F. Rivero de la Calle; Santiago F. Silva García

    2008-01-01

    Se da a conocer un conjunto de impresiones de uñas humanas, las que aparecen en la cara externa del fondo de una cazuela aborigen recuperada en el sitio arqueológico agroalfarero Toma de Agua, municipio La Sierpe, provincia Sancti Spíritus. En la cara interna del ejemplar se descubre también dos pequeños trazos que se identifican así mismo como correspondientes a uñas humanas.

  11. Persistent Umbilical Discharge from an Omphalomesenteric Duct Cyst Containing Gastric Mucosa

    Directory of Open Access Journals (Sweden)

    Kanimozhi Tamilselvan

    2012-01-01

    Full Text Available Umbilical discharge in infancy is often attributed to infection or an umbilical granuloma. It is important to investigate if such a discharge is due to an underlying congenital abnormality because corrective surgical intervention may then be required. We present the first case of an infant with a persistent umbilical discharge from an omphalomesenteric duct cyst. The discharge was associated with periumbilical dermatitis. The dermatitis was most likely due to irritation of the skin by gastric acid produced by the ectopic gastric mucosa contained in the omphalomesenteric duct cyst. Both discharge and dermatitis resolved after surgical removal of the cyst.

  12. Mercury in the Umbilical Cord: Implications for Risk Assessment for Minamata Disease

    DEFF Research Database (Denmark)

    Dalgård, Christine; Grandjean, Philippe; Jørgensen, Poul Jørgen;

    1994-01-01

    in umbilical cord blood and in maternal hair. The results were compared with published values for mercury in umbilical cord tissue from 12 infants diagnosed with congenital methylmercury poisoning in Minamata, Japan. From the regression coefficients obtained in the Faroese samples, the median umbilical cord...... mercury concentration of 4.95 nmol/g dry weight in Minamata would correspond to 668 nmol/l cord blood and 114 nmol/g maternal hair. These levels agree well with other evidence of susceptibility of the fetus to increased exposure to methylmercury....

  13. Diffuse Endometritis in the Setting of Umbilical Endometriosis: A Case Report

    Science.gov (United States)

    Kimball, Kristopher J.; Gerten, Kimberly A.; Conner, Michael G.; Richter, Holly E.

    2011-01-01

    Background Umbilical endometriosis is rare and can be a challenging diagnosis in the absence of classic signs and symptoms. Case A case of severe primary spontaneous umbilical endometriosis with foci of plasma cell endometritis and diffuse stromal lymphvascular presence is reported. Conclusion Despite a lengthy differential, endometriosis must be considered in the evaluation of an umbilical mass. The presence of plasma cell endometritis and stromal lymphvascular elements in the absence of pelvic endometriosis lend evidence to the theory of lymphvascular transport as an etiology of extra-pelvic endometriosis. PMID:18251362

  14. Aspectos médico legales de la clonación humana

    Directory of Open Access Journals (Sweden)

    Marco Mairena Navarro

    2002-09-01

    Full Text Available Las técnicas de reproducción asistida, y entre ellas la clonación humana, suscitan interrogantes éticas. Su empleo promete beneficios para la humanidad y, específicamente para parejas infértiles la satisfacción de ser madres y padres. En este artículo se debaten las regulaciones y las implicaciones jurídicas de dicha actividad, actualizándonos en el acontecer mundial y nacional del tema. Se argumenta que la clonación humana ya es una realidad y como si esta técnica se regula promueve la vida y la dignidad humanas. Además se propone que esta técnica se entiende mejor no en términos moralistas, sino contextuales que responden a situaciones reales de la vida, específicamente una ética de la responsabilidad.The techniques of assisted reproduction, among them human cloning, rises ethical questions. Their use promises benefits for humanity and, specifically for infertile couples, the satisfaction of being parents. This article discusses the regulations and juridical implications of this activity, trying to take us into the actual international and national reality. lt is argued that human cloning promotes human life and dignity. In addition, it is proposed that this technique is best understood not in moralistic terms, but rather in terms of contexts that respond to real life situations, specifically an ethics of responsibility.

  15. Human umbilical cord blood cells and diabetes mellitus: recent advances.

    Science.gov (United States)

    Reddi, Alluru S; Kothari, Neil; Kuppasani, Kishore; Ende, Norman

    2015-01-01

    Stem cell therapy for patients with diabetes is an area of great interest to both scientists and clinicians. Human umbilical cord blood cells (HUCBCs) are being increasingly used as a source of stem cells for cell-based therapy for diabetes because these cells can differentiate into pancreatic islet β-cells. Administration of HUCBCs has been shown to lower blood glucose levels in diabetic animal models. The use of autologous HUCBC transfusion in type 1 diabetic children has not shown any benefit. However, "Stem Cell Educator" therapy has shown promise in long term lowering of blood glucose levels in both type 1 and type 2 diabetic patients. In this review, we will briefly discuss recent advances in HUCBC therapy in the treatment of diabetes and some of its complications.

  16. Strength Analysis Modelling of Flexible Umbilical Members for Marine Structures

    Directory of Open Access Journals (Sweden)

    S. Sævik

    2012-01-01

    Full Text Available This paper presents a 3-dimensional finite element formulation for predicting the behaviour of complex umbilical cross-sections exposed to loading from tension, torque, internal and external pressure including bending. Helically wound armours and tubes are treated as thin and slender beams formulated within the framework of small strains but large displacements, applying the principle of virtual displacements to obtain finite element equations. Interaction between structural elements is handled by 2- and 3-noded contact elements based on a penalty parameter formulation. The model takes into account a number of features, such as material nonlinearity, gap and friction between individual bodies, and contact with external structures and with a full 3-dimensional description. Numerical studies are presented to validate the model against another model as well as test data.

  17. Morphological aspects of buffaloes (Bubalus bubalis umbilical cord Aspectos Morfológicos do cordão umbilical de búfalos (Bubalus bubalis

    Directory of Open Access Journals (Sweden)

    Guilherme J. Ferreira

    2009-10-01

    Full Text Available Buffalo is an important livestock resource, with a great participation in agricultural systems, providing milk, meat, and work power. Umbilical cord is responsible for maternal-fetal nutrients exchange during pregnancy, and its alterations can compromise the fetal development. We investigated ten pregnant uteruses collected from cross-bread buffaloes in different stages of gestation. Pregnancy and fetal age was determined by measuring the apex sacral length and development period was calculated by previously published formula. Umbilical cords were measured for length determination. Umbilical cord vascular net and anastomosis were observed by injection of Neoprene latex. Histological sections of the umbilical cord were studied after stain with HE, picrossirius, toluidine blue, orceine, and PAS reaction. Buffaloes' umbilical cord was formed by two central arteries, an allantois duct and two peripheral veins. The artery wall was composed by large quantity of collagen, elastic fibers, fibroblasts and large number of vasa vasorum. The allantois duct was located between the arteries and presented a great number of small nourishing vessels. Small nourishing vessels should be carefully considered to avoid to be mistaken to the arterials and veins vasa vasorum. Medium length of umbilical cord from buffalos was 11.8cm (minimum of 6.8cm and maximum of 17.4cm.Búfalo é uma importante fonte de recurso nos rebanhos animais, apresentando uma grande participação na agropecuária, provendo leite, carne e força de trabalho. O Cordão umbilical é responsável pela troca de nutrientes materno-fetais durante a gestação, e suas alterações podem comprometer o desenvolvimento fetal. Nós investigamos dez úteros gravídicos de búfalos de raças cruzadas em fases diferentes de gestação. O período de gestação e a idade fetal foram determinados pelo comprimento ápice sacral, aplicando fórmulas previamente estabelecidas. Posteriormente mediu-se o

  18. Umbilical cord mesenchymal stem cells: adjuvants for human cell transplantation.

    Science.gov (United States)

    Friedman, Robb; Betancur, Monica; Boissel, Laurent; Tuncer, Hande; Cetrulo, Curtis; Klingemann, Hans

    2007-12-01

    The Wharton's jelly of the umbilical cord is rich in mesenchymal stem cells (UC-MSCs) that fulfill the criteria for MSCs. Here we describe a novel, simple method of obtaining and cryopreserving UC-MSCs by extracting the Wharton's jelly from a small piece of cord, followed by mincing the tissue and cryopreserving it in autologous cord plasma to prevent exposure to allogeneic or animal serum. This direct freezing of cord microparticles without previous culture expansion allows the processing and freezing of umbilical cord blood (UCB) and UC-MSCs from the same individual on the same day on arrival in the laboratory. UC-MSCs produce significant concentrations of hematopoietic growth factors in culture and augment hematopoietic colony formation when co-cultured with UCB mononuclear cells. Mice undergoing transplantation with limited numbers of human UCB cells or CD34(+) selected cells demonstrated augmented engraftment when UC-MSCs were co-transplanted. We also explored whether UC-MSCs could be further manipulated by transfection with plasmid-based vectors. Electroporation was used to introduce cDNA and mRNA constructs for GFP into the UC-MSCs. Transfection efficiency was 31% for cDNA and 90% for mRNA. These data show that UC-MSCs represent a reliable, easily accessible, noncontroversial source of MSCs. They can be prepared and cryopreserved under good manufacturing practices (GMP) conditions and are able to enhance human hematopoietic engraftment in SCID mice. Considering their cytokine production and their ability to be easily transfected with plasmid-based vectors, these cells should have broad applicability in human cell-based therapies. PMID:18022578

  19. GAMMAGRAFÍA CON 99TC-MIBI PARA DETERMINAR LA EFECTIVIDAD DE LA HEBERQUINASA PARA REPERFUNDIR LA ARTERIA RELACIONADA CON EL INFARTO / 99tc-mibi gammagraphy to determine Heberkinase effectiveness in the reperfusion of the infarction-related artery

    OpenAIRE

    Marilyn Ramírez Méndez; Luis Castañeda Casarvilla; Iguer F. Aladro Miranda; Francisco Luis Moreno-Martínez; Carlos M. Osorio Gómez; Rudy Hernández Ortega; Marisel I. Noda Valledor

    2010-01-01

    Resumen Introducción y objetivos: La utilización de técnicas nucleares para la determinación de la permeabilidad de la arteria relacionada con el infarto, es de gran importancia clínica. El objetivo de esta investigación fue conocer el estado de la perfusión miocárdica del territorio dependiente de la irrigación de esa arteria y determinar la presencia o no de su reapertura después de la trombólisis. Método: Se realizó una investigación experimental puntual con una muestra de 10 pacientes con...

  20. Acetylcholine secretion by motor neuron-like cells from umbilical cord mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    Xueyuan Liu; Dehua Li; Dong Jiang; Yan Fang

    2013-01-01

    Umbilical cord mesenchymal stem cel s were isolated by a double enzyme digestion method. The third passage of umbilical cord mesenchymal stem cel s was induced with heparin and/or basic fi-broblast growth factor. Results confirmed that cel morphology did not change after induction with basic fibroblast growth factor alone. However, neuronal morphology was visible, and microtu-bule-associated protein-2 expression and acetylcholine levels increased fol owing induction with heparin alone or heparin combined with basic fibroblast growth factor. Hb9 and choline acetyl-transferase expression was high fol owing inductive with heparin combined with basic fibroblast growth factor. Results indicate that the inductive effect of basic fibroblast growth factor alone was not obvious. Heparin combined with basic fibroblast growth factor noticeably promoted the differen-tiation of umbilical cord mesenchymal stem cel s into motor neuron-like cel s. Simultaneously, um-bilical cord mesenchymal stem cel s could secrete acetylcholine.

  1. Experimental and numeric studies of one electro-optical flexible pipe (umbilical); Estudos numericos e experimentais de um umbilical eletro-optico

    Energy Technology Data Exchange (ETDEWEB)

    Lepore, Paula Ferreira; Buelta Martinez, Miguel Angel [Sao Paulo Univ., SP (Brazil). Escola Politecnica

    2005-07-01

    This work had as objective to develop, to implant, to survey and to test an experimental and numerical model of structural, applicable analysis of umbilical structures. An ample study of the behavior of its constituent layers was carried through, in special of its nucleus and material constituents, when operating under different conditions of tensions and deformations. As support for this work, experimental tests for one type of electro-optic umbilical with typical transversal section had been carried through. This was made with the intention to optimize the developed numerical model. With this model of structural analysis, the project of umbilicals could highly improved, in terms of the total weight of the handle, which is one of the great problems for its use in great depths, with the maximum of efficiency and the minimum of losses, foreseeing and hindering operation imperfections that can come to occur due to extreme deformation or electric rupture of the layers, hoses or handles. (author)

  2. A PROSPECTIVE STUDY OF FACTORS INFLUENCING THE TIME OF SEPARATION OF UMBILICAL CORD

    Directory of Open Access Journals (Sweden)

    Lokesha

    2014-12-01

    Full Text Available : BACKGROUND: The umbilical cord usually shrivels and falls off at around 5 to 15days of life. It is important to know timing of separation, so that parents may be advised on proper cord care and ally any misconceptions about the cord separation; early discharge has increased the need for women to receive accurate, relevant information on how to care for themselves and their newborns when discharged from the hospital. Delay in separation of the umbilical cord, umbilical discharge, odor, or granuloma causes concern and source of immense anxiety for parents, the interval between delivery and umbilical cord separation varies worldwide, this study is undertaken to determine time of separation and factors influencing the separation. OBJECTIVES: To determine time of separation of umbilical cord and factors influencing it. METHODS: SETTINGS: Babies admitted at a tertiary hospital, selected by purposive sampling technique. For each recruited baby, data is obtained about mother's parity, mode of delivery, gestational age, birth weight, and gender of baby, method of resuscitation, phototherapy, IV antibiotics, and cord blood TSH values, time of umbilical cord separation after birth. Newborns whose umbilical cord shriveled off during the stay in the hospital information were obtained directly, and a self-addressed postcard was given to parents of newborns whose umbilical cord was intact at time of discharge. Parents would be advised to note and write the date of fall of umbilical cord on post card and mail it. RESULTS: Cord separation time ranges from 3 to 11 days, with mean separation of 5.62 ± 2.37 days, it is one to two days earlier as compared to previous studies, seventy nine (79 of hundred and ten (110 separated between 5-7 days (71%, one baby had separation at 11days, babies who received antibiotics had statistically significant delay in separation time of umbilical, neonates received antibiotics had mean separation time (6 ± 2.4 days as compared

  3. The Umbilical Benz Incision for Reduced Port Surgery in Pediatric Patients

    OpenAIRE

    AMANO, HIZURU; Uchida, Hiroo; Kawashima, Hiroshi; Deie, Kyoichi; Murase, Naruhiko; Makita, Satoshi; Yokota, Kazuki; Tanaka, Yujiro

    2015-01-01

    Background and Objectives: For reduced port surgery in pediatric patients, the initial umbilical incision plays an important role in both functional ability and cosmetic impact. Larger umbilical incisions enable better manipulation of forceps, extraction of larger surgical specimens, and easier exteriorization of the intestine for anastomosis. We have pursued an incision of the small pediatric umbilicus that allows for enlargement of the orifice of the abdominal opening with preservation of t...

  4. Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy

    OpenAIRE

    Eder Zucconi; Natassia Moreira Vieira; Carlos Roberto Bueno; Mariane Secco; Tatiana Jazedje; Marcos Costa Valadares; Miriam Fussae Suzuki; Paolo Bartolini; Mariz Vainzof; Mayana Zatz

    2011-01-01

    Umbilical cord mesenchymal stromal cells (MSC) have been widely investigated for cell-based therapy studies as an alternative source to bone marrow transplantation. Umbilical cord tissue is a rich source of MSCs with potential to derivate at least muscle, cartilage, fat, and bone cells in vitro. The possibility to replace the defective muscle cells using cell therapy is a promising approach for the treatment of progressive muscular dystrophies (PMDs), independently of the specific gene mutati...

  5. Diagnostic efficacy of biophysical tests and cerebral-umbilical index when assessing fetal oxygenation

    Directory of Open Access Journals (Sweden)

    Čančarević-Đajić Branka

    2013-01-01

    Full Text Available Introduction. Perinatal morbidity and mortality are the ultimate indicators of antenatal care today, whose responsible task is to assess the respiratory function of the placenta, fetal growth and placental maturation in order to provide conditions for the delivery of a living and viable newborn. The diagnostic procedures of antenatal care tested within this study were the biophysical tests of cardiotocography and the fetal biophysical profile, along with the colour doppler evaluation of the cerebral-umbilical ratio. The objective of this study was to determine the most effective diagnostic procedure when assessing fetal oxygenation. Materials and Methods. The prospective study included 119 pregnant women. They all underwent cardiotocography, biophysical profile and colour doppler evaluation of the cerebral-umbilical ratio. The babies’ umbilical artery blood pH was determined in the first minute upon birth, along with the Apgar score. Results. The results were processed statistically and the most effective diagnostic procedure for the evaluation of fetal oxygenation was selected, after which the rates of perinatal morbidity and mortality were calculated. The findings revealed that cardiotocography was the most sensitive antepartal predictor of fetal acidosis, while the fetal biophysical profile proved the most specific. The rates of perinatal morbidity and of perinatal mortality were 24.37% and 1.68%, respectively. Conclusion. The findings analysis revealed a high statistical significance of both biophysical tests and the cerebral-umbilical ratio evaluation as predictors of the fetal distress syndrome. The analysis of the cerebral-umbilical ratio and biophysical tests showed that the cerebral-umbilical ratio evaluation not only was more sensitive as a parameter compared to biophysical tests but it was also more specific than cardiotocography. Cardiotocography is the most sensitive antepartal predictor of fetal acidosis, followed by the cerebral-umbilical

  6. Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia.

    OpenAIRE

    Guarner, J.; Southwick, K.; Greer, P; Bartlett, J; Santander, A.; Blanco, S.; Pope, V.; Levine, W.; Zaki, S.

    2000-01-01

    To establish the frequency of necrotizing funisitis in congenital syphilis, we conducted a prospective descriptive study of maternal syphilis in Bolivia by testing 1,559 women at delivery with rapid plasma reagin (RPR). We examined umbilical cords of 66 infants whose mothers had positive RPR and fluorescent treponemal antibody absorption tests. Histologic abnormalities were detected in 28 (42%) umbilical cords (seven [11%] had necrotizing funisitis with spirochetes; three [4%] had marked funi...

  7. A Review of Factors Influencing the Banking of Collected Umbilical Cord Blood Units

    OpenAIRE

    David Allan; Tanya Petraszko; Heidi Elmoazzen; Susan Smith

    2013-01-01

    Umbilical cord blood banking efforts have increased dramatically in the past two decades in response to increasing demand for alternative sources of blood stem cells to support patients requiring hematopoietic stem cell transplantation. Transplant centres have accumulated increasing expertise in their understanding of umbilical cord blood characteristics that are associated with improved outcome following transplantation. These characteristics and factors can assist transplant centres in sele...

  8. Prospect for vaginal delivery of growth restricted fetuses with abnormal umbilical artery blood flow.

    OpenAIRE

    Li, Hui; Gudmundsson, Saemundur; Olofsson, Per

    2003-01-01

    Background. The best mode of delivery in cases of intrauterine growth restriction (IUGR) with umbilical artery blood flow changes is not well elucidated. Objective. To evaluate outcome in IUGR with umbilical artery blood flow changes planned for vaginal delivery after a negative oxytocin challenge test (OCT). Methods. In 84 term singleton pregnancies with suspected IUGR and no unanimous indication for abdominal delivery, Doppler velocimetry and OCT were performed. Positive OCT c...

  9. A clinical report of entangled neonates' umbilical cord with queen's fur in Persian cat

    Institute of Scientific and Technical Information of China (English)

    O Azari; B Akhtardanesh

    2011-01-01

    A 3-year-old Persian queen was referred to Teaching Veterinary Hospital while 3 neonates' umbilical cords were entangled with the queen's tail hair. Close inspection of the cat showed that the umbilical cords of 3 kittens had twisted around together and entangled with the moms' hairs in the base of tail region. Also this complex has been warped around the left tarsus of one of the involved kittens and caused swelling and skin darkness in the involved limb. Operation was carried out urgently. After cutting the queen's involved hairs the kittens were released. Then the twisted umbilical cords and the hairs were isolated from the umbilical cord and the involved leg was released from the umbilical cords and the twisted umbilical cords were separated from each other. During one week follow up, dry gangrene occurred in the distal extremity of the injured limb and consequently, amputation was performed on the distal part of tibia. Our clinical findings suggest that long hair coats of queens could be a maternal life threatening factor for neonates' life.

  10. Epidermal Sutureless Closure of the Umbilical Base Following Laparoscopic Colectomy for Colon Cancer.

    Science.gov (United States)

    Shibasaki, Susumu; Homma, Shigenori; Yoshida, Tadashi; Kawamura, Hideki; Takahashi, Norihiko; Taketomi, Akinobu

    2016-06-01

    At our institute, a non-suturing method for closure of the umbilical epidermis has been used in laparoscopic colorectal resection to prevent umbilical wound infection. We performed a retrospective evaluation of the incidence of umbilical wound infection using this technique for patients with colorectal cancer. From 2010 to 2014, 178 consecutive patients underwent elective laparoscopic resection of colorectal cancer. The umbilical fascia was closed using interrupted multifilament absorbable sutures. The skin surface of the umbilicus was compressed using a cotton ball and sealed by water vapor-permeable film. Three (1.7 %) patients required conversion from laparoscopic to open surgery. The mean surgery time was 174 ± 48 min, intraoperative blood loss was 29 ± 75 mL, and postoperative hospital stay was 10.5 ± 6.7 days. According to the Centers for Disease Control and Prevention criteria, umbilical superficial wound infection occurred in two (1.1 %) patients. The two patients recovered from their wound infections after a few days of drainage, and their hospital discharge was not delayed. Deep umbilical wound infection did not occur in any patient. Our non-suturing closure technique appeared to be effective in preventing wound infection after laparoscopic resection of colon cancer. PMID:27358515

  11. Impact of ethanol, dry care and human milk on the time for umbilical cord separation

    International Nuclear Information System (INIS)

    Objective: To compare the extraction time and infection rate of umbilical cord by applying ethanol, human milk or dry care. Method: The parallel single-blinded randomised clinical trial was performed on 300 neonates at Shahid Sadougi University of Medical Sciences and Health Service, Yazd, Iran, between March and September 2010. The neonates were divided into three random but numerically equal groups. Each group was assigned the application of ethanol or mother's milk or to keep the stump dry. The neonates were visited on the 3rd and the 7th day after birth and follow-up was maintained telephonically until umbilical separation. Umbilical separation time and umbilical local infection frequency were considered as the study outcome, which was compared among the three groups according to age, gender and delivery type of the neonates. Results: Umbilical separation time in neonates of the human milk group had significant difference with the ethanol group (p=0.0001) and drying groups (p=0.003). Frequency of omphalitis had no significant difference among the three groups. Conclusion: Topical usage of human milk on umbilical cord stamp decreased separation time and incidence rate of omphalitis. (author)

  12. Double suicide genes selectively kill human umbilical vein endothelial cells

    Directory of Open Access Journals (Sweden)

    Liu Lunxu

    2011-02-01

    Full Text Available Abstract Background To construct a recombinant adenovirus containing CDglyTK double suicide genes and evaluate the killing effect of the double suicide genes driven by kinase domain insert containing receptor (KDR promoter on human umbilical vein endothelial cells. Methods Human KDR promoter, Escherichia coli (E. coli cytosine deaminase (CD gene and the herpes simplex virus-thymidine kinase (TK gene were cloned using polymerase chain reaction (PCR. Plasmid pKDR-CDglyTK was constructed with the KDR promoter and CDglyTK genes. A recombinant adenoviral plasmid AdKDR-CDglyTK was then constructed and transfected into 293 packaging cells to grow and harvest adenoviruses. KDR-expressing human umbilical vein endothelial cells (ECV304 and KDR-negative liver cancer cell line (HepG2 were infected with the recombinant adenoviruses at different multiplicity of infection (MOI. The infection rate was measured by green fluorescent protein (GFP expression. The infected cells were cultured in culture media containing different concentrations of prodrugs ganciclovir (GCV and/or 5-fluorocytosine (5-FC. The killing effects were measured using two different methods, i.e. annexin V-FITC staining and terminal transferase-mediated dUTP nick end-labeling (TUNEL staining. Results Recombinant adenoviruses AdKDR-CDglyTK were successfully constructed and they infected ECV304 and HepG2 cells efficiently. The infection rate was dependent on MOI of recombinant adenoviruses. ECV304 cells infected with AdKDR-CDglyTK were highly sensitive to GCV and 5-FC. The cell survival rate was dependent on both the concentration of the prodrugs and the MOI of recombinant adenoviruses. In contrast, there were no killing effects in the HepG2 cells. The combination of two prodrugs was much more effective in killing ECV304 cells than GCV or 5-FC alone. The growth of transgenic ECV304 cells was suppressed in the presence of prodrugs. Conclusion AdKDR-CDglyTK/double prodrog system may be a useful

  13. Detection of maternal DNA in umbilical cord plasma by fluorescent PCR amplification of short tandem repeat sequences.

    Science.gov (United States)

    Bauer, M; Orescovic, I; Schoell, W M; Bianchi, D W; Pertl, B

    2001-09-01

    Recently, maternal DNA was detected in umbilical cord blood using PCR amplification of minisatellite sequences. The presence of maternal DNA was demonstrated in 1% to 100% of umbilical cord blood samples. The objective of this study was to determine the frequency of cord blood contamination by maternal genetic material. We used fluorescent PCR amplification of highly polymorphic short tandem repeat (STR) markers to detect maternal DNA in umbilical cord plasma. PMID:11708473

  14. Propiedades mecánicas de la dentina humana Mechanical properties of human dentin

    Directory of Open Access Journals (Sweden)

    Mª V. Fuentes Fuentes

    2004-04-01

    Full Text Available Puesto que la dentina es el mayor constituyente de la estructura dental, su microestructura y sus propiedades son los principales determinantes en casi todos los procedimientos de Odontología restauradora. Este artículo trata de las siguientes propiedades mecánicas de la dentina humana: la resistencia cohesiva, la microdureza y el módulo de elasticidad.Since dentin is the major constituent of the teeth, dentin microstructure and their properties are principal determinants of nearly all procedures in restorative dentistry. This paper is about following mechanical properties of human dentin: cohesive strength, microhardness and modulus of elasticity.

  15. Propiedades mecánicas de la dentina humana Mechanical properties of human dentin

    OpenAIRE

    Mª V. Fuentes Fuentes

    2004-01-01

    Puesto que la dentina es el mayor constituyente de la estructura dental, su microestructura y sus propiedades son los principales determinantes en casi todos los procedimientos de Odontología restauradora. Este artículo trata de las siguientes propiedades mecánicas de la dentina humana: la resistencia cohesiva, la microdureza y el módulo de elasticidad.Since dentin is the major constituent of the teeth, dentin microstructure and their properties are principal determinants of nearly all proced...

  16. Movilidad cotidiana y sostenibilidad, una interpretación desde la Geografía Humana

    OpenAIRE

    Miralles-Guasch, Carme, 1961-; Cebollada Frontera, Àngel

    2009-01-01

    La movilidad cotidiana es un fenómeno creciente y complejo, integrado por diferentes dimensiones, que en los últimos tiempos esta siendo objeto de una revisión metodológica y conceptual, y la Geografía Humana no ha sido ajena a ello. El artículo ahonda en esta transformación desde tres perspectivas complementarias, los cambios en el modelo económicoterritorial,la introducción del paradigma de la sostenibilidad y la inclusión de la estructura social de la población móvil. Tres perspectivas que...

  17. A dignidade humana como afirmação histórica

    Directory of Open Access Journals (Sweden)

    Afonso Soares Oliveira Sobrinho

    2013-04-01

    Full Text Available Vivenciamos um mundo em que o econômico se sobrepõe ao político e as desigualdades sociais e culturais são tão marcantes e prevalece o consumismo sobre a vida tornando-a banal. A afirmação histórica da dignidade da pessoa humana como dimensão de direitos faz-se mister na busca pela efetividade dos direitos sociais no novo constitucionalismo.

  18. Seroprevalencia de hidatidosis humana en población adulta de Sancos, Ayacucho 2005

    OpenAIRE

    Vanessa García-Apaico; F. Hernán Vargas-Cuba; Gualberto Segovia; Illanov Fernández-Chillce; Eduardo Miranda

    2009-01-01

    Con el objetivo de determinar la seroprevalencia de hidatidosis humana en la población adulta de 18 a 65 años de edad residentes en el distrito de Sancos (Ayacucho) en la sierra central del Perú, se desarrolló un estudio descriptivo de corte transversal durante los meses de mayo a diciembre del año 2005. El diagnóstico de hidatidosis se realizó primero con un tamizaje con ELISA y las que fueron positivas se les realizó inmunoblot. De 355 personas estudiadas, 13 presentaron serología positiva ...

  19. La comunicación humana como objeto semiótico, una tarea en estudio

    OpenAIRE

    Riestra, Dora

    2007-01-01

    En la cultura occidental las relaciones entre las nociones y representaciones de lengua, lenguaje y pensamiento humanos han ido cambiando a lo largo de los siglos. En el transcurso del siglo XX, de los cruces producidos entre las teorías funcionalistas y los enfoques cognitivos en las teorías lingüísticas, las nociones de texto y discurso se resituaron como centro de la actividad comunicativa humana; al mismo tiempo, los enfoques pragmáticos fueron centrándose en nuevos objetos de investigaci...

  20. Mejora humana y dopaje en la actual filosofía del deporte

    OpenAIRE

    López Frías, Francisco Javier

    2014-01-01

    Esta tesis parte del hecho de que resulta esencial realizar una reflexión crítica sobre el deporte. Éste no sólo ejemplifica algunas de las características y capacidades que consideramos como más propiamente humanas, sino que los seres humanos que nos vemos relacionados con el deporte nos hacemos a través de él. Esto ha sido una constante a lo largo de la Historia. No hay más que ver que todas las civilizaciones anteriores a la nuestra han tenido una actividad deportiva que ha resultado centr...

  1. La conducta simbólica humana : nueva orientación metodológica

    OpenAIRE

    Ángel RIVERA ARRIZABALAGA

    2004-01-01

    El presente trabajo constituye un intento de análisis de la conducta simbólica humana, por medio de una síntesis metodológica elaborada con las aportaciones de varias ciencias relacionadas con los seres humanos (Arqueología, Biología evolutiva, Neurología, Psicología y Sociología). El resultado es un modelo Psicobiológico sobre el comportamiento humano en todas sus fases de evolución cultural. Su desarrollo facilita el inicio de una nueva vía explicativa sobre el origen y evolución ...

  2. Competencias distintivas en las pymes: un aporte desde gestión humana

    OpenAIRE

    Gregorio Calderón Hernández

    2006-01-01

    Con el fin de establecer de qué manera se está apoyando la competitividad por parte de la gestión humana en las pymes, se adelantó una investigación en 16 pequeñas y medianas unidades productivas de Manizales, en donde se estudiaron las competencias distintivas que más inciden sobre los factores de competitividad empresarial. Desde el punto de vista teórico se tomaron el enfoque sistémico de la competitividad, la teoría de recursos y capacidades, y la perspectiva estratégica de la gestión hum...

  3. Componentes prenatal y postnatal de la diferenciación craneofacial entre dos poblaciones humanas

    OpenAIRE

    Sardi, Marina Laura; Ramirez Rozzi, Fernando V.; Pucciarelli, Héctor Mario

    2007-01-01

    Parte importante de la diferenciación craneofacial interpoblacional ya está presente en etapas tempranas de la ontogenia postnatal. Sin embargo, se desconoce qué parte de la diferenciación se produce en la etapa prenatal. El objetivo de este estudio es evaluar la diferenciación craneofacial entre dos poblaciones humanas en dos etapas ontogénicas: menores de 1 año de edad y adultos, a fin de determinar que parte de la diferenciación se produce en la etapa prenatal y en la postnatal. Se estudia...

  4. EL PRINCIPIO DE LA DIGNIDAD HUMANA COMO FUNDAMENTO DE UN BIODERECHO GLOBAL

    Directory of Open Access Journals (Sweden)

    Ángela Aparisi Miralles

    2013-01-01

    Full Text Available El término dignidad posee muchos significados. Ello se debe a que designa una realidad muy rica, que puede ser contemplada desde diversas perspectivas. Entre dichas acepciones, destaca la que entiende la dignidad como un principio ético-jurídico, fundamento de la bioética y el bioderecho. El objetivo de este trabajo es aproximarnos, muy someramente, a dicho sentido. Para ello, se expondrán, brevemente, las concepciones personista y utilitarista del mismo. Finalmente, y como alternativa a las insuficiencias de estas visiones, se propone la concepción ontológica de la dignidad humana.

  5. Aspectos funcionais respiratórios na leptospirose humana Respiratory functional characteristics of human leptospirosis

    OpenAIRE

    Ana Paula Argolo Fontes; Diogo Piva Ribeiro; Larissa Smith Barreto de Jesus; Maria Luíza Dória Almeida; Ângela Maria da Silva

    2010-01-01

    INTRODUÇÃO: O comprometimento respiratório da leptospirose humana pode ser sua principal manifestação clínica e comumente está associado a maior morbimortalidade. MÉTODOS: Objetivando descrever aspectos funcionais respiratórios nessa doença, foram analisados 21 pacientes com oximetrias de pulso e espirometrias em dois momentos: em avaliação inicial e após cerca de 28 dias. RESULTADOS: Dois (9,5%) doentes tinham saturação periférica de oxigênio menor que 95%. Padrões espirométricos normais for...

  6. De la rabia humana de origen canino y otras vergüenzas

    OpenAIRE

    Nelson Alvis G

    2006-01-01

    Colombia invierte cerca de diez puntos de su PIB en salud, sin embargo, sus indicadores desalud pública desdicen de la efectividad de su sistema sanitario. A las ya altas tasas deprevalencia e incidencia de patologías controlables o erradicables, como malaria, dengueclásico y hemorrágico, fiebre amarilla, tuberculosis, cólera y leishmaniasis, se agrega otravergüenza: los brotes de rabia humana de origen canino recientemente observados en laregión caribe colombiana.La rabia es una enfermedad l...

  7. Métodos de gene tangeting en células humanas

    OpenAIRE

    Bernardi, María Alejandra

    2012-01-01

    Se diseñaron plásmidos, con los cuales fue posible obtener vectores AAV recombinantes (virus adenoasociados recombinantes) con el fin de aumentar la recombinación homóloga en células humanas y generar una modificación génica en un sitio de interés en el genoma humano. Esto se ha conseguido de manera efectiva, aunque la frecuencia de recombinación homóloga sigue siendo aún muy baja.

  8. Cambio Global. Impacto de la Actividad Humana sobre el Sistema Tierra

    OpenAIRE

    Alonso Oroza, Sergio; Benito, Gerardo; Dachs, Jordi; Duarte, Carlos M.; Montes, Carlos; Pardo, Mercedes; Ríos, Aida F.; Simó, Rafel; Valladares Ros, Fernando

    2006-01-01

    Esta obra, dirigida al público en general y elaborada por un equipo interdisciplinar, aborda con un lenguaje claro y asequible pero sin renunciar al rigor científico, el complejo problema del cambio global, un desafío de dimensiones colosales para la humanidad. El cambio global se define en esta obra como el conjunto de cambios en los procesos fundamentales que definen el funcionamiento de la biosfera derivados de la actividad humana. Los autores describen las múltiples dimensiones del cam...

  9. La Placenta Humana Nuevo Sustrato Proteico Empleado para la Obtención de Bases Nutritivas.

    OpenAIRE

    Diana Rosa Viera Oramas; Mileydis Grillo Díaz; Claudio Rodríguez Martínez; Raisa Zhurbenko

    2005-01-01

    El hidrolizado de placenta humana es una nueva base nutritiva con un elevado contenido de nutrientes y constituyen un paso importante en el desarrollo de una metodología para su obtención a partir de residuos de placenta. Además de ser un nuevo producto en la gama de BIOCEN y brindar la posibilidad de utilizar en sustitución de bases nutritivas importadas. Con el objetivo de desarrollar y evaluar la funcionalidad de dicha base se realizó un diseño experimental completamente aleatorio, se estu...

  10. Evolución y emergencia de algunas enfermedades animales y humanas

    OpenAIRE

    Blancou, Jean M.

    2000-01-01

    La atención de la opinión pública está particularmente centrada desde hace unos años en la evolución de las enfermedades animales y humanas que pueden entrañar un riesgo sanitario. Aunque ese riesgo se ha exagerado considerablemente, si se compara con el que siempre ha existido en nuestro planeta, no debe sin embargo ser ignorado. En realidad, ese riesgo se basa en una tendencia a la evolución de los agentes patógenos que se observa actualmente, tanto en medicina veterinaria como en medici...

  11. Myiasis gastrointestinal humana por Eristalis tenax Gastrointestinal human myiasis for Eristalis tenax

    Directory of Open Access Journals (Sweden)

    Marcelo Kun

    1998-08-01

    Full Text Available Son caracterizadas las myiasis registradas en Bariloche y establecidas las condiciones probables bajo las cuales se produjeron las infestaciones. Las larvas obtenidas a partir de heces de 2 pacientes fueron identificadas como Eristalis tenax (Diptera: Syrphidae de acuerdo a las claves de Hartley (1961 y Organización Panamericana de la Salud (1962. Estos 2 casos de myiasis gastrointestinal humana constituyen los primeros registrados en Bariloche (Patagonia, Argentina y sus características responden a las registradas para esta especie de Díptera en otras partes del mundo. La falta de control específico en el sistema domiciliario de suministro de agua ha sido la causa más probable de la infestación. Este registro extiende la distribución de E. tenax y de las myiasis gastrointestinales humanas en América del Sur hasta los 41º 03' S.Foram caracterizadas as miasis registradas em Bariloche (Patagonia, Argentina e estabelecidas as prováveis condições sob as quais são produzidas as infestações. As larvas obtidas a partir das fezes de dois pacientes foram identificadas como Eristalis tenax (Diptera: Syrphdae. Esses dois casos de miasis gastrointestinal humana foram os primeiros registrados em Bariloche, Argentina, e suas características respondem às registradas para esta espécie de Diptera em outras partes do mundo. A falta de controle específico no sistema domiciliário de abastecimento de água tem sido a causa mais provável de infestação. Este registro amplia a distribuição de E. tenax e das miasis gastrointestinais humanas em América do Sul até os 41º 03's.The myiasis observed in Bariloche are characterized and the probable conditions under which the infestations took place established. The larvae obtained from faeces of 2 patients were identified as Eristalis tenax (Diptera: Syrphidae according to Hartley (1961 and Organización Panamericana de la Salud keys (1962. These 2 cases of human gastrointestinal myiasis were the

  12. Biomarcadores de daño genético en poblaciones humanas expuestas a plaguicidas

    OpenAIRE

    AIASSA, DELIA; Mañas, Fernando; Bosch, Beatriz

    2012-01-01

    El efecto de los plaguicidas sobre la salud humana, animal y ambiental es preocupación de la comunidad científica desde hace mucho tiempo. Numerosos estudios reportan que los plaguicidas no son inofensivos y que su uso puede conducir a efectos biológicos dañinos a mediano y a largo plazo, en los grupos humanos y animales expuestos, en el presente o en los descendientes. La importancia en la detección precoz del daño genético radica en que permite tomar las medidas necesarias para disminuir o ...

  13. Pregnant women's perspectives on umbilical cord blood banking.

    Science.gov (United States)

    Sugarman, J; Kaplan, L; Cogswell, B; Olson, J

    1998-08-01

    Promising clinical results suggest that umbilical cord blood (UCB) collected after delivery of a child may have many advantages over bone marrow for transplantation. As there are an increasing number of options regarding the collection of UCB, including private and public banking, more pregnant women are likely to be asked to make decisions about UCB collection. We conducted three focus groups with pregnant women to learn about their perspectives on this emerging technology. All the women in these focus groups indicated that they would choose to have UCB collected. Reasons leading to this choice were that the UCB would otherwise be discarded and altruism. Participants indicated that possible reasons to decide not to have UCB collected include concerns about the safety of the mother and neonate, beliefs about the placenta, threats against confidentiality, rejection of UCB, and the influence of fathers. While feeling confident in making an anticipatory decision about UCB collection, women expressed a clear desire to learn much more about the collection, storage (including distinctions between public and private banking), and use of UCB. In addition, they believed that recruitment for UCB collection should occur after sufficient education about UCB and certainly not after delivery and collection. These data will be useful in guiding efforts to help women make decisions about having UCB collected and in developing an appropriate recruitment and informed consent process for donating UCB to a public bank. PMID:9718543

  14. DERMATO FIBROSARCOMA PROTUBERANS IN UMBILICAL REGION: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Mythili Devi

    2015-01-01

    Full Text Available Dermatofibrosarcoma protuberans is a rare fibroblastic mesenchymal skin tumor with low - grade malignancy and occasional distant metastasis. The tumour accounts for less than 0.001% of all malignancies. Most cases involve the trunk, extremities, scalp, and neck. In rare cases, the genital urinary system may be affected. Diagnostic tools include computed tomography and magnetic resonance imaging. The standard treatment of wide - margin surgical excision with a clear margin of 3 - 4 cm may be problematic in large tumors or in some areas of the body, as a radical excision may produce unacceptable cosmetic, structural, or functional results. An un resected or positive margin should be treated with adjuvant radiotherapy to help prevent recurrence. Chemotherapy plays a limited role in treating this disease. This article describes a 55years male with mass in umbilical region who underwent wide local excision and rhombhoid flap transfer to cover the defect. Later patient sent for adjuvant radiotherapy, patient was tumour free at 6 months follow up.

  15. Improving engraftment and immune reconstitution in umbilical cord blood transplantation

    Directory of Open Access Journals (Sweden)

    Robert eDanby

    2014-02-01

    Full Text Available Umbilical cord blood (UCB is an important source of haematopoietic stem cells (HSC for allogeneic transplantation when HLA-matched sibling and unrelated donors (MUD are unavailable. Although the overall survival rates of UCB transplantation are comparable to the results with MUD, UCB transplants are associated with slow engraftment, delayed immune reconstitution, and increased opportunistic infections. While this may be a consequence of the lower cell dose in UCB grafts, it also reflects the relative immaturity of cellular immunity within cord blood. Furthermore, the limited number of cells and the non-availability of donor lymphocyte infusions (DLI currently prevent the use of post-transplant cellular immunotherapy to boost donor-derived immunity to treat infection, mixed chimerism and disease relapse. Therefore, to further develop UCB transplantation, many strategies to enhance engraftment and immune reconstitution are currently under investigation. This review summarises our current understanding of engraftment and immune recovery following UCB transplantation and why this differs from allogeneic transplants using other sources of HSC. It also provides an comprehensive overview of the promising techniques being used to improve myeloid and lymphoid recovery, including expansion, homing, and delivery of UCB HSC; combined use of UCB with third party donors; isolation and expansion of NK cells, pathogen specific T cells, and regulatory T cells; methods to protect and/or improve thymopoiesis. As many of these strategies are now in clinical trials, it is anticipated that UCB transplantation will continue to advance, further expanding our understanding of UCB biology and HSC transplantation.

  16. Leukocyte recovery from umbilical cord blood by poligeline.

    Science.gov (United States)

    Perutelli, P; Catellani, S

    1999-02-01

    Umbilical cord blood (UCB) collected at delivery is a source of transplantable stem/progenitor cells; it represents an alternative to bone marrow to restore hematopoiesis in patients affected by malignant and non-malignant disease. Therefore, large-scale UCB banks would be a natural complement to bone marrow donor registries. Storage of unmanipulated whole UCB units requires a great number of liquid nitrogen containers. Separation of leukocytes allows UCB storage in smaller space, thus lowering banking costs; unfortunately, UCB processing may cause significant losses of stem cells. We report about the use of poligeline to remove erythrocytes from UCB units. After erythrocyte sedimentation at 1xg (30' or 40') or 50xg, leukocyte-rich supernatant was collected and centrifuged to recover the leukocyte pool in view of stem cell transplantation. Erythrocyte depletion was always satisfactory, ranging from 82.6% to 88.9%, but 1xg sedimentation for 40' enabled us to achieve the best CD34+ cell recovery (mean value 80.5%). The proposed UCB-processing method allowed us to lower the final sample volume down to 1/10 of the initial one, in this way making UCB banking feasible. Erythrocyte depletion took place directly in the collection bag, thus reducing microbial contamination risk. PMID:10193639

  17. Intestinal Rotation and Physiological Umbilical Herniation During the Embryonic Period.

    Science.gov (United States)

    Ueda, Yui; Yamada, Shigehito; Uwabe, Chigako; Kose, Katsumi; Takakuwa, Tetsuya

    2016-02-01

    Drastic changes occur during the formation of the intestinal loop (IL), including elongation, physiological umbilical herniation (PUH), and midgut rotation. Fifty-four sets of magnetic resonance images of embryos between Carnegie stage (CS) 14 and CS 23 were used to reconstruct embryonic digestive tract in three dimensions in the Amira program. Elongation, PUH, and rotation were quantified in relation to the proximal part of the superior mesenteric artery (SMA), designated as the origin. Up to CS 16, IL rotation was initially observed as a slight deviation of the duodenum and colorectum from the median plane. The PUH was noticeable after CS 17. At CS 18, the IL showed a hairpin-like structure, with the SMA running parallel to the straight part and the cecum located to the left. After CS 19, the IL began to form a complex structure as a result of the rapid growth of the small intestinal portion. By CS 20, the IL starting point had moved from the right cranial region to an area caudal to the origin, though elongation of the duodenum was not conspicuous-this was a change of almost 180° in position. The end of the IL remained in roughly the same place, to the left of and caudal to the origin. Notably, the IL rotated around the origin only during earlier stages and gradually moved away, running transversely after CS 19. The movements of the IL may be explained as the result of differential growth, suggesting that IL rotation is passive. PMID:26599074

  18. Pertussis seroprevalence in adults, post-partum women and umbilical cord blood.

    Science.gov (United States)

    Fallo, Aurelia; Manonelles, Gabriela; Hozbor, Daniela; Lara, Claudia; Huespe, Miguel; Mazzeo, Silvina; Canle, Oscar; Galas, Marcelo; López, Eduardo

    2014-08-01

    Pertussis is a vaccine-preventable disease that affects people of all ages. Young adults who have lost their immunity to pertussis are the major source of infection in infants. Given the steady increase of pertussis cases, new prevention strategies are required. Objective. To assess pertussis seroprevalence in adult blood donors, post-partum women, and umbilical cords. Metod. Measurement of total titers of anti-Bordetella spp. (Bordetella) antibodies using an enzyme-linked immunosorbent assay. Serum samples from 103 donors, 101 post-partum women and 100 umbilical cords were analyzed. Titers <80 were considered of low impact against the disease. The assessment included transplacental transfer of antibodies and the umbilical cord/maternal ratio of antibody titers. Results. Donors mean age was: 28 ± 6 years old. Mediananti-Bordetella titers: 320; interquartile range (IQR):160-320; 10% had titers <80. Post-partum women mean age was: 26 ± 6 years old. Median anti-Bordetella titers:160 (IQR:80-320), with titers significantly lower than in female donors (p= 0.00002). Titers <80 were found in 30% of post-partum women. Median anti-Bordetella titers in umbilical cords: 160 (IQR: 80-160). Titers <80 were more frequently found in umbilical cords than in mothers (44% versus 30%, p= 0.04). Transplacental transfer was 0.83. Umbilical cord titers were equal to maternal titers in 54% of cases, lower in 37%, and higher only in 8%. Conclusion. Titers of anti-Bordetella antibodies in post-partum women were significantly lower than in female blood donors. Titers <80 were found in 30% of post-partum women and 44% of umbilical cords. These data may account for the high rates of pertussis in young infants who have not yet completed their vaccination schedule.

  19. Hexachlorocyclohexanes (HCHs) in placenta and umbilical cord blood and dietary intake for women in Beijing, China

    International Nuclear Information System (INIS)

    Placenta and umbilical cord blood are important media for investigating maternal–fetal exposure to environmental pollutants. Historically hexachlorocyclohexanes (HCHs) were once widely-used in China. In this study, residues of HCHs were measured in placenta and umbilical cord blood samples for 40 women from Beijing. The measured median values of HCHs were 62.0 and 68.8 ng/g fat in placenta and umbilical cord blood, respectively. Concentrations of HCHs in placenta and umbilical cord blood of urban cohort were higher than those of rural group due to enhanced consumption of fish, meat, and milk. Residues of HCHs in placenta were significantly correlated with total food consumption, dietary intake, and maternal age, and could be predicted using the parameters dependent upon ingestion of meat and milk. The transplacental exposure of fetuses to HCHs was revealed by a close association between the residual levels in the paired placenta and the paired umbilical cord blood samples. -- Highlights: •Medians of HCH in placenta and umbilical cord blood of 40 puerperal women from Beijing were 62.0 and 68.8 ng/g⋅fat. •HCHs in placenta and umbilical cord blood of urban cohort were higher than those of rural one. •HCH residues in placenta were significantly correlated with total food consumption, daily dietary intake, and maternal age. •The transplacental exposure of fetus to HCHs was revealed. -- HCHs in placenta of women in Beijing were significantly correlated with total food consumption, dietary intake, and maternal age

  20. Genetica Humana

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2015-02-01

    Full Text Available Sometimes we do not realize that Spanish speaking people are one of the major linguistic group on our planet! Thus we have to welcome this excellent book devoted to, as the title clearly tell us, human genetics for the pleasure of the Spanish speaking people. Those who love genetics, young fellows at the beginning of their careers, esteemed professors and historians of science will get for the affordable price.....

  1. Efectos para Colombia de los debates en torno a la seguridad del Estado y a la seguridad humana

    Directory of Open Access Journals (Sweden)

    Diana Mejía Molina

    2009-06-01

    Full Text Available Desde la última década del siglo xx ha tomado fuerza el concepto de seguridad humana como alternativa a la idea clásica de seguridad estatal, con lo cual se ha intentado darle mayor consideración a la obligación de los Estados de hacer respetar los derechos humanos dentro de su territorio. Sin embargo, tras el 11 de septiembre de 2001 la seguridad estatal ha vuelto a tomar protagonismo, sin que esto signifique la desaparición política de la seguridad humana. Este artículo explora el significado de estos dos conceptos y plantea una reflexión sobre la importancia actual de la idea de seguridad humana para Colombia.

  2. Studies on Catheterization of Fetal Arteria Mbilicalis Uterus of Pregant Sheep%妊娠山羊宫内胎儿脐动脉插管手术方法的研究

    Institute of Scientific and Technical Information of China (English)

    谭聪; 杨淑华; 何剑斌

    2014-01-01

    为了优化山羊胎儿脐动脉插管模型,本试验采用医用硬膜外导管对单胎妊娠120日龄的山羊进行胎儿脐动脉插管手术,对其手术途径、导管类型、插管方法、麻醉和术后护理进行研究。术后可顺利采集胎儿血液样本,1周后母山羊正常分娩。本试验建立的山羊胎儿脐动脉插管模型的手术方案,可为胎儿疾病的诊断及临床用药等提供试验基础。%In order to optimize the model of catheterization in goat fetal umbilical artery,medi-cal epidural catheter was used on the 120 days age single pregnant goats fetal umbilical artery. The surgical approach, types of catheter, anesthesia and postoperative care were investigated. Blood samples were successfully collected after surgery and one week later stepmother goat could normally be delivered.Surgical options of goats umbilical artery model was established in this test to provides an experimental basis for the diagnosis and clinical treatment of diseases such as fetal.

  3. Gestão Ambiental nas Organizações Humanas

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    Jefferson de Queiroz Crispim

    2003-05-01

    Full Text Available Este artigo pretende abordar os conceitos e aplicabilidade da Gestão Ambiental nas Organizações Humanas. Parte de algumas premissas teóricas de interdisciplinaridade que fundamentam as ciências da administração, da economia e da pedagogia humana nas empresas, que possibilitam a ação eficaz na rede sistêmica da vida organizacional. Sabe-se, que a construção do conhecimento organizacional fundamenta-se na própria reconstrução do conhecimento, onde a interdisciplinaridade das Ciências Naturais e Socais é condição “sine qua mon”, para que este entendimento se fortaleça, quando dirigida para a aplicabilidade coletiva das vidas das empresas. Serão analisados os aspectos relacionados com origem do movimento capitalista, as estratégias de organização e a relação com a natureza, bem como a organização social e reconstrução das relações sócias entre empresas, sociedade e mercado.

  4. Sexualidade humana na formação do enfermeiro Sexualidad humana en la formación del enfermero Human sexuality in nurses' formation

    Directory of Open Access Journals (Sweden)

    Elucir Gir

    2000-04-01

    Full Text Available Aplicou-se um questionário aos alunos do curso de graduação em Enfermagem, com o objetivo de se verificar as noções que estes sujeitos apresentam acerca da temática sexualidade, no término do curso de graduação, bem como identificar alguns temas da sexualidade vivenciados por ocasião de suas atividades acadêmicas. Os resultados mostraram que os alunos apresentam, em sua maioria, noções fluídas e limitadas, sem embasamento norteador sobre sexualidade humana, além de empregarem os termos "sexo" e "sexualidade" como sinônimos. Os alunos referem ter necessidade de adquirir conhecimento sobre sexualidade. Apresenta-se, ainda, a classificação do embasamento recebido, as disciplinas do curso de graduação que viabilizaram discussões e as situações-tema enfrentadas ou abordadas nas atividades acadêmicas.Se aplicó un cuestionario a los alumnos del curso de pre-grado en enfermería, en el término del mismo, con el objetivo de verificar las acciones que estos sujetos presentan acerca de la temática de sexualidad, y también identificar algunos temas de la sexualidad vividos en sus actividades académicas. Los resultados demostraron que los alumnos presentan, en su mayoría, nociones fluidas y limitadas, sin una base de orientación sobre la sexualidad humana, además de usar el término "sexo" y "sexualidad" como sinónimos. Los alumnos refieren necesidad en adquirir conocimientos sobre sexualidad. Se presenta, además, la clasificación del conocimiento previo recibido, las asignaturas del curso de pre-grado que permitieron discusiones y las situaciones-tema enfrentadas y/o abordadas en las actividades académicas.A questionnaire was applied to undergraduate nursing students in order to verify the ideas on the sexuality theme they had absorbed from the notions they received in their nursing undergraduate program. Results showed that most of these students have slightly, limited and unbased notions concerning human sexuality. They

  5. La deshumanización del hombre. Reflexiones de leon R. Kass sobre la clonación humana

    OpenAIRE

    Aída María Ponce del Castillo

    2006-01-01

    El incesante desarrollo de la ingeniería genética en el ámbito mundial genera profundos cuestionamientos éticos, legales y sociales por las consecuencias que estas investigaciones pueden tener tanto en los individuos en lo particular, como en el futuro de la especie humana en general. El experto en bioética Leon R. Kass ha realizado un profundo estudio de los alcances de esas experimentaciones, y particularmente con respecto a la clonación humana, advirtiendo situaciones comple...

  6. "La persona humana como relación en el orden del origen" [Reseña

    OpenAIRE

    Alonso-Bastarreche, G. (Gonzalo)

    2011-01-01

    Reseña de Leonardo Polo, “La persona humana como relación en el orden del origen”. Miscelánea poliana 30 (2010) 28-41. Se trata de un artículo, hasta el momento inédito, fechado en 1980. “La unidad en Hegel”, en FALGUERAS-GARCÍA-PADIAL(edits.): Yo y tiempo. La antropología filosófica de Hegel, v. I: "La sustancialidad y subjetividad humanas", Contrastes, 15-1, Málaga, 2010, 147-64.

  7. La vida humana como principio interpretativo radical en la filosofía de Ortega y Gasset

    OpenAIRE

    Antonio Gutiérrez-Pozo

    2012-01-01

    En este artículo presentamos el concepto de vida humana como texto eterno en el pensamiento de Ortega y sus consecuencias para el problema de la interpretación. La filosofía de la razón vital de Ortega se fundamenta en el concepto de vida humana como realidad radical y principio interpretativo universal, y por esta razón se presenta desde el principio como una filosofía hermenéutica de la vida y no como una reducción hacia la conciencia trascendental. Esta hermenéutica se practica especialmen...

  8. Hallazgo de impresiones de uñas humanas en un fragmento de cerámica aborigen de Cuba

    Directory of Open Access Journals (Sweden)

    Manuel F. Rivero de la Calle

    2008-11-01

    Full Text Available Se da a conocer un conjunto de impresiones de uñas humanas, las que aparecen en la cara externa del fondo de una cazuela aborigen recuperada en el sitio arqueológico agroalfarero Toma de Agua, municipio La Sierpe, provincia Sancti Spíritus. En la cara interna del ejemplar se descubre también dos pequeños trazos que se identifican así mismo como correspondientes a uñas humanas.

  9. Escuela de las Relaciones Humanas en la Administración: antecedentes = School of Human Relations in Administration: background

    OpenAIRE

    Rendón Giraldo, Lina María

    2011-01-01

    La Escuela de Relaciones Humanas en Administración surgió al final de la década de 1920 en Estados Unidos, formalizada a partir de los estudios Hawthorne de Elton Mayo. El presente texto tiene como objetivo identificar y documentar los antecedentes de la Escuela de Relaciones Humanas en Administración hasta finales de la década de 1920 que constituyen anticipaciones a los planteamientos de Elton Mayo. La búsqueda se centra en los aspectos humanistas en el trabajo en diferentes épocas históric...

  10. La percepción medioambiental del profesorado de primaria en el tema de la nutrición humana

    OpenAIRE

    García-Barros, Susana; Martínez Losada, Cristina; Rivadulla-López, Juan Carlos

    2010-01-01

    En este trabajo se muestra como un proyecto de tesis doctoral, dirigido a estudiar el pensamiento del profesorado de educación primaria en ejercicio y en formación sobre la nutrición humana, se acerca a la problemática ambiental. En el artículo se justifica la dimensión medioambiental de la nutrición humana que sirve de referencia para las decisiones tomadas en la metodología planteada. Así mismo se presentan unos primeros resultados, que aunque todavía limitados, ponen de manifiesto que l...

  11. In Vitro Vasoactive Effects of Levobupivacaine and Ropivacaine on the Isolated Human Umbilical Artery and Vein

    Directory of Open Access Journals (Sweden)

    Alper Kılıçaslan

    2011-06-01

    Full Text Available Objective: In this in vitro study, we investigated the vasoactive effects of levobupivacaine and ropivacaine on vascular smooth muscle derived from human umbilical arteries and veins.Material and Methods: The strips were mounted in tissue baths at 37°C continuously gassed with 5% CO2 in oxygen for isometric recording of contractile activity on a polygraph. The endothelium of some tissues was mechanically removed to assess the influence of the endothelium on contractility. The strips were precontracted with serotonin (10-6 M 5-HT; n=7. After obtaining the maximal contraction, responses obtained by adding levobupivacaine and ropivacaine (10-9-10-4 M; n=7 cumulatively were recorded. Contractions were expressed as the (% of 5HT maximal response percentage of 5 HT’s maximal response.Results: Both levobupivacaine and ropivacaine induce a concentration-dependent contraction in the smooth muscle cells of umbilical arteries and veins. Maximum contractile response (Emax of levobupivacaine (79.2±2.5, 71.1±2.6 was higher than ropivacaine (68.4±2, 36.2±2.8 on both umbilical arteries and veins. There were no statistically significant differences between contraction responses of endothelium-intact and endothelium-denuded tissues. Conclusion: The results suggest that, in high concentrations, levobupivacaine and ropivacaine may affect umbilical blood flow by contracting the umbilical artery and vein, thus reducing fetal blood flow.

  12. Umbilical hernia rupture with evisceration of omentum from massive ascites: a case report

    LENUS (Irish Health Repository)

    Good, Daniel W

    2011-05-03

    Abstract Introduction The incidence of hernias is increased in patients with alcoholic liver disease with ascites. To the best of our knowledge, this is the first report of an acute rise in intra-abdominal pressure from straining for stool as the cause of a ruptured umbilical hernia. Case presentation An 81-year-old Caucasian man with a history of alcoholic liver disease presented to our emergency department with an erythematous umbilical hernia and clear, yellow discharge from the umbilicus. On straining for stool, after initial clinical assessment, our patient noted a gush of fluid and evisceration of omentum from the umbilical hernia. An urgent laparotomy was performed with excision of the umbilicus and devitalized omentum. Conclusion We report the case of a patient with a history of alcoholic liver disease with ascites. Ascites causes a chronic increase in intra-abdominal pressure. A sudden increase in intra-abdominal pressure, such as coughing, vomiting, gastroscopy or, as in this case, straining for stool can cause rupture of an umbilical hernia. The presence of discoloration, ulceration or a rapid increase in size of the umbilical hernia signals impending rupture and should prompt the physician to reduce the intra-abdominal pressure.

  13. Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Eder Zucconi

    2011-01-01

    Full Text Available Umbilical cord mesenchymal stromal cells (MSC have been widely investigated for cell-based therapy studies as an alternative source to bone marrow transplantation. Umbilical cord tissue is a rich source of MSCs with potential to derivate at least muscle, cartilage, fat, and bone cells in vitro. The possibility to replace the defective muscle cells using cell therapy is a promising approach for the treatment of progressive muscular dystrophies (PMDs, independently of the specific gene mutation. Therefore, preclinical studies in different models of muscular dystrophies are of utmost importance. The main objective of the present study is to evaluate if umbilical cord MSCs have the potential to reach and differentiate into muscle cells in vivo in two animal models of PMDs. In order to address this question we injected (1 human umbilical cord tissue (hUCT MSCs into the caudal vein of SJL mice; (2 hUCT and canine umbilical cord vein (cUCV MSCs intra-arterially in GRMD dogs. Our results here reported support the safety of the procedure and indicate that the injected cells could engraft in the host muscle in both animal models but could not differentiate into muscle cells. These observations may provide important information aiming future therapy for muscular dystrophies.

  14. Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy

    Science.gov (United States)

    Zucconi, Eder; Vieira, Natassia Moreira; Bueno, Carlos Roberto; Secco, Mariane; Jazedje, Tatiana; Costa Valadares, Marcos; Fussae Suzuki, Miriam; Bartolini, Paolo; Vainzof, Mariz; Zatz, Mayana

    2011-01-01

    Umbilical cord mesenchymal stromal cells (MSC) have been widely investigated for cell-based therapy studies as an alternative source to bone marrow transplantation. Umbilical cord tissue is a rich source of MSCs with potential to derivate at least muscle, cartilage, fat, and bone cells in vitro. The possibility to replace the defective muscle cells using cell therapy is a promising approach for the treatment of progressive muscular dystrophies (PMDs), independently of the specific gene mutation. Therefore, preclinical studies in different models of muscular dystrophies are of utmost importance. The main objective of the present study is to evaluate if umbilical cord MSCs have the potential to reach and differentiate into muscle cells in vivo in two animal models of PMDs. In order to address this question we injected (1) human umbilical cord tissue (hUCT) MSCs into the caudal vein of SJL mice; (2) hUCT and canine umbilical cord vein (cUCV) MSCs intra-arterially in GRMD dogs. Our results here reported support the safety of the procedure and indicate that the injected cells could engraft in the host muscle in both animal models but could not differentiate into muscle cells. These observations may provide important information aiming future therapy for muscular dystrophies. PMID:21785565

  15. CORRELATION OF UMBILICAL CORD THICKNESS WITH FETAL BIRTH WEIGHT - A PROSPECTIVE STUDY IN RURAL BENGAL

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    Monojit

    2015-09-01

    Full Text Available AIMS: Aim of our study in this area of Bengal to assess the correlation of ultrasonic measurements of umbilical cord thickness in between 20 – 30 weeks with low birth weight babies. Materials and methods: The prospective stud y was done from March 2014 to December 2014 among 150 pregnant women who were referred for routine USG after 20 weeks of gestation. 139 met the criteria fixed by us. In these patients the diameter of cord were measured in a free loop of umbilical cord. The pregnancies were followed till delivery when birth weights of the babies were recorded. RESULTS: Correlation between lean umbilical cord and low birth weight were statistically observed with sensitivity of 55.5%, specificity of 94.3%, and positive predict ive value of 68.18% and negative predictive value of 90% and were significant. Correlation also noted lean umbilical cord with low birth weight (P 0.01. CONCLUSION: Umbilical cord thickness by USG after 20 weeks are helpful to asses low birth weight and t hus the important denominator for adverse pregnancy results.

  16. Umbilical Coiling Index as a Marker of Perinatal Outcome: An Analytical Study

    Directory of Open Access Journals (Sweden)

    T. Chitra

    2012-01-01

    Full Text Available Objectives. To measure umbilical coiling index (UCI postnatally and to study the association of normocoiling, hypocoiling and hypercoiling to maternal and perinatal outcome. Method(s. One thousand antenatal women who went into labour were studied and umbilical coiling index calculated at the time of delivery. UCI was determined by dividing the total number of coils by the total umbilical cord length in centimeters. Its association with various maternal and perinatal risk factors were noted. The statistical tests were the Chi-square test and assessed with SPSS version 13.0 software and statistically analyzed. P value of less than 0.05 was regarded as statistically significant. Results. The mean umbilical coiling index was found to be 0.24 ± 0.09. Hypocoiling (0.36 was found to be associated with diabetes mellitus, polyhydramnios, cesarean delivery, congenital anomalies, and respiratory distress of the newborn. Conclusion. Abnormal umbilical coiling index is associated with several antenatal and perinatal adverse features.

  17. In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells

    International Nuclear Information System (INIS)

    Cardiomyocyte loss in the ischemically injured human heart often leads to irreversible defects in cardiac function. Recently, cellular cardiomyoplasty with mesenchymal stem cells, which are multipotent cells with the ability to differentiate into specialized cells under appropriate stimuli, has emerged as a new approach for repairing damaged myocardium. In the present study, the potential of human umbilical cord-derived mesenchymal stem cells to differentiate into cells with characteristics of cardiomyocyte was investigated. Mesenchymal stem cells were isolated from endothelial/subendothelial layers of the human umbilical cords using a method similar to that of human umbilical vein endothelial cell isolation. Isolated cells were characterized by transdifferentiation ability to adipocytes and osteoblasts, and also with flow cytometry analysis. After treatment with 5-azacytidine, the human umbilical cord-derived mesenchymal stem cells were morphologically transformed into cardiomyocyte-like cells and expressed cardiac differentiation markers. During the differentiation, cells were monitored by a phase contrast microscope and their morphological changes were demonstrated. Immunostaining of the differentiated cells for sarcomeric myosin (MF20), desmin, cardiac troponin I, and sarcomeric α-actinin was positive. RT-PCR analysis showed that these differentiated cells express cardiac-specific genes. Transmission electron microscopy revealed a cardiomyocyte-like ultrastructure and typical sarcomers. These observations confirm that human umbilical cord-derived mesenchymal stem cells can be chemically transformed into cardiomyocytes and can be considered as a source of cells for cellular cardiomyoplasty

  18. Umbilical cord blood banks. Ethical aspects. Public versus private banks.

    Science.gov (United States)

    Aznar Lucea, Justo

    2012-01-01

    The creation of umbilical cord blood (UCB) banks raises interesting medical, social, economic and ethical issues. This paper reviews the ethical problems specifically. In this respect, it evaluates: a) whether there are advantages to the use of UCB compared to bone marrow, b) whether or not it is ethical to create UCB banks, c) whether their creation is ethically acceptable in terms of their clinical usefulness or d) the use made of them for therapeutic purposes, and finally e) whether their creation is ethically justified from a cost/profitability point of view. We focus primarily on evaluating the ethical controversy between public and private banks, particularly on whether it is ethical to bank autologous blood in private UCB banks, on the basis of its limited possibilities for use by the cord blood donor. We can conclude that, from an ethical point of view, autologous blood banks have limited acceptance among specialised researchers, scientific societies and other public institutions. Therefore, we believe that it is ethically more acceptable to support the creation of public UCB banks for medical and social reasons and, above all, based on the principle of justice and human solidarity. Nevertheless, there is no definitive ethical argument why a couple, according to their autonomy and freedom, cannot bank their child's UCB in a private bank. An equally acceptable solution could be the creation of mixed banks, such as that proposed by the Virgin Health Bank or like the Spanish system where autologous samples can be stored in public banks but with the proviso that if at any time the stored sample is required by any person other than the donor, it would have to be given to them. PMID:23130743

  19. UMBILICAL CORD BLOOD BANKS. ETHICAL ASPECTS. PUBLIC VERSUS PRIVATE BANKS

    Directory of Open Access Journals (Sweden)

    Justo Aznar Lucea

    2012-01-01

    Full Text Available The creation of umbilical cord blood (UCB banks raises interesting medical, social, economic and ethical issues. This paper reviews the ethical problems specifically. In this respect, it evaluates: a whether there are advantages to the use of UCB compared to bone marrow, b whether or not it is ethical to create UCB banks, c whether their creation is ethically acceptable in terms of their clinical usefulness or d the use made of them for therapeutic purposes, and finally e whether their creation is ethically justified from a cost/profitability point of view. We focus primarily on evaluating the ethical controversy between public and private banks, particularly on whether it is ethical to bank autologous blood in private UCB banks, on the basis of its limited possibilities for use by the cord blood donor. We can conclude that, from an ethical point of view, autologous blood banks have limited acceptance among specialised researchers, scientific societies and other public institutions. Therefore, we believe that it is ethically more acceptable to support the creation of public UCB banks for medical and social reasons and, above all, based on the principle of justice and human solidarity. Nevertheless, there is no definitive ethical argument why a couple, according to their autonomy and freedom, cannot bank their child's UCB in a private bank. An equally acceptable solution could be the creation of mixed banks, such as that proposed by the Virgin Health Bank or like the Spanish system where autologous samples can be stored in public banks but with the proviso that if at any time the stored sample is required by any person other than the donor, it would have to be given to them.

  20. Isolation of mesenchymal stem cells from equine umbilical cord blood

    Directory of Open Access Journals (Sweden)

    Thomsen Preben D

    2007-05-01

    Full Text Available Abstract Background There are no published studies on stem cells from equine cord blood although commercial storage of equine cord blood for future autologous stem cell transplantations is available. Mesenchymal stem cells (MSC have been isolated from fresh umbilical cord blood of humans collected non-invasively at the time of birth and from sheep cord blood collected invasively by a surgical intrauterine approach. Mesenchymal stem cells isolation percentage from frozen-thawed human cord blood is low and the future isolation percentage of MSCs from cryopreserved equine cord blood is therefore expectedly low. The hypothesis of this study was that equine MSCs could be isolated from fresh whole equine cord blood. Results Cord blood was collected from 7 foals immediately after foaling. The mononuclear cell fraction was isolated by Ficoll density centrifugation and cultured in a DMEM low glucose based media at 38.5°C in humidified atmosphere containing 5% CO2. In 4 out of 7 samples colonies with MSC morphology were observed. Cellular morphology varied between monolayers of elongated spindle-shaped cells to layered cell clusters of cuboidal cells with shorter cytoplasmic extensions. Positive Alizarin Red and von Kossa staining as well as significant calcium deposition and alkaline phosphatase activity confirmed osteogenesis. Histology and positive Safranin O staining of matrix glycosaminoglycans illustrated chondrogenesis. Oil Red O staining of lipid droplets confirmed adipogenesis. Conclusion We here report, for the first time, the isolation of mesenchymal-like stem cells from fresh equine cord blood and their differentiation into osteocytes, chondrocytes and adipocytes. This novel isolation of equine cord blood MSCs and their preliminary in vitro differentiation positions the horse as the ideal pre-clinical animal model for proof-of-principle studies of cord blood derived MSCs.

  1. Ansiedade e impaciência: cânceres sociais na Educação e Relações Humanas

    Directory of Open Access Journals (Sweden)

    Antonio Mendes Silva Filho

    2016-02-01

    Full Text Available Os hábitos dizem muito da natureza humana e podem ajudar ou dificultar a formação humana. Aristóteles nos ensina a entender a natureza humana quando diz que “somos aquilo que fazemos repetidamente”. Hábitos consistem de padrões comportamentais realizados costumeiramente, frutos da frequente repetição de atos. Portanto, hábitos constituem traços que seres humanos podem desenvolver ao longo da vida. Os hábitos ajudam a compreender a natureza humana, pois eles os acompanham ao longo da vida como virtudes ou defeitos. Mas, a virtude torna-se em vício se mal aplicada. Este artigo explora e discute hábitos, cânceres sociais, que têm afetado a educação e relações humanas

  2. Abnormal systemic venous connection possibly associated with a persistent right umbilical vein; a case report

    Directory of Open Access Journals (Sweden)

    Smevik Bjarne

    2004-04-01

    Full Text Available Abstract Background Abnormal venous connections involving a persistent right umbilical vein are rare. In a minority of cases the liver is entirely bypassed and the condition is associated with multiple congenital malformations. Case presentation The described case illustrates a systemic venous drainage that was severely abnormal in a newborn girl with a truncus arteriosus type II congenital heart defect. Injection of contrast medium through the umbilical vein catheter revealed a very peculiar venous connection that passed anterio-laterally through the right hemithorax before crossing in an oblique fashion towards the superior vena cava. Conclusions This venous drainage may be the result of a persistent right umbilical vein connecting with the superior vena cava.

  3. Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy

    Institute of Scientific and Technical Information of China (English)

    Xiaofeng Yang; Yanxiang Wu; Xinping Liu; Yifeng Xu; Naiwu Lü; Yibin Zhang; Hongmei Wang; Xin Lü; Jiping Cui; Jinxu Zhou; Hong Shan

    2011-01-01

    Due to their relative abundance, stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy, which is a muscular atrophy disease. Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion, in combination with multi-point intramuscular injection. They were followed up for 12 months after cell transplantation. Results showed that clinical symptoms significantly improved, daily living activity and muscle strength were enhanced,the sero-enzyme, electromyogram, and MRI scans showed improvement, and dystrophin was expressed in the muscle cell membrane. Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged, fibrous degeneration was alleviated, and fat infiltration was improved. These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.

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  15. Human umbilical cord Wharton's jelly-derived oligodendrocyte precursor-like cells for axon and myelin sheath regeneration★

    OpenAIRE

    Chen, Hong; Zhang, Yan; Yang, Zhijun; Zhang, Hongtian

    2013-01-01

    Human umbilical mesenchymal stem cells from Wharton's jelly of the umbilical cord were induced to differentiate into oligodendrocyte precursor-like cells in vitro. Oligodendrocyte precursor cells were transplanted into contused rat spinal cords. Immunofluorescence double staining indicated that transplanted cells survived in injured spinal cord, and differentiated into mature and immature oligodendrocyte precursor cells. Biotinylated dextran amine tracing results showed that cell transplantat...

  16. Evaluation of three high abundance protein depletion kits for umbilical cord serum proteomics

    Directory of Open Access Journals (Sweden)

    Nie Jing

    2011-05-01

    Full Text Available Abstract Background High abundance protein depletion is a major challenge in the study of serum/plasma proteomics. Prior to this study, most commercially available kits for depletion of highly abundant proteins had only been tested and evaluated in adult serum/plasma, while the depletion efficiency on umbilical cord serum/plasma had not been clarified. Structural differences between some adult and fetal proteins (such as albumin make it likely that depletion approaches for adult and umbilical cord serum/plasma will be variable. Therefore, the primary purposes of the present study are to investigate the efficiencies of several commonly-used commercial kits during high abundance protein depletion from umbilical cord serum and to determine which kit yields the most effective and reproducible results for further proteomics research on umbilical cord serum. Results The immunoaffinity based kits (PROTIA-Sigma and 5185-Agilent displayed higher depletion efficiency than the immobilized dye based kit (PROTBA-Sigma in umbilical cord serum samples. Both the PROTIA-Sigma and 5185-Agilent kit maintained high depletion efficiency when used three consecutive times. Depletion by the PROTIA-Sigma Kit improved 2DE gel quality by reducing smeared bands produced by the presence of high abundance proteins and increasing the intensity of other protein spots. During image analysis using the identical detection parameters, 411 ± 18 spots were detected in crude serum gels, while 757 ± 43 spots were detected in depleted serum gels. Eight spots unique to depleted serum gels were identified by MALDI- TOF/TOF MS, seven of which were low abundance proteins. Conclusions The immunoaffinity based kits exceeded the immobilized dye based kit in high abundance protein depletion of umbilical cord serum samples and dramatically improved 2DE gel quality for detection of trace biomarkers.

  17. A Comparative Study of Blood Culture Sampling from Umbilical Catheter Line versus Peripheral Site

    Directory of Open Access Journals (Sweden)

    Abdolkarim Hamedi

    2010-08-01

    Full Text Available Neonatal sepsis is an important cause of death and morbidity in newborns and is diagnosed by isolation of organism in blood culture. In several reports,reliablity of blood cultures were done from umbi lical catheters,have been demonstrated. The objective of the present study was to determine,wether an inde welling umbilical catheter, could be an alternative site for blood culture. In a prospective study over 6 months during 2006,141 paired blood cultures from 134 infant,were done simultaneously from peripheral site and umbilical catheter (mostly U. V. C,during the first four days of life. Majority of these infants were preterm and admitted to NICU for special care. these infants had indwelling umbilical line and had indication of sepsis workup. A total of 141 pairs of blood cultures were obtained from 134 infants. In 16 infants blood culture pairs were positive for one organism in both peripheral vein and umbilical site. 71. 6% of total cultures (n=11pairs were negative in boths site. A total of 22 pairs were positive in one site only,with 5 positive from peripheral vein only and the other 17 from umblical site. Two pairs were positve in boths site with two different organism. In over all 16 infant (11%of blood were considered to be contaminated. Contamination rate were 2. 4% and 9. 2% for peripheral and umbilical catheter site. Contamination rate increased after 48 hours of age in umbilical catheter. The result showed that after 2 days contamination rate for blood culture taken from catheter line increased and specifity decreased. We recommended that blood culture via umblical catheter in first 2 days in sick neonates with indwelling catheter can be a alternate site of blood culture sampelling.

  18. Aflatoxinas e ocratoxina A em alimentos e riscos para a saúde humana

    Directory of Open Access Journals (Sweden)

    Eloisa Dutra Caldas

    2002-06-01

    Full Text Available OBJETIVOS: A presença de micotoxinas em alimentos tem sido correlacionada a várias patologias humanas, e as autoridades de saúde no mundo todo têm implementado ações para diminuir a ingestão desses compostos pela dieta. Realizou-se pesquisa para analisar os níveis de aflatoxinas e ocratoxina A de alimentos para consumo e avaliar o potencial de risco da exposição humana a essas micotoxinas. MÉTODOS: Foram analisadas 366 amostras de alimentos consumidos no Distrito Federal, no período de julho de 1998 a dezembro de 2001, como amendoim e derivados, castanhas, milho, produtos de trigo e/ou aveia, arroz e feijão. As amostras foram processadas, e as micotoxinas extraídas, detectadas e quantificadas por fluorescência após separação em cromatografia camada delgada. RESULTADOS: Foram detectadas aflatoxinas em 19,6% das amostras, em amendoim cru e derivados, milho de pipoca, milho em grão e castanha-do-pará (>2 mig/kg. Amendoim e derivados apresentaram maior incidência de contaminação por aflatoxinas (34,7% com amostras contendo até 1.280 mig/kg de AFB1+AFG1 e 1.706 mig/kg de aflatoxinas totais. Das amostras positivas, AFB1 estava presente em 98,5%, AFB2 em 93%, AFG1 em 66,7% e AFG2 em 65,4%. A ocratoxina A não foi detectada (<25 mig/kg em nenhuma amostra analisada. CONCLUSÃO: Os níveis de contaminação encontrados em amendoim e derivados ultrapassaram os níveis máximos permitidos pela legislação brasileira, podendo significar fator de risco para a população que os consome regularmente. A conscientização dos produtores de alimentos e as ações de vigilância sanitária permanentes são essenciais para diminuir a exposição humana a esses compostos e prevenir doenças crônicas advindas dessa exposição.

  19. Aflatoxinas e ocratoxina A em alimentos e riscos para a saúde humana

    Directory of Open Access Journals (Sweden)

    Caldas Eloisa Dutra

    2002-01-01

    Full Text Available OBJETIVOS: A presença de micotoxinas em alimentos tem sido correlacionada a várias patologias humanas, e as autoridades de saúde no mundo todo têm implementado ações para diminuir a ingestão desses compostos pela dieta. Realizou-se pesquisa para analisar os níveis de aflatoxinas e ocratoxina A de alimentos para consumo e avaliar o potencial de risco da exposição humana a essas micotoxinas. MÉTODOS: Foram analisadas 366 amostras de alimentos consumidos no Distrito Federal, no período de julho de 1998 a dezembro de 2001, como amendoim e derivados, castanhas, milho, produtos de trigo e/ou aveia, arroz e feijão. As amostras foram processadas, e as micotoxinas extraídas, detectadas e quantificadas por fluorescência após separação em cromatografia camada delgada. RESULTADOS: Foram detectadas aflatoxinas em 19,6% das amostras, em amendoim cru e derivados, milho de pipoca, milho em grão e castanha-do-pará (>2 mig/kg. Amendoim e derivados apresentaram maior incidência de contaminação por aflatoxinas (34,7% com amostras contendo até 1.280 mig/kg de AFB1+AFG1 e 1.706 mig/kg de aflatoxinas totais. Das amostras positivas, AFB1 estava presente em 98,5%, AFB2 em 93%, AFG1 em 66,7% e AFG2 em 65,4%. A ocratoxina A não foi detectada (<25 mig/kg em nenhuma amostra analisada. CONCLUSÃO: Os níveis de contaminação encontrados em amendoim e derivados ultrapassaram os níveis máximos permitidos pela legislação brasileira, podendo significar fator de risco para a população que os consome regularmente. A conscientização dos produtores de alimentos e as ações de vigilância sanitária permanentes são essenciais para diminuir a exposição humana a esses compostos e prevenir doenças crônicas advindas dessa exposição.

  20. High-mobility group box-1 release into fetal circulation from umbilical cord tissue and amniotic epithelium in fetal ischemia.

    Science.gov (United States)

    Nakamura, Toshihiko; Yoshioka, Toshirou; Yamada, Shingo; Miyasho, Taku; Sakakibara, Nana; Hatanaka, Daishuke

    2016-07-01

    We report the case of a baby with low birthweight born by emergency caesarean section at 33 weeks 2 days' gestation due to placental abruption. High-mobility group box-1 (HMGB-1) and interleukin-17 concentration in the umbilical cord blood were high at 55.7 ng/mL and 50.7 pg/mL, respectively. On immunostaining of umbilical cord and amniotic epithelium, HMGB-1 was identified in the nuclei of vascular endothelial cells and cytoplasm of the surrounding cells in the umbilical cord. This suggests that, in the present case of placental abruption and subsequent ischemic placenta and fetus, the high level of HMGB-1 observed was due to the release of HMGB-1 into the umbilical cord blood from the vascular endothelial cells of the umbilical cord. PMID:27097754

  1. Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed

    Directory of Open Access Journals (Sweden)

    Rahul Gupta

    2016-05-01

    Full Text Available The foreign body ingestion is a rare cause of gastrointestinal perforation in children and is typically seen with sharp foreign bodies or button batteries. Herein, we report an 11-month old male baby who presented with obstructed umbilical hernia. Abdominal radiograph showed dilated small bowel loops, while ultrasonography and CT scan suggested presence of a foreign body. Laparotomy revealed obstructed umbilical hernia with a plum seed being stuck in the terminal ileum causing intestinal perforation. Resection and anastomosis of intestine was performed.

  2. Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed

    Science.gov (United States)

    Mujalde, Vikram Singh; Gupta, Shilpi; Gupta, Pradeep Kumar; Bhandari, Anu; Mathur, Praveen

    2016-01-01

    The foreign body ingestion is a rare cause of gastrointestinal perforation in children and is typically seen with sharp foreign bodies or button batteries. Herein, we report an 11-month old male baby who presented with obstructed umbilical hernia. Abdominal radiograph showed dilated small bowel loops, while ultrasonography and CT scan suggested presence of a foreign body. Laparotomy revealed obstructed umbilical hernia with a plum seed being stuck in the terminal ileum causing intestinal perforation. Resection and anastomosis of intestine was performed. PMID:27398326

  3. Viscoelastic evaluation of fetal umbilical vein for reconstruction of middle cerebral artery

    OpenAIRE

    Li, Dongyuan; Xu, Donghui; Li, Peng; Wei, Jun; Yang, Kun; Zhao, Conghai

    2013-01-01

    The transplantation of artificial blood vessels with < 6 mm inner diameter as substitutes for human arterioles or veins has not achieved satisfactory results. Umbilical vein has been substituted for ar-tery in vascular transplantation, but it remains unclear whether the stress relaxation and creep tween these vessels are consistent. In this study, we used the fetal umbilical vein and middle cere-bral artery from adult male cadavers to make specimens 15 mm in length, 0.196–0.268 mm in nica med...

  4. Characterization of Adherent Nonhematopoietic Cells Derived from Human Umbilical Cord Blood

    Institute of Scientific and Technical Information of China (English)

    安小惠; 蔡国平

    2003-01-01

    To confirm and characterize the adherent fibroblast-like progenitors in human umbilical cord blood, we isolated mononuclear cells from human umbilical cord blood by Ficoll-Hypaque.Two main morphologically different kinds of cells were formed by culturing the cells in collagen-coated 24-well plastic dishes and flasks.One type was the adherent fibroblast-like cells, while the other was loosely adherent clonally expanded round cells.Our experiments demonstrate that the adherent fibroblast-like cells possess multilineage potential, including the ability to differentiate into endothelial-like cells and to express the mesenchymal cell marker.

  5. Effect of syncytiotrophoblast microvillous membrane treatment on gene expression in human umbilical vein endothelial cells

    DEFF Research Database (Denmark)

    Høgh, Mette; Tannetta, D; Sargent, I;

    2006-01-01

    directly causes the endothelial cell dysfunction of pre-eclampsia. This study investigates the effect of STBM on endothelial cell gene expression. Design Human umbilical vein endothelial cells were cultured in the presence and absence of STBM. At specified time points, total RNA was purified from...... the umbilical cords. Methods Gene expression was screened by Affymetrix GeneChips and confirmed with real-time polymerase chain reaction or enzyme-linked immunosorbent assay. Main outcome measures Fold changes in gene expression levels between treated and control cultures were calculated from the microarray...

  6. Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis

    Science.gov (United States)

    de Freitas, Cláudia V. Marques; Câmara, Sara Filipa Camacho; Vieira, José Joaquim Nunes

    2016-01-01

    Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. It affects 3 to 10 percent of women of reproductive age. Umbilical endometriosis is rare, with an estimated incidence of 0.5–1.0% among all cases of endometriosis, and is usually secondary to prior laparoscopic surgery involving the umbilicus. In this report, we described a case of umbilical endometriosis treated with surgical resection and highlight the great importance of medical history compared to complementary diagnostic tests that can be sometimes inconclusive. PMID:27747115

  7. Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis

    Directory of Open Access Journals (Sweden)

    Marlene Teixeira Andrade

    2016-01-01

    Full Text Available Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. It affects 3 to 10 percent of women of reproductive age. Umbilical endometriosis is rare, with an estimated incidence of 0.5–1.0% among all cases of endometriosis, and is usually secondary to prior laparoscopic surgery involving the umbilicus. In this report, we described a case of umbilical endometriosis treated with surgical resection and highlight the great importance of medical history compared to complementary diagnostic tests that can be sometimes inconclusive.

  8. Umbilical venous catheter retrieval in a 970 gm neonate by a novel technique

    Directory of Open Access Journals (Sweden)

    Arima Nigam

    2014-01-01

    Full Text Available Umbilical venous catheterization is a necessity for the advanced care of very low birth weight neonates. Even with utmost care, few complications cannot be avoided. Fractured and retained catheter fragments are one of them. Endoluminal retrieval of such a catheter is an uncommon and challenging procedure for the interventionist. The only alternative is an open exploration of these patients. Various techniques have been described for retrieval of such foreign bodies. We describe a novel technique for percutaneous retrieval of an embolized umbilical venous catheter from a very low birth weight neonate.

  9. Las capacidades y las potencialidades humanas, ¿son posibles en la época del hombre virtual?

    OpenAIRE

    Becerra, Aída

    2000-01-01

    Se analizan las nociones que aluden a características humanas, desde la psicología humanista, revisando la aportación de autores como Abraham Maslow, Viktor Frankl, Rollo May y Carl Rogers. Se incluye la reproducción en blanco y negro de obra del artista plástico Samuel Meléndrez.

  10. A Vontade de Vida Schopenhaueriana como a Essência Humana: Um Golpe à Presunção Racional

    OpenAIRE

    Camila Koerich Espíndola

    2009-01-01

    O presente artigo tem o objetivo de mostrar que a Vontade de vida, apresentada por Arthur Schopenhauer como a essência íntima tanto dos seres humanos quanto da natureza em geral, pode ter o efeito de igualar a humanidade aos demais seres vivos, abalando a presunção humana fundamentada na capacidade racional.

  11. A Vontade de Vida Schopenhaueriana como a Essência Humana: Um Golpe à Presunção Racional

    Directory of Open Access Journals (Sweden)

    Camila Koerich Espíndola

    2009-06-01

    Full Text Available O presente artigo tem o objetivo de mostrar que a Vontade de vida, apresentada por Arthur Schopenhauer como a essência íntima tanto dos seres humanos quanto da natureza em geral, pode ter o efeito de igualar a humanidade aos demais seres vivos, abalando a presunção humana fundamentada na capacidade racional.

  12. Toxicología de las dioxinas y su impacto en la salud humana

    Directory of Open Access Journals (Sweden)

    Anastasia Cruz Carrillo

    2010-06-01

    Full Text Available Las dioxinas son contaminantes de síntesis que se forman de manera espontánea en diversos procesos industriales. Son compuestos organoclorados muy estables en el medio ambiente, capaces de permanecer en los tejidos humanos y animales; y por ello hacen bioacumulación, lo que facilita la presentación de toxicidad crónica, dentro de la que se destaca la carcinogenicidad, la mutagenicidad y el efecto disruptor endocrino. Se hace referencia a las características físicoquímicas de estos compuestos, a su toxicodinamia y efectos adversos, para finalmente, relacionar la toxicidad de estos compuestos con la salud humana y con la responsabilidad de producir alimentos inocuos para el ser humano.

  13. Contenido orgánico de extractos parcialmente purificados de pulpa dental humana y bovina

    OpenAIRE

    María Mercedes Salas; María Luisa de la Casa; María Elena López

    2011-01-01

    La pulpa dental contiene tejido conectivo rico en proteínas, mayormente colágeno. El objetivo de este trabajo fue describir un método de purificación de componentes orgánicos pulpares humanos y bovinos, vital y necrótico para validar el modelo experimental bovino. Se prepararon extractos con 50 mg de fracción media de pulpas unirradiculares, 20 humanas o 1 bovina, en 500 µL de Tris-HCl 50 mM pH 7,4, floruro de fenil metil sulfonilo 1mM e hidrocloruro de benzamidina 5 mM frío. Se homogeneizó y...

  14. Dientes y diversidad humana: avances de la antropología dental

    OpenAIRE

    Rodríguez Cuenca, José Vicente

    2003-01-01

    La antropología dental estudia la evolución de las enfermedades dentales, la variación morfológica y métrica de la dentición en las poblaciones humanas, su relación con los procesos adaptativos y con los cambios en la alimentación. / Contenido. Preliminares; Capítulo 1 - Los dientes de la historia; Capítulo 2 - Evolución del sistema dental; Capitulo 3 - Variación dental morfológica; Capítulo 4 - Variación en el tamaño de los dientes; Capítulo 5 - Edad y desarrollo dental; Capítulo 6 - Diente...

  15. Emocionalidad y moralidad en el debate sobre la clonación humana

    OpenAIRE

    Santiago Gabriel Calise

    2015-01-01

    El artículo que se presenta a continuación está dedicado al análisis de las emociones desplegadas en el debate bioético en torno del tema de la clonación humana. Al igual que respecto de otras innovaciones científicas que generan polémica, las posiciones suelen tender hacia el miedo o la esperanza. Aquí, a través de los conceptos de P. Livet, se pondrá el acento en el análisis de la relación entre las emociones desplegadas, los valores que estas emociones revelan y el proceso de revisión d...

  16. Comparación de la actividad psíquica humana desde una perspectiva evolutiva

    OpenAIRE

    Rosalía Montealegre

    1996-01-01

    Se parte de la teoría de la evolución de Darwin y se plantea: l. La acción de lo biológico y lo cultural en el desarrollo, analizada desde la psicología historicocultural, la etología humana, la sociobiología. Al centrarse este trabajo en la posición de la psicología historicocultural, se enfatiza lo cultural y el proceso de asimilación del desarrollo histórico de la sociedad por parte del individuo. 2. La actividad psíquica en primates, analizando lo psíquico desde la psicología ...

  17. SOBRE A CONDIÇÃO HUMANA NO PENSAMENTO DE HANNAH ARENDT E KARL MARX

    Directory of Open Access Journals (Sweden)

    Leonardo Pellegrinello Camargo

    2013-12-01

    Full Text Available Neste artigo, abordamos a diferenciação entre trabalho e obra no pensamento de Hannah Arendt, que, embora pareçam para a modernidade conceitos similares ou até idênticos, para a filósofa esta diferenciação é crucial para uma abordagem crítica necessária da condição humana durante e após o século XX. Isto posto, expomos o conceito marxista de trabalho e a posterior crítica feita por Arendt para construir o seu pensamento político acerca da humanidade no pós-guerra.

  18. Antecedentes filosóficos e teológicos do conceito pascaliano de natureza humana

    OpenAIRE

    Luís C. G. Oliva

    2006-01-01

    O artigo pretende examinar os antecedentes do conceito pascaliano de natureza humana, desde a matriz aristotélica da idéia de natureza, passando pela absorção do conceito pelo pensamento cristão de Agostinho e Tomás, pela constituição do conceito teológico de pura natureza na escolástica tardia e sua crítica por Jansenius. Pascal aprofunda essa crítica, mostrando que a completude e a suficiência pressupostas na idéia de pura natureza são incompatíveis com a atual condição do homem, embora a i...

  19. Excelência Humana: a contribuição da personalidade

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    Seille Cristine Garcia-Santos

    2012-08-01

    Full Text Available Este estudo teve por objetivo analisar, sob o enfoque da Psicologia Positiva, as explicações dos pesquisadores da excelência humana sobre o que a promove e a mantém nos mais variados domínios de atuação. Constatou-se que fatores pessoais e contextuais são mencionados, destacando-se as habilidades cognitivas e a prática deliberada no desempenho superior, sendo também as variáveis de personalidade decisivas para o desenvolvimento e a manifestação da excelência. Neste estudo, como na literatura na área, destaca-se a importância da persistência, controle emocional e abertura à experiência.

  20. Las virtudes en una teoría de la acción humana

    OpenAIRE

    Argandoña, Antonio

    2010-01-01

    La economía convencional se basa en una teoría de la acción humana sencilla, que ha mostrado ser eficaz en muchos casos, pero que presenta también inconvenientes importantes. Este capítulo presenta una teoría de la acción más rica, desarrollada con categorías económicas pero inspirada en la filosofía y la teología de base aristotélico-tomista, que permite superar esos inconvenientes, abriendo una vía natural, no forzada, al papel de los hábitos operativos (virtudes) en la acción y, por tanto,...

  1. Ecosystem approaches to human health Abordagens ecossistêmicas à saúde humana

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    N. Ole Nielsen

    2001-01-01

    Full Text Available The promotion of human health must be embedded in the wider pursuit of ecosystem health. Interventions will be impaired if ecosystem-linked determinants of health are not taken into account. In the extreme case, if ecosystems lose their capacity for renewal, society will lose life support services. Essential features of ecosystem health are the capacity to maintain integrity and to achieve reasonable and sustainable human goals. An ecosystem approach to research and management must be transdisciplinary and assure participation of stakeholders. These requisites provide a means for science to better deal with the complexity of ecosystems, and for policy-makers and managers to establish and achieve reasonable societal goals. The ecosystem approach can determine links between human health and activities or events which disturb ecosystem state and function. Examples are: landscape disturbance in agriculture, mining, forestry, urbanization, and natural disasters. An understanding of these links can provide guidance for management interventions and policy options that promote human health. An ecosystem approach to management must be adaptive because of irreducible uncertainty in ecosystem function.A promoção da saúde humana deve estar embutida na busca maior pela saúde do ecossistema. As intervenções estarão prejudicadas se os determinantes ecossistêmicos da saúde não forem levados em conta. Em caso extremo, se os ecossistemas perderem a capacidade de se renovarem, a sociedade ficará privada de serviços essenciais à sustentação da vida. As características essenciais da saúde ecossistêmica são a capacidade de manter a integridade e a de atingir metas humanas razoáveis e sustentáveis. Uma abordagem ecossistêmica para a pesquisa e gestão deve ser transdisciplinar e assegurar a participação dos diferentes atores. Tais características fornecem um meio à ciência para lidar melhor com a complexidade dos ecossistemas, bem como aos

  2. La espiritualidad y la solución de crisis humanas

    Directory of Open Access Journals (Sweden)

    Rosalvina Alvis Barranco

    2015-01-01

    Full Text Available El presente artículo es un ensayo que compara tres estrategias de si- coterapia para el tratamiento de los conflictos humanos, demostrándose que la evocación de la espiritualidad humana ofrece resultados compara- bles cuando se aplica la psicoterapia cognitiva y la logoterapia. Se reali- zó un ensayo clínic o y a doble ciegas entre los 1.500 pacientes atendidos en la oficina de Asesoría Espiritual de la Universidad Popular del Cesar entre los años 2011-2014. Una conceptualización del caso sólida y bien estructurada, incrementa las probabilidades de éxito terapéutico.

  3. Misión y vocación universitaria y persona humana

    Directory of Open Access Journals (Sweden)

    Jesús GONZÁLEZ LÓPEZ

    2009-11-01

    Full Text Available RESUMEN: El artículo es una reflexión del autor sobre el sentido y fines que la Universidad debe buscar en Chile en la perspectiva de un nuevo siglo. La Universidad debe constituirse, en primer lugar, como comunidad humana e intelectual. Pero, en segundo lugar, la dimensión ética de la persona es una perspectiva de fondo que no puede abandonar ninguna tarea desarrollada en la Universidad.ABSTRACT: This article is a reflection about the meaning and goals of the University in Chile at the thresold of the next century. First of all, the University must be a human and intellectual community. But the ethical dimension of the person is also most important for the universitary task.

  4. Diagnóstico de la toxocarosis humana Diagnosis of human toxocarosis

    Directory of Open Access Journals (Sweden)

    William H. Roldán

    2010-12-01

    Full Text Available La toxocarosis humana es una importante zoonosis parasitaria causada por formas larvarias de especies del género Toxocara, un parásito nematodo de los perros y los gatos. La migración de la larva por los diferentes tejidos blandos en el ser humano genera una serie de entidades clínicas en el paciente, tales como el síndrome de larva migrans visceral, la toxocarosis ocular y la neurotoxocarosis. El diagnóstico definitivo es mediante la histopatología en biopsias, pero resulta ser casi imposible de realizar y actualmente su diagnóstico se establece mediante el análisis de la sintomatología clínica, los antecedentes epidemiológicos del paciente y el uso de pruebas hematológicas e inmunológicas de laboratorio que son las que finalmente ayudan a confirmar la sospecha clínica de la enfermedad. El propósito del presente artículo es actualizar los conocimientos que se tienen sobre el uso de las diferentes herramientas para establecer el diagnóstico y el monitoreo de la toxocarosis humana.Human toxocarosis is an important parasitic zoonosis caused by larval stages of Toxocara species, the roundworms from dogs and cats. Larval migration through different soft tissues in the human generates several clinical entities in the patient, such as visceral larva migrans, ocular toxocarosis, and neurotoxocarosis. Definitive diagnosis by histopathological methods is very difficult or almost impossible and, nowadays, the diagnosis is usually made by clinical signs/symptoms, epidemiological background of the patient and the use of hematological and immunological tests which finally help to confirm the clinical suspicion of the illness. The purpose of this paper was to update the available knowledge on the use of different tools for both the diagnosis and following up of human toxocarosis.

  5. NEUROÉTICA Y VULNERABILIDAD HUMANA EN PERSPECTIVA FILOSÓFICA

    Directory of Open Access Journals (Sweden)

    ALFREDO MARCOS

    2015-01-01

    Full Text Available El artículo trata de valorar las posibilidades y límites de la neuroética. Defiende que las neurociencias y la ética deben colaborar entre sí desde el mutuo respeto y la preservación de las respectivas identidades, científica en un caso y filosófica en el otro (neuroética en modo-co . El texto formula también una crítica a todo intento de sustitución de la ética filosófica por las neurociencias (neuroética en modo-su. En consecuencia, se exploran los fundamentos ontológicos y antropológicos más apropiados para desarrollar la neuroética, entendida esta como territorio de colaboración entre ética y neurociencias. Dichos fundamentos remiten a la idea aristotélica de sustancia hilemórfica. Sobre tales fundamentos se puede desarrollar una neuroética colaborativa que incluye dos vertientes: por un lado tenemos una ética de la neurociencia y, por otro, una neurociencia de la ética. La primera muestra cómo investigar y aplicar la neurociencia preservando siempre la dignidad humana. La segunda nos enseña cuáles son las bases neurobiológicas posibilitadoras –pero no determinantes– de la agencia moral. Al estudiar las mismas se hace evidente nuestra vulnerabilidad como agentes morales. Esta vulnerabilidad, que arraiga en la propia naturaleza humana, ha de ser, como se argumenta en el último tramo del texto, reconocida y a la vez mitigada.

  6. Enfermedades infecciosas emergentes: interacción entre el mundo microbiano y las sociedades humanas

    Directory of Open Access Journals (Sweden)

    Fernando García

    2008-09-01

    Full Text Available En este artículo se analizan dos facetas importantes de las enfermedades infecciosas emergentes. Por un lado, las características de los microorganismos que las causan, por otro, las características del ser humano que promueven o contribuyen al surgimiento de las enfermedades infecciosas. Desde el punto de vista microbiano, se pueden identificar tres aspectos fundamentales. Primero, los patógenos emergentes son predominantemente virales, seguidos por los bacterianos. Numéricamente los virus ARN dominan, constituyendo el 37% de todos los patógenos emergentes. Los virus ARN predominan entre los virus patógenos emergentes que aparentemente entraron en las poblaciones humanas en las últimas décadas, como VIH y el coronavirus asociado al SARS. Segundo, los patógenos emergentes no se asocian a un único tipo de hospedero, sino que usualmente tienen amplio rango de hospederos que incluye varios órdenes de especies de mamíferos y no mamíferos. En efecto, la mayoría de las infecciones emergentes son de origen zoonótico. Tercero, los patógenos emergentes tienen un cierto grado de flexibilidad biológica que les permite aprovecharse de nuevas oportunidades epidemiológicas para ingresar a las poblaciones humanas. Las enfermedades infecciosas no son un problema reciente sino que han estado "emergiendo" a lo largo de la historia de la humanidad y es posible identificar, al menos, cuatro transiciones históricas. La última de esas transiciones es la globalización actual. Muchos factores antropogénicos inciden en el surgimiento de las enfermedades infecciosas emergentes, incluyendo eventos sociales, comportamiento humano, cambios ambientales, políticas en salud pública, procedimientos médicos y otros.

  7. La Placenta Humana Nuevo Sustrato Proteico Empleado para la Obtención de Bases Nutritivas.

    Directory of Open Access Journals (Sweden)

    Diana Rosa Viera Oramas

    2005-01-01

    Full Text Available El hidrolizado de placenta humana es una nueva base nutritiva con un elevado contenido de nutrientes y constituyen un paso importante en el desarrollo de una metodología para su obtención a partir de residuos de placenta. Además de ser un nuevo producto en la gama de BIOCEN y brindar la posibilidad de utilizar en sustitución de bases nutritivas importadas. Con el objetivo de desarrollar y evaluar la funcionalidad de dicha base se realizó un diseño experimental completamente aleatorio, se estudió la influencia de parámetros fundamentales en el proceso de obtención tales como: cantidad de enzima, tiempo de hidrólisis y relación sustrato agua. Definiendo que 0,4 g de papaína por Kg de sustrato, durante 4 hora de hidrólisis y en una relación 1: 5 sustrato agua, además de un tratamiento térmico durante 30 min fueron los elementos críticos prefijados en la tecnología de obtención del hidrolizado. Se obtuvo un producto con elevada calidad cuyos valores óptimos de los índices fisicoquímicos fueron: nitrógeno amínico 2,38 % nitrógeno total 13,62 % y un rendimiento 14,56 % . Al realizar la evaluación microbiológica de la peptona a nivel piloto se obtuvieron resultados satisfactorios y correspondiente a los descrito en la documentación. Esta nueva base nutritiva es una prueba de la posibilidad de utilizar los residuos de placenta humana en calidad de sustrato proteico con una calidad adecuada comparable con los productos de similar propósito existentes en el mercado internacional.

  8. Direito e reprodução humana assistida nas uniões homoafetivas

    Directory of Open Access Journals (Sweden)

    José Márcio Carvalho da Silva

    2014-10-01

    Full Text Available A reprodução humana assistida em uniões homoafetivas é uma temática envolta em controvérsias na sociedade contemporânea, motico pelo qual o Poder Judiciário frequentemente é acionado no intuito de dirimir os conflitos existentes. Apesar da união de pessoas do mesmo sexo ser uma configuração familiar cada vez mais frequente no Brasil, o ordenamento brasileiro ainda é frágil em relação ao deslinde da questão. A inexistência de mecanismos legais específicos no país coloca o assunto em uma posição vulnerável a questionamentos éticos, morais, médicos, religiosos e sociais. Considerando este cenário de inegável transformação da estrutura familiar, o presente trabalho teve como objetivo principal analisar as repercussões jurídicas da reprodução humana assistida nas uniões homoafetivas. As considerações trazidas por este trabalho sinalizam que mesmo diante de alguns avanços, lacunas importantes necessitam ser preenchidas no âmbito do Direito. Algumas sentenças já foram favoráveis ao reconhecimento da paternidade e maternidade de casais homoafetivos cujos filhos foram gerados por meio de métodos de reprodução assistida, entretanto, as respostas aos dilemas que envolvem esse tipo de cinstituição familiar contemporânea ainda carecem de mecanismos legais mais concretos.

  9. La díada en el desarrollo de la condición humana

    Directory of Open Access Journals (Sweden)

    Carmen Rosalía Solla

    2011-05-01

    Full Text Available Este artículo tiene como propósito realizar una disertación sobre la díada como estrategia socializadora que coadyuva al desarrollo de la condición humana, entendiendo ésta como la fuerza viva de interrelacionarse con su semejante, respetarlo, amarlo y ser empático son ese otro que está ahí para ser el complemento de uno. Esta investigación se desarrolla como un estudio documental, de tipo expositivo, ya que en éste se presentan los estudios de Valles (2004, Hernández y Cortés (2009, Solla (2003/2010 y, Rodríguez (2009 y se hace referencia a las teorías de Gadamer (1997, Heidegger (2003 y Bronfenbrenner (1987 como soportes al estudio de las relaciones complementarias, específicamente de la díada. Los trabajos antes mencionados se exponen en forma dialógica para que así uno sea complemento del otro. El artículo está compuesto por varias partes que guían al lector a entender al individuo desde su unicidad hasta la necesidad de complementarse con el otro quien le ayuda a ratificar su condición humana. Finalmente, se concluye que el ser humano, desde la relación diádica, abre su ser para desplegarse en el otro; promueve la interrelación, la comunicación, la cohesión, la afectividad, la reciprocidad, la solidaridad, el respeto y la dialógica; trabaja con su semejante y posibilita la formación de comunidades cohesionadas.

  10. Habermas, identidad moderna y mejora humana. ¿El camino a seguir?

    Directory of Open Access Journals (Sweden)

    Francisco Javier Lopez Frías

    2014-10-01

    Full Text Available La finalidad de este artículo es triple. Primero, las secciones 1 y 2 expondrán la estructura del argumento de Jürgen Habermas respecto a las tecnologías de mejora humana. Para ello, éste será descompuesto en tres partes, que son sus pilares básicos: a los sujetos diseñados no pueden auto-concebirse a sí mismos como autores únicos de sus vidas; b la distinción kantiana entre objetos y personas se desvanece como consecuencia del modo en que los sujetos modificados experiencian su cuerpo; c la relación entre los padres y su descendencia se vuelve asimétrica, de modo que es contraria a las normas de la acción comunicativa. Segundo, en la sección 3, que es concebida como un diálogo entre Habermas y sus críticos, se presentarán algunas objeciones teóricas a su argumento. Tercero, la sección 4 analizará la validez de los argumentos habermasianos y afirmará firmemente que la posición de Habermas arroja luz sobre el modo correcto de analizar las tecnologías de mejora humana desde un punto de vista moral. A saber, en función de la influencia que tienen sobre el modo en que los sujetos se auto-conciben como seres autónomos y responsables.

  11. Xeno-free culture condition for human bone marrow and umbilical cord matrix-derived mesenchymal stem/stromal cells using human umbilical cord blood serum

    Science.gov (United States)

    Esmaeli, Azadeh; Moshrefi, Mojgan; Shamsara, Ali; Eftekhar-vaghefi, Seyed Hasan; Nematollahi-mahani, Seyed Noureddin

    2016-01-01

    Background: Fetal bovine serum (FBS) is widely used in cell culture laboratories, risk of zoonotic infections and allergic side effects create obstacles for its use in clinical trials. Therefore, an alternative supplement with proper inherent growth-promoting activities is demanded. Objective: To find FBS substitute, we tested human umbilical cord blood serum (hUCS) for proliferation of human umbilical cord matrix derived mesenchymal stem cells (hUC-MSCs) and human bone marrow-derived mesenchymal cells (hBM-MSCs). Materials and Methods: Umbilical cord blood of healthy neonates, delivered by Caesarian section, was collected and the serum was separated. hUC-MSCs and hBM-MSCs were isolated and characterized by assessment of cell surface antigens by flow cytometry, alkaline phosphatase activity and osteogenic/adipogenic differentiation potential. The cells were then cultured in Iscove's Modified Dulbecco's Medium (IMDM) by conventional methods in three preparations: 1- with hUCS, 2- with FBS, and 3- without serum supplements. Cell proliferation was measured using WST-1 assay, and cell viability was assessed by trypan blue staining. Results: The cells cultured in hUCS and FBS exhibited similar morphology and mesenchymal stem cells properties. WST-1 proliferation assay data showed no significant difference between the proliferation rate of either cells following hUCS and FBS supplementation. Trypan blue exclusion dye test also revealed no significant difference for viability between hUCS and FBS groups. A significant difference was detected between the proliferation rate of stem cells cultured in serum-supplemented medium compared with serum-free medium. Conclusion: Our results indicate that human umbilical cord serum can effectively support proliferation of hBM-MSCS and hUC-MSCs in vitro and can be used as an appropriate substitute for FBS, especially in clinical studies. PMID:27738658

  12. 介入化疗栓塞术联合体外高频热疗治疗晚期肝癌临床观察%The clinical observation of transcatheter arteria chemoembolization combined with external high frequency thermotherapy for advanced hepatic cancer

    Institute of Scientific and Technical Information of China (English)

    郑剑霄; 吴万垠; 邓宏; 龙顺钦

    2009-01-01

    Objective To evaluate the efficacy and side effects of transeatheter arteria chemoembolization combined with external high frequency thermotherapy for advanced hepatic cancer.Methods Thirty nine patients were randomly divided into 2 groups ,one group with 19 cases,the other 20 cases.The observed group was treated by transcatheter arteria.chemoembolization combined with external high frequency thermotherapy,and the control group by ordinary transcatheter arteria chemoembolization.Result The response rate with the observed group and control group were 73.7%(14/19) and 40%(8/20)respeetively(P<0.05),and its side effects was not increased.There was no significant difference in the survival rate.Conclusions The short term efficacy of the advanced hepatic cancer is improved by transcatheter arteria chemoembolization combined with external high frequency thermotherapy and its side effects is not increased.%目的 比较介入化疗栓塞术联合体外高频热疗与单纯介入化疗栓塞术治疗晚期肝癌的疗效和毒副反应.方法 39例晚期原发性肝癌患者随机分为两组,观察组19例,对照组20例.观察组行介入化疗栓塞术联合体外高频热疗,对照组行单纯介入化疗栓塞术治疗.结果 观察组总有效率73.7%(14/19);对照组总有效率40%(8/20),观察组的治疗有效率较对照组明显提高(P<0.05),毒副反应未增加.0.5年、1年生存率两组差异无显著性(P>0.05).结论 介入化疗栓塞术联合体外高频热疗提高了晚期肝癌的近期疗效,且不增加毒副作用.

  13. Early vs delayed clamping of the umbilical cord in full term, preterm and very preterm infants

    DEFF Research Database (Denmark)

    Moller, N.K.; Weber, T.

    2008-01-01

    Randomized studies from 2006 and two meta-analyses published in 2007 agree that clamping of the umbilical cord can be delayed. For the preterm and very preterm infant benefits include less need for blood transfusion and less morbidity, especially for the very preterm male infant. For the term...

  14. Optical data transmission technology for fixed and drag-on STS payload umbilicals, volume 2

    Science.gov (United States)

    St.denis, R. W.

    1981-01-01

    Optical data handling methods are studied as applicable to payload communications checkout and monitoring. Both payload umbilicals and interconnecting communication lines carrying payload data are examined for the following: (1) ground checkout requirements; (2) optical approach (technical survey of optical approaches, selection of optimum approach); (3) survey and select components; (4) compare with conventional approach; and (5) definition of follow on activity.

  15. Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo*

    Institute of Scientific and Technical Information of China (English)

    Cungang Fan; Dongliang Wang; Qingjun Zhang; Jingru Zhou

    2013-01-01

    High-grade glioma is the most common malignant primary brain tumor in adults. The poor prognosis of glioma, combined with a resistance to currently available treatments, necessitates the ment of more effective tumor-selective therapies. Stem cel-based therapies are emerging as novel cel-based delivery vehicle for therapeutic agents. In the present study, we successful y isolated human umbilical cord mesenchymal stem cel s by explant culture. The human umbilical cord senchymal stem cel s were adherent to plastic surfaces, expressed specific surface phenotypes of mesenchymal stem cel s as demonstrated by flow cytometry, and possessed multi-differentiation potentials in permissive induction media in vitro. Furthermore, human umbilical cord mesenchymal stem cel s demonstrated excel ent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. The excellent glioma-specific targeting ability and extensive intratumoral distribution of human umbilical cord mesenchymal stem cel s indicate that they may serve as a novel cel ular vehicle for delivering the-rapeutic molecules in glioma therapy.

  16. A Review of Factors Influencing the Banking of Collected Umbilical Cord Blood Units

    Directory of Open Access Journals (Sweden)

    David Allan

    2013-01-01

    Full Text Available Umbilical cord blood banking efforts have increased dramatically in the past two decades in response to increasing demand for alternative sources of blood stem cells to support patients requiring hematopoietic stem cell transplantation. Transplant centres have accumulated increasing expertise in their understanding of umbilical cord blood characteristics that are associated with improved outcome following transplantation. These characteristics and factors can assist transplant centres in selecting cord blood units from the worldwide inventory of banked units. Umbilical cord blood banks, therefore, need to remain agile in adjusting the inventory of the banks to address shifts or changes in the needs of transplant centres. Public umbilical cord blood banks face the challenge of building inventory while managing limited resources and are faced with decisions regarding which units can be stored and which units that have been collected should be discarded or used for other endeavours such as research. To this end, we sought to review parameters influencing the decision to bank a collected cord blood unit. In this paper, we will address parameters associated with graft potency and address other factors that guide the decision to bank collected units.

  17. Umbilical hernia rupture with evisceration of omentum from massive ascites: a case report.

    LENUS (Irish Health Repository)

    Good, Daniel W

    2011-01-01

    The incidence of hernias is increased in patients with alcoholic liver disease with ascites. To the best of our knowledge, this is the first report of an acute rise in intra-abdominal pressure from straining for stool as the cause of a ruptured umbilical hernia.

  18. Unstimulated platelets evoke calcium responses in human umbilical vein endothelial cells

    NARCIS (Netherlands)

    van IJzendoorn, S C; van Gool, R G; Reutelingsperger, C P; Heemskerk, J W

    1996-01-01

    Interactions between human platelets and human umbilical vein endothelial cells (HUVEC) were studied by monitoring changes in cytosolic [Ca2+]i in both cell types. Confluent monolayers of Fura-2-loaded HUVEC, grown on gelatin-coated coverslips, responded to repeated addition of a suspension of unsti

  19. Umbillical venous volume inflow and liver size in normal and abnormal fetal development

    NARCIS (Netherlands)

    S.M. Boito

    2003-01-01

    textabstractIn this thesis the following research objectives were addressed: To calculate umbilical venous volume flow from cross-sectional area and flow velocity measurements with emphasis on: (i) the reproducibility of component measurements; (ii) normal and abnormal fetal development, the latter

  20. Investigation of the cytotoxicity of CCVD carbon nanotubes towards human umbilical vein endothelial cells

    OpenAIRE

    Flahaut, Emmanuel; Durrieu, Marie-Christine; Remy-Zolghadri, Murielle; Bareille, Reine; Baquey, Charles

    2006-01-01

    The cytotoxicity of different samples of carbon nanotubes synthesised by catalytic chemical vapour deposition was investigated towards human umbilical vein endothelial cells, using two cytotoxicity standard assays (neutral red assay for the cell viability and MTT assay—tetrazolinium salt—for the cell metabolic activity). No cytotoxicity was found for any sample.

  1. Four Step Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells Within Hydrogel Scaffold Into Hepatocytes

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    Saeed Azandeh

    2015-09-01

    Full Text Available Introduction: Due to increasing demand for liver tissue engineering, three-dimensional (3D liver cells culture techniques have been proposed. Therefore, the aim of the present study was to examine the cells isolation and expansion of umbilical cord derived mesenchymal stem cells and in vitro 2D and 3D hepatocyte differentiation.Alsofunctional characteristics of hepatocytes were analyzedMethods: The study performed in several phases. In the first umbilical cord derived mesenchymal stem cells obtained and isolated, thereafter cellss expanded. Determination of Immunophenotype using Flow. Cytometry performed by DAKO – Galaxy Hepatic differentiation UC-MSCs was performed by four step sequential method using FGF-4, ITS, HGF, dexamethasone, glucagon, OSM and TSA. Urea production was quantified by ELISA.Section of tissue constructs stained with hematoxyllin and eosin for histological examinationResults: MSCs isolated from umbilical cord expressed mesenchymal surface antigen such as CD73, but were negative against CD31. Several cell clusters mainly between the round cells were observed in alginate scaffold after 3d differentiation. Urea production was increased time- dependable and was significantly higher in the experimental group of 3D culture (P=0.001. Tissue construct of 3D culture revealed multicellular tissue with several euchromatin cell plates.Conclusion: The finding of the present study indicated that four step differentiation of umbilical cord derived mesenchymal stem cells within hydrogel scaffold induced functionally and morphologically characteristics of hepatocytes such as urea production and cell plates.

  2. Abnormal umbilical artery Doppler in third trimester and perinatal outcome: a retrospective study

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    Shiny Varghese

    2016-07-01

    Conclusions: Umbilical artery Doppler helps in the prediction of possible maternal and foetal complications in cases of compromised placental flow. Monitoring of antenatal parameters, availability of emergency facility for early surgical intervention and neonatal care pave a long way in curtailing perinatal morbidity and mortality. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2196-2199

  3. Isolation, culture and characterization of postnatal human umbilical vein-derived mesenchymal stem cells

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    "Mehdi Kadivar

    2005-07-01

    Full Text Available On the basis of reports that mesenchymal stem cells (MSCs can be isolated from the placenta/umbilical cord stroma, the present study was undertaken to isolate and characterize MSCs from the human umbilical cord veins. In this investigation, a cell population was isolated which was derived from the endothelium/subendothelium layers of 20 umbilical cord veins obtained from term deliveries using a solution of 0.1% collagenase type IV. Results suggest that these cells possess morphological, immunophenotypical and cell differentiation capacities similar to the bone marrow-derived mesenchymal stem cells (MSCs. The isolated cell population has fibroblastoid morphology which upon proper stimulation gives rise to adipocytes, osteocytes and chondrocytes in culture. Immunophenotypically, this cell population is positive for CD54, CD29, CD73, CD49e, CD166, CD105, CD13, and CD44 markers and alpha-smooth muscle actin and negative for CD31, CD45, CD49d, and CD34 markers, von Willebrand factor (vWF and smooth muscle myosin (MySM. Altogether, these findings indicate that umbilical cord obtained from term deliveries is an important source of MSCs which could have an important application in cell therapy protocols.

  4. Comparison of Maternal and Umbilical Cord Blood Selenium Levels in Low and Normal Birth Weight Neonates

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    Lyly Nazemi

    2015-10-01

    Full Text Available Objective:To compare the maternal and umbilical cord serum selenium concentrations in Low and normal birth weight neonates.Materials and methods:A case-control study was carried out in Vali-Asr and Akbarabadi Hospitals (Jan. to Dec. 2013. Two groups; case group; 91 mothers who delivered a low birth weight (LBW neonate and control group; 86 subjects who delivered a normal birth weight neonate were selected. Immediately after birth, 5 ml of maternal blood and umbilical cord blood were collected, and sent to laboratory to assay Se concentrations. To compare both groups' blood Se concentration, data were analyzed in SPSS 16.0.Results:Eighty six (48.6% mothers with normal birth weight neonates and 91 (51.4% mothers with low birth weight infants entered the study. Mean maternal mothers' age and mean maternal blood Se were 28.55+5.90 years and 79.3756+26.46915. A significant association was seen between maternal blood and cord blood Se level in control and case group (P value<0.0001, r = 0.69 and(P value<0.001, r = 0.79. On the other hand no differences were seen between 2 groups' maternal blood Se level (P Value = 0.65. Umbilical Cord blood Se concentration was not also different between case and control group (P value = 0.46.Conclusion:We found that maternal and umbilical cord blood Se concentrations were not different in low and adequate birth weight infants, however; umbilical cord Se concentrations were positively correlated with maternal blood Se concentrations.

  5. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

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    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value

  6. Angiotomografia coronariana multislice na avaliação da origem anômala das artérias coronarianas Angiotomografía coronaria multislice en la evaluación del origen anómalo de las arterias coronarias Multislice coronary angiotomography in the assessment of coronary artery anomalous origin

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    Daniel Rocha Rabelo

    2012-03-01

    Full Text Available Fundamento: A origem anômala das artérias coronarianas é uma entidade relativamente rara, podendo se apresentar de várias formas clínicas e evoluir de forma adversa. A angiotomografia multislice das artérias coronarianas vem ganhando espaço na prática clínica diária, representando importante método propedêutico, com grande potencial na avaliação anatômica dessas artérias. Objetivo: O objetivo deste estudo é descrever os achados angiotomográficos e a evolução de pacientes com origem anômala das artérias coronarianas. Métodos: Durante o período de janeiro de 2008 a março de 2011, foram avaliados consecutivamente 404 pacientes encaminhados para realização de angiotomografia das coronárias por diversos motivos, com tempo médio de seguimento de 21 meses. Resultados: Nove pacientes (2,2% apresentaram origem anômala das artérias coronárias, sendo quatro com origem anômala da artéria circunflexa (Cx em Coronária Direita (CD, dois com origem anômala da CD (um com origem de CD em Cx, e um com origem de CD em seio coronariano esquerdo, um paciente com tronco coronariano único (descendente anterior e Cx saindo do seio coronariano esquerdo, um com trajeto anômalo do tronco da coronária esquerda entre aorta e artéria pulmonar e um paciente apresentando tronco coronariano esquerdo originando-se do seio coronariano direito. Dos pacientes avaliados, um paciente recebeu um cardiodesfibrilador implantável; um paciente evoluiu com morte súbita durante internação hospitalar; e os outros não tiveram intercorrências. Conclusão: A angiotomografia multislice das coronárias representa método propedêutico minimamente invasivo que possibilita detectar a origem, o curso e terminação das anomalias de origem das artérias coronarianas com excelente acurácia, possibilitando o correto diagnóstico e auxiliando no planejamento terapêutico.RESUMEN FUNDAMENTO: El origen anómalo de las arterias coronarias es una entidad

  7. Grande fístula bilateral da artéria coronária: a escolha do tratamento clínico Gran fístula bilateral de la arteria coronaria: la selección del tratamiento clínico Large bilateral coronary artery fistula: the choice of clinical treatment

    Directory of Open Access Journals (Sweden)

    Luciana Oliveira Cascaes Dourado

    2009-09-01

    Full Text Available Relatamos o caso de um paciente do sexo feminino, assintomática, com grande fístula bilateral da artéria coronária-artéria pulmonar. O monitoramento clínico foi a opção escolhida para tratamento. Discutimos os pormenores das opções terapêuticas, enfatizando a tendência excessiva de utilizar a abordagem cirúrgica e a grande escassez de acompanhamentos clínicos de longo prazo em pacientes assintomáticos.Relatamos el caso de un paciente del sexo femenino, asintomática, con gran fístula bilateral de la arteria coronaria-arteria pulmonar. El monitoreo clínico fue la opción elegida para el tratamiento. Discutimos los pormenores de las opciones terapéuticas, enfatizando la tendencia excesiva de utilizar el abordaje quirúrgico y la gran escasez de seguimientos clínicos de largo plazo en pacientes asintomáticos.

  8. El concepto de "tradición" en la filosofía de las ciencias sociales y humanas

    OpenAIRE

    Renato Huarte Cuéllar

    2012-01-01

    Para hablar de las ciencias sociales y humanas y lo que las caracteriza en sudiscusión epistemológica, conviene hacer un análisis de lo que autores comoKuhn, Laudan, Popper y Gadamer tienen que aportar a la noción de “tradición”para la filosofía de la ciencia en general y para la filosofía de las cienciassociales y humanas. Además de revisar estos enfoques, considero importanterevisar la definición de lo que es la tradición y una interrelación de elementosentre filosofía y ciencias sociales. ...

  9. Legitimidad de la Huelga de Hambre. Un debate sobre el derecho a la vida y la dignidad Humana

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    Jorge Precht Pizarro

    2013-01-01

    Full Text Available La huelga de hambre es una forma de protesta social, pacífica y extrema al mismo tiempo, en la que se tensionan valores esenciales del individuo, como la vida y la libertad, contenidos ambos en el núcleo mismo de la dignidad Humana. Sobre esta base, estudiamos los alcances de la huelga de hambre, desde sus fundamentos éticos esenciales hasta su dimensión jurídica y constitucional. Entre otros, se revisan los debates en materia de derechos fundamentales, algunas propuestas de tratamiento penal y las colisiones con los derechos de la infancia y adolescencia. En particular, se aborda el tratamiento jurisprudencial que le han dado los Tribunales Superiores de Justicia en Chile, formulando un juicio crítico, fundado en una ética de la Dignidad Humana y en las garantías fundamentales propiamente tales, frente a discutibles argumentaciones jurisprudenciales que han privilegiado soluciones contingentes.

  10. Réplicas y perfección humana: Los niños del Brasil y GATTACA

    OpenAIRE

    Rodríguez, Gemma; Baños Díez, Josep Eladi

    2014-01-01

    [ES] La posibilidad de la clonación humana se ha convertido en una preocupación social tras la aparición de la oveja Dolly en 1997. Los avances de la genética molecular y de las técnicas de reproducción en los últimos treinta años han planteado una situación que parecía muy lejana tras la clonación de ranas en 1952. La visión cinematográfica de la clonación humana ha oscilado desde el terror de La invasión de los ladrones de cuerpos (1956) a la comicidad de El dormilón (1973). En ...

  11. La vida humana como principio interpretativo radical en la filosofía de Ortega y Gasset

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    Antonio Gutiérrez-Pozo

    2012-12-01

    Full Text Available En este artículo presentamos el concepto de vida humana como texto eterno en el pensamiento de Ortega y sus consecuencias para el problema de la interpretación. La filosofía de la razón vital de Ortega se fundamenta en el concepto de vida humana como realidad radical y principio interpretativo universal, y por esta razón se presenta desde el principio como una filosofía hermenéutica de la vida y no como una reducción hacia la conciencia trascendental. Esta hermenéutica se practica especialmente en el ámbito del arte. Pero para Ortega todo texto es hermenéutico y necesita por tanto la interpretación, porque ningún texto posee en sí mismo su verdad.

  12. EFEITO DO CONSUMO DA RAÇÃO HUMANA SOBRE O PERFIL LIPÍDICO E GLICEMIA DE RATOS

    OpenAIRE

    Janine Louise Borré; Vilma Blondet de Azeredo; Paola Núbile Galvão; Solange Augusta de Sá; Antonio Orestes de Salvo Castro

    2014-01-01

    A Ração Humana é considerada um complemento alimentar e uma das novas tendências de dietas da moda. Este estudo avaliou os efeitos da "Ração Humana" sobre o perfil lipídico e glicemia de ratos. Foram utilizados 32 Rattus Wistar, com 45 dias de vida. Os resultados são apresentados como média aritmética e desvio padrão. Para comparação de médias foi utilizado ANOVA one-way, com Tukey como pós-teste. Foi aceito nível de significância de 5%. A glicemia manteve-se semelhante entre os grupos estuda...

  13. Tolerância da placenta à parada circulatória umbilical normotérmica Tolerance of placenta to normothermic umbilical circulatory arrest

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    Renato S Assad

    1992-09-01

    Full Text Available O aumento da resistência vascular placentáriae distúrbios de trocas gasosas freqüentemente ocorrem após a circulação extracorpórea (CEC fetal. A utilização de um circuito convencional de CEC que exclua a placenta da circulação através do clampeamento temporário do cordão umbilical pode proteger a vasculatura placentária dos estímulos que levam ao aumento da resistência vascular. Para avaliar a tolerância placentária à parada normotérmica do fluxo sangüíneo umbílico-placentário, 9 placentas de ovelhas isoladas in-situ, foram colocadas em CEC através da canulação dos vasos umbilicais, com fluxo médio de artéria umbilical de 214 ml/min/kg. Após 30 minutos de estabelecimento da CEC, a circulação placentária foi interrompida por 30 minutos, simulando o clapeamento do cordão umbilical durante a CEC fetal total. Posteriormente, a circulação placentária foi restabelecida aos valores basais. A troca de gases placentária, o fluxo sangüíneo e a resistência vascular materno-placentários foram avaliados antes e depois da parada circulatória. Não houve diferença estatisticamente significante entre os gradientes transplacentários de pO2 e pCO2, indicando que a interrupção do fluxo sangüíneo placentário por 30 minutos, em condições normotérmicas, não afeta a função placentária. Este modelo sugere um método alternativo para a aplicação clínica da CEC fetal, através da exclusão da circulação umbílico-placentária durante a CEC fetal, eliminandose, assim, os efeitos deletérios da CEC nas trocas gasosas placentárias.Elevation of placental vascular resistance (PVR and depression of fetal gas exchange occurs after fetal cardiopulmonary bypass (CPB. Excluding the placenta from the CPB circuit may protect the placental vasculature from the unwanted stimuli which lead to elevated PVR. To evaluate this approach, 9 isolated in-situ sheep placentas were placed on CPB by cannulating the umbilical vessels

  14. Estudio descriptivo de la presentación de brucelosis humana en Colombia desde 2000 hasta 2012

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    Patricia Lopez Guarnizo

    2014-07-01

    Full Text Available El objetivo de la investigación fue realizar un estudio descriptivo de la ocurrencia de brucelosis humana en Colombia entre 2000 y 2012, y con base en estudios previos conocer la prevalencia e incidencia de la enfermedad, las limitaciones para el diagnóstico oportuno y el reconocimiento de la enfermedad por el sistema laboral colombiano. La investigación se basó en la búsqueda y análisis de la información publicada en artículos relacionados con brucelosis humana entre 2000 y 2012 en Colombia. En esta investigación se incluyó una fase de recopilación de información y entrevistas no estructuradas a representantes de programas de control de brucelosis y a profesionales expertos. Se analizaron 17 trabajos de brucelosis humana realizados en el personal a riesgo en plantas de beneficio, expendedores y vacunadores del programa de brucelosis animal, en los cuales se reportaron 10 estudios con prevalencias entre 0,14 % y 10,4 % y 7 con seropositividad. En estos se encontró alguna información pertinente a las limitaciones del diagnóstico y se evidenció el poco conocimiento de la comunidad médica frente a la enfermedad. En Colombia no hay una política clara respecto a esta zoonosis de riesgo ocupacional. Solo se menciona la brucelosis en el Decreto 2566 de 2009, en la cual se adopta la nueva tabla de enfermedades profesionales. Se concluye que la brucelosis humana en Colombia es una enfermedad subdiagnosticada y, por lo tanto, subnotificada, ya que no existe un sistema de notificación obligatoria.

  15. Dignidade da pessoa humana e o décimo segundo camelo - sobre os limites da fundamentação de direitos

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    Sobottka, Emil Albert

    2008-01-01

    Full Text Available Dignidade da pessoa humana adquiriu em anos recentes um destaque como princípio fundamental a partir do qual são derivados direitos, considerados igualmente fundamentais. Com base na discussão provocada por Luhmann sobre recursos externos ao direito num sistema definido como operativamente fechado e cognitivamente aberto, o texto discute se a dignidade da pessoa humana consegue ocupar este lugar funcional

  16. Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells.

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    Chung-Yi Lee

    Full Text Available BACKGROUND: Urotensin II (U-II, an 11-amino acid peptide, exerts a wide range of actions in cardiovascular systems. Interleukin-8 (IL-8 is secreted by endothelial cells, thereby enhancing endothelial cell survival, proliferation, and angiogenesis. However, the interrelationship between U-II and IL-8 as well as the detailed intracellular mechanism of U-II in vascular endothelial cells remain unclear. The aim of this study was to investigate the effect of U-II on IL-8 expression and to explore its intracellular mechanism in human umbilical vein endothelial cells. METHODS/PRINCIPAL FINDINGS: Primary human umbilical vein endothelial cells were used. Expression of IL-8 was determined by real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and luciferase reporter assay. Western blot analyses and experiments with specific inhibitors were performed to reveal the downstream signaling pathways as concerned. U-II increased the mRNA/protein levels of IL-8 in human umbilical vein endothelial cells. The U-II effects were significantly inhibited by its receptor antagonist [Orn(5]-URP. Western blot analyses and experiments with specific inhibitors indicated the involvement of phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinase in U-II-induced IL-8 expression. Luciferase reporter assay further revealed that U-II induces the transcriptional activity of IL-8. The site-directed mutagenesis indicated that the mutation of AP-1 and NF-kB binding sites reduced U-II-increased IL-8 promoter activities. Proliferation of human umbilical vein endothelial cells induced by U-II could be inhibited significantly by IL-8 RNA interference. CONCLUSION/SIGNIFICANCE: The results show that U-II induces IL-8 expression in human umbilical vein endothelial cells via p38 mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways and IL-8 is involved in the U

  17. Integration of umbilical venous and arterial Doppler flow parameters for prediction of adverse perinatal outcome

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    Hebbar Shripad

    2015-01-01

    Full Text Available Background: Quantification of umbilical vein (UV blood flow rate and umbilical artery Doppler indices might be valuable in assessing fetuses at increased risk of perinatal complications as they receive their supply of oxygen and nutrients through this vessel. Previous studies have indicated that UV blood volume flow rate to umbilical artery pulsatility index (UAPI ratio (venous arterial index [VAI] evaluates both venous and arterial arm of fetal umbilical circulation and hence, can be adopted as a screening tool in management of high risk pregnancy. Objectives: To compare umbilical VAI with adverse perinatal outcome and also to evaluate its efficacy with other flow indices in determining perinatal outcome. Materials and Methods: Various Doppler indices such as normalized blood flow rate in UV (nUV, ml/kg estimated fetal weight/min, VAI (nUV/UAPI, umbilical artery resistance index (RI, UAPI, and systolic diastolic ratio were determined in 103 pregnant women within 2 weeks of the delivery. A risk score was devised using APGAR at 5 min, birth weight, preterm delivery, fetal distress, Neonatal Intensive Care Unit (NICU care, and perinatal death and this score was correlated with antenatal Doppler findings. Results: Subjects with low VAI were found to have a greater association with intrauterine growth restricted fetuses (28.5% and low liquor (35.7%, preterm deliveries (46.4%, lower mean birth weight (2.25 kg, higher NICU admission rates (32.1%. The unfavorable score was noticed in 25.2% of the neonates. They had lower VAI (156 vs. 241, UV diameter (6.2 mm vs. 7.8 mm, UV velocity (16.2 vs. 17.8, nUV (163.7 vs. 206.4, and higher PI (1.3 vs. 0.9. A cut-off of VAI of 105 ml/kg/min had sensitivity of 86.7% and a specificity of 93.5% for predicting poor perinatal outcome. Conclusion: VAI with a cut-off of 105 ml/kg/min can be used as an additional tool along with the other conventional Doppler indices in order to predict adverse fetal outcome.

  18. An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    Rui Wang; Wei Yuan; Qiang Zhao; Peng Song; Ji Yue; Shi-De Lin; Ting-Bao Zhao

    2013-01-01

    Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus to provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivatedin vitro and the model of acute radioactive enteritis of rats was established.Then, the umbilical cord mesenchymal stem cells were injected into the rats via tail vein.Visual and histopathological changes of the experimental rats were observed.Results:After the injection, the rats in the prevention group and treatment group had remarkably better survival status than those in the control group.The histological observations revealed that the former also had better intestinal mucosa structure, more regenerative cells and stronger proliferation activity than the latter.Conclusions:Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.

  19. Illthrift in Suckling Lambs Secondary to Umbilical Infections and Possible Implication of Cryptosporidiosis as a Risk Factor

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    Nektarios D. Giadinis

    2011-01-01

    Full Text Available Illthrift was observed in 20/60 lambs aged 40–45 days in a dairy sheep flock in Greece. Cryptosporidiosis had been diagnosed and successfully treated with halofuginone lactate a month earlier. Parasitological examinations were negative for endoparasites while hematology and biochemistry were unremarkable. Necropsy of 5 lambs revealed lung and liver abscessation, presumably secondary to umbilical infections due to poor farm hygiene, though umbilical lesions were not observed. No new cases were observed following treatment of the umbilicus of newborn lambs with chlorexidine. Although umbilical infections are common, this is the first reported case of illthrift in lambs attributed to umbilical infection; illthrift may be the only clinical manifestation of such infections. The prior presence of cryptosporidiosis may have contributed to the severity of the infection through the reduction of local immunity. Recognition of this possibly underdiagnosed or underappreciated condition may improve medical, production, and welfare standards in the sheep industry.

  20. EL CONCEPTO DE VIDA «PREPERSONAL», EN EL FUTURO DE LA NATURALEZA HUMANA, DE J. HABERMAS

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    Roberto Germán Zurriaráin

    2005-01-01

    Full Text Available En este artículo se aborda el concepto de vida "prepersonal" en el libro de J. Habermas: El Futuro de la Naturaleza Humana. El autor sostiene que la vida prenatal es 2indisponible", pero no «inviolable». Habermas sostiene que el término "inviolabilidad" no es sinónimo de "indisponibilidad". El nacimiento, como acto socialmente individualizador, constituye a un organismo humano en una persona. La naturalidad del nacimiento desempeña el papel conceptualmente exigible de tal comienzo indisponible. Sin embargo, la vida humana prenatal no puede dejarse en manos de una ponderación de bienes que abra una ancha rendija a la instrumentalización de la vida. Por tanto, según Habermas, el estatuto ontológico de la vida "prepersonal", como individuo de la especie humana, radica no en lo que ya es en el vientre materno, sino en lo que será en el momento del nacimiento. El reconocimiento de la vida "prepersonal" proviene de lo que el ser humano será después del nacimiento.

  1. Papel de gestión humana en procesos de flexibilidad numérica en organizaciones colombianas

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    Ninfa Del Carmen Vega-Monsalve

    2014-12-01

    Full Text Available El fenómeno de la flexibilización numérica en Colombia -referida a la autonomía de la empresa para vincular y desvincular trabajadores de acuerdo con las demandas del mercado- nace con la llegada de algunas multinacionales que implementaban, en sus países de origen, medidas de desregularización laboral. Hoy, después de 30 años, se ha convertido en una práctica común en todo tipo de empresas. Sin embargo, no existía en el país un estudio empírico que comprendiera el papel que asume gestión humana frente al escenario de flexibilización laboral numérica. Este trabajo lo hace, desde un enfoque cualitativo de estudio de caso, de tipo descriptivo a profundidad y sobre una muestra de 22 empresas de Colombia. Los resultados mostraron que gestión humana está asumiendo un papel pasivo, en un ambiente que desvirtúa los principios de la flexibilidad contractual, plantea retos para los distintos actores y contribuye a la literatura centrada en la relación entre flexibilidad numérica y gestión humana.

  2. Paz y seguridad humana en África: una visión desde la Unión Africana

    Directory of Open Access Journals (Sweden)

    Jerónimo Delgado

    2009-11-01

    Full Text Available En este artículo se analizan las diferentes iniciativas que ha tenido el continente africano en materia de solución de conflictos y consolidación de la paz desde la perspectiva de la seguridad humana. En la primera parte, se identifican los componentes de la seguridad humana y los factores de inseguridad a los que se exponen los individuos en África, para luego examinar los avances del marco legal de la Unión Africana en la prevención de conflictos con énfasis en la seguridad de los individuos.La segunda parte contiene un estudio de las medidas enmarcadas dentro de la seguridad humana con las que cuentan los estados africanos y la comunidad internacional para la adecuada protección de los individuos, mientras se da un acercamiento entre las partes del conflicto para alcanzar el fin de las hostilidades. Finalmente, se afirma que África reconoce que la seguridad de sus ciudadanos es viable si se entienda que ésta es una responsabilidad compartida por todo el continente, en donde el individuo juega un papel central.

  3. O pensamento representacional e sua atualização nas ciências humanas

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    Eduardo Maurício Bomfim

    2012-04-01

    Full Text Available As ciências humanas ocupam um lugar particular na produção do conhecimento. Surgidas em decorrência de mudanças gerais na estrutura epistemológica e político-administrativa do século XIX, elas adquirem uma configuração específica que as localiza no cruzamento de vários outros saberes, como apontado pelo historiador Michel Foucault. Além disso, elas comportam outra peculiaridade, caracterizando-se em sua atividade por uma estreita relação com o que o filósofo Gilles Deleuze denomina de modelo da representação. A partir das análises de algumas obras destes dois pensadores, veremos como esses saberes operam uma atualização da representação por meio da normalização dos indivíduos.

  4. La ciudad desnuda. Surgimiento de una nueva condición humana

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    Michel Agier

    2002-01-01

    Full Text Available Sobre fondo de guerras, violencia y éxodos interminables, cincuenta millones de refugiados y desplazados llevan, hoy día, una vida alejada de los marcos sociales y de los espacios ordinarios durante períodos de tiempo largos (varios años, ciclos de vida completos. Se trata de nuevas formas de urbanización precaria, provisorias y/o clandestinas, marcadas por la acumulación de pérdidas materiales y sociales, por el despojo y por el rechazo. Es esta condición humana y urbana a la vez, la que queremos llamar ciudad desnuda. El artículo evoca tres maneras de observación de esta condición: las ciudades destruidas (como caso ejemplar de la destrucción original que provoca el despojo, las ciudades campamento (aglomeración provisoria de refugiados en un espacio alejado del mundo, y un fenómeno más complejo de “barbarización” de lo social, es decir, el recrudecimiento de la violencia entre la guerra y la sociedad.

  5. La construcción de esquemas: un modelo explicativo de construcción humana

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    Pilar AZNAR MINGUET

    2009-11-01

    Full Text Available Desde el alternativismo constructivista, se ha venido enfatizando el proceso activo del sujeto en la elaboración e interpretación de información, lo cual ha llevado a establecer como postulado básico el hecho de que la construcción de la realidad es un proceso activo y personal. Esta particular explicación de la configuración humana a través de la acción surge como reacción a la explicación conductista por la grave carencia que suponía, desde ésta, el hacer depender la configuración conductual de la relación funcional entre estímulos y respuestas; en esta concepción se desdeñaba el papel que desempeñaba el organismo como conductor y difusor del estímulo

  6. Homo sapiens, Homo demens e Homo degradandis: a psiquê humana e a crise ambiental

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    Alessandra Bortoni Ninis

    2012-04-01

    Full Text Available Este artigo discute a crise ambiental por meio de um diálogo entre a psicanálise, filosofia e ciências sociais. Busca-se introduzir um eixo comum de compreensão das relações entre a psiquê e a natureza, a partir de um texto reflexivo sobre a natureza humana, sua complexidade e suas sociopatias. A crise socioambiental em que vivemos é tratada a partir das seguintes proposições: (i a humanidade se distanciou da sua condição natural; (ii a humanidade pode estar psicologicamente doente; (iii a humanidade não está moralmente apta para delegar a superação da crise às futuras gerações, pois vivemos num simulacro que envolve consumismo e alienação. Conclui-se que há uma dimensão subjetiva na raiz da crise ambiental, de cuja análise depende a solução real do impasse civilizacional com o qual nos defrontamos.

  7. Seroprevalencia de hidatidosis humana en población adulta de Sancos, Ayacucho 2005

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    Vanessa García-Apaico

    2009-04-01

    Full Text Available Con el objetivo de determinar la seroprevalencia de hidatidosis humana en la población adulta de 18 a 65 años de edad residentes en el distrito de Sancos (Ayacucho en la sierra central del Perú, se desarrolló un estudio descriptivo de corte transversal durante los meses de mayo a diciembre del año 2005. El diagnóstico de hidatidosis se realizó primero con un tamizaje con ELISA y las que fueron positivas se les realizó inmunoblot. De 355 personas estudiadas, 13 presentaron serología positiva para hidatidosis, lo que representa una prevalencia de 3,7% (IC95% 1,6-5,8%, de estos, sólo dos mostraron sintomatología. El grupo de edad con mayor frecuencia de casos fue el de 30 a 50 años de edad. Los ganaderos pastores y ganaderos comerciantes fueron los grupos ocupacionales más afectados. No se encontró factores asociados con la presencia de hidatidosis.

  8. A precariedade humana e a existência estilizada Human precariousness and stylized existence

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    Rita Paiva

    2013-04-01

    Full Text Available Este artigo tematiza o desamparo vivenciado pela consciência ante a ausência de bases sólidas para seus anseios de felicidade e para suas representações simbólicas. Com esse propósito, toma como objeto de reflexão um dos ensaios filosóficos de Albert Camus, O mito de Sísifo, equacionando a possibilidade de uma ética que estilize a vida, sem que se minimize a dolorosa precariedade da existência humana. Posteriormente, em diálogo com alguns textos de M. Foucault, a reflexão procura estabelecer os vínculos possíveis entre a ética camusiana e a ética como uma estética da existência, tal como pensada entre os gregos antigos.This article discusses the helplessness experienced by the consciousness vis-à-vis the absence of solid bases for its longings for happiness and for its symbolic representations. For this purpose, the object of reflection of the article is one of Albert Camus' philosophical essays, The Myth of Sisyphus, and we inquire into the possibility of an ethics that stylizes life without minimizing the painful precariousness of human existence. Making reference to certain texts by Foucault, we attempt to establish possible connections between Camus' ethics and an ethics of the aesthetics of existence as found in the thinkers of ancient Greece.

  9. Emocionalidad y moralidad en el debate sobre la clonación humana

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    Santiago Gabriel Calise

    2015-01-01

    Full Text Available El artículo que se presenta a continuación está dedicado al análisis de las emociones desplegadas en el debate bioético en torno del tema de la clonación humana. Al igual que respecto de otras innovaciones científicas que generan polémica, las posiciones suelen tender hacia el miedo o la esperanza. Aquí, a través de los conceptos de P. Livet, se pondrá el acento en el análisis de la relación entre las emociones desplegadas, los valores que estas emociones revelan y el proceso de revisión de las últimas. También será esencial analizar si realmente existe coherencia entre las emociones expresadas y los valores defendidos (identidad, dignidad, etc.. Ante su falta, se hablará, como señala Ogien, de pánico moral, situación en la cual, la puesta en escena de grandes reglas morales universales y de profundos sentimientos de indignación, esconde el rechazo a ir al fondo de las propias razones morales, por miedo a tener que admitir que los propios prejuicios se encuentran infundados.

  10. Memória humana e teatro Human memory and theater

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    Edna de Souza Alves

    2001-01-01

    Full Text Available A memória humana é essencial para a atividade teatral. Isso por um motivo óbvio: é ela que possibilita aos atores gravarem suas falas e ao público compreender a mensagem passada pela peça. Neste trabalho, investigamos as noções de memória propostas por Descartes, Hume e Kohonen. Para eles, a memória é imprescindível na obtenção e desenvolvimento do conhecimento. A nosso ver, o estudo da memória é de grande importância para o teatro, à medida que este não seria possível sem aquela.The human memory plays an essential role in theatrical activity because it makes it possible that the actors record their lines and the public understands the message transmitted in the play. In this work, the notion of memory proposed by Descartes, Hume and Kohonen are investigated. For those thinkers, memory is indispensable to obtain and develop knowledge. In our opinion, the study of memory is of great importance for the theater, because the theater doesn't exist without memory.

  11. Exposição humana a trialometanos presentes em água tratada

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    Maria Y Tominaga

    1999-08-01

    Full Text Available Realizou-se uma revisão bibliográfica do período de 1974-1998, no MEDLINE, sobre compostos orgânicos halogenados derivados de hidrocarbonetos denominados de trialometanos. Muitos deles, reconhecidamente carcinogênicos para diferentes espécies animais, podem ser encontrados freqüentemente, inclusive entre nós, em águas tratadas e enviadas à população urbana. É o caso de compostos como o clorofórmio, bromodiclorometano, clorodibromometano e bromofórmio, resultantes da halogenação de precursores, principalmente substâncias húmicas e fúlvicas presentes na água que será tratada (clorada. Assim, descreve-se sua formação, fontes de exposição humana bem como os aspectos toxicológicos de maior importância: disposição cinética e espectro dos efeitos tóxicos (carcinogênicos, mutagênicos e teratogênicos decorrentes de exposições a longo prazo e baixas concentrações. Níveis seguros de exposição propostos são também fornecidos.

  12. La Bioética. Terreno de encuentro entre ciencias naturales y ciencias humanas

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    Carla Faralli

    2014-01-01

    Full Text Available El artículo reflexiona sobre el contexto de la bioética frente al actual despliegue humano. A partir del quehacer de la investigación cientí- fica y tecnológica, se establece este quehacer como terreno de encuetro entre dos perspectivas del conocimiento: lo científico/tecnológico y lo humanístico. De tal unidad surge el nombre de esta práxis intelectual, como una de las disciplinas más controvertidas que hayan emergido al fragor de las polémicas traidas al mundo social por la experimentación y el desarrollo científico desde los años Setenta del Siglo XX. La bioética se concibe como clarificadora de las cuestiones éticas traidas por la intervención de la ciencia y la tecnología a la vida humana y ecosistemas. Es un área no disciplinaria donde concurren diversos quehaceres de la vida y de la práxis humanística, constituyéndose así en un lugar propio para la reflexión actual sobre el conocimiento. Se concluye que es terreno común de todas las disciplinas que impactan al hombre y su entorno.

  13. Disfunción tiroidea en adultos infectados por el virus de inmunodeficiencia humana

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    Erika Abelleira

    2014-08-01

    Full Text Available Los pacientes con infección por el virus de inmunodeficiencia humana (HIV tienen una mayor prevalencia de disfunción tiroidea cuando se los compara con la población general. Las manifestaciones más frecuentemente observadas son: el síndrome del eutiroideo enfermo, la enfermedad de Graves y el hipotiroidismo subclínico. La relación entre el uso de la terapia antirretroviral y el incremento en la prevalencia de alteraciones tiroideas fue demostrada en varias series de pacientes. La enfermedad de Graves se reconoce claramente como una consecuencia del síndrome de restitución inmune. Además, existen estudios que sugieren una relación entre hipotiroidismo y el uso de inhibidores nucleósidos de la transcriptasa reversa, en particular estavudina y el inhibidor no nucleósido de la transcriptasa reversa efavirenz. Nuevos estudios podrán aportar evidencia adicional sobre la necesidad de evaluaciones rutinarias de la función tiroidea en pacientes infectados por HIV.

  14. Uma abordagem naturalista da consciência humana A naturalistic approach to human consciousness

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    Alfredo Pereira Júnior

    2003-01-01

    Full Text Available Abordo neste trabalho alguns dos principais problemas filosóficos concernentes a uma concepção naturalista da consciência humana, assim como algumas evidências disponíveis na neuropsicologia e neurofisiologia, sobre a relação entre atividade cerebral e experiência consciente. Inicialmente faço uma revisão sobre a definição de "consciência", seu estatuto filosófico e relação com os processos emocionais, e proponho três condições para sua atribuição a um sistema físico. Em seguida, identifico diferentes modalidades de consciência, e seus correlatos cerebrais em diferentes escalas espaciais e temporais. Finalmente, discuto possíveis mecanismos biofísicos subjacentes aos processos conscientes.This essay discusses some central philosophical problems concerning the naturalistic concept of consciousness, as well as evidence from neuropsychology and neurophysiology regarding the relation of brain activity and conscious experience. Initially I review the problem of defining "consciousness", the philosophical approach to the phenomenon and its relation to emotional processes. The next step is a proposal of three conditions for the attribution of consciousness to physical systems. In the following section, I identify different modalities of consciousness and their respective neural correlates in different spatial and temporal scales. Finally, I discuss possible biophysical mechanisms underlying conscious processing.

  15. Comunicación intercultural y ciencias humanas: una forma especial de encuentro

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    Solange Cárcamo Landero

    2009-07-01

    Full Text Available La comunicación intercultural, considerada como vivencia y experiencia auténtica de apertura hacia los Otros, es proyecto y método para la búsqueda de lo intercultural. Ella permite situar nuestras prácticas epistemológicas y metodológicas en el horizonte de una ciencia de la conversación profunda; cuyo desarrollo nos exige una redescripción holista de nuestras experiencias científicas para hacerlas menos etnocentristas. En este sentido, aquí ofrecemos una reflexión que conjuga el pensamiento de autores diversos (Panikkar, 2002; Taylor, 2005; Jaspers, 1980; Freire, 2003; Recasens, 2007; entre otros, para llegar a establecer como hipótesis transitoria que: la apertura intercultural de las ciencias humanas requiere de una epistemología de la concordia coherente con una metodología de la conversación a profundidad; que aquí concebimos como necesariamente intercultural.

  16. Las raíces de la identidad: los dispositivos de la reflexividad social humana, su evolución y sus efectos

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    Pablo Navarro

    2009-03-01

    Full Text Available Este artículo explora algunos de los componentes de la identidad social humana. Describe esa identidad como un mecanismo auto-reflectivo que ha evolucionado históricamente de forma paralela al desarrollo estructural de las sociedades humanas. Los diferentes perfiles que adopta la identidad social humana se corresponden con los diversos mecanismos de reflexividad social que desarrollan esas sociedades. El dispositivo reflexivo original de las sociedades humanas es la reflexividad reflectiva, cuyo instrumento es la conciencia autoconsciente y heteroconsciente de los individuos. Por medio de este dispositivo, cada individuo es capaz de crear elaborados mapas sociales de su entorno. Pero además de este mecanismo primigenio de la socialidad humana, y en el transcurso de la evolución social, han surgido otros mecanismos de naturaleza no reflectiva, que se basan no ya en la interacción consciente, sino en una interacción de carácter intencionalmente disipativo. Se trata de una interacción que se genera, no a partir de alguna forma de confluencia intencional entre los actores, sino como consecuencia de una peculiar trabazón entre algunas de las consecuencias no queridas de sus acciones. Esta reflexividad disipativa, ejemplificada por las relaciones de mercado, se entrelaza con la susodicha reflexividad reflectiva y conjuntamente determinan la clase de identidad social humana que es característica de las sociedades modernas.

  17. The Impact of Umbilical Blood Flow Regulation on Fetal Development Differs in Diabetic and Non-Diabetic Pregnancy

    OpenAIRE

    Jian Li; You-Peng Chen; Yun-Peng Dong; Cai-Hong Yu; Yong-Ping Lu; Xiao-Min Xiao; Berthold Hocher

    2014-01-01

    Background/Aims: Diabetes is well-known to influence endothelial function. Endothelial function and blood flow regulation might be different in diabetic and non-diabetic pregnancy. However, the impact of umbilical blood flow regulation in gestational diabetes on fetal development is unknown so far. Methods: In a prospective birth cohort study, we analyzed the association of the umbilical artery Doppler indices (pulsatility index, resistance index and systolic/diastolic ratio) and fetal size m...

  18. A "Kane's Dynamics" Model for the Active Rack Isolation System. Part 3; Addition of Umbilicals to the Nonlinear Model

    Science.gov (United States)

    Rupert, J. K.; Hampton, R. D.; Beech, G. S.

    2005-01-01

    In the late 1980s, microgravity researchers began to voice their concern that umbilical-transmitted energy could significantly degrade the acceleration environment of microgravity space science experiments onboard manned spacecraft. Since umbilicals are necessary for many experiments, control designers began to seek ways to compensate for these "indirect" disturbances. Hampton, et al., used the Kane s method to develop a model of the active rack isolation system (ARIS) that includes (1) actuator control forces, (2) direct disturbance forces, and (3) indirect, actuator-transmitted disturbances. Their model does not, however, include the indirect, umbilical-transmitted disturbances. Since the umbilical stiffnesses are not negligible, these indirect disturbances must be included in the model. Until the umbilicals have been appropriately included, the model will be incomplete. This Technical Memorandum presents a nonlinear model of ARIS with umbilicals included. Model verification was achieved by utilizing two commercial-off-the-shelf software tools. Various forces and moments were applied to the model to yield simulated responses of the system. Plots of the simulation results show how various critical points on an ARIS-outfitted international standard payload rack behave under the application of direct disturbances, indirect disturbances, and control forces. Simulations also show system response to a variety of initial conditions.

  19. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells.

    Science.gov (United States)

    Sanberg, Paul R; Eve, David J; Willing, Alison E; Garbuzova-Davis, Svitlana; Tan, Jun; Sanberg, Cyndy D; Allickson, Julie G; Cruz, L Eduardo; Borlongan, Cesar V

    2011-01-01

    Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells. These cells are relatively easy to obtain, appear to be pluripotent, and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells.

  20. Enhancing endogenous stem cells in the newbornvia delayed umbilical cord clamping

    Institute of Scientific and Technical Information of China (English)

    Christopher Lawton; Sandra Acosta; Nate Watson; Chiara Gonzales-Portillo; hTeo Diamandis; Naoki Tajiri; Yuji Kaneko; Paul R. Sanberg; Cesar V. Borlongan

    2015-01-01

    There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal beneifts including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deifciency anemia in term infants. Human umbilical cord blood con-tains signiifcant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it en-hances blood lfow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant’s susceptibility to both neonatal and age-related diseases.

  1. Omentum in the Pediatric Umbilical Hernia: Is It a Potential Alarm for the Appearance of Complications?

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    Xenophon Sinopidis

    2012-01-01

    Full Text Available Umbilical hernia is a common benign condition which resolves spontaneously during the first five years of life. However, in certain cases there are some characteristics which may be indicative of a different prognostic approach, as they increase the possibility of complications. The two cases of umbilical hernia that we describe here were treated operatively and revealed the presence of strangulated and adhered omentum, respectively. Reflecting on the adhesive properties of the omentum, we hypothesized that this may occur more often than it is believed, especially in those cases that are described as recurrent symptomatic herniations. In such cases, there should be increased alert for the possibility of complications during the period of the conservative expectance for resolution.

  2. Omentum in the pediatric umbilical hernia: is it a potential alarm for the appearance of complications?

    Science.gov (United States)

    Sinopidis, Xenophon; Panagidis, Antonios; Alexopoulos, Vasileios; Karatza, Ageliki; Mitropoulou, Konstantina; Varvarigou, Anastasia; Georgiou, George

    2012-01-01

    Umbilical hernia is a common benign condition which resolves spontaneously during the first five years of life. However, in certain cases there are some characteristics which may be indicative of a different prognostic approach, as they increase the possibility of complications. The two cases of umbilical hernia that we describe here were treated operatively and revealed the presence of strangulated and adhered omentum, respectively. Reflecting on the adhesive properties of the omentum, we hypothesized that this may occur more often than it is believed, especially in those cases that are described as recurrent symptomatic herniations. In such cases, there should be increased alert for the possibility of complications during the period of the conservative expectance for resolution.

  3. Correlations between stress hormone levels in umbilical cord blood and duration of delivery.

    Science.gov (United States)

    Sano, Yoko; Doi, Takayuki; Kikuchi, Suguru; Kawai, Kennta; Tanaka, Minoru

    2015-07-01

    Correlations between umbilical cord blood concentration of stress response hormone cortisol and prolactin, and delivery duration were examined. Thirty-three cases were selected in which both mothers and neonates were healthy, and the neonates were delivered at full term. The umbilical cord blood was collected at the time of delivery and concentrations of cortisol and prolactin were measured. The cortisol level was significantly higher after vacuum-assisted delivery than after spontaneous delivery (p=0.044). Significant positive correlations (p=0.0289) were observed between cortisol level and delivery duration. In particular, the duration of the second stage of delivery showed stronger positive correlation (p=0.0304) with the cortisol level. The prolactin level showed weak correlation with the duration of full delivery and the second stage of delivery. The findings suggest that foetuses may respond to stress by uterine contraction during delivery.

  4. Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury

    Institute of Scientific and Technical Information of China (English)

    CAO Fu-jiang; FENG Shi-qing

    2009-01-01

    Objective To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury, Data sources Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline. Study selection Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identifiied arises 51 were selected that specifically addressed the stated purpose. Results Recent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies. Conclusions Human umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.

  5. Gastro-umbilical fistula as a rare complication of benign gastric ulcer perforation: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ju Young; Jang, Kyung Mi; Yoon, Hoi Soo; Kim, Min Jeong; Lee, Kwan Seop; Lee, Yul; Bae, Sang Hoon [College of Medicine, Hallym University, Anyang (Korea, Republic of)

    2007-11-15

    As fistula occurring between the stomach and other abdominal internal organs or to the surface of the body is usually encountered as a complication of stomach cancer or colon cancer, peptic ulcer disease, or other variable causes. The most common type of gastric fistula is a gastro-colic fistula that is mainly found as a complication of a gastric carcinoma or of a carcinoma of the transverse colon invading each other. Sometimes, a benign gastric ulcer perforation also can cause a gastro-colic fistula. However, as far as we know, a fistula occurring between the stomach and the umbilicus has not been reported. Here we present a case report of a gastro-umbilical fistula in a young woman that manifested as a umbilical discharge.

  6. Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro

    OpenAIRE

    Mohr, Thomas; Desser, Lucia

    2013-01-01

    Background Vascular endothelial growth factor (VEGF) is a key regulator of physiologic and pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. It is known that cysteine proteases from plants, like bromelain and papain are capable to suppress inflammatory activation. Recent studies have demonstrated that they may interfere with angiogenesis related pathways as well. The aim of this study was to investigate the anti-angiogenic effects of papain on human umbilical vein e...

  7. Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration

    OpenAIRE

    Yuanwei Chen; Yongchun Yu; Lin Chen; Lanfeng Ye; Junhui Cui; Quan Sun; Kaide Li; Zhiyong Li; Lei Liu

    2015-01-01

    Tooth regeneration is considered to be an optimistic approach to replace current treatments for tooth loss. It is important to determine the most suitable seed cells for tooth regeneration. Recently, human umbilical cord mesenchymal stem cells (hUCMSCs) have been regarded as a promising candidate for tissue regeneration. However, it has not been reported whether hUCMSCs can be employed in tooth regeneration. Here, we report that hUCMSCs can be induced into odontoblast-like cells in vitro and ...

  8. The Application of Umbilical Cord Blood Cells in the Treatment of Diabetes Mellitus

    OpenAIRE

    Koblas, Tomas; Harman, S. Mitchell; Saudek, Frantisek

    2005-01-01

    In recent years, human umbilical cord blood (HUCB) has emerged as an attractive tool for cell-based therapy. Although at present the clinical application of HUCB is limited to the fields of hematology and oncology, a rising number of studies show potential for further application in the treatment of non-hematopoietic diseases. HUCB, with its real abundance, simple collection procedure and no serious ethical dilemmas, represents a valuable alternative to the use of other stem cell sources. The...

  9. A 26-Year-Old Retained Demised Abdominal Pregnancy Presenting with Umbilical Fistula

    Directory of Open Access Journals (Sweden)

    Nnadi Daniel

    2014-01-01

    Full Text Available This is a report on a 72-year-old postmenopausal woman who presented with passage of fetal bones through an umbilical fistula. She was diagnosed as a case of demised abdominal pregnancy, which had been retained for 26 years. She subsequently had exploratory laparotomy, evacuation of the abdominal pregnancy, hysterectomy, and bowel resection. The patient’s condition remained unstable throughout the postoperative period and she died from septicemia on the eleventh day.

  10. Effects of Hypoxia and Chitosan on Equine Umbilical Cord-Derived Mesenchymal Stem Cells

    OpenAIRE

    Griffon, D. J.; Cho, J.; Wagner, J. R.; Charavaryamath, C.; Wei, J.; Wagoner Johnson, A.

    2016-01-01

    Chitosan opens new perspectives in regenerative medicine as it enhances the properties of mesenchymal stem cells (MSCs) through formation of spheroids. Hypoxia has also been proposed to enhance stemness and survival of MSCs after in vivo implantation. These characteristics are relevant to the development of an off-the-shelf source of allogenic cells for regenerative therapy of tendinopathies. Umbilical cord-derived MSCs (UCM-MSCs) offer an abundant source of immature and immunoprivileged stem...

  11. Molecular characterization of microbial contaminants isolated from Umbilical Cord Blood Units for transplant.

    Science.gov (United States)

    Bello-López, Juan Manuel; Noguerón-Silva, Jorge; Castañeda-Sánchez, Jorge Ismael; Rojo-Medina, Julieta

    2015-01-01

    Disposal of Umbilical Cord Blood Units due to microbial contamination is a major problem in Cord Blood Banks worldwide as it reduces the number of units available for transplantation. Additionally, economic losses are generated as result of resources and infrastructure used to obtain such units. Umbilical Cord Blood Units that showed initial microbial contamination were subject to strains isolation, identification, and characterization by sequencing the 16S rRNA gene and Enterobacterial Repetitive Intergenic Consensus (ERIC-PCR). Moreover, tests of antimicrobial resistance/sensitivity and phenotypic activities that may play an important role in microbial infection were performed. Microbial contamination was detected in 120 Umbilical Cord Blood Units (2.31%) in the period from 2003 to 2013. The most frequently isolated strains were Enterococcus faecium, followed by Staphylococcus epidermidis, Escherichia coli, Enterococcus faecalis, Staphylococcus haemoliticus, Klebsiella pneumoniae, Enterococcus durans, Lactobacillus helveticus, Enterococcus hiriae and Roseomonas genomospecies 5. The ERIC-PCR assays revealed a wide genetic diversity in some strains although belonging to the same genus and specie, indicating different sources of contamination. Broad-spectrum penicillins, third generation cephalosporins, aminoglycosides, and fluoroquinolones showed lower inhibitory activity on the tested strains. All strains were proteolytic, 67.69% were amylase-positive, 27.6% hemolysis-positive, and 34.71% nuclease-positive. The most common sources of contamination were: vaginal flora, digestive tract, and skin flora, highlighting the need for staff training in good manufacturing practices in collection SCU since all contaminants identified are part of the microbial flora of the donors. Implications and consequences in the therapeutic use of Umbilical Cord Blood Units for transplantation contaminated by multiresistant bacteria in immunocompromised patients are discussed. PMID

  12. Human umbilical cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide intoxication

    Directory of Open Access Journals (Sweden)

    Gong D

    2013-08-01

    Full Text Available Dianrong Gong,1 Haiyan Yu,1 Weihua Wang,2 Haixin Yang,1 Fabin Han1,21Department of Neurology, 2Centre for Stem Cells and Regenerative Medicine, Liaocheng People's Hospital, The Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People's Republic of ChinaAbstract: Stem cell transplantation is one of the potential treatments for neurological disorders. Since human umbilical cord stem cells have been shown to provide neuroprotection and promote neural regeneration, we have attempted to transplant the human umbilical cord blood mononuclear cells (hUCB-MNCs to treat patients with delayed encephalopathy after carbon monoxide intoxication (DEACOI. The hUCB-MNCs were isolated from fresh umbilical cord blood and were given to patients subarachnoidally. Physical examinations, mini-mental state examination scores, and computed tomography scans were used to evaluate the improvement of symptoms, signs, and pathological changes of the patient's brain before and after hUCB-MNC transplantation. A total of 12 patients with DEACOI were treated with hUCB-MNCs in this study. We found that most of the patients have shown significant improvements in movement, behavior, and cognitive function, and improved brain images in 1–4 months from the first transplantation of hUCB-MNCs. None of these patients have been observed to have any severe adverse effects. Our study suggests that the hUCB-MNC transplantation may be a safe and effective treatment for DEACOI. Further studies and clinical trials with more cases, using more systematic scoring methods, are needed to evaluate brain structural and functional improvements in patients with DEACOI after hUCB-MNC therapy.Keywords: human umbilical cord blood mononuclear cells, transplantation, delayed encephalopathy after carbon monoxide intoxication, MMSE

  13. Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells

    Directory of Open Access Journals (Sweden)

    Peggy Matz

    2015-11-01

    Full Text Available Human umbilical vein endothelial cells (HUVECs were used to generate the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro. The transcriptome profile of epiHUVEC and the human embryonic stem cell line — H1 have a Pearson correlation of 0.899.

  14. Fetal cerebral-umbilical Doppler ratio in prediction of fetal distress in patients with preeclampsia

    OpenAIRE

    Jurišić Aleksandar; Jurišić Žaklina; Pažin Vladimir; Vasiljević Mladenko; Janković-Ražnatović Svetlana; Dragojević-Dikić Svetlana

    2010-01-01

    Bacground/Aim. The use of color Doppler ultrasonography provides noninvasive observation, confirmation and quantification of pathophysiological processes in fetoplacental circulation in pregnant patients. By blood vessel mapping and the obtained waves spectral analysis it is possible to evaluate vascular resistency of the fetus blood vessels. The aim of the study was to evaluate cerebral-umbilical pulsatility index ratio in fetal circulation in prediction of fetal distress in patients with pr...

  15. Time related variations in stem cell harvesting of umbilical cord blood

    OpenAIRE

    Gianluigi Mazzoccoli; Giuseppe Miscio; Andrea Fontana; Massimiliano Copetti; Massimo Francavilla; Alberto Bosi; Federico Perfetto; Alice Valoriani; Angelo De Cata; Michele Santodirocco; Angela Totaro; Rosa Rubino; Lazzaro di Mauro; Roberto Tarquini

    2016-01-01

    Umbilical cord blood (UCB) contains hematopoietic stem cells and multipotent mesenchymal cells useful for treatment in malignant/nonmalignant hematologic-immunologic diseases and regenerative medicine. Transplantation outcome is correlated with cord blood volume (CBV), number of total nucleated cells (TNC), CD34+ progenitor cells and colony forming units in UCB donations. Several studies have addressed the role of maternal/neonatal factors associated with the hematopoietic reconstruction pote...

  16. Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury

    OpenAIRE

    Yuanyuan Zhao; Xiaoxian Sun; Wenming Cao; Jie Ma; Li Sun; Hui Qian; Wei Zhu; Wenrong Xu

    2015-01-01

    This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined through nanoparticle tracking analysis. Exosomes (400 μg protein) were intravenously administrated immediately following ligation of the left anterior descending (LAD) coronary arte...

  17. Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells.

    Science.gov (United States)

    Kadam, Sachin S; Bhonde, Ramesh R

    2010-01-01

    The scarcity of islets for transplantation calls for an alternative sources of islets. The human umbilical cord has been shown to be a reservoir of multipotent stem cells with capacity to differentiate into ectodermal, mesodermal and endodermal lineages. The present investigation deals with isolation and characterization of mesenchymal stem sells (MSC) derived from human umbilical cord and their differentiation into functional islets. Since these MSCs were found to constitutively express nestin we hypothesized that these would be ideal candidates for islet neogenesis without any further manipulation. Human umbilical cord matrix stem cells (hUCMSCs) were found to express CD29, CD44, CD73, CD90, CD105, smooth muscle actin, nestin, vimentin, proliferation marker Ki67 and embryonic markers Oct4, SSEA4. These were found to be negative for CD33, CD34, CD45 and HLA DR. Human UCMSCs exhibited high proliferating capacity for extended period indicating potential for scaling up. When subjected to a cocktail of specific differentiating factors, these cells differentiated into fat, cartilage, bone, neurons and islet like clusters (ILCs). These ILCs stained positive for diphenylthiocarbazone (DTZ) and expressed human C-peptide, insulin and glucagon. Real time qPCR analysis of newly generated islets further demonstrated abundance of Pdx-1, Ngn3, insulin, glucagon and somatostatin transcripts. On transplantation in experimental diabetic mice these ILCs restored normoglycemia, body weight and exhibited normal glucose tolerance test indicating their functional status. Thus, the present study demonstrates potential of constitutively expressing nestin positive progenitor from umbilical cord as a novel source for islet neogenesis and their usage in cell replacement therapy for diabetes.

  18. Molecular characterization of microbial contaminants isolated from Umbilical Cord Blood Units for transplant

    Directory of Open Access Journals (Sweden)

    Juan Manuel Bello-López

    2015-12-01

    Full Text Available ABSTRACT Disposal of Umbilical Cord Blood Units due to microbial contamination is a major problem in Cord Blood Banks worldwide as it reduces the number of units available for transplantation. Additionally, economic losses are generated as result of resources and infrastructure used to obtain such units. Umbilical Cord Blood Units that showed initial microbial contamination were subject to strains isolation, identification, and characterization by sequencing the 16S rRNA gene and Enterobacterial Repetitive Intergenic Consensus (ERIC-PCR. Moreover, tests of antimicrobial resistance/sensitivity and phenotypic activities that may play an important role in microbial infection were performed. Microbial contamination was detected in 120 Umbilical Cord Blood Units (2.31% in the period from 2003 to 2013. The most frequently isolated strains were Enterococcus faecium, followed by Staphylococcus epidermidis, Escherichia coli, Enterococcus faecalis, Staphylococcus haemoliticus, Klebsiella pneumoniae, Enterococcus durans, Lactobacillus helveticus, Enterococcus hiriae and Roseomonas genomospecies 5. The ERIC-PCR assays revealed a wide genetic diversity in some strains although belonging to the same genus and specie, indicating different sources of contamination. Broad-spectrum penicillins, third generation cephalosporins, aminoglycosides, and fluoroquinolones showed lower inhibitory activity on the tested strains. All strains were proteolytic, 67.69% were amylase-positive, 27.6% hemolysis-positive, and 34.71% nuclease-positive. The most common sources of contamination were: vaginal flora, digestive tract, and skin flora, highlighting the need for staff training in good manufacturing practices in collection SCU since all contaminants identified are part of the microbial flora of the donors. Implications and consequences in the therapeutic use of Umbilical Cord Blood Units for transplantation contaminated by multiresistant bacteria in immunocompromised

  19. Lipoabdominoplastia con desinserción umbilical y despegamiento abdominal reducido Lipoabdominoplastia com desinserção umbilical e descolamento reduzido Lipoabdominoplasty with umbilical detachment and reduced abdominal undermining

    Directory of Open Access Journals (Sweden)

    F. A. M. Cido Carvalho

    2008-12-01

    Full Text Available Presentamos una combinación de procedimientos quirúrgicos para el tratamiento del exceso de volumen abdominal con flacidez moderada, utilizando una miniabdominoplastia con despegamiento y desinserción umbilical, asociada a liposucción. La indicación de la técnica se restringe a aquellos casos en los que la liposucción aislada provocaría un agravamiento de la flacidez, mientras que una abdominoplastia clásica implicaría una resección exagerada de piel o la necesidad de dejar una pequeña cicatriz vertical. Una miniabdominplastia trataría solamente la flacidez del abdomen inferior, dejando un exceso de piel en la región supraumbilical. La combinación de liposucción amplia y despegamiento controlado del área central del abdomen, asociada a una desinserción umbilical y su posterior reinserción unos 2 a 4 cm más abajo, nos permite lograr una completa plicatura de los rectos abdominales, con una buena resección del exceso cutáneo del abdomen inferior, además de un tratamiento adecuado de la flacidez moderada del abdomen superior.We present a combination of procedures for the treatment of the abdominal volume excess with moderate skin excess, using lipoabdominoplasty with detachment of the navel. Indications are restricted to those cases where the isolated suction-assisted lipoctomy (SAL would take to the worsening of the skin flaccidity, while the full abdominoplasty would imply in exaggerated excision of the skin or presence of small vertical scar. The miniabdominoplasty more frequently used would only treat the flaccidity about the inferior abdomen, leaving skin excess in the upper abdomen area. The combination of wide suctionassisted lipectomy with undermining in the central area of the abdomen, with umbilical detachment and its posterior new implantation about 2 to 5 cm lower, allows a complete plication of the abdominal rectums, with good excision of the skin excess of the inferior abdomen, besides the treatment of the

  20. Osteogenic potential of human umbilical cord-derived mesenchymal stromal cells cultured with umbilical cord blood-derived fibrin: a preliminary study.

    Science.gov (United States)

    Baba, Kyoko; Yamazaki, Yasuharu; Ishiguro, Masashi; Kumazawa, Kenichi; Aoyagi, Kazuya; Ikemoto, Shigehiro; Takeda, Akira; Uchinuma, Eiju

    2013-12-01

    This study examined the potential for osteogenesis via regenerative medicine using autologous tissues (umbilical cord (UC) and umbilical cord blood (UCB)) in nude mice. The study was designed to provide the three elements required for regenerative medicine (cell, scaffold, and growth factor) and autoserum for culture by means of autologous tissues. Mesenchymal stromal cells were obtained from UC (UC-MSCs). Fibrin, platelet-rich-plasma, and autoserum were obtained from UCB as scaffold, growth factor and serum for culture respectively. UC-MSCs were obtained from Wharton jelly and cultured with UCB-derived fibrin (UCB-fibrin) for 3-4 weeks to induce their differentiation into osteoblasts. They were implanted subcutaneously into the dorsum of male nude mice for 6 weeks prior to undergoing assessment. The assessments performed were haematoxylin and eosin, and alizarin red staining, immunohistochemical staining of human mitochondria, scanning electron microscopy, scanning electron microscopy with energy dispersive X-ray spectrometry and real-time reverse transcriptase-polymerase chain reaction to assess the expressions of osteoblast markers. Consequently, the differentiation of UC-MSCs into osteoblasts and the production of hydroxyapatite were verified. This study suggested the possible formation of bone tissue using biomedical materials obtained from UC and UCB.

  1. Prospective Observational Study of Single-Site Multiport Per-umbilical Laparoscopic Endosurgery versus Conventional Multiport Laparoscopic Cholecystectomy: Critical Appraisal of a Unique Umbilical Approach

    Directory of Open Access Journals (Sweden)

    Priyadarshan Anand Jategaonkar

    2014-01-01

    Full Text Available Purpose. This prospective observational study compares an innovative approach of Single-Site Multi-Port Per-umbilical Laparoscopic Endo-surgery (SSMPPLE cholecystectomy with the gold standard—Conventional Multi-port Laparoscopic Cholecystectomy (CMLC—to assess the feasibility and efficacy of the former. Methods. In all, 646 patients were studied. SSMPPLE cholecystectomy utilized three ports inserted through three independent mini-incisions at the umbilicus. Only the day-to-day rigid laparoscopic instruments were used in all cases. The SSMPPLE cholecystectomy group had 320 patients and the CMLC group had 326 patients. The outcomes were statistically compared. Results. SSMPPLE cholecystectomy had average operative time of 43.8 min and blood loss of 9.4 mL. Their duration of hospitalization was 1.3 days (range, 1–5. Six patients (1.9% of this group were converted to CMLC. Eleven patients had controlled gallbladder perforations at dissection. The Visual Analogue Scores for pain on postoperative days 0 and 7, the operative time, and the scar grades were significantly better for SSMPPLE than CMLC. However, umbilical sepsis and seroma outcomes were similar. We had no bile-duct injuries or port-site hernias in this study. Conclusion. SSMPPLE cholecystectomy approach complies with the principles of laparoscopic triangulation; it seems feasible and safe method of minimally invasive cholecystectomy. Overall, it has a potential to emerge as an economically viable alternative to single-port surgery.

  2. Non-gated fetal MRI of umbilical blood flow in an acardiac twin

    Energy Technology Data Exchange (ETDEWEB)

    Hata, Nobuhiko [University of Tokyo, Graduate School of Information Science and Technology, Tokyo (Japan); Brigham and Women' s Hospital, Department of Radiology, Boston, MA (United States); Wada, Toru [University of Tokyo, Graduate School of Information Science and Technology, Tokyo (Japan); Kashima, Kyoko; Okada, Yoshiyuki [National Center for Child Health and Development, Department of Radiology, Tokyo (Japan); Unno, Nobuya [Nagano Children' s Hospital, Center for Perinatal Medicine, Nagano (Japan); Kitagawa, Michihiro [National Center for Child Health and Development, Department of Prenatal Medicine and Maternal Care, Tokyo (Japan); Chiba, Toshio [National Center for Child Health and Development, Department of Strategic Medicine, Tokyo (Japan)

    2005-08-01

    Currently, the standard method of diagnosis of twin reversed arterial perfusion (TRAP) sequence is ultrasound imaging. The use of MRI for flow visualization may be a useful adjunct to US imaging for assessing the presence of retrograde blood flow in the acardiac fetus and/or umbilical artery. The technical challenge in fetal MRI flow imaging, however, is that fetal electrocardiogram (ECG) monitoring required for flow imaging is currently unavailable in the MRI scanner. A non-gated MRI flow imaging technique that requires no ECG monitoring was developed using the t-test to detect blood flow in 20 slices of phase-contrast MRI images randomly scanned at the same location over multiple cardiac cycles. A feasibility study was performed in a 24-week acardiac twin that showed no umbilical flow sonographically. Non-gated MRI flow images clearly indicated the presence of blood flow in the umbilical artery to the acardiac twin; however, there was no blood flow beyond the abdomen. This study leads us to conjecture that non-gated MRI flow imaging is sensitive in detecting low-range blood flow velocity and can be an adjunct to Doppler US imaging. (orig.)

  3. The value of ultrasonography in the diagnosis of portal vein thrombosis by umbilical venous catheterization

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwang Keun; Kim, Young Tong; Kim, Il Young [Chonan Hospital, Soonchunhyang University, Chonan (Korea, Republic of)

    2000-12-15

    To evaluate the usefulness of ultrasonography for diagnosis of portal vein thrombosis (PVT) associated with the umbilical venous catheterization (UVC). We reviewed the abnormal ultrasonography of 54 patients with UVC. We observed echogenic thrombus in the portal vein by ultrasonography which has a 5-10 MHz linear transducer. We evaluated the frequency of PVT, the relationship between PVT and duration of UVC, and the location of catheter tip (Group I (n=41): above the diaphragm, Group II (n=9): between the diaphragm and the liver, Group III (n=4): below the liver), the location of thrombus on US, and the change of PVT on the follow-up ultrasonography. PVT was identified in the 7 neonates (13%) among the 54 neonates with UVC. The frequency of PVT was 5% on group I, 45% on group II and 25% on group III. The 6 cases among the 7 cases(86%) of PVT were localized to the umbilical portion of the left portal vein, and there were completely resolved (n=4) or regressed (n=1) on the follow-up ultrasonography(n=5). Remaining one case of PVT was located in the right, left, and main portal veins with collateral formation, and cavernous transformation occurred on the follow-up. Most PVTs by UVC are localized to the umbilical portion of left portal vein. Ultrasonography is a useful modality to diagnose PVT by UVC.

  4. Therapeutic potential of umbilical cord blood cells for type 1 diabetes mellitus.

    Science.gov (United States)

    He, Binbin; Li, Xia; Yu, Haibo; Zhou, Zhiguang

    2015-11-01

    Type 1 diabetes mellitus (T1DM) is a chronic disorder that results from autoimmune-mediated destruction of pancreatic islet β-cells. However, to date, no conventional intervention has successfully treated the disease. The optimal therapeutic method for T1DM should effectively control the autoimmunity, restore immune homeostasis, preserve residual β-cells, reverse β-cell destruction, and protect the regenerated insulin-producing cells against re-attack. Umbilical cord blood is rich in regulatory T (T(reg)) cells and multiple types of stem cells that exhibit immunomodulating potential and hold promise in their ability to restore peripheral tolerance towards pancreatic islet β-cells through remodeling of immune responses and suppression of autoreactive T cells. Recently, reinfusion of autologous umbilical cord blood or immune cells from cord blood has been proposed as a novel therapy for T1DM, with the advantages of no risk to the donors, minimal ethical concerns, a low incidence of graft-versus-host disease and easy accessibility. In this review, we revisit the role of autologous umbilical cord blood or immune cells from cord blood-based applications for the treatment of T1DM.

  5. Short stature with umbilical hernia - Not always due to cretinism: A report of two cases

    Directory of Open Access Journals (Sweden)

    Sharvil S Gadve

    2012-01-01

    Full Text Available A 7-year-old boy presented with umbilical hernia and short stature. Growth retardation, recurrent upper respiratory tract infections and delayed developmental milestones were present from infancy. Umbilical hernia was diagnosed at the age of 5 years. On examination, he had short-trunk dwarfism, large head circumference, coarse facial features, joint stiffness, hepatosplenomegaly, and mild mental retardation. He had normal biochemical parameters, thyroid function tests and arterial blood gas analysis. Radiological evaluation showed that the child had Hunter syndrome with findings of J-shaped sellaturcica, proximal bulleting of metacarpals, spatulated ribs and anterior beaking of lumbar vertebrae. The second case was a 6-year-old girl with umbilical hernia, short stature, normal biochemistry and radiological findings of mucopolysaccharidosis. However, she also had corneal opacity; confirmed by slit-lamp examination, which led to the diagnosis of Hurler-Scheie syndrome. Enzymatic studies could not be done in both the cases, as they are not available at most centers.

  6. Methods of isolation, expansion, differentiating induction and preservation of human umbilical cord mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    LI Dong-rui; CAI Jian-hui

    2012-01-01

    Objective This literature review aims to summarize the methods of isolation,expansion,differentiation and preservation of human umbilical cord mesenchymal stem cells (hUCMSCs),for comprehensive understanding and practical use in preclinical research and clinical trials.Data sources All the literature reviewed was published over the last 10 years and is listed in PubMed and Chinese National Knowledge Infrastructure (CNKI).Studies were retrieved using the key word "human umbilical cord mesenchymal stem cells".Results Explants culture and enzymatic digestion are two methods to isolate hUCMSCs from WJ and there are modifications to improve these methods.Culture conditions may affect the expansion and differentiating orientations of hUCMSCs.In addition,hUCMSCs can maintain their multi-potential effects after being properly frozen and thawed.Conclusion Considering their multi-potential,convenient and non-invasive accessibility,low immunogenicity and the reported therapeutic effects in several different preclinical animal models,hUCMSCs have immense scope in regeneration medicine as a substitute for MSCs derived from bone marrow or umbilical cord blood.

  7. Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews

    Directory of Open Access Journals (Sweden)

    Cunping Yin

    2016-01-01

    Full Text Available Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigated the role of umbilical cord-derived mesenchymal stem cells (UC-MSCs in regulating angiogenesis and relieving hindlimb ischemia. UC-MSCs were isolated from the umbilical cord of tree shrews. Angiography results showed that UC-MSCs injection significantly promoted angiogenesis in tree shrews. Moreover, the ankle brachial index, transcutaneous oxygen pressure, blood perfusion, and capillary/muscle fiber ratio were all markedly increased by the application of UC-MSCs. In addition, the conditioned culture of human umbilical vein endothelial cells using medium collected from UC-MSCs showed higher expression of angiogenic markers and improved migration ability. In short, the isolated UC-MSCs notably contributed to restoring blood supply and alleviating the symptoms of limb ischemia through enhancing angiogenesis.

  8. Single-site multi-port laparoscopic endo-surgery: the simple technique - a useful method of purely umbilical porting that ensures triangular laparoscopic ergonomics

    International Nuclear Information System (INIS)

    Umbilical single-port surgery is a recent development that produces better cosmesis and lesser pain. However, the steep learning curve and the higher surgical expense have led to its rather sceptical acceptance. In this regard, a technique is hereby described in which three ports are directly inserted on the umbilical mound (without raising the umbilical-flap) through three small incisions to form an isosceles triangle. The respective fascial-entries are made farther away to achieve satisfactory inter trocar distance. This technique complies with the laparoscopic triangulation principles, likely to further reduce postoperative umbilical pain/morbidity, and achieve good umbilical aesthetics as the scars recede within the umbilicus. As only the routine laparoscopic instruments were utilized, it also has a potential to reduce the surgical cost. Therefore, the authors feel that this technique can be a valuable addition to the existing umbilical laparoscopic methods. (author)

  9. Gravid med spontan ruptur af arteria uterina

    DEFF Research Database (Denmark)

    Jònsdòttir, Fjòla; Pinborg, Anja; Wilken-Jensen, Charlotte

    2014-01-01

    Pregnant women with acute abdominal pain are a clinical challenge. We present a rare but potential life-threatening condition of a pregnant woman with acute abdominal pain. The woman was in gestational week 37 with severe abdominal pain and was admitted to the labour ward. She became haemo......-dynamic instable 24 hours after vaginal delivery, and emergency laparotomi revealed a spontaneous rupture of the right uterine artery. Spontaneous rupture of the uterine artery is rare but should be considered as a possible cause of acute abdominal pain in pregnant women....

  10. Promoção de Saúde e a Funcionalidade Humana

    Directory of Open Access Journals (Sweden)

    Ana Cristhina de Oliveira Brasil

    2013-03-01

    meio de qualificadores que a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF tem possibilidade de gerar(2.O Brasil é um país-membro da Organização Mundial de Saúde, signatário da Resolução WHA54.21-OMS54.21, que recomenda o uso da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF, traduzida para o português em 2003. O principal paradigma que a CIF traz é a mudança de um olhar centrado na doença para um olhar centrado na funcionalidade humana(3. Somente em maio de 2012 o Conselho Nacional de Saúde aprovou a resolução 452 para que o Ministério da Saúde faça uso da CIF, entre outros usos, como geradora de indicadores da funcionalidade humana(4. Funcionalidade humana, de acordo com a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF da Organização Mundial de Saúde, é um termo macro que designa os elementos do corpo, sua funções e estruturas, as atividades humanas e a participação do ser humano nos processos sociais, indicando os aspectos positivos da interação dos indivíduos com determinada condição de saúde e o contexto em que ele vive no que diz respeito aos fatores pessoais e ambientais (estruturais e atitudinais(3.Contudo, a informação em saúde se apresenta incompleta, uma vez que os dados acerca da funcionalidade humana ainda são insignificantes para que as politicas desenvolvidas de modo intersetorial possam apresentar os resultados esperados frente às incapacidades representadas pelas deficiências, limitações nas atividades e restrições da participação(5.Diante do exposto, é necessária uma mudança de direção nos caminhos das politicas públicas de saúde no Brasil, deixando de ver a doença apenas como aspecto biológico, e sim como problema de saúde produzido pela sociedade. Portanto, é preciso desenvolver informações que registrem não só a doença, mas também os demais aspectos da situação de saúde dos indiv

  11. Robot con figura humana para la realización de tareas de mercadeo y publicidad

    Directory of Open Access Journals (Sweden)

    Gustavo Ruiz Duarte

    2009-07-01

    Full Text Available Resumen:En el presente trabajo se describe una propuesta destinada a desarrollar un sistema robotizado con figura humana,especie de humanoide, capacitado para realizar diferentes tareas. Inicialmente, se preparara para la realizaciónde la tarea específica de mercadeo y publicidad en diferentes sectores de la población y para una variadagama de productos y servicios. Dentro del desarrollo del mismo se asegura el estudio científico de las diferentesfases de la robótica y las telecomunicaciones y sus interrelaciones con la ingeniería de sistemas, no solo comoun complemento de este programa, sino además como un énfasis de la misma. Se definen las posibles etapas ymétodos que se van a emplear en su desarrollo y las múltiples aplicaciones tecnológicas del trabajo.Palabras claves:Interrelaciones, microcontroles, tiempo real, Robótica, dispositivoAbstract:This job describes a proposal to develop a robotic system with a human image, like a humanoid, able to performdifferent tasks. First at all, be prepared to perform the specific task of marketing and advertising and for a widerange of products and services. Within the development, it ensures the scientific study of the different phases ofrobotics and telecommunications and their relationships with systems engineering, not only as a supplement to thisdiscipline also as a focus of it. Possible stages are defined and methods to be used in its development and the manytechnological applications of the job.Key Words:Interrelations, microcontrollers, real-time, robotic, device.

  12. Componentes prenatal y postnatal de la diferenciación craneofacial entre dos poblaciones humanas

    Directory of Open Access Journals (Sweden)

    Sardi, Marina Laura

    2007-01-01

    Full Text Available Parte importante de la diferenciación craneofacial interpoblacional ya está presente en etapas tempranas de la ontogenia postnatal. Sin embargo, se desconoce qué parte de la diferenciación se produce en la etapa prenatal. El objetivo de este estudio es evaluar la diferenciación craneofacial entre dos poblaciones humanas en dos etapas ontogénicas: menores de 1 año de edad y adultos, a fin de determinar que parte de la diferenciación se produce en la etapa prenatal y en la postnatal. Se estudiaron cráneos adultos y menores a 1 año de edad, de origen europeo (EUR y de poblaciones nativas sudafricanas (SAF. Se registraron 32 landmarks. Las coordenadas tridimensionales se analizaron mediante Análisis Generalizado de Procrustes (AGP y con las coordenadas obtenidas, se realizó Análisis de Componentes Principales (ACP. El análisis discriminante hecho con los escores AGP/ACP indicó que hay diferenciación entre EUR y SAF en adultos (Wilks=0.12** y en sub-adultos (Wilks= 0.07**. Según las grillas de deformación, los adultos SAF presentan cráneos mas largos en sentido anteroposterior y prognatismo facial y landmarks laterales del neurocráneo ubicados mas superiormente respecto de EUR; en los sub-adultos se observa diferenciación similar en el neurocráneo, pero poca diferenciación en la cara. Esto indica que la diferenciación en la forma neurocraneana se produce en la ontogenia prenatal y se acentúa posteriormente. La diferenciación facial, en cambio, se produce principalmente durante la ontogenia postnatal.

  13. Flujo y concentración de proteínas en saliva total humana

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    BANDERAS-TARABAY JOSÉ ANTONIO

    1997-01-01

    Full Text Available Objetivo. Determinar los promedios de flujo salival y la concentración de proteínas totales en una población joven del Estado de México. Material y métodos. Se seleccionaron 120 sujetos a quienes se les colectó saliva total humana (STH no estimulada y estimulada, la cual se analizó por medio de gravimetría y espectrofotometría (LV/LU; se calcularon medidas de tendencia central y de dispersión; posteriormente, se correlacionaron estos datos con los índices CPOD y CPITN. Resultados. Los sujetos estudiados mostraron un promedio de flujo salival (ml/min ± DE en STH no estimulada de 0.397±.26, y en STH estimulada, de 0.973±.53. El promedio en la concentración de proteínas (mg/ml ± DE fue de 1.374±.45 en STH no estimulada y de 1.526±.44 en STH estimulada. Las mujeres presentaron un menor porcentaje de flujo salival y mayor concentración de proteínas. No se observaron correlaciones entre el flujo y la concentración de proteínas totales y el CPOD y CPITN; sin embargo, sí las hubo con otras variables. Conclusiones. Estos hallazgos podrían estar asociados con el grado de nutrición, las características genéticas y los niveles de salud bucal en nuestra población. El presente estudio representa la fase inicial de la creación de una base de datos en sialoquímica, cuya meta será identificar los parámetros que indiquen el riesgo de enfermedades sistémicas o bucodentales.

  14. Efeitos do consumo de aditivos químicos alimentares na saúde humana

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    Franciéli Aline Conte

    2016-06-01

    Full Text Available A industrialização de alimentos revolucionou a alimentação influenciada pelo grande crescimento populacional e pela grande urbanização apresentando vantagens em relação à durabilidade, praticidade e preço, mas também desvantagens quando relacionados à saúde. O objetivo deste trabalho é mostrar os efeitos que os aditivos alimentares provocam sobre a saúde humana. Este trabalho é uma revisão bibliográfica de literaturas nacionais e internacionais, em trabalhos de revisão, experimental e em seres humanos tendo como base de dados: Capes, Scielo, MedLine, PubMed, Google Acadêmico, Bireme, além de sites e livros da área de nutrição. Antioxidantes, corantes, conservantes, emulsificantes e outros aditivos alimentares, a medida que permitem maior durabilidade, cor, sabor, maciez, crocância e outras características aos produtos, por outro lado, provocam alergias diversas, principalmente para crianças, são potencialmente cancerígenos; precursores de mal de Parkinson; mal de Alzheimer; além de serem resistentes insulínicos, e hipertensivos. O consumo de alimentos processados/industrializados possui efeitos negativos sobre a saúde, principalmente relacionados à doenças crônicas não transmissíveis como a hipertensão, diabetes mellitus tipo II, cânceres e doenças desmielinizantes.

  15. Justicia global y seguridad humana en el contexto del cambio climático

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    Moreno Muñoz, Miguel

    2010-12-01

    Full Text Available The concept of global justice has inspired diverse reactions to market globalism. Although many of its challenges are still in force, they have acquired new meanings in the context of the economic, social and humanitarian crisis induced by the extreme phenomena associated with climate change. The constructs of democracy and justice, usually theorized in national contexts, may fail to function properly when applied to transnational contexts of problems, which can compromise the safety of individuals and communities (like those associated with climate change. A new frame, centred on the notion of human safety, is needed to consider crucial aspects in the relation between environmental crisis, unsustainable development and risk of authoritarian bias or violent conflict, with substantive implications for the concept of global justice and the democratic mechanisms of international governance.

    El concepto de justicia global ha permitido articular formas diversas de reacción al globalismo del mercado. Aunque muchos de sus desafíos siguen vigentes, han adquirido nuevos significados en el contexto de la crisis económica, social y humanitaria inducida por los fenómenos extremos asociados al cambio climático. Los conceptos de democracia y justicia, teorizados habitualmente en contextos nacionales, pueden ocasionar ciertas disfunciones cuando se aplican a contextos de problemas trans-nacionales que pueden comprometer la seguridad de individuos y comunidades, como son los asociados al cambio climático. Un enfoque centrado en la noción de seguridad humana obliga a considerar aspectos cruciales de la relación entre crisis ambiental, desarrollo no sostenible y riesgo de deriva autoritarista o conflicto violento, con implicaciones sustantivas para el concepto de justicia global y los mecanismos democráticos de gobernanza internacional.

  16. Estandarizacion y evaluacion de un enzimoinmunoensayo para diagnostico y seroepidemiologia de triquinosis humana

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    Emílio Coltorti

    1987-12-01

    Full Text Available Se estandarizó un enzimoinmunoensayo (EIE en fase sólida en el que se empleó un antígeno soluble total de T. spiralis y una dilución única de suero, y se evaluó la capacidad del sistema para detectar anticuerpos totales antitriquina con fines diagnósticos y seroepidemiológicos. Las curvas dosis respuesta mostraron que trabajando con una dilución de suero de 1:100 se obtenía una buena diferenciación entre sueros de indivíduos no infectados y pacientes de triquinosis con baja concentración de anticuerpos circulantes y la respuesta fue lineal entre valores de 0.15 y 0.64 unidades de densidad óptica (DO. El estúdio de 720 sueros de población general no infectada revelo una X k = 0.07 y una S = 0.03 unidades de DO. El 98,61% de esta población presentó valores de DO X k + 3S y X k + 4S y < X k + 5S. Se empleó un valor de DO = X k + 5S como nivel diagnóstico para estudiar 4 brotes de triquinosis humana, 80 sueros de pacientes de triquinosis con diferentes títulos en inmunofluorescencia indirecta (IFI y 20 sueros de pacientes de hidatidosis. El EIE propuesto permitió diferenciar en forma confiable y eficiente población infectada de no infectada y tuvo una buena correlación con la IFI. Todos los sueros de pacientes hidatídicos presentaron valores de DO < X k + 4S.

  17. Salir de la violencia. Una obra pendiente para las ciencias humanas y sociales

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    Michel Wieviorka

    2016-01-01

    Full Text Available El análisis de la violencia es un amplio campo de las ciencias humanas y sociales en el que se distinguen, e incluso se oponen, casi todos sus paradigmas. Junto con el de la religión -que de hecho no le es necesariamente extraño-, constituye un registro central, una de las principales preocupaciones de la investigación en estas áreas. El salir de la violencia es mucho menos estudiado que la violencia en sí misma. Constituye una preocupación política, jurídica y ética, casi siempre práctica y concreta, incluso aplicada. Analizar el salir de la violencia exige trabajar simultáneamente en varios registros. En este caso, nos abocaremos a analizar el salir de la violencia social o política -incluso geopolítica- cuando ésta ha sido en extremo mortífera, manifestada sobre todo en la forma de genocidios, masacres en masa, guerra civil o terrorismo. Dejaremos de lado el tema de la violencia simbólica, la violencia criminal o delincuencial -aunque frecuentemente todo esté imbricado o parezca indiferenciable- en tanto que ésta usualmente se ve favorecida en el contexto de guerra civil, de guerrilla o de terror, de modo que en muchas experiencias contemporáneas se ha vuelto imposible separar el crimen organizado de la violencia política.

  18. La clonación humana y el problema de la identidad

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    Calise, Santiago Gabriel

    2015-12-01

    Full Text Available The following paper deals with the problems that human cloning entails for identity, owing to the fact that this concept has been erected as one of the main arguments to try to found a ban on the aforementioned technique. Notwithstanding this, identity appears not only among the ethical arguments, but also in the definitions of cloning and the metaphors used to qualify the human beings born in that way. In all these levels different interpretations of the idea of identity are intermingled, many times creating confusions on the level where this reasoning unfolds. Through philosophical developments of this concept, as those provided by Ricoeur, it is expected to assess to which extent the identity of the human being born through cloning would be offended by the technique.El siguiente trabajo se propone indagar los problemas que la clonación humana acarrearía para la identidad, debido a que este concepto se ha erigido en uno de los principales argumentos para intentar fundamentar una prohibición de la mencionada práctica. Sin embargo, la categoría de identidad aparece no solamente en los argumentos éticos, sino también en las definiciones de la clonación y en las metáforas utilizadas para calificar a los seres nacidos por esta vía. En todos esos planos, se entremezclan diferentes interpretaciones de la idea de identidad, muchas veces creándose confusiones sobre el plano donde se despliegan estos razonamientos. A través de desarrollos filosóficos del concepto, como los aportes de Ricoeur, se pretende evaluar hasta qué punto la identidad del ser nacido por clonación se vería ultrajada por la técnica mencionada.

  19. Autopoiesis, bucles, emergencia, variedades topológicas y una conjetura sobre la consciencia humana

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    Sarmiento Campos, José A.

    2009-08-01

    Full Text Available This reflection aims to be a plausible approach to the concept of consciousness and it proposes a theory to explain its emergency. This theoretical approach integrates some of the contributions that different authors have made to science. Some of these contributions are examples of complexity in themselves (such as the concept of system, autopoiesis, emergency, cybernetic; some others are in the scope of mathematics (the concept of n-dimensional topological manifold and even some of them are related to biology (neural networks, cortical layers or columnar organization of the neocortex. All of them can be integrated in a theory, which we consider epistemologically solid and could provide an answer to questions such as the emergency of human and social consciousness.La presente reflexión pretende ser un acercamiento plausible al concepto de consciencia y propone una explicación a su surgimiento. Varias de las aportaciones que diversos autores han hecho a la ciencia y que conforman el paradigma de la complejidad, como son los conceptos de sistema, autopoiesis, emergencia, cibernética de primer y segundo orden o estado crítico; junto con otros de naturaleza matemática como las variedades topológicas n-dimensionales y aun otros procedentes de la biología como redes neuronales, capas corticales o distribución columnar de la neocorteza, se pueden integrar en un constructo, que consideramos epistemológicamente sólido, que podría dar una respuesta a cuestiones como la emergencia de la consciencia humana y también, probablemente, social.

  20. Comparison between mechanical properties of human saphenous vein and umbilical vein

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    Hamedani Borhan

    2012-08-01

    Full Text Available Abstract Background As a main cause of mortality in developed countries, Coronary Artery Disease (CAD is known as silent killer with a considerable cost to be dedicated for its treatment. Coronary Artery Bypass Graft (CABG is a common remedy for CAD for which different blood vessels are used as a detour. There is a lack of knowledge about mechanical properties of human blood vessels used for CABG, and while these properties have a great impact on long-term patency of a CABG. Thus, studying these properties, especially those of human umbilical veins which have not been considered yet, looks utterly necessary. Methods Umbilical vein, as well as human Saphenous vein, are respectively obtained after cesarean and CABG. First, histological tests were performed to investigate different fiber contents of the samples. Having prepared samples carefully, force-displacement results of samples were rendered to real stress–strain measurements and then a fourth-order polynomial was used to prove the non-linear behavior of these two vessels. Results Results were analyzed in two directions, i.e. circumferentially and longitudinally, which then were compared with each other. The comparison between stiffness and elasticity of these veins showed that Saphenous vein’s stiffness is much higher than that of umbilical vein and also, it is less stretchable. Furthermore, for both vessels, longitudinal stiffness was higher than that of circumferential and in stark contrast, stretch ratio in circumferential direction came much higher than longitudinal orientation. Conclusion Blood pressure is very high in the region of aorta, so there should be a stiff blood vessel in this area and previous investigations showed that stiffer vessels would have a better influence on the flow of bypass. To this end, the current study has made an attempt to compare these two blood vessels’ stiffness, finding that Saphenous vein is stiffer than umbilical vein which is somehow as stiff as

  1. Superparamagnetic iron oxide nanoparticles label human bone marrow and umbilical cord mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    Ma Yan; Zhang De-qing; Chen Le; Wang Jian; Zhang Xue; Hou Yan; Bi Xiao-juan; Yang Rong; Hu An-hua

    2012-01-01

      BACKGROUND: Nowadays, it is becoming more and more important to optimize safety of human derived cel s, label cel s efficiently and track cel s after cel s transplantation both in basic research and clinic application. OBJECTIVE: To compare the cel viability, labeling efficiency and imaging effect of the T2* weight image (WI) magnetic resonance (MR) between the human bone marrow and umbilical cord derived mesenchymal stem cel s labeled with the superparamaganetic iron oxide nanoparticles, as wel as to optimize their treatment efficiency. METHODS: The third generation of human bone marrow and umbilical cord derived mesenchymal stem cel s were cultured, and labeled with 5-30 mg/L Feridex Ⅳ and protamine sulfate. RESULTS AND CONCLUSION: The viability of human bone marrow mesenchymal stromal cel s was similar with human umbilical cord derived mesenchymal stem cel s (P >0.05). There was no significant difference of labeling rate between the bone marrow msenchymal stem cel s labeled with 5-30 mg/L Feridex Ⅳ(P >0.05); while there was significant difference of labeling rate between the umbilical cord derived mesenchymal stem cel s labeled with 5 mg/L Feridex Ⅳ and 20 and 30 mg/L Feridex Ⅳ(P <0.05); the positive labeling rate of umbilical cord derived mesenchymal stem cel s was lower than that of bone marrow msenchymal stem cel s after labeled with 10 mg/L FeridexⅣ(P <0.05). When two sources of cel s were labeled with Feridex Ⅳ more than 2 mg/L, the iron oxide particles were found in the cel suspension and could not be removed by elution and filtration. The signal intensity from 3.0T MR GRE T2*WI scan was decreased with the increasing of Feridex Ⅳ concentration in both cel types. It is safe and effective to label the two tissue-derived mesenchymal stem cel s with 10 mg/L Feridex Ⅳ-protamine sulfate complex, and can be observed with T2*WI MR.

  2. Human umbilical cord Wharton's Jelly-derived mesenchymal stem cells differentiation into nerve-like cells

    Institute of Scientific and Technical Information of China (English)

    MA Lian; FENG Xue-yong; CUI Bing-lin; Frieda Law; JIANG Xue-wu; YANG Li-ye; XIE Qing-dong; HUANG Tian-hua

    2005-01-01

    Background The two most basic properties of mesenchymal stem cells (MSCs) are the capacities to self-renew indefinitely and differentiate into multiple cells and tissue types. The cells from human umbilical cord Wharton's Jelly have properties of MSCs and represent a rich source of primitive cells. This study was conducted to explore the possibility of inducing human umbilical cord Wharton's Jelly-derived MSCs to differentiate into nerve-like cells.Methods MSCs were cultured from the Wharton's Jelly taken from human umbilical cord of babies delivered after full-term normal labor. Salvia miltiorrhiza and β-mercaptoethanol were used to induce the human umbilical cord-derived MSCs to differentiate. The expression of neural protein markers was shown by immunocytochemistry. The induction process was monitored by phase contrast microscopy, electron microscopy (EM), and laser scanning confocal microscopy (LSCM) .The pleiotrophin and nestin genes were measured by reverse transcription-polymerase chain reaction (RT-PCR). Results MSCs in the Wharton's Jelly were easily attainable and could be maintained and expanded in culture. They were positive for markers of MSCs, but negative for markers of hematopoietic cells and graft-versus-host disease (GVHD)-related cells. Treatment with Salvia miltiorrhiza caused Wharton's Jelly cells to undergo profound morphological changes. The induced MSCs developed rounded cell bodies with multiple neurite-like extensions. Eventually they developed processes that formed networks reminiscent of primary cultures of neurons. Salvia miltiorrhiza and β-mercaptoethanol also induced MSCs to express nestin, β-tubulinⅢ, neurofilament (NF) and glial fibrillary acidic protein (GFAP). It was confirmed by RT-PCR that MSCs could express pleiotrophin both before and after induction by Salvia miltiorrhiza. The expression was markedly enhanced after induction and the nestin gene was also expressed.Conclusions MSCs could be isolated from human umbilical

  3. CORRELATION OF UMBILICAL CORD LENGTH WITH FOETAL A ND MATERNAL OUTCOME

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    Yadav

    2013-01-01

    Full Text Available ABSTRACT: INTRODUCTION: The cord disposition and length of umbilical cord in the amniotic cavity remain unrecognised till the birth of the ba by.Cord complications remain one of the major causes of foetal death. OBJECTIVES: To study 1. Length of umbilical cord in new-born babies 2. The outcome of pregnancy with abnormal length of umb ilical cord 3. The relation between umbilical cord length and cord abnormalities 4. Relation between umbilical cord abnormalities and pe rinatal outcome METHODS: This study of 200 cases was carried out in S.R.T.R. Medical College, Ambajogai over a period of 6 months from Jan 2011 to Jun 2011. 100 cases belonged to control group (cord length 50-60 cm. Study group had short cord (i.e. c ord length less than 50 cm comprising 20 cases and long cord (i.e. cord length above 60 cm comprising 80 cases. Apgar score at 1 and 5 minutes after birth were recorded. Birth weight and sex of all babies were noted. Number of loops of cord and position noted. Cord loop tight or l oose noted (only for LSCS cases. RESULTS: Maximum numbers of cases were from age group 20-24 years. Parity was not found to affect cord length. Maximum cases (31.25% of fo etal distress were found in group with cord length more than 60 cm. Significantly low APGAR sco re at 5 mins noted in long cord group (15% than control group. Cord length in control and study group in relation to the sex of the foetus was found to be statistically insignificant. 30 cases from long cord group required caesarean section and most of them for foetal distr ess. Cord entanglement (88.75% was the most common complication in long cord group. CONCLUSION: Minimum observed cord length in this study was 28 c m and maximum cord length was 98 cm. There was no relation between mat ernal age, parity, sex of the foetus with the umbilical cord length. Cord abnormalities were obse rved in long cord group only. Higher percentage of caesarean section and perinatal mortali ty was more in long

  4. Umbilical melanoma: case report and review of anatomical and therapeutic aspects

    International Nuclear Information System (INIS)

    Full text of publication follows: Background: Malignant melanoma corresponds to 5% of cutaneous neoplasias. However, umbilical melanoma is a rare occurrence, with only 13 cases reported on the literature. The purpose of this article is to present a case of umbilical primary melanoma, discuss the anatomy and lymphatic drainage of this region, and the therapeutic aspects. Clinical description: Three years ago, a 65 years-old white woman from Recife-PE, presented an umbilical pigmented nevus. It grew in size and one year ago the pigmentation increased. Examination showed depressed umbilical scarring completely filled by pigmented lesion with 1.5 cm, irregular borders and a depigmented area; no enlarged inguinal and axillary lymph nodes. Chest X-Ray, CT scan of abdomen and pelvis, and ultrasonography of groin and axillary lymphatic chains were normal. The pathological diagnosis after incisional biopsy was ulcerated malignant melanoma, without defining Breslow classification. Subsequently a complete excision of the lesion was performed; slide showed Breslow 8 mm and 1 mm of margin. Lymphoscintillography showed three left axillary lymph nodes. During surgical widening, the peritoneum seemed disease-free. Lymphatic mapping identified three lymph nodes, one of them not coloured by vital blue. All the lymph nodes were free of metastasis on histopathological and immunohistochemical examination. Discussion: Among the umbilical tumors, 80% are metastatic, the most common branch of which is the gastrointestinal tract. Melanoma is included in the other 20% corresponding to primary neoplasias of the umbilicus, which also include sarcomas, basal cell carcinomas and squamous cell carcinomas. From the embryological point of view, the umbilical scar can contain residues of several types of epithelial tissue of the gastrointestinal duct remaining from the omphalomesenteric duct. Anatomical aspects remain to be studied, such as the cylindrical form and the content within its thickness

  5. Effect of selective occlusion of the umbilical arteries and/or veins on uterine blood flow in sheep.

    Science.gov (United States)

    Hasaart, T H; de Haan, J; Horiguchi, T

    1986-01-01

    Maternal uterine blood flow was depressed during total umbilical cord occlusion, probably based on an increased fetal cotyledonary tissue pressure (Hasaart and de Haan (1985) Eur. J. Obstet. Gynec. Reprod. Biol., 19, 125-131). This supposed mechanism was further analysed by performing selective occlusions of the umbilical arteries and/or veins (mean occlusion time 35 s). An occluding device which allowed separate occlusion of umbilical veins and arteries was applied to the umbilical cord in 7 chronically prepared fetal lambs between 106 and 135 days gestation. Median uterine artery blood flow (UBF) was measured with an electromagnetic flow meter. During occlusion of both umbilical veins (VV, n = 22) in 6 animals a maximal decrease in UBF to 87.5% of control value (P less than 0.001) was found at the end occlusion, followed by a gradual return to control value in the post occlusion period. Occlusion of both umbilical arteries (AA, n = 29) in 5 animals was accompanied by a slight increase in UBF to 103% of control value (P less than 0.01). Total occlusion of the umbilical arteries and veins simultaneously (n = 17) in 4 animals did not result in any change in UBF. The changes in volume and turgor in the fetal cotyledonary tissue associated with the arterial and venous occlusions should lead to respectively a decrease (AA) and increase (VV) in resistance to maternal flow, causing the changes in uterine blood flow. It is concluded that volume changes in the fetal compartment of the sheep placenta affect maternal uterine blood flow. PMID:3956829

  6. Tratamiento contra la rabia humana: un poco de su historia Tratamento contra a raiva humana: um pouco de sua histária A historical review of the treatment of human rabies

    OpenAIRE

    Maria Cristina Schneider; Carlos Santos-Burgoa

    1994-01-01

    El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de vene...

  7. Acción humana y "disposición de ánimo" desde la perspectiva fenomenológica (Alexander Pfänder, Dietrich von Hildebrand y Max Scheler)

    OpenAIRE

    Sánchez-León, A. (Alberto); Sánchez-Migallón, S. (Sergio)

    2009-01-01

    La tesis lleva por título "Acción humana y disposición de ánimo desde la perspectiva fenomenológica (Alexander Pfänder, Dietrich von Hildebrand y Max Scheler)". Básicamente son estas dos nociones (la acción humana y la disposición de ánimo) las que han dividido el trabajo en dos partes. La primera sobre la acción humana y su libertad; la segunda sobre la disposición de ánimo como el fundamento subjetivo de la acción humana.

  8. EFEITO DO CONSUMO DA RAÇÃO HUMANA SOBRE O PERFIL LIPÍDICO E GLICEMIA DE RATOS

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    Janine Louise Borré

    2014-08-01

    Full Text Available 10.12957/cadest.2012.15774A Ração Humana é considerada um complemento alimentar e uma das novas tendências de dietas da moda. Este estudo avaliou os efeitos da "Ração Humana" sobre o perfil lipídico e glicemia de ratos. Foram utilizados 32 Rattus Wistar, com 45 dias de vida. Os resultados são apresentados como média aritmética e desvio padrão. Para comparação de médias foi utilizado ANOVA one-way, com Tukey como pós-teste. Foi aceito nível de significância de 5%. A glicemia manteve-se semelhante entre os grupos estudados (C: 87,9±10,4; C+RH: 90,8±7,2; H: 86,0±7,4; H+RH: 98,5±11,9. Não foi observada alteração no perfil lipídico ao longo do estudo, entre os grupos (colesterol C: 63,9 ± 13,9; C+RH: 40,4 ± 9,3; H: 55,4 ± 11,2; H+RH: 57,1 ± 7,1 (Triglicerídeos: C: 89,0 ± 32,4; C+RH: 84,6 ± 20,5; H: 57,3 ± 11,5; H+RH: 48,0 ± 5,8. Conclui-se que o consumo da ração humana não é capaz de promover diminuição na glicemia e na concentração de colesterol e triglicerídeo séricos.

  9. Continuidad de las innovaciones tecnológicas: el reto de las intervenciones biomédicas de mejora humana

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    López Frías, Francisco Javier

    2013-06-01

    Full Text Available One of the most recent debates among ethicists concerning the course of technological innovation is the human enhancement debate, which has been generated by the possibility of pushing human limits further by using the power of science. Many philosophers have warned us about the dangers of modifying human nature in a technical way. However, others argue that there are no morally salient differences between enhancing technical interventions and other kinds of technologies that human beings have taken to be usual for them. This paper shall critically analyze this argument. The main aim of this critical analysis is twofold, first, to show that people who make this argument are biased in several ways and, second, to claim that a more accurate and restricted definition of human enhancement technologies is needed.Uno de los debates más recientes referentes a la innovación tecnológica entre los especialistas en ética es aquel sobre la mejora humana, el cual ha surgido a raíz de la posibilidad de modificar los límites de la naturaleza humana usando el poder de la ciencia. Muchos filósofos nos han avisado del peligro de modificar técnicamente nuestra naturaleza humana. Otros, por contra, defienden que no existe diferencia moral relevante alguna entre las nuevas técnicas biomédicas de mejora y las tecnologías aceptadas como habituales por los seres humanos. Este artículo pretende examinar críticamente tal argumento. El fin de este análisis crítico será doble, primero, mostrar que los autores que defienden esta posición poseen visiones sesgadas y prejuiciosas de la realidad y, segundo, que es necesario establecer una definición más precisa y acotada del término “mejora”.

  10. Neutropenia crónica e infección por el virus de la inmunodeficiencia humana

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    Ronald A Noguera-Valverde

    2008-09-01

    Full Text Available Se presenta el caso de un paciente masculino con neutropenia crónica e infección por el virus de inmunodeficiencia humana, con una revisión de los posibles mecanismos patogénicos. Las alteraciones hematológicas como anemia, trombocitopenia y leucopenia se presentan asociadas con frecuencia a la infección aguda por el virus de inmunodeficiencia humana. Al establecer la terapia antirretroviral y disminuir la actividad del virus, estas alteraciones tienden a mejorar. Sin embargo, algunos fármacos antirretrovirales, como la zidovudina, poseen toxicidad medular y pueden producir o empeorar las alteraciones hematológicas en estos pacientes, lo cual lleva a cambios en los esquemas de tratamiento. Los citotóxicos y antimetabolitos empleados en el tratamiento de neoplasias asociadas tienen conocida actividad depresora sobre la médula ósea. Algunos antimicrobianos utilizados en la profilaxis de infecciones poseen también toxicidad hematológica conocida, como el trimetoprim-sulfametoxazol, por lo que deben ser utilizados con precaución en pacientes con infección por el virus de inmunodeficiencia humana. Por otro lado, se plantean mecanismos alternativos que causan neutropenia en estos pacientes, como la formación de anticuerpos antineutrófilos, daño primario del progenitor granulocítico, por desbalance en la producción de neutrófilos, por anticuerpos contra la glicoproteína gp120 de la cápside viral del VIH, y deficiencias vitamínicas. En el caso del paciente neutropénico febril, en quien se sospecha infección bacteriana grave, se pueden utilizar los factores estimulantes de las colonias de granulocitos para aumentar los conteos absolutos de neutrófilos y mejorar la recuperación clínica.

  11. Inmunoglobulina A secretora humana, como elemento capaz de modificar la infección por Mycobacterium tuberculosis

    OpenAIRE

    Alvarez Cabrera, Nadine

    2012-01-01

    La inmunoglobulina A secretora es el anticuerpo más abundante en las secreciones mucosales, sin embargo, no ha sido evaluado el papel de esta inmunoglobulina obtenida de calostro humano en la protección contra patógenos micobacterianos. En este trabajo, nos propusimos como objetivo principal obtener la inmunoglobulina secretora humana (IgAsh) de calostro y evaluar su potencial protector frente a la infección con Mycobacterium tuberculosis en ratones. Se obtuvo IgAsh mediante una combinació...

  12. Responsabilidad social y gestión del conocimiento como estrategias de gestión humana

    OpenAIRE

    Juan Guillermo Saldarriaga Ríos

    2013-01-01

    Este artículo aborda la responsabilidad social y la gestión del conocimiento como estrategias de gestión humana, conexas e inseparables, en las organizaciones. Estas estrategias hacen posible que la organización mire hacia sí misma y reconozca los impactos que estas prácticas tienen sobre sus miembros, asumiéndolas no solo exclusivamente como actividades que le genera ganancias económicas y visibilidad en el escenario social, sino como parte integral de su forma de concebir y admini...

  13. Controle microbiológico em valvas cardíacas humanas Microbiologyc control in human heart valves

    OpenAIRE

    Angela Maria Peruzzo; Francisco Diniz Affonso da Costa; Wanda Moscalewski Abrahão

    2006-01-01

    OBJETIVO: Avaliar, sob o aspecto microbiológico, valvas processadas pelo Banco de Valvas Cardíacas Humanas da Irmandade da Santa Casa de Misericórdia de Curitiba, para serem utilizadas em cirurgias cardiovasculares. MÉTODOS: Foi avaliado o processamento de 1.671 valvas, no período de junho de 1999 a junho de 2004. Das valvas e soluções envolvidas no processo foram coletadas amostras e semeadas nos meios de cultura: meio líquido tioglicolato, caldo soja tripticaseína e caldo Sabouraud, com qua...

  14. Aproximación al análisis jurídico de la clonación humana

    OpenAIRE

    Cortés Preciado, Erika Soraya

    2015-01-01

    A partir del examen de la información obtenida dentro del proceso investigativo, se plantea el análisis general de los conceptos y principios tanto científicos como jurídicos relativos a la clonación humana; previo abordaje y desarrollo de todos los temas trasversales influyentes en el análisis y decisión de admisibilidad, restricción o prohibición de la manipulación genética encausada a la obtención de productos clónicos o cualquiera de las subespecialidades en la biogenética.

  15. Pérdidas Humanas y Económicas Causadas por el Vulcanismo en Costa Rica entre 1953 y 2005

    OpenAIRE

    Irene Aguilar; Guillermo E. Alvarado

    2014-01-01

    Se presenta por primera vez una aproximación integrada de los efectos de las erupciones volcánicas en el periodo comprendido entre los años 1953 y el 2005. El detalle de los daños en (puentes, casas, ferrocarril, fábricas), las pérdidas económicas (agricultura, ganadería, suministro de agua potable), interrupción de las actividades, pérdidas de vidas humanas y las inversiones (donaciones, medidas paliativas), se presenta en los correspondientes cuadros, los que se centran en los desastres y e...

  16. Clonación humana y otros conflictos éticos en La isla/ The Island (2005)

    OpenAIRE

    Blanco Mercadé, Antonio

    2009-01-01

    [ES] Los avances científicos y biotecnológicos se acompañan siempre de problemas éticos, algunos de los cuales se pueden identificar en La Isla. Un desastre ecológico pone en peligro la supervivencia de la especie humana y se impide a los individuos tomar sus decisiones libre y voluntariamente, anulando su condición moral para ser utilizados como medios. El fin perseguido en la película (trasplante de órganos para salvar vidas) no justifica los medios empleados (clonación de donantes que igno...

  17. La clonación humana ante la reforma penal y administrativa en España

    OpenAIRE

    Urruela Mora, Asier

    2008-01-01

    En la esfera de las biotecnologías una de las cuestiones que ha planteado un mayor interés, tanto desde el punto de vista científico como normativo, es la atinente a la clonación humana. En su vertiente reproductiva la misma ha dado lugar en la mayor parte de los estados a la configuración de ilícitos de naturaleza penal avalados por los textos internacionales. Por el contrario, la clonación terapéutica ha abierto nuevas expectativas en relación con patologías actualmente muy grav...

  18. Los giros de la geografía humana y la búsqueda del sujeto perdido

    OpenAIRE

    Lindón, Alicia

    2014-01-01

    Uno de los horizontes más relevantes de la geografía humana actual se ubica en la encrucijada de los múltiples “giros” que han ido envolviendo crecientemente a la disciplina —giros cultural, humanista, geográfico, relativista—. Cada uno de estos giros, así como la conjunción de todos o varios de ellos, ha conducido a una reflexión profunda sobre el concepto de espacio, y de manera más amplia, ha inducido una revisión de las concepciones acerca de la espacialidad. Como una derivación de esto, ...

  19. Ley y sociabilidad en Giambatista Vico : hacia una historia crítica de las ciencias humanas

    OpenAIRE

    Pagden, Anthony

    1997-01-01

    Este ensayo mantiene que el principal objetivo de la ciencia nueva de Giambattista Vico fue establecer una teoría de la sociabilidad humana. El proyecto de Vico consistió en hallar una alternativa al principio defendido por los teóricos del derecho natural del siglo XVII (Grocio, Pufendorf y Selden), según el cual la sociedad era el resultado de un contrato que habrían concluido los hombres primitivos con vistas a su propia protección. Esta alternativa debía también evitar el principio aristo...

  20. Fenomenología de la sociabilidad Humana fundamentos de la acción social: un ensayo

    OpenAIRE

    Pedro F. Hernández Ornelas

    2013-01-01

    El trabajo ambiciona reconocer las formas de energía material e inmaterial que constituyen la base de la acción social, fundamento y vehículo de las comunidades y sociedades humanas. Con base en los conocimientos actuales de la física cuántica se exploran, primero, los elementos fundamentales para el obrar humano y se pone en relieve la direccionalidad de la energía/materia como expresión previa de la intencionalidad voluntaria del ser humano. En segundo lugar se analizan las condiciones que ...