Sample records for arrhythmogenic automaticity induced

  1. Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

    Okada, Jun-ichi; Yoshinaga, Takashi; Kurokawa, Junko; Washio, Takumi; Furukawa, Tetsushi; Sawada, Kohei; Sugiura, Seiryo; Hisada, Toshiaki


    To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required. We introduce a novel screening system for drug-induced arrhythmogenic risk that combines in vitro pharmacological assays and a multiscale heart simulator. For 12 drugs reported to have varying cardiotoxicity risks, dose-inhibition curves were determined for six ion channels using automated patch clamp systems. By manipulating the channel models implemented in a heart simulator consisting of more than 20 million myocyte models, we simulated a standard electrocardiogram (ECG) under various doses of drugs. When the drug concentrations were increased from therapeutic levels, each drug induced a concentration-dependent characteristic type of ventricular arrhythmia, whereas no arrhythmias were observed at any dose with drugs known to be safe. We have shown that our system combining in vitro and in silico technologies can predict drug-induced arrhythmogenic risk reliably and efficiently. PMID:26601174

  2. Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity

    Osadchii, Oleg E; Larsen, Anders Peter; Olesen, Soren Peter


    the predictive value of electrical restitution in hypokalemia-induced arrhythmogenicity. We recorded monophasic APs and measured effective refractory periods (ERP) at distinct ventricular epicardial and endocardial sites and monitored volume-conducted ECG at baseline and after hypokalemic perfusion (2.5 mM K......The ventricular action potential (AP) shortens exponentially upon a progressive reduction of the preceding diastolic interval. Steep electrical restitution slopes have been shown to promote wavebreaks, thus contributing to electrical instability. The present study was designed to assess......(+) for 30 min) in isolated guinea pig heart preparations. The restitution of AP duration measured at 90% repolarization (APD(90)) was assessed after premature extrastimulus application at variable coupling stimulation intervals, and ERP restitution was assessed by measuring refractoriness over a wide range...

  3. Arrhythmogenic Cardiomyopathy.

    Corrado, Domenico; Basso, Cristina; Judge, Daniel P


    Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients and athletes. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricular involvement is often observed. It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and alteration of intracellular signal transduction. The diagnosis of arrhythmogenic cardiomyopathy does not rely on a single gold standard test but is achieved using a scoring system, which encompasses familial and genetic factors, ECG abnormalities, arrhythmias, and structural/functional ventricular alterations. The main goal of treatment is the prevention of sudden cardiac death. Implantable cardioverter defibrillator is the only proven lifesaving therapy; however, it is associated with significant morbidity because of device-related complications and inappropriate implantable cardioverter defibrillator interventions. Selection of patients who are the best candidates for implantable cardioverter defibrillator implantation is one of the most challenging issues in the clinical management. © 2017 American Heart Association, Inc.

  4. Maturation-Based Model of Arrhythmogenic Right Ventricular Dysplasia Using Patient-Specific Induced Pluripotent Stem Cells.

    Wen, Jian-Yan; Wei, Chuan-Yu; Shah, Khooshbu; Wong, Johnson; Wang, Cheng; Chen, Huei-Sheng Vincent


    Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in-vitro modeling of human cardiac disorders for pathogenic and therapeutic investigations. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging because of the uncertainty regarding the ability of relatively immature iPSC-CMs to fully recapitulate adult disease phenotypes. Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by pathological fibrofatty infiltration and cardiomyocyte (CM) loss predominantly in the right ventricle (RV), leading to heart failure and lethal arrhythmias. Over 50% of affected individuals have desmosome gene mutations, most commonly inPKP2encoding plakophilin-2. Using Yamanaka's pluripotent factors, we generated iPSC lines from ARVD patients withPKP2mutations. We first developed a method to induce metabolic maturation of iPSC-CMs and showed that induction of adult-like metabolic energetics from an embryonic/glycolytic state is essential to model an adult-onset cardiac disease using patient-specific iPSCs. Furthermore, we showed that coactivation of normal peroxisome proliferator-activated receptor (PPAR)-α and abnormal PPARγ pathways in ARVD iPSC-CMs resulted in exaggerated CM lipogenesis, CM apoptosis, Na(+)channel downregulation and defective intracellular calcium handling, recapitulating the pathological signatures of ARVD. Using this model, we revealed novel pathogenic insights that metabolic derangement in an adult-like metabolic milieu underlies ARVD pathologies, enabling us to propose novel disease-modifying therapeutic strategies.

  5. Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy

    Benoist, David; Stones, Rachel; Drinkhill, Mark; Bernus, Olivier; White, Ed


    Mechanisms associated with right ventricular (RV) hypertension and arrhythmias are less understood than those in the left ventricle (LV). The aim of our study was to investigate whether and by what mechanisms a proarrhythmic substrate exists in a rat model of RV hypertension and hypertrophy. Rats were injected with monocrotaline (MCT; 60 mg/kg) to induce pulmonary artery hypertension or with saline (CON). Myocardial levels of mRNA for genes expressing ion channels were measured by real-time R...

  6. Genetics Home Reference: arrhythmogenic right ventricular cardiomyopathy

    ... Twitter Home Health Conditions ARVC arrhythmogenic right ventricular cardiomyopathy Printable PDF Open All Close All Enable Javascript ... the expand/collapse boxes. Description Arrhythmogenic right ventricular cardiomyopathy ( ARVC ) is a form of heart disease that ...

  7. Amrinone effects on electromechanical coupling and depolarization-induced automaticity in ventricular muscle of guinea pigs and ferrets.

    Malécot, C O; Arlock, P; Katzung, B G


    The effects of the cardiotonic agent, amrinone (0.05-4 mM), on electrical and mechanical activities of ferret and guinea-pig papillary muscles were studied using current and voltage clamp (single sucrose gap) techniques. In current clamp studies, amrinone increased, in a dose-dependent manner, contractile force elicited by action potential in both species. Depolarization-induced automaticity was facilitated in ferret muscles at all maximum diastolic potentials between -70 and -15 mV. Facilitation of automaticity in guinea-pig muscles occurred only at potentials more negative than -35 mV and was suppressed at more positive potentials. Cimetidine (10 microM) partially reversed the effects of amrinone on automaticity in both species. In voltage clamp studies, amrinone increased the slow inward current. Steady-state outward current was increased in guinea-pig but not in ferret muscles. A dual effect of amrinone on tension was observed. Amrinone was found to increase phasic tension of ferret papillary muscles only for depolarizations lasting less than 250 to 300 msec. For longer depolarizations, amrinone decreased the phasic tension (in a dose-dependent manner), whereas the tonic tension was not modified. The decrease as well as the increase in tension was associated with an increase of the slow inward current. The results suggest that amrinone may be arrhythmogenic and may have an intracellular action at the sarcoplasmic reticulum level (partial inhibition) in addition to its action on the calcium current.

  8. Arrhythmogenic cardiomyopathy : diagnosis, genetic background, and risk management

    Groeneweg, J. A.; van der Heijden, J. F.; Dooijes, D.; van Veen, T. A. B.; van Tintelen, J. P.; Hauer, R. N.


    Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is a hereditary disease characterised by ventricular arrhythmias, right ventricular and/or left ventricular dysfunction, and fibrofatty replacement of cardiomyocytes. Patients with A

  9. Genetic bases of arrhythmogenic right ventricular cardiomyopathy

    Alessandra Rampazzo


    Full Text Available Arrhythmogenic right ventricular cardiomyopathy (ARVC is a heart muscle disease in which the pathological substrate is a fibro-fatty replacement of the right ventricular myocardium. The major clinical features are different types of arrhythmias with a left branch block pattern. ARVC shows autosomal dominant inheritance with incomplete penetrance. Recessive forms were also described, although in association with skin disorders. Ten genetic loci have been discovered so far and mutations were reported in five different genes. ARVD1 was associated with regulatory mutations of transforming growth factor beta-3 (TGFβ3, whereas ARVD2, characterized by effort-induced polymorphic arrhythmias, was associated with mutations in cardiac ryanodine receptor-2 (RYR2. All other mutations identified to date have been detected in genes encoding desmosomal proteins: plakoglobin (JUP which causes Naxos disease (a recessive form of ARVC associated with palmoplantar keratosis and woolly hair; desmoplakin (DSP which causes the autosomal dominant ARVD8 and plakophilin-2 (PKP2 involved in ARVD9. Desmosomes are important cell-to-cell adhesion junctions predominantly found in epidermis and heart; they are believed to couple cytoskeletal elements to plasma membrane in cell-to-cell or cell-to-substrate adhesions.

  10. New test for arrhythmogenic right ventricular cardiomyopathy

    van Tintelen, J. Peter; Hauer, Richard N. W.

    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is challenging to diagnose because of nonspecific findings, particularly in the early phases of the disease. clinical diagnosis is made on the basis of several criteria, but these lack sensitivity. Asimaki et al. suggest that

  11. Arrhythmogenic right ventricular dysplasia: A case report

    Tessa Negrín Valdés


    Full Text Available Arrhythmogenic right ventricular dysplasia is a heart muscle disease that predominantly affects the right ventricle, bringing about the replacement of normal myocardium with fatty or fibrofatty tissue and causing sudden death in young individuals. Ventricular tachycardia is an important clinical manifestation, although there are reports of right or global heart failure. The diagnosis is confirmed by echocardiography and magnetic resonance imaging. The case of a 65-year-old former smoker, with hypertension and ischemic heart disease, a history of effort syncope symptoms and proven non-sustained ventricular tachycardia, with morphology of left bundle branch block, is reported. Relevant diagnostic studies were performed, and echocardiographic elements which were compatible with arrhythmogenic right ventricular dysplasia were found. Therefore, an implantable cardioverter defibrillator was implanted, after which the patient has had a favorable outcome.

  12. Patient's Guide to Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

    ... Page Patient’s Guide to Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Past to Present Crystal Tichnell , Cynthia A. James , ... Info & Metrics eLetters Introduction Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited progressive disease of ...

  13. Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes

    Chen, Y-J; Chen, Y-C; Wongcharoen, W; Lin, C-I; Chen, S-A


    Background and purpose: Pulmonary veins are the most important focus for the generation of atrial fibrillation. Abnormal calcium homeostasis with ryanodine receptor dysfunction may underlie the arrhythmogenic activity in pulmonary veins. The preferential ryanodine receptor stabilizer (K201) possesses antiarrhythmic effects through calcium regulation. The purpose of this study was to investigate the effects of K201 on the arrhythmogenic activity and calcium regulation of pulmonary vein cardiomyocytes. Experimental approach: The ionic currents and intracellular calcium were studied in isolated single cardiomyocytes from rabbit pulmonary vein before and after the administration of K201, by the whole-cell patch clamp and indo-1 fluorimetric ratio techniques. Key results: K201 (0.1, 0.3, 1 μM) reduced the firing rates in pulmonary vein cardiomyocytes, decreased the amplitudes of the delayed afterdepolarizations and prolonged the action potential duration. K201 decreased the L-type calcium currents, Na+/Ca2+ exchanger currents, transient inward currents and calcium transients. K201 (1 μM, but not 0.1 μM or 0.3 μM) also reduced the sarcoplasmic reticulum calcium content. Moreover, both the pretreatment and administration of K201 (0.3 μM) decreased the isoprenaline (10 nM)-induced arrhythmogenesis in pulmonary veins. Conclusions and implications: K201 reduced the arrhythmogenic activity of pulmonary vein cardiomyocytes and attenuated the arrhythmogenicity induced by isoprenaline. These findings may reveal the anti-arrhythmic potential of K201. PMID:17994112

  14. Molecular genetics of arrhythmogenic right ventricular cardiomyopathy : emerging horizon?

    van Tintelen, J. Peter; Hofstra, Robert M. W.; Wiesfeld, Ans C. P.; van den Berg, Maarten P.; Hauer, Richard N. W.; Jongbloed, Jan D. H.

    Purpose of review Recent developments in the elucidation of genes underlying arrhythmogenic right ventricular cardiomyopathy and possible pathogenic mechanisms will be highlighted. Recent findings The cardiac desmosome is a multiprotein structure involved in cell-cell interactions. Mutations in

  15. New ECG Criteria in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

    M.G.P.J. Cox; J.J. van der Smagt; A.A.M. Wilde; A.C.P. Wiesfeld; D.E. Atsma; M.R. Nelen; L.M. Rodriguez; P. Loh; M.J. Cramer; P.A. Doevendans; J.P. van Tintelen; J.M.T. de Bakker; R.N.W. Hauer


    Background-Desmosomal changes, electric uncoupling, and surviving myocardial bundles in fibrofatty tissue characterize arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Resultant activation delay is pivotal for reentry and thereby ventricular tachycardia (VT). Current task force cr

  16. Dynamic electrocardiographic changes in patients with arrhythmogenic right ventricular cardiomyopathy.

    Quarta, Giovanni


    Electrocardiographic (ECG) abnormalities of depolarisation and repolarisation contribute to the diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC). The development of diagnostic ECG features were investigated in a genotyped cohort with ARVC to provide more sensitive markers of early disease.

  17. Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy.

    Roberts, Jason D; Veinot, John P; Rutberg, Julie; Gollob, Michael H


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) represents an inherited cardiomyopathy that manifests clinically with malignant ventricular arrhythmias, sudden cardiac death, and less commonly heart failure. The condition is characterized by replacement of the myocardium, primarily of the right ventricle, with fibrofatty tissue. Extensive fibrofatty replacement of the myocardium has been previously thought to be pathognomonic of ARVC; however, this report details two other forms of inherited cardiomyopathy, namely hypertrophic cardiomyopathy (HCM) and the PRKAG2 cardiac syndrome, that were found to have significant fibrofatty myocardial replacement at pathologic examination. This report represents the first documentation of inherited cardiomyopathies mimicking ARVC and highlights the concept that other cardiac conditions can be associated with fibrofatty replacement of the myocardium. Copyright 2010 Elsevier Inc. All rights reserved.

  18. Arrhythmogenic channelopathy syndromes presenting as refractory epilepsy.

    Hazle, Matthew A; Shellhaas, Renée A; Bradley, David J; Dick, Macdonald; Lapage, Martin J


    Children and young adults with potentially lethal cardiac channelopathies often present to medical care with a history of syncope or seizures due to episodic ventricular arrhythmias and associated cerebral hypoperfusion. Two important types of genetic arrhythmia syndromes-long QT syndrome and catecholaminergic polymorphic ventricular tachycardia-are discussed using relevant case examples. The pathophysiology and distinguishing clinical features of these conditions are reviewed. The patients in each case were ultimately diagnosed with a cardiac channelopathy as the cause for their syncope and refractory seizures. With appropriate medical management, no further events have occurred to date. Cardiac channelopathies can be misdiagnosed as refractory epilepsy when in fact these events represent convulsive syncopes. Knowledge of and suspicion for these arrhythmogenic conditions may expedite diagnosis and improve outcomes. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. [Automatic assay of circulating immune complexes induced by oral contraceptives (author's transl)].

    Buxtorf, J C; Lemort, N


    The authors describe an automatic method to assay circulating immune complexes induced by OC (oral contraception). The method is simple, quick, and cheap; it consists of detecting the immune complexes precipitating by ammonium sulphate at 25% saturation, as in the manual method. In the automatic method the procedure is done on an Auto Analyzer apparatus, which allows direct reading of the floculation, and does not require washing of the precipitate. Results obtained for 164 sera tested automatically were compared with results obtained by the manual method; the correlation was very significant. The same method can be used for screening other immune complexes.

  20. A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report.

    Ponsiglione, Andrea; Puglia, Marta; Morisco, Carmine; Barbuto, Luigi; Rapacciuolo, Antonio; Santoro, Mario; Spinelli, Letizia; Trimarco, Bruno; Cuocolo, Alberto; Imbriaco, Massimo


    Arrhythmogenic right ventricular dysplasia (ARVD), is a genetic disorder of the heart, which mainly involves the right ventricle. It is characterized by hypokinetic areas at the free wall of the right ventricle (RV) or both ventricles, where myocardium is replaced by fibrous or fatty tissue. ARVD is an important cause of ventricular arrhythmias in children and young adults. Although the transmission of the disease is based on hereditary, in young adults it may not show any symptoms. The main differential diagnoses with other frequent etiological causes of sudden arrhythmia are: idiopathic outflow tract ventricular tachycardia of the RV, myocarditis, dilated cardiomyopathy and sarcoidosis. We describe an unusual case of a 44-year-old woman who was hospitalized for ventricular tachycardia, deep asthenia and dyspnoea with no previous history of cardiac disease. The patient had a ten-year history of palpitations, which started immediately after her last pregnancy. She was diagnosed with both acute/subacute viral myocarditis and arrhythmogenic right ventricular dysplasia, based on established clinical and cardiac MRI criteria. After the diagnosis the patient received an automatic implantable cardioverter defibrillator. Currently, she is on clinical follow-up with no apparent further complications. Analyzing this rare case, we have shown the link between myocarditis and arrhythmogenic right ventricular dysplasia, and how important is to perform a cardiac MRI, in the context of acute myocarditis and ventricular arrhythmia.

  1. Arrhythmogenic Right Ventricular Dysplasia in Neuromuscular Disorders

    Finsterer, Josef; Stöllberger, Claudia


    OBJECTIVES Arrhythmogenic right ventricular dysplasia (ARVD) is a rare, genetic disorder predominantly affecting the right ventricle. There is increasing evidence that in some cases, ARVD is due to mutations in genes, which have also been implicated in primary myopathies. This review gives an overview about myopathy-associated ARVD and how these patients can be managed. METHODS A literature review was done using appropriate search terms. RESULTS The myopathy, which is most frequently associated with ARVD, is the myofibrillar myopathy due to desmin mutations. Only in a single patient, ARVD was described in myotonic dystrophy type 1. However, there are a number of genes causing either myopathy or ARVD. These genes include lamin A/C, ZASP/cypher, transmembrane protein-43, titin, and the ryanodine receptor-2 gene. Diagnosis and treatment are identical for myopathy-associated ARVD and nonmyopathy-associated ARVD. CONCLUSIONS Patients with primary myopathy due to mutations in the desmin, dystrophia myotonica protein kinase, lamin A/C, ZASP/cypher, transmembrane protein-43, titin, or the ryanodine receptor-2 gene should be screened for ARVD. Patients carrying a pathogenic variant in any of these genes should undergo annual cardiological investigations for cardiac function and arrhythmias. PMID:27790050

  2. Nitroprusside modulates pulmonary vein arrhythmogenic activity

    Chen Yao-Chang


    Full Text Available Abstract Background Pulmonary veins (PVs are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation. Elimination of nitric oxide (NO enhances cardiac triggered activity, and NO can decrease PV arrhythmogensis through mechano-electrical feedback. However, it is not clear whether NO may have direct electrophysiological effects on PV cardiomyocytes. This study is aimed to study the effects of nitroprusside (NO donor, on the ionic currents and arrhythmogenic activity of single cardiomyocytes from the PVs. Methods Single PV cardiomyocytes were isolated from the canine PVs. The action potential and ionic currents were investigated in isolated single canine PV cardiomyocytes before and after sodium nitroprusside (80 μM, using the whole-cell patch clamp technique. Results Nitroprusside decreased PV cardiomyocytes spontaneous beating rates from 1.7 ± 0.3 Hz to 0.5 ± 0.4 Hz in 9 cells (P Conclusion Nitroprusside regulates the electrical activity of PV cardiomyocytes, which suggests that NO may play a role in PV arrhythmogenesis.

  3. Cardiotoxic and Arrhythmogenic Effects of Hemiscorpius lepturus Scorpion Venom in Rats

    Khalil Pourkhalili


    Full Text Available Background: Envenomation by Hemiscorpius lepturus is not painful and the clinical manifestations include bloody urine due to hemoglobinuria or hematuria, dermonecrotic reactions,cardiac arrhythmia and in minority of cases acute renal failure which may lead to death following disseminated intravascular coagulation in infants. Cardiac effects of envenomation by H. lepturus venom including inotropic, chronotropic and arrhythmogenic properties are not studied as now in rat hearts with Langendorff apparatus.Methods: Rat hearts were allowed to equilibrate in its buffer and cardiotropic plus arrhythmogenic effects induced by injection of different doses of H. lepturus venom were detected and recorded by computer acquisition based data in Langendorff apparatus. The neutralizing effects of Razi Institute antivenom and autonomic drugs were assayed in parallel studies.Results: Hemiscorpius lepturus venom (25 μg/100 l treatment caused a negative inotropic (65.4 ± 3.2 versus 110.2 ± 3.4 and chronotropic effects (186.3 ± 4.2 versus 302 ± 6.3 in comparison to normal saline. Arrhythmogenic aspects including bradycardia, QRS widening and ST depression were induced by venom injection. Pre venom treatment (20 min of Razi Institute antivenom (10 μl neutralized cardiotropic effects but post venom injection (15 min later had no therapeutic role. Pre (10 min before and post (15 min after injection of adrenaline (10 μl neneutralized cardiotropic effects while pre venom injection (20 min of propanolol (10 μl had aggravating effects.Conclusion: Our study paves the way for further in vivo investigation of cardiovascular effects of this venom for finding suitable treatments instead of its ordinary antivenom medication in cardiogenic shock induced by the venom.

  4. Arrhythmogenic right ventricular dysplasia: MRI findings

    Wall, E.E. van der; Bootsma, M.M.; Schalij, M.J. [Dept. of Cardiology, Leiden Univ. Medical Center, Leiden (Netherlands); Kayser, H.W.M.; Roos, A. de [Dept. of Radiology, Leiden Univ. Medical Center, Leiden (Netherlands)


    Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder of unknown cause that is characterized pathologically by fibrofatty replacement of the right ventricular myocardium. Clinical manifestations include structural and functional malformations of the right ventricle, electrocardiographic abnormalities, and presentation with ventricular tachycardias with left bundle branch pattern or sudden death. The disease is often familial with an autosomal inheritance. In addition to right ventricular dilatation, right ventricular aneurysms are typical deformities of ARVD and they are distributed in the so-called ''triangle of dysplasia'', i. e., right ventricular outflow tract, apex, and infundibulum. Ventricular aneurysms at these sites can be considered pathognomonic of ARVD. Another typical hallmark of ARVD is fibrofatty infiltration of the right ventricular free wall. These functional and morphologic characteristics are relevant to clinical imaging investigations such as contrast angiography, echocardiography, radionuclide angiography, ultrafast computed tomography, and magnetic resonance imaging (MRI). Among these techniques, MRI allows the clearest visualization of the heart, in particular because the right ventricle is involved, which is usually more difficult to explore with the other imaging modalities. Furthermore, MRI offers the specific advantage of visualizing adipose infiltration as a bright signal of the right ventricular myocardium. MRI provides the most important anatomic, functional, and morphologic criteria for diagnosis of ARVD within one single study. As a result, MRI appears to be the optimal imaging technique for detecting and following patients with clinical suspicion of ARVD. (orig.) [German] Die arrhythmogene rechtsventrikulaere Dysplasie (ARVD), eine Herzmuskelerkrankung unklarer Aetiologie, ist pathologisch durch fettige Degeneration des rechtsventrikulaeren Myokards gekennzeichnet. Die klinischen Symptome

  5. Arrhythmogenic cardiomyopathy in a patient with Noonan syndrome.

    Altamirano, Eugenia; Drut, Ricardo


    Arrhythmogenic ventricular cardiomyopathy (AVC) presents with fat replacement of the myocardium, most commonly of the right ventricle, and ventricular arrhythmias. We report an 11-year-old boy with Noonan syndrome, ventricular arrhythmias, and an ultrasound depicting hypertrophy of the ventricular septum with subaortic stenosis. A surgical resection of the left side of the ventricular septum revealed a thick fibroelastotic endocardium covering a broad band of mature adipose tissue focally containing myocardial cells, fibrosis and chronic inflammatory infiltrates. The two layers covered a band of hypertrophic myocardiocytes with mild interstitial fibrosis. Arrhythmogenic ventricular cardiomyopathy has not been previously reported in the Noonan syndrome.

  6. Cardiac MR imaging in arrhythmogenic heart diseases; Kardiale MRT in der Diagnostik arrhythmogener Herzerkrankungen

    Boehm, C.K.; Dinter, D.J.; Diehl, S.J.; Neff, K.W. [Universitaetsklinikum Mannheim, Institut fuer Klinische Radiologie, Mannheim (Germany); Papavassiliu, T.; Borggrefe, M. [Universitaetsklinikum Mannheim, Medizinische Klinik, Mannheim (Germany)


    Cardiac arrhythmias are assessed with a combination of history, clinical examination, electrocardiogram, Holter monitor, if necessary supplemented by invasive cardiac electrophysiology. In ischemic heart disease (IHD) coronary angiography is performed in addition. Echocardiography is usually the primary imaging modality. MRI is increasingly recognized as an important investigation allowing more accurate cardiac morphological and functional assessment. Approximately one-fifth of deaths in Western countries are due to sudden cardiac death, 80% of which are caused by arrhythmias. Typical causes range from diseases with high prevalence (IHD in men 30%) to myocarditis (prevalence 1-9%) and rare cardiomyopathies (prevalence HCM 0.2%, ARVC 0.02%, Brugada syndrome approx. 0.5%). The characteristic MRI features of arrhythmogenic diseases and the new aspects of characteristic distribution of late enhancement allow etiologic classification and differential diagnosis. MRI represents an important tool for detection of the underlying cause and for risk stratification in many diseases associated with arrhythmias. (orig.) [German] Herzrhythmusstoerungen werden durch die Zusammenschau von Anamnese, klinischer Untersuchung, Elektrokardiogramm, Langzeit-EKG sowie ggf. einer invasiven elektrophysiologischen Untersuchung beurteilt. Bei der koronaren Herzerkrankung (KHK) erfolgt zusaetzlich eine Koronarangiographie. Die Echokardiographie stellt das primaere bildgebende Verfahren dar. Die MRT des Herzens ermoeglicht eine genauere morphologische und funktionelle Darstellung des Herzens und gewinnt damit zunehmend an Bedeutung. Etwa jeder 5. Todesfall in westlichen Industriestaaten ist auf einen ploetzlichen Herztod zurueckzufuehren, davon sind ca. 80% durch Herzrhythmusstoerungen verursacht. Typische Ursachen reichen von Krankheiten mit hoher Praevalenz (KHK bei Maennern 30%) ueber Myokarditiden (Praevalenz 1-9%) bis zu selteneren Kardiomyopathien (Praevalenz HCM 0,2%, ARVC 0,02%, Brugada

  7. Late presentation of arrhythmogenic right ventricular cardiomyopathy: a case report

    Papaioannou Georgios I


    Full Text Available Abstract Introduction Arrhythmogenic right ventricular cardiomyopathy is an inherited myocardial disease affecting predominantly young people and manifests as sustained ventricular tachycardia with left bundle branch block morphology, sudden death or isolated right or biventricular heart failure. However, its first manifestation as sustained ventricular tachycardia in older patients without preceding symptoms of heart failure is infrequent. To our knowledge, our patient is among the oldest reported in the literature presenting with ventricular tachycardia because of arrhythmogenic right ventricular cardiomyopathy without preceding symptoms of heart failure. Case presentation We present an unusual case of a very late presentation of a right ventricular cardiomyopathy in a 72-year-old white Caucasian man. The patient was admitted with symptoms of weakness, dizziness and chest discomfort for several hours. His electrocardiogram showed a wide-complex tachycardia with left bundle branch block morphology and left axis deviation. Because of continuing hemodynamic instability, the patient was cardioverted to sinus rhythm with a single 300 J shock. His post-cardioversion electrocardiogram, cardiac echocardiogram, coronary angiogram, magnetic resonance imaging and electrophysiological study confirmed the diagnosis of arrhythmogenic right ventricular cardiomyopathy. The patient was treated with an implantable cardioverter defibrillator and discharged on sotalol. Conclusion This case report demonstrates that arrhythmogenic right ventricular cardiomyopathy may have a very late presentation and this diagnosis should be considered as a potential cause of sustained ventricular tachycardia of right ventricular origin among the elderly and should be treated accordingly.

  8. Bradyarrhythmias: first presentation of arrhythmogenic right ventricular cardiomyopathy?

    Burghouwt, Danielle E; Kammeraad, Janneke Ae; Knops, Paul; du Plessis, Frederik A; de Groot, Natasja Ms


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder characterized by progressive replacement of myocardial cells by fibro-fatty tissue giving rise to ventricular tachyarrhythmias. In this case report, we describe a pediatric patient with sinoatrial arrests and second degree atrioventricular conduction block several years before ARVC became apparent. These findings suggest that bradyarrhythmias can also be the first expression of ARVC.

  9. QT dispersion in patients with arrhythmogenic right ventricular dysplasia

    Benn, Marianne; Hansen, P S; Pedersen, A K


    , of electrical instability. The present study was conducted to assess the occurrence of QT dispersion and its modulation during treatment with sotalol. Methods Twenty-five patients with the diagnosis of arrhythmogenic right ventricular dysplasia were studied retrospectively. Fourteen patients were considered low...

  10. Arrhythmogenic right ventricular cardiomyopathy/dysplasia

    Basso Cristina


    Full Text Available Abstract Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D is a heart muscle disease clinically characterized by life-threatening ventricular arrhythmias. Its prevalence has been estimated to vary from 1:2,500 to 1:5,000. ARVC/D is a major cause of sudden death in the young and athletes. The pathology consists of a genetically determined dystrophy of the right ventricular myocardium with fibro-fatty replacement to such an extent that it leads to right ventricular aneurysms. The clinical picture may include: a subclinical phase without symptoms and with ventricular fibrillation being the first presentation; an electrical disorder with palpitations and syncope, due to tachyarrhythmias of right ventricular origin; right ventricular or biventricular pump failure, so severe as to require transplantation. The causative genes encode proteins of mechanical cell junctions (plakoglobin, plakophilin, desmoglein, desmocollin, desmoplakin and account for intercalated disk remodeling. Familiar occurrence with an autosomal dominant pattern of inheritance and variable penetrance has been proven. Recessive variants associated with palmoplantar keratoderma and woolly hair have been also reported. Clinical diagnosis may be achieved by demonstrating functional and structural alterations of the right ventricle, depolarization and repolarization abnormalities, arrhythmias with the left bundle branch block morphology and fibro-fatty replacement through endomyocardial biopsy. Two dimensional echo, angiography and magnetic resonance are the imaging tools for visualizing structural-functional abnormalities. Electroanatomic mapping is able to detect areas of low voltage corresponding to myocardial atrophy with fibro-fatty replacement. The main differential diagnoses are idiopathic right ventricular outflow tract tachycardia, myocarditis, dialted cardiomyopathy and sarcoidosis. Only palliative therapy is available and consists of antiarrhythmic drugs

  11. Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy

    Paul, Matthias [University Hospital Muenster, Department of Cardiology and Angiology, Muenster (Germany); University Hospital Muenster, Institute for Genetics of Heart Diseases, Muenster (Germany); Rahbar, Kambiz; Kies, Peter; Schober, Otmar [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Gerss, Joachim [University of Muenster, Institute of Biostatistics and Clinical Research, Muenster (Germany); Schaefers, Klaus; Schaefers, Michael [University of Muenster, European Institute for Molecular Imaging - EIMI, Muenster (Germany); Breithardt, Guenter [University Hospital Muenster, Department of Cardiology and Angiology, Muenster (Germany); Schulze-Bahr, Eric [University Hospital Muenster, Institute for Genetics of Heart Diseases, Muenster (Germany); Wichter, Thomas [Marienhospital Osnabrueck, Department of Cardiology, Niels-Stensen-Kliniken, Osnabrueck (Germany)


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascular resistance in patients with nonfailing ARVC using H{sub 2}{sup 15} O and PET. In ten male patients with ARVC (mean age 49 {+-} 14 years), MBF was quantified at rest and during adenosine-induced hyperaemia using H{sub 2}{sup 15} O PET. Results were compared with those obtained in 20 age-matched healthy male control subjects (mean age 46 {+-} 14 years). Resting MBF was not significantly different between patients with ARVC and controls (MBF{sub rest} 1.19 {+-} 0.29 vs. 1.12 {+-} 0.20 ml/min/ml). However, hyperaemic MBF was significantly lower in patients with ARVC than in controls (2.60 {+-} 0.96 vs. 3.68 {+-} 0.84 ml/min/ml; p = 0.005). Consequently, patients with ARVC had a significantly lower coronary flow reserve than control subjects (2.41 {+-} 1.34 vs. 3.39 {+-} 0.93; p = 0.030). In addition, hyperaemic coronary vascular resistance was increased in patients with ARVC (36.79 {+-} 12.91 vs. 26.31 {+-} 6.49 mmHg x ml{sup -1} x min x ml; p = 0.007), but was found to be unchanged at rest. In this small well-characterized cohort of patients with nonfailing ARVC, we found a significantly reduced hyperaemic MBF and increased coronary vascular resistance. Further studies are necessary to corroborate this potential new functional aspect of the pathophysiological mechanisms underlying ARVC. (orig.)

  12. Science and practice of arrhythmogenic cardiomyopathy: A paradigm shift

    Mohamed ElMaghawry


    Full Text Available The clinical, genetic, and molecular paradigm of arrhythmogenic right ventricular cardiomyopathy (ARVC has markedly progressed through the last three decades, shifting from the classical ARVC as a progressive condition characterized by fibrofatty replacement of the right ventricle,2,3,4 into a wider spectrum of arrhythmogenic cardiomyopathy (AC,5 which covers ARVC with its various clinical phases (occult, electric, right heart failure and late stage biventricular heart failure, biventricular arrhythmic cardiomyopathy, left dominant arrhythmic cardiomyopathy, Naxos and Carvajal syndromes. Epidemiologically, the disease was first associated with the Mediterranean basin (mainly Italy and France, however further studies have reported AC in many races and ethnic backgrounds6,7,8. Moreover, with regard to the pathoitiology of the disease, dysplasia was originally assumed as the disease mechanism. Other mechanisms were later postulated, such as inflammation and transdifferentiation. However, more recent animal models have established that dystrophy, either by myocyte necrosis or apoptosis, is the founding pathological process of AC.

  13. MR demonstration of septal involvement in arrhythmogenic right ventricular dysplasia

    Malhaire, Caroline; Rahmouni, Alain [Centre Hospitalo-Universitaire Henri Mondor, Service de Radiologie et d' Imagerie Medicale, Creteil Cedex (France); Garot, Jerome [Centre Hospitalo-Universitaire Henri Mondor, Service de Cardiologie, Creteil Cedex (France)


    Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disease of unknown origin. Although MR imaging is regarded as the best technique for the demonstration of functional and structural abnormalities in ARVD, fat deposits in the interventricular septum have never been documented on MR imaging. We report the case of interventricular septal fatty deposition demonstrated by fat-suppressed MR imaging in a 48-year-old man. (orig.)

  14. Clinical and familial study of arrhythmogenic right ventricular cardiomyopathy

    单其俊; 曹克将; 黄元铸; 廖铭扬; 陈明龙; 李闻奇; 邹建刚; 朱必顺; 马文珠


    Objective To explore the characteristics of arrhythmogenic rightventricular cardiomyopathy (ARVC). Methods Seven patients with arrhythmogenic right ventricular cardiomyopathy and 34 members of three families were studied. All patients and family members underwent history collection, clinical examination, electrocardiogram (ECG), two-dimensional echocardiography (2-DE) and a signal averaging electrocardiogram. Programmed ventricular stimulation was performed in five patients. Results All patients and family members had normal morphologic characteristics and normal function of the left ventricular by 2-DE. Fourteen persons had abnormal findings indicating ARVC. Five had enlargement of the right ventricular with diffused hypocontractility, eight had thin and systolic bulging in the focal anterior wall with hypokinesia and one had bulging of the inferior wall. Twenty-five persons (seven patients and 18 family members) had abnormal findings in ECG. Positive ventricular late potential was recorded in 13 persons (six patients). Two to three monomorphic ventricular tachycardia (VT) with left bundle branch block (LBBB) configurations were induced in five patients. Ventricular fibrillation was induced in two patients during the electrophysiologic study (EPS). Five patients had very high pacing threshold and/or ineffective pacing in one or many regions of the right ventricle. Two members of one family died suddenly. One member was a dwarf with ARVC. Spontaneous VT with a left bundle branch block (LBBB) configuration was recorded in five patients, polymorphic VT with extremely short coupling interval in one, and premature ventricular complexes with LBBB configuration in 12 (six patients). Conclusion Our familial study strongly suggests that ARVC may be a hereditary disease and it is helpful in the diagnosis and detection of ARVC. The most common manifestations were abnormal structure and function of the right ventricle and abnormal ECG of repolarization and ventricular

  15. Automatic removal of manually induced artefacts in ultrasound images of thyroid gland.

    Narayan, Nikhil S; Marziliano, Pina; Hobbs, Christopher G L


    Manually induced artefacts, like caliper marks and anatomical labels, render an ultrasound (US) image incapable of being subjected to further processes of Computer Aided Diagnosis (CAD). In this paper, we propose a technique to remove these artefacts and restore the image as accurately as possible. The technique finds application as a pre-processing step when developing unsupervised segmentation algorithms for US images that deal with automatic estimation of the number of segments and clustering. The novelty of the algorithm lies in the image processing pipeline chosen to automatically identify the artefacts and is developed based on the histogram properties of the artefacts. The algorithm was able to successfully restore the images to a high quality when it was executed on a dataset of 18 US images of the thyroid gland on which the artefacts were induced manually by a doctor. Further experiments on an additional dataset of 10 unmarked US images of the thyroid gland on which the artefacts were simulated using Matlab showed that the restored images were again of high quality with a PSNR > 38 dB and free of any manually induced artefacts.

  16. Ventricular tachycardia ablation in arrhythmogenic right ventricular cardiomyopathy patients with TMEM43 gene mutations.

    Abdelwahab, Amir; Gardner, Martin; Parkash, Ratika; Gray, Christopher; Sapp, John


    Catheter ablation of VT in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is often challenging, frequently requiring multiple or epicardial ablation procedures; TMEM43 gene mutations typically cause aggressive disease. We sought to compare VT ablation outcomes for ARVC patients with and without TMEM43 mutations. Patients with prior ablation for ARVC-related VT were reviewed. Demographic, procedural and follow-up data were reviewed retrospectively. Patients with confirmed TMEM43 gene mutations were compared to those with other known mutations or who had no known mutations. Thirteen patients (10 male, mean age 49±14 yrs) underwent 29 ablation procedures (Median 2 procedures/patient, range 1-6) with a median of 4 targeted VTs/patient (range 1 -9). They were followed for a mean duration of 7.3±4.2 years. Gene mutations included TMEM43 (n = 5), PKP2 (n = 2), DSG2 (n = 2), unidentifiable (n = 4). TMEM patients showed more biventricular involvement compared to Non-TMEM patients (80% vs. 12.5%, p = 0.032), more inducible VTs during their ablation procedures (mean VTs/patient: 5.8±3 vs. 2.6±1, p = 0.021). Acute and long-term procedural outcomes did not show a significant difference between the two groups, however TMEM patients had worse composite endpoint of death or transplantation (60% vs. 0, p = 0.035; Log-Rank p = 0.013). TMEM43 mutation patients were more likely to have biventricular arrhythmogenic substrate and more inducible VTs at EP study. Despite comparable acute VT ablation outcomes, long-term prognosis is unfavorable. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  17. Arrhythmogenic right ventricular dysplasia masquerading as an abdominal episode.

    Kaya, Mehmet Gungor; Yalcin, Ridvan; Ozin, Bulent; Altunkan, Sekip; Cengel, Atiye


    A 19-year-old woman presented with abdominal pain. Aside from epigastric tenderness, the patient's physical examination was unremarkable. She developed ventricular tachycardia with left bundle branch block morphology shortly after admission. Echocardiography revealed a thin, enlarged, and hypokinetic right ventricle. Electron beam computed tomography demonstrated hypodense areas in the right ventricular free wall suggestive of fatty infiltration, which suggested arrhythmogenic right ventricular dysplasia. The diagnosis was confirmed with the use of cardiac magnetic resonance imaging. The patient received an implantable cardioverter-defibrillator. This case illustrates a noncardiac presentation of a rare yet treatable cardiac condition.

  18. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: an updated imaging approach.

    Zimmerman, Stefan L


    Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare inherited cardiomyopathy characterized by fibrofatty replacement of the right ventricular myocardium and risk of sudden death from ventricular tachyarrhythmias. Cardiac magnetic resonance (MR) imaging plays an important role in the diagnostic evaluation of patients and family members suspected of having ARVC/D. This article discusses the epidemiology and pathophysiology of ARVC/D, reviews typical MR imaging findings and diagnostic criteria, and summarizes potential pitfalls in the MR imaging evaluation of patients suspected of having ARVC/D.

  19. Effects of extracellular calcium and sodium on depolarization-induced automaticity in guinea pig papillary muscle.

    Katzung, B G


    Regenerative discharge of action potentials is induced in mammalian papillary muscles by passage of small depolarizing currents. In this paper, the effects of various extracellular calcium and sodium concentrations and of tetrodotoxin on this phenomenon were studied in guinea pig papillary muscles in a sucrose gap chamber. Phase 4 diastolic depolarization was found to be associated with an increase in membrane resistance. The slope of phase 4 depolarization was decreased by reductions in extracellular calcium or sodium concentration. The range of maximum diastolic potentials and the thresholds from which regenerative potentials arose were reduced, especially at the positive limit of potentials, by a reduction in either ion. It was concluded that both calcium and sodium influence diastolic depolarization and participate in the regenerative action potentials of depolarization-induced ventricular automaticity.

  20. [Arrhythmogenic right ventricular cardiomyopathy. Case report and a brief literature review].

    Izurieta, Carlos; Curotto-Grasiosi, Jorge; Rocchinotti, Mónica; Torres, María J; Moranchel, Manuel; Cañas, Sebastián; Cardús, Marta E; Alasia, Diego; Cordero, Diego J; Angel, Adriana


    A 51-year-old man was admitted to this hospital because of palpitations and a feeling of dizziness for a period of 2h. The electrocardiogram revealed a regular wide-QRS complex tachycardia at a rate of 250 beats per minute, with superior axis and left bundle branch block morphology without hemodynamically decompensation, the patient was cardioverted to sinus rhythm after the administration of a loading and maintenance dose of amiodarone. The elechtrophysiological study showed the ventricular origin of the arrhythmia. In order to diagnose the etiology of the ventricular tachycardia we performed a coronary arteriography that showed normal epicardial vessels, thus ruling out coronary disease. Doppler echocardiography revealed systolic and diastolic functions of both left and right ventricles within normal parameters, and normal diameters as well. A cardiac magnetic resonance with late enhancement was done, showing structural abnormalities of the right ventricle wall with moderate impairment of the ejection fraction, and a mild dysfunction of the left ventricle. The diagnosis of arrhythmogenic right ventricular cardiomyopathy was performed as 2 major Task Force criteria were met. We implanted an automatic cardioverter defibrillator as a prophylactic measure. The patient was discharged without complications. Copyright © 2012 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved.

  1. Usefulness of immunostaining for plakoglobin as a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy

    Munkholm, Julie; Christensen, Alex H; Svendsen, Jesper H;


    The clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) is often challenging due to phenotypic variation, reduced/age-related penetrance, and lack of a diagnostic test. A single report has suggested quantitative myocardial immunoanalysis for the desmosomal protein...

  2. Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy

    Mast, TP; Teske, Arco J; Walmsley, John; van der Heijden, Jeroen F; van Es, René; Prinzen, Frits W; Delhaas, Tammo; van Veen, Toon A; Loh, KP; Doevendans, Pieter A; Cramer, Maarten J; Lumens, Joost


    BACKGROUND: Previous studies suggested that electrical abnormalities precede overt structural disease in arrhythmogenic right ventricular cardiomyopathy (ARVC). Abnormal RV deformation has been reported in early ARVC without structural abnormalities. The pathophysiological mechanisms underlying thes

  3. Screening for, and management of, possible arrhythmogenic syndromes (channelopathies/ion channel diseases)

    Svendsen, Jesper Hastrup; Geelen, Peter


    This survey assesses the current management strategies for individuals with electrocardiographic features, suggesting an arrhythmogenic syndrome [including long QT syndrome (LQTS), Brugada syndrome (BS), catecholaminergic polymorphic ventricular tachycardia (CPVT) or short QT syndrome] or family ...

  4. Management of patients with Arrhythmogenic Right Ventricular Cardiomyopathy in the Nordic countries

    Haugaa, Kristina H; Bundgaard, Henning; Edvardsen, Thor


    OBJECTIVES: Diagnostics of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) are complex, and based on the 2010 Task Force document including different diagnostic modalities. However, recommendations for clinical management and follow-up of patients with ARVC and their relatives...

  5. A Genetic Variants Database for Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

    van der Zwaag, Paul A.; Jongbloed, Jan D. H.; van den Berg, Maarten P.; van der Smagt, Jasper J.; Jongbloed, Roselie; Bikker, Hennie; Hofstra, Robert M. W.; van Tintelen, J. Peter


    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a hereditary cardiomyopathy characterized by fibrofatty replacement of cardiomyocytes, ventricular tachyarrhythmias and sudden death. ARVD/C is mainly caused by mutations in genes encoding desmosomal proteins. However, the pathoge

  6. Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy.

    Forleo, Cinzia; Carmosino, Monica; Resta, Nicoletta; Rampazzo, Alessandra; Valecce, Rosanna; Sorrentino, Sandro; Iacoviello, Massimo; Pisani, Francesco; Procino, Giuseppe; Gerbino, Andrea; Scardapane, Arnaldo; Simone, Cristiano; Calore, Martina; Torretta, Silvia; Svelto, Maria; Favale, Stefano


    Mutations in the lamin A/C gene (LMNA) were associated with dilated cardiomyopathy (DCM) and, recently, were related to severe forms of arrhythmogenic right ventricular cardiomyopathy (ARVC). Both genetic and phenotypic overlap between DCM and ARVC was observed; molecular pathomechanisms leading to the cardiac phenotypes caused by LMNA mutations are not yet fully elucidated. This study involved a large Italian family, spanning 4 generations, with arrhythmogenic cardiomyopathy of different phenotypes, including ARVC, DCM, system conduction defects, ventricular arrhythmias, and sudden cardiac death. Mutation screening of LMNA and ARVC-related genes PKP2, DSP, DSG2, DSC2, JUP, and CTNNA3 was performed. We identified a novel heterozygous mutation (c.418_438dup) in LMNA gene exon 2, occurring in a highly conserved protein domain across several species. This newly identified variant was not found in 250 ethnically-matched control subjects. Genotype-phenotype correlation studies suggested a co-segregation of the LMNA mutation with the disease phenotype and an incomplete and age-related penetrance. Based on clinical, pedigree, and molecular genetic data, this mutation was considered likely disease-causing. To clarify its potential pathophysiologic impact, functional characterization of this LMNA mutant was performed in cultured cardiomyocytes expressing EGFP-tagged wild-type and mutated LMNA constructs, and indicated an increased nuclear envelope fragility, leading to stress-induced apoptosis as the main pathogenetic mechanism. This study further expands the role of the LMNA gene in the pathogenesis of cardiac laminopathies, suggesting that LMNA should be included in mutation screening of patients with suspected arrhythmogenic cardiomyopathy, particularly when they have ECG evidence for conduction defects. The combination of clinical, genetic, and functional data contribute insights into the pathogenesis of this form of life-threatening arrhythmogenic cardiac laminopathy.

  7. Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy.

    Cinzia Forleo

    Full Text Available Mutations in the lamin A/C gene (LMNA were associated with dilated cardiomyopathy (DCM and, recently, were related to severe forms of arrhythmogenic right ventricular cardiomyopathy (ARVC. Both genetic and phenotypic overlap between DCM and ARVC was observed; molecular pathomechanisms leading to the cardiac phenotypes caused by LMNA mutations are not yet fully elucidated. This study involved a large Italian family, spanning 4 generations, with arrhythmogenic cardiomyopathy of different phenotypes, including ARVC, DCM, system conduction defects, ventricular arrhythmias, and sudden cardiac death. Mutation screening of LMNA and ARVC-related genes PKP2, DSP, DSG2, DSC2, JUP, and CTNNA3 was performed. We identified a novel heterozygous mutation (c.418_438dup in LMNA gene exon 2, occurring in a highly conserved protein domain across several species. This newly identified variant was not found in 250 ethnically-matched control subjects. Genotype-phenotype correlation studies suggested a co-segregation of the LMNA mutation with the disease phenotype and an incomplete and age-related penetrance. Based on clinical, pedigree, and molecular genetic data, this mutation was considered likely disease-causing. To clarify its potential pathophysiologic impact, functional characterization of this LMNA mutant was performed in cultured cardiomyocytes expressing EGFP-tagged wild-type and mutated LMNA constructs, and indicated an increased nuclear envelope fragility, leading to stress-induced apoptosis as the main pathogenetic mechanism. This study further expands the role of the LMNA gene in the pathogenesis of cardiac laminopathies, suggesting that LMNA should be included in mutation screening of patients with suspected arrhythmogenic cardiomyopathy, particularly when they have ECG evidence for conduction defects. The combination of clinical, genetic, and functional data contribute insights into the pathogenesis of this form of life-threatening arrhythmogenic

  8. QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design.

    van der Does, Lisette J M E; Yaksh, Ameeta; Kik, Charles; Knops, Paul; Lanters, Eva A H; Teuwen, Christophe P; Oei, Frans B S; van de Woestijne, Pieter C; Bekkers, Jos A; Bogers, Ad J J C; Allessie, Maurits A; de Groot, Natasja M S


    The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 5-10 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.

  9. Automatic classification of laser-induced breakdown spectroscopy (LIBS) data of protein biomarker solutions.

    Pokrajac, David; Lazarevic, Aleksandar; Kecman, Vojislav; Marcano, Aristides; Markushin, Yuri; Vance, Tia; Reljin, Natasa; McDaniel, Samantha; Melikechi, Noureddine


    We perform multi-class classification of laser-induced breakdown spectroscopy data of four commercial samples of proteins diluted in phosphate-buffered saline solution at different concentrations: bovine serum albumin, osteopontin, leptin, and insulin-like growth factor II. We achieve this by using principal component analysis as a method for dimensionality reduction. In addition, we apply several different classification algorithms (K-nearest neighbor, classification and regression trees, neural networks, support vector machines, adaptive local hyperplane, and linear discriminant classifiers) to perform multi-class classification. We achieve classification accuracies above 98% by using the linear classifier with 21-31 principal components. We obtain the best detection performance for neural networks, support vector machines, and adaptive local hyperplanes for a range of the number of principal components with no significant differences in performance except for that of the linear classifier. With the optimal number of principal components, a simplistic K-nearest classifier still provided acceptable results. Our proposed approach demonstrates that highly accurate automatic classification of complex protein samples from laser-induced breakdown spectroscopy data can be successfully achieved using principal component analysis with a sufficiently large number of extracted features, followed by a wrapper technique to determine the optimal number of principal components.

  10. Management of a rare case of arrhythmogenic right ventricular dysplasia in pregnancy: a case report

    İşçi Herman


    Full Text Available Abstract Introduction Arrhythmogenic right ventricular dysplasia is a heritable disease of the heart muscle characterized by fibrofatty degeneration of cardiomyocytes. Patients present with ventricular arrhythmias or congestive heart failure, and sometimes sudden cardiac death occurs. Prenatal diagnosis has become possible with the detection of mutations, but, to the best of our knowledge, no case of prenatal diagnosis has been reported previously. There is little information about the management of arrhythmogenic right ventricular dysplasia in pregnancy, and the preferred mode of delivery is not certain; therefore, we present the case of a patient with arrhythmogenic right ventricular dysplasia and discuss the prenatal diagnosis, patient management and prognosis in pregnancy. Case presentation A 26-year-old Caucasian woman who presented to our hospital with heart palpitations was diagnosed with arrhythmogenic right ventricular dysplasia, and, after three years of follow up with anti-arrhythmic drugs, she wanted to conceive. During pregnancy, she ceased taking her medication. She tolerated pregnancy very well but her cardiac symptoms recurred after her 30th week of pregnancy. She delivered a baby via cesarean section under general anesthesia in her 38th week of pregnancy. She was discharged without any medications and continued lactation for six months. Conclusion Patients with mild to moderate arrhythmogenic right ventricular dysplasia tolerate pregnancy and breastfeeding very well, but patients with end-stage arrhythmogenic right ventricular dysplasia should be discouraged from conception.

  11. Procainamide and lidocaine produce dissimilar changes in ventricular repolarization and arrhythmogenicity in guinea-pig.

    Osadchii, Oleg E


    Procainamide is class Ia Na(+) channel blocker that may prolong ventricular repolarization secondary to inhibition of IK r , the rapid component of the delayed rectifier K(+) current. In contrast to selective IN a blockers such as lidocaine, procainamide was shown to produce arrhythmogenic effects in the clinical setting. This study examined whether pro-arrhythmic responses to procainamide may be accounted for by drug-induced repolarization abnormalities including impaired electrical restitution kinetics, spatial gradients in action potential duration (APD), and activation-to-repolarization coupling. In perfused guinea-pig hearts, procainamide was found to prolong the QT interval on ECG and left ventricular (LV) epicardial monophasic APD, increased the maximum slope of electrical restitution, enhanced transepicardial APD variability, and eliminated the inverse correlation between the local APD and activation time values determined at distinct epicardial recording sites prior to drug infusion. In contrast, lidocaine had no effect on electrical restitution, the degree of transepicardial repolarization heterogeneities, and activation-to-repolarization coupling. Spontaneous episodes of monomorphic ventricular tachycardia were observed in 57% of procainamide-treated heart preparations. No arrhythmia was induced by lidocaine. In summary, this study suggests that abnormal changes in repolarization may contribute to pro-arrhythmic effects of procainamide.

  12. The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain.

    Zhou, Yuhong; Wu, Yun; Deng, Lin; Chen, Lanlan; Zhao, Dandan; Lv, Lifang; Chen, Xu; Man, Jinyu; Wang, Yansong; Shan, Hongli; Lu, Yanjie


    Matrine, a alkaloid of the root of Sophora flavescens, has multiple protective effects on the cardiovascular system including cardiac arrhythmias. However, the molecular and ionic mechanisms of matrine have not been well investigated. Our study aimed at to shed a light on the issue to investigate the antiarrhythmic effects of matrine by using ouabain to construct an arrhythmic model of cardiomyocytes. In this experiment, matrine significantly and dose-dependently increased the doses of ouabain required to induce cardiac arrhythmias and decreased the duration of arrhythmias in guinea pigs. In cardiomyocytes of guinea pigs, ouabain 10 μM prolonged action potential duration by 80% (pMatrine 100 μM shortened the prolongation of APD and prevented the increase of L-type Ca(2+) currents and Ca(2+) transients induced by ouabain. Taken together, these findings provide the first evidence that matrine possessed arrhythmogenic effect of ouabain by inhibiting of L-type Ca(2+) currents and Ca(2+) overload in guinea pigs.

  13. Alpha B-crystallin prevents the arrhythmogenic effects of particulate matter isolated from ambient air by attenuating oxidative stress

    Park, Hyelim [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University, Seoul (Korea, Republic of); Park, Sanghoon; Jeon, Hyunju [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Song, Byeong-Wook [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University, Seoul (Korea, Republic of); Kim, Jin-Bae [Division of Cardiology, Kyung Hee University College of Medicine, Seoul (Korea, Republic of); Kim, Chang-Soo [The Department of Preventive Medicine, Yonsei University College of Medicine, Seoul (Korea, Republic of); Pak, Hui-Nam [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Hwang, Ki-Chul [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University, Seoul (Korea, Republic of); Lee, Moon-Hyoung [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Chung, Ji Hyung, E-mail: [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Joung, Boyoung, E-mail: [The Division of Cardiology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University, Seoul (Korea, Republic of)


    Ca{sup 2+}/calmodulin-dependent protein kinase II (CaMKII) is activated by particulate matter (PM) isolated from ambient air and linked to prolonged repolarization and cardiac arrhythmia. We evaluated whether alpha B-crystallin (CryAB), a heat shock protein, could prevent the arrhythmogenic effects of PM by preventing CaMKII activation. CryAB was delivered into cardiac cells using a TAT-protein transduction domain (TAT-CryAB). ECGs were measured before and after tracheal exposure of diesel exhaust particles (DEP) and each intervention in adult Sprague–Dawley rats. After endotracheal exposure of DEP (200 μg/mL for 30 minutes, n = 11), QT intervals were prolonged from 115 ± 14 ms to 144 ± 20 ms (p = 0.03), and premature ventricular contractions were observed more frequently (0% vs. 44%) than control (n = 5) and TAT-Cry (n = 5). However, DEP-induced arrhythmia was not observed in TAT-CryAB (1 mg/kg) pretreated rats (n = 5). In optical mapping of Langendorff-perfused rat heats, compared with baseline, DEP infusion of 12.5 μg/mL (n = 12) increased apicobasal action potential duration (APD) differences from 2 ± 6 ms to 36 ± 15 ms (p < 0.001), APD restitution slope from 0.26 ± 0.07 to 1.19 ± 0.11 (p < 0.001) and ventricular tachycardia (VT) from 0% to 75% (p < 0.001). DEP infusion easily induced spatially discordant alternans. However, the effects of DEP were prevented by TAT-CryAB (1 mg/kg, n = 9). In rat myocytes, while DEP increased reactive oxygen species (ROS) generation and phosphated CaMKII, TAT-CryAB prevented these effects. In conclusion, CryAB, a small heat shock protein, might prevent the arrhythmogenic effects of PM by attenuating ROS generation and CaMKII activation. -- Highlights: ► Particulate matter (PM) increases arrhythmia. ► PM induced arrhythmias are related with oxidative stress and CaMKII activation. ► Alpha B-crystallin (CryAB) could attenuate the arrhythmogenic effect of PM. ► CryAB decreases oxidative stress and CaMKII activation

  14. Combining network and array waveform coherence for automatic location: examples from induced seismicity monitoring

    Sick, Benjamin; Joswig, Manfred


    Events from induced seismicity suffer from low signal-to-noise ratios and noise spikes due to the industrial setting. Low magnitude thresholds are needed for traffic light warning systems. Conventional automatic location methods rely on independent picking of first arrivals from seismic wave onsets at recordings of single stations. Picking is done separately and without feedback from the actual location algorithm. If the recording network is small or only few phases can be associated, single wrong associations can lead to large errors in hypocentre locations and magnitude. Event location by source scanning which was established in the last two decades can provide more robust results. This study investigates how source-scanning can be extended and improved by integrating information from seismic arrays, that is, waveform stacking and Fisher ratio. These array methods rely on the coherency of the raw filtered waveforms while traditional source scanning uses a characteristic function to obtain coherency from otherwise incoherent waveforms between distant stations. Short-term/long-term average (STA/LTA) serves as the characteristic function and single station vertical-component traces for P-phases and radial and transverse components for S-phases are used. For array stations, the STA/LTA of the stacked vertical seismogram which is furthermore weighted by the STA/LTA of the Fisher ratio, dependent on backazimuth and slowness, is utilized for P-phases. The new method is tested on two diverse data sets from induced seismicity monitoring. In the chosen examples, the extension by array-processing techniques can reduce mean hypocentre errors up to a factor of 2.9, resolve ambiguities and further restrain the location.

  15. The value of magnetic resonance imaging for the diagnosis of arrhythmogenic right ventricular cardiomyopathy

    Maksimovic, Ruzica [Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim (Germany); Clinical Center of Serbia, Department of Cardiology, Institute for Cardiovascular Diseases, Belgrade (Czechoslovakia); Ekinci, Okan; Reiner, Christian; Hamm, Christian W.; Pitschner, Heinz-F.; Dill, Thorsten [Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim (Germany); Bachmann, Georg F. [Kerckhoff Heart Center, Department of Radiology, Bad Nauheim (Germany); Seferovic, Petar M.; Ristic, Arsen D. [Clinical Center of Serbia, Department of Cardiology, Institute for Cardiovascular Diseases, Belgrade (Czechoslovakia)


    This study evaluated the diagnostic significance of a magnetic resonance imaging (MRI) based scoring model for identification of arrhythmogenic right ventricular cardiomyopathy (ARVC) in patients with MRI evidence of RV abnormalities. Fifty-three patients with RV myocardial abnormalities on MRI were divided into a group with ARVC 1 (n=17) and a group with other RV arrhythmias (n=37). Decision tree learning (DTL) and linear classification (based on a modified ARVC scoring model of major and minor criteria) were used to identify and assess MRI criterion information value, and to induce ARVC diagnostic rules. All major ARVC criteria were more frequent in the ARVC group. Among minor criteria regional RV hypokinesia, mild segmental RV dilatation, and prominent trabeculae were more frequent in the ARVC group while mild global RV dilatation was more frequent in the non-ARVC group. RV aneurysm achieved highest importance in ARVC diagnosis (predictive accuracy 76.8%). Better diagnostic accuracy (sensitivity 93.3%, specificity 89.5%) was achieved when the MRI score for the major and minor criteria reached threshold value of four: two major criteria, or one major and two minor, or four minor criteria. Combinations between major and minor criteria contributed to a statistically valid model for ARVC diagnosis. (orig.)

  16. QRS fragmentation: its role in sherlocking the arrhythmogenic heart

    Hafeez Ul Hassan Virk


    Full Text Available The electrocardiogram (ECG is a commonly available basic diagnostic modality in in-patient, out-patient, and emergency departments. In patients with coronary artery disease (CAD, the presence of a fragmented QRS (f-QRS, which is an extra R wave (R′, notching of the single R wave, notching of the S wave in at least two contiguous leads on the 12-lead ECG, is associated with a myocardial scar from previous myocardial injury. Furthermore, the presence of f-QRS has been shown to be associated with adverse outcomes in CAD and non-CAD patients. In the present paper, we will solely focus on the usefulness and utilization of f-QRS in predicting ventricular tachyarrhythmia in many heart diseases, that is, ischemic cardiomyopathy, non-ischemic cardiomyopathy, hypertrophic obstructive cardiomyopathy, Brugada syndrome, and arrhythmogenic right ventricular cardiomyopathy. In the majority of such cases, ventricular tachyarrhythmia results in sudden cardiac death. Diagnosing them beforehand can lead to prevention and/or early treatment of these arrhythmias to prevent potential morbidity and mortality.

  17. Arrhythmogenic right ventricular cardiomyopathy--time for Nordic cooperation!

    Gjesdal, Knut


    This editorial discusses arrhythmogenic right ventricular cardiomyopathy (ARVC) with respect to diagnosis and organisation of patient care. Two papers in the current issue are commented upon. Aneq and coworkers present a long-term echocardiographic study on ARVC patients. Baseline changes were seldom diagnostic, but over years, changes in right ventricular structure and function occurred; the most consistent being increasing diameter of the right ventricular outflow tract. Haapalaita and coworkers used body surface ECG, comparing right and left ventricular types of ECG. The duration of electrical systole (QT-end) and the dispersion of the action potentials (QT peak-end) was longer in the right-sided compared to the left-sided leads in ARVC, at variance from in healthy controls, and the shortening effect of autonomic manoeuvres that activate sympathetic tone, was much more marked on the right side, compatible with the tendency of arrhythmias to occur under stress. An initiative to create a Nordic registry on ARVC has come from Denmark. This is highly welcomed; our individual institutions are too small to gain the experience needed for optimal patient care.

  18. Ryanodine Receptor Phosphorylation by CaMKII Promotes Spontaneous Ca2+ Release Events in a Rodent Model of Early Stage Diabetes: the Arrhythmogenic Substrate

    Sommese, Leandro; Valverde, Carlos A; Blanco, Paula; Castro, María Cecilia; Rueda, Omar Velez; Kaetzel, Marcia; Dedman, John; Anderson, Mark E.; Mattiazzi, Alicia; Palomeque, Julieta


    Background Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species (ROS) and subclinical cardiovascular defects. Although multifunctional Ca2+ calmodulin-dependent protein kinase II (CaMKII) is ROS-activated and CaMKII hyperactivity promotes cardiac diseases, a link between prediabetes and CaMKII in the heart is unprecedented. Objectives to prove the hypothesis that increased ROS and CaMKII activity contribute to heart failure and arrhythmogenic mechanisms in early stage diabetes. Methods-Results Echocardiography, electrocardiography, biochemical and intracellular Ca2+ (Ca2+i) determinations were performed in fructose-rich diet -induced impaired glucose tolerance, a prediabetes model, in rodents. Fructose-rich diet rats showed decreased contractility and hypertrophy associated with increased CaMKII activity, ROS production, oxidized CaMKII and enhanced CaMKII-dependent ryanodine receptor (RyR2) phosphorylation compared to rats fed with control diet. Isolated cardiomyocytes from fructose-rich diet showed increased spontaneous Ca2+i release events associated with spontaneous contractions, which were prevented by KN-93, a CaMKII inhibitor, or addition of Tempol, a ROS scavenger, to the diet. Moreover, fructose-rich diet myocytes showed increased diastolic Ca2+ during the burst of spontaneous Ca2+i release events. Micetreated with Tempol or with sarcoplasmic reticulum-targeted CaMKII-inhibition by transgenic expression of the CaMKII inhibitory peptide AIP, were protected from fructose-rich diet-induced spontaneous Ca2+i release events, spontaneous contractions and arrhythmogenes is in vivo, despite ROS increases. Conclusions RyR2 phosphorylation by ROS-activated CaMKII, contributes to impaired glucose tolerance-induced arrhythmogenic mechanisms, suggesting that CaMKII inhibition could prevent prediabetic

  19. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

    Anna L. Lahti


    Long QT syndrome (LQTS is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2 and drug-induced LQTS both result from altered function of the hERG channel. We investigated whether the electrophysiological characteristics of LQT2 can be recapitulated in vitro using induced pluripotent stem cell (iPSC technology. Spontaneously beating cardiomyocytes were differentiated from two iPSC lines derived from an individual with LQT2 carrying the R176W mutation in the KCNH2 (HERG gene. The individual had been asymptomatic except for occasional palpitations, but his sister and father had died suddenly at an early age. Electrophysiological properties of LQT2-specific cardiomyocytes were studied using microelectrode array and patch-clamp, and were compared with those of cardiomyocytes derived from control cells. The action potential duration of LQT2-specific cardiomyocytes was significantly longer than that of control cardiomyocytes, and the rapid delayed potassium channel (IKr density of the LQT2 cardiomyocytes was significantly reduced. Additionally, LQT2-derived cardiac cells were more sensitive than controls to potentially arrhythmogenic drugs, including sotalol, and demonstrated arrhythmogenic electrical activity. Consistent with clinical observations, the LQT2 cardiomyocytes demonstrated a more pronounced inverse correlation between the beating rate and repolarization time compared with control cells. Prolonged action potential is present in LQT2-specific cardiomyocytes derived from a mutation carrier and arrhythmias can be triggered by a commonly used drug. Thus, the iPSC-derived, disease-specific cardiomyocytes could serve as an important platform to study pathophysiological mechanisms and drug sensitivity in LQT2.

  20. The effects of quinidine and verapamil on electrically induced automaticity in the ventricular myocardium of guinea pig.

    Grant, A O; Katzung, B G


    The effects of 2 to 10 muM verapamil (1-5 mg/l) and 3.8 to 7.6 muM quinidine (2-4 mg/l) on automaticity in ventricular myocardial fibers were examined. Papillary muscles from guinea pigs were mounted in a sucrose gap chamber and transmembrane potential was recorded by standard microelectrode techniques. Automaticity was induced with depolarizing currents of various strengths. Verapamil reduced phase 4 slope at all maximum diastolic membrane potentials. It also caused a selective reduction of the overshoot of action potentials arising from less negative maximum diastolic potentials. During exposure to verapamil, increased [Ca]0 partially restored action potential overshoot, but phase 4 slope was further reduced. Epinephrine caused a partial or complete reversal of verapamil-induced phase 4 slope depression but usually did not restore action potential overshoot. Quinidine reduced phase 4 slope at all maximum diastolic potentials. There was less marked reduction of action potential overshoot than in the case of verapamil. Epinephrine caused a partial reversal of the reduction of phase 4 slope produced by quinidine. It is concluded that although both verapamil and quinidine reduce automaticity in ventricular fibers, verapamil may be more effective in reducing the amplitude and occurrence of action potentials arising from low maximum diastolic potentials.

  1. Arrhythmogenic right ventricular cardiomyopathy a still underrecognized clinic entity.

    Thiene, G; Basso, C; Danieli, G; Rampazzo, A; Corrado, D; Nava, A


    Arrhythmogenic right ventricular cardiomyopathy is a new morbid entity that was discovered thanks to the study of sudden death in the young. This heart muscle disease is characterized by myocardial atrophy, mostly of the right ventricle, with massive fibro-fatty infiltration, accounting for ventricular electrical instability at risk of severe arrhythmias and even cardiac arrest. The disease was found to be the major cause of sudden death in young people and athletes in the Veneto Region, Italy. A familial occurrence with autosomal dominant transmission was then discovered, and the prevalence was estimated to be higher than 1 in 5000. The disease is genetically heterogeneous: Linkage analysis, carried out in a large family with recurrence of sudden deaths, led to map the gene to chromosome 14q23-q24. Linkage analysis in a second family allowed mapping of another gene to chromosome 1q42-q43. Clinical diagnosis can be achieved through electrocardiography, echocardiography, angiocardiography, magnetic resonance imaging, and endomyocardial biopsy. Diagnostic criteria have been put forward by a committee of the International Society and Federation of Cardiology. The disease was recently included among the cardiomyopathies in the revised World Health Organization (WHO) classification. Study of the natural history allowed us to distinguish (a) a covert phase in apparently normal subjects who have a risk of abrupt electrical instability and sudden death, (b) an overt arrhythmic phase with palpitations and impending cardiac arrest, (c) congestive heart failure with pump depression, sometimes so severe as to require heart transplantation. Both the etiology and pathogenesis of the disease are unknown. In particular, the mechanisms leading to progressive loss of myocardium and fibro-fatty replacement are still speculative. Apoptosis in the right ventricle occurring not only in infancy, as in the normal heart, but also in childhood and adulthood might account for the progressive

  2. Clinical Significance of Epsilon Waves in Arrhythmogenic Cardiomyopathy.

    Protonotarios, Alexandros; Anastasakis, Aris; Tsatsopoulou, Adalena; Antoniades, Loizos; Prappa, Efstathia; Syrris, Petros; Tousoulis, Dimitrios; McKENNA, William J; Protonotarios, Nikos


    Epsilon waves are hallmark features of arrhythmogenic cardiomyopathy (ACM) but information about their clinical significance is variable. We evaluated epsilon wave prevalence, characteristics, and their clinical significance in an ACM population. Eighty-six unselected patients fulfilling the 2010 Task Force criteria were enrolled. Seventy-six of them were carriers of desmosomal mutations. All subjects were serially evaluated with standard 12-lead ECG and 2-dimensional echocardiography. Epsilon waves were evaluated in all precordial and inferior leads. Novel parameters assessed included their duration and precordial/inferior lead extension. Twenty-five subjects (29%) had epsilon waves that were present in lead V3 and beyond in 9, and in the inferior leads in 7. Epsilon waves were associated with right ventricular outflow tract (RVOT) (P = 0.001) but not RV posterior wall (P = 0.21), RV apex (P = 0.30), or left ventricular (P = 0.94) wall motion abnormalities. Patients with epsilon waves had increased RVOT diameter (P waves in lead V3 and beyond was associated with increased epsilon wave duration (P = 0.002) and RVOT diameter (P = 0.04). The duration of epsilon waves was positively correlated with RVOT diameter (r = 0.70, P = 0.0001). Epsilon waves were also associated with episodes of sustained ventricular tachycardia (P = 0.004) but not with heart failure (P = 0.41) or sudden cardiac death (P = 0.31). Detection of epsilon waves on 12-lead ECG reflects significant RVOT involvement, which was associated with episodes of sustained ventricular tachycardia but not sudden cardiac death. © 2015 Wiley Periodicals, Inc.

  3. Arrhythmogenic right ventricular cardiomyopathy: considerations from in silico experiments

    Ronald eWilders


    Full Text Available Objective: Arrhythmogenic right ventricular cardiomyopathy (ARVC is associated with remodelling of gap junctions and also, although less well-defined, down-regulation of the fast sodium current. The gap junction remodelling and down-regulation of sodium current have been proposed as contributors to arrhythmo¬genesis in ARVC by slowing conduction. The objective of the present study was to assess the amount of conduction slowing due to the observed gap junction remodelling and down-regulation of sodium current.Methods: The effects of (changes in gap junctional conductance, cell dimensions and sodium current on both longitudinal and transversal con¬duction velocity were tested by simulating action potential propagation in linear strands of human ventricular cells that were either arranged end-to-end or side-by-side.Results: A 50% reduction in gap junction content, as commonly observed in ARVC, gives rise to an 11% decrease in longitudinal conduction velocity and a 29% decrease in transverse conduction velocity. A down-regulation of the sodium current through a 50% decrease in peak current density as well as a −15 mV shift in steady-state inactivation, as observed in an experimental model of ARVC, decreases conduction velocity in either direction by 32%. In combination, the gap junction remodelling and down-regulation of sodium current result in a 40% decrease in longitudinal conduction velocity and a 52% decrease in transverse conduction velocity.Conclusions: The gap junction remodelling and down-regulation of sodium current do result in conduction slowing, but heterogeneity of gap junction remodelling, in combination with down-regulation of sodium current, rather than gap junction remodelling per se may be a critical factor in arrhythmogenesis in ARVC.

  4. Mutation analysis and evaluation of the cardiac localization of TMEM43 in arrhythmogenic right ventricular cardiomyopathy

    Christensen, A H; Andersen, C B; Tybjærg-Hansen, A;


    Christensen AH, Andersen CB, Tybjærg-Hansen A, Haunso S, Svendsen JH. Mutation analysis and evaluation of the cardiac localization of TMEM43 in arrhythmogenic right ventricular cardiomyopathy. A single report has associated mutations in TMEM43 (LUMA) with a distinctive form of arrhythmogenic right...... with anti-TMEM43, anti-plakoglobin, anti-plakophilin-2, anti-connexin-43, and anti-emerin antibodies was performed on myocardium from TMEM43-positive patients (n = 3) and healthy controls (n = 3). The genetic screening identified heterozygous variants in two families: one reported mutation (c.1073C> T...

  5. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy

    Pilichou, K.; Remme, C.A.; Basso, C.; Campian, M.E.; Rizzo, S.; Barnett, P.; Scicluna, B.P.; Bauce, B.; van den Hoff, M.J.B.; de Bakker, J.M.T.; Tan, H.L.; Valente, M.; Nava, A.; Wilde, A.A.M.; Moorman, A.F.M.; Thiene, G.; Bezzina, C.R.


    Mutations in the cardiac desmosomal protein desmoglein-2 (DSG2) are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC). We studied the explanted heart of a proband carrying the DSG2-N266S mutation as well as transgenic mice (Tg-NS) with cardiac overexpression of the mouse equival

  6. Pregnancy course and outcomes in women with arrhythmogenic right ventricular cardiomyopathy

    Hodes, Anke R; Tichnell, Crystal; Te Riele, Anneline S J M; Murray, Brittney; Groeneweg, Judith A; Sawant, Abhishek C; Russell, Stuart D; van Spaendonck-Zwarts, Karin Y; van den Berg, Maarten P; Wilde, Arthur A; Tandri, Harikrishna; Judge, Daniel P; Hauer, Richard N W; Calkins, Hugh; van Tintelen, J Peter; James, Cynthia A


    OBJECTIVES: To characterise pregnancy course and outcomes in women with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). METHODS: From a combined Johns Hopkins/Dutch ARVD/C registry, we identified 26 women affected with ARVD/C (by 2010 Task Force Criteria) during 39 singleton preg

  7. Approach to family screening in arrhythmogenic right ventricular dysplasia/cardiomyopathy

    Te Riele, Anneline S J M; James, Cynthia A; Groeneweg, Judith A; Sawant, Abhishek C; Kammers, Kai; Murray, Brittney; Tichnell, Crystal; van der Heijden, Jeroen F; Judge, Daniel P; Dooijes, Dennis; van Tintelen, J Peter; Hauer, Richard N W; Calkins, Hugh; Tandri, Harikrishna


    AIMS: A combination of variable expression, age-related penetrance, and unpredictable arrhythmic events complicates management of relatives of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) patients. We aimed to (i) determine predictors of ARVD/C diagnosis and (ii) optimize arrhy

  8. Electroanatomic Correlates of Depolarization Abnormalities in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

    Tanawuttiwat, Tanyanan; Te Riele, Anneline S J M; Philips, Binu; James, Cynthia A; Murray, Brittney; Tichnell, Crystal; Sawant, Abhishek C; Calkins, Hugh; Tandri, Harikrishna


    BACKGROUND: Epsilon waves and other depolarization abnormalities in the right precordial leads are thought to represent delayed activation of the right ventricular outflow tract in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, no study has directly correlated cardiac e

  9. Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers

    Bhonsale, Aditya; Groeneweg, Judith A.; James, Cynthia A.; Dooijes, Dennis; Tichnell, Crystal; Jongbloed, Jan D. H.; Murray, Brittney; Riele, Anneline S. J. M. te; van den Berg, Maarten P.; Bikker, Hennie; Atsma, Douwe E.; de Groot, Natasja M.; Houweling, Arjan C.; van der Heijden, Jeroen F.; Russell, Stuart D.; Doevendans, Pieter A.; van Veen, Toon A.; Tandri, Harikrishna; Wilde, Arthur A.; Judge, Daniel P.; van Tintelen, J. Peter; Calkins, Hugh; Hauer, Richard N.


    AIMS: We sought to determine the influence of genotype on clinical course and arrhythmic outcome among arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated mutation carriers. METHODS AND RESULTS: Pathogenic mutations in desmosomal and non-desmosomal genes were identified in

  10. Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy

    Mavroidis, Manolis; Davos, Constantinos H.; Psarras, Stelios; Varela, Aimilia; Athanasiadis, Nikolaos C.; Katsimpoulas, Michalis; Kostavasili, Ioanna; Maasch, Christian; Vater, Axel; van Tintelen, J. Peter; Capetanaki, Yassemi


    Inflammation may contribute to disease progression in arrhythmogenic cardiomyopathy (ACM). However, its role in this process is unresolved. Our goal was to delineate the pathogenic role of the complement system in a new animal model of ACM and in human disease. Using cardiac histology, echocardiogra

  11. Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia-Associated Mutations From Background Genetic Noise

    Kapplinger, Jamie D.; Landstrom, Andrew P.; Salisbury, Benjamin A.; Callis, Thomas E.; Pollevick, Guido D.; Tester, David J.; Cox, Moniek G. P. J.; Bhuiyan, Zahir; Bikker, Hennie; Wiesfeld, Ans C. P.; Hauer, Richard N. W.; van Tintelen, J. Peter; Jongbloed, Jan D. H.; Calkins, Hugh; Judge, Daniel P.; Wilde, Arthur A. M.; Ackerman, Michael J.


    Objectives The aims of this study were to determine the spectrum and prevalence of "background genetic noise" in the arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC) genetic test and to determine genetic associations that can guide the interpretation of a positive test result. Backgr

  12. Left-dominant arrhythmogenic cardiomyopathy in a large family : Associated desmosomal or nondesmosomal genotype?

    Groeneweg, Judith A.; van der Zwaag, Paul A.; Jongbloed, Jan D. H.; Cox, Moniek G. P. J.; Vreeker, Arnold; de Boer, Rudolf A.; van der Heijden, Jeroen F.; van Veen, Toon A. B.; McKenna, William J.; van Tintelen, J. Peter; Dooijes, Dennis; Hauer, Richard N. W.


    BACKGROUND Arrhythmogenic cardiomyopathy (AC) is considered a predominantly right ventricular (RV) desmosomal disease. However, left-dominant forms due to desmosomal gene mutations, including PKP2 variant c.419C>T, have been described. Recently, a nondesmosomal phospholamban (PLN) mutation (c.40_42d

  13. Arrhythmogenic right ventricular dysplasia/cardiomyopathy diagnostic task force criteria: impact of new task force criteria

    M.G.P.J. Cox; J.J. van der Smagt; M. Noorman; A.C. Wiesfeld; P.G.A. Volders; I.M. van Langen; D.E. Atsma; D. Dooijes; A.C. Houweling; P. Loh; L. Jordaens; Y. Arens; M.J. Cramer; P.A. Doevendans; J.P. van Tintelen; A.A.M. Wilde; R.N.W. Hauer


    BACKGROUND: Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) Diagnostic Task Force Criteria (TFC) proposed in 1994 are highly specific but lack sensitivity. A new international task force modified criteria to improve diagnostic yield. A comparison of diagnosis by 1994 TFC versus ne

  14. Right ventricular strain by MR quantitatively identifies regional dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy

    Vigneault, Davis M; te Riele, Anneline S J M; James, Cynthia A; Zimmerman, Stefan L; Selwaness, Mariana; Murray, Brittney; Tichnell, Crystal; Tee, Michael; Noble, J Alison; Calkins, Hugh; Tandri, Harikrishna; Bluemke, David A


    BACKGROUND: Analysis of regional wall motion of the right ventricle (RV) is primarily qualitative with large interobserver variation in clinical practice. Thus, the purpose of this study was to use feature tracking to analyze regional wall motion abnormalities in patients with arrhythmogenic right v

  15. Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients - disease - causing or innocent bystanders?

    Christensen, A.H.; Benn, M.; Tybjaerg-Hansen, A.


    Objectives: Mutations in genes encoding desmosomal proteins have been linked to arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). We hypothesized that a Scandinavian ARVC/D population would have a different spectrum of plakophilin-2 (PKP2) mutations and that some of the reported...

  16. Congenital short QT syndrome: landmarks of the newest arrhythmogenic cardiac channelopathy.

    Pérez Riera, Andrés Ricardo; Paixão-Almeida, Adail; Barbosa-Barros, Raimundo; Yanowitz, Frank G; Baranchuk, Adrian; Dubner, Sergio; Palandri Chagas, Antônio Carlos


    Congenital or familial short QT syndrome is a genetically heterogeneous cardiac channelopathy without structural heart disease that has a dominant autosomal or sporadic pattern of transmission affecting the electric system of the heart. Patients present clinically with a spectrum of signs and symptoms including irregular palpitations due to episodes of paroxysmal atrialfibrillation, dizziness and fainting (syncope) and/or sudden cardiac death due to polymorphic ventricular tachycardia and ventricular fibrillation. Electrocardiographic (ECG) findings include extremely short QTc intervals (QTc interval ≤330 ms) not significantly modified with heart rate changes and T waves of great voltage witha narrow base. Electrophysiologic studies are characterized by significant shortening of atrial and ventricular refractory periods and arrhythmias induced by programmed stimulation. A few families have been identified with specific genotypes: 3 with mutations in potassium channels called SQT1 (Iks), SQT2 (Ikr) and SQT3 (Ik1). These 3 potassium channel variants are the "genetic mirror image" of long QT syndrome type 2, type 1 and Andersen-Tawil syndrome respectively because they exert opposite gain-of-function effects on the potassium channels in contrast to the loss-of-function of the potassium channels in the long QT syndromes. Three new variants with overlapping phenotypes affecting the slow inward calcium channels havealso been described. Finally, another variant with mixed phenotype affecting the sodium channel was reported. This review focuses the landmarks of this newest arrhythmogenic cardiac channelopathy on the main clinical, genetic, and proposed ECG mechanisms. In addition therapeutic options and the molecular autopsy of this fascinating primary electrical heart disease are discussed.

  17. Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers.

    Quednow, Boris B; Kometer, Michael; Geyer, Mark A; Vollenweider, Franz X


    The serotonin-2A receptor (5-HT(2A)R) has been implicated in the pathogenesis of schizophrenia and related inhibitory gating and behavioral inhibition deficits of schizophrenia patients. The hallucinogen psilocybin disrupts automatic forms of sensorimotor gating and response inhibition in humans, but it is unclear so far whether the 5-HT(2A)R or 5-HT(1A)R agonist properties of its bioactive metabolite psilocin account for these effects. Thus, we investigated whether psilocybin-induced deficits in automatic and controlled inhibition in healthy humans could be attenuated by the 5-HT(2A/2C)R antagonist ketanserin. A total of 16 healthy participants received placebo, ketanserin (40 mg p.o.), psilocybin (260 μg/kg p.o.), or psilocybin plus ketanserin in a double-blind, randomized, and counterbalanced order. Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle response. The effects on psychopathological core dimensions and behavioral inhibition were assessed by the altered states of consciousness questionnaire (5D-ASC), and the Color-Word Stroop Test. Psilocybin decreased PPI at short lead intervals (30 ms), increased all 5D-ASC scores, and selectively increased errors in the interference condition of the Stroop Test. Stroop interference and Stroop effect of the response latencies were increased under psilocybin as well. Psilocybin-induced alterations were attenuated by ketanserin pretreatment, whereas ketanserin alone had no significant effects. These findings suggest that the disrupting effects of psilocybin on automatic and controlled inhibition processes are attributable to 5-HT(2A)R stimulation. Sensorimotor gating and attentional control deficits of schizophrenia patients might be due to changes within the 5-HT(2A)R system.

  18. Left Ventricular Involvement in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Assessed by Echocardiography Predicts Adverse Clinical Outcome

    Mast, Thomas P.; Teske, Arco J.; van der Heijden, Jeroen F.; Groeneweg, Judith A.; Te Riele, Anneline S J M; Velthuis, Birgitta K.; Hauer, RNW; Doevendans, Pieter A.; Cramer, Maarten J.


    Background Among studies describing the phenotype of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), significant discrepancy exists regarding the extent and impact of left ventricular (LV) involvement. The capability of conventional and new quantitative echocardiographic techniqu

  19. Transcatheter closure of atrial septal defect associated with arrhythmogenic right ventricular cardiomyopathy: a case report and literature review.

    Wang, Haiyan; Ding, Hongyu; Lei, Lei; Zhang, Xiaohong; Gong, Yuling; Hou, Yinglong


    Arrhythmogenic right ventricular cardiomyopathy is characterised by progressive, fibrofatty replacement of myocardium, and ventricular arrhythmias, and its prognosis is usually poor. Arrhythmogenic right ventricular cardiomyopathy associated with atrial septal defect is very rare, and this combination may make the diagnosis, treatment, and prognosis difficult. We present a case of a patient with this association who underwent interventional treatment with a septal defect occluder. Transcatheter closure of atrial septal defect in a patient with arrhythmogenic right ventricular cardiomyopathy is hitherto unreported. During a 3-year follow-up he remained relatively stable. We also review the cases reported in the medical literature describing this uncommon association between arrhythmogenic right ventricular cardiomyopathy and atrial septal defect or patent foramen ovale.

  20. Long-term abacus training induces automatic processing of abacus numbers in children.

    Du, Fenglei; Yao, Yuan; Zhang, Qiong; Chen, Feiyan


    Abacus-based mental calculation (AMC) is a unique strategy for arithmetic that is based on the mental abacus. AMC experts can solve calculation problems with extraordinarily fast speed and high accuracy. Previous studies have demonstrated that abacus experts showed superior performance and special neural correlates during numerical tasks. However, most of those studies focused on the perception and cognition of Arabic numbers. It remains unclear how the abacus numbers were perceived. By applying a similar enumeration Stroop task, in which participants are presented with a visual display containing two abacus numbers and asked to compare the numerosity of beads that consisted of the abacus number, in the present study we investigated the automatic processing of the numerical value of abacus numbers in abacus-trained children. The results demonstrated a significant congruity effect in the numerosity comparison task for abacus-trained children, in both reaction time and error rate analysis. These results suggested that the numerical value of abacus numbers was perceived automatically by the abacus-trained children after long-term training.

  1. Value of the Signal-Averaged Electrocardiogram in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

    Kamath, Ganesh S.; Zareba, Wojciech; Delaney, Jessica; Koneru, Jayanthi N.; McKenna, William; Gear, Kathleen; Polonsky, Slava; Sherrill, Duane; Bluemke, David; Marcus, Frank; Steinberg, Jonathan S.


    Background Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited disease causing structural and functional abnormalities of the right ventricle (RV). The presence of late potentials as assessed by the signal averaged electrocardiogram (SAECG) is a minor Task Force criterion. Objective The purpose of this study was to examine the diagnostic and clinical value of the SAECG in a large population of genotyped ARVC/D probands. Methods We compared the SAECGs of 87 ARVC/D probands (age 37 ± 13 years, 47 males) diagnosed as affected or borderline by Task Force criteria without using the SAECG criterion with 103 control subjects. The association of SAECG abnormalities was also correlated with clinical presentation; surface ECG; VT inducibility at electrophysiologic testing; ICD therapy for VT; and RV abnormalities as assessed by cardiac magnetic resonance imaging (cMRI). Results When compared with controls, all 3 components of the SAECG were highly associated with the diagnosis of ARVC/D (p<0.001). These include the filtered QRS duration (fQRSD) (97.8 ± 8.7 msec vs. 119.6 ± 23.8 msec), low amplitude signal (LAS) (24.4 ± 9.2 msec vs. 46.2 ± 23.7 msec) and root mean square amplitude of the last 40 msec of late potentials (RMS-40) (50.4 ± 26.9 µV vs. 27.9 ± 36.3 µV). The sensitivity of using SAECG for diagnosis of ARVC/D was increased from 47% using the established 2 of 3 criteria (i.e. late potentials) to 69% by using a modified criterion of any 1 of the 3 criteria, while maintaining a high specificity of 95%. Abnormal SAECG as defined by this modified criteria was associated with a dilated RV volume and decreased RV ejection fraction detected by cMRI (p<0.05). SAECG abnormalities did not vary with clinical presentation or reliably predict spontaneous or inducible VT, and had limited correlation with ECG findings. Conclusion Using 1 of 3 SAECG criteria contributed to increased sensitivity and specificity for the diagnosis of ARVC/D. This

  2. Automatic mode switching of a dual chamber implantable cardioverter-defibrillator induced by a ventricular escape rhythm.

    Barold, S Serge; Van Heuverswyn, Frederic; Stroobandt, Roland X


    This report describes a form of group beating induced by a St Jude dual chamber ICD which interpreted a ventricular escape rhythm (with retrograde conduction) as premature ventricular complexes (PVC). These pacemaker-defined PVCs activated the atrial pace-PVC algorithm in 2 steps. 1. The postventricular atrial refractory period (PVARP) was terminated upon detecting a retrograde P wave within its unblanked portion, and 2. An atrial stimulus was released 330ms after the end of the PVARP. This response resulted in automatic mode switching because the 330ms interatrial interval was shorter than the atrial tachycardia detection interval. The arrhythmia may be considered to represent an unusual form of pacemaker escape-capture bigeminy.

  3. Arrhythmogenic Noncompaction Cardiomyopathy: Is There an Echocardiographic Phenotypic Overlap of Two Distinct Cardiomyopathies?

    Aras, Dursun; Ozeke, Ozcan; Cay, Serkan; Ozcan, Firat; Baser, Kazım; Dogan, Umuttan; Unlu, Murat; Demirkan, Burcu; Tufekcioglu, Omac; Topaloglu, Serkan


    The clinical diagnosis of right ventricular (RV) cardiomyopathies is often challenging. It is difficult to differentiate the isolated left ventricular (LV) noncompaction cardiomyopathy (NC) from biventricular NC or from coexisting arrhythmogenic ventricular cardiomyopathy (AC). There are currently few established morphologic criteria for the diagnosis other than RV dilation and presence of excessive regional trabeculation. The gross and microscopic changes suggest pathological similarities between, or coexistence of, RV-NC and AC. Therefore, the term arrhythmogenic right ventricular cardiomyopathy is somewhat misleading as isolated LV or biventricular involvement may be present and thus a broader term such as AC should be preferred. We describe an unusual case of AC associated with a NC in a 27-year-old man who had a history of permanent pacemaker 7 years ago due to second-degree atrioventricular block.

  4. Kocher-Debre-Semelaigne syndrome with arrhythmogenic right ventricular cardiomyopathy: A hitherto unrecognized association

    Nagaraja Moorthy


    Full Text Available Kocher-Debre-Semelaigne (KDS syndrome is a rare form of hypothyroid myopathy, with associated hypertrophy of muscles. Although cardiac manifestations of hypothyroidism are well known, reports of cardiac involvement in KDS have only described the occurrence of pericardial effusion as an association. This report describes an adolescent male presenting with typical features of this rare syndrome along with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D, an association not yet described in the literature.

  5. Exploitation of linguistic indicators for automatic weighting of synonyms induced within three biomedical terminologies.

    Grabar, Natalia; Hamon, Thierry


    Acquisition and enrichment of lexical resources is an important research area for the computational linguistics. We propose a method for inducing a lexicon of synonyms and for its weighting in order to establish its reliability. The method is based on the analysis of syntactic structure of complex terms. We apply and evaluate the approach on three biomedical terminologies (MeSH, Snomed Int, Snomed CT). Between 7.7 and 33.6% of the induced synonyms are ambiguous and cooccur with other semantic relations. A virtual reference allows to validate 9 to 14% of the induced synonyms.

  6. Role of novel DSP_p.Q986X genetic variation in arrhythmogenic right ventricular cardiomyopathy.

    Campuzano, Oscar; Alcalde, Mireia; Berne, Paola; Zorio, Esther; Iglesias, Anna; Navarro-Manchón, Josep; Brugada, Josep; Brugada, Ramon


    Arrhythmogenic right ventricular cardiomyopathy is an inherited disease characterized by a progressive myocardium fibrofatty replacement. This abnormality disrupts electrical transmission causing ventricular arrhythmias and sudden cardiac death. This genetic disease is transmitted mainly with an autosomal dominant pattern. Our aim was to identify the genetic defect responsible for the pathology in a Spanish family, and to perform its phenotype connotations. A total of 15 individuals in a three-generation Spanish family were screened after the sudden cardiac death of one family member. All they underwent a complete physical examination, 12-lead electrocardiogram, 2-dimensional echocardiography, magnetic resonance imaging, exercise stress test, 24-h Holter and genetic testing. Autopsy revealed the presence of biventricular arrhythmogenic dysplasia in deceased member. Six family members showed clinical symptoms but only three of them fulfilled definite diagnostic criteria of the disease. Genetic analysis showed a novel nonsense genetic variation in nine family members. All family members with clinical symptoms carried the genetic variation. Genetic testing in families affected by arrhythmogenic right ventricular cardiomyopathy helps to identify the genetic cause responsible for the disease. The incomplete penetrance and variable phenotypic expression highlights the need of comprehensive genetic analysis and further phenotype implications of genetics to clarify the pathophysiology of the disease. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  7. Automatic Evaluation and Uniform Filter Cascades for Inducing N-Best Translation Lexicons

    Melamed, I D


    This paper shows how to induce an N-best translation lexicon from a bilingual text corpus using statistical properties of the corpus together with four external knowledge sources. The knowledge sources are cast as filters, so that any subset of them can be cascaded in a uniform framework. A new objective evaluation measure is used to compare the quality of lexicons induced with different filter cascades. The best filter cascades improve lexicon quality by up to 137% over the plain vanilla statistical method, and approach human performance. Drastically reducing the size of the training corpus has a much smaller impact on lexicon quality when these knowledge sources are used. This makes it practical to train on small hand-built corpora for language pairs where large bilingual corpora are unavailable. Moreover, three of the four filters prove useful even when used with large training corpora.

  8. Automatic sequences

    Haeseler, Friedrich


    Automatic sequences are sequences which are produced by a finite automaton. Although they are not random they may look as being random. They are complicated, in the sense of not being not ultimately periodic, they may look rather complicated, in the sense that it may not be easy to name the rule by which the sequence is generated, however there exists a rule which generates the sequence. The concept automatic sequences has special applications in algebra, number theory, finite automata and formal languages, combinatorics on words. The text deals with different aspects of automatic sequences, in particular:· a general introduction to automatic sequences· the basic (combinatorial) properties of automatic sequences· the algebraic approach to automatic sequences· geometric objects related to automatic sequences.

  9. Right ventricular cardiomyopathy meeting the arrhythmogenic right ventricular dysplasia revised criteria? Do not forget sarcoidosis

    Vasaturo, Sabina; Ploeg, David E.; Zeppenfeld, Katja; Veselic-Charvat, Maud [Leiden University Medical Center, Leiden (Netherlands); Buitrago, Guadalupe [Dept. of Radiology, Hospital General Universitario Gregorio Maranon, Madrid (Spain)


    A 53-year-old woman was referred for ventricular fibrillation with resuscitation. A CT-angiography showed signs of a right ventricular enlargement without obvious cause. A cardiac MRI demonstrated a dilated and hypokinetic right ventricle with extensive late gadolinium enhancement. Arrhythmogenic right ventricular dysplasia (ARVD) was suspected according to the {sup r}evised ARVD task force criteria{sup .} An endomyocardial biopsy was inconclusive. The patient developed purulent pericarditis after epicardial ablation therapy and died of toxic shock syndrome. The post-mortem pathologic examination demonstrated sarcoidosis involving the heart, lungs, and thyroid gland.

  10. Nationwide (Denmark) Study of Symptoms Preceding Sudden Death due to Arrhythmogenic Right Ventricular Cardiomyopathy

    Sadjadieh, Golnaz; Jabbari, Reza; Risgaard, Bjarke


    In this study, we investigated medical history and symptoms before death in all subjects aged 1 to 35 years who died a sudden cardiac death (SCD) from arrhythmogenic right ventricular cardiomyopathy (ARVC) in Denmark in the years 2000 to 2006. All deaths (n=6,629) in subjects aged 1 to 35 years...... in Denmark in the period 2000 to 2006 were included. A total of 16 cases of SCD due to ARVC were identified based on histopathologic examination. Information on medical history was retrieved from The National Patient Registry, general practitioners, and hospitals. Symptoms before death were compared with 2...

  11. Natural history of arrhythmogenic right ventricular cardiomyopathy in the boxer dog: a prospective study.

    Meurs, K M; Stern, J A; Reina-Doreste, Y; Spier, A W; Koplitz, S L; Baumwart, R D


    Boxer arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease that may result in sudden death or heart failure. To prospectively study the natural history of Boxer ARVC. 72 dogs (49 ARVC, 23 controls). Boxers >1 year of age were recruited for annual reevaluation. CONTROLS were defined as being ≥6 years of age and having right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion. Syncope occurs in approximately 1/3 of affected dogs; systolic dysfunction is uncommon. The prognosis in many affected dogs is good. Copyright © 2014 by the American College of Veterinary Internal Medicine.

  12. Abnormal atrial activation is common in patients with arrhythmogenic right ventricular cardiomyopathy

    Platonov, Pyotr G; Christensen, Alex H; Holmqvist, Fredrik;


    INTRODUCTION: Structural right atrial abnormalities have been described in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, little is known about electrocardiographic signs of atrial involvement in ARVC because no systematic studies have been conducted. METHODS: P......%, whereas 15 patients (37%) had atypical P-wave positive in all 3 leads (P right ventricular abnormality. CONCLUSIONS: Patients with ARVC commonly demonstrate deteriorated...... atrial activation expressed either as prolonged P-wave duration or abnormal P-wave morphology. The P-wave abnormalities were not secondary to right ventricular dilatation. These findings show that atrial involvement is common in ARVC and may represent yet another manifestation of the disease...

  13. Fast rate (≥ 250 beats/min) right ventricular burst stimulation is useful for ventricular tachycardia induction in arrhythmogenic right ventricular cardiomyopathy

    Ling-Min WU; Jing-Ru BAO; Yan YAO; Bing-Bo HOU; Li-Hui ZHENG; Shu ZHANG


    Background One of the major challenges in arrhythmogenic right ventricular cardiomyopathy (ARVC) ablation is ventricular tachy-cardia (VT) non-inducibility. The study aimed to assess whether fast rate (≥ 250 beats/min) right ventricular burst stimulation was useful for VT induction in patients with ARVC.Methods Ninety-one consecutive ARVC patients with clinical sustained VT that underwent electro-physiological study were enrolled. The stimulation protocol was implemented at both right ventricular apex and outflow tract as follows: Step A, up to double extra-stimuli; Step B, incremental stimulation with low rate (< 250 beats/min); Step C, burst stimulation with fast rate (≥ 250 beats/min); Step D, repeated all steps above with intravenous infusion of isoproterenol.Results A total of 76 patients had inducible VT (83.5%), among which 49 were induced by Step C, 15 were induced by Step B, 8 and 4 by Step A and D, respectively. Clinical VTs were induced in 60 patients (65.9%). Only two spontaneously ceased ventricular fibrillations were induced by Step C. Multivariate analysis showed that a narrower baseline QRS duration under sinus rhythm was independently associated with VT non-inducibility (OR: 1.1; 95% CI: 1.0–1.1;P = 0.019).ConclusionFast rate (≥ 250 beats/min) right ventricular burst stimulation provides a useful supplemental method for VT induction in ARVC patients.

  14. Arrhythmogenic remodelling of activation and repolarization in the failing human heart.

    Holzem, Katherine M; Efimov, Igor R


    Heart failure is a major cause of disability and death worldwide, and approximately half of heart failure-related deaths are sudden and presumably due to ventricular arrhythmias. Patients with heart failure have been shown to be at 6- to 9-fold increased risk of sudden cardiac death compared to the general population. (AHA. Heart Disease and Stroke Statistics-2003 Update. Heart and Stroke Facts. Dallas, TX: American Heart Association; 2002) Thus, electrophysiological remodelling associated with heart failure is a leading cause of disease mortality and has been a major investigational focus examined using many animal models of heart failure. While these studies have provided an important foundation for understanding the arrhythmogenic pathophysiology of heart failure, the need for corroborating studies conducted on human heart tissue has been increasingly recognized. Many human heart studies of conduction and repolarization remodelling have now been published and shed some light on important, potentially arrhythmogenic, changes in human heart failure. These studies are being conducted at multiple experimental scales from isolated cells to whole-tissue preparations and have provided insight into regulatory mechanisms such as decreased protein expression, alternative mRNA splicing of ion channel genes, and defective cellular trafficking. Further investigations of heart failure in the human myocardium will be essential for determining possible therapeutic targets to prevent arrhythmia in heart failure and for facilitating the translation of basic research findings to the clinical realm.

  15. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in the Pediatric Population Clinical Characterization and Comparison with Adult-Onset Disease

    Te Riele, Anneline S J M; James, Cynthia A.; Sawant, Abhishek C.; Bhonsale, Aditya; Groeneweg, Judith A.; Mast, Thomas P.; Murray, Brittney; Tichnell, Crystal; Dooijes, Dennis; Van Tintelen, J. Peter; Judge, Daniel P.; van der Heijden, Jeroen F.; Crosson, Jane; Hauer, Richard N W; Calkins, Hugh; Tandri, Harikrishna


    Objectives The aims of this study were to determine the clinical characteristics and outcomes of pediatric-onset arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to compare these with those of adult-onset ARVD/C. Background Improved early detection and increased awareness of AR

  16. Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients--disease-causing or innocent bystanders?

    Christensen, Alex Hørby; Benn, Marianne; Tybjærg-Hansen, Anne


    Objectives: Mutations in genes encoding desmosomal proteins have been linked to arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). We hypothesized that a Scandinavian ARVC/D population would have a different spectrum of plakophilin-2 (PKP2) mutations and that some of the reported...

  17. High interobserver variability in the assessment of epsilon waves : Implications for diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia

    Platonov, Pyotr G; Calkins, Hugh; Hauer, Richard N; Corrado, Domenico; Svendsen, Jesper H; Wichter, Thomas; Biernacka, Elżbieta Katarzyna; Saguner, Ardan M; Te Riele, Anneline S J M; Zareba, Wojciech


    BACKGROUND: Revision of the Task Force diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) has increased their sensitivity for the diagnosis of early and familial forms of the disease. The epsilon wave is a major diagnostic criterion in the context of ARVC/D, w

  18. Truncating Plakophilin-2 Mutations in Arrhythmogenic Cardiomyopathy Are Associated with Protein Haploinsufficiency in Both Myocardium and Epidermis

    Rasmussen, Torsten Bloch; Nissen, Peter H; Palmfeldt, Johan


    BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac condition associated with ventricular arrhythmias, heart failure, and sudden death. The disease is most often caused by mutations in the desmosomal gene for plakophilin-2 (PKP2), which is expressed in both myocardial and epide...

  19. MRI for arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C); MRT bei arrhythmogener rechtsventrikulaerer Dysplasie/Kardiomyopathie (ARVD/C)

    Hunold, P. [Universitaetsklinikum Schleswig-Holstein, Campus Luebeck, Klinik fuer Radiologie und Nuklearmedizin, Luebeck (Germany)


    Arrhythmogenic right ventricular dysplasia/cardiomyopathy is a congenital disease that may present with sudden cardiac death as the first manifestation. Standards for the difficult clinical diagnosis are the so-called modified Task Force criteria that incorporate imaging-based, electrocardiographic and anamnestic information. Cardiac magnetic resonance imaging (MRI) is the standard technique for imaging of the right ventricle and can compliment the recent ARVD/C diagnosis criteria by providing exact information on right ventricular size and function. It is the most reliable modality available for the detection of right ventricular aneurysms and the quantification of ventricular size. Furthermore, MRI is able to identify areas of fatty or fibrous replacement within the right ventricular myocardium in a non-invasive way. However, a suspicion of ARVD/C cannot be confirmed or excluded based on MRI findings alone. In clinical routine cardiac MRI is an enormously important component in the ARVD/C diagnostic toolbox; however, MRI can only act as one part of the diagnostic puzzle and should exclusively be performed by experienced centers using specifically tailored protocols. (orig.) [German] Die arrhythmogene rechtsventrikulaere Dysplasie/Kardiomyopathie (ARVD/C) ist eine angeborene Erkrankung, deren Erstmanifestation haeufig der ploetzliche Herztod ist. Standard fuer die schwierige Diagnostik sind die sog. modifizierten Task-force-Kriterien, in die bildgebende, elektrokardiographische und anamnestische Befunde eingehen. Die MRT ist das Standardverfahren zur Darstellung des rechten Ventrikels. Zu den derzeit gueltigen ARVD/C-Diagnosekriterien kann die MRT exakte Informationen zu Groesse und Funktion des rechten Ventrikels liefern. Fuer die Identifizierung rechtsventrikulaerer Aneurysmata und zur Quantifizierung der Ventrikelgroesse ist die MRT die zuverlaessigste verfuegbare Methode. Darueber hinaus koennen Fibrose- und Fettareale innerhalb des rechtsventrikulaeren

  20. Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia.

    Corrado, Domenico


    The role of implantable cardioverter-defibrillator (ICD) in patients with arrhythmogenic right ventricular cardiomyopathy\\/dysplasia and no prior ventricular fibrillation (VF) or sustained ventricular tachycardia is an unsolved issue.

  1. "Repaired" tetralogy of fallot mimicking arrhythmogenic right ventricular cardiomyopathy (another phenocopy).

    George, Betsy Ann; Ko, Jong Mi; Lensing, Forrester Dubus; Kuiper, Johannes Jacob; Roberts, William Clifford


    Described is a 41-year-old man who at age 6 had partial resection of an obstructed right ventricular outflow tract with insertion of a patch and closure of a ventricular septal defect (tetralogy of Fallot). At age 41, cardiac transplantation was performed because of right ventricular outflow patch aneurysm, numerous episodes of ventricular tachycardia, and chronic heart failure, all features of the familial form of arrhythmogenic right ventricular cardiomyopathy (ARVC). Additionally, the patient had bundle branch block and epsilon waves on electrocardiogram, other features of ARVC. The case is described to introduce the concept of acquired ARVC, because the patient had many of the clinically recognized features of familial ARVC. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

    Sabir, Ian N; Li, Lucia M; Grace, Andrew A; Huang, Christopher L-H


    Alternans and arrhythmogenicity were studied in hypokalaemic (3.0 mM K(+)) Langendorff-perfused murine hearts paced at high rates. Epicardial and endocardial monophasic action potentials were recorded and durations quantified at 90% repolarization. Alternans and arrhythmia occurred in hypokalaemic, but not normokalaemic (5.2 mM K(+)) hearts (Plidocaine (10 microM, Plidocaine was associated with decreased slopes. Thus, hypokalaemia significantly increased (Plidocaine had no significant effect (P>0.05) on either maximal gradients (0.78+/-0.27 in the epicardium and 0.83+/-0.45 in the endocardium) or critical DIs (6.06+/-2.10 ms and 7.04+/-3.82 ms in the endocardium), treatment of hypokalaemic hearts with lidocaine reduced (Pmechanism and that these phenomena are abolished by lidocaine, both recapitulating and clarifying clinical findings.

  3. Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia:Proposed Modification of the Task Force Criteria



    @@ The original 1994 International Task Force criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC / D) were based on structural,histological,ECG,arrhythmic,and familial features of the disease (Table 1).Abnormalities were subdivided into major and minor categories according to the specificity of their association with ARVC / D.Right precordial T-wave inversion,though well recognized in ARVC / D,was considered a minor criterion because of its presence in other conditions,including anterior ischemia and right ventricular (RV) hypertrophy.Arrhythmias of RV origin,another cardinal feature of ARVC / D,was designated a minor criterion because of its occurrence in other diseases,particularly idiopathic RV outflow tract tachycardia.

  4. Outflow tract segmental arrhythmogenic right ventricular cardiomyopathy in an English Bulldog.

    Santilli, Roberto A; Bontempi, Luigi V; Perego, Manuela; Fornai, Lara; Basso, Cristina


    A 5-year-old English Bulldog was presented for acute onset of syncope and fatigue caused by sustained ventricular tachycardia with left bundle block morphology and inferior axis. This arrhythmia had the electrocardiographic features of a ventricular tachycardia arising from the right ventricular outflow tract (RVOT), as described in an experimental canine model and in people. Since a RVOT aneurysm was identified by echocardiography, a segmental form of arrhythmogenic right ventricular cardiomyopathy (ARVC) was suspected. Gross examination of the heart confirmed the bulging of the RVOT and histological examination of the ventricular myocardium revealed segmental involvement of the RVOT with transmural fibro-fatty degeneration. To the authors' knowledge, this is the first reported case of AVRC in an English Bulldog and the first example of segmental AVRC described in the dog.

  5. [Arrhythmogenic right ventricular cardiomyopathy/dysplasia. Literature review and case report].

    Camargo-Ariza, William Alejandro; Galvis-Blanco, Silvia Juliana; Camacho-Enciso, Tatiana Del Pilar; Quiroz-Romero, Carlos Alberto; Bermudez-Echeverry, Juan José


    Arrhythmogenic right ventricular cardiomyopathy/dysplasia is an inherited autosomal dominant pathology with an estimated prevalence of 1:2,500 to 1:5,000, being higher in males (3:1). It is characterized histologically by replacement of cardiomyocytes by fibro-adipose tissue, which predisposes to ventricular arrhythmias, right ventricular failure, and sudden cardiac death. The main goal of treatment is to reduce the risk of sudden death and improve the quality of life of patients. We present the case of a 23 year old woman whose clinical symptoms started with palpitations, chest pain with physical activity, syncope and headache 6 years ago during her first pregnancy. Due to an increase in symptomatology, a stress test was performed, during which she presented collapsing, sustained monomorphic ventricular tachycardia. A cardiac magnetic resonance showed dilatation, increase in trabeculae and decreased function of the right ventricle. A 3-dimentional mapping and ablation was performed and during the isoproterenol infusion test, a polymorphic ventricular flutter was generated requiring electrical cardioversion. The decision was made to implant a dual chamber cardioverter defibrillator and perform stellate ganglion ablation as secondary prevention. After her discharge, the patient reconsulted multiple times due to discharges of the device associated with palpitations. A comprehensive review of the patient's medical records was performed, finding characteristics that may suggest arrhythmogenic right ventricular dysplasia, the Task Force criteria was applied, concluding that because she met more than 2 major criteria, the patient had a definitive diagnosis of this disease. Copyright © 2017 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.

  6. The Different Substrate Characteristics of Arrhythmogenic Triggers in Idiopathic Right Ventricular Outflow Tract Tachycardia and Arrhythmogenic Right Ventricular Dysplasia: New Insight from Noncontact Mapping.

    Van Buu Dan Do

    Full Text Available The aim of this study was to investigate the different substrate characteristics of repetitive premature ventricular complexed (PVC trigger sites by the non-contact mapping (NCM.Thirty-five consecutive patients, including 14 with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC and 21 with idiopathic right ventricular outflow tract tachycardia (RVOT VT, were enrolled for electrophysiological study and catheter ablation guided by the NCM. Substrate and electrogram (Eg characteristics of the earliest activation (EA and breakout (BO sites of PVCs were investigated, and these were confirmed by successful PVC elimination.Overall 35 dominant focal PVCs were identified. PVCs arose from the focal origins with preferential conduction, breakout, and spread to the whole right ventricle. The conduction time and distance from EA to BO site were both longer in the ARVC than the RVOT group. The conduction velocity was similar between the 2 groups. The negative deflection of local unipolar Eg at the EA site (EA slope3,5,10ms values was steeper in the RVOT, compared to ARVC patients. The PVCs of ARVC occurred in the diseased substrate in the ARVC patients. More radiofrequency applications were required to eliminate the triggers in ARVC patients.The substrate characteristics of PVC trigger may help to differentiate between idiopathic RVOT VT and ARVC. The slowing and slurred QS unipolar electrograms and longer distance from EA to BO in RVOT endocardium suggest that the triggers of ARVC may originate from mid- or sub-epicardial myocardium. More extensive ablation to the trigger site was required in order to create deeper lesions for a successful outcome.

  7. Automatic Reading



    <正>Reading is the key to school success and,like any skill,it takes practice.A child learns to walk by practising until he no longer has to think about how to put one foot in front of the other.The great athlete practises until he can play quickly,accurately and without thinking.Ed- ucators call it automaticity.

  8. Cavopulmonary Anastomosis in a Patient With Arrhythmogenic Right Ventricular Cardiomyopathy With Severe Right Ventricular Dysfunction.

    Vaidyanathan, Swaminathan; Kothandam, Sivakumar; Kumar, Rajesh; Indrajith, Sujatha Desai; Agarwal, Ravi


    A 26-year-old lady presented with exertional dyspnea, palpitations, central cyanosis, and oxygen saturations of 80% in room air. Her electrocardiogram, echocardiogram, and cardiac magnetic resonance were diagnostic of arrhythmogenic right ventricular dysplasia. There was no documented ventricular arrhythmia or syncopal episodes and Holter recordings were repeatedly normal. Cardiac hemodynamics showed right to left shunt through atrial septal defect, low pulmonary blood flow, normal atrial pressures, and minimally elevated right ventricular end-diastolic pressures. Since her presenting symptoms and cyanosis were attributed to reduced pulmonary blood flow, she underwent off-pump cavopulmonary anastomosis between right superior vena cava and right pulmonary artery. As we intended to avoid the adverse effect of extracorporeal circulation on the myocardial function and pulmonary vasculature, we did not attempt to reduce the size of the atrial septal defect. Her postoperative period was uneventful; oxygen saturation improved to 89% with significant improvement in effort tolerance. At 18-month follow-up, there were no ventricular arrhythmias on surveillance. The clinical presentation of this disease may vary from serious arrhythmias warranting defibrillators and electrical ablations at one end to right ventricular pump failure warranting cardiomyoplasty or right ventricular exclusion procedures at the other end. However, when the presentation was unusual with severe cyanosis through a stretched foramen ovale leading to reduced pulmonary blood flows, Glenn shunt served as a good palliation and should be considered as one of the options in such patients.

  9. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

    Chelko, Stephen P; Asimaki, Angeliki; Andersen, Peter; Bedja, Djahida; Amat-Alarcon, Nuria; DeMazumder, Deeptankar; Jasti, Ravirasmi; MacRae, Calum A; Leber, Remo; Kleber, Andre G; Saffitz, Jeffrey E; Judge, Daniel P


    Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 prevents myocyte injury and cardiac dysfunction in vivo in two murine models of ACM at baseline and in response to exercise. SB2-treated mice with desmosome mutations showed improvements in ventricular ectopy and myocardial fibrosis/inflammation as compared with vehicle-treated (Veh-treated) mice. GSK3β inhibition improved left ventricle function and survival in sedentary and exercised Dsg2(mut/mut) mice compared with Veh-treated Dsg2(mut/mut) mice and normalized intercalated disc (ID) protein distribution in both mutant mice. GSK3β showed diffuse cytoplasmic localization in control myocytes but ID redistribution in ACM mice. Identical GSK3β redistribution is present in ACM patient myocardium but not in normal hearts or other cardiomyopathies. SB2 reduced total GSK3β protein levels but not phosphorylated Ser 9-GSK3β in ACM mice. Constitutively active GSK3β worsens ACM in mutant mice, while GSK3β shRNA silencing in ACM cardiomyocytes prevents abnormal ID protein distribution. These results highlight a central role for GSKβ in the complex phenotype of ACM and provide further evidence that pharmacologic GSKβ inhibition improves cardiomyopathies due to desmosome mutations.

  10. Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

    CHEN Xinshan; ZHANG Yigu; RAO Guangxun; HUANG Guangzhao


    Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a kind of primary myocardial disease characterized by the regional or global replacement of right ventricular myocardium by fatty and fibrolipomatous tissues.The ARVC,usually presenting with difrerent clinical manifestations and pathological changes,were mainly seen in young men and is one of the main causes of sudden death in the young.Here two autopsied cases of Chinese men aged 30 and 23 years old who appeared healthy but died suddenly while at work arc reported respectively.One of the victims had extensive and severe pathological changes in his heart involving the left ventricular wall as well as the ventricular septum and the right atrium.Not only was there a global fatty and fibrolipomatous tissue replacement of the right ventricular myocardia,but also mild sarcoplasmic coagulation in the myocardium and focal lymphocytic infiltration in the myocardial interstitium of the right ventricular wall.In addition,slight atherosclerosis of the coronary artery and intimal thickening of the sino-atrial node were observed.It is believed that there are no marked differences in the pathological changes of ARVC between Chinese patients and patients from western countries.The etiology and pathogenesis of ARVC could not be explained by a single cause or factor and they are probably related to various congenital and acquired causes or factors.

  11. De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy.

    Klauke, Baerbel; Kossmann, Sabine; Gaertner, Anna; Brand, Kristina; Stork, Ines; Brodehl, Andreas; Dieding, Mareike; Walhorn, Volker; Anselmetti, Dario; Gerdes, Désirée; Bohms, Birte; Schulz, Uwe; Zu Knyphausen, Edzard; Vorgerd, Matthias; Gummert, Jan; Milting, Hendrik


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease, frequently accompanied by sudden cardiac death and terminal heart failure. Genotyping of ARVC patients might be used for palliative treatment of the affected family. We genotyped a cohort of 22 ARVC patients referred to molecular genetic screening in our heart center for mutations in the desmosomal candidate genes JUP, DSG2, DSC2, DSP and PKP2 known to be associated with ARVC. In 43% of the cohort, we found disease-associated sequence variants. In addition, we screened for desmin mutations and found a novel desmin-mutation p.N116S in a patient with ARVC and terminal heart failure, which is located in segment 1A of the desmin rod domain. The mutation leads to the aggresome formation in cardiac and skeletal muscle without signs of an overt clinical myopathy. Cardiac aggresomes appear to be prominent, especially in the right ventricle of the heart. Viscosimetry and atomic force microscopy of the desmin wild-type and N116S mutant isolated from recombinant Escherichia coli revealed severe impairment of the filament formation, which was supported by transfections in SW13 cells. Thus, the gene coding for desmin appears to be a novel ARVC gene, which should be included in molecular genetic screening of ARVC patients.

  12. Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy.

    Brun, Francesca; Barnes, Carl V; Sinagra, Gianfranco; Slavov, Dobromir; Barbati, Giulia; Zhu, Xiao; Graw, Sharon L; Spezzacatene, Anita; Pinamonti, Bruno; Merlo, Marco; Salcedo, Ernesto E; Sauer, William H; Taylor, Matthew R G; Mestroni, Luisa


    Genotype-phenotype correlations are poorly characterised in arrhythmogenic right ventricular cardiomyopathy (ARVC). We investigated whether carriers of rare variants in desmosomal genes (DC) and titin gene (TTN) display different phenotypes and clinical outcomes compared with non-carriers (NT-ND). Thirty-nine ARVC families (173 subjects, 67 affected) with extensive follow-up (mean 9 years), prospectively enrolled in the International Familial Cardiomyopathy Registry since 1991, were screened for rare variants in TTN and desmosomal genes (DSP, PKP2, DSG2, DSC2). Multiple clinical and outcome variables were compared between three genetic groups (TTN, DC, NT-ND) to define genotype-phenotype associations. Of the 39 ARVC families, 13% (5/39) carried TTN rare variants (11 affected subjects), 13% (5/39) DC (8 affected), while 74% (29/39) were NT-ND (48 affected). When compared with NT-ND, DC had a higher prevalence of inverted T waves in V2-3 (75% vs 31%, p=0.004), while TTN had more supraventricular arrhythmias (46% vs 13%, p=0.013) and conduction disease (64% vs 6% prights-licensing/permissions.

  13. [MRI and arrhythmogenic right ventricular dysplasia (ARVD). Retrospective evaluation of 50 patients].

    Dumousset, E; Alfidja, A; Lamaison, D; Ponsonnaille, J; Ravel, A; Garcier, J M; Boyer, L


    To retrospectively evaluate the contribution of MRI to the diagnosis of arrhythmogenic right ventricular dysplasia (ARVD). Thirty two men and 18 women (mean age: 48.7 years) were imaged using gated spin echo scans and short axis cine MR. References were McKenna criteria (gold standard), and also what we called "strong presumption" which may correspond to early or localized patterns, but correspond to negative McKenna scores. One patient was claustrophobic; another one was lost to follow-up. In reference to McKenna score, diagnosis of ARVD was established in 12 patients (2 of whom had familial dilated biventricular cardiomyopathy with rhythmic expression). Sensitivity, specificity, positive predictive value, negative predictive value and prevalence were respectively: 75%, 75%, 50%, 90% and 25%. Using "strong presumption" criteria, we observed 14 true positives (with sensitivity of 82%, specificity of 87%, PPV of 78%, NPV of 90% and prevalence of 35%). In our group, MRI was always performed before angiography. In our series, right ventricular wall T1W hyperintensity was the most frequent finding.

  14. Arrhythmogenic right ventricular cardiomyopathy: From genetics to diagnostic and therapeutic challenges

    Bruno; Pinamonti; Francesca; Brun; Luisa; Mestroni; Gianfranco; Sinagra


    Arrhythmogenic right ventricular cardiomyopathy(ARVC) is a genetic disease characterized by myocyte loss and fibro-fatty tissue replacement. Diagnosis of ARVC remains a clinical challenge mainly at its early stages and in patients with minimal echocardiographic right ventricular(RV) abnormalities. ARVC shares some common features with other cardiac diseases, such as RV outflow ventricular tachycardia, Brugada syndrome, and myocarditis, due to arrhythmic expressivity and biventricular involvement. The identification of ARVC can be often challenging, because of the heterogeneous clinical presentation, highly variable intra- and inter-family expressivity and incomplete penetrance. This genotypephenotype “plasticity” is largely unexplained. A familial history of ARVC is present in 30% to 50% of cases, and the disease is considered a genetic cardiomyopathy, usually inherited in an autosomal dominant pattern with variable penetrance and expressivity; in addition, autosomal recessive forms have been reported(Naxos disease and Carvajal syndrome). Diagnosis of ARVC relays on a scoring system, with major or minorcriteria on the Revised Task Force Criteria. Implantable cardioverter defibrillators(ICDs) are increasingly utilized in patients with ARVC who have survived sudden death(SD)(secondary prevention). However, there are few data available to help identifying ARVC patients in whom the prophylactic implantation of an ICD is truly warranted. Prevention of SD is the primary goal of management. Pharmacologic treatment of arrhythmias, catheter ablation of ventricular tachycardia, and ICD are the mainstay of treatment of ARVC.

  15. Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy.

    Li Mura, Ilena Egle Astrid; Bauce, Barbara; Nava, Andrea; Fanciulli, Manuela; Vazza, Giovanni; Mazzotti, Elisa; Rigato, Ilaria; De Bortoli, Marzia; Beffagna, Giorgia; Lorenzon, Alessandra; Calore, Martina; Dazzo, Emanuela; Nobile, Carlo; Mostacciuolo, Maria Luisa; Corrado, Domenico; Basso, Cristina; Daliento, Luciano; Thiene, Gaetano; Rampazzo, Alessandra


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle disease characterized by progressive myocardial loss, with fibro-fatty replacement, and high frequency of ventricular arrhythmias that can lead to sudden cardiac death. ARVC is a genetically determined disorder, usually caused by point mutations in components of the cardiac desmosome. Conventional mutation screening of ARVC genes fails to detect causative mutations in about 50% of index cases, suggesting a further genetic heterogeneity. We performed a genome-wide linkage study and a copy number variations (CNVs) analysis, using high-density SNP arrays, in an ARVC family showing no mutations in any of the desmosomal genes. The CNVs analysis identified a heterozygous deletion of about 122 kb on chromosome 12p11.21, including the entire plakophilin-2 gene and shared by all affected family members. It was not listed on any of available public CNVs databases and was confirmed by quantitative real-time PCR. This is the first SNP array-based genome-wide study leading to the identification of a CNV segregating with the disease phenotype in an ARVC family. This result underscores the importance of performing additional analysis for possible genomic deletions/duplications in ARVC patients without point mutations in known disease genes.

  16. Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium.

    Grant, A O; Hondeghem, L M; Katzung, B G


    The neuroleptic drug droperidol has been shown to have clinically useful antiarrhythmic activity. Prior reports have resulted in conflicting conclusions regarding actions on ventricular myocardial fibers. The present study was carried out to determine whether droperidol did in fact affect the electrophysiological properties of guinea-pig papillary muscle fibers. By means of microelectrode recordings from preparations mounted in a single sucrose gap, the effects of concentrations from 10(-6) to 4 X 10(-5) M were studied on depolarization-induced automaticity, and on Vmax and its recovery time under several conditions of membrane potential, stimulation rate and external ion concentration. The results showed that at clinically relevant concentrations, droperidol significantly slows ventricular pacemaker activity, a depression reversible by epinephrine. Furthermore, Vmax was decreased and the time constant for Vmax recovery was significantly prolonged under several conditions which pertain to clinical arrhythmias, i.e., reduced membrane potential, elevated extracellular potassium concentrations and increased stimulation rate.

  17. Seismic features and automatic discrimination of deep and shallow induced-microearthquakes using neural network and logistic regression

    Mousavi, S. Mostafa; Horton, Stephen, P.; Langston, Charles A.; Samei, Borhan


    We develop an automated strategy for discriminating deep microseismic events from shallow ones on the basis of the waveforms recorded on a limited number of surface receivers. Machine-learning techniques are employed to explore the relationship between event hypocenters and seismic features of the recorded signals in time, frequency, and time-frequency domains. We applied the technique to 440 microearthquakes -1.7deep and shallow events based on the knowledge gained from existing patterns. The cross validation test showed that events with depth shallower than 250 m can be discriminated from events with hypocentral depth between 1000 to 2000 m with 88% and 90.7% accuracy using logistic regression (LR) and artificial neural network (ANN) models, respectively. Similar results were obtained using single station seismograms. The results show that the spectral features have the highest correlation to source depth. Spectral centroids and 2D cross-correlations in the time-frequency domain are two new seismic features used in this study that showed to be promising measures for seismic event classification. The used machine learning techniques have application for efficient automatic classification of low energy signals recorded at one or more seismic stations.

  18. Progress towards an unassisted element identification from Laser Induced Breakdown Spectra with automatic ranking techniques inspired by text retrieval

    Amato, G.; Cristoforetti, G.; Legnaioli, S.; Lorenzetti, G.; Palleschi, V.; Sorrentino, F.; Tognoni, E.


    In this communication, we will illustrate an algorithm for automatic element identification in LIBS spectra which takes inspiration from the vector space model applied to text retrieval techniques. The vector space model prescribes that text documents and text queries are represented as vectors of weighted terms (words). Document ranking, with respect to relevance to a query, is obtained by comparing the vectors representing the documents with the vector representing the query. In our case, we represent elements and samples as vectors of weighted peaks, obtained from their spectra. The likelihood of the presence of an element in a sample is computed by comparing the corresponding vectors of weighted peaks. The weight of a peak is proportional to its intensity and to the inverse of the number of peaks, in the database, in its wavelength neighboring. We suppose to have a database containing the peaks of all elements we want to recognize, where each peak is represented by a wavelength and it is associated with its expected relative intensity and the corresponding element. Detection of elements in a sample is obtained by ranking the elements according to the distance of the associated vectors from the vector representing the sample. The application of this approach to elements identification using LIBS spectra obtained from several kinds of metallic alloys will be also illustrated. The possible extension of this technique towards an algorithm for fully automated LIBS analysis will be discussed.

  19. Seismic features and automatic discrimination of deep and shallow induced-microearthquakes using neural network and logistic regression

    Mousavi, S. Mostafa; Horton, Stephen P.; Langston, Charles A.; Samei, Borhan


    We develop an automated strategy for discriminating deep microseismic events from shallow ones on the basis of the waveforms recorded on a limited number of surface receivers. Machine-learning techniques are employed to explore the relationship between event hypocentres and seismic features of the recorded signals in time, frequency and time-frequency domains. We applied the technique to 440 microearthquakes -1.7 train the system to discriminate between deep and shallow events based on the knowledge gained from existing patterns. The cross-validation test showed that events with depth shallower than 250 m can be discriminated from events with hypocentral depth between 1000 and 2000 m with 88 per cent and 90.7 per cent accuracy using logistic regression and artificial neural network models, respectively. Similar results were obtained using single station seismograms. The results show that the spectral features have the highest correlation to source depth. Spectral centroids and 2-D cross-correlations in the time-frequency domain are two new seismic features used in this study that showed to be promising measures for seismic event classification. The used machine-learning techniques have application for efficient automatic classification of low energy signals recorded at one or more seismic stations.

  20. Progress towards an unassisted element identification from Laser Induced Breakdown Spectra with automatic ranking techniques inspired by text retrieval

    Amato, G. [ISTI-CNR, Area della Ricerca, Via Moruzzi 1, 56124, Pisa (Italy); Cristoforetti, G.; Legnaioli, S.; Lorenzetti, G.; Palleschi, V. [IPCF-CNR, Area della Ricerca, Via Moruzzi 1, 56124, Pisa (Italy); Sorrentino, F., E-mail: sorrentino@fi.infn.i [Dipartimento di Fisica e astronomia, Universita di Firenze, Polo Scientifico, via Sansone 1, 50019 Sesto Fiorentino (Italy); Istituto di Cibernetica CNR, via Campi Flegrei 34, 80078 Pozzuoli (Italy); Marwan Technology, c/o Dipartimento di Fisica ' E. Fermi' , Largo Pontecorvo 3, 56127 Pisa (Italy); Tognoni, E. [INO-CNR, Area della Ricerca, Via Moruzzi 1, 56124 Pisa (Italy)


    In this communication, we will illustrate an algorithm for automatic element identification in LIBS spectra which takes inspiration from the vector space model applied to text retrieval techniques. The vector space model prescribes that text documents and text queries are represented as vectors of weighted terms (words). Document ranking, with respect to relevance to a query, is obtained by comparing the vectors representing the documents with the vector representing the query. In our case, we represent elements and samples as vectors of weighted peaks, obtained from their spectra. The likelihood of the presence of an element in a sample is computed by comparing the corresponding vectors of weighted peaks. The weight of a peak is proportional to its intensity and to the inverse of the number of peaks, in the database, in its wavelength neighboring. We suppose to have a database containing the peaks of all elements we want to recognize, where each peak is represented by a wavelength and it is associated with its expected relative intensity and the corresponding element. Detection of elements in a sample is obtained by ranking the elements according to the distance of the associated vectors from the vector representing the sample. The application of this approach to elements identification using LIBS spectra obtained from several kinds of metallic alloys will be also illustrated. The possible extension of this technique towards an algorithm for fully automated LIBS analysis will be discussed.

  1. Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

    Lombardi, Raffaella; Dong, Jinjiang; Rodriguez, Gabriela; Bell, Achim; Leung, Tack Ki; Schwartz, Robert J.; Willerson, James T.; Brugada, Ramon; Marian, Ali J.


    The phenotypic hallmark of arrhythmogenic right ventricular cardiomyopathy, a genetic disease of desmosomal proteins, is fibroadipocytic replacement of the right ventricle. Cellular origin of excess adipocytes, the responsible mechanism(s) and the basis for predominant involvement of the right ventricle are unknown. We generated 3 sets of lineage tracer mice regulated by cardiac lineage promoters α-myosin heavy chain (αMyHC), Nkx2.5, or Mef2C. We conditionally expressed the reporter enhanced yellow fluorescent protein while concomitantly deleting the desmosomal protein desmoplakin in cardiac myocyte lineages using the Cre-LoxP technique. Lineage tracer mice showed excess fibroadiposis and increased numbers of adipocytes in the hearts. Few adipocytes in the hearts of αMyHC-regulated lineage tracer mice, but the majority of adipocytes in the hearts of Nkx2.5- and Mef2C-regulated lineage tracer mice, expressed enhanced yellow fluorescent protein. In addition, rare cells coexpressed adipogenic transcription factors and the second heart field markers Isl1 and Mef2C in the lineage tracer mouse hearts and in human myocardium from patients with arrhythmogenic right ventricular cardiomyopathy. To delineate the responsible mechanism, we generated transgenic mice expressing desmosomal protein plakoglobin in myocyte lineages. Transgene plakoglobin translocated to nucleus, detected by immunoblotting and immunofluorescence staining and coimmunoprecipitated with Tcf7l2, a canonical Wnt signaling transcription factor. Expression levels of canonical Wnt/Tcf7l2 targets bone morphogenetic protein 7 and Wnt5b, which promote adipogenesis, were increased and expression level of connective tissue growth factor, an inhibitor of adipogenesis, was decreased. We conclude adipocytes in arrhythmogenic right ventricular cardiomyopathy originate from the second heart field cardiac progenitors, which switch to an adipogenic fate because of suppressed canonical Wnt signaling by nuclear

  2. Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada

    Haywood, Annika


    AimsAutosomal dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) (in the group of arrhythmogenic cardiomyopathies) is a common cause of sudden cardiac death in young adults. It is both clinically and genetically heterogeneous, with 12 loci (ARVC/D1-12) and eight genes identified, the majority of which encode structural proteins of cardiac desmosomes. The most recent gene identified, TMEM43, causes disease due to a missense mutation in a non-desmosomal gene (p.S358L) in 15 extended families from Newfoundland, Canada. To determine whether mutations in TMEM43 cause ARVC/D and arrhythmogenic cardiomyopathy in other populations, we fully re-sequenced TMEM43 on 143 ARVC/D probands (families) from the UK and 55 probands (from 55 families) from Newfoundland.Methods and resultsBidirectional sequencing of TMEM43 including intron-exon boundaries revealed 33 variants, the majority located in non-coding regions of TMEM43. For the purpose of validation, families of probands with rare, potentially deleterious coding variants were subjected to clinical and molecular follow-up. Three missense variants of uncertain significance (p.R28W, p.E142K, p.R312W) were located in highly conserved regions of the TMEM43 protein. One variant (p.R312W) also co-segregated with relatives showing clinical signs of disease. Genotyping and expansion of the disease-associated haplotype in subjects with the p.R312W variant from Newfoundland, Canada, and the UK suggest common ancestry.ConclusionAlthough the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation. © 2012 The Author.

  3. Truncating plakophilin-2 mutations in arrhythmogenic cardiomyopathy are associated with protein haploinsufficiency in both myocardium and epidermis

    Rasmussen, Torsten B; Nissen, Peter H; Palmfeldt, Johan;


    BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac condition associated with ventricular arrhythmias, heart failure, and sudden death. The disease is most often caused by mutations in the desmosomal gene for plakophilin-2 (PKP2), which is expressed in both myocardial...... individuals. It was evident that PKP2 mutations introducing a premature termination codon in the reading frame were associated with PKP2 transcript and protein levels reduced to ≈50%, whereas a missense variant did not seem to affect the amount of PKP2 protein. CONCLUSIONS: The results of this study showed...

  4. Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts.

    Alexia Vite

    Full Text Available AIMS: Arrhythmogenic right ventricular Dysplasia/cardiomyopathy (ARVD/C is an autosomal dominant inherited cardiomyopathy associated with ventricular arrhythmia, heart failure and sudden death. Genetic studies have demonstrated the central role of desmosomal proteins in this disease, where 50% of patients harbor a mutation in a desmosmal gene. However, clinical diagnosis of the disease remains difficult and molecular mechanisms appears heterogeneous and poorly understood. The aim of this study was to characterize the expression profile of desmosomal proteins in explanted ARVD/C heart samples, in order to identify common features of the disease. METHODS AND RESULTS: We examined plakophilin-2, desmoglein-2, desmocollin-2, plakoglobin and β-catenin protein expression levels from seven independent ARVD/C heart samples compared to two ischemic, five dilated cardiomyopathy and one healthy heart sample as controls. Ventricular and septum sections were examined by immunoblot analysis of total heart protein extracts and by immunostaining. Immunoblots indicated significant decreases in desmoglein-2 and desmocollin-2, independent of any known underlying mutations, whereas immune-histochemical analysis showed normal localization of all desmosomal proteins. Quantitative RT-PCR revealed normal DSG2 and DSC2 mRNA transcript levels, suggesting increased protein turn-over rather than transcriptional down regulation. CONCLUSION: Reduced cardiac desmoglein-2 and desmocollin-2 levels appear to be specifically associated with ARVD/C, independent of underlying mutations. These findings highlight a key role of desmosomal cadherins in the pathophysiology of ARVD/C. Whether these reductions could be considered as specific markers for ARVD/C requires replication analysis.

  5. In vitro functional analyses of arrhythmogenic right ventricular cardiomyopathy-associated desmoglein-2-missense variations.

    Anna Gaertner

    Full Text Available BACKGROUND: Although numerous sequence variants in desmoglein-2 (DSG2 have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC, the functional impact of new sequence variations is difficult to estimate. METHODOLOGY/PRINCIPAL FINDINGS: To test the functional consequences of DSG2-variants, we established an expression system for the extracellular domain and the full-length DSG2 using the human cell line HT1080. We established new tools to investigate ARVC-associated DSG2 variations and compared wild-type proteins and proteins with one of the five selected variations (DSG2-p.R46Q, -p.D154E, -p.D187G, -p.K294E, -p.V392I with respect to prodomain cleavage, adhesion properties and cellular localisation. CONCLUSIONS/SIGNIFICANCE: The ARVC-associated DSG2-p.R46Q variation was predicted to be probably damaging by bioinformatics tools and to concern a conserved proprotein convertase cleavage site. In this study an impaired prodomain cleavage and an influence on the DSG2-properties could be demonstrated for the R46Q-variant leading to the classification of the variant as a potential gain-of-function mutant. In contrast, the variants DSG2-p.K294E and -p.V392I, which have an arguable impact on ARVC pathogenesis and are predicted to be benign, did not show functional differences to the wild-type protein in our study. Notably, the variants DSG2-p.D154E and -p.D187G, which were predicted to be damaging by bioinformatics tools, had no detectable effects on the DSG2 protein properties in our study.

  6. In Vitro Functional Analyses of Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmoglein-2-Missense Variations

    Gaertner, Anna; Klauke, Baerbel; Stork, Ines; Niehaus, Karsten; Niemann, Gesa; Gummert, Jan; Milting, Hendrik


    Background Although numerous sequence variants in desmoglein-2 (DSG2) have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), the functional impact of new sequence variations is difficult to estimate. Methodology/Principal Findings To test the functional consequences of DSG2-variants, we established an expression system for the extracellular domain and the full-length DSG2 using the human cell line HT1080. We established new tools to investigate ARVC-associated DSG2 variations and compared wild-type proteins and proteins with one of the five selected variations (DSG2-p.R46Q, -p.D154E, -p.D187G, -p.K294E, -p.V392I) with respect to prodomain cleavage, adhesion properties and cellular localisation. Conclusions/Significance The ARVC-associated DSG2-p.R46Q variation was predicted to be probably damaging by bioinformatics tools and to concern a conserved proprotein convertase cleavage site. In this study an impaired prodomain cleavage and an influence on the DSG2-properties could be demonstrated for the R46Q-variant leading to the classification of the variant as a potential gain-of-function mutant. In contrast, the variants DSG2-p.K294E and -p.V392I, which have an arguable impact on ARVC pathogenesis and are predicted to be benign, did not show functional differences to the wild-type protein in our study. Notably, the variants DSG2-p.D154E and -p.D187G, which were predicted to be damaging by bioinformatics tools, had no detectable effects on the DSG2 protein properties in our study. PMID:23071725

  7. Differential expression of the cardiac ryanodine receptor in normal and arrhythmogenic right ventricular cardiomyopathy canine hearts.

    Meurs, Kathryn M; Lacombe, Veronique A; Dryburgh, Keith; Fox, Philip R; Reiser, Peter R; Kittleson, Mark D


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a form of cardiomyopathy characterized by ventricular tachyarrhythmias and a fibrofatty infiltrate that is believed to preferentially affect the right ventricle. Mutations in the cardiac ryanodine receptor (RyR2) gene have been identified in some human families with a unique form of ARVC, ARVC2. Although the RyR2 has significant importance in excitation-contraction coupling across the ventricles, mutations in the gene encoding for it appear to have the greatest impact on the right ventricle in ARVC2. Using a canine model (boxer), the RyR2 protein and message RNA in the right ventricle, left ventricle and interventricular septum from normal dogs and dogs with ARVC were investigated by immunoblotting and real time PCR. The cardiac RyR2 message and protein expression were differentially expressed across the cardiac walls in the normal heart, with the lowest concentration expressed in the right ventricle (P < 0.05). The message and protein expression of the RyR2 were reduced in all chambers in the canine model of ARVC. We propose that the increased susceptibility of the right ventricle to ARVC may be associated with the lower baseline protein concentration of RyR2 in the normal right ventricle compared to the left ventricle and interventricular septum and that all three areas are equally affected in this canine model of ARVC. Using this naturally occurring model of canine ARVC, we may have provided new insights into the pathogenesis of this cardiomyopathy.

  8. Natural history and risk stratification of arrhythmogenic right ventricular dysplasia/cardiomyopathy.

    Hulot, Jean-Sébastien; Jouven, Xavier; Empana, Jean-Philippe; Frank, Robert; Fontaine, Guy


    Management of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is complicated by the incomplete information on the natural history of the disease and by the lack of risk stratification for cardiovascular death. The aim of the study was the identification of risk factors related to long-term prognosis. Data were collected from 130 patients (100 men; age at onset of symptoms, 31.8+/-14.4 years) from a tertiary center between 1977 and 2000 who fulfilled the international standardized diagnostic criteria for ARVD/C. Risk factors for cardiovascular death were determined by a logistic regression model. After a mean follow-up of 8.1+/-7.8 years, 24 deaths were recorded, with a mean age at death of 54+/-19 years (annual mortality rate, 2.3%). There were 21 deaths with a cardiovascular origin (progressive heart failure for 14 patients and sudden death for the remaining 7 patients). All patients who died had a history of ventricular tachycardia. Multivariate analysis showed that after adjustment for sex, history of syncope, chest pain, inaugural ventricular tachycardia, recurrence of ventricular tachycardia, and QRS dispersion, clinical signs of right ventricular failure and left ventricular dysfunction both remained independently associated with cardiovascular mortality. The combined presence of one of these risk factors and ventricular tachycardia identifies high-risk subjects for cardiovascular mortality, whereas patients without ventricular tachycardia displayed the best prognosis. The information on the natural history of patients with ARVD allowed us to identify risks factors for cardiovascular mortality. An analysis of a large international registry is needed to refine these results.

  9. Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression.

    Sen-Chowdhry, Srijita


    According to clinical-pathological correlation studies, the natural history of arrhythmogenic right ventricular dysplasia\\/cardiomyopathy is purported to progress from localized to global right ventricular dysfunction, followed by left ventricular (LV) involvement and biventricular pump failure. The inevitable focus on sudden death victims and transplant recipients may, however, have created a skewed perspective of a genetic disease. We hypothesized that unbiased representation of the spectrum of disease expression in arrhythmogenic right ventricular dysplasia\\/cardiomyopathy would require in vivo assessment of families in a genetically heterogeneous population.

  10. Imaging Phenotype vs. Genotype in Non-Hypertrophic Heritable Cardiomyopathies: Dilated Cardiomyopathy and Arrhythmogenic Right Ventricular Cardiomyopathy

    Raman, Subha V.; Basso, Cristina; Tandri, Harikrishna; Taylor, Matthew R. G.


    Advances in cardiovascular imaging increasingly afford unique insights into heritable myocardial disease. As clinical presentation of genetic cardiomyopathies may range from nonspecific symptoms to sudden cardiac death, accurate diagnosis has implications for individual patients as well as related family members. The initial consideration of genetic cardiomyopathy may occur in the imaging laboratory, where one must recognize the patient with arrhythmogenic right ventricular cardiomyopathy (ARVC) among the many with ventricular arrhythmia referred to define myocardial substrate. Accurate diagnosis of the patient presenting with dyspnea and palpitations whose first-degree relatives have lamin A/C cardiomyopathy may warrant genetic testing1, 2 plus imaging of diastolic function and myocardial fibrosis3. As advances in cardiac imaging afford detection of subclinical structural and functional changes, the imaging specialist must be attuned to signatures of specific genetic disorders. With increased availability of both advanced imaging as well as genotyping techniques, this review seeks to provide cardiovascular imaging specialists and clinicians with the contemporary information needed for more precise diagnosis and treatment of heritable myocardial disease. A companion paper in this series covers imaging phenotype and genotype considerations in hypertrophic cardiomyopathy (HCM). This review details clinical features, imaging phenotype and current genetic understanding for two of the most common non-HCM conditions that prompt myocardial imaging - dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC). While all modalities are considered herein, considerable focus is given to CMR with its unique capabilities for myocardial tissue characterization. PMID:21081743

  11. Genome-wide association identifies a deletion in the 3’ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy

    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by rapid ventricular tachycardia and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression. Th...

  12. Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members

    Groeneweg, Judith A.; Bhonsale, Aditya; James, Cynthia A.; Te Riele, Anneline S.; Dooijes, Dennis; Tichnell, Crystal; Murray, Brittney; Wiesfeld, Ans C P; Sawant, Abhishek C.; Kassamali, Bina; Atsma, Douwe E.; Volders, Paul G.; De Groot, Natasja M.; De Boer, Karin; Zimmerman, Stefan L.; Kamel, Ihab R.; van der Heijden, JF; Russell, Stuart D.; Cramer, MJ; Tedford, Ryan J.; Doevendans, Pieter A.; van Veen, AAB; Tandri, Harikrishna; Wilde, Arthur A.; Judge, Daniel P.; Van Tintelen, J. Peter; Hauer, Richard N. W.; Calkins, Hugh


    Background Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a progressive cardiomyopathy. We aimed to define long-term outcome in a transatlantic cohort of 1001 individuals. Methods and Results Clinical and genetic characteristics and follow-up data of ARVD/C index-patients (n=4

  13. Clinical study of 39 Chinese patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy

    MA Ke-juan; LI Ning; WANG Hong-tao; CHU Jian-min; FANG Pi-hua; YAO Yan; MA Jian; HUA Wei; ZIIANG Shu; WANG Fang-zheng; Li Zhang; PU Jie-lin


    Background There are few studies on the clinical profile of Chinese patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). The purpose of this study was to describe the clinical characteristics of ARVD/C patients from China, particularly to define the features of electrocardiograph and treatment outcomes.Methods Thirty-nine patients hospitalized in Fu Wai Cardiovascular Hospital from 1998 to 2006 were included. The data were obtained from the medical archive and the follow-up records.Results Of these patients 33 were male and 6 female (age at the first presentation was (34.9±9.8) years). The most common symptoms were palpitation (62%) and syncope (44%). Right precordial QRSd ≥ 110 ms was detected in 69% of the patients, epsilon wave in 59%, and a ratio of QRSd in V1+V2+V3/V4+V5+V6 ≥ 1.2 in 82%. The most frequent features of electrocardiogram in patients without right bundle-branch block were T-wave inversions and S-wave upstroke in V1-V3 ≥55 ms (96% and 90% of 28 patients, respectively). Radiofrequency catheter ablation (RFCA) for ventricular tachycardia (VT) was successful in 15 (68%) of 22 patients. The recurrence rate of VT was 46% (7/15) during the follow-up of (16.7± 11.2) months. Seven patients had cardioverter/defibrillator (ICD) implanted plus drug therapy and 17 patients took antiarrhythmic drugs alone. During the follow-up of (35.6±19.0) months, all patients with ICD implanted received at least one appropriate ICD shock. One patient died of ventricular fibrillation suddenly and one patient underwent heart transplantation for progressive biventricular heart failure during the drug therapy alone.Conclusions This study demonstrated the clinical and ECG features of the 39 ARVD/C Chinese patients. ICD provided life-saving protection by effectively terminating malignant arrhythmias, and the high recurrence of VT was the major problem of RFCA therapy.

  14. Is cardiac MRI an effective test for arrhythmogenic right ventricular cardiomyopathy diagnosis?

    Santhi; Chellamuthu; Alyson; M; Smith; Steven; M; Thomas; Catherine; Hill; Peter; W; G; Brown; Abdallah; Al-Mohammad


    AIM:To evaluate the referrals with suspected arrhythmogenic right ventricular cardiomyopathy(ARVC)and compare cardiac MR(cMR)findings against clinical diagnosis.METHODS:A retrospective analysis of 114(age range16 to 83,males 55%and females 45%)patients referred for cMR with a suspected diagnosis of ARVC between May 2006 and February 2010 was performed after obtaining institutional approval for service evaluation.Reasons for referral including clinical symptoms and family history of sudden death,electrocardiogram and echo abnormalities,cMR findings,final clinical diagnosis and information about clinical management were obtained.The results of cMR were classified as major,minor,non-specific or negative depending on both functional and tissue characterisation and the cMR results were compared against the final clinical diagnosis.RESULTS:The most common reasons for referral included arrhythmias(30%)and a family history of sudden death(20%).Of the total cohort of 114 patients:4 patients(4%)had major cMR findings for ARVC,13patients(11%)had minor cMR findings,2 patients had non-specific cMR findings relating to the right ventricle and 95 patients had a negative cMR.Of the 4 patients who had major cMR findings,3(75%)had a positive clinical diagnosis.In contrast,of the 13 patients who had minor cMR findings,only 2(15%)had a positive clinical diagnosis.Out of the 95 negative patients,clinical details were available for 81 patients and none of them had ARVC.Excluding the 14 patients with no clinical data and final diagnosis,the sensitivity of the test was 100%,specificity 87%,positive predictive value29%and the negative predictive value 100%.CONCLUSION:CMR is a useful tool for ARVC evaluation because of the high negative predictive value as the outcome has a significant impact on the clinical decision-making.

  15. Linkage analysis of five Chinese families with arrhythmogenic right ventricular cardiomyopathy using microsatellite genetic markers

    黄峻; 杨春梅; 马立隽; 单其俊; 许迪; 华子春; 曹克将


    Objective To explore the linkage relationship between specific genetic markers and arrhythmogenic right ventricular cardiomyopathy (ARVC) in Chinese pedigrees.Methods The microsatellite genetic markers D2S152, D14S252, and D10S1664 were studied for their linkages to ARVC in five Chinese ARVC pedigrees and a normal population of 121 Chinese individuals. Genomic DNA of the pedigrees and normal population was amplified using PCR techniques. Denaturing polyacrylamide sequencing gel (4%) electrophoresis was used to detect microsatellite repeat polymorphisms. Gels were silver-stained. A classical linkage analysis program was used assuming models of autosomal dominance and recession. Results The logarithm of the odds (LOD) scores of D2S152 with ARVC in LW, WD, DS, LC and TY pedigrees were 2.174, -0.589, -∞, - (indicating that linkage is not supported in this mode), and -∞ respectively in autosomal dominant model (recombination fraction=0.000 respectively)and were -∞, -∞, -∞, -∞, and 0.182 respectively in the autosomal recessive model. The LOD scores of D14S252 with ARVC in LW, WD, DS, LC and TY pedigrees were -, -, -∞, -, and 0 respectively in autosomal dominant model, and were -∞, -0.812, -∞, -∞, and 0.087 respectively in autosomal recessive model. The LOD scores of D2S152 with ARVC in LW, WD, DS, LC and TY pedigrees were -, -0.539, -, and 0.602 respectively in autosomal dominant model and were -, -∞, -∞, -∞, and -∞ respectively in autosomal recessive model. Conclusions The LOD score for D2S152 in the LW pedigree was 2.174, indicating that the chance of linkage is about 150∶ 1. This suggests that there is a possible ARVC-related gene near this marker. There were no clear linkage relationships between ARVC and D10S1664 and D14S252 in this family, and no linkages between ARVC and any of the three genetic markers in the other four families. These results also suggest that there is genetic heterogeneity in LW and in the other pedigrees.

  16. Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.

    Wei, Ying-Jie; Huang, Yin-Xia; Shen, Ya; Cui, Chuan-Jue; Zhang, Xiao-Ling; Zhang, Hao; Hu, Sheng-Shou


    As proteins are the ultimate biological determinants of phenotype of disease, we screened altered proteins associated with heart failure due to arrhythmogenic right ventricular cardiomyopathy (ARVC) to identify biomarkers potential for rapid diagnosis of heart failure. By 2-dimensional gel electrophoresis and mass spectrometry, we identified five commonly altered proteins with more than 1.5 fold changes in eight ARVC failing hearts using eight non-failing hearts as reference. Noticeably, one of the altered proteins, heat shock protein 70 (HSP70), was increased by 1.64 fold in ARVC failing hearts compared with non-failing hearts. The increase of cardiac HSP70 was further validated by Western blot, immunochemistry, and enzyme-linked immunosorbent assay (ELISA) in failing hearts due to not only ARVC, but also dilated (DCM, n = 18) and ischemic cardiomyopathy (ICM, n = 8). Serum HSP70 was also observed to be significantly increased in heart failure patients derived from the three forms of cardiomyopathies. In addition, we observed hypoxia/serum depletion stimulation induced significantly elevation of intracellular and extracellular HSP70 in cultured neonatal rat cardiomyocytes. For the first time to our knowledge, we revealed and clearly demonstrated significant up-regulation of cardiac and serum HSP70 in ARVC heart failure patients. Our results indicate that elevated HSP70 is the common feature of heart failure due to ARVC, DCM, and ICM, which suggests that HSP70 may be used as a biomarker for the presence of heart failure due to cardiomyopathies of different etiologies and may hold diagnostic/prognostic potential in clinical practice.

  17. Development of an semi-automatic and sensitive photochemically induced fluorescence sensor for the determination of thiamethoxam in vegetables.

    Jiménez-López, J; Ortega-Barrales, P; Ruiz-Medina, A


    The determination of thiamethoxam (TMX), a widely known neonicotinoid pesticide, by a multicommutated optosensing device implemented with photochemically induced fluorescence (PIF) has been developed. The combination of both methodologies allows, on one hand a quick on-line photodegradation of TMX and, on the other hand, the preconcentration, quantification and desorption of the fluorescent photoproduct generated once retained on C18 silica gel filling the flow-cell which was monitored at 353 and 407nm for excitation and emission wavelengths, respectively. The proposed analytical method presents a detection limit of 3.6ngmL(-1) by using Multicommutated Flow Injection Analysis (MCFIA) as flow methodology. Recovery experiments have been carried out in different kinds of vegetables at levels same or below the legislated maximum residue limit, demonstrating that this method combines advantages such as simplicity, high sensibility and high selectivity, in addition to fulfill the requirements for its applications in quality control. The obtained results in the analysis of real samples were in good agreement with those provided by a reference liquid chromatography (HPLC) method.

  18. "Awakening to" a new meaning of being at-risk for arrhythmogenic right ventricular cardiomyopathy: a grounded theory study.

    Manuel, April; Brunger, Fern


    Efforts of social scientists to understand how individuals living in a family at risk for a genetically linked condition make health care decisions, having brought to the forefront the contextual nature of risk perception. Using a grounded theory approach, this study examines the experiences of 29 individuals living in families at risk for arrhythmogenic right ventricular cardiomyopathy (ARVC). Attention is paid to how individuals (re)construct the meaning of being at risk in relation to the developing science of gene discovery. Findings highlight that individuals living in a family at risk for ARVC juxtapose existing scientific knowledge against experiential knowledge as they "awaken to" the fact that they or a family member are at risk. This process is pragmatic and fluid and contingent upon whether and how symptoms are aligned with the constructed image of the at-risk relative.

  19. Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members

    Saberniak, Jørg; Hasselberg, Nina E; Borgquist, Rasmus;


    patients and 45 mutation-positive family members. Athletes were defined as subjects with ≥4 h vigorous exercise/week [≥1440 metabolic equivalents (METs × minutes/week)] during a minimum of 6 years. Athlete definition was fulfilled in 37/110 (34%) subjects. We assessed right ventricular (RV) and left......AIMS: Exercise increases risk of ventricular arrhythmia in subjects with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the impact of exercise on myocardial function in ARVC subjects. METHODS AND RESULTS: We included 110 subjects (age 42 ± 17 years), 65 ARVC...... family members (47 ± 3% vs. 52 ± 6%, P 

  20. Evaluation and automatic correction of metal-implant-induced artifacts in MR-based attenuation correction in whole-body PET/MR imaging.

    Schramm, G; Maus, J; Hofheinz, F; Petr, J; Lougovski, A; Beuthien-Baumann, B; Platzek, I; van den Hoff, J


    The aim of this paper is to describe a new automatic method for compensation of metal-implant-induced segmentation errors in MR-based attenuation maps (MRMaps) and to evaluate the quantitative influence of those artifacts on the reconstructed PET activity concentration. The developed method uses a PET-based delineation of the patient contour to compensate metal-implant-caused signal voids in the MR scan that is segmented for PET attenuation correction. PET emission data of 13 patients with metal implants examined in a Philips Ingenuity PET/MR were reconstructed with the vendor-provided method for attenuation correction (MRMap(orig), PET(orig)) and additionally with a method for attenuation correction (MRMap(cor), PET(cor)) developed by our group. MRMaps produced by both methods were visually inspected for segmentation errors. The segmentation errors in MRMap(orig) were classified into four classes (L1 and L2 artifacts inside the lung and B1 and B2 artifacts inside the remaining body depending on the assigned attenuation coefficients). The average relative SUV differences (ε(rel)(av)) between PET(orig) and PET(cor) of all regions showing wrong attenuation coefficients in MRMap(orig) were calculated. Additionally, relative SUV(mean) differences (ε(rel)) of tracer accumulations in hot focal structures inside or in the vicinity of these regions were evaluated. MRMap(orig) showed erroneous attenuation coefficients inside the regions affected by metal artifacts and inside the patients' lung in all 13 cases. In MRMap(cor), all regions with metal artifacts, except for the sternum, were filled with the soft-tissue attenuation coefficient and the lung was correctly segmented in all patients. MRMap(cor) only showed small residual segmentation errors in eight patients. ε(rel)(av) (mean ± standard deviation) were: (-56 ± 3)% for B1, (-43 ± 4)% for B2, (21 ± 18)% for L1, (120 ± 47)% for L2 regions. ε(rel) (mean ± standard deviation) of hot focal structures were: (-52

  1. The ‘Continuing Misfortune’ of Automatism in Early Surrealism

    Tessel M. Bauduin


    Full Text Available In the 1924 Manifesto of Surrealism surrealist leader André Breton (1896-1966 defined Surrealism as ‘psychic automatism in its pure state,’ positioning ‘psychic automatism’ as both a concept and a technique. This definition followed upon an intense period of experimentation with various forms of automatism among the proto-surrealist group; predominantly automatic writing, but also induced dream states. This article explores how surrealist ‘psychic automatism’ functioned as a mechanism for communication, or the expression of thought as directly as possible through the unconscious, in the first two decades of Surrealism. It touches upon automatic writing, hysteria as an automatic bodily performance of the unconscious, dreaming and the experimentation with induced dream states, and automatic drawing and other visual arts-techniques that could be executed more or less automatically as well. For all that the surrealists reinvented automatism for their own poetic, artistic and revolutionary aims, the automatic techniques were primarily drawn from contemporary Spiritualism, psychical research and experimentation with mediums, and the article teases out the connections to mediumistic automatism. It is demonstrated how the surrealists effectively and successfully divested automatism of all things spiritual. It furthermore becomes clear that despite various mishaps, automatism in many forms was a very successful creative technique within Surrealism.

  2. Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells

    Smit, Nicoline W.; ten Sande, Judith N.; Parvizi, Mojtaba; van Amersfoorth, Shirley C. M.; Plantinga, Josee A.; van Spreuwel-Goossens, Carolien A. F. M.; van Dongen, Elisabeth M. W. M.; van Dessel, Pascal F. H. M.; Kluijtmans, Sebastianus G. J. M.; Meijborg, Veronique M. F.; de Bakker, Jacques M. T.; Harmsen, Martin C.; Coronel, Ruben


    Background Stem cell therapy to improve cardiac function after myocardial infarction is hampered by poor cell retention, while it may also increase the risk of arrhythmias by providing an arrhythmogenic substrate. We previously showed that porcine adipose tissue-derived-stromal cells (pASC) induce

  3. Automatic Fiscal Stabilizers

    Narcis Eduard Mitu


    Full Text Available Policies or institutions (built into an economic system that automatically tend to dampen economic cycle fluctuations in income, employment, etc., without direct government intervention. For example, in boom times, progressive income tax automatically reduces money supply as incomes and spendings rise. Similarly, in recessionary times, payment of unemployment benefits injects more money in the system and stimulates demand. Also called automatic stabilizers or built-in stabilizers.

  4. Automatic differentiation bibliography

    Corliss, G.F. (comp.)


    This is a bibliography of work related to automatic differentiation. Automatic differentiation is a technique for the fast, accurate propagation of derivative values using the chain rule. It is neither symbolic nor numeric. Automatic differentiation is a fundamental tool for scientific computation, with applications in optimization, nonlinear equations, nonlinear least squares approximation, stiff ordinary differential equation, partial differential equations, continuation methods, and sensitivity analysis. This report is an updated version of the bibliography which originally appeared in Automatic Differentiation of Algorithms: Theory, Implementation, and Application.

  5. Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.

    Fish, Maryam; Shaboodien, Gasnat; Kraus, Sarah; Sliwa, Karen; Seidman, Christine E; Burke, Michael A; Crotti, Lia; Schwartz, Peter J; Mayosi, Bongani M


    Cardiomyopathy is an important cause of heart failure in Sub-Saharan Africa, accounting for up to 30% of adult heart failure hospitalisations. This high prevalence poses a challenge in societies without access to resources and interventions essential for disease management. Over 80 genes have been implicated as a cause of cardiomyopathy. Mutations in the phospholamban (PLN) gene are associated with dilated cardiomyopathy (DCM) and severe heart failure. In Africa, the prevalence of PLN mutations in cardiomyopathy patients is unknown. Our aim was to screen 315 patients with arrhythmogenic right ventricular cardiomyopathy (n = 111), DCM (n = 95), hypertrophic cardiomyopathy (n = 40) and peripartum cardiomyopathy (n = 69) for disease-causing PLN mutations by high resolution melt analysis and DNA sequencing. We detected the previously reported PLN c.25C > T (p.R9C) mutation in a South African family with severe autosomal dominant DCM. Haplotype analysis revealed that this mutation occurred against a different haplotype background to that of the original North American family and was therefore unlikely to have been inherited from a common ancestor. No other mutations in PLN were detected (mutation prevalence = 0.2%). We conclude that PLN is a rare cause of cardiomyopathy in African patients. The PLN p.R9C mutation is not well-tolerated, emphasising the importance of this gene in cardiac function.

  6. Stop-gain mutations in PKP2 are associated with a later age of onset of arrhythmogenic right ventricular cardiomyopathy.

    Mireia Alcalde

    Full Text Available BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC is a cardiac disease characterized by the presence of fibrofatty replacement of the right ventricular myocardium, which may cause ventricular arrhythmias and sudden cardiac death. Pathogenic mutations in several genes encoding mainly desmosomal proteins have been reported. Our aim is to perform genotype-phenotype correlations to establish the diagnostic value of genetics and to assess the role of mutation type in age-related penetrance in ARVC. METHODS AND RESULTS: Thirty unrelated Spanish patients underwent a complete clinical evaluation. They all were screened for PKP2, DSG2, DSC2, DSP, JUP and TMEM43 genes. A total of 70 relatives of four families were also studied. The 30 patients fulfilled definite disease diagnostic criteria. Genetic analysis revealed a pathogenic mutation in 19 patients (13 in PKP2, 3 in DSG2, 2 in DSP, and 1 in DSC2. Nine of these mutations created a truncated protein due to the generation of a stop codon. Familial assessment revealed 28 genetic carriers among family members. Stop-gain mutations were associated to a later age of onset of ARVC, without differences in the severity of the pathology. CONCLUSIONS: Familial genetic analysis helps to identify the cause responsible for the pathology. In discrepancy with previous studies, the presence of a truncating protein does not confer a worse severity. This information could suggest that truncating proteins may be compensated by the normal allele and that missense mutations may act as poison peptides.

  7. Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy

    Rajkumar Revathi


    Full Text Available Abstract Background The Ser358Leu mutation in TMEM43, encoding an inner nuclear membrane protein, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC. The pathogenetic mechanisms of this mutation are poorly understood. Methods To determine the frequency of TMEM43 mutations as a cause of ARVC, we screened 11 ARVC families for mutations in TMEM43 and five desmosomal genes previously implicated in the disease. Functional studies were performed in COS-7 cells transfected with wildtype, mutant, and 1:2 wildtype:mutant TMEM43 to determine the effect of the Ser358Leu mutation on the stability and cellular localization of TMEM43 and other nuclear envelope and desmosomal proteins, assessed by solubility assays and immunofluorescence imaging. mRNA expression was assessed of genes potentially affected by dysfunction of the nuclear lamina. Results Three novel mutations in previously documented desmosomal genes, but no mutations in TMEM43, were identified. COS-7 cells transfected with mutant TMEM43 exhibited no change in desmosomal stability. Stability and nuclear membrane localization of mutant TMEM43 and of lamin B and emerin were normal. Mutant TMEM43 did not alter the expression of genes located on chromosome 13, previously implicated in nuclear envelope protein mutations leading to skeletal muscular dystrophies. Conclusions Mutant TMEM43 exhibits normal cellular localization and does not disrupt integrity and localization of other nuclear envelope and desmosomal proteins. The pathogenetic role of TMEM43 mutations in ARVC remains uncertain.

  8. Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in a young female athlete at 36 weeks gestation: a case report.

    Choung, Hae Yoon Grace; Vyas, Monika; Jacoby, Daniel; West, Brian


    A 26year old east African professional athlete presented to the obstetric clinic for a routine visit at 36 weeks gestation. She had a history of Right Ventricular Outflow Tract - Ventricular Tachycardia (RVOT-VT) with an episode of cardiac arrest in the past, and had been treated with ablation 4 years earlier. Her current visit was uneventful, her pregnancy progressing normally. Following the visit she went to a local restaurant where she suffered a cardiac arrest that was unresponsive to therapy. Chest compressions were continued from the time of her collapse until an emergency caesarian section was performed, delivering a healthy female infant. At autopsy a focal area of subtle pallor and myocardial thinning was present at the apex of the right ventricle. Histology showed myocyte degeneration and loss with focal full thickness replacement of myocardium by adipose tissue, consistent with the fatty form of arrhythmogenic right ventricular cardiomyopathy (ARVC). Molecular studies revealed a variant of unknown significance in the MYBPC3 gene, but no variant known to be associated with ARVC. In view of the subtlety of the lesion on gross examination this diagnosis could have been easily missed, emphasizing the importance of performing histologic examination of subtle gross cardiac lesions. Copyright © 2017 Elsevier GmbH. All rights reserved.

  9. A mutation in the Z-line Cypher/ZASP protein is associated with arrhythmogenic right ventricular cardiomyopathy.

    Lopez-Ayala, J M; Ortiz-Genga, M; Gomez-Milanes, I; Lopez-Cuenca, D; Ruiz-Espejo, F; Sanchez-Munoz, J J; Oliva-Sandoval, M J; Monserrat, L; Gimeno, J R


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of malignant arrhythmia and sudden death particularly in young people. Although it is considered a desmosomal disease, mutations in non-desmosomal genes have also been identified. We report on a family where a mutation in LDB3 is associated with this condition. The index case and first and second degree relatives underwent a complete clinical evaluation: physical examination, electrocardiography (ECG), signal-averaged ECG, 2D echocardiogram, cardiac magnetic resonance and 24-h monitoring. After ruling out mutations in the five desmosomal genes, genetic testing by means of Next Generation Sequencing was carried out on the proband. A heterozygous missense mutation in LDB3 c.1051A>G was identified. This result was confirmed by subsequent Sanger DNA sequencing. Another six carriers were identified amongst her relatives. Three subjects fulfilled the criteria for a definitive diagnosis of ARVC and one reached a borderline diagnosis. In conclusion, this is the first family with ARVC where a mutation in LDB3 is associated with ARVC. Next generation sequencing arises as a particular useful tool to point to new causative genes in ARVC.

  10. Mediation and Automatization.

    Hutchins, Edwin

    This paper discusses the relationship between the mediation of task performance by some structure that is not inherent in the task domain itself and the phenomenon of automatization, in which skilled performance becomes effortless or phenomenologically "automatic" after extensive practice. The use of a common simple explicit mediating…

  11. Automatic Differentiation Package


    Sacado is an automatic differentiation package for C++ codes using operator overloading and C++ templating. Sacado provide forward, reverse, and Taylor polynomial automatic differentiation classes and utilities for incorporating these classes into C++ codes. Users can compute derivatives of computations arising in engineering and scientific applications, including nonlinear equation solving, time integration, sensitivity analysis, stability analysis, optimization and uncertainity quantification.

  12. Digital automatic gain control

    Uzdy, Z.


    Performance analysis, used to evaluated fitness of several circuits to digital automatic gain control (AGC), indicates that digital integrator employing coherent amplitude detector (CAD) is best device suited for application. Circuit reduces gain error to half that of conventional analog AGC while making it possible to automatically modify response of receiver to match incoming signal conditions.

  13. Focusing Automatic Code Inspections

    Boogerd, C.J.


    Automatic Code Inspection tools help developers in early detection of defects in software. A well-known drawback of many automatic inspection approaches is that they yield too many warnings and require a clearer focus. In this thesis, we provide such focus by proposing two methods to prioritize

  14. Chamber-specific effects of hypokalaemia on ventricular arrhythmogenicity in isolated, perfused guinea-pig heart

    Osadchii, Oleg E; Bentzen, Bo Hjorth; Olesen, Søren-Peter


    Diuretic-induced hypokalaemia has been shown to promote cardiac arrhythmias in hypertensive patients. The present study was designed to determine whether hypokalaemia increases arrhythmic susceptibility of the left ventricle (LV) or the right ventricle (RV), or both. Proarrhythmic effects of hypo...




    In a woman with an old infarction and sustained ventricular tachycardia, tachycardias were only inducible after short-long RR sequences. After isoprenaline, tachycardias became incessant and all were preceded by short-long RR sequences. This strongly suggests that triggered activity plays a role in

  16. Arrhythmogenic effects of hypoglycemia in children and adolescents with type 1 diabetes mellitus

    Dmitriy Nikitich Laptev


    Full Text Available Aim. To determine the effects of hypoglycemia on the duration of QT interval, heart rate variability (HRV and frequency of arrhythmic events, as well as to closer investigate the factors associated with the development of various heart rhythm disorders in children and adolescents with type 1 diabetes mellitus (T1DM.Materials and methods. The study included 150 children and adolescents with T1DM at the age of 6–18 years. All participants underwent Holter monitoring and continuous glucose monitoring (CGM for 24 hours. QTc and HRV parameters (SDNN, RMSSD, SVVR were calculated automatically. Data was averaged for 5’-interval and juxtaposed with CGM. Patients identified with hypoglycemic events (blood glucose <3.5 mmol/L during the day (7:00–23:00 and nighttime (23:00–7:00 were selected for further study. In these patients length of QTc and RR intervals, HRV parameters and arrhythmic events were analyzed and collated with CGM data.Results. We observed 39 episodes of nocturnal hypoglycaemia in 32 patients (21.3% and 89 episodes of daytime hypoglycaemia in 46 patients (30.7%. Marked prolongation of QTc (hypo- vs. normoglycemia, respectively: 431 vs. 420 ms; p<0.05 and reduced HRV (hypo- vs. normoglycemia, respectively: SDNN 68 and 90 ms; RMSSD 56 and 61 ms; p <0.05 occurred during episodes of nocturnal hypoglycemia. The same pattern was observed during the day (hypo- vs. normoglycemia, respectively: SDNN 58 and 63 ms; RMSSD 32 and 36 ms; p<0.05. Eleven subjects with nocturnal hypoglycemia demonstrated either ventricular or supraventricular premature complexes. Thirty of subjects with diurnal hypoglycemia also had either ventricular or supraventricular premature complexes. Hypoglycemic episodes vs. normoglycemia were characterized by an increase in ventricular and supraventricular ectopic beats, ST segment and T-wave amplitude depression. Various rhythm abnormalities were associated with cardiovascular autonomic and peripheral neuropathy

  17. Arrhythmogenic Right Ventricular Cardiomyopathy - 4 Swedish families with an associated PKP2 c.2146-1G>C variant

    Svensson, Anneli; Åström-Aneq, Meriam; Widlund, Kjerstin Ferm; Fluur, Christina; Green, Anna; Rehnberg, Malin; Gunnarsson, Cecilia


    In this study, the genotype-phenotype correlations in four unrelated families with a PKP2 c.2146-1G>C gene variant were studied. Our primary aim was to determine the carriers that fulfilled the arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnostic criteria of 2010. Our secondary aim was to investigate whether any specific clinical characteristics can be attributed to this particular gene variant. Index patients were assessed using next generation ARVC panel sequencing technique and their family members were assessed by Sanger sequencing targeted at the PKP2 c.2146-1G>C variant. The gene variant carriers were offered a clinical follow-up, with evaluation based on the patient’s history and a standard set of non-invasive testing. The PKP2 c.2146-1G>C gene variant was found in 23 of 41 patients who underwent the examination. Twelve of the 19 family members showed “possible ARVC”. One with “borderline ARVC” and the rest with “definite ARVC” demonstrated re-polarization disturbances, but arrhythmia was uncommon. A lethal event occurred in a 14-year-old boy. In the present study, no definitive genotype-phenotype correlations were found, where the majority of the family members carrying the PKP2 c.2146-1G>C gene variant were diagnosed with “possible ARVC”. These individuals should be offered a long-term follow-up since they are frequently symptomless but still at risk for insidious sudden cardiac death due to ventricular arrhythmia. PMID:27335691

  18. Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model.

    Chang, Po-Cheng; Wo, Hung-Ta; Lee, Hui-Ling; Wen, Ming-Shien; Chou, Chung-Chuan


    Na(+)/Ca(2+) exchanger blockade has been reported to be anti-arrhythmic in different models. The effects of KB-R7943, a Na(+)/Ca(2+) exchanger blocker, on arrhythmogenesis in hearts with chronic myocardial infarction (MI) remain unclear. Dual voltage and intracellular Ca(2+) (Cai) optical mapping was performed in nine rabbit hearts with chronic MI and four control hearts. Electrophysiology studies including inducibility of ventricular tachyarrhythmias, ventricular fibrillation dominant frequency, action potential, Cai alternans, Cai decay, and conduction velocity were performed. The same protocol was repeated in the presence of KB-R7943 (0.5, 1, and 5μM) after the baseline studies. KB-R7943 was effective in suppressing afterdepolarizations and spontaneous ventricular tachyarrhythmias in hearts with chronic MI. Surprisingly, KB-R7943 increased the inducibility of ventricular tachyarrhythmias in a dose-dependent manner (11%, 11%, 22%, and 56% at baseline and with 0.5, 1, and 5μM KB-R7943, respectively, p=0.02). Optical mapping analysis revealed that the underlying mechanisms of the induced ventricular tachyarrhythmias were probably spatially discordant alternans with wave breaks and rotors. Further analysis showed that KB-R7943 significantly enhanced both action potential (p=0.033) and Cai (p=0.001) alternans, prolonged Cai decay (tau value) in a dose-dependent manner (p=0.004), and caused heterogeneous conduction delay especially at peri-infarct zones during rapid burst pacing. In contrast, KB-R7943 had insignificant effects in control hearts. In this chronic MI rabbit model, KB-R7943 has contrasting effects on arrhythmogenesis, suppressing afterdepolarizations and spontaneous ventricular tachyarrhythmias, but enhancing the inducibility of tachyarrhythmias. The mechanism is probably the enhanced spatially discordant alternans because of prolonged Cai decay and heterogeneous conduction delay. Copyright © 2014 Japanese College of Cardiology. Published by Elsevier

  19. Word Automaticity of Tree Automatic Scattered Linear Orderings Is Decidable

    Huschenbett, Martin


    A tree automatic structure is a structure whose domain can be encoded by a regular tree language such that each relation is recognisable by a finite automaton processing tuples of trees synchronously. Words can be regarded as specific simple trees and a structure is word automatic if it is encodable using only these trees. The question naturally arises whether a given tree automatic structure is already word automatic. We prove that this problem is decidable for tree automatic scattered linear orderings. Moreover, we show that in case of a positive answer a word automatic presentation is computable from the tree automatic presentation.

  20. Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy.

    Ruwald, Anne-Christine; Marcus, Frank; Estes, N A Mark; Link, Mark; McNitt, Scott; Polonsky, Bronislava; Calkins, Hugh; Towbin, Jeffrey A; Moss, Arthur J; Zareba, Wojciech


    It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death. Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651). Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death. Identifier: NCT00024505. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email:

  1. The natural history of a genetic subtype of arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in TMEM43.

    Hodgkinson, K A; Connors, S P; Merner, N; Haywood, A; Young, T-L; McKenna, W J; Gallagher, B; Curtis, F; Bassett, A S; Parfrey, P S


    To determine the phenotype and natural history of a founder genetic subtype of autosomal dominant arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by a p.S358L mutation in TMEM43. The age of onset of cardiac symptoms, clinical events and test abnormalities were studied in 412 subjects (258 affected and 154 unaffected), all of which occurred in affected males significantly earlier and more often than unaffected males. Affected males were hospitalized four times more often than affected females (p ≤ 0.0001) and died younger (p ≤ 0.001). The temporal sequence from symptoms onset to death was prolonged in affected females by 1-2 decades. The most prevalent electrocardiogram (ECG) manifestation was poor R wave progression (PRWP), with affected males twice as likely to develop PRWP as affected females (p ≤ 0.05). Left ventricular enlargement (LVE) occurred in 43% of affected subjects, with 11% fulfilling criteria for dilated cardiomyopathy. Ventricular ectopy on Holter monitor was common and occurred early: the most diagnostically useful clinical test. No symptom or test could rule out diagnosis. This ARVC subtype is a sex-influenced lethal arrhythmogenic cardiomyopathy, with a unique ECG finding, LV dilatation, heart failure and early death, where molecular pre-symptomatic diagnosis has the greatest clinical utility. © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  2. New Features of Electrocardiogram in a Case Report of Arrhythmogenic Right Ventricular Cardiomyopathy: A Care-Compliant Article.

    Pei, Haifeng; Yu, Qiujun; Su, Xiaohua; Wang, Zhen; Zhao, Heng; Yang, Dachun; Yang, Yongjian; Li, De


    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a crucial health problem. With sudden death often being the first presentation, early diagnosis for ARVC is essential. Up to date, electrocardiogram (ECG) is a widely used diagnostic method without invasive harms. To diagnose and treat ARVC as well as possible, we should clearly elucidate its pathophysiological alterations. A 66-year-old farmer presented to the Emergency Department with continuous palpitation, chest tightness, profuse sweating, and nausea with no obvious predisposing causes. An ECG indicated ventricular tachycardia (VT). The patient experienced a sudden drop in blood pressure and acute confusion. After an immediate electrical conversion, his consciousness was gradually restored, and symptoms relieved. The patient was then transferred to the Department of Cardiology to receive ECG, echocardiography, coronary angiogram, biochemical assays, endocardiac tracing, and radiofrequency ablation. In the end, he was diagnosed with ARVC, evidenced by bilateral ventricle dilation and epsilon waves in leads V1-V3. Appropriate therapies were provided for this patient including pharmacological intervention and radiofrequency ablation. Although the diagnosis of ARVC is not difficult, this patient's ECG manifested several interesting features and should be further investigated: T wave inversions were found extensively in the anterior and inferior leads, revealing the involvement of bilateral ventricles; VTs with different morphologies and cycle lengths were found, and some VTs manifested the feature of irregularly irregular rhythm, reminding us to carefully differentiate some special VTs from atrial fibrillation (AF); and epsilon waves gradually appeared in leads V1-V3 and avR since the onset of ARVC. Most importantly, the epsilon waves behind QRS complex appeared in both sinus rhythm and ventricular premature beats/VT originating from cardiac apex, whereas the epsilon waves prior to QRS complex occurred in

  3. Reader- and instrument-dependent variability in the electrocardiographic assessment of arrhythmogenic right ventricular dysplasia/cardiomyopathy.

    Jain, Rahul; Tandri, Harikrishna; Daly, Amy; Tichnell, Crystal; James, Cynthia; Abraham, Theodore; Judge, Daniel P; Calkins, Hugh; Dalal, Darshan


    Despite the use of standardized definitions, widely varying prevalence estimates of electrocardiographic (ECG) features related to arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) have been reported in different cohorts. This study was aimed at examining the variability in the ECG interpretation resulting from the same reader, different readers, and using different ECG-resolutions. Blinded to other clinical data, 2 readers examined quantitative and qualitative ECG features of 20 (10 ARVD/C) randomly selected individuals. ECGs were recorded at standard-speed (SS) and double-speed-double-amplitude (DS) settings. The SS ECGs were scanned, magnified 4×, and evaluated using electronic calipers (EL). One reader repeated all measurements. For both readers, the intraclass correlation coefficient (ICC) for the measurement of QRS duration was good between conventional and electronic evaluation [DS vs EL: Reader 1--0.64 (0.52-0.73); Reader 2--0.67 (0.55-0.76)][SS vs EL: Reader 1--0.60 (0.47-0.70); Reader 2--0.60 (0.47-0.70)]. Using the same resolution, the intrareader ICC was good for SS [0.70 (0.59-0.78)], DS [0.85 (0.80-0.90)], and EL [0.70 (0.69-0.83)] resolutions, but deteriorated for interreader comparisons [0.50 (0.36-0.62), 0.75 (0.66-0.82), and 0.75 (0.66-0.82), respectively]. For qualitative parameters, the intra- and interreader agreement was inconsistent for all but 2 parameters. Both readers were in perfect agreement while interpreting right precordial T-wave inversion [κ= 1] and right bundle branch block morphology (RBBB) [κ= 0.83 (0.5-1.0)] even when using SS resolution. Right precordial t-wave inversion and RBBB are the only ECG parameters that can be detected consistently even using the conventionally used ECG-resolution. The substantial variability in evaluation of other parameters is not improved even with the use of higher resolutions. © 2010 Wiley Periodicals, Inc.

  4. Automatic Program Development

    by members of the IFIP Working Group 2.1 of which Bob was an active member. All papers are related to some of the research interests of Bob and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications. Automatic Program Development offers......Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his...... honor in the Higher-Order and Symbolic Computation Journal in the years 2003 and 2005. Among them there are two papers by Bob: (i) a retrospective view of his research lines, and (ii) a proposal for future studies in the area of the automatic program derivation. The book also includes some papers...

  5. Automatic text summarization

    Torres Moreno, Juan Manuel


    This new textbook examines the motivations and the different algorithms for automatic document summarization (ADS). We performed a recent state of the art. The book shows the main problems of ADS, difficulties and the solutions provided by the community. It presents recent advances in ADS, as well as current applications and trends. The approaches are statistical, linguistic and symbolic. Several exemples are included in order to clarify the theoretical concepts.  The books currently available in the area of Automatic Document Summarization are not recent. Powerful algorithms have been develop

  6. Automatic Camera Control

    Burelli, Paolo; Preuss, Mike


    Automatically generating computer animations is a challenging and complex problem with applications in games and film production. In this paper, we investigate howto translate a shot list for a virtual scene into a series of virtual camera configurations — i.e automatically controlling the virtual...... camera. We approach this problem by modelling it as a dynamic multi-objective optimisation problem and show how this metaphor allows a much richer expressiveness than a classical single objective approach. Finally, we showcase the application of a multi-objective evolutionary algorithm to generate a shot...

  7. Exploring Automatization Processes.

    DeKeyser, Robert M.


    Presents the rationale for and the results of a pilot study attempting to document in detail how automatization takes place as the result of different kinds of intensive practice. Results show that reaction times and error rates gradually decline with practice, and the practice effect is skill-specific. (36 references) (CK)

  8. Automatic Complexity Analysis

    Rosendahl, Mads


    One way to analyse programs is to to derive expressions for their computational behaviour. A time bound function (or worst-case complexity) gives an upper bound for the computation time as a function of the size of input. We describe a system to derive such time bounds automatically using abstrac...

  9. Brut: Automatic bubble classifier

    Beaumont, Christopher; Goodman, Alyssa; Williams, Jonathan; Kendrew, Sarah; Simpson, Robert


    Brut, written in Python, identifies bubbles in infrared images of the Galactic midplane; it uses a database of known bubbles from the Milky Way Project and Spitzer images to build an automatic bubble classifier. The classifier is based on the Random Forest algorithm, and uses the WiseRF implementation of this algorithm.

  10. Automatic Dance Lesson Generation

    Yang, Yang; Leung, H.; Yue, Lihua; Deng, LiQun


    In this paper, an automatic lesson generation system is presented which is suitable in a learning-by-mimicking scenario where the learning objects can be represented as multiattribute time series data. The dance is used as an example in this paper to illustrate the idea. Given a dance motion sequence as the input, the proposed lesson generation…

  11. Automaticity and Reading: Perspectives from the Instance Theory of Automatization.

    Logan, Gordon D.


    Reviews recent literature on automaticity, defining the criteria that distinguish automatic processing from non-automatic processing, and describing modern theories of the underlying mechanisms. Focuses on evidence from studies of reading and draws implications from theory and data for practical issues in teaching reading. Suggests that…

  12. The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

    Søndergaard, Mads Toft; Liu, Yingjie; Larsen, Kamilla Taunsig


    (ryanodine receptor, RyR2), and it appears that attenuated CaM Ca2+-binding correlates with impaired CaM-dependent RyR2 inhibition. Here, we investigated the RyR2 inhibitory action of the CaM p.Phe142Leu mutation (F142L; numbered including the start methionine), which markedly reduces CaM Ca2+-binding...... to our understanding of CaM-dependent regulation of RyR2 as well as the mechanistic effects of arrhythmogenic CaM mutations. The unique properties of the CaM-F142L mutation may provide novel clues on how to suppress excessive RyR2 Ca2+-release by manipulating the CaM-RyR2 interaction....

  13. Arrhythmogenic Right Ventricular Dysplasia

    ... Health, Kids and Teens, Men, WomenTags: Arrhythmias, Cardiac stress test, cardiovascular, EKG, Holter monitoring Family Health, Kids and Teens, Men, Women April 2006 Copyright © American Academy of ...

  14. Seizures following hippocampal kindling induce QT interval prolongation and increased susceptibility to arrhythmias in rats.

    Bealer, Steven L; Little, Jason G


    The prolonged seizures of status epilepticus produce chronic arrhythmogenic changes in cardiac function. This study was designed to determine if repeated, self-limiting seizures administered to kindled rats induce similar cardiac dysfunction. Multiple seizures administered to rats following hippocampal kindling resulted in cardiac QT interval prolongation and increased susceptibility to experimental arrhythmias. These data suggest that multiple, self-limiting seizures of intractable epilepsy may have cardiac effects that can contribute to sudden unexpected death in epilepsy (SUDEP).

  15. Automatic Ultrasound Scanning

    Moshavegh, Ramin

    Medical ultrasound has been a widely used imaging modality in healthcare platforms for examination, diagnostic purposes, and for real-time guidance during surgery. However, despite the recent advances, medical ultrasound remains the most operator-dependent imaging modality, as it heavily relies...... on the user adjustments on the scanner interface to optimize the scan settings. This explains the huge interest in the subject of this PhD project entitled “AUTOMATIC ULTRASOUND SCANNING”. The key goals of the project have been to develop automated techniques to minimize the unnecessary settings...... on the scanners, and to improve the computer-aided diagnosis (CAD) in ultrasound by introducing new quantitative measures. Thus, four major issues concerning automation of the medical ultrasound are addressed in this PhD project. They touch upon gain adjustments in ultrasound, automatic synthetic aperture image...

  16. Automatic trend estimation

    Vamos¸, C˘alin


    Our book introduces a method to evaluate the accuracy of trend estimation algorithms under conditions similar to those encountered in real time series processing. This method is based on Monte Carlo experiments with artificial time series numerically generated by an original algorithm. The second part of the book contains several automatic algorithms for trend estimation and time series partitioning. The source codes of the computer programs implementing these original automatic algorithms are given in the appendix and will be freely available on the web. The book contains clear statement of the conditions and the approximations under which the algorithms work, as well as the proper interpretation of their results. We illustrate the functioning of the analyzed algorithms by processing time series from astrophysics, finance, biophysics, and paleoclimatology. The numerical experiment method extensively used in our book is already in common use in computational and statistical physics.

  17. Automatic food decisions

    Mueller Loose, Simone

    Consumers' food decisions are to a large extent shaped by automatic processes, which are either internally directed through learned habits and routines or externally influenced by context factors and visual information triggers. Innovative research methods such as eye tracking, choice experiments...... and food diaries allow us to better understand the impact of unconscious processes on consumers' food choices. Simone Mueller Loose will provide an overview of recent research insights into the effects of habit and context on consumers' food choices....

  18. Automatic food decisions

    Mueller Loose, Simone

    Consumers' food decisions are to a large extent shaped by automatic processes, which are either internally directed through learned habits and routines or externally influenced by context factors and visual information triggers. Innovative research methods such as eye tracking, choice experiments...... and food diaries allow us to better understand the impact of unconscious processes on consumers' food choices. Simone Mueller Loose will provide an overview of recent research insights into the effects of habit and context on consumers' food choices....

  19. Automatization of lexicographic work

    Iztok Kosem


    Full Text Available A new approach to lexicographic work, in which the lexicographer is seen more as a validator of the choices made by computer, was recently envisaged by Rundell and Kilgarriff (2011. In this paper, we describe an experiment using such an approach during the creation of Slovene Lexical Database (Gantar, Krek, 2011. The corpus data, i.e. grammatical relations, collocations, examples, and grammatical labels, were automatically extracted from 1,18-billion-word Gigafida corpus of Slovene. The evaluation of the extracted data consisted of making a comparison between the time spent writing a manual entry and a (semi-automatic entry, and identifying potential improvements in the extraction algorithm and in the presentation of data. An important finding was that the automatic approach was far more effective than the manual approach, without any significant loss of information. Based on our experience, we would propose a slightly revised version of the approach envisaged by Rundell and Kilgarriff in which the validation of data is left to lower-level linguists or crowd-sourcing, whereas high-level tasks such as meaning description remain the domain of lexicographers. Such an approach indeed reduces the scope of lexicographer’s work, however it also results in the ability of bringing the content to the users more quickly.

  20. Study on automatic assembly of CNPs based on light induced ACEO%基于光诱导电渗流的碳纳米颗粒自动化装配

    梁文峰; 曲艳丽; 董再励


    As a novel nano material with unique nanostructure and properties, carbon nano-particles (CNPs) show a great potential for biomedical and industry applications. However, how to automatically manipulate and assemble the CNPs is still very challenging. In this paper, a new method for automatic assembly of CNPs was proposed by utilizing light induced AC electro-osmotic (LI-ACEO). Based on the theoretical analysis of nano scale kinetics of CNPs in a non-uniform electrical field, the theoretical models of the slip velocity and the frequency range of the applied AC voltage were established and derived. Furthermore, the entire spatial distribution of the velocity caused by the LI-ACEO was simulated utilizing a commercial finite element simulation software Comsol Multiphysics. The optimal frequency of 1 kHz for the LI-ACEO manipulation was determined, and the mechanism of LI-ACEO was discussed in detail. The experimental results of 50nm CNPs proved that LI-ACEO is very effective for automatic manipulation and assembly of CNPs. The LI-ACEO also shows important potential for CNPs-based 3D nano structure and nano device building.%碳纳米颗粒作为一种新颖的纳米材料,在生物医学以及工业领域等具有重要应用价值.然而如何自动化的操控以及装配碳纳米颗粒仍然是难题.为此,文中提出了一种将光诱导交流电渗流应用于碳纳米颗粒的自动化装配的新方法.在分析了光诱导非均匀电场环境下碳纳米颗粒纳观尺度受力的基础上,率先建立了光诱导交流电渗流的滑移速度理论模型以及驱动交流电压频率模型,并利用有限元仿真软件Comsol Multiphysics仿真分析了光诱导交流电渗流的在整个空间的速度场分布,获得了光诱导交流电渗流起主导作用的有效频率范围,并得到其最优交流电压驱动频率为1 kHz,进而对操作机理进行了深入解释.50 nm碳颗粒的装配实验结果证明,光诱导交流电渗流方法可以成功

  1. Research on critical technology of the automatic assembly of CNPs utilizing the light induced AC electroosmotic%基于光诱导交流电渗流的碳纳米颗粒自动化装配技术

    梁文峰; 曲艳丽; 董再励


    As a novel nano material with unique nanostructure and properties, carbon nanoparticles (CNPs) show a great potential for bi-omedical material and energy applications. A new method of the automatic assembly of CNPs using light induced AC electroosmotic (LI-ACEO) was proposed. Based on the theoretical analysis of CNPs in condition with a non-uniform electrical field, the theoretical model of the slip velocity and the frequency range of the pull-in AC voltage was established and derived with the optimal frequency of 1 kHz. Furthermore, the entire spatial distribution of the velocity caused by the LI-ACEO was simulated utilizing commercial finite element simulation software Comsol Multiphysics. Combing the computer vision surveillance and the digital projection systems, the automatic assembly of CNPs system utilizing the LI-ACEO method was constructed. Our experimental results of 50 nm CNPs prove that LI-ACEO is very effective for automatic assembly and accumulation of CNPs with a amplitude of 3 V and a frequency of 1 kHz. In addition, the height of the assembly of CNPs structure is -1 μm. The technology based on the LI-ACEO also shows important applications for CNPs manipulation, assembly, 3D CNPs nano structure and nano sensor building.%碳纳米颗粒作为一种新颖的纳米材料,在生物医学、材料以及能源等领域都具有重要应用价值.提出一种基于光诱导交流电渗流的碳纳米颗粒自动化装配新方法.在分析了光诱导非均匀电场环境下碳纳米颗粒纳受力的基础上,建立了光诱导交流电渗流的滑移速度模型以及驱动交流电压频率模型,获得了其最优交流电压驱动频率为1 kHz,并利用有限元仿真软件Comsol Multiphysics仿真分析了光诱导交流电渗流在整个装配空间的速度场分布.结合计算机视觉监控和数字投影系统,构建了基于光诱导交流电渗流的碳纳米颗粒自动化装配实验系统,进行了50 nm碳颗粒的装配实验.实验结

  2. Automaticity or active control

    Tudoran, Ana Alina; Olsen, Svein Ottar

    This study addresses the quasi-moderating role of habit strength in explaining action loyalty. A model of loyalty behaviour is proposed that extends the traditional satisfaction–intention–action loyalty network. Habit strength is conceptualised as a cognitive construct to refer to the psychological...... aspects of the construct, such as routine, inertia, automaticity, or very little conscious deliberation. The data consist of 2962 consumers participating in a large European survey. The results show that habit strength significantly moderates the association between satisfaction and action loyalty, and...

  3. Automatic Configuration in NTP

    Jiang Zongli(蒋宗礼); Xu Binbin


    NTP is nowadays the most widely used distributed network time protocol, which aims at synchronizing the clocks of computers in a network and keeping the accuracy and validation of the time information which is transmitted in the network. Without automatic configuration mechanism, the stability and flexibility of the synchronization network built upon NTP protocol are not satisfying. P2P's resource discovery mechanism is used to look for time sources in a synchronization network, and according to the network environment and node's quality, the synchronization network is constructed dynamically.

  4. Automatic Complexity Analysis

    Rosendahl, Mads


    One way to analyse programs is to to derive expressions for their computational behaviour. A time bound function (or worst-case complexity) gives an upper bound for the computation time as a function of the size of input. We describe a system to derive such time bounds automatically using abstrac...... interpretation. The semantics-based setting makes it possible to prove the correctness of the time bound function. The system can analyse programs in a first-order subset of Lisp and we show how the system also can be used to analyse programs in other languages....

  5. Automaticity or active control

    Tudoran, Ana Alina; Olsen, Svein Ottar

    This study addresses the quasi-moderating role of habit strength in explaining action loyalty. A model of loyalty behaviour is proposed that extends the traditional satisfaction–intention–action loyalty network. Habit strength is conceptualised as a cognitive construct to refer to the psychologic......, respectively, between intended loyalty and action loyalty. At high levels of habit strength, consumers are more likely to free up cognitive resources and incline the balance from controlled to routine and automatic-like responses.......This study addresses the quasi-moderating role of habit strength in explaining action loyalty. A model of loyalty behaviour is proposed that extends the traditional satisfaction–intention–action loyalty network. Habit strength is conceptualised as a cognitive construct to refer to the psychological...... aspects of the construct, such as routine, inertia, automaticity, or very little conscious deliberation. The data consist of 2962 consumers participating in a large European survey. The results show that habit strength significantly moderates the association between satisfaction and action loyalty, and...

  6. Comparison of automatic control systems

    Oppelt, W


    This report deals with a reciprocal comparison of an automatic pressure control, an automatic rpm control, an automatic temperature control, and an automatic directional control. It shows the difference between the "faultproof" regulator and the actual regulator which is subject to faults, and develops this difference as far as possible in a parallel manner with regard to the control systems under consideration. Such as analysis affords, particularly in its extension to the faults of the actual regulator, a deep insight into the mechanism of the regulator process.

  7. Automatic Fixture Planning


    Fixture planning is a crucial problem in the field of fixture design. In this paper, the research scope and research methods of the computer-aided fixture planning are presented. Based on positioning principles of typical workparts, an ANN algorithm, namely Hopfield algorithm, is adopted for the automatic fixture planning. Also, this paper leads a deep research into the selection of positioning and clamping surfaces (or points) on workparts using positioning-clamping-surface-selecting rules and matrix evaluation of deterministic workpart positioning. In the end of this paper, the methods to select positioning and clamping elements from database and the layout algorithm to assemble the selected fixture elements into a tangible fixture are developed.

  8. Evaluation of right and left ventricular function using speckle tracking echocardiography in patients with arrhythmogenic right ventricular cardiomyopathy and their first degree relatives

    Aneq Meriam


    Full Text Available Abstract Introduction and aim The identification of right ventricular abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC in early stages is still difficult. The aim of this study was to investigate if longitudinal strain based on speckle tracking can detect subtle right (RV or left ventricular (LV dysfunction as an early sign of ARVC. Methods and results Seventeen male patients, fulfilling Task force criteria for ARVC, 49 (32–70 years old, nineteen male first degree relatives 29 (19–73 y.o. and twenty-two healthy male volunteers 36 (24–66 y.o participated in the study. Twelve-lead and signal-averaged electrocardiograms were recorded. All subjects underwent echocardiography. LV and RV diameters, peak systolic velocity from tissue Doppler and longitudinal strain based on speckle tracking were measured from the basal and mid segments in both ventricles. RV longitudinal strain measurement was successful in first degree relatives and controls (95 resp. 86% but less feasible in patients (59%. Results were not systematically different between first degree relatives and controls. Using discriminant analysis, we then developed an index based on echocardiographic parameters. All normal controls had an index  Conclusion Longitudinal strain of LV and RV segments was significantly lower in patients than in relatives and controls. An index was developed incorporating dimensional and functional echocardiographic parameters. In combination with genetic testing this index might help to detect early phenotype expression in mutation carriers.

  9. Displasia arritmogénica del ventrículo derecho y enfermedad del nódulo sinusal Arrhythmogenic right ventricular dysplasia and sick sinus syndrome

    Domingo C. Balderramo


    Full Text Available La displasia arritmogénica del ventrículo derecho (DAVD compromete principalmente al ventrículo derecho y debe ser considerada en pacientes jóvenes que presentan síncope, taquicardia ventricular o paro cardíaco y en adultos con insuficiencia cardíaca congestiva. Las alteraciones eléctricas auriculares debidas a DAVD han sido poco descriptas. Informamos el caso de un varón de 60 años con DAVD que durante la evolución presentó enfermedad del nódulo sinusal (tiempo de recuperación del nódulo sinusal de 6113 mseg. Las arritmias auriculares se podrían explicar por el reemplazo gradual de los miocitos auriculares por tejido adiposo.Arrhythmogenic right ventricular dysplasia (ARVD involves primarily the right ventricle, and should be considered in young patients presenting with syncope, ventricular tachycardia, cardiac arrest or in adults patients with congestive heart failure. Atrial electrical abnormalities due to ARVD have been rarely described. We report a case of ARVD in a 60-year-old man who developed sick sinus syndrome during evolution (sinus node recovery time of 6113 mseg. Atrial arrhythmias may be explained by gradual replacement of right atrium myocytes by adipose tissue.

  10. A family with a complex clinical presentation characterized by arrhythmogenic right ventricular dysplasia/cardiomyopathy and features of branchio-oculo-facial syndrome.

    Murray, Brittney; Wagle, Rohan; Amat-Alarcon, Nuria; Wilkens, Alisha; Stephens, Paul; Zackai, Elaine H; Goldmuntz, Elizabeth; Calkins, Hugh; Deardorff, Matthew A; Judge, Daniel P


    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a familial form of cardiomyopathy typically caused by mutations in genes that encode an element of the cardiac desmosome. Branchio-oculo-facial syndrome (BOFS) is a craniofacial disorder caused by TFAP2A mutations. In a family segregating ARVD/C, some members also had features of BOFS. Genetic testing for ARVD/C identified a mutation in PKP2, encoding plakophilin-2, a component of the cardiac desmosome. Evaluation of dysmorphology by chromosome microarray (CMA) identified a 4.4 Mb deletion at chromosome 6p24 that included both TFAP2A and DSP, encoding desmoplakin, an additional component of the cardiac desmosome implicated in ARVD/C. A family member with both the 6p24 deletion and PKP2 mutation had more severe cardiac dysfunction. These findings suggest that this contiguous gene deletion contributes to both ARVD/C and BOFS, and that DSP haploinsufficiency may contribute to cardiomyopathy. This family provides a clinical example that underscores the need for careful evaluation in clinical scenarios where genetic heterogeneity is known to exist. Finally, it suggests that individuals with unexplained cardiomyopathy and dysmorphic facial features may benefit from CMA analysis.

  11. Prophylactic Antiarrhythmic Effect of Anesthetics at Subanesthetic Concentration on Epinephrine-Induced Arrhythmias in Rats after Brain Death

    Yuka Miyata


    Full Text Available The present study using brain death model of rats was designed to examine whether prophylactic administration of volatile anesthetics and propofol prevent the epinephrine-induced arrhythmias. A Fogarty catheter was placed intracranially for induction of brain death. After brain death, the rats were randomly assigned to five groups: the control group (no anesthetics, the sevoflurane group (0.8%, the isoflurane group (0.5%, the halothane group (0.3%, and the propofol group (195 μg·kg−1·min−1. These anesthetics were about 30% of ED50 of each anesthetic. The arrhythmogenic dose of epinephrine was determined in each anesthetic group. In addition, we examined left ventricular levels of connexin 43 phosphorylation 30 min after administration of each anesthetic with Western blot analysis. The arrhythmogenic dose of epinephrine in the sevoflurane group was significantly higher than that in the control group, while the arrhythmogenic dose of epinephrine in any other anesthetic group was not different. On the other hand, the ratio of phosphorylated-connexin 43/total connexin 43 was also similar among the study groups. Thus, prophylactic administration of subanesthetic dose of sevoflurane is effective in preventing epinephrine-induced arrhythmias after brain death, but phosphorylation of connexin is not involved in the antiarrhythmic property of sevoflurane.

  12. Prophylactic antiarrhythmic effect of anesthetics at subanesthetic concentration on epinephrine-induced arrhythmias in rats after brain death.

    Miyata, Yuka; Iwasaki, Mitsuo; Yamanaka, Hiroo; Sato, Masanori; Kamibayashi, Takahiko; Fujino, Yuji; Hayashi, Yukio


    The present study using brain death model of rats was designed to examine whether prophylactic administration of volatile anesthetics and propofol prevent the epinephrine-induced arrhythmias. A Fogarty catheter was placed intracranially for induction of brain death. After brain death, the rats were randomly assigned to five groups: the control group (no anesthetics), the sevoflurane group (0.8%), the isoflurane group (0.5%), the halothane group (0.3%), and the propofol group (195 μg·kg(-1) ·min(-1)). These anesthetics were about 30% of ED50 of each anesthetic. The arrhythmogenic dose of epinephrine was determined in each anesthetic group. In addition, we examined left ventricular levels of connexin 43 phosphorylation 30 min after administration of each anesthetic with Western blot analysis. The arrhythmogenic dose of epinephrine in the sevoflurane group was significantly higher than that in the control group, while the arrhythmogenic dose of epinephrine in any other anesthetic group was not different. On the other hand, the ratio of phosphorylated-connexin 43/total connexin 43 was also similar among the study groups. Thus, prophylactic administration of subanesthetic dose of sevoflurane is effective in preventing epinephrine-induced arrhythmias after brain death, but phosphorylation of connexin is not involved in the antiarrhythmic property of sevoflurane.

  13. Automatization and working memory capacity in schizophrenia.

    van Raalten, Tamar R; Ramsey, Nick F; Jansma, J Martijn; Jager, Gerry; Kahn, René S


    Working memory (WM) dysfunction in schizophrenia is characterized by inefficient WM recruitment and reduced capacity, but it is not yet clear how these relate to one another. In controls practice of certain cognitive tasks induces automatization, which is associated with reduced WM recruitment and increased capacity of concurrent task performance. We therefore investigated whether inefficient function and reduced capacity in schizophrenia was associated with a failure in automatization. FMRI data was acquired with a verbal WM task with novel and practiced stimuli in 18 schizophrenia patients and 18 controls. Participants performed a dual-task outside the scanner to test WM capacity. Patients showed intact performance on the WM task, which was paralleled by excessive WM activity. Practice improved performance and reduced WM activity in both groups. The difference in WM activity after practice predicted performance cost in controls but not in patients. In addition, patients showed disproportionately poor dual-task performance compared to controls, especially when processing information that required continuous adjustment in WM. Our findings support the notion of inefficient WM function and reduced capacity in schizophrenia. This was not related to a failure in automatization, but was evident when processing continuously changing information. This suggests that inefficient WM function and reduced capacity may be related to an inability to process information requiring frequent updating.

  14. Mental imagery affects subsequent automatic defense responses

    Muriel A Hagenaars


    Full Text Available Automatic defense responses promote survival and appropriate action under threat. They have also been associated with the development of threat-related psychiatric syndromes. Targeting such automatic responses during threat may be useful in populations with frequent threat exposure. Here, two experiments explored whether mental imagery as a pre-trauma manipulation could influence fear bradycardia (a core characteristic of freezing during subsequent analogue trauma (affective picture viewing. Image-based interventions have proven successful in the treatment of threat-related disorders, and are easily applicable. In Experiment 1 43 healthy participants were randomly assigned to an imagery script condition. Participants executed a passive viewing task with blocks of neutral, pleasant and unpleasant pictures after listening to an auditory script that was either related (with a positive or a negative outcome or unrelated to the unpleasant pictures from the passive viewing task. Heart rate was assessed during script listening and during passive viewing. Imagining negative related scripts resulted in greater bradycardia (neutral-unpleasant contrast than imagining positive scripts, especially unrelated. This effect was replicated in Experiment 2 (N = 51, again in the neutral-unpleasant contrast. An extra no-script condition showed that bradycardia was not induced by the negative related script, but rather that a positive script attenuated bradycardia. These preliminary results might indicate reduced vigilance after unrelated positive events. Future research should replicate these findings using a larger sample. Either way, the findings show that highly automatic defense behavior can be influenced by relatively simple mental imagery manipulations.

  15. Automatic Kurdish Dialects Identification

    Hossein Hassani


    Full Text Available Automatic dialect identification is a necessary Lan guage Technology for processing multi- dialect languages in which the dialects are linguis tically far from each other. Particularly, this becomes crucial where the dialects are mutually uni ntelligible. Therefore, to perform computational activities on these languages, the sy stem needs to identify the dialect that is the subject of the process. Kurdish language encompasse s various dialects. It is written using several different scripts. The language lacks of a standard orthography. This situation makes the Kurdish dialectal identification more interesti ng and required, both form the research and from the application perspectives. In this research , we have applied a classification method, based on supervised machine learning, to identify t he dialects of the Kurdish texts. The research has focused on two widely spoken and most dominant Kurdish dialects, namely, Kurmanji and Sorani. The approach could be applied to the other Kurdish dialects as well. The method is also applicable to the languages which are similar to Ku rdish in their dialectal diversity and differences.

  16. Automatic aircraft recognition

    Hmam, Hatem; Kim, Jijoong


    Automatic aircraft recognition is very complex because of clutter, shadows, clouds, self-occlusion and degraded imaging conditions. This paper presents an aircraft recognition system, which assumes from the start that the image is possibly degraded, and implements a number of strategies to overcome edge fragmentation and distortion. The current vision system employs a bottom up approach, where recognition begins by locating image primitives (e.g., lines and corners), which are then combined in an incremental fashion into larger sets of line groupings using knowledge about aircraft, as viewed from a generic viewpoint. Knowledge about aircraft is represented in the form of whole/part shape description and the connectedness property, and is embedded in production rules, which primarily aim at finding instances of the aircraft parts in the image and checking the connectedness property between the parts. Once a match is found, a confidence score is assigned and as evidence in support of an aircraft interpretation is accumulated, the score is increased proportionally. Finally a selection of the resulting image interpretations with the highest scores, is subjected to competition tests, and only non-ambiguous interpretations are allowed to survive. Experimental results demonstrating the effectiveness of the current recognition system are given.

  17. Electronic amplifiers for automatic compensators

    Polonnikov, D Ye


    Electronic Amplifiers for Automatic Compensators presents the design and operation of electronic amplifiers for use in automatic control and measuring systems. This book is composed of eight chapters that consider the problems of constructing input and output circuits of amplifiers, suppression of interference and ensuring high sensitivity.This work begins with a survey of the operating principles of electronic amplifiers in automatic compensator systems. The succeeding chapters deal with circuit selection and the calculation and determination of the principal characteristics of amplifiers, as

  18. The Automatic Telescope Network (ATN)

    Mattox, J R


    Because of the scheduled GLAST mission by NASA, there is strong scientific justification for preparation for very extensive blazar monitoring in the optical bands to exploit the opportunity to learn about blazars through the correlation of variability of the gamma-ray flux with flux at lower frequencies. Current optical facilities do not provide the required capability.Developments in technology have enabled astronomers to readily deploy automatic telescopes. The effort to create an Automatic Telescope Network (ATN) for blazar monitoring in the GLAST era is described. Other scientific applications of the networks of automatic telescopes are discussed. The potential of the ATN for science education is also discussed.

  19. Clothes Dryer Automatic Termination Evaluation

    TeGrotenhuis, Ward E.


    Volume 2: Improved Sensor and Control Designs Many residential clothes dryers on the market today provide automatic cycles that are intended to stop when the clothes are dry, as determined by the final remaining moisture content (RMC). However, testing of automatic termination cycles has shown that many dryers are susceptible to over-drying of loads, leading to excess energy consumption. In particular, tests performed using the DOE Test Procedure in Appendix D2 of 10 CFR 430 subpart B have shown that as much as 62% of the energy used in a cycle may be from over-drying. Volume 1 of this report shows an average of 20% excess energy from over-drying when running automatic cycles with various load compositions and dryer settings. Consequently, improving automatic termination sensors and algorithms has the potential for substantial energy savings in the U.S.

  20. Prospects for de-automatization.

    Kihlstrom, John F


    Research by Raz and his associates has repeatedly found that suggestions for hypnotic agnosia, administered to highly hypnotizable subjects, reduce or even eliminate Stroop interference. The present paper sought unsuccessfully to extend these findings to negative priming in the Stroop task. Nevertheless, the reduction of Stroop interference has broad theoretical implications, both for our understanding of automaticity and for the prospect of de-automatizing cognition in meditation and other altered states of consciousness.

  1. Process automatization in system administration

    Petauer, Janja


    The aim of the thesis is to present automatization of user management in company Studio Moderna. The company has grown exponentially in recent years, that is why we needed to find faster, easier and cheaper way of man- aging user accounts. We automatized processes of creating, changing and removing user accounts within Active Directory. We prepared user interface inside of existing application, used Java Script for drop down menus, wrote script in scripting programming langu...

  2. Automatic Sarcasm Detection: A Survey

    Joshi, Aditya; Bhattacharyya, Pushpak; Carman, Mark James


    Automatic sarcasm detection is the task of predicting sarcasm in text. This is a crucial step to sentiment analysis, considering prevalence and challenges of sarcasm in sentiment-bearing text. Beginning with an approach that used speech-based features, sarcasm detection has witnessed great interest from the sentiment analysis community. This paper is the first known compilation of past work in automatic sarcasm detection. We observe three milestones in the research so far: semi-supervised pat...

  3. Automatic Coarse Graining of Polymers

    Faller, Roland


    Several recently proposed semi--automatic and fully--automatic coarse--graining schemes for polymer simulations are discussed. All these techniques derive effective potentials for multi--atom units or super--atoms from atomistic simulations. These include techniques relying on single chain simulations in vacuum and self--consistent optimizations from the melt like the simplex method and the inverted Boltzmann method. The focus is on matching the polymer structure on different scales. Several ...

  4. The automatization of journalistic narrative

    Naara Normande


    Full Text Available This paper proposes an initial discussion about the production of automatized journalistic narratives. Despite being a topic discussed in specialized sites and international conferences in communication area, the concepts are still deficient in academic research. For this article, we studied the concepts of narrative, databases and algorithms, indicating a theoretical trend that explains this automatized journalistic narratives. As characterization, we use the cases of Los Angeles Times, Narrative Science and Automated Insights.

  5. Vaginismus and Dyspareunia : Automatic vs. Deliberate Disgust Responsivity

    Borg, Charmaine; de Jong, Peter J.; Schultz, Willibrord Weijmar


    Introduction. The difficulty of penetration experienced in vaginismus and dyspareunia may at least partly be due to a disgust-induced defensive response. Aims. To examine if sex stimuli specifically elicit: (i) automatic disgust-related memory associations; (ii) physiological disgust responsivity; a

  6. Conditioned craving cues elicit an automatic approach tendency

    D. van Gucht; D. Vansteenwegen; O. Van den Bergh; T. Beckers


    In two experiments, we used a Pavlovian differential conditioning procedure to induce craving for chocolate. As a result of repeated pairing with chocolate intake, initially neutral cues came to elicit an automatic approach tendency in a speeded stimulus-response compatibility reaction time task. Th

  7. Conditioned craving cues elicit an automatic approach tendency

    van Gucht, D.; Vansteenwegen, D.; Van den Bergh, O.; Beckers, T.


    In two experiments, we used a Pavlovian differential conditioning procedure to induce craving for chocolate. As a result of repeated pairing with chocolate intake, initially neutral cues came to elicit an automatic approach tendency in a speeded stimulus-response compatibility reaction time task.

  8. Recent advance in inherited arrhythmogenic disease-associated ion channelopathies%遗传性心律失常疾病相关离子通道病变的研究进展

    陈明颢; 胡峻岩


    Sudden cardiac death of young people is mainly caused by arrhythmia with genetic defects, which is called inherited arrhythmogenic diseases (IADs). The most common kinds of IADs are long QT syndrome (LQTS), short QT syndrome (SQTS), Brugada syndrome (BrS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Abnormal cardiac-electrical activities caused by the mutation of the subunit genes coding the ion channels in myocardial cells are the major cause of IADs. In this review, we focus on the advances in pathophysiological and genetic research of the channelopathies mentioned above.

  9. Missense mutations in Desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro

    Basso Cristina


    Full Text Available Abstract Background Mutations in genes encoding desmosomal proteins have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC, an autosomal dominant disease characterised by progressive myocardial atrophy with fibro-fatty replacement. We screened 54 ARVC probands for mutations in desmocollin-2 (DSC2, the only desmocollin isoform expressed in cardiac tissue. Methods Mutation screening was performed by denaturing high-performance liquid chromatography and direct sequencing. To evaluate the pathogenic potentials of the DSC2 mutations detected in patients affected with ARVC, full-length wild-type and mutated cDNAs were cloned in eukaryotic expression vectors to obtain a fusion protein with green fluorescence protein (GFP; constructs were transfected in neonatal rat cardiomyocytes and in HL-1 cells. Results We identified two heterozygous mutations (c.304G>A (p.E102K and c.1034T>C (p.I345T in two probands and in four family members. The two mutations p.E102K and p.I345T map to the N-terminal region, relevant to adhesive interactions. In vitro functional studies demonstrated that, unlike wild-type DSC2, the two N-terminal mutants are predominantly localised in the cytoplasm. Conclusion The two missense mutations in the N-terminal domain affect the normal localisation of DSC2, thus suggesting the potential pathogenic effect of the reported mutations. Identification of additional DSC2 mutations associated with ARVC may result in increased diagnostic accuracy with implications for genetic counseling.

  10. Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3.

    Kuhl, Angelika; Melberg, Atle; Meinl, Edgar; Nürnberg, Gudrun; Nürnberg, Peter; Kehrer-Sawatzki, Hildegard; Jenne, Dieter E


    Several years ago, autosomal dominant myofibrillar myopathy (MFM) in combination with arrhythmogenic right ventricular cardiomyopathy (ARVC7) was tentatively mapped to a 10.6-Mbp (million base pairs) region on chromosome 10q22.3 between D10S605 (78.9 Mbp) and D10S215 (89.5 Mbp) in a Swedish family assuming that ARVC7 was allelic with cardiomyopathy, dilated 1C (CMD1C). To date, neither the genetic defect in ARVC7 nor CMD1C has been reported. In a comprehensive follow-up study we re-examined and confirmed the previous linkage data for ARVC7 using a high-density single nucleotide polymorphism marker panel from Affymetrix (Human Mapping 10K Array). No other regions with significant evidence for linkage were discovered. The critical interval was narrowed down to 4.27 Mbp between D10S1645 and D10S1786. This reduced the total number of candidate genes to 18 of which 17 (RAI17, PPIF, C10ORF56, SFTPA1, SFTPA2, SFTPA1B, SFTPA2B, SFTPD, C10ORF57, PLAC9, ANXA11, MAT1A, DYDC1, DYDC2, C10ORF58, TSPAN14 and SH2D4B) are shared with the CMD1C region. No disease-causing mutation was found in their coding regions. Moreover, metavinculin (VCL) and ZASP/cypher (LDB3) proximal and distal to this linked region were excluded by sequence analysis. To search for submicroscopic and intragenic deletions by PCR, we generated hybrid cell lines carrying only the affected or normal chromosome 10 homolog. All sequence tagged sites and exons were present on both homologs. We speculate that regulatory mutations in 1 of the 18 genes from 10q22.3 are responsible for a heterogenous spectrum of clinically distinct myodegenerative disorders, affecting both skeletal and cardiac muscles to variable degrees.

  11. TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy.

    Vinayakumar Siragam

    Full Text Available Arrhythmogenic right ventricular cardiomyopathy (ARVC is a myocardial disease characterized by fibro-fatty replacement of myocardium in the right ventricular free wall and frequently results in life-threatening ventricular arrhythmias and sudden cardiac death. A heterozygous missense mutation in the transmembrane protein 43 (TMEM43 gene, p.S358L, has been genetically identified to cause autosomal dominant ARVC type 5 in a founder population from the island of Newfoundland, Canada. Little is known about the function of the TMEM43 protein or how it leads to the pathogenesis of ARVC. We sought to determine the distribution of TMEM43 and the effect of the p.S358L mutation on the expression and distribution of various intercalated (IC disc proteins as well as functional effects on IC disc gap junction dye transfer and conduction velocity in cell culture. Through Western blot analysis, transmission electron microscopy (TEM, immunofluorescence (IF, and electrophysiological analysis, our results showed that the stable expression of p.S358L mutation in the HL-1 cardiac cell line resulted in decreased Zonula Occludens (ZO-1 expression and the loss of ZO-1 localization to cell-cell junctions. Junctional Plakoglobin (JUP and α-catenin proteins were redistributed to the cytoplasm with decreased localization to cell-cell junctions. Connexin-43 (Cx43 phosphorylation was altered, and there was reduced gap junction dye transfer and conduction velocity in mutant TMEM43-transfected cells. These observations suggest that expression of the p.S358L mutant of TMEM43 found in ARVC type 5 may affect localization of proteins involved in conduction, alter gap junction function and reduce conduction velocity in cardiac tissue.

  12. Genotype-phenotype relationship in patients with arrhythmogenic right ventricular cardiomyopathy caused by desmosomal gene mutations: A systematic review and meta-analysis

    Xu, Zhenyan; Zhu, Wengen; Wang, Cen; Huang, Lin; Zhou, Qiongqiong; Hu, Jinzhu; Cheng, Xiaoshu; Hong, Kui


    The relationship between clinical phenotypes and desmosomal gene mutations in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is poorly characterized. Therefore, we performed a meta-analysis to explore the genotype-phenotype relationship in patients with ARVC. Any studies reporting this genotype-phenotype relationship were included. In total, 11 studies involving 1,113 patients were included. The presence of desmosomal gene mutations was associated with a younger onset age of ARVC (32.7 ± 15.2 versus 43.2 ± 13.3 years; P = 0.001), a higher incidence of T wave inversion in V1–3 leads (78.5% versus 51.6%; P = 0.0002) or a family history of ARVC (39.5% versus 27.1%; P = 0.03). There was no difference in the proportion of males between desmosomal-positive and desmosomal-negative patients (68.3% versus 68.9%; P = 0.60). The presence of desmosomal gene mutations was not associated with global or regional structural and functional alterations (63.5% versus 60.5%; P = 0.37), epsilon wave (29.4% versus 26.2%; P = 0.51) or ventricular tachycardia of left bundle-branch morphology (62.6% versus 57.2%; P = 0.30). Overall, patients with desmosomal gene mutations are characterized by an earlier onset age, a higher incidence of T wave inversion in V1–3 leads and a strong family history of ARVC. PMID:28120905

  13. Regional increase in extracellular potassium can be arrhythmogenic due to nonuniform muscle contraction in rat ventricular muscle

    Hattori, Taiki; Murai, Naomi; Nagano, Tsuyoshi; Nishio, Taichi; Boyden, Penelope A.; Shindoh, Chiyohiko


    In the ischemic myocardium, extracellular potassium ([K+]o) increases to ≥20 mmol/l. To determine how lethal arrhythmias occur during ischemia, we investigated whether the increased spatial pattern of [K+]o, i.e., a regional or a global increase, affects the incidence of arrhythmias. Force, sarcomere length, membrane potential, and nonuniform intracellular Ca2+ ([Ca2+]i) were measured in rat ventricular trabeculae. A “regional” or “global” increase in [K+]o was produced by exposing a restricted region of muscle to a jet of 30 mmol/l KCl or by superfusing trabeculae with a solution containing 30 mmol/l KCl, respectively. The increase in [Ca2+]i (CaCW) during Ca2+ waves was measured (24°C, 3.0 mmol/l [Ca2+]o). A regional increase in [K+]o caused nonuniform [Ca2+]i and contraction. In the presence of isoproterenol, the regional increase in [K+]o induced sustained arrhythmias in 10 of 14 trabeculae, whereas the global increase did not induce such arrhythmias. During sustained arrhythmias, Ca2+ surged within the jet-exposed region. In the absence of isoproterenol, the regional increase in [K+]o increased CaCW, whereas the global increase decreased it. This increase in CaCW with the regional increase in [K+]o was not suppressed by 100 μmol/l streptomycin, whereas it was suppressed by 1) a combination of 10 μmol/l cilnidipine and 3 μmol/l SEA0400; 2) 20 mmol/l 2,3-butanedione monoxime; and 3) 10 μmol/l blebbistatin. A regional but not a global increase in [K+]o induces sustained arrhythmias, probably due to nonuniform excitation-contraction coupling. The same mechanism may underlie arrhythmias during ischemia. PMID:22447939

  14. Restraint stress changes heart sensitivity to arrhythmogenic drugs%制动应激改变心脏对致心律失常药物的敏感性

    孙安阳; 李德兴; 王幼林; 李庆平


    AIM: To study the effects of acute restraint stress on ventricular electric stability (VES)and its mechanisms of action. METHODS:VES was evaluated both in vivo and in vitro by the changes of arrhythmogenic responses to icv or ip aconitine in rats and iv BaCl2 or adrenaline in rabbits following restraint stress for different durations. Pretreatments and the assay of heart-specific enzymes were made. RESULTS: The heart sensitivity to these drugs was promoted after stress for 2 h,but obtunded after stress for 8 h (the latency of ventricular arrhythmia to icv aconitine was shortened from 4. 1± 0. 9 min in control rats to 2.9±0. 9 min after stress for 2 h, P<0.05; but prolonged to 9.3± 3.8 min after stress for 8 h, P < 0.05). In Langendorff heart, the changes of VES induced by stress were similar to those in vivo, but to lesser degree. Pretreatment with adrenalectomy inhibited the descending phase of VES, while pretreatment with both aminophylline and vagotomy remarkably depressed the ascending phase at 8 h. In addition, the serum activities of lactate dehydrogenase (LDH), creatine kinase (CK), and aspartate aminotransferase and their isozymes, LDH1 and CK-MB, were elevated at 2 h, and rose continuously at 8 h.CONCLUSION: Acute restraint stress causes biphasic changes of VES. The initial decrease of VES was related to adrenal catecholamine release, whereasthe following increase of VES was ascribed to adaptive decrease of cAMP and vagal activation. The changes of VES did not always parallel the injury of heart.%目的:研究急性制动应激对心脏电稳定性的作用及机制.方法:应激后用icv或ip乌头碱及iv氯化钡或肾上腺素致心律失常反应的改变来评价在体及离体心脏电稳定性,施予预处理初步分析机制.结果:应激2 h促进药物性心律失常;应激8 h反而抑制之.icy乌头碱致心律失常的潜伏期在正常大鼠为4.1±0.9 min,但应激2 h后缩短至2.9±0.9 min,应激8 h后延长至9.3±3.8 min.该双

  15. Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model

    Hiroko Izumi-Nakaseko


    Full Text Available Since astemizole in an oral dose of 50 mg/kg/day was recently reported to exert anti-cancer effect in mice, we evaluated its proarrhythmic potential using the atrioventricular block dogs in order to clarify its cardiac safety profile. An oral dose of 3 mg/kg prolonged the QT interval without affecting the QTc (n = 4, whereas that of 30 mg/kg increased the short-term variability of repolarization and induced premature ventricular contractions in each animal, resulting in the onset of torsade de pointes in 1 animal (n = 4. Thus, proarrhythmic dose of astemizole would be lower than anti-cancer one, limiting its re-profiling as an anti-cancer drug.

  16. Influences of autonomic nervous system on atrial arrhythmogenic substrates and the incidence of atrial fibrillation in diabetic heart.

    Otake, Hideki; Suzuki, Hitoshi; Honda, Takashi; Maruyama, Yukio


    Diabetes mellitus (DM) is clinically associated with an increased incidence of atrial fibrillation (AF), but the underlying mechanism remains unclear. We hypothesized that neural remodeling enhances AF vulnerability in diabetic hearts. Eight weeks after creating streptozotocin-induced diabetic rats (DM rats) or control rats, the hearts were perfused according to the Langendorff method. Inducibility of AF was evaluated by 5 times burst pacing from the right atrium and the atrial effective refractory period (AERP) was measured. The protocol was repeated during sympathetic nerve stimulation (SNS) or parasympathetic nerve stimulation (PNS). In tissue samples taken from the right atrium, the density of nerves positive for tyrosine hydroxylase (TH) and acetylcholinesterase (AChE) were determined. SNS significantly increased the incidence of AF in DM rats (14 +/- 6 to 30 +/- 8%, P < 0.01), but not in control rats (11 +/- 4 to 14 +/- 6%, NS). Although AERP was significantly decreased by SNS in both rats (each P < 0.01), increased heterogeneity of AERP by SNS was seen only in DM rats. PNS significantly decreased AERP and increased the incidence of AF (9 +/- 5 to 30 +/- 5% in control rats, 12 +/- 6 to 27 +/- 6% in DM rats, each P < 0.01) in both rats. The density of TH-positive nerves was heterogeneous in DM rats compared with control rats, whereas the heterogeneity of AChE-positive nerves was not different in the rats. The prevalence of AF was enhanced by adrenergic activation in diabetic hearts, in which heterogeneous sympathetic innervation was evident. These results suggest that neural remodeling may play a crucial role for increased AF vulnerability in DM.

  17. Algorithms for skiascopy measurement automatization

    Fomins, Sergejs; Trukša, Renārs; KrūmiĆa, Gunta


    Automatic dynamic infrared retinoscope was developed, which allows to run procedure at a much higher rate. Our system uses a USB image sensor with up to 180 Hz refresh rate equipped with a long focus objective and 850 nm infrared light emitting diode as light source. Two servo motors driven by microprocessor control the rotation of semitransparent mirror and motion of retinoscope chassis. Image of eye pupil reflex is captured via software and analyzed along the horizontal plane. Algorithm for automatic accommodative state analysis is developed based on the intensity changes of the fundus reflex.

  18. Annual review in automatic programming

    Goodman, Richard


    Annual Review in Automatic Programming focuses on the techniques of automatic programming used with digital computers. Topics covered range from the design of machine-independent programming languages to the use of recursive procedures in ALGOL 60. A multi-pass translation scheme for ALGOL 60 is described, along with some commercial source languages. The structure and use of the syntax-directed compiler is also considered.Comprised of 12 chapters, this volume begins with a discussion on the basic ideas involved in the description of a computing process as a program for a computer, expressed in

  19. Automatic mapping of monitoring data

    Lophaven, Søren; Nielsen, Hans Bruun; Søndergaard, Jacob


    This paper presents an approach, based on universal kriging, for automatic mapping of monitoring data. The performance of the mapping approach is tested on two data-sets containing daily mean gamma dose rates in Germany reported by means of the national automatic monitoring network (IMIS......). In the second dataset an accidental release of radioactivity in the environment was simulated in the South-Western corner of the monitored area. The approach has a tendency to smooth the actual data values, and therefore it underestimates extreme values, as seen in the second dataset. However, it is capable...

  20. Automatic Construction of Finite Algebras



    This paper deals with model generation for equational theories,i.e.,automatically generating (finite)models of a given set of (logical) equations.Our method of finite model generation and a tool for automatic construction of finite algebras is described.Some examples are given to show the applications of our program.We argue that,the combination of model generators and theorem provers enables us to get a better understanding of logical theories.A brief comparison betwween our tool and other similar tools is also presented.

  1. Automatic Cataract Hardness Classification Ex Vivo by Ultrasound Techniques.

    Caixinha, Miguel; Santos, Mário; Santos, Jaime


    To demonstrate the feasibility of a new methodology for cataract hardness characterization and automatic classification using ultrasound techniques, different cataract degrees were induced in 210 porcine lenses. A 25-MHz ultrasound transducer was used to obtain acoustical parameters (velocity and attenuation) and backscattering signals. B-Scan and parametric Nakagami images were constructed. Ninety-seven parameters were extracted and subjected to a Principal Component Analysis. Bayes, K-Nearest-Neighbours, Fisher Linear Discriminant and Support Vector Machine (SVM) classifiers were used to automatically classify the different cataract severities. Statistically significant increases with cataract formation were found for velocity, attenuation, mean brightness intensity of the B-Scan images and mean Nakagami m parameter (p hardness characterization and automatic classification.

  2. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes

    Yusuke Kuroda


    Full Text Available Andersen-Tawil syndrome (ATS is a rare inherited channelopathy. The cardiac phenotype in ATS is typified by a prominent U wave and ventricular arrhythmia. An effective treatment for this disease remains to be established. We reprogrammed somatic cells from three ATS patients to generate induced pluripotent stem cells (iPSCs. Multi-electrode arrays (MEAs were used to record extracellular electrograms of iPSC-derived cardiomyocytes, revealing strong arrhythmic events in the ATS-iPSC-derived cardiomyocytes. Ca2+ imaging of cells loaded with the Ca2+ indicator Fluo-4 enabled us to examine intracellular Ca2+ handling properties, and we found a significantly higher incidence of irregular Ca2+ release in the ATS-iPSC-derived cardiomyocytes than in control-iPSC-derived cardiomyocytes. Drug testing using ATS-iPSC-derived cardiomyocytes further revealed that antiarrhythmic agent, flecainide, but not the sodium channel blocker, pilsicainide, significantly suppressed these irregular Ca2+ release and arrhythmic events, suggesting that flecainide's effect in these cardiac cells was not via sodium channels blocking. A reverse-mode Na+/Ca2+exchanger (NCX inhibitor, KB-R7943, was also found to suppress the irregular Ca2+ release, and whole-cell voltage clamping of isolated guinea-pig cardiac ventricular myocytes confirmed that flecainide could directly affect the NCX current (INCX. ATS-iPSC-derived cardiomyocytes recapitulate abnormal electrophysiological phenotypes and flecainide suppresses the arrhythmic events through the modulation of INCX.

  3. Automatic location of disruption times in JET.

    Moreno, R; Vega, J; Murari, A


    The loss of stability and confinement in tokamak plasmas can induce critical events known as disruptions. Disruptions produce strong electromagnetic forces and thermal loads which can damage fundamental components of the devices. Determining the disruption time is extremely important for various disruption studies: theoretical models, physics-driven models, or disruption predictors. In JET, during the experimental campaigns with the JET-C (Carbon Fiber Composite) wall, a common criterion to determine the disruption time consisted of locating the time of the thermal quench. However, with the metallic ITER-like wall (JET-ILW), this criterion is usually not valid. Several thermal quenches may occur previous to the current quench but the temperature recovers. Therefore, a new criterion has to be defined. A possibility is to use the start of the current quench as disruption time. This work describes the implementation of an automatic data processing method to estimate the disruption time according to this new definition. This automatic determination allows both reducing human efforts to locate the disruption times and standardizing the estimates (with the benefit of being less vulnerable to human errors).

  4. Automatic Validation of Protocol Narration

    Bodei, Chiara; Buchholtz, Mikael; Degano, Pierpablo;


    We perform a systematic expansion of protocol narrations into terms of a process algebra in order to make precise some of the detailed checks that need to be made in a protocol. We then apply static analysis technology to develop an automatic validation procedure for protocols. Finally, we...

  5. How CBO Estimates Automatic Stabilizers


    Medicare Payroll Taxes ........................................................................................ 10 Taxes on Production and Imports ...the economy. Most types of revenues—mainly personal, corporate, and social insurance taxes—are sensitive to the business cycle and account for most of...States: Automatic Stabilizers, Discretionary Fiscal Policy Actions, and the Economy, Finance and Economic Discussion Series Paper 2010-43 (Board of

  6. Automatic Identification of Metaphoric Utterances

    Dunn, Jonathan Edwin


    This dissertation analyzes the problem of metaphor identification in linguistic and computational semantics, considering both manual and automatic approaches. It describes a manual approach to metaphor identification, the Metaphoricity Measurement Procedure (MMP), and compares this approach with other manual approaches. The dissertation then…

  7. Automatic Error Analysis Using Intervals

    Rothwell, E. J.; Cloud, M. J.


    A technique for automatic error analysis using interval mathematics is introduced. A comparison to standard error propagation methods shows that in cases involving complicated formulas, the interval approach gives comparable error estimates with much less effort. Several examples are considered, and numerical errors are computed using the INTLAB…

  8. Trevi Park: Automatic Parking System

    ECT Team, Purdue


    TreviPark is an underground, multi-story stacking system that holds cars efficiently, thus reducing the cost of each parking space, as a fully automatic parking system intended to maximize space utilization in parking structures. TreviPark costs less than the price of a conventional urban garage and takes up half the volume and 80% of the depth.

  9. Automatic agar tray inoculation device

    Wilkins, J. R.; Mills, S. M.


    Automatic agar tray inoculation device is simple in design and foolproof in operation. It employs either conventional inoculating loop or cotton swab for uniform inoculation of agar media, and it allows technician to carry on with other activities while tray is being inoculated.

  10. An Automatic Program Synthesis Bibliography.


    experimentation of the BIS system. Interna- tional Journal of Man-Machine Studies, 17:173-188, 1982. [67] A F Cardenas . Technology for automatic...Philadelphia, PA, May 1978. [110] B L Gates and J A van Hulzen. Proceedings of European Conference on Computer Algebra (EUROCAL 85), pages 583-584. Volume 203

  11. Automatic milking : a better understanding

    Meijering, A.; Hogeveen, H.; Koning, de C.J.A.M.


    In 2000 the book Robotic Milking, reflecting the proceedings of an International Symposium which was held in The Netherlands came out. At that time, commercial introduction of automatic milking systems was no longer obstructed by technological inadequacies. Particularly in a few west-European countr

  12. Dynamic conduction and repolarisation changes in early arrhythmogenic right ventricular cardiomyopathy versus benign outflow tract ectopy demonstrated by high density mapping & paced surface ECG analysis.

    Malcolm C Finlay

    Full Text Available AIMS: The concealed phase of arrhythmogenic right ventricular cardiomyopathy (ARVC may initially manifest electrophysiologically. No studies have examined dynamic conduction/repolarization kinetics to distinguish benign right ventricular outflow tract ectopy (RVOT ectopy from ARVC's early phase. We investigated dynamic endocardial electrophysiological changes that differentiate early ARVC disease expression from RVOT ectopy. METHODS: 22 ARVC (12 definite based upon family history and mutation carrier status, 10 probable patients without right ventricular structural anomalies underwent high-density non-contact mapping of the right ventricle. These were compared to data from 14 RVOT ectopy and 12 patients with supraventricular tachycardias and normal hearts. Endocardial & surface ECG conduction and repolarization parameters were assessed during a standard S1-S2 restitution protocol. RESULTS: Definite ARVC without RV structural disease could not be clearly distinguished from RVOT ectopy during sinus rhythm or during steady state pacing. Delay in Activation Times at coupling intervals just above the ventricular effective refractory period (VERP increased in definite ARVC (43 ± 20 ms more than RVOT ectopy patients (36 ± 14 ms, p = 0.03 or Normals (25 ± 16 ms, p = 0.008 and a progressive separation of the repolarisation time curves between groups existed. Repolarization time increases in the RVOT were also greatest in ARVC (definite ARVC: 18 ± 20 ms; RVOT ectopy: 5 ± 14, Normal: 1 ± 18, p<0.05. Surface ECG correlates of these intracardiac measurements demonstrated an increase of greater than 48 ms in stimulus to surface ECG J-point pre-ERP versus steady state, with an 88% specificity and 68% sensitivity in distinguishing definite ARVC from the other groups. This technique could not distinguish patients with genetic predisposition to ARVC only (probable ARVC from controls. CONCLUSIONS: Significant changes in dynamic conduction and repolarization

  13. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy.

    Turkowski, Kari L; Tester, David J; Bos, J Martijn; Haugaa, Kristina H; Ackerman, Michael J


    Arrhythmogenic cardiomyopathy (ACM) is a heritable disease characterized by fibrofatty replacement of cardiomyocytes, has a prevalence of approximately 1 in 5000 individuals, and accounts for approximately 20% of sudden cardiac death in the young (≤35 years). ACM is most often inherited as an autosomal dominant trait with incomplete penetrance and variable expression. While mutations in several genes that encode key desmosomal proteins underlie about half of all ACM, the remainder is elusive genetically. Here, whole exome sequencing (WES) was performed with genomic triangulation in an effort to identify a novel explanation for a phenotype-positive, genotype-negative multi-generational pedigree with a presumed autosomal dominant, maternal inheritance of ACM. WES and genomic triangulation was performed on a symptomatic 14-year-old female proband, her affected mother and affected sister, and her unaffected father to elucidate a novel ACM-susceptibility gene for this pedigree. Following variant filtering using Ingenuity® Variant Analysis, gene priority ranking was performed on the candidate genes using ToppGene and Endeavour. The phylogenetic and physiochemical properties of candidate mutations were assessed further by 6 in silico prediction tools. Species alignment and amino acid conservation analysis was performed using the Uniprot Consortium. Tissue expression data was abstracted from Expression Atlas. Following WES and genomic triangulation, CDH2 emerged as a novel, autosomal dominant, ACM-susceptibility gene. The CDH2-encoded N-cadherin is a cell-cell adhesion protein predominately expressed in the heart. Cardiac dysfunction has been demonstrated in prior CDH2 knockout and over-expression animal studies. Further in silico mutation prediction, species conservation, and protein expression analysis supported the ultra-rare (minor allele frequency <0.005%) p.Asp407Asn-CDH2 variant as a likely pathogenic variant. Herein, it is demonstrated that genetic mutations in

  14. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis.

    Rou-Mu Hu

    Full Text Available SCN5A is a susceptibility gene for type 3 long QT syndrome, Brugada syndrome, and sudden infant death syndrome. INa dysfunction from mutated SCN5A can depend upon the splice variant background in which it is expressed and also upon environmental factors such as acidosis. S1787N was reported previously as a LQT3-associated mutation and has also been observed in 1 of 295 healthy white controls. Here, we determined the in vitro biophysical phenotype of SCN5A-S1787N in an effort to further assess its possible pathogenicity.We engineered S1787N in the two most common alternatively spliced SCN5A isoforms, the major isoform lacking a glutamine at position 1077 (Q1077del and the minor isoform containing Q1077, and expressed these two engineered constructs in HEK293 cells for electrophysiological study. Macroscopic voltage-gated INa was measured 24 hours after transfection with standard whole-cell patch clamp techniques. We applied intracellular solutions with pH7.4 or pH6.7. S1787N in the Q1077 background had WT-like INa including peak INa density, activation and inactivation parameters, and late INa amplitude in both pH 7.4 and pH 6.7. However, with S1787N in the Q1077del background, the percentages of INa late/peak were increased by 2.1 fold in pH 7.4 and by 2.9 fold in pH 6.7 when compared to WT.The LQT3-like biophysical phenotype for S1787N depends on both the SCN5A splice variant and on the intracellular pH. These findings provide further evidence that the splice variant and environmental factors affect the molecular phenotype of cardiac SCN5A-encoded sodium channel (Nav1.5, has implications for the clinical phenotype, and may provide insight into acidosis-induced arrhythmia mechanisms.

  15. Automatic Control System for Neutron Laboratory Safety

    ZHAO; Xiao; ZHANG; Guo-guang; FENG; Shu-qiang; SU; Dan; YANG; Guo-zhao; ZHANG; Shuai


    In order to cooperate with the experiment of neutron generator,and realize the automatic control in the experiment,a set of automatic control system for the safety of the neutron laboratory is designed.The system block diagram is shown as Fig.1.Automatic control device is for processing switch signal,so PLC is selected as the core component

  16. An Automatic Proof of Euler's Formula

    Jun Zhang


    Full Text Available In this information age, everything is digitalized. The encoding of functions and the automatic proof of functions are important. This paper will discuss the automatic calculation for Taylor expansion coefficients, as an example, it can be applied to prove Euler's formula automatically.

  17. Self-Compassion and Automatic Thoughts

    Akin, Ahmet


    The aim of this research is to examine the relationships between self-compassion and automatic thoughts. Participants were 299 university students. In this study, the Self-compassion Scale and the Automatic Thoughts Questionnaire were used. The relationships between self-compassion and automatic thoughts were examined using correlation analysis…

  18. 8 CFR 1205.1 - Automatic revocation.


    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Automatic revocation. 1205.1 Section 1205.1... REGULATIONS REVOCATION OF APPROVAL OF PETITIONS § 1205.1 Automatic revocation. (a) Reasons for automatic revocation. The approval of a petition or self-petition made under section 204 of the Act and in...

  19. 8 CFR 205.1 - Automatic revocation.


    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Automatic revocation. 205.1 Section 205.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REVOCATION OF APPROVAL OF PETITIONS § 205.1 Automatic revocation. (a) Reasons for automatic revocation. The approval of a petition...

  20. Automatic spikes detection in seismogram

    王海军; 靳平; 刘贵忠


    @@ Data processing for seismic network is very complex and fussy, because a lot of data is recorded in seismic network every day, which make it impossible to process these data all by manual work. Therefore, seismic data should be processed automatically to produce a initial results about events detection and location. Afterwards, these results are reviewed and modified by analyst. In automatic processing data quality checking is important. There are three main problem data thatexist in real seismic records, which include: spike, repeated data and dropouts. Spike is defined as isolated large amplitude point; the other two problem datahave the same features that amplitude of sample points are uniform in a interval. In data quality checking, the first step is to detect and statistic problem data in a data segment, if percent of problem data exceed a threshold, then the whole data segment is masked and not be processed in the later process.

  1. Automatic Schema Evolution in Root

    ReneBrun; FonsRademakers


    ROOT version 3(spring 2001) supports automatic class schema evolution.In addition this version also produces files that are self-describing.This is achieved by storing in each file a record with the description of all the persistent classes in the file.Being self-describing guarantees that a file can always be read later,its structure browsed and objects inspected.also when the library with the compiled code of these classes is missing The schema evolution mechanism supports the frequent case when multiple data sets generated with many different class versions must be analyzed in the same session.ROOT supports the automatic generation of C++ code describing the data objects in a file.

  2. Physics of Automatic Target Recognition

    Sadjadi, Firooz


    Physics of Automatic Target Recognition addresses the fundamental physical bases of sensing, and information extraction in the state-of-the art automatic target recognition field. It explores both passive and active multispectral sensing, polarimetric diversity, complex signature exploitation, sensor and processing adaptation, transformation of electromagnetic and acoustic waves in their interactions with targets, background clutter, transmission media, and sensing elements. The general inverse scattering, and advanced signal processing techniques and scientific evaluation methodologies being used in this multi disciplinary field will be part of this exposition. The issues of modeling of target signatures in various spectral modalities, LADAR, IR, SAR, high resolution radar, acoustic, seismic, visible, hyperspectral, in diverse geometric aspects will be addressed. The methods for signal processing and classification will cover concepts such as sensor adaptive and artificial neural networks, time reversal filt...

  3. Automatic design of magazine covers

    Jahanian, Ali; Liu, Jerry; Tretter, Daniel R.; Lin, Qian; Damera-Venkata, Niranjan; O'Brien-Strain, Eamonn; Lee, Seungyon; Fan, Jian; Allebach, Jan P.


    In this paper, we propose a system for automatic design of magazine covers that quantifies a number of concepts from art and aesthetics. Our solution to automatic design of this type of media has been shaped by input from professional designers, magazine art directors and editorial boards, and journalists. Consequently, a number of principles in design and rules in designing magazine covers are delineated. Several techniques are derived and employed in order to quantify and implement these principles and rules in the format of a software framework. At this stage, our framework divides the task of design into three main modules: layout of magazine cover elements, choice of color for masthead and cover lines, and typography of cover lines. Feedback from professional designers on our designs suggests that our results are congruent with their intuition.

  4. The Automatic Galaxy Collision Software

    Smith, Beverly J; Pfeiffer, Phillip; Perkins, Sam; Barkanic, Jason; Fritts, Steve; Southerland, Derek; Manchikalapudi, Dinikar; Baker, Matt; Luckey, John; Franklin, Coral; Moffett, Amanda; Struck, Curtis


    The key to understanding the physical processes that occur during galaxy interactions is dynamical modeling, and especially the detailed matching of numerical models to specific systems. To make modeling interacting galaxies more efficient, we have constructed the `Automatic Galaxy Collision' (AGC) code, which requires less human intervention in finding good matches to data. We present some preliminary results from this code for the well-studied system Arp 284 (NGC 7714/5), and address questions of uniqueness of solutions.

  5. Automatic computation of transfer functions

    Atcitty, Stanley; Watson, Luke Dale


    Technologies pertaining to the automatic computation of transfer functions for a physical system are described herein. The physical system is one of an electrical system, a mechanical system, an electromechanical system, an electrochemical system, or an electromagnetic system. A netlist in the form of a matrix comprises data that is indicative of elements in the physical system, values for the elements in the physical system, and structure of the physical system. Transfer functions for the physical system are computed based upon the netlist.

  6. Annual review in automatic programming

    Halpern, Mark I; Bolliet, Louis


    Computer Science and Technology and their Application is an eight-chapter book that first presents a tutorial on database organization. Subsequent chapters describe the general concepts of Simula 67 programming language; incremental compilation and conversational interpretation; dynamic syntax; the ALGOL 68. Other chapters discuss the general purpose conversational system for graphical programming and automatic theorem proving based on resolution. A survey of extensible programming language is also shown.

  7. Automatic Detection of Fake News

    Pérez-Rosas, Verónica; Kleinberg, Bennett; Lefevre, Alexandra; Mihalcea, Rada


    The proliferation of misleading information in everyday access media outlets such as social media feeds, news blogs, and online newspapers have made it challenging to identify trustworthy news sources, thus increasing the need for computational tools able to provide insights into the reliability of online content. In this paper, we focus on the automatic identification of fake content in online news. Our contribution is twofold. First, we introduce two novel datasets for the task of fake news...

  8. The Automatic Measurement of Targets

    Höhle, Joachim


    The automatic measurement of targets is demonstrated by means of a theoretical example and by an interactive measuring program for real imagery from a réseau camera. The used strategy is a combination of two methods: the maximum correlation coefficient and the correlation in the subpixel range. F...... interactive software is also part of a computer-assisted learning program on digital photogrammetry....

  9. Automatically-Programed Machine Tools

    Purves, L.; Clerman, N.


    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  10. Automatically-Programed Machine Tools

    Purves, L.; Clerman, N.


    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  11. Automatic translation among spoken languages

    Walter, Sharon M.; Costigan, Kelly


    The Machine Aided Voice Translation (MAVT) system was developed in response to the shortage of experienced military field interrogators with both foreign language proficiency and interrogation skills. Combining speech recognition, machine translation, and speech generation technologies, the MAVT accepts an interrogator's spoken English question and translates it into spoken Spanish. The spoken Spanish response of the potential informant can then be translated into spoken English. Potential military and civilian applications for automatic spoken language translation technology are discussed in this paper.

  12. The Mark II Automatic Diflux

    Jean L Rasson


    Full Text Available We report here on the new realization of an automatic fluxgate theodolite able to perform unattended absolute geomagnetic declination and inclination measurements: the AUTODIF MKII. The main changes of this version compared with the former one are presented as well as the better specifications we expect now. We also explain the absolute orientation procedure by means of a laser beam and a corner cube and the method for leveling the fluxgate sensor, which is different from a conventional DIflux theodolite.

  13. Automatic tracking sensor camera system

    Tsuda, Takao; Kato, Daiichiro; Ishikawa, Akio; Inoue, Seiki


    We are developing a sensor camera system for automatically tracking and determining the positions of subjects moving in three-dimensions. The system is intended to operate even within areas as large as soccer fields. The system measures the 3D coordinates of the object while driving the pan and tilt movements of camera heads, and the degree of zoom of the lenses. Its principal feature is that it automatically zooms in as the object moves farther away and out as the object moves closer. This maintains the area of the object as a fixed position of the image. This feature makes stable detection by the image processing possible. We are planning to use the system to detect the position of a soccer ball during a soccer game. In this paper, we describe the configuration of the developing automatic tracking sensor camera system. We then give an analysis of the movements of the ball within images of games, the results of experiments on method of image processing used to detect the ball, and the results of other experiments to verify the accuracy of an experimental system. These results show that the system is sufficiently accurate in terms of obtaining positions in three-dimensions.

  14. Arrhythmogenic effects of energy drinks.

    Enriquez, Andres; Frankel, David S


    Energy drinks (ED) are increasingly popular, especially among adolescents and young adults. They are marketed as enhancers of energy, alertness, and physical performance. ED contain high doses of caffeine and other active ingredients. Their safety has come under question due to reports temporally linking ED consumption with serious cardiovascular events, including arrhythmias and sudden cardiac death. In this article, we report 2 cases of life-threatening ventricular arrhythmias in young patients after consuming ED. We also review the ingredients of ED, the physiologic effects on the cardiovascular system, and the available evidence suggesting arrhythmogenecity. © 2017 Wiley Periodicals, Inc.

  15. ATIPICIDADES EN UN CASO CON DISPLASIA ARRITMOGÉNICA DEL VENTRÍCULO DERECHO O ENFERMEDAD DE UHL / Report of an atypical case with arrhythmogenic right ventricular dysplasia or Uhl´s anomaly

    Aníbal González Trujillo


    Full Text Available ResumenLa displasia arritmogénica del ventrículo derecho es una miocardiopatía caracterizada por arritmias ventriculares malignas y anomalías estructurales progresivas, que afectan primariamente al ventrículo derecho. Se presenta por una sustitución progresiva parcial o masiva del miocardio por tejido adiposo o fibroadiposo. La enfermedad de Uhl puede ser una manifestación extrema y generalizada de la displasia arritmogénica del ventrículo derecho, trastorno congénito muy poco frecuente con ausencia de miocardio ventricular derecho, por lo que sus paredes son delgadas como el papel. Se comenta el caso de un paciente masculino de 56 años que presentó pérdida de conocimiento y se le realizó el diagnóstico clínico y ecocardiográfico. Se discuten las características clínicas, el diagnóstico y la conducta a seguir ante esta cardiopatía potencialmente letal en pacientes que sufren síncope, taquicardia ventricular o parada cardíaca. / AbstractArrhythmogenic right ventricular dysplasia is a cardiomyopathy characterized by malignant ventricular arrhythmias and progressive structural abnormalities, affecting primarily the right ventricle. It appears due to a partial or massive progressive replacement of the myocardium by fibroadipose or adipose tissue. Uhl's disease may be an extreme and widespread manifestation of arrhythmogenic right ventricular dysplasia, a rare congenital disorder with absence of right ventricular myocardium, so that its walls are paper thin. The case of a 56 year old male patient who had loss of consciousness and underwent clinical and echocardiographic diagnosis is presented. The clinical features, diagnosis and action to take against this potentially fatal heart disease in patients with syncope, ventricular tachycardia or cardiac arrest are discussed.

  16. Automatic seagrass pattern identification on sonar images

    Rahnemoonfar, Maryam; Rahman, Abdullah


    Natural and human-induced disturbances are resulting in degradation and loss of seagrass. Freshwater flooding, severe meteorological events and invasive species are among the major natural disturbances. Human-induced disturbances are mainly due to boat propeller scars in the shallow seagrass meadows and anchor scars in the deeper areas. Therefore, there is a vital need to map seagrass ecosystems in order to determine worldwide abundance and distribution. Currently there is no established method for mapping the pothole or scars in seagrass. One of the most precise sensors to map the seagrass disturbance is side scan sonar. Here we propose an automatic method which detects seagrass potholes in sonar images. Side scan sonar images are notorious for having speckle noise and uneven illumination across the image. Moreover, disturbance presents complex patterns where most segmentation techniques will fail. In this paper, by applying mathematical morphology technique and calculating the local standard deviation of the image, the images were enhanced and the pothole patterns were identified. The proposed method was applied on sonar images taken from Laguna Madre in Texas. Experimental results show the effectiveness of the proposed method.

  17. Unification of automatic target tracking and automatic target recognition

    Schachter, Bruce J.


    The subject being addressed is how an automatic target tracker (ATT) and an automatic target recognizer (ATR) can be fused together so tightly and so well that their distinctiveness becomes lost in the merger. This has historically not been the case outside of biology and a few academic papers. The biological model of ATT∪ATR arises from dynamic patterns of activity distributed across many neural circuits and structures (including retina). The information that the brain receives from the eyes is "old news" at the time that it receives it. The eyes and brain forecast a tracked object's future position, rather than relying on received retinal position. Anticipation of the next moment - building up a consistent perception - is accomplished under difficult conditions: motion (eyes, head, body, scene background, target) and processing limitations (neural noise, delays, eye jitter, distractions). Not only does the human vision system surmount these problems, but it has innate mechanisms to exploit motion in support of target detection and classification. Biological vision doesn't normally operate on snapshots. Feature extraction, detection and recognition are spatiotemporal. When vision is viewed as a spatiotemporal process, target detection, recognition, tracking, event detection and activity recognition, do not seem as distinct as they are in current ATT and ATR designs. They appear as similar mechanism taking place at varying time scales. A framework is provided for unifying ATT and ATR.

  18. Annual review in automatic programming

    Goodman, Richard


    Annual Review in Automatic Programming, Volume 2 is a collection of papers that discusses the controversy about the suitability of COBOL as a common business oriented language, and the development of different common languages for scientific computation. A couple of papers describes the use of the Genie system in numerical calculation and analyzes Mercury autocode in terms of a phrase structure language, such as in the source language, target language, the order structure of ATLAS, and the meta-syntactical language of the assembly program. Other papers explain interference or an ""intermediate

  19. Automatic analysis of multiparty meetings

    Steve Renals


    This paper is about the recognition and interpretation of multiparty meetings captured as audio, video and other signals. This is a challenging task since the meetings consist of spontaneous and conversational interactions between a number of participants: it is a multimodal, multiparty, multistream problem. We discuss the capture and annotation of the Augmented Multiparty Interaction (AMI) meeting corpus, the development of a meeting speech recognition system, and systems for the automatic segmentation, summarization and social processing of meetings, together with some example applications based on these systems.

  20. Annual review in automatic programming

    Goodman, Richard


    Annual Review in Automatic Programming, Volume 4 is a collection of papers that deals with the GIER ALGOL compiler, a parameterized compiler based on mechanical linguistics, and the JOVIAL language. A couple of papers describes a commercial use of stacks, an IBM system, and what an ideal computer program support system should be. One paper reviews the system of compilation, the development of a more advanced language, programming techniques, machine independence, and program transfer to other machines. Another paper describes the ALGOL 60 system for the GIER machine including running ALGOL pro

  1. Automatic Inference of DATR Theories

    Barg, P


    This paper presents an approach for the automatic acquisition of linguistic knowledge from unstructured data. The acquired knowledge is represented in the lexical knowledge representation language DATR. A set of transformation rules that establish inheritance relationships and a default-inference algorithm make up the basis components of the system. Since the overall approach is not restricted to a special domain, the heuristic inference strategy uses criteria to evaluate the quality of a DATR theory, where different domains may require different criteria. The system is applied to the linguistic learning task of German noun inflection.

  2. Coordinated hybrid automatic repeat request

    Makki, Behrooz


    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  3. Commutated automatic gain control system

    Yost, S. R.


    The commutated automatic gain control (AGC) system was designed and built for the prototype Loran-C receiver is discussed. The current version of the prototype receiver, the Mini L-80, was tested initially in 1980. The receiver uses a super jolt microcomputer to control a memory aided phase loop (MAPLL). The microcomputer also controls the input/output, latitude/longitude conversion, and the recently added AGC system. The AGC control adjusts the level of each station signal, such that the early portion of each envelope rise is about at the same amplitude in the receiver envelope detector.

  4. On automatic machine translation evaluation

    Darinka Verdonik


    Full Text Available An important task of developing machine translation (MT is evaluating system performance. Automatic measures are most commonly used for this task, as manual evaluation is time-consuming and costly. However, to perform an objective evaluation is not a trivial task. Automatic measures, such as BLEU, TER, NIST, METEOR etc., have their own weaknesses, while manual evaluations are also problematic since they are always to some extent subjective. In this paper we test the influence of a test set on the results of automatic MT evaluation for the subtitling domain. Translating subtitles is a rather specific task for MT, since subtitles are a sort of summarization of spoken text rather than a direct translation of (written text. Additional problem when translating language pair that does not include English, in our example Slovene-Serbian, is that commonly the translations are done from English to Serbian and from English to Slovenian, and not directly, since most of the TV production is originally filmed in English. All this poses additional challenges to MT and consequently to MT evaluation. Automatic evaluation is based on a reference translation, which is usually taken from an existing parallel corpus and marked as a test set. In our experiments, we compare the evaluation results for the same MT system output using three types of test set. In the first round, the test set are 4000 subtitles from the parallel corpus of subtitles SUMAT. These subtitles are not direct translations from Serbian to Slovene or vice versa, but are based on an English original. In the second round, the test set are 1000 subtitles randomly extracted from the first test set and translated anew, from Serbian to Slovenian, based solely on the Serbian written subtitles. In the third round, the test set are the same 1000 subtitles, however this time the Slovene translations were obtained by manually correcting the Slovene MT outputs so that they are correct translations of the

  5. Automatic generation of tourist brochures

    Birsak, Michael


    We present a novel framework for the automatic generation of tourist brochures that include routing instructions and additional information presented in the form of so-called detail lenses. The first contribution of this paper is the automatic creation of layouts for the brochures. Our approach is based on the minimization of an energy function that combines multiple goals: positioning of the lenses as close as possible to the corresponding region shown in an overview map, keeping the number of lenses low, and an efficient numbering of the lenses. The second contribution is a route-aware simplification of the graph of streets used for traveling between the points of interest (POIs). This is done by reducing the graph consisting of all shortest paths through the minimization of an energy function. The output is a subset of street segments that enable traveling between all the POIs without considerable detours, while at the same time guaranteeing a clutter-free visualization. © 2014 The Author(s) Computer Graphics Forum © 2014 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

  6. ACIR: automatic cochlea image registration

    Al-Dhamari, Ibraheem; Bauer, Sabine; Paulus, Dietrich; Lissek, Friedrich; Jacob, Roland


    Efficient Cochlear Implant (CI) surgery requires prior knowledge of the cochlea's size and its characteristics. This information helps to select suitable implants for different patients. To get these measurements, a segmentation method of cochlea medical images is needed. An important pre-processing step for good cochlea segmentation involves efficient image registration. The cochlea's small size and complex structure, in addition to the different resolutions and head positions during imaging, reveals a big challenge for the automated registration of the different image modalities. In this paper, an Automatic Cochlea Image Registration (ACIR) method for multi- modal human cochlea images is proposed. This method is based on using small areas that have clear structures from both input images instead of registering the complete image. It uses the Adaptive Stochastic Gradient Descent Optimizer (ASGD) and Mattes's Mutual Information metric (MMI) to estimate 3D rigid transform parameters. The use of state of the art medical image registration optimizers published over the last two years are studied and compared quantitatively using the standard Dice Similarity Coefficient (DSC). ACIR requires only 4.86 seconds on average to align cochlea images automatically and to put all the modalities in the same spatial locations without human interference. The source code is based on the tool elastix and is provided for free as a 3D Slicer plugin. Another contribution of this work is a proposed public cochlea standard dataset which can be downloaded for free from a public XNAT server.

  7. QXT-full Automatic Saccharify Instrument


    QXT is a full automatic saccharify instrument of eight holes . The instrument use process control technology of micro-computer. It can realize automatic of saccharify full process correctly. Due to adapt control mode of high precision expert PID and digit automatic calibration technology of fill micro computer, not only ensure precision of linear raising temperature region (1 ℃ /min) and constant temperature region (temperature error ±0.2 ℃), but also overcome the disturbance

  8. Automatic Control of Water Pumping Stations

    Muhannad Alrheeh; JIANG Zhengfeng


    Automatic Control of pumps is an interesting proposal to operate water pumping stations among many kinds of water pumping stations according to their functions.In this paper, our pumping station is being used for water supply system. This paper is to introduce the idea of pump controller and the important factors that must be considering when we want to design automatic control system of water pumping stations. Then the automatic control circuit with the function of all components will be introduced.

  9. Automatic Discovery of Non-Compositional Compounds in Parallel Data

    Melamed, I D


    Automatic segmentation of text into minimal content-bearing units is an unsolved problem even for languages like English. Spaces between words offer an easy first approximation, but this approximation is not good enough for machine translation (MT), where many word sequences are not translated word-for-word. This paper presents an efficient automatic method for discovering sequences of words that are translated as a unit. The method proceeds by comparing pairs of statistical translation models induced from parallel texts in two languages. It can discover hundreds of non-compositional compounds on each iteration, and constructs longer compounds out of shorter ones. Objective evaluation on a simple machine translation task has shown the method's potential to improve the quality of MT output. The method makes few assumptions about the data, so it can be applied to parallel data other than parallel texts, such as word spellings and pronunciations.

  10. Automatic computer-aided system of simulating solder joint formation

    Zhao, Xiujuan; Wang, Chunqing; Zheng, Guanqun; Wang, Gouzhong; Yang, Shiqin


    One critical aspect in electronic packaging is the fatigue/creep-induced failure in solder interconnections, which is found to be highly dependent on the shape of solder joints. Thus predicting and analyzing the solder joint shape is warranted. In this paper, an automatic computer-aided system is developed to simulate the formation of solder joint and analyze the influence of the different process parameters on the solder joint shape. The developed system is capable of visually designing the process parameters and calculating the solder joint shape automatically without any intervention from the user. The automation achieved will enable fast shape estimation with the variation of process parameters without time consuming experiments, and the simulating system provides the design and manufacturing engineers an efficient software tools to design soldering process in design environment. Moreover, a program developed from the system can serve as the preprocessor for subsequent finite element joint analysis program.

  11. Premature ventricular complex-induced chronic cough and cough syncope.

    Stec, S; Dabrowska, M; Zaborska, B; Bielicki, P; Maskey-Warzechowska, M; Tarnowski, W; Chazan, R; Kulakowski, P


    The present case study reports a case of chronic cough and cough syncope associated with frequent premature ventricular complexes (PVCs). Careful analysis of cough-related symptoms and ECG monitoring led to the suspicion of PVC-induced cough. A coincidence between PVCs and episodes of cough was also documented by a portable multichannel recorder. Moreover, Doppler echocardiography revealed a PVC-induced transient increase in the pulmonary artery blood flow. After exclusion of other possible aetiologies, complete relief of chronic cough and cough syncope was achieved by radiofrequency ablation of the arrhythmogenic focus located in the right ventricular outflow tract. Premature ventricular complexes should be considered as a cause of chronic cough and cough syncope and an interdisciplinary cooperation can lead to successful diagnosis and treatment of this condition.

  12. 致心律失常性右室心肌病21例临床分析%Clinical study on arrhythmogenic right ventricular vardiomyopathy



    目的 探讨致心律失常性右室心肌病(ARVC)的临床表现、心电图、影像学检查及治疗情况.方法 回顾性分析2007年至2014年收治的21例致心律失常性右室心肌病患者的资料,均符合2010年国际专家组《欧洲心脏杂志》再次修订的ARVC诊断标准,总结其临床特征及治疗情况.结果 21例患者主要表现为心悸、头晕、胸闷、气促者11例,心悸、反复晕厥者7例,窦房结功能障碍l例,体检发现右心增大2例,均出现室性心律失常,右胸导QRS平均间期大于左胸导,12例患者V1 ~3导出现Epsilon波,超声心动图及MRI示右心室增大,室壁局灶性变薄,心肌致密化不全,右室心尖部、流出道、前壁脂肪浸润,收缩功能减弱.8例导管射频消融患者即刻成功5例,2例置入ICD后产生有效放电干预,其余患者长期应用药物治疗.结论 ARVC临床表现无特异性,早期诊断困难,应提高疾病认识,综合分析家族史、临床表现、心电图及影像学检查等,选择合适治疗方法,提高诊疗效果.%Objective To investigate the clinical manifestation, electrocardiogram, imageological examination and treatment conditions of arrhythmogenic right ventricular vardiomyopathy(ARVC).Methods Retrospectively analyzed the clinical data of 21 patients with ARVC who were treated in the Fourth People' s Hospital of Shangqiu from February 2007 to March 2014.All of them conformed to ARVC diagnostic criteria which amended again by international expert group in "European Heart Journal" in 2010, and also summarized their clinical features and treatment conditions.Results Among the 21 cases, 11 patients had major performances with palpitation, dizzy giddy, chest congestion and anhelation, 7 patients with palpitation and recurrent syncope, 1 patient with sinus node dysfunction, and 2 patients with right heart enlargement though medical examination, all of them had the performance of ventricular arrhythmias.The QRS average period

  13. Autoclass: An automatic classification system

    Stutz, John; Cheeseman, Peter; Hanson, Robin


    The task of inferring a set of classes and class descriptions most likely to explain a given data set can be placed on a firm theoretical foundation using Bayesian statistics. Within this framework, and using various mathematical and algorithmic approximations, the AutoClass System searches for the most probable classifications, automatically choosing the number of classes and complexity of class descriptions. A simpler version of AutoClass has been applied to many large real data sets, has discovered new independently-verified phenomena, and has been released as a robust software package. Recent extensions allow attributes to be selectively correlated within particular classes, and allow classes to inherit, or share, model parameters through a class hierarchy. The mathematical foundations of AutoClass are summarized.

  14. Automatic quantification of iris color

    Christoffersen, S.; Harder, Stine; Andersen, J. D.


    An automatic algorithm to quantify the eye colour and structural information from standard hi-resolution photos of the human iris has been developed. Initially, the major structures in the eye region are identified including the pupil, iris, sclera, and eyelashes. Based on this segmentation...... regions. The result is a blue-brown ratio for each eye. Furthermore, an image clustering approach has been used with promising results. The approach is based on using a sparse dictionary of feature vectors learned from a training set of iris regions. The feature vectors contain both local structural...... is completely data driven and it can divide a group of eye images into classes based on structure, colour or a combination of the two. The methods have been tested on a large set of photos with promising results....

  15. Automatic Image Interpolation Using Homography

    Chi-Tsung Liu


    Full Text Available While taking photographs, we often face the problem that unwanted foreground objects (e.g., vehicles, signs, and pedestrians occlude the main subject(s. We propose to apply image interpolation (also known as inpainting techniques to remove unwanted objects in the photographs and to automatically patch the vacancy after the unwanted objects are removed. When given only a single image, if the information loss after the unwanted objects in images being removed is too great, the patching results are usually unsatisfactory. The proposed inpainting techniques employ the homographic constraints in geometry to incorporate multiple images taken from different viewpoints. Our experiment results showed that the proposed techniques could effectively reduce process in searching for potential patches from multiple input images and decide the best patches for the missing regions.

  16. Automatic validation of numerical solutions

    Stauning, Ole


    This thesis is concerned with ``Automatic Validation of Numerical Solutions''. The basic theory of interval analysis and self-validating methods is introduced. The mean value enclosure is applied to discrete mappings for obtaining narrow enclosures of the iterates when applying these mappings...... is the possiblility to combine the three methods in an extremely flexible way. We examine some applications where this flexibility is very useful. A method for Taylor expanding solutions of ordinary differential equations is presented, and a method for obtaining interval enclosures of the truncation errors incurred...... with intervals as initial values. A modification of the mean value enclosure of discrete mappings is considered, namely the extended mean value enclosure which in most cases leads to even better enclosures. These methods have previously been described in connection with discretizing solutions of ordinary...

  17. Automatic summarising factors and directions

    Jones, K S


    This position paper suggests that progress with automatic summarising demands a better research methodology and a carefully focussed research strategy. In order to develop effective procedures it is necessary to identify and respond to the context factors, i.e. input, purpose, and output factors, that bear on summarising and its evaluation. The paper analyses and illustrates these factors and their implications for evaluation. It then argues that this analysis, together with the state of the art and the intrinsic difficulty of summarising, imply a nearer-term strategy concentrating on shallow, but not surface, text analysis and on indicative summarising. This is illustrated with current work, from which a potentially productive research programme can be developed.

  18. Automatic Network Reconstruction using ASP

    Ostrowski, Max; Durzinsky, Markus; Marwan, Wolfgang; Wagler, Annegret


    Building biological models by inferring functional dependencies from experimental data is an im- portant issue in Molecular Biology. To relieve the biologist from this traditionally manual process, various approaches have been proposed to increase the degree of automation. However, available ap- proaches often yield a single model only, rely on specific assumptions, and/or use dedicated, heuris- tic algorithms that are intolerant to changing circumstances or requirements in the view of the rapid progress made in Biotechnology. Our aim is to provide a declarative solution to the problem by ap- peal to Answer Set Programming (ASP) overcoming these difficulties. We build upon an existing approach to Automatic Network Reconstruction proposed by part of the authors. This approach has firm mathematical foundations and is well suited for ASP due to its combinatorial flavor providing a characterization of all models explaining a set of experiments. The usage of ASP has several ben- efits over the existing heuristic a...

  19. Automatic orientation correction for radiographs

    Luo, Hui; Luo, Jiebo; Wang, Xiaohui


    In picture archiving and communications systems (PACS), images need to be displayed in standardized ways for radiologists' interpretations. However, for most radiographs acquired by computed radiography (CR), digital radiography (DR), or digitized films, the image orientation is undetermined because of the variation of examination conditions and patient situations. To address this problem, an automatic orientation correction method is presented. It first detects the most indicative region for orientation in a radiograph, and then extracts a set of low-level visual features sensitive to rotation from the region. Based on these features, a trained classifier based on a support vector machine is employed to recognize the correct orientation of the radiograph and reorient it to a desired position. A large-scale experiment has been conducted on more than 12,000 radiographs covering a large variety of body parts and projections to validate the method. The overall performance is quite promising, with the success rate of orientation correction reaching 95.2%.

  20. Automatic cobb angle determination from radiographic images

    Sardjono, Tri Arief; Wilkinson, Michael H.F.; Veldhuizen, Albert G.; Ooijen, van Peter M.A.; Purnama, Ketut E.; Verkerke, Gijsbertus J.


    Study Design. Automatic measurement of Cobb angle in patients with scoliosis. Objective. To test the accuracy of an automatic Cobb angle determination method from frontal radiographical images. Summary of Background Data. Thirty-six frontal radiographical images of patients with scoliosis. Met

  1. Automatic Cobb Angle Determination From Radiographic Images

    Sardjono, Tri Arief; Wilkinson, Michael H. F.; Veldhuizen, Albert G.; van Ooijen, Peter M. A.; Purnama, Ketut E.; Verkerke, Gijsbertus J.


    Study Design. Automatic measurement of Cobb angle in patients with scoliosis. Objective. To test the accuracy of an automatic Cobb angle determination method from frontal radiographical images. Summary of Background Data. Thirty-six frontal radiographical images of patients with scoliosis. Methods.

  2. An Experiment in Automatic Hierarchical Document Classification.

    Garland, Kathleen


    Describes method of automatic document classification in which documents classed as QA by Library of Congress classification system were clustered at six thresholds by keyword using single link technique. Automatically generated clusters were compared to Library of Congress subclasses, and partial classified hierarchy was formed. Twelve references…

  3. Automatic cobb angle determination from radiographic images

    Sardjono, Tri Arief; Wilkinson, Michael H.F.; Veldhuizen, Albert G.; van Ooijen, Peter M.A.; Purnama, Ketut E.; Verkerke, Gijsbertus Jacob


    Study Design. Automatic measurement of Cobb angle in patients with scoliosis. Objective. To test the accuracy of an automatic Cobb angle determination method from frontal radiographical images. Summary of Background Data. Thirty-six frontal radiographical images of patients with scoliosis. Methods.

  4. Generalization versus Contextualization in Automatic Evaluation

    Gawronski, Bertram; Rydell, Robert J.; Vervliet, Bram; De Houwer, Jan


    Research has shown that automatic evaluations can be highly robust and difficult to change, highly malleable and easy to change, and highly context dependent. We tested a representational account of these disparate findings, which specifies the conditions under which automatic evaluations reflect (a) initially acquired information, (b)…

  5. Solar Powered Automatic Shrimp Feeding System

    Dindo T. Ani


    Full Text Available - Automatic system has brought many revolutions in the existing technologies. One among the technologies, which has greater developments, is the solar powered automatic shrimp feeding system. For instance, the solar power which is a renewable energy can be an alternative solution to energy crisis and basically reducing man power by using it in an automatic manner. The researchers believe an automatic shrimp feeding system may help solve problems on manual feeding operations. The project study aimed to design and develop a solar powered automatic shrimp feeding system. It specifically sought to prepare the design specifications of the project, to determine the methods of fabrication and assembly, and to test the response time of the automatic shrimp feeding system. The researchers designed and developed an automatic system which utilizes a 10 hour timer to be set in intervals preferred by the user and will undergo a continuous process. The magnetic contactor acts as a switch connected to the 10 hour timer which controls the activation or termination of electrical loads and powered by means of a solar panel outputting electrical power, and a rechargeable battery in electrical communication with the solar panel for storing the power. By undergoing through series of testing, the components of the modified system were proven functional and were operating within the desired output. It was recommended that the timer to be used should be tested to avoid malfunction and achieve the fully automatic system and that the system may be improved to handle changes in scope of the project.

  6. 7 CFR 58.418 - Automatic cheese making equipment.


    ... processing or packaging areas. (c) Automatic salter. The automatic salter shall be constructed of stainless.... The automatic salter shall be constructed so that it can be satisfactorily cleaned. The salting...

  7. Automatic graphene transfer system for improved material quality and efficiency

    Boscá, Alberto; Pedrós, Jorge; Martínez, Javier; Palacios, Tomás; Calle, Fernando


    In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible substrates but tend to induce mechanical damage in rigid ones. A new system that automatically transfers CVD graphene to an arbitrary target substrate has been developed. The process is based on the all-fluidic manipulation of the graphene to avoid mechanical damage, strain and contamination, and on the combination of capillary action and electrostatic repulsion between the graphene and its container to ensure a centered sample on top of the target substrate. The improved carrier mobility and yield of the automatically transferred graphene, as compared to that manually transferred, is demonstrated by the optical and electrical characterization of field-effect transistors fabricated on both materials. In particular, 70% higher mobility values, with a 30% decrease in the unintentional doping and a 10% strain reduction are achieved. The system has been developed for lab-scale transfer and proved to be scalable for industrial applications.

  8. A Hierarchy of Tree-Automatic Structures

    Finkel, Olivier


    We consider $\\omega^n$-automatic structures which are relational structures whose domain and relations are accepted by automata reading ordinal words of length $\\omega^n$ for some integer $n\\geq 1$. We show that all these structures are $\\omega$-tree-automatic structures presentable by Muller or Rabin tree automata. We prove that the isomorphism relation for $\\omega^2$-automatic (resp. $\\omega^n$-automatic for $n>2$) boolean algebras (respectively, partial orders, rings, commutative rings, non commutative rings, non commutative groups) is not determined by the axiomatic system ZFC. We infer from the proof of the above result that the isomorphism problem for $\\omega^n$-automatic boolean algebras, $n > 1$, (respectively, rings, commutative rings, non commutative rings, non commutative groups) is neither a $\\Sigma_2^1$-set nor a $\\Pi_2^1$-set. We obtain that there exist infinitely many $\\omega^n$-automatic, hence also $\\omega$-tree-automatic, atomless boolean algebras $B_n$, $n\\geq 1$, which are pairwise isomorp...

  9. Automatic Weather Station (AWS) Lidar

    Rall, Jonathan A.R.; Abshire, James B.; Spinhirne, James D.; Smith, David E. (Technical Monitor)


    An autonomous, low-power atmospheric lidar instrument is being developed at NASA Goddard Space Flight Center. This compact, portable lidar will operate continuously in a temperature controlled enclosure, charge its own batteries through a combination of a small rugged wind generator and solar panels, and transmit its data from remote locations to ground stations via satellite. A network of these instruments will be established by co-locating them at remote Automatic Weather Station (AWS) sites in Antarctica under the auspices of the National Science Foundation (NSF). The NSF Office of Polar Programs provides support to place the weather stations in remote areas of Antarctica in support of meteorological research and operations. The AWS meteorological data will directly benefit the analysis of the lidar data while a network of ground based atmospheric lidar will provide knowledge regarding the temporal evolution and spatial extent of Type la polar stratospheric clouds (PSC). These clouds play a crucial role in the annual austral springtime destruction of stratospheric ozone over Antarctica, i.e. the ozone hole. In addition, the lidar will monitor and record the general atmospheric conditions (transmission and backscatter) of the overlying atmosphere which will benefit the Geoscience Laser Altimeter System (GLAS). Prototype lidar instruments have been deployed to the Amundsen-Scott South Pole Station (1995-96, 2000) and to an Automated Geophysical Observatory site (AGO 1) in January 1999. We report on data acquired with these instruments, instrument performance, and anticipated performance of the AWS Lidar.

  10. Pattern-Driven Automatic Parallelization

    Christoph W. Kessler


    Full Text Available This article describes a knowledge-based system for automatic parallelization of a wide class of sequential numerical codes operating on vectors and dense matrices, and for execution on distributed memory message-passing multiprocessors. Its main feature is a fast and powerful pattern recognition tool that locally identifies frequently occurring computations and programming concepts in the source code. This tool also works for dusty deck codes that have been "encrypted" by former machine-specific code transformations. Successful pattern recognition guides sophisticated code transformations including local algorithm replacement such that the parallelized code need not emerge from the sequential program structure by just parallelizing the loops. It allows access to an expert's knowledge on useful parallel algorithms, available machine-specific library routines, and powerful program transformations. The partially restored program semantics also supports local array alignment, distribution, and redistribution, and allows for faster and more exact prediction of the performance of the parallelized target code than is usually possible.

  11. Automatic segmentation of psoriasis lesions

    Ning, Yang; Shi, Chenbo; Wang, Li; Shu, Chang


    The automatic segmentation of psoriatic lesions is widely researched these years. It is an important step in Computer-aid methods of calculating PASI for estimation of lesions. Currently those algorithms can only handle single erythema or only deal with scaling segmentation. In practice, scaling and erythema are often mixed together. In order to get the segmentation of lesions area - this paper proposes an algorithm based on Random forests with color and texture features. The algorithm has three steps. The first step, the polarized light is applied based on the skin's Tyndall-effect in the imaging to eliminate the reflection and Lab color space are used for fitting the human perception. The second step, sliding window and its sub windows are used to get textural feature and color feature. In this step, a feature of image roughness has been defined, so that scaling can be easily separated from normal skin. In the end, Random forests will be used to ensure the generalization ability of the algorithm. This algorithm can give reliable segmentation results even the image has different lighting conditions, skin types. In the data set offered by Union Hospital, more than 90% images can be segmented accurately.

  12. Automatic Assessment of Programming assignment

    Surendra Gupta


    Full Text Available In today’s world study of computer’s language is more important. Effective and good programming skills are need full all computer science students. They can be master in programming, only through intensive exercise practices. Due to day by day increasing number of students in the class, the assessment of programming exercises leads to extensive workload for teacher/instructor, particularly if it has to be carried out manually. In this paper, we propose an automatic assessment system for programming assignments, using verification program with random inputs. One of the most important properties of a program is that, it carries out its intended function. The intended function of a program or part of a program can be verified by using inverse function’s verification program. For checking intended functionality and evaluation of a program, we have used verification program. This assessment system has been tested on basic C programming courses, and results shows that it can work well in basic programming exercises, with some initial promising results

  13. Automatic Transmission Of Liquid Nitrogen

    Sumedh Mhatre


    Full Text Available Liquid Nitrogen is one of the major substance used as a chiller in industry such as Ice cream factory Milk Diary Storage of blood sample Blood Bank etc. It helps to maintain the required product at a lower temperature for preservation purpose. We cannot fully utilise the LN2 so practically if we are using 3.75 litre LN2 for a single day then around 12 of LN2 450 ml is wasted due to vaporisation. A pressure relief valve is provided to create a pressure difference. If there is no pressure difference between the cylinder carrying LN2 and its surrounding it will results in damage of container as well as wastage of LN2.Transmission of LN2 from TA55 to BA3 is carried manually .So care must be taken for the transmission of LN2 in order to avoid its wastage. With the help of this project concept the transmission of LN2 will be carried automatically so as to reduce the wastage of LN2 in case of manual operation.

  14. Automatic image cropping for republishing

    Cheatle, Phil


    Image cropping is an important aspect of creating aesthetically pleasing web pages and repurposing content for different web or printed output layouts. Cropping provides both the possibility of improving the composition of the image, and also the ability to change the aspect ratio of the image to suit the layout design needs of different document or web page formats. This paper presents a method for aesthetically cropping images on the basis of their content. Underlying the approach is a novel segmentation-based saliency method which identifies some regions as "distractions", as an alternative to the conventional "foreground" and "background" classifications. Distractions are a particular problem with typical consumer photos found on social networking websites such as FaceBook, Flickr etc. Automatic cropping is achieved by identifying the main subject area of the image and then using an optimization search to expand this to form an aesthetically pleasing crop. Evaluation of aesthetic functions like auto-crop is difficult as there is no single correct solution. A further contribution of this paper is an automated evaluation method which goes some way towards handling the complexity of aesthetic assessment. This allows crop algorithms to be easily evaluated against a large test set.

  15. Corpus analysis and automatic detection of emotion-including keywords

    Yuan, Bo; He, Xiangqing; Liu, Ying


    Emotion words play a vital role in many sentiment analysis tasks. Previous research uses sentiment dictionary to detect the subjectivity or polarity of words. In this paper, we dive into Emotion-Inducing Keywords (EIK), which refers to the words in use that convey emotion. We first analyze an emotion corpus to explore the pragmatic aspects of EIK. Then we design an effective framework for automatically detecting EIK in sentences by utilizing linguistic features and context information. Our system outperforms traditional dictionary-based methods dramatically in increasing Precision, Recall and F1-score.

  16. Automatic Testing of a CANopen Node

    Liang, Hui


    This Bachelor’s thesis was commissioned by TK Engineering Oy in Vaasa. The goals of the thesis were to test a prototype CANopen node, called UWASA Node for conformance to the CiA 301 standard, and to develop the automatic performance test software and the automatic CiA 401 test software. A test report that describes to the designer what needs to be corrected and improved is made in this thesis. For the CiA 301 test there is a CANopen conformance test tool that can be used. The automatic perfo...

  17. An Automatic Clustering Technique for Optimal Clusters

    Pavan, K Karteeka; Rao, A V Dattatreya; 10.5121/ijcsea.2011.1412


    This paper proposes a simple, automatic and efficient clustering algorithm, namely, Automatic Merging for Optimal Clusters (AMOC) which aims to generate nearly optimal clusters for the given datasets automatically. The AMOC is an extension to standard k-means with a two phase iterative procedure combining certain validation techniques in order to find optimal clusters with automation of merging of clusters. Experiments on both synthetic and real data have proved that the proposed algorithm finds nearly optimal clustering structures in terms of number of clusters, compactness and separation.

  18. Tissue-resident Sca1+ PDGFRα+ mesenchymal progenitors are the cellular source of fibrofatty infiltration in arrhythmogenic cardiomyopathy [v1; ref status: indexed,

    Ben Paylor


    Full Text Available Arrhythmogenic cardiomyopathy (AC is a disease of the heart involving myocardial dystrophy leading to fibrofatty scarring of the myocardium and is associated with an increased risk of both ventricular arrhythmias and sudden cardiac death. It often affects the right ventricle but may also involve the left. Although there has been significant progress in understanding the role of underlying desmosomal genetic defects in AC, there is still a lack of data regarding the cellular processes involved in its progression. The development of cardiac fibrofatty scarring is known to be a principal pathological process associated with ventricular arrhythmias, and it is vital that we elucidate the role of various cell populations involved in the disease if targeted therapeutics are to be developed. The known role of mesenchymal progenitor cells in the reparative process of both the heart and skeletal muscle has provided inspiration for the identification of the cellular basis of fibrofatty infiltration in AC. Here we hypothesize that reparative processes triggered by myocardial degeneration lead to the differentiation of tissue-resident Sca1+ PDGFRα+ mesenchymal progenitors into adipocytes and fibroblasts, which compose the fibrofatty lesions characteristic of AC.

  19. Automatic thoracic body region localization

    Bai, PeiRui; Udupa, Jayaram K.; Tong, YuBing; Xie, ShiPeng; Torigian, Drew A.


    Radiological imaging and image interpretation for clinical decision making are mostly specific to each body region such as head & neck, thorax, abdomen, pelvis, and extremities. For automating image analysis and consistency of results, standardizing definitions of body regions and the various anatomic objects, tissue regions, and zones in them becomes essential. Assuming that a standardized definition of body regions is available, a fundamental early step needed in automated image and object analytics is to automatically trim the given image stack into image volumes exactly satisfying the body region definition. This paper presents a solution to this problem based on the concept of virtual landmarks and evaluates it on whole-body positron emission tomography/computed tomography (PET/CT) scans. The method first selects a (set of) reference object(s), segments it (them) roughly, and identifies virtual landmarks for the object(s). The geometric relationship between these landmarks and the boundary locations of body regions in the craniocaudal direction is then learned through a neural network regressor, and the locations are predicted. Based on low-dose unenhanced CT images of 180 near whole-body PET/CT scans (which includes 34 whole-body PET/CT scans), the mean localization error for the boundaries of superior of thorax (TS) and inferior of thorax (TI), expressed as number of slices (slice spacing ≍ 4mm)), and using either the skeleton or the pleural spaces as reference objects, is found to be 3,2 (using skeleton) and 3, 5 (using pleural spaces) respectively, or in mm 13, 10 mm (using skeleton) and 10.5, 20 mm (using pleural spaces), respectively. Improvements of this performance via optimal selection of objects and virtual landmarks and other object analytics applications are currently being pursued. and the skeleton and pleural spaces used as a reference objects

  20. Automatic tuning of myoelectric prostheses.

    Bonivento, C; Davalli, A; Fantuzzi, C; Sacchetti, R; Terenzi, S


    This paper is concerned with the development of a software package for the automatic tuning of myoelectric prostheses. The package core consists of Fuzzy Logic Expert Systems (FLES) that embody skilled operator heuristics in the tuning of prosthesis control parameters. The prosthesis system is an artificial arm-hand system developed at the National Institute of Accidents at Work (INAIL) laboratories. The prosthesis is powered by an electric motor that is controlled by a microprocessor using myoelectric signals acquired from skin-surface electrodes placed on a muscle in the residual limb of the subject. The software package, Microprocessor Controlled Arm (MCA) Auto Tuning, is a tool for aiding both INAIL expert operators and unskilled persons in the controller parameter tuning procedure. Prosthesis control parameter setup and subsequent recurrent adjustments are fundamental for the correct working of the prosthesis, especially when we consider that myoelectric parameters may vary greatly with environmental modifications. The parameter adjustment requires the end-user to go to the manufacturer's laboratory for the control parameters setup because, generally, he/she does not have the necessary knowledge and instruments to do this at home. However, this procedure is not very practical and involves a waste of time for the technicians and uneasiness for the clients. The idea behind the MCA Auto Tuning package consists in translating technician expertise into an FLES knowledge database. The software interacts through a user-friendly graphic interface with an unskilled user, who is guided through a step-by-step procedure in the prosthesis parameter tuning that emulates the traditional expert-aided procedure. The adoption of this program on a large scale may yield considerable economic benefits and improve the service quality supplied to the users of prostheses. In fact, the time required to set the prosthesis parameters are remarkably reduced, as is the technician

  1. Automatization and familiarity in repeated checking

    Dek, Eliane C P; van den Hout, Marcel A.; Giele, Catharina L.; Engelhard, Iris M.


    Repeated checking paradoxically increases memory uncertainty. This study investigated the underlying mechanism of this effect. We hypothesized that as a result of repeated checking, familiarity with stimuli increases, and automatization of the checking procedure occurs, which should result in decrea

  2. Automatic Speech Segmentation Based on HMM

    M. Kroul


    Full Text Available This contribution deals with the problem of automatic phoneme segmentation using HMMs. Automatization of speech segmentation task is important for applications, where large amount of data is needed to process, so manual segmentation is out of the question. In this paper we focus on automatic segmentation of recordings, which will be used for triphone synthesis unit database creation. For speech synthesis, the speech unit quality is a crucial aspect, so the maximal accuracy in segmentation is needed here. In this work, different kinds of HMMs with various parameters have been trained and their usefulness for automatic segmentation is discussed. At the end of this work, some segmentation accuracy tests of all models are presented.

  3. Collapsible truss structure is automatically expandable


    Coil springs wound with maximum initial tension in a three-truss, closed loop structure form a collapsible truss structure. The truss automatically expands and provides excellent rigidity and close dimensional tolerance when expanded.

  4. Automatic coding of online collaboration protocols

    Erkens, Gijsbert; Janssen, J.J.H.M.


    An automatic coding procedure is described to determine the communicative functions of messages in chat discussions. Five main communicative functions are distinguished: argumentative (indicating a line of argumentation or reasoning), responsive (e.g., confirmations, denials, and answers), informati

  5. 2010 United States Automatic Identification System Database

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2010 United States Automatic Identification System Database contains vessel traffic data for planning purposes within the U.S. coastal waters. The database is...

  6. 12th Portuguese Conference on Automatic Control

    Soares, Filomena; Moreira, António


    The biennial CONTROLO conferences are the main events promoted by The CONTROLO 2016 – 12th Portuguese Conference on Automatic Control, Guimarães, Portugal, September 14th to 16th, was organized by Algoritmi, School of Engineering, University of Minho, in partnership with INESC TEC, and promoted by the Portuguese Association for Automatic Control – APCA, national member organization of the International Federation of Automatic Control – IFAC. The seventy-five papers published in this volume cover a wide range of topics. Thirty-one of them, of a more theoretical nature, are distributed among the first five parts: Control Theory; Optimal and Predictive Control; Fuzzy, Neural and Genetic Control; Modeling and Identification; Sensing and Estimation. The papers go from cutting-edge theoretical research to innovative control applications and show expressively how Automatic Control can be used to increase the well being of people. .

  7. Automatic Evolution of Molecular Nanotechnology Designs

    Globus, Al; Lawton, John; Wipke, Todd; Saini, Subhash (Technical Monitor)


    This paper describes strategies for automatically generating designs for analog circuits at the molecular level. Software maps out the edges and vertices of potential nanotechnology systems on graphs, then selects appropriate ones through evolutionary or genetic paradigms.

  8. Automatic lexical classification: bridging research and practice.

    Korhonen, Anna


    Natural language processing (NLP)--the automatic analysis, understanding and generation of human language by computers--is vitally dependent on accurate knowledge about words. Because words change their behaviour between text types, domains and sub-languages, a fully accurate static lexical resource (e.g. a dictionary, word classification) is unattainable. Researchers are now developing techniques that could be used to automatically acquire or update lexical resources from textual data. If successful, the automatic approach could considerably enhance the accuracy and portability of language technologies, such as machine translation, text mining and summarization. This paper reviews the recent and on-going research in automatic lexical acquisition. Focusing on lexical classification, it discusses the many challenges that still need to be met before the approach can benefit NLP on a large scale.

  9. Automaticity in social-cognitive processes.

    Bargh, John A; Schwader, Kay L; Hailey, Sarah E; Dyer, Rebecca L; Boothby, Erica J


    Over the past several years, the concept of automaticity of higher cognitive processes has permeated nearly all domains of psychological research. In this review, we highlight insights arising from studies in decision-making, moral judgments, close relationships, emotional processes, face perception and social judgment, motivation and goal pursuit, conformity and behavioral contagion, embodied cognition, and the emergence of higher-level automatic processes in early childhood. Taken together, recent work in these domains demonstrates that automaticity does not result exclusively from a process of skill acquisition (in which a process always begins as a conscious and deliberate one, becoming capable of automatic operation only with frequent use) - there are evolved substrates and early childhood learning mechanisms involved as well.

  10. Automatic acquisition of pattern collocations in GO

    LIU Zhi-qing; DOU Qing; LI Wen-hong; LU Ben-jie


    The quality, quantity, and consistency of the knowledgeused in GO-playing programs often determine their strengths,and automatic acquisition of large amounts of high-quality andconsistent GO knowledge is crucial for successful GO playing.In a previous article of this subject, we have presented analgorithm for efficient and automatic acquisition of spatialpatterns of GO as well as their frequency of occurrence fromgame records. In this article, we present two algorithms, one forefficient and automatic acquisition of pairs of spatial patternsthat appear jointly in a local context, and the other for deter-mining whether the joint pattern appearances are of certainsignificance statistically and not just a coincidence. Results ofthe two algorithms include 1 779 966 pairs of spatial patternsacquired automatically from 16 067 game records of profess-sional GO players, of which about 99.8% are qualified as patterncollocations with a statistical confidence of 99.5% or higher.

  11. 2014 United States Automatic Identification System Database

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2014 United States Automatic Identification System Database contains vessel traffic data for planning purposes within the U.S. coastal waters. The database is...

  12. Natural language processing techniques for automatic test ...

    Journal of Computer Science and Its Application ... The questions were generated by first extracting the text from the materials supplied by the ... Keywords: Discourse Connectives, Machine Learning, Automatic Test Generation E-Learning.

  13. Automatic identification for standing tree limb pruning

    Sun Renshan; Li Wenbin; Tian Yongchen; Hua Li


    To meet the demand of automatic pruning machines,this paper presents a new method for dynamic automatic identification of standing tree limbs and capture of the digital images of Platycladus orientalis.Methods of computer vision,image processing and wavelet analysis technology were used to compress,filter,segment,abate noise and capture the outline of the picture.We then present the arithmetic for dynamic automatic identification of standing tree limbs,extracting basic growth characteristics of the standing trees such as the form,size,degree of bending and their relative spatial position.We use pattern recognition technology to confirm the proportionate relationship matching the database and thus achieve the goal of dynamic automatic identification of standing tree limbs.

  14. 2009 United States Automatic Identification System Database

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2009 United States Automatic Identification System Database contains vessel traffic data for planning purposes within the U.S. coastal waters. The database is...

  15. A Demonstration of Automatically Switched Optical Network


    We build an automatically switched optical network (ASON) testbed with four optical cross-connect nodes. Many fundamental ASON features are demonstrated, which is implemented by control protocols based on generalized multi-protocol label switching (GMPLS) framework.

  16. 2011 United States Automatic Identification System Database

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2011 United States Automatic Identification System Database contains vessel traffic data for planning purposes within the U.S. coastal waters. The database is...

  17. 2012 United States Automatic Identification System Database

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2012 United States Automatic Identification System Database contains vessel traffic data for planning purposes within the U.S. coastal waters. The database is...

  18. Automatic Classification of Interplanetary Dust Particles

    Lasue, J.; Stepinski, T. F.; Bell, S. W.


    We present an automatic classification of the IDPs collected by NASA-JSC based on their EDS spectra. Agglomerative clustering and the Sammon's map algorithms are used to visualize relationships between the clusters.

  19. Physiological role of endogenous amines in the modulation of ventricular automaticity in the guinea-pig.

    Hume, J; Katzung, B G


    1. Current-clamp experiments were carried out with guinea-pig papillary muscles to determine the dependence of depolarization-induced automaticity on endogenous catecholamines. 2. Catecholamine depletion was produced by pre-treatment of animals with 6-hydroxydopamine and confirmed by fluorimetric assay of right ventricular tissue. Papillary muscles from depleted animals demonstrated a marked suppression of depolarization-induced automaticity for maximum diastolic potentials less negative than -55 mV. This suppression was completely reversed by noradrenaline but not by tyramine. 3. In normal tissue, noradrenaline and tyramine had much smaller effects on automaticity arising from maximum diastolic potentials negative to -55 mV than on repetitive activity arising positive to this level. 4. L-propranolol in concentrations of 2-3 x 10(-7) M reduced repetitive activity in the less negative range of maximum diastolic potential. No evidence of direct membrane depression was observed at these doses and the effect was reversed by application of noradrenaline. 5. D-propranolol, the isomer with much lower beta-receptor blocking potency, required twentyfold higher concentrations to depress automaticity and this was accompanied by evidence of direct membrane depression, i.e. reduction of upstroke velocity of action potentials. 6. These results show that automaticity induced in guinea-pig papillary muscles by depolarization positive to -55 mV is strongly dependent upon endogenous catecholamines. 7. The hypothesis that endogenous catecholamines facilitate depolarization-induced automaticity through an increase in calcium conductance was modelled using numerical techniques. It was found that changes in calcium conductance caused changes in the model which closely parallelled the experimental effects of catecholamine depletion and beta-blockade. The effects of changes in delayed rectification in the model did not accurately reproduce the experimental results.

  20. Effects of bandwidth feedback on the automatization of an arm movement sequence.

    Agethen, Manfred; Krause, Daniel


    We examined the effects of a bandwidth feedback manipulation on motor learning. Effects on movement accuracy, as well as on movement consistency, have been addressed in earlier studies. We have additionally investigated the effects on motor automatization. Because providing error feedback is believed to induce attentional control processes, we suppose that a bandwidth method should facilitate motor automatization. Participants (N=48) were assigned to four groups: one control group and three intervention groups. Participants of the intervention groups practiced an arm movement sequence with 760 trials. The BW0-Group practiced with 100% frequency of feedback. For the BW10-Group, feedback was provided when the errors were larger than 10°. The YokedBW10-Group participants were matched to the feedback schedule of research twins from the BW10-Group. All groups performed pre-tests and retention tests with a secondary task paradigm to test for automaticity. The BW10-Group indicated a higher degree of automatization compared with the BW0-Group, which did not exhibit a change in automaticity. The comparison of the YokedBW10-Group, which also exhibited automatization, and the BW10-Group leads to the proposal that reduction of quantitative feedback frequency and additional positive feedback are responsible for the bandwidth effect. Differences in movement accuracy and consistency were not evident.

  1. Automatic Control of Freeboard and Turbine Operation

    Kofoed, Jens Peter; Frigaard, Peter Bak; Friis-Madsen, Erik;

    The report deals with the modules for automatic control of freeboard and turbine operation on board the Wave dragon, Nissum Bredning (WD-NB) prototype, and covers what has been going on up to ultimo 2003.......The report deals with the modules for automatic control of freeboard and turbine operation on board the Wave dragon, Nissum Bredning (WD-NB) prototype, and covers what has been going on up to ultimo 2003....

  2. Automatic Age Estimation System for Face Images

    Chin-Teng Lin; Dong-Lin Li; Jian-Hao Lai; Ming-Feng Han; Jyh-Yeong Chang


    Humans are the most important tracking objects in surveillance systems. However, human tracking is not enough to provide the required information for personalized recognition. In this paper, we present a novel and reliable framework for automatic age estimation based on computer vision. It exploits global face features based on the combination of Gabor wavelets and orthogonal locality preserving projections. In addition, the proposed system can extract face aging features automatically in rea...

  3. Automatic safety rod for reactors. [LMFBR

    Germer, J.H.


    An automatic safety rod for a nuclear reactor containing neutron absorbing material and designed to be inserted into a reactor core after a loss-of-flow. Actuation is based upon either a sudden decrease in core pressure drop or the pressure drop decreases below a predetermined minimum value. The automatic control rod includes a pressure regulating device whereby a controlled decrease in operating pressure due to reduced coolant flow does not cause the rod to drop into the core.

  4. Automatic Fringe Detection Of Dynamic Moire Patterns

    Fang, Jing; Su, Xian-ji; Shi, Hong-ming


    Fringe-carrier method is used in automatic fringe-order numbering of dynamic in-plane moire patterns. In experiment both static carrier and dynamic moire patterns are recorded. The image files corresponding to instants are set up to assign fringe orders automatically. Subtracting the carrier image from the modulated ones, the moire patterns due to the dynamic deformations are restored with fringe-order variation displayed by different grey levels.

  5. Automatic Text Summarization: Past, Present and Future

    Saggion, Horacio; Poibeau, Thierry


    International audience; Automatic text summarization, the computer-based production of condensed versions of documents, is an important technology for the information society. Without summaries it would be practically impossible for human beings to get access to the ever growing mass of information available online. Although research in text summarization is over fifty years old, some efforts are still needed given the insufficient quality of automatic summaries and the number of interesting ...

  6. Phoneme vs Grapheme Based Automatic Speech Recognition

    Magimai.-Doss, Mathew; Dines, John; Bourlard, Hervé; Hermansky, Hynek


    In recent literature, different approaches have been proposed to use graphemes as subword units with implicit source of phoneme information for automatic speech recognition. The major advantage of using graphemes as subword units is that the definition of lexicon is easy. In previous studies, results comparable to phoneme-based automatic speech recognition systems have been reported using context-independent graphemes or context-dependent graphemes with decision trees. In this paper, we study...

  7. Automatic quiz generation for elderly people

    Samuelsen, Jeanette


    Studies have indicated that games can be beneficial for the elderly, in areas such as cognitive functioning and well-being. Taking part in social activities, such as playing a game with others, could also be beneficial. One type of game is a computer-based quiz. One can create quiz questions manually; however, this can be time-consuming. Another approach is to generate quiz questions automatically. This project has examined how quizzes for Norwegian elderly can be automatically generated usin...

  8. UMLS-based automatic image indexing.

    Sneiderman, C; Sneiderman, Charles Alan; Demner-Fushman, D; Demner-Fushman, Dina; Fung, K W; Fung, Kin Wah; Bray, B; Bray, Bruce


    To date, most accurate image retrieval techniques rely on textual descriptions of images. Our goal is to automatically generate indexing terms for an image extracted from a biomedical article by identifying Unified Medical Language System (UMLS) concepts in image caption and its discussion in the text. In a pilot evaluation of the suggested image indexing method by five physicians, a third of the automatically identified index terms were found suitable for indexing.

  9. Automatic penalty continuation in structural topology optimization

    Rojas Labanda, Susana; Stolpe, Mathias


    this issue is addressed. We propose an automatic continuation method, where the material penalization parameter is included as a new variable in the problem and a constraint guarantees that the requested penalty is eventually reached. The numerical results suggest that this approach is an appealing...... alternative to continuation methods. Automatic continuation also generally obtains better designs than the classical formulation using a reduced number of iterations....

  10. Automatic Configuration of Programmable Logic Controller Emulators


    PLCs ), which are used to control much of the world’s critical infrastructures, are highly vulnerable and exposed to the Internet. Many efforts have...scalable solution is needed in order to automatically configure PLC emula- tors. The ScriptGenE Framework presented in this thesis leverages several...techniques used in reverse engineering protocols in order to automatically configure PLC emula- tors using network traces. The accuracy, flexibility, and

  11. Automatic terrain modeling using transfinite element analysis

    Collier, Nathaniel O.


    An automatic procedure for modeling terrain is developed based on L2 projection-based interpolation of discrete terrain data onto transfinite function spaces. The function space is refined automatically by the use of image processing techniques to detect regions of high error and the flexibility of the transfinite interpolation to add degrees of freedom to these areas. Examples are shown of a section of the Palo Duro Canyon in northern Texas.

  12. Automatic classification of endogenous landslide seismicity using the Random Forest supervised classifier

    Provost, F.; Hibert, C.; Malet, J.-P.


    The deformation of slow-moving landslides developed in clays induces endogenous seismicity of mostly low-magnitude events (MLAlps) for the detection of four types of seismic sources. The automatic algorithm retrieves 93% of sensitivity in comparison to a manually interpreted catalog considered as reference.

  13. 14 CFR 23.1329 - Automatic pilot system.


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 23.1329 Section 23...: Installation § 23.1329 Automatic pilot system. If an automatic pilot system is installed, it must meet the following: (a) Each system must be designed so that the automatic pilot can— (1) Be quickly and...

  14. Practical automatic Arabic license plate recognition system

    Mohammad, Khader; Agaian, Sos; Saleh, Hani


    Since 1970's, the need of an automatic license plate recognition system, sometimes referred as Automatic License Plate Recognition system, has been increasing. A license plate recognition system is an automatic system that is able to recognize a license plate number, extracted from image sensors. In specific, Automatic License Plate Recognition systems are being used in conjunction with various transportation systems in application areas such as law enforcement (e.g. speed limit enforcement) and commercial usages such as parking enforcement and automatic toll payment private and public entrances, border control, theft and vandalism control. Vehicle license plate recognition has been intensively studied in many countries. Due to the different types of license plates being used, the requirement of an automatic license plate recognition system is different for each country. [License plate detection using cluster run length smoothing algorithm ].Generally, an automatic license plate localization and recognition system is made up of three modules; license plate localization, character segmentation and optical character recognition modules. This paper presents an Arabic license plate recognition system that is insensitive to character size, font, shape and orientation with extremely high accuracy rate. The proposed system is based on a combination of enhancement, license plate localization, morphological processing, and feature vector extraction using the Haar transform. The performance of the system is fast due to classification of alphabet and numerals based on the license plate organization. Experimental results for license plates of two different Arab countries show an average of 99 % successful license plate localization and recognition in a total of more than 20 different images captured from a complex outdoor environment. The results run times takes less time compared to conventional and many states of art methods.

  15. Is phosphodiesterase inhibition arrhythmogenic? Electrophysiologic effects in pithed rats and in normoxic and hypoxic rabbit atria of enoximone, a new cardiotonic agent.

    Vaughan Williams, E M


    The positive inotropic and chronotropic actions of enoximone were confirmed. At concentrations within the clinical range, enoximone prolonged the chronotropic and hypotensive action of isoproterenol in pithed rats. Very high doses of both enoximone and isoproterenol caused ventricular fibrillation in only one of six rats. In isolated rabbit atria, the maximum frequency at which pacing stimuli were followed 1:1 was increased by enoximone, and atrial flutter was consistently induced, then terminated by greatly suprathreshold stimulation. Enoximone significantly shortened action potential duration (APD), but did not exacerbate the APD-shortening induced by hypoxia. Since such hypoxia-induced shortening occurred in the presence of glucose 11 mmol/L and oxygen 20%, it was concluded that it was unlikely to have been caused by the opening of ATP-regulated potassium channels. These animal experiments suggest that enoximone, at concentrations encountered clinically in humans, does not have any electrophysiologic actions that would be likely to increase the probability of arrhythmias.

  16. Automatic Defect Detection in X-Ray Images Using Image Data Fusion

    TIAN Yuan; DU Dong; CAI Guorui; WANG Li; ZHANG Hua


    Automatic defect detection in X-ray images is currently a focus of much research at home and abroad. The technology requires computerized image processing, image analysis, and pattern recognition. This paper describes an image processing method for automatic defect detection using image data fusion which synthesizes several methods including edge extraction, wave profile analyses, segmentation with dynamic threshold, and weld district extraction. Test results show that defects that induce an abrupt change over a predefined extent of the image intensity can be segmented regardless of the number, location, shape, or size. Thus, the method is more robust and practical than the current methods using only one method.

  17. Automaticity: Componential, Causal, and Mechanistic Explanations.

    Moors, Agnes


    The review first discusses componential explanations of automaticity, which specify non/automaticity features (e.g., un/controlled, un/conscious, non/efficient, fast/slow) and their interrelations. Reframing these features as factors that influence processes (e.g., goals, attention, and time) broadens the range of factors that can be considered (e.g., adding stimulus intensity and representational quality). The evidence reviewed challenges the view of a perfect coherence among goals, attention, and consciousness, and supports the alternative view that (a) these and other factors influence the quality of representations in an additive way (e.g., little time can be compensated by extra attention or extra stimulus intensity) and that (b) a first threshold of this quality is required for unconscious processing and a second threshold for conscious processing. The review closes with a discussion of causal explanations of automaticity, which specify factors involved in automatization such as repetition and complexity, and a discussion of mechanistic explanations, which specify the low-level processes underlying automatization.

  18. Automatic Fastening Large Structures: a New Approach

    Lumley, D. F.


    The external tank (ET) intertank structure for the space shuttle, a 27.5 ft diameter 22.5 ft long externally stiffened mechanically fastened skin-stringer-frame structure, was a labor intensitive manual structure built on a modified Saturn tooling position. A new approach was developed based on half-section subassemblies. The heart of this manufacturing approach will be 33 ft high vertical automatic riveting system with a 28 ft rotary positioner coming on-line in mid 1985. The Automatic Riveting System incorporates many of the latest automatic riveting technologies. Key features include: vertical columns with two sets of independently operating CNC drill-riveting heads; capability of drill, insert and upset any one piece fastener up to 3/8 inch diameter including slugs without displacing the workpiece offset bucking ram with programmable rotation and deep retraction; vision system for automatic parts program re-synchronization and part edge margin control; and an automatic rivet selection/handling system.

  19. Automatic computerized radiographic identification of cephalometric landmarks.

    Rudolph, D J; Sinclair, P M; Coggins, J M


    Computerized cephalometric analysis currently requires manual identification of landmark locations. This process is time-consuming and limited in accuracy. The purpose of this study was to develop and test a novel method for automatic computer identification of cephalometric landmarks. Spatial spectroscopy (SS) is a computerized method that identifies image structure on the basis of a convolution of the image with a set of filters followed by a decision method using statistical pattern recognition techniques. By this method, characteristic features are used to recognize anatomic structures. This study compared manual identification on a computer monitor and the SS automatic method for landmark identification on minimum resolution images (0.16 cm2 per pixel). Minimum resolution (defined as the lowest resolution at which a cephalometric structure could be identified) was used to reduce computational time and memory requirements during this development stage of the SS method. Fifteen landmarks were selected on a set of 14 test images. The results showed no statistical difference (p > 0.05) in mean landmark identification errors between manual identification on the computer display and automatic identification using SS. We conclude that SS shows potential for the automatic detection of landmarks, which is an important step in the development of a completely automatic cephalometric analysis.

  20. An Automatic Hierarchical Delay Analysis Tool

    FaridMheir-El-Saadi; BozenaKaminska


    The performance analysis of VLSI integrated circuits(ICs) with flat tools is slow and even sometimes impossible to complete.Some hierarchical tools have been developed to speed up the analysis of these large ICs.However,these hierarchical tools suffer from a poor interaction with the CAD database and poorly automatized operations.We introduce a general hierarchical framework for performance analysis to solve these problems.The circuit analysis is automatic under the proposed framework.Information that has been automatically abstracted in the hierarchy is kept in database properties along with the topological information.A limited software implementation of the framework,PREDICT,has also been developed to analyze the delay performance.Experimental results show that hierarchical analysis CPU time and memory requirements are low if heuristics are used during the abstraction process.

  1. Research on an Intelligent Automatic Turning System

    Lichong Huang


    Full Text Available Equipment manufacturing industry is the strategic industries of a country. And its core part is the CNC machine tool. Therefore, enhancing the independent research of relevant technology of CNC machine, especially the open CNC system, is of great significance. This paper presented some key techniques of an Intelligent Automatic Turning System and gave a viable solution for system integration. First of all, the integrated system architecture and the flexible and efficient workflow for perfoming the intelligent automatic turning process is illustrated. Secondly, the innovated methods of the workpiece feature recognition and expression and process planning of the NC machining are put forward. Thirdly, the cutting tool auto-selection and the cutting parameter optimization solution are generated with a integrated inference of rule-based reasoning and case-based reasoning. Finally, the actual machining case based on the developed intelligent automatic turning system proved the presented solutions are valid, practical and efficient.

  2. Automatic Age Estimation System for Face Images

    Chin-Teng Lin


    Full Text Available Humans are the most important tracking objects in surveillance systems. However, human tracking is not enough to provide the required information for personalized recognition. In this paper, we present a novel and reliable framework for automatic age estimation based on computer vision. It exploits global face features based on the combination of Gabor wavelets and orthogonal locality preserving projections. In addition, the proposed system can extract face aging features automatically in real‐time. This means that the proposed system has more potential in applications compared to other semi‐automatic systems. The results obtained from this novel approach could provide clearer insight for operators in the field of age estimation to develop real‐world applications.

  3. Towards unifying inheritance and automatic program specialization

    Schultz, Ulrik Pagh


    Inheritance allows a class to be specialized and its attributes refined, but implementation specialization can only take place by overriding with manually implemented methods. Automatic program specialization can generate a specialized, effcient implementation. However, specialization of programs...... and specialization of classes (inheritance) are considered different abstractions. We present a new programming language, Lapis, that unifies inheritance and program specialization at the conceptual, syntactic, and semantic levels. This paper presents the initial development of Lapis, which uses inheritance...... with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented...

  4. Automatic inference of indexing rules for MEDLINE

    Shooshan Sonya E


    Full Text Available Abstract Background: Indexing is a crucial step in any information retrieval system. In MEDLINE, a widely used database of the biomedical literature, the indexing process involves the selection of Medical Subject Headings in order to describe the subject matter of articles. The need for automatic tools to assist MEDLINE indexers in this task is growing with the increasing number of publications being added to MEDLINE. Methods: In this paper, we describe the use and the customization of Inductive Logic Programming (ILP to infer indexing rules that may be used to produce automatic indexing recommendations for MEDLINE indexers. Results: Our results show that this original ILP-based approach outperforms manual rules when they exist. In addition, the use of ILP rules also improves the overall performance of the Medical Text Indexer (MTI, a system producing automatic indexing recommendations for MEDLINE. Conclusion: We expect the sets of ILP rules obtained in this experiment to be integrated into MTI.

  5. Automatic Image-Based Pencil Sketch Rendering

    王进; 鲍虎军; 周伟华; 彭群生; 徐迎庆


    This paper presents an automatic image-based approach for converting greyscale images to pencil sketches, in which strokes follow the image features. The algorithm first extracts a dense direction field automatically using Logical/Linear operators which embody the drawing mechanism. Next, a reconstruction approach based on a sampling-and-interpolation scheme is introduced to generate stroke paths from the direction field. Finally, pencil strokes are rendered along the specified paths with consideration of image tone and artificial illumination.As an important application, the technique is applied to render portraits from images with little user interaction. The experimental results demonstrate that the approach can automatically achieve compelling pencil sketches from reference images.

  6. Support vector machine for automatic pain recognition

    Monwar, Md Maruf; Rezaei, Siamak


    Facial expressions are a key index of emotion and the interpretation of such expressions of emotion is critical to everyday social functioning. In this paper, we present an efficient video analysis technique for recognition of a specific expression, pain, from human faces. We employ an automatic face detector which detects face from the stored video frame using skin color modeling technique. For pain recognition, location and shape features of the detected faces are computed. These features are then used as inputs to a support vector machine (SVM) for classification. We compare the results with neural network based and eigenimage based automatic pain recognition systems. The experiment results indicate that using support vector machine as classifier can certainly improve the performance of automatic pain recognition system.

  7. Oocytes Polar Body Detection for Automatic Enucleation

    Di Chen


    Full Text Available Enucleation is a crucial step in cloning. In order to achieve automatic blind enucleation, we should detect the polar body of the oocyte automatically. The conventional polar body detection approaches have low success rate or low efficiency. We propose a polar body detection method based on machine learning in this paper. On one hand, the improved Histogram of Oriented Gradient (HOG algorithm is employed to extract features of polar body images, which will increase success rate. On the other hand, a position prediction method is put forward to narrow the search range of polar body, which will improve efficiency. Experiment results show that the success rate is 96% for various types of polar bodies. Furthermore, the method is applied to an enucleation experiment and improves the degree of automatic enucleation.

  8. Automatic weld torch guidance control system

    Smaith, H. E.; Wall, W. A.; Burns, M. R., Jr.


    A highly reliable, fully digital, closed circuit television optical, type automatic weld seam tracking control system was developed. This automatic tracking equipment is used to reduce weld tooling costs and increase overall automatic welding reliability. The system utilizes a charge injection device digital camera which as 60,512 inidividual pixels as the light sensing elements. Through conventional scanning means, each pixel in the focal plane is sequentially scanned, the light level signal digitized, and an 8-bit word transmitted to scratch pad memory. From memory, the microprocessor performs an analysis of the digital signal and computes the tracking error. Lastly, the corrective signal is transmitted to a cross seam actuator digital drive motor controller to complete the closed loop, feedback, tracking system. This weld seam tracking control system is capable of a tracking accuracy of + or - 0.2 mm, or better. As configured, the system is applicable to square butt, V-groove, and lap joint weldments.

  9. Semi-automatic knee cartilage segmentation

    Dam, Erik B.; Folkesson, Jenny; Pettersen, Paola C.; Christiansen, Claus


    Osteo-Arthritis (OA) is a very common age-related cause of pain and reduced range of motion. A central effect of OA is wear-down of the articular cartilage that otherwise ensures smooth joint motion. Quantification of the cartilage breakdown is central in monitoring disease progression and therefore cartilage segmentation is required. Recent advances allow automatic cartilage segmentation with high accuracy in most cases. However, the automatic methods still fail in some problematic cases. For clinical studies, even if a few failing cases will be averaged out in the overall results, this reduces the mean accuracy and precision and thereby necessitates larger/longer studies. Since the severe OA cases are often most problematic for the automatic methods, there is even a risk that the quantification will introduce a bias in the results. Therefore, interactive inspection and correction of these problematic cases is desirable. For diagnosis on individuals, this is even more crucial since the diagnosis will otherwise simply fail. We introduce and evaluate a semi-automatic cartilage segmentation method combining an automatic pre-segmentation with an interactive step that allows inspection and correction. The automatic step consists of voxel classification based on supervised learning. The interactive step combines a watershed transformation of the original scan with the posterior probability map from the classification step at sub-voxel precision. We evaluate the method for the task of segmenting the tibial cartilage sheet from low-field magnetic resonance imaging (MRI) of knees. The evaluation shows that the combined method allows accurate and highly reproducible correction of the segmentation of even the worst cases in approximately ten minutes of interaction.

  10. Automatic Target Detection Using Wavelet Transform

    Ganesan L


    Full Text Available Automatic target recognition (ATR involves processing images for detecting, classifying, and tracking targets embedded in a background scene. This paper presents an algorithm for detecting a specified set of target objects embedded in visual images for an ATR application. The developed algorithm employs a novel technique for automatically detecting man-made and non-man-made single, two, and multitargets from nontarget objects, located within a cluttered environment by evaluating nonoverlapping image blocks, where block-by-block comparison of wavelet cooccurrence feature is done. The results of the proposed algorithm are found to be satisfactory.

  11. Automatic Keyword Extraction from Individual Documents

    Rose, Stuart J.; Engel, David W.; Cramer, Nicholas O.; Cowley, Wendy E.


    This paper introduces a novel and domain-independent method for automatically extracting keywords, as sequences of one or more words, from individual documents. We describe the method’s configuration parameters and algorithm, and present an evaluation on a benchmark corpus of technical abstracts. We also present a method for generating lists of stop words for specific corpora and domains, and evaluate its ability to improve keyword extraction on the benchmark corpus. Finally, we apply our method of automatic keyword extraction to a corpus of news articles and define metrics for characterizing the exclusivity, essentiality, and generality of extracted keywords within a corpus.

  12. Automatic and strategic processes in advertising effects

    Grunert, Klaus G.


    , and can easily be adapted to situational circumstances. Both the perception of advertising and the way advertising influences brand evaluation involves both processes. Automatic processes govern the recognition of advertising stimuli, the relevance decision which determines further higher-level processing...... are at variance with current notions about advertising effects. For example, the att span problem will be relevant only for strategic processes, not for automatic processes, a certain amount of learning can occur with very little conscious effort, and advertising's effect on brand evaluation may be more stable...

  13. Automatic malware analysis an emulator based approach

    Yin, Heng


    Malicious software (i.e., malware) has become a severe threat to interconnected computer systems for decades and has caused billions of dollars damages each year. A large volume of new malware samples are discovered daily. Even worse, malware is rapidly evolving becoming more sophisticated and evasive to strike against current malware analysis and defense systems. Automatic Malware Analysis presents a virtualized malware analysis framework that addresses common challenges in malware analysis. In regards to this new analysis framework, a series of analysis techniques for automatic malware analy

  14. Automatic speech recognition a deep learning approach

    Yu, Dong


    This book summarizes the recent advancement in the field of automatic speech recognition with a focus on discriminative and hierarchical models. This will be the first automatic speech recognition book to include a comprehensive coverage of recent developments such as conditional random field and deep learning techniques. It presents insights and theoretical foundation of a series of recent models such as conditional random field, semi-Markov and hidden conditional random field, deep neural network, deep belief network, and deep stacking models for sequential learning. It also discusses practical considerations of using these models in both acoustic and language modeling for continuous speech recognition.

  15. Automatic and strategic processes in advertising effects

    Grunert, Klaus G.


    , and can easily be adapted to situational circumstances. Both the perception of advertising and the way advertising influences brand evaluation involves both processes. Automatic processes govern the recognition of advertising stimuli, the relevance decision which determines further higher-level processing...... are at variance with current notions about advertising effects. For example, the att span problem will be relevant only for strategic processes, not for automatic processes, a certain amount of learning can occur with very little conscious effort, and advertising's effect on brand evaluation may be more stable...

  16. Automatic cell counting with ImageJ.

    Grishagin, Ivan V


    Cell counting is an important routine procedure. However, to date there is no comprehensive, easy to use, and inexpensive solution for routine cell counting, and this procedure usually needs to be performed manually. Here, we report a complete solution for automatic cell counting in which a conventional light microscope is equipped with a web camera to obtain images of a suspension of mammalian cells in a hemocytometer assembly. Based on the ImageJ toolbox, we devised two algorithms to automatically count these cells. This approach is approximately 10 times faster and yields more reliable and consistent results compared with manual counting.

  17. TMB: Automatic differentiation and laplace approximation

    Kristensen, Kasper; Nielsen, Anders; Berg, Casper Willestofte


    computations. The user defines the joint likelihood for the data and the random effects as a C++ template function, while all the other operations are done in R; e.g., reading in the data. The package evaluates and maximizes the Laplace approximation of the marginal likelihood where the random effects...... are automatically integrated out. This approximation, and its derivatives, are obtained using automatic differentiation (up to order three) of the joint likelihood. The computations are designed to be fast for problems with many random effects (approximate to 10(6)) and parameters (approximate to 10...

  18. Eye movements in pedophiles: automatic and controlled attentional processes while viewing prepubescent stimuli.

    Fromberger, Peter; Jordan, Kirsten; Steinkrauss, Henrike; von Herder, Jakob; Stolpmann, Georg; Kröner-Herwig, Birgit; Müller, Jürgen Leo


    Recent theories in sexuality highlight the importance of automatic and controlled attentional processes in viewing sexually relevant stimuli. The model of Spiering and Everaerd (2007) assumes that sexually relevant features of a stimulus are preattentively selected and automatically induce focal attention to these sexually relevant aspects. Whether this assumption proves true for pedophiles is unknown. It is aim of this study to test this assumption empirically for people suffering from pedophilic interests. Twenty-two pedophiles, 8 nonpedophilic forensic controls, and 52 healthy controls simultaneously viewed the picture of a child and the picture of an adult while eye movements were measured. Entry time was assessed as a measure of automatic attentional processes and relative fixation time in order to assess controlled attentional processes. Pedophiles demonstrated significantly shorter entry time to child stimuli than to adult stimuli. The opposite was the case for nonpedophiles, as they showed longer relative fixation time for adult stimuli, and, against all expectations, pedophiles also demonstrated longer relative fixation time for adult stimuli. The results confirmed the hypothesis that pedophiles automatically selected sexually relevant stimuli (children). Contrary to all expectations, this automatic selection did not trigger the focal attention to these sexually relevant pictures. Furthermore, pedophiles were first and longest attracted by faces and pubic regions of children; nonpedophiles were first and longest attracted by faces and breasts of adults. The results demonstrated, for the first time, that the face and pubic region are the most attracting regions in children for pedophiles.

  19. Cognitive effort and pupil dilation in controlled and automatic processes

    Querino, Emanuel; dos Santos, Lafaiete; Ginani, Giuliano; Nicolau, Eduardo; Miranda, Débora; Romano-Silva, Marco; Malloy-Diniz, Leandro


    The Five Digits Test (FDT) is a Stroop paradigm test that aims to evaluate executive functions. It is composed of four parts, two of which are related to automatic and two of which are related to controlled processes. It is known that pupillary diameter increases as the task’s cognitive demand increases. In the present study, we evaluated whether the pupillary diameter could distinguish cognitive effort between automated and controlled cognitive processing during the FDT as the task progressed. As a control task, we used a simple reading paradigm with a similar visual aspect as the FDT. We then divided each of the four parts into two blocks in order to evaluate the differences between the first and second half of the task. Results indicated that, compared to a control task, the FDT required higher cognitive effort for each consecutive part. Moreover, the first half of every part of the FDT induced dilation more than the second. The differences in pupil dilation during the first half of the four FDT parts were statistically significant between the parts 2 and 4 (p=0.023), and between the parts 3 and 4 (p=0.006). These results provide further evidence that cognitive effort and pupil diameter can distinguish controlled from automatic processes.

  20. Cognitive effort and pupil dilation in controlled and automatic processes.

    Querino, Emanuel; Dos Santos, Lafaiete; Ginani, Giuliano; Nicolau, Eduardo; Miranda, Débora; Romano-Silva, Marco; Malloy-Diniz, Leandro


    The Five Digits Test (FDT) is a Stroop paradigm test that aims to evaluate executive functions. It is composed of four parts, two of which are related to automatic and two of which are related to controlled processes. It is known that pupillary diameter increases as the task's cognitive demand increases. In the present study, we evaluated whether the pupillary diameter could distinguish cognitive effort between automated and controlled cognitive processing during the FDT as the task progressed. As a control task, we used a simple reading paradigm with a similar visual aspect as the FDT. We then divided each of the four parts into two blocks in order to evaluate the differences between the first and second half of the task. Results indicated that, compared to a control task, the FDT required higher cognitive effort for each consecutive part. Moreover, the first half of every part of the FDT induced dilation more than the second. The differences in pupil dilation during the first half of the four FDT parts were statistically significant between the parts 2 and 4 (p=0.023), and between the parts 3 and 4 (p=0.006). These results provide further evidence that cognitive effort and pupil diameter can distinguish controlled from automatic processes.

  1. Automatic assessment of cardiac perfusion MRI

    Ólafsdóttir, Hildur; Stegmann, Mikkel Bille; Larsson, Henrik B.W.


    In this paper, a method based on Active Appearance Models (AAM) is applied for automatic registration of myocardial perfusion MRI. A semi-quantitative perfusion assessment of the registered image sequences is presented. This includes the formation of perfusion maps for three parameters; maximum up...

  2. Conscious and Automatic Processes in Language Learning.

    Carroll, John B.


    Proposes theory that the learning processes of first- and second-language learners are fundamentally the same, differing only in kinds of information used by both kinds of learners and the degree of automatization attained. Suggests designing second-language learning processes to simulate those occurring in natural settings. (Author/BK)

  3. Automatic prejudice in childhood and early adolescence

    Degner, J.; Wentura, D.


    Four cross-sectional studies are presented that investigated the automatic activation of prejudice in children and adolescents (aged 9 years to 15 years). Therefore, 4 different versions of the affective priming task were used, with pictures of ingroup and outgroup members being presented as prejudi

  4. Automatization of Student Assessment Using Multimedia Technology.

    Taniar, David; Rahayu, Wenny

    Most use of multimedia technology in teaching and learning to date has emphasized the teaching aspect only. An application of multimedia in examinations has been neglected. This paper addresses how multimedia technology can be applied to the automatization of assessment, by proposing a prototype of a multimedia question bank, which is able to…

  5. Automatization and familiarity in repeated checking

    Dek, E.C.P.|info:eu-repo/dai/nl/313959552; van den Hout, M.A.|info:eu-repo/dai/nl/070445354; Giele, C.L.|info:eu-repo/dai/nl/318754460; Engelhard, I.M.|info:eu-repo/dai/nl/239681533


    Repetitive, compulsive-like checking of an object leads to reductions in memory confidence, vividness, and detail. Experimental research suggests that this is caused by increased familiarity with perceptual characteristics of the stimulus and automatization of the checking procedure (Dek, van den Ho

  6. Automatic Water Sensor Window Opening System

    Percher, Michael


    A system can automatically open at least one window of a vehicle when the vehicle is being submerged in water. The system can include a water collector and a water sensor, and when the water sensor detects water in the water collector, at least one window of the vehicle opens.

  7. Semantic-Aware Automatic Video Editing

    S. Bocconi


    textabstractOne of the challenges of multimedia applications is to provide user-tailored access to information encoded in different media. Particularly, previous research has not yet fully explored how to automatically compose different video segments according to a communicative goal. We propose a

  8. Feedback Improvement in Automatic Program Evaluation Systems

    Skupas, Bronius


    Automatic program evaluation is a way to assess source program files. These techniques are used in learning management environments, programming exams and contest systems. However, use of automated program evaluation encounters problems: some evaluations are not clear for the students and the system messages do not show reasons for lost points.…

  9. Automatic Thesaurus Construction Using Bayesian Networks.

    Park, Young C.; Choi, Key-Sun


    Discusses automatic thesaurus construction and characterizes the statistical behavior of terms by using an inference network. Highlights include low-frequency terms and data sparseness, Bayesian networks, collocation maps and term similarity, constructing a thesaurus from a collocation map, and experiments with test collections. (Author/LRW)

  10. Automatic invariant detection in dynamic web applications

    Groeneveld, F.; Mesbah, A.; Van Deursen, A.


    The complexity of modern web applications increases as client-side JavaScript and dynamic DOM programming are used to offer a more interactive web experience. In this paper, we focus on improving the dependability of such applications by automatically inferring invariants from the client-side and us

  11. 38 CFR 51.31 - Automatic recognition.


    ...) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Obtaining Per Diem for Nursing Home Care in... that already is recognized by VA as a State home for nursing home care at the time this part becomes effective, automatically will continue to be recognized as a State home for nursing home care but will...

  12. Automatic Positioning System of Small Agricultural Robot

    Momot, M. V.; Proskokov, A. V.; Natalchenko, A. S.; Biktimirov, A. S.


    The present article discusses automatic positioning systems of agricultural robots used in field works. The existing solutions in this area have been analyzed. The article proposes an original solution, which is easy to implement and is characterized by high- accuracy positioning.

  13. ASAM: Automatic architecture synthesis and application mapping

    Jozwiak, Lech; Lindwer, Menno; Corvino, Rosilde


    This paper focuses on mastering the automatic architecture synthesis and application mapping for heterogeneous massively-parallel MPSoCs based on customizable application-specific instruction-set processors (ASIPs). It presents an overview of the research being currently performed in the scope of...

  14. What is automatized during perceptual categorization?

    Roeder, Jessica L; Ashby, F Gregory


    An experiment is described that tested whether stimulus-response associations or an abstract rule are automatized during extensive practice at perceptual categorization. Twenty-seven participants each completed 12,300 trials of perceptual categorization, either on rule-based (RB) categories that could be learned explicitly or information-integration (II) categories that required procedural learning. Each participant practiced predominantly on a primary category structure, but every third session they switched to a secondary structure that used the same stimuli and responses. Half the stimuli retained their same response on the primary and secondary categories (the congruent stimuli) and half switched responses (the incongruent stimuli). Several results stood out. First, performance on the primary categories met the standard criteria of automaticity by the end of training. Second, for the primary categories in the RB condition, accuracy and response time (RT) were identical on congruent and incongruent stimuli. In contrast, for the primary II categories, accuracy was higher and RT was lower for congruent than for incongruent stimuli. These results are consistent with the hypothesis that rules are automatized in RB tasks, whereas stimulus-response associations are automatized in II tasks. A cognitive neuroscience theory is proposed that accounts for these results.

  15. 42 CFR 407.17 - Automatic enrollment.


    ... SUPPLEMENTARY MEDICAL INSURANCE (SMI) ENROLLMENT AND ENTITLEMENT Individual Enrollment and Entitlement for SMI... enrolled for SMI if he or she: (1) Resides in the United States, except in Puerto Rico; (2) Becomes... chapter; and (3) Does not decline SMI enrollment. (b) Opportunity to decline automatic enrollment. (1)...

  16. An automatic hinge system for leg orthoses

    Rietman, J.S.; Goudsmit, J.; Meulemans, D.; Halbertsma, J.P.K.; Geertzen, J.H.B.


    This paper describes a new, automatic hinge system for leg orthoses, which provides knee stability in stance, and allows knee-flexion during swing. Indications for the hinge system are a paresis or paralysis of the quadriceps muscles. Instrumented gait analysis was performed in three patients, fitte

  17. Automatic extraction of legal concepts and definitions

    R. Winkels; R. Hoekstra


    In this paper we present the results of an experiment in automatic concept and definition extraction from written sources of law using relatively simple natural language and standard semantic web technology. The software was tested on six laws from the tax domain.

  18. Two Systems for Automatic Music Genre Recognition

    Sturm, Bob L.


    We re-implement and test two state-of-the-art systems for automatic music genre classification; but unlike past works in this area, we look closer than ever before at their behavior. First, we look at specific instances where each system consistently applies the same wrong label across multiple t...

  19. Automatically identifying periodic social events from Twitter

    Kunneman, F.A.; Bosch, A.P.J. van den


    Many events referred to on Twitter are of a periodic nature, characterized by roughly constant time intervals in between occurrences. Examples are annual music festivals, weekly television programs, and the full moon cycle. We propose a system that can automatically identify periodic events from Twi

  20. MARZ: Manual and automatic redshifting software

    Hinton, S. R.; Davis, Tamara M.; Lidman, C.; Glazebrook, K.; Lewis, G. F.


    The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application MARZ with greater usability, flexibility, and the capacity to analyse a wider range of object types than the RUNZ software package previously used for redshifting spectra from 2dF. MARZ is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the AUTOZ cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automatic matching performance for OzDES spectra has increased from 54% (RUNZ) to 91% (MARZ). Spectra not matched correctly by the automatic algorithm can be easily redshifted manually by cycling automatic results, manual template comparison, or marking spectral features.

  1. Automatically output-power-controlled WDM EDFA

    Choi, Bo-Hun; Lee, Sang Soo; Kim, Chang-Bong; Ko, Jesoo


    Our amplifier using an all optical method and a fixed GFF achieved automatic gain flatness through all C-band without any NF degradation, and simultaneously a constant 25 dB gain, while input signals were varied between one channel and forty WDM channels.

  2. Automatically extracting class diagrams from spreadsheets

    Hermans, F.; Pinzger, M.; Van Deursen, A.


    The use of spreadsheets to capture information is widespread in industry. Spreadsheets can thus be a wealthy source of domain information. We propose to automatically extract this information and transform it into class diagrams. The resulting class diagram can be used by software engineers to under

  3. Automatic Syntactic Analysis of Free Text.

    Schwarz, Christoph


    Discusses problems encountered with the syntactic analysis of free text documents in indexing. Postcoordination and precoordination of terms is discussed, an automatic indexing system call COPSY (context operator syntax) that uses natural language processing techniques is described, and future developments are explained. (60 references) (LRW)

  4. Toward the Automatic Identification of Sublanguage Vocabulary.

    Haas, Stephanie W.; He, Shaoyi


    Describes the development of a method for the automatic identification of sublanguage vocabulary words as they occur in abstracts. Highlights include research relating to sublanguages and their vocabulary; domain terms; evaluation criteria, including recall and precision; and implications for natural language processing and information retrieval.…

  5. A Statistical Approach to Automatic Speech Summarization

    Hori, Chiori; Furui, Sadaoki; Malkin, Rob; Yu, Hua; Waibel, Alex


    This paper proposes a statistical approach to automatic speech summarization. In our method, a set of words maximizing a summarization score indicating the appropriateness of summarization is extracted from automatically transcribed speech and then concatenated to create a summary. The extraction process is performed using a dynamic programming (DP) technique based on a target compression ratio. In this paper, we demonstrate how an English news broadcast transcribed by a speech recognizer is automatically summarized. We adapted our method, which was originally proposed for Japanese, to English by modifying the model for estimating word concatenation probabilities based on a dependency structure in the original speech given by a stochastic dependency context free grammar (SDCFG). We also propose a method of summarizing multiple utterances using a two-level DP technique. The automatically summarized sentences are evaluated by summarization accuracy based on a comparison with a manual summary of speech that has been correctly transcribed by human subjects. Our experimental results indicate that the method we propose can effectively extract relatively important information and remove redundant and irrelevant information from English news broadcasts.

  6. Automatic visual inspection of hybrid microcircuits

    Hines, R.E.


    An automatic visual inspection system using a minicomputer and a video digitizer was developed for inspecting hybrid microcircuits (HMC) and thin-film networks (TFN). The system performed well in detecting missing components on HMCs and reduced the testing time for each HMC by 75%.

  7. Automatic characterization of dynamics in Absence Epilepsy

    Petersen, Katrine N. H.; Nielsen, Trine N.; Kjær, Troels W.


    Dynamics of the spike-wave paroxysms in Childhood Absence Epilepsy (CAE) are automatically characterized using novel approaches. Features are extracted from scalograms formed by Continuous Wavelet Transform (CWT). Detection algorithms are designed to identify an estimate of the temporal development...

  8. Automatic Activation of Exercise and Sedentary Stereotypes

    Berry, Tanya; Spence, John C.


    We examined the automatic activation of "sedentary" and "exerciser" stereotypes using a social prime Stroop task. Results showed significantly slower response times between the exercise words and the exercise control words and between the sedentary words and the exercise control words when preceded by an attractive exerciser prime. Words preceded…

  9. Automatic Guidance System for Welding Torches

    Smith, H.; Wall, W.; Burns, M. R., Jr.


    Digital system automatically guides welding torch to produce squarebutt, V-groove and lap-joint weldments within tracking accuracy of +0.2 millimeter. Television camera observes and traverses weld joint, carrying welding torch behind. Image of joint digitized, and resulting data used to derive control signals that enable torch to track joint.

  10. A Statistical Approach to Automatic Speech Summarization

    Chiori Hori


    Full Text Available This paper proposes a statistical approach to automatic speech summarization. In our method, a set of words maximizing a summarization score indicating the appropriateness of summarization is extracted from automatically transcribed speech and then concatenated to create a summary. The extraction process is performed using a dynamic programming (DP technique based on a target compression ratio. In this paper, we demonstrate how an English news broadcast transcribed by a speech recognizer is automatically summarized. We adapted our method, which was originally proposed for Japanese, to English by modifying the model for estimating word concatenation probabilities based on a dependency structure in the original speech given by a stochastic dependency context free grammar (SDCFG. We also propose a method of summarizing multiple utterances using a two-level DP technique. The automatically summarized sentences are evaluated by summarization accuracy based on a comparison with a manual summary of speech that has been correctly transcribed by human subjects. Our experimental results indicate that the method we propose can effectively extract relatively important information and remove redundant and irrelevant information from English news broadcasts.

  11. The CHilean Automatic Supernova sEarch

    Hamuy, M.; Pignata, G.; Maza, J.


    The CHilean Automatic Supernova sEarch (CHASE) project began in 2007 with the goal to discover young, nearby southern supernovae in order to (1) better understand the physics of exploding stars and their progenitors, and (2) refine the methods to derive extragalactic distances. During the first...

  12. Automatic contour welder incorporates speed control system

    Wall, W. A., Jr.


    Speed control system maintains the welding torch of an automatic welder at a substantially constant speed. The system is particularly useful when welding contoured or unusually shaped surfaces, which cause the distance from the work surface to the weld carriage to vary in a random manner.

  13. Automatic solar lamp intensity control system

    Leverone, H.; Mandell, N.


    System that substitutes solar cells directly in the path of the radiation incident on the test volume and uses a dc bridge-null system was developed. The solar cell is affixed to a heat sink mounted on each of three arms for each solar lamp. Control of the radiation from the solar lamps is automatic.

  14. What Makes an Automatic Keyword Classification Effective?

    Jones, K. Sparck; Barber, E. O.


    The substitution information contained in automatically obtained keyword classification is most effectively exploited when: (1) strong similarity connectives only are utilized, (2) grouping is confined to non-frequent terms, (3) term groups are used to provide additional and not alternative descriptive items and (4) descriptor collection frequency…

  15. Automatic Thesaurus Generation for Chinese Documents.

    Tseng, Yuen-Hsien


    Reports an approach to automatic thesaurus construction for Chinese documents. Presents an effective Chinese keyword extraction algorithm. Compared to previous studies, this method speeds up the thesaurus generation process drastically. It also achieves a similar percentage level of term relatedness. Includes three tables and four figures.…

  16. Effective speed management through automatic enforcement.

    Oei, H.-l.


    This paper analyses several aspects of the Dutch experience of speed enforcement, and presents the results of some speed management experiments in The Netherlands, using automatic warning of speeders and enforcement of speeding. Traditional approaches to manage speed there have not resulted in satis

  17. Automatically identifying periodic social events from Twitter

    Kunneman, F.A.; Bosch, A.P.J. van den


    Many events referred to on Twitter are of a periodic nature, characterized by roughly constant time intervals in between occurrences. Examples are annual music festivals, weekly television programs, and the full moon cycle. We propose a system that can automatically identify periodic events from

  18. Automatic incrementalization of Prolog based static analyses

    Eichberg, Michael; Kahl, Matthias; Saha, Diptikalyan;


    Modem development environments integrate various static analyses into the build process. Analyses that analyze the whole project whenever the project changes are impractical in this context. We present an approach to automatic incrementalization of analyses that are specified as tabled logic prog...

  19. Automatic TLI recognition system, general description

    Lassahn, G.D.


    This report is a general description of an automatic target recognition system developed at the Idaho National Engineering Laboratory for the Department of Energy. A user`s manual is a separate volume, Automatic TLI Recognition System, User`s Guide, and a programmer`s manual is Automatic TLI Recognition System, Programmer`s Guide. This system was designed as an automatic target recognition system for fast screening of large amounts of multi-sensor image data, based on low-cost parallel processors. This system naturally incorporates image data fusion, and it gives uncertainty estimates. It is relatively low cost, compact, and transportable. The software is easily enhanced to expand the system`s capabilities, and the hardware is easily expandable to increase the system`s speed. In addition to its primary function as a trainable target recognition system, this is also a versatile, general-purpose tool for image manipulation and analysis, which can be either keyboard-driven or script-driven. This report includes descriptions of three variants of the computer hardware, a description of the mathematical basis if the training process, and a description with examples of the system capabilities.

  20. Automatic speed control of highway traffic

    Klingman, E. E.


    Vehicle control system monitors all vehicles in its range, and automatically slows down speeding vehicles by activating governor in vehicle. System determines only maximum speed; speeds below maximum are controlled by vehicle operator. Loss of transmitted signal or activation of emergency over-ride will open fuel line and return control to operator.

  1. Automatic Radiometric Normalization of Multitemporal Satellite Imagery

    Canty, Morton J.; Nielsen, Allan Aasbjerg; Schmidt, Michael


    with normalization using orthogonal regression. The procedure is applied to Landsat TM images over Nevada, Landsat ETM+ images over Morocco, and SPOT HRV images over Kenya. Results from this new automatic, combined MAD/orthogonal regression method, based on statistical analysis of test pixels not used in the actual...

  2. Automatic program generation: future of software engineering

    Robinson, J.H.


    At this moment software development is still more of an art than an engineering discipline. Each piece of software is lovingly engineered, nurtured, and presented to the world as a tribute to the writer's skill. When will this change. When will the craftsmanship be removed and the programs be turned out like so many automobiles from an assembly line. Sooner or later it will happen: economic necessities will demand it. With the advent of cheap microcomputers and ever more powerful supercomputers doubling capacity, much more software must be produced. The choices are to double the number of programers, double the efficiency of each programer, or find a way to produce the needed software automatically. Producing software automatically is the only logical choice. How will automatic programing come about. Some of the preliminary actions which need to be done and are being done are to encourage programer plagiarism of existing software through public library mechanisms, produce well understood packages such as compiler automatically, develop languages capable of producing software as output, and learn enough about the whole process of programing to be able to automate it. Clearly, the emphasis must not be on efficiency or size, since ever larger and faster hardware is coming.

  3. Greeklish: An Experimental Interface for Automatic Transliteration.

    Karakos, Alexandros


    Explains transliteration and describes Greeklish, a Windows application that automatically produces English to Greek transliteration and back-transliteration (retransliteration), based on an algorithm with a table of associations between the two character sets. Describes how the table can be modified for personal preferences and discusses its…

  4. Linking automatic evaluation to mood and information processing style: consequences for experienced affect, impression formation, and stereotyping.

    Chartrand, Tanya L; van Baaren, Rick B; Bargh, John A


    According to the feelings-as-information account, a person's mood state signals to him or her the valence of the current environment (N. Schwarz & G. Clore, 1983). However, the ways in which the environment automatically influences mood in the first place remain to be explored. The authors propose that one mechanism by which the environment influences affect is automatic evaluation, the nonconscious evaluation of environmental stimuli as good or bad. A first experiment demonstrated that repeated brief exposure to positive or negative stimuli (which leads to automatic evaluation) induces a corresponding mood in participants. In 3 additional studies, the authors showed that automatic evaluation affects information processing style. Experiment 4 showed that participants' mood mediates the effect of valenced brief primes on information processing. ((c) 2006 APA, all rights reserved).

  5. Automatic River Network Extraction from LIDAR Data

    Maderal, E. N.; Valcarcel, N.; Delgado, J.; Sevilla, C.; Ojeda, J. C.


    National Geographic Institute of Spain (IGN-ES) has launched a new production system for automatic river network extraction for the Geospatial Reference Information (GRI) within hydrography theme. The goal is to get an accurate and updated river network, automatically extracted as possible. For this, IGN-ES has full LiDAR coverage for the whole Spanish territory with a density of 0.5 points per square meter. To implement this work, it has been validated the technical feasibility, developed a methodology to automate each production phase: hydrological terrain models generation with 2 meter grid size and river network extraction combining hydrographic criteria (topographic network) and hydrological criteria (flow accumulation river network), and finally the production was launched. The key points of this work has been managing a big data environment, more than 160,000 Lidar data files, the infrastructure to store (up to 40 Tb between results and intermediate files), and process; using local virtualization and the Amazon Web Service (AWS), which allowed to obtain this automatic production within 6 months, it also has been important the software stability (TerraScan-TerraSolid, GlobalMapper-Blue Marble , FME-Safe, ArcGIS-Esri) and finally, the human resources managing. The results of this production has been an accurate automatic river network extraction for the whole country with a significant improvement for the altimetric component of the 3D linear vector. This article presents the technical feasibility, the production methodology, the automatic river network extraction production and its advantages over traditional vector extraction systems.

  6. Automatic multidiagnosis system for slit lamp

    Ventura, Liliane; Chiaradia, Caio; Vieira Messias, Andre M.; Faria de Sousa, Sidney J.; Isaac, Flavio; Caetano, Cesar A. C.; Rosa Filho, Andre B.


    We have developed a system for several automatic diagnose in Slit Lamp in order to provide 04 additional measurements to the biomicroscope: (1) counting of the endothelial cells of donated corneas; (2) automatic keratometry; (3) corneal ulcer evaluation; (4) measurement of linear distances and areas of the ocular image. The system consists in a Slit Lamp, a beam-splitter, some optical components, a CCD detector, a frame grabber and a PC. The optical components attached to the beam-splitter are the same for all the functions, except for 1. For function 1, we have developed an optical system that magnifies the image 290X and a software that counts the cells interactively and automatically. Results are in good agreement with commercial specular microscopes (correlation coefficient is 0,98081). The automatic keratometry function is able to measure cylinders over 30 di and also irregular astigmatisms. The system consists of projecting a light ring at the patient's cornea and the further analysis of the deformation of the ring provides the radius of curvature as well as the axis of the astigmatism. The nominal precision is 0,005 mm for the curvature radius and 2 degree(s) for the axis component. The results are in good agreement with commercial systems (correlation coefficient of 0,99347). For function 3, the ulcer is isolated by the usual clinical ways and the image of the green area is automatically detected by the developed software in order to evaluate the evolution of the disease. Function 4 simply allows the clinician do any linear or area measurement of the ocular image. The system is a low cost multi evaluation equipment and it is being used in a public hospital in Brazil.

  7. An automatization of Barnsley's algorithm for the inverse problem of iterated function systems.

    Wadströmer, Niclas


    We present an automatization of Barnsley's manual algorithm for the solution of the inverse problem of iterated function systems (IFSs). The problem is to retrieve the number of mappings and the parameters of an IFS from a digital binary image approximating the attractor induced by the IFS. M.F. Barnsley et al. described a way to solve manually the inverse problem by identifying the fragments of which the collage is composed, and then computing the parameters of the mappings (Barnsley et al., Proc. Nat. Acad. Sci. USA, vol.83, p.1975-7, 1986; Barnsley, "Fractals Everywhere", Academic, 1988; Barnsley and Hurd, L., "Fractal Image Compression", A.K. Peters, 1992). The automatic algorithm searches through a finite set of points in the parameter space determining a set of affine mappings. The algorithm uses the collage theorem and the Hausdorff metric. The inverse problem of IFSs is related to the image coding of binary images. If the number of mappings and the parameters of an IFS, with not too many mappings, could be obtained from a binary image, then this would give an efficient representation of the image. It is shown that the inverse problem solved by the automatic algorithm has a solution and some experiments show that the automatic algorithm is able to retrieve an IFS, including the number of mappings, from a digital binary image approximating the attractor induced by the IFS.

  8. Development of a System for Automatic Facial Expression Analysis

    Diago, Luis A.; Kitaoka, Tetsuko; Hagiwara, Ichiro

    Automatic recognition of facial expressions can be an important component of natural human-machine interactions. While a lot of samples are desirable for estimating more accurately the feelings of a person (e.g. likeness) about a machine interface, in real world situation, only a small number of samples must be obtained because the high cost in collecting emotions from observed person. This paper proposes a system that solves this problem conforming to individual differences. A new method is developed for facial expression classification based on the combination of Holographic Neural Networks (HNN) and Type-2 Fuzzy Logic. For the recognition of emotions induced by facial expressions, compared with former HNN and Support Vector Machines (SVM) classifiers, proposed method achieved the best generalization performance using less learning time than SVM classifiers.

  9. ATIPS: Automatic Travel Itinerary Planning System for Domestic Areas

    Chang, Hsien-Tsung; Chang, Yi-Ming; Tsai, Meng-Tze


    .... In this paper, we design an automatic travel itinerary planning system for the domestic area (ATIPS) using an algorithm to automatically plan a domestic travel itinerary based on user intentions that allows users to minimize the process of trip planning...

  10. PN acquisition demodulator achieves automatic synchronization of a telemetry channel

    Couvillon, L.


    Data demodulator for automatic sync acquisition provides an automatic means for obtaining initial word and bit synchronization in a pulse-code-modulated/phase-shift-keyed digital communications system.

  11. Automatic stereotyping against people with schizophrenia, schizoaffective and affective disorders

    Rüsch, N; Corrigan, P.W.; Todd, A. R.; Bodenhausen, G V


    Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-reported attitudes and emotional reactions. We therefore studied automatically activated reactions toward mental illness among 85 people with schizophrenia, schizoaffective or affec...

  12. Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.

    Schimpf, Rainer; Veltmann, Christian; Papavassiliu, Theano; Rudic, Boris; Göksu, Turgay; Kuschyk, Jürgen; Wolpert, Christian; Antzelevitch, Charles; Ebner, Alois; Borggrefe, Martin; Brandt, Christian


    The arrhythmogenic potential of short QT intervals has recently been highlighted in patients with a short QT syndrome. Drug-induced QT-interval prolongation is a known risk factor for ventricular tachyarrhythmias. However, reports on drug-induced QT-interval shortening are rare and proarrhythmic effects remain unclear. Recently, rufinamide, a new antiepileptic drug for the add-on treatment of Lennox-Gastaut syndrome, was approved in the European Union and the United States. Initial trials showed drug-induced QT-interval shortening. The aim of our study was to evaluate the effects of rufinamide on QT intervals in patients with difficult-to-treat epilepsies. Nineteen consecutive patients with Lennox-Gastaut syndrome and other epilepsy syndromes were included (n = 12 men; mean age 41 ± 12 years). QRS, QT, and T(peak)-T(end) intervals were analyzed before and during rufinamide treatment. The mean QT interval shortened significantly following rufinamide administration (QT interval 349 ± 23 ms vs 327 ± 17 ms; corrected QT interval 402 ± 22 ms vs 382 ± 16 ms; P = .002). T(peak)-T(end) intervals were 79 ± 17 ms before and 70 ± 20 ms on treatment (P = .07). The mean reduction of the corrected QT interval was 20 ± 18 ms. During follow-up (3.04 ± 1.09 years), no adverse events including symptomatic cardiac arrhythmias or sudden cardiac deaths were observed. QTc-interval shortening following oral rufinamide administration in a small patient group was not associated with significant clinical adverse effects. These observations notwithstanding, the ability of rufinamide to significantly shorten the QT interval portends a potential arrhythmogenic risk that may best be guarded against by periodic electrocardiographic recordings. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  13. Word Processing in Dyslexics: An Automatic Decoding Deficit?

    Yap, Regina; Van Der Leu, Aryan


    Compares dyslexic children with normal readers on measures of phonological decoding and automatic word processing. Finds that dyslexics have a deficit in automatic phonological decoding skills. Discusses results within the framework of the phonological deficit and the automatization deficit hypotheses. (RS)

  14. 14 CFR 29.1329 - Automatic pilot system.


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 29.1329 Section 29... pilot system. (a) Each automatic pilot system must be designed so that the automatic pilot can— (1) Be sufficiently overpowered by one pilot to allow control of the rotorcraft; and (2) Be readily and...

  15. 14 CFR 27.1329 - Automatic pilot system.


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 27.1329 Section 27... pilot system. (a) Each automatic pilot system must be designed so that the automatic pilot can— (1) Be sufficiently overpowered by one pilot to allow control of the rotorcraft; and (2) Be readily and...

  16. Automaticity of walking: functional significance, mechanisms, measurement and rehabilitation strategies

    David J Clark


    Full Text Available Automaticity is a hallmark feature of walking in adults who are healthy and well-functioning. In the context of walking, ‘automaticity’ refers to the ability of the nervous system to successfully control typical steady state walking with minimal use of attention-demanding executive control resources. Converging lines of evidence indicate that walking deficits and disorders are characterized in part by a shift in the locomotor control strategy from healthy automaticity to compensatory executive control. This is potentially detrimental to walking performance, as an executive control strategy is not optimized for locomotor control. Furthermore, it places excessive demands on a limited pool of executive reserves. The result is compromised ability to perform basic and complex walking tasks and heightened risk for adverse mobility outcomes including falls. Strategies for rehabilitation of automaticity are not well defined, which is due to both a lack of systematic research into the causes of impaired automaticity and to a lack of robust neurophysiological assessments by which to gauge automaticity. These gaps in knowledge are concerning given the serious functional implications of compromised automaticity. Therefore, the objective of this article is to advance the science of automaticity of walking by consolidating evidence and identifying gaps in knowledge regarding: a functional significance of automaticity; b neurophysiology of automaticity; c measurement of automaticity; d mechanistic factors that compromise automaticity; and e strategies for rehabilitation of automaticity.

  17. 46 CFR 153.980 - Isolation of automatic closing valves.


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Isolation of automatic closing valves. 153.980 Section... Transfer Procedures § 153.980 Isolation of automatic closing valves. The person in charge of cargo transfer may isolate automatic closing valves described in § 153.408(b) from a cargo containment system if...

  18. 29 CFR 1910.159 - Automatic sprinkler systems.


    ... 29 Labor 5 2010-07-01 2010-07-01 false Automatic sprinkler systems. 1910.159 Section 1910.159... § 1910.159 Automatic sprinkler systems. (a) Scope and application. (1) The requirements of this section apply to all automatic sprinkler systems installed to meet a particular OSHA standard. (2) For...

  19. Automatic TLI recognition system, user`s guide

    Lassahn, G.D.


    This report describes how to use an automatic target recognition system (version 14). In separate volumes are a general description of the ATR system, Automatic TLI Recognition System, General Description, and a programmer`s manual, Automatic TLI Recognition System, Programmer`s Guide.

  20. Automatic Loop Parallelization via Compiler Guided Refactoring

    Larsen, Per; Ladelsky, Razya; Lidman, Jacob

    For many parallel applications, performance relies not on instruction-level parallelism, but on loop-level parallelism. Unfortunately, many modern applications are written in ways that obstruct automatic loop parallelization. Since we cannot identify sufficient parallelization opportunities...... for these codes in a static, off-line compiler, we developed an interactive compilation feedback system that guides the programmer in iteratively modifying application source, thereby improving the compiler’s ability to generate loop-parallel code. We use this compilation system to modify two sequential...... benchmarks, finding that the code parallelized in this way runs up to 8.3 times faster on an octo-core Intel Xeon 5570 system and up to 12.5 times faster on a quad-core IBM POWER6 system. Benchmark performance varies significantly between the systems. This suggests that semi-automatic parallelization should...

  1. Image Semantic Automatic Annotation by Relevance Feedback

    ZHANG Tong-zhen; SHEN Rui-min


    A large semantic gap exists between content based index retrieval (CBIR) and high-level semantic, additional semantic information should be attached to the images, it refers in three respects including semantic representation model, semantic information building and semantic retrieval techniques. In this paper, we introduce an associated semantic network and an automatic semantic annotation system. In the system, a semantic network model is employed as the semantic representation model, it uses semantic keywords, linguistic ontology and low-level features in semantic similarity calculating. Through several times of users' relevance feedback, semantic network is enriched automatically. To speed up the growth of semantic network and get a balance annotation, semantic seeds and semantic loners are employed especially.

  2. Intelligent Storage System Based on Automatic Identification

    Kolarovszki Peter


    Full Text Available This article describes RFID technology in conjunction with warehouse management systems. Article also deals with automatic identification and data capture technologies and each processes, which are used in warehouse management system. It describes processes from entering goods into production to identification of goods and also palletizing, storing, bin transferring and removing goods from warehouse. Article focuses on utilizing AMP middleware in WMS processes in Nowadays, the identification of goods in most warehouses is carried through barcodes. In this article we want to specify, how can be processes described above identified through RFID technology. All results are verified by measurement in our AIDC laboratory, which is located at the University of Žilina, and also in Laboratory of Automatic Identification Goods and Services located in GS1 Slovakia. The results of our research bring the new point of view and indicate the ways using of RFID technology in warehouse management system.

  3. 11th Portuguese Conference on Automatic Control

    Matos, Aníbal; Veiga, Germano


    During the last 20 years the Portuguese association of automatic control, Associação Portuguesa de Controlo Automático, with the sponsorship of IFAC have established the CONTROLO conference as a reference international forum where an effective exchange of knowledge and experience amongst researchers active in various theoretical and applied areas of systems and control can take place, always including considerable space for promoting new technical applications and developments, real-world challenges and success stories. In this 11th edition the CONTROLO conference evolved by introducing two strategic partnerships with Spanish and Brazilian associations in automatic control, Comité Español de Automática and Sociedade Brasileira de Automatica, respectively.

  4. Automatic calibration method for plenoptic camera

    Luan, Yinsen; He, Xing; Xu, Bing; Yang, Ping; Tang, Guomao


    An automatic calibration method is proposed for a microlens-based plenoptic camera. First, all microlens images on the white image are searched and recognized automatically based on digital morphology. Then, the center points of microlens images are rearranged according to their relative position relationships. Consequently, the microlens images are located, i.e., the plenoptic camera is calibrated without the prior knowledge of camera parameters. Furthermore, this method is appropriate for all types of microlens-based plenoptic cameras, even the multifocus plenoptic camera, the plenoptic camera with arbitrarily arranged microlenses, or the plenoptic camera with different sizes of microlenses. Finally, we verify our method by the raw data of Lytro. The experiments show that our method has higher intelligence than the methods published before.

  5. Automatic recognition of malicious intent indicators.

    Drescher, D. J.; Yee, Mark L.; Giron, Casey; Fogler, Robert Joseph; Nguyen, Hung D.; Koch, Mark William


    A major goal of next-generation physical protection systems is to extend defenses far beyond the usual outer-perimeter-fence boundaries surrounding protected facilities. Mitigation of nuisance alarms is among the highest priorities. A solution to this problem is to create a robust capability to Automatically Recognize Malicious Indicators of intruders. In extended defense applications, it is not enough to distinguish humans from all other potential alarm sources as human activity can be a common occurrence outside perimeter boundaries. Our approach is unique in that it employs a stimulus to determine a malicious intent indicator for the intruder. The intruder's response to the stimulus can be used in an automatic reasoning system to decide the intruder's intent.

  6. Automaticity and hypnosis: a sociocognitive account.

    Lynn, S J


    This article provides an overview of a new theory of suggested involuntariness in hypnosis, developed in conjunction with Irving Kirsch. The theory is based on the following ideas. First, high hypnotizable participants enter hypnosis with a conscious intention to feel and behave in line with suggested experiences and movements. Second, people who are easily hypnotized hold firm expectations that they will succeed in following the suggestions of the hypnotist. Third, the intention and expectation in turn function as response sets in the sense that they trigger the hypnotic response automatically. Fourth, given the intention to feel and behave in line with the hypnotist's suggestions, hypnotized individuals show no hesitation to experience the suggested movements as involuntary because (a) these movements are actually triggered automatically, and (b) the intention to cooperate with the hypnotist as well as the expectation to be able to do so create a heightened readiness to experience these actions as involuntary.

  7. An Approximate Approach to Automatic Kernel Selection.

    Ding, Lizhong; Liao, Shizhong


    Kernel selection is a fundamental problem of kernel-based learning algorithms. In this paper, we propose an approximate approach to automatic kernel selection for regression from the perspective of kernel matrix approximation. We first introduce multilevel circulant matrices into automatic kernel selection, and develop two approximate kernel selection algorithms by exploiting the computational virtues of multilevel circulant matrices. The complexity of the proposed algorithms is quasi-linear in the number of data points. Then, we prove an approximation error bound to measure the effect of the approximation in kernel matrices by multilevel circulant matrices on the hypothesis and further show that the approximate hypothesis produced with multilevel circulant matrices converges to the accurate hypothesis produced with kernel matrices. Experimental evaluations on benchmark datasets demonstrate the effectiveness of approximate kernel selection.

  8. Research and implementation of software automatic test

    Li-hong, LIAN


    With the fast development in IT technology nowadays, software is increasingly complex and large. Hundreds of people in the development team, thousands of modules and interfaces, across geographies and systems user are no longer a fresh thing. All of these put forward higher requirements for software testing. Due to the low cost of implementation and the advantage of effective inheritance and accumulation of test assets, software automation testing has gradually become one of the important means to ensure the quality of software for IT enterprises. This paper analyzes the advantages of automatic test, common misconceptions; puts forward unsuitable application scenarios and the best time to intervene; focus on the analysis of the feasibility of judging the interface automation test; and puts forward the function and elements of interface automatic test tools to have; provides a reference for large-scale project interface automated testing tool selection or custom development.

  9. Automatic document navigation for digital content remastering

    Lin, Xiaofan; Simske, Steven J.


    This paper presents a novel method of automatically adding navigation capabilities to re-mastered electronic books. We first analyze the need for a generic and robust system to automatically construct navigation links into re-mastered books. We then introduce the core algorithm based on text matching for building the links. The proposed method utilizes the tree-structured dictionary and directional graph of the table of contents to efficiently conduct the text matching. Information fusion further increases the robustness of the algorithm. The experimental results on the MIT Press digital library project are discussed and the key functional features of the system are illustrated. We have also investigated how the quality of the OCR engine affects the linking algorithm. In addition, the analogy between this work and Web link mining has been pointed out.

  10. Meteorological Automatic Weather Station (MAWS) Instrument Handbook

    Holdridge, Donna J [Argonne National Lab. (ANL), Argonne, IL (United States); Kyrouac, Jenni A [Argonne National Lab. (ANL), Argonne, IL (United States)


    The Meteorological Automatic Weather Station (MAWS) is a surface meteorological station, manufactured by Vaisala, Inc., dedicated to the balloon-borne sounding system (BBSS), providing surface measurements of the thermodynamic state of the atmosphere and the wind speed and direction for each radiosonde profile. These data are automatically provided to the BBSS during the launch procedure and included in the radiosonde profile as the surface measurements of record for the sounding. The MAWS core set of measurements is: Barometric Pressure (hPa), Temperature (°C), Relative Humidity (%), Arithmetic-Averaged Wind Speed (m/s), and Vector-Averaged Wind Direction (deg). The sensors that collect the core variables are mounted at the standard heights defined for each variable: • Temperature and relative humidity: 2 meters • Barometric pressure: 1 meter • Winds: 10 meters.

  11. On automatic visual inspection of reflective surfaces

    Kulmann, Lionel


    surveyed visual inspection system design methods and presented available image processing hardware to perform high resolution image capture. We present general usable practical visual inspection system solutions, when performing high resolution visual inspection of surfaces. We have presented known and new......This thesis descrbes different methods to perform automatic visual inspection of reflective manufactured products, with the aim of increasing productivity, reduce cost and improve the quality level of the production. We investigate two different systems performing automatic visual inspection...... in algorithms for detecting 3-dimensional surface damages based on images from a novel structured lighting setup enhancing the appearance of these defects in specular surfaces. A hardware implementable polynomial classifier structure has been described and compared to better known techniques based...

  12. Testing Forms in Web Applications Automatically

    XU Lei; XU Baowen


    Forms enhance both the dynamic and interactive abilities of Web applications and the system complexity. And it is especially important to test forms completely and thoroughly. Therefore, this paper discusses how to carry out the form testing by different methods in the related testing phases. Namely, at first, automatically abstracting forms in the Web pages by parsing the HTML documents; then, obtaining the testing data with a certain strategies, such as by requirement specifications, by mining users' before input information or by recording mechanism; and next executing the testing actions automatically due to the well-formed test cases; finally, a case study is given to illustrate the convenient and effective of these methods.

  13. Automatic traveltime picking using instantaneous traveltime

    Saragiotis, Christos


    Event picking is used in many steps of seismic processing. We present an automatic event picking method that is based on a new attribute of seismic signals, instantaneous traveltime. The calculation of the instantaneous traveltime consists of two separate but interrelated stages. First, a trace is mapped onto the time-frequency domain. Then the time-frequency representation is mapped back onto the time domain by an appropriate operation. The computed instantaneous traveltime equals the recording time at those instances at which there is a seismic event, a feature that is used to pick the events. We analyzed the concept of the instantaneous traveltime and demonstrated the application of our automatic picking method on dynamite and Vibroseis field data.

  14. Automatic stereoscopic system for person recognition

    Murynin, Alexander B.; Matveev, Ivan A.; Kuznetsov, Victor D.


    A biometric access control system based on identification of human face is presented. The system developed performs remote measurements of the necessary face features. Two different scenarios of the system behavior are implemented. The first one assumes the verification of personal data entered by visitor from console using keyboard or card reader. The system functions as an automatic checkpoint, that strictly controls access of different visitors. The other scenario makes it possible to identify visitors without any person identifier or pass. Only person biometrics are used to identify the visitor. The recognition system automatically finds necessary identification information preliminary stored in the database. Two laboratory models of recognition system were developed. The models are designed to use different information types and sources. In addition to stereoscopic images inputted to computer from cameras the models can use voice data and some person physical characteristics such as person's height, measured by imaging system.

  15. Towards automatic classification of all WISE sources

    Kurcz, Agnieszka; Solarz, Aleksandra; Krupa, Magdalena; Pollo, Agnieszka; Małek, Katarzyna


    The WISE satellite has detected hundreds of millions sources over the entire sky. Classifying them reliably is however a challenging task due to degeneracies in WISE multicolour space and low levels of detection in its two longest-wavelength bandpasses. Here we aim at obtaining comprehensive and reliable star, galaxy and quasar catalogues based on automatic source classification in full-sky WISE data. This means that the final classification will employ only parameters available from WISE itself, in particular those reliably measured for a majority of sources. For the automatic classification we applied the support vector machines (SVM) algorithm, which requires a training sample with relevant classes already identified, and we chose to use the SDSS spectroscopic dataset for that purpose. By calibrating the classifier on the test data drawn from SDSS, we first established that a polynomial kernel is preferred over a radial one for this particular dataset. Next, using three classification parameters (W1 magnit...

  16. Automatic Classification of Attacks on IP Telephony

    Jakub Safarik


    Full Text Available This article proposes an algorithm for automatic analysis of attack data in IP telephony network with a neural network. Data for the analysis is gathered from variable monitoring application running in the network. These monitoring systems are a typical part of nowadays network. Information from them is usually used after attack. It is possible to use an automatic classification of IP telephony attacks for nearly real-time classification and counter attack or mitigation of potential attacks. The classification use proposed neural network, and the article covers design of a neural network and its practical implementation. It contains also methods for neural network learning and data gathering functions from honeypot application.

  17. Development of an automatic pipeline scanning system

    Kim, Jae H.; Lee, Jae C.; Moon, Soon S.; Eom, Heung S.; Choi, Yu R


    Pressure pipe inspection in nuclear power plants is one of the mandatory regulation items. Comparing to manual ultrasonic inspection, automatic inspection has the benefits of more accurate and reliable inspection results and reduction of radiation disposal. final object of this project is to develop an automatic pipeline inspection system of pressure pipe welds in nuclear power plants. We developed a pipeline scanning robot with four magnetic wheels and 2-axis manipulator for controlling ultrasonic transducers, and developed the robot control computer which controls the robot to navigate along inspection path exactly. We expect our system can contribute to reduction of inspection time, performance enhancement, and effective management of inspection results. The system developed by this project can be practically used for inspection works after field tests. (author)

  18. Fully Automatic Expression-Invariant Face Correspondence

    Salazar, Augusto; Shu, Chang; Prieto, Flavio


    We consider the problem of computing accurate point-to-point correspondences among a set of human face scans with varying expressions. Our fully automatic approach does not require any manually placed markers on the scan. Instead, the approach learns the locations of a set of landmarks present in a database and uses this knowledge to automatically predict the locations of these landmarks on a newly available scan. The predicted landmarks are then used to compute point-to-point correspondences between a template model and the newly available scan. To accurately fit the expression of the template to the expression of the scan, we use as template a blendshape model. Our algorithm was tested on a database of human faces of different ethnic groups with strongly varying expressions. Experimental results show that the obtained point-to-point correspondence is both highly accurate and consistent for most of the tested 3D face models.

  19. Automatic-Control System for Safer Brazing

    Stein, J. A.; Vanasse, M. A.


    Automatic-control system for radio-frequency (RF) induction brazing of metal tubing reduces probability of operator errors, increases safety, and ensures high-quality brazed joints. Unit combines functions of gas control and electric-power control. Minimizes unnecessary flow of argon gas into work area and prevents electrical shocks from RF terminals. Controller will not allow power to flow from RF generator to brazing head unless work has been firmly attached to head and has actuated micro-switch. Potential shock hazard eliminated. Flow of argon for purging and cooling must be turned on and adjusted before brazing power applied. Provision ensures power not applied prematurely, causing damaged work or poor-quality joints. Controller automatically turns off argon flow at conclusion of brazing so potentially suffocating gas does not accumulate in confined areas.

  20. Towards Automatic Decentralized Control Structure Selection

    for decentralized control is determined automatically, and the resulting decentralized control structure is automatically tuned using standard techniques. Dynamic simulation of the resulting process system gives immediate feedback to the process design engineer regarding practical operability of the process......A subtask in integration of design and control of chemical processes is the selection of a control structure. Automating the selection of the control structure enables sequential integration of process and controld esign. As soon as the process is specified or computed, a structure....... The control structure selection problem is formulated as a special MILP employing cost coefficients which are computed using Parseval's theorem combined with RGA and IMC concepts. This approach enables selection and tuning of large-scale plant-wide decentralized controllers through efficient combination...

  1. Automatic-Control System for Safer Brazing

    Stein, J. A.; Vanasse, M. A.


    Automatic-control system for radio-frequency (RF) induction brazing of metal tubing reduces probability of operator errors, increases safety, and ensures high-quality brazed joints. Unit combines functions of gas control and electric-power control. Minimizes unnecessary flow of argon gas into work area and prevents electrical shocks from RF terminals. Controller will not allow power to flow from RF generator to brazing head unless work has been firmly attached to head and has actuated micro-switch. Potential shock hazard eliminated. Flow of argon for purging and cooling must be turned on and adjusted before brazing power applied. Provision ensures power not applied prematurely, causing damaged work or poor-quality joints. Controller automatically turns off argon flow at conclusion of brazing so potentially suffocating gas does not accumulate in confined areas.

  2. Automatic differentiation using vectorized hyper dual numbers

    Swaroop, Kshitiz

    Sensitivity analysis is a method to measure the change in a dependent variable with respect to one or more independent variables with uses including optimization, design analysis and risk modeling. Conventional methods like finite difference suffer from both truncation, subtraction errors and cannot be used to simultaneously calculate derivatives of an output with respect to multiple inputs (commonly seen in optimization problems). Automatic Differentiation tackles all these issues successfully allowing us to calculate derivatives of any variable with respect to the independent variables in a computer program up to machine precision without any significant user input. Vectorized Hyper Dual Numbers, an extension of Hyper Dual Numbers, which allows the user to automatically calculate both the Hessian and derivative along with the function evaluation is developed for this thesis. The method is then used for the sizing and layup of a composite wind turbine blade as a proof of concept.

  3. Automatic modulation recognition of communication signals

    Azzouz, Elsayed Elsayed


    Automatic modulation recognition is a rapidly evolving area of signal analysis. In recent years, interest from the academic and military research institutes has focused around the research and development of modulation recognition algorithms. Any communication intelligence (COMINT) system comprises three main blocks: receiver front-end, modulation recogniser and output stage. Considerable work has been done in the area of receiver front-ends. The work at the output stage is concerned with information extraction, recording and exploitation and begins with signal demodulation, that requires accurate knowledge about the signal modulation type. There are, however, two main reasons for knowing the current modulation type of a signal; to preserve the signal information content and to decide upon the suitable counter action, such as jamming. Automatic Modulation Recognition of Communications Signals describes in depth this modulation recognition process. Drawing on several years of research, the authors provide a cr...

  4. Automatic Palette Identification of Colored Graphics

    Lacroix, Vinciane

    The median-shift, a new clustering algorithm, is proposed to automatically identify the palette of colored graphics, a pre-requisite for graphics vectorization. The median-shift is an iterative process which shifts each data point to the "median" point of its neighborhood defined thanks to a distance measure and a maximum radius, the only parameter of the method. The process is viewed as a graph transformation which converges to a set of clusters made of one or several connected vertices. As the palette identification depends on color perception, the clustering is performed in the L*a*b* feature space. As pixels located on edges are made of mixed colors not expected to be part of the palette, they are removed from the initial data set by an automatic pre-processing. Results are shown on scanned maps and on the Macbeth color chart and compared to well established methods.

  5. Towards Automatic Decentralized Control Structure Selection

    Jørgensen, John Bagterp; Jørgensen, Sten Bay


    A subtask in integration of design and control of chemical processes is the selection of a control structure. Automating the selection of the control structure enables sequential integration of process and control design. As soon as the process is specified or computed, a structure...... for decentralized control is determined automatically, and the resulting decentralized control structure is automatically tuned using standard techniques. Dynamic simulation of the resulting process system gives immediate feedback to the process design engineer regarding practical operability of the process....... The control structure selection problem is formulated as a special MILP employing cost coefficients which are computed using Parseval's theorem combined with RGA and IMC concepts. This approach enables selection and tuning of large-scale plant-wide decentralized controllers through efficient combination...

  6. Automatic Phonetic Transcription for Danish Speech Recognition

    Kirkedal, Andreas Søeborg

    Automatic speech recognition (ASR) uses dictionaries that map orthographic words to their phonetic representation. To minimize the occurrence of out-of-vocabulary words, ASR requires large phonetic dictionaries to model pronunciation. Hand-crafted high-quality phonetic dictionaries are difficult......, like Danish, the graphemic and phonetic representations are very dissimilar and more complex rewriting rules must be applied to create the correct phonetic representation. Automatic phonetic transcribers use different strategies, from deep analysis to shallow rewriting rules, to produce phonetic......, syllabication, stød and several other suprasegmental features (Kirkedal, 2013). Simplifying the transcriptions by filtering out the symbols for suprasegmental features in a post-processing step produces a format that is suitable for ASR purposes. eSpeak is an open source speech synthesizer originally created...

  7. Multilabel Learning for Automatic Web Services Tagging

    Mustapha AZNAG; Mohamed QUAFAFOU; Jarir, Zahi


    Recently, some web services portals and search engines as Biocatalogue and Seekda!, have allowed users to manually annotate Web services using tags. User Tags provide meaningful descriptions of services and allow users to index and organize their contents. Tagging technique is widely used to annotate objects in Web 2.0 applications. In this paper we propose a novel probabilistic topic model (which extends the CorrLDA model - Correspondence Latent Dirichlet Allocation-) to automatically tag we...

  8. Automatic approach for generating ETL operators

    Bakari, Wided; Ali, Mouez; Ben-Abdallah, Hanene


    This article addresses the generation of the ETL operators(Extract-Transform-Load) for supplying a Data Warehouse from a relational data source. As a first step, we add new rules to those proposed by the authors of [1], these rules deal with the combination of ETL operators. In a second step, we propose an automatic approach based on model transformations to generate the ETL operations needed for loading a data warehouse. This approach offers the possibility to set some designer requirements ...

  9. Automatic landslides detection on Stromboli volcanic Island

    Silengo, Maria Cristina; Delle Donne, Dario; Ulivieri, Giacomo; Cigolini, Corrado; Ripepe, Maurizio


    Landslides occurring in active volcanic islands play a key role in triggering tsunami and other related risks. Therefore, it becomes vital for a correct and prompt risk assessment to monitor landslides activity and to have an automatic system for a robust early-warning. We then developed a system based on a multi-frequency analysis of seismic signals for automatic landslides detection occurring at Stromboli volcano. We used a network of 4 seismic 3 components stations located along the unstable flank of the Sciara del Fuoco. Our method is able to recognize and separate the different sources of seismic signals related to volcanic and tectonic activity (e.g. tremor, explosions, earthquake) from landslides. This is done using a multi-frequency analysis combined with a waveform patter recognition. We applied the method to one year of seismic activity of Stromboli volcano centered during the last 2007 effusive eruption. This eruption was characterized by a pre-eruptive landslide activity reflecting the slow deformation of the volcano edifice. The algorithm is at the moment running off-line but has proved to be robust and efficient in picking automatically landslide. The method provides also real-time statistics on the landslide occurrence, which could be used as a proxy for the volcano deformation during the pre-eruptive phases. This method is very promising since the number of false detections is quite small (landslide increases. The final aim will be to apply this method on-line and for a real-time automatic detection as an improving tool for early warnings of tsunami-genic landslide activity. We suggest that a similar approach could be also applied to other unstable non-volcanic also slopes.

  10. Automatic generation of multilingual sports summaries

    Hasan, Fahim Muhammad


    Natural Language Generation is a subfield of Natural Language Processing, which is concerned with automatically creating human readable text from non-linguistic forms of information. A template-based approach to Natural Language Generation utilizes base formats for different types of sentences, which are subsequently transformed to create the final readable forms of the output. In this thesis, we investigate the suitability of a template-based approach to multilingual Natural Language Generat...

  11. Automatic Algorithm Selection for Complex Simulation Problems

    Ewald, Roland


    To select the most suitable simulation algorithm for a given task is often difficult. This is due to intricate interactions between model features, implementation details, and runtime environment, which may strongly affect the overall performance. An automated selection of simulation algorithms supports users in setting up simulation experiments without demanding expert knowledge on simulation. Roland Ewald analyzes and discusses existing approaches to solve the algorithm selection problem in the context of simulation. He introduces a framework for automatic simulation algorithm selection and

  12. Automatic location of short circuit faults

    Lehtonen, M. [VTT Energy, Espoo (Finland); Hakola, T.; Antila, E. [ABB Power Oy, Helsinki (Finland); Seppaenen, M. [North-Carelian Power Company (Finland)


    In this presentation, the automatic location of short circuit faults on medium voltage distribution lines, based on the integration of computer systems of medium voltage distribution network automation is discussed. First the distribution data management systems and their interface with the substation telecontrol, or SCADA systems, is studied. Then the integration of substation telecontrol system and computerised relay protection is discussed. Finally, the implementation of the fault location system is presented and the practical experience with the system is discussed

  13. An Incremental Approach to Automatic Algorithm Design

    LUAN Shangmin; LI Wei


    This paper presents an incrementalapproach to automatic algorithm design, which can be described byalgebraic specifications precisely and conveniently. The definitions ofselection operator and extension operator which can be defined bystrategy relations and transformations are given in order to model theprocess of finding the solution of a problem. Also discussed is itsobject-oriented implementation. The functional specification and thedesign specification for an algorithm are given in one framework so thatthe correctness of the algorithm can be easily proved.

  14. Fast Automatic Heuristic Construction Using Active Learning

    Ogilvie, William; Petoumenos, Pavlos; Wang, Zheng; Leather, Hugh


    Building effective optimization heuristics is a challenging task which often takes developers several months if not years to complete. Predictive modelling has recently emerged as a promising solution, automatically constructing heuristics from training data. However, obtaining this data can take months per platform. This is becoming an ever more critical problem and if no solution is found we shall be left with out of date heuristics which cannot extract the best performance from modern mach...

  15. Automatic learning by an autonomous mobile robot

    de Saussure, G.; Spelt, P.F.; Killough, S.M.; Pin, F.G.; Weisbin, C.R.


    This paper describes recent research in automatic learning by the autonomous mobile robot HERMIES-IIB at the Center for Engineering Systems Advanced Research (CESAR). By acting on the environment and observing the consequences during a set of training examples, the robot learns a sequence of successful manipulations on a simulated control panel. The robot learns to classify panel configurations in order to deal with new configurations that are not part of the original training set. 5 refs., 2 figs.

  16. Automatic Extraction of JPF Options and Documentation

    Luks, Wojciech; Tkachuk, Oksana; Buschnell, David


    Documenting existing Java PathFinder (JPF) projects or developing new extensions is a challenging task. JPF provides a platform for creating new extensions and relies on key-value properties for their configuration. Keeping track of all possible options and extension mechanisms in JPF can be difficult. This paper presents jpf-autodoc-options, a tool that automatically extracts JPF projects options and other documentation-related information, which can greatly help both JPF users and developers of JPF extensions.

  17. Automatic basal slice detection for cardiac analysis

    Paknezhad, Mahsa; Marchesseau, Stephanie; Brown, Michael S.


    Identification of the basal slice in cardiac imaging is a key step to measuring the ejection fraction (EF) of the left ventricle (LV). Despite research on cardiac segmentation, basal slice identification is routinely performed manually. Manual identification, however, has been shown to have high inter-observer variability, with a variation of the EF by up to 8%. Therefore, an automatic way of identifying the basal slice is still required. Prior published methods operate by automatically tracking the mitral valve points from the long-axis view of the LV. These approaches assumed that the basal slice is the first short-axis slice below the mitral valve. However, guidelines published in 2013 by the society for cardiovascular magnetic resonance indicate that the basal slice is the uppermost short-axis slice with more than 50% myocardium surrounding the blood cavity. Consequently, these existing methods are at times identifying the incorrect short-axis slice. Correct identification of the basal slice under these guidelines is challenging due to the poor image quality and blood movement during image acquisition. This paper proposes an automatic tool that focuses on the two-chamber slice to find the basal slice. To this end, an active shape model is trained to automatically segment the two-chamber view for 51 samples using the leave-one-out strategy. The basal slice was detected using temporal binary profiles created for each short-axis slice from the segmented two-chamber slice. From the 51 successfully tested samples, 92% and 84% of detection results were accurate at the end-systolic and the end-diastolic phases of the cardiac cycle, respectively.

  18. Automatic location of short circuit faults

    Lehtonen, M. [VTT Energy, Espoo (Finland); Hakola, T.; Antila, E. [ABB Power Oy (Finland); Seppaenen, M. [North-Carelian Power Company (Finland)


    In this chapter, the automatic location of short circuit faults on medium voltage distribution lines, based on the integration of computer systems of medium voltage distribution network automation is discussed. First the distribution data management systems and their interface with the substation telecontrol, or SCADA systems, is studied. Then the integration of substation telecontrol system and computerized relay protection is discussed. Finally, the implementation of the fault location system is presented and the practical experience with the system is discussed

  19. Multilingual Vocabularies in Automatic Speech Recognition


    monolingual (a few thousands) is an obstacle to a full generalization of the inventories, then moved to the multilingual case. In the approach towards the...language. of multilingual models than the monolingual models, and it was specifically observed in the test with Spanish utterances. In fact...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP010389 TITLE: Multilingual Vocabularies in Automatic Speech Recognition

  20. Automatic generation of tree level helicity amplitudes

    Stelzer, T


    The program MadGraph is presented which automatically generates postscript Feynman diagrams and Fortran code to calculate arbitrary tree level helicity amplitudes by calling HELAS[1] subroutines. The program is written in Fortran and is available in Unix and VMS versions. MadGraph currently includes standard model interactions of QCD and QFD, but is easily modified to include additional models such as supersymmetry.

  1. Automatic modulation classification principles, algorithms and applications

    Zhu, Zhechen


    Automatic Modulation Classification (AMC) has been a key technology in many military, security, and civilian telecommunication applications for decades. In military and security applications, modulation often serves as another level of encryption; in modern civilian applications, multiple modulation types can be employed by a signal transmitter to control the data rate and link reliability. This book offers comprehensive documentation of AMC models, algorithms and implementations for successful modulation recognition. It provides an invaluable theoretical and numerical comparison of AMC algo

  2. PLC Based Automatic Multistoried Car Parking System


    This project work presents the study and design of PLC based Automatic Multistoried Car Parking System. Multistoried car parking is an arrangement which is used to park a large number of vehicles in least possible place. For making this arrangement in a real plan very high technological instruments are required. In this project a prototype of such a model is made. This prototype model is made for accommodating twelve cars at a time. Availability of the space for parking is detecte...

  3. Automatic Control of Personal Rapid Transit Vehicles

    Smith, P. D.


    The requirements for automatic longitudinal control of a string of closely packed personal vehicles are outlined. Optimal control theory is used to design feedback controllers for strings of vehicles. An important modification of the usual optimal control scheme is the inclusion of jerk in the cost functional. While the inclusion of the jerk term was considered, the effect of its inclusion was not sufficiently studied. Adding the jerk term will increase passenger comfort.

  4. Using Protege for Automatic Ontology Instantiation


    This paper gives an overview on the use of Protégé in the Artequakt system, which integrated Protégé with a set of natural language tools to automatically extract knowledge about artists from web documents and instantiate a given ontology. Protégé was also linked to structured templates that generate documents from the knowledge fragments it maintains.

  5. Automatic surface inoculation of agar trays.

    Wilkins, J. R.; Mills, S. M.; Boykin, E. H.


    Description of a machine and technique for the automatic inoculation of a plastic tray containing agar media with a culture, using either a conventional inoculation loop or a cotton swab. The design of the machine is simple, it is easy to use, and it relieves the operator from the manual task of streaking cultures. The described technique makes possible the visualization of the overall qualitative and, to some extent, quantitative relationships of various bacterial types in a sample tested.

  6. Finding Difficult Speakers in Automatic Speaker Recognition

    Stoll, Lara Lynn


    The task of automatic speaker recognition, wherein a system verifies or determines a speaker's identity using a sample of speech, has been studied for a few decades. In that time, a great deal of progress has been made in improving the accuracy of the system's decisions, through the use of more successful machine learning algorithms, and the application of channel compensation techniques and other methodologies aimed at addressing sources of errors such as noise or data mismatch. In general, ...

  7. Automatic systems win; Siegeszug der Automaten

    Sorg, M


    This short article presents figures on the increasing use of modern, automatic wood-fired heating systems in Switzerland that are not only replacing older installations but also starting to replace other forms of heating. The increase of the number of wood-based heating systems installed and the amount of wood used in them is discussed, as are developments in the market for large-scale wood-based heating systems.

  8. Automatic system for ionization chamber current measurements.

    Brancaccio, Franco; Dias, Mauro S; Koskinas, Marina F


    The present work describes an automatic system developed for current integration measurements at the Laboratório de Metrologia Nuclear of Instituto de Pesquisas Energéticas e Nucleares. This system includes software (graphic user interface and control) and a module connected to a microcomputer, by means of a commercial data acquisition card. Measurements were performed in order to check the performance and for validating the proposed design.

  9. Automatic Information Processing and High Performance Skills


    Society Twenty-Sixth Annual Meeting (pp. 10-14). Santa Monica, CA: Human Factors Society. Shiffrin , R. M. (1988). Attention. In R. C. Atkinson , R. J...Learning. Memory . and Cognition, 1A, 562-569. Shiffrin , R. M., and Dumais, S. T. (1981). The development of automatism. In J. R. Anderson (Ed.), Cognitive...Change and Skill Acquisition in Visual Search ................................... 43 iii TABLE OF CONTENTS (Continued) Consistent Memory and Visual Search

  10. Automatic Multimodal Cognitive Load Measurement (AMCLM)


    Final Project Report Grant AOARD-10-4029 Automatic Multimodal Cognitive Load Measurement (AMCLM) June 2011 NICTA DSIM Team...collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 12 AUG 2011 2. REPORT TYPE 3. DATES COVERED 4...human-computer interface, such as air traffic control , in-car safety and electronic games. By quantifying the mental efforts of a person when

  11. Automatic Detection of Cyberbullying on Social Media

    Engman, Love


    Bullying on social media is a dire problem for many youths, leading to severe health problems. In this thesis we describe the construction of a software prototype capable of automatically identifying bullying comments on the social media platform ASKfm using Natural Language Processing (NLP) and Machine Learning (ML) techniques. State of the art NLP and ML algorithms from previous research are studied and evaluated for the task of identifying bullying comments in a data set from ASKfm. The be...

  12. Automatization and training in visual search.

    Czerwinski, M; Lightfoot, N; Shiffrin, R M


    In several search tasks, the amount of practice on particular combinations of targets and distractors was equated in varied-mapping (VM) and consistent-mapping (CM) conditions. The results indicate the importance of distinguishing between memory and visual search tasks, and implicate a number of factors that play important roles in visual search and its learning. Visual search was studied in Experiment 1. VM and CM performance were almost equal, and slope reductions occurred during practice for both, suggesting the learning of efficient attentive search based on features, and no important role for automatic attention attraction. However, positive transfer effects occurred when previous CM targets were re-paired with previous CM distractors, even though these targets and distractors had not been trained together. Also, the introduction of a demanding simultaneous task produced advantages of CM over VM. These latter two results demonstrated the operation of automatic attention attraction. Visual search was further studied in Experiment 2, using novel characters for which feature overlap and similarity were controlled. The design and many of the findings paralleled Experiment 1. In addition, enormous search improvement was seen over 35 sessions of training, suggesting the operation of perceptual unitization for the novel characters. Experiment 3 showed a large, persistent advantage for CM over VM performance in memory search, even when practice on particular combinations of targets and distractors was equated in the two training conditions. A multifactor theory of automatization and attention is put forth to account for these findings and others in the literature.

  13. Evaluation of automatic vacuum- assisted compaction solutions

    M. Brzeziński


    Full Text Available Currently on the mould-making machines market the companies like: DiSA, KUENKEL WAGNER, HAFLINGER, HEINRICH WAGNER SINTO, HUNTER, SAVELLI AND TECHNICAL play significant role. These companies are the manufacturers of various solutions in machines and instalations applied in foundry engineering. Automatic foundry machines for compaction of green sand have the major role in mechanisation and automation processes of making the mould. The concept of operation of automatic machines is based on the static and dynamic methods of compacting the green sand. The method which gains the importance is the compacting method by using the energy of the air pressure. It's the initial stage or the supporting process of compacting the green sand. However in the automatic mould making machines using this method it's essential to use the additional compaction of the mass in order to receive the final parameters of the form. In the constructional solutions of the machines there is the additional division which concerns the method of putting the sand into the mould box. This division distinquishes the transport of the sand with simultaneous compaction or the putting of the sand without the pre-compaction. As the solutions of the major manufacturers are often the subject for application in various foundries, the authors of the paper would like/have the confidence to present their own evaluation process confirmed by their own researches and independent analysis of the producers' solutions.

  14. Automatic gray scale correction of video data

    Chochia, Pavel A.


    Automatic gray scale correction of captured video data (both still and moving images) is one of the least researched questions in the image processing area, in spite of this the question is touched almost in every book concerned with image processing. Classically it is related to the image enhancement, and frequently is classified as histogram modification techniques. Traditionally used algorithms, based on analysis of the image histogram, are not able to decide the problem properly. The investigating difficulties are associated with the absence of a formal quantitative estimate of image quality -- till now the most often used criteria are human visual perception and experience. Hence, the problem of finding out some measurable properties of real images, which might be the basis for automatic building of gray scale correction function (sometimes identified also as gamma-correction function), is still unsolved. In the paper we try to discern some common properties of real images that could help us to evaluate the gray scale image distortion, and, finally, to construct the appropriate correction function to enhance an image. Such a method might be sufficiently used for automatic image processing procedures, like enhancing of medical images, reproducing of pictures in the publishing industry, correcting of remote sensing images, preprocessing of captured data in the computer vision area, and for many other applications. The question of complexity of analysis procedure becomes important when an algorithm is realized in real-time (for example in video input devices, like video cameras).

  15. Automatic morphometry of nerve histological sections.

    Romero, E; Cuisenaire, O; Denef, J F; Delbeke, J; Macq, B; Veraart, C


    A method for the automatic segmentation, recognition and measurement of neuronal myelinated fibers in nerve histological sections is presented. In this method, the fiber parameters i.e. perimeter, area, position of the fiber and myelin sheath thickness are automatically computed. Obliquity of the sections may be taken into account. First, the image is thresholded to provide a coarse classification between myelin and non-myelin pixels. Next, the resulting binary image is further simplified using connected morphological operators. By applying semantic rules to the zonal graph axon candidates are identified. Those are either isolated or still connected. Then, separation of connected fibers is performed by evaluating myelin sheath thickness around each candidate area with an Euclidean distance transformation. Finally, properties of each detected fiber are computed and false positives are removed. The accuracy of the method is assessed by evaluating missed detection, false positive ratio and comparing the results to the manual procedure with sampling. In the evaluated nerve surface, a 0.9% of false positives was found, along with 6.36% of missed detections. The resulting histograms show strong correlation with those obtained by manual measure. The noise introduced by this method is significantly lower than the intrinsic sampling variability. This automatic method constitutes an original tool for morphometrical analysis.

  16. An Automatic Indirect Immunofluorescence Cell Segmentation System

    Yung-Kuan Chan


    Full Text Available Indirect immunofluorescence (IIF with HEp-2 cells has been used for the detection of antinuclear autoantibodies (ANA in systemic autoimmune diseases. The ANA testing allows us to scan a broad range of autoantibody entities and to describe them by distinct fluorescence patterns. Automatic inspection for fluorescence patterns in an IIF image can assist physicians, without relevant experience, in making correct diagnosis. How to segment the cells from an IIF image is essential in developing an automatic inspection system for ANA testing. This paper focuses on the cell detection and segmentation; an efficient method is proposed for automatically detecting the cells with fluorescence pattern in an IIF image. Cell culture is a process in which cells grow under control. Cell counting technology plays an important role in measuring the cell density in a culture tank. Moreover, assessing medium suitability, determining population doubling times, and monitoring cell growth in cultures all require a means of quantifying cell population. The proposed method also can be used to count the cells from an image taken under a fluorescence microscope.

  17. Automatic Test Pattern Generation for Digital Circuits

    S. Hemalatha


    Full Text Available Digital circuits complexity and density are increasing and at the same time it should have more quality and reliability. It leads with high test costs and makes the validation more complex. The main aim is to develop a complete behavioral fault simulation and automatic test pattern generation (ATPG system for digital circuits modeled in verilog and VHDL. An integrated Automatic Test Generation (ATG and Automatic Test Executing/Equipment (ATE system for complex boards is developed here. An approach to use memristors (resistors with memory in programmable analog circuits. The Main idea consists in a circuit design in which low voltages are applied to memristors during their operation as analog circuit elements and high voltages are used to program the memristor’s states. This way, as it was demonstrated in recent experiments, the state of memristors does not essentially change during analog mode operation. As an example of our approach, we have built several programmable analog circuits demonstrating memristor -based programming of threshold, gain and frequency. In these circuits the role of memristor is played by a memristor emulator developed by us. A multiplexer is developed to generate a class of minimum transition sequences. The entire hardware is realized as digital logical circuits and the test results are simulated in Model sim software. The results of this research show that behavioral fault simulation will remain as a highly attractive alternative for the future generation of VLSI and system-on-chips (SoC.

  18. Automatic Caption Generation for Electronics Textbooks

    Veena Thakur


    Full Text Available Automatic or semi-automatic approaches for developing Technology Supported Learning Systems (TSLS are required to lighten their development cost. The main objective of this paper is to automate the generation of a caption module; it aims at reproducing the way teachers prepare their lessons and the learning material they will use throughout the course. Teachers tend to choose one or more textbooks that cover the contents of their subjects, determine the topics to be addressed, and identify the parts of the textbooks which may be helpful for the students it describes the entities, attributes, role and their relationship plus the constraints that govern the problem domain. The caption model is created in order to represent the vocabulary and key concepts of the problem domain. The caption model also identifies the relationships among all the entities within the scope of the problem domain, and commonly identifies their attributes. It defines a vocabulary and is helpful as a communication tool. DOM-Sortze, a framework that enables the semi-automatic generation of the Caption Module for technology supported learning system (TSLS from electronic textbooks. The semiautomatic generation of the Caption Module entails the identification and elicitation of knowledge from the documents to which end Natural Language Processing (NLP techniques are combined with ontologies and heuristic reasoning.

  19. Automatic Detection of Electric Power Troubles (ADEPT)

    Wang, Caroline; Zeanah, Hugh; Anderson, Audie; Patrick, Clint; Brady, Mike; Ford, Donnie


    Automatic Detection of Electric Power Troubles (A DEPT) is an expert system that integrates knowledge from three different suppliers to offer an advanced fault-detection system. It is designed for two modes of operation: real time fault isolation and simulated modeling. Real time fault isolation of components is accomplished on a power system breadboard through the Fault Isolation Expert System (FIES II) interface with a rule system developed in-house. Faults are quickly detected and displayed and the rules and chain of reasoning optionally provided on a laser printer. This system consists of a simulated space station power module using direct-current power supplies for solar arrays on three power buses. For tests of the system's ablilty to locate faults inserted via switches, loads are configured by an INTEL microcomputer and the Symbolics artificial intelligence development system. As these loads are resistive in nature, Ohm's Law is used as the basis for rules by which faults are located. The three-bus system can correct faults automatically where there is a surplus of power available on any of the three buses. Techniques developed and used can be applied readily to other control systems requiring rapid intelligent decisions. Simulated modeling, used for theoretical studies, is implemented using a modified version of Kennedy Space Center's KATE (Knowledge-Based Automatic Test Equipment), FIES II windowing, and an ADEPT knowledge base.


    Siham AMROUCH


    Full Text Available In the last decade, ontologies have played a key technology role for information sharing and agents interoperability in different application domains. In semantic web domain, ontologies are efficiently used to face the great challenge of representing the semantics of data, in order to bring the actual web to its full power and hence, achieve its objective. However, using ontologies as common and shared vocabularies requires a certain degree of interoperability between them. To confront this requirement, mapping ontologies is a solution that is not to be avoided. In deed, ontology mapping build a meta layer that allows different applications and information systems to access and share their informations, of course, after resolving the different forms of syntactic, semantic and lexical mismatches. In the contribution presented in this paper, we have integrated the semantic aspect based on an external lexical resource, wordNet, to design a new algorithm for fully automatic ontology mapping. This fully automatic character features the main difference of our contribution with regards to the most of the existing semi-automatic algorithms of ontology mapping, such as Chimaera, Prompt, Onion, Glue, etc. To better enhance the performances of our algorithm, the mapping discovery stage is based on the combination of two sub-modules. The former analysis the concept’s names and the later analysis their properties. Each one of these two sub-modules is it self based on the combination of lexical and semantic similarity measures.

  1. A Tentative Research on Complexity of Automatic Programming


    In this paper, based on the following theoretical framework:Evolution ary Algorithms + Program Structures = Automatic Programming , some results on co mplexity of automatic programming for function modeling is given, which show tha t the complexity of automatic programming is an exponential function of the prob lem dimension N, the size of operator set |F| and the height of the pr ogram pars e tree H. Following this results, the difficulties of automatic programming are discussed. Some function models discovered automatically from database by evolut ionary modeling method are given, too.

  2. daptive Filter Used as a Dynamic Compensator in Automatic Gauge Control of Strip Rolling Processes

    N. ROMAN


    Full Text Available The paper deals with a control structure of the strip thickness in a rolling mill of quarto type (AGC – Automatic Gauge Control. It performs two functions: the compensation of errors induced by unideal dynamics of the tracking systems lead by AGC system and the control adaptation to the change of dynamic properties of the tracking systems. The compensation of dynamical errors is achieved through inverse models of the tracking system, implemented as adaptive filters.

  3. Presentation video retrieval using automatically recovered slide and spoken text

    Cooper, Matthew


    Video is becoming a prevalent medium for e-learning. Lecture videos contain text information in both the presentation slides and lecturer's speech. This paper examines the relative utility of automatically recovered text from these sources for lecture video retrieval. To extract the visual information, we automatically detect slides within the videos and apply optical character recognition to obtain their text. Automatic speech recognition is used similarly to extract spoken text from the recorded audio. We perform controlled experiments with manually created ground truth for both the slide and spoken text from more than 60 hours of lecture video. We compare the automatically extracted slide and spoken text in terms of accuracy relative to ground truth, overlap with one another, and utility for video retrieval. Results reveal that automatically recovered slide text and spoken text contain different content with varying error profiles. Experiments demonstrate that automatically extracted slide text enables higher precision video retrieval than automatically recovered spoken text.

  4. Prevalence of Epsilan wave in patients with arrhythmogenic right ventricular cardiomyopathy%致心律失常性右室心肌病患者Epsilon波的检出率

    王静; 居维竹; 陈凯; 曹克将; 杨兵; 陈明龙; 单其俊; 邹建刚; 陈椿; 张凤祥; 侯晓峰; 陈红武


    目的 探讨不同体表心电图记录方法对国人致心律失常性有室心肌病(arrhythmogenic right ventricular eardiomyopathy,ARVC)患者Epsilon波检出率的影响.方法 共人选ARVC患者32例,男性24例,女性8例,年龄18~70(42.3±13.3)岁.于安静仰卧位记录窦性心律情况下的标准12导联同步心电图(standard twelve leads electrocardiography,S-ECG)、右胸导联心电图(right precordial leads ECG,R-ECG)及Fontaine双极胸导联心电图(Fontaine bipolar precordial leads ECG,F-ECG)o Epsilon波判断标准为位于QRS波之后、sT段起始部的低波幅棘波、振荡波或平缓电位.结果 该组病例S-ECG、R-ECG及F-ECG对Epsilon波的检出率分别为37.5%、37.5%和50.0%,三种心电图记录方法之间Epsilon波检出率的比较差异无统计学意义(均为P>0.05).其中1例Epsilon波仅见于S-ECG,3例仅见于R-ECG,5例仅见于F-ECG.S-ECG联合R-ECG的检出率为50.0%,S-ECG联合F-ECG的检出率为56.3%,三种记录方法的联合检出率为65.6%,S-ECG联合F-ECG的枪出率与S-ECG相比明显提高(P<0.05),联合三种心电图记录方法的检出率与S-ECG相比有显著提高(P<0.01).结论 联合使用S-ECG、R-ECG及F-ECG三种心电图记录方法,可以显著提高ARVC患者Epsilon波的检出率,且三种记录方法之间可以相互补充.%Objective To investigate the prevalence of Epsilon wave in patients with arrhythmogenic right ventrieular cardiomyopathy (ARVC). Methods The Epsilon wave was detected in 32 patients [24 men, mean age (42.3±13.3) years] with ARVC using three different electrocardiography (ECG) recording methods: standard twelve leads ECG (S-ECG), right precordial leads ECG (R-ECG) and Fontaine bipolar precordiai leads ECG (F-ECG). The Epsilon wave was defined as wiggle, small spike wave and smooth potential between the end of the QRS complex and the beginning of the ST segment. Results Epsilon wave was detected in 37.5%, 37.5% and 50.0% patients with ARVC by S-ECG, R

  5. Forensic Automatic Speaker Recognition Based on Likelihood Ratio Using Acoustic-phonetic Features Measured Automatically

    Huapeng Wang


    Full Text Available Forensic speaker recognition is experiencing a remarkable paradigm shift in terms of the evaluation framework and presentation of voice evidence. This paper proposes a new method of forensic automatic speaker recognition using the likelihood ratio framework to quantify the strength of voice evidence. The proposed method uses a reference database to calculate the within- and between-speaker variability. Some acoustic-phonetic features are extracted automatically using the software VoiceSauce. The effectiveness of the approach was tested using two Mandarin databases: A mobile telephone database and a landline database. The experiment's results indicate that these acoustic-phonetic features do have some discriminating potential and are worth trying in discrimination. The automatic acoustic-phonetic features have acceptable discriminative performance and can provide more reliable results in evidence analysis when fused with other kind of voice features.

  6. Automatic stereotyping against people with schizophrenia, schizoaffective and affective disorders.

    Rüsch, Nicolas; Corrigan, Patrick W; Todd, Andrew R; Bodenhausen, Galen V


    Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-reported attitudes and emotional reactions. We therefore studied automatically activated reactions toward mental illness among 85 people with schizophrenia, schizoaffective or affective disorders as well as among 50 members of the general public, using a Lexical Decision Task to measure automatic stereotyping. Deliberately endorsed attitudes and emotional reactions were assessed by self-report. Independent of diagnosis, people with mental illness showed less negative automatic stereotyping than did members of the public. Among members of the public, stronger automatic stereotyping was associated with more self-reported shame about a potential mental illness and more anger toward stigmatized individuals. Reduced automatic stereotyping in the diagnosed group suggests that people with mental illness might not entirely internalize societal stigma. Among members of the public, automatic stereotyping predicted negative emotional reactions to people with mental illness. Initiatives to reduce the impact of public stigma and internalized stigma should take automatic stereotyping and related emotional aspects of stigma into account. Copyright © 2010 Elsevier B.V. All rights reserved.

  7. Automatic image classification for the urinoculture screening.

    Andreini, Paolo; Bonechi, Simone; Bianchini, Monica; Garzelli, Andrea; Mecocci, Alessandro


    Urinary tract infections (UTIs) are considered to be the most common bacterial infection and, actually, it is estimated that about 150 million UTIs occur world wide yearly, giving rise to roughly $6 billion in healthcare expenditures and resulting in 100,000 hospitalizations. Nevertheless, it is difficult to carefully assess the incidence of UTIs, since an accurate diagnosis depends both on the presence of symptoms and on a positive urinoculture, whereas in most outpatient settings this diagnosis is made without an ad hoc analysis protocol. On the other hand, in the traditional urinoculture test, a sample of midstream urine is put onto a Petri dish, where a growth medium favors the proliferation of germ colonies. Then, the infection severity is evaluated by a visual inspection of a human expert, an error prone and lengthy process. In this paper, we propose a fully automated system for the urinoculture screening that can provide quick and easily traceable results for UTIs. Based on advanced image processing and machine learning tools, the infection type recognition, together with the estimation of the bacterial load, can be automatically carried out, yielding accurate diagnoses. The proposed AID (Automatic Infection Detector) system provides support during the whole analysis process: first, digital color images of Petri dishes are automatically captured, then specific preprocessing and spatial clustering algorithms are applied to isolate the colonies from the culture ground and, finally, an accurate classification of the infections and their severity evaluation are performed. The AID system speeds up the analysis, contributes to the standardization of the process, allows result repeatability, and reduces the costs. Moreover, the continuous transition between sterile and external environments (typical of the standard analysis procedure) is completely avoided. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. [Automatization of the workplace of radiologist].

    Belikova, T P; Lashin, V V; Iashunskaia, N I


    The authors propose and implement a roentgenologist's IBM PC/AT-compatible computer-aided automatic working place designed for the digital processing and analysis of medical introscopic images. The two-levelled architecture of APM-BP software allows one to optimize the speed of computations and to apply as computer technologies the know-how and experience gained in solving specific problems in the analysis of informative features of medical images. A procedure for the digital processing of linear pulmonary tomograms by using the designed working place in order to solve the problems of preclinical diagnosis of peripheral lung cancer is described.

  9. Automatic Planning of External Search Engine Optimization

    Vita Jasevičiūtė


    Full Text Available This paper describes an investigation of the external search engine optimization (SEO action planning tool, dedicated to automatically extract a small set of most important keywords for each month during whole year period. The keywords in the set are extracted accordingly to external measured parameters, such as average number of searches during the year and for every month individually. Additionally the position of the optimized web site for each keyword is taken into account. The generated optimization plan is similar to the optimization plans prepared manually by the SEO professionals and can be successfully used as a support tool for web site search engine optimization.

  10. Personality in speech assessment and automatic classification

    Polzehl, Tim


    This work combines interdisciplinary knowledge and experience from research fields of psychology, linguistics, audio-processing, machine learning, and computer science. The work systematically explores a novel research topic devoted to automated modeling of personality expression from speech. For this aim, it introduces a novel personality assessment questionnaire and presents the results of extensive labeling sessions to annotate the speech data with personality assessments. It provides estimates of the Big 5 personality traits, i.e. openness, conscientiousness, extroversion, agreeableness, and neuroticism. Based on a database built on the questionnaire, the book presents models to tell apart different personality types or classes from speech automatically.

  11. Automatic alignment of a Michelson interferometer

    Barone, F.; Di Fiore, L.; Milano, L.; Russo, G.; Solimeno, S. (Inst. Nazionale di Fisica Nucleare, Napoli (IT))


    This paper describes the control system for the automatic control of a very large dual-wave Michelson interferometer to be used in the VIRGO experiment, a gravitational wave search in the band 10 to 3000 Hz. The system is mainly based on a VME bus architecture for the local controls, on which numeric control system based on digital filters are implemented. The authors describe these control systems, and the way they are linked together to form the global control system, in a hierarchical configuration.

  12. Automatic control algorithm effects on energy production

    Mcnerney, G. M.


    A computer model was developed using actual wind time series and turbine performance data to simulate the power produced by the Sandia 17-m VAWT operating in automatic control. The model was used to investigate the influence of starting algorithms on annual energy production. The results indicate that, depending on turbine and local wind characteristics, a bad choice of a control algorithm can significantly reduce overall energy production. The model can be used to select control algorithms and threshold parameters that maximize long term energy production. The results from local site and turbine characteristics were generalized to obtain general guidelines for control algorithm design.

  13. Capacitance sensor for automatic soil retreat measurements

    GU Jun; YANG Juan; YIN Wu-liang; WANG Chao; WANG Hua-xiang; LIU Ze; CHENG Su-sen


    To continuously monitor the soil retreat due to erosion in field, provide valuable information about the erosion processes and overcome the disadvantages of inefficiency, high time-consumption and labor-intensity of existing methods, this paper describes a novel capacitance sensor for measuring the soil retreat. A capaci-tance sensor based probe is proposed, which can measure the depth of the soil around it automatically and the data can be recorded by a data logger. Experimental results in the lab verify its usefulness.

  14. Length Scales in Bayesian Automatic Adaptive Quadrature

    Adam Gh.


    Full Text Available Two conceptual developments in the Bayesian automatic adaptive quadrature approach to the numerical solution of one-dimensional Riemann integrals [Gh. Adam, S. Adam, Springer LNCS 7125, 1–16 (2012] are reported. First, it is shown that the numerical quadrature which avoids the overcomputing and minimizes the hidden floating point loss of precision asks for the consideration of three classes of integration domain lengths endowed with specific quadrature sums: microscopic (trapezoidal rule, mesoscopic (Simpson rule, and macroscopic (quadrature sums of high algebraic degrees of precision. Second, sensitive diagnostic tools for the Bayesian inference on macroscopic ranges, coming from the use of Clenshaw-Curtis quadrature, are derived.

  15. Automatic Computation of Cross Sections in HEP

    Yuasa, F; Ishikawa, T; Jimbo, M; Kaneko, T; Kato, K; Kawabata, S; Kon, T; Kurihara, Y; Kuroda, M; Nakazawa, N; Shimizu, Y; Tanaka, H


    For the study of reactions in High Energy Physics (HEP) automatic computation systems have been developed and are widely used nowadays. GRACE is one of such systems and it has achieved much success in analyzing experimental data. Since we deal with the cross section whose value can be given by calculating hundreds of Feynman diagrams, we manage the large scale calculation, so that effective symbolic manipulation, the treat of singularity in the numerical integration are required. The talk will describe the software design of GRACE system and computational techniques in the GRACE.

  16. Automatic Airway Deletion in Pulmonary Segmentation

    WANG Ping; ZHUANG Tian-ge


    A method of removing the airway from pulmonary segmentation image was proposed. This method firstly segments the image into several separate regions based on the optimum threshold and morphological operator,and then each region is labeled and noted with its mean grayscale. Therefore, most of the non-lung regions can be removed according to the tissue's Hounsfield units (HU) and the imaging modality. Finally, the airway region is recognized and deleted automatically through using the priori information of its HU and size. This proposed method is tested using several clinical images, yielding satisfying results.

  17. The CHilean Automatic Supernova sEarch

    Hamuy, M.; Pignata, G.; Maza, J.


    The CHilean Automatic Supernova sEarch (CHASE) project began in 2007 with the goal to discover young, nearby southern supernovae in order to (1) better understand the physics of exploding stars and their progenitors, and (2) refine the methods to derive extragalactic distances. During the first...... four years of operation, CHASE has produced more than 130 supernovae, being the most successful project of its type in the southern hemisphere. Here we describe the project and present illustrative examples of CHASE discoveries of particular relevance....

  18. Spatial Text Visualization Using Automatic Typographic Maps.

    Afzal, S; Maciejewski, R; Jang, Yun; Elmqvist, N; Ebert, D S


    We present a method for automatically building typographic maps that merge text and spatial data into a visual representation where text alone forms the graphical features. We further show how to use this approach to visualize spatial data such as traffic density, crime rate, or demographic data. The technique accepts a vector representation of a geographic map and spatializes the textual labels in the space onto polylines and polygons based on user-defined visual attributes and constraints. Our sample implementation runs as a Web service, spatializing shape files from the OpenStreetMap project into typographic maps for any region.

  19. Automatic Detection of Omissions in Translations

    Melamed, I D


    ADOMIT is an algorithm for Automatic Detection of OMIssions in Translations. The algorithm relies solely on geometric analysis of bitext maps and uses no linguistic information. This property allows it to deal equally well with omissions that do not correspond to linguistic units, such as might result from word-processing mishaps. ADOMIT has proven itself by discovering many errors in a hand-constructed gold standard for evaluating bitext mapping algorithms. Quantitative evaluation on simulated omissions showed that, even with today's poor bitext mapping technology, ADOMIT is a valuable quality control tool for translators and translation bureaus.

  20. Automatic Sarcasm Detection in Twitter Messages

    Ræder, Johan Georg Cyrus Mazaher


    In the past decade, social media like Twitter have become popular and a part of everyday life for many people. Opinion mining of the thoughts and opinions they share can be of interest to, e.g., companies and organizations. The sentiment of a text can be drastically altered when figurative language such as sarcasm is used. This thesis presents a system for automatic sarcasm detection in Twitter messages. To get a better understanding of the field, state-of-the-art systems fo...