Measurement of the {ital D}{sup +}{sub {ital s}}{r_arrow}{eta}l{sup +}{nu} and {ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}l{sup +}{nu} branching ratios

Energy Technology Data Exchange (ETDEWEB)

Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Duboscq, J.E.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Kopp, S.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Stone, S.; Xing, X.; Bartelt, J.; Csorna, S.E.; Jain, V.; Marka, S.; Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Barish, B.; Chadha, M.; Chan, S.; Cowen, D.F.; Eigen, G.; Miller, J.S.; O`Grady, C.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F.; Asner, D.M.; Athanas, M.; Bliss, D.W.; Brower, W.S.; Masek, G.; Paar, H.P.; Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Roberts, D.; Ryd, A.; Tajima, H.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Lohner, M.; Park, H.; Rankin, P.; Smith, J.G.; Alexander, J.P.; (CLEO Collaborat...

1995-11-20

Using the CLEO II detector we measure {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{ital e}{sup +}{nu})/{ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu}) =1.24{plus_minus}0.12{plus_minus}0.15, {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu})=0.43{plus_minus}0.11{plus_minus}0.07, and {ital B}({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{prime}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}{eta}{ital e}{sup +}{nu})=0.35{plus_minus}0.09{plus_minus}0.07. We find the ratio of vector to pseudoscalar final states, {ital B}{bold (}{ital D}{sup +}{sub {ital s}}{r_arrow}{phi}{ital e}{sup +}{nu})/{ital B} ({ital D}{sup +}{sub {ital s}}{r_arrow}({eta}+{eta}{prime}){ital e}{sup +}{nu}{bold )}=0.60{plus_minus}0.06{plus_minus}0.06, which is similar to the ratio found in nonstrange {ital D} decays. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

Arrow Lakes Reservoir Fertilization Experiment, Technical Report 1999-2004.

Energy Technology Data Exchange (ETDEWEB)

Schindler, E.

2007-02-01

The Arrow Lakes food web has been influenced by several anthropogenic stressors during the past 45 years. These include the introduction of mysid shrimp (Mysis relicta) in 1968 and 1974 and the construction of large hydroelectric impoundments in 1969, 1973 and 1983. The construction of the impoundments affected the fish stocks in Upper and Lower Arrow lakes in several ways. The construction of Hugh Keenleyside Dam (1969) resulted in flooding that eliminated an estimated 30% of the available kokanee spawning habitat in Lower Arrow tributaries and at least 20% of spawning habitat in Upper Arrow tributaries. The Mica Dam (1973) contributed to water level fluctuations and blocked upstream migration of all fish species including kokanee. The Revelstoke Dam (1983) flooded 150 km of the mainstem Columbia River and 80 km of tributary streams which were used by kokanee, bull trout, rainbow trout and other species. The construction of upstream dams also resulted in nutrient retention which ultimately reduced reservoir productivity. In Arrow Lakes Reservoir (ALR), nutrients settled out in the Revelstoke and Mica reservoirs, resulting in decreased productivity, a process known as oligotrophication. Kokanee are typically the first species to respond to oligotrophication resulting from aging impoundments. To address the ultra-oligotrophic status of ALR, a bottom-up approach was taken with the addition of nutrients (nitrogen and phosphorus in the form of liquid fertilizer from 1999 to 2004). Two of the main objectives of the experiment were to replace lost nutrients as a result of upstream impoundments and restore productivity in Upper Arrow and to restore kokanee and other sport fish abundance in the reservoir. The bottom-up approach to restoring kokanee in ALR has been successful by replacing nutrients lost as a result of upstream impoundments and has successfully restored the productivity of Upper Arrow. Primary production rates increased, the phytoplankton community responded

Search for the flavor changing neutral current B-meson decays B^+arrow μ^+ μ^- K^+ and B^0arrow μ^+ μ^-K^*0 at CDF.

Science.gov (United States)

Erdmann, Wolfram; Speer, Thomas

1997-04-01

We present a search for rare B-meson decays B^+arrow μ^+ μ^- K^+ and B^0arrow μ^+ μ^-K^*0 using data from pbarp collisions at √s = 1.8 TeV recorded with CDF during the 1994 to 95 running period. We set upper limits on BR(B^+arrow μ^+ μ^- K^+) and BR(B^0arrow μ^+ μ^-K^*0). ^ Supported by U.S. DOE DE-AC02-76CH03000. ^*We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Instituto Nazionale di Fisica Nucleare; the Ministry of Education, Science and Culture of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; and the A. P. Sloan Foundation.

Analyses of {ital D}{sup +}{r_arrow}{ital K}{sup 0}{sub {ital S}}{ital K}{sup +} and {ital D}{sup +}{r_arrow}{ital K}{sup 0}{sub {ital S}}{pi}{sup +}

Energy Technology Data Exchange (ETDEWEB)

Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.; Menon, N.; Miller, D.; Shibata, E.; Shipsey, I.; Yurko, M.; Kwak, N. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Johnson, S.; Kwon, Y.; Roberts, S.; Thorndike, E. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.; Lingel, K.; Marsiske, H.; Perl, M.; Schaffner, S.; Ugolini, D.; Wang, R.; Zhou, X.; Severini, H.; Wappler, F. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; Stroynowski, R.; Volobouev, I.; Ye, J. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Efimov, A.; Frasconi, F.; Gao, M.; Goldberg, M.; He, D.; Kopp, S.; Moneti, G.; Mountain, R.; Mukhin, Y.; Schuh, S.; Skwarnicki, T.; Stone, S.; Viehhauser, G.; Xing, X. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.; Jain, V.; Marka, S. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Freyberger, A.; Gibaut, D.; Godang, R.; Kinoshita, K.; Lai, I.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L. [Wayne State University, Detroit, Michigan 48202 (United States); Barish, B.; Chadha, M.; Chan, S.; Eigen, G.; Miller, J.; OGrady, C.; Schmidtler, M.; Urheim, J.; Weinstein, A.; Wuerthwein, F. [California Institute of Technology, Pasadena, California 91125 (United States); Asner, D.; Bliss, D.; Brower, W.; Masek, G.; Paar, H.; Sharma, V. [University of California, San Diego, La Jolla, California 92093 (United States); Gronberg, J.; Kutschke, R.; Lange, D.; Menary, S.; Morrison, R.; Nelson, H.; Nelson, T.; Qiao, C.; Richman, J.; Roberts, D.; Ryd, A.; Witherell, M. [University of California, Santa Barbara, California 93106 (United States)

1997-04-01

Using data collected with the CLEO II detector at the Cornell Electron Storage Ring, we present new measurements of the branching fractions for D{sup +}{r_arrow}K{sub S}K{sup +} and D{sup +}{r_arrow}K{sub S}{pi}{sup +}. These results are combined with other CLEO measurements to extract the ratios of isospin amplitudes and phase shifts for D{r_arrow}KK and D{r_arrow}K{pi}. {copyright} {ital 1997} {ital The American Physical Society}

Measuring effects of voluntary attention: a comparison among predictive arrow, colour, and number cues.

Science.gov (United States)

Olk, Bettina; Tsankova, Elena; Petca, A Raisa; Wilhelm, Adalbert F X

2014-10-01

The Posner cueing paradigm is one of the most widely used paradigms in attention research. Importantly, when employing it, it is critical to understand which type of orienting a cue triggers. It has been suggested that large effects elicited by predictive arrow cues reflect an interaction of involuntary and voluntary orienting. This conclusion is based on comparisons of cueing effects of predictive arrows, nonpredictive arrows (involuntary orienting), and predictive numbers (voluntary orienting). Experiment 1 investigated whether this conclusion is restricted to comparisons with number cues and showed similar results to those of previous studies, but now for comparisons to predictive colour cues, indicating that the earlier conclusion can be generalized. Experiment 2 assessed whether the size of a cueing effect is related to the ease of deriving direction information from a cue, based on the rationale that effects for arrows may be larger, because it may be easier to process direction information given by symbols such as arrows than that given by other cues. Indeed, direction information is derived faster and more accurately from arrows than from colour and number cues in a direction judgement task, and cueing effects are larger for arrows than for the other cues. Importantly though, performance in the two tasks is not correlated. Hence, the large cueing effects of arrows are not a result of the ease of information processing, but of the types of orienting that the arrows elicit.

First Observations of {Upsilon}(1S) {r_arrow} {gamma}{pi}{sup +}{pi}{sup {minus}} and {Upsilon}(1S) {r_arrow} {gamma}{pi}{sup 0}{pi}{sup 0}

Energy Technology Data Exchange (ETDEWEB)

Anastassov, A.; Duboscq, J.E.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Schwarthoff, H.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Richichi, S.J.; Severini, H.; Skubic, P.; Undrus, A. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Chen, S.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P. [Purdue University, West Lafayette, Indiana 47907 (United States); Glenn, S.; Kwon, Y.; Lyon, A.L.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Savinov, V.; Ugolini, D.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Stroynowski, R.; Ye, J.; Wlodek, T. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Dambasuren, E.; Kopp, S.; Moneti, G.C.; Mountain, R.; Schuh, S.; Skwarnicki, T.; Stone, S.; Titov, A.; Viehhauser, G.; Wang, J.C. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; McLean, K.W.; Marka, S.; Xu, Z. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Godang, R.; Kinoshita, K.; Lai, I.C.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L.P.; Zhou, G.J. [Wayne State University, Detroit, Michigan 48202 (United States); Chan, S.; Eigen, G.; Lipeles, E.; Miller, J.S.; Schmidtler, M.; Shapiro, A.; Sun, W.M.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F. [California Institute of Technology, Pasadena, California 91125 (United States); Jaffe, D.E.; Masek, G.; Paar, H.P.; Potter, E.M.; Prell, S.; Sharma, V. [University of California, San Diego, La Jolla, California 92093 (United States); and others

1999-01-01

We report on a study of exclusive radiative decays of the {Upsilon}(1S) resonance collected with the CLEOthinspthinspII detector operating at the Cornell Electron Storage Ring. We present the first observation of the radiative decays {Upsilon}(1S){r_arrow}{gamma}{pi}{sup +}{pi}{sup {minus}} and {Upsilon}(1S){r_arrow}{gamma}{pi}{sup 0}{pi}{sup 0} . For the dipion mass regime m{sub {pi}{pi}}{gt}1.0 GeV , we obtain B({Upsilon}(1S){r_arrow}{gamma}{pi}{sup +}{pi}{sup {minus}})=(6.3{plus_minus}1.2{plus_minus} 1.3){times}10{sup {minus}5} and B({Upsilon}(1S){r_arrow}{gamma}{pi}{sup 0}{pi}{sup 0})=(1.7{plus_minus}0.6{plus_minus} 0.3){times}10{sup {minus}5} . {copyright} {ital 1999} {ital The American Physical Society }

Arrow Lakes Reservoir Fertilization Experiment; Years 4 and 5, Technical Report 2002-2003.

Energy Technology Data Exchange (ETDEWEB)

Schindler, E.

2007-02-01

This report presents the fourth and fifth year (2002 and 2003, respectively) of a five-year fertilization experiment on the Arrow Lakes Reservoir. The goal of the experiment was to increase kokanee populations impacted from hydroelectric development on the Arrow Lakes Reservoir. The impacts resulted in declining stocks of kokanee, a native land-locked sockeye salmon (Oncorhynchus nerka), a key species of the ecosystem. Arrow Lakes Reservoir, located in southeastern British Columbia, has undergone experimental fertilization since 1999. It is modeled after the successful Kootenay Lake fertilization experiment. The amount of fertilizer added in 2002 and 2003 was similar to the previous three years. Phosphorus loading from fertilizer was 52.8 metric tons and nitrogen loading from fertilizer was 268 metric tons. As in previous years, fertilizer additions occurred between the end of April and the beginning of September. Surface temperatures were generally warmer in 2003 than in 2002 in the Arrow Lakes Reservoir from May to September. Local tributary flows to Arrow Lakes Reservoir in 2002 and 2003 were generally less than average, however not as low as had occurred in 2001. Water chemistry parameters in select rivers and streams were similar to previous years results, except for dissolved inorganic nitrogen (DIN) concentrations which were significantly less in 2001, 2002 and 2003. The reduced snow pack in 2001 and 2003 would explain the lower concentrations of DIN. The natural load of DIN to the Arrow system ranged from 7200 tonnes in 1997 to 4500 tonnes in 2003; these results coincide with the decrease in DIN measurements from water samples taken in the reservoir during this period. Water chemistry parameters in the reservoir were similar to previous years of study except for a few exceptions. Seasonal averages of total phosphorus ranged from 2.11 to 7.42 {micro}g/L from 1997 through 2003 in the entire reservoir which were indicative of oligo-mesotrophic conditions

The location-, word-, and arrow-based Simon effects: An ex-Gaussian analysis.

Science.gov (United States)

Luo, Chunming; Proctor, Robert W

2018-04-01

Task-irrelevant spatial information, conveyed by stimulus location, location word, or arrow direction, can influence the response to task-relevant attributes, generating the location-, word-, and arrow-based Simon effects. We examined whether different mechanisms are involved in the generation of these Simon effects by fitting a mathematical ex-Gaussian function to empirical response time (RT) distributions. Specifically, we tested whether which ex-Gaussian parameters (μ, σ, and τ) show Simon effects and whether the location-, word, and arrow-based effects are on different parameters. Results show that the location-based Simon effect occurred on mean RT and μ but not on τ, and a reverse Simon effect occurred on σ. In contrast, a positive word-based Simon effect was obtained on all these measures (including σ), and a positive arrow-based Simon effect was evident on mean RT, σ, and τ but not μ. The arrow-based Simon effect was not different from the word-based Simon effect on τ or σ but was on μ and mean RT. These distinct results on mean RT and ex-Gaussian parameters provide evidence that spatial information conveyed by the various location modes are different in the time-course of activation.

Of arrows and flows. Causality, determination, and specificity in the Central Dogma of molecular biology.

Science.gov (United States)

Fantini, Bernardino

2006-01-01

From its first proposal, the Central Dogma had a graphical form, complete with arrows of different types, and this form quickly became its standard presentation. In different scientific contexts, arrows have different meanings and in this particular case the arrows indicated the flow of information among different macromolecules. A deeper analysis illustrates that the arrows also imply a causal statement, directly connected to the causal role of genetic information. The author suggests a distinction between two different kinds of causal links, defined as 'physical causality' and 'biological determination', both implied in the production of biological specificity.

New Measurement of {ital B} {r_arrow} {ital D}{sup {asterisk}}{ital {pi}} Branching Fractions

Energy Technology Data Exchange (ETDEWEB)

Brandenburg, G.; Briere, R.A.; Gao, Y.S.; Kim, D.Y.; Wilson, R.; Yamamoto, H. [Harvard University, Cambridge, Massachusetts 02138 (United States); Browder, T.E.; Li, F.; Li, Y.; Rodriguez, J.L. [University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Champaign-Urbana, Illinois 61801 (United States); Edwards, K.W.; Edwards, K.W. [the Institute of Particle Physics (Canada); Bellerive, A.; Bellerive, A.; Janicek, R.; Janicek, R.; MacFarlane, D.B.; MacFarlane, D.B.; McLean, K.W.; McLean, K.W.; Patel, P.M.; Patel, P.M. [the Institute of Particle Physics (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lattery, M.; Lee, S.J.; ONeill, J.J.; Patton, S.; Poling, R.; Riehle, T.; Savinov, V.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Blinov, S.; Duboscq, J.E.; Fisher, K.D.; Fujino, D.; Fulton, R.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P.; Wood, M. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States)

1998-03-01

The decays {Upsilon}(4S){r_arrow}B{ovr B} , followed by B{r_arrow}D{sup {asterisk}}{pi} and D{sup {asterisk}}{r_arrow}D{pi} , permit reconstruction of all kinematic quantities that describe the sequence without reconstruction of the D , with reasonably low backgrounds. Using an integrated e{sup +}e{sup {minus}} luminosity of 3.1 fb{sup {minus}1} accumulated at the {Upsilon}(4S) by the CLEO-II detector, we report measurements of B({ovr B}{sup 0}{r_arrow} D{sup {asterisk}+}{pi}{sup {minus}})=(2.81{plus_minus} 0.11{plus_minus}0.21{plus_minus}0.05){times}10{sup {minus}3} and B(B{sup {minus}}{r_arrow}D{sup {asterisk}0}{pi}{sup {minus}})=(4.34{plus_minus}0.33{plus_minus}0.34{plus_minus}0.1 8){times}10{sup {minus}3} . {copyright} {ital 1998} {ital The American Physical Society}

Battling Arrow's Paradox to Discover Robust Water Management Alternatives

Science.gov (United States)

Kasprzyk, J. R.; Reed, P. M.; Hadka, D.

2013-12-01

This study explores whether or not Arrow's Impossibility Theorem, a theory of social choice, affects the formulation of water resources systems planning problems. The theorem discusses creating an aggregation function for voters choosing from more than three alternatives for society. The Impossibility Theorem is also called Arrow's Paradox, because when trying to add more voters, a single individual's preference will dictate the optimal group decision. In the context of water resources planning, our study is motivated by recent theoretical work that has generalized the insights for Arrow's Paradox to the design of complex engineered systems. In this framing of the paradox, states of society are equivalent to water planning or design alternatives, and the voters are equivalent to multiple planning objectives (e.g. minimizing cost or maximizing performance). Seen from this point of view, multi-objective water planning problems are functionally equivalent to the social choice problem described above. Traditional solutions to such multi-objective problems aggregate multiple performance measures into a single mathematical objective. The Theorem implies that a subset of performance concerns will inadvertently dictate the overall design evaluations in unpredictable ways using such an aggregation. We suggest that instead of aggregation, an explicit many-objective approach to water planning can help overcome the challenges posed by Arrow's Paradox. Many-objective planning explicitly disaggregates measures of performance while supporting the discovery of the planning tradeoffs, employing multiobjective evolutionary algorithms (MOEAs) to find solutions. Using MOEA-based search to address Arrow's Paradox requires that the MOEAs perform robustly with increasing problem complexity, such as adding additional objectives and/or decisions. This study uses comprehensive diagnostic evaluation of MOEA search performance across multiple problem formulations (both aggregated and many

Arrow y Sen: el rescate del individuo y de las instituciones Arrow and Sen: rescuing the individual and institutions

Directory of Open Access Journals (Sweden)

Cante Freddy

1998-12-01

Full Text Available La teoría de la elección social que propone Arrow y Sen es una ruptura con los desarrollos hegemónicos de la microeconomía y de la macroeconomía en dos sentidos: rescata la diversidad de gustos y valores de cada individuo en oposición a los conceptos agregados; además, muestra que la conducta racional es quizás lo menos importante con lo que abre un diálogo con la economía institucional.The theory of social choice proposed by Arrow and Sen breaks with the hegemonic developments of microeconomics and macroeconomics in two senses: it rescues the diversity of tastes and values of each individual as opposed to aggregated concepts, and in addition it shows that rational behavior is perhaps the least important kind, which opens up a dialogue with institutional economics.

References and arrow notation instead of join operation in query languages

Directory of Open Access Journals (Sweden)

Alexandr Savinov

2012-10-01

Full Text Available We study properties of the join operation in query languages and describe some of its major drawbacks. We provide strong arguments against using joins as a main construct for retrieving related data elements in general purpose query languages and argue for using references instead. Since conventional references are quite restrictive when applied to data modeling and query languages, we propose to use generalized references as they are defined in the concept-oriented model (COM. These references are used by two new operations, called projection and de-projection, which are denoted by right and left arrows and therefore this access method is referred to as arrow notation. We demonstrate advantages of the arrow notation in comparison to joins and argue that it makes queries simpler, more natural, easier to understand, and the whole query writing process more productive and less error-prone.

Transfer entropy in physical systems and the arrow of time

Science.gov (United States)

Spinney, Richard E.; Lizier, Joseph T.; Prokopenko, Mikhail

2016-08-01

Recent developments have cemented the realization that many concepts and quantities in thermodynamics and information theory are shared. In this paper, we consider a highly relevant quantity in information theory and complex systems, the transfer entropy, and explore its thermodynamic role by considering the implications of time reversal upon it. By doing so we highlight the role of information dynamics on the nuanced question of observer perspective within thermodynamics by relating the temporal irreversibility in the information dynamics to the configurational (or spatial) resolution of the thermodynamics. We then highlight its role in perhaps the most enduring paradox in modern physics, the manifestation of a (thermodynamic) arrow of time. We find that for systems that process information such as those undergoing feedback, a robust arrow of time can be formulated by considering both the apparent physical behavior which leads to conventional entropy production and the information dynamics which leads to a quantity we call the information theoretic arrow of time. We also offer an interpretation in terms of optimal encoding of observed physical behavior.

First Observation of the Decay {tau}{sup {minus}} {r_arrow} K{sup {asterisk}{minus}}{eta}{nu}{sub {tau}}

Energy Technology Data Exchange (ETDEWEB)

Bishai, M.; Chen, S.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P. [Purdue University, West Lafayette, Indiana 47907 (United States); Glenn, S.; Kwon, Y.; Lyon, A.L.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Savinov, V.; Ugolini, D.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Stroynowski, R.; Ye, J.; Wlodek, T. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Dambasuren, E.; Kopp, S.; Moneti, G.C.; Mountain, R.; Schuh, S.; Skwarnicki, T.; Stone, S.; Titov, A.; Viehhauser, G.; Wang, J.C. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; McLean, K.W.; Marka, S.; Xu, Z. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Godang, R.; Kinoshita, K.; Lai, I.C.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L.P.; Zhou, G.J. [Wayne State University, Detroit, Michigan 48202 (United States); Chan, S.; Eigen, G.; Lipeles, E.; Miller, J.S.; Schmidtler, M.; Shapiro, A.; Sun, W.M.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F. [California Institute of Technology, Pasadena, California 91125 (United States); Jaffe, D.E.; Masek, G.; Paar, H.P.; Potter, E.M.; Prell, S.; Sharma, V. [University of California, San Diego, La Jolla, California 92093 (United States); Asner, D.M.; Gronberg, J.; Hill, T.S.; Lange, D.J.; Morrison, R.J.; Nelson, H.N.; Nelson, T.K.; Roberts, D. [University of California, Santa Barbara, California 93106 (United States); Behrens, B.H.; Ford, W.T.; Gritsan, A.; Krieg, H.; Roy, J.; Smith, J.G. [Univ. of Colorado, Boulder, Colorado 80309-0390 (United States)

1999-01-01

The decay {tau}{sup {minus}}{r_arrow}K{sup {asterisk}{minus}}{eta}{nu}{sub {tau}} has been observed with the CLEOthinspthinspII detector. The K{sup {asterisk}{minus}} is reconstructed in two decay channels, K{sup {asterisk}{minus}}{r_arrow}K{sub S}{pi}{sup {minus}}{r_arrow} {pi}{sup {minus}}{pi}{sup +}{pi}{sup {minus}} and K{sup {asterisk}{minus}}{r_arrow}K{sup {minus}}{pi}{sup 0} . The {eta} is reconstructed from the decay {eta}{r_arrow}{gamma}{gamma} . The measured branching fraction is B({tau}{sup {minus}}{r_arrow}K{sup {asterisk}{minus}} {eta}{nu}{sub {tau}})=(2.9{plus_minus} 0.8{plus_minus}0.4){times}10{sup {minus}4} . We also measure the inclusive branching fractions without requiring the K{sup {asterisk}} resonance, B({tau}{sup {minus}}{r_arrow}K{sub S}{pi}{sup {minus}}{eta}{nu}{sub {tau}})=(1.10 {plus_minus}0.35{plus_minus}0.11){times}10{sup {minus}4} and B({tau}{sup {minus}}{r_arrow}K{sup {minus}}{pi}{sup 0}{eta}{nu}{sub {tau}})=(1.77 {plus_minus}0.56{plus_minus}0.71){times}10{sup {minus}4} . The results indicate that the K{sup {asterisk}{minus}} resonance dominates the K{sub S}{pi}{sup {minus}} mass spectrum. {copyright} {ital 1999} {ital The American Physical Society}

ARTHROSCOPIC MENISCUS REPAIR WITH BIOABSORBABLE ARROWS IN LOCAL ANESTHESIA

Directory of Open Access Journals (Sweden)

Vladimir Senekovič

2004-11-01

Full Text Available Background. The menisci have important function in the knee joint. Because of this it is universally accepted that we have to preserve them as much as possible. After open and partially arthroscopic suture techniques new methods of all-inside meniscus repair with bioabsorbable arrows have been developed in the last decade. The meniscus repair using these arrows represents an easy task for a skilled surgeon. In addition, it can be performed in local anesthesia. We have evaluated the results of the first group of patients who were treated by this method.Methods. From February 2001 to August 2002 15 patients with torn meniscuses have been treated at the Clinical Department for Traumatology, University Medical centre, Ljubljana. We repaired their torn menisci arthroscopically with bioabsorbable arrows in local anesthesia. We divided patients in three groups: a group with isolated meniscus injury, a group with meniscus injury and anterior cruciate ligament injury and a group with associated pathology. Four patients had incarcerated meniscuses. Preoperative Lysholm score in the first group was 38, in the second 42 and in the third group 48. We repaired 12 medial and 3 lateral meniscuses. On average we need 45 minutes for therapeutic arthroscopy. Torn meniscus was fixated with minimum of 1 and maximum of 5 bioabsorbable arrows. All patients except one had the affected knee immobilized with cylinder plaster for 15 days on average.Results. At least three months after the arthroscopic fixation of the torn meniscus in local anesthesia another clinical evaluation was made. In all groups significant improvement was observed regarding the range of motions and absence of pain. Postoperative Lysholm score in the first group was 89, in the second 75 and in the third 71. Average deficit of flexion was 3 degrees while extension was full. One patient complained about the same pain in the joint, he underwent another arthroscopy which showed that the meniscus was

Pycellerator: an arrow-based reaction-like modelling language for biological simulations.

Science.gov (United States)

Shapiro, Bruce E; Mjolsness, Eric

2016-02-15

We introduce Pycellerator, a Python library for reading Cellerator arrow notation from standard text files, conversion to differential equations, generating stand-alone Python solvers, and optionally running and plotting the solutions. All of the original Cellerator arrows, which represent reactions ranging from mass action, Michales-Menten-Henri (MMH) and Gene-Regulation (GRN) to Monod-Wyman-Changeaux (MWC), user defined reactions and enzymatic expansions (KMech), were previously represented with the Mathematica extended character set. These are now typed as reaction-like commands in ASCII text files that are read by Pycellerator, which includes a Python command line interface (CLI), a Python application programming interface (API) and an iPython notebook interface. Cellerator reaction arrows are now input in text files. The arrows are parsed by Pycellerator and translated into differential equations in Python, and Python code is automatically generated to solve the system. Time courses are produced by executing the auto-generated Python code. Users have full freedom to modify the solver and utilize the complete set of standard Python tools. The new libraries are completely independent of the old Cellerator software and do not require Mathematica. All software is available (GPL) from the github repository at https://github.com/biomathman/pycellerator/releases. Details, including installation instructions and a glossary of acronyms and terms, are given in the Supplementary information. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

A Driving Simulator Evaluation of Red Arrows and Flashing Yellow Arrows in Right-Turn Applications : Establishing the Foundation for Future Research

Science.gov (United States)

2017-11-01

Driver understanding of flashing yellow arrow (FYA) indications for left turns has been studied extensively; however, the use of FYA for right-turn applications is an area that needs to be better understood through evaluations focused on actual drive...

Tragic Paradox in Achebe's "Arrow of God"

Science.gov (United States)

Soile, Sola

1976-01-01

Leads into a discussion of Chinua Achebe's "Arrow of God" (1964) from his earlier novel "Things Fall Apart" (1958), because such a comparative approach provides an opportunity to see Achebe's elaboration and development of a subject that is obviously dear to his heart, namely, the trials and tribulations of a dynamic society as…

Atypical Visual Orienting to Gaze- and Arrow-Cues in Adults with High Functioning Autism

Science.gov (United States)

Vlamings, Petra H. J. M.; Stauder, Johannes E. A.; van Son, Ilona A. M.; Mottron, Laurent

2005-01-01

The present study investigates visual orienting to directional cues (arrow or eyes) in adults with high functioning autism (n = 19) and age matched controls (n = 19). A choice reaction time paradigm is used in which eye-or arrow direction correctly (congruent) or incorrectly (incongruent) cues target location. In typically developing participants,…

Geochemistry of the Oruatemanu Formation, Arrow Rocks, Northland, New Zealand

International Nuclear Information System (INIS)

Hori, R.S.; Higuchi, Y.; Fujiki, T.; Maeda, T.; Ikehara, M.

2007-01-01

We investigated the geochemical characteristics of sedimentary rocks from the Upper Permian - Middle Triassic Oruatemanu Formation on Arrow Rocks, Waipapa Terrane, New Zealand. The sedimentary rocks consist of limestone, tuffaceous shale, vari-coloured bedded chert, hemipelagic shale and green siliceous mudstone (= green argillite), in ascending order, a typical oceanic plate sequence. Shale and green argillite have higher Zr/Nb ratios than do chert and tuffaceous shales, and show similar REE patterns to PAAS (Post-Archean average Australian shale). In contrast, chert sequences from the basal part and intercalated tuff layers have high TiO 2 contents and Zr/Nb ratios similar to those of basaltic rocks from Arrow Rocks. These geochemical characteristics suggest that the sedimentary environment of the Oruatemanu Formation changed upward, from an open sea setting to the continental margin of Gondwanaland. Chemical compositions of bedded cherts from Arrow Rocks indicate a mixing of biogenic silica, detritus from continents and basaltic materials. In the interval from Upper Permian to Lower Middle Triassic this mixing shows remarkable secular variations. We detected geochemical signals of two Oceanic Anoxic Events (OAEs), one at the Permian/Triassic (P/T) boundary, and the other at the middle Upper Induan level. We name them the OAEα (P/T OAE) and OAEβ (Upper Induan OAE). These OAE horizons are enriched in S, U and other heavy metals (e.g. Mo and Cr), and also have high V/(V+Ni) ratios. Based on a comparison between enrichment factors of Cr and other redox-sensitive trace elements (e.g. Zn, Pb, Co, Cu), the Upper Induan OAEβ is considered to be more intense than the P/T boundary OAEα. This result is not in agreement with the superanoxia model previously proposed. In addition, OAEβ corresponds well with the radiolarian faunal turnover from Permian to Triassic forms documented from the Oruatemanu Formation in this volume. These results may suggest that peak time and

ARROW (Version 2) Commercial Software Validation and Configuration Control

Energy Technology Data Exchange (ETDEWEB)

HEARD, F.J.

2000-02-10

ARROW (Version 2), a compressible flow piping network modeling and analysis computer program from Applied Flow Technology, was installed for use at the U.S. Department of Energy Hanford Site near Richland, Washington.

ARROW (Version 2) Commercial Software Validation and Configuration Control

International Nuclear Information System (INIS)

HEARD, F.J.

2000-01-01

ARROW (Version 2), a compressible flow piping network modeling and analysis computer program from Applied Flow Technology, was installed for use at the U.S. Department of Energy Hanford Site near Richland, Washington

Logical and historical determination of the Arrow and Sen impossibility theorems

Directory of Open Access Journals (Sweden)

Boričić Branislav

2007-01-01

Full Text Available General classification of mathematical statements divides them into universal, those of the form xA , and existential ЭxA ones. Common formulations of impossibility theorems of K. J. Arrow and A. K. Sen are represented by the statements of the form "there is no x such that A". Bearing in mind logical equivalence of formulae ¬ЭxA and x¬A, we come to the conclusion that the corpus of impossibility theorems, which appears in the theory of social choice, could make a specific and recognizable subclass of universal statements. In this paper, on the basis of the established logical and methodological criteria, we point to a sequence of extremely significant "impossibility theorems", reaching throughout the history of mathematics to the present days and the famous results of Arrow and Sen in field of mathematical economics. We close with specifying the context which makes it possible to formulate the results of Arrow and Sen accurately, presenting a new direct proof of Sen’s result, with no reliance on the notion of minimal liberalism. .

Class Struggle in Contemporary Films: "Hunger Games" vs. "Arrow, The Ultimate Weapon"

Directory of Open Access Journals (Sweden)

Dal Yong Jin

2016-05-01

Full Text Available By critically engaging with Marxist notion of class struggle in contemporary films utilizing the bow and arrow as their signifier, this paper textually analyzes two films in order to find distinctive characteristics of Western movies and non-Western movies. Since the textual analysis becomes very important to understanding how media texts might be used in order to make sense of the world we live in—meaning it is significant to contextualize it within our life and/or society, this paper investigates the ways in which the major themes have developed and what their representations are. It therefore compares and contrasts these movies in terms of their major themes, in particular the ways in which these two films portray capitalism, either internally or externally. It especially examines how the bow and arrow symbolize class struggle either within a country or between countries in order to map out the major differences that the arrows represent.

Does quantum electrodynamics have an arrow of time?

NARCIS (Netherlands)

Atkinson, David

Quantum electrodynamics is a time-symmetric theory that is part of the electroweak interaction, which is invariant under a generalized form of this symmetry, the PCT transformation. The thesis is defended that the arrow of time in electrodynamics is a consequence of the assumption of an initial

The dark arrow of time a scientific novel

CERN Document Server

Villata, Massimo

2017-01-01

This riveting scientific novel combines adventure, love, suspense, magic, pathos, and mystery in a carefully woven plot that is full of unexpected twists and turns. The author is an astrophysicist who has developed an alternative theory, which holds that traveling in time is possible. Time is, in fact, the real protagonist of the novel and of the intrigue surrounding the attempt to seize the secret of Time’s other arrow, the dark arrow normally hidden from us, which points back at our past. The underlying premise is that antimatter is nothing more than common matter moving backwards in time. The justification for this interpretation has been with us for some time, “hiding in plain sight” within Maxwell’s equations, the Lorentz transformations, the CPT theorem of relativistic quantum mechanics, and Feynman diagrams. While the science underlying the narrative is explained whenever necessary, sometimes with the aid of simple mathematical formulas, these scientific asides account for only a small part of ...

Time's arrow: A numerical experiment

Science.gov (United States)

Fowles, G. Richard

1994-04-01

The dependence of time's arrow on initial conditions is illustrated by a numerical example in which plane waves produced by an initial pressure pulse are followed as they are multiply reflected at internal interfaces of a layered medium. Wave interactions at interfaces are shown to be analogous to the retarded and advanced waves of point sources. The model is linear and the calculation is exact and demonstrably time reversible; nevertheless the results show most of the features expected of a macroscopically irreversible system, including the approach to the Maxwell-Boltzmann distribution, ergodicity, and concomitant entropy increase.

The arrows of time a debate in cosmology

CERN Document Server

Mersini-Houghton, Laura

2012-01-01

The concept of time has fascinated humanity throughout history, and remains one of the biggest mysteries in science and philosophy. Yet a deeper understanding of nature at a fundamental level can only be achieved through a comprehension of this strange fourth dimension. Furthermore, the origin of the universe is closely intertwined with the puzzle of time: Did time emerge at the big bang? Why does the direction of time ‘conspire’ with the remarkably ordered initial state of the universe? This book addresses many of the most important questions about time: What is time, and is it fundamental or emergent? Why is there such an arrow of time, closely related to the initial state of the universe, and why do the cosmic, thermodynamic and other arrows agree? These issues are discussed here by leading experts, and each offers a new perspective on the debate. Their contributions delve into the most difficult research topic in physics, also describing the latest cutting edge research on the subject. The book also...

Measurement of the {ovr {ital B}} {r_arrow} {ital Dl}{ovr {nu} } Partial Width and Form Factor Parameters

Energy Technology Data Exchange (ETDEWEB)

Athanas, M.; Avery, P.; Jones, C.D.; Lohner, M.; Prescott, C.; Yelton, J.; Zheng, J. [University of Florida, Gainesville, Florida 32611 (United States); Brandenburg, G.; Briere, R.A.; Ershov, A.; Gao, Y.S.; Kim, D.Y.; Wilson, R.; Yamamoto, H. [Harvard University, Cambridge, Massachusetts 02138 (United States); Browder, T.E.; Li, F.; Li, Y.; Rodriguez, J.L. [University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Champaign-Urbana, Illinois 61801 (United States); Edwards, K.W.; Edwards, K.W. [the Institute of Particle Physics (Canada); Bellerive, A.; Bellerive, A.; Janicek, R.; Janicek, R.; MacFarlane, D.B.; MacFarlane, D.B.; Patel, P.M.; Patel, P.M. [the Institute of Particle Physics (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lee, S.J.; ONeill, J.J.; Patton, S.; Poling, R.; Riehle, T.; Savinov, V.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Blinov, S.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; and others

1997-09-01

We have studied the decay {bar B}{r_arrow}Dl{bar {nu}} , where l=e or {mu} . From a fit to the differential decay rate d{Gamma}/dw we measure the rate normalization F{sub D}(1){vert_bar}V{sub cb}{vert_bar} and form factor slope {cflx {rho}}{sup 2}{sub D} , and, using measured values of {tau}{sub B} , find {Gamma}({bar B}{r_arrow}Dl{bar {nu}}) = (12.0{plus_minus}0.9{plus_minus}2.1) ns{sup {minus}1}. The resulting branching fractions are B({bar B}{sup 0}{r_arrow}D{sup +}l{sup {minus}}{bar {nu}})=(1.87{plus_minus}0.15{plus_minus} 0.32){percent} and B(B{sup {minus}}{r_arrow}D{sup 0} l{sup {minus}}{bar {nu}})=(1.94{plus_minus}0.15{plus_minus}0.34){percent} . The form factor parameters are in agreement with those measured in {bar B}{r_arrow}D{sup *}l{bar {nu}} decays, as predicted by heavy quark effective theory. {copyright} {ital 1997} {ital The American Physical Society}

Recent developments in the field of arrow and dart poisons.

Science.gov (United States)

Philippe, Geneviève; Angenot, Luc

2005-08-22

Arrow and dart poisons, considered as conventional natural sources for future drug discovery, have already provided numerous biologically active molecules used as drugs in therapeutic applications or in pharmacological research. Plants containing alkaloids or cardiotonic glycosides have generally been the main ingredients responsible for the efficacy of these poisons, although some animals, such as frogs, have also been employed. This paper, without being exhaustive, reports the greater strides made during the past 15 years in the understanding of the chemical nature and biological properties of arrow and dart poison constituents. Examples both of promising biological properties shown by these molecules and of crucial discoveries achieved by their use as pharmacological tools are given. Further studies of these toxic principles are likely to enable scientists to find new valuable lead compounds, useful in many fields of research, like oncology, inflammation and infectious diseases.

Stochasticity, decoherence and an arrow of time from the ...

Indian Academy of Sciences (India)

Certain intriguing consequences of the discreteness of time on the time evolution of dynamical systems are discussed. In the discrete-time classical mechanics proposed here, there is an arrow of time that follows from the fact that the replacement of the time derivative by the backward difference operator alone can preserve ...

Recognition of Damaged Arrow-Road Markings by Visible Light Camera Sensor Based on Convolutional Neural Network

Directory of Open Access Journals (Sweden)

Husan Vokhidov

2016-12-01

Full Text Available Automobile driver information as displayed on marked road signs indicates the state of the road, traffic conditions, proximity to schools, etc. These signs are important to insure the safety of the driver and pedestrians. They are also important input to the automated advanced driver assistance system (ADAS, installed in many automobiles. Over time, the arrow-road markings may be eroded or otherwise damaged by automobile contact, making it difficult for the driver to correctly identify the marking. Failure to properly identify an arrow-road marker creates a dangerous situation that may result in traffic accidents or pedestrian injury. Very little research exists that studies the problem of automated identification of damaged arrow-road marking painted on the road. In this study, we propose a method that uses a convolutional neural network (CNN to recognize six types of arrow-road markings, possibly damaged, by visible light camera sensor. Experimental results with six databases of Road marking dataset, KITTI dataset, Málaga dataset 2009, Málaga urban dataset, Naver street view dataset, and Road/Lane detection evaluation 2013 dataset, show that our method outperforms conventional methods.

Recognition of Damaged Arrow-Road Markings by Visible Light Camera Sensor Based on Convolutional Neural Network.

Science.gov (United States)

Vokhidov, Husan; Hong, Hyung Gil; Kang, Jin Kyu; Hoang, Toan Minh; Park, Kang Ryoung

2016-12-16

Automobile driver information as displayed on marked road signs indicates the state of the road, traffic conditions, proximity to schools, etc. These signs are important to insure the safety of the driver and pedestrians. They are also important input to the automated advanced driver assistance system (ADAS), installed in many automobiles. Over time, the arrow-road markings may be eroded or otherwise damaged by automobile contact, making it difficult for the driver to correctly identify the marking. Failure to properly identify an arrow-road marker creates a dangerous situation that may result in traffic accidents or pedestrian injury. Very little research exists that studies the problem of automated identification of damaged arrow-road marking painted on the road. In this study, we propose a method that uses a convolutional neural network (CNN) to recognize six types of arrow-road markings, possibly damaged, by visible light camera sensor. Experimental results with six databases of Road marking dataset, KITTI dataset, Málaga dataset 2009, Málaga urban dataset, Naver street view dataset, and Road/Lane detection evaluation 2013 dataset, show that our method outperforms conventional methods.

Recognition of Damaged Arrow-Road Markings by Visible Light Camera Sensor Based on Convolutional Neural Network

Science.gov (United States)

Vokhidov, Husan; Hong, Hyung Gil; Kang, Jin Kyu; Hoang, Toan Minh; Park, Kang Ryoung

2016-01-01

Automobile driver information as displayed on marked road signs indicates the state of the road, traffic conditions, proximity to schools, etc. These signs are important to insure the safety of the driver and pedestrians. They are also important input to the automated advanced driver assistance system (ADAS), installed in many automobiles. Over time, the arrow-road markings may be eroded or otherwise damaged by automobile contact, making it difficult for the driver to correctly identify the marking. Failure to properly identify an arrow-road marker creates a dangerous situation that may result in traffic accidents or pedestrian injury. Very little research exists that studies the problem of automated identification of damaged arrow-road marking painted on the road. In this study, we propose a method that uses a convolutional neural network (CNN) to recognize six types of arrow-road markings, possibly damaged, by visible light camera sensor. Experimental results with six databases of Road marking dataset, KITTI dataset, Málaga dataset 2009, Málaga urban dataset, Naver street view dataset, and Road/Lane detection evaluation 2013 dataset, show that our method outperforms conventional methods. PMID:27999301

First measurement of the rate for the inclusive radiative penguin decay {ital b}{r_arrow}{ital s}{gamma}

Energy Technology Data Exchange (ETDEWEB)

Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Daubenmier, C.M.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Butler, F.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; McIlwain, R.L.; Miao, T.; Miller, D.H.; Modesitt, M.; Payne, D.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Battle, M.; Ernst, J.; Gibbons, L.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Wang, C.H.; Coan, T.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Rozen, Y.; Stone, S.; Xing, X.; Zhu, G.; Bartelt, J.; Csorna, S.E.; Egyed, Z.; Jain, V.; Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Barish, B.; Chadha, M.; Chan, S.; Cowen, D.F.; Eigen, G.; Miller, J.S.; O`Grady, C.; Urheim, J.; Weinstein, A.J.; Athanas, M.; Brower, W.; Masek, G.; Paar, H.P.; Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Ryd, A.; Sperka, D.; Tajima, H.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Johnson, D.R.; Lingel, K.; Lohner, M.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Gaidarev, P.; Garcia-Sciveres, M.; Geiser, B.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Salman, S.; Sapper, M.; Wuerthwein, F.; Avery, P.; Freyberger, A.; Rodriguez, J.; (CLEO Co...

1995-04-10

We have measured the inclusive {ital b}{r_arrow}{ital s}{gamma} branching ratio to be (2.32{plus_minus}0.57{plus_minus}0.35){times}10{sup {minus}4}, where the first error is statistical and the second is systematic. Upper and lower limits on the branching ratio, each at 95% C.L., are {ital B}({ital b}{r_arrow}{ital s}{gamma}){lt}4.2{times}10{sup {minus}4} and {ital B}({ital b}{r_arrow}{ital s}{gamma}){gt}1.0{times}10{sup {minus}4}. These limits restrict the parameters of extensions of the standard model.

Elliptical Orbit [arrow right] 1/r[superscript 2] Force

Science.gov (United States)

Prentis, Jeffrey; Fulton, Bryan; Hesse, Carol; Mazzino, Laura

2007-01-01

Newton's proof of the connection between elliptical orbits and inverse-square forces ranks among the "top ten" calculations in the history of science. This time-honored calculation is a highlight in an upper-level mechanics course. It would be worthwhile if students in introductory physics could prove the relation "elliptical orbit" [arrow right]…

Though Arrow Says It’s Impossible, It Happens Everyday

OpenAIRE

Mohammad Gani

2004-01-01

Arrow’s Impossibility Theorem shows that transitive social preference is impossible. This note shows that in the general case of exchange, social preference need not be transitive. Indeed, it shows that social preference must be non-transitive to allow gainful exchange to maximize social welfare. Thus though Arrow says it is impossible, it actually happens everyday and everywhere.

Observation of the Cabibbo-suppressed charmed baryon decay {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital p}{phi}

Energy Technology Data Exchange (ETDEWEB)

Alexander, J.P.; Bebek, C.; Berger, B.E.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Dickson, M.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Elia, R.; Gaidarev, P.; Garcia-Sciveres, M.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Lee, T.; Liu, Y.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Soffer, A.; Avery, P.; Freyberger, A.; Lingel, K.; Prescott, C.; Rodriguez, J.; Yang, S.; Yelton, J.; Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; ONeill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Kopp, S.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.

1996-02-01

We report the observation of the Cabibbo-suppressed decays {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital pK{sup {minus}}K{sup +}} and {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital p}{phi} using data collected with the CLEO II detector at CESR. The latter mode, observed for the first time with significant statistics, is of interest as a test of color suppression in charm decays. We have determined the branching ratios for these modes relative to {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital pK{sup {minus}}}{pi}{sup +} and compared our results with theory. {copyright} {ital 1996 The American Physical Society.}

The generic nature of the global and non-entropic arrow of time and the dual role of the energy-momentum tensor

Energy Technology Data Exchange (ETDEWEB)

Castagnino, Mario [CONICET-Instituto de AstronomIa y FIsica del Espacio, Casilla de Correos 67, Sucursal 28, 1428 Buenos Aires (Argentina); Lombardi, Olimpia [CONICET-Universidad Autonoma de Madrid, Ctra. Colmenar Km 15, 28049 Madrid (Spain)

2004-04-16

In this paper we adopt a generic, global and non-entropic approach to the problem of the arrow of time, according to which the arrow of time is a generic, intrinsic and geometrical property of spacetime. We demonstrate that the arrow of time so defined is generic in the sense that any spacetime with physically reasonable properties (e.g. time-orientability and global time) will be endowed with an arrow of time. The only exceptions are very special cases belonging to a subset of zero measure of the set of all possible spacetimes. We also show the dual role played by the energy-momentum tensor in the context of our approach. On one hand, the energy-momentum tensor is the intermediate step that permits us to turn the geometrical time-asymmetry of the universe into a local arrow of time manifested as a time-asymmetric energy flow. On the other hand, the energy-momentum tensor supplies the basis for deducing the time-asymmetry of quantum field theory, posed as an axiom in this theory.

Arrow injuries in North Eastern Nigeria | Na'Aya | Port Harcourt ...

African Journals Online (AJOL)

Background: Arrow injuries are common presentation at the Federal Medical Centre (FMC), Nguru, North East Nigeria. The injuries are mostly unreported and there is neither a policy nor an action plan to curb their incidence. Aim: To establish an accurate data base for this clinical entity in this part of Nigeria and suggest ...

What remains of the Arrow oil?

International Nuclear Information System (INIS)

Sergy, G.; Owens, E.

1993-01-01

In February 1970, the tanker Arrow became grounded 6.5 km off the north shore of Chedabucto Bay, Nova Scotia, and nearly 72,000 bbl of Bunker C fuel oil were released from the vessel during its subsequent breakup and sinking. The oil was washed ashore in various degrees over an estimated 305 km of the bay's 604-km shoreline, of which only 48 km were cleaned. In addition, the tanker Kurdistan broke in two in pack ice in March 1979 in the Cabot Strait area, spilling ca 54,000 bbl of Bunker C, some of which was later found at 16 locations along the northeast and east shorelines of Chedabucto Bay. In summer 1992, a systematic ground survey of the bay's shorelines was conducted using Environment Canada Shoreline Cleanup Assessment Team (SCAT) procedures. Standard observations were made of oil distribution and width, thickness, and character of the oil residues in 419 coastal segments. Results from the survey are summarized. Oil was found to be present on 13.3 km of the shoreline, with heavy oiling restricted to 1.3 km primarily in the areas of Black Duck Cove and Lennox Passage. Some of this residual oil was identified as coming from the Arrow. Natural weathering processes account for removal of most of the spilled oil from the bay. Oil remaining on the shore was found in areas outside of the zone of physical wave action, in areas of nearshore mixing where fine sediments are not present to weather the oil through biophysical processes, or in crusts formed by oil weathered on the surface. The systematic description of oiled shorelines using the SCAT methodology proved very successful, even for such an old spill. 6 refs

Frequency-modulation transient absorption spectrum of the HCCl A 1A double-prime(0,0,0)left-arrow X 1A'(0,0,0) transition

International Nuclear Information System (INIS)

Chang, B.; Sears, T.J.

1995-01-01

The rotationally resolved spectrum of the HCCl A 1 A double-prime(0,0,0)left-arrow X 1 A'(0,0,0) transition between 12 230 and 12 410 cm -1 was obtained for the first time at Doppler-limited resolution using a frequency-modulation (FM) transient absorption technique. Five major subbands (K a =0 left-arrow 1, 1 left-arrow 0, 1 left-arrow 2, 2 left-arrow 1, and 2 left-arrow 3) of HC 35 Cl and one subband (K a =0 left-arrow 1) of HC 37 Cl were observed and assigned. In addition, the forbidden subband (K a =0 left-arrow 0) of HC 35 Cl was also observed. Thus far, we have assigned most (more than 70%) of the strong lines. The analysis of these subbands determines the geometry for the HCCl A(0,0,0) level: angle HCCl=134.7 degree and R C-Cl =1.623 A while R C-H is fixed at the corresponding value of CH 2 . The height of the barrier to linearity was found to be approximately 2170 cm -1 above the vibrationless level of the A state. The rotational structure of this spectrum shows irregular perturbations. Both random and J-dependent (anomalous K-type doubling) effects were observed. As in methylene, the perturbations most likely arise from Renner--Teller effect between the two singlet states in combination with spin--orbit coupling between the singlet and triplet states

Measurement of the ratio of branching fractions {ital B}({ital D}{sup 0}{r_arrow}{pi}{sup {minus}}{ital e}{sup +}{nu}{sub {ital e}})/{ital B}({ital D}{sup 0}{r_arrow}{ital K}{sup {minus}}{ital e}{sup +}{nu}{sub {ital e}})

Energy Technology Data Exchange (ETDEWEB)

Butler, F.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; McIlwain, R.L.; Miao, T.; Miller, D.H.; Modesitt, M.; Payne, D.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Gibbons, L.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Rozen, Y.; Stone, S.; Xing, X.; Zhu, G.; Bartelt, J.; Csorna, S.E.; Egyed, Z.; Jain, V.; Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Barish, B.; Chadha, M.; Chan, S.; Cowen, D.F.; Eigen, G.; Miller, J.S.; O`Grady, C.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F.; Asner, D.M.; Athanas, M.; Bliss, D.W.; Brower, W.S.; Masek, G.; Paar, H.P.; Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Roberts, D.; Ryd, A.; Tajima, H.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Lohner, M.; Park, H.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berger, B.E.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Dickson, M.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Elia, R.; Gaidarev, P.; Garcia-Sciveres, M.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Liu, Y.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Soffer, A.; Avery, P.; Freyberger, A.; Lingel, K.; Rodriguez, J.; Yang, S.; Yelton, J.; Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; (CLEO Collabor...

1995-09-01

Using 3.0 fb{sup {minus}1} of data collected with the CLEO-II detector, we study the Cabibbo-suppressed decay {ital D}{sup 0}{r_arrow}{pi}{sup {minus}}{ital e}{sup +}{nu}{sub {ital e}}. The ratio of the branching fractions {ital B}({ital D}{sup 0}{r_arrow}{pi}{sup {minus}}{ital e}{sup +}{nu}{sub {ital e}})/{ital B}({ital D}{sup 0}{r_arrow}{ital K}{sup {minus}}{ital e}{sup +}{nu}{sub {ital e}}) is measured to be (10.3{plus_minus}3.9{plus_minus}1.3)%, corresponding to an upper limit of 15.6% at the 90% confidence level.

Isospin corrections to charmless semileptonic {ital B}{r_arrow}{ital V} transitions

Energy Technology Data Exchange (ETDEWEB)

Diaz-Cruz, J.L. [Instituto de Fisica, Universidad Autonoma de Puebla, Apartado Postal J-48, 72500 Puebla, Puebla (Mexico); Lopez Castro, G. [Departamento de Fisica, Cinvestav del IPN, Apartado Postal 14-740, 07000 Mexico, D.F. (Mexico); Munoz, J.H. [Departamento de Fisica, Cinvestav del IPN, Apartado Postal 14-740, 07000 Mexico, D.F. (Mexico)]|[Departamento de Fisica, Universidad del Tolima, A. A. 546, Ibague (Colombia)

1996-08-01

We compute isospin corrections to the charmless semileptonic {ital B}{r_arrow}{ital V} transitions arising from {rho}-{omega} mixing and discuss its relevance in the determination of {ital V}{sub {ital ub}}. {copyright} {ital 1996 The American Physical Society.}

Investigating Hemispheric Lateralization of Reflexive Attention to Gaze and Arrow Cues

Science.gov (United States)

Marotta, Andrea; Lupianez, Juan; Casagrande, Maria

2012-01-01

Recent studies have demonstrated that central cues, such as eyes and arrows, reflexively trigger attentional shifts. However, it is not clear whether the attentional mechanisms induced by these two cues are similar or rather differ in some important way. We investigated hemispheric lateralization of the orienting effects induced by the two cue…

Study of gluon versus quark fragmentation in {Upsilon}{r_arrow}gg{gamma} and e{sup +}e{sup {minus}}{r_arrow}q{bar q}{gamma} events at {radical}(s)=10 GeV

Energy Technology Data Exchange (ETDEWEB)

Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Blinov, S.; Duboscq, J.E.; Fujino, D.; Fulton, R.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P.; Wood, M. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Schaffner, S.F.; Ugolini, D.; Wang, R.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; Stroynowski, R.; Volobouev, I.; Ye, J. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Efimov, A.; Frasconi, F.; Gao, M.; Goldberg, M.; He, D.; Kopp, S.; Moneti, G.C.; Mountain, R.; Mukhin, Y.; Schuh, S.; Skwarnicki, T.; Stone, S.; Viehhauser, G.; Xing, X. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; Jain, V.; Marka, S. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Freyberger, A.; Gibaut, D.; Godang, R.; Kinoshita, K.; Lai, I.C.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L.P. [Wayne State University, Detroit, Michigan 48202 (United States); Barish, B.; Chadha, M.; and others

1997-07-01

Using data collected with the CLEO II detector at the Cornell Electron Storage Ring, we determine the ratio R{sub chrg} for the mean charged multiplicity observed in {Upsilon}(1S){r_arrow}gg{gamma} events, {l_angle}n{sub gluon}{sup {plus_minus}}{r_angle}, to the mean charged multiplicity observed in e{sup +}e{sup {minus}}{r_arrow}q{bar q}{gamma} events, {l_angle}n{sub quark}{sup {plus_minus}}{r_angle}. We find R{sub chrg}{equivalent_to}{l_angle}n{sub gluon}{sup {plus_minus}}{r_angle}/{l_angle}n{sub quark}{sup {plus_minus}}{r_angle}=1.04 {plus_minus}0.02(stat){plus_minus}0.05(syst) for jet-jet masses less than 7 GeV. {copyright} {ital 1997} {ital The American Physical Society}

Time arrow is influenced by the dark energy.

Science.gov (United States)

Allahverdyan, A E; Gurzadyan, V G

2016-05-01

The arrow of time and the accelerated expansion are two fundamental empirical facts of the universe. We advance the viewpoint that the dark energy (positive cosmological constant) accelerating the expansion of the universe also supports the time asymmetry. It is related to the decay of metastable states under generic perturbations, as we show on example of a microcanonical ensemble. These states will not be metastable without dark energy. The latter also ensures a hyperbolic motion leading to dynamic entropy production with the rate determined by the cosmological constant.

La génesis de la Economía de la Salud en Kenneth Arrow (1963

Directory of Open Access Journals (Sweden)

Jairo Restrepo

2016-01-01

Full Text Available Kenneth J. Arrow es uno de los economistas más destacados del siglo XX. Sus preocupaciones sobre el equilibrio competitivo y la optimalidad bajo condiciones de incertidumbre lo llevaron a publicar en 1963 el artículo “Uncertainty and the welfare economics of medical care”, reconocido como la génesis de la Economía de la Salud. En este ensayo se rinde un homenaje a esta obra, develando el plan intelectual para el análisis de bienestar de las prestaciones médicas, discutiendo la vigencia de los planteamientos originales y destacando sus principales implicaciones en cuanto a los temas objeto de análisis y discusión. La tesis central de Arrow sobre la imposibilidad del mercado para alcanzar una asignación eficiente sigue vigente debido, especialmente, a la incertidumbre respecto a la incidencia de enfermedades. Además del debate sobre Estado-mercado, a partir de Arrow se discuten las implicaciones de asuntos como la información asimétrica, el riesgo moral y las normas sociales.

Measurements of the decays {tau}{sup {minus}}{r_arrow}{ital h}{sup {minus}}{ital h}{sup +}{ital h}{sup {minus}}{nu}{sub {tau}} and {tau}{sup {minus}}{r_arrow}{ital h}{sup {minus}}{ital h}{sup +}{ital h}{sup {minus}}{pi}{sup 0}{nu}{sub {tau}}

Energy Technology Data Exchange (ETDEWEB)

Balest, R.; Cho, K.; Ford, W.T.; Lohner, M.; Park, H.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berger, B.E.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Dickson, M.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Elia, R.; Gaidarev, P.; Garcia-Sciveres, M.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Lee, T.; Liu, Y.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Soffer, A.; Avery, P.; Freyberger, A.; Lingel, K.; Prescott, C.; Rodriguez, J.; Yang, S.; Yelton, J.; Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; (CLEO Colla...

1995-11-20

We use a data sample of 2.8{times}10{sup 6} produced {tau}-pair events, obtained with the CLEO II detector, to measure {ital B}{bold (}{tau}{sup {minus}}{r_arrow}{ital h}{sup {minus}}{ital h}{sup +}{ital h}{sup {minus}}({pi}{sup 0}){nu}{sub {tau}}{bold )}, where {ital h} refers to either a charged {pi} or {ital K}. These branching fractions are measured with samples of lepton-tagged and 3 vs 3 events. We find {ital B}({tau}{sup {minus}}{r_arrow}{ital h}{sup {minus}}{ital h}{sup +}{ital h}{sup {minus}}{nu}{sub {tau}})=0.0951{plus_minus}0.0007 m*0.0020 and {ital B}({tau}{sup {minus}}{r_arrow}{ital h}{sup {minus}}{ital h}{sup +}{ital h}{sup {minus}}{pi}{sup 0}{nu}{sub {tau}})=0.0423{plus_minus} .0006{plus_minus}0.0022. We also measure {ital B}({tau}{sup {minus}}{r_arrow}{omega}{ital h}{sup {minus}}{nu}{sub {tau}})=0.0195{plus_minus}0.0007{plus_minus}0.0011 {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

First Observation of the Cabibbo Suppressed Decay {ital B}{sup {ital +}}{ital {r_arrow} {bar {ital D}}}{sup {ital 0}}{ital K}{sup +}

Energy Technology Data Exchange (ETDEWEB)

Athanas, M.; Avery, P.; Jones, C.D.; Lohner, M.; Patton, S.; Prescott, C.; Yelton, J.; Zheng, J. [University of Florida, Gainesville, Florida 32611 (United States); Brandenburg, G.; Briere, R.A.; Ershov, A.; Gao, Y.S.; Kim, D.Y.; Wilson, R.; Yamamoto, H. [Harvard University, Cambridge, Massachusetts 02138 (United States); Browder, T.E.; Li, Y.; Rodriguez, J.L. [University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Urbana-Champaign, Illinois 61801 (United States); Edwards, K.W. [Carleton University, Ottawa, Ontario, Canada K1S 5B6 and the Institute of Particle Physics (Canada); Bellerive, A.; Janicek, R.; MacFarlane, D.B.; Patel, P.M. [McGill University, Montreal, Quebec, Canada H3A 2T8 and the Institute of Particle Physics (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Kotov, S.; Kravchenko, I.; Kwak, N.; Zhou, L. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lee, S.J.; ONeill, J.J.; Poling, R.; Riehle, T.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wolf, A.; Zoeller, M.M. [The Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Severini, H.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; and others

1998-06-01

We have observed the decay B{sup +}{r_arrow}{bar D}{sup 0} K{sup +} , using 3.3{times}10{sup 6} B{bar B} pairs collected with the CLEO II detector at the Cornell Electron Storage Ring. We find the ratio of branching fractions R{equivalent_to}B(B{sup +}{r_arrow}{bar D}{sup 0}K{sup +})/B(B{sup +}{r_arrow}{bar D}{sup 0}{pi}{sup +})=0.055{plus_minus}0.014{plus_minus}0.005 . {copyright} {ital 1998} {ital The American Physical Society}

Arrow physicians: are economics and medicine philosophically incompatible?

Science.gov (United States)

Tsang, Sandro

2015-06-01

Economics is en route to its further expansion in medicine, but many in the medical community remain unconvinced that its impact will be positive. Thus, a philosophical enquiry into the compatibility of economics and medicine is necessary to resolve the disagreements. The fundamental mission of medicine obliges physicians to practise science and compassion to serve the patient's best interests. Conventional (neoclassical) economics assumes that individuals are self-interested and that competitive markets will emerge optimal states. Economics is seemingly incompatible with the emphasis of putting patients' interests first. This idea is refuted by Professor Kenneth Arrow's health economics seminal paper. Arrow emphasizes that medical practice involves agency, knowledge, trust and professionalism, and physician-patient relation critically affects care quality. The term Arrow Physician is used to mean a humanistic carer who has a concern for the patient and acts on the best available evidence with health equity in mind. To make this practice sustainable, implementing appropriate motivations, constitutions and institutions to enable altruistic agency is critical. There is substantial evidence that polycentric governance can encourage building trust and reciprocity, so as to avoid depletion of communal resources. This paper proposes building trusting institutions through granting altruistic physicians adequate autonomy to direct resources based on patients' technical needs. It also summarizes the philosophy bases of medicine and economics. It, therefore, contributes to developing a shared language to facilitate intellectual dialogues, and will encourage trans-disciplinary research into medical practice. This should lead to medicine being reoriented to care for whole persons again. © 2015 John Wiley & Sons, Ltd.

Control of Eospalax baileyi (Plateau Zokor) with arrow traps in western China

NARCIS (Netherlands)

Kong, Yang; Xidong, Li; Gaowei, Xu; Wei, Liu; Meerburg, B.G.

2016-01-01

In order to manage Eospalax (Myospalax) baileyi (Plateau zokors) pests with physical method, the efficacy of four different arrow traps was tested to control the plateau zokor in Sichuan Northwest Prairie, China. Population densities of 39.7-42.1 ha-1 were found in the test plots. Such densities

Form factors of the transitions {gamma}{sup *}{pi}{sup 0} {r_arrow} {gamma} and {gamma}{sup *}{eta}{r_arrow}{gamma}

Energy Technology Data Exchange (ETDEWEB)

Afanasev, A. [Continuous Electron Beam Accelerator Facility, Newport News, VA (United States)

1994-04-01

The author discusses possibilities to study {gamma}*{pi}{sup 0} and {gamma}*{eta} {r_arrow} {gamma} transition form factors at CEBAF energies. The author shows that for 4 GeV electron beam, these form factors can be measured at CEBAF for the 4-momentum transfers Q{sup 2} {le} 2.5 (GeV/c){sup 2} using virtual Compton scattering on the proton and nuclear target in the kinematic regime of low momentum transfers to the target. These measurements can be extended to Q{sup 2} {le} 4.0 (GeV/c){sup 2} using the electron beam with the energy 6 GeV.

Language of Mechanisms: Exam Analysis Reveals Students' Strengths, Strategies, and Errors When Using the Electron-Pushing Formalism (Curved Arrows) in New Reactions

Science.gov (United States)

Flynn, Alison B.; Featherstone, Ryan B.

2017-01-01

This study investigated students' successes, strategies, and common errors in their answers to questions that involved the electron-pushing (curved arrow) formalism (EPF), part of organic chemistry's language. We analyzed students' answers to two question types on midterms and final exams: (1) draw the electron-pushing arrows of a reaction step,…

The physics of time and the arrow thereof

Science.gov (United States)

Hecht, Eugene

2018-01-01

Although the physics of time is of fundamental importance, the concept gets little attention in most introductory courses. Still, we now know enough to begin to formulate a coherent account of the physical nature of time. Newton’s absolute time has given way to Leibniz’s relational time. From Relativity Theory we learn that time in addition to being relational is also relative, and local; as we will see, the rates at which events unfold are influenced by both the relative velocity of the observer, and the local gravitational field strength—time is not universal. The intrinsic relationship between light-speed and time will be examined via relativity. Moreover, it will be shown that the Special Theory requires that the quanta of the electromagnetic field (i.e. photons), only exist at speed c; the ramifications of that extraordinary property, coupled with conservation of energy, profoundly influence the progression of time. Time in our everyday lives is the abstract measure of the unfolding of macroscopic occurrences, all of which are irreversible. It is posited that these events are irreversible because they are invariably accompanied by the emission of radiant energy, photons and/or gravitons. By contrast, entropy is a descriptor of processes, it is not a causative agency; although correlated with the so-called arrow-of-time, it cannot be its cause. Using a variety of physical thought experiments, it will be shown that the unidirectional ‘flow’ of time, the arrow-of-time, is a result of the fact that energy quanta only travel toward the future. That is the fundamental asymmetry in our otherwise temporally symmetric physics.

Observation of the isospin-violating decay {ital D}{sub {ital s}}{sup *+}{r_arrow}{ital D}{sup +}{sub {ital s}}{pi}{sup 0}

Energy Technology Data Exchange (ETDEWEB)

Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Roberts, D.; Ryd, A.; Tajima, H.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Lohner, M.; Park, H.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berger, B.E.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Dickson, M.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Elia, R.; Gaidarev, P.; Garcia-Sciveres, M.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Lee, T.; Liu, Y.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Soffer, A.; Avery, P.; Freyberger, A.; Lingel, K.; Prescott, C.; Rodriguez, J.; Yang, S.; Yelton, J.; Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.; (CLEO Co...

1995-10-30

Using data collected with the CLEO II detector, we have observed the isospin-violating decay {ital D}{sub {ital s}}{sup *+}{r_arrow}{ital D}{sup +}{sub {ital s}}{pi}{sup 0}. The decay rate for this mode, relative to the dominant radiative decay, is found to be {Gamma}({ital D}{sub {ital s}}{sup *+}{r_arrow}{ital D}{sup +}{sub {ital s}}{pi}{sup 0}) /{Gamma}({ital D}{sub {ital s}}{sup *+}{r_arrow}{ital D}{sup +}{ital s}{gamma}) =0.062{sub {minus}0.018}{sup +0.020}{plus_minus}0.022. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

Is the pull-out force of the Meniscus Arrow in bone affected by the inward curling of the barbs during biodegradation? An in vitro study

NARCIS (Netherlands)

Wouters, Diederick B.; Burgerhof, Johannes G. M.; de Hosson, Jeff T. M.; Bos, Rudolf R. M.

Background: Inward curling of the barbs of Meniscus Arrows during degradation was observed in a previous study, in which swelling, distention, and water uptake by Meniscus Arrows was evaluated. This change of configuration could have consequences with respect to anchorage capacity in bone.

Early Twentieth Century Arrow, Javelin, and Dart Games of the Western Native American.

Science.gov (United States)

Pesavento, Wilma J.

The general purpose of this study was to determine whether the traditional native American ball games continued to be positive culture traits of the American Indian in the early twentieth century. The investigation was centered about (1) determining the current arrow, javelin, and dart games of western native Americans, (2) determining the…

Is the pull-out force of the Meniscus Arrow in bone affected by the inward curling of the barbs during biodegradation? An in vitro study.

Science.gov (United States)

Wouters, Diederick B; Burgerhof, Johannes G M; de Hosson, Jeff T M; Bos, Rudolf R M

2009-04-01

Inward curling of the barbs of Meniscus Arrows during degradation was observed in a previous study, in which swelling, distention, and water uptake by Meniscus Arrows was evaluated. This change of configuration could have consequences with respect to anchorage capacity in bone. Eight non-degraded Meniscus Arrows in the original configuration were pulled out of thawed, fresh-frozen human femoral condyle, and pull-out force was measured and compared with that of 6 Meniscus Arrows after 31 days of degradation under controlled conditions. No significant difference was found between the 2 groups with respect to the required pull-out force (t test), the distribution of the data, or the interaction between degradation and location, as evaluated by Mann-Whitney test, and no significant difference was found between the 2 groups with respect to the degradation state or position in the condyles, as evaluated by 2-way analysis of variance. Our results indicate that the decrease in barb-barb diameter during the first month of degradation of the Meniscus Arrows has no significant effect on the tensile pull-out force required for removal from human femur condyle. Further research should be undertaken to examine whether the same is true for other biodegradable devices with barbs.

Observation of {ital B}{sup +}{r_arrow}{ital {omega}K}{sup +} and Search for Related {ital B} Decays Modes

Energy Technology Data Exchange (ETDEWEB)

Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Urbana-Champaign, Illinois 61801 (United States); Edwards, K.W.; Edwards, K.W. [Institute of Particle Physics (Canada); Bellerive, A.; Bellerive, A.; Janicek, R.; Janicek, R.; MacFarlane, D.B.; MacFarlane, D.B.; Patel, P.M.; Patel, P.M. [Institute of Particle Physics (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Kotov, S.; Kravchenko, I.; Kwak, N.; Zhou, L. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lee, S.J.; ONeill, J.J.; Poling, R.; Riehle, T.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Severini, H.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Glenn, S.; Kwon, Y.; Lyon, A.L.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Savinov, V.; Ugolini, D.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; and others

1998-07-01

We have searched for two-body charmless decays of B mesons to purely hadronic exclusive final states including {omega} or {phi} mesons using data collected with the CLEO II detector. With this sample of 6.6{times}10{sup 6} B mesons we observe a signal for the {omega}K{sup +} final state, and measure a branching fraction of B(B{sup +}{r_arrow}{omega}K{sup +}) =(1.5{sup +0.7}{sub {minus}0.6}{plus_minus}0.2){times} 10{sup {minus}5} . We also observe some evidence for the {phi}K{sup {asterisk}} final state, and upper limits are given for 22 other decay modes. These results provide the opportunity for studies of theoretical models and physical parameters. {copyright} {ital 1998} {ital The American Physical Society}

Polarization of cumulative protons in the reaction. gamma. A r arrow pX

Energy Technology Data Exchange (ETDEWEB)

Avakyan, R.O.; Avetisyan, A.E.; Arestakesyan, G.A.; Bartikyan, M.V.; Garibyan, Y.A.; Grigoryan, A.E.; Eganov, V.S.; Karapetyan, A.P.; Karapetyan, M.P.; Keropyan, I.A.; and others

1989-02-01

The polarization of cumulative protons has been measured in the reaction {gamma}{ital A}{r arrow}{ital pX} in the proton-energy region 170--270 MeV for C and Sn nuclei in bremsstrahlung beams produced by 4.5- and 1.5-GeV electrons. The measured polarization value is close to zero.

Non-intentional but not automatic: reduction of word- and arrow-based compatibility effects by sound distractors in the same categorical domain.

Science.gov (United States)

Miles, James D; Proctor, Robert W

2009-10-01

In the current study, we show that the non-intentional processing of visually presented words and symbols can be attenuated by sounds. Importantly, this attenuation is dependent on the similarity in categorical domain between the sounds and words or symbols. Participants performed a task in which left or right responses were made contingent on the color of a centrally presented target that was either a location word (LEFT or RIGHT) or a left or right arrow. Responses were faster when they were on the side congruent with the word or arrow. This bias was reduced for location words by a neutral spoken word and for arrows by a tone series, but not vice versa. We suggest that words and symbols are processed with minimal attentional requirements until they are categorized into specific knowledge domains, but then become sensitive to other information within the same domain regardless of the similarity between modalities.

Javelin, Arrow, Dart and Pin Games of Native American Women of the Plains.

Science.gov (United States)

Pesavento, Wilma J.; Pesavento, Lisa C.

This study was designed to determine (1) the arrow, dart, javelin, and pin games of Native American girls and women of the Great Plains, (2) the geographical spread of the games within the culture area, and (3) the characteristics of the various games. Data for this investigation were researched from "Annual Reports of the Bureau of American…

Arrows as anchors: An analysis of the material features of electric field vector arrows

Science.gov (United States)

Gire, Elizabeth; Price, Edward

2014-12-01

Representations in physics possess both physical and conceptual aspects that are fundamentally intertwined and can interact to support or hinder sense making and computation. We use distributed cognition and the theory of conceptual blending with material anchors to interpret the roles of conceptual and material features of representations in students' use of representations for computation. We focus on the vector-arrows representation of electric fields and describe this representation as a conceptual blend of electric field concepts, physical space, and the material features of the representation (i.e., the physical writing and the surface upon which it is drawn). In this representation, spatial extent (e.g., distance on paper) is used to represent both distances in coordinate space and magnitudes of electric field vectors. In conceptual blending theory, this conflation is described as a clash between the input spaces in the blend. We explore the benefits and drawbacks of this clash, as well as other features of this representation. This analysis is illustrated with examples from clinical problem-solving interviews with upper-division physics majors. We see that while these intermediate physics students make a variety of errors using this representation, they also use the geometric features of the representation to add electric field contributions and to organize the problem situation productively.

Arrows as anchors: An analysis of the material features of electric field vector arrows

Directory of Open Access Journals (Sweden)

Elizabeth Gire

2014-08-01

Full Text Available Representations in physics possess both physical and conceptual aspects that are fundamentally intertwined and can interact to support or hinder sense making and computation. We use distributed cognition and the theory of conceptual blending with material anchors to interpret the roles of conceptual and material features of representations in students’ use of representations for computation. We focus on the vector-arrows representation of electric fields and describe this representation as a conceptual blend of electric field concepts, physical space, and the material features of the representation (i.e., the physical writing and the surface upon which it is drawn. In this representation, spatial extent (e.g., distance on paper is used to represent both distances in coordinate space and magnitudes of electric field vectors. In conceptual blending theory, this conflation is described as a clash between the input spaces in the blend. We explore the benefits and drawbacks of this clash, as well as other features of this representation. This analysis is illustrated with examples from clinical problem-solving interviews with upper-division physics majors. We see that while these intermediate physics students make a variety of errors using this representation, they also use the geometric features of the representation to add electric field contributions and to organize the problem situation productively.

26 CFR 48.4161(b)-1 - Imposition and rates of tax; bows and arrows.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Imposition and rates of tax; bows and arrows. 48.4161(b)-1 Section 48.4161(b)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) MISCELLANEOUS EXCISE TAXES MANUFACTURERS AND RETAILERS EXCISE TAXES Sporting Goods § 48.4161(b)-1...

Six Impossible Mechanisms before Breakfast: Arrow Pushing as an Instructional Device in Inorganic Chemistry

Science.gov (United States)

Berg, Steffen; Ghosh, Abhik

2013-01-01

In a recent article by the authors, the suggestion was made that arrow pushing, a widely used tool in organic chemistry, could also be profitably employed in the teaching of introductory inorganic chemistry. A number of relatively simple reactions were used to illustrate this thesis, raising the question whether the same approach might rationalize…

The emergence of time's arrows and special science laws from physics

OpenAIRE

Loewer, Barry

2011-01-01

In this paper, I will argue that there is an important connection between two questions concerning how certain features of the macro world emerge from the laws and processes of fundamental microphysics and suggest an approach to answering these questions. The approach involves a kind of emergence but quite different from ‘top-down’ emergence discussed at the conference, for which an earlier version of this paper was written. The two questions are (i) How do ‘the arrows of time’ emerge from mi...

Social Conflicts in Arrow Of God: Lessons in Flexibility and Good Governance

Directory of Open Access Journals (Sweden)

Anaso George Nworah

2016-01-01

Full Text Available Chinua Achebe’s second novel, Arrow of God, is concerned with the theme of conflict. According to Holman C. Hugh (1960, there are four basic levels of conflict: struggle between the protagonist and the antagonist, the protagonist with the society, struggle in the mind of the protagonist or the protagonist struggling with fate, destiny or force of nature. Conflicts in Arrow of God delineate three of these struggles in a concentration of events leading to the destruction of the social order in the community (Umuaro. However, the conflicts are linked with colonialism which is at the root of the conflict. In this view, the novel is to some extent, a protest against colonialism and the suffering that it brought to the colonised people generally and the Igbo specifically. Arising from the above, this paper draws some implications from the actions of the protagonist to reveal the connection between a leader’s flexibility and good governance as reflected in the life of the old chief priest (Ezeulu. The novel made its debut in 1964, symbolically marking a year since Nigeria’s adoption of Republican Constitution. The connection between Umuaro’s institution of Ulu and its priest as source of law and order with Nigeria’s adoption of the republican constitution is made obvious in this study. Through this, the nexus between literature and reality is thus reinforced. Keywords: Colonialism, Conflict, Myth, Protest, Governance, Republicanism

The Geohistorical Time Arrow: From Steno's Stratigraphic Principles to Boltzmann's Past Hypothesis

Science.gov (United States)

Kravitz, Gadi

2014-01-01

Geologists have always embraced the time arrow in order to reconstruct the past geology of Earth, thus turning geology into a historical science. The covert assumption regarding the direction of time from past to present appears in Nicolas Steno's principles of stratigraphy. The intuitive-metaphysical nature of Steno's assumption was based on a…

The arthroscopic treatment of displaced tibial spine fractures in children and adolescents using Meniscus Arrows(A (R))

NARCIS (Netherlands)

Wouters, Diederick B.; de Graaf, Joost S.; Hemmer, Patrick H.; Burgerhof, Johannes G. M.; Kramer, William L. M.

This article summarises the results of a newly developed technique that utilises Meniscus Arrows(A (R)) for the arthroscopic fixation of displaced tibial spine fractures in children and adolescents. Twelve tibial spine fractures in the knees of eleven children between 6 and 15 years old, with an

The emergence of time's arrows and special science laws from physics.

Science.gov (United States)

Loewer, Barry

2012-02-06

In this paper, I will argue that there is an important connection between two questions concerning how certain features of the macro world emerge from the laws and processes of fundamental microphysics and suggest an approach to answering these questions. The approach involves a kind of emergence but quite different from 'top-down' emergence discussed at the conference, for which an earlier version of this paper was written. The two questions are (i) How do 'the arrows of time' emerge from microphysics? (ii) How do macroscopic special science laws and causation emerge from microphysics? Answering these questions is especially urgent for those, who like myself, think that a certain version of physicalism, which I call 'micro-physical completeness' (MC), is true. According to MC, there are fundamental dynamical laws that completely govern (deterministically or probabilistically), the evolution of all micro-physical events and there are no additional ontologically independent dynamical or causal special science laws. In other words, there is no ontologically independent 'top-down' causation. Of course, MC does not imply that physicists now or ever will know or propose the complete laws of physics. Or even if the complete laws were known we would know how special science properties and laws reduce to laws and properties of fundamental physics. Rather, MC is a contingent metaphysical claim about the laws of our world. After a discussion of the two questions, I will argue the key to showing how it is possible for the arrows of time and the special science laws to emerge from microphysics and a certain account of how thermodynamics is related to fundamental dynamical laws.

Is the hypothesis about a low entropy initial state of the Universe necessary for explaining the arrow of time?

Science.gov (United States)

Goldstein, Sheldon; Tumulka, Roderich; Zanghı, Nino

2016-07-01

According to statistical mechanics, microstates of an isolated physical system (say, a gas in a box) at time t0 in a given macrostate of less-than-maximal entropy typically evolve in such a way that the entropy at time t increases with |t -t0| in both time directions. In order to account for the observed entropy increase in only one time direction, the thermodynamic arrow of time, one usually appeals to the hypothesis that the initial state of the Universe was one of very low entropy. In certain recent models of cosmology, however, no hypothesis about the initial state of the Universe is invoked. We discuss how the emergence of a thermodynamic arrow of time in such models can nevertheless be compatible with the above-mentioned consequence of statistical mechanics, appearances to the contrary notwithstanding.

Wnt Signaling Is Required for Long-Term Memory Formation

Directory of Open Access Journals (Sweden)

Ying Tan

2013-09-01

Full Text Available Wnt signaling regulates synaptic plasticity and neurogenesis in the adult nervous system, suggesting a potential role in behavioral processes. Here, we probed the requirement for Wnt signaling during olfactory memory formation in Drosophila using an inducible RNAi approach. Interfering with β-catenin expression in adult mushroom body neurons specifically impaired long-term memory (LTM without altering short-term memory. The impairment was reversible, being rescued by expression of a wild-type β-catenin transgene, and correlated with disruption of a cellular LTM trace. Inhibition of wingless, a Wnt ligand, and arrow, a Wnt coreceptor, also impaired LTM. Wingless expression in wild-type flies was transiently elevated in the brain after LTM conditioning. Thus, inhibiting three key components of the Wnt signaling pathway in adult mushroom bodies impairs LTM, indicating that this pathway mechanistically underlies this specific form of memory.

Na(3p left-arrow 3s) excitation by impact of slow multiply charged ions

International Nuclear Information System (INIS)

Horvath, G.; Schweinzer, J.; Winter, H.; Aumayr, F.

1996-01-01

We present a systematic experimental and theoretical study of Na(3p left-arrow 3s) excitation by slow (v NaI with projectile ion charge state q is investigated. Due to the dominance of the competing electron capture channels at low collision energies E, the excitation cross sections deviate significantly from a commonly applied σ/q=f(E/q) cross-section scaling relation. copyright 1996 The American Physical Society

‘An augury of the world’s ruin’ and the making of the tragic hero in Chinua Achebe’s Arrow of God

Directory of Open Access Journals (Sweden)

Ignatius Chukwumah

2016-06-01

Full Text Available Chinua Achebe’s Arrow of God has been adjudged by critics as a tragic work with Ezeulu as its tragic hero. However, none of these studies has paid detailed attention to the framing of Ezeulu in the historical context of his age. How he appears when compared to a classical Greek tragic hero has also been ignored. A major context giving rise to Ezeulu becoming a tragic hero is the period leading to the synthesis of two contrary histories, juxtaposed discourses and the collision of opposites and contraries in the sociocultural and political sphere of the villages of Umuaro and Okperi. This circumstance is captured by the narrator as ‘an augury of the world’s ruin’, by Nwaka as ‘the white man turned us upside down’ and by Ezeulu as ‘the world is spoilt and there is no longer head or tail in anything that is done’. Allen, an earlier District Commissioner in Things Fall Apart, but textually implicated in Arrow of God, terms it ‘great situations’. The above historical context requires more than mastery and acknowledgement by the tragic figure, in the absence of which he, a self-professed knowledgeable person, becomes a victim of what he failed to take into account. Consequently, he is set aside as a specimen for history and other men. This article will use Hegel’s and Aristotle’s theories of history and of tragedy, respectively, to explicate the above. It concludes that the tragic hero of Chinua Achebe’s Arrow of God is substantially the victim of the clash between Umuaro’s history and Hegel’s History. ’n Teken van die wêreld se ondergang en die skepping van die tragiese held in Chinua Achebe se Arrow of God. Chinua Achebe se boek, Arrow of God, word deur kritici beskryf as ’n tragedie met die karakter Ezeulu as held. Niemand het egter noukeurige aandag geskenk aan hoe Ezeulu inpas in die gapings van botsende geskiedenisse soos vergestalt in die mens ten opsigte van hulle optredes, houdings, vrese en begeertes nie

Final evaluation report for Lockheed Idaho Technologies Company, ARROW-PAK packaging, Docket 95-40-7A, Type A container

International Nuclear Information System (INIS)

Kelly, D.L.

1995-11-01

The report documents the U.S. Department of Transportation Specification 7A Type A (DOT-7A) compliance test results of the ARROW-PAK packaging. The ARROW-PAK packaging system consists of Marlex M-8000 Driscopipe (Series 8000 [gas] or Series 8600 [industrial]) resin pipe, manufactured by Phillips-Driscopipe, Inc., and is sealed with two dome-shaped end caps manufactured from the same materials. The patented sealing process involves the use of electrical energy to heat opposing faces of the pipe and end caps, and hydraulic rams to press the heated surfaces together. This fusion process produces a homogeneous bonding of the end cap to the pipe. The packaging may be used with or without the two internal plywood spacers. This packaging was evaluated and tested in October 1995. The packaging configuration described in this report is designed to ship Type A quantities of solid radioactive materials, Form No. 1, Form No. 2, and Form No. 3

Cosmic update dark puzzles : arrow of time : future history

CERN Document Server

Adams, Fred; Mersini-Houghton, Laura; Nekoogar, Farzad

2012-01-01

"...The Multiversal book series is equally unique, providing book-length extensions of the lectures with enough additional depth for those who truly want to explore these fields, while also providing the kind of clarity that is appropriate for interested lay people to grasp the general principles involved." - Lawrence M. Krauss Cosmic Update covers: A novel approach to uncover the dark faces of the Standard Model of cosmology. The possibility that Dark Energy and Dark Matter are manifestations of the inhomogeneous geometry of our Universe. The history of cosmological model building and the general architecture of cosmological models. Illustrations of the Large Scale Structure of the Universe. A new perspective on the classical static Einstein Cosmos. Global properties of World Models including their Topology. The Arrow of Time in a Universe with a Positive Cosmological Constant. The exploration of the consequences of a fundamental Cosmological Constant for our Universe. The exploration of why the current ob...

Field measurements of biogenic volatile organic compounds in the atmosphere using solid-phase microextraction Arrow

Science.gov (United States)

Feijó Barreira, Luís Miguel; Duporté, Geoffroy; Rönkkö, Tuukka; Parshintsev, Jevgeni; Hartonen, Kari; Hyrsky, Lydia; Heikkinen, Enna; Jussila, Matti; Kulmala, Markku; Riekkola, Marja-Liisa

2018-02-01

Biogenic volatile organic compounds (BVOCs) emitted by terrestrial vegetation participate in a diversity of natural processes. These compounds impact both short-range processes, such as on plant protection and communication, and long-range processes, for example by participating in aerosol particle formation and growth. The biodiversity of plant species around the Earth, the vast assortment of emitted BVOCs, and their trace atmospheric concentrations contribute to the substantial remaining uncertainties about the effects of these compounds on atmospheric chemistry and physics, and call for the development of novel collection devices that can offer portability with improved selectivity and capacity. In this study, a novel solid-phase microextraction (SPME) Arrow sampling system was used for the static and dynamic collection of BVOCs from a boreal forest, and samples were subsequently analyzed on site by gas chromatography-mass spectrometry (GC-MS). This system offers higher sampling capacity and improved robustness when compared to traditional equilibrium-based SPME techniques, such as SPME fibers. Field measurements were performed in summer 2017 at the Station for Measuring Ecosystem-Atmosphere Relations (SMEAR II) in Hyytiälä, Finland. Complementary laboratory tests were also performed to compare the SPME-based techniques under controlled experimental conditions and to evaluate the effect of temperature and relative humidity on their extraction performance. The most abundant monoterpenes and aldehydes were successfully collected. A significant improvement on sampling capacity was observed with the new SPME Arrow system over SPME fibers, with collected amounts being approximately 2 × higher for monoterpenes and 7-8 × higher for aldehydes. BVOC species exhibited different affinities for the type of sorbent materials used (polydimethylsiloxane (PDMS)-carbon wide range (WR) vs. PDMS-divinylbenzene (DVB)). Higher extraction efficiencies were obtained with dynamic

Test and evaluation report for Lockheed Idaho Technologies Company, arrow-pak packaging, docket 95-40-7A, type A container

International Nuclear Information System (INIS)

Kelly, D.L.

1996-01-01

This report incorporates the U.S. Department of Energy, Office of Facility Safety Analysis (DOE/EH-32) approval letter for packaging use. This report documents the U.S. Department of Transportation Specification 7A Type A (DOT-7A) compliance test results of the Arrow-Pak packaging. The Arrow-Pak packaging system consists of Marlex M-8000 Driscopipe, manufactured by Phillips-Driscopipe, Inc., and is sealed with two dome-shaped end caps manufactured from the same materials. The patented sealing process involves the use of electrical energy to heat opposing faces of the pipe and end caps, and hydraulic rams to press the heated surfaces together. This fusion process produces a homogeneous bonding of the end cap to the pipe. The packaging may be used with or without the two internal plywood spacers. This packaging configuration described in this report is designed to ship Type A quantities of solid radioactive materials

Registro de Cyclocephala flavipennis Arrow, 1914 (Coleoptera: Melolonthidae danificando plantas de mirtileiro no Brasil

Directory of Open Access Journals (Sweden)

Gabriela Inés Diez-Rodríguez

2015-02-01

Full Text Available Larvas de Cyclocephala flavipennis Arrow, 1914, são comumente encontradas em cereais de inverno (trigo, cevada, aveia e triticale, milho e soja, no Rio Grande do Sul. Em março de 2012, larvas desta espécie foram detectadas em plantas de mirtileiro (Vaccinium ashei Reade, cultivar 'O´Neal', no município de Pelotas, RS. Os insetos alimentaram-se de raízes em áreas restritas do pomar. Este é o primeiro relato da ocorrência do coró-pequeno, C. flavipennis, em plantas de mirtileiro

Controlling Attention to Gaze and Arrows in Childhood: An fMRI Study of Typical Development and Autism Spectrum Disorders

Science.gov (United States)

Vaidya, Chandan J.; Foss-Feig, Jennifer; Shook, Devon; Kaplan, Lauren; Kenworthy, Lauren; Gaillard, William D.

2011-01-01

Functional magnetic resonance imaging was used to examine functional anatomy of attention to social (eye gaze) and nonsocial (arrow) communicative stimuli in late childhood and in a disorder defined by atypical processing of social stimuli, Autism Spectrum Disorders (ASD). Children responded to a target word ("LEFT"/"RIGHT") in the context of a…

posterior reversible encephalopathy syndrome (PRES)

African Journals Online (AJOL)

signal intensity located in the bilateral frontal lobes, parietal lobes, temporal lobes and occipital lobes. (arrows); B and C, T2WI and FLAIR sequence, respectively, both of which show hyperintense signals in the same positions indicated by arrows; D, DWI shows slightly increased signals in the frontal lobes and isointense ...

Observation of the weak time’s arrow in B mesons

CERN Multimedia

CERN. Geneva

2012-01-01

The mechanism of CP violation in weak interactions, as arising from the single physical phase in the CKM matrix, has been validated by more than a decade of intense experimental work probing CP violation, particularly with studies with B mesons. Since the Standard Model theory is CPT invariant, it predicts a “weak arrow of time” matching the large observed matter-antimatter asymmetry in B mesons. However, until recently there has been no direct observation of the expected, large time reversal (T) asymmetry. In this seminar we shall discuss how the BABAR experiment at SLAC has conducted a new data analysis where the decays of entangled neutral B mesons allow comparisons between the rates of four different transitions and their inverse, as a function of the time evolution of the B meson. The results lead to the first high significance, direct observation of T non-invariance through the exchange of initial and final states in transitions that can only be connected by a T symmetry transformation.

Arrow-wing supersonic cruise aircraft structural design concepts evaluation. Volume 3: Sections 12 through 14

Science.gov (United States)

Sakata, I. F.; Davis, G. W.

1975-01-01

The design of an economically viable supersonic cruise aircraft requires the lowest attainable structural-mass fraction commensurate with the selected near-term structural material technology. To achieve this goal of minimum structural-mass fraction, various combinations of promising wing and fuselage primary structure were analyzed for the load-temperature environment applicable to the arrow wing configuration. This analysis was conducted in accordance with the design criteria specified and included extensive use of computer-aided analytical methods to screen the candidate concepts and select the most promising concepts for the in-depth structural analysis.

Test Plan for Lockheed Idaho Technologies Company (LITCO), ARROW-PAK Packaging, Docket 95-40-7A, Type A Container

International Nuclear Information System (INIS)

Kelly, D.L.

1995-01-01

This report documents the U.S. Department of Transportation Specification 7A Type A (DOT-7A) compliance testing to be followed for qualification of the Lockheed Idaho Technologies Company, ARROW-PAK, for use as a Type A Packaging. The packaging configuration being tested is intended for transportation of radioactive solids, Form No. 1, Form No. 2, and Form No. 3

EL TEOREMA DE LA IMPOSIBILIDAD DE ARROW Y LA ELECCIÓN INTERDEPENDIENTE

Directory of Open Access Journals (Sweden)

Freddy Cante

2000-12-01

Full Text Available Si el problema de la elección social es planteado como un proceso de decisión interdependiente, admitiendo además la comparación interpersonal de las expectativas y estados del mundo de los ciudadanos, y asumiendo que la interacción social implica conflictos negociables y no negociables, es posible prever situaciones de consenso y convivencia social que serian inadmisibles en la rigidez axiomática y lógica del teorema de la imposibilidad de Arrow.I the problem of the social choice is characterized as a process of interdependent decision, also admitting the interpersonal comparison of the expectations and states of the world of citizens and assuming that the social interaction implies negotiable and not negotiable conflicts, it is possible to foresee consent situations and social

Arrow-wing supersonic cruise aircraft structural design concepts evaluation. Volume 4: Sections 15 through 21

Science.gov (United States)

Sakata, I. F.; Davis, G. W.

1975-01-01

The analyses performed to provide structural mass estimates for the arrow wing supersonic cruise aircraft are presented. To realize the full potential for structural mass reduction, a spectrum of approaches for the wing and fuselage primary structure design were investigated. The objective was: (1) to assess the relative merits of various structural arrangements, concepts, and materials; (2) to select the structural approach best suited for the Mach 2.7 environment; and (3) to provide construction details and structural mass estimates based on in-depth structural design studies. Production costs, propulsion-airframe integration, and advanced technology assessment are included.

DNA → RNA: What Do Students Think the Arrow Means?

Science.gov (United States)

Fisk, J. Nick; Newman, Dina L.

2014-01-01

The central dogma of molecular biology, a model that has remained intact for decades, describes the transfer of genetic information from DNA to protein though an RNA intermediate. While recent work has illustrated many exceptions to the central dogma, it is still a common model used to describe and study the relationship between genes and protein products. We investigated understanding of central dogma concepts and found that students are not primed to think about information when presented with the canonical figure of the central dogma. We also uncovered conceptual errors in student interpretation of the meaning of the transcription arrow in the central dogma representation; 36% of students (n = 128; all undergraduate levels) described transcription as a chemical conversion of DNA into RNA or suggested that RNA existed before the process of transcription began. Interviews confirm that students with weak conceptual understanding of information flow find inappropriate meaning in the canonical representation of central dogma. Therefore, we suggest that use of this representation during instruction can be counterproductive unless educators are explicit about the underlying meaning. PMID:26086664

Preparation and characterisation of irradiated crab chitosan and New Zealand Arrow squid pen chitosan

International Nuclear Information System (INIS)

Shavandi, Amin; Bekhit, Adnan A.; Bekhit, Alaa El-Din A.; Sun, Zhifa; Ali, M. Azam

2015-01-01

The properties of chitosan from Arrow squid (Nototodarus sloanii) pen (CHS) and commercial crab shell (CHC) were investigated using FTIR, DSC, SEM and XRD before and after irradiation at the dose of 28 kGy in the presence or absence of 5% water. Also, the viscosity, deacetylation degree, water and oil holding capacities, colour and antimicrobial activities of the chitosan samples were determined. Irradiation decreased (P < 0.05) the viscosity of CHC from 0.21 to 0.03 Pa s and of CHS from 1.71 to 0.23 Pa s. The inclusion of water had no effect on the viscosity of irradiated chitosan. Irradiation did not affect the degree of deacetylation of CHC, but increased the deacetylation degree of CHS from 72.78 to 82.29% in samples with 5% water. Water and oil holding capacities of CHS (1197.30% and 873.3%, respectively) were higher (P < 0.05) than those found in CHC (340.70% and 264.40%, respectively). The water and oil holding capacities were decreased for both types of chitosan irradiation, but were not affected by the addition of water. Squid pen chitosan was whiter in colour (White Index = 90.06%) compared to CHC (White Index = 83.70%). Generally, the CHC samples (control and irradiated) exhibited better antibacterial activity compared to CHS, but the opposite was observed with antifungal activity. - Highlights: • Chitosan prepared from Arrow squid pens (Nototodarus sloanii). • Chitosan samples were gamma irradiated at 28 kGy. • Squid pen chitosan showed high fat and water uptake capacities compared to crab shell chitosan. • Gamma irradiation enhanced the DDA of squid pen chitosan but not crab shell chitosan.

Scan path entropy and Arrow plots: Capturing scanning behavior of multiple observers

Directory of Open Access Journals (Sweden)

Ignace T C Hooge

2013-12-01

Full Text Available Designers of visual communication material want their material to attract and retain attention. In marketing research, heat maps, dwell time, and time to AOI first hit are often used as evaluation parameters. Here we present two additional measures 1 scan path entropy to quantify gaze guidance and 2 the arrow plot to visualize the average scan path. Both are based on string representations of scan paths. The latter also incorporates transition matrices and time required for 50% of the observers to first hit AOIs (T50. The new measures were tested in an eye tracking study (48 observers, 39 advertisements. Scan path entropy is a sensible measure for gaze guidance and the new visualization method reveals aspects of the average scan path and gives a better indication in what order global scanning takes place.

VECTOR AND TENSOR ANALYZING POWERS IN THE PB-208(D)OVER-RIGHT-ARROW,T)PB-207 REACTION AT 200 AND 360 MEV

NARCIS (Netherlands)

VANDEWIELE, J; LANGEVINJOLIOT, H; GUILLOT, J; ROSIER, LH; WILLIS, A; MORLET, M; DUHAMELCHRETIEN, G; GERLIC, E; TOMASIGUSTAFSSON, E; BLASI, N; MICHELETTI, S; VANDERWERF, SY

Cross sections and vector and tensor analyzing powers for the main levels in Pb-207 have been measured via the Pb-208(d over arrow pointing right, t)Pb-207 reaction at 200 and 360 MeV incident energies. A(y) and A(yy) spin observables allow a clear identification of the valence levels, especially at

Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps. Tectonic and palaeographical implications

Energy Technology Data Exchange (ETDEWEB)

Gurk, M.; Schnegg, P.-A. [Universite' de Neuchatel, Groupe de Geomagnetisme, Institut de Geologie, Neuchatel (Switzerland)

2001-08-01

The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous) large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubuenden) probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT) and Geomagnetic Deep Sounding (GDS) station in the Alps of Graubuenden and Valais (Western Switzerland) indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Buendnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA) shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with the recent data from Switzerland, the following geological implications are discussed: i) a spatial decoupling of induction processes from the upper to the lower crust; ii) a lower crustal conductive structure caused by the identification of the Northern Adriatic promontory or terrane; iii) the eastward continuation of the Buendnerschiefer-facies at least to the tectonic window of Rechnitz.

Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps. Tectonic and palaeographical implications

International Nuclear Information System (INIS)

Gurk, M.; Schnegg, P.-A.

2001-01-01

The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous) large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubuenden) probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT) and Geomagnetic Deep Sounding (GDS) station in the Alps of Graubuenden and Valais (Western Switzerland) indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Buendnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA) shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with the recent data from Switzerland, the following geological implications are discussed: i) a spatial decoupling of induction processes from the upper to the lower crust; ii) a lower crustal conductive structure caused by the identification of the Northern Adriatic promontory or terrane; iii) the eastward continuation of the Buendnerschiefer-facies at least to the tectonic window of Rechnitz

SPIN DETERMINATION OF VALENCE AND INNER HOLE STATES VIA THE PB-208((D)OVER-RIGHT-ARROW,T)PB-207 REACTION AT ED=200 MEV

NARCIS (Netherlands)

LANGEVINJOLIOT, H; VANDEWIELE, J; GUILLOT, J; GERLIC, E; ROSIER, LH; WILLIS, A; MORLET, M; DUHAMELCHRETIEN, G; TOMASIGUSTAFSSON, E; BLASI, N; MICHELETTI, S; VANDERWERF, SY

Highly excited neutron hole states in Pb-207 have been studied via the (d, over arrow pointing right, t) reaction at E(d) = 200 MeV using for the first time a polarized beam, with both vector and tensor components. The determination of overlapping neutron hole response functions takes advantage of

Questioning the quark model. Strong interaction, gravitation and time arrows. An approach to asymptotic freedom

International Nuclear Information System (INIS)

Basini, G.

2003-01-01

Asymptotic freedom, as a natural result of a theory based on a general approach, derived by a new interpretation of phenomena like the EPR paradox, the black-hole formation and the absence of primary cosmic antimatter is presented. In this approach, conservation laws are considered always and absolutely valid, leading to the possibility of topology changes, and recovering the mutual influence between fundamental forces. Moreover, a new consideration of time arrows leads to asymptotic freedom as a necessary consequence. In fact, asymptotic freedom of strong interactions seems to be a feature common also to gravitational interaction, if induced-gravity theories (t → ∞) are taken into account and a symmetric-time dynamics is recovered in the light of a general conservation principle. (authors)

Questioning the quark model. Strong interaction, gravitation and time arrows. An approach to asymptotic freedom

Energy Technology Data Exchange (ETDEWEB)

Basini, G. [Istituto Nazionale di Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati; Capozziello, S. [E.R. Caianiello, Dipt. di Fisica, Roma (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Universita di Salerno, Boronissi, SA (Italy)

2003-09-01

Asymptotic freedom, as a natural result of a theory based on a general approach, derived by a new interpretation of phenomena like the EPR paradox, the black-hole formation and the absence of primary cosmic antimatter is presented. In this approach, conservation laws are considered always and absolutely valid, leading to the possibility of topology changes, and recovering the mutual influence between fundamental forces. Moreover, a new consideration of time arrows leads to asymptotic freedom as a necessary consequence. In fact, asymptotic freedom of strong interactions seems to be a feature common also to gravitational interaction, if induced-gravity theories (t {yields} {infinity}) are taken into account and a symmetric-time dynamics is recovered in the light of a general conservation principle. (authors)

Implementing Quality Criteria in Designing and Conducting a Sequential Quan [right arrow] Qual Mixed Methods Study of Student Engagement with Learning Applied Research Methods Online

Science.gov (United States)

Ivankova, Nataliya V.

2014-01-01

In spite of recent methodological developments related to quality assurance in mixed methods research, practical examples of how to implement quality criteria in designing and conducting sequential QUAN [right arrow] QUAL mixed methods studies to ensure the process is systematic and rigorous remain scarce. This article discusses a three-step…

Anomalous directional behaviour of the real parts of the induction arrows in the Eastern Alps: tectonic and palaeogeographic implications

Directory of Open Access Journals (Sweden)

P. A. Schnegg

2001-06-01

Full Text Available The electromagnetic induction pattern in the Eastern Alps is characterised by a (continuous large-scale zone on which the real parts of the induction arrows show anomalous directional behaviour. This zone extends from the Penninic Domain of Eastern Switzerland (Graubünden probably into the Carpathian ranges. A coarse mesh of a Magnetotelluric (MT and Geomagnetic Deep Sounding (GDS station in the Alps of Graubünden and Valais (Western Switzerland indicates that this electromagnetic anomaly is restricted to the Mesozoic sediments of the North Penninic Bündnerschiefer-facies that begins in Eastern Switzerland and extends towards the east beneath Austroalpine, South Penninic and Southalpine units. Striking similarities in position and arrangement between this zone and the magnetic signature in the Eastern Alps are found. The analysis of the GDS data with the method of the Hypothetical Event Analysis (HEA shows that current channelling affects the electromagnetic fields in this zone and causes the anomalous direction of induction arrows. Based on the combined interpretation of GDS data from the Eastern Alps and West Hungary together with our recent data from Switzerland, the following geological implications are discussed: i a spatial decoupling of induction processes from the upper to the lower crust; ii a lower crustal conductive structure caused by the indentation of the Northern Adriatic promontory or terrane; iii the eastward continuation of the Bündnerschiefer-facies at least to the tectonic window of Rechnitz.

Entanglement versus Stosszahlansatz: disappearance of the thermodynamic arrow in a high-correlation environment.

Science.gov (United States)

Partovi, M Hossein

2008-02-01

The crucial role of ambient correlations in determining thermodynamic behavior is established. A class of entangled states of two macroscopic systems is constructed such that each component is in a state of thermal equilibrium at a given temperature, and when the two are allowed to interact heat can flow from the colder to the hotter system. A dilute gas model exhibiting this behavior is presented. This reversal of the thermodynamic arrow is a consequence of the entanglement between the two systems, a condition that is opposite to molecular chaos and shown to be unlikely in a low-entropy environment. By contrast, the second law is established by proving Clausius' inequality in a low-entropy environment. These general results strongly support the expectation, first expressed by Boltzmann and subsequently elaborated by others, that the second law is an emergent phenomenon which requires a low-entropy cosmological environment, one that can effectively function as an ideal information sink.

On the synchronization of identical and non-identical 4-D chaotic systems using arrow form matrix

International Nuclear Information System (INIS)

Hammami, S.; Ben Saad, K.; Benrejeb, M.

2009-01-01

Using the Borne and Gentina practical criterion associated with the Benrejeb canonical arrow form matrix, to derive the stability property of dynamic complex systems, a new strategy of control is formulated for chaos synchronization of two identical Lorenz Stenflo systems and two new four-dimensional chaotic systems, namely the Qi chaotic systems. The designed controller ensures that the state variables of both controlled chaotic slave Lorenz Stenflo and Qi systems globally synchronizes with the state variables of the master systems, respectively. It is also shown that Qi system globally synchronizes with Lorenz Stenflo system under the afforded generalized strategy of control. Numerical simulations are carried out to assess the performance of the proposed contributions in the important field of chaotic synchronization.

Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration

Science.gov (United States)

Turner, M. J.; Grande, D. L.

1978-01-01

Based on estimated graphite and boron fiber properties, allowable stresses and strains were established for advanced composite materials. Stiffened panel and conventional sandwich panel concepts were designed and analyzed, using graphite/polyimide and boron/polyimide materials. The conventional sandwich panel was elected as the structural concept for the modified wing structure. Upper and lower surface panels of the arrow wing structure were then redesigned, using high strength graphite/polyimide sandwich panels, retaining the titanium spars and ribs from the prior study. The ATLAS integrated analysis and design system was used for stress analysis and automated resizing of surface panels. Flutter analysis of the hybrid structure showed a significant decrease in flutter speed relative to the titanium wing design. The flutter speed was increased to that of the titanium design by selective increase in laminate thickness and by using graphite fibers with properties intermediate between high strength and high modulus values.

Optimized-geometry ARROW waveguides using TiO{sub 2} as anti-resonant layer

Energy Technology Data Exchange (ETDEWEB)

Carvalho, Daniel O.; Albertin, Katia F.; Alayo, Marco I. [PSI, University of Sao Paulo (Brazil)

2010-04-15

The simulation, fabrication and characterization of ARROW waveguides using dielectric films deposited by Plasma Enhanced Chemical Vapor Deposition (PECVD) and Sputtering techniques, are presented in this work. Amorphous titanium oxide (TiO{sub 2}) films were used as first cladding layer and silicon oxynitride (SiO{sub x}N{sub y}) films, as core layer. Furthermore, homemade routines based in two computational methods were used, for numerical simulations: Transfer Matrix Method (TMM) for the determination of the optimum thickness values of the Fabry-Perot layers, and the Finite Difference Method (FDM) for 2D design and determination of the maximum width that allows single-mode operation. The utilization of thermally grown silicon oxide as second anti-resonant layer, along with improvements in the Reactive Ion Etching conditions for the definition of sidewalls of the optical waveguides were responsible for diminishing optical attenuations. Optimization of the waveguide rib height was done both through FDM simulations and experimentally. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

DNA → RNA: What Do Students Think the Arrow Means?

Science.gov (United States)

Wright, L Kate; Fisk, J Nick; Newman, Dina L

2014-01-01

The central dogma of molecular biology, a model that has remained intact for decades, describes the transfer of genetic information from DNA to protein though an RNA intermediate. While recent work has illustrated many exceptions to the central dogma, it is still a common model used to describe and study the relationship between genes and protein products. We investigated understanding of central dogma concepts and found that students are not primed to think about information when presented with the canonical figure of the central dogma. We also uncovered conceptual errors in student interpretation of the meaning of the transcription arrow in the central dogma representation; 36% of students (n = 128; all undergraduate levels) described transcription as a chemical conversion of DNA into RNA or suggested that RNA existed before the process of transcription began. Interviews confirm that students with weak conceptual understanding of information flow find inappropriate meaning in the canonical representation of central dogma. Therefore, we suggest that use of this representation during instruction can be counterproductive unless educators are explicit about the underlying meaning. © 2014 L. K. Wright et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Absolute becoming, relational becoming and the arrow of time: Some non-conventional remarks on the relationship between physics and metaphysics

Science.gov (United States)

Dorato, Mauro

The literature on the compatibility between the time of our experience-characterized by passage or becoming-and time as is represented within spacetime theories has been affected by a persistent failure to get a clear grasp of the notion of becoming, both in its relation to an ontology of events "spread" in a four-dimensional manifold, and in relation to temporally asymmetric physical processes. In the first part of my paper I try to remedy this situation by offering what I consider a clear and faithful explication of becoming, valid independently of the particular spacetime setting in which we operate. Along the way, I will show why the metaphysical debate between the so-called "presentists" and "eternalists" is completely irrelevant to the question of becoming, as the debate itself is generated by a failure to distinguish between a tensed and a tenseless sense of "existence". After a much needed distinction between absolute and relational becoming, I then show in what sense classical (non-quantum) spacetime physics presupposes both types of becoming, for the simple reason that spacetime physics presupposes an ontology of (timelike-separated) events. As a consequence, not only does it turn out that using physics to try to provide empirical evidence for the existence of becoming amounts to putting the cart before the horses, but also that the order imposed by "the arrow of becoming" is more fundamental than any other physical arrow of time, despite the fact that becoming cannot be used to explain why entropy grows, or retarded electromagnetic radiation prevails versus advanced radiation.

Micro-simulation of vehicle conflicts involving right-turn vehicles at signalized intersections based on cellular automata.

Science.gov (United States)

Chai, C; Wong, Y D

2014-02-01

At intersection, vehicles coming from different directions conflict with each other. Improper geometric design and signal settings at signalized intersection will increase occurrence of conflicts between road users and results in a reduction of the safety level. This study established a cellular automata (CA) model to simulate vehicular interactions involving right-turn vehicles (as similar to left-turn vehicles in US). Through various simulation scenarios for four case cross-intersections, the relationships between conflict occurrences involving right-turn vehicles with traffic volume and right-turn movement control strategies are analyzed. Impacts of traffic volume, permissive right-turn compared to red-amber-green (RAG) arrow, shared straight-through and right-turn lane as well as signal setting are estimated from simulation results. The simulation model is found to be able to provide reasonable assessment of conflicts through comparison of existed simulation approach and observed accidents. Through the proposed approach, prediction models for occurrences and severity of vehicle conflicts can be developed for various geometric layouts and traffic control strategies. Copyright © 2013 Elsevier Ltd. All rights reserved.

Study of the Decay {ital {tau}}{sup {minus}}{r_arrow}2{ital {pi} }{sup {minus}}{ital {pi}}{sup +} 3{ital {pi}}{sup 0}{ital {nu}}{sub {ital {tau} }}

Energy Technology Data Exchange (ETDEWEB)

Anderson, S.; Kubota, Y.; Lee, S. .; ONeill, J.J.; Patton, S.; Poling, R.; Riehle, T.; Savinov, V.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Homoelle, D.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [The Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Glenn, S.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Ugolini, D.; Wang, R.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; Stroynowski, R.; Volobouev, I.; Ye, J. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Efimov, A.; Goldberg, M.; He, D.; Kopp, S.; Moneti, G.C.; Mountain, R.; Schuh, S.; Skwarnicki, T.; Stone, S.; Viehhauser, G.; Xing, X. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; Jain, V.; McLean, K.W.; Marka, S. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Godang, R.; Kinoshita, K.; Lai, I.C.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; and others

1997-11-01

The decay {tau}{sup {minus}}{r_arrow}2{pi}{sup {minus}}{pi}{sup + }3{pi}{sup 0}{nu}{sub {tau}} has been studied with the CLEOII detector at the Cornell Electron Storage Ring. The branching fraction is measured to be (2.85{plus_minus}0.56{plus_minus}0.51){times}10{sup {minus}4} . The result is in good agreement with the isospin expectation but somewhat below the conserved-vector-current prediction. We have searched for resonance substructure in the decay. Within the statistical precision, the decay is saturated by the channels {tau}{sup {minus}}{r_arrow}{pi}{sup {minus}}2{pi}{sup 0 }{omega}{nu}{sub {tau}} , 2{pi}{sup {minus}}{pi}{sup +}{eta}{nu}{sub {tau}} , and {pi}{sup {minus}}2{pi}{sup 0}{eta}{nu}{sub {tau}} . This is the first observation of this {omega} decay mode and the branching fraction is measured to be (1.89{sup +0.74}{sub {minus}0.67}{plus_minus}0.40) {times}10{sup {minus}4} . {copyright} {ital 1997} {ital The American Physical Society}

Strong association between a splice mutation (IVS12+5G{r_arrow}A) and haplotype 6 in hereditary tyrosinemia type I

Energy Technology Data Exchange (ETDEWEB)

Tanguay, R.M.; St-Louis, M.; Gibson, K. [Universite Laval, Ste-Foy (Canada)] [and others

1994-09-01

Hereditary tyrosinemia type I (HT I; McKusick 276700) is a severe inborn error of tyrosine catabolism pathway caused by a deficiency of fumarylacetoacetate hydrolase (FAH). The highest frequency reported is the one in Saguenay-Lac St-Jean (Quebec, Canada) where 1:1,846 births are affected. The FAH gene has been cloned and several mutations have been described. Allele specific oligonucleotide (ASO) hybridization was used to examine the frequency of a splice (IVS12-5G{r_arrow}A) mutation recently reported and RFLP analysis was done to identify haplotypes related to HT I. The splice mutation was found on 45/50 alleles (90%) in patients from SLSJ and 12/66 (18%) alleles from patients world-wide. All 25 patients from the SLSJ region were positive with 20 being homozygous, indicating that this mutation is the major cause of HT I in French Canada. Of these 25 patients, 96% were positive for one haplotype called no 6 which is these 25 patients, 96% were positive for one haplotype called no 6 which is identified by TaqI, RsaI, BglII, MspI and KpnI digestions. These data show a really strong association between the mutation (IVS12+5G{r_arrow}A) and haplotype 6. Among our patients from around the world, {approximately}52% were positive for haplotype 6 indicating its strong relation with HT I. These results provide the rationale for DNA-based carrier testing for HT I in the F-C population at risk as well as in HT I patients in general.

Form factor ratio measurement in {Lambda}{sup +}{sub {ital c}}{r_arrow}{Lambda}{ital e}{sup +}{nu}{sub {ital e}}

Energy Technology Data Exchange (ETDEWEB)

Crawford, G.; Daubenmier, C.M.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Butler, F.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; McIlwain, R.L.; Miao, T.; Miller, D.H.; Modesitt, M.; Payne, D.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Battle, M.; Ernst, J.; Gibbons, L.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Wang, C.H.; Dominick, J.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Zadorozhny, P.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Rozen, Y.; Stone, S.; Xing, X.; Zhu, G.; Bartelt, J.; Csorna, S.E.; Egyed, Z.; Jain, V.; Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Barish, B.; Chadha, M.; Chan, S.; Cowen, D.F.; Eigen, G.; Miller, J.S.; O`Grady, C.; Urheim, J.; Weinstein, A.J.; Athanas, M.; Brower, W.; Masek, G.; Paar, H.P.; Gronberg, J.; Korte, C.M.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Ryd, A.; Sperka, D.; Tajima, H.; Witherell, M.S.; Procario, M.; Balest, R.; Cho, K.; Ford, W.T.; Johnson, D.R.; Lingel, K.; Lohner, M.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Gaidarev, P.; Garcia-Sciveres, M.; Geiser, B.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Salman, S.; Sapper, M.; Wuerthwein, F.; Avery, P.; Freyberger, A.; Rodriguez, J.; Yang, S.; Yelton, J.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; (CLEO Collaboration)

1995-07-24

The angular distributions of the decay {Lambda}{sup +}{sub {ital c}}{r_arrow}{Lambda}{ital e}{sup +}{nu}{sub {ital e}} have been studied using the CLEO II detector. By performing a three-dimensional maximum likelihood fit, the form factor ratio {ital R}={ital f}{sub 2}/{ital f}{sub 1} is determined to be {minus}0.25{plus_minus}0.14{plus_minus}0.08. The decay asymmetry parameter of the {Lambda}{sub {ital c}} averaged over {ital q}{sup 2} is calculated to be {alpha}{sub {Lambda}{sub {ital c}}}={minus}0.82{sub {minus}0.06{minus}0.03}{sup +0.09+0.06}.

The Effects of Attention Cueing on Visualizers' Multimedia Learning

Science.gov (United States)

Yang, Hui-Yu

2016-01-01

The present study examines how various types of attention cueing and cognitive preference affect learners' comprehension of a cardiovascular system and cognitive load. EFL learners were randomly assigned to one of four conditions: non-signal, static-blood-signal, static-blood-static-arrow-signal, and animation-signal. The results indicated that…

ARGX-87: Accident Response Group Exercise, 1987: A Broken Arrow mini exercise

International Nuclear Information System (INIS)

Schuld, E.P.; Cruff, D.F.

1987-07-01

A Broken Arrow mini exercise dubbed ''Accident Response Group Exercise - 1987'' (ARGX-87) was conducted on June 1, 1987 at the Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories, Livermore (SNLL). The exercise started at 0445 PDT with a call from the Department of Energy (DOE) - EOC in Washington, DC, to the Albuquerque Operations (AL - ) - EOC. AL, in turn, called the Laboratory off-hour emergency number (Fire Dispatcher), who called the Laboratory Emergency Duty Officer (LEDO). The LEDO then contacted the Accident Response Group (ARG) Senior Scientific Advisor. Calls were placed to assemble appropriate members of the ARG in the ALERT Center. No phone number for SNLL was available at the Albuquerque Operations EOC, so a controller injected a message to SNLL to get them involved in the exercise. The messages received at the Laboratory identified the Air Force line item weapon system involved in the accident and the accident location. As people arrived at the ALERT Center they began discussing the details of the accident. They also started working the deployment logistics and other issues. Travel arrangements for the HOT SPOT equipment and ARG personnel were made for immediate deployment to the accident site in North Dakota. The exercise was terminated at 0840 as planned. While certain procedural deficiencies were noted, the exercise was considered a valuable learning experience. The results and observations from this experience will be used to refine the operating procedures and the training program

A reaction time advantage for calculating beliefs over public representations signals domain specificity for 'theory of mind'.

Science.gov (United States)

Cohen, Adam S; German, Tamsin C

2010-06-01

In a task where participants' overt task was to track the location of an object across a sequence of events, reaction times to unpredictable probes requiring an inference about a social agent's beliefs about the location of that object were obtained. Reaction times to false belief situations were faster than responses about the (false) contents of a map showing the location of the object (Experiment 1) and about the (false) direction of an arrow signaling the location of the object (Experiment 2). These results are consistent with developmental, neuro-imaging and neuropsychological evidence that there exist domain specific mechanisms within human cognition for encoding and reasoning about mental states. Specialization of these mechanisms may arise from either core cognitive architecture or via the accumulation of expertise in the social domain.

Observation of High Momentum {ital {eta}}{sup {prime}} Production in {ital B} Decays

Energy Technology Data Exchange (ETDEWEB)

Browder, T.E.; Li, Y.; Rodriguez, J.L. [University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Urbana-Champaign, Illinois 61801 (United States); Edwards, K.W.; Edwards, K.W. [the Institute of Particle Physics, Montreal, Quebec (Canada); Bellerive, A.; Bellerive, A.; Janicek, R.; Janicek, R.; MacFarlane, D.B.; MacFarlane, D.B.; Patel, P.M.; Patel, P.M. [the Institute of Particle Physics, Montreal, Quebec (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Kotov, S.; Kravchenko, I.; Kwak, N.; Zhou, L. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lee, S.J.; ONeill, J.J.; Poling, R.; Riehle, T.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wolf, A.; Zoeller, M.M. [The Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Severini, H.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Glenn, S.; Kwon, Y.; Lyon, A.L.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Savinov, V.; Ugolini, D.; Zhou, X.; and others

1998-08-01

We report the first observation of B{r_arrow}{eta}{sup {prime}}X transitions with high momentum {eta}{sup {prime}} mesons. We observe 39.0{plus_minus}11.6 B decay events with 2.0{lt}p{sub {eta}{sup {prime}}}{lt}2.7 GeV/c , the high momentum region where background from b{r_arrow}c processes is suppressed. We discuss the physical interpretation of the signal, including the possibility that it is due to b{r_arrow}sg{sup {asterisk}} transitions. Given that interpretation, we find B(B{r_arrow}{eta}{sup {prime}}X{sub s} )=[6.2{plus_minus}1.6(stat){plus_minus} 1.3(syst){sup +0.0}{sub {minus}1.5} (bkg)]{times}10{sup {minus}4} for 2.0{lt}p{sub {eta}{sup {prime}}}{lt}2.7 GeV/c . {copyright} {ital 1998} {ital The American Physical Society }

Road work zone accident studies : Advanced Research On Road Work Zone Safety Standard in Europe ARROWS Task 2.2 internal report. On behalf of the European Union, Directorate-General for Transport DG VII-E3, Transport RTD Programme.

NARCIS (Netherlands)

Gundy, C.M.

1998-01-01

The primary objective of this study, part of the ARROWS (Advanced Research on Road Work Zone Safety Standards in Europe) project, is to draw conclusions about the nature and extent of work zone traffic accidents. To that end, existing empirical studies concerning work zone traffic accidents have

Temporal Asymmetry, Entropic Irreversibility, and Finite-Time Thermodynamics: From Parmenides–Einstein Time-Reversal Symmetry to the Heraclitan Entropic Arrow of Time

Directory of Open Access Journals (Sweden)

Wassim M. Haddad

2012-02-01

Full Text Available In this paper, we combine the two universalisms of thermodynamics and dynamical systems theory to develop a dynamical system formalism for classical thermodynamics. Specifically, using a compartmental dynamical system energy flow model we develop a state-space dynamical system model that captures the key aspects of thermodynamics, including its fundamental laws. In addition, we establish the existence of a unique, continuously differentiable global entropy function for our dynamical system model, and using Lyapunov stability theory we show that the proposed thermodynamic model has finite-time convergent trajectories to Lyapunov stable equilibria determined by the system initial energies. Finally, using the system entropy, we establish the absence of Poincaré recurrence for our thermodynamic model and develop clear and rigorous connections between irreversibility, the second law of thermodynamics, and the entropic arrow of time.

1g(9/2), 1f(5/2), and 1f(7/2) neutron inner hole responses in Sn-115 and Sn-119 via the ((d)over-right-arrow,t) reaction at E-d=200 MeV

NARCIS (Netherlands)

Langevin-Joliot, H; Van de Wiele, J; Guillot, J; Gerlic, E; Rosier, LH; Willis, A; Djalali, C; Morlet, M; Tomasi-Gustafsson, E; Blasi, N; Micheletti, S; van der Werf, SY

Neutron inner hole responses in Sn-115 and Sn-119 nuclei have been studied via the ((d) over right arrow ,t) reaction at E-d=200 MeV using a polarized beam with both vector and tensor components. One-step pickup observables corresponding to the overlapping 1g(9/2), 1f(5/2), and 1f(7/2) responses

Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration, task 3

Science.gov (United States)

1978-01-01

A structural design study was conducted to assess the relative merits of structural concepts using advanced composite materials for an advanced supersonic aircraft cruising at Mach 2.7. The configuration and structural arrangement developed during Task I and II of the study, was used as the baseline configuration. Allowable stresses and strains were established for boron and advanced graphite fibers based on projected fiber properties available in the next decade. Structural concepts were designed and analyzed using graphite polyimide and boron polyimide, applied to stiffened panels and conventional sandwich panels. The conventional sandwich panels were selected as the structural concept to be used on the wing structure. The upper and lower surface panels of the Task I arrow wing were redesigned using high-strength graphite polyimide sandwich panels over the titanium spars and ribs. The ATLAS computer system was used as the basis for stress analysis and resizing the surface panels using the loads from the Task II study, without adjustment for change in aeroelastic deformation. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter speed was increased to that of the titanium wing, with a weight penalty less than that of the metallic airplane.

Threshold responses of Blackside Dace (Chrosomus cumberlandensis) and Kentucky Arrow Darter (Etheostoma spilotum) to stream conductivity

Science.gov (United States)

Hitt, Nathaniel P.; Floyd, Michael; Compton, Michael; McDonald, Kenneth

2016-01-01

Chrosomus cumberlandensis (Blackside Dace [BSD]) and Etheostoma spilotum (Kentucky Arrow Darter [KAD]) are fish species of conservation concern due to their fragmented distributions, their low population sizes, and threats from anthropogenic stressors in the southeastern United States. We evaluated the relationship between fish abundance and stream conductivity, an index of environmental quality and potential physiological stressor. We modeled occurrence and abundance of KAD in the upper Kentucky River basin (208 samples) and BSD in the upper Cumberland River basin (294 samples) for sites sampled between 2003 and 2013. Segmented regression indicated a conductivity change-point for BSD abundance at 343 μS/cm (95% CI: 123–563 μS/cm) and for KAD abundance at 261 μS/cm (95% CI: 151–370 μS/cm). In both cases, abundances were negligible above estimated conductivity change-points. Post-hoc randomizations accounted for variance in estimated change points due to unequal sample sizes across the conductivity gradients. Boosted regression-tree analysis indicated stronger effects of conductivity than other natural and anthropogenic factors known to influence stream fishes. Boosted regression trees further indicated threshold responses of BSD and KAD occurrence to conductivity gradients in support of segmented regression results. We suggest that the observed conductivity relationship may indicate energetic limitations for insectivorous fishes due to changes in benthic macroinvertebrate community composition.

Box-and-arrow explanations need not be more abstract than neuroscientific mechanism descriptions.

Science.gov (United States)

Datteri, Edoardo; Laudisa, Federico

2014-01-01

The nature of the relationship between box-and-arrow (BA) explanations and neuroscientific mechanism descriptions (NMDs) is a key foundational issue for cognitive science. In this article we attempt to identify the nature of the constraints imposed by BA explanations on the formulation of NMDs. On the basis of a case study about motor control, we argue that BA explanations and NMDs both identify regularities that hold in the system, and that these regularities place constraints on the formulation of NMDs from BA analyses, and vice versa. The regularities identified in the two kinds of explanation play a crucial role in reasoning about the relationship between them, and in justifying the use of neuroscientific experimental techniques for the empirical testing of BA analyses of behavior. In addition, we make claims concerning the similarities and differences between BA analyses and NMDs. First, we argue that both types of explanation describe mechanisms. Second, we propose that they differ in terms of the theoretical vocabulary used to denote the entities and properties involved in the mechanism and engaging in regular, mutual interactions. On the contrary, the notion of abstractness, defined as omission of detail, does not help to distinguish BA analyses from NMDs: there is a sense in which BA analyses are more detailed than NMDs. In relation to this, we also focus on the nature of the extra detail included in NMDs and missing from BA analyses, arguing that such detail does not always concern how the system works. Finally, we propose reasons for doubting that BA analyses, unlike NMDs, may be considered "mechanism sketches." We have developed these views by critically analyzing recent claims in the philosophical literature regarding the foundations of cognitive science.

Box-and-arrow explanations need not be more abstract than neuroscientific mechanism descriptions

Directory of Open Access Journals (Sweden)

Edoardo eDatteri

2014-05-01

Full Text Available The nature of the relationship between box-and-arrow (BA explanations and neuroscientific mechanism descriptions (NMDs is a key foundational issue for cognitive science. In this article we attempt to identify the nature of the constraints imposed by BA explanations on the formulation of NMDs. On the basis of a case study about motor control, we argue that BA explanations and NMDs both identify regularities that hold in the system, and that these regularities place constraints on the formulation of NMDs from BA analyses, and vice versa. The regularities identified in the two kinds of explanation play a crucial role in reasoning about the relationship between them, and in justifying the use of neuroscientific experimental techniques for the empirical testing of BA analyses of behavior. In addition, we make claims concerning the similarities and differences between BA analyses and NMDs. First, we argue that both types of explanation describe mechanisms. Second, we propose that they differ in terms of the theoretical vocabulary used to denote the entities and properties involved in the mechanism and engaging in regular, mutual interactions. On the contrary, the notion of abstractness, defined as omission of detail, does not help to distinguish BA analyses from NMDs: there is a sense in which BA analyses are more detailed than NMDs. In relation to this, we also focus on the nature of the extra detail included in NMDs and missing from BA analyses, arguing that such detail does not always concern how the system works. Finally, we propose reasons for doubting that BA analyses, unlike NMDs, may be considered mechanism sketches. We have developed these views by critically analyzing recent claims in the philosophical literature regarding the foundations of cognitive science.

Signal transfer within a cultured asymmetric cortical neuron circuit.

Science.gov (United States)

Isomura, Takuya; Shimba, Kenta; Takayama, Yuzo; Takeuchi, Akimasa; Kotani, Kiyoshi; Jimbo, Yasuhiko

2015-12-01

Simplified neuronal circuits are required for investigating information representation in nervous systems and for validating theoretical neural network models. Here, we developed patterned neuronal circuits using micro fabricated devices, comprising a micro-well array bonded to a microelectrode-array substrate. The micro-well array consisted of micrometre-scale wells connected by tunnels, all contained within a silicone slab called a micro-chamber. The design of the micro-chamber confined somata to the wells and allowed axons to grow through the tunnels bidirectionally but with a designed, unidirectional bias. We guided axons into the point of the arrow structure where one of the two tunnel entrances is located, making that the preferred direction. When rat cortical neurons were cultured in the wells, their axons grew through the tunnels and connected to neurons in adjoining wells. Unidirectional burst transfers and other asymmetric signal-propagation phenomena were observed via the substrate-embedded electrodes. Seventy-nine percent of burst transfers were in the forward direction. We also observed rapid propagation of activity from sites of local electrical stimulation, and significant effects of inhibitory synapse blockade on bursting activity. These results suggest that this simple, substrate-controlled neuronal circuit can be applied to develop in vitro models of the function of cortical microcircuits or deep neural networks, better to elucidate the laws governing the dynamics of neuronal networks.

Signal transfer within a cultured asymmetric cortical neuron circuit

Science.gov (United States)

Isomura, Takuya; Shimba, Kenta; Takayama, Yuzo; Takeuchi, Akimasa; Kotani, Kiyoshi; Jimbo, Yasuhiko

2015-12-01

Objective. Simplified neuronal circuits are required for investigating information representation in nervous systems and for validating theoretical neural network models. Here, we developed patterned neuronal circuits using micro fabricated devices, comprising a micro-well array bonded to a microelectrode-array substrate. Approach. The micro-well array consisted of micrometre-scale wells connected by tunnels, all contained within a silicone slab called a micro-chamber. The design of the micro-chamber confined somata to the wells and allowed axons to grow through the tunnels bidirectionally but with a designed, unidirectional bias. We guided axons into the point of the arrow structure where one of the two tunnel entrances is located, making that the preferred direction. Main results. When rat cortical neurons were cultured in the wells, their axons grew through the tunnels and connected to neurons in adjoining wells. Unidirectional burst transfers and other asymmetric signal-propagation phenomena were observed via the substrate-embedded electrodes. Seventy-nine percent of burst transfers were in the forward direction. We also observed rapid propagation of activity from sites of local electrical stimulation, and significant effects of inhibitory synapse blockade on bursting activity. Significance. These results suggest that this simple, substrate-controlled neuronal circuit can be applied to develop in vitro models of the function of cortical microcircuits or deep neural networks, better to elucidate the laws governing the dynamics of neuronal networks.

Measurement of proton polarization in the reaction. gamma. /ital p//r arrow//ital p/. pi. /sup 0/ at an angle theta/sup *//sub. pi. /sup 0//=80/degree/ in a linearly polarized photon beam

Energy Technology Data Exchange (ETDEWEB)

Avakyan, R. O.; Avakyan, E. O.; Avetisyan, A. E.; Aivazyan, R. B.; Arestakesyan, G. A.; Bagdasryan, A. S.; Vartapetyan, G. A.; Garibyan, Y. A.; Eganov, V. S.; Karapetyan, A. P.; and others

1988-12-01

Measurements are reported of the energy dependence of the /ital p//sub /ital xz// and /ital P//sub /ital y// components of the polarization vector of the recoil protons in the reaction ..gamma../ital p//r arrow//ital p/..pi../sup 0/ for a ..pi../sup 0/-meson production angle theta/sup *//sub ..pi../sup 0// =80/degree/ in the c.m.s. in the ..gamma..-ray energy range /ital E//sub ..gamma../=730--1066 MeV. The experimental data are compared with the results of various phenomenological analyses.

Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells

Energy Technology Data Exchange (ETDEWEB)

Green, A.C. [St Vincent' s Institute, Fitzroy, Victoria 3065 (Australia); Department of Medicine at St. Vincent' s Hospital, The University of Melbourne, Victoria 3065 (Australia); Kocovski, P.; Jovic, T.; Walia, M.K. [St Vincent' s Institute, Fitzroy, Victoria 3065 (Australia); Chandraratna, R.A.S. [IO Therapeutics, Inc., Santa Ana, CA 92705 (United States); Martin, T.J.; Baker, E.K. [St Vincent' s Institute, Fitzroy, Victoria 3065 (Australia); Department of Medicine at St. Vincent' s Hospital, The University of Melbourne, Victoria 3065 (Australia); Purton, L.E., E-mail: lpurton@svi.edu.au [St Vincent' s Institute, Fitzroy, Victoria 3065 (Australia); Department of Medicine at St. Vincent' s Hospital, The University of Melbourne, Victoria 3065 (Australia)

2017-01-01

Low and high serum retinol levels are associated with increased fracture risk and poor bone health. We recently showed retinoic acid receptors (RARs) are negative regulators of osteoclastogenesis. Here we show RARs are also negative regulators of osteoblast and adipocyte differentiation. The pan-RAR agonist, all-trans retinoic acid (ATRA), directly inhibited differentiation and mineralisation of early osteoprogenitors and impaired the differentiation of more mature osteoblast populations. In contrast, the pan-RAR antagonist, IRX4310, accelerated differentiation of early osteoprogenitors. These effects predominantly occurred via RARγ and were further enhanced by an RARα agonist or antagonist, respectively. RAR agonists similarly impaired adipogenesis in osteogenic cultures. RAR agonist treatment resulted in significant upregulation of the Wnt antagonist, Sfrp4. This accompanied reduced nuclear and cytosolic β-catenin protein and reduced expression of the Wnt target gene Axin2, suggesting impaired Wnt/β-catenin signalling. To determine the effect of RAR inhibition in post-natal mice, IRX4310 was administered to male mice for 10 days and bones were assessed by µCT. No change to trabecular bone volume was observed, however, radial bone growth was impaired. These studies show RARs directly influence osteoblast and adipocyte formation from mesenchymal cells, and inhibition of RAR signalling in vivo impairs radial bone growth in post-natal mice. - Graphical abstract: Schematic shows RAR ligand regulation of osteoblast differentiation in vitro. RARγ antagonists±RARα antagonists promote osteoblast differentiation. RARγ and RARα agonists alone or in combination block osteoblast differentiation, which correlates with upregulation of Sfrp4, and downregulation of nuclear and cytosolic β-catenin and reduced expression of the Wnt target gene Axin2. Red arrows indicate effects of RAR agonists on mediators of Wnt signalling.

Curly arrows meet electron density transfers in chemical reaction mechanisms: from electron localization function (ELF) analysis to valence-shell electron-pair repulsion (VSEPR) inspired interpretation.

Science.gov (United States)

Andrés, Juan; Berski, Sławomir; Silvi, Bernard

2016-07-07

Probing the electron density transfers during a chemical reaction can provide important insights, making possible to understand and control chemical reactions. This aim has required extensions of the relationships between the traditional chemical concepts and the quantum mechanical ones. The present work examines the detailed chemical insights that have been generated through 100 years of work worldwide on G. N. Lewis's ground breaking paper on The Atom and the Molecule (Lewis, G. N. The Atom and the Molecule, J. Am. Chem. Soc. 1916, 38, 762-785), with a focus on how the determination of reaction mechanisms can be reached applying the bonding evolution theory (BET), emphasizing how curly arrows meet electron density transfers in chemical reaction mechanisms and how the Lewis structure can be recovered. BET that combines the topological analysis of the electron localization function (ELF) and Thom's catastrophe theory (CT) provides a powerful tool providing insight into molecular mechanisms of chemical rearrangements. In agreement with physical laws and quantum theoretical insights, BET can be considered as an appropriate tool to tackle chemical reactivity with a wide range of possible applications. Likewise, the present approach retrieves the classical curly arrows used to describe the rearrangements of chemical bonds for a given reaction mechanism, providing detailed physical grounds for this type of representation. The ideas underlying the valence-shell-electron pair-repulsion (VSEPR) model applied to non-equilibrium geometries provide simple chemical explanations of density transfers. For a given geometry around a central atom, the arrangement of the electronic domain may comply or not with the VSEPR rules according with the valence shell population of the considered atom. A deformation yields arrangements which are either VSEPR defective (at least a domain is missing to match the VSEPR arrangement corresponding to the geometry of the ligands), VSEPR compliant

Meaurement of the target single-spin asymmetry in quasi-elastic region from the reaction {sup 3}He{up_arrow}(e,e')

Energy Technology Data Exchange (ETDEWEB)

Zhang, Yawei [Rutgers

2013-10-01

A measurement of the inclusive target single-spin asymmetry has been performed using the quasi-elastic {sup 3}He{up_arrow}(e,e') reaction with a vertically polarized {sup 3}He target at Q{sup 2} values of 0.13, 0.46 and 0.97 GeV{sup 2}. This asymmetry vanishes under the one photon exchange assumption. But the interference between two-photon exchange and one-photon exchange gives rise to an imaginary amplitude, so that a non-zero A{sub y} is allowed. The experiment, conducted in Hall A of Jefferson Laboratory in 2009, used two independent spectrometers to simultaneously measure the target single-spin asymmetry. Using the effective polarization approximation, the neutron single-spin asymmetries were extracted from the measured {sup 3}He asymmetries. The measurement is to establish a non-vanishing A{sub y}. Non-zero asymmetries were observed at all Q{sup 2} points, and the overall precision is an order of magnitude improved over the existing proton data. The data provide new constraints on Generalized Parton Distribution (GPD) models and new information on the dynamics of the two-photon exchange process.

Search for B_c^± arrow J/ψ μ^± X Decays in pbarp Collisions at √s=1.8 TeV

Science.gov (United States)

Singh, Prem

1997-04-01

The B_c^± meson, a bound state of charm and bottom quarks, is expected to have several narrow mass states below the B--D open flavor threshold. We describe a search for the weak decays of the B_c^± produced in a 110 pb-1 sample of √s= 1.8 TeV proton-antiproton collisions in the CDF detector at the Fermilab Tevatron. A high branching ratio of B_c^± to J/ψ decays permits an effective trigger on these events. The search is conducted through the decay B_c^± arrow J/ψ μ^± X. Supported by U.S. DOE under Contract No. DE-FG02-91ER40646. We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Science and Culture of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; and the A. P. Sloan Foundation.

75 FR 56531 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

Science.gov (United States)

2010-09-16

...) submitted to OMB: (1) Go to the web page http://reginfo.gov/public/do/PRAMain , (2) look for the section of the web page called ``Currently Under Review'', (3) click on the downward-pointing arrow in the... television translators whose station identification is made by the television station whose signals are being...

From arrow poison to herbal medicine--the ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae).

Science.gov (United States)

Semwal, Deepak Kumar; Semwal, Ruchi Badoni; Vermaak, Ilze; Viljoen, Alvaro

2014-09-11

Cissampelos species have a rich history of traditional use, being used for both therapeutic and toxic properties. It is traditionally applied therapeutically in a diverse range of conditions and diseases including asthma, cough, fever, arthritis, obesity, dysentery, snakebite, jaundice and heart, blood pressure and skin-related problems. Conversely, it was traditionally included in preparations of curare applied as arrow poison during hunting to cause death of animals by asphyxiation. This review unites the ethnobotanical knowledge on Cissampelos with the phytochemistry and pharmacological activity which has been explored thus far. In addition, it identifies knowledge gaps and suggests further research opportunities. The available electronic literature on the genus Cissampelos was collected using database searches including Scopus, Google Scholar, Pubmed, Web of Science, etc. The searches were limited to peer-reviewed English journals with the exception of books and a few articles in foreign languages which were included. The literature revealed that pharmacological activity including analgesic and antipyretic, anti-inflammatory, anti-allergic, bronchodilator, immunomodulatory, memory-enhancing, antidepressant, neuroprotective, antimicrobial, antimalarial, antiparasitic, anti-ulcer, anticancer, anti-oxidant, cardiovascular, muscle-relaxant, hepatoprotective, antidiabetic, antidiarrhoeal, antifertility, and antivenom activity have been confirmed in vitro and/or in vivo for various Cissampelos species. Cissampelos pareira L. and Cissampelos sympodialis Eichl. are the most explored species of this genus and the smallest number of studies have been conducted on Cissampelos laxiflora Moldenke and Cissampelos tenuipes Engl. Many alkaloids isolated from Cissampelos such as warifteine, methylwarifteine, berberine, hayatin and hayatidin showed promising anti-allergic, immunosuppressive, antidepressant, anticancer, vasodilatory and muscle-relaxant activities. The plants of

Spinal Cord Injury 101

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Full Text Available ... injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a spinal cord injury important? play_arrow What role does “compression” play in a spinal cord injury? play_arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

Working Memory Capacity in a Go/No-Go Task: Age Differences in Interference, Processing Speed, and Attentional Control

Science.gov (United States)

Rodríguez-Villagra, Odir Antonio; Göthe, Katrin; Oberauer, Klaus; Kliegl, Reinhold

2013-01-01

We tested the limits of working-memory capacity (WMC) of young adults, old adults, and children with a memory-updating task. The task consisted of mentally shifting spatial positions within a grid according to arrows, their color signaling either only go (control) or go/no-go conditions. The interference model (IM) of Oberauer and Kliegl (2006)…

Preventing Pressure Sores

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Full Text Available ... cord injuries? play_arrow Why are pressure sores so serious? play_arrow What is "sepsis," and why ... pressure sores? play_arrow Why is pressure relief so important when sitting in a wheelchair? play_arrow ...

Spinal Cord Injury 101

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Full Text Available ... spinal cord injuries? play_arrow What is “Braingate” research? play_arrow How would stem-cell therapies work ... cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can ...

Preventing Pressure Sores

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Full Text Available ... arrow Is it true that a pressure sore can develop in a few hours? play_arrow What's ... play_arrow What is “skin tolerance” and how can it be increased? play_arrow What do family ...

Sex and Fertility After SCI

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Full Text Available ... arrow How should people deal with spasticity during sex? play_arrow What about positions and foreplay after a spinal cord injury? play_arrow What about orgasms and sensation during sex after a spinal cord injury? play_arrow What ...

Analysis of changed bio-signal to radiation exposure of nuclear medicine worker

International Nuclear Information System (INIS)

Lee, Hwun Jae; Lee, Sang Bock

2007-01-01

In this paper, we are evaluated about bio-signal between general workers and nuclear medicine workers which is more radiation exposure relatively. In order to reciprocal evaluated two group, we experimented nuclear medicine workers in Chung-Buk National University Hospital at department of nuclear medicine and worker in Chon-Nam National University Hospital at CT room, general radiographic room, medical recording room, receipt room, general office room. Used of experimental equipments as follows, for a level of radiation measurement by pocket dosimeter which made by Arrow-Tech company, for heart rate and blood pressure measurement by TONOPORT V which made by GE medical systems company, for heat flux and skin temperature and energy expenditure measurement by Armband senseware 2000 which made by Bodymedia company. Result of experiment obtains as follows : 1) Individual radiation exposure is recorded 3.05 uSv at department of nuclear medicine and order as follows CT room, general radiograpic room, medical recording room, receipt room, general office room. Department of nuclear medicine more 1.5 times than other places. 2) Radiation accumulated dose is not related to Heat flux, Skin temperature, Energy expenditure. 3) Blood pressure is recorded equal to nuclear medical workers, general officer, general people about systolic blood pressure and diastolic blood pressure. Compared to blood pressure between nuclear medical works which is more radiation exposure and other workers was not changed. Consequently, more radiation exposed workers at nuclear medicine field doesn't have hazard

Spinal Cord Injury 101

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Full Text Available ... arrow What is the “Spinal Cord Injury Model Systems” program? play_arrow What are the most promising new treatments for spinal cord injuries? play_arrow What are the latest developments in the use of electrical stimulation for spinal cord injuries? play_arrow ...

Geometric patterns of time-delay plots from different cardiac rhythms and arrhythmias using short-term EKG signals.

Science.gov (United States)

Borracci, Raúl A; Montoya Pulvet, José D; Ingino, Carlos A; Fitz Maurice, Mario; Hirschon Prado, Alfredo; Dominé, Enrique

2017-12-27

To date, no systematic work has been intended to describe spatio-temporal patterns of cardiac rhythms using only short series of RR intervals, to facilitate visual or computerized-aided identification of EKG motifs for use in clinical practice. The aim of this study was to detect and classify eye-catching geometric patterns of Poincaré time-delay plots from different types of cardiac rhythms and arrhythmias using short-term EKG signals. Approximately 150-300 representative, consecutive beats were retrieved from 24-h Holter registers of 100 patients with different heart rhythms. Two-dimensional Poincaré charts were created, and the resulting geometric patterns were transformed into representative familiar eye-catching drawings to interpret different arrhythmias. Poincaré plot representation of RR interval data revealed a wide variety of visual patterns: (i) comet-shaped for sinus rhythm; (ii) torpedo-shaped for sinus bradycardia; (iii) cigarette-shaped for sinus tachycardia; (iv) butterfly-shaped for sinus tachycardia and isolated atrial premature complexes; (v) arrow-shaped for isolated premature complexes and inappropriate sinus tachycardia; (vi) inverted fan-shaped for sinus rhythm with frequent atrial premature complexes; (vii) tornado-shaped for atrial flutter and atrial tachycardia; and (viii) fan-shaped for atrial fibrillation. Modified Poincaré plots with smoothed lines connecting successive points could accurately classify different types of arrhythmias based on short RR interval sequence variability. Characteristic emergent patterns can be visually identified and eventually could be distinguished by an automatic classification system able to discern between arrhythmias. This work provides an alternative method to interpret time-delay plots obtained from short-term EKG signal recordings. © 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

Spinal Cord Injury 101

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Sex and Fertility After SCI

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Full Text Available ... arrow How does caregiving for your partner often affect romantic relationships? play_arrow What are the common treatments for ... play_arrow How does a spinal cord injury affect male fertility? play_arrow Where can people get information on sex and ... Contact Us Terms of Use Site Map ...

Study of flavor-tagged baryon production in B decay

Energy Technology Data Exchange (ETDEWEB)

Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N. [University of Kansas, Lawrence, Kansas 66045 (United States); Kubota, Y.; Lattery, M.; Nelson, J.K.; Patton, S.; Poling, R.; Riehle, T.; Savinov, V.; Wang, R. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; ONeill, J.J.; Severini, H.; Sun, C.R.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Crawford, G.; Duboscq, J.E.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio, 43210 (United States); Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.; Wang, P.N. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Stroynowski, R.; Volobouev, I.; Wei, G. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Kopp, S.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.; Skwarnicki, T.; Stone, S.; Xing, X. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; Jain, V.; Marka, S. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Gibaut, D.; Kinoshita, K.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Barish, B.; Chadha, M.; Chan, S.; Cowen, D.

1997-01-01

Using data collected on the {Upsilon}(4S) resonance and the nearby continuum by the CLEO-II detector, we have studied combinations of baryons with leptons produced in the process {Upsilon}(4S){r_arrow}B{bar B}, B{r_arrow}lepton+X, {bar B}{r_arrow}baryon+X. Our results do not support models which Attribute the bulk of {Lambda}{sub c} production in {bar B} decay to the process b{r_arrow}cW{sup {minus}},W{sup {minus}}{r_arrow}{bar c}s. {copyright} {ital 1997} {ital The American Physical Society}

Preventing Pressure Sores

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How different location modes influence responses in a Simon-like task.

Science.gov (United States)

Luo, Chunming; Proctor, Robert W

2017-11-01

Spatial information can be conveyed not only by stimulus position but by the meaning of a location word or direction of an arrow. We examined whether all the location-, arrow- and word-based Simon effects or some of them can be observed when a location word or an arrow is presented eccentrically and a left-right keypress is made to indicate its ink color. Results showed that only the location-based Simon effect was observed for location words, whereas an additional smaller arrow-based Simon effect, compared to the location-based Simon effect was observed, for arrows. These results showed spatial location, arrow direction, and location word stimulus dimensions affect response position codes in a spatial-to-verbal priority order, consistent with the possibility that they can activate mode-specific spatial representations.

Spinal Cord Injury 101

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Sex and Fertility After SCI

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Preventing Pressure Sores

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Preventing Pressure Sores

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Spinal Cord Injury 101

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Full Text Available ... Braingate” research? play_arrow How would stem-cell therapies work in the treatment of spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can we expect ...

Spinal Cord Injury 101

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Full Text Available ... What is “Braingate” research? play_arrow How would stem-cell therapies work in the treatment of spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When ...

Preventing Pressure Sores

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Full Text Available ... play_arrow What is "sepsis," and why is it dangerous? play_arrow How common are pressure sores ... likely to develop pressure sores? play_arrow Is it true that a pressure sore can develop in ...

Sex and Fertility After SCI

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Full Text Available ... arrow What are the common treatments for erectile dysfunction in men with spinal cord injuries? play_arrow ... to know about using oral medications for erectile dysfunction? play_arrow What do people do with a ...

Sex and Fertility After SCI

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Full Text Available ... after a spinal cord injury? play_arrow Can men and women still have sex after a spinal ... injury? play_arrow How is sexual function in men affected by a spinal cord injury ? play_arrow ...

Preventing Pressure Sores

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Full Text Available ... of a pressure sore required? play_arrow How long is the typical healing time for a pressure ... arrow Why do some pressure sores take so long to heal? play_arrow Can a pressure sore ...

Preventing Pressure Sores

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Measurement of the angular distribution of the electron from W {r_arrow} e = {nu} decay, in p pbar at {radical}s = 1.8 TeV, as function of P{sub T}{sup W}

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-06-01

The goal of this work is to study the behavior of the angular distribution of the electron from the decay of the W boson in a specific rest frame of the W, the Collins-Soper frame. More specifically, the parameter {alpha}{sub 2} from the expression d{sigma}/d(P{sub T}{sup W}){sup 2} d cos {theta}* = k(1 + {alpha}{sub 2} cos {theta}* + {alpha}{sup 2}(cos {theta}*){sup 2}), corresponding to the distribution of cos {theta}* in the Collins-Soper frame, was measured. The experimental value of {alpha}P{sub 2} was compared with the predictions made by E. Mirkes [11] who included the radiative QCD perturbations in the weak-interaction B{sub boson} {r_arrow} lepton + lepton. This experimental value was extracted for the first time using knowledge about how the radiative QCD perturbations will modify the predictions given by the Electro-Weak process only.

Preventing Pressure Sores

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Sex and Fertility After SCI

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Full Text Available ... oral medications for erectile dysfunction? play_arrow What do people do with a catheter during sex? play_arrow How ... after a spinal cord injury? play_arrow How do women deal with menstruation after a spinal cord ...

Spinal Cord Injury 101

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Time symmetry and asymmetry in quantum mechanics and quantum cosmology

International Nuclear Information System (INIS)

Gell-Mann, M.; Hartle, J.B.

1992-01-01

The disparity between the time symmetry of the fundamental laws of physics and the time asymmetries of the observed universe has been a subject of fascination for physicists since the late 19th century. It was also for Sakharov, if the authors judge correctly from his writings the following general time asymmetries are observed in this universe: The thermodynamic arrow of time --- the fact that approximately isolated systems are now almost all evolving towards equilibrium in the same direction of time. The psychological arrow of time --- we remember the past, we predict the future. The arrow of time of retarded electromagnetic radiation. The arrow of time supplied by the CP non-invariance of the weak interactions and the CPT invariance of field theory. The arrow of time of the approximately uniform expansion of the universe. The arrow of time supplied by the growth of inhomogeneity in the expanding universe

Retroactive signaling in short signaling pathways.

Directory of Open Access Journals (Sweden)

Jacques-Alexandre Sepulchre

Full Text Available In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles.

Determination of proton-nucleon analyzing powers and spin-rotation-depolarization parameters at 500 MeV

International Nuclear Information System (INIS)

Marshall, J.A.; Barlett, M.L.; Fergerson, R.W.; Hoffmann, G.W.; Milner, E.C.; Ray, L.; Amann, J.F.; Bonner, B.E.; McClelland, J.B.

1986-01-01

500 MeV p-arrow-right+p elastic and quasielastic, and p-arrow-right+n quasielastic, analyzing powers (A/sub y/) and spin-rotation-depolarization parameters (D/sub S//sub S/, D/sub S//sub L/, D/sub L//sub S/, D/sub L//sub L/, D/sub N//sub N/) were determined for center-of-momentum angular ranges 6.8 0 -55.4 0 (elastic) and 22.4 0 -55.4 0 (quasielastic); liquid hydrogen and deuterium targets were used. The p-arrow-right+p elastic and quasielastic results are in good agreement; both the p-arrow-right+p and p-arrow-right+n parameters are well described by current phase shift solutions

Recurring dominant-negative mutations in the AVP-NPII gene cause neurohypophyseal diabetes insipidus

Energy Technology Data Exchange (ETDEWEB)

Repaske, D.R. [Children`s Hospital Medical Center, Cincinnati, OH (United States); Phillips, J.A.; Krishnamani, M.R.S. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others

1994-09-01

Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is a familial form of arginine vasopressin (or antidiuretic hormone) deficiency that is usually manifest in early childhood with polyuria, polydipsia and an antidiuretic response to exogenous vasopressin or its analogs. The phenotype is postulated to arise from gliosis and depletion of the magnocellular neurons that produce vasopressin in the supraoptic and paraventricular nuclei of the hypothalamus. ADNDI is caused by heterozygosity for a variety of mutations in the AVP-NPII gene which encodes vasopressin, its carrier protein (NPII) and a glycoprotein (copeptin) of unknown function. These mutations include: (1) Ala 19{r_arrow}Thr (G279A) in AVP`s signal peptide, (2) Gly 17{r_arrow}Val (G1740T), (3) Pro 24{r_arrow}Leu (C1761T), (4) Gly 57{r_arrow}Ser (G1859A) and (5) del Glu 47({delta}AGG 1824-26), all of which occur in NPII. In characterizing the AVP-NPII mutations in five non-related ADNDI kindreds, we have detected two kindreds having mutation 1 (G279A), two having mutation 3 (C1761T) and one having mutation 4 (G1859A) without any other allelic changes being detected. Two of these recurring mutations (G279A and G1859A) are transitions that occur at CpG dinucleotides while the third (C1761T) does not. Interestingly, families with the same mutations differed in their ethnicity or in their affected AVP-NPII allele`s associated haplotype of closely linked DNA polymorphisms. Our data indicated that at least three of five known AVP-NPII mutations causing ADNDI tend to recur but the mechanisms by which these dominant-negative mutations cause variable or progressive expression of the ADNDI phenotype remain unclear.

Unconscious and out of control: subliminal priming is insensitive to observer expectations.

Science.gov (United States)

Cressman, Erin K; Lam, Melanie Y; Franks, Ian M; Enns, James T; Chua, Romeo

2013-09-01

We asked whether the influence of an invisible prime on movement is dependent on conscious movement expectations. Participants reached to a central target, which triggered a directional prime-mask arrow sequence. Participants were instructed that the visible arrows (masks) would most often signal a movement modification in a specific (biased) direction. Kinematic analyses revealed that responses to the visible mask were influenced by participants' intentional bias, as movements were fastest when the more probable mask was displayed. In addition, responses were influenced by the invisible prime without regard to its relationship to the more probable mask. Analysis of the time of initial trajectory modifications revealed that both primes influenced responses in a similar manner after accounting for participants' bias. These results imply that invisible stimuli automatically activate their associated responses and that unconscious priming of the motor system is insensitive to the conscious expectations of the participant making the pointing movements. Copyright © 2013 Elsevier Inc. All rights reserved.

Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: No cosegregation with severe hyperlipidemia

Energy Technology Data Exchange (ETDEWEB)

Maagdenberg, A.M.J.M. van den; Bruijn, I.H. de; Hofker, M.H.; Frants, R.R. (Leiden Univ. (Netherlands)); Knijff, P. de; Smelt, A.H.M.; Leuven, J.A.G.; van' t Hooft, F.; Assmann, G.; Havekes, L.M. (Univ. Hospital, Leiden (Netherlands)); Weng, Wei; Funke, H. (Westfalische Wilhelms-Universitaet, Muester (Germany))

1993-05-01

Assessment of the apolipoprotein E (apoE) phenotype by isoelectric focusing of both hyperlipidemic and normolipidemic individuals identified five new variants. All mutations were confined to the downstream part of the APOE gene by using denaturing gradient gel electrophoresis (DGGE). Sequence analysis revealed five new mutations causing unique amino acid substitutions in the carboxyl-terminal part of the protein containing the putative lipid-binding domain. Three hyperlipoproteinemic probands were carriers of the APOE*2(Va1236[r arrow]Glu) allele, the APOE*3(Cys112-Arg; Arg251[r arrow]Gly) allele, or the APOE*1(Arg158[r arrow]Cys; Leu252[r arrow]Glu) allele. DGGE of the region encoding the receptor-binding domain was useful for haplotyping the mutations at codons 112 and 158. Family studies failed to demonstrate cosegregation between the new mutations and severe hyperlipoproteinemia, although a number of carriers for the APOE*3(Cys112[r arrow]Arg; Arg251[r arrow]Gly) allele and the APOE*1(Arg158-Cys; Leu252[r arrow]Glu) allele expressed hypertriglyceridemia and/ or hypercholesterolemia. Two other mutant alleles, APOE*4[sup [minus

R&D Nuggets

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RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About &D Nuggets Database dropdown arrow Search Tag Cloud Browse Reports Database Help Finding Aids

The cosmological origin of time asymmetry

Energy Technology Data Exchange (ETDEWEB)

Castagnino, Mario [Instituto de Astronomia y Fisica del Espacio, Casilla de Correos 67, Sucursal 28, 1428 Buenos Aires (Argentina); Lara, Luis [Departamento de Fisica, Universidad Nacional de Rosario, Av. Pellegrini 250, 2000 Rosario (Argentina); Lombardi, Olimpia [CONICET - Universidad de Buenos Aires, Puan 470, 1406 Buenos Aires (Argentina)

2003-01-21

In this paper, we address the problem of the arrow of time from a cosmological point of view, rejecting the traditional entropic approach that defines the future direction of time as the direction of the entropy increase: from our perspective, the arrow of time has a global origin and it is an intrinsic, geometrical feature of spacetime. Time orientability and the existence of a cosmic time are necessary conditions for defining an arrow of time, which is manifested globally as the time asymmetry of the universe as a whole, and locally as a time-asymmetric energy flux. We also consider arrows of time of different origins (quantum, electromagnetic, thermodynamic, etc) showing that they can be non-conventionally defined only if the geometrical arrow is previously defined.

A new population record and conservation assessment of the Santa Marta Poison Arrow Frog Colostethus ruthveni Kaplan, 1997 (Anura: Dendrobatidae from Sierra Nevada de Santa Marta, Colombia

Directory of Open Access Journals (Sweden)

J.F.G. Maya

2011-03-01

Full Text Available Colombia possesses important amphibian species richness that is threatened by several factors. Here we report a new population of the Santa Marta Poison Arrow Frog Colostethus ruthveni, an endangered endemic species from Sierra Nevada de Santa Marta mountain range. During intensive surveys across Námaku Reserve, 22 C. ruthveni individuals (mean abundance 0.28 plus or minus 0.09 ind/km were observed along creeks between 737 and 923m above sea level near downtown Minca. This record represents a new locality for the species, increasing the number of known sites and expanding its extent of occurrence. We suggest the reassessment of the conservation status of the species from EN B1ab(iii to VU B1ab(iii, due to this and other recent findings. Currently, the species is present in three protected areas; this new record represents another reserve area where the species is distributed, ensuring the habitat and reducing some of its most important threats such as habitat loss and degradation from agricultural activities, logging, pollution and infrastructure development. This finding represents new critical information for the species and defines the need to understand the real status of its populations for future conservation strategies in the region.

Variable reflectivity signal mirrors and signal response measurements

International Nuclear Information System (INIS)

Vine, Glenn de; Shaddock, Daniel A; McClelland, David E

2002-01-01

Future gravitational wave detectors will include some form of signal mirror in order to alter the signal response of the device. We introduce interferometer configurations which utilize a variable reflectivity signal mirror allowing a tunable peak frequency and variable signal bandwidth. A detector configured with a Fabry-Perot cavity as the signal mirror is compared theoretically with one using a Michelson interferometer for a signal mirror. A system for the measurement of the interferometer signal responses is introduced. This technique is applied to a power-recycled Michelson interferometer with resonant sideband extraction. We present broadband measurements of the benchtop prototype's signal response for a range of signal cavity detunings. This technique is also applicable to most other gravitational wave detector configurations

Variable reflectivity signal mirrors and signal response measurements

CERN Document Server

Vine, G D; McClelland, D E

2002-01-01

Future gravitational wave detectors will include some form of signal mirror in order to alter the signal response of the device. We introduce interferometer configurations which utilize a variable reflectivity signal mirror allowing a tunable peak frequency and variable signal bandwidth. A detector configured with a Fabry-Perot cavity as the signal mirror is compared theoretically with one using a Michelson interferometer for a signal mirror. A system for the measurement of the interferometer signal responses is introduced. This technique is applied to a power-recycled Michelson interferometer with resonant sideband extraction. We present broadband measurements of the benchtop prototype's signal response for a range of signal cavity detunings. This technique is also applicable to most other gravitational wave detector configurations.

Macroencapsulation of mixed waste debris at the Hanford Nuclear Reservation -- Final project report by AST Environmental Services, LLC

International Nuclear Information System (INIS)

Baker, T.L.

1998-01-01

This report summarizes the results of a full-scale demonstration of a high density polyethylene (HDPE) package, manufactured by Arrow Construction, Inc. of Montgomery, Alabama. The HDPE package, called ARROW-PAK, was designed and patented by Arrow as both a method to macroencapsulation of radioactively contaminated lead and as an improved form of waste package for treatment and interim and final storage and/or disposal of drums of mixed waste. Mixed waste is waste that is radioactive, and meets the criteria established by the United States Environmental Protection Agency (US EPA) for a hazardous material. Results from previous testing conducted for the Department of Energy (DOE) at the Idaho National Engineering Laboratory in 1994 found that the ARROW-PAK fabrication process produces an HDPE package that passes all helium leak tests and drop tests, and is fabricated with materials impervious to the types of environmental factors encountered during the lifetime of the ARROW-PAK, estimated to be from 100 to 300 years. Arrow Construction, Inc. has successfully completed full-scale demonstration of its ARROW-PAK mixed waste macroencapsulation treatment unit at the DOE Hanford Site. This testing was conducted in accordance with Radiological Work Permit No. T-860, applicable project plans and procedures, and in close consultation with Waste Management Federal Services of Hanford, Inc.'s project management, health and safety, and quality assurance representatives. The ARROW-PAK field demonstration successfully treated 880 drums of mixed waste debris feedstock which were compacted and placed in 149 70-gallon overpack drums prior to macroencapsulation in accordance with the US EPA Alternate Debris Treatment Standards, 40 CFR 268.45. Based on all of the results, the ARROW-PAK process provides an effective treatment, storage and/or disposal option that compares favorably with current mixed waste management practices

Separate Mechanisms Recruited by Exogenous and Endogenous Spatial Cues: Evidence from a Spatial Stroop Paradigm

Science.gov (United States)

Funes, Maria Jesus; Lupianez, Juan; Milliken, Bruce

2007-01-01

The present experiments tested whether endogenous and exogenous cues produce separate effects on target processing. In Experiment 1, participants discriminated whether an arrow presented left or right of fixation pointed to the left or right. For 1 group, the arrow was preceded by a peripheral noninformative cue. For the other group, the arrow was…

[Analysis and research of brain-computer interface experiments for imaging left-right hands movement].

Science.gov (United States)

Wu, Yazhou; He, Qinghua; Huang, Hua; Zhang, Ling; Zhuo, Yu; Xie, Qi; Wu, Baoming

2008-10-01

This is a research carried out to explore a pragmatic way of BCI based imaging movement, i. e. to extract the feature of EEG for reflecting different thinking by searching suitable methods of signal extraction and recognition algorithm processing, to boost the recognition rate of communication for BCI system, and finally to establish a substantial theory and experimental support for BCI application. In this paper, different mental tasks for imaging left-right hands movement from 6 subjects were studied in three different time sections (hint keying at 2s, 1s and 0s after appearance of arrow). Then we used wavelet analysis and Feed-forward Back-propagation Neural Network (BP-NN) method for processing and analyzing the experimental data of off-line. Delay time delta t2, delta t1 and delta t0 for all subjects in the three different time sections were analyzed. There was significant difference between delta to and delta t2 or delta t1 (P0.05). The average results of recognition rate were 65%, 86.67% and 72%, respectively. There were obviously different features for imaging left-right hands movement about 0.5-1s before actual movement; these features displayed significant difference. We got higher recognition rate of communication under the hint keying at about 1s after the appearance of arrow. These showed the feasibility of using the feature signals extracted from the project as the external control signals for BCI system, and demon strated that the project provided new ideas and methods for feature extraction and classification of mental tasks for BCI.

Formalizing Arrow's theorem

Indian Academy of Sciences (India)

Institute for Computing and Information Sciences, Radboud University ..... group decision on the order of a and b by manipulating his or her preference for ...... by reducing the number of subsections and making my comments a bit more polite.

Memories of Reward and Nonreward Regulate the Extinction and Reacquisition of both Excitatory and Inhibitory Associations

Science.gov (United States)

Capaldi, E. J.; Martins, Ana P. G.; Altman, Meaghan

2009-01-01

arrow]US associations also survived The memories of the unconditioned stimulus (US) and its absence (No US), symbolized as S[superscript R] and S[superscript N], respectively, may be retrieved on US or No US trials giving rise to four types of associations, S[superscript R][right arrow]US, S[superscript R][right arrow]No US, S[superscript N][right…

A topos foundation for theories of physics: III. The representation of physical quantities with arrows δo(A):Σ lowbar →Rsccue lowbar

International Nuclear Information System (INIS)

Doering, A.; Isham, C. J.

2008-01-01

This paper is the third in a series whose goal is to develop a fundamentally new way of viewing theories of physics. Our basic contention is that constructing a theory of physics is equivalent to finding a representation in a topos of a certain formal language that is attached to the system. In Paper II, we studied the topos representations of the propositional language PL(S) for the case of quantum theory, and in the present paper we do the same thing for the, more extensive, local language L(S). One of the main achievements is to find a topos representation for self-adjoint operators. This involves showing that, for any physical quantity A, there is an arrow δ o (A):Σ lowbar →R sccue lowbar , where R sccue lowbar is the quantity-value object for this theory. The construction of δ o (A) is an extension of the daseinisation of projection operators that was discussed in Paper II. The object R sccue lowbar is a monoid object only in the topos, τ φ =Sets V(H) op , of the theory, and to enhance the applicability of the formalism, we apply to R sccue lowbar a topos analog of the Grothendieck extension of a monoid to a group. The resulting object, k(R sccue lowbar ), is an abelian group object in τ φ . We also discuss another candidate, R ↔ lowbar , for the quantity-value object. In this presheaf, both inner and outer daseinisations are used in a symmetric way. Finally, there is a brief discussion of the role of unitary operators in the quantum topos scheme

Transitions between neutral mesons in multiquark schemes

International Nuclear Information System (INIS)

Volkov, G.G.; Liparteliani, A.G.; Monich, V.A.; Nikitin, Y.P.

1981-01-01

A six-quark scheme based on the gauge group SU(2)/sub L/ x U(1) is used to obtain expressions for the amplitudes of the transitions K 0 bold-arrow-left-right K-bar 0 , D 0 bold-arrow-left-right D-bar 0 , B 0 bold-arrow-left-right B-bar 0 , B/sub S/ 0 bold-arrow-left-right B-bar/sub S/ 0 , T 0 bold-arrow-left-right T-bar 0 , and T/sub C/ 0 bold-arrow-left-right T-bar/sub C/ 0 for finite 4-momenta of the external lines of the Feynman box diagrams. An estimate is made of the degree of applicability of the approximation of vanishingly small 4-momenta of the valence quarks which form the neutral mesons such as the K 0 and K-bar 0 mesons. Constraints are found on the parameters of the unitary matrix of the weak charged currents for arbitrary values of the t-quark mass. Estimates are given of the numerical values of the mixing and CP-violation parameters for neutral systems such as the K 0 --K-bar 0 system

Electron-electron bound states in Maxwell-Chern-Simons-Proca QED{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Belich, H.; Helayel-Neto, J.A. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil)]|[Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil). Coordenacao de Teoria de Campos e Particulas]. E-mail: belich@cbpf.br; helayel@gft.ucp.br; Del Cima, O.M. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil)]. E-mail: delcima@gft.ucp.br; Ferreira, M.M. Jr. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil)]|[Maranhao Univ., Sao Luis, MA (Brazil). Dept. de Fisica]. E-mail: manojr@cbpf.br

2002-10-01

We start from a parity-breaking MCS QED{sub 3} model with spontaneous breaking of the gauge symmetry as a framework for evaluation of the electron-electron interaction potential and for attainment of numerical values for the e{sup -}e{sup -} - bound state. Three expressions (V{sub eff{down_arrow}}{sub {down_arrow}}, V{sub eff{down_arrow}}{sub {up_arrow}}, V{sub eff{down_arrow}}{sub {down_arrow}}) are obtained according to the polarization state of the scattered electrons. In an energy scale compatible with condensed matter electronic excitations, these potentials become degenerated. The resulting potential is implemented in the Schroedinger equation and the variational method is applied to carry out the electronic binding energy. The resulting binding energies in the scale of 10-100 meV and a correlation length in the scale of 10 - 30 Angstrom are possible indications that the MCS-QED{sub 3} model adopted may be suitable to address an eventual case of e{sup -}e{sup -} pairing in the presence of parity-symmetry breakdown. The data analyzed here suggest an energy scale of 10-100 meV to fix the breaking of the U(1)-symmetry. (author)

Rate constants of the equilibrium reactions SO⨪4 + HNO3 ⇄ HSO-4 + NO3 and SO⨪4 + NO-3 ⇄ SO2-4 + NO3

DEFF Research Database (Denmark)

Løgager, T.; Sehested, K.; Holcman, J.

1993-01-01

Rate constants of the following equilibrium reactions were determined by pulse radiolysis at high solute concentrations: SO4.- + HNO, half arrow right over half arrow left HSO4- + NO3. [k(f) = (2.7 +/- 0.5) x 10(6) M-1 s-1, k(r) = (5.6 +/- 1.0) x 10(3) M-1 s-1] and SO4.- + NO3- half arrow right...

Developing an Assessment, Monitoring, and Evaluation Framework for U.S. Department of Defense Security Cooperation

Science.gov (United States)

2016-09-01

Eileen  Cronin. They and their OSD and Joint Staff colleagues pro- vided important insights throughout our research. We also recognize the invaluable...independent review of EUCOM’s planning documents. The gray arrows indicate how elements of higher planning strata drive lower elements. The green arrows...activities and events, based on our indepen- dent review of PACOM’s planning documents. The gray arrows indi- 14 Interview with PACOM headquarters official

Mono-static GPR without transmitting anything for pavement damage inspection: interferometry by auto-correlation applied to mobile phone signals

Science.gov (United States)

Feld, R.; Slob, E. C.; Thorbecke, J.

2015-12-01

Creating virtual sources at locations where physical receivers have measured a response is known as seismic interferometry. A much appreciated benefit of interferometry is its independence of the actual source locations. The use of ambient noise as actual source is therefore not uncommon in this field. Ambient noise can be commercial noise, like for example mobile phone signals. For GPR this can be useful in cases where it is not possible to place a source, for instance when it is prohibited by laws and regulations. A mono-static GPR antenna can measure ambient noise. Interferometry by auto-correlation (AC) places a virtual source on this antenna's position, without actually transmitting anything. This can be used for pavement damage inspection. Earlier work showed very promising results with 2D numerical models of damaged pavement. 1D and 2D heterogeneities were compared, both modelled in a 2D pavement world. In a 1D heterogeneous model energy leaks away to the sides, whereas in a 2D heterogeneous model rays can reflect and therefore still add to the signal reconstruction (see illustration). In the first case the amount of stationary points is strictly limited, while in the other case the amount of stationary points is very large. We extend these models to a 3D world and optimise an experimental configuration. The illustration originates from the journal article under submission 'Non-destructive pavement damage inspection by mono-static GPR without transmitting anything' by R. Feld, E.C. Slob, and J.W. Thorbecke. (a) 2D heterogeneous pavement model with three irregular-shaped misalignments between the base and subbase layer (marked by arrows). Mono-antenna B-scan positions are shown schematically. (b) Ideal output: a real source at the receiver's position. The difference w.r.t. the trace found in the middle is shown. (c) AC output: a virtual source at the receiver's position. There is a clear overlap with the ideal output.

Signaling aggression.

Science.gov (United States)

van Staaden, Moira J; Searcy, William A; Hanlon, Roger T

2011-01-01

From psychological and sociological standpoints, aggression is regarded as intentional behavior aimed at inflicting pain and manifested by hostility and attacking behaviors. In contrast, biologists define aggression as behavior associated with attack or escalation toward attack, omitting any stipulation about intentions and goals. Certain animal signals are strongly associated with escalation toward attack and have the same function as physical attack in intimidating opponents and winning contests, and ethologists therefore consider them an integral part of aggressive behavior. Aggressive signals have been molded by evolution to make them ever more effective in mediating interactions between the contestants. Early theoretical analyses of aggressive signaling suggested that signals could never be honest about fighting ability or aggressive intentions because weak individuals would exaggerate such signals whenever they were effective in influencing the behavior of opponents. More recent game theory models, however, demonstrate that given the right costs and constraints, aggressive signals are both reliable about strength and intentions and effective in influencing contest outcomes. Here, we review the role of signaling in lieu of physical violence, considering threat displays from an ethological perspective as an adaptive outcome of evolutionary selection pressures. Fighting prowess is conveyed by performance signals whose production is constrained by physical ability and thus limited to just some individuals, whereas aggressive intent is encoded in strategic signals that all signalers are able to produce. We illustrate recent advances in the study of aggressive signaling with case studies of charismatic taxa that employ a range of sensory modalities, viz. visual and chemical signaling in cephalopod behavior, and indicators of aggressive intent in the territorial calls of songbirds. Copyright © 2011 Elsevier Inc. All rights reserved.

Functional network of glycan-related molecules: Glyco-Net in Glycoconjugate Data Bank

Directory of Open Access Journals (Sweden)

Miura Nobuaki

2010-06-01

Full Text Available Abstract Background Glycans are involved in a wide range of biological process, and they play an essential role in functions such as cell differentiation, cell adhesion, pathogen-host recognition, toxin-receptor interactions, signal transduction, cancer metastasis, and immune responses. Elucidating pathways related to post-translational modifications (PTMs such as glycosylation are of growing importance in post-genome science and technology. Graphical networks describing the relationships among glycan-related molecules, including genes, proteins, lipids and various biological events are considered extremely valuable and convenient tools for the systematic investigation of PTMs. However, there is no database which dynamically draws functional networks related to glycans. Description We have created a database called Glyco-Net http://www.glycoconjugate.jp/functions/, with many binary relationships among glycan-related molecules. Using search results, we can dynamically draw figures of the functional relationships among these components with nodes and arrows. A certain molecule or event corresponds to a node in the network figures, and the relationship between the molecule and the event are indicated by arrows. Since all components are treated equally, an arrow is also a node. Conclusions In this paper, we describe our new database, Glyco-Net, which is the first database to dynamically show networks of the functional profiles of glycan related molecules. The graphical networks will assist in the understanding of the role of the PTMs. In addition, since various kinds of bio-objects such as genes, proteins, and inhibitors are equally treated in Glyco-Net, we can obtain a large amount of information on the PTMs.

Robust power detector for wideband signals among many single tone signals

Science.gov (United States)

Musgrove, Cameron H.; Thompson, Douglas

2018-03-06

Various technologies for isolating a signal of interest from signals received contemporaneously by an antenna are described herein. A time period for which a signal of interest is present in a second signal can be identified based upon ratios of values of the second signal to the mean value of the second signal. When the ratio of the value of the second signal at a particular time to the mean of the second signal exceeds a threshold value, the signal of interest is considered to be present in the second signal.

Salicylic acid signaling inhibits apoplastic reactive oxygen species signaling.

Science.gov (United States)

Xu, Enjun; Brosché, Mikael

2014-06-04

Reactive oxygen species (ROS) are used by plants as signaling molecules during stress and development. Given the amount of possible challenges a plant face from their environment, plants need to activate and prioritize between potentially conflicting defense signaling pathways. Until recently, most studies on signal interactions have focused on phytohormone interaction, such as the antagonistic relationship between salicylic acid (SA)-jasmonic acid and cytokinin-auxin. In this study, we report an antagonistic interaction between SA signaling and apoplastic ROS signaling. Treatment with ozone (O3) leads to a ROS burst in the apoplast and induces extensive changes in gene expression and elevation of defense hormones. However, Arabidopsis thaliana dnd1 (defense no death1) exhibited an attenuated response to O3. In addition, the dnd1 mutant displayed constitutive expression of defense genes and spontaneous cell death. To determine the exact process which blocks the apoplastic ROS signaling, double and triple mutants involved in various signaling pathway were generated in dnd1 background. Simultaneous elimination of SA-dependent and SA-independent signaling components from dnd1 restored its responsiveness to O3. Conversely, pre-treatment of plants with SA or using mutants that constitutively activate SA signaling led to an attenuation of changes in gene expression elicited by O3. Based upon these findings, we conclude that plants are able to prioritize the response between ROS and SA via an antagonistic action of SA and SA signaling on apoplastic ROS signaling.

Reviews Toy: Air swimmers Book: Their Arrows will Darken the Sun: The Evolution and Science of Ballistics Book: Physics Experiments for your Bag Book: Quantum Physics for Poets Equipment: SEP colour wheel kit Equipment: SEP colour mixing kit Software: USB DrDAQ App: iHandy Level Equipment: Photonics Explorer kit Web Watch

Science.gov (United States)

2012-01-01

WE RECOMMEND Air swimmers Helium balloon swims like a fish Their Arrows will Darken the Sun: The Evolution and Science of Ballistics Ballistics book hits the spot Physics Experiments for your Bag Handy experiments for your lessons Quantum Physics for Poets Book shows the economic importance of physics SEP colour wheel kit Wheels investigate colour theory SEP colour mixing kit Cheap colour mixing kit uses red, green and blue LEDs iHandy Level iPhone app superbly measures angles Photonics Explorer kit Free optics kit given to schools WORTH A LOOK DrDAQ DrDAQ software gets an upgrade WEB WATCH Websites show range of physics

FijiWingsPolarity: An open source toolkit for semi-automated detection of cell polarity.

Science.gov (United States)

Dobens, Leonard L; Shipman, Anna; Axelrod, Jeffrey D

2018-01-02

Epithelial cells are defined by apical-basal and planar cell polarity (PCP) signaling, the latter of which establishes an orthogonal plane of polarity in the epithelial sheet. PCP signaling is required for normal cell migration, differentiation, stem cell generation and tissue repair, and defects in PCP have been associated with developmental abnormalities, neuropathologies and cancers. While the molecular mechanism of PCP is incompletely understood, the deepest insights have come from Drosophila, where PCP is manifest in hairs and bristles across the adult cuticle and organization of the ommatidia in the eye. Fly wing cells are marked by actin-rich trichome structures produced at the distal edge of each cell in the developing wing epithelium and in a mature wing the trichomes orient collectively in the distal direction. Genetic screens have identified key PCP signaling pathway components that disrupt trichome orientation, which has been measured manually in a tedious and error prone process. Here we describe a set of image processing and pattern-recognition macros that can quantify trichome arrangements in micrographs and mark these directly by color, arrow or colored arrow to indicate trichome location, length and orientation. Nearest neighbor calculations are made to exploit local differences in orientation to better and more reliably detect and highlight local defects in trichome polarity. We demonstrate the use of these tools on trichomes in adult wing preps and on actin-rich developing trichomes in pupal wing epithelia stained with phalloidin. FijiWingsPolarity is freely available and will be of interest to a broad community of fly geneticists studying the effect of gene function on PCP.

A new look at the ventral nerve centre of Sagitta: implications for the phylogenetic position of Chaetognatha (arrow worms and the evolution of the bilaterian nervous system

Directory of Open Access Journals (Sweden)

Müller Carsten HG

2007-05-01

Full Text Available Abstract Background The Chaetognatha (arrow worms are a group of marine carnivores whose phylogenetic relationships are still vigorously debated. Molecular studies have as yet failed to come up with a stable hypothesis on their phylogenetic position. In a wide range of metazoans, the nervous system has proven to provide a wealth of characters for analysing phylogenetic relationships (neurophylogeny. Therefore, in the present study we explored the structure of the ventral nerve centre ("ventral ganglion" in Sagitta setosa with a set of histochemical and immunohistochemical markers. Results In specimens that were immunolabeled for acetylated-alpha tubulin the ventral nerve centre appeared to be a condensed continuation of the peripheral intraepidermal nerve plexus. Yet, synapsin immunolocalization showed that the ventral nerve centre is organized into a highly ordered array of ca. 80 serially arranged microcompartments. Immunohistochemistry against RFamide revealed a set of serially arranged individually identifiable neurons in the ventral nerve centre that we charted in detail. Conclusion The new information on the structure of the chaetognath nervous system is compared to previous descriptions of the ventral nerve centre which are critically evaluated. Our findings are discussed with regard to the debate on nervous system organisation in the last common bilaterian ancestor and with regard to the phylogenetic affinities of this Chaetognatha. We suggest to place the Chaetognatha within the Protostomia and argue against hypotheses which propose a deuterostome affinity of Chaetognatha or a sister-group relationship to all other Bilateria.

Polarization enhancement in (d)over-right-arrow((p)over-right-arrow,(n)over-right-arrow)He-2 reaction : nuclear teleportation

NARCIS (Netherlands)

Hamieh, S

2004-01-01

I show that an experimental technique used in nuclear physics may be successfully applied to quantum teleportation (QT) of spin states of massive matter. A new non-local physical effect, the 'quantum-teleportation effect', is discovered for the nuclear polarization measurement. Enhancement of the

Lifshitz singularities in random harmonic chains: periodic amplitudes near the band edge and near special frequencies

International Nuclear Information System (INIS)

Nieuwenhuizen, T.M.; Luck, J.M.

1987-01-01

The authors give a complete description of the scaling behavior of the integrated density of states of random harmonic chains with random masses near the band edge omega/sub max/ and near special frequencies omega/sub s/. There are four different situations: omega upward arrow omega/sub max/, omega upward arrow omega/sub s/, omega upward arrow omega/sub s/ (critical case), omega upward arrow omega/sub s/ (general case). Their analytic results have the form of infinite sums involving Fourier coefficients of the scaling behavior of the Dyson-Schmidt function at the special frequency or the band edge. Binary mass distributions are considered in detail in the limit of a small fraction rho of light masses. Their predictions are compared with extensive numerical data

Optimal Signal Quality Index for Photoplethysmogram Signals

Directory of Open Access Journals (Sweden)

Mohamed Elgendi

2016-09-01

Full Text Available A photoplethysmogram (PPG is a noninvasive circulatory signal related to the pulsatile volume of blood in tissue and is typically collected by pulse oximeters. PPG signals collected via mobile devices are prone to artifacts that negatively impact measurement accuracy, which can lead to a significant number of misleading diagnoses. Given the rapidly increased use of mobile devices to collect PPG signals, developing an optimal signal quality index (SQI is essential to classify the signal quality from these devices. Eight SQIs were developed and tested based on: perfusion, kurtosis, skewness, relative power, non-stationarity, zero crossing, entropy, and the matching of systolic wave detectors. Two independent annotators annotated all PPG data (106 recordings, 60 s each and a third expert conducted the adjudication of differences. The independent annotators labeled each PPG signal with one of the following labels: excellent, acceptable or unfit for diagnosis. All indices were compared using Mahalanobis distance, linear discriminant analysis, quadratic discriminant analysis, and support vector machine with leave-one-out cross-validation. The skewness index outperformed the other seven indices in differentiating between excellent PPG and acceptable, acceptable combined with unfit, and unfit recordings, with overall F 1 scores of 86.0%, 87.2%, and 79.1%, respectively.

Optimal Signal Quality Index for Photoplethysmogram Signals.

Science.gov (United States)

Elgendi, Mohamed

2016-09-22

A photoplethysmogram (PPG) is a noninvasive circulatory signal related to the pulsatile volume of blood in tissue and is typically collected by pulse oximeters. PPG signals collected via mobile devices are prone to artifacts that negatively impact measurement accuracy, which can lead to a significant number of misleading diagnoses. Given the rapidly increased use of mobile devices to collect PPG signals, developing an optimal signal quality index (SQI) is essential to classify the signal quality from these devices. Eight SQIs were developed and tested based on: perfusion, kurtosis, skewness, relative power, non-stationarity, zero crossing, entropy, and the matching of systolic wave detectors. Two independent annotators annotated all PPG data (106 recordings, 60 s each) and a third expert conducted the adjudication of differences. The independent annotators labeled each PPG signal with one of the following labels: excellent, acceptable or unfit for diagnosis. All indices were compared using Mahalanobis distance, linear discriminant analysis, quadratic discriminant analysis, and support vector machine with leave-one-out cross-validation. The skewness index outperformed the other seven indices in differentiating between excellent PPG and acceptable, acceptable combined with unfit, and unfit recordings, with overall F 1 scores of 86.0%, 87.2%, and 79.1%, respectively.

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African Journals Online (AJOL)

Dr Olaleye

maturation stages, white arrow indicates lumen, black arrow indicates sloughed germ cells within the seminiferous tubule ... Oboh and Rocha, 2007; Oseni and Okoye, 2013; Adetutu et ..... Sthiannopkao Arsenic geochemistry of groundwater.

Signal Words

Science.gov (United States)

SIGNAL WORDS TOPIC FACT SHEET NPIC fact sheets are designed to answer questions that are commonly asked by the ... making decisions about pesticide use. What are Signal Words? Signal words are found on pesticide product labels, ...

Investigation of Semileptonic {ital B} Meson Decays to {ital p} -Wave Charm Mesons

Energy Technology Data Exchange (ETDEWEB)

Anastassov, A.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Glenn, S.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Savinov, V.; Ugolini, D.; Wang, R.; Zhou, X. [Stanford Linear Accelerator Center, Stanford University, Stanford, California 94309 (United States); Coan, T.E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; Stroynowski, R.; Volobouev, I.; Ye, J. [Southern Methodist University, Dallas, Texas 75275 (United States); Artuso, M.; Efimov, A.; Goldberg, M.; He, D.; Kopp, S.; Moneti, G.C.; Mountain, R.; Schuh, S.; Skwarnicki, T.; Stone, S.; Viehhauser, G.; Xing, X. [Syracuse University, Syracuse, New York 13244 (United States); Bartelt, J.; Csorna, S.E.; Jain, V.; McLean, K.W.; Marka, S. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Godang, R.; Kinoshita, K.; Lai, I.C.; Pomianowski, P.; Schrenk, S. [Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L.P.; Zhou, G.J. [Wayne State University, Detroit, Michigan 48202 (United States); Barish, B.; Chadha, M.; Chan, S.; Eigen, G.; Miller, J.S.; OGrady, C.; Schmidtler, M.; Urheim, J.; Weinstein, A.J.; Wuerthwein, F. [California Institute of Technology, Pasadena, California 91125 (United States); Bliss, D.W.; Masek, G.; Paar, H.P.; Prell, S.; Sharma, V. and others

1998-05-01

We have studied semileptonic B meson decays with a p -wave charm meson in the final state using 3.29{times}10{sup 6} B{ovr B} events collected with the CLEOII detector at the Cornell Electron-Positron Storage Ring. We find a value for the exclusive semileptonic product branching fraction B(B{sup {minus}}{r_arrow}D{sup 0}{sub 1} {ell}{sup {minus}}{ovr {nu}}{sub {ell}}) B(D{sup 0}{sub 1}{r_arrow}D{sup {asterisk}+} {pi}{sup {minus}})=(0.373{plus_minus}0.085{plus_minus} 0.052{plus_minus}0.024){percent} and an upper limit for B(B{sup {minus}}{r_arrow}D{sup {asterisk}0}{sub 2} {ell}{sup {minus}}{ovr {nu}}{sub {ell}}) B(D{sup {asterisk}0}{sub 2}{r_arrow}D{sup {asterisk}+ }{pi}{sup {minus}}){lt}0.16{percent} (90{percent} C.L.). Furthermore, we present the first measurement of the q{sup 2} spectrum for B{sup {minus}}{r_arrow}D{sup 0}{sub 1}{ell}{sup {minus}} {ovr {nu}}{sub {ell}} . {copyright} {ital 1998} {ital The American Physical Society}

77 FR 61753 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2012-10-11

.... 20121302 G Arrow Electronics. Inc.; John F. Baker (Micro Electronics, Inc.); Arrow Electronics, Inc. 20121303 G Wind Point Partners L.P.; Mistral Equity Partners, LP; Wind Point Partners VII-A, L.P. 20121307...

Spinal Cord Injury 101

Medline Plus

Full Text Available ... spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can we expect stem-cell treatments to become available for spinal cord injuries? ...

Achilles' death: anatomical considerations regarding the most famous trauma of the Trojan War.

Science.gov (United States)

Anagnostopoulou, Sophia; Mavridis, Ioannis

2013-03-01

In Greek mythology, Achilles was a hero of the Trojan War, the central character and greatest warrior of Homer's Iliad. As Achilles died because of a small wound on his heel, the term "Achilles' heel" has come to mean a person's principal weakness. But is the human heel a really vulnerable part of our body? Could a non-poisonous arrow have caused Achilles' death? Should an arrow be necessarily poisonous in order to cause a lethal heel would? The purpose of this effort is to explain, from an anatomic point of view, how Achilles heel wounding could have led to his death. The Achilles tendon is the strongest, largest and thickest tendon in the human body and plays an important role in the biomechanics of the lower extremity. The blood supply of the tendon is from the peroneal and posterior tibial arteries. It is quite likely that the arrow which killed Achilles was poisoned. This supposition could be of course enough to cause his death. In case the arrow was not poisoned a rupture of the posterior tibial artery by the arrow could have caused a bleeding, but it seems unlikely for such a bleeding to be lethal. Moreover, a combination of these two theories could have also taken place, i.e. a poisoned arrow traumatizing the posterior tibial artery and hence causing rapid diffusion of the poison as well as bleeding. Furthermore, infectious and/or immunologic bases regarding Achilles' death could be considered. In our opinion, a poisoned arrow was probably the crucial factor leading to the famous inglorious death of this famous glorious Homeric hero.

Spinal Cord Injury 101

Medline Plus

Full Text Available ... of spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can we expect stem-cell treatments to become available for spinal cord injuries? ...

Sex and Fertility After SCI

Medline Plus

Full Text Available ... spinal cord injury? play_arrow How is sexual function in women affected by a spinal cord injury? play_arrow How is sexual function in men affected by a spinal cord injury ? ...

Preventing Pressure Sores

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Full Text Available ... increased? play_arrow What do family members and caregivers need to know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure sores? play_ ...

Detection of Noise in Composite Step Signal Pattern by Visualizing Signal Waveforms

Directory of Open Access Journals (Sweden)

Chaman Verma

2018-03-01

Full Text Available The Step Composite Signals is the combination of vital informative signals that are compressed and coded to produce a predefined test image on a display device. It carries the desired sequence of information from source to destination. This information may be transmitted as digital signal, video information or data signal required as an input for the destination module. For testing of display panels, Composite Test Signals are the most important attribute of test signal transmission system. In the current research paper we present an approach for the noise detection in Composite Step Signal by analysing Composite Step Signal waveforms. The analysis of the signal waveforms reveals that the noise affected components of the signal and subsequently noise reduction process is initiated which targets noisy signal component only. Thus the quality of signal is not compromised during noise reduction process.

ACHP | Tribal Historic Preservation Officers

Science.gov (United States)

preservation of significant historic properties. Those functions include identifying and maintaining Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications Search skip specific nav links Home arrow Historic Preservation Programs & Officers arrow THPOs

Multimodal signal variation in space and time : how important is matching a signal with its signaler?

OpenAIRE

Taylor, Ryan C.; Klein, Barrett; Stein, Joey; Ryan, Michael J.

2011-01-01

Multimodal signals (acoustic+visual) are known to be used by many anuran amphibians during courtship displays. The relative degree to which each signal component influences female mate choice, however, remains poorly understood. In this study we used a robotic frog with an inflating vocal sac and acoustic playbacks to document responses of female túngara frogs to unimodal signal components (acoustic and visual). We then tested female responses to a synchronous multimodal signal. Finally, we t...

Preventing Pressure Sores

Science.gov (United States)

... and how can it be increased? play_arrow What do family members and caregivers need to know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure sores? play_ ...

Spinal Cord Injury 101

Medline Plus

Full Text Available ... arrow What is the “Spinal Cord Injury Model Systems” program? play_arrow ... recommend or endorse health care products or services, or control the information found on external websites. The Hill Foundation is ...

Global set of quadrupole deformation parameters for even-even nuclei

International Nuclear Information System (INIS)

Raman, S.; Nestor, C.W. Jr.

1986-01-01

A compilation of experimental results has been completed for the reduced electric quadrupole transition probability [B(E2)up arrow] between the 0 + ground state and the first 2 + state in even-even nuclei. This compilation together with certain simple relationships noted by other authors can be used to make reasonable predictions of unmeasured B(E2)up arrow values. The quadrupole deformation parameter β 2 immediately follows, because β 2 is proportional to [B(E2)up arrow]/sup 1/2/. 8 refs., 7 figs

Level Scheme of {sup 223}Fr; Estudio del esquema de niveles del {sup 223}Fr

Energy Technology Data Exchange (ETDEWEB)

Gaeta, R; Gonzalez, L; Roldan, C

1972-07-01

A study has been made of the decay of {sup 227}Ac at levels of {sub 223}Fr, means of alpha Spectrometers of Si barrier detector and gamma Spectrometers of Ge(Li). The rotational bands 1/2-(541 {down_arrow}), 1/2-(530 {up_arrow}) and 3/2-(532 {down_arrow}) have been identified, as well as two octupolar bands associated with the fundamental one. The results obtained indicate that the unified model is applicable in this intermediate zone of the nuclide chart. (Author) 150 refs.

Reconstruction of action potential of repolarization in patients with congenital long-QT syndrome

International Nuclear Information System (INIS)

Kandori, Akihiko; Shimizu, Wataru; Yokokawa, Miki; Kamakura, Shiro; Miyatake, Kunio; Murakami, Masahiro; Miyashita, Tsuyoshi; Ogata, Kuniomi; Tsukada, Keiji

2004-01-01

A method for reconstructing an action potential during the repolarization period was developed. This method uses a current distribution-plotted as a current-arrow map (CAM)-calculated using magnetocardiogram (MCG) signals. The current arrows are summarized during the QRS complex period and subtracted during the ST-T wave period in order to reconstruct the action-potential waveform. To ensure the similarity between a real action potential and the reconstructed action potential using CAM, a monophasic action potential (MAP) and an MCG of the same patient with type-I long-QT syndrome were measured. Although the MAP had one notch that was associated with early afterdepolarization (EAD), the reconstructed action potential had two large and small notches. The small notch timing agreed with the occurrence of the EAD in the MAP. On the other hand, the initiation time of an abnormal current distribution coincides with the appearance timing of the first large notch, and its end time coincides with that of the second small notch. These results suggest that a simple reconstruction method using a CAM based on MCG data can provide a similar action-potential waveform to a MAP waveform without having to introduce a catheter

Signal detection

International Nuclear Information System (INIS)

Tholomier, M.

1985-01-01

In a scanning electron microscope, whatever is the measured signal, the same set is found: incident beam, sample, signal detection, signal amplification. The resulting signal is used to control the spot luminosity with the observer cathodoscope. This is synchronized with the beam scanning on the sample; on the cathodoscope, the image in secondary electrons, backscattered electrons,... of the sample surface is reconstituted. The best compromise must be found between a register time low enough to remove eventual variations (under the incident beam) of the nature of the observed phenomenon, and a good spatial resolution of the image and a signal-to-noise ratio high enough. The noise is one of the basic limitations of the scanning electron microscope performance. The whose measurement line must be optimized to reduce it [fr

Spinal Cord Injury 101

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Basics of SCI Rehabilitation

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Spinal Cord Injury 101

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Spinal Cord Injury 101

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Sex and Fertility After SCI

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Sex and Fertility After SCI

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Strategic and Market Analysis | Bioenergy | NREL

Science.gov (United States)

bioeconomy. Photo of three pieces of laboratory glassware; one contains a blue liquid and one is half filled has six arrows pointing right to a blue box labeled SELL and there are six arrows leaving SELL labeled

Basics of SCI Rehabilitation

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Spinal Cord Injury 101

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Spinal Cord Injury 101

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Full Text Available ... Cord Injury Allen Heinemann, PhD How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal ... injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a ...

Basics of SCI Rehabilitation

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Spinal Cord Injury 101

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Preventing Pressure Sores

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Spinal Cord Injury 101

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Basics of SCI Rehabilitation

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Basics of SCI Rehabilitation

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Spinal Cord Injury 101

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Sex and Fertility After SCI

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Human cortical activity evoked by contextual processing in attentional orienting.

Science.gov (United States)

Zhao, Shuo; Li, Chunlin; Uono, Shota; Yoshimura, Sayaka; Toichi, Motomi

2017-06-07

The ability to assess another person's direction of attention is paramount in social communication, many studies have reported a similar pattern between gaze and arrow cues in attention orienting. Neuroimaging research has also demonstrated no qualitative differences in attention to gaze and arrow cues. However, these studies were implemented under simple experiment conditions. Researchers have highlighted the importance of contextual processing (i.e., the semantic congruence between cue and target) in attentional orienting, showing that attentional orienting by social gaze or arrow cues could be modulated through contextual processing. Here, we examine the neural activity of attentional orienting by gaze and arrow cues in response to contextual processing using functional magnetic resonance imaging. The results demonstrated that the influence of neural activity through contextual processing to attentional orienting occurred under invalid conditions (when the cue and target were incongruent versus congruent) in the ventral frontoparietal network, although we did not identify any differences in the neural substrates of attentional orienting in contextual processing between gaze and arrow cues. These results support behavioural data of attentional orienting modulated by contextual processing based on the neurocognitive architecture.

Search for Orbitally Excited B Mesons in Semileptonic B Decays in pbar p Collisions at √s = 1.8 TeV.

Science.gov (United States)

Vučinić, Dejan

1997-04-01

We present a measurement of the production rate of orbitally excited (L=1) states of B mesons (B^**) in a 110 pb-1 sample of pbar p collisions collected by the CDF detector during the 1992-95 data-taking period. Observed pions from the decay B^**arrowπ^± B can be used to determine the flavor of B mesons at the time of production. The B decay modes used are B^-arrowbarνl^- D^0X, D^0arrow K^-π^+ bar B^0arrowbarνl^- D^+X, D^+arrow K^-π^+π^+ and bar B^0arrowbarνl^- D^*+X, D^*+arrow π^+D^0, D^0arrow K^-π^+ or K^-π^+π^-π^+. \\$^*We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Science and Culture of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; and the A. P. Sloan Foundation.

Digital signal processing the Tevatron BPM signals

International Nuclear Information System (INIS)

Cancelo, G.; James, E.; Wolbers, S.

2005-01-01

The Beam Position Monitor (TeV BPM) readout system at Fermilab's Tevatron has been updated and is currently being commissioned. The new BPMs use new analog and digital hardware to achieve better beam position measurement resolution. The new system reads signals from both ends of the existing directional stripline pickups to provide simultaneous proton and antiproton measurements. The signals provided by the two ends of the BPM pickups are processed by analog band-pass filters and sampled by 14-bit ADCs at 74.3MHz. A crucial part of this work has been the design of digital filters that process the signal. This paper describes the digital processing and estimation techniques used to optimize the beam position measurement. The BPM electronics must operate in narrow-band and wide-band modes to enable measurements of closed-orbit and turn-by-turn positions. The filtering and timing conditions of the signals are tuned accordingly for the operational modes. The analysis and the optimized result for each mode are presented

Development of Ultrasound to Measure In-Vivo Dynamic Cervical Spine Intervertebral Disc Mechanics

Science.gov (United States)

2016-01-01

D)- (F) Figure 5. C4-C5 FSU compression and re-expansion during the jump tests. The amplitude of FSU motion is illustrated as double arrow...minimum and maximum displacements, was shown as double arrow in Figure 5. Mean of the amplitudes (mean length of double arrows) over time, is used to...HS-823 31 F 138 C2-C3 3.85 232 4 Avg 54 92.6 4.8 354 Results: The piston stroke i.e. the displacement of the piston due to 150N load

Preventing Pressure Sores

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Full Text Available ... and how can it be increased? play_arrow What do family members and caregivers need to know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure sores? play_ ...

Membrane Trafficking and Vesicle Fusion

Indian Academy of Sciences (India)

IAS Admin

protein and the data can be cor- related with cellular .... these mutant cells under the electron microscope and found a large number of ... trans-Golgi network and early ..... Arrows represent the flow of membrane traffic: black arrows – antero-.

A G {r_arrow} A transition at position IVS-11 +1 of the HEX A {alpha}-chain gene in a non-Ashkenazic Mexican Tay-Sachs infant

Energy Technology Data Exchange (ETDEWEB)

Miranda, S.R.P.; Gwon, S.; DeGasperi, R. [New York Univ. Medical Center, NY (United States)] [and others

1994-09-01

Tay-Sachs disease (TSD) is an autosomal recessive storage disorder caused by a deficiency of the lysosomal enzyme, {beta}-N-acetylhexosaminidase A (Hex A), a heteropolymer composed of two polypeptides, {alpha} and {beta}. Mutations in the {alpha}-chain gene render the enzyme defective, resulting in the accumulation of g{sub m2} ganglioside in the nervous system. Deficiency of Hex A was detected in a non-Ashkenazic girl of Mexican origin indicating infantile onset of TSD. Molecular investigation of the {alpha}-chain gene excluded the typical Ashkenazic 4 bp insertion in the exon 11 and the intron 12 splice-junction mutations by Hae III and Dde I restriction analysis, respectively. Single strand conformation polymorphism (SSCP) analysis showed a different pattern in the sample where exon 11 and flanking regions were amplified in the patient DNA as compared to the migration of control DNA. Sequencing of PCR amplified genomic DNA containing exon 11 and flanking intronic regions showed a single base substitution (G {r_arrow} A) at position IVS-11 +1. This mutation creates a recognition site for the restriction enzyme Mbo II. Digestion of exon 11 and flanking regions with Mbo II demonstrated homozygosity of the patient for this mutation and heterozygosity in the mother. mRNA from cultured fibroblasts obtained from a normal control and from the propositus was reverse transcribed. The cDNAs coding for Hex A {alpha}-chain were amplified in four overlapping fragments. In the patient sample it was not possible to amplify the fragment containing the exon 11/intron 11 junction, indicating that this mutation alters normal RNA processing of the Hex A pre-mRNA resulting in the deficiency of Hex A activity.

Transient-Switch-Signal Suppressor

Science.gov (United States)

Bozeman, Richard J., Jr.

1995-01-01

Circuit delays transmission of switch-opening or switch-closing signal until after preset suppression time. Used to prevent transmission of undesired momentary switch signal. Basic mode of operation simple. Beginning of switch signal initiates timing sequence. If switch signal persists after preset suppression time, circuit transmits switch signal to external circuitry. If switch signal no longer present after suppression time, switch signal deemed transient, and circuit does not pass signal on to external circuitry, as though no transient switch signal. Suppression time preset at value large enough to allow for damping of underlying pressure wave or other mechanical transient.

Assessment of Geographical Variation in the Respiratory Toxicity of Desert Dust Particles

Science.gov (United States)

2013-01-01

dense nucleolus (n). There is close contact between the cells (arrowhead). The cytoplasm has many lamellar bodies – small, spherical, membrane-bound...osmiophilic, lamellar structures that contain phospholipid. Note the intact nuclear membrane (white arrow) and nucleolus (black arrow) and several

Fast digitizing and digital signal processing of detector signals

International Nuclear Information System (INIS)

Hannaske, Roland

2008-01-01

A fast-digitizer data acquisition system recently installed at the neutron time-of-flight experiment nELBE, which is located at the superconducting electron accelerator ELBE of Forschungszentrum Dresden-Rossendorf, is tested with two different detector types. Preamplifier signals from a high-purity germanium detector are digitized, stored and finally processed. For a precise determination of the energy of the detected radiation, the moving-window deconvolution algorithm is used to compensate the ballistic deficit and different shaping algorithms are applied. The energy resolution is determined in an experiment with γ-rays from a 22 Na source and is compared to the energy resolution achieved with analogously processed signals. On the other hand, signals from the photomultipliers of barium fluoride and plastic scintillation detectors are digitized. These signals have risetimes of a few nanoseconds only. The moment of interaction of the radiation with the detector is determined by methods of digital signal processing. Therefore, different timing algorithms are implemented and tested with data from an experiment at nELBE. The time resolutions achieved with these algorithms are compared to each other as well as to reference values coming from analog signal processing. In addition to these experiments, some properties of the digitizing hardware are measured and a program for the analysis of stored, digitized data is developed. The analysis of the signals shows that the energy resolution achieved with the 10-bit digitizer system used here is not competitive to a 14-bit peak-sensing ADC, although the ballistic deficit can be fully corrected. However, digital methods give better result in sub-ns timing than analog signal processing. (orig.)

Second-hand signals

DEFF Research Database (Denmark)

Bergenholtz, Carsten

2014-01-01

Studies of signaling theory have traditionally focused on the dyadic link between the sender and receiver of the signal. Within a science‐based perspective this framing has led scholars to investigate how patents and publications of firms function as signals. I explore another important type...... used by various agents in their search for and assessment of products and firms. I conclude by arguing how this second‐hand nature of signals goes beyond a simple dyadic focus on senders and receivers of signals, and thus elucidates the more complex interrelations of the various types of agents...

Signal-BNF: A Bayesian Network Fusing Approach to Predict Signal Peptides

Directory of Open Access Journals (Sweden)

Zhi Zheng

2012-01-01

Full Text Available A signal peptide is a short peptide chain that directs the transport of a protein and has become the crucial vehicle in finding new drugs or reprogramming cells for gene therapy. As the avalanche of new protein sequences generated in the postgenomic era, the challenge of identifying new signal sequences has become even more urgent and critical in biomedical engineering. In this paper, we propose a novel predictor called Signal-BNF to predict the N-terminal signal peptide as well as its cleavage site based on Bayesian reasoning network. Signal-BNF is formed by fusing the results of different Bayesian classifiers which used different feature datasets as its input through weighted voting system. Experiment results show that Signal-BNF is superior to the popular online predictors such as Signal-3L and PrediSi. Signal-BNF is featured by high prediction accuracy that may serve as a useful tool for further investigating many unclear details regarding the molecular mechanism of the zip code protein-sorting system in cells.

SignalPlant: an open signal processing software platform.

Science.gov (United States)

Plesinger, F; Jurco, J; Halamek, J; Jurak, P

2016-07-01

The growing technical standard of acquisition systems allows the acquisition of large records, often reaching gigabytes or more in size as is the case with whole-day electroencephalograph (EEG) recordings, for example. Although current 64-bit software for signal processing is able to process (e.g. filter, analyze, etc) such data, visual inspection and labeling will probably suffer from rather long latency during the rendering of large portions of recorded signals. For this reason, we have developed SignalPlant-a stand-alone application for signal inspection, labeling and processing. The main motivation was to supply investigators with a tool allowing fast and interactive work with large multichannel records produced by EEG, electrocardiograph and similar devices. The rendering latency was compared with EEGLAB and proves significantly faster when displaying an image from a large number of samples (e.g. 163-times faster for 75  ×  10(6) samples). The presented SignalPlant software is available free and does not depend on any other computation software. Furthermore, it can be extended with plugins by third parties ensuring its adaptability to future research tasks and new data formats.

Automatically annotating web pages using Google Rich Snippets

NARCIS (Netherlands)

Hogenboom, F.P.; Frasincar, F.; Vandic, D.; Meer, van der J.; Boon, F.; Kaymak, U.

2011-01-01

We propose the Automatic Review Recognition and annO- tation of Web pages (ARROW) framework, a framework for Web page review identification and annotation using RDFa Google Rich Snippets. The ARROW framework consists of four steps: hotspot identification, subjectivity analysis, in- formation

Spinal Cord Injury 101

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Plaat

Index Scriptorium Estoniae

2008-01-01

Laseringi kauplustes müügilolevatest heliplaatidest: Sheryl Crow "Detours", Goldfrapp "Seventh Tree", "Eesti Rock Antologia: Shower "Brain Piracy", Shower "Humilator", Nice Try "Nice Try", Jim Arrow & The Anachrones "Jim Arrow & The Anachrones"", Morcheeba "Dive Deep", Hot Chip "Made In The Dark"

Biological Information Processing in Single Microtubules

Science.gov (United States)

2014-03-05

generated by synchronized oscillations of microtubules, centrosomes and chromosomes regulate the dynamics of mitosis and meiosis, Yue Zhao and Qimin...of frequency by a single microtubule. Green arrows depict the peaks that appear in absorption and disappear in transmission. Purple arrows show

Jerusalem artichoke above ground biomass

Energy Technology Data Exchange (ETDEWEB)

Lemieux, C.; Pageau, D.; Dubuc, J-P. [Agriculture and Agri-Food Canada, Ste. Foy, PQ (Canada)

1997-07-01

The possibility of using Jerusalem artichoke in an ethanol production scheme was discussed. A study was conducted to determine the yield stability, competitive ability and weed control requirements of this member of the sunflower family under the climatic conditions in eastern Canada. Two cultivars, the sunroot and fusil, were planted at four experimental sites in which three weed control treatments were tested (two arrowings, one arrowing, and no control). During the establishment, there was little difference between one and two arrowings, but the no weed control treatment was harmful to crop growth. It was concluded that Jerusalem artichoke is very competitive, and if it were included in an ethanol production scheme, weed control would only be necessary in the establishment year. After that, a single arrowing three to four weeks after planting would be sufficient to ensure proper establishment of the plant stand. 4 refs., 1 tab., 2 figs.

Primera validación del algoritmo de ajuste GSF para la reconstrucción de vértices primarios para los decaimientos $H \\to ZZ \\to 4e^-$ y $H \\to ZZ \\to 4mu$ en el experimento de CMS

CERN Document Server

Santacruz Sarmiento, Neida Mirey

2007-01-01

The pixel detector is the most internal detector of the tracking system on the CMS experiment at the LHC. This detector provides the most accurate measurements for a complete reconstruction of traces and vertices of charged particles. The fitting algorithms known as KVF, AVF, TKF and GSF for such a reconstruction have been developed, implemented and studied within the working framework of the CMS. At this moment, KVF, AVF and TKF algorithms have been already validated and adjusted to find the best performance for each one in order to select the optimum fit for primary vertices. In the following research work, I offer the data from the first validation of the GSF algorithm for the H [arrow right] ZZ [arrow right] 4 e - and H [arrow right] ZZ [arrow right] 4μ samples, and analyze the obtained results. This kind of validation is on the frontier of research in this field.

Systematics of B(E2;01+→21+) values for even-even nuclei

International Nuclear Information System (INIS)

Raman, S.; Nestor, C.W. Jr.; Bhatt, K.H.

1988-01-01

We have completed a compilation of experimental results for the electric quadrupole transition probability B(E2)up-arrow between the 0 + ground state and the first 2 + state in even-even nuclei. The adopted B(E2)up-arrow values have been employed to test the various systematic, empirical, and theoretical relationships proposed by several authors (Grodzins, Bohr and Mottelson, Wang et al., Ross and Bhaduri, Patnaik et al., Hamamoto, Casten, Moeller and Nix, and Kumar) on a global, local, or regional basis. These systematics offer methods for making reasonable predictions of unmeasured B(E2) values. For nuclei away from closed shells, the SU(3) limit of the intermediate boson approximation implies that the B(E2)up-arrow values are proportional to (e/sub p/N/sub p/+e/sub n/N/sub n/) 2 , where e/sub p /(e/sub n/) is the proton (neutron) effective charge and N/sub p/ (N/sub n/) refers to the number of valence protons (neutrons). This proportionality is consistent with the observed behavior of B(E2)up-arrow vs N/sub p/N/sub n/. For deformed nuclei and the actinides, the B(E2)up-arrow values calculated in a schematic single-particle ''SU(3)'' simulation or large single-j simulation of major shells successfully reproduce not only the empirical variation of the B(E2)up-arrow values but also the observed saturation of these values when plotted against N/sub p/N/sub n/. .AE

Tunable Signal-Off and Signal-On Electrochemical Cisplatin Sensor.

Science.gov (United States)

Wu, Yao; Lai, Rebecca Y

2017-09-19

We report the first electrochemical cisplatin sensor fabricated with a thiolated and methylene blue (MB)-modified oligo-adenine (A)-guanine (G) DNA probe. Depending on the probe coverage, the sensor can behave as a signal-off or signal-on sensor. For the high-coverage sensor, formation of intrastrand Pt(II)-AG adducts rigidifies the oligo-AG probe, resulting in a concentration-dependent decrease in the MB signal. For the low-coverage sensor, the increase in probe-to-probe spacing enables binding of cisplatin via the intrastrand GNG motif (N = A), generating a bend in the probe which results in an increase in the MB current. Although both high-coverage signal-off and low-coverage signal-on sensors are capable of detecting cisplatin, the signal-on sensing mechanism is better suited for real time analysis of cisplatin. The low-coverage sensor has a lower limit of detection, wider optimal AC frequency range, and faster response time. It has high specificity for cisplatin and potentially other Pt(II) drugs and does not cross-react with satraplatin, a Pt(IV) prodrug. It is also selective enough to be employed directly in 50% saliva and 50% urine. This detection strategy may offer a new approach for sensitive and real time analysis of cisplatin in clinical samples.

Basics of SCI Rehabilitation

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Full Text Available ... spinal cord injury? play_arrow What’s the most common misconception about life after a spinal cord injury? ... about sex and intimacy after a spinal cord injury? play_arrow Why are adaptive sports so helpful after a spinal cord injury? play_ ...

ACHP | Heritage Tourism and the Federal Government: Summit I Proceedings

Science.gov (United States)

Search skip specific nav links Home arrow Publications arrow Intro: Heritage Tourism and the Federal Government: Summit I—Report of Proceedings Heritage Tourism and the Federal Government: Summit I—Report of tourism promotes the preservation of communities' historic resources, educates tourists and local

ACHP | Heritage Tourism and the Federal Government: Summit II Proceedings

Science.gov (United States)

Search skip specific nav links Home arrow Publications arrow Intro: Heritage Tourism and the Federal Government: Summit II—Report of Proceedings Heritage Tourism and the Federal Government: Summit II—Report Heritage tourism promotes the preservation of communities' historic resources, educates tourists and local

ACHP | Federal Programs that Can Support Heritage Tourism

Science.gov (United States)

Search skip specific nav links Home arrow Heritage Tourism arrow Federal Programs that Can Support Heritage Tourism Federal Programs that Can Support Heritage Tourism The following is a sampling of federal programs that can help promote and support local or regional heritage tourism initiatives. Historic

ACHP |Partnering to Promote Heritage Tourism in Local Communities: Guidance

Science.gov (United States)

Publications Search skip specific nav links Home arrow Heritage Tourism arrow Partnering to Promote Heritage Tourism in Local Communities: Guidance for Federal Agencies Partnering to Promote Heritage Tourism in historic places. Such tourism - heritage tourism -can result in a variety of tangible and intangible

ACHP | Heritage Tourism and the Federal Government: Northern New Mexico

Science.gov (United States)

Publications Search skip specific nav links Home arrow Publications arrow Intro: Heritage Tourism and the Federal Government: Northern New Mexico Perspectives Heritage Tourism and the Federal Government: Northern information Heritage tourism offers a triple benefit to communities—it promotes the preservation of their

How the Heart Works

Science.gov (United States)

... direction that blood flows through your heart. The light blue arrow shows that blood enters the right atrium of your heart from ... to your lungs through the pulmonary arteries. The light red arrow shows oxygen-rich blood coming from your lungs through the pulmonary veins ...

Signal sciences workshop proceedings

Energy Technology Data Exchange (ETDEWEB)

Candy, J.V.

1997-05-01

This meeting is aimed primarily at signal processing and controls. The technical program for the 1997 Workshop includes a variety of efforts in the Signal Sciences with applications in the Microtechnology Area a new program at LLNL and a future area of application for both Signal/Image Sciences. Special sessions organized by various individuals in Seismic and Optical Signal Processing as well as Micro-Impulse Radar Processing highlight the program, while the speakers at the Signal Processing Applications session discuss various applications of signal processing/control to real world problems. For the more theoretical, a session on Signal Processing Algorithms was organized as well as for the more pragmatic, featuring a session on Real-Time Signal Processing.

Signal sciences workshop. Proceedings

International Nuclear Information System (INIS)

Candy, J.V.

1997-01-01

This meeting is aimed primarily at signal processing and controls. The technical program for the 1997 Workshop includes a variety of efforts in the Signal Sciences with applications in the Microtechnology Area a new program at LLNL and a future area of application for both Signal/Image Sciences. Special sessions organized by various individuals in Seismic and Optical Signal Processing as well as Micro-Impulse Radar Processing highlight the program, while the speakers at the Signal Processing Applications session discuss various applications of signal processing/control to real world problems. For the more theoretical, a session on Signal Processing Algorithms was organized as well as for the more pragmatic, featuring a session on Real-Time Signal Processing

Orexin/Hypocretin Signaling.

Science.gov (United States)

Kukkonen, Jyrki P

Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX 1 and OX 2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other types of cells - and in recombinant cells expressing the receptors in a heterologous manner. Findings in the different systems are partially convergent but also indicate cellular background-specific signaling. The general picture suggests an inherently high degree of diversity in orexin receptor signaling.In the current chapter, I present orexin signaling on the cellular and molecular levels. Discussion of the connection to (potential) physiological orexin responses is only brief since these are in focus of other chapters in this book. The same goes for the post-synaptic signaling mechanisms, which are dealt with in Burdakov: Postsynaptic actions of orexin. The current chapter is organized according to the tissue type, starting from the central nervous system. Finally, receptor signaling pathways are discussed across tissues, cell types, and even species.

Spectral Correlation of Multicarrier Modulated Signals and Its Application for Signal Detection

Directory of Open Access Journals (Sweden)

Zhang Haijian

2010-01-01

Full Text Available Spectral correlation theory for cyclostationary time-series signals has been studied for decades. Explicit formulas of spectral correlation function for various types of analog-modulated and digital-modulated signals are already derived. In this paper, we investigate and exploit the cyclostationarity characteristics for two kinds of multicarrier modulated (MCM signals: conventional OFDM and filter bank based multicarrier (FBMC signals. The spectral correlation characterization of MCM signal can be described by a special linear periodic time-variant (LPTV system. Using this LPTV description, we have derived the explicit theoretical formulas of nonconjugate and conjugate cyclic autocorrelation function (CAF and spectral correlation function (SCF for OFDM and FBMC signals. According to theoretical spectral analysis, Cyclostationary Signatures (CS are artificially embedded into MCM signal and a low-complexity signature detector is, therefore, presented for detecting MCM signal. Theoretical analysis and simulation results demonstrate the efficiency and robustness of this CS detector compared to traditionary energy detector.

ATP signals

DEFF Research Database (Denmark)

Novak, Ivana

2016-01-01

The Department of Biology at the University of Copenhagen explains the function of ATP signalling in the pancreas......The Department of Biology at the University of Copenhagen explains the function of ATP signalling in the pancreas...

Basic digital signal processing

CERN Document Server

Lockhart, Gordon B

1985-01-01

Basic Digital Signal Processing describes the principles of digital signal processing and experiments with BASIC programs involving the fast Fourier theorem (FFT). The book reviews the fundamentals of the BASIC program, continuous and discrete time signals including analog signals, Fourier analysis, discrete Fourier transform, signal energy, power. The text also explains digital signal processing involving digital filters, linear time-variant systems, discrete time unit impulse, discrete-time convolution, and the alternative structure for second order infinite impulse response (IIR) sections.

ACHP | News | Laura Bush Announces Preserve America Grants Budget

Science.gov (United States)

Search skip specific nav links Home arrow News arrow Laura Bush Announces Preserve America Grants Budget Laura Bush Announces Preserve America Grants Budget First Preserve America Communities Also Announced ) Jan. 15, 2004, Washington, DC—Mrs. Laura Bush announced today that the President's budget for FY 2005

Paul D. Boyer, Adenosine Triphosphate (ATP), and the Binding Change

Science.gov (United States)

Mechanism RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics Stories Snapshots R&D Nuggets Database dropdown arrow Search Tag Cloud Browse Reports Database Help

Images in medicine

African Journals Online (AJOL)

abp

2015-07-31

Jul 31, 2015 ... A retrograde urethrocystography, performed after a. 10-days course of antibiotics, confirmed the presence of an approximately 35 mm non-obstructive calculus occupying almost the whole prostatic bed (Red arrows) with a stricture of the membranous urethra (Yellow arrow), the bladder however showed.

Indirect carotid- cavernous fistula — embolisation using the superior ...

African Journals Online (AJOL)

Kurt

MD, FRCS (C). Division of Neurosurgery. Royal University Hospital. University of Saskatchewan. Saskatoon. Canada. Fig .1a. Left common carotid angiogram, AP view, showing the carotid-cavernous fistula. Note opaci- fication of the left cavernous sinus (arrow) and fill- ing of the right cavernous sinus (double arrows).

75 FR 61757 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2010-10-06

...), Jinho Um, CFO. Application Type: New NVO & OFF License. Junction Int'l Logistics, Inc. (NVO), 17870 Castleton Street, Suite 107, City of Industry, CA 91748. Officers: Charles Kuo, Secretary (Qualifying.... Application Type: New NVO & OFF License. Red Arrow Consulting, Inc. dba Red Arrow Logistics (OFF), 14925 SE...

Spinal Cord Injury 101

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Full Text Available ... Abuse and Spinal Cord Injury Allen Heinemann, PhD How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal ... What is a spinal cord injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a ...

Rabi oscillations and rapid-passage effects in the molecular-beam CO2-laser Stark spectroscopy of CH3F

International Nuclear Information System (INIS)

Adam, A.G.; Gough, T.E.; Isenor, N.R.; Scoles, G.

1985-01-01

sub-Doppler molecular-beam laser Stark spectroscopy has been employed to produce high-contrast Rabi oscillations in the ν 3 band of CH 3 F. By varying the intensity of the cw CO 2 laser, up to five complete oscillations were observed before the phenomenon was washed out by rapid-passage effects and damping mechanisms. Besides being useful in clarifying key features of coherent ir molecular-beam spectroscopy, the observation of Rabi oscillations provides one of the most accurate means of directly measuring transition dipole moments. Analysis of the present data on three rovibrational transitions, Q(1,1) -1reverse arrow0, P(1,0) 0reverse arrow0, and R(1,1) 0reverse arrow1, has yielded a rotationless transition dipole moment of 0.21 +- 0.01 D for the ν 3 = 1reverse arrow0 vibration. This result is in agreement with values estimated from both band-intensity and absorption-coefficient data in the literature

ECG signal processing

NARCIS (Netherlands)

2009-01-01

A system extracts an ECG signal from a composite signal (308) representing an electric measurement of a living subject. Identification means (304) identify a plurality of temporal segments (309) of the composite signal corresponding to a plurality of predetermined segments (202,204,206) of an ECG

Nichtkontinuierliche (zeitdiskrete) Signale

Science.gov (United States)

Plaßmann, Wilfried

Zeitdiskrete Signale werden häufig aus zeitkontinuierlichen Signalen durch Abtastung erzeugt. Dass beide Signale gleichwertig sind, zeigt das Abtasttheorem (Kap. 116) von Shannon, sofern die Bedingung nach (116.2), f_{ab}≈(2{,}2 {\\ldots} 4)\\cdot fg) eingehalten wird. Digitale Signale haben Vorteile: Einfache Speicherung, Weiterverarbeitung in Rechnern, wenig störanfällige Übertragung. Für die Bearbeitung dieser Signale dienen die im Kapitel dargestellten Hilfsmittel: Diskrete Fouriertransformation; Schnelle Fouriertransformation; z-Transformation: Darstellung, Sätze zur z-Transformation, Korrespondenzen zu Zeitfunktionen, Beispiele.

Digital signal processing

CERN Document Server

O'Shea, Peter; Hussain, Zahir M

2011-01-01

In three parts, this book contributes to the advancement of engineering education and that serves as a general reference on digital signal processing. Part I presents the basics of analog and digital signals and systems in the time and frequency domain. It covers the core topics: convolution, transforms, filters, and random signal analysis. It also treats important applications including signal detection in noise, radar range estimation for airborne targets, binary communication systems, channel estimation, banking and financial applications, and audio effects production. Part II considers sel

Silicon Photonics for Signal Processing of Tbit/s Serial Data Signals

DEFF Research Database (Denmark)

Oxenløwe, Leif Katsuo; Ji, Hua; Galili, Michael

2012-01-01

In this paper, we describe our recent work on signal processing of terabit per second optical serial data signals using pure silicon waveguides. We employ nonlinear optical signal processing in nanoengineered silicon waveguides to perform demultiplexing and optical waveform sampling of 1.28-Tbit/...

Muon Signals at a Low Signal-to-Noise Ratio Environment

CERN Document Server

Zakareishvili, Tamar; The ATLAS collaboration

2017-01-01

Calorimeters provide high-resolution energy measurements for particle detection. Muon signals are important for evaluating electronics performance, since they produce a signal that is close to electronic noise values. This work provides a noise RMS analysis for the Demonstrator drawer of the 2016 Tile Calorimeter (TileCal) Test Beam in order to help reconstruct events in a low signal-to-noise environment. Muon signals were then found for a beam penetrating through all three layers of the drawer. The Demonstrator drawer is an electronic candidate for TileCal, part of the ATLAS experiment for the Large Hadron Collider that operates at the European Organization for Nuclear Research (CERN).

ACHP | News | St. Elizabeths Programmatic Agreement Signed

Science.gov (United States)

Search skip specific nav links Home arrow News arrow St. Elizabeths Programmatic Agreement Signed St redevelopment of the St. Elizabeths West Campus, which is part of the St. Elizabeths National Historic Landmark this project, due to the historic significance of the NHL. GSA's client for the St. Elizabeths

Signals, systems, transforms, and digital signal processing with Matlab

CERN Document Server

Corinthios, Michael

2009-01-01

Continuous-Time and Discrete-Time Signals and SystemsIntroductionContinuous-Time SignalsPeriodic FunctionsUnit Step FunctionGraphical Representation of FunctionsEven and Odd Parts of a FunctionDirac-Delta ImpulseBasic Properties of the Dirac-Delta ImpulseOther Important Properties of the ImpulseContinuous-Time SystemsCausality, StabilityExamples of Electrical Continuous-Time SystemsMechanical SystemsTransfer Function and Frequency ResponseConvolution and CorrelationA Right-Sided and a Left-Sided FunctionConvolution with an Impulse and Its DerivativesAdditional Convolution PropertiesCorrelation FunctionProperties of the Correlation FunctionGraphical InterpretationCorrelation of Periodic FunctionsAverage, Energy and Power of Continuous-Time SignalsDiscrete-Time SignalsPeriodicityDifference EquationsEven/Odd DecompositionAverage Value, Energy and Power SequencesCausality, StabilityProblemsAnswers to Selected ProblemsFourier Series ExpansionTrigonometric Fourier SeriesExponential Fourier SeriesExponential versus ...

Quorum Quenching Revisited—From Signal Decays to Signalling Confusion

Directory of Open Access Journals (Sweden)

Kok-Gan Chan

2012-04-01

Full Text Available In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing, others are interrupting the communication (quorum quenching, thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes have been found and initially thought to inactivate the signalling molecules. Though this is widely accepted, the actual roles of these quorum quenching enzymes are now being uncovered. Recent evidence extends the role of quorum quenching to detoxification or metabolism of signalling molecules as food and energy source; this includes “signalling confusion”, a term coined in this paper to refer to the phenomenon of non-destructive modification of signalling molecules. While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching.

Measurand transient signal suppressor

Science.gov (United States)

Bozeman, Richard J., Jr. (Inventor)

1994-01-01

A transient signal suppressor for use in a controls system which is adapted to respond to a change in a physical parameter whenever it crosses a predetermined threshold value in a selected direction of increasing or decreasing values with respect to the threshold value and is sustained for a selected discrete time interval is presented. The suppressor includes a sensor transducer for sensing the physical parameter and generating an electrical input signal whenever the sensed physical parameter crosses the threshold level in the selected direction. A manually operated switch is provided for adapting the suppressor to produce an output drive signal whenever the physical parameter crosses the threshold value in the selected direction of increasing or decreasing values. A time delay circuit is selectively adjustable for suppressing the transducer input signal for a preselected one of a plurality of available discrete suppression time and producing an output signal only if the input signal is sustained for a time greater than the selected suppression time. An electronic gate is coupled to receive the transducer input signal and the timer output signal and produce an output drive signal for energizing a control relay whenever the transducer input is a non-transient signal which is sustained beyond the selected time interval.

Adaptive signal processor

Energy Technology Data Exchange (ETDEWEB)

Walz, H.V.

1980-07-01

An experimental, general purpose adaptive signal processor system has been developed, utilizing a quantized (clipped) version of the Widrow-Hoff least-mean-square adaptive algorithm developed by Moschner. The system accommodates 64 adaptive weight channels with 8-bit resolution for each weight. Internal weight update arithmetic is performed with 16-bit resolution, and the system error signal is measured with 12-bit resolution. An adapt cycle of adjusting all 64 weight channels is accomplished in 8 ..mu..sec. Hardware of the signal processor utilizes primarily Schottky-TTL type integrated circuits. A prototype system with 24 weight channels has been constructed and tested. This report presents details of the system design and describes basic experiments performed with the prototype signal processor. Finally some system configurations and applications for this adaptive signal processor are discussed.

Adaptive signal processor

International Nuclear Information System (INIS)

Walz, H.V.

1980-07-01

An experimental, general purpose adaptive signal processor system has been developed, utilizing a quantized (clipped) version of the Widrow-Hoff least-mean-square adaptive algorithm developed by Moschner. The system accommodates 64 adaptive weight channels with 8-bit resolution for each weight. Internal weight update arithmetic is performed with 16-bit resolution, and the system error signal is measured with 12-bit resolution. An adapt cycle of adjusting all 64 weight channels is accomplished in 8 μsec. Hardware of the signal processor utilizes primarily Schottky-TTL type integrated circuits. A prototype system with 24 weight channels has been constructed and tested. This report presents details of the system design and describes basic experiments performed with the prototype signal processor. Finally some system configurations and applications for this adaptive signal processor are discussed

Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish

Science.gov (United States)

Swartz, Mary E.; McCarthy, Neil; Norrie, Jacqueline L.; Eberhart, Johann K.

2016-01-01

The endodermal pouches are a series of reiterated structures that segment the pharyngeal arches and help pattern the vertebrate face. Multiple pathways regulate the complex process of endodermal development, including the Bone morphogenetic protein (Bmp) pathway. However, the role of Bmp signaling in pouch morphogenesis is poorly understood. Using genetic and chemical inhibitor approaches, we show that pouch morphogenesis requires Bmp signaling from 10-18 h post-fertilization, immediately following gastrulation. Blocking Bmp signaling during this window results in morphological defects to the pouches and craniofacial skeleton. Using genetic chimeras we show that Bmp signals directly to the endoderm for proper morphogenesis. Time-lapse imaging and analysis of reporter transgenics show that Bmp signaling is necessary for pouch outpocketing via the Fibroblast growth factor (Fgf) pathway. Double loss-of-function analyses demonstrate that Bmp and Fgf signaling interact synergistically in craniofacial development. Collectively, our analyses shed light on the tissue and signaling interactions that regulate development of the vertebrate face. PMID:27122171

To signal or not to signal: that should not be the question.

Science.gov (United States)

Faw, Harold W

2013-10-01

The purpose of the present research was to examine rates of turn signal use, a positive and potentially valuable means by which drivers can communicate. A second purpose was to explore factors that might impact these rates, including the modeling influence of other drivers. A series of observations involving more than 5600 vehicles making turns were recorded at a variety of intersections in British Columbia, Canada. Though the occurrence of signal use varied widely, ranging from a low of 54% to a high of 95%, the overall rate was 76%. Drivers used turn signals significantly less often when making right as compared with left turns, when traffic volume was higher, and when a designated turning lane was provided. In addition, compared with drivers following another vehicle not using signals, those following a vehicle with turn signals on were significantly more likely to activate their turn signals, suggesting a possible modeling effect. Both internal and external influences on turn signal use by drivers were considered. External factors explored in this research included direction of turn, traffic volume, intersection configuration, and the example of other drivers. It was concluded that the practice of signaling turns merits more research attention, since consistent use of signals is a potential contributor to enhanced safety for all road users. Copyright © 2013 Elsevier Ltd. All rights reserved.

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.

Science.gov (United States)

Zhong, Jun; Sharma, Jyoti; Raju, Rajesh; Palapetta, Shyam Mohan; Prasad, T S Keshava; Huang, Tai-Chung; Yoda, Akinori; Tyner, Jeffrey W; van Bodegom, Diederik; Weinstock, David M; Ziegler, Steven F; Pandey, Akhilesh

2014-01-01

Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24.

Interrogative suggestibility and perceptual motor performance.

Science.gov (United States)

Gudjonsson, G H

1984-04-01

This study investigates the relationship between interrogative suggestibility, as measured by the Gudjonsson Suggestibility Scale, and Arrow-Dot scores. The tendency of subjects (25 men and 25 women, mean age 30.2 yr.) to alter their answers once interpersonal pressure had been applied correlated significantly with poor Arrow-Dot Ego functioning.

Basics of SCI Rehabilitation

Medline Plus

Full Text Available ... Abuse and Spinal Cord Injury Allen Heinemann, PhD How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal ... difficult obstacle to overcome in rehabilitation? play_arrow How soon should people return to school or work after a spinal cord injury? play_arrow What’s ...

On the relevance of source effects in geomagnetic pulsations for induction soundings

Science.gov (United States)

Neska, Anne; Tadeusz Reda, Jan; Leszek Neska, Mariusz; Petrovich Sumaruk, Yuri

2018-03-01

This study is an attempt to close a gap between recent research on geomagnetic pulsations and their usage as source signals in electromagnetic induction soundings (i.e., magnetotellurics, geomagnetic depth sounding, and magnetovariational sounding). The plane-wave assumption as a precondition for the proper performance of these methods is partly violated by the local nature of field line resonances which cause a considerable portion of pulsations at mid latitudes. It is demonstrated that and explained why in spite of this, the application of remote reference stations in quasi-global distances for the suppression of local correlated-noise effects in induction arrows is possible in the geomagnetic pulsation range. The important role of upstream waves and of the magnetic equatorial region for such applications is emphasized. Furthermore, the principal difference between application of reference stations for local transfer functions (which result in sounding curves and induction arrows) and for inter-station transfer functions is considered. The preconditions for the latter are much stricter than for the former. Hence a failure to estimate an inter-station transfer function to be interpreted in terms of electromagnetic induction, e.g., because of field line resonances, does not necessarily prohibit use of the station pair for a remote reference estimation of the impedance tensor.

On the relevance of source effects in geomagnetic pulsations for induction soundings

Directory of Open Access Journals (Sweden)

A. Neska

2018-03-01

Full Text Available This study is an attempt to close a gap between recent research on geomagnetic pulsations and their usage as source signals in electromagnetic induction soundings (i.e., magnetotellurics, geomagnetic depth sounding, and magnetovariational sounding. The plane-wave assumption as a precondition for the proper performance of these methods is partly violated by the local nature of field line resonances which cause a considerable portion of pulsations at mid latitudes. It is demonstrated that and explained why in spite of this, the application of remote reference stations in quasi-global distances for the suppression of local correlated-noise effects in induction arrows is possible in the geomagnetic pulsation range. The important role of upstream waves and of the magnetic equatorial region for such applications is emphasized. Furthermore, the principal difference between application of reference stations for local transfer functions (which result in sounding curves and induction arrows and for inter-station transfer functions is considered. The preconditions for the latter are much stricter than for the former. Hence a failure to estimate an inter-station transfer function to be interpreted in terms of electromagnetic induction, e.g., because of field line resonances, does not necessarily prohibit use of the station pair for a remote reference estimation of the impedance tensor.

Method of signal analysis

International Nuclear Information System (INIS)

Berthomier, Charles

1975-01-01

A method capable of handling the amplitude and the frequency time laws of a certain kind of geophysical signals is described here. This method is based upon the analytical signal idea of Gabor and Ville, which is constructed either in the time domain by adding an imaginary part to the real signal (in-quadrature signal), or in the frequency domain by suppressing negative frequency components. The instantaneous frequency of the initial signal is then defined as the time derivative of the phase of the analytical signal, and his amplitude, or envelope, as the modulus of this complex signal. The method is applied to three types of magnetospheric signals: chorus, whistlers and pearls. The results obtained by analog and numerical calculations are compared to results obtained by classical systems using filters, i.e. based upon a different definition of the concept of frequency. The precision with which the frequency-time laws are determined leads then to the examination of the principle of the method and to a definition of instantaneous power density spectrum attached to the signal, and to the first consequences of this definition. In this way, a two-dimensional representation of the signal is introduced which is less deformed by the analysis system properties than the usual representation, and which moreover has the advantage of being obtainable practically in real time [fr

The Hedgehog Signal Induced Modulation of Bone Morphogenetic Protein Signaling: An Essential Signaling Relay for Urinary Tract Morphogenesis

Science.gov (United States)

Nakagata, Naomi; Miyagawa, Shinichi; Suzuki, Kentaro; Kitazawa, Sohei; Yamada, Gen

2012-01-01

Background Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects in such progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Methodology/Principal Findings To elucidate the pathogenic mechanisms of upper urinary tract malformations, we analyzed a series of Sonic hedgehog (Shh) deficient mice. Shh−/− displayed hydroureter and hydronephrosis phenotypes and reduced expression of several developmental markers. In addition, we suggested that Shh modulation at an early embryonic stage is responsible for such phenotypes by analyzing the Shh conditional mutants. Tissue contribution assays of Hh-responsive cells revealed that peri-cloacal mesenchymal cells, which received Hh signal secreted from cloacal epithelium, could contribute to the ureteral mesenchyme. Gain- and loss-of-functional mutants for Hh signaling revealed a correlation between Hh signaling and Bone morphogenetic protein (Bmp) signaling. Finally, a conditional ablation of Bmp receptor type IA (BmprIA) gene was examined in Hh-responsive cell lineages. This system thus made it possible to analyze the primary functions of the growth factor signaling relay. The defective Hh-to-Bmp signaling relay resulted in severe urinary tract phenotypes with a decrease in the number of Hh-responsive cells. Conclusions/Significance This study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh

The newest digital signal processing

International Nuclear Information System (INIS)

Lee, Chae Uk

2002-08-01

This book deal with the newest digital signal processing, which contains introduction on conception of digital signal processing, constitution and purpose, signal and system such as signal, continuos signal, discrete signal and discrete system, I/O expression on impress response, convolution, mutual connection of system and frequency character,z transform of definition, range, application of z transform and relationship with laplace transform, Discrete fourier, Fast fourier transform on IDFT algorithm and FFT application, foundation of digital filter of notion, expression, types, frequency characteristic of digital filter and design order of filter, Design order of filter, Design of FIR digital filter, Design of IIR digital filter, Adaptive signal processing, Audio signal processing, video signal processing and application of digital signal processing.

Mathematical properties of a semi-classical signal analysis method: Noisy signal case

KAUST Repository

Liu, Dayan

2012-08-01

Recently, a new signal analysis method based on a semi-classical approach has been proposed [1]. The main idea in this method is to interpret a signal as a potential of a Schrodinger operator and then to use the discrete spectrum of this operator to analyze the signal. In this paper, we are interested in a mathematical analysis of this method in discrete case considering noisy signals. © 2012 IEEE.

Mathematical properties of a semi-classical signal analysis method: Noisy signal case

KAUST Repository

Liu, Dayan; Laleg-Kirati, Taous-Meriem

2012-01-01

Recently, a new signal analysis method based on a semi-classical approach has been proposed [1]. The main idea in this method is to interpret a signal as a potential of a Schrodinger operator and then to use the discrete spectrum of this operator to analyze the signal. In this paper, we are interested in a mathematical analysis of this method in discrete case considering noisy signals. © 2012 IEEE.

Assessment of Vert-3D repeatability and reproducibility for evaluating the scoliosis of children with different nutritional profiles

Directory of Open Access Journals (Sweden)

Juliana Adami Sedrez

Full Text Available Abstract Introduction: The Vert-3D is a radiation-free system which offers a three-dimensional view of the back’s surface, providing a quantitative assessment of spinal curvatures. Objective: To verify the repeatability, inter-rater reproducibility, and correlation between Cobb angles and the results of the Vert-3D system version 1 in the evaluation of the front curvatures of the spine in children with different nutritional profiles. Methods: The sample was composed of 115 children who underwent posterior-anterior panoramic digital radiography of the spine and five evaluations with the Vert-3D system by three trained raters. Results: Version 1 of the Vert-3D system showed: (1 significant and moderate correlations of repeatability for arrows on the left (ICC between .54 to .83 and significant and moderate correlations for arrows on the right (ICC between .55 to .60 for only normal BMI; (2 significant correlations of inter-rater reproducibility for left arrows (ICC between .47 to .65, weak to moderate correlations for right arrows (ICC between .29 to .60, and no significance for obese samples; and (3 significant correlations ranging between .31 and .60 on the left side and non-significant correlations to the right side between Cobb angles and scoliosis arrows. Conclusion: High correlation levels solely on the left side decrease the possibility of system-use for the assessment of scoliosis.

Improved prediction of signal peptides: SignalP 3.0

DEFF Research Database (Denmark)

Bendtsen, Jannick Dyrløv; Nielsen, Henrik; von Heijne, G.

2004-01-01

We describe improvements of the currently most popular method for prediction of classically secreted proteins, SignalP. SignalP consists of two different predictors based on neural network and hidden Markov model algorithms, where both components have been updated. Motivated by the idea that the ...

Attention and Gaze Control in Picture Naming, Word Reading, and Word Categorizing

Science.gov (United States)

Roelofs, Ardi

2007-01-01

The trigger for shifting gaze between stimuli requiring vocal and manual responses was examined. Participants were presented with picture-word stimuli and left- or right-pointing arrows. They vocally named the picture (Experiment 1), read the word (Experiment 2), or categorized the word (Experiment 3) and shifted their gaze to the arrow to…

Basics of SCI Rehabilitation

Medline Plus

Full Text Available ... spinal cord injury? play_arrow Why are adaptive sports so helpful after a spinal cord injury? play_arrow What’s your best advice for patients and families after a spinal cord injury? What is a Spinal Cord Injury? SCI Medical Experts People Living With SCI Personal Experiences By Topic ...

Uncooled Split-off Quantum Infrared Sensors for 3-5 Micron Imaging Applications

Science.gov (United States)

2012-12-20

15 (b) (arrow), gradually raising the potential in Contact 1 to be higher than the emitter and Contact 2, until a built-in potential difference Vph ...presence of a graded barrier, a net flow of holes occurs, as indicated by the arrow, until a new equilibrium with a built-in potential Vph is

Teachers' Occupation-Specific Work-Family Conflict

Science.gov (United States)

Cinamon, Rachel Gali; Rich, Yisrael; Westman, Mina

2007-01-01

To expand work-family conflict (WFC) research to specific occupations, this study investigated how work and family generic and occupation-specific stressors and support variables related to family interfering with work (F [right arrow] W) and work interfering with family (W [right arrow] F) among 230 Israeli high school teachers. Further expanding…

Arrows as Anchors: An Analysis of the Material Features of Electric Field Vector Arrows

Science.gov (United States)

Gire, Elizabeth; Price, Edward

2014-01-01

Representations in physics possess both physical and conceptual aspects that are fundamentally intertwined and can interact to support or hinder sense making and computation. We use distributed cognition and the theory of conceptual blending with material anchors to interpret the roles of conceptual and material features of representations in…

Tyrosine kinase signalling in breast cancer: Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates

International Nuclear Information System (INIS)

Kairouz, Rania; Daly, Roger J

2000-01-01

The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transduction. Given the strong evidence that links signalling by certain families of RTKs to the progression of breast cancer, it is not surprising that the expression profile of key downstream signalling intermediates in this disease has also come under scrutiny, particularly because some exhibit transforming potential or amplify mitogenic signalling pathways when they are overexpressed. Reflecting the diverse cellular processes regulated by RTKs, it is now clear that altered expression of such signalling proteins in breast cancer may influence not only cellular proliferation (eg Grb2) but also the invasive properties of the cancer cells (eg EMS1/cortactin)

Wnt signaling in cancer

Science.gov (United States)

Zhan, T; Rindtorff, N; Boutros, M

2017-01-01

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches. PMID:27617575

Signal Conditioning An Introduction to Continuous Wave Communication and Signal Processing

CERN Document Server

Das, Apurba

2012-01-01

"Signal Conditioning” is a comprehensive introduction to electronic signal processing. The book presents the mathematical basics including the implications of various transformed domain representations in signal synthesis and analysis in an understandable and lucid fashion and illustrates the theory through many applications and examples from communication systems. The ease to learn is supported by well-chosen exercises which give readers the flavor of the subject. Supplementary electronic materials available on http://extras.springer.com including MATLAB codes illuminating applications in the domain of one dimensional electrical signal processing, image processing and speech processing. The book is an introduction for students with a basic understanding in engineering or natural sciences.

Identification and Comprehension of Symbolic Exit Signs for Small Transport-Category Airplanes

Science.gov (United States)

2014-02-01

for the ISO running man and the narrow arrows, a comprehension score of 38% for the modi - fied running man and wide arrows, and a comprehension score... Diabetic Retinopalhy Study (ETDRS). Sloan font oourtesy of Denis Pelli. This cllart and more available at 1-SEE.org A2 Page 2: ETDRS Chart 1 A3

Graphic Representation of Force in Secondary Education: Analysis and Alternative Educational Proposals.

Science.gov (United States)

Jimenez-Valladares, Juan de Dios; Perales-Palacios, F. Javier

2001-01-01

When students are forming their ideas of what will eventually become the concept of force, the images of arrows in our standard diagrams carry with them unconscious attributes of direction of movement and so on. Describes how the use of a 'symbolic representation of interactions' with double-headed arrows avoids these unwanted messages being…

Attention, Exposure Duration, and Gaze Shifting in Naming Performance

Science.gov (United States)

Roelofs, Ardi

2011-01-01

Two experiments are reported in which the role of attribute exposure duration in naming performance was examined by tracking eye movements. Participants were presented with color-word Stroop stimuli and left- or right-pointing arrows on different sides of a computer screen. They named the color attribute and shifted their gaze to the arrow to…

Podcast Effectiveness as Scaffolding Support for Students Enrolled in First-Semester General Chemistry Laboratories

Science.gov (United States)

Powell, Mary Cynthia Barton

2010-01-01

Podcasts covering essential first-semester general chemistry laboratory techniques and central concepts that aid in experimental design or data processing were prepared and made available for students to access on an as-needed basis on iPhones [arrow right] or iPod touches [arrow right]. Research focused in three areas: the extent of podcast…

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Freek Wiedijk. Articles written in Sadhana. Volume 34 Issue 1 February 2009 pp 193-220. Formalizing Arrow's theorem · Freek Wiedijk · More Details Abstract Fulltext PDF. A small project in which I encoded a proof of Arrow's theorem—probably the most famous results in the economics field of ...

Inclusive decays of {ital B} mesons to charmonium

Energy Technology Data Exchange (ETDEWEB)

Balest, R.; Cho, K.; Ford, W.T.; Johnson, D.R.; Lingel, K.; Lohner, M.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Gaidarev, P.; Garcia-Sciveres, M.; Geiser, B.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Salman, S.; Sapper, M.; Wuerthwein, F.; Avery, P.; Freyberger, A.; Rodriguez, J.; Yang, S.; Yelton, J.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Gollin, G.; Ong, B.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kelly, M.; Kotov, S.; Kravchenko, I.; Kwak, N.; Lam, H.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O`Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Daubenmier, C.M.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Butler, F.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; McIlwain, R.L.; Miao, T.; Miller, D.H.; Modesitt, M.; Payne, D.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Battle, M.; Ernst, J.; Gibbons, L.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Wang, C.H.; Dominick, J.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Moneti, G.C.; (CLEO Collabor...

1995-09-01

We have used the CLEO-II detector at the Cornell Electron Storage Ringe (CESR) to study the inclusive production of charmonium mesons in a sample of 2.15 million {ital B{bar B}} events. We find inclusive branching fractions of (1.12{plus_minus}0.04{plus_minus}0.06)% for {ital B}{r_arrow}{ital J}/{psi}{ital X}, (0.34{plus_minus}0.04{plus_minus}0.03)% for {ital B}{r_arrow}{psi}{prime}{ital X}, and (0.40{plus_minus}0.06{plus_minus}0.04)% for {ital B}{r_arrow}{chi}{sub {ital c}1}{ital X}. We also find some evidence for the inclusive production of {chi}{sub {ital c}2}, and set an upper limit for the branching fraction of the inclusive decay {ital B}{r_arrow}{eta}{sub {ital c}}{ital X} of 0.9% at 90% confidence level. Momentum spectra for inclusive {ital J}/{psi}, {psi}{prime}, and {chi}{sub {ital c}1} production are presented. These measurements are compared to theoretical calculations.

Correlation of Respiratory Signals and Electrocardiogram Signals via Empirical Mode Decomposition

KAUST Repository

El Fiky, Ahmed Osama

2011-05-24

Recently Electrocardiogram (ECG) signals are being broadly used as an essential diagnosing tool in different clinical applications as they carry a reliable representation not only for cardiac activities, but also for other associated biological processes, like respiration. However, the process of recording and collecting them has usually suffered from the presence of some undesired noises, which in turn affects the reliability of such representations.Therefore, de-noising ECG signals became a hot research field for signal processing experts to ensure better and clear representation of the different cardiac activities. Given the nonlinear and non-stationary properties of ECGs, it is not a simple task to cancel the undesired noise terms without affecting the biological physics of them. In this study, we are interested in correlating the ECG signals with respiratory parameters, specifically the lung volume and lung pressure. We have focused on the concept of de-noising ECG signals by means of signal decomposition using an algorithm called the Empirical Mode Decomposition (EMD) where the original ECG signals are being decomposed into a set of intrinsic mode functions (IMF). Then, we have provided criteria based on which some of these IMFs have been adapted to reconstruct de-noised ECG version. Finally, we have utilized de-noised ECGs as well as IMFs for to study the correlation with lung volume and lung pressure. These correlation studies have showed some clear resemblance especially between the oscillations of ECGs and lung pressures.

Detection test of wireless network signal strength and GPS positioning signal in underground pipeline

Science.gov (United States)

Li, Li; Zhang, Yunwei; Chen, Ling

2018-03-01

In order to solve the problem of selecting positioning technology for inspection robot in underground pipeline environment, the wireless network signal strength and GPS positioning signal testing are carried out in the actual underground pipeline environment. Firstly, the strength variation of the 3G wireless network signal and Wi-Fi wireless signal provided by China Telecom and China Unicom ground base stations are tested, and the attenuation law of these wireless signals along the pipeline is analyzed quantitatively and described. Then, the receiving data of the GPS satellite signal in the pipeline are tested, and the attenuation of GPS satellite signal under underground pipeline is analyzed. The testing results may be reference for other related research which need to consider positioning in pipeline.

DMPD: Signal integration between IFNgamma and TLR signalling pathways in macrophages. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16920490 Signal integration between IFNgamma and TLR signalling pathways in macroph...tml) (.csml) Show Signal integration between IFNgamma and TLR signalling pathways in macrophages. PubmedID 16920490 Title Signal inte...gration between IFNgamma and TLR signalling pathways in

Sinusoidal Representation of Acoustic Signals

Science.gov (United States)

Honda, Masaaki

Sinusoidal representation of acoustic signals has been an important tool in speech and music processing like signal analysis, synthesis and time scale or pitch modifications. It can be applicable to arbitrary signals, which is an important advantage over other signal representations like physical modeling of acoustic signals. In sinusoidal representation, acoustic signals are composed as sums of sinusoid (sine wave) with different amplitudes, frequencies and phases, which is based on the timedependent short-time Fourier transform (STFT). This article describes the principles of acoustic signal analysis/synthesis based on a sinusoid representation with focus on sine waves with rapidly varying frequency.

Non-Smad signaling pathways.

Science.gov (United States)

Mu, Yabing; Gudey, Shyam Kumar; Landström, Maréne

2012-01-01

Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex phosphorylates Smad2 and Smad3, converting them into transcriptional regulators that complex with Smad4. TGFβ also uses non-Smad signaling pathways such as the p38 and Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways to convey its signals. Ubiquitin ligase tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6) and TGFβ-associated kinase 1 (TAK1) have recently been shown to be crucial for the activation of the p38 and JNK MAPK pathways. Other TGFβ-induced non-Smad signaling pathways include the phosphoinositide 3-kinase-Akt-mTOR pathway, the small GTPases Rho, Rac, and Cdc42, and the Ras-Erk-MAPK pathway. Signals induced by TGFβ are tightly regulated and specified by post-translational modifications of the signaling components, since they dictate the subcellular localization, activity, and duration of the signal. In this review, we discuss recent findings in the field of TGFβ-induced responses by non-Smad signaling pathways.

Alternatives to Pyrotechnic Distress Signals; Additional Signal Evaluation

Science.gov (United States)

2017-06-01

device performance standard that addresses Coast Guard project sponsor and stakeholders needs. 17. Key Words Visual Distress Signal Device (VDSD...devices. The report discussed the concept of “effective intensity,” as used by the International Association of Marine Aids to Navigation and Lighthouse...efficacy of Cyan as a signal color. In order to move forward, the RDC project team met with CG-ENG-4 and other Coast Guard stakeholders (Offices of

Signal existence verification (SEV) for GPS low received power signal detection using the time-frequency approach.

Science.gov (United States)

Jan, Shau-Shiun; Sun, Chih-Cheng

2010-01-01

The detection of low received power of global positioning system (GPS) signals in the signal acquisition process is an important issue for GPS applications. Improving the miss-detection problem of low received power signal is crucial, especially for urban or indoor environments. This paper proposes a signal existence verification (SEV) process to detect and subsequently verify low received power GPS signals. The SEV process is based on the time-frequency representation of GPS signal, and it can capture the characteristic of GPS signal in the time-frequency plane to enhance the GPS signal acquisition performance. Several simulations and experiments are conducted to show the effectiveness of the proposed method for low received power signal detection. The contribution of this work is that the SEV process is an additional scheme to assist the GPS signal acquisition process in low received power signal detection, without changing the original signal acquisition or tracking algorithms.

Biomedical signal and image processing

CERN Document Server

Najarian, Kayvan

2012-01-01

INTRODUCTION TO DIGITAL SIGNAL AND IMAGE PROCESSINGSignals and Biomedical Signal ProcessingIntroduction and OverviewWhat is a ""Signal""?Analog, Discrete, and Digital SignalsProcessing and Transformation of SignalsSignal Processing for Feature ExtractionSome Characteristics of Digital ImagesSummaryProblemsFourier TransformIntroduction and OverviewOne-Dimensional Continuous Fourier TransformSampling and NYQUIST RateOne-Dimensional Discrete Fourier TransformTwo-Dimensional Discrete Fourier TransformFilter DesignSummaryProblemsImage Filtering, Enhancement, and RestorationIntroduction and Overview

26 CFR 48.4161(b)-2 - Meaning of terms.

Science.gov (United States)

2010-04-01

... EXCISE TAXES MANUFACTURERS AND RETAILERS EXCISE TAXES Sporting Goods § 48.4161(b)-2 Meaning of terms. (a... with the particular type of arrow shaft. (b) Parts and accessories—(1) In general. “Parts and... attachment to, a bow or arrow of the type described in section 4161(b)(1) and paragraph (a) of this section...

Poisson pre-processing of nonstationary photonic signals: Signals with equality between mean and variance.

Science.gov (United States)

Poplová, Michaela; Sovka, Pavel; Cifra, Michal

2017-01-01

Photonic signals are broadly exploited in communication and sensing and they typically exhibit Poisson-like statistics. In a common scenario where the intensity of the photonic signals is low and one needs to remove a nonstationary trend of the signals for any further analysis, one faces an obstacle: due to the dependence between the mean and variance typical for a Poisson-like process, information about the trend remains in the variance even after the trend has been subtracted, possibly yielding artifactual results in further analyses. Commonly available detrending or normalizing methods cannot cope with this issue. To alleviate this issue we developed a suitable pre-processing method for the signals that originate from a Poisson-like process. In this paper, a Poisson pre-processing method for nonstationary time series with Poisson distribution is developed and tested on computer-generated model data and experimental data of chemiluminescence from human neutrophils and mung seeds. The presented method transforms a nonstationary Poisson signal into a stationary signal with a Poisson distribution while preserving the type of photocount distribution and phase-space structure of the signal. The importance of the suggested pre-processing method is shown in Fano factor and Hurst exponent analysis of both computer-generated model signals and experimental photonic signals. It is demonstrated that our pre-processing method is superior to standard detrending-based methods whenever further signal analysis is sensitive to variance of the signal.

Multi-Modal Intelligent Traffic Signal Systems Signal Plans for Roadside Equipment

Data.gov (United States)

Department of Transportation — Data were collected during the Multi-Modal Intelligent Transportation Signal Systems (MMITSS) study. MMITSS is a next-generation traffic signal system that seeks to...

All-optical signal processing of OTDM and OFDM signals based on time-domain Optical Fourier Transformation

DEFF Research Database (Denmark)

Clausen, Anders; Guan, Pengyu; Mulvad, Hans Christian Hansen

2014-01-01

All-optical time-domain Optical Fourier Transformation utilised for signal processing of ultra-high-speed OTDM signals and OFDM signals will be presented.......All-optical time-domain Optical Fourier Transformation utilised for signal processing of ultra-high-speed OTDM signals and OFDM signals will be presented....

Multiscale Signal Analysis and Modeling

CERN Document Server

Zayed, Ahmed

2013-01-01

Multiscale Signal Analysis and Modeling presents recent advances in multiscale analysis and modeling using wavelets and other systems. This book also presents applications in digital signal processing using sampling theory and techniques from various function spaces, filter design, feature extraction and classification, signal and image representation/transmission, coding, nonparametric statistical signal processing, and statistical learning theory. This book also: Discusses recently developed signal modeling techniques, such as the multiscale method for complex time series modeling, multiscale positive density estimations, Bayesian Shrinkage Strategies, and algorithms for data adaptive statistics Introduces new sampling algorithms for multidimensional signal processing Provides comprehensive coverage of wavelets with presentations on waveform design and modeling, wavelet analysis of ECG signals and wavelet filters Reviews features extraction and classification algorithms for multiscale signal and image proce...

Two-dimensional signal analysis

CERN Document Server

Garello, René

2010-01-01

This title sets out to show that 2-D signal analysis has its own role to play alongside signal processing and image processing.Concentrating its coverage on those 2-D signals coming from physical sensors (such as radars and sonars), the discussion explores a 2-D spectral approach but develops the modeling of 2-D signals and proposes several data-oriented analysis techniques for dealing with them. Coverage is also given to potential future developments in this area.

Traffic signal synchronization.

Science.gov (United States)

Huang, Ding-wei; Huang, Wei-neng

2003-05-01

The benefits of traffic signal synchronization are examined within the cellular automata approach. The microsimulations of traffic flow are obtained with different settings of signal period T and time delay delta. Both numerical results and analytical approximations are presented. For undersaturated traffic, the green-light wave solutions can be realized. For saturated traffic, the correlation among the traffic signals has no effect on the throughput. For oversaturated traffic, the benefits of synchronization are manifest only when stochastic noise is suppressed.

Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing

Directory of Open Access Journals (Sweden)

Andre Terzic

2009-04-01

Full Text Available Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring system which reads the cellular energy state in order to tune and report signals to metabolic sensors. A network of adenylate kinase isoforms (AK1-AK7 are distributed throughout intracellular compartments, interstitial space and body fluids to regulate energetic and metabolic signaling circuits, securing efficient cell energy economy, signal communication and stress response. The dynamics of adenylate kinase-catalyzed phosphotransfer regulates multiple intracellular and extracellular energy-dependent and nucleotide signaling processes, including excitation-contraction coupling, hormone secretion, cell and ciliary motility, nuclear transport, energetics of cell cycle, DNA synthesis and repair, and developmental programming. Metabolomic analyses indicate that cellular, interstitial and blood AMP levels are potential metabolic signals associated with vital functions including body energy sensing, sleep, hibernation and food intake. Either low or excess AMP signaling has been linked to human disease such as diabetes, obesity and hypertrophic cardiomyopathy. Recent studies indicate that derangements in adenylate kinase-mediated energetic signaling due to mutations in AK1, AK2 or AK7 isoforms are associated with hemolytic anemia, reticular dysgenesis and ciliary dyskinesia. Moreover, hormonal, food and antidiabetic drug actions are frequently coupled to alterations of cellular AMP levels and associated signaling. Thus, by monitoring energy state and generating and distributing AMP metabolic signals adenylate kinase represents a unique hub within the cellular homeostatic network.

SignalGuru: Leveraging mobile phones for collaborative traffic signal schedule advisory

OpenAIRE

Koukoumidis, Emmanouil; Peh, Li-Shiuan; Martonosi, Margaret

2011-01-01

While traffic signals are necessary to safely control competing flows of traffic, they inevitably enforce a stop-and-go movement pattern that increases fuel consumption, reduces traffic flow and causes traffic jams. These side effects can be alleviated by providing drivers and their onboard computational devices (e.g., vehicle computer, smartphone) with information about the schedule of the traffic signals ahead. Based on when the signal ahead will turn green, drivers can then adjust speed so...

Topological signal processing

CERN Document Server

Robinson, Michael

2014-01-01

Signal processing is the discipline of extracting information from collections of measurements. To be effective, the measurements must be organized and then filtered, detected, or transformed to expose the desired information.  Distortions caused by uncertainty, noise, and clutter degrade the performance of practical signal processing systems. In aggressively uncertain situations, the full truth about an underlying signal cannot be known.  This book develops the theory and practice of signal processing systems for these situations that extract useful, qualitative information using the mathematics of topology -- the study of spaces under continuous transformations.  Since the collection of continuous transformations is large and varied, tools which are topologically-motivated are automatically insensitive to substantial distortion. The target audience comprises practitioners as well as researchers, but the book may also be beneficial for graduate students.

The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals

Science.gov (United States)

Wu, Nan; Nguyen, Quy; Wan, Ying; Zhou, Tiaohao; Venter, Julie; Frampton, Gabriel A; DeMorrow, Sharon; Pan, Duojia; Meng, Fanyin; Glaser, Shannon; Alpini, Gianfranco; Bai, Haibo

2018-01-01

The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that the Notch signaling receptor Notch2 is a direct transcriptional target of the Hippo signaling pathway effector YAP, and the Notch signaling is a major mediator of the Hippo signaling in maintaining biliary cell characteristics in adult mice. However, it remains to be determined whether the Hippo signaling pathway functions through the Notch signaling in intrahepatic bile duct development. We found that loss of the Hippo signaling pathway tumor suppressor Nf2 resulted in increased expression levels of the Notch signaling pathway receptor Notch2 in cholangiocytes but not in hepatocytes. When knocking down Notch2 on the background of Nf2 deficiency in mouse livers, the excessive bile duct development induced by Nf2 deficiency was suppressed by heterozygous and homozygous deletion of Notch2 in a dose-dependent manner. These results implicated that Notch signaling is one of the downstream effectors of the Hippo signaling pathway in regulating intrahepatic bile duct development. PMID:28581486

Biological signals classification and analysis

CERN Document Server

Kiasaleh, Kamran

2015-01-01

This authored monograph presents key aspects of signal processing analysis in the biomedical arena. Unlike wireless communication systems, biological entities produce signals with underlying nonlinear, chaotic nature that elude classification using the standard signal processing techniques, which have been developed over the past several decades for dealing primarily with standard communication systems. This book separates what is random from that which appears to be random, and yet is truly deterministic with random appearance. At its core, this work gives the reader a perspective on biomedical signals and the means to classify and process such signals. In particular, a review of random processes along with means to assess the behavior of random signals is also provided. The book also includes a general discussion of biological signals in order to demonstrate the inefficacy of the well-known techniques to correctly extract meaningful information from such signals. Finally, a thorough discussion of recently ...

Acoustic Signals and Systems

DEFF Research Database (Denmark)

2008-01-01

The Handbook of Signal Processing in Acoustics will compile the techniques and applications of signal processing as they are used in the many varied areas of Acoustics. The Handbook will emphasize the interdisciplinary nature of signal processing in acoustics. Each Section of the Handbook...... will present topics on signal processing which are important in a specific area of acoustics. These will be of interest to specialists in these areas because they will be presented from their technical perspective, rather than a generic engineering approach to signal processing. Non-specialists, or specialists...... from different areas, will find the self-contained chapters accessible and will be interested in the similarities and differences between the approaches and techniques used in different areas of acoustics....

The Signal Validation method of Digital Process Instrumentation System on signal conditioner for SMART

International Nuclear Information System (INIS)

Moon, Hee Gun; Park, Sang Min; Kim, Jung Seon; Shon, Chang Ho; Park, Heui Youn; Koo, In Soo

2005-01-01

The function of PIS(Process Instrumentation System) for SMART is to acquire the process data from sensor or transmitter. The PIS consists of signal conditioner, A/D converter, DSP(Digital Signal Process) and NIC(Network Interface Card). So, It is fully digital system after A/D converter. The PI cabinet and PDAS(Plant Data Acquisition System) in commercial plant is responsible for data acquisition of the sensor or transmitter include RTD, TC, level, flow, pressure and so on. The PDAS has the software that processes each sensor data and PI cabinet has the signal conditioner, which is need for maintenance and test. The signal conditioner has the potentiometer to adjust the span and zero for test and maintenance. The PIS of SMART also has the signal conditioner which has the span and zero adjust same as the commercial plant because the signal conditioner perform the signal condition for AD converter such as 0∼10Vdc. But, To adjust span and zero is manual test and calibration. So, This paper presents the method of signal validation and calibration, which is used by digital feature in SMART. There are I/E(current to voltage), R/E(resistor to voltage), F/E(frequency to voltage), V/V(voltage to voltage). Etc. In this paper show only the signal validation and calibration about I/E converter that convert level, pressure, flow such as 4∼20mA into signal for AD conversion such as 0∼10Vdc

SignalR blueprints

CERN Document Server

Ingebrigtsen, Einar

2015-01-01

This book is designed for software developers, primarily those with knowledge of C#, .NET, and JavaScript. Good knowledge and understanding of SignalR is assumed to allow efficient programming of core elements and applications in SignalR.

Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

Science.gov (United States)

Brandt, Benjamin; Munemasa, Shintaro; Wang, Cun; Nguyen, Desiree; Yong, Taiming; Yang, Paul G; Poretsky, Elly; Belknap, Thomas F; Waadt, Rainer; Alemán, Fernando; Schroeder, Julian I

2015-01-01

A central question is how specificity in cellular responses to the eukaryotic second messenger Ca2+ is achieved. Plant guard cells, that form stomatal pores for gas exchange, provide a powerful system for in depth investigation of Ca2+-signaling specificity in plants. In intact guard cells, abscisic acid (ABA) enhances (primes) the Ca2+-sensitivity of downstream signaling events that result in activation of S-type anion channels during stomatal closure, providing a specificity mechanism in Ca2+-signaling. However, the underlying genetic and biochemical mechanisms remain unknown. Here we show impairment of ABA signal transduction in stomata of calcium-dependent protein kinase quadruple mutant plants. Interestingly, protein phosphatase 2Cs prevent non-specific Ca2+-signaling. Moreover, we demonstrate an unexpected interdependence of the Ca2+-dependent and Ca2+-independent ABA-signaling branches and the in planta requirement of simultaneous phosphorylation at two key phosphorylation sites in SLAC1. We identify novel mechanisms ensuring specificity and robustness within stomatal Ca2+-signaling on a cellular, genetic, and biochemical level. DOI: http://dx.doi.org/10.7554/eLife.03599.001 PMID:26192964

Seismic signals hard clipping overcoming

Science.gov (United States)

Olszowa, Paula; Sokolowski, Jakub

2018-01-01

In signal processing the clipping is understand as the phenomenon of limiting the signal beyond certain threshold. It is often related to overloading of a sensor. Two particular types of clipping are being recognized: soft and hard. Beyond the limiting value soft clipping reduces the signal real gain while the hard clipping stiffly sets the signal values at the limit. In both cases certain amount of signal information is lost. Obviously if one possess the model which describes the considered signal and the threshold value (which might be slightly more difficult to obtain in the soft clipping case), the attempt of restoring the signal can be made. Commonly it is assumed that the seismic signals take form of an impulse response of some specific system. This may lead to belief that the sine wave may be the most appropriate to fit in the clipping period. However, this should be tested. In this paper the possibility of overcoming the hard clipping in seismic signals originating from a geoseismic station belonging to an underground mine is considered. A set of raw signals will be hard-clipped manually and then couple different functions will be fitted and compared in terms of least squares. The results will be then analysed.

Signals in Science - On the Importance of Signaling in Gaining Attention in Science

NARCIS (Netherlands)

H.P. van Dalen (Hendrik); K. Henkens

2004-01-01

textabstractWhich signals are important in gaining attention in science? For a group of 1,371 scientific articles published in 17 demography journals in the years 1990-1992 we track their influence and discern which signals are important in receiving citations. Three types of signals are examined:

Signal flow analysis

CERN Document Server

Abrahams, J R; Hiller, N

1965-01-01

Signal Flow Analysis provides information pertinent to the fundamental aspects of signal flow analysis. This book discusses the basic theory of signal flow graphs and shows their relation to the usual algebraic equations.Organized into seven chapters, this book begins with an overview of properties of a flow graph. This text then demonstrates how flow graphs can be applied to a wide range of electrical circuits that do not involve amplification. Other chapters deal with the parameters as well as circuit applications of transistors. This book discusses as well the variety of circuits using ther

Measuring displacement signal with an accelerometer

International Nuclear Information System (INIS)

Han, Sang Bo

2010-01-01

An effective and simple way to reconstruct displacement signal from a measured acceleration signal is proposed in this paper. To reconstruct displacement signal by means of double-integrating the time domain acceleration signal, the Nyquist frequency of the digital sampling of the acceleration signal should be much higher than the highest frequency component of the signal. On the other hand, to reconstruct displacement signal by taking the inverse Fourier transform, the magnitude of the significant frequency components of the Fourier transform of the acceleration signal should be greater than the 6 dB increment line along the frequency axis. With a predetermined resolution in time and frequency domain, determined by the sampling rate to measure and record the original signal, reconstructing high-frequency signals in the time domain and reconstructing low-frequency signals in the frequency domain will produce biased errors. Furthermore, because of the DC components inevitably included in the sampling process, low-frequency components of the signals are overestimated when displacement signals are reconstructed from the Fourier transform of the acceleration signal. The proposed method utilizes curve-fitting around the significant frequency components of the Fourier transform of the acceleration signal before it is inverse-Fourier transformed. Curve-fitting around the dominant frequency components provides much better results than simply ignoring the insignificant frequency components of the signal

Arrow injuries to the eye

African Journals Online (AJOL)

There was positive history of application of traditional eye medicine and an unsuccessful attempt was made ... in the dry season in the northern parts of Nigeria, ... Hematocrit, serum urea and electrolytes were within normal limits. Treatment.

Breaking the arrows of causality

DEFF Research Database (Denmark)

Valsiner, Jaan

2014-01-01

role of cyclical models in biology has made it possible to move from the idea of genetic determination to that of epigenetic negotiation as the core of biological theory. In psychology, catalytic thinking has been outside of the realm of accepted scientific schemes, as the axiomatic dependence upon...

Episensitization: Defying Time’s Arrow

Directory of Open Access Journals (Sweden)

Bryan eOronsky

2015-06-01

Full Text Available The development of cancer is driven by complex genetic and epigenetic changes that result in aberrant and uncontrolled cellular growth. Epigenetic changes, in particular, are implicated in the silencing or activation of key genes that control cellular growth and apoptosis and contribute to transformative potential. The purpose of this review is to define and assess the treatment strategy of episensitization, or the ability to sensitize cancer cells to subsequent therapy by resetting the epigenetic infrastructure of the tumor. One important facet is resensitization by epigenetic mechanisms, which goes against the norm, i.e., challenges the long-held doctrine in oncology that the reuse of previously tried and failed therapies is a clinically pointless endeavor. Thus, episensitization is a hybrid term, which covers recent clinically relevant observations and refers to the epigenomic mechanism of resensitization. Among the many formidable challenges in the treatment of cancer, the most inevitable is the development of acquired therapeutic resistance. Here, we present the basic principles behind episensitization and highlight the evidence suggesting that epigenetically mediated histone hypoacetylation and DNA hypermethylation events may reverse clinical drug resistance. The potential reversibility of epigenetic changes and the microenvironmental impact of epigenetic control on gene expression may mediate a return to a baseline state of treatment susceptibility. Episensitization is a novel and highly practical management strategy both to prevent the practice of permanent treatment discontinuation with the occurrence of resistance, which rapidly exhausts remaining options in the pharmaceutical armamentarium and to significantly extend patient survival. Accordingly, this review highlights several epigenetic agents including decitabine, vorinostat, entinostat, 5-azacitidine, oncolytic viruses and RRx-001.

A measurement of the branching ratio of K± →π±μ+μ- decays in the Hyper CP experiment

International Nuclear Information System (INIS)

Zyla, Piotr

2001-01-01

Large samples of hyperon and kaon decays were collected with the Hyper CP spectrometer during two fixed-target runs at Fermilab. Based on an analysis of 110 million K pm decays from the 1997 data sample we present a branching ratio for K pm right arrow pi pm mu+ mu-. This is the first observation of K- right arrow pi- mu+ mu- decay

Biomedical signals and systems

CERN Document Server

Tranquillo, Joseph V

2013-01-01

Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

Photoacoustic signal and noise analysis for Si thin plate: signal correction in frequency domain.

Science.gov (United States)

Markushev, D D; Rabasović, M D; Todorović, D M; Galović, S; Bialkowski, S E

2015-03-01

Methods for photoacoustic signal measurement, rectification, and analysis for 85 μm thin Si samples in the 20-20 000 Hz modulation frequency range are presented. Methods for frequency-dependent amplitude and phase signal rectification in the presence of coherent and incoherent noise as well as distortion due to microphone characteristics are presented. Signal correction is accomplished using inverse system response functions deduced by comparing real to ideal signals for a sample with well-known bulk parameters and dimensions. The system response is a piece-wise construction, each component being due to a particular effect of the measurement system. Heat transfer and elastic effects are modeled using standard Rosencweig-Gersho and elastic-bending theories. Thermal diffusion, thermoelastic, and plasmaelastic signal components are calculated and compared to measurements. The differences between theory and experiment are used to detect and correct signal distortion and to determine detector and sound-card characteristics. Corrected signal analysis is found to faithfully reflect known sample parameters.

Wavelet analysis for nonstationary signals

International Nuclear Information System (INIS)

Penha, Rosani Maria Libardi da

1999-01-01

Mechanical vibration signals play an important role in anomalies identification resulting of equipment malfunctioning. Traditionally, Fourier spectral analysis is used where the signals are assumed to be stationary. However, occasional transient impulses and start-up process are examples of nonstationary signals that can be found in mechanical vibrations. These signals can provide important information about the equipment condition, as early fault detection. The Fourier analysis can not adequately be applied to nonstationary signals because the results provide data about the frequency composition averaged over the duration of the signal. In this work, two methods for nonstationary signal analysis are used: Short Time Fourier Transform (STFT) and wavelet transform. The STFT is a method of adapting Fourier spectral analysis for nonstationary application to time-frequency domain. To have a unique resolution throughout the entire time-frequency domain is its main limitation. The wavelet transform is a new analysis technique suitable to nonstationary signals, which handles the STFT drawbacks, providing multi-resolution frequency analysis and time localization in a unique time-scale graphic. The multiple frequency resolutions are obtained by scaling (dilatation/compression) the wavelet function. A comparison of the conventional Fourier transform, STFT and wavelet transform is made applying these techniques to: simulated signals, arrangement rotor rig vibration signal and rotate machine vibration signal Hanning window was used to STFT analysis. Daubechies and harmonic wavelets were used to continuos, discrete and multi-resolution wavelet analysis. The results show the Fourier analysis was not able to detect changes in the signal frequencies or discontinuities. The STFT analysis detected the changes in the signal frequencies, but with time-frequency resolution problems. The wavelet continuos and discrete transform demonstrated to be a high efficient tool to detect

Search for {phi} mesons in {tau} lepton decay

Energy Technology Data Exchange (ETDEWEB)

Avery, P.; Prescott, C.; Yang, S.; Yelton, J. [University of Florida, Gainesville, Florida 32611 (United States); Brandenburg, G.; Briere, R.A.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H. [Harvard University, Cambridge, Massachusetts 02138 (United States); Browder, T.E.; Li, F.; Rodriguez, J.L. [University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Karliner, I.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Champaign-Urbana, Illinois 61801 (United States); Edwards, K.W.; Ogg, M. [Carleton University, Ottawa, Ontario, K1S 5B6 (CANADA); Bellerive, A.; Britton, D.I.; Janicek, R.; MacFarlane, D.B.; McLean, K.W.; Patel, P.M. [McGill University, Montreal, Quebec, H3A 2T8 (CANADA); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lattery, M.; ONeill, J.J.; Patton, S.; Poling, R.; Riehle, T.; Smith, A.; Savinov, V. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Duboscq, J.E.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; Undrus, A.; White, C.; Wanke, R.; Wolf, A.; Zoeller, M.M. [Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P.; Wood, M. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Johnson, S.D.

1997-02-01

We report results from a direct search for {tau}{sup {minus}}{r_arrow}{phi}h{sup {minus}}{nu}{sub {tau}}(h{sup {minus}}={pi}{sup {minus}}or K{sup {minus}}) using 3.1 fb{sup {minus}1} of data collected with the CLEO II detector. We find model-dependent upper limits on the branching fractions in the range B({tau}{sup {minus}}{r_arrow}{phi}{pi}{sup {minus}}{nu}{sub {tau}}){lt}(1.2{minus}2.0){times}10{sup {minus}4} and B({tau}{sup {minus}}{r_arrow}{phi}K{sup {minus}}{nu}{sub {tau}}){lt}(5.4{minus}6.7){times}10{sup {minus}5} at 90{percent} confidence level. {copyright} {ital 1997} {ital The American Physical Society}

Critical nodes in signalling pathways

DEFF Research Database (Denmark)

Taniguchi, Cullen M; Emanuelli, Brice; Kahn, C Ronald

2006-01-01

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role...... using insulin signalling as a model system....

The Evolution of Covert Signaling.

Science.gov (United States)

Smaldino, Paul E; Flamson, Thomas J; McElreath, Richard

2018-03-20

Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberately ambiguous signals: covert signaling. Covert signaling is the transmission of information that is accurately received by its intended audience but obscured when perceived by others. Such signals may allow coordination and enhanced cooperation while also avoiding the alienation or hostile reactions of individuals with different preferences. Although the empirical literature has identified potential mechanisms of covert signaling, such as encryption in humor, there is to date no formal theory of its dynamics. We introduce a novel mathematical model to assess when a covert signaling strategy will evolve, as well as how receiver attitudes coevolve with covert signals. Covert signaling plausibly serves an important function in facilitating within-group cooperative assortment by allowing individuals to pair up with similar group members when possible and to get along with dissimilar ones when necessary. This mechanism has broad implications for theories of signaling and cooperation, humor, social identity, political psychology, and the evolution of human cultural complexity.

Signal multiplexing scheme for LINAC

International Nuclear Information System (INIS)

Sujo, C.I.; Mohan, Shyam; Joshi, Gopal; Singh, S.K.; Karande, Jitendra

2004-01-01

For the proper operation of the LINAC some signals, RF (radio frequency) as well as LF (low frequency) have to be available at the Master Control Station (MCS). These signals are needed to control, calibrate and characterize the RF fields in the resonators. This can be achieved by proper multiplexing of various signals locally and then routing the selected signals to the MCS. A multiplexing scheme has been designed and implemented, which will allow the signals from the selected cavity to the MCS. High isolation between channels and low insertion loss for a given signal are important issues while selecting the multiplexing scheme. (author)

Signal Separation of Helicopter Radar Returns Using Wavelet-Based Sparse Signal Optimisation

Science.gov (United States)

2016-10-01

helicopter from the composite radar returns. The received signal consists of returns from the rotating main and tail rotor blades, the helicopter body...is used to separate the main and tail rotor blade components of a helicopter from the composite radar returns. The received signal consists of returns...Two algorithms are presented in the report to separately extract main rotor blade returns and tail rotor blade returns from the composite signal

Signals and systems

CERN Document Server

Rao, K Deergha

2018-01-01

This textbook covers the fundamental theories of signals and systems analysis, while incorporating recent developments from integrated circuits technology into its examples. Starting with basic definitions in signal theory, the text explains the properties of continuous-time and discrete-time systems and their representation by differential equations and state space. From those tools, explanations for the processes of Fourier analysis, the Laplace transform, and the z-Transform provide new ways of experimenting with different kinds of time systems. The text also covers the separate classes of analog filters and their uses in signal processing applications. Intended for undergraduate electrical engineering students, chapter sections include exercise for review and practice for the systems concepts of each chapter. Along with exercises, the text includes MATLAB-based examples to allow readers to experiment with signals and systems code on their own. An online repository of the MATLAB code from this textbook can...

Phantom phone signals: An investigation into the prevalence and predictors of imagined cell phone signals

NARCIS (Netherlands)

Tanis, M.A.; Beukeboom, C.J.; Hartmann, T.; Vermeulen, I.E.

2015-01-01

This paper aims to elucidate the peculiar phenomenon of imagined cell phone signals, or Phantom Phone Signals (PPS), which is defined as an individual's perception of a phone signal, indicating an incoming call, message, or social media notification, when in fact no such signal was transmitted. A

Radiation signal processing system

International Nuclear Information System (INIS)

Bennett, M.; Knoll, G.; Strange, D.

1980-01-01

An improved signal processing system for radiation imaging apparatus comprises: a radiation transducer producing transducer signals proportional to apparent spatial coordinates of detected radiation events; means for storing true spatial coordinates corresponding to a plurality of predetermined apparent spatial coordinates relative to selected detected radiation events said means for storing responsive to said transducer signal and producing an output signal representative of said true spatial coordinates; and means for interpolating the true spatial coordinates of the detected radiation events located intermediate the stored true spatial coordinates, said means for interpolating communicating with said means for storing

Signal sampling circuit

NARCIS (Netherlands)

Louwsma, S.M.; Vertregt, Maarten

2011-01-01

A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital

Signal sampling circuit

NARCIS (Netherlands)

Louwsma, S.M.; Vertregt, Maarten

2010-01-01

A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital

Bioelectric Signal Measuring System

Science.gov (United States)

Guadarrama-Santana, A.; Pólo-Parada, L.; García-Valenzuela, A.

2015-01-01

We describe a low noise measuring system based on interdigitated electrodes for sensing bioelectrical signals. The system registers differential voltage measurements in order of microvolts. The base noise during measurements was in nanovolts and thus, the sensing signals presented a very good signal to noise ratio. An excitation voltage of 1Vrms with 10 KHz frequency was applied to an interdigitated capacitive sensor without a material under test and to a mirror device simultaneously. The output signals of both devices was then subtracted in order to obtain an initial reference value near cero volts and reduce parasitic capacitances due to the electronics, wiring and system hardware as well. The response of the measuring system was characterized by monitoring temporal bioelectrical signals in real time of biological materials such as embryo chicken heart cells and bovine suprarenal gland cells.

Coupled sulfur isotopic and chemical mass transfer modeling: Approach and application to dynamic hydrothermal processes

International Nuclear Information System (INIS)

Janecky, D.R.

1988-01-01

A computational modeling code (EQPSreverse arrowS) has been developed to examine sulfur isotopic distribution pathways coupled with calculations of chemical mass transfer pathways. A post processor approach to EQ6 calculations was chosen so that a variety of isotopic pathways could be examined for each reaction pathway. Two types of major bounding conditions were implemented: (1) equilibrium isotopic exchange between sulfate and sulfide species or exchange only accompanying chemical reduction and oxidation events, and (2) existence or lack of isotopic exchange between solution species and precipitated minerals, parallel to the open and closed chemical system formulations of chemical mass transfer modeling codes. All of the chemical data necessary to explicitly calculate isotopic distribution pathways is generated by most mass transfer modeling codes and can be input to the EQPS code. Routines are built in to directly handle EQ6 tabular files. Chemical reaction models of seafloor hydrothermal vent processes and accompanying sulfur isotopic distribution pathways illustrate the capabilities of coupling EQPSreverse arrowS with EQ6 calculations, including the extent of differences that can exist due to the isotopic bounding condition assumptions described above. 11 refs., 2 figs

Signal interaction of Hedgehog/GLI and epidermal growth factor receptor signaling in cancer development

International Nuclear Information System (INIS)

Eberl, M.

2012-01-01

The subject of this PhD thesis is based on the cooperation of Hedgehog (HH)/GLI with epidermal growth factor receptor (EGFR) signaling synergistically promoting oncogenic transformation and cancer growth. In previous studies we have demonstrated that the HH/GLI and EGFR signaling pathways interact synergistically resulting not only in selective induction of HH/GLI-EGFR target genes, but also in the onset of oncogenic transformation and tumor formation (Kasper, Schnidar et al. 2006; Schnidar, Eberl et al. 2009). However, the molecular key mediators acting downstream of HH/GLI and EGFR signal cooperation were largely unknown and the in vivo evidence for the therapeutic relevance of HH/GLI and EGFR signal cooperation in HH-associated cancers was lacking. During my PhD thesis I could demonstrate that the integration of EGFR and HH/GLI signaling involves activation of RAS/MEK/ERK and JUN/AP1 signaling in response to EGFR activation. Furthermore I succeeded in identifying genes, including stem cell- (SOX2, SOX9), tumor growth- (JUN, TGFA, FGF19) and metastasis-associated genes (SPP1/osteopontin, CXCR4) that showed synergistic transcriptional activation by HH/GLI-EGFR signal integration. Importantly, I could demonstrate that these genes arrange themselves within a stable interdependent signaling network, which is required for in vivo growth of basal cell carcinoma (BCC) and tumor-initiating pancreatic cancer cells. These data validate EGFR signaling as additional drug target in HH/GLI driven cancers and provide new therapeutic strategies based on combined targeting of cooperative HH/GLI-EGFR signaling and selected downstream target genes (Eberl, Klingler et al. 2012). (author) [de

Advanced optical signal processing of broadband parallel data signals

DEFF Research Database (Denmark)

Oxenløwe, Leif Katsuo; Hu, Hao; Kjøller, Niels-Kristian

2016-01-01

Optical signal processing may aid in reducing the number of active components in communication systems with many parallel channels, by e.g. using telescopic time lens arrangements to perform format conversion and allow for WDM regeneration.......Optical signal processing may aid in reducing the number of active components in communication systems with many parallel channels, by e.g. using telescopic time lens arrangements to perform format conversion and allow for WDM regeneration....

Detection of signals in noise

CERN Document Server

Whalen, Anthony D; Declaris, Nicholas

1971-01-01

Detection of Signals in Noise serves as an introduction to the principles and applications of the statistical theory of signal detection. The book discusses probability and random processes; narrowband signals, their complex representation, and their properties described with the aid of the Hilbert transform; and Gaussian-derived processes. The text also describes the application of hypothesis testing for the detection of signals and the fundamentals required for statistical detection of signals in noise. Problem exercises, references, and a supplementary bibliography are included after each c

Paracrine signaling in a bacterium.

Science.gov (United States)

López, Daniel; Vlamakis, Hera; Losick, Richard; Kolter, Roberto

2009-07-15

Cellular differentiation is triggered by extracellular signals that cause target cells to adopt a particular fate. Differentiation in bacteria typically involves autocrine signaling in which all cells in the population produce and respond to the same signal. Here we present evidence for paracrine signaling in bacterial populations-some cells produce a signal to which only certain target cells respond. Biofilm formation in Bacillus involves two centrally important signaling molecules, ComX and surfactin. ComX triggers the production of surfactin. In turn, surfactin causes a subpopulation of cells to produce an extracellular matrix. Cells that produced surfactin were themselves unable to respond to it. Likewise, once surfactin-responsive cells commenced matrix production, they no longer responded to ComX and could not become surfactin producers. Insensitivity to ComX was the consequence of the extracellular matrix as mutant cells unable to make matrix responded to both ComX and surfactin. Our results demonstrate that extracellular signaling was unidirectional, with one subpopulation producing a signal and a different subpopulation responding to it. Paracrine signaling in a bacterial population ensures the maintenance, over generations, of particular cell types even in the presence of molecules that would otherwise cause those cells to differentiate into other cell types.

Machine intelligence and signal processing

CERN Document Server

Vatsa, Mayank; Majumdar, Angshul; Kumar, Ajay

2016-01-01

This book comprises chapters on key problems in machine learning and signal processing arenas. The contents of the book are a result of a 2014 Workshop on Machine Intelligence and Signal Processing held at the Indraprastha Institute of Information Technology. Traditionally, signal processing and machine learning were considered to be separate areas of research. However in recent times the two communities are getting closer. In a very abstract fashion, signal processing is the study of operator design. The contributions of signal processing had been to device operators for restoration, compression, etc. Applied Mathematicians were more interested in operator analysis. Nowadays signal processing research is gravitating towards operator learning – instead of designing operators based on heuristics (for example wavelets), the trend is to learn these operators (for example dictionary learning). And thus, the gap between signal processing and machine learning is fast converging. The 2014 Workshop on Machine Intel...

Signals and systems for dummies

CERN Document Server

Wickert, Mark

2013-01-01

Getting mixed signals in your signals and systems course? The concepts covered in a typical signals and systems course are often considered by engineering students to be some of the most difficult to master. Thankfully, Signals & Systems For Dummies is your intuitive guide to this tricky course, walking you step-by-step through some of the more complex theories and mathematical formulas in a way that is easy to understand. From Laplace Transforms to Fourier Analyses, Signals & Systems For Dummies explains in plain English the difficult concepts that can trip you up

Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72

Energy Technology Data Exchange (ETDEWEB)

Ham, Young-Mi, E-mail: youngmi_ham@hms.harvard.edu [College of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States); Mahoney, Sarah Jane [Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States)

2013-06-10

The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-α, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors.

Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72

International Nuclear Information System (INIS)

Ham, Young-Mi; Mahoney, Sarah Jane

2013-01-01

The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-α, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors

Emotion potentiates response activation and inhibition in masked priming.

Science.gov (United States)

Bocanegra, Bruno R; Zeelenberg, René

2012-01-01

Previous studies have shown that emotion can have 2-fold effects on perception. At the object-level, emotional stimuli benefit from a stimulus-specific boost in visual attention at the relative expense of competing stimuli. At the visual feature-level, recent findings indicate that emotion may inhibit the processing of small visual details and facilitate the processing of coarse visual features. In the present study, we investigated whether emotion can boost the activation and inhibition of automatic motor responses that are generated prior to overt perception. To investigate this, we tested whether an emotional cue affects covert motor responses in a masked priming task. We used a masked priming paradigm in which participants responded to target arrows that were preceded by invisible congruent or incongruent prime arrows. In the standard paradigm, participants react faster, and commit fewer errors responding to the directionality of target arrows, when they are preceded by congruent vs. incongruent masked prime arrows (positive congruency effect, PCE). However, as prime-target SOAs increase, this effect reverses (negative congruency effect, NCE). These findings have been explained as evidence for an initial activation and a subsequent inhibition of a partial response elicited by the masked prime arrow. Our results show that the presentation of fearful face cues, compared to neutral face cues, increased the size of both the PCE and NCE, despite the fact that the primes were invisible. This is the first demonstration that emotion prepares an individual's visuomotor system for automatic activation and inhibition of motor responses in the absence of visual awareness.

Multimodal signalling in estrildid finches

DEFF Research Database (Denmark)

Gomes, A. C. R.; Funghi, C.; Soma, M.

2017-01-01

Sexual traits (e.g. visual ornaments, acoustic signals, courtship behaviour) are often displayed together as multimodal signals. Some hypotheses predict joint evolution of different sexual signals (e.g. to increase the efficiency of communication) or that different signals trade off with each other...... (e.g. due to limited resources). Alternatively, multiple signals may evolve independently for different functions, or to communicate different information (multiple message hypothesis). We evaluated these hypotheses with a comparative study in the family Estrildidae, one of the largest songbird...... compromise, but generally courtship dance also evolved independently from other signals. Instead of correlated evolution, we found that song, dance and colour are each related to different socio-ecological traits. Song complexity evolved together with ecological generalism, song performance with investment...

Probability of stochastic processes and spacetime geometry

International Nuclear Information System (INIS)

Canessa, E.

2007-01-01

We made a first attempt to associate a probabilistic description of stochastic processes like birth-death processes with spacetime geometry in the Schwarzschild metrics on distance scales from the macro- to the micro-domains. We idealize an ergodic system in which system states communicate through a curved path composed of transition arrows where each arrow corresponds to a positive, analogous birth or death rate. (author)

Sagitta

Science.gov (United States)

Murdin, P.

2000-11-01

(the Arrow; abbrev. Sge, gen. Sagittae; area 80 sq. deg.) A northern constellation which lies between Vulpecula and Aquila, and culminates at midnight in mid-July. Its origin dates back at least to ancient Greece, where it was identified (by different authorities) with arrows belonging to Eros, Apollo and Hercules in Greek mythology. The brightest stars of Sagitta were cataloged by Ptolemy (c. AD...

Experiment and practice on signal processing

International Nuclear Information System (INIS)

2002-11-01

The contents of this book contains basic practice of CEM Tool, discrete time signal and experiment and practice of system, experiment and practice of discrete time signal sampling, practice of frequency analysis, experiment of digital filter design, application of digital signal processing, project related voice, basic principle of signal processing, the technique of basic image signal processing, biology astronomy and Robot soccer with apply of image signal processing technique, control video signal and project related image. It also has an introduction of CEM Linker I. O in the end.

Experiment and practice on signal processing

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-11-15

The contents of this book contains basic practice of CEM Tool, discrete time signal and experiment and practice of system, experiment and practice of discrete time signal sampling, practice of frequency analysis, experiment of digital filter design, application of digital signal processing, project related voice, basic principle of signal processing, the technique of basic image signal processing, biology astronomy and Robot soccer with apply of image signal processing technique, control video signal and project related image. It also has an introduction of CEM Linker I. O in the end.

Signal anomaly detection and characterization

International Nuclear Information System (INIS)

Morgenstern, V.M.; Upadhyaya, B.R.; Gloeckler, O.

1988-08-01

As part of a comprehensive signal validation system, we have developed a signal anomaly detector, without specifically establishing the cause of the anomaly. A signal recorded from process instrumentation is said to have an anomaly, if during steady-state operation, the deviation in the level of the signal, its root-mean-square (RMS) value, or its statistical distribution changes by a preset value. This deviation could be an unacceptable increase or a decrease in the quantity being monitored. An anomaly in a signal may be characterized by wideband or single-frequency noise, bias error, pulse-type error, nonsymmetric behavior, or a change in the signal bandwidth. Various signatures can be easily computed from data samples and compared against specified threshold values. We want to point out that in real processes, pulses can appear with different time widths, and at different rates of change of the signal. Thus, in characterizing an anomaly as a pulse-type, the fastest pulse width is constrained by the signal sampling interval. For example, if a signal is sampled at 100 Hz, we will not be able to detect pulses occurring at kHz rates. Discussion with utility and Combustion Engineering personnel indicated that it is not practical to detect pulses having a narrow time width. 9 refs., 11 figs., 8 tabs

Signals, processes, and systems an interactive multimedia introduction to signal processing

CERN Document Server

Karrenberg, Ulrich

2013-01-01

This is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research. The textbook together with the DVD form a learning system that provides investigative studies and enables the reader to interactively visualize even complex processes. The unique didactic concept is built on visualizing signals and processes on the one hand, and on graphical programming of signal processing systems on the other. The concept has been designed especially for microelectronics, computer technology and communication. The book allows to develop, modify, and optimize useful applications using DasyLab - a professional and globally supported software for metrology and control engineering. With the 3rd edition, the software is also suitable for 64 bit systems running on Windows 7. Real signals can be acquired, processed and played on the sound card of your computer. The book provides more than 200 pre-pr...

Sexual signalling in female crested macaques and the evolution of primate fertility signals.

Science.gov (United States)

Higham, James P; Heistermann, Michael; Saggau, Carina; Agil, Muhammad; Perwitasari-Farajallah, Dyah; Engelhardt, Antje

2012-06-18

Female signals of fertility have evolved in diverse taxa. Among the most interesting study systems are those of multimale multifemale group-living primates, where females signal fertility to males through multiple signals, and in which there is substantial inter-specific variation in the composition and reliability of such signals. Among the macaques, some species display reliable behavioural and/or anogenital signals while others do not. One cause of this variation may be differences in male competitive regimes: some species show marked sexual dimorphism and reproductive skew, with males fighting for dominance, while others show low dimorphism and skew, with males queuing for dominance. As such, there is variation in the extent to which rank is a reliable proxy for male competitiveness, which may affect the extent to which it is in females' interest to signal ovulation reliably. However, data on ovulatory signals are absent from species at one end of the macaque continuum, where selection has led to high sexual dimorphism and male reproductive skew. Here we present data from 31 cycles of 19 wild female crested macaques, a highly sexually dimorphic species with strong mating skew. We collected measures of ovarian hormone data from faeces, sexual swelling size from digital images, and male and female behaviour. We show that both sexual swelling size and female proceptivity are graded-signals, but relatively reliable indicators of ovulation, with swelling size largest and female proceptive behaviours most frequent around ovulation. Sexual swelling size was also larger in conceptive cycles. Male mating behaviour was well timed to female ovulation, suggesting that males had accurate information about this. Though probabilistic, crested macaque ovulatory signals are relatively reliable. We argue that in species where males fight over dominance, male dominance rank is surrogate for competitiveness. Under these circumstances it is in the interest of females to increase

Sexual signalling in female crested macaques and the evolution of primate fertility signals

Directory of Open Access Journals (Sweden)

Higham James P

2012-06-01

Full Text Available Abstract Background Female signals of fertility have evolved in diverse taxa. Among the most interesting study systems are those of multimale multifemale group-living primates, where females signal fertility to males through multiple signals, and in which there is substantial inter-specific variation in the composition and reliability of such signals. Among the macaques, some species display reliable behavioural and/or anogenital signals while others do not. One cause of this variation may be differences in male competitive regimes: some species show marked sexual dimorphism and reproductive skew, with males fighting for dominance, while others show low dimorphism and skew, with males queuing for dominance. As such, there is variation in the extent to which rank is a reliable proxy for male competitiveness, which may affect the extent to which it is in females’ interest to signal ovulation reliably. However, data on ovulatory signals are absent from species at one end of the macaque continuum, where selection has led to high sexual dimorphism and male reproductive skew. Here we present data from 31 cycles of 19 wild female crested macaques, a highly sexually dimorphic species with strong mating skew. We collected measures of ovarian hormone data from faeces, sexual swelling size from digital images, and male and female behaviour. Results We show that both sexual swelling size and female proceptivity are graded-signals, but relatively reliable indicators of ovulation, with swelling size largest and female proceptive behaviours most frequent around ovulation. Sexual swelling size was also larger in conceptive cycles. Male mating behaviour was well timed to female ovulation, suggesting that males had accurate information about this. Conclusion Though probabilistic, crested macaque ovulatory signals are relatively reliable. We argue that in species where males fight over dominance, male dominance rank is surrogate for competitiveness. Under these

Molecular and Cellular Signaling

CERN Document Server

Beckerman, Martin

2005-01-01

A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases ...

VLSI signal processing technology

CERN Document Server

Swartzlander, Earl

1994-01-01

This book is the first in a set of forthcoming books focussed on state-of-the-art development in the VLSI Signal Processing area. It is a response to the tremendous research activities taking place in that field. These activities have been driven by two factors: the dramatic increase in demand for high speed signal processing, especially in consumer elec­ tronics, and the evolving microelectronic technologies. The available technology has always been one of the main factors in determining al­ gorithms, architectures, and design strategies to be followed. With every new technology, signal processing systems go through many changes in concepts, design methods, and implementation. The goal of this book is to introduce the reader to the main features of VLSI Signal Processing and the ongoing developments in this area. The focus of this book is on: • Current developments in Digital Signal Processing (DSP) pro­ cessors and architectures - several examples and case studies of existing DSP chips are discussed in...

Zinc Signals and Immunity.

Science.gov (United States)

Maywald, Martina; Wessels, Inga; Rink, Lothar

2017-10-24

Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency as well as zinc excess result in severe disturbances in immune cell numbers and activities, which can result in increased susceptibility to infections and development of especially inflammatory diseases. This review focuses on the role of zinc in regulating intracellular signaling pathways in innate as well as adaptive immune cells. Main underlying molecular mechanisms and targets affected by altered zinc homeostasis, including kinases, caspases, phosphatases, and phosphodiesterases, will be highlighted in this article. In addition, the interplay of zinc homeostasis and the redox metabolism in affecting intracellular signaling will be emphasized. Key signaling pathways will be described in detail for the different cell types of the immune system. In this, effects of fast zinc flux, taking place within a few seconds to minutes will be distinguish from slower types of zinc signals, also designated as "zinc waves", and late homeostatic zinc signals regarding prolonged changes in intracellular zinc.

Cooperative ethylene receptor signaling

OpenAIRE

Liu, Qian; Wen, Chi-Kuang

2012-01-01

The gaseous plant hormone ethylene is perceived by a family of five ethylene receptor members in the dicotyledonous model plant Arabidopsis. Genetic and biochemical studies suggest that the ethylene response is suppressed by ethylene receptor complexes, but the biochemical nature of the receptor signal is unknown. Without appropriate biochemical measures to trace the ethylene receptor signal and quantify the signal strength, the biological significance of the modulation of ethylene responses ...

Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla.

Science.gov (United States)

Sagen, Anne Lise; Gertsch, Jürg; Becker, Rita; Heilmann, Jörg; Sticher, Otto

2002-12-01

The bark of Clathrotropis glaucophylla (Fabaceae) is used as admixture of curare arrow poison by the Yanomami; Amerindians in Venezuela. A new quinolizidine alkaloid (QA), (-)-13alpha-hydroxy-15alpha-(1-hydroxyethyl)-anagyrine [(-)-clathrotropine], was isolated from the alkaloid extract of C. glaucophylla bark, together with eleven known QAs: (-)-anagyrine, (-)-thermopsine, (-)-baptifoline, (-)-epibaptifoline, (-)-rhombifoline, (-)-tinctorine, (-)-cytisine, (-)-N-methylcytisine, (-)-lupanine, (-)-6alpha-hydroxylupanine and (+)-5,6-dehydrolupanine. The isolation and structure elucidation were performed with the aid of chromatographic (TLC, HPLC and CC) and spectroscopic (UV and 1D/2D NMR) methods, and mass spectrometry. To our knowledge, this is the first time quinolizidine alkaloids have been isolated from an arrow poison ingredient. It is also the first report on Clathrotropis species being used for preparation of arrow poison.

Regulator of G-protein signaling - 5 (RGS5 is a novel repressor of hedgehog signaling.

Directory of Open Access Journals (Sweden)

William M Mahoney

Full Text Available Hedgehog (Hh signaling plays fundamental roles in morphogenesis, tissue repair, and human disease. Initiation of Hh signaling is controlled by the interaction of two multipass membrane proteins, patched (Ptc and smoothened (Smo. Recent studies identify Smo as a G-protein coupled receptor (GPCR-like protein that signals through large G-protein complexes which contain the Gαi subunit. We hypothesize Regulator of G-Protein Signaling (RGS proteins, and specifically RGS5, are endogenous repressors of Hh signaling via their ability to act as GTPase activating proteins (GAPs for GTP-bound Gαi, downstream of Smo. In support of this hypothesis, we demonstrate that RGS5 over-expression inhibits sonic hedgehog (Shh-mediated signaling and osteogenesis in C3H10T1/2 cells. Conversely, signaling is potentiated by siRNA-mediated knock-down of RGS5 expression, but not RGS4 expression. Furthermore, using immuohistochemical analysis and co-immunoprecipitation (Co-IP, we demonstrate that RGS5 is present with Smo in primary cilia. This organelle is required for canonical Hh signaling in mammalian cells, and RGS5 is found in a physical complex with Smo in these cells. We therefore conclude that RGS5 is an endogenous regulator of Hh-mediated signaling and that RGS proteins are potential targets for novel therapeutics in Hh-mediated diseases.

Studies on signal validation and sensor surveillance for in-core signals in NPP

International Nuclear Information System (INIS)

Ciftcioglu, O.

1991-12-01

Signal validation and sensor failure detection are two essential tasks to be carried out continuously in an operating reactor. Towards this aim, an optimal filtering approach for in-core NPP signals is implemented. The method concerns the specific measured input signal information as a parameter state and they are estimated by means of Kalman filtering technique. The signal validation and sensor surveillance system comprise filters as many as the states being considered and each filter receives all the measured signals as inputs in such a way that each filter in hand is desensitized to one of the individual input signals relative to others. In case of no failure of sensors all the filter outputs are identical. Each sensor output is tested by means of corresponding estimate present at the output of that filter which is desensitized to the sensor being tested. The comparison test is carried out continuously in real-time and any significant deviation noted during the test process is identified to be a sensor failure together with the faulty sensor. The method is investigated by means of real plant data of the in-core neutron detectors and core-inlet and outlet thermocouples of the Borssele nuclear power plant. The method has proven to be effective for fast and reliable in-core sensor failure detection as well as for in-core signal validation in normal operation indicating its further effectiveness for model validation applications in nuclear power plants. (author). 17 refs.; 4 figs.; 1 tab

Cellular signalling properties in microcircuits

DEFF Research Database (Denmark)

Toledo-Rodriguez, Maria; El Manira, Abdeljabbar; Wallén, Peter

2005-01-01

Molecules and cells are the signalling elements in microcircuits. Recent studies have uncovered bewildering diversity in postsynaptic signalling properties in all areas of the vertebrate nervous system. Major effort is now being invested in establishing the specialized signalling properties...

Ghost signals in Allison emittance scanners

International Nuclear Information System (INIS)

Stockli, Martin P.; Leitner, M.; Moehs, D.P.; Keller, R.; Welton, R.F.

2004-01-01

For over 20 years, Allison scanners have been used to measure emittances of low-energy ion beams. We show that scanning large trajectory angles produces ghost signals caused by the sampled beamlet impacting on an electric deflection plate. The ghost signal strength is proportional to the amount of beam entering the scanner. Depending on the ions, and their velocity, the ghost signals can have the opposite or the same polarity as the main beam signals. The ghost signals cause significant errors in the emittance estimates because they appear at large trajectory angles. These ghost signals often go undetected because they partly overlap with the real signals, are mostly below the 1% level, and often hide in the noise. A simple deflection plate modification is shown to reduce the ghost signal strength by over 99%

Ghost Signals In Allison Emittance Scanners

International Nuclear Information System (INIS)

Stockli, Martin P.; Leitner, M.; Keller, R.; Moehs, D.P.; Welton, R. F.

2005-01-01

For over 20 years, Allison scanners have been used to measure emittances of low-energy ion beams. We show that scanning large trajectory angles produces ghost signals caused by the sampled beamlet impacting on an electric deflection plate. The ghost signal strength is proportional to the amount of beam entering the scanner. Depending on the ions, and their velocity, the ghost signals can have the opposite or the same polarity as the main beam signals. The ghost signals cause significant errors in the emittance estimates because they appear at large trajectory angles. These ghost signals often go undetected because they partly overlap with the real signals, are mostly below the 1% level, and often hide in the noise. A simple deflection plate modification is shown to reduce the ghost signal strength by over 99%

Signal recovery of the corrupted metal impact signal using the adaptive filtering in NPPs

International Nuclear Information System (INIS)

Kim, Dai Il; Shin, Won Ky; Oh, Sung Hun; Yun, Won Young

1995-01-01

Loose Part Monitoring System (LPMS) is one of the fundamental diagnostic tools installed in the nuclear power plants. In this paper, recovery process algorithm and model for the corrupted impact signal generated by loose parts is presented. The characteristics of this algorithm can obtain a proper burst signal even though background noise is considerably high level comparing with actual impact signal. To verify performance of the proposed algorithm, we evaluate mathematically signal-to-noise ratio of primary output and noise. The performance of this recovery process algorithm is shown through computer simulation

Ultrahigh bandwidth signal processing

DEFF Research Database (Denmark)

Oxenløwe, Leif Katsuo

2016-01-01

Optical time lenses have proven to be very versatile for advanced optical signal processing. Based on a controlled interplay between dispersion and phase-modulation by e.g. four-wave mixing, the processing is phase-preserving, an hence useful for all types of data signals including coherent multi......-level modulation founats. This has enabled processing of phase-modulated spectrally efficient data signals, such as orthogonal frequency division multiplexed (OFDM) signa In that case, a spectral telescope system was used, using two time lenses with different focal lengths (chirp rates), yielding a spectral...... regeneratio These operations require a broad bandwidth nonlinear platform, and novel photonic integrated nonlinear platform like aluminum gallium arsenide nano-waveguides used for 1.28 Tbaud optical signal processing will be described....

Wireless data signal transmission system

DEFF Research Database (Denmark)

2014-01-01

The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver.......The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver....

Semi-classical signal analysis

KAUST Repository

Laleg-Kirati, Taous-Meriem

2012-09-30

This study introduces a new signal analysis method, based on a semi-classical approach. The main idea in this method is to interpret a pulse-shaped signal as a potential of a Schrödinger operator and then to use the discrete spectrum of this operator for the analysis of the signal. We present some numerical examples and the first results obtained with this method on the analysis of arterial blood pressure waveforms. © 2012 Springer-Verlag London Limited.

Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter.

Science.gov (United States)

Moshrefi-Ravasdjani, Behrouz; Hammel, Evelyn L; Kafitz, Karl W; Rose, Christine R

2017-09-01

In brain grey matter, excitatory synaptic transmission activates glutamate uptake into astrocytes, inducing sodium signals which propagate into neighboring astrocytes through gap junctions. These sodium signals have been suggested to serve an important role in neuro-metabolic coupling. So far, it is unknown if astrocytes in white matter-that is in brain regions devoid of synapses-are also able to undergo such intra- and intercellular sodium signalling. In the present study, we have addressed this question by performing quantitative sodium imaging in acute tissue slices of mouse corpus callosum. Focal application of glutamate induced sodium transients in SR101-positive astrocytes. These were largely unaltered in the presence of ionotropic glutamate receptors blockers, but strongly dampened upon pharmacological inhibition of glutamate uptake. Sodium signals induced in individual astrocytes readily spread into neighboring SR101-positive cells with peak amplitudes decaying monoexponentially with distance from the stimulated cell. In addition, spread of sodium was largely unaltered during pharmacological inhibition of purinergic and glutamate receptors, indicating gap junction-mediated, passive diffusion of sodium between astrocytes. Using cell-type-specific, transgenic reporter mice, we found that sodium signals also propagated, albeit less effectively, from astrocytes to neighboring oligodendrocytes and NG2 cells. Again, panglial spread was unaltered with purinergic and glutamate receptors blocked. Taken together, our results demonstrate that activation of sodium-dependent glutamate transporters induces sodium signals in white matter astrocytes, which spread within the astrocyte syncytium. In addition, we found a panglial passage of sodium signals from astrocytes to NG2 cells and oligodendrocytes, indicating functional coupling between these macroglial cells in white matter.

Signaling equilibria in sensorimotor interactions.

Science.gov (United States)

Leibfried, Felix; Grau-Moya, Jordi; Braun, Daniel A

2015-08-01

Although complex forms of communication like human language are often assumed to have evolved out of more simple forms of sensorimotor signaling, less attention has been devoted to investigate the latter. Here, we study communicative sensorimotor behavior of humans in a two-person joint motor task where each player controls one dimension of a planar motion. We designed this joint task as a game where one player (the sender) possesses private information about a hidden target the other player (the receiver) wants to know about, and where the sender's actions are costly signals that influence the receiver's control strategy. We developed a game-theoretic model within the framework of signaling games to investigate whether subjects' behavior could be adequately described by the corresponding equilibrium solutions. The model predicts both separating and pooling equilibria, in which signaling does and does not occur respectively. We observed both kinds of equilibria in subjects and found that, in line with model predictions, the propensity of signaling decreased with increasing signaling costs and decreasing uncertainty on the part of the receiver. Our study demonstrates that signaling games, which have previously been applied to economic decision-making and animal communication, provide a framework for human signaling behavior arising during sensorimotor interactions in continuous and dynamic environments. Copyright © 2015 Elsevier B.V. All rights reserved.

Redox signaling in plants.

Science.gov (United States)

Foyer, Christine H; Noctor, Graham

2013-06-01

Our aim is to deliver an authoritative and challenging perspective of current concepts in plant redox signaling, focusing particularly on the complex interface between the redox and hormone-signaling pathways that allow precise control of plant growth and defense in response to metabolic triggers and environmental constraints and cues. Plants produce significant amounts of singlet oxygen and other reactive oxygen species (ROS) as a result of photosynthetic electron transport and metabolism. Such pathways contribute to the compartment-specific redox-regulated signaling systems in plant cells that convey information to the nucleus to regulate gene expression. Like the chloroplasts and mitochondria, the apoplast-cell wall compartment makes a significant contribution to the redox signaling network, but unlike these organelles, the apoplast has a low antioxidant-buffering capacity. The respective roles of ROS, low-molecular antioxidants, redox-active proteins, and antioxidant enzymes are considered in relation to the functions of plant hormones such as salicylic acid, jasmonic acid, and auxin, in the composite control of plant growth and defense. Regulation of redox gradients between key compartments in plant cells such as those across the plasma membrane facilitates flexible and multiple faceted opportunities for redox signaling that spans the intracellular and extracellular environments. In conclusion, plants are recognized as masters of the art of redox regulation that use oxidants and antioxidants as flexible integrators of signals from metabolism and the environment.

Signals and Systems in Biomedical Engineering Signal Processing and Physiological Systems Modeling

CERN Document Server

Devasahayam, Suresh R

2013-01-01

The use of digital signal processing is ubiquitous in the field of physiology and biomedical engineering. The application of such mathematical and computational tools requires a formal or explicit understanding of physiology. Formal models and analytical techniques are interlinked in physiology as in any other field. This book takes a unitary approach to physiological systems, beginning with signal measurement and acquisition, followed by signal processing, linear systems modelling, and computer simulations. The signal processing techniques range across filtering, spectral analysis and wavelet analysis. Emphasis is placed on fundamental understanding of the concepts as well as solving numerical problems. Graphs and analogies are used extensively to supplement the mathematics. Detailed models of nerve and muscle at the cellular and systemic levels provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real wor...

Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.

Science.gov (United States)

Mak, Kingston Kinglun; Chen, Miao-Hsueh; Day, Timothy F; Chuang, Pao-Tien; Yang, Yingzi

2006-09-01

Both the Wnt/beta-catenin and Ihh signaling pathways play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation, chondrocyte proliferation and hypertrophy. To understand the genetic interaction between these two signaling pathways, we have inactivated the beta-catenin gene and upregulated Ihh signaling simultaneously in the same cells during endochondral skeletal development using beta-catenin and patched 1 floxed alleles. We uncovered previously unexpected roles of Ihh signaling in synovial joint formation and the essential function of Wnt/beta-catenin signaling in regulating chondrocyte survival. More importantly, we found that Wnt and Ihh signaling interact with each other in distinct ways to control osteoblast differentiation, chondrocyte proliferation, hypertrophy, survival and synovial joint formation in the developing endochondral bone. Beta-catenin is required downstream of Ihh signaling and osterix expression for osteoblast differentiation. But in chondrocyte survival, beta-catenin is required upstream of Ihh signaling to inhibit chondrocyte apoptosis. In addition, Ihh signaling can inhibit chondrocyte hypertrophy and synovial joint formation independently of beta-catenin. However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation.

Zufällige Signale

Science.gov (United States)

Plaßmann, Wilfried

Die hier betrachteten Signale werden auch als stochastische Signale bezeichnet. Sie sind zufällig, d. h. ihr Augenblickswert ist nicht vorhersagbar. Abb. 118.1 zeigt eine Unterteilung nach den Signaleigenschaften. Über die nichtstationären Signale lässt sich keinerlei Aussage machen, und sie werden hier deshalb auch nicht weiter betrachtet. Für die stationären Signale gilt, dass ihr Momentanwert zwar auch nicht vorhergesagt werden kann, dass sie aber trotzdem gewisse auswertbare Eigenschaften besitzen, die allerdings statistischer Art sind und deshalb nur mit den Gesetzen der Wahrscheinlichkeitstheorie erfasst werden können. Zwar sind - theoretisch - für die Anwendung der Wahrscheinlichkeitstheorie unendlich viele Probenwerte zu nehmen, in der Praxis hat sich aber gezeigt, dass man auch mit einer endlichen Anzahl dem gesuchten Wert schon ausreichend nahe kommen kann.

Signalling crosstalk in plants: emerging issues.

Science.gov (United States)

Taylor, Jane E; McAinsh, Martin R

2004-01-01

The Oxford English Dictionary defines crosstalk as 'unwanted transfer of signals between communication channels'. How does this definition relate to the way in which we view the organization and function of signalling pathways? Recent advances in the field of plant signalling have challenged the traditional view of a signalling transduction cascade as isolated linear pathways. Instead the picture emerging of the mechanisms by which plants transduce environmental signals is of the interaction between transduction chains. The manner in which these interactions occur (and indeed whether the transfer of these signals is 'unwanted' or beneficial) is currently the topic of intense research.

Thermal resonance in signal transmission

International Nuclear Information System (INIS)

Reigada, Ramon; Sarmiento, Antonio; Lindenberg, Katja

2001-01-01

We use temperature tuning to control signal propagation in simple one-dimensional arrays of masses connected by hard anharmonic springs and with no local potentials. In our numerical model a sustained signal is applied at one site of a chain immersed in a thermal environment and the signal-to-noise ratio is measured at each oscillator. We show that raising the temperature can lead to enhanced signal propagation along the chain, resulting in thermal resonance effects akin to the resonance observed in arrays of bistable systems

Thermal resonance in signal transmission

Energy Technology Data Exchange (ETDEWEB)

Reigada, Ramon; Sarmiento, Antonio; Lindenberg, Katja

2001-06-01

We use temperature tuning to control signal propagation in simple one-dimensional arrays of masses connected by hard anharmonic springs and with no local potentials. In our numerical model a sustained signal is applied at one site of a chain immersed in a thermal environment and the signal-to-noise ratio is measured at each oscillator. We show that raising the temperature can lead to enhanced signal propagation along the chain, resulting in thermal resonance effects akin to the resonance observed in arrays of bistable systems.

Aberrant Signaling Pathways in Glioma

International Nuclear Information System (INIS)

Nakada, Mitsutoshi; Kita, Daisuke; Watanabe, Takuya; Hayashi, Yutaka; Teng, Lei; Pyko, Ilya V.; Hamada, Jun-Ichiro

2011-01-01

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies

Predicting Secretory Proteins with SignalP

DEFF Research Database (Denmark)

Nielsen, Henrik

2017-01-01

SignalP is the currently most widely used program for prediction of signal peptides from amino acid sequences. Proteins with signal peptides are targeted to the secretory pathway, but are not necessarily secreted. After a brief introduction to the biology of signal peptides and the history...

Research methods for graduate students: a practical framework to guide teachers and learners.

Science.gov (United States)

Pearce, Patricia F; Christian, Becky J; Smith, Sandra L; Vance, David E

2014-01-01

The purpose of this article is to present the Arrow Framework for Research Design, an organizing framework that facilitates teaching and learning of research methods, providing logical organization of interrelationships between concepts, content, and context of research methods, and practice application. The Arrow Framework was designed for teaching and learning research methods to facilitate progression of knowledge acquisition through synthesis. The framework was developed over several years and used successfully to teach masters, DNP, and PhD nursing students across five universities. The framework is presented with incremental graphics and narrative for teaching. The Arrow Framework provides user-friendly information, in an organized and systematic approach demonstrated as successful for teaching and learning the foundational language of research, facilitating synthesis and application in scholarly endeavors. The Arrow Framework will be useful for educators and students in teaching and learning research language, relationships, and application of methods. The materials are easily adaptable to slide or paper presentation, and meet learner needs for narrative and visual presentation. Teaching research design to graduate students is critical to meet the expectation that students are to understand the scientific underpinnings of nursing science and appropriate use of evidence that are essential for well-educated practitioners. ©2013 The Author(s) ©2013 American Association of Nurse Practitioners.

Signals and systems laboratory with Matlab

CERN Document Server

Palamides, Alex

2010-01-01

Introduction to MATLAB®Working EnvironmentGetting StartedMemory ManagementVectorsMatricesPlotting with MATLABComplex NumbersM-FilesInput-Output CommandsFile ManagementLogical-Relational OperatorsControl FlowSymbolic VariablesPolynomials(Pseudo)Random NumbersSignalsCategorization by the Variable TypeBasic Continuous-Time SignalsDiscrete-Time SignalsProperties of SignalsTransformations of the Time Variable for Continuous-Time SignalsTransformations of the Time Variable for Discrete-Time SignalsSystemsSystems ClassificationProperties of SystemsTime Domain System AnalysisImpulse ResponseContinuous Time Convolution Convolution PropertiesInterconnections of SystemsStabilityDiscrete-Time ConvolutionSystems Described by Difference EquationsFiltersStability Criterion for Discrete-Time SystemsSystems Described by Differential EquationsStep Response of a SystemFourier SeriesOrthogonality of Complex Exponential SignalsComplex Exponential Fourier SeriesTrigonometric Fourier SeriesFourier Series in the Cosine with Phase F...

Guard Cell Signal Transduction Network: Advances in Understanding Abscisic Acid, CO2, and Ca2+ Signaling

KAUST Repository

Kim, Tae-Houn

2010-05-04

Stomatal pores are formed by pairs of specialized epidermal guard cells and serve as major gateways for both CO2 influx into plants from the atmosphere and transpirational water loss of plants. Because they regulate stomatal pore apertures via integration of both endogenous hormonal stimuli and environmental signals, guard cells have been highly developed as a model system to dissect the dynamics and mechanisms of plant-cell signaling. The stress hormone ABA and elevated levels of CO2 activate complex signaling pathways in guard cells that are mediated by kinases/phosphatases, secondary messengers, and ion channel regulation. Recent research in guard cells has led to a new hypothesis for how plants achieve specificity in intracellular calcium signaling: CO2 and ABA enhance (prime) the calcium sensitivity of downstream calcium-signaling mechanisms. Recent progress in identification of early stomatal signaling components are reviewed here, including ABA receptors and CO2-binding response proteins, as well as systems approaches that advance our understanding of guard cell-signaling mechanisms.

Guard Cell Signal Transduction Network: Advances in Understanding Abscisic Acid, CO2, and Ca2+ Signaling

KAUST Repository

Kim, Tae-Houn; Bö hmer, Maik; Hu, Honghong; Nishimura, Noriyuki; Schroeder, Julian I.

2010-01-01

Stomatal pores are formed by pairs of specialized epidermal guard cells and serve as major gateways for both CO2 influx into plants from the atmosphere and transpirational water loss of plants. Because they regulate stomatal pore apertures via integration of both endogenous hormonal stimuli and environmental signals, guard cells have been highly developed as a model system to dissect the dynamics and mechanisms of plant-cell signaling. The stress hormone ABA and elevated levels of CO2 activate complex signaling pathways in guard cells that are mediated by kinases/phosphatases, secondary messengers, and ion channel regulation. Recent research in guard cells has led to a new hypothesis for how plants achieve specificity in intracellular calcium signaling: CO2 and ABA enhance (prime) the calcium sensitivity of downstream calcium-signaling mechanisms. Recent progress in identification of early stomatal signaling components are reviewed here, including ABA receptors and CO2-binding response proteins, as well as systems approaches that advance our understanding of guard cell-signaling mechanisms.

Laboratory observation of hot bands of H+3

International Nuclear Information System (INIS)

Bawendi, M.G.; Rehfuss, B.D.; Oka, T.

1990-01-01

The (2ν 2 ,l=2 left-arrow ν 2 ), (2ν 2 ,l=0 left-arrow ν 2 ), and (ν 1 +ν 2 left-arrow ν 1 ) hot bands of H + 3 were observed. The vibrationally hot ions were produced in a liquid nitrogen cooled 6 kHz ac discharge using gas mixtures of H 2 and He. The spectra were detected in direct absorption using a newly extended tunable difference frequency spectrometer using both LiNbO 3 and LiIO 3 crystals as nonlinear optical elements. The range of this spectrometer is now ∼5300--∼1900 cm -1 . The positions of the rovibrational transitions compare extremely well with the theoretical predictions of Miller and Tennyson. A vibrational temperature study of the discharge indicates a significant population inversion between the ν 1 and ν 2 levels

Testing the causality of Hawkes processes with time reversal

Science.gov (United States)

Cordi, Marcus; Challet, Damien; Muni Toke, Ioane

2018-03-01

We show that univariate and symmetric multivariate Hawkes processes are only weakly causal: the true log-likelihoods of real and reversed event time vectors are almost equal, thus parameter estimation via maximum likelihood only weakly depends on the direction of the arrow of time. In ideal (synthetic) conditions, tests of goodness of parametric fit unambiguously reject backward event times, which implies that inferring kernels from time-symmetric quantities, such as the autocovariance of the event rate, only rarely produce statistically significant fits. Finally, we find that fitting financial data with many-parameter kernels may yield significant fits for both arrows of time for the same event time vector, sometimes favouring the backward time direction. This goes to show that a significant fit of Hawkes processes to real data with flexible kernels does not imply a definite arrow of time unless one tests it.

Generation and coherent detection of QPSK signal using a novel method of digital signal processing

Science.gov (United States)

Zhao, Yuan; Hu, Bingliang; He, Zhen-An; Xie, Wenjia; Gao, Xiaohui

2018-02-01

We demonstrate an optical quadrature phase-shift keying (QPSK) signal transmitter and an optical receiver for demodulating optical QPSK signal with homodyne detection and digital signal processing (DSP). DSP on the homodyne detection scheme is employed without locking the phase of the local oscillator (LO). In this paper, we present an extracting one-dimensional array of down-sampling method for reducing unwanted samples of constellation diagram measurement. Such a novel scheme embodies the following major advantages over the other conventional optical QPSK signal detection methods. First, this homodyne detection scheme does not need strict requirement on LO in comparison with linear optical sampling, such as having a flat spectral density and phase over the spectral support of the source under test. Second, the LabVIEW software is directly used for recovering the QPSK signal constellation without employing complex DSP circuit. Third, this scheme is applicable to multilevel modulation formats such as M-ary PSK and quadrature amplitude modulation (QAM) or higher speed signals by making minor changes.

On-line signal trend identification

International Nuclear Information System (INIS)

Tambouratzis, T.; Antonopoulos-Domis, M.

2004-01-01

An artificial neural network, based on the self-organizing map, is proposed for on-line signal trend identification. Trends are categorized at each incoming signal as steady-state, increasing and decreasing, while they are further classified according to characteristics such signal shape and rate of change. Tests with model-generated signals illustrate the ability of the self-organizing map to accurately and reliably perform on-line trend identification in terms of both detection and classification. The proposed methodology has been found robust to the presence of white noise

Signal generation in gas detectors

International Nuclear Information System (INIS)

Stillman, A.

1993-01-01

This tutorial describes the generation of electrical signals in gas detectors. Ionization of the gas by the passage of charged particles generates these signals. Starting with the Bethe-Bloch equation, the treatment is a general introduction to the production of ion-pairs in gas devices. I continue with the characterization of the ionization as an electrical signal, and calculate the signal current in a simple example. Another example demonstrates the effect of space charge on the design of a detector. The AGS Booster ionization profile monitor is a model for this calculation

Foundations of signal processing

CERN Document Server

Vetterli, Martin; Goyal, Vivek K

2014-01-01

This comprehensive and engaging textbook introduces the basic principles and techniques of signal processing, from the fundamental ideas of signals and systems theory to real-world applications. Students are introduced to the powerful foundations of modern signal processing, including the basic geometry of Hilbert space, the mathematics of Fourier transforms, and essentials of sampling, interpolation, approximation and compression. The authors discuss real-world issues and hurdles to using these tools, and ways of adapting them to overcome problems of finiteness and localisation, the limitations of uncertainty and computational costs. Standard engineering notation is used throughout, making mathematical examples easy for students to follow, understand and apply. It includes over 150 homework problems and over 180 worked examples, specifically designed to test and expand students' understanding of the fundamentals of signal processing, and is accompanied by extensive online materials designed to aid learning, ...

Signal-to-Signal Ratio Independent Speaker Identification for Co-channel Speech Signals

DEFF Research Database (Denmark)

Saeidi, Rahim; Mowlaee, Pejman; Kinnunen, Tomi

2010-01-01

In this paper, we consider speaker identification for the co-channel scenario in which speech mixture from speakers is recorded by one microphone only. The goal is to identify both of the speakers from their mixed signal. High recognition accuracies have already been reported when an accurately...

Properties of light induced EPR signals in enamel and their possible interference with gamma-induced signals

International Nuclear Information System (INIS)

Sholom, S.V.; Chumak, V.V.; Haskell, E.H.; Hayes, R.B.; Kenner, G.H.

1998-01-01

Exposure of tooth enamel to natural and artificial UV light results in stable EPR signals with g-factors of 1.9985, 2.0018, 2.0045, 2.0052 and 2.0110. The first three signals correspond to the parallel and perpendicular components of the radiation induced or dosimetric signal and the native signal reported in dosimetry and dating studies. The latter two signals were found to be sensitive to both gamma-ray and sunlight exposure, however, their responses to light differed from that to radiation, giving rise to the possibility of using them as indicators of the dose-equivalent resulting from light exposure

Smart, Injury-Triggered Therapy for Ocular Trauma

Science.gov (United States)

2016-10-01

eye. There is a significant autofluorescence in the outer segments of the retina , present in the absence of the primary MMP2 antibody (yellow arrows... autofluorescence in the outer segments of the retina , present in the absence of the primary MMP2 antibody (yellow arrows). Healthy photoreceptor...negative for MMP9 in the control eye. There is a significant autofluorescence in the outer segments of the retina , present in the absence of the primary

Polarographic study of the Cu(II)/Cu(I) system in the presence of 1-ascorbic acid and 0,1 M ClK; Estudio polarografico del sistema Cu(II)/Cu(I) en presencia del acido 1-ascorbico y en ClK 0,1 M

Energy Technology Data Exchange (ETDEWEB)

Alonso Lopez, J

1969-07-01

While studying the catalytic effect of Cu{sup {down_arrow}}2 ions on the oxidation process of 1-ascorbic acid, it has been observed that, in a 0,1 M solution of K1 at a pH 6 to 7, the above acid gives rise in the presence of Cu{sup {down_arrow}}2 ions to a polarographic wave of half-wave potential of -0,41 V (vs. S.C.E.). (Author) 14 refs.

Optimal Spacecraft Attitude Control Using Aerodynamic Torques

Science.gov (United States)

2007-03-01

His design resembles a badminton shuttlecock and “uses passive aerodynamic drag torques to stabilize pitch and yaw” and active magnetic torque...Ravindran’s and Hughes’ ‘arrow-like’ design. Psiaki notes that “this arrow concept has been modified to become a badminton shuttlecock-type design...panels were placed to the rear of the center-of-mass, similar to a badminton shuttlecock, to provide passive stability about the pitch and yaw axes

Canonical Wnt signaling in diabetic retinopathy.

Science.gov (United States)

Chen, Qian; Ma, Jian-Xing

2017-10-01

Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis. Wnt signaling regulates expression of multiple genes that control retinal development and eye organogenesis, and dysregulated Wnt signaling plays pathophysiological roles in many ocular diseases, including DR. This review highlights recent progress in studies of Wnt signaling in DR. We discuss Wnt signaling regulation in the retina and dysregulation of Wnt signaling associated with ocular diseases with an emphasis on DR. We also discuss the therapeutic potential of modulating Wnt signaling in DR. Continued studies in this field will advance our current understanding on DR and contribute to the development of new treatments. Copyright © 2017 Elsevier Ltd. All rights reserved.

Metabolites in vertebrate Hedgehog signaling.

Science.gov (United States)

Roberg-Larsen, Hanne; Strand, Martin Frank; Krauss, Stefan; Wilson, Steven Ray

2014-04-11

The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling is associated with a number of disease conditions including congenital disorders and cancer. In particular, deregulation of HH signaling has been linked to skin, brain, lung, colon and pancreatic cancers. Key mediators of the HH signaling pathway are the 12-pass membrane protein Patched (PTC), the 7-pass membrane protein Smoothened (SMO) and the GLI transcription factors. PTC shares homology with the RND family of small-molecule transporters and it has been proposed that it interferes with SMO through metabolites. Although a conclusive picture is lacking, substantial efforts are made to identify and understand natural metabolites/sterols, including cholesterol, vitamin D3, oxysterols and glucocorticoides, that may be affected by, or influence the HH signaling cascade at the level of PTC and SMO. In this review we will elaborate the role of metabolites in HH signaling with a focus on oxysterols, and discuss advancements in modern analytical approaches in the field. Copyright © 2014 Elsevier Inc. All rights reserved.

Insulin Signaling and Heart Failure

Science.gov (United States)

Riehle, Christian; Abel, E. Dale

2016-01-01

Heart failure is associated with generalized insulin resistance. Moreover, insulin resistant states such as type 2 diabetes and obesity increases the risk of heart failure even after adjusting for traditional risk factors. Insulin resistance or type 2 diabetes alters the systemic and neurohumoral milieu leading to changes in metabolism and signaling pathways in the heart that may contribute to myocardial dysfunction. In addition, changes in insulin signaling within cardiomyocytes develop in the failing heart. The changes range from activation of proximal insulin signaling pathways that may contribute to adverse left ventricular remodeling and mitochondrial dysfunction to repression of distal elements of insulin signaling pathways such as forkhead (FOXO) transcriptional signaling or glucose transport which may also impair cardiac metabolism, structure and function. This article will review the complexities of insulin signaling within the myocardium and ways in which these pathways are altered in heart failure or in conditions associated with generalized insulin resistance. The implications of these changes for therapeutic approaches to treating or preventing heart failure will be discussed. PMID:27034277

Neurotransmitter signaling in white matter.

Science.gov (United States)

Butt, Arthur M; Fern, Robert F; Matute, Carlos

2014-11-01

White matter (WM) tracts are bundles of myelinated axons that provide for rapid communication throughout the CNS and integration in grey matter (GM). The main cells in myelinated tracts are oligodendrocytes and astrocytes, with small populations of microglia and oligodendrocyte precursor cells. The prominence of neurotransmitter signaling in WM, which largely exclude neuronal cell bodies, indicates it must have physiological functions other than neuron-to-neuron communication. A surprising aspect is the diversity of neurotransmitter signaling in WM, with evidence for glutamatergic, purinergic (ATP and adenosine), GABAergic, glycinergic, adrenergic, cholinergic, dopaminergic and serotonergic signaling, acting via a wide range of ionotropic and metabotropic receptors. Both axons and glia are potential sources of neurotransmitters and may express the respective receptors. The physiological functions of neurotransmitter signaling in WM are subject to debate, but glutamate and ATP-mediated signaling have been shown to evoke Ca(2+) signals in glia and modulate axonal conduction. Experimental findings support a model of neurotransmitters being released from axons during action potential propagation acting on glial receptors to regulate the homeostatic functions of astrocytes and myelination by oligodendrocytes. Astrocytes also release neurotransmitters, which act on axonal receptors to strengthen action potential propagation, maintaining signaling along potentially long axon tracts. The co-existence of multiple neurotransmitters in WM tracts suggests they may have diverse functions that are important for information processing. Furthermore, the neurotransmitter signaling phenomena described in WM most likely apply to myelinated axons of the cerebral cortex and GM areas, where they are doubtless important for higher cognitive function. © 2014 Wiley Periodicals, Inc.

Intracellular signal modulation by nanomaterials.

Science.gov (United States)

Hussain, Salik; Garantziotis, Stavros; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Baeza-Squiban, Armelle; Boland, Sonja

2014-01-01

A thorough understanding of the interactions of nanomaterials with biological systems and the resulting activation of signal transduction pathways is essential for the development of safe and consumer friendly nanotechnology. Here we present an overview of signaling pathways induced by nanomaterial exposures and describe the possible correlation of their physicochemical characteristics with biological outcomes. In addition to the hierarchical oxidative stress model and a review of the intrinsic and cell-mediated mechanisms of reactive oxygen species (ROS) generating capacities of nanomaterials, we also discuss other oxidative stress dependent and independent cellular signaling pathways. Induction of the inflammasome, calcium signaling, and endoplasmic reticulum stress are reviewed. Furthermore, the uptake mechanisms can be of crucial importance for the cytotoxicity of nanomaterials and membrane-dependent signaling pathways have also been shown to be responsible for cellular effects of nanomaterials. Epigenetic regulation by nanomaterials, effects of nanoparticle-protein interactions on cell signaling pathways, and the induction of various cell death modalities by nanomaterials are described. We describe the common trigger mechanisms shared by various nanomaterials to induce cell death pathways and describe the interplay of different modalities in orchestrating the final outcome after nanomaterial exposures. A better understanding of signal modulations induced by nanomaterials is not only essential for the synthesis and design of safer nanomaterials but will also help to discover potential nanomedical applications of these materials. Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future.

Signal Processing and Neural Network Simulator

Science.gov (United States)

Tebbe, Dennis L.; Billhartz, Thomas J.; Doner, John R.; Kraft, Timothy T.

1995-04-01

The signal processing and neural network simulator (SPANNS) is a digital signal processing simulator with the capability to invoke neural networks into signal processing chains. This is a generic tool which will greatly facilitate the design and simulation of systems with embedded neural networks. The SPANNS is based on the Signal Processing WorkSystemTM (SPWTM), a commercial-off-the-shelf signal processing simulator. SPW provides a block diagram approach to constructing signal processing simulations. Neural network paradigms implemented in the SPANNS include Backpropagation, Kohonen Feature Map, Outstar, Fully Recurrent, Adaptive Resonance Theory 1, 2, & 3, and Brain State in a Box. The SPANNS was developed by integrating SAIC's Industrial Strength Neural Networks (ISNN) Software into SPW.

Blind I/Q Signal Separation-Based Solutions for Receiver Signal Processing

Directory of Open Access Journals (Sweden)

Visa Koivunen

2005-09-01

Full Text Available This paper introduces some novel digital signal processing (DSP-based approaches to some of the most fundamental tasks of radio receivers, namely, channel equalization, carrier synchronization, and I/Q mismatch compensation. The leading principle is to show that all these problems can be solved blindly (i.e., without training signals by forcing the I and Q components of the observed data as independent as possible. Blind signal separation (BSS is then introduced as an efficient tool to carry out these tasks, and simulation examples are used to illustrate the performance of the proposed approaches. The main application area of the presented carrier synchronization and I/Q mismatch compensation techniques is in direct-conversion type receivers, while the proposed channel equalization principles basically apply to any radio architecture.

Multiresolution signal decomposition schemes

NARCIS (Netherlands)

J. Goutsias (John); H.J.A.M. Heijmans (Henk)

1998-01-01

textabstract[PNA-R9810] Interest in multiresolution techniques for signal processing and analysis is increasing steadily. An important instance of such a technique is the so-called pyramid decomposition scheme. This report proposes a general axiomatic pyramid decomposition scheme for signal analysis

Semi-classical signal analysis

KAUST Repository

Laleg-Kirati, Taous-Meriem; Cré peau, Emmanuelle; Sorine, Michel

2012-01-01

This study introduces a new signal analysis method, based on a semi-classical approach. The main idea in this method is to interpret a pulse-shaped signal as a potential of a Schrödinger operator and then to use the discrete spectrum

Optimal fault signal estimation

NARCIS (Netherlands)

Stoorvogel, Antonie Arij; Niemann, H.H.; Saberi, A.; Sannuti, P.

2002-01-01

We consider here both fault identification and fault signal estimation. Regarding fault identification, we seek either exact or almost fault identification. On the other hand, regarding fault signal estimation, we seek either $H_2$ optimal, $H_2$ suboptimal or Hinfinity suboptimal estimation. By

Signal processing for radiation detectors

CERN Document Server

Nakhostin, Mohammad

2018-01-01

This book provides a clear understanding of the principles of signal processing of radiation detectors. It puts great emphasis on the characteristics of pulses from various types of detectors and offers a full overview on the basic concepts required to understand detector signal processing systems and pulse processing techniques. Signal Processing for Radiation Detectors covers all of the important aspects of signal processing, including energy spectroscopy, timing measurements, position-sensing, pulse-shape discrimination, and radiation intensity measurement. The book encompasses a wide range of applications so that readers from different disciplines can benefit from all of the information. In addition, this resource: * Describes both analog and digital techniques of signal processing * Presents a complete compilation of digital pulse processing algorithms * Extrapolates content from more than 700 references covering classic papers as well as those of today * Demonstrates concepts with more than 340 origin...

High-level expression of nattokinase in Bacillus licheniformis by manipulating signal peptide and signal peptidase.

Science.gov (United States)

Cai, D; Wei, X; Qiu, Y; Chen, Y; Chen, J; Wen, Z; Chen, S

2016-09-01

Nattokinase is an enzyme produced by Bacillus licheniformis and has potential to be used as a drug for treating cardiovascular disease due to its beneficial effects of preventing fibrin clots etc. However, the low activity and titre of this protein produced by B. licheniformis often hinders its application of commercial production. The aim of this work is to improve the nattokinase production by manipulating signal peptides and signal peptidases in B. licheniformis. The P43 promoter, amyL terminator and AprN target gene were used to form the nattokinase expression vector, pHY-SP-NK, which was transformed into B. licheniformis and nattokinase was expressed successfully. A library containing 81 predicted signal peptides was constructed for nattokinase expression in B. licheniformis, with the maximum activity being obtained under the signal peptide of AprE. Among four type I signal peptidases genes (sipS, sipT, sipV, sipW) in B. licheniformis, the deletion of sipV resulted in a highest decrease in nattokinase activity. Overexpression of sipV in B. licheniformis led to a nattokinase activity of 35·60 FU ml(-1) , a 4·68-fold improvement over activity produced by the initial strain. This work demonstrates the potential of B. licheniformis for industrial production of nattokinase through manipulation of signal peptides and signal peptidases expression. This study has screened the signal peptides of extracellular proteins of B. licheniformis for nattokinase production. Four kinds of Type I signal peptidases genes have been detected respectively in B. licheniformis to identify which one played the vital role for nattokinase production. This study provided a promising strain for industry production of nattokinase. © 2016 The Society for Applied Microbiology.

Calcium signalling silencing in atrial fibrillation.

Science.gov (United States)

Greiser, Maura

2017-06-15

Subcellular calcium signalling silencing is a novel and distinct cellular and molecular adaptive response to rapid cardiac activation. Calcium signalling silencing develops during short-term sustained rapid atrial activation as seen clinically during paroxysmal atrial fibrillation (AF). It is the first 'anti-arrhythmic' adaptive response in the setting of AF and appears to counteract the maladaptive changes that lead to intracellular Ca 2+ signalling instability and Ca 2+ -based arrhythmogenicity. Calcium signalling silencing results in a failed propagation of the [Ca 2+ ] i signal to the myocyte centre both in patients with AF and in a rabbit model. This adaptive mechanism leads to a substantial reduction in the expression levels of calcium release channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum, and the frequency of Ca 2+ sparks and arrhythmogenic Ca 2+ waves remains low. Less Ca 2+ release per [Ca 2+ ] i transient, increased fast Ca 2+ buffering strength, shortened action potentials and reduced L-type Ca 2+ current contribute to a substantial reduction of intracellular [Na + ]. These features of Ca 2+ signalling silencing are distinct and in contrast to the changes attributed to Ca 2+ -based arrhythmogenicity. Some features of Ca 2+ signalling silencing prevail in human AF suggesting that the Ca 2+ signalling 'phenotype' in AF is a sum of Ca 2+ stabilizing (Ca 2+ signalling silencing) and Ca 2+ destabilizing (arrhythmogenic unstable Ca 2+ signalling) factors. Calcium signalling silencing is a part of the mechanisms that contribute to the natural progression of AF and may limit the role of Ca 2+ -based arrhythmogenicity after the onset of AF. © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

Signal trend identification with fuzzy methods

International Nuclear Information System (INIS)

Reifman, J.; Tsoukalas, L. H.; Wang, X.; Wei, T. Y. C.

1999-01-01

A fuzzy-logic-based methodology for on-line signal trend identification is introduced. Although signal trend identification is complicated by the presence of noise, fuzzy logic can help capture important features of on-line signals and classify incoming power plant signals into increasing, decreasing and steady-state trend categories. In order to verify the methodology, a code named PROTREN is developed and tested using plant data. The results indicate that the code is capable of detecting transients accurately, identifying trends reliably, and not misinterpreting a steady-state signal as a transient one

PKD signaling and pancreatitis

Science.gov (United States)

Yuan, Jingzhen; Pandol, Stephen J.

2016-01-01

Background Acute pancreatitis is a serious medical disorder with no current therapies directed to the molecular pathogenesis of the disorder. Inflammation, inappropriate intracellular activation of digestive enzymes, and parenchymal acinar cell death by necrosis are the critical pathophysiologic processes of acute pancreatitis. Thus, it is necessary to elucidate the key molecular signals that mediate these pathobiologic processes and develop new therapeutic strategies to attenuate the appropriate signaling pathways in order to improve outcomes for this disease. A novel serine/threonine protein kinase D (PKD) family has emerged as key participants in signal transduction, and this family is increasingly being implicated in the regulation of multiple cellular functions and diseases. Methods This review summarizes recent findings of our group and others regarding the signaling pathway and the biological roles of the PKD family in pancreatic acinar cells. In particular, we highlight our studies of the functions of PKD in several key pathobiologic processes associated with acute pancreatitis in experimental models. Results Our findings reveal that PKD signaling is required for NF-κB activation/inflammation, intracellular zymogen activation, and acinar cell necrosis in rodent experimental pancreatitis. Novel small-molecule PKD inhibitors attenuate the severity of pancreatitis in both in vitro and in vivo experimental models. Further, this review emphasizes our latest advances in the therapeutic application of PKD inhibitors to experimental pancreatitis after the initiation of pancreatitis. Conclusions These novel findings suggest that PKD signaling is a necessary modulator in key initiating pathobiologic processes of pancreatitis, and that it constitutes a novel therapeutic target for treatments of this disorder. PMID:26879861

47 CFR 69.125 - Dedicated signalling transport.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Dedicated signalling transport. 69.125 Section... (CONTINUED) ACCESS CHARGES Computation of Charges § 69.125 Dedicated signalling transport. (a) Dedicated signalling transport shall consist of two elements, a signalling link charge and a signalling transfer point...

Ubiquitination in apoptosis signaling

NARCIS (Netherlands)

van de Kooij, L.W.

2014-01-01

The work described in this thesis focuses on ubiquitination and protein degradation, with an emphasis on how these processes regulate apoptosis signaling. More specifically, our aims were: 1. To increase the understanding of ubiquitin-mediated regulation of apoptosis signaling. 2. To identify the E3

Design principles of nuclear receptor signaling: how complex networking improves signal transduction

Science.gov (United States)

Kolodkin, Alexey N; Bruggeman, Frank J; Plant, Nick; Moné, Martijn J; Bakker, Barbara M; Campbell, Moray J; van Leeuwen, Johannes P T M; Carlberg, Carsten; Snoep, Jacky L; Westerhoff, Hans V

2010-01-01

The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of ‘design' aspects of the topology of these networks that might appear unnecessarily complex or even functionally paradoxical. In realistic kinetic models of increasing complexity, calculations show how these features correspond to potentially important design principles, e.g.: (i) cytosolic ‘nuclear' receptor may shuttle signal molecules to the nucleus, (ii) the active export of NRs may ensure that there is sufficient receptor protein to capture ligand at the cytoplasmic membrane, (iii) a three conveyor belts design dissipating GTP-free energy, greatly aids response, (iv) the active export of importins may prevent sequestration of NRs by importins in the nucleus and (v) the unspecific nature of the nuclear pore may ensure signal-flux robustness. In addition, the models developed are suitable for implementation in specific cases of NR-mediated signaling, to predict individual receptor functions and differential sensitivity toward physiological and pharmacological ligands. PMID:21179018

Ultrasonic correlator versus signal averager as a signal to noise enhancement instrument

Science.gov (United States)

Kishoni, Doron; Pietsch, Benjamin E.

1989-01-01

Ultrasonic inspection of thick and attenuating materials is hampered by the reduced amplitudes of the propagated waves to a degree that the noise is too high to enable meaningful interpretation of the data. In order to overcome the low Signal to Noise (S/N) ratio, a correlation technique has been developed. In this method, a continuous pseudo-random pattern generated digitally is transmitted and detected by piezoelectric transducers. A correlation is performed in the instrument between the received signal and a variable delayed image of the transmitted one. The result is shown to be proportional to the impulse response of the investigated material, analogous to a signal received from a pulsed system, with an improved S/N ratio. The degree of S/N enhancement depends on the sweep rate. This paper describes the correlator, and compares it to the method of enhancing S/N ratio by averaging the signals. The similarities and differences between the two are highlighted and the potential advantage of the correlator system is explained.

Novel ultra-wideband photonic signal generation and transmission featuring digital signal processing bit error rate measurements

DEFF Research Database (Denmark)

Gibbon, Timothy Braidwood; Yu, Xianbin; Tafur Monroy, Idelfonso

2009-01-01

We propose the novel generation of photonic ultra-wideband signals using an uncooled DFB laser. For the first time we experimentally demonstrate bit-for-bit DSP BER measurements for transmission of a 781.25 Mbit/s photonic UWB signal.......We propose the novel generation of photonic ultra-wideband signals using an uncooled DFB laser. For the first time we experimentally demonstrate bit-for-bit DSP BER measurements for transmission of a 781.25 Mbit/s photonic UWB signal....

A novel signal compression method based on optimal ensemble empirical mode decomposition for bearing vibration signals

Science.gov (United States)

Guo, Wei; Tse, Peter W.

2013-01-01

Today, remote machine condition monitoring is popular due to the continuous advancement in wireless communication. Bearing is the most frequently and easily failed component in many rotating machines. To accurately identify the type of bearing fault, large amounts of vibration data need to be collected. However, the volume of transmitted data cannot be too high because the bandwidth of wireless communication is limited. To solve this problem, the data are usually compressed before transmitting to a remote maintenance center. This paper proposes a novel signal compression method that can substantially reduce the amount of data that need to be transmitted without sacrificing the accuracy of fault identification. The proposed signal compression method is based on ensemble empirical mode decomposition (EEMD), which is an effective method for adaptively decomposing the vibration signal into different bands of signal components, termed intrinsic mode functions (IMFs). An optimization method was designed to automatically select appropriate EEMD parameters for the analyzed signal, and in particular to select the appropriate level of the added white noise in the EEMD method. An index termed the relative root-mean-square error was used to evaluate the decomposition performances under different noise levels to find the optimal level. After applying the optimal EEMD method to a vibration signal, the IMF relating to the bearing fault can be extracted from the original vibration signal. Compressing this signal component obtains a much smaller proportion of data samples to be retained for transmission and further reconstruction. The proposed compression method were also compared with the popular wavelet compression method. Experimental results demonstrate that the optimization of EEMD parameters can automatically find appropriate EEMD parameters for the analyzed signals, and the IMF-based compression method provides a higher compression ratio, while retaining the bearing defect

A comparison of penetration and damage caused by different types of arrowheads on loose and tight fit clothing.

Science.gov (United States)

MacPhee, Nichole; Savage, Anne; Noton, Nikolas; Beattie, Eilidh; Milne, Louise; Fraser, Joanna

2018-03-01

Bows and arrows are used more for recreation, sport and hunting in the Western world and tend not to be as popular a weapon as firearms or knives. Yet there are still injuries and fatalities caused by these low-velocity weapons due to their availability to the public and that a licence is not required to own them. This study aimed to highlight the penetration capabilities of aluminium arrows into soft tissue and bones in the presence of clothing. Further from that, how the type and fit of clothing as well as arrowhead type contribute to penetration capacity. In this study ballistic gelatine blocks (non-clothed and loose fit or tight fit clothed) were shot using a 24lb weight draw recurve bow and aluminium arrows accompanied by four different arrowheads (bullet, judo, blunt and broadhead). The penetration capability of aluminium arrows was examined, and the depth of penetration was found to be dependent on the type of arrowhead used as well as by the type and fit or lack thereof of the clothing covering the block. Loose fit clothing reduced penetration with half of the samples, reducing penetration capacity by percentages between 0% and 98.33%, at a range of 10m. While the remaining half of the samples covered with tight clothing led to reductions in penetration of between 14.06% and 94.12%. The damage to the clothing and the gelatine (puncturing, cutting and tearing) was affected by the shape of the arrowhead, with the least damaged caused by the blunt arrowheads and the most by the broadhead arrows. Clothing fibres were also at times found within the projectile tract within the gelatine showing potential for subsequent infection of an individual with an arrow wound. Ribs, femur bones and spinal columns encased in some of the gelatine blocks all showed varying levels of damage, with the most and obvious damage being exhibited by the ribs and spinal column. The information gleaned from the damage to clothing, gelatine blocks and bones could potentially be useful for

[Meeting point Stewart. Buffer bases, base excess and strong ions].

Science.gov (United States)

Lang, W

2007-04-01

Development of a two-buffer model which simulates the acid-base properties of blood and allows comparison of the different acidbase concepts according to Stewart and to Siggaard-Andersen. The two-buffer model consisted of different aqueous solutions of bicarbonate/CO(2) (pCO(2), sCO(2), pK(1)), HEPES buffer (A(tot), pK(a)) and electrolytes. These were used to calculate the pH from the independent variables according to Stewart - strong ion difference (SID), pCO(2) and total concentration of the weak acids (A(tot)) - from which all other dependent variables (cHCO(3)(-), cA(-), BB, BE) were obtained and compared with the measured values. The normal pH (7.408) was calculated from the normal values for SID (48 mmol/l), pCO(2) (40 mmHg) and A(tot) (45.2 mmol/l) and agreed perfectly with the measured value (7.409+/-0.001). This was also valid for all calculated and measured pH values when the SID was varied: non-respiratory alkalosis ( upward arrow) or acidosis ( downward arrow), pCO(2):respiratory acidosis ( upward arrow) or alkalosis ( downward arrow) and A(tot):hyperproteinemic acidosis ( upward arrow) or hypoproteinemic alkalosis ( downward arrow) were varied and the sum of the buffer bases (BB) was always equal to the SID. All changes and hence BE were also equal, providing that A(tot) was normal. This was not the case, however, if A(tot) was outside the normal range, when BE was then the difference from the normal BB at the respective reference point. Whereas the deviation of the measured pCO(2) was acceptable (1.74+/-0.86 mmHg), this was not the case for the SID (-6.18+/-3.58 mmol/l) calculated from the measured ion concentrations (Na, K, Ca, Cl). Despite controversial discussions, both concepts are much closer than might be expected. Whereas in the Stewart approach the focus of analysis is on plasma, with the Siggaard-Andersen approach it is on blood. Hence, a combined analysis of the blood gases (pH, pCO(2), pO(2), sO(2), cHb, BE) and of the strong ion gap (SIG

Signals structural analysis and processing: application to acoustic signals recorded during sodium boiling in a nuclear reactor

International Nuclear Information System (INIS)

Rodriguez, J.

1986-02-01

An acoustic system that uses examples to learn the structure of specific signals linked to a corresponding class of physical phenomena, and classify an unknown signal (possibly with noise present) into one of the learned classes is presented. The first stage consists of smoothing the data. The signal is represented as a trace according to background and event. To learn the structures in each class, smoothed, segmented signals are used. For classification, three operations to modify the signal so that it perfectly verifies the model description are available [fr

Exponential signaling gain at the receptor level enhances signal-to-noise ratio in bacterial chemotaxis.

Directory of Open Access Journals (Sweden)

Silke Neumann

Full Text Available Cellular signaling systems show astonishing precision in their response to external stimuli despite strong fluctuations in the molecular components that determine pathway activity. To control the effects of noise on signaling most efficiently, living cells employ compensatory mechanisms that reach from simple negative feedback loops to robustly designed signaling architectures. Here, we report on a novel control mechanism that allows living cells to keep precision in their signaling characteristics - stationary pathway output, response amplitude, and relaxation time - in the presence of strong intracellular perturbations. The concept relies on the surprising fact that for systems showing perfect adaptation an exponential signal amplification at the receptor level suffices to eliminate slowly varying multiplicative noise. To show this mechanism at work in living systems, we quantified the response dynamics of the E. coli chemotaxis network after genetically perturbing the information flux between upstream and downstream signaling components. We give strong evidence that this signaling system results in dynamic invariance of the activated response regulator against multiplicative intracellular noise. We further demonstrate that for environmental conditions, for which precision in chemosensing is crucial, the invariant response behavior results in highest chemotactic efficiency. Our results resolve several puzzling features of the chemotaxis pathway that are widely conserved across prokaryotes but so far could not be attributed any functional role.

Social knowledge and signals in primates.

Science.gov (United States)

Bergman, Thore J; Sheehan, Michael J

2013-07-01

Primates are notable for having a rich and detailed understanding of their social environment and there has been great interest in the evolution and function of social knowledge in primates. Indeed, primates have been shown to have impressive understandings of not only other group members but also the complex relationships among them. To be useful, however, social knowledge requires memories from previous encounters and observations about individual traits that are stable. Here, we argue that social systems or traits that make social knowledge more costly or less accurate will favor signals that either supplement or replace social knowledge. Thus, the relationship between signals and social knowledge can be complementary or antagonistic depending on the type of signal. Our goal in this review is to elucidate the relationships between signals and social knowledge in primates. We categorize signals into three types, each with different relationships to social knowledge. (1) Identity signals directly facilitate social knowledge, (2) current-state signals supplement information gained through social knowledge, and (3) badges of status replace social knowledge. Primates rely extensively on identity information, but it remains to be determined to what extent this is based on receiver perception of individual variation or senders using identity signals. Primates frequently utilize current-state signals including signals of intent to augment their interactions with familiar individuals. Badges of status are rare in primates, and the cases where they are used point to a functional and evolutionary trade-off between badges of status and social knowledge. However, the nature of this relationship needs further exploration. © 2012 Wiley Periodicals, Inc.

"Utilizing" signal detection theory.

Science.gov (United States)

Lynn, Spencer K; Barrett, Lisa Feldman

2014-09-01

What do inferring what a person is thinking or feeling, judging a defendant's guilt, and navigating a dimly lit room have in common? They involve perceptual uncertainty (e.g., a scowling face might indicate anger or concentration, for which different responses are appropriate) and behavioral risk (e.g., a cost to making the wrong response). Signal detection theory describes these types of decisions. In this tutorial, we show how incorporating the economic concept of utility allows signal detection theory to serve as a model of optimal decision making, going beyond its common use as an analytic method. This utility approach to signal detection theory clarifies otherwise enigmatic influences of perceptual uncertainty on measures of decision-making performance (accuracy and optimality) and on behavior (an inverse relationship between bias magnitude and sensitivity optimizes utility). A "utilized" signal detection theory offers the possibility of expanding the phenomena that can be understood within a decision-making framework. © The Author(s) 2014.

Evaluation of diagnostic thresholds dependability for tribologic signals received in the environment disturbed by vibroacoustic and functional signals

Directory of Open Access Journals (Sweden)

Lindstedt Paweł

2015-12-01

Full Text Available Determination of dependable diagnostic thresholds for tribologic signals received e.g. from antifriction bearings (in particular for insufficient number of measurements, only 4÷5 is a really difficult task due to complexity of working environment where such bearings are operated. Typical working environment for such objects must take account for operation time under various working conditions and accompanying (and disturbing signals, e.g. vibroacoustic ones. The sought assessment of the relationship between diagnostic signals and environmental noise can be determined from convolution of both diagnostic and environments signals that make up the complete set of received information. The convolution of these two series of signals can be obtained from an algorithm based on the Cauchy product. Then one has to find the coherence factor and the square of amplitude gain for the set of diagnostic signals with reference to various sets of signals received from environment, which makes it possible to evaluate cohesion of the investigated series of signals, thus their suitability to determine diagnostic threshold for tribologic signals intended for the analysis.

Phase synchronization of instrumental music signals

Science.gov (United States)

Mukherjee, Sayan; Palit, Sanjay Kumar; Banerjee, Santo; Ariffin, M. R. K.; Bhattacharya, D. K.

2014-06-01

Signal analysis is one of the finest scientific techniques in communication theory. Some quantitative and qualitative measures describe the pattern of a music signal, vary from one to another. Same musical recital, when played by different instrumentalists, generates different types of music patterns. The reason behind various patterns is the psycho-acoustic measures - Dynamics, Timber, Tonality and Rhythm, varies in each time. However, the psycho-acoustic study of the music signals does not reveal any idea about the similarity between the signals. For such cases, study of synchronization of long-term nonlinear dynamics may provide effective results. In this context, phase synchronization (PS) is one of the measures to show synchronization between two non-identical signals. In fact, it is very critical to investigate any other kind of synchronization for experimental condition, because those are completely non identical signals. Also, there exists equivalence between the phases and the distances of the diagonal line in Recurrence plot (RP) of the signals, which is quantifiable by the recurrence quantification measure τ-recurrence rate. This paper considers two nonlinear music signals based on same raga played by two eminent sitar instrumentalists as two non-identical sources. The psycho-acoustic study shows how the Dynamics, Timber, Tonality and Rhythm vary for the two music signals. Then, long term analysis in the form of phase space reconstruction is performed, which reveals the chaotic phase spaces for both the signals. From the RP of both the phase spaces, τ-recurrence rate is calculated. Finally by the correlation of normalized tau-recurrence rate of their 3D phase spaces and the PS of the two music signals has been established. The numerical results well support the analysis.

Quantum signaling game

International Nuclear Information System (INIS)

Frackiewicz, Piotr

2014-01-01

We present a quantum approach to a signaling game; a special kind of extensive game of incomplete information. Our model is based on quantum schemes for games in strategic form where players perform unitary operators on their own qubits of some fixed initial state and the payoff function is given by a measurement on the resulting final state. We show that the quantum game induced by our scheme coincides with a signaling game as a special case and outputs nonclassical results in general. As an example, we consider a quantum extension of the signaling game in which the chance move is a three-parameter unitary operator whereas the players' actions are equivalent to classical ones. In this case, we study the game in terms of Nash equilibria and refine the pure Nash equilibria adapting to the quantum game the notion of a weak perfect Bayesian equilibrium. (paper)

Selection-Mutation Dynamics of Signaling Games

Directory of Open Access Journals (Sweden)

Josef Hofbauer

2015-01-01

Full Text Available We study the structure of the rest points of signaling games and their dynamic behavior under selection-mutation dynamics by taking the case of three signals as our canonical example. Many rest points of the replicator dynamics of signaling games are not isolated and, therefore, not robust under perturbations. However, some of them attract open sets of initial conditions. We prove the existence of certain rest points of the selection-mutation dynamics close to Nash equilibria of the signaling game and show that all but the perturbed rest points close to strict Nash equilibria are dynamically unstable. This is an important result for the evolution of signaling behavior, since it shows that the second-order forces that are governed by mutation can increase the chances of successful signaling.

Long-distance signalling in plant defence.

Science.gov (United States)

Heil, Martin; Ton, Jurriaan

2008-06-01

Plants use inducible defence mechanisms to fend off harmful organisms. Resistance that is induced in response to local attack is often expressed systemically, that is, in organs that are not yet damaged. In the search for translocated defence signals, biochemical studies follow the physical movement of putative signals, and grafting experiments use mutants that are impaired in the production or perception of these signals. Long-distance signals can directly activate defence or can prime for the stronger and faster induction of defence. Historically, research has focused on the vascular transport of signalling metabolites, but volatiles can play a crucial role as well. We compare the advantages and constraints of vascular and airborne signals for the plant, and discuss how they can act in synergy to achieve optimised resistance in distal plant parts.

Origins of Beta Tantalum in Sputtered Coatings

National Research Council Canada - National Science Library

Mulligan, C

2001-01-01

.... Some of the most recent work has attempted to relate the energetics (i.e., atom/ion energy) of the plasma to the alpha right arrow beta transition. It has been shown that the energetics of the plasma can relate to the most crucial sputtering parameters. The most significant feature of the use of plasma energy to explain the alpha right arrow beta transition is that it relates the formation of beta-tantalum to a quantifiable measure.

The Formation and Fate of Internal Waves in the South China Sea

Science.gov (United States)

2015-11-05

processes in theLuzonStrait. a, Time-mean total energy flux from the near-field numerical model (white arrows) and field measurements ( coloured arrows...breaking at the location indicated in a by the green star, corresponding to times T0 and T1 indicated in f. Colours and lines in b and c indicate east...numerical dispersion in nonhydrostatic ocean modeling. Ocean Model. 40, 72–86 (2011). Acknowledgements This article is dedicated to the memory of author

Photonic Ultra-Wideband 781.25-Mb/s Signal Generation and Transmission Incorporating Digital Signal Processing Detection

DEFF Research Database (Denmark)

Gibbon, Timothy Braidwood; Yu, Xianbin; Tafur Monroy, Idelfonso

2009-01-01

The generation of photonic ultra-wideband (UWB) impulse signals using an uncooled distributed-feedback laser is proposed. For the first time, we experimentally demonstrate bit-for-bit digital signal processing (DSP) bit-error-rate measurements for transmission of a 781.25-Mb/s photonic UWB signal...

Foreground Subtraction and Signal reconstruction in redshifted 21cm Global Signal Experiments using Artificial Neural Networks

Science.gov (United States)

Choudhury, Madhurima; Datta, Abhirup

2018-05-01

Observations of HI 21cm transition line is a promising probe into the Dark Ages and Epoch-of-Reionization. Detection of this redshifted 21cm signal is one of the key science goal for several upcoming low-frequency radio telescopes like HERA, SKA and DARE. Other global signal experiments include EDGES, LEDA, BIGHORNS, SCI-HI, SARAS. One of the major challenges for the detection of this signal is the accuracy of the foreground source removal. Several novel techniques have been explored already to remove bright foregrounds from both interferometric as well as total power experiments. Here, we present preliminary results from our investigation on application of ANN to detect 21cm global signal amidst bright galactic foreground. Following the formalism of representing the global 21cm signal by 'tanh' model, this study finds that the global 21cm signal parameters can be accurately determined even in the presence of bright foregrounds represented by 3rd order log-polynomial or higher.

Digital Signal Processing applied to Physical Signals

CERN Document Server

Alberto, Diego; Musa, L

2011-01-01

It is well known that many of the scientific and technological discoveries of the XXI century will depend on the capability of processing and understanding a huge quantity of data. With the advent of the digital era, a fully digital and automated treatment can be designed and performed. From data mining to data compression, from signal elaboration to noise reduction, a processing is essential to manage and enhance features of interest after every data acquisition (DAQ) session. In the near future, science will go towards interdisciplinary research. In this work there will be given an example of the application of signal processing to different fields of Physics from nuclear particle detectors to biomedical examinations. In Chapter 1 a brief description of the collaborations that allowed this thesis is given, together with a list of the publications co-produced by the author in these three years. The most important notations, definitions and acronyms used in the work are also provided. In Chapter 2, the last r...

Blind Signal Classification via Spare Coding

Science.gov (United States)

2016-04-10

Blind Signal Classification via Sparse Coding Youngjune Gwon MIT Lincoln Laboratory gyj@ll.mit.edu Siamak Dastangoo MIT Lincoln Laboratory sia...achieve blind signal classification with no prior knowledge about signals (e.g., MCS, pulse shaping) in an arbitrary RF channel. Since modulated RF...classification method. Our results indicate that we can separate different classes of digitally modulated signals from blind sampling with 70.3% recall and 24.6

Network modeling reveals prevalent negative regulatory relationships between signaling sectors in Arabidopsis immune signaling.

Directory of Open Access Journals (Sweden)

Masanao Sato

Full Text Available Biological signaling processes may be mediated by complex networks in which network components and network sectors interact with each other in complex ways. Studies of complex networks benefit from approaches in which the roles of individual components are considered in the context of the network. The plant immune signaling network, which controls inducible responses to pathogen attack, is such a complex network. We studied the Arabidopsis immune signaling network upon challenge with a strain of the bacterial pathogen Pseudomonas syringae expressing the effector protein AvrRpt2 (Pto DC3000 AvrRpt2. This bacterial strain feeds multiple inputs into the signaling network, allowing many parts of the network to be activated at once. mRNA profiles for 571 immune response genes of 22 Arabidopsis immunity mutants and wild type were collected 6 hours after inoculation with Pto DC3000 AvrRpt2. The mRNA profiles were analyzed as detailed descriptions of changes in the network state resulting from the genetic perturbations. Regulatory relationships among the genes corresponding to the mutations were inferred by recursively applying a non-linear dimensionality reduction procedure to the mRNA profile data. The resulting static network model accurately predicted 23 of 25 regulatory relationships reported in the literature, suggesting that predictions of novel regulatory relationships are also accurate. The network model revealed two striking features: (i the components of the network are highly interconnected; and (ii negative regulatory relationships are common between signaling sectors. Complex regulatory relationships, including a novel negative regulatory relationship between the early microbe-associated molecular pattern-triggered signaling sectors and the salicylic acid sector, were further validated. We propose that prevalent negative regulatory relationships among the signaling sectors make the plant immune signaling network a "sector

Signal analysis for failure detection

International Nuclear Information System (INIS)

Parpaglione, M.C.; Perez, L.V.; Rubio, D.A.; Czibener, D.; D'Attellis, C.E.; Brudny, P.I.; Ruzzante, J.E.

1994-01-01

Several methods for analysis of acoustic emission signals are presented. They are mainly oriented to detection of changes in noisy signals and characterization of higher amplitude discrete pulses or bursts. The aim was to relate changes and events with failure, crack or wear in materials, being the final goal to obtain automatic means of detecting such changes and/or events. Performance evaluation was made using both simulated and laboratory test signals. The methods being presented are the following: 1. Application of the Hopfield Neural Network (NN) model for classifying faults in pipes and detecting wear of a bearing. 2. Application of the Kohonnen and Back Propagation Neural Network model for the same problem. 3. Application of Kalman filtering to determine time occurrence of bursts. 4. Application of a bank of Kalman filters (KF) for failure detection in pipes. 5. Study of amplitude distribution of signals for detecting changes in their shape. 6. Application of the entropy distance to measure differences between signals. (author). 10 refs, 11 figs

Signal processing for passive detection and classification of underwater acoustic signals

Science.gov (United States)

Chung, Kil Woo

2011-12-01

This dissertation examines signal processing for passive detection, classification and tracking of underwater acoustic signals for improving port security and the security of coastal and offshore operations. First, we consider the problem of passive acoustic detection of a diver in a shallow water environment. A frequency-domain multi-band matched-filter approach to swimmer detection is presented. The idea is to break the frequency contents of the hydrophone signals into multiple narrow frequency bands, followed by time averaged (about half of a second) energy calculation over each band. Then, spectra composed of such energy samples over the chosen frequency bands are correlated to form a decision variable. The frequency bands with highest Signal/Noise ratio are used for detection. The performance of the proposed approach is demonstrated for experimental data collected for a diver in the Hudson River. We also propose a new referenceless frequency-domain multi-band detector which, unlike other reference-based detectors, does not require a diver specific signature. Instead, our detector matches to a general feature of the diver spectrum in the high frequency range: the spectrum is roughly periodic in time and approximately flat when the diver exhales. The performance of the proposed approach is demonstrated by using experimental data collected from the Hudson River. Moreover, we present detection, classification and tracking of small vessel signals. Hydroacoustic sensors can be applied for the detection of noise generated by vessels, and this noise can be used for vessel detection, classification and tracking. This dissertation presents recent improvements aimed at the measurement and separation of ship DEMON (Detection of Envelope Modulation on Noise) acoustic signatures in busy harbor conditions. Ship signature measurements were conducted in the Hudson River and NY Harbor. The DEMON spectra demonstrated much better temporal stability compared with the full ship

Signal modulation as a mechanism for handicap disposal

Science.gov (United States)

Gavassa, Sat; Silva, Ana C.; Gonzalez, Emmanuel; Stoddard, Philip K.

2012-01-01

Signal honesty may be compromised when heightened competition provides incentive for signal exaggeration. Some degree of honesty might be maintained by intrinsic handicap costs on signalling or through imposition of extrinsic costs, such as social punishment of low quality cheaters. Thus, theory predicts a delicate balance between signal enhancement and signal reliability that varies with degree of social competition, handicap cost, and social cost. We investigated whether male sexual signals of the electric fish Brachyhypopomus gauderio would become less reliable predictors of body length when competition provides incentives for males to boost electric signal amplitude. As expected, social competition under natural field conditions and in controlled lab experiments drove males to enhance their signals. However, signal enhancement improved the reliability of the information conveyed by the signal, as revealed in the tightening of the relationship between signal amplitude and body length. Signal augmentation in male B. gauderio was independent of body length, and thus appeared not to be curtailed through punishment of low quality (small) individuals. Rather, all individuals boosted their signals under high competition, but those whose signals were farthest from the predicted value under low competition boosted signal amplitude the most. By elimination, intrinsic handicap cost of signal production, rather than extrinsic social cost, appears to be the basis for the unexpected reinforcement of electric signal honesty under social competition. Signal modulation may provide its greatest advantage to the signaller as a mechanism for handicap disposal under low competition rather than as a mechanism for exaggeration of quality under high competition. PMID:22665940

Digital signal processing with kernel methods

CERN Document Server

Rojo-Alvarez, José Luis; Muñoz-Marí, Jordi; Camps-Valls, Gustavo

2018-01-01

A realistic and comprehensive review of joint approaches to machine learning and signal processing algorithms, with application to communications, multimedia, and biomedical engineering systems Digital Signal Processing with Kernel Methods reviews the milestones in the mixing of classical digital signal processing models and advanced kernel machines statistical learning tools. It explains the fundamental concepts from both fields of machine learning and signal processing so that readers can quickly get up to speed in order to begin developing the concepts and application software in their own research. Digital Signal Processing with Kernel Methods provides a comprehensive overview of kernel methods in signal processing, without restriction to any application field. It also offers example applications and detailed benchmarking experiments with real and synthetic datasets throughout. Readers can find further worked examples with Matlab source code on a website developed by the authors. * Presents the necess...

Digital storage of repeated signals

International Nuclear Information System (INIS)

Prozorov, S.P.

1984-01-01

An independent digital storage system designed for repeated signal discrimination from background noises is described. The signal averaging is performed off-line in the real time mode by means of multiple selection of the investigated signal and integration in each point. Digital values are added in a simple summator and the result is recorded the storage device with the volume of 1024X20 bit from where it can be output on an oscillograph, a plotter or transmitted to a compUter for subsequent processing. The described storage is reliable and simple device on one base of which the systems for the nuclear magnetic resonapce signal acquisition in different experiments are developed

Advanced digital signal processing and noise reduction

CERN Document Server

Vaseghi, Saeed V

2008-01-01

Digital signal processing plays a central role in the development of modern communication and information processing systems. The theory and application of signal processing is concerned with the identification, modelling and utilisation of patterns and structures in a signal process. The observation signals are often distorted, incomplete and noisy and therefore noise reduction, the removal of channel distortion, and replacement of lost samples are important parts of a signal processing system. The fourth edition of Advanced Digital Signal Processing and Noise Reduction updates an

Problems of the Synthesis of Radar Signals,

Science.gov (United States)

1981-05-14

recorded, finding out approximation/approach to certain signal x(t) , logical to ascribe a(w.) the phase spc -ctrum cf signal xft). the diffsrences...of the given cne). e will r~ spc -.ively d-stirguish se- cf Ch, signals of fixed Fericd cf rims X. frcm the sst cf Ch. signals of drbitrary duration X...XeXP~j IjM+a .t * An error in asymptotic soluticr can be ccnsidered now, being congruent/ squating found ChM signal z.,g(t) with ganerating signal

DMPD: When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transduction. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18631453 When signaling pathways collide: positive and negative regulation of toll-...uction. PubmedID 18631453 Title When signaling pathways collide: positive and neg...l) Show When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transd...likereceptor signal transduction. O'Neill LA. Immunity. 2008 Jul 18;29(1):12-20. (.png) (.svg) (.html) (.csm

Hedgehog Signaling in Endochondral Ossification

Directory of Open Access Journals (Sweden)

Shinsuke Ohba

2016-06-01

Full Text Available Hedgehog (Hh signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator. Among three Hh proteins in mammals, Indian hedgehog (Ihh is known to work as a major Hh input that induces biological impact of Hh signaling on the endochondral ossification. Ihh is expressed in prehypertrophic and hypertrophic chondrocytes of developing endochondral bones. Genetic studies so far have demonstrated that the Ihh-mediated activation of Hh signaling synchronizes chondrogenesis and osteogenesis during endochondral ossification by regulating the following processes: (1 chondrocyte differentiation; (2 chondrocyte proliferation; and (3 specification of bone-forming osteoblasts. Ihh not only forms a negative feedback loop with parathyroid hormone-related protein (PTHrP to maintain the growth plate length, but also directly promotes chondrocyte propagation. Ihh input is required for the specification of progenitors into osteoblast precursors. The combinatorial approaches of genome-wide analyses and mouse genetics will facilitate understanding of the regulatory mechanisms underlying the roles of Hh signaling in endochondral ossification, providing genome-level evidence of the potential of Hh signaling for the treatment of skeletal disorders.

Hedgehog Signaling in Endochondral Ossification

Science.gov (United States)

Ohba, Shinsuke

2016-01-01

Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator. Among three Hh proteins in mammals, Indian hedgehog (Ihh) is known to work as a major Hh input that induces biological impact of Hh signaling on the endochondral ossification. Ihh is expressed in prehypertrophic and hypertrophic chondrocytes of developing endochondral bones. Genetic studies so far have demonstrated that the Ihh-mediated activation of Hh signaling synchronizes chondrogenesis and osteogenesis during endochondral ossification by regulating the following processes: (1) chondrocyte differentiation; (2) chondrocyte proliferation; and (3) specification of bone-forming osteoblasts. Ihh not only forms a negative feedback loop with parathyroid hormone-related protein (PTHrP) to maintain the growth plate length, but also directly promotes chondrocyte propagation. Ihh input is required for the specification of progenitors into osteoblast precursors. The combinatorial approaches of genome-wide analyses and mouse genetics will facilitate understanding of the regulatory mechanisms underlying the roles of Hh signaling in endochondral ossification, providing genome-level evidence of the potential of Hh signaling for the treatment of skeletal disorders. PMID:29615586

Drought Signaling in Plants

Indian Academy of Sciences (India)

depending upon the source and nature of signaling: (i) hormone signal, (ii) .... plants to regulate the rate of transpiration through minor structural .... cell has to keep spending energy (in the form of A TP) to maintain a .... enzymes and proteins in the regulation of cellular metabolism can be determined by either inactivating.

Flanking signal and mature peptide residues influence signal peptide cleavage

Directory of Open Access Journals (Sweden)

Ranganathan Shoba

2008-12-01

Full Text Available Abstract Background Signal peptides (SPs mediate the targeting of secretory precursor proteins to the correct subcellular compartments in prokaryotes and eukaryotes. Identifying these transient peptides is crucial to the medical, food and beverage and biotechnology industries yet our understanding of these peptides remains limited. This paper examines the most common type of signal peptides cleavable by the endoprotease signal peptidase I (SPase I, and the residues flanking the cleavage sites of three groups of signal peptide sequences, namely (i eukaryotes (Euk (ii Gram-positive (Gram+ bacteria, and (iii Gram-negative (Gram- bacteria. Results In this study, 2352 secretory peptide sequences from a variety of organisms with amino-terminal SPs are extracted from the manually curated SPdb database for analysis based on physicochemical properties such as pI, aliphatic index, GRAVY score, hydrophobicity, net charge and position-specific residue preferences. Our findings show that the three groups share several similarities in general, but they display distinctive features upon examination in terms of their amino acid compositions and frequencies, and various physico-chemical properties. Thus, analysis or prediction of their sequences should be separated and treated as distinct groups. Conclusion We conclude that the peptide segment recognized by SPase I extends to the start of the mature protein to a limited extent, upon our survey of the amino acid residues surrounding the cleavage processing site. These flanking residues possibly influence the cleavage processing and contribute to non-canonical cleavage sites. Our findings are applicable in defining more accurate prediction tools for recognition and identification of cleavage site of SPs.

Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3).

Science.gov (United States)

Branham-O'Connor, Melissa; Robichaux, William G; Zhang, Xian-Kui; Cho, Hyeseon; Kehrl, John H; Lanier, Stephen M; Blumer, Joe B

2014-04-11

Activator of G-protein signaling 3 (AGS3, gene name G-protein signaling modulator-1, Gpsm1), an accessory protein for G-protein signaling, has functional roles in the kidney and CNS. Here we show that AGS3 is expressed in spleen, thymus, and bone marrow-derived dendritic cells, and is up-regulated upon leukocyte activation. We explored the role of AGS3 in immune cell function by characterizing chemokine receptor signaling in leukocytes from mice lacking AGS3. No obvious differences in lymphocyte subsets were observed. Interestingly, however, AGS3-null B and T lymphocytes and bone marrow-derived dendritic cells exhibited significant chemotactic defects as well as reductions in chemokine-stimulated calcium mobilization and altered ERK and Akt activation. These studies indicate a role for AGS3 in the regulation of G-protein signaling in the immune system, providing unexpected venues for the potential development of therapeutic agents that modulate immune function by targeting these regulatory mechanisms.

Flash signal evolution in Photinus fireflies: character displacement and signal exploitation in a visual communication system.

Science.gov (United States)

Stanger-Hall, Kathrin F; Lloyd, James E

2015-03-01

Animal communication is an intriguing topic in evolutionary biology. In this comprehensive study of visual signal evolution, we used a phylogenetic approach to study the evolution of the flash communication system of North American fireflies. The North American firefly genus Photinus contains 35 described species with simple ON-OFF visual signals, and information on habitat types, sympatric congeners, and predators. This makes them an ideal study system to test hypotheses on the evolution of male and female visual signal traits. Our analysis of 34 Photinus species suggests two temporal pattern generators: one for flash duration and one for flash intervals. Reproductive character displacement was a main factor for signal divergence in male flash duration among sympatric Photinus species. Male flash pattern intervals (i.e., the duration of the dark periods between signals) were positively correlated with the number of sympatric Photuris fireflies, which include predators of Photinus. Females of different Photinus species differ in their response preferences to male traits. As in other communication systems, firefly male sexual signals seem to be a compromise between optimizing mating success (sexual selection) and minimizing predation risk (natural selection). An integrative model for Photinus signal evolution is proposed. © 2015 The Author(s).

Short-term visual memory for location in depth: A U-shaped function of time.

Science.gov (United States)

Reeves, Adam; Lei, Quan

2017-10-01

Short-term visual memory was studied by displaying arrays of four or five numerals, each numeral in its own depth plane, followed after various delays by an arrow cue shown in one of the depth planes. Subjects reported the numeral at the depth cued by the arrow. Accuracy fell with increasing cue delay for the first 500 ms or so, and then recovered almost fully. This dipping pattern contrasts with the usual iconic decay observed for memory traces. The dip occurred with or without a verbal or color-shape retention load on working memory. In contrast, accuracy did not change with delay when a tonal cue replaced the arrow cue. We hypothesized that information concerning the depths of the numerals decays over time in sensory memory, but that cued recall is aided later on by transfer to a visual memory specialized for depth. This transfer is sufficiently rapid with a tonal cue to compensate for the sensory decay, but it is slowed by the need to tag the arrow cue's depth relative to the depths of the numerals, exposing a dip when sensation has decayed and transfer is not yet complete. A model with a fixed rate of sensory decay and varied transfer rates across individuals captures the dip as well as the cue modality effect.

Evaluation of blind signal separation methods

NARCIS (Netherlands)

Schobben, D.W.E.; Torkkola, K.; Smaragdis, P.

1999-01-01

Recently many new Blind Signal Separation BSS algorithms have been introduced Authors evaluate the performance of their algorithms in various ways Among these are speech recognition rates plots of separated signals plots of cascaded mixingunmixing impulse responses and signal to noise ratios Clearly

49 CFR 236.804 - Signal, block.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Signal, block. 236.804 Section 236.804 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Signal, block. A roadway signal operated either automatically or manually at the entrance to a block. ...

Phase noise mitigation of QPSK signal utilizing phase-locked multiplexing of signal harmonics and amplitude saturation.

Science.gov (United States)

Mohajerin-Ariaei, Amirhossein; Ziyadi, Morteza; Chitgarha, Mohammad Reza; Almaiman, Ahmed; Cao, Yinwen; Shamee, Bishara; Yang, Jeng-Yuan; Akasaka, Youichi; Sekiya, Motoyoshi; Takasaka, Shigehiro; Sugizaki, Ryuichi; Touch, Joseph D; Tur, Moshe; Langrock, Carsten; Fejer, Martin M; Willner, Alan E

2015-07-15

We demonstrate an all-optical phase noise mitigation scheme based on the generation, delay, and coherent summation of higher order signal harmonics. The signal, its third-order harmonic, and their corresponding delayed variant conjugates create a staircase phase-transfer function that quantizes the phase of quadrature-phase-shift-keying (QPSK) signal to mitigate phase noise. The signal and the harmonics are automatically phase-locked multiplexed, avoiding the need for phase-based feedback loop and injection locking to maintain coherency. The residual phase noise converts to amplitude noise in the quantizer stage, which is suppressed by parametric amplification in the saturation regime. Phase noise reduction of ∼40% and OSNR-gain of ∼3  dB at BER 10(-3) are experimentally demonstrated for 20- and 30-Gbaud QPSK input signals.

Liquid Argon TPC Signal Formation, Signal Processing and Hit Reconstruction

Energy Technology Data Exchange (ETDEWEB)

Baller, Bruce [Fermilab

2017-03-11

This document describes the early stage of the reconstruction chain that was developed for the ArgoNeuT and MicroBooNE experiments at Fermilab. These experiments study accelerator neutrino interactions that occur in a Liquid Argon Time Projection Chamber. Reconstructing the properties of particles produced in these interactions requires knowledge of the micro-physics processes that affect the creation and transport of ionization electrons to the readout system. A wire signal deconvolution technique was developed to convert wire signals to a standard form for hit reconstruction, to remove artifacts in the electronics chain and to remove coherent noise.

Automatic modulation recognition of communication signals

CERN Document Server

Azzouz, Elsayed Elsayed

1996-01-01

Automatic modulation recognition is a rapidly evolving area of signal analysis. In recent years, interest from the academic and military research institutes has focused around the research and development of modulation recognition algorithms. Any communication intelligence (COMINT) system comprises three main blocks: receiver front-end, modulation recogniser and output stage. Considerable work has been done in the area of receiver front-ends. The work at the output stage is concerned with information extraction, recording and exploitation and begins with signal demodulation, that requires accurate knowledge about the signal modulation type. There are, however, two main reasons for knowing the current modulation type of a signal; to preserve the signal information content and to decide upon the suitable counter action, such as jamming. Automatic Modulation Recognition of Communications Signals describes in depth this modulation recognition process. Drawing on several years of research, the authors provide a cr...

Electronic signal conditioning

CERN Document Server

NEWBY, BRUCE

1994-01-01

At technician level, brief references to signal conditioning crop up in a fragmented way in various textbooks, but there has been no single textbook, until now!More advanced texts do exist but they are more mathematical and presuppose a higher level of understanding of electronics and statistics. Electronic Signal Conditioning is designed for HNC/D students and City & Guilds Electronics Servicing 2240 Parts 2 & 3. It will also be useful for BTEC National, Advanced GNVQ, A-level electronics and introductory courses at degree level.

Genomic signal processing

CERN Document Server

Shmulevich, Ilya

2007-01-01

Genomic signal processing (GSP) can be defined as the analysis, processing, and use of genomic signals to gain biological knowledge, and the translation of that knowledge into systems-based applications that can be used to diagnose and treat genetic diseases. Situated at the crossroads of engineering, biology, mathematics, statistics, and computer science, GSP requires the development of both nonlinear dynamical models that adequately represent genomic regulation, and diagnostic and therapeutic tools based on these models. This book facilitates these developments by providing rigorous mathema

Multivariate Analysis for the Processing of Signals

Directory of Open Access Journals (Sweden)

Beattie J.R.

2014-01-01

Full Text Available Real-world experiments are becoming increasingly more complex, needing techniques capable of tracking this complexity. Signal based measurements are often used to capture this complexity, where a signal is a record of a sample’s response to a parameter (e.g. time, displacement, voltage, wavelength that is varied over a range of values. In signals the responses at each value of the varied parameter are related to each other, depending on the composition or state sample being measured. Since signals contain multiple information points, they have rich information content but are generally complex to comprehend. Multivariate Analysis (MA has profoundly transformed their analysis by allowing gross simplification of the tangled web of variation. In addition MA has also provided the advantage of being much more robust to the influence of noise than univariate methods of analysis. In recent years, there has been a growing awareness that the nature of the multivariate methods allows exploitation of its benefits for purposes other than data analysis, such as pre-processing of signals with the aim of eliminating irrelevant variations prior to analysis of the signal of interest. It has been shown that exploiting multivariate data reduction in an appropriate way can allow high fidelity denoising (removal of irreproducible non-signals, consistent and reproducible noise-insensitive correction of baseline distortions (removal of reproducible non-signals, accurate elimination of interfering signals (removal of reproducible but unwanted signals and the standardisation of signal amplitude fluctuations. At present, the field is relatively small but the possibilities for much wider application are considerable. Where signal properties are suitable for MA (such as the signal being stationary along the x-axis, these signal based corrections have the potential to be highly reproducible, and highly adaptable and are applicable in situations where the data is noisy or

Fundamentals of statistical signal processing

CERN Document Server

Kay, Steven M

1993-01-01

A unified presentation of parameter estimation for those involved in the design and implementation of statistical signal processing algorithms. Covers important approaches to obtaining an optimal estimator and analyzing its performance; and includes numerous examples as well as applications to real- world problems. MARKETS: For practicing engineers and scientists who design and analyze signal processing systems, i.e., to extract information from noisy signals — radar engineer, sonar engineer, geophysicist, oceanographer, biomedical engineer, communications engineer, economist, statistician, physicist, etc.

Purinergic signalling in epithelial ion transport

DEFF Research Database (Denmark)

Novak, Ivana

2011-01-01

, including ion transport. In this review, I will first introduce the main components of the extracellular ATP signalling, which have become known as the purinergic signalling system. With more than 50 components or processes, just at cell membranes, it ranks as one of the most versatile signalling systems......-regulators of secretion. On an organ level, both receptor types can exert physiological functions and together with other partners in the purinergic signalling, integrated models for epithelial secretion and absorption are emerging....

The global thermodynamic arrow of time

Energy Technology Data Exchange (ETDEWEB)

Castagnino, M; Laciana, C [Instituto de Astronomia y Fisica del Espacio, Casilla de Correos 67, Sucursal 28, 1428 Buenos Aires (Argentina)

2002-05-21

It is shown that in a semiclassical model of the universe the out-of-equilibrium (Landau) and phenomenological entropies grow with the 'usual' evolutions a {approx} t{sup {alpha}}, {alpha} < 2, breaking the time symmetry of the evolution equations.

The global thermodynamic arrow of time

International Nuclear Information System (INIS)

Castagnino, M; Laciana, C

2002-01-01

It is shown that in a semiclassical model of the universe the out-of-equilibrium (Landau) and phenomenological entropies grow with the 'usual' evolutions a ∼ t α , α < 2, breaking the time symmetry of the evolution equations

Curare: the South American arrow poison.

Science.gov (United States)

Lee, M R

2005-02-01

The history of curare is both curious and convoluted. A product of South American culture it emerged in the sixteenth century from the mists of antiquity at the same time as quinine, coca, and chocolate. Like quinine, at first came the extract but no plant, and later the plant but no chemical compound. It took more than 300 years and the efforts of many explorers and scientists to resolve the problem. These included Condamine, Humboldt, Brodie, Waterton, Bernard, Dale, Walker, and King. Finally, the pure compound d-tubocurarine was isolated from the liana Chondrodendron and synthesised. Its specific physiological action was blockade of the effect of acetylcholine at the neuro-muscular junction. Such a paralytic poison could be used to kill oneself or others. The bizarre plot to kill the Prime Minister, Lloyd George, during the First World War is described. Fortunately this nefarious plan was thwarted by the Secret Service!