WorldWideScience

Sample records for armed forces radiobiology

  1. 77 FR 68155 - The Armed Forces Radiobiology Research Institute TRIGA Reactor: Facility Operating License No. R-84

    Science.gov (United States)

    2012-11-15

    ... NRC's E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to... filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28, 2007) apply to appeals of NRC... COMMISSION The Armed Forces Radiobiology Research Institute TRIGA Reactor: Facility Operating License No....

  2. Biological effects of embedded depleted uranium (DU). Summary of Armed Forces Radiobiology Research Institute research

    International Nuclear Information System (INIS)

    The Persian Gulf War resulted in injuries of US Coalition personnel by fragments of depleted uranium (DU). Fragments not immediately threatening the health of the individuals were allowed to remain in place, based on long-standing treatment protocols designed for other kinds of metal shrapnel injuries. However, questions were soon raised as to whether this approach is appropriate for a metal with the unique radiological and toxicological properties of DU. The Armed Forces Radiobiology Research Institute (AFRRI) is investigating health effects of embedded fragments of DU to determine whether current surgical fragment removal policies remain appropriate for this metal. These studies employ rodents implanted with DU pellets as well as cultured human cells exposed to DU compounds. Results indicate uranium from implanted DU fragments distributed to tissues far-removed from implantation sites, including bone, kidney, muscle, and liver. Despite levels of uranium in the kidney that were nephrotoxic after acute exposure, no histological or functional kidney toxicity was observed. However, results suggest the need for further studies of long-term health impact, since DU was found to be mutagenic, and it transformed human osteoblast cells to a tumorigenic phenotype. It also altered neurophysiological parameters in rat hippocampus, crossed the placental barrier, and entered fetal tissue. This report summarizes AFRRI's depleted uranium research to date

  3. Safety-Evaluation Report related to the renewal of the operating license for the research reactor at the Armed Forces Radiobiology Research Institute. Docket No. 50-170

    International Nuclear Information System (INIS)

    Supplement 1 to the Safety Evaluation Report related to the renewal of the operating license for the research reactor at the Armed Forces Radiobiology Research Institute has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The reactor facility is located in Montgomery County, Maryland. This supplement reports on the status of the licensee's emergency plan that had not been reviewed at the time the Safety Evaluation Report (NUREG-0882) was published

  4. AFRRI (Armed Forces Radiobiology Research Institute) reports, April-June 1985. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The following titles are included in this collection of reprints: Presence of a high-affinity Ca(s+) - and Mg(2+) - dependent ATPase in rat peritoneal mast-cell membranes; Prostanoid production by lipopolysaccharide stimulated Kupffer cells; Antihistamines block radiation-induced increased intestinal blood flow in canines; WR-2721 inhibition of radiation-induced prostaglandin excretion in rats; Effects of mixed neutron-gamma total-body irradiation on physical activity performance of rhesus monkeys; Immunologic and hematologic perturbations in models of combined injury; Hematopoiesis in conventional mice after wound trauma; Carrier generation recombination, and transport in organic crystals; Energy transfer and molecular weight effects on polymer luminescence. Keywords: Radiobiology; Military research.

  5. Radiobiology

    International Nuclear Information System (INIS)

    This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, scientific workers and physicians. (author)

  6. Modernization of African Armed Forces

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    2015-01-01

    Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa.......Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa....

  7. 78 FR 30731 - Armed Forces Day, 2013

    Science.gov (United States)

    2013-05-22

    ... hundred and thirty- seventh. (Presidential Sig.) [FR Doc. 2013-12402 Filed 5-21-13; 11:15 am] Billing code..., liberty, and the pursuit of happiness. And on Armed Forces Day, we honor those who serve bravely and... the United States at their homes on Armed Forces Day, and I urge citizens to learn more about...

  8. Homosexuality in the Dutch Armed Forces 2006

    NARCIS (Netherlands)

    Anna Adolfsen; Saskia Keuzenkamp; m.m.v. Linda Mans

    2006-01-01

    Original title: Uniform uit de kast. This study looks at the attitudes of defence personnel to homosexuality. How do members of the military view homosexual colleagues? Can gays and lesbians working in the armed forces be open about their sexual preferences? Do they regard the armed forces as a gay

  9. Homosexuality in the Dutch Armed Forces 2006

    OpenAIRE

    Anna Adolfsen; Saskia Keuzenkamp; m.m.v. Linda Mans

    2006-01-01

    Original title: Uniform uit de kast. This study looks at the attitudes of defence personnel to homosexuality. How do members of the military view homosexual colleagues? Can gays and lesbians working in the armed forces be open about their sexual preferences? Do they regard the armed forces as a gay-friendly workplace, or do they have lots of negative experiences? At the request of the State Secretary for Defence, the Netherlands Institute for Social Research/SCP carried out a study on the acc...

  10. Diversity in the Danish Armed Forces

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John; Pradhan-Blach, Flemming; Larsen, Esben Salling; Larsen, Josefine Kühnel

    with more diverse militaries, such as the United States, Great Britain, and Canada, include recognition of diversity as a societal imperative to sustain the legitimacy of the armed forces, the necessity of systematically collecting and reporting personnel data to guide policy, the necessity of patience...

  11. Optimizing Armed Forces Capabilities for Hybrid Warfare – New Challenge for Slovak Armed Forces

    Directory of Open Access Journals (Sweden)

    Peter PINDJÁK

    2015-09-01

    Full Text Available The paper deals with the optimization of military capabilities of the Slovak Armed Forces for conducting operations in a hybrid conflict, which represents one of the possible scenarios of irregular warfare. Whereas in the regular warfare adversaries intend to eliminate the centers of gravity of each other, most often command and control structures, in irregular conflicts, the center of gravity shifts towards the will and cognitive perception of the target population. Hybrid warfare comprises a thoroughly planned combination of conventional military approaches and kinetic operations with subversive, irregular activities, including information and cyber operations. These efforts are often accompanied by intensified activities of intelligence services, special operation forces, and even mercenary and other paramilitary groups. The development of irregular warfare capabilities within the Slovak Armed Forces will require a progressive transformation process that may turn the armed forces into a modern and adaptable element of power, capable of deployment in national and international crisis management operations.

  12. The professionalisation of the Netherlands armed force

    OpenAIRE

    Van Veldhuizen-Rothenbuecher, Ida

    2001-01-01

    The fall of the Berlin Wall and the end of the Cold War led in 1991 to the decision to gradually reduce and restructure the Netherlands armed forces. It was process consisting of dozens of reorganisations. The idea was that the reorganisation and reduction would go hand in hand, not only operationally but also financially. Firstly, only one in three men were actually still called up in order to fulfil conscription duties lasting more or less a year. There was one more condition for the transf...

  13. Professional armed forces new trend in Europe : transformation of the Czech armed forces

    OpenAIRE

    Zold, Zoltan

    2002-01-01

    Approved for public release; distribution is unlimited In 2001 the Czech Republic decided to abandon conscription in favor of professional armed forces. Western European countries are following the same trend, since the new security environment requires quickly deployable, highly skilled and well-equipped forces. The current round of reforms started with Belgium and Netherlands, and have seen followed by France, Spain, Italy and Portugal. These countries are beneficiary from experience in ...

  14. Information operations, an evolutionary step for the Mexican Armed Forces

    OpenAIRE

    Schulz, David Vargas

    2007-01-01

    This thesis will focus on the Mexican Armed Force's ability to deal with existing and future unconventional threats and insurgencies. The modern Mexican Armed Forces are the result of an enduring evolutionary process, which has made the necessary changes to deal with the emerging threats against the state. Mexico's criminal threat has evolved because of 9/11 and because of the U.S.-led crackdown on Colombian drug cartels. Mexico's modern adversary is well versed in waging mass media campa...

  15. Procurement, Storage and Distribution of Foodstuff in the Armed Forces

    OpenAIRE

    Y. D. Sahasrabuddhe

    1984-01-01

    The problem of procuring, storing and distributing foodstuffs to the Armed Forces in India is a stupendous task because of the wide variations interrains and climatic conditions and the varied food habits of the people. It is all the more exacting as the processed food industry is still in its infancy. Because of the stringent quality control requirements of the Armed Forces, the food processing industry in India is not willing to undertake supplies to the Defence services. The problems and h...

  16. SELECTION AND TRAINING OF LEADERS IN THE TURKISH ARMED FORCES

    OpenAIRE

    Suat Begec

    2013-01-01

    Leadership is the most frequently studied concept at the beginning of every period of history. Leader is a commander and the leadership is a command the unit in military sense. The majority of studies about leadership are conducted in the armed forces. Many countries have designed their armies in accordance with these studies. The Turkish Armed Forces (TAF) believes the importance of these studies and designs education systems and training in the selection and training of the leaders. The big...

  17. A model of psychological resilience for the Netherlands Armed Forces

    NARCIS (Netherlands)

    Kamphuis, W.; Venrooij, W.; Berg, C. van den

    2012-01-01

    In the current study, a model of psychological resilience was developed for the Netherlands Armed Forces and a number of important relations were tested using a longitudinal design. The model of resilience was based on a systematic literature review of resilience in high-risk professions and intervi

  18. AFRRI (Armed Forces Radiobiology Research Institute) reports, January, February and March 1988. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    A possible mechanism by which disodium cromoglycate (DSCG) prevents a decrease in regional cerebral blood flow but not hypotension in primates following whole body gamma irradiation was studied. Several studies have implicated superoxide radicals in intestinal and cerebral vascular disorders following ischemia and ionizing radiation, respectively, The superoxide radical is formed during radiolysis in the reaction between hydrated electrons and dissolved oxygen. For this reason, the efficiency of DSCG to scavenge hydrated electrons and possibly prevent the formation of the superoxide radical was studied. The results show that DSCG is an efficient hydrated-electrons scavenger and may effectively compete with oxygen for hydrated electrons preventing the radiolytic formation of the superoxide radicals.

  19. AFRRI (Armed Forces Radiobiology Research Institute) reports, April-June 1989. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1989-07-01

    This volume contains AFRRI Scientific Reports Sr89-15 through SR89-25 for April-June 1989. Subjects include: Radiation quality and rat motor performance; Gamma-radiation affects: active electrolyte transport by rabbit ileum II; Correlation of alanine and theophylline response with morphology; effects of iron particles on behavioral and brain function: Initial studies; Correlative motor behavioral and striatal dopaminergic alterations induced by Fe iron radiation; The effect of radiation on DNA methylation; Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia; Oxidation damage in the guinea pig hippocampal slice; Radiation-induced volatile hydrocarbon production in platelets: Long-term culture of canine bone marrow cells; Radioprotection of mouse hematopoietic stem cells by leukotriene A4 and lipoxin B4; and Selective association and transport of Campylobacter jejuni through M cells of rabbit Peyer's patches.

  20. AFRRI (Armed Forces Radiobiology Research Institute) reports, October, November, December 1986. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    Contents include: neutron-induced free radicals in oriented DNA; evidence of de novo membrane generation in the mechanism of mast-cell secretary granule activation; dose dependent radiation-induced hypotension in the canine; formulation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide; hepotabiliary kinetics after whole-body irradiation; the role of endogenous prostaglandins in the regulation of gastric secretion in rhesus monkeys; circadian rhythms in catecholamine metabolites and cyclic nucleotide production; relationships between behavioral rhythms, plasma corticosterone and hypothalamic circadian rhythms; a novel interaction of diethyldithiocarbamate with the glutathione/glutathione peroxidase system; inhibition of glutathione peroxidase and glutathione transferase in mouse liver by misonidazole; organophosphate-induced histamine release from mast cells; hemopoietic effects of intravenous soluble glucan administration; single-electrode voltage clamp in mammalian electrophysiology; prostaglandin-mediated suppression of delayed-type hypersensitivity to infected erthyrocytes during babesia microti infection in mice; gastric protection by sucralfate; urinary excretion of cyclic nucleotides, creatinine prostaglandin E2 and thromboxane B2 from mice exposed to whole-body irradiation from an enhanced neutron field; performance characteristics of a high-level solid-state personnel dosimetry system in pulsed radiation environments; development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells.

  1. SELECTION AND TRAINING OF LEADERS IN THE TURKISH ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Suat Begec

    2013-10-01

    Full Text Available Leadership is the most frequently studied concept at the beginning of every period of history. Leader is a commander and the leadership is a command the unit in military sense. The majority of studies about leadership are conducted in the armed forces. Many countries have designed their armies in accordance with these studies. The Turkish Armed Forces (TAF believes the importance of these studies and designs education systems and training in the selection and training of the leaders. The biggest advance in the TAF was being held during the period of education and training improvement. This study investigates to bring that issue into focus and offers a whole social science agenda for leadership in the TAF related research. In this article exploratory research was applied and military history specimens were used. The results of the study demonstrate the geographically powerful armed forces are always needed. A powerful army can indicate the presence of strong leadership. The criteria determined by the selection and training of staff will be one of the most essential tasks that will lead the TAF into the future. These results, however, need further work to validate reliability.

  2. SPORT, HEALTH AND WORK EFFICIENCY IN SLOVENIAN ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Tušak Matej,

    2012-06-01

    Full Text Available The basic aim of the research was to discover the meaning of sport, its value among the soldiers and officers and its motivational effect and the correlation between sport in the army and general health and satisfaction with work and life. We tried to research the positive effects of sport on the work efficiency in Slovenian Armed Forces. Different sport psychological measurements and tests have been in research. We used Self-motivation Inventory, Participation (in sport Motivation Inventory, Work Motivation, General Health Questionnaire, Attitudes Toward Sport, Work Efficency Scale, Satisfaction with Life Scale and Body Mass Index. 141 subjecs were involved into the researh (75 sodiers and 66 officers in Slovenian Armed Forces. The results showed many useful data. There is a positive connection between attitudes toward sport and general health and satisfaction in work. There is also a positive connection between sport attitudes and work efficiency. The main sport motives for the employers in Slovenian Armed Forces are: they like friendship and brotherhood through sport, they want to stay fit and they want to learn new sport skills. Through these results we can confirm very positive effects of sport on the general life and work in the Army. New researches should follow to discover more directions for practical suggestions.

  3. Force production and spatial arm coordination profile in arm crawl swimming in a fixed position.

    Science.gov (United States)

    Karsai, István; Garrido, N; Louro, H; Leitão, L; Magyar, F; Alves, F; Silva, A

    2010-12-01

    This study analyzed the relationship between mechanical force production and spatial arm position of the swimming movement for each side of the swimmer. Eight internationally recognized male swimmers performed fix positioned arm only swimming with a dynamometer synchronized with underwater cameras. The upper arm positions (α in side, β in frontal view) and the elbow angles (γ in 3D) were determined at the moment where the force production reached the peak (Fmax) and the maximal values of rate of force development (RFDmax). RFDmax and α values showed significant differences between the sides (P<0.05). To show the motion integration structure of the performance, Multiple Regression Analysis (MRA) was employed separately for both sides. For the criterion variable, the impulse of force (ImpF50%) was calculated. The defined parameters as the mechanical and spatial predictor system were used for the model. The results of the MRA showed that the predictor system yielded the model structure of the variables that explain the criterion variables for ImpF50% by the dominant (P=0.007) and by the nondominant side (P=0.001), respectively. The alternate contribution of the variables to the models can objectively express the performance difference between the two sides of the swimmer. PMID:21138814

  4. Direction of force generated by the inner row of dynein arms on flagellar microtubules

    OpenAIRE

    1987-01-01

    Our goal was to determine the direction of force generation of the inner dynein arms in flagellar axonemes. We developed an efficient means of extracting the outer row of dynein arms in demembranated sperm tail axonemes, leaving the inner row of dynein arms structurally and functionally intact. Sperm tail axonemes depleted of outer arms beat at half the beat frequency of sperm tails with intact arms over a wide range of ATP concentrations. The isolated, outer arm-depleted axonemes were induce...

  5. Rapid adaptation to Coriolis force perturbations of arm trajectory

    Science.gov (United States)

    Lackner, J. R.; Dizio, P.

    1994-01-01

    1. Forward reaching movements made during body rotation generate tangential Coriolis forces that are proportional to the cross product of the angular velocity of rotation and the linear velocity of the arm. Coriolis forces are inertial forces that do not involve mechanical contact. Virtually no constant centrifugal forces will be present in the background when motion of the arm generates transient Coriolis forces if the radius of body rotation is small. 2. We measured the trajectories of arm movements made in darkness to a visual target that was extinguished as movement began. The reaching movements were made prerotation, during rotation at 10 rpm in a fully enclosed rotating room, and postrotation. During testing the subject was seated at the center of the room and pointed radially. Neither visual nor tactile feedback about movement accuracy was present. 3. In experiment 1, subjects reached at a fast or slow rate and their hands made contact with a horizontal surface at the end of the reach. Their initial perrotary movements were highly significantly deviated relative to prerotation in both trajectories and end-points in the direction of the transient Coriolis forces that had been generated during the reaches. Despite the absence of visual and tactile feedback about reaching accuracy, all subjects rapidly regained straight movement trajectories and accurate endpoints. Postrotation, transient errors of opposite sign were present for both trajectories and endpoints. 4. In a second experiment the conditions were identical except that subjects pointed just above the location of the extinguished target so that no surface contact was involved. All subjects showed significant initial perrotation deviations of trajectories and endpoints in the direction of the transient Coriolis forces. With repeated reaches the trajectories, as viewed from above, again became straight, but there was only partial restoration of endpoint accuracy, so that subjects reached in a straight

  6. STRATEGIC MANAGEMENT OF HUMAN RESOURCE AND THE SLOVAK ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Jaroslav NEKORANEC

    2014-04-01

    Full Text Available Human resource management is an important area of strategic management of the organization which focuses on everything that concerns people. The main role of human resource management is to contribute to organizational performance and its continuous improvement. In order to fulfill the aims and objectives of the organization, it is necessary that organization top management has a clear-cut view of human resource management strategies that would work in practice. One of the most important and most challenging aspects of human resource management can be applied also in organizations characterized by specific features such as the Armed Forces of the Slovak Republic.

  7. Basic radiobiology

    International Nuclear Information System (INIS)

    Radiobiology, a branch of science concerned with the action of ionizing radiation on biological tissues and living organisms, is a combination of two disciplines: radiation physics and biology. For use in radiobiology and radiation protection the physical quantity that is useful for defining the quality of an ionizing radiation beam is the linear energy transfer (LET). In contrast to the stopping power, which focuses attention on the energy loss by an energetic charged particle moving through a medium, the LET focuses attention on the linear rate of energy absorption by the absorbing medium as the charged particle traverses the medium. When cells are exposed to ionizing radiation the standard physical effects between radiation and the atoms or molecules of the cells occur first and the possible biological damage to cell functions follows later. The biological effects of radiation result mainly from damage to the DNA, which is the most critical target within the cell; however, there are also other sites in the cell that, when damaged, may lead to cell death

  8. Human arm posture prediction in response to isometric endpoint forces.

    Science.gov (United States)

    Davoudabadi Farahani, Saeed; Andersen, Michael Skipper; de Zee, Mark; Rasmussen, John

    2015-11-26

    The ability to predict the musculoskeletal response to external loads has multiple applications for the design of machines with a human interface and for the prediction of outcomes of musculoskeletal interventions. In this study, we applied an inverse-inverse dynamics technique to investigate its ability to predict arm posture in response to isometric hand forces. For each subject, we made a three-dimensional musculoskeletal model using the AnyBody Modelling System (AMS). Then, we had each subject-specific model hold a weight anteriorly to the right shoulder joint at a distance of half of the arm length. We selected the glenohumeral abduction angle (GHAA) as the only free parameter. Subsequently, we used inverse-inverse dynamics to find the optimal GHAA that minimised a performance criterion with physiological constraints. In this study, we investigated the performance of two different objective functions: summation of squared muscle activity (SSMA) and summation of squared normalised joint torques (SSNJT). To validate the simulation results, arm posture responses to different isometric downward hand forces were measured for six healthy male subjects. Five trials were performed for each loading condition. The results showed that, with an increase in hand load, there was a reduced GHAA in all subjects. Another interesting finding was that self-selected postures for lighter tasks varied more than postures for heavier tasks for all subjects. To understand this, we investigated the curvature of the objective function as a function of the load and observed an increased curvature with increased load. This may explain the reduced intra-subject variations observed for increasing loads. PMID:26482735

  9. OPTIMIZATION OF FINANCIAL PERSONNEL NUMBER IN ARMED FORCES OF THE REPUBLIC OF BELARUS

    OpenAIRE

    A. V. Bolshakova

    2014-01-01

    The paper considers a problem pertaining to reduction of the Armed Forces of the Republic of Belarus and necessity to carry out economically reasonable reforms optimizing strength of financial personnel with the purpose to decrease its number but without undermining financial and operational activities of the Armed Forces as a whole. It has been proposed to optimize strength of financial personnel in the Armed Forces while executing organizational staff transformations such as introduction of...

  10. Conventional armed forces in Europe: Technology scenario development

    Energy Technology Data Exchange (ETDEWEB)

    Houser, G.M.

    1990-07-01

    In January 1986, the Soviet Union's Mikhail Gorbachev proposed elimination of all nuclear weapons by the year 2000. In April of that year, Mr. Gorbachev proposed substantial reductions of conventional weapons in Europe, from the Atlantic Ocean to the Ural Mountains, including reductions in operational-tactical nuclear weapons. In May 1986, the North Atlantic Treaty Organization (NATO) responded with the Brussels Declaration on Conventional Arms Control,'' which indicated readiness to open East/West discussions on establishing a mandate for negotiating conventional arms control throughout Europe. The Group of 23,'' which met in Vienna beginning in February 1987, concluded the meeting in January 1989 with a mandate for the Conventional Armed Forced in Europe (CFE) negotiations. On 6 March 1989, CFE talks began, and these talks have continued through six rounds (as of April 1990). Although US President George Bush, on 30 May 1989, called for agreement within six months to a year, and the Malta meeting of December 1989 called for completion of a CFE agreement by the end of 1990, much remains to be negotiated. This report provides three types of information. First, treaty provisions brought to the table by both sides are compared. Second, on the basis of these provisions, problem areas for each of the provision elements are postulated and possible scenarios for resolving these problem areas are developed. Third, the scenarios are used as requirements for tasks assigned program elements for possible US implementation of a CFE treaty. As progress is achieved during the negotiations, this report could be updated, as necessary, in each of the areas to provide a continuing systematic basis for program implementation and technology development. 8 refs.

  11. DRUG USE ATTITUDE OF TURKISH ARMED FORCES PILOTS

    Directory of Open Access Journals (Sweden)

    Ahmet SEN

    Full Text Available Introduction: Because of the dangers in the nature of flight, pilots have to fly in perfect medical conditions. Besides the undesirable effects of the diseases, side effects of the medications used in the treatment might also risk flight safety. In this study, we investigated the drug use attitude of Turkish Armed Forces pilots. Material-Method: In order to investigate their drug use attitude, a questionnaire was given to 408 pilots at GATA Aerospace Medical Center. Drug use attitude, drugs used by pilots and side effects were questioned. Results: 41 % of pilots reported that they used drugs during active flying. But the drug use rate of Army pilots was 57 %, which was higher than the Air Force and Navy pilots. The most common used drugs were analgesics. Conclusion: It is obvious that pilots might use drugs without informing their flight surgeon. Flight surgeons should always educate the pilots about the importance and dangers of self-medication. [TAF Prev Med Bull 2004; 3(9.000: 213-220

  12. Cancer radiobiology

    International Nuclear Information System (INIS)

    The work i have done in this dissertation, was mainly aimed at the literature review of radiotherapy radiobiology discussing the cure of tumours with ionizing radiation, from both the biological and physical point of view. The first chapter an introduction about the radiotherapy and includes: definition, working dose, benefit of radiotherapy, risk of radiotherapy, external and internal radiotherapy and treatment planing. In chapter two the theories of radiobiology and main effects caused by the radiation in the interaction with the biological matter were explained, the damages caused by the use of low and high LET (linear energy transfer) particles to mammalian cells were discussed. And discuss a therapeutic advantage may be gained by one of four hypothetical mechanism: repair the damage of DAN, so when sublethal injury can be repaired if no further hits are sustained. Also the reoxygenation of tumor is important for its effects on stabilization of free radicals produced by ionizing radiation. Hypoxic cells generally require an increased dose of radiation for lethal effect, redistribution, within the cell cycle depends on location of cells and their radiosensitivity also cells undergoing DNA synthesis, the S phase, are much more radioresistant than cells in other phase of the cell cycle, and repopulation of tumor cells is indicator of the surviving cells respond by increased regeneration or repopulation. Repopulation is a greater problem with rapidly proliferating tumors than slower growing neoplasms. These mechanisms are known as the classical four R's of radiation biology. One of the important applications of radiobiology is the radiotherapy and cancer treatment, experimental and theoretical studies in radiation biology contribute to the development of radiotherapy, in this dissertation we discussed the dose response relation so as the size of the tumor increases, and the dose needed for local control like wise increases, the risk of injury to normal tissue

  13. Enviroment of reform process and profesionalisation of Armed Forces – the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Laštovková, Jitka

    Budapest : Ministry of Defence of Republic of Hungary, 2005 - (Kozma, G.), s. 87-100 Institutional research plan: CEZ:AV0Z70280505 Keywords : armed forces * public opinion * professinalisation Subject RIV: AO - Sociology, Demography

  14. Gender Integration and the Swedish Armed Forces:The Case of Sexual Harassment and Prostitution

    OpenAIRE

    Gustafsson, Daniel Marcus Sunil

    2006-01-01

    This paper discusses different gender aspects of the Swedish Armed Forces with specific references to sexual harassment and prostitution. By using the concept of Hegemonic Masculinity, sexual harassment of the women in the Swedish Armed Forces is explained in terms of a need of the men within the organisation to reinforce the notion of women as inferior and subordinate to men, whereby the external hegemony is believed to be restored. Likewise, male Swedish peacekeepers’ demand for prostitutio...

  15. Efficiency and productivity in the operational units of the armed forces

    OpenAIRE

    Hanson, Torbjørn

    2012-01-01

    Most nations spend a considerable part of their gross domestic product (GDP) on defense. However, no previous study has addressed the productivity and efficiency of the core area of the armed forces, operational units, using Data Envelopment Analysis (DEA). Introducing a model for the production process of an operational unit, productivity and efficiency are estimated by DEA for units of one branch of the Norwegian armed forces. Small samples are a characteristic of DEA studies in the militar...

  16. Optimal arm posture control and tendon traction forces of a coupled tendon-driven manipulator

    International Nuclear Information System (INIS)

    In this study, the optimum arm posture of a coupled tendon-driven multijoint manipulator arm (or CT Arm) at maximum payload output was derived and the corresponding tendon traction forces were also analyzed, during management of a heavy payload by the manipulator in a gravity environment. The CT Arm is special tendon traction transmission mechanism in which a pair of tendons used to drive a joint is pulled from base actuators via pulleys mounted on the base-side joints. This mechanism enables optimal utilization of the coupled drive function of tendon traction forces and thus enables the lightweight manipulator to exhibit large payload capability. The properties of the CT Arm mechanism are elucidated by the proposed optimal posture control scheme. Computer simulation was also executed to verify the validity of the proposed control scheme. (author)

  17. Automatic identification technology tracking weapons and ammunition for the Norwegian Armed Forces

    OpenAIRE

    Lien, Tord Hjalmar.

    2011-01-01

    Approved for public release; distribution is unlimited. The purpose of this study is to recommend technology and solutions that improve the accountability and accuracy of small arms and ammunition inventories in the Norwegian Armed Forces (NAF). Radio Frequency Identification (RFID) and Item Unique Identification (IUID) are described, and challenges and benefits of these two major automatic identification technologies are discussed. A case study for the NAF is conducted where processes a...

  18. Ways of increasing the safety of small arms employment by law enforcement forces

    OpenAIRE

    Біленко, Олександр Іванович; Кириченко, Олександр Олександрович

    2014-01-01

    Various law enforcement forces play an important role in ensuring state law and order. The tasks of these forces differ greatly, ranging from national defense to protection of life, health and rights of individual citizens. The difference in goals and terms of their achievement is reflected in the ways of performing tasks and constraints, imposed in this case. The purpose of arms employment by the law enforcement forces is to stop an offense that prevents losses among law enforcement officers...

  19. Conventional forces and arms control: Technology and strategy in a changing world

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, J.F.; White, P.C.

    1990-06-01

    To address the implications of changes for future roles of conventional forces and to assess the technology implications of future strategies, force requirements, and conventional arms control agreements, the Center for National Security Studies in cooperation with the Defense Research and Applications Directorate of the Los Alamos National Laboratory held a conference on Conventional Forces and Arms Control: Technology and Strategy in a Changing World'' at Los Alamos from September 25--27, 1989. The distinguished participants from government, industry, and academia in the United States and Western Europe addressed such issues as: What are the implications of geopolitical and technological trends for international security and stability How will these global changes affect US and allied strategies and force structure, especially the requirements for conventional, nonnuclear forces What will be the role of and rationale for conventional forces in the context of current and prospective allied security requirements How can the West assure it will have the forces necessary for its security How will technological developments influence the structure of tomorrow's conventional forces What impacts will arms reductions have on future systems and force structures What are the prospects for the development and deployment in weapon systems of future conventional military technologies, in light of existing and potential political, economic, bureaucratic, and other impediments

  20. Military compensation in the Armenian Armed Forces: life cycle cost model for the Armenian Army

    OpenAIRE

    zurLippe, Jan-Hendrik C.

    2013-01-01

    Approved for public release; distribution is unlimited. The Armenian Armed Forces is moving from a conscript force to a volunteer force. They are based on a soviet-era military structure, but are attempting to adopt a Western-style of force structure, similar to the U.S. and U.K. A key element in this is the establishment of a professional NCO corps within the Armenian Army. As they seek to develop the senior enlisted ranks, as well as move to an all-volunteer force, they have identified t...

  1. Basic Radiobiology. Chapter 2

    International Nuclear Information System (INIS)

    Radiobiology is the study (both qualitative and quantitative) of the actions of ionizing radiations on living matter. Since radiation has the ability to cause changes in cells which may later cause them to become malignant, or bring about other detrimental functional changes in irradiated tissues and organs, consideration of the associated radiobiology is important in all diagnostic applications of radiation. Additionally, since radiation can lead directly to cell death, consideration of the radiobiological aspects of cell killing is essential in all types of radiation therapy

  2. The Use of Armed Force, Weapons of Mass Destruction and the UN

    Directory of Open Access Journals (Sweden)

    Hans Blix

    2006-06-01

    Full Text Available At the present time we do not see any risk of major powers using armed force against each other. The relations between the great powers are not exactly relaxed, but they are also not tense. All pursue the market economy of various shapes and shades as their economic model. All are bent on pragmatism. After the end of the Cold War European countries do not see Russia as a military threat and many states in Europe are reorienting their armed forces from defense of their own territory to use in international peacekeeping or peace-enforcing operations.

  3. Treating self-injury: water mist spray versus facial screening or forced arm exercise.

    OpenAIRE

    N.N. Singh; Watson, J. E.; Winton, A S

    1986-01-01

    In three experiments, the effect of water mist spray on self-injurious and collateral behaviors was compared with either facial screening or forced arm exercise. Water mist spray was as effective as facial screening in suppressing face-slapping in Experiment 1. However, it was not as effective as facial screening for self-injurious finger-licking in Experiment 2 or forced arm exercise for excessive ear-rubbing in Experiment 3. These results suggest that while water mist spray is effective, it...

  4. Arms for works protection force of nuclear power plant

    International Nuclear Information System (INIS)

    (1) Section 7 II, no. 5 of the Atomic Energy Act provides the legal basis for the imposition of an obligation attached to a licence granted under atomic energy law for the operation of a nuclear power station, to have the station protected by armed security personnel physical protection services. (2) Any judicial review of decisions taken by the regulatory authority with regard to the physical protection of the installation against acts of disturbance and other action taken by third parties, required within the meaning of section 7 II, no. 5 Atomic Energy Act, as well as instructions given within the purview of section 7 II no. 3 Atomic Energy Act, will have to be restricted to examining whether the decision taken is based on due and non-arbitrary investigation of conditions by the authority Federal Administrative Court decision of Janaury 19, 1989 - 7 C 31/87 (Mannheim). (orig.)

  5. A Comparison between Two Force-Position Controllers with Gravity Compensation Simulated on a Humanoid Arm

    OpenAIRE

    Giovanni Gerardo Muscolo; Kenji Hashimoto; Atsuo Takanishi; Paolo Dario

    2013-01-01

    The authors propose a comparison between two force-position controllers with gravity compensation simulated on the DEXTER bioinspired robotic arm. The two controllers are both constituted by an internal proportional-derivative (PD) closed-loop for the position control. The force control of the two systems is composed of an external proportional (P) closed-loop for one system (P system) and an external proportional-integrative (PI) closed-loop for the other system (PI system). The simulation t...

  6. Promoting Positive Emotional Health of Children of Transient Armed Forces Families

    Science.gov (United States)

    Eodanable, Miranda; Lauchlan, Fraser

    2012-01-01

    The focus of this research was to promote emotional health in a small primary school (n = 180), with a highly transient pupil population of armed forces children (Service children). Negative effects of pupil mobility have been found to relate to academic attainment (Dobson, Henthorne, & Lynas, 2000; Mott, 2002), but its effect on social and…

  7. Queen Margarethe II Wants You! Diversity in the Danish Armed Forces

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    with more diverse militaries, such as the United States, Great Britain, and Canada, include recognition of diversity as a societal imperative to sustain the legitimacy of the armed forces, the necessity of systematically collecting and reporting personnel data to guide policy, the necessity of patience...

  8. 76 FR 32224 - Migratory Birds; Take of Migratory Birds by the Armed Forces

    Science.gov (United States)

    2011-06-03

    ... authorizing the referenced incidental take in the Federal Register on February 28, 2007 (72 FR 8931). The... Fish and Wildlife Service Migratory Birds; Take of Migratory Birds by the Armed Forces AGENCY: Fish and... birds during approved military readiness activities without violating the Migratory Bird Treaty...

  9. Experimental Determination of Human Arm Force/Elbow Joint Angle Relation

    Czech Academy of Sciences Publication Activity Database

    Krejsa, Jiří; Zezula, M.; Věchet, Stanislav

    Prague : Institute of Thermomechanics AS CR, v. v. i., 2010 - (Zolotarev, I.), s. 79-80 ISBN 978-80-87012-26-0. [Engineering Mechanics 2010. Svratka (CZ), 10.05.2010-13.05.2010] Institutional research plan: CEZ:AV0Z20760514 Keywords : intelligent orthosis * human arm force measurement Subject RIV: JB - Sensors, Measurment, Regulation http://www.engmech.cz/

  10. Intuitive Decisionmaking: Tacit Knowing in Action by U.S. Armed Forces Officers in 2011

    Science.gov (United States)

    Moilanen, Jon H.

    2012-01-01

    This qualitative inquiry was a naturalistic exploration of participants' perception or understanding of their intuitive decisionmaking processes. A bounded case study explored how a purposeful sampling of U.S. Armed Forces officers--primarily U.S. Army officers--perceived or understood intuitive decisionmaking in the context of their…

  11. 33 CFR 334.740 - Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area. 334.740 Section 334.740 Navigation and Navigable... REGULATIONS § 334.740 Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area....

  12. Kyrgyzstan’s Fragmented Police and Armed Forces

    Directory of Open Access Journals (Sweden)

    Erica Marat

    2011-03-01

    Full Text Available This article is a first attempt to analyze the underlying reasons behind the unprofessional behavior of the Kyrgyz military and police during ethnic conflict in Osh on June 10-14, 2010. It argues that the higher military leadership in Bishkek shares a common distrust of the Tashkent regime and overall uncertainly about power sharing two months after regime change, while lower level personnel may have provoked the Uzbek minority, because of their nationalist feelings (the majority of police and army personnel are ethnic Kyrgyz and overall frustration with the fragmented political leadership. The situation was further exacerbated by the lack of political control over the security forces and their lack of adequate training to deal with civic unrest.

  13. 75 FR 4051 - Defense Health Board; DoD Task Force on the Prevention of Suicide by Members of the Armed Forces...

    Science.gov (United States)

    2010-01-26

    ... of the Secretary Defense Health Board; DoD Task Force on the Prevention of Suicide by Members of the...)(2) of Public Law, the DoD Task Force on the Prevention of Suicide by Members of the Armed Forces (hereafter, Task Force) will meet on February 11, 2010, to gather information pertaining to suicide...

  14. Rehabilitation of a Human Arm Supported by a Robotic Manipulator: A Position/Force Cooperative Control

    Directory of Open Access Journals (Sweden)

    Haifa Mehdi

    2010-01-01

    Full Text Available Problem statement: The assistance of person with limited ability of arm movement is necessary for rehabilitation reasons. This aid is required not only to cover the human performances of the arm in motion and force but also to have a strictly stable dynamics. In this study, we proposed a cooperative system between a disabled arm and a robotic manipulator to reach such objectives. Desired positions and contact forces were imposed by the disabled human whereas appropriate torques were applied by the manipulator to follow human intension. Approach: Various control strategies were proposed during recent years to solve position/force control problem. The impedance control concept was used in this study. A relationship between the dynamics of the robot and its energy was developed to derive stability conditions of the robotic system at the constrained motion phase using a suitable Lyapunov approach. Results: New sufficient conditions of asymptotic stability were developed. To prove the efficiency of the proposed approach, a prototype of a human arm coupled to cooperative constrained robotic manipulator was used. The simulation results showed the stability and the performances of the proposed approach. Conclusion: Results showed the possibility of their use in a real context of rehabilitation of injured and disabled people.

  15. A Comparison between Two Force-Position Controllers with Gravity Compensation Simulated on a Humanoid Arm

    Directory of Open Access Journals (Sweden)

    Giovanni Gerardo Muscolo

    2013-01-01

    Full Text Available The authors propose a comparison between two force-position controllers with gravity compensation simulated on the DEXTER bioinspired robotic arm. The two controllers are both constituted by an internal proportional-derivative (PD closed-loop for the position control. The force control of the two systems is composed of an external proportional (P closed-loop for one system (P system and an external proportional-integrative (PI closed-loop for the other system (PI system. The simulation tests performed with the two systems on a planar representation of the DEXTER, an eight-DOF bioinspired arm, showed that by varying the stiffness of the environment, with a correct setting of parameters, both systems ensure the achievement of the desired force regime and with great precision the desired position. The two controllers do not have large differences in performance when interacting with a lower stiffness environment. In case of an environment with greater rigidity, the PI system is more stable. The subsequent implementation of these control systems on the DEXTER robotic bioinspired arm gives guidance on the design and control optimisation of the arms of the humanoid robot named SABIAN.

  16. Radiobiological Research in JINR

    CERN Document Server

    Krasavin, E A

    2000-01-01

    The results of long-term radiobiological and radiation-genetical research in DRRR (Division of Radiobiology) are summarized. The different radiation-induced effects in bacteria, yeasts, mammalian and human cells after irradiation by gamma-rays and heavy charged particles are considered. The important role of DNA repair processes in biological effectiveness of different types of radiation were shown. The data on mutagenic action of such kinds of radiation on pro- and eukaryotic cells were analyzed. On the basis of our data the hypersensitivity of human and mammalian chromosomes after low doses of gamma-rays (10-20 sGy) was revealed. The radiobiological effect of ^{211}At - methylene blue complex on human melanoma cells was studied. The extremely high effectiveness of this complex on melanoma cells was shown.

  17. OPTIMIZATION OF FINANCIAL PERSONNEL NUMBER IN ARMED FORCES OF THE REPUBLIC OF BELARUS

    Directory of Open Access Journals (Sweden)

    A. V. Bolshakova

    2014-01-01

    Full Text Available The paper considers a problem pertaining to reduction of the Armed Forces of the Republic of Belarus and necessity to carry out economically reasonable reforms optimizing strength of financial personnel with the purpose to decrease its number but without undermining financial and operational activities of the Armed Forces as a whole. It has been proposed to optimize strength of financial personnel in the Armed Forces while executing organizational staff transformations such as introduction of a centralized accounting system for service personnel by an example of the Ministry of Defense of the Russian Federation.Normative for financial personnel strength of the supposed unified financial centre which is involved in accounting recordings on salary and other payments has been calculated on the basis of inter-branch standards. While taking as an example a conventional organization “B” with staff strength which is equal to the strength of the Armed Forces of the Republic of Belarus the possible efficiency in introduction of the centralized accounting system for service personnel has been determined in the paper. According to represented calculations reduction of financial personnel dealing with accounting recordings on salary and other payments in the whole organization “B” can constitute up to 60 persons with more than 200 branches which are carrying out independent payment accounting for personnel concerned.Dependence of strength normative on number of financial bodies, percentage of personnel receiving payments through a unified financial centre and concentration of financial and economic document circulation has been determined in the paper. It has been pointed out that it is not sufficient to determine quantitative indices in order to ensure an objective reflection of the efficiency of possible introduction of the centralized accounting system for service personnel in the Armed Forces. In order to obtain complete information it is

  18. Development of the combat sleeping bag system of the Latvian National Armed Forces

    OpenAIRE

    Sitvjenkins, Igors; Kuklane, Kalev; Vilumsone, Ausma; Abele, Iveta

    2014-01-01

    Latvian National Armed forces (LNAF) in cooperation with Lund University, Sweden and Riga Technical University, Latvia has developed the combat sleeping bag system (CSBS) of the LNAF under the Soldier System platform (SSP) 2009 – 2013 modernization program. Protection from the cold and thermal infrared surveillance during the low level metabolic heat rate of sleeping (40 W/m2) is the key aspect of the survivability of the soldier in combat and training operation to maintain task fulfilled....

  19. The Revolutionary Armed Forces of Colombia (FARC) and the Development of Narco-Submarines

    OpenAIRE

    Michelle Jacome Jaramillo

    2016-01-01

    The Revolutionary Armed Forces of Colombia (FARC) have been one of the world's most consistently formidable violent non-state actors over the last forty years. Unsurprisingly, the group has provided one of the most compelling and concerning examples of the level of technical sophistication attainable by sub-state organizations. Over the last two decades the group has carried out an iterative and innovative process that, in reaction to improved detection capabilities, has brought them from dep...

  20. Project management in major systems acquisition for the Polish Armed Forces

    OpenAIRE

    Chyla, Wojciech L.

    2003-01-01

    This project investigates the potential role of project management policy in major systems acquisition for the Polish Armed Forces (PAF). It includes a short overview of program management in the United States Department of Defense (DoD); analysis of present procedures in the PAF; a cost and benefit discussion of implementing the policy in Poland; and finally, a discussion of possible solutions and implementation plans. The PAF have undergone major transformation since the fall of the Berlin'...

  1. AN EMPIRICAL SURVEY ON BASIC MILITARY TRAINING IN SLOVENIAN ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Maja GARB

    2014-04-01

    Full Text Available Before employment in the Slovenian Armed Forces, all candidates have to finish basic military training. The empirical survey, done in 2011 on a group of military candidates in a Slovenian Training Center, checked the motivation, level of skills and education, attitudes of leaders, military identity, prestige and social support of these candidates. The results confirmed the skills’ and fighters’ orientation of Slovenian soldiers, but surprised with the paleomodern motivators for military job.

  2. German Soldier and German Unity: Political Foundations of the German Armed Forces

    OpenAIRE

    Abenheim, Donald

    1991-01-01

    The unification of Germany has transformed the political-military landscape of central Europe. Not the least of the issues raised by the union of the Federal Republic and the German Democratic Republic is the fate of the professional soldier in a united Germany. The present study analyzes the concept of military professionalism in the setting of the two former German states, placing emphasis on the political-ethical foundations of the West German armed forces and the political mechanisms of t...

  3. The impact of military identity on performance in the Norwegian Armed Forces

    OpenAIRE

    Johansen, Rino Bandlitz

    2013-01-01

    From a Norwegian point of view, doctrinaire guidance now set the premises for new perspectives related to the military ethos and identity. The exodus of idealism, a military identity based on traditional values as altruism, patriotism and nationalism, has opened up for professionalism as a preferred and necessary military identity in the Norwegian armed forces. Based on this paradigmatic change, it follows that if professionalism could be reliably defined and measured, it might...

  4. Sensor prototype to evaluate the contact force in measuring with coordinate measuring arms

    OpenAIRE

    Eduardo Cuesta; Alejandro Telenti; Hector Patiño; Daniel González-Madruga; Susana Martínez-Pellitero

    2015-01-01

    This paper describes the design, development and evaluation tests of an integrated force sensor prototype for portable Coordinate Measuring Arms (CMAs or AACMMs). The development is based on the use of strain gauges located on the surface of the CMAs’ hard probe. The strain gauges as well as their cables and connectors have been protected with a custom case, made by Additive Manufacturing techniques (Polyjet 3D). The same method has been selected to manufacture an ergonomic handle that includ...

  5. A Feminine Touch : Gender and Civil-Military Relations in the Chilean Armed Forces

    OpenAIRE

    Gundersrud, Synne Høie

    2015-01-01

    This analysis explores the extent to which gender equality exists within the Chilean military institutions. A clear political and legal space has been created for equality to grow in Chile, and many advances in Chilean politics demonstrate progress in terms of expanding the gender equality agenda in Chilean society. However, my analysis indicates that traditional and discriminatory ideas of gender, dominating the culture of the Chilean Armed Forces, are limiting the social process of integrat...

  6. Engagement of the Slovak Armed Forces in Future Crisis Management Operations

    OpenAIRE

    Peter PINDJÁK

    2014-01-01

    During the past two decades, the Armed Forces of the Slovak Republic (AF SR) have participated in more than thirty operations under major international organizations and coalitions. Despite the political interest to sustain active engagement of the AF SR in international crisis management operations, the declining level of capabilities coupled with the urgent need to modernize most of the military equipment compels the Slovak Ministry of Defense to commence a complex optimization process. Eve...

  7. A model of contract administration for the Armed Forces of the Philippines (AFP) modernization program

    OpenAIRE

    Taccad, Caesar C.

    1999-01-01

    The purpose of this thesis is to determine and develop the appropriate system for the implementation and administration of contracts formulated under the Armed Forces of the Philippines (AFP) Modernization Program. In 1995, the Philippine Congress mandated the modernization of the AFP through a is-year program under Republic Act (RA) 7898. Subsequently, the Department of National Defense (DND) issued Circular No. 29 to implement the Act. The Circular provided adequate guidance for the conduct...

  8. Research in Radiobiology

    International Nuclear Information System (INIS)

    This document contains the tables of contents for the reports published by the University of Utah Radiobiology Laboratory from 1953--1987. Also included is a keyword index for the reports, and references for all books, book and symposia chapters and journal article published by Laboratory staff between 1950 and 1988

  9. With the Radiobiology Group

    CERN Multimedia

    1980-01-01

    The Radiobiology Group carries out experiments to study the effect of radiation on living cells. The photo shows the apparatus for growing broad beans which have been irradiated by 250 GeV protons. The roots are immersed in a tank of running water (CERN Weekly Bulletin 26 January 1981 and Annual Report 1980 p. 160). Karen Panman, Marilena Streit-Bianchi, Roger Paris.

  10. Hereditary cerebellar ataxia progressively impairs force adaptation during goal-directed arm movements.

    Science.gov (United States)

    Maschke, Matthias; Gomez, Christopher M; Ebner, Timothy J; Konczak, Jürgen

    2004-01-01

    We investigated how humans with hereditary cerebellar degeneration [spinocerebellar ataxia (SCA) type 6 and 8, n = 9] and age- and sex-matched healthy controls (n = 9) adapted goal-directed arm movements to an unknown external force field. We tested whether learning could be generalized to untrained regions in the workspace, an aspect central to the idea of an internal model, and if any learning could be retained. After removal of the force field, SCA patients showed little or no learning-related aftereffects indicating that repeated force-field exposure never led to successful force compensation. In contrast, healthy control subjects quickly adapted their movements to the new force field. The difference in force adaptation was significant for movements to targets that required both the shoulder and elbow joint (P < 0.001). Moreover, the generalization of learned movements to targets outside the learned workspace was prevented by the cerebellar degeneration (P < 0.01). Retention of force adaptation was significantly lower in SCA patients (P = 0.003). The severity of ataxia in SCA patients correlated negatively with the extent of learning (r = -0.84, P = 0.004). Our findings imply that progressive loss of cerebellar function gradually impairs force adaptation. The failure to generalize learning suggests that cerebellar degeneration prevents the formation of an internal representation of the limb dynamics. PMID:13679403

  11. Are the Armed Forces Understood and Supported by the Public?:A View from the United Kingdom

    OpenAIRE

    Hines, Lindsey Anne; Gribble, Rachael; Wessely, Simon Charles; Dandeker, Christopher; Fear, Nicola Townsend

    2015-01-01

    Despite the importance of public opinion in supporting the military and their missions, little is known about how the UK public perceive their Armed Forces. This article reviews and evaluates available research and opinion poll data of public attitudes toward the UK military and situates the evidence within the civil–military gap literature. Current evidence suggests public regard for the UK Armed Forces is high despite low levels of support for the Iraq and Afghanistan missions. Public under...

  12. Forces and moments generated by the human arm: Variability and control

    Science.gov (United States)

    Xu, Y; Terekhov, AV; Latash, ML; Zatsiorsky, VM

    2012-01-01

    This is an exploratory study of the accurate endpoint force vector production by the human arm in isometric conditions. We formulated three common-sense hypotheses and falsified them in the experiment. The subjects (n=10) exerted static forces on the handle in eight directions in a horizontal plane for 25 seconds. The forces were of 4 magnitude levels (10 %, 20%, 30% and 40% of individual MVC). The torsion moment on the handle (grasp moment) was not specified in the instruction. The two force components and the grasp moment were recorded, and the shoulder, elbow, and wrist joint torques were computed. The following main facts were observed: (a) While the grasp moment was not prescribed by the instruction, it was always produced. The moment magnitude and direction depended on the instructed force magnitude and direction. (b) The within-trial angular variability of the exerted force vector (angular precision) did not depend on the target force magnitude (a small negative correlation was observed). (c) Across the target force directions, the variability of the exerted force magnitude and directional variability exhibited opposite trends: In the directions where the variability of force magnitude was maximal, the directional variability was minimal and vice versa. (d) The time profiles of joint torques in the trials were always positively correlated, even for the force directions where flexion torque was produced at one joint and extension torque was produced at the other joint. (e) The correlations between the grasp moment and the wrist torque were negative across the tasks and positive within the individual trials. (f) In static serial kinematic chains, the pattern of the joint torques distribution could not be explained by an optimization cost function additive with respect to the torques. Plans for several future experiments have been suggested. PMID:23080084

  13. Between history, amnesia and selective memory: The South African armed forces, a century’s perspective

    Directory of Open Access Journals (Sweden)

    Ian Van der Waag

    2013-02-01

    Full Text Available 2012 has a double significance for this year sees the centenary of the founding of the African National Congress (8 January and of the creation of the Union Defence Forces (1 July, two organisations that have for much of the twentieth century shared a contested history. Yet, in a remarkable bouleversement, South Africa has come through this difficult past and, over the past two decades, a new South African society has been recreated following an interesting period of adjustment following the end of the Cold War and the growth of democracy in the developing world. These changes have necessarily affected her armed forces and the roles defined for them. Some commentators, particularly in the years immediately following 1994, asserted that military power had lost all of its vaunted, Cold-War importance in a new postmodern environment. Others still, recognising future challenges, argued that South Africa, beset with far-reaching socio-economic crises, could no longer afford the burden of military forces. Most scholars agree now that these perspectives were short-sighted and that, while the risk of major conflict has receded, the events of 9/11, and its consequences, demonstrate that the continental and international landscapes are less certain, less stable and less predictable, than that for which many had hoped. Clearly, South African interests are intertwined inextricably in regional and global affairs and if she is to protect these interests and ensure her security, she must maintain credible military force capable of meeting an array of contingencies. It was with this in mind that the strategic arms deal, since the subject of much debate, was passed by parliament:[i] the promise of a full technological transformation, to accompany the human transformation, offered. [i] J Sylvester & A Seegers. “South Africa’s Strategic Arms Package: A Critical Analysis”. Scientia Militaria 36/1. 2008. 52-77.

  14. Department of Radiobiology - foreword

    International Nuclear Information System (INIS)

    The research program of the Department of Radiobiology of the Niewodniczanski Institute of Nuclear Physics is performed by two laboratories: 1/Laboratory of Neutron Therapy and Applied in Radiobiology Therapy and Agriculture. 2/ Laboratory of Radiation and Environmental Mutagenesis. The aim of the first mentioned Laboratory is to determine the Relative Biological Effectiveness (RBE) of fast 5.6 MeV neutrons with regard to regime of fractionation. Our goal is to reduce the number of fraction of neutron therapy what makes possible increasing the total dose. The second mentioned Laboratory engages in research on the mutagenesis in rape-seed in vitro regeneration of dihaploids and pollen grains. The object is to find how much fast neutrons, X and γ-rays irradiations stimulate the dihaploide production and to determine their reaction in flower buds microspores and anther cultures. (author)

  15. [The organizational bases for the building of a modern medical support system for the Armed Forces].

    Science.gov (United States)

    Chizh, I M

    1996-01-01

    In the article the problems concerning characteristic features of the local wars and armed conflicts, organization bases of construction of The Army and Fleet medical support modern system are discussed. The organization of personnel medical security is considered depending on the duration, intensity and spatial scope of military conflict, peculiarities of group (forces) application and ways of military actions conduction. The distribution of federal troops sanitary losses during the war in Chechenskaya Republic is shown depending on the type, localization and degree of injuries gravity as well as volume of the wounded and invalids evacuation by air transport and work of military medical institutions. The following principles of construction of the Armed Forces medical support system are formulated: The system must be in compliance with troops goals, structure, strategy and tactics, its specificity; development of medical security forms and methods, their historicism; interdependency, completeness and integrity of the system's elements; territorial aspects of its construction and management optimization. Considering character of the goals being laid on the Mobile Forces the paramount importance is attached to the level of readiness of medical service and its formations and units to act in crisis situations. PMID:8659162

  16. Wartorn Britain: How do former British armed forces personnel locate stateviolence within their personal lived experience?

    OpenAIRE

    Bluett, Michael Brendan

    2014-01-01

    In my thesis film and text I explore how former British armed forces personnel locate state violence within their personal lived experience 2013. The film takes its title from the general condition of a nation that is constantly at war, producing and exporting state violence. In the film, this collective condition is explored through a portrait of one veteran of the recent Iraq war, now returned to his home in Blackpool. We see how he locates past experiences of violence and follow him throug...

  17. Motor adaptation to Coriolis force perturbations of reaching movements: endpoint but not trajectory adaptation transfers to the nonexposed arm

    Science.gov (United States)

    Dizio, P.; Lackner, J. R.

    1995-01-01

    1. Reaching movements made in a rotating room generate Coriolis forces that are directly proportional to the cross product of the room's angular velocity and the arm's linear velocity. Such Coriolis forces are inertial forces not involving mechanical contact with the arm. 2. We measured the trajectories of arm movements made in darkness to a visual target that was extinguished at the onset of each reach. Prerotation subjects pointed with both the right and left arms in alternating sets of eight movements. During rotation at 10 rpm, the subjects reached only with the right arm. Postrotation, the subjects pointed with the left and right arms, starting with the left, in alternating sets of eight movements. 3. The initial perrotary reaching movements of the right arm were highly deviated both in movement path and endpoint relative to the prerotation reaches of the right arm. With additional movements, subjects rapidly regained straight movement paths and accurate endpoints despite the absence of visual or tactile feedback about reaching accuracy. The initial postrotation reaches of the left arm followed straight paths to the wrong endpoint. The initial postrotation reaches of the right arm had paths with mirror image curvature to the initial perrotation reaches of the right arm but went to the correct endpoint. 4. These observations are inconsistent with current equilibrium point models of movement control. Such theories predict accurate reaches under our experimental conditions. Our observations further show independent implementation of movement and posture, as evidenced by transfer of endpoint adaptation to the nonexposed arm without transfer of path adaptation. Endpoint control may occur at a relatively central stage that represents general constraints such as gravitoinertial force background or egocentric direction relative to both arms, and control of path may occur at a more peripheral stage that represents moments of inertia and muscle dynamics unique to each

  18. Armes

    OpenAIRE

    Camps, G.; Chenorkian, R.; Lhote, H.

    2013-01-01

    Préhistoire (G. Camps) Les armes des Paléoberbères de la Préhistoire ne présentent guère d’originalité mais à la documentation archéologique provenant de fouilles s’ajoute, en Afrique du Nord et au Sahara, une documentation iconographique d’une grande richesse que ne possèdent pas les autres pays riverains du bassin occidental de la Méditerranée. Durant les temps paléolithiques, les hommes qui occupèrent le Maghreb et le Sahara utilisèrent, en plus des outils et armes connus ailleurs ; biface...

  19. Sensor Prototype to Evaluate the Contact Force in Measuring with Coordinate Measuring Arms

    Directory of Open Access Journals (Sweden)

    Eduardo Cuesta

    2015-06-01

    Full Text Available This paper describes the design, development and evaluation tests of an integrated force sensor prototype for portable Coordinate Measuring Arms (CMAs or AACMMs. The development is based on the use of strain gauges located on the surface of the CMAs’ hard probe. The strain gauges as well as their cables and connectors have been protected with a custom case, made by Additive Manufacturing techniques (Polyjet 3D. The same method has been selected to manufacture an ergonomic handle that includes trigger mechanics and the electronic components required for synchronizing the trigger signal when probing occurs. The paper also describes the monitoring software that reads the signals in real time, the calibration procedure of the prototype and the validation tests oriented towards increasing knowledge of the forces employed in manual probing. Several experiments read and record the force in real time comparing different ways of probing (discontinuous and continuous contact and measuring different types of geometric features, from single planes to exterior cylinders, cones, or spheres, through interior features. The probing force is separated into two components allowing the influence of these strategies in probe deformation to be known. The final goal of this research is to improve the probing technique, for example by using an operator training programme, allowing extra-force peaks and bad contacts to be minimized or just to avoid bad measurements.

  20. NOVEL 6-DOF WEARABLE EXOSKELETON ARM WITH PNEUMATIC FORCE-FEEDBACK FOR BILATERAL TELEOPERATION

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiafan; FU Hailun; DONG Yiming; ZHANG Yu; YANG Canjun; CHEN Ying

    2008-01-01

    A particular emphasis is put on a novel wearable exoskeleton arm, ZJUESA, with 6 degrees of freedom, which is used for the robot teleoperation with the force-feedback in the unknown environment. In this external structure mechanism, the 3-revolution-prismatic-spherical (3RPS) parallel mechanism is devised from the concept of the human upper-limb anatomy and applied for the shoulder 3-DOF joint. Meanwhile, the orthogonal experiment design method is introduced for its optimal design. Aiming at enhancing the performance of teleoperation, the force feedback is employed by the pneumatic system on ZJUESA to produce the vivid feeling in addition to the soft control interface. Due to the compressibility and nonlinearity of the pneumatic force feedback system, a novel hybrid fuzzy controller for the precise force control is proposed and realized based on the Mega8 microcontroller units as the units of the distributed control system on ZJUESA. With the results of several experiments for master-slave control with force feedback, the feasibility of ZJUESA system and the effect of its hybrid fuzzy controller are verified.

  1. Decree No. 83/7467 of 24 November 1983 on visits of foreign armed forces vessels in Turkish waters

    International Nuclear Information System (INIS)

    This Decree (No. 83/7467) lays down the principles and procedures for the visits of foreign armed forces vessels in Turkish harbours and inland waterways and came into force on 15 December 1983. This new Decree supersedes a similar Decree of 27 December 1978. (NEA)

  2. Influence of Reynolds number and forcing type in a turbulent von K\\'arm\\'an flow

    CERN Document Server

    Saint-Michel, Brice; Marié, Louis; Ravelet, Florent; Daviaud, François

    2014-01-01

    We present a detailed study of of a global bifurcation occuring in a turbulent von K\\'arm\\'an swirling flow. In this system, the statistically steady states progressively display hysteretic behaviour when the Reynolds number is increased above the transition to turbulence. We examine in detail this hysteresis using asymmetric forcing conditions --- rotating the impellers at different speeds. For very high Reynolds numbers, we study the sensitivity of the hysteresis cycle --- using complementary Particle Image Velocimetry (PIV) and global mechanical measurements --- to the forcing nature, imposing either the torque or the speed of the impellers. New mean states, displaying multiple quasi-steady states and negative differential responses, are experimentally observed in torque control. A simple analogy with electrical circuits is performed to understand the link between multi-stability and negative responses. The system is compared to other, similar "bulk" systems, to understand some relevant ingredients of nega...

  3. Etiology and pattern of maxillofacial injuries in the armed forces of pakistan

    International Nuclear Information System (INIS)

    To determine the etiology and pattern of maxillofacial injuries in the Armed Forces of Pakistan in terms of anatomical distribution of injuries. Three hundred consecutive patients of Armed Forces of Pakistan with maxillofacial injuries reporting to AFID and admitted to the hospital or treated as out-patients in the oral surgery clinic, were included in this study. Isolated nasal bone and frontal sinus fractures were excluded from the study. Anatomical distribution, frequency and etiology of fractures, rank at job and occupational as well as personal hobbies were recorded. Descriptive analyses were used to determine mean, standard deviation, percentage and range values. The most frequent bone fractured was the mandible, which accounted for 159 cases (53%). The zygomatic complex was fractured in 51 cases (17%), the maxilla in 12 cases (4 %), and the alveolar process in 21 cases (7%). The most common cause was road traffic accident (168 cases; 56%), followed by accidental fall (69 cases; 23%), gunshot injuries (27 cases; 9%), sports related injuries (15 cases; 5%), and injury associated with a fight (12 cases; 4%); there were only 9 cases of animals related injuries (3%). In this series, mandible was the most commonly fractured facial bone, while road traffic accident was the most common etiological factor. Results could be influenced by the personal and working environment. (author)

  4. Adaptive gravity and joint stiffness compensation methods for force-controlled arm supports

    NARCIS (Netherlands)

    Lobo-Prat, Joan; Keemink, Arvid Q.L.; Koopman, Bart F.J.M.; Stienen, Arno H.A.; Veltink, Peter H.

    2015-01-01

    People with muscular weakness can benefit from arm supports that compensate the weight of their arms. Due to the disuse of the arms, passive joint stiffness increases and providing only gravity compensation becomes insufficient to support the arm function. Hence, joint stiffness compensation is also

  5. IMPLEMENTATION OF RISK MANAGEMENT IN THE ARMED FORCES OF THE SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Lubomír BELAN

    2015-10-01

    Full Text Available The risk management process represents the systematic application of management policies, procedures and experience focused on the activities of communication, consultation on how to create the appropriate context and on the identification, analysis, evaluation, handling, monitoring, and review of risks. Its content is represented by general principles, communication and counseling, creating links, risk assessment, monitoring and review of risks, handling and record of the process of risk management. In terms of The Armed Forces of the SR (OS SR, this issue is an important part of management in terms of proper functionality of the components, services, and facilities (qualifications. It is certainly the difficulty and danger incurred by the processes carried out in these organizational structures (e.g. shooting, weapon handling and training, etc. that provides a clear answer on what is necessary to do for a successful implementation of risk management issues.

  6. [Modern problems and main ways of imorovement of disinfecting art in Armed Forces].

    Science.gov (United States)

    Ivanov, A A; Musaev, A A; Komissarov, N V; Seleznev, A B; Loshakov, O V

    2016-02-01

    The article states the reasons defining the high relevance and significance of disinfection measures in modern conditions, reports general and specific problems of ensuring disinfection during medical service day-to-day activities. The directions of development of chemical and technical disinfectants and methods for'their use on different objects and under various climatic conditions are determined. It was shown that the crucial condition for implementation of theoretical and practical ways of improving disinfection affairs is a comprehensive approach based on concerted efforts of all authorities of Russian Armed Forces Medical Services, research and sanitary-epidemiological institutions, as well as relevant chars of the Military Medical Academy in close cooperation with representatives of domestic industry. PMID:27263206

  7. A comparative study of the active force control schemes applied to robot arm

    International Nuclear Information System (INIS)

    In this paper, a comparative study of three different types of active force control (AFC) schemes applied to a robotic arm is described. The study particularly focuses on the techniques to compute the estimated inertia matrix (ΙΝ) of a robotic manipulator necessary for the execution of the AFC strategy since the computation of (ΙΝ) is the common central theme to all AFC-based schemes. The first of the three AFC schemes is based on the conventional method of obtaining (ΙΝ), the second uses artificial neural network while the third incorporates an iterative learning algorithm. The study also discusses the characteristics of the (ΙΝ) curves obtained, the trajectory track performance of the schemes and the effects of the modelled disturbances. The robustness of all the AFC schemes are also ascertained in the study. (Author)

  8. Radiation Protection Research: Radiobiology

    International Nuclear Information System (INIS)

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality in nuclear workers in Belgium; to document the feasibility of retrospective cohort studies in Belgium; (2) to participate in the IARC study; (3) to elucidate the molecular basis of the effects of ionising radiation in the mammalian embryo during the early phases of its development; (4) to assess the genetic risk of maternal exposure to ionizing radiation; (5) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 1999 are reported

  9. Non-extensive radiobiology

    Science.gov (United States)

    Sotolongo-Grau, O.; Rodriguez-Perez, D.; Antoranz, J. C.; Sotolongo-Costa, O.

    2011-03-01

    The expression of survival factors for radiation damaged cells is based on probabilistic assumptions and experimentally fitted for each tumor, radiation and conditions. Here we show how the simplest of these radiobiological models can be derived from the maximum entropy principle of the classical Boltzmann-Gibbs expression. We extend this derivation using the Tsallis entropy and a cutoff hypothesis, motivated by clinical observations. A generalization of the exponential, the logarithm and the product to a non-extensive framework, provides a simple formula for the survival fraction corresponding to the application of several radiation doses on a living tissue. The obtained expression shows a remarkable agreement with the experimental data found in the literature, also providing a new interpretation of some of the parameters introduced anew. It is also shown how the presented formalism may have direct application in radiotherapy treatment optimization through the definition of the potential effect difference, simply calculated between the tumour and the surrounding tissue.

  10. Radiation Protection Research: Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C

    2000-07-01

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality in nuclear workers in Belgium; to document the feasibility of retrospective cohort studies in Belgium; (2) to participate in the IARC study; (3) to elucidate the molecular basis of the effects of ionising radiation in the mammalian embryo during the early phases of its development; (4) to assess the genetic risk of maternal exposure to ionizing radiation; (5) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 1999 are reported.

  11. CHARACTERISTICS OF PRIMARY HEALTH CARE UTILIZATION OF MILITARY STAFF AND THEIR FAMILIES IN TURKISH ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Ozlem Ozkan

    Full Text Available Aim: The study was conducted to define characteristics of primary health care utilization of military staff and their families in Turkish Army Forces. Material-Method: A cross-sectional survey method was used. This study has carried out in 10 primary health care institutions in Ankara Military Zone which is tied to Turkish Armed Forces Land Forces Commandership in 1998. The data have been obtained from the application reasons of Turkish Armed Forces’ (TAF staff members and their families to main medical units and the results got after they have applied to those units and the physician’s intervention that have been written down on a form prepared by the researcher for a period of three months (January –March 1998. The data got from practices have been assessed by percentage Results:TAF’sstaff members commissioned in the detachment (4.0 and their families in dispensaries (8.7 have major application rate. While sergeants/corporals-privates in the detachment infirmary, and TSK staff members and their families in dispensaries have mostly applied to primary health care units for complaints (68.5%, 76.9%, 72.8%, the staff members working at the quatrain infirmary and their families have mostly applied to main medical units for the purpose of prescribing a medicine (59.8%, 90%. The most frequent diseases seen in military staff and their families in TAF are; diagnosed acute respiratory system infections, ankilosis acquired bone and muscle disorders, gastritis-duedonititis-ulcer, influenza, enteritis and diseases connected with diarrhoea, tonsillitis, parazitis-other infection diseases and bronchitis. Conclusion suggestions: These diseases are acute, preventable, high contagious diseases and the problems that occur related to these diseases could be eliminated within full-equipped primary health care services. Moreover, among the proposals of the research are the appointment of registered nurses to units health care to act as a public health nurses

  12. A numerical investigation of flow around octopus-like arms: near-wake vortex patterns and force development.

    Science.gov (United States)

    Kazakidi, A; Vavourakis, V; Tsakiris, D P; Ekaterinaris, J A

    2015-01-01

    The fluid dynamics of cephalopods has so far received little attention in the literature, due to their complexity in structure and locomotion. The flow around octopuses, in particular, can be complicated due to their agile and dexterous arms, which frequently display some of the most diverse mechanisms of motion. The study of this flow amounts to a specific instance of the hydrodynamics problem for rough tapered cylinder geometries. The outstanding manipulative and locomotor skills of octopuses could inspire the development of advanced robotic arms, able to operate in fluid environments. Our primary aim was to study the hydrodynamic characteristics of such bio-inspired robotic models and to derive the hydrodynamic force coefficients as a concise description of the vortical flow effects. Utilizing computational fluid dynamic methods, the coefficients were computed on realistic morphologies of octopus-like arm models undergoing prescribed solid-body movements; such motions occur in nature for short durations in time, e.g. during reaching movements and exploratory behaviors. Numerical simulations were performed on translating, impulsively rotating, and maneuvering arms, around which the flow field structures were investigated. The results reveal in detail the generation of complex vortical flow structures around the moving arms. Hydrodynamic forces acting on a translating arm depend on the angle of incidence; forces generated during impulsive rotations of the arms are independent of their exact morphology and the angle of rotation; periodic motions based on a slow recovery and a fast power stroke are able to produce considerable propulsive thrust while harmonic motions are not. Parts of these results have been employed in bio-inspired models of underwater robotic mechanisms. This investigation may further assist elucidating the hydrodynamics underlying aspects of octopus locomotion and exploratory behaviors. PMID:24730546

  13. A DIVERSE SOCIETY, A REPRESENTATIVE MILITARY? THE COMPLEXITY OF MANAGING DIVERSITY IN THE SOUTH AFRICAN ARMED FORCES

    OpenAIRE

    Lindy Heinecken

    2011-01-01

    After providing a brief background as to why issues of diversity managementwithin armed forces have become important internationally, this article outlines thediversity challenges facing the South African National Defence Force (SANDF).The first part of the article describes how the racial, language/ethnic and genderprofile of the SANDF has changed since 1994 and the tensions this has evoked. Thesecond part provides a brief conceptual framework against which diversitymanagement in the SANDF c...

  14. On the improvement of the control force readiness of students engaged arm sport

    Directory of Open Access Journals (Sweden)

    Voronkov A.V.

    2014-03-01

    Full Text Available Purpose: to identify the most informative tests and test exercises to assess force readiness athletes. Material : the study involved 23 students of mass sports categories. Ascertaining experiment involved testing athletes force readiness, analysis of their competitive activity and determination of strength and reliability of correlation tests with the results of the competition. There were 19 trials and two anthropometric measurements. Results : it was found that traditional tests to determine the strength abilities athletes enough authentic. A significant positive correlation with the results of competitive activity indicators carpal dynamometry (in two different weight classes, and on both hands in the categories of more than 85 kg. And pull-ups on the maximum number of times. A high degree of correlation between the results of competitive activity and holding a dumbbell on a special bench capture below. This exercise is effective for assessing the level of preparedness of special strength in the weight category up to 80 kg and 85 kg. Conclusions : the most informative tests and benchmarks to determine the exercise of power readiness 1-2 athletes in sports categories arm sport.

  15. 32 CFR 705.33 - Participation by Armed Forces bands, choral groups, and troops in the public domain.

    Science.gov (United States)

    2010-07-01

    ... limited to patriotic programs as opposed to pure entertainment and will not duplicate a performance within... colors, or a performance of military or patriotic music by a military band, drum and bugle corps or... musicians' union must be obtained by the sponsor and attached to his request. (c) Armed Forces musical...

  16. Radiobiology and Epidemiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C; Holmstock, L

    2001-04-01

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality in nuclear workers in Belgium and to co-ordinate the Belgian contribution to the 'International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry'; (2) to elucidate the molecular basis of individual susceptibility to ionizing radiation in mammalian embryo during the early phases of its development; (3) to assess the genetic risk of maternal exposure to ionizing radiation; (4) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (5) to monitor the early variations of gene expression induced by ionising radiation and cytokines; (6) to evaluate the use of cytokines and natural substances for improving radiotherapy protocols; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 2000 are reported.

  17. Radiobiology and Epidemiology

    International Nuclear Information System (INIS)

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality in nuclear workers in Belgium and to co-ordinate the Belgian contribution to the 'International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry'; (2) to elucidate the molecular basis of individual susceptibility to ionizing radiation in mammalian embryo during the early phases of its development; (3) to assess the genetic risk of maternal exposure to ionizing radiation; (4) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (5) to monitor the early variations of gene expression induced by ionising radiation and cytokines; (6) to evaluate the use of cytokines and natural substances for improving radiotherapy protocols; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 2000 are reported

  18. Radiobiology and isotopic imaging

    International Nuclear Information System (INIS)

    This 6. workshop occurs after more than 10 years of meaningful scientific exchanges between the National Institute of Radiological Sciences and the Life Science Division of the French Atomic Commission. The aim of the workshops held alternatively in Japan and France every two years is to promote new collaboration and stimulate exchange of scientists. In this respect, encouraging results have been obtained, since young scientists are currently working at the partner's institution; this is highlighted this year, with the presentation of their results as speakers from each country. New projects are under way to enlarge scientific collaboration. This sixth workshop will allocate three days to specialized working groups within the laboratories at the various locations of the Life Science Division. We hope that all participants will take this opportunity to develop further collaborative research activities in connection with the recent major advances in the field of radiobiology and medical imaging. Such a meeting appears of high interest within the context of new nuclear energy developments

  19. A New Crank Arm-Based Load Cell for the 3D Analysis of the Force Applied by a Cyclist

    OpenAIRE

    Alexandre Balbinot; Cleiton Milani; Jussan da Silva Bahia Nascimento

    2014-01-01

    This report describes a new crank arm-based force platform designed to evaluate the three-dimensional force applied to the pedals by cyclists in real conditions. The force platform was designed to be fitted on a conventional competition bicycle crankset while data is transmitted wirelessly through a BluetoothTM module and also stored on a SD card. A 3D solid model is created in the SolidWorks (Dassault Systèmes SOLIDWORKS Corp.) to analyze the static and dynamic characteristics of the crank a...

  20. The DOE Atmospheric Radiation Measurement Program's LES ARM Symbiotic Simulation and Observation (LASSO) Workflow: Initialization, Forcing and Multiscale Data Assimilation

    Science.gov (United States)

    Li, Z.; Cheng, X.; Gustafson, W. I., Jr.; Xiao, H.; Endo, S.; Vogelmann, A. M.; Toto, T.

    2015-12-01

    The Department of Energy Atmospheric Radiation Measurement (ARM) Program is developing a routine large-eddy simulation (LES) modeling framework at the ARM Climate Research Facility sites, known as the "LES ARM Symbiotic Simulation and Observation" (LASSO) Workflow. The routine simulations will be assessed using comprehensive ARM observations of the atmosphere and land-surface states, particularly cloud observations. Since small changes in thermodynamic profiles can manifest large changes in cloud properties, successful simulations require careful initialization, appropriate forcing, and possibly suitable lateral boundary conditions. We use a multiscale data assimilation (MS-DA) system as a major methodology for producing forcing datasets required by the LES modeling. The MS-DA will be implemented in the regional Weather Research and Forecasting (WRF) model at a cloud resolving resolution (~1 km). MS-DA leverages existing reanalyses (e.g., the NCEP North American Regional Reanalysis, NARR) and operational forecasting products (e.g. the North American Mesoscale Forecast System, NAM; the High-Resolution Rapid Refresh, HRRR) products, and takes advantage of ARM observations to directly constrain the spectra of horizontal scales down to a few km. The analysis from the MS-DA allows deriving initial conditions and forcing datasets for a range of spatial and temporal scales, developing hydrometeor forcing, exploring time-varying boundary conditions, and diagnosing other needed thermodynamic variables. It is stressed that the datasets from the MS-DA are integrated with datasets from other sources to form ensembles to account for uncertainties. The methodologies, implementation and evaluations are presented.

  1. Clinical application of ocular trauma score for mechanical ocular injury in armed forces

    Directory of Open Access Journals (Sweden)

    Ying ZHANG

    2011-10-01

    Full Text Available Objective To evaluate the predictive value of ocular trauma score(OTS in mechanical ocular injuries occurring in military forces,and compare the difference of OTS application between ocular injury caused by military training and non-military training.Methods The data of 633 inpatients from armed forces suffering from injury of 665 eyes were retrospectively reviewed.Of the 665 injured eyes,326 were injured during military training and 339 during non-military training.The likelihood of final visual acuity(VA calculated with the OTS score was compared with that by the present OTS study,and the correlation between the score and final VA was then analyzed.Results Compared with the distribution of final VA in standard OTS score,the ratio in category 1 was statistically different in present study(P 0.05.There were significant differences in ratio of category 3 between eyes injured by military and non-military training(P < 0.05,and both ratios in category 1 were significantly different compared with those in standard OTS(P < 0.01,e.g.the ratio of NLP was lower(50% vs 73%,P < 0.01;43% vs 73%,P < 0.01;and the ratio in category 2 was significantly different between the eyes injured by non-military training and standard OTS(P < 0.05.However,the OTS showed positive correlation with final VA in present study(P < 0.0001.Conclusion OTS calculated at initial examination may primarily provide a piece of prognostic information of mechanical ocular injuries,and is of special benefit for deciding a prompt management or for evacuation decision for severe ocular injuries caused by military training.

  2. Frequency of coronary artery disease (cad) risk factors in armed forces

    International Nuclear Information System (INIS)

    To determine the frequency of risk factors of coronary artery disease (CAD) in apparently healthy soldiers of Pakistan Armed Forces. Study Design: Cross sectional descriptive study. Place and Duration of Study: Department of medicine, CMH Okara from July 2012 to Dec 2012. Patients and Methods: The study included 2215 male currently serving soldiers in age range of 18 to 52 years by consecutive sampling. Relevant history, body mass index (BMI), waist circumference (WC) and blood pressure (BP) of each subject were recorded. BMI > 25 kg/m/sup 2/ and WC > 90 cm was considered obesity and abdominal obesity respectively. BP > 140/90 mmHg was defined as hypertension. All the participants of study underwent blood glucose fasting, blood glucose random, ECG recording, personality assessment and lipid profile. Risk estimation was done using Eric Brittain scoring system. Results: In our study group 95.5% patients were having at least 1 risk factor of CAD, 54 % were having 2 to 4 risk factors while 3.93% had > 4 risk factors. Risk estimation of CAD using Eric Brittain scoring system showed that a large proportion of study group had high probability of developing ischemic heart disease in next 6 years. Conclusion: A large proportion of our soldiers are harboring risk of CAD due to increase in frequency of 8 conventional CAD risk factors especially obesity. (author)

  3. The Revolutionary Armed Forces of Colombia (FARC and the Development of Narco-Submarines

    Directory of Open Access Journals (Sweden)

    Michelle Jacome Jaramillo

    2016-03-01

    Full Text Available The Revolutionary Armed Forces of Colombia (FARC have been one of the world's most consistently formidable violent non-state actors over the last forty years. Unsurprisingly, the group has provided one of the most compelling and concerning examples of the level of technical sophistication attainable by sub-state organizations. Over the last two decades the group has carried out an iterative and innovative process that, in reaction to improved detection capabilities, has brought them from depending on disposable go-fast boats to transport drugs to possessing fully submersible and reusable covert vessels for transportation. The following case study will discuss the development of narco-submarines and the underlying motivations behind the pursuit of this complex engineering task. The case study will outline the different phases of the narco-submarine development and highlight FARC’s determination to overcome the challenges present in each design. This discussion will show how FARC’s systematized acquiring of information and expertise has resulted in the accomplishment of fully submersible vessels, capable of transporting more than 10 tons of illicit product.

  4. Mentoring from Afar: Nurse Mentor Challenges in the Canadian Armed Forces.

    Science.gov (United States)

    Neal, Laura D M

    2015-06-01

    There is an integral connection between leadership, mentoring and professional career progression within the nursing profession. The purpose of this article is to examine recommendations and best practices from the literature and provide a basis to construct a formalized successful mentoring dyad program with guidelines on establishing and maintaining a productive mentoring relationship over long distance. Canadian Armed Forces (CAF) nurses practice within a unique domain both domestically and abroad. The military environment incorporates many aspects of mentoring that could benefit significantly by distance interchange. Supported through examining literature within nursing, CAF publications and other professions along with contrasting successful distance mentoring programs, the findings suggest that a top-down, leadership-driven formal mentoring program could be beneficial to CAF nurses. The literature review outlines definitions of terms for mentorship and distance mentoring or e-mentoring. A cross section of technology is now embedded in all work environments with personal communication devices commonplace. Establishing mentoring relationships from afar is practical and feasible. This article provides a guided discussion for nursing leaders, managers and grassroots nurses to implement mentoring programs over distances. The recommendations and findings of this article could have universal applications to isolated nursing environments outside of Canadian military operational frameworks. PMID:26560257

  5. Irom Chanu Sharmila and the Movement against Armed Forces Special Powers Act (AFSPA

    Directory of Open Access Journals (Sweden)

    Aparajita Sharma

    2014-02-01

    Full Text Available This paper, through the narratives of activists and Meira Paibis reiterates the slogan—repeal the Armed Forces Special Powers Act (AFSPA, which is draconian and anti-people in spirit. The atroci- ty, which has been meted out on the people of Manipur because of this Act, is a profound viola- tion of human rights. Rape, mindless killings, kidnapping, fake encounters have been normalised by virtue of this Act. The youths have been badly affected due to the conflict emerging out of this Act which treats people in Manipur as ‘objects’ against the imagined boundaries of the Indian na- tion-state for security from the neighbouring nations. In this process, the lived experiences of the people have been pushed to the periphery against the massive motive of the state to protect bor- ders and the imagined nation, which is a direct offshoot of the legacy of colonialism in India. The paper has tried to capture the history of Manipur on a capsule to concretise the struggle of Irom Sharmila and the ‘hopes’ she gives to the people of Manipur for ‘peace’ and ‘justice’. Alongside, it makes a humble attempt to describe the ‘life’ of Irom Sharmila. In addition, it describes the rage of Manipuris, which have given rise to insurgency asking for ‘freedom’ through various platforms.

  6. Radiobiological effects of metallic nanoparticles

    International Nuclear Information System (INIS)

    Full text: Radiobiological effects of nanoparticles and its cellular mechanism in normal tissue regeneration are investigated. About 2 nm diameter gold nanoaprticies are used in this study with bovine endothelial eells as normal cells and glioma type cells. The imtdiation was conducted using Spring8 synchrotron in Japan and the cell culture studies were performed at the school of Medical Sciences RMIT-University. AuNPs accelerate eells migration esp cially normal endothelial cells. This effect has been observed when AuNPs are introduced into the cells and the cells impregnated with AuNPs migrate faster than the ones without AuNPs. The cells with AuNPs have been found to fill in gaps created in cultures about five times faster than those without AuNPs. The effects have been observed with gaps generated by radiations or when such gaps are made by scratehes 'wounds'. Filling of artificial scratch have been found to be much faster than radiation created gaps. Two aspects of this phenomenon are given; one is biology based where it is thought of disrupts caused by such particles to the cells eytoskeleton org nisation and hence induces different chemical pathways promoting cells motility. The other reason (physics) can be due to Coulomb repulsion force generated by polarised cells pushing the cells into gaps and also cell-polarisation could lead into cells symmetr breaking hence accelerating their motion. Conclusion Radiotherapy treatment efficiency can be improve by using AuNps where dose can be enhance to kill the tumour cells and at the same time helping normal cells to regenerate.

  7. [Medical support of the Armed Forces of the Russian Federation: results of activity and tasks for 2016].

    Science.gov (United States)

    Fisun, A Ya

    2016-01-01

    The author gives an analysis of activity of the medical service of the Armed Forces in 2015 concerning development of normative legal basis for the military health care, improvement of the level of operational and mobilization readiness of subunits of army group, and military-medical institutions, improvement of effectiveness of treatment and evacuation measures, health resort treatment, medical stuff training optimization, sanitary-and-epidemiologic support, material and technical support improvement, adoption of advanced scientific achievements focusing on medical care delivery to army group, active development and increase in medical information systems, telehealth. system. The author gives data characterizing state and level of development of medical service of the Armed Forces and its dynamics. Main tasks and parameters of development of the service in 2016 and up to 2020 are formulated. PMID:27120950

  8. Mode of presentation of patients of dissociative (conversion) disorder at the armed forces institute of mental health

    International Nuclear Information System (INIS)

    To determine the mode of presentation of dissociative disorders presenting at Armed Forces Institute of Mental Health. Study Design: Cross sectional study. Place and Duration of Study: The study was conducted at the Armed Forces Institute of Mental Health (AFIMH) Rawalpindi from 1st June 2013 to 31st August 2013. Patients and Methods: Fifty four patients of dissociative disorders were included in the study by using consecutive non-probability sampling. Category of presentation of dissociative disorders in the participants was determined by the primary mode of presentation and by using international classification of diseases (ICD)-10 diagnostic guidelines. Results: The commonest type of presentation of dissociative disorders was mutism (40.7%), possession state (18.5%), pseudo fits (12.9%) followed by paraparesis (9.2%). Conclusion: Predominantly the patients presented with mutism (dissociative motor disorder). (author)

  9. The Revolutionary Armed Forces of Colombia - People's Army (FARC-EP) Marxist-Leninist insurgency or criminal enterprise?

    OpenAIRE

    Saskiewicz, Paul E.

    2005-01-01

    Approved for public release; distribution is unlimited This thesis argues that the Revolutionary Armed Forces of Colombia- Peopleâ s Army (FARC-EP), Latin Americaâ s oldest and most powerful guerrilla organization, has not abandoned its ideological beliefs and devolved into a criminal enterprise as a result of its immersion in the drug trade and participation in other illicit activities. Rather, the movement remains an ideologically committed, guerrilla insurgency whose strategic objecti...

  10. The evolution of the curriculum of the Industrial College of the Armed Forces, 1924-1988 : a search for rigor

    OpenAIRE

    Gest, Robert

    1990-01-01

    This study examined the curriculum evolution process of the Industrial College of the Armed Forces (ICAF) and its predecessor, the Army Industrial College (AIC), as it was influenced by a variety of factors between the years 1924 and 1988. Most of the published material used for this study was found in the library of the National Defense University, Fort Lesley J. McNair, Washington, DC. Additionally, current and past College faculty and staff members were interviewed. ...

  11. The SLOWPOKE-2 nuclear reactor at the Royal Military College of Canada: applications for the Canadian Armed Forces

    International Nuclear Information System (INIS)

    The Royal Military College of Canada (RMCC) has a 20 kW SLOWPOKE-2 nuclear research reactor which is used for teaching and research. Since its commissioning, the reactor facility and instruments have been continuously upgraded to develop and enhance nuclear capabilities for the Canadian Armed Forces (CAF). Specific applications of neutron activation analysis (NAA), delayed neutron counting (DNC) and neutron imaging relevant to the CAF are discussed. (author)

  12. The SLOWPOKE-2 nuclear reactor at the Royal Military College of Canada: applications for the Canadian Armed Forces

    International Nuclear Information System (INIS)

    The Royal Military College of Canada (RMCC) has a 20 kW SLOWPOKE-2 nuclear research reactor which is used for teaching and research.Since its commissioning, the reactor facility and instruments have been continuously upgraded to develop and enhance nuclear capabilities for the Canadian Armed Forces (CAF). Specific applications of neutron activation analysis (NAA), delayed neutron counting (DNC) and neutron imaging relevant to the CAF are discussed. (author)

  13. A New Crank Arm-Based Load Cell for the 3D Analysis of the Force Applied by a Cyclist

    Directory of Open Access Journals (Sweden)

    Alexandre Balbinot

    2014-12-01

    Full Text Available This report describes a new crank arm-based force platform designed to evaluate the three-dimensional force applied to the pedals by cyclists in real conditions. The force platform was designed to be fitted on a conventional competition bicycle crankset while data is transmitted wirelessly through a BluetoothTM module and also stored on a SD card. A 3D solid model is created in the SolidWorks (Dassault Systèmes SOLIDWORKS Corp. to analyze the static and dynamic characteristics of the crank arm by using the finite elements technique. Each crankset arm is used as a load cell based on strain gauges configured as three Wheatstone bridges. The signals are conditioned on a printed circuit board attached directly to the structure. The load cell showed a maximum nonlinearity error between 0.36% and 0.61% and a maximum uncertainty of 2.3% referred to the sensitivity of each channel. A roller trainer equipped with an optical encoder was also developed, allowing the measurement of the wheel’s instantaneous velocity.

  14. Emergency Surgery after Failed Percutaneous Transmitral Commissurotomy (PTMC) at Armed Forces Institute of Cardiology (AFIC)

    International Nuclear Information System (INIS)

    Objective: The aim of this study was to analyze the outcome of emergency after PTMC. Design: A cross-sectional study. Place and Duration of Study: Armed Forces Institute of Cardiology (AFIC) Rawalpindi from January 2005 to June 2009. Patients and Methods: A cross-sectional study of 12 patients (2.3 percent) out of 523 who underwent PTMC and developed significant mitral regurgitation (MR) or cardiac tamponade (CT) was examined to analyze the outcome of emergency surgery. Transthoracic echocardiography (TTE) was used to select patients of MS with minimal calcification and transesophageal echocardiography (TEE) was used to rule out left atrial (LA) clot. Inuoe balloon was used in all cases for PTMC. Results: Out of twelve who presented for surgery after failed PTMC, 9(75 percent) had significant MR and 3(25 percent) had CT. Majority of patients were female (83.3 percent) with mean age of 30.9+-5.12 years. In patients with MR, anterior mitral leaflet (AML) tear was found in 8(66.7 percent) and posterior mitral leaflet tear in 1(8.3 percent). LA clot was found in 1(8.3 percent) patient who caused cerebral infarction. All patients underwent mitral valve replacement (MVR) with prosthetic valve on cardiopulmonary bypass (CPB). Two patients (16.7 percent) died; one because of cerebral infarction and one due to low cardiac output syndrome (LCOS). Conclusion: With increasing experience of PTMC the magnitude of failure cases is decreasing as was seen in our case in which failed percentage was just 2.3 percent. Moreover, percentage of success of emergency surgery was good i.e. 83.3 percent. In case of failure a well coordinated effort between cardiologist and surgical team can prevent mortality significantly. (author)

  15. [Risk factors for accidents during sports while serving in German armed forces].

    Science.gov (United States)

    Gundlach, N; Sammito, S; Böckelmann, I

    2012-03-01

    In the German Armed Forces sports activities should bring the benefits of good health and trained fitness which are the hallmarks of sportsmen. In order to achieve this aim it is important to avoid accidents which negate the benefit of sports. Until today there appear to be no studies in existence which demonstrate the risk factors of sports activities undertaken while in military service. Equivalent studies on civilian sport activities are scarcely comparable. To find out risk factors for accidents with any period of recovery we followed sports accidents while on duty in a German barracks with 4,300 soldiers over a two-year period. Additionally we asked about the time needed for recovery from each accident, parameters of lifestyle, the body mass index and the possibility of a nightshift before each accident. We examined a minimum of 410 accidents. We found associations between the accidents studied and particular risk factors, including doing sports more than two times a week, being active in a fitness or sports club, having the accident together with another sportsman and doing a nightshift before the day of the accident. Bad ground conditions contributed to a large number of accidents. A body mass index of 25 and higher had a significantly prolonged time for recovery. To avoid accidents, sport and ground conditions should be adapted to each other. In addition, overweight people are not only compromised for cardiovascular and neurological diseases but also have a higher risk of needing a prolonged time for recovery, thus it is important that overweight should be avoided and not only just be treated. PMID:22422284

  16. Microirradiation techniques in radiobiological research

    Indian Academy of Sciences (India)

    Guido A Drexler; Miguel J Ruiz-Gómez

    2015-09-01

    The aim of this work is to review the uses of laser microirradiation and ion microbeam techniques within the scope of radiobiological research. Laser microirradiation techniques can be used for many different purposes. In a specific condition, through the use of pulsed lasers, cell lysis can be produced for subsequent separation of different analytes. Microsurgery allows for the identification and isolation of tissue sections, single cells and subcellular components, using different types of lasers. The generation of different types of DNA damage, via this type of microirradiation, allows for the investigation of DNA dynamics. Ion microbeams are important tools in radiobiological research. There are only a limited number of facilities worldwide where radiobiological experiments can be performed. In the beginning, research was mostly focused on the bystander effect. Nowadays, with more sophisticated molecular and cellular biological techniques, ion microirradiation is used to unravel molecular processes in the field of radiobiology. These include DNA repair protein kinetics or chromatin modifications at the site of DNA damage. With the increasing relevance of charged particles in tumour therapy and new concepts on how to generate them, ion microbeam facilities are able to address unresolved questions concerning particle tumour therapy.

  17. 32 CFR Appendix A to Part 631 - Armed Forces Disciplinary Control Board Procedures Guide

    Science.gov (United States)

    2010-07-01

    .... (11) State and local school board or education officials. (12) Any other representation deemed... detrimental to the good order and discipline, health, morale, welfare, safety, and morals of Armed...

  18. How is psychological therapy experienced by ex UK armed forces members? An exploration through personal narrative of cross-cultural encounters

    OpenAIRE

    Stack, Camilla Rosaleen

    2013-01-01

    The aim of the study was to explore through narrative inquiry the lived experiences of ex-UK armed forces members of psychological therapy, and contribute much needed qualitative findings to a research field currently dominated by quantitative studies. Interview conversations were conducted with ten participants who had served in the UK armed forces and had had weekly psychological therapy over a period of at least a few months since leaving. Narrative inquiry was adopted in analysing the tra...

  19. The FORCE Fitness Profile--Adding a Measure of Health-Related Fitness to the Canadian Armed Forces Operational Fitness Evaluation.

    Science.gov (United States)

    Gagnon, Patrick; Spivock, Michael; Reilly, Tara; Mattie, Paige; Stockbrugger, Barry

    2015-11-01

    In 2013, the Canadian Armed Forces (CAF) implemented the Fitness for Operational Requirements of Canadian Armed Forces Employment (FORCE), a field expedient fitness test designed to predict the physical requirements of completing common military tasks. Given that attaining this minimal physical fitness standard may not represent a challenge to some personnel, a fitness incentive program was requested by the chain of command to recognize and reward fitness over and above the minimal standard. At the same time, it was determined that the CAF would benefit from a measure of general health-related fitness, in addition to this measure of operational fitness. The resulting incentive program structure is based on gender and 8 age categories. The results on the 4 elements of the FORCE evaluation were converted to a point scale from which normative scores were derived, where the median score corresponds to the bronze level, and silver, gold, and platinum correspond to a score which is 1, 2, and 3 SDs above this median, respectively. A suite of rewards including merit board point toward promotions and recognition on the uniform and material rewards was developed. A separate group rewards program was also tabled, to recognize achievements in fitness at the unit level. For general fitness, oxygen capacity was derived from FORCE evaluation results and combined with a measure of abdominal circumference. Fitness categories were determined based on relative risks of mortality and morbidity for each age and gender group. Pilot testing of this entire program was performed with 624 participants to assess participants' reactions to the enhanced test, and also to verify logistical aspects of the electronic data capture, calculation, and transfer system. The newly dubbed fitness profile program was subsequently approved by the senior leadership of the CAF and is scheduled to begin a phased implementation in June 2015. PMID:26506187

  20. ARRESTS AND LIQUIDATIONS OF WOUNDED MEMBERS OF THE CROATIAN ARMED FORCES (HOS) TAKEN FROM HOSPITALS IN ZAGREB BY YUGOSLAV ARMED FORCES IN MAY AND JUNE OF 1945 IN THE RECORDS OF STATE ARCHIVES IN ZAGREB

    OpenAIRE

    Matković, Blanka

    2011-01-01

    Based on documents from the two hospitals in Zagreb, Croatia (‘Zakladna’ and ‘Sisters of Mercy’), it is possible, at least to some degree, to reconstruct what happened to the hospitalized members of the Croatian Armed Forces (HOS), most of whom were suffering from heavy injuries and were bedridden when the Yugoslav Army entered Zagreb on May 8, 1945 and found them in the hospitals. Even though contemporary historians do not have access to documents from other Croatian hospitals (because they ...

  1. Radiobiology software for educational purpose

    International Nuclear Information System (INIS)

    To understand radio-nuclide therapy and the basis of radiation protection, it is essential to understand radiobiology. With limited time for classroom teaching and limited time and resources for radiobiology experiments students do not acquire firm grasp of theoretical mathematical models and experimental knowledge of target theory and Linear quadratic models that explain nature of cell survival curves. We believe that this issue might be addressed with numerical simulation of cell survival curves using mathematical models. Existing classroom teaching can be reoriented to understand the subject using the concept of modeling, simulation and virtual experiments. After completion of the lecture, students can practice with simulation tool at their convenient time. In this study we have developed software that can help the students to acquire firm grasp of theoretical and experimental radiobiology. The software was developed using FreeMat ver 4.0, open source software. Target theory, linear quadratic model, cell killing based on Poisson model have been included. The implementation of the program structure was to display the menu for the user choice to be made and then program flows depending on the users choice. The program executes by typing 'Radiobiology' on the command line interface. Students can investigate the effect of radiation dose on cell, interactively. They can practice to draw the cell survival curve based on the input and output data and they can also compare their handmade graphs with automatically generated graphs by the program. This software is in the early stage of development and will evolve on user feedback. We feel this simulation software will be quite useful for students entering in the nuclear medicine, radiology and radiotherapy disciplines. (author)

  2. Forças armadas para quê? Para isso Armed forces... for what? For this

    Directory of Open Access Journals (Sweden)

    Domício Proença Júnior

    2011-12-01

    Full Text Available Responde-se de maneira estrutural à pergunta: para que se tem Forças Armadas no Brasil? Isso leva a um trajeto expositivo que considera os contextos estratégicos e domésticos à luz das determinações constitucionais e dos termos de acordos internacionais que constrangem as alternativas brasileiras de uso de força. Conclui-se que o Brasil tem apenas três tarefas concretas para suas Forças Armadas: a defesa do território, a participação em ações internacionais e a garantia da lei e da ordem, circunscrito em todos os casos ao uso de armamentos convencionais. Responde-se à pergunta de partida afirmando que se tem Forças Armadas para sustentar a capacidade de realizar estas tarefas ao longo do tempo e em qualquer momento. Como e quanto se sustenta tal capacidade são os critérios essenciais para a formulação, condução e avaliação da política de defesa do Brasil.This article offers a structural answer to the question: what are Brazil's armed forces for? This leads to the appreciation of Brazil's strategic and domestic contexts of the use of armed force. It considers the constitutional imperatives and the terms of international agreements that curtail Brazilian alternatives. It argues that Brazil has only three concrete tasks for its armed forces: the defense of its territory, the participation in international missions, and the guarantee of law and order, being constrained further to the use of conventional weapons. It answers the question it began with as follows: Brazil's armed forces exist to sustain the capacity of carrying out these tasks over time and at any time. It concludes that how and how well a Brazilian defense policy sustains this capacity are the paramount criteria for its conception, management and evaluation.

  3. Forced Conscription of Children during Armed Conflict: Experiences of Former Child Soldiers in Northern Uganda

    Science.gov (United States)

    Vindevogel, Sofie; Coppens, Kathleen; Derluyn, Ilse; De Schryver, Maarten; Loots, Gerrit; Broekaert, Eric

    2011-01-01

    Objective: Child soldiering can be considered as one of the worst practices of institutionalized child abuse. However, little is known about the scope and nature of this abuse and the consequent experiences of children enrolled in an armed faction. This research aims at enriching the knowledge on the experiences of child soldiers in the Lord's…

  4. Radiotherapy treatment planning linear-quadratic radiobiology

    CERN Document Server

    Chapman, J Donald

    2015-01-01

    Understand Quantitative Radiobiology from a Radiation Biophysics PerspectiveIn the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses.Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer TreatmentsThe book compil

  5. A DIVERSE SOCIETY, A REPRESENTATIVE MILITARY? THE COMPLEXITY OF MANAGING DIVERSITY IN THE SOUTH AFRICAN ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Lindy Heinecken

    2011-08-01

    Full Text Available After providing a brief background as to why issues of diversity managementwithin armed forces have become important internationally, this article outlines thediversity challenges facing the South African National Defence Force (SANDF.The first part of the article describes how the racial, language/ethnic and genderprofile of the SANDF has changed since 1994 and the tensions this has evoked. Thesecond part provides a brief conceptual framework against which diversitymanagement in the SANDF can be interpreted, whereafter the various diversitymanagement programmes instituted over the years to cultivate a respect for diversityare outlined. It is argued that the predominant emphasis on ‘workplace diversity’ atthe cost of ‘valuing diversity’ has meant that existing stereotypes and tensionswithin the ranks have remained, with dire consequences not only for thecohesiveness and effectiveness of the SANDF, but also for civil-military relations.

  6. Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats

    Science.gov (United States)

    2014-01-01

    Background and purpose Both the immobilization of the unaffected arm combined with physical therapy (forced arm use, FAU) and voluntary exercise (VE) as model for enriched environment are promising approaches to enhance recovery after stroke. The genomic mechanisms involved in long-term plasticity changes after different means of rehabilitative training post-stroke are largely unexplored. The present investigation explored the effects of these physical therapies on behavioral recovery and molecular markers of regeneration after experimental ischemia. Methods 42 Wistar rats were randomly treated with either forced arm use (FAU, 1-sleeve plaster cast onto unaffected limb at 8/10 days), voluntary exercise (VE, connection of a freely accessible running wheel to cage), or controls with no access to a running wheel for 10 days starting at 48 hours after photothrombotic stroke of the sensorimotor cortex. Functional outcome was measured using sensorimotor test before ischemia, after ischemia, after the training period of 10 days, at 3 and 4 weeks after ischemia. Global gene expression changes were assessed from the ipsi- and contralateral cortex and the hippocampus. Results FAU-treated animals demonstrated significantly improved functional recovery compared to the VE-treated group. Both were superior to cage control. A large number of genes are altered by both training paradigms in the ipsi- and contralateral cortex and the hippocampus. Overall, the extent of changes observed correlated well with the functional recovery obtained. One category of genes overrepresented in the gene set is linked to neuronal plasticity processes, containing marker genes such as the NMDA 2a receptor, PKC ζ, NTRK2, or MAP 1b. Conclusions We show that physical training after photothrombotic stroke significantly and permanently improves functional recovery after stroke, and that forced arm training is clearly superior to voluntary running training. The behavioral outcomes seen correlate with

  7. [Contribution of the French Armed Forces Health Services to relief in Indonesia following the tsunami on December 26, 2004].

    Science.gov (United States)

    Meynard, J B; Nau, A; Halbert, E; Lelaidier, M; Robin, F; Todesco, A

    2005-01-01

    As of early January 2005, the French Armed Forces Health Services were on the ground in Indonesia to contribute to relief operations following the tsunami in Indonesia on December 26, 2004. Findings of preliminary investigation performed upon deployment of the first French elements demonstrated that a major priority was to speed up vaccination against measles in children between the ages of 6 months and 15 years. A vaccination campaign was planned in cooperation with Indonesian authorities and UNICEF. Implementation involved training of personnel and setting up vaccination clinics in refugee camps, schools, and neighborhoods in the city of Meulaboh. The vaccination campaign was hampered by a number of problems in particular involving logistics and required constant supervision. A survey to evaluate the results of the campaign in terms of vaccination coverage showed that the objective of vaccinating 70% of children in refugee camps was achieved. The survey provided other child health indicators that will be helpful to local authorities taking over after the departure of the French Armed Forces Health Services. PMID:16038345

  8. Bridge Maintenance Robotic Arm:Mechanical Technique to Reduce the Nozzle Force of a Sandblastine Rig

    Institute of Scientific and Technical Information of China (English)

    Nathan Kirchner; Gavin Paul; D.K. Liu

    2006-01-01

    This paper describes a mechanical technique to reduce the nozzle reaction force of a sandblasting rig. A theoretical evaluation of the magnitudes and direction of action of typical sandblasting nozzle forces has been conducted and a technique for exploiting available energy in order to reduce the magnitude of the forces at the nozzle has been developed.Experimental results from a variety of tests in different configurations have confirmed the theoretically determined force magnitude's accuracy and shown that forces of up to 106N can be present in typical sandblasting operations. The results have also shown that an up to 77% reduction of force at the nozzle can be achieved by applying the developed mechanicaltechnique.

  9. ASPECTS OF SOCIAL RESPONSIBILITY OF THE ARMED FORCES ACADEMY OF GEN. M.R.ŠTEFÁNIK, LIPTOVSKÝ MIKULÁŠ, SLOVAKIA

    Directory of Open Access Journals (Sweden)

    Soňa JIRÁSKOVÁ

    2014-10-01

    Full Text Available The article deals with the issue of socially responsible behavior in organizations, while the main emphasis is on the social responsibility of universities. The first part of the article briefly describes the concept of social responsibility and the second part presents a case study on the current state of activities related to socially responsible behavior within the Armed Forces Academy of gen. M. R. Štefánik in Liptovský Mikuláš. CSR activities which were implemented at the Armed Forces Academy of gen. M. R. Štefánik can be an example of good practice for other universities in Slovakia and abroad.

  10. Energy and Security: future-oriented studies for the Swedish Armed Forces; Energi och saekerhet: framtidsinriktade omvaerldsanalyser foer Foersvarsmakten

    Energy Technology Data Exchange (ETDEWEB)

    Oestensson, Malin; Jonsson, Daniel K.; Magnusson, Roger; Dreborg, Karl Henrik

    2009-01-15

    The report provides a basis for the Armed Forces long-term planning, and how changes in the global energy supply may mean new challenges and threats, as well as the advantages and disadvantages that can be associated with different future energy solutions for Armed Forces own activities, primarily relating to fuel and power during operation. One conclusion is that the potential conflict between energy security and climate-security can lead to far-reaching security implications and that continued global fossil dependency contributes to increased safety of political and military focus on a number of potential conflicts. A new such area may be the Arctic, as in the wake of climate change will become available for exploitation. Large scale global renewable energy can bring greater geographical spread - and reduced pressure on existing 'hot-spots'. Nuclear power is unlikely to be influential in the overall global energy security, but security problems associated with the production of nuclear materials can spread and be strengthened. Furthermore, the energy problems of connected to gaps between rich and poor, which may lead to social friction and conflict. The trend toward increased nationalisation and politicization of the energy is in contrast to free trade and market liberalism and may lead to further militarization of energy resources. Bilateral energy contracts may result in division within the EU and create a hindrance to joint positions and actions, such as in international efforts. As for Armed Forces own future energy solutions, the knowledge of alternative fuels (eg alcohols, diesel variants, gaseous fuels) and energy converters (eg hybrid vehicles, fuel cells) is reviewed. The following alternative principle solutions fuel and power are discussed: 1. Power from small-scale electricity generation via solar cells and small wind farms and power stations with liquid fuel as a supplement. Transport with plug-in hybrid vehicles, i.e. liquid propellants in

  11. Exploring pre-enlistment and military factors associated with the morale of members of the UK Armed Forces.

    Science.gov (United States)

    Murphy, Dominic; Sharp, Duncan

    2011-01-01

    There is a paucity of evidence to show the importance of morale within military units. The aim of this study was to explore how pre-enlistment and postenlistment factors influence morale and to ascertain which has the greater contribution. A cross-sectional study of the UK military involved in operations to Iraq was conducted between 2004 and 2006. The sample was randomly selected and was representative of the UK Armed Forces. Data were collected via questionnaires and included measures on unit cohesion and leadership, childhood adversity, and current service factors (e.g., whether individuals deployed as individuals or within formed units). Although childhood adversity was found to affect self-reported morale, current service factors were found to have a greater influence. PMID:21305954

  12. Self-reported side-effects associated with use of dietary supplements in an armed forces population.

    Science.gov (United States)

    Austin, Krista G; Farina, Emily K; Lieberman, Harris R

    2016-03-01

    Approximately 60-70% of Armed Forces personnel consume a dietary supplement (DS) at least once a week and there have been numerous reports of severe adverse events among DS users. This study assessed patterns of DS use and self-reported side-effects among 4400 Armed Forces personnel using a paper-and-pencil survey. Multivariable logistic regression was used to examine associations between patterns of DS use and self-reported side-effects. Sixty-nine percent of personnel surveyed reported using a DS. Seven percent of DS users reported experiencing abnormal heart beats, 6% tremors, 5% stomach pain, 3% dizziness, and 3% numbness/tingling and they believed these symptoms were associated with the use of DS. After adjustment for use of other DS classes, total supplement use, and demographic characteristics, protein supplement users were more likely than non-users to report numbness/tingling; combination product users were more likely to report experiencing abnormal heart beats, stomach pain, dizziness, tremors, and numbness/tingling; and users of purported steroid analogues were more likely to report dizziness. Use of more than one DS per week was associated with an increased likelihood of reporting side-effects. Respondents with a higher body mass index were more likely to report side-effects. Further research is necessary to determine whether self-reported side-effects associated with multiple DS use and some DS classes impact the long-term health or performance of service members. Surveillance of military populations using surveys like this one may provide a method for detecting adverse health events of DS before they are apparent in the civilian population. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26526399

  13. Optimización de la agudeza visual en las FAS Optimization of visual acuity in Spanish Armed Forces

    Directory of Open Access Journals (Sweden)

    J. Medin Catoira

    2011-06-01

    Full Text Available Introducción: La existencia de una agudeza visual óptima es requerida para la mayor parte de las actividades del personal de las FAS, pero se hace estrictamente necesaria en el despliegue dentro del teatro de operaciones internacional. Material y Método: Hemos realizado un estudio sobre el registro de la agudeza visual en un grupo aleatorio (n = 54 durante los reconocimientos periódicos de permanencia realizados en nuestro centro. Resultados: Sólo 3 casos (5,56% reconocen ver mal; 20 (37,04% han utilizado corrección en algún momento de su vida; 12 (22,22% utilizan corrección; en 32 (60,38% sería altamente recomendable el uso de corrección. Ningún caso (0% de los usuarios de corrección posee corrección de repuesto (en gafas. Conclusión: Se hace incidencia en el control y registro de los parámetros visuales en el personal de las FAS, especialmente en actividades de riesgo y despliegue internacional.Introduction: The existence of an optimal visual acuity is required for most of the activities of the membrers of the Armed Forces, but it is strictly necessary in the deployment within the international theater. Materials and Methods: We conducted a study of visual acuity in a random group of periodical surveys in our center. Results: Only 3 cases (5.56% recognize look bad; 20 (37.04% have used correction at some point in their lives; 12 (22.22% used correction; in 32 cases (60.38% was highly recommended the use of correction. No cases (0% of users of correction has a duplicate of it (in glasses. Conclusions: The study suggests the need for better surveillance and control of visual parameters of the Armed Forces members, especially in risky activities and international deployment.

  14. Radiobiology

    International Nuclear Information System (INIS)

    The effects of metridazole and nitroimidazole on the survival time of cultured hamster cells following exposure to various doses and dose rates of 60Co γ radiation or neutrons were studied. Both were found to increase the radiosensitivity of the cells. Data are included on the modifying effects of neutron spectra, energy levels, LET, OER, dose, and dose fractionation schedules on the γ and neutron sensitivity of cultured hamster cells. Studies on the sensitivity of cultured hamster cells and normal liver and hepatoma cells to hyperthermia and hypoxia, with and without the added effects of x irradiation showed that heat treatment at 430C enhanced the radiosensitivity of the cells, with hypoxic cells being the most sensitive. A system was developed for the study of radioinduced carcinogenesis in cultured hamster embryo cells. Preliminary data are presented on the dose response relationships for transformation following exposure to x radiation or neutrons. (U.S.)

  15. A Climatology of Midlatitude Continental Clouds from the ARM SGP Site. Part II; Cloud Fraction and Surface Radiative Forcing

    Science.gov (United States)

    Xi, B.; Minnis, P.

    2006-01-01

    Data collected at the Department of Energy Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Central Facility (SCF) are analyzed to determine the monthly and hourly variations of cloud fraction and radiative forcing between January 1997 and December 2002. Cloud fractions are estimated for total cloud cover and for single-layered low (0-3 km), middle (3-6 km), and high clouds (more than 6 km) using ARM SCG ground-based paired lidar-radar measurements. Shortwave (SW) and longwave (LW) fluxes are derived from up- and down-looking standard precision spectral pyranometers and precision infrared radiometer measurements with uncertainties of approximately 10 Wm(exp -2). The annual averages of total, and single-layered low, middle and high cloud fractions are 0.49, 0.11, 0.03, and 0.17, respectively. Both total and low cloud amounts peak during January and February and reach a minimum during July and August, high clouds occur more frequently than other types of clouds with a peak in summer. The average annual downwelling surface SW fluxes for total and low clouds (151 and 138 Wm(exp-2), respectively) are less than those under middle and high clouds (188 and 201 Wm(exp -2), respectively), but the downwelling LW fluxes (349 and 356 Wm(exp -2)) underneath total and low clouds are greater than those from middle and high clouds (337 and 333 Wm(exp -2)). Low clouds produce the largest LW warming (55 Wm(exp -2) and SW cooling (-91 Wm(exp -2)) effects with maximum and minimum absolute values in spring and summer, respectively. High clouds have the smallest LW warming (17 Wm(exp -2)) and SW cooling (-37 Wm(exp -2)) effects at the surface. All-sky SW CRF decreases and LW CRF increases with increasing cloud fraction with mean slopes of -0.984 and 0.616 Wm(exp -2)%(exp -1), respectively. Over the entire diurnal cycle, clouds deplete the amount of surface insolation more than they add to the downwelling LW flux. The calculated CRFs do not appear to be significantly

  16. Determination of the electrostatic lever arm of carbon nanotube field effect transistors using Kelvin Force Microscopy

    OpenAIRE

    Brunel, David; Deresmes, Dominique; Melin, Thierry

    2009-01-01

    We use Kelvin Force Microscopy (KFM) to study the electrostatic properties of single-walled Carbon Nanotube Field Effect Transistor devices (CNTFETs) with backgate geometry at room temperature. We show that KFM maps recorded as a function of the device backgate polarization enable a complete phenomenological determination of the averaging effects associated with the KFM probe side capacitances, and thus, to obtain KFM measurements with quantitative character. The value of the electrostatic le...

  17. Radiobiological comparison of pions and heavy ions

    International Nuclear Information System (INIS)

    The physical and radiobiological differences between some aspects of pions and heavy ions are discussed, followed by a discussion of acute and late effects of high LET radiations compared to low LET radiations

  18. The mental health of the UK Armed Forces: where facts meet fiction

    Directory of Open Access Journals (Sweden)

    Elizabeth J. F. Hunt

    2014-08-01

    Full Text Available A substantial amount of research has been conducted into the mental health of the UK military in recent years. This article summarises the results of the various studies and offers possible explanations for differences in findings between the UK and other allied nations. Post-traumatic stress disorder (PTSD rates are perhaps surprisingly low amongst British forces, with prevalence rates of around 4% in personnel who have deployed, rising to 6% in combat troops, despite the high tempo of operations in recent years. The rates in personnel currently on operations are consistently lower than these. Explanations for the lower PTSD prevalence in British troops include variations in combat exposures, demographic differences, higher leader to enlisted soldier ratios, shorter operational tour lengths and differences in access to long-term health care between countries. Delayed-onset PTSD was recently found to be more common than previously supposed, accounting for nearly half of all PTSD cases; however, many of these had sub-syndromal PTSD predating the onset of the full disorder. Rates of common mental health disorders in UK troops are similar or higher to those of the general population, and overall operational deployments are not associated with an increase in mental health problems in UK regular forces. However, there does appear to be a correlation between both deployment and increased alcohol misuse and post-deployment violence in combat troops. Unlike for regular forces, there is an overall association between deployment and mental health problems in Reservists. There have been growing concerns regarding mild traumatic brain injury, though this appears to be low in British troops with an overall prevalence of 4.4% in comparison with 15% in the US military. The current strategies for detection and treatment of mental health problems in British forces are also described. The stance of the UK military is that psychological welfare of troops is

  19. Command-wide teleradiology for U.S. armed forces in Korea

    Science.gov (United States)

    Mun, Seong K.; Bryant, Gordon V.; Young, Harold; Sheehy, Monet R.; Willis, Charles E.; Goeringer, Fred

    1992-07-01

    There are 17 U.S. military medical treatment facilities scattered in the Republic of Korea to provide health care for approximately 40,000 U.S. troops and their dependents. Only three Army and one Air Force radiologist are assigned for radiological diagnosis. In some areas, report turn-around time can be as long as two weeks. An extensive teleradiology network is planned as part of an MDIS implementation program to improve the quality of radiological service overcoming the distance and time barriers.

  20. Fundamental aspects of LET in radiobiology

    International Nuclear Information System (INIS)

    Some of the radiobiological features of radiation studies using radiations with different distributions of LET or y have been discussed, with emphasis on the areas of doubt. A considerable amount of data can be explained reasonably well, but some very basic questions remain unanswered, such as how much radiation injury is due to damage to DNA and why does OER go down as LET rises. Further studies using radiations of different LET are essential to help solve basic problems in radiobiology

  1. FACING CHILD SOLDIERS, MORAL ISSUES, AND “REAL SOLDIERING”: ANTHROPOLOGICAL PERSPECTIVES ON PROFESSIONAL ARMED FORCES*

    Directory of Open Access Journals (Sweden)

    Eyal Ben-Ari

    2011-08-01

    Full Text Available In today’s world, adolescents and children sometimes act as combatants whodirectly participate in hostilities. Yet more often they are deployed as auxiliaries (forexample, as lookouts or messengers or in various support roles (as gardening, roadmaintenance, delivery of food, cleaning, cooking, conveying goods and providingsexual services (Boothby and Knudsen 2000. Finally, under certain circumstances,adolescents and children may be used as human shields or for propaganda purposesby government or opposition forces (Boyden and De Berry 2004:xii; United Nations2002:13. Since the late 1970s, a number of international conventions have beenpromulgated to limit the use of these young people, but children continue to bedeployed in parts of the world and overwhelmingly in sub-Saharan Africa. Estimatesas to their numbers vary. Human Rights Watch (2007, a human rights lobby,estimates that there are between 200 000 and 300 000 such youngsters in armedconflicts in over twenty countries.

  2. A Climatology of Midlatitude Continental Clouds from the ARM SGP Central Facility. Part II; Cloud Fraction and Radiative Forcing

    Science.gov (United States)

    Dong, Xiquan; Xi, Baike; Minnis, Patrick

    2006-01-01

    Data collected at the Department of Energy Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) central facility are analyzed for determining the variability of cloud fraction and radiative forcing at several temporal scales between January 1997 and December 2002. Cloud fractions are estimated for total cloud cover and for single-layer low (0-3 km), middle (3-6 km), and high clouds (greater than 6 km) using ARM SGP ground-based paired lidar-radar measurements. Shortwave (SW), longwave (LW), and net cloud radiative forcings (CRF) are derived from up- and down-looking standard precision spectral pyranometers and precision infrared radiometer measurements. The annual averages of total, and single-layer, nonoverlapped low, middle and high cloud fractions are 0.49, 0.11, 0.03, and 0.17, respectively. Total and low cloud amounts were greatest from December through March and least during July and August. The monthly variation of high cloud amount is relatively small with a broad maximum from May to August. During winter, total cloud cover varies diurnally with a small amplitude, mid-morning maximum and early evening minimum, and during summer it changes by more than 0.14 over the daily cycle with a pronounced early evening minimum. The diurnal variations of mean single-layer cloud cover change with season and cloud height. Annual averages of all-sky, total, and single-layer high, middle, and low LW CRFs are 21.4, 40.2, 16.7, 27.2, and 55.0 Wm(sup -2), respectively; and their SW CRFs are -41.5, -77.2, -37.0, -47.0, and -90.5 Wm(sup -2). Their net CRFs range from -20 to -37 Wm(sup -2). For all-sky, total, and low clouds, the maximum negative net CRFs of -40.1, -70, and -69.5 Wm(sup -2), occur during April; while the respective minimum values of -3.9, -5.7, and -4.6 Wm(sup -2), are found during December. July is the month having maximum negative net CRF of -46.2 Wm(sup -2) for middle clouds, and May has the maximum value of -45.9 Wm(sup -2) for high clouds. An

  3. Hello Music Lady: Have You Brought A New Instrument Today? A Music Therapy Group for Children of Families in the UK Armed Forces.

    Directory of Open Access Journals (Sweden)

    Becky White

    2009-11-01

    Full Text Available The paper describes a music therapy group that took place in a UK primary school on an armed forces base.  The school described is the only state school in the UK for families in the armed forces.  The families staying on the base are in transition for reasons such as, family break-up, domestic problems, leaving the forces, emergency evacuation from overseas, and transition between postings.  This paper traces how the group evolved over eleven months.  It focuses on the practical considerations required when setting up a music therapy group.  It describes the thought processes I went through in doing this work, and looks at how the work was integrated into the school.  It considers the setting up of the group, providing a framework, working with staff, structuring the sessions, and how the group ended. 

  4. Radiobiology and radiation protection. Recent developments and future trends in radiobiology

    International Nuclear Information System (INIS)

    The 28th annual meeting of the Fachverband fuer Strahlenschutz, held from October 23 - 25, 1996 in Hannover, discussed the various aspects of the leading theme, radiation protection and radiobiology, recent developments and future trends in radiobiology. The papers presented in the proceedings volume address the three main aspects: (1) Mechanisms of the radiation effects - molecular and cellular mechanisms, genetic and prenatal radiation effects, cancerogenesis and mutagenesis; (2) Novel methods in radiobiology research: microdosimetry from the biological angle, novel methods in molecular biology including computerized simulation of DNA, methods of biological dosimetry, radiobiological aspects of neutrons and other densely ionizing radiation (Pt, Rn); (3) Knowledge and concepts for radiological protection: individual radiosensitivity, radiobiological aspects in medical applications of ionizing radiation, accidents in industry, radiation exposure in aeronautics and astronautics. (vhe)

  5. The impact of an educational film on promoting knowledge and attitudes toward HIV in soldiers of the Serbian armed forces

    Directory of Open Access Journals (Sweden)

    Jadranin Željko

    2015-01-01

    Full Text Available Background/Aim. Millions of soldiers around the world represent one of the most vulnerable populations regarding exposure to human immunodeficiency virus (HIV infection. The programs for HIV prevention remain the most viable approach to reducing the spread of HIV infection. Very few studies have tested the effectiveness of HIV preventive interventions undertaken in military population. The aim of this study was to determine the effectiveness of educational film to transfer knowledge about HIV infection to soldiers. Methods. We performed a quasi-experimental study among 102 soldiers of the Serbian Armed Forces. The experimental intervention consisted of the HIV knowledge pre-questionnaire, watching a film on HIV knowledge, then the post-HIV knowledge questionnaire. The results of pre-and post-HIV knowledge questionnaires were compared. Results. There were 23 questions in the test. The average total score on the questionnaire before watching the film was 18.23 and after watching it was 20.14, which was statistically significant difference (p < 0.001. Conclusions. The results of the study show that viewing a film on HIV infection is an effective method of transferring knowledge about HIV to the Serbian military population.

  6. Armed forces career exploration for high school students in the fields of engineering and science. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Morgan State University`s School of Engineering conducted its third annual Armed Forces Career Exploration program for high school students in the fields of engineering and science. The four week program was jointly sponsored by the US Army Laboratory Command (Ballistics Research Laboratory and Human Engineering Laboratory) and US Department of Energy (Los Alamos National Laboratory). The environment in a predominantly urban school system is such that a significant number of very capable students reach the eleventh grade without plans for the future. These students as a result of teacher influence have taken lower level math and science courses and we feel by participating in this program will see reasons for pursuing higher level math and science courses their last two years in high school. Inasmuch as intervention programs have not yet significantly affected the profile of these schools this pool of students represents an opportunity to make an early impact on the number of students that enter college intending to major in math, science or engineering. This report presents the program that provided selected students with pre-engineering and science enrichment experiences designed to enhance their understanding of engineering, increase their awareness of career opportunities in science and engineering, advance their readiness to enter temporary job situation, and foster the development of self-confidence in their individual capabilities.

  7. Diagnostic and therapeutic approaches after suspected or confirmed extraordinary exposure to ionizing radiation of members of the German Armed Forces

    International Nuclear Information System (INIS)

    This report refers to the results of 5 working packages. The first of them deals in detail with 11 extraordinary radiation accidents resulting in a chronic or protracted/intermittent radiation exposure. In most of the cases, the radiation etiology of observed health impairments was suspected many days, weeks or months after the beginning of accidental exposure. Therefore, in the second package, a review of results of systematic chronic radiation exposures in dogs, rats and mice was done to try to understand the pathophysiology of observations in man. The key problem lies in the day-by-day radiation effects on hemopoietic stem cells and their capability to cope with the radiation induced excess cell loss. On this basis, diagnostic approaches to assess the functional potentials of cell renewal are outlined in package 3. These considerations lead to therapeutic recommendations (package 4): in case of an irreversible damage to the stem cell pool, a stem cell transplantation may be the only way to induce recovery. In case of a reversible damage, the transient hemopoietic failure can be bridged by appropriate supportive measures to prevent infection or bleeding. The package 5 recommends to initiation of continuing medical education for the Armed Forces Medical Services to deal with this type of extraordinary radiation accidents which may occur in any 'out-of-area' - mission. (orig.)

  8. The arms race control

    International Nuclear Information System (INIS)

    Written in 1961, this paper presents the content of a book entitled 'The arms race control' where the author outlined the difference between disarmament and arms control, described the economic and moral role of arms race, the importance of force balance for international security. He wandered whether arms control could ensure this balance and whether nuclear balance meant force balance. Force balance then appears to be a precarious and unsteady component of international security. He commented the challenges of disarmament, recalled some arguments for a nuclear disarmament. Then he discussed what would be an arms control with or without disarmament (either nuclear or conventional)

  9. National Radiobiology Archives distributed access programmer's guide

    International Nuclear Information System (INIS)

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of the software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives

  10. STRATEGIC KNOWLEDGE MANAGEMENT IN THE ARMED FORCES ACADEMY OF GENERAL M. R. ŠTEFÁNIK IN LIPTOVSKÝ MIKULÁŠ, THE SLOVAK REPUBLIC

    OpenAIRE

    Mária PETRUFOVÁ

    2015-01-01

    The article stresses the importance of strategic knowledge management in the era of global competition. Strategic knowledge management raises the demand for permanent learning stressing the visions and personal aspirations of everyone within the modern effi cient organisation. Within the AFA of General M.R. Štefánik and, inherently, in the Armed Forces of the Slovak Republic, strategic knowledge management employs and implements knowledge as the ultimate step in the knowledge pyramid.

  11. Employer attractiveness of the Swedish Armed Forces : A quantitative study of gender differences and the effects of employer brand attributes and social media in the government authority sector

    OpenAIRE

    Jorlöv, Karin; Venngren, Emma

    2014-01-01

    The main purpose of this degree project has been to examine the effects of employer brand attributes and activities on social media to the employer attractiveness of the Swedish Armed Forces. We aimed to make theoretical contributions to the fields of employer branding and social media marketing, and test a unique conceptual model for the government authority. The conceptual model focuses on employer brand attributes that have previously been connected to employer attractiveness in this type ...

  12. Structural Sexual Violence in the Peruvian Military : An Empirical Study of Discrimination against Women and its consequences in the Peruvian Armed Forces

    OpenAIRE

    2010-01-01

    The aim of this thesis is the better understanding of structural sexual violence against women. Through a human rights approach, the author examines the link between the gendered discriminatory policies against women and the occurrences of sexual violence against female soldiers within the Peruvian Armed Forces. This empirical study demonstrates that whereas civil and political rights must be respected and enforced, the satisfaction of socio-economic rights is also a key element for the preve...

  13. Integration of gamma measuring equipment into an Agusta A109BA helicopter of the Belgian Armed Forces for use in emergency situations

    International Nuclear Information System (INIS)

    In case of a nuclear emergency, accidental releases of radioactive material might cause large scale environmental contamination. After the emergency has been brought under control, and the radioactive releases have settled on the ground, it is essential to map as quickly as possible the extent of the contaminated area and to evaluate the severity of the contamination. Airborne gamma measurements are known to be an effective means for quickly and safely mapping and evaluating large scale contaminations of gamma-emitting radio nuclides. We wanted to integrate gamma measuring equipment, based on a NaI detector, into an Agusta A109BA helicopter of the Belgian armed forces. This was done within the framework of ''Aid to the Nation'', a special program developed by the Belgian Armed Forces for facilitating cooperation between the armed forces and civilian organisations, for projects that are to the benefit of the Belgian Nation. Working in this framework, we also want to develop the necessary procedures that will allow quick and efficient deployment of the measuring capability in case of an emergency

  14. Evolution of radiobiological models in radiation oncology

    International Nuclear Information System (INIS)

    Predicting treatment outcome to radiotherapy from in-vitro radiobiological parameters and utilizing the BED approach helps to tailor individual patient treatments and design new promising treatment protocols for patients in whom unfavorable treatment outcome is anticipated. This paper presents the present status of the LQ model of dose effect relationship

  15. National Radiobiology Archives Distributed Access user's manual

    International Nuclear Information System (INIS)

    This User's Manual describes installation and use of the National Radiobiology Archives (NRA) Distributed Access package. The package consists of a distributed subset of information representative of the NRA databases and database access software which provide an introduction to the scope and style of the NRA Information Systems

  16. Soft x rays for radiobiological studies

    International Nuclear Information System (INIS)

    Lethal effects and chromosome aberrations induced in cells exposed to low energy (soft) X rays demonstrated that these relatively low energy X rays are just as effective as those of higher energy for radiobiological studies, and even more effective for irradiating cultured mammalian cells than laboratory animals. (author)

  17. Radiobiological and clinical aspects of neutron therapy

    International Nuclear Information System (INIS)

    Radiobiological investigations and their interpretation are discussed. The history of neutrontherapy, the results of RBE-investigations in man as well as clinical results are given. The hypothesis on reaction of human tissue and tumours towards neutron irradiation is presented. (A.S.)

  18. Force.

    Science.gov (United States)

    Gamble, Reed

    1989-01-01

    Discusses pupil misconceptions concerning forces. Summarizes some of Assessment of Performance Unit's findings on meaning of (1) force, (2) force and motion in one dimension and two dimensions, and (3) Newton's second law. (YP)

  19. The dental specialties related articles published in Medical Journal Armed Forces India from 2000 to 2014 over a 15-year period.

    Science.gov (United States)

    Shamim, Thorakkal

    2015-12-01

    There is a paucity of information about the dental specialties related articles published in the Medical Journal Armed Forces India (MJAFI). This study aimed to audit the dental specialities related articles published in MJAFI from 2000 to 2014 over a 15-year period. Bibliometric analysis of sixty issues of MJAFI from 2000 to 2014 were performed using web-based search. The articles published were analyzed for type of article and topic of individual dental specialities. The articles published were also evaluated to identify whether the study was an Armed Forces Medical Research Committee Project or funded research project or not. Out of the total 118 published articles related to dental specialities, original articles (55) and case reports (49) contribute the major share. The highest number of dental specialities related articles was published in 2009 with 16, followed by 2010 with 13 and 2011 with 11 and the least published year was 2013 with 3 articles. Regarding the relationship with dental specialities, the maximum number of published articles were related to oral medicine and radiology (56) followed by oral and maxillofacial surgery (49), orthodontics (23) and prosthodontics (17). Among the articles published in MJAFI, maxillofacial injuries (11) followed by orthodontic treatment (8) and craniofacial deformities (8) form the major attraction of the contributors. Among the 118 dental speciality articles, there were only 4 Armed Forces Medical Research Committee Project articles and 19 funded research project articles. An equal distribution of articles related to clinical dentistry and nonclinical dentistry is maintained for the MJAFI from 2000 to 2014 over a 15-year period. PMID:26858474

  20. Self-Rated Health and its Relationship to Health/Life Problems and Coping Strategies in Members of the Professional Slovenian Armed Forces

    OpenAIRE

    Selic, Polona; Petek, Davorina; Serec, Masa; Rus Makovec, Maja

    2012-01-01

    The aim of this study was to test the association between self-rated health status (i.e. psychological and interpersonal welfare, physical health, coping mechanisms) and absence from work due to illness in the Slovenian armed forces. 390 military personnel were included in the study. Two groups of soldiers, healthy (G1-H) and sick/less healthy (G2-S), were created according to the median value of their annual sick leave. A third group consisted of soldiers on a mission (G3-M). A background qu...

  1. Workshop on radiobiological effectiveness of neutrons

    International Nuclear Information System (INIS)

    The radiobiological effectiveness (RBE) of neutrons has become the subject of some heated discussions in both scientific and radiation-protection oriented communities. This has become especially so since the realization that neutron exposures of A-bomb survivors in Hiroshima were considerably lower than previously assumed, thus ''devaluating'' the importance of what we thought was a solid human data base. At the same time, more recent data from radiobiological research appeared to indicate that, at least for some biological endpoints, the RBE of neutrons at low doses and low dose rates was increased dramatically compared to the RBE at higher dose and dose rates. As a consequence, the protection of health against neutrons became a subject of some urgency. The objective of this workshop was to evaluate the existing data base in order to determine the need for additional research in this field. 22 refs., 3 figs., 6 tabs

  2. The Fundamentals of Imaging Physics and Radiobiology

    CERN Document Server

    Selman, Joseph

    2000-01-01

    Like its well-known predecessor, this new and expanded Ninth Edition presents numerous important changes, beginning with the title and continuing throughout the text. Drawing on current knowledge and his own extensive experience, Dr. Selman provides a thorough revision and overview of each previously included chapter. Definitions, foundations, and principles are presented along with changes in methods and procedures. The text presents five new chapters on computed tomography, radioactivity and diagnostic nuclear medicine, radiobiology, protection in radiology/health physics, and nonradiologic

  3. Scientific projection paper for space radiobiological research

    International Nuclear Information System (INIS)

    A nationale for the radiobiological research requirements for space is rooted in a national commitment to the exploration of space, mandated in the form of the National Space Act. This research is almost entirely centered on man; more specifically, on the effects of the space radiation environment on man and his protection from them. The research needs discussed in this presentation include the space radiation environment; dosimetry; radiation biology-high LET particles (dose/response); and operational countermeasures

  4. Radiobiological models of normal tissue reactions

    International Nuclear Information System (INIS)

    Purpose: The present review summarizes radiobiological models of normal tissue responses to radiation and their consequences for potential therapeutic interventions. Material and Methods: Common radiobiological principles and pathogenetic models can be established for classes of tissues. These models may support the development of general modalities, both therapeutic and supportive, for the modulation of these responses. Results: The stem cell concept, based on studies in standard tissue culture, describes the clonogenic survival after radiation treatment. The factors affecting cell survival are summarized as the 4 Rs of radiotherapy. Based on the stem cell concept, the reactions of normal tissue to ionising radiation were considered a consequence exclusively of the proliferative sterilisation of cells of a given target cell population. Once stem cells are inactivated, responses develop in a passive manner. However, recent studies into the pathogenesis of radiation tissue injury have clearly shown that numerous postirradiation events occur during the symptom-free latent time in irradiated cells and tissues, which modulate the manifestation of damage. These are summarized by models of tissue radiation pathology. Conclusions: Cellular radiobiology and the tissue models based on the stem cell concept assume that exclusively the sterilisation of target cells is the radiation effect which results in both acute and late tissue responses. As a consequence, the radiation sensitivity can only be modulated by modification of radiobiological parameters at the time of irradiation, while at later time points only symptomatic treatment can be applied. Tissue radiation pathology, in contrast, allows for post-irradiation modification of the manifestation of radiation sequelae in tissues. (orig.)

  5. Dosimetry for radiobiology experiments at GANIL

    Science.gov (United States)

    Durantel, Florent; Balanzat, Emmanuel; Cassimi, Amine; Chevalier, François; Ngono-Ravache, Yvette; Madi, Toiammou; Poully, Jean-Christophe; Ramillon, Jean-Marc; Rothard, Hermann; Ropars, Frédéric; Schwob, Lucas; Testard, Isabelle; Saintigny, Yannick

    2016-04-01

    Mainly encouraged by the increasing application of ion beams for cancer treatment (hadron-therapy) including carbon beams, the use of heavy ion facilities for radiobiology is expanding rapidly today. As an alternative to dedicated centers for treatment and medical research, accelerators like GANIL offer the possibility to undertake such experiments. Since 20 years, CIMAP, reinforced 15 years ago by the biological host laboratory LARIA, has been receiving researchers in radiobiology and assisted them in performing experiments in different fields such as hadron-therapy, space radioprotection and fundamental biological and physico-chemical mechanisms. We present here a short description of the beam line and the on-line equipments that allow the automatic irradiation of up to 24 biological samples at once. We also developed an original on-line beam monitoring procedure for low ion flux (low dose rates) based on the measurement of the K-shell X-rays emitted from a thin iron foil. This detector is calibrated on an absolute scale before each experiment by counting etched tracks on an irradiated CR39 polymer plate. We present the performances and limits of this method and finally give typical fluence (dose) uncertainties for a standard irradiation in radiobiology.

  6. Particle beam therapy for cancer. A radiobiological perspective

    International Nuclear Information System (INIS)

    As for the particle beam therapy, there is to theoretical evidence by radiobiology. The particle beam therapy becomes high precision by development of the medicine engineering. We demonstrated the past contribution for the particle beam therapy and recent knowledge about radiobiological phenomenon such as (1) DNA damage and the repair, (2) cell killing effect, (3) metastasis, and (4) therapeutic gain. Finally, we discuss it about the radiobiological perspective for the particle beam therapy. (author)

  7. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings

    International Nuclear Information System (INIS)

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  8. 美军联合电子战消除频率冲突方式%Method to Eliminate Electronic Warfare Electromagnetic Frequencies Conflicts by US Armed Force

    Institute of Scientific and Technical Information of China (English)

    陈邓安; 丛中旖; 吴杰

    2012-01-01

    为在作战、通信和情报活动中协调地使用电磁频谱,对美军联合电子战消除频率冲突的方式进行研究.研究美军联合电子战消除频率冲突的程序和内容,介绍美军在联合电子战中分析频率冲突的2种方式,并分析美军联合部队各相关部门的职责.该研究可为提升我军电子战水平提供参考.%Under battle, communication and intelligence activity, in order to make good use of the electromagnetic spectrum, research the method to eliminate the electromagnetic frequencies conflicts by US armed force. Study the procedure of the US armed force dealing with electromagnetic frequencies conflicts, introduce the methods to analysis electromagnetic frequencies conflicts, and analysis the responsibility of the relevant departments, which can provides active reference for the coordination in the joint operations.

  9. The Canadian Armed Forces “YouTube War”: A Cross-Border Military-Social Media Complex

    OpenAIRE

    Tanner Mirrlees

    2015-01-01

    The goal of this paper is to conceptualize, contextualize, and critically analyze the Canadian Armed Forces’ (CAF) use of YouTube to promote itself, recruit soldiers, and frame its role in the post-9/11 U.S.-led NATO war in Afghanistan. The first section of this paper engages with scholarship on war and the media, the military-industrial-communications complex (MICC), and YouTube War to conceptualize YouTube as a tool and contested battle-space of 21st century new media wars. The second secti...

  10. Radiation monitoring considerations for radiobiology facilities

    International Nuclear Information System (INIS)

    Battelle, Pacific Northwest Laboratories, conducts a wide variety of radiobiology and radioecology research in a number of facilities on the Hanford Reservation. Review of radiation monitoring problems associated with storage, plant and animal experiments, waste handling and sterile facilities shows that careful monitoring, strict procedural controls and innovative techniques are required to minimize occupational exposure and control contamination. Although a wide variety of radioactivity levels are involved, much of the work is with extremely low level materials. Monitoring low level work is mundane and often impractical but cannot be ignored in today's ever tightening controls

  11. Radiobiological studies using gamma and x rays.

    Energy Technology Data Exchange (ETDEWEB)

    Potter, Charles Augustus; Longley, Susan W.; Scott, Bobby R. [Lovelace Respiratory Research Institute, Albuquerque, NM; Lin, Yong [Lovelace Respiratory Research Institute, Albuquerque, NM; Wilder, Julie [Lovelace Respiratory Research Institute, Albuquerque, NM; Hutt, Julie A. [Lovelace Respiratory Research Institute, Albuquerque, NM; Padilla, Mabel T. [Lovelace Respiratory Research Institute, Albuquerque, NM; Gott, Katherine M. [Lovelace Respiratory Research Institute, Albuquerque, NM

    2013-02-01

    There are approximately 500 self-shielded research irradiators used in various facilities throughout the U.S. These facilities use radioactive sources containing either 137Cs or 60Co for a variety of biological investigations. A report from the National Academy of Sciences[1] described the issues with security of particular radiation sources and the desire for their replacement. The participants in this effort prepared two peer-reviewed publications to document the results of radiobiological studies performed using photons from 320-kV x rays and 137Cs on cell cultures and mice. The effectiveness of X rays was shown to vary with cell type.

  12. Physics and radiobiology of nuclear medicine

    CERN Document Server

    Saha, Gopal B

    2010-01-01

    From a distinguished author comes this new edition for technologists, practitioners, residents, and students in radiology and nuclear medicine. Encompassing major topics in nuclear medicine from the basic physics of radioactive decay to instrumentation and radiobiology, it is an ideal review for Board and Registry examinations. The material is well organized and written with clarity. The book is supplemented with tables and illustrations throughout. It provides a quick reference book that is concise but comprehensive, and offers a complete discussion of topics for the nuclear medicine and radi

  13. New developments in fundamental and applied radiobiology

    International Nuclear Information System (INIS)

    The 23rd Annual Meeting of the European Society for Radiation Biology was held in Dublin, Eire, 23-26 September 1990. Papers presented were grouped into two themes:- (a) Promoting areas where new developments in cell and molecular biology are fundamentally altering concepts of radiation action (papers on radiation induced mutagenesis and transformations, dosimetry and risk, DNA damage and repair, low dose/low dose rate effects, and non-ionising radiation). (b) Areas where radiobiological information is directly important to the topic (papers on food irradiation, diagnostic imaging, environmental radiation, radiotherapy, and the oxygen effect). (UK)

  14. Generalized calculus in radiobiology: Physical implications

    CERN Document Server

    Sotolongo-Grau, O; Antoranz, J C; Sotolongo-Costa, Oscar

    2009-01-01

    Non-extensive statistical physics has allowed to generalize mathematical functions such as exponential and logarithms. The same framework is used to generalize sum and product so that the operations allow a more fluid way to work with mathematical expressions emerging from non-additive formulation of statistical physics. In this work we employ the generalization of the exponential, logarithm and product to obtain a formula for the survival fraction corresponding to the application of several radiation doses on a living tissue. Also we provide experimental recommendations to determine the universal characteristics of living tissues in interaction with radiation. These results have a potential application in radiobiology and radiation oncology.

  15. Automobile or Other Conveyance and Adaptive Equipment Certificate of Eligibility for Veterans or Members of the Armed Forces With Amyotrophic Lateral Sclerosis Connected to Military Service. Final rule.

    Science.gov (United States)

    2016-01-13

    The Department of Veterans Affairs (VA) published an Interim Final Rule on February 25, 2015, to amend its adjudication regulations to provide a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment for all veterans with service-connected amyotrophic lateral sclerosis (ALS) and servicemembers serving on active duty with ALS. The amendment authorized automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected ALS and members of the Armed Forces serving on active duty with ALS. The intent of this final rule is to confirm the amendment made by the interim final rule without change. PMID:26761955

  16. The Freedom of Expression of Members of the Armed Forces Under the European Convention on Human Rights In Jokšas V. Lithuania

    Directory of Open Access Journals (Sweden)

    Kirchner Stefan

    2014-06-01

    Full Text Available Freedom of expression is one of the most fundamental rights in a democratic society. In fact, the freedom to express one’s opinion and to impart, as well as to receive, information, is essential for the participation in the democratic process. The ability to make decisions as a citizen requires access to information; the participation in the life of the society requires the ability to express one’s opinions. It is imperative that in a democratic society, as it is envisaged by the European Convention on Human Rights (ECHR, everybody is able to express their views, regardless as to whether these views correspond to the views of those who are in power. This ability is one of the key differences between democracy anddictatorship. In particular in the nation-states of Eastern Europe, which have only known freedom for a bit less than a quarter of a century, the growth of democratic structures is inextricably linked to the ability to exercise this right. But while human rights in principle pit the citizen against the State, the citizen who serves the State in a professional function might also wish to express opinions that go against the view of those who are entrusted with leading the State. This is particularly the case when it comes to members of the armed forces. The jurisprudence of the Convention organs with regard to the right of public officials and other State agents to express their opinion freely is not as coherent as it is with regard to other questions concerning the ECHR. In a case decided in late 2013, the European Court of Human Rights dealt with this question with regard to Lithuania. In this article, the authors look at the question of how far the State can restrict the freedom of expression of members of the armed forces under the European Convention on Human Rights.

  17. Assessment of Ration Scales of the Armed Forces Personnel in Meeting theNutritional Needs at Plains and High Altitudes–I

    Directory of Open Access Journals (Sweden)

    S.T Babusha

    2008-11-01

    Full Text Available Adequate nutrition is very essential, especially for the Armed Forces, to buildup their nutritional reserveswhile deriving maximum benefits of training/peak performances in operational situations by keeping theirmorale high. The present study reviews/examines the adequacy of the existing ration scales of the ArmedForces personnel stationed under different terrain conditions of the country/recruits at various training centres.Food samples were collected from different strategic locations during different seasons of the year and analysedfor their nutrient composition like proximal constituents, vitamins A, E, B1, B2, C, and dietary fibre. Basedon the data generated, the daily nutrients/energy consumption by the soldiers/recruits, were calculated separatelyboth for personnel in plains and at high altitudes. Soldiers in plains, on an average consumed protein 124.2+ 13.0 g, fat 98.8 + 29.6 g and energy 3632+317 kcal/person/day, while their counterparts at high altitudesconsumed protein 120.4 + 11.2 g, fat 120.1 + 31.1 g, and energy 3906 + 423 kcal/person/day. The study clearlyindicate that the present ration scales for the Service personnel, both in plains and at high altitudes (9000 ftto 15000 ft is adequate wrt their nutrient density. It is however suggested to ensure adequate supply of goodquality fresh vegetables, fruits, and meat, which inturn would not only help to keep the morale of the soldiers,high and cheerful, especially at high altitudes, but will also enable adequate micronutrient availability. Thefibre levels in the diets of these soldiers have also been found to be well within the limits (20 -35 g/ person/day recommended for optimal health.Defence Science Journal, 2008, 58(6, pp.734-744, DOI:http://dx.doi.org/10.14429/dsj.58.1701

  18. Branched chain amino acids improve radial-arm maze acquisition and water maze forced-choice learning in rat offspring exposed in utero to hyperphenylalaninemia.

    Science.gov (United States)

    Vorhees, C V; Acuff-Smith, K D; Weisenburger, W P; Minck, D R; Berry, H K

    1992-01-01

    Maternal phenylketonuria results in a high incidence of children born mentally retarded. We showed that the large neutral amino acids valine, isoleucine, and leucine (VIL) ameliorate the effects of intrauterine hyperphenylalaninemia in rats on a test of complex maze learning. To further test the ameliorative effects of VIL on intrauterine CNS development during hyperphenylalaninemia, gravid rats were administered a phenylalanine/p-chlorophenylalanine (index group) supplemented diet with or without VIL added. Controls were given standard diet with or without VIL. All groups were pair-fed to the index group. As adults, the progeny exposed in utero to hyperphenylalaninemia showed characteristic learning impairments in a complex water (Cincinnati) maze on forced and elective-choice phases of the task and deficits in radial-arm maze and Morris maze acquisition, whereas those exposed to hyperphenylalaninemia combined with VIL showed no deficits in the forced-choice phase of Cincinnati maze learning and no evidence of radial-arm maze deficits. However, the improvement was not complete, with no ameliorative effects obtained on the elective-choice phase of the Cincinnati maze or on the Morris hidden platform test. No deficits were seen on phases containing test trials for memory function (Olton and Morris mazes). The acquisition differences occurred in the absence of any effects of VIL on maternal weight gain during gestation, maternal serum amino acid concentrations of phenylalanine or tyrosine, or effects on offspring growth. VIL alone produced no adverse or enhancing effects on learning or memory. Based on these data it was concluded that the VIL supplement continues to show promise as a potential treatment for intrauterinely acquired mental deficiency associated with maternal phenylketonuria. PMID:1593977

  19. Melanomas: radiobiology and role of radiation therapy

    International Nuclear Information System (INIS)

    Purpose/Objective: This course will review the radiobiology of malignant melanoma (MM) and the clinical use of radiation therapy for metastatic melanoma and selected primary sites. The course will emphasize the scientific principles underlying the clinical treatment of MM. Introduction: The incidence of malignant melanoma has one of the fastest growth rates in the world. In 1991, there were 32,000 cases and 7,000 deaths from MM in the United States. By the year 2000, one of every 90 Americans will develop MM. Wide local excision is the treatment of choice for Stage I-II cutaneous MM. Five-year survival rates depend on (a) sex: female-63%, male-40%; (b) tumor thickness: t 4 mm-25%; (c) location: extremity-60%, trunk-41%; and (d) regional lymph node status: negative-77%, positive-31%. Despite adequate surgery, 45-50% of all MM patients will develop metastatic disease. Radiobiology: Both the multi-target model: S = 1-(1-e-D/Do)n and the linear quadratic mode: -In(S) = alpha x D + beta x D2 predict a possible benefit for high dose per fraction (> 400 cGy) radiation therapy for some MM cell lines. The extrapolation number (n) varies from 1-100 for MM compared to other mammalian cells with n=2-4. The alpha/beta ratios for a variety of MM cell lines vary from 1 to 33. Other radiobiologic factors (repair of potentially lethal damage, hypoxia, reoxygenation, and repopulation) predict a wide variety of clinical responses to different time-dose prescriptions including high dose per fraction (> 400 cGy), low dose per fraction (200-300 cGy), or b.i.d. therapy. Based on a review of the radiobiology of MM, no single therapeutic strategy emerges which could be expected to be successful for all tumors. Time-Dose Prescriptions: A review of the retrospective and prospective clinical trials evaluating various time-dose prescriptions for MM reveals: (1) MM is a radiosensitive tumor over a wide range of diverse time-dose prescriptions; and (2) The high clinical response rates to a

  20. The Social Media Policy of U.S. Armed Forces in the Information Security Perspective%美军在信息安全视野下利用社交媒体政策研究

    Institute of Scientific and Technical Information of China (English)

    周殷夏; 白文杰

    2012-01-01

    近年来,美军逐步调整社交媒体政策,重视发挥其在公共事务、家庭服务以及塑造军队形象中的独特功能。从信息安全的角度出发,在分析美军社交媒体政策发展变化及其内在动因的基础上,总结出美军运用社交媒体所采取的信息安全措施。%In recent years, the U. S. armed forces gradually adjust the social media policy to attach impor- tance of its unique features in public affairs, family services, as well as shaping the image of the Armed Forces. From the perspective of information security, this article on the basis of the analysis of the U. S. armed forces social media policy development and changes in their intrinsic motivations, summed up the information security measures taken by the U.S. armed forces using social media.

  1. Department of Defense Authorization for appropriations for fiscal years 1988 and 1989. Hearings before the Committee on Armed Services, United States Senate, One Hundredth Congress, First Session on S. 1174, Part 4, Strategic Forces and Nuclear Deterrence

    International Nuclear Information System (INIS)

    Government, academic and military officials provided statements and documents in regard to S. 1174 authorizing appropriations for military activities of the Department of Defense and Department of Energy for defense activities. Strategic Forces and Nuclear deterrence categories include the following major topics: (1) Nuclear Testing Limitations, (2) Strategic Warning Capabilities and ICMB modernization, (3) Strategic Policy and Arms Control, and (4) Strategic Defense Initiatives

  2. BNL ACCELERATOR-BASED RADIOBIOLOGY FACILITIES

    Energy Technology Data Exchange (ETDEWEB)

    LOWENSTEIN,D.I.

    2000-05-28

    For the past several years, the Alternating Gradient Synchrotron (AGS) at Brookhaven National Laboratory (USA) has provided ions of iron, silicon and gold, at energies from 600 MeV/nucleon to 10 GeV/nucleon, for the US National Aeronautics and Space Administration (NASA) radiobiology research program. NASA has recently funded the construction of a new dedicated ion facility, the Booster Applications Facility (BAF). The Booster synchrotron will supply ion beams ranging from protons to gold, in an energy range from 40--3,000 MeV/nucleon with maximum beam intensities of 10{sup 10} to 10{sup 11} ions per pulse. The BAF Project is described and the future AGS and BAF operation plans are presented.

  3. Physics and radiobiology of nuclear medicine

    CERN Document Server

    Saha, Gopal B

    2013-01-01

    The Fourth Edition of Dr. Gopal B. Saha’s Physics and Radiobiology of Nuclear Medicine was prompted by the need to provide up-to-date information to keep pace with the perpetual growth and improvement in the instrumentation and techniques employed in nuclear medicine since the last edition published in 2006. Like previous editions, the book is intended for radiology and nuclear medicine residents to prepare for the American Board of Nuclear Medicine, American Board of Radiology, and American Board of Science in Nuclear Medicine examinations, all of which require a strong physics background. Additionally, the book will serve as a textbook on nuclear medicine physics for nuclear medicine technologists taking the Nuclear Medicine Technology Certification Board examination.

  4. Basics of radiobiology and nuclear medicine

    International Nuclear Information System (INIS)

    The authors successively reveal the topics of the biological impact of radiation (radiobiology) and the diagnostic and the therapeutic application of radiopharmaceuticals (nuclear medicine). Data on the influence of radiation on subcellular, cellular, tissue and organ level are given, on early and late radiation changes, as well. Indication for the application of the different radionuclide methods in the diagnosis of the diseases in the endocrinology, nephrology, cardiology, gastroenterology, haematology of lungs, bones, tumors are pointed out and the main trends of the growing therapeutical use of nuclear medicine are presented. The aim is to teach students the nuclear medicine methods in the complex investigation of the patients, his preliminary preparation and the biological impact of radiation and its risk. Self assessment test for students are proposed and a literature for further reading

  5. Radiobiological characteristic of tritium-labelled lysine

    International Nuclear Information System (INIS)

    Experiments on mice and rats injected with tritium-labeled lysine have revealed that one day after injection about 80% of the label was retained in organs and tissues as tissue-bound tritium. Retention curves for tritium in the body were decomposed into two exponentials. The biological half-lives of tritium-labeled lysine in various tissues exceed half-lives of other tritiated amino acids and of triated water. The average dose in different tissues following injection of tritiated lysine exceeds that from equal of tritium oxide (THO) by 1.5-8 times. Contribution of the tissue-bound tritium in dose is about 90%. radiobiological experiments showed strong genetic and citotoxic effects in male mice after injection of tritium-labeled lysine

  6. Harmonization of radiobiological assays: why and how?

    International Nuclear Information System (INIS)

    The International Atomic Energy Agency has made available a technical manual for cytogenetic biodosimetry assays (dicentric chromosome aberration (DCA) and cytokinesis-block micronucleus (CBMN) assays) used for radiation dose assessment in radiation accidents. The International Standardization Organization, which develops standards and guidelines, also provides an avenue for laboratory accreditation, has developed guidelines and recommendations for performing cytogenetic biodosimetry assays. Harmonization of DCA and CBMN assays, has improved their accuracy. Double-blinded inter-laboratory comparison studies involving several networks have further validated DCA and CBMN assays and improved the confidence in their potential use for radiation dose assessment in mass casualties. This kind of international harmonization is lacking for pre-clinical radiobiology assays. The widely used pre-clinical assays that are relatively important to set stage for clinical trials include clonogenic assays, flow-cytometry assays, apoptotic assays, and tumor regression and growth delay assays. However, significant inter-laboratory variations occur with respect to data among laboratories. This raises concerns on the reliability and reproducibility of preclinical data that drives further development and translation. Lack of reproducibility may stem from a variety of factors such as poor scientist training, less than optimal experimental design, inadequate description of methodology, and impulse to publish only the positive data etc. Availability of technical manuals, standard operating procedures, accreditation avenues for laboratories performing such assays, inter-laboratory comparisons, and use of standardized protocols are necessary to enhance reliability and reproducibility. Thus, it is important that radiobiological assays are harmonized for laboratory protocols to ensure successful translation of pre-clinical research on radiation effect modulators to help design clinic trials with

  7. Post-refractive surgery complications and eye disease, active component, U.S. Armed Forces, 2005-2014.

    Science.gov (United States)

    Blitz, Jason B; Hunt, Devin J; Cost, Angelia A

    2016-05-01

    Refractive surgery (RS) is a common procedure in the U.S. military population. This report provides an estimation of incident RS for vision correction purposes in the active component of the U.S. military from 1 January 2005 through 31 December 2014 and the prevalence of post-RS complications and eye disease in the 1-year period after RS. During the surveillance period, a total of 121,571 subjects without a diagnosis of eye disease other than hyperopia, myopia, or astigmatism in the previous year received a single incident RS procedure. In the 1-year period after RS, 5.3% of subjects with preoperative hyperopia or myopia had treatment-persistent (unresolved) hyperopia or myopia; 2.0% of subjects with preoperative astigmatism had treatment-persistent (unresolved) astigmatism; and 3.8% were diagnosed with tear film insufficiency. In general, most outcomes showed higher prevalences in Army and Air Force personnel versus Navy and Marine Corps personnel, in women versus men, in officer versus enlisted personnel, and in aviation and Special Forces personnel. A wide variation in outcome prevalences was noted by procedural military treatment facility. PMID:27255946

  8. Radiobiology with heavy charged particles: a historical review

    Energy Technology Data Exchange (ETDEWEB)

    Skarsgard, L.D. [Dept. of Medical Biophysics, B.C. Cancer Research Centre and TRIUMF, Vancouver (Canada)

    1997-09-01

    The presentation will attempt to briefly review some of radiobiological data on the effects of heavy charged particles and to discuss the influence of those studies on the clinical application which followed. (orig./MG)

  9. Radiobiology of Radiosurgery for the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Antonio Santacroce

    2013-01-01

    Full Text Available According to Leksell radiosurgery is defined as “the delivery of a single, high dose of irradiation to a small and critically located intracranial volume through the intact skull.” Before its birth in the early 60s and its introduction in clinical therapeutic protocols in late the 80s dose application in radiation therapy of the brain for benign and malignant lesions was based on the administration of cumulative dose into a variable number of fractions. The rationale of dose fractionation is to lessen the risk of injury of normal tissue surrounding the target volume. Radiobiological studies of cell culture lines of malignant tumors and clinical experience with patients treated with conventional fractionated radiotherapy helped establishing this radiobiological principle. Radiosurgery provides a single high dose of radiation which translates into a specific toxic radiobiological response. Radiobiological investigations to study the effect of high dose focused radiation on the central nervous system began in late the 50s. It is well known currently that radiobiological principles applied for dose fractionation are not reproducible when single high dose of ionizing radiation is delivered. A review of the literature about radiobiology of radiosurgery for the central nervous system is presented.

  10. Viral Hepatitis in Iranian Armed Forces: Prevalence of HBV and HCV in the Wounded-In-Action (WIA

    Directory of Open Access Journals (Sweden)

    Reza Yousefi-Arfaee

    2005-12-01

    Full Text Available Objective: Viral hepatitis remains a health threat to military forces. Most recently there has been concern abouthepatitis C virus transmission during military service. Hepatitis B and C are the main causes of mortality and morbidity in military personnel. Methods: In this study, all WIAs of two corps of Revolutionary Guards of IR. Iran were checked for hepatitis B and C and liver function tests (LFT. A questionnaire was filled out for all WIAs, in which risk factors were asked.Results: In this study, 563 WIAs were enrolled. Mean age was 38.9±3.9. Mean rate of disability was 25.5%. HBsAg positive prevalence was 4.8% and anti-HCV was 0.7%. In anti-HCV positive group, 50% had elevated enzymes and in HBsAg positive WIAs, 30.4% had elevated enzymes. All of HCV positive WIAs had surgery as a risk factor (100%. Conclusions: Based on the prevalence of anti-HCV positive, which shows a 5.5 times increase in prevalence of HCV in our study group, we recommend HCV infection screening in WIAs.

  11. The European Radiobiology Archives (ERA), its present status, relation to other radiobiology archives and future development

    International Nuclear Information System (INIS)

    The European Radiobiology Archives (ERA) in cooperation with the US (National Radiobiology Archives, NRA) and Japanese (Japanese Radiobiology Archives, JRA) aim to collect most of the information still available in Europe on long-term animal experiments - including some selected human studies suitable for comparison with animal data - and to make them available to the scientific community for further analysis. Presently, the archives contain a description of the exposure conditions, animal strains, etc from ∝350.000 individuals, and data on survival and pathology are available from ∝200.000 individuals. These data are incorporated in an ACCESS 2000 database, which also includes means (forms with underlying computer code) for browsing through the data, searching for groups given certain treatments, using specific animal strains or age, etc. Other forms allow the selection of experimental groups, their evaluation by some statistical programs and their export for further detailed studies by interested scientists. The forms also allow researchers to combine groups and to pool diseases into larger classes, e.g. all malignant tumours, all lung tumours etc., features that are important when studies from different laboratories are to be evaluated. The use of the database is illustrated by an example on the selection and preparation for further analysis of data dealing with the effects of 224Ra. The collection of data will continue in the future; and the archives will liase with similar ventures such as the European 'pathbase'. The user interface will be developed further for accessibility and user friendliness and be continuously adjusted to the current state of the art of hardware and software. The archives are to be transferred to the Bundesamt fuer Strahlenschutz (BfS), Neuherberg, Germany under the sponsorship of the European Commission and in collaboration with the European Late Effect Project Group (EULEP). (orig.)

  12. In vitro irradiation system for radiobiological experiments

    International Nuclear Information System (INIS)

    Although two-dimensional (2-D) monolayer cell cultures provide important information on basic tumor biology and radiobiology, they are not representative of the complexity of three-dimensional (3-D) solid tumors. In particular, new models reproducing clinical conditions as closely as possible are needed for radiobiological studies to provide information that can be translated from bench to bedside. We developed a novel system for the irradiation, under sterile conditions, of 3-D tumor spheroids, the in vitro model considered as a bridge between the complex architectural organization of in vivo tumors and the very simple one of in vitro monolayer cell cultures. The system exploits the same equipment as that used for patient treatments, without the need for dedicated and highly expensive instruments. To mimic the passage of radiation beams through human tissues before they reach the target tumor mass, 96-multiwell plates containing the multicellular tumor spheroids (MCTS) are inserted into a custom-built phantom made of plexiglass, the material most similar to water, the main component of human tissue. The system was used to irradiate CAEP- and A549-derived MCTS, pre-treated or not with 20 μM cisplatin, with a dose of 20 Gy delivered in one session. We also tested the same treatment schemes on monolayer CAEP and A549 cells. Our preliminary results indicated a significant increment in radiotoxicity 20 days after the end of irradiation in the CAEP spheroids pre-treated with cisplatin compared to those treated with cisplatin or irradiation alone. Conversely, the effect of the radio- chemotherapy combination in A549-derived MCTS was similar to that induced by cisplatin or irradiation alone. Finally, the 20 Gy dose did not affect cell survival in monolayer CAEP and A549 cells, whereas cisplatin or cisplatin plus radiation caused 100% cell death, regardless of the type of cell line used. We set up a system for the irradiation, under sterile conditions, of tumor cells

  13. Experience of the air medical evacuation team of Serbian armed forces in the united nations mission in the Democratic Republic of Congo - deployment stress and psychological adaptation

    Directory of Open Access Journals (Sweden)

    Joković Danilo B.

    2016-01-01

    Full Text Available Background/Aim. Wars of the nineties in former Yugoslavia, Somalia, Rwanda imposed new tasks to the United Nations (UN forces, such as providing humanitarian aid, protection of civilians, peacekeeping, and in many instances providing armed enforcement of peace. The aim of this study was an observational analysis of Serbian participation in the UNs Mission in the Democratic Republic of Congo with the emphasis on stress and coping techniques. Methods. Serbian contribution in this mission dates back to April 2003 till the present days with a military contingent consisting of six members as a part of Air Medical Evacuation Team. The observed stressogenous factors acted before arrival to the mission area and in the mission area. In this paper we analysed ways to overcome them. Results. The productive ways of overwhelming stress used in this mission were: honesty and openness in interpersonal communications, dedication to work, maintaining discipline and order, strict following of appropriate regime of work, diet, rest and recreation; regular communication with family and organizing and participation in various social, cultural and sports manifestations. Conclusion. This analysis indicates that out of all the observed factors, the most important is appropriate selection of personnel.

  14. Role of pulsed electromagnetic therapy in the management of backache: a study conducted at armed forces institute of rehabilitation medicine, rawalpindi

    International Nuclear Information System (INIS)

    To determine the role of pulsed electromagnetic therapy in providing pain relief for backache. Study Design: This was a quasi experimental study. Place and Duration: This study was conducted at Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan from Jan 2012 to June 2012. Material and Methods: This study included 65 consecutive patients with backache. The pain was assessed on 11 points (0-10) Numeric Rating Scale (NRS) and patients with score = 1 were included in the study. Detailed history was obtained and examination was performed. All patients were subjected to pulsed electromagnetic therapy. The pain was assessed at first week, 2nd week, third week and six week after start of the pulsed electromagnetic therapy. Data was compiled and analysed using SPSS version 17. A p-value < 0.05 was considered as significant. Results: There was marked reduction in pain of patients with backache after treatment with pulsed electromagnetic therapy. Reduction in pain as calculated by the NRS (numeric rating scale) value after 1st week was 25.35% (p=0.002), after 2nd week was 43.66% (p=0.001), after 3rd week was 50.7% (p=0.001) and after 6 weeks was 71.83% (p=0.001). Conclusion: Pulsed electromagnetic therapy is very effective in relieving pain in patients with backache. (author)

  15. La odontología forense en las Fuerzas Armadas: Una asignatura pendiente Forensic dentistry in the Armed Forces: an unresolved matter

    Directory of Open Access Journals (Sweden)

    A. Bel Blesa

    2011-12-01

    Full Text Available La odontología forense es una disciplina que está abriéndose paso en nuestras Fuerzas Armadas en respuesta a necesidades derivadas de la participación de España en misiones internacionales y al cumplimiento de lo acordado en el marco de la OTAN. Aún queda mucho camino que recorrer en lo referente a la identificación humana. Se analiza la situación actual referente a la Ficha de Identificación Odontológica en vigor y propone un nuevo modelo más acorde a los estándares internacionales.Forensic dentistry is an emerging discipline in our Armed Forces that answers the needs derived from the Spanish participation in overseas deployments and NATO agreements. There is still much to be done as far as human identification is concerned. The current Dental Identification Card is evaluated and a new model more in accordance with international standards is proposed.

  16. 美军联合电子战消除频率冲突研究%Research on Electromagnetic Frequencies Conflicts for US Armed Force Electronic Warfare

    Institute of Scientific and Technical Information of China (English)

    陈邓安; 李冬; 吴杰

    2011-01-01

    Under the complicated electromagnetic environment, in view of the topic about dealing with the electromagnetic frequencies conflicts, this article expatiate the procedure of the US armed force dealing with electromagnetic frequencies conflicts and the responsibility of the relevant departments, and the methods of dealing with electromagnetic frequencies conflicts, and provides active reference for the coordination in the joint operations.%针对电子战中的频率冲突问题,研究了美军联合电子战消除频率冲突的程序和内容,系统阐述了美军联合部队各相关部门的职责,分析了美军在联合电子战中消除电子战频率冲突的方式,为我军在未来联合作战中解决电磁频率冲突的相关问题提供参考。

  17. Biophysical and biomathematical adventures in radiobiology

    International Nuclear Information System (INIS)

    Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing ''state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing ''hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone marrow to large doses of photon radiation, low rates of exposure should be better tolerated than high rates; and (3) for some types of radiation (e.g., alpha particles and fission neutrons), moderate doses delivered at a low rate may be more harmful than the same dose given at a high rate. 53 refs., 7 figs

  18. Radiobiological foundation of thermal neutron capture treatment

    International Nuclear Information System (INIS)

    Five radiobiological problems in thermal neutron capture treatment were considered on the basis of experimental data. As a result of an experiment of irradiation using thermal neutron generated by an atomic pile of Kyoto University, RBE of thermal neutron on cultured B-16 melanoma cells was determined to 2.43. Cultured B-16 melanoma cells did not recovered from sublethal damage when fractionated irradiation of thermal neutron was performed. To know additive effects of 10B-compounds, an amount of 10B-boric acid equivalent to 5 μg/ml of 10B was administered to culture medium for melanoma cells before the irradiation. As a result, Do values when 10B-boric acid was administered before irradiation were 3.3 times as much as those when only thermal neutron was irradiated, and RBE of thermal neutron when 10B-boric acid was administered was 3.04 RBE of 10B(n, α)7Li reaction (3.43) was also calculated. It was pointed out that it was difficult to estimate absorbed dose precisely by 10B(n, α)7Li reaction. It was also necessary to know the movement from proliferation to differentiation of cells accurately when neutron capture treatment using differential plasma of cancer cells was performed. (Tsunoda, M.)

  19. Expand and Implementation of the Armed Police Forces Telemedicine Network Platform%武警部队远程医学网络平台的拓展与实现

    Institute of Scientific and Technical Information of China (English)

    李颖; 张志荣; 王庆民

    2014-01-01

    Relying on the armed police forces has built wide area network, construction of telemedicine network platform, extend the armed police forces telemedicine network to the grass-roots Squadron. This article mainly elaborates the design and implementation process of network architecture, technical characteristics and problems.%依托武警部队已建成的广域网,构建远程医学网络平台,将武警部队远程医学网延伸到基层中队,重点对设计与实施过程中的网络架构、技术特点等问题进行了阐述。

  20. Toward a national consensus: teaching radiobiology to radiation oncology residents

    International Nuclear Information System (INIS)

    Purpose: The ASTRO Joint Working Group on Radiobiology Teaching, a committee composed of members having affiliations with several national radiation oncology and biology-related societies and organizations, commissioned a survey designed to address issues of manpower, curriculum standardization, and instructor feedback as they relate to resident training in radiation biology. Methods and Materials: Radiation biology instructors at U.S. radiation oncology training programs were identified and asked to respond to a comprehensive electronic questionnaire dealing with instructor educational background, radiation biology course content, and sources of feedback with respect to curriculum planning and resident performance on standardized radiation biology examinations. Results: Eighty-five radiation biology instructors were identified, representing 73 radiation oncology residency training programs. A total of 52 analyzable responses to the questionnaire were received, corresponding to a response rate of 61.2%. Conclusion: There is a decreasing supply of instructors qualified to teach classic, and to some extent, clinical, radiobiology to radiation oncology residents. Additionally, those instructors with classic training in radiobiology are less likely to be comfortable teaching cancer molecular biology or other topics in cancer biology. Thus, a gap exists in teaching the whole complement of cancer and radiobiology curricula, particularly in those programs in which the sole responsibility for teaching falls to one faculty member (50% of training programs are in this category). On average, the percentage of total teaching time devoted to classic radiobiology (50%), clinical radiobiology (30%), and molecular and cancer biology (20%) is appropriate, relative to the current makeup of the board examination. Nevertheless large variability exists between training programs with respect to the total number of contact hours per complete radiobiology course (ranging from

  1. Monte Carlo role in radiobiological modelling of radiotherapy outcomes

    Science.gov (United States)

    El Naqa, Issam; Pater, Piotr; Seuntjens, Jan

    2012-06-01

    Radiobiological models are essential components of modern radiotherapy. They are increasingly applied to optimize and evaluate the quality of different treatment planning modalities. They are frequently used in designing new radiotherapy clinical trials by estimating the expected therapeutic ratio of new protocols. In radiobiology, the therapeutic ratio is estimated from the expected gain in tumour control probability (TCP) to the risk of normal tissue complication probability (NTCP). However, estimates of TCP/NTCP are currently based on the deterministic and simplistic linear-quadratic formalism with limited prediction power when applied prospectively. Given the complex and stochastic nature of the physical, chemical and biological interactions associated with spatial and temporal radiation induced effects in living tissues, it is conjectured that methods based on Monte Carlo (MC) analysis may provide better estimates of TCP/NTCP for radiotherapy treatment planning and trial design. Indeed, over the past few decades, methods based on MC have demonstrated superior performance for accurate simulation of radiation transport, tumour growth and particle track structures; however, successful application of modelling radiobiological response and outcomes in radiotherapy is still hampered with several challenges. In this review, we provide an overview of some of the main techniques used in radiobiological modelling for radiotherapy, with focus on the MC role as a promising computational vehicle. We highlight the current challenges, issues and future potentials of the MC approach towards a comprehensive systems-based framework in radiobiological modelling for radiotherapy.

  2. Proceedings of the 4th Radiobiological conference with international participation 2008

    International Nuclear Information System (INIS)

    Scientific conference deals with problems in radiobiology, photobiology and radio-environmental sciences. The Conference included the following sessions: (i): Radiobiology; (ii) Biology. Proceedings contains thirty-two papers dealing with the scope of INIS

  3. 德国联邦国防军心理卫勤工作%Mental Health Service in German Federal Armed Forces

    Institute of Scientific and Technical Information of China (English)

    冯杰; 李晨; 刘柳; 郭树森; 张建杰

    2011-01-01

    德国联邦国防军历来重视军事作业过程的心理因素,以及军事人员心理问题和心理疾病的预防.德军心理卫勤工作严格依照该国相关法律法规,确立心理卫生人员的执业范围及资质,建立健全相应管理制度和督导体系,其研究工作科学、系统,尤其重视实战应用.这些做法为我军心理卫勤工作发展、人员教育培训及管理体系健全等方面提供有益借鉴和参考.%The psychological factors of military operations usually are focused by The German Federal Armed Forces, as well as the prevention of psychological problems and mental illness in military personnel. The mental health - care work is in strict accordance with the Germany laws and regulations in army. The practice scope and qualification in mental health staff are limited by German Psychological Association, including the management system and supervision system. The focus of psychological service in army is to promote the practical fighting capacity. The measures of German are the useful references of Chinese peoples Liberation Army in the logistic support of mental health, the education & training of psychological specialist, and the perfection of management - supervision system.

  4. Cardiomyopathies and the Armed Forces.

    Science.gov (United States)

    Holdsworth, D A; Cox, A T; Boos, C; Hardman, R; Sharma, S

    2015-09-01

    Cardiomyopathies are a group of heterogeneous myocardial diseases that are frequently inherited and are a recognised cause of premature sudden cardiac death in young individuals. Incomplete expressions of disease and the overlap with the physiological cardiac manifestations of regular intensive exercise create diagnostic challenges in young athletes and military recruits. Early identification is important because sudden death in the absence of prodromal symptoms is a common presentation, and there are several therapeutic strategies to minimise this risk. This paper examines the classification and clinical features of cardiomyopathies with specific reference to a military population and provides a detailed account of the optimum strategy for diagnosis, indications for specialist referral and specific guidance on the occupational significance of cardiomyopathy. A 27-year-old Lance Corporal Signaller presents to his Regimental medical officer (RMO) after feeling 'light-headed' following an 8 mile unloaded run. While waiting to see the RMO, the medical sergeant records a 12-lead ECG. The ECG is reviewed by the RMO immediately prior to the consultation and shows voltage criteria for left ventricular (LV) hypertrophy and inverted T-waves in II, III, aVF and V1-V3 (Figure 1). This Lance Corporal is a unit physical training instructor and engages in >10 h of aerobic exercise per week. He is a non-smoker and does not have any significant medical history. PMID:26246349

  5. National Radiobiology Archives distributed access programmer's guide

    Energy Technology Data Exchange (ETDEWEB)

    Prather, J. C. [Linfield Coll., McMinnville, OR (United States); Smith, S. K.; Watson, C. R. [Pacific Northwest Lab., Richland, WA (United States)

    1991-12-01

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of the software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives.

  6. Modern concepts for basic radiobiological factors characterizing tumor tissue radiosensitivity

    International Nuclear Information System (INIS)

    Traditionally radiotherapy is prescribed at doses consistent with the expected therapeutic response and tolerance of tumor and normal tissues without consideration to individual differences in radiosensitivity. However, the basic radiobiological knowledge and clinical experience along this line point to significant variations in the observed therapeutic results. It has been established that cells and tissues under experimental and clinical conditions manifest a wide spectrum of individual radiosensitivity. The aim of this survey is to outline the current concepts for the basic radiobiological factors influencing tumor radiosensitivity. A thorough discussion is done of the essence, mechanisms of action, methods of determination and measurement, and effect on the prognosis in patients with malignant diseases of a number of radiobiological factors, such as: tumor-cell proliferation, apoptosis, tumor hypoxia and neovascularization. Although the knowledge of the mechanisms of radiosensitivity is constantly expanding, its clinical implementation is still rather limited. The true role of radiosensitivity in predicting the therapeutic response should be more accurately defined. (authors)

  7. Report on the behalf of the Foreign Affairs, Defense and Armed Forces Commission on the bill project, adopted by the National Assembly, related to the struggle against the proliferation of arms of massive destruction and their vectors

    International Nuclear Information System (INIS)

    This report recalls the origins of the bill project which is the implementation of the UN Security Council resolution 1540, the aim of which was to promote the setting up of efficient tools to struggle against proliferation. The bill project aims at updating and reinforcing the existing law arsenal. The report also contains remarks made by the Commission. The bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  8. [Radiobiological aspects of diagnostic X-ray use in dentistry].

    Science.gov (United States)

    Hoogeveen, R C; van den Aardweg, G J M J

    2015-05-01

    Soon after the discovery of X-rays, it became clear that their use can cause detrimental effects. The field of radiobiology deals with these detrimental effects. In this article, the theoretical concepts of radiobiology relevant to diagnostic X-ray use are presented. The effects of radiation on living tissues, the relationship between dose and effect, and a translation of these effects into the dental application are discussed. X-rays cannot be considered to be harmless even when used at the relatively low doses as in dentistry. If applied with justification and optimization, the risk to the patient will, however, be small. PMID:26210221

  9. An Elastica Arm Scale

    CERN Document Server

    Bosi, F; Corso, F Dal; Bigoni, D

    2015-01-01

    The concept of 'deformable arm scale' (completely different from a traditional rigid arm balance) is theoretically introduced and experimentally validated. The idea is not intuitive, but is the result of nonlinear equilibrium kinematics of rods inducing configurational forces, so that deflection of the arms becomes necessary for the equilibrium, which would be impossible for a rigid system. In particular, the rigid arms of usual scales are replaced by a flexible elastic lamina, free of sliding in a frictionless and inclined sliding sleeve, which can reach a unique equilibrium configuration when two vertical dead loads are applied. Prototypes realized to demonstrate the feasibility of the system show a high accuracy in the measure of load within a certain range of use. It is finally shown that the presented results are strongly related to snaking of confined beams, with implications on locomotion of serpents, plumbing, and smart oil drilling.

  10. Influência da posição do braço na relação EMG-força em músculos do braço Influence of arm position on the EMG-force relationship in arm muscles

    Directory of Open Access Journals (Sweden)

    Anamaria Siriani de Oliveira

    2008-09-01

    Full Text Available A relação entre a amplitude do sinal eletromiográfico e a força muscular (EMG-força tem sido tomada como medida indireta da força muscular. Este estudo, em 18 voluntárias saudáveis e destras, visou avaliar a influência da posição do braço na relação EMG-força em músculos do braço em três tarefas - flexão do braço (FB, abdução do braço (AB e neutra do braço (NB - enquanto se tomavam ambas as medidas: uma célula de carga foi acoplada ao conversor do eletromiógrafo para registrar simultaneamente força e sinal eletromiográfico. Foram analisados os sinais dos músculos bíceps braquial, braquiorradial e tríceps braquial, e estimada a força de flexão e de extensão do braço nas diferentes tarefas. A relação entre esses conjuntos de valores foi analisada estatisticamente, verificando se havia correlação entre força e sinal eletromiográfico. Os resultados mostraram não haver tal correlação nas tarefas avaliadas. A posição do braço não influenciou a relação EMG-força dos músculos avaliados, com exceção do tríceps braquial, cuja atividade eletromiográfica foi maior durante a tarefa NB. Conclui-se que, em isometria, as tarefas podem ser empregadas para ativar o bíceps braquial e o braquiorradial; a tarefa NB é a mais indicada para ativar o tríceps braquial.The relationship between myoelectric signal amplitude and muscle strength (EMG-force has been used as an indirect measure of muscle strength. The aim of this study, in 18 healthy, female, right-handed volunteers, was to assess the influence of arm position on the relationship EMG-force of arm muscles in three different tasks: arm flexion, arm abduction, and neutral arm position. Both myoelectric signals and strength measures were acquired simultaneously, by coupling a load-cell to the electromyograph transducer. Signals from the biceps brachii, braquioradialis, and triceps brachii muscles were analysed, and arm extension and flexion force was

  11. New radiobiological, radiation risk and radiation protection paradigms

    International Nuclear Information System (INIS)

    The long-standing conventional paradigm for radiobiology has formed a logical basis for the standard paradigm for radiation risk of cancer and heritable effects and, from these paradigms, has developed the internationally applied system for radiation protection, but with many simplifications, assumptions and generalizations. A variety of additional radiobiological phenomena that do not conform to the standard paradigm for radiobiology may have potential implications for radiation risk and radiation protection. It is suggested, however, that the current state of knowledge is still insufficient for these phenomena, individually or collectively, to be formulated systematically into a new paradigm for radiobiology. Additionally, there is at present lack of direct evidence of their relevance to risk for human health, despite attractive hypotheses as to how they might be involved. Finally, it remains to be shown how incorporation of such phenomena into the paradigm for radiation protection would provide sufficient added value to offset disruption to the present widely applied system. Further research should aim for better mechanistic understanding of processes such as radiation-induced genomic instability (for all radiation types) and bystander effects (particularly for low-fluence high-LET particles) and also priority should be given to confirmation, or negation, of the relevance of the processes to human health risks from radiation.

  12. In vivo tumor radiobiology of heavy charged particles

    International Nuclear Information System (INIS)

    The response of tumor cells systems to irradiation with carbon, neon and argon beams at various positions in the plateau and extended-peak regions of the Bragg ionization curve is being evaluated from experiments conducted both in vivo and in vitro. The radiobiological end points being studied include: tumor volume response, cellular survival after tumor irradiation in situ, and cell-kinetic parameters

  13. Radiobiological researches on Dianthus caryophyllus L. carnation chimeras

    International Nuclear Information System (INIS)

    This research thesis reports a radiobiological study of Dianthus periclinal chimeras performed by submitting plants and plant cuttings at different physiological stages to cobalt-60 gamma irradiation under different dose conditions and rates. The effects of these treatments are studied while growing the so-processed plants and by microscopic examination of sections of irradiated meristems

  14. Biometrical analysis in radiobiological works of N.V. Luchnik

    International Nuclear Information System (INIS)

    The contribution of the famous Russian geneticist and biophysics N.V. Luchnik into biometrical analysis of radiobiological data is discussed. His works on radiation mortality of mice (2) and the process of post-radiation repair of chromosome aberrations (10) are thoroughly observed. The conclusion of necessity to develop biometrical analysis as separate part of biometry is made

  15. The ATM gene and the radiobiology of ataxia-telangiectasia

    International Nuclear Information System (INIS)

    Ataxia-telangiectasia (A-T) is the classic human genetic disease involving severe ionizing radiation sensitivity and as such has been intensely studied by radiation biologists over the years. Unlike its counterpart for UV light sensitivity -xeroderma pigmentosum - A-T has no obvious DNA repair defect; and there has been much speculation as to the mechanism underlying the altered radioresponses associated with this disease. The gene defective in A-T (ATM) has recently been cloned, and its primary coding sequence determined. The primary sequence of the ATM protein suggests that it has some regulatory functions related to cellular radioresponse and maintenance of genomic stability, and shares these functions with a growing family of other proteins in various organisms. At this juncture it is appropriate to review our current knowledge about the radiobiology of A-T and reflect on the possible radiobiological mechanisms that are suggested by the ATM gene itself. This article will attempt briefly to review current knowledge about the radiobiology of A-T and to introduce new speculations about underlying radiobiological mechanisms that are suggested by the primary amino acid sequence of the predicted ATM gene product. (Author)

  16. Research in radiobiology. Annual report, Internal Irradiation Program

    International Nuclear Information System (INIS)

    The annual progress report for the Radiobiology Division of the University of Utah College of Medicine is presented. Summaries of twenty-four projects concerning the metabolism, dosimetry and toxicity of a variety of actinide elements in beagles or rats are given. Individual papers within this report have been separately indexed and abstracted for the data base

  17. Tritium radiobiology research in the US DOE program

    International Nuclear Information System (INIS)

    The history of the original US Atomic Energy Commission, its replacement, the Energy Research and Development Administration, and the present Department of Energy's interest and sponsorship of tritium radiobiology is reviewed beginning in 1971 and continuing through 1986. In particular, the four remaining US Department of Energy, Division of Health and Environmental Research programs are described in some detail

  18. National Radiobiology Archives Distributed Access user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Watson, C.; Smith, S. (Pacific Northwest Lab., Richland, WA (United States)); Prather, J. (Linfield Coll., McMinnville, OR (United States))

    1991-11-01

    This User's Manual describes installation and use of the National Radiobiology Archives (NRA) Distributed Access package. The package consists of a distributed subset of information representative of the NRA databases and database access software which provide an introduction to the scope and style of the NRA Information Systems.

  19. Evidence for intermittent radiobiological hypoxia in experimental tumour systems

    International Nuclear Information System (INIS)

    This paper describes flow and static fluorescence cytometry techniques to visualize and quantitate acute radiobiological hypoxia resulting from transient fluctuation in tumour blood flow in experimental tumour systems. The application of these techniques in two murine tumour systems provides evidence that such hypoxia exists and reduces the effectiveness of single doses of radiation. Possible mechanisms for and implications of these findings are discussed. (author)

  20. Robotic arm

    Science.gov (United States)

    Kwech, Horst

    1989-04-18

    A robotic arm positionable within a nuclear vessel by access through a small diameter opening and having a mounting tube supported within the vessel and mounting a plurality of arm sections for movement lengthwise of the mounting tube as well as for movement out of a window provided in the wall of the mounting tube. An end effector, such as a grinding head or welding element, at an operating end of the robotic arm, can be located and operated within the nuclear vessel through movement derived from six different axes of motion provided by mounting and drive connections between arm sections of the robotic arm. The movements are achieved by operation of remotely-controllable servo motors, all of which are mounted at a control end of the robotic arm to be outside the nuclear vessel.

  1. Robotic arm

    International Nuclear Information System (INIS)

    A robotic arm positionable within a nuclear vessel by access through a small diameter opening and having a mounting tube supported within the vessel and mounting a plurality of arm sections for movement lengthwise of the mounting tube as well as for movement out of a window provided in the wall of the mounting tube is disclosed. An end effector, such as a grinding head or welding element, at an operating end of the robotic arm, can be located and operated within the nuclear vessel through movement derived from six different axes of motion provided by mounting and drive connections between arm sections of the robotic arm. The movements are achieved by operation of remotely-controllable servo motors, all of which are mounted at a control end of the robotic arm to be outside the nuclear vessel. 23 figs

  2. 美军伊拉克和阿富汗战争战伤救治新理念%New concepts of combat trauma care in the US Armed Forces during Operation Enduring Freedom and Operation Iraqi Freedom

    Institute of Scientific and Technical Information of China (English)

    李丽娟; 刁天喜

    2013-01-01

    The tactical combat casualty care (TCCC) concept,first introduced by the US Navy Special Warfare Command in 1996 and used in the conflicts in Iraq and Afghanistan,has become the standard in all services in the US Armed Forces,which is also one of the major advances that the US Armed Forces achieved during Operation Iraqi Freedom(OIF)and Operation Enduring Freedom(OEF).The new concept of TCCC has brought the US military casualties to a record low in the nation's history.This paper describes the development of the TCCC by the US Armed Forces,discusses the three phases of TCCC care,investigates its organization and implementation and finally puts forward some lessons China can learn.%“战术战伤救治”的概念最早由美海军特种作战部队于1996年首次提出,在伊拉克和阿富汗战争中成为美军战术环境中伤员救治的标准规范,也是美军伊拉克和阿富汗战争中战伤救治取得的一大进展.战术战伤救治的应用使美军达到了有史以来最低的伤亡率.该文梳理了美军战术战伤救治理念的发展,分析了战术战伤救治的阶段划分,探讨了美军战术战伤救治的组织实施,并提出了对我军的启示.

  3. Children In Armed Conflicts

    OpenAIRE

    Ranjan, Tejaswini

    2013-01-01

    This is a descriptive study. A child soldier is a child under the age of 18 that is recruited into the armed forces and engages in political violence. Child Soldiers are recruited by a state or non-state armed group and used as fighters, cooks, suicide bombers, human shields, messengers, spies, or for sexual purposes. This work of research describes the plight of child soldiers taking in context the scenario of different nations. The International mechanisms to combat this problem have also b...

  4. Removable molar power arm

    OpenAIRE

    2013-01-01

    Attachment of force elements from the gingival hook of maxillary molar tubes during the retraction of the anterior teeth is very common in orthodontic practice. As the line of force passes below the center of resistance (CR) of molar, it results its mesial tipping and also anchorage loss. To overcome this problem, the line of force should pass along the CR of molar. This article highlights a method to overcome this problem by attaching a removable power arm to the headgear tube of molar tube ...

  5. Optimization in brachytherapy with the implementation of Radiobiology

    International Nuclear Information System (INIS)

    In the brachytherapy planning treatments with High dose rates (HDR), the optimization algorithms used are based in dosimetric considerations and/or geometric ones, ignoring the radiobiological response of the tissue treated. In this work we wish to show the implementation of radiobiological concepts in the optimization. Assuming that the subtiles differences that result in the dose distribution among the different optimization models which are not visible in an isodose plane, it is studied how is classically make it , the quality implant through natural histograms about dose volumes and the resulting parameters. Also is studied the necrosis probability which may be caused by the choice of some optimization model, allowing with this the choice of the best implant. (Author)

  6. Amchitka radiobiological program progress report, January 1976--December 1976

    International Nuclear Information System (INIS)

    The Amchitka Radiobiological Program is a continuing program to collect biological and environmental samples for radiometric analyses. Results of analyses for samples collected during 1976 include gamma-emitting radionuclides in air filters, freshwater, birds, lichens, marine algae, marine invertebrates, fish, aufwuchs, and freshwater moss and plants; 90Sr in rats, birds, and soil; 239240Pu in sand, soil, marine algae and fish; and tritium (3H) in seawater, freshwater, and biological organisms

  7. Radiobiology Department. Report of Activities 1977-1980

    International Nuclear Information System (INIS)

    The different research activities carried out by the Radiobiology Department of the CNEA over the 4-year period 1977-1980 are summarized. These activities were devoted to the study of the effects of radiation on different biological systems, to the search for adequate experimental models, and to the development of techniques permiting a correct evaluation of the information obtained. Topics covered are genetics, microbiology, somatic effects of radiation, pathology and the operation of the animal's house. (M.E.L.)

  8. (RadioBiological Optimization of External-Beam Radiotherapy

    Directory of Open Access Journals (Sweden)

    Alan E. Nahum

    2012-01-01

    Full Text Available “Biological optimization” (BIOP means planning treatments using (radiobiological criteria and models, that is, tumour control probability and normal-tissue complication probability. Four different levels of BIOP are identified: Level I is “isotoxic” individualization of prescription dose at fixed fraction number. is varied to keep the NTCP of the organ at risk constant. Significant improvements in local control are expected for non-small-cell lung tumours. Level II involves the determination of an individualized isotoxic combination of and fractionation scheme. This approach is appropriate for “parallel” OARs (lung, parotids. Examples are given using our BioSuite software. Hypofractionated SABR for early-stage NSCLC is effectively Level-II BIOP. Level-III BIOP uses radiobiological functions as part of the inverse planning of IMRT, for example, maximizing TCP whilst not exceeding a given NTCP. This results in non-uniform target doses. The NTCP model parameters (reflecting tissue “architecture” drive the optimizer to emphasize different regions of the DVH, for example, penalising high doses for quasi-serial OARs such as rectum. Level-IV BIOP adds functional imaging information, for example, hypoxia or clonogen location, to Level III; examples are given of our prostate “dose painting” protocol, BioProp. The limitations of and uncertainties inherent in the radiobiological models are emphasized.

  9. In vitro irradiation station for broad beam radiobiological experiments

    Science.gov (United States)

    Wéra, A.-C.; Riquier, H.; Heuskin, A.-C.; Michiels, C.; Lucas, S.

    2011-12-01

    The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.

  10. In vitro irradiation station for broad beam radiobiological experiments

    Energy Technology Data Exchange (ETDEWEB)

    Wera, A.-C., E-mail: anne-catharine.wera@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium); Riquier, H., E-mail: helene.riquier@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Unite de Recherche de Biologie Cellulaire (URBC), University of Namur-FUNDP, Rue de Bruxelles, 61, B-5000 Namur (Belgium); Heuskin, A.-C., E-mail: anne-catherine.heuskin@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium); Michiels, C., E-mail: carine.michiels@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Unite de Recherche de Biologie Cellulaire (URBC), University of Namur-FUNDP, Rue de Bruxelles, 61, B-5000 Namur (Belgium); Lucas, S., E-mail: stephane.lucas@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium)

    2011-12-15

    The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.

  11. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 20. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemannn, Hans-Peter; Zips, Daniel (eds.)

    2011-07-01

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  12. Application of SSNTDs in radiobiological investigations aboard recoverable satellites.

    Science.gov (United States)

    Huang, R Q; Gu, R Q; Li, Q

    1997-01-01

    In recent years some Biostack experiments including a wide spectrum of biological objects have been devoted to study of the radiobiological effects on dry seeds aboard recoverable satellites. Some impressive phenomena have been observed. Clearly, the large amount of energy deposited by the highly ionizing heavy nuclei of cosmic rays is the principal reason for the induced aberrations of the chromosomes of wheat root tip cells. A methodical description of the experimental arrangement and procedure of handling and evaluation of given. The preliminary physical and biological results from the experimental "wheat seeds" are presented. PMID:11541794

  13. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings

    International Nuclear Information System (INIS)

    The proceedings of the 25th symposium on experimental radiotherapy and clinical radiobiology include papers on the following issues: radiotherapy individualization based on imaging; pre-clinic imaging and new experimental methods; methods and models, micromilieu and metabolism, combined therapy; secondary tumors following radiotherapy; radiogenic effects in normal tissue; resistance mechanism of tumors and normal tissue; personalized radio-oncology - which biological data are needed; pre-clinic and personalized radio-oncology; biomarkers - pre-clinic and translational; translational examinations for personalized radio-oncology.

  14. Toxicological and radiobiological characteristics of some S -derivatives of meprin

    International Nuclear Information System (INIS)

    Structural variants with radiobiological properties of alpha-mercaptopropinolylglycine (α-MPG, thiol, meprin) are searched with the aim of revealing preparations with increased radioprotective properties. Results of studying toxicologic and radioprotective properties of a number of synthesized compounds-thiosulphate (TSPG) isothiouranium (ITPG) diethyldithiocarbamate (DDTCPG) and thiophosphate (TPPG) α-MPG derivatives, are presented. The experiments on mice have shown that PSPG has low toxicity and satisfactory radioprotective activity when introduced 4 hours before irradiation. DDTCPG brings about a slight protective effect in the dose of 1300 mg/kg it does not produce radioprotective effect. Low toxicity and high radioprotective TPPG effect prove the necessity of its further study

  15. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings

    International Nuclear Information System (INIS)

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity

  16. 武警部队机关干部工作精力与体质要求分析%Analysis of the Request of Working Energy and Physical Quality of Office Cadres in Armed Police Force

    Institute of Scientific and Technical Information of China (English)

    倪红军

    2012-01-01

    The paper analyzed the biological phenomena of the working staff in the management office of Armed Police Force through the form of questionnaire and test, detailed expounded the physical and mental request of the brain work and pointed out that a healthy body was an important component of new - style military working talents and work - out is a process from quantitative change to qualitative change of human functions.%运用问卷法和测试法对武警部队机关工作人员身体生物现象进行分析,详细论述了脑力工作对人体生理、心理的要求。指出:健康的体魄是新型部队机关人才构成的要素,体育锻炼是人体机能改善由量变到质变的过程。

  17. VI Congress on radiation research (radiobiology, radioecology, radiation safety). Abstracts. Volume 2 (sections VIII-XIV)

    International Nuclear Information System (INIS)

    The collection contains abstracts at the VI Congress on radiation research, in which program is included various aspects of ionizing and non-ionizing radiations on living organisms, problems of radioecology and radiation safety of humans and the environment. The Congress is dedicated to the 25th anniversary of the Chernobyl accident . Several reports have summarized the 25-year study of the effects of the accident, formulated forecasts and the main directions of further research. The second volume includes reports in sections : radioecology, combined effect of radiation and other environmental factors, agricultural radioecology, radiobiology of heavy ions, theoretical problems of radiobiology, systematic radiobiology. Radiobiology of non-ionizing radiation, biological effects, electromagnetic safety and regulation, radiobiological and radioecological education are discussed

  18. Development of radiobiology for oncology-a personal view

    International Nuclear Information System (INIS)

    When I came into radiotherapy in 1950, I was puzzled that some patients were treated to 3000 rads (cGy) in 3 weeks but others received 4000 in 5 or 6000 in 6 weeks. When I asked why, there were no convincing answers given, except 'this is what we usually do'. It wasn't until I went to a course on 'Radiobiology for Radiotherapy' in Cambridge that I learnt about the basic theories of Douglas Lea and the very considerable history of research into radiobiology and clinical radiotherapy. And there were still some questions outstanding, such as the relative importance of intracellular repair between 'daily' fractions, whether a 2 day gap each week was a good or a bad idea, and the role of proliferation, if any, during irradiation. I thought that a few simple animal experiments might help to give answers! That led me to a continuing interest in these questions and answers, which has taken me more than 50 years to pursue. This is the very personal story of what I saw happening in the subject, decade by decade. I was happy to experience all this together with scientists in many other countries, and our own, along the way. (review)

  19. A radiobiological review on melatonin. A novel radioprotector

    International Nuclear Information System (INIS)

    Complete text of publication follows. For the sake of improvement in radiation therapy, radiobiology plays a crucial role through explaining observed phenomena, and suggesting improvements to existing therapies. Due to the damaging effects of ionizing radiation, radiobiologists have long been interested in identifying novel, nontoxic, effective, and convenient compounds to protect humans against radiation induced normal tissue injuries. Melatonin (N-acetyl-5-methoxytryptamine), the chief secretory product of the pineal gland in the brain, has been documented to ameliorate the oxidative injuries due to ionizing radiation. This article reviews different features that make melatonin a potentially useful radioprotector. Moreover, based on radiobiological models we hypothesize that melatonin may postpone the saturation of repair enzymes which leads to repairing more induced damage by repair system and more importantly allows the use of higher doses of radiation during radiotherapy to get a better therapeutic ratio. The implications of the accumulated observations suggest by virtue of melatonin's radioprotective and anticancer effects; it is time to use it as a radioprotector both for radiation workers and patients suffering from cancer either alone for cancer inhibition or in combination with traditional radiotherapy for getting a favorable efficacy/toxicity ratio during the treatment. Although compelling evidence suggests that melatonin may be effective for a variety of disorders, the optimum dose of melatonin for human radioprotection is yet to be determined by further research. We propose that, in the future melatonin improve therapeutic ratio in radiation oncology.

  20. An irradiation facility with a vertical beam for radiobiological studies

    CERN Document Server

    Besserer, J; Dellert, M; Gahn, C; Moosburger, M; Pemler, P; Quicken, P; Distel, L; Schuessler, H

    1999-01-01

    A vertical beam facility for radiobiological experiments was designed and constructed at the Munich Tandem-Accelerator Laboratory. The main part of the facility is a 90 deg. dipole magnet bending the beam of protons or heavy particles into a vertical upward direction, which is advantageous for wet-cell irradiation. After collimation the beam is spread out passively by thin scattering foils and dynamically by magnetic coils. A homogeneity of the radiation field better than +-5% has been achieved over the diameter of the exit window of 60 mm. The dose rate can be widely adjusted from single particles to more than 10 sup 1 sup 0 particles (i.e. hundreds of Grays) per second. The dose measurement is based on single-particle counting and on standard dosimeters. The detector system for dosimetry and irradiation control is described. In a first radiobiological experiment the cell survival of chinese hamster cells was measured after irradiation with 22.7 MeV protons and compared with the X-ray result.

  1. Hypofractionation in prostate cancer: radiobiological basis and clinical appliance.

    Science.gov (United States)

    Mangoni, M; Desideri, I; Detti, B; Bonomo, P; Greto, D; Paiar, F; Simontacchi, G; Meattini, I; Scoccianti, S; Masoni, T; Ciabatti, C; Turkaj, A; Serni, S; Minervini, A; Gacci, M; Carini, M; Livi, L

    2014-01-01

    External beam radiation therapy with conventional fractionation to a total dose of 76-80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α / β . Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose) demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting. PMID:24999475

  2. Hypofractionation in Prostate Cancer: Radiobiological Basis and Clinical Appliance

    Directory of Open Access Journals (Sweden)

    M. Mangoni

    2014-01-01

    Full Text Available External beam radiation therapy with conventional fractionation to a total dose of 76–80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α/β. Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting.

  3. Some applications of radiation chemistry to biochemistry and radiobiology

    International Nuclear Information System (INIS)

    In this chapter illustrate the use of radiation chemistry as a tool in investigating biologically important radical reactions, and also outline some studies of models for radiobiological damage. Because aqueous solutions usually offer the most important matrix, an appreciation of the main features of water radiolysis will be essential. Most of the illustrations involve pulse radiolysis, and some familiarity with chemical kinetics is assumed. In addition to these and other chapters in this book, readers find the proceedings of a recent NATO Advanced Study Institute most useful. The authors shall not try to review here all the applications of radiation chemistry to biochemistry and biology, but they will illustrate, using selected examples, the main principles and practical advantages and problems. Another recent volume covers the main contributions of flash photolysis and pulse radiolysis to the chemistry of biology and medicine, complementing earlier reviews. Papers from symposia on radical processes in radiobiology and carcinogenesis, and on super-oxide dismutases, and proceedings of recent international congresses of radiation research, together with the other publications referred to above will enable the reader to gain a comprehensive overview of the role of radicals in biological processes and the contributions of radiation chemistry

  4. Influence of oxygen on the chemical stage of radiobiological mechanism

    Science.gov (United States)

    Barilla, Jiří; Lokajíček, Miloš V.; Pisaková, Hana; Simr, Pavel

    2016-07-01

    The simulation of the chemical stage of radiobiological mechanism may be very helpful in studying the radiobiological effect of ionizing radiation when the water radical clusters formed by the densely ionizing ends of primary or secondary charged particle may form DSBs damaging DNA molecules in living cells. It is possible to study not only the efficiency of individual radicals but also the influence of other species or radiomodifiers (mainly oxygen) being present in water medium during irradiation. The mathematical model based on Continuous Petri nets (proposed by us recently) will be described. It makes it possible to analyze two main processes running at the same time: chemical radical reactions and the diffusion of radical clusters formed during energy transfer. One may study the time change of radical concentrations due to the chemical reactions running during diffusion process. Some orientation results concerning the efficiency of individual radicals in DSB formation (in the case of Co60 radiation) will be presented; the influence of oxygen present in water medium during irradiation will be shown, too.

  5. Lever arm dysfunction in cerebral palsy gait

    OpenAIRE

    Theologis, Tim

    2013-01-01

    Skeletal structures act as lever arms during walking. Muscle activity and the ground reaction against gravity exert forces on the skeleton, which generate torque (moments) around joints. These lead to the sequence of movements which form normal human gait. Skeletal deformities in cerebral palsy (CP) affect the function of bones as lever arms and compromise gait. Lever arm dysfunction should be carefully considered when contemplating treatment to improve gait in children with CP.

  6. 78 FR 65244 - Defense Federal Acquisition Regulation Supplement: Contractor Personnel Supporting U.S. Armed...

    Science.gov (United States)

    2013-10-31

    ... personnel (as designated by USD (AT&L) or the combatant commander) supporting deployed U.S. Armed Forces... USD(AT&L) or the Combatant Commander, non-CAAF personnel supporting U.S. Armed Forces deployed...

  7. Report on the behalf of the Foreign Affairs, Defense and Armed Forces Commission on the bill project, adopted by the National Assembly, related to the struggle against the proliferation of arms of massive destruction and their vectors; Rapport fait au nom de la commission des affaires etrangeres, de la defense et des forces armees (1) sur le projet de loi, ADOPTE PAR L'ASSEMBLEE NATIONALE, relatif a la lutte contre la proliferation des armes de destruction massive et de leurs vecteurs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This report recalls the origins of the bill project which is the implementation of the UN Security Council resolution 1540, the aim of which was to promote the setting up of efficient tools to struggle against proliferation. The bill project aims at updating and reinforcing the existing law arsenal. The report also contains remarks made by the Commission. The bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  8. The ROC Armed Forces and Civil Society in Natural Disaster Relief Operations—A Deepening Cooperation and the Establishment of Sound Disaster Relief System

    OpenAIRE

    Hsieh, Yih-Shiun

    2012-01-01

    The primary purpose of the design and build of military forces is to deal with traditional security threats, especially the military invasion from other country. Nowadays, such thinking is not enough for facing current non-traditional challenges caused by climate changes, such as volcanic eruptions, earthquakes, tsunamis, as well as floods and landslides. Owing to the rapid deployment and effectiveness of military organization in case of crisis-whether manmade or natural, so any government of...

  9. Functions and structure of nuclear deterrence in the post-cold war world. More for less - an arms control strategy for the 1990s. A SIOP for Perestroika. Theater nuclear forces and extended deterrence in a multipolar world. Special series report

    Energy Technology Data Exchange (ETDEWEB)

    Snow, D.M.; Wooten, R.E.; Sundberg, E.E.; Szafranski, R.; Booker, D.L.

    1992-06-01

    This Publication includes: Essay (1). The Function and Structure of Nuclear Deterrence in the Post-Cold War World. Essay (2). More for Less-An Arms Control Strategy for the 1990s. Essay (3). A SIOP for Perestroika. Essay (4). Theater Nuclear Forces and Extended Deterrence in a Multipolar World.

  10. Operation and Maintenance of the National Radiobiology Archives

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Anthony C. James; Stacey L. McCord

    2012-03-07

    The National Radiobiology Archives (NRA) are an archival program, started in 1989, to collect, organize and maintain data, laboratory notebooks, and animal tissue specimens from government (Department of Energy and its predecessor agencies) sponsored radiobiology life-span animal studies. These unique records, histopathology slides and paraffin embedded tissue blocks are maintained in a central facility and are available for further research study. The materials include electronic and paper records for each of more than 6,000 life-span-observations on dogs as well as details of major studies involving nearly 30,000 mice. Although these studies were performed over many years and at different laboratories with differing data management systems, the NRA has translated them into a standardized set of relational database tables. These can be distributed to interested individuals on written request. Specific Aims are: (1) To Maintain the Archive of Written Records from the Animal Experiments - The USTUR continued to maintain the NRA archives which consist of approximately 175 storage boxes containing laboratory notebooks, animal exposure records, animal pathologic records, and radiographs. These were stored in a 6,000 square foot leased facility in Richland, WA. Additionally, through a collaboration with Pacific Northwest National Laboratory's (PNNL) Low Dose Program, many of these records were scanned into digital files. These totaled 34 GB of data, which are saved in 2,407 separate PDF files that are organized by box number and animal identification number. (2) To Maintain the Archive of Animal Tissues at Washington State University - The USTUR continued to house the NRA dog tissue collection in the leased facility. The NRA tissue collection consisted of pathology slides and tissue blocks. Approximately 25% of the laboratory facility was dedicated to the storage of the NRA materials. (3) To Organize the Datasets of These Animals in the Context of Other Datasets so

  11. Out of sight, out of mind? The psychosocial needs of children formerly associated with armed forces: a case study of Save the Children UK's work in Beni and Lubero territories, North Kivu province, Democratic Republic of Congo.

    Science.gov (United States)

    Stott, Katharine

    2009-10-01

    Research into the psychosocial needs of children formerly associated with armed forces (CAAF) has aroused much interest in the past 60 years. Despite this, much debate remains surrounding how to optimally address these issues. The overwhelming stance of modern authors is that intervention must move away from the former focus on purely psychological intervention, to encompass broader social and cultural issues in addition. Hosted by Save the Children UK (SCUK), this qualitative research explores the perceptions of former CAAF, their communities and local SCUK staff of the psychosocial needs of former CAAF. Semi-structured interviews and focussed group discussions were conducted with 62 former CAAF (29 boys, 33 girls), 21 community members and 7 staff members of SCUK or its partner organizations in Beni and Lubero territories of North Kivu province, eastern Democratic Republic of Congo. Findings are presented and were analysed within a conceptual framework proposed by the Psychosocial Working Group. It was found that whilst the social needs of former CAAF and their communities are great, psychological challenges are prevalent and serious; moreover these psychological challenges impact the social integration of former CAAF. In addition, the needs of female former CAAF should be addressed differently to those of males, due primarily to the children most of the girls have conceived during their time with armed groups. The current movement of psychosocial theory from a psychological to a social focus is reflective of an attempt to address developmental concerns at the neglect of humanitarian needs. In consequence, former CAAF are being offered substandard assistance which fails to optimize their chances for successful civilian reintegration. PMID:19957306

  12. Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

    CERN Document Server

    Boissonnat, G; Balanzat, E; Boumard, F; Carniol, B; Colin, J; Cussol, D; Etasse, D; Fontbonne, C; Frelin, A -M; Hommet, J; Peronnel, J; Salvador, S

    2016-01-01

    Currently, radiobiology experiments using heavy ions at GANIL(Grand Acc\\'el\\'erateur National d'Ions Lourds) are conducted under the supervision of the CIMAP (Center for research on Ions, MAterials and Photonics). In this context, a new beam monitoring equipment named DOSION has been developed. It allows to perform measurements of accurate fluence and dose maps in near real time for each biological sample irradiated. In this paper, we present the detection system, its design, performances, calibration protocol and measurements performed during radiobiology experiments. This setup is currently available for any radiobiology experiments if one wishes to correlate one's own sample analysis to state of the art dosimetric references.

  13. Studies in the radiobiology of osteoradionecrosis and their clinical significance

    Energy Technology Data Exchange (ETDEWEB)

    Marx, R.E.; Johnson, R.P.

    1987-10-01

    The radiobiology of osteoradionecrosis is a complex of cellular death and cellular functional impairments from radiation energy transfers. Four studies of irradiated patients and a data base from 536 patients with osteoradionecrosis revealed separate pathophysiologic conditions for osteoradionecrosis induced by early trauma, osteoradionecrosis induced by late trauma, and spontaneous osteoradionecrosis. A large body of data suggested useful clinical guidelines for the management of irradiated patients. The guidelines, in part, include a recommendation for deferring radiation treatment for 21 days after tissue wounding, if possible; a relative contraindication to wounding tissue during a radiation course; a recommendation for the use of hyperbaric oxygen before wounding; and a strong recommendation to provide comprehensive dental care to the irradiated patient.

  14. Philosophy of veterinary radiobiology twenty years after the Chernobyl disaster

    International Nuclear Information System (INIS)

    The basic objective is to provide safe foodstuffs. This approach has connection with the food chain protection including the diagnostics and the acute radiation disease therapy at the farm animals. The extra significance is given to the research of technologies which can reduce the activity of the contaminated foodstuffs. In the field of the ionizing radiation effect research in live organisms attention should be devoted to the new alternative bio-tests. The low-dose effect or the interaction with other negative physical and chemical aspects of the environment is mainly considered. In cooperation with human medicine, it is necessary to develop radiotherapy and to study the effects of therapy and radiotherapy. From the standpoint of perspective technologies, it is advisable to focus on irradiation of the foodstuffs in veterinary radiobiology. (authors)

  15. Dictionary of radiation protection, radiobiology and nuclear medicine

    International Nuclear Information System (INIS)

    Radiation protection, including aspects of radiobiology, nuclear medicine, and nuclear legislation, has an important role within nuclear research and the use of radioactive materials. Radiation protection comprises all measures and efforts to prevent the unwanted distribution and negative influence of ionizing radiation, especially where the human organism and the living environment are involved. The increasing role of radiation protection is reflected by the foundation of institutes in all industrial countries to control such radiant energy and prevent radiation damage. Nowadays ionizing radiation is employed on a large scale for basic investigations in biochemistry, molecular biology and genetics, in soil tests, fertilization problems and pest control in agriculture, as well as for medicinal diagnoses and therapy. This dictionary is a thematic enlargement of the four-language 'Dictionary of Nuclear Engineering', compiled by the same author. It comprises about 12,000 terms in each language. (orig.)

  16. Design of a Dynamic Arm Support (DAS) for gravity compensation

    NARCIS (Netherlands)

    Kramer, Gijs; Römer, GertWillem R.B.E.; Stuyt, Harry J.A.

    2007-01-01

    The Dynamic Arm Support, or briefly the Das, is a new medical device that serves to compensate for lost arm function of the severely disabled. The target group suffers from insufficient muscle force to move its arms over the usual Range of Motion (RoM). The purpose of the Das is to assist its user d

  17. Method for validating radiobiological samples using a linear accelerator

    International Nuclear Information System (INIS)

    There is an immediate need for rapid triage of the population in case of a large scale exposure to ionizing radiation. Knowing the dose absorbed by the body will allow clinicians to administer medical treatment for the best chance of recovery for the victim. In addition, today's radiotherapy treatment could benefit from additional information regarding the patient's sensitivity to radiation before starting the treatment. As of today, there is no system in place to respond to this demand. This paper will describe specific procedures to mimic the effects of human exposure to ionizing radiation creating the tools for optimization of administered radiation dosimetry for radiotherapy and/or to estimate the doses of radiation received accidentally during a radiation event that could pose a danger to the public. In order to obtain irradiated biological samples to study ionizing radiation absorbed by the body, we performed ex-vivo irradiation of human blood samples using the linear accelerator (LINAC). The LINAC was implemented and calibrated for irradiating human whole blood samples. To test the calibration, a 2 Gy test run was successfully performed on a tube filled with water with an accuracy of 3% in dose distribution. To validate our technique the blood samples were ex-vivo irradiated and the results were analyzed using a gene expression assay to follow the effect of the ionizing irradiation by characterizing dose responsive biomarkers from radiobiological assays. The response of 5 genes was monitored resulting in expression increase with the dose of radiation received. The blood samples treated with the LINAC can provide effective irradiated blood samples suitable for molecular profiling to validate radiobiological measurements via the gene-expression based biodosimetry tools. (orig.)

  18. A statistical method for descriminating between alternative radiobiological models

    International Nuclear Information System (INIS)

    Radiobiological models assist understanding of the development of radiation damage, and may provide a basis for extrapolating dose-effect curves from high to low dose regions. Many models have been proposed such as multitarget and its modifications, enzymatic models, and those with a quadratic dose response relationship (i.e. αD + βD2 forms). It is difficult to distinguish between these because the statistical techniques used are almost always limited, in that one method can rarely be applied to the whole range of models. A general statistical procedure for parameter estimation (Maximum Liklihood Method) has been found applicable to a wide range of radiobiological models. The curve parameters are estimated using a computerised search that continues until the most likely set of values to fit the data is obtained. When the search is complete two procedures are carried out. First a goodness of fit test is applied which examines the applicability of an individual model to the data. Secondly an index is derived which provides an indication of the adequacy of any model compared with alternative models. Thus the models may be ranked according to how well they fit the data. For example, with one set of data, multitarget types were found to be more suitable than quadratic types (αD + βD2). This method should be of assitance is evaluating various models. It may also be profitably applied to selection of the most appropriate model to use, when it is necessary to extrapolate from high to low doses

  19. Refined testicular dosimetry and radiobiology in radionuclide therapy

    International Nuclear Information System (INIS)

    The full text of the publication follows. The testes are one of the most radiosensitive organs. They constitute an important critical target tissue both for external and internal exposure during diagnostic or therapeutic use of radionuclides. The testis consists of an egg-shaped tissue containing a large number of lobules. These are occupied by one to four seminiferous tubules, where the spermatogenesis takes place, i.e. the complex process where germ cells proliferate and transform into spermatozoa. The testicular cells have different sensitivity to radiation with the highest sensitivity of the undifferentiated spermatogonia close of the basal cell layer, and lowest sensitivity of the more mature sperm cells migrating towards the lumen. Exposure of the testis may occur due to radiopharmaceutical administration in patients either for therapy or diagnostic purposes, which may result in considerable high absorbed dose to the testis and may harm the testicular germ cells. In general the mean absorbed dose to the whole testis is estimated, which has been reported for different radionuclides and radiopharmaceuticals in the literature. However, due to the difference in radiosensitivity of the germ cells the absorbed doses to each type of cells in the seminiferous epithelium is of importance for a radiobiological interpretation. Testicular dosimetry on the cellular level is a complex matter and has not yet been addressed. The aim of this project was to design a small-scale anatomy model for calculation of S-factors (Gy MBq-1) for different source-target combinations, i.e. the interstitial tissue and different germ cells of the seminiferous epithelium. Based on this small-scale anatomy model it should be possible to estimate radiobiological effects based on radioactivity distribution determined by autoradiography, calculated differentiated absorbed doses, and known radiosensitivity of the different germ cells. The novel small-scale anatomy model will be presented and its

  20. The radiobiology/radiation protection interface in healthcare

    International Nuclear Information System (INIS)

    The current knowledge of radiation effects is reviewed and implications for its application in healthcare considered. The 21st L H Gray conference gathered leading experts in radiobiology, radiation epidemiology, radiation effect modelling, and the application of radiation in medicine to provide an overview of the subject. The latest radiobiology research in non-targeted effects such as genomic instability and the bystander effect challenge the old models, but the implications for health effects on humans are uncertain. Adaptive responses to external stresses, of which radiation is one, have been demonstrated in cells and animal models, but it is not known how these might modify human dose-effect relationships. Epidemiological evidence from the Japanese A-bomb survivors provides strong evidence that there is a linear relationship between the excess risk of cancer and organ dose that extends from about 50 mSv up to 2.5 Sv, and results from pooled data for multiple epidemiological studies indicate that risks extend down to doses of 20 mSv. Thus linear extrapolation of the A-bomb dose-effect data provides an appropriate basis for radiological protection standards at the present time. Risks from higher dose diagnostic procedures fall within the range in which health effects can be demonstrated. There is therefore reason for concern about the rise in the number of computed tomography (CT) scans performed in many countries, and in particular the use of CT for screening of asymptomatic individuals. New radiotherapy techniques allow high dose radiation fields to be conformed more effectively to target volumes, and reduce doses to critical organs, but they tend to give a higher and more uniform dose to the whole body which may increase the risk of second cancer. It is important that radiation protection practitioners keep abreast of developments in understanding of radiation effects and advise the medical community about the implications of fundamental research when

  1. Strategies to improve the efficacy of radioimmunotherapy: Radiobiologic aspects

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate methods of improving the therapeutic index (dose to tumor/dose to normal organs) and, hence, the efficacy of radioimmunotherapy (RIT). One method investigated was to increase the biologic response for a given radiation dose to tumor. To enhance the biologic efficacy of the dose, initial studies focused on first understanding the radiobiology of RIT irradiation and determining what role factors, such as radiation repair, repopulation, and redistribution, play in determining RIT response. In vitro studies using 4 colon carcinoma cell lines have compared the radiobiologic efficacy of low dose-rate irradiation delivered by Yttrium-90 (Y-90) with conventional high dose-rate external beam irradiation (XRT). Results suggested that one factor which determined a cell's sensitivity to Y-90 irradiation was its ability to repair radiation sublethal damage. In vivo studies demonstrated that those cell lines which were more sensitive to Y-90 irradiation in vitro were also more sensitive to RIT in vivo. For a more radioresistant line, WiDr, RIT was approximately two-fold less effective than an equivalent dose of single fraction XRT, while for a more radiosensitive line, LS174T, RIT was approximately as effective as an equivalent dose of single fraction XRT. Therefore, a tumor's response to RIT in vivo appeared to be, in part, dependent on the tumor cell's ability to repair radiation damage. Finally, studies investigated strategies at enhancing the biologic efficacy of RIT irradiation by combining RIT with chemotherapy agents that can potentially inhibit radiation repair. Agents, such as 5-fluorouracil, appeared to be synergistic with RIT irradiation n vitro and may therefore prove promising in improving the therapeutic index of RIT

  2. Mao Zedong' s Experience on the Armed Forces Being Also a Working Team%解放战争后期毛泽东工作队的经验及其启示

    Institute of Scientific and Technical Information of China (English)

    兰洋

    2012-01-01

    解放战争后期,尤其是辽沈、淮海、平津三大战役胜利结束以后,毛泽东审时度势,及时地提出了军队不仅是战斗队而且是工作队,要求军队干部应当学会接收、管理城市和新区工作,对促进当时新解放区干部问题的解决和革命事业的顺利发展起到了巨大的促进作用。在新世纪新阶段,我军要借鉴毛泽东的工作队经验。努力做到突出核心军事能力建设,注重非战争军事行动能力建设,注重培养“学习型”高素质复合型军事人才,为维护国家安全、社会稳定和经济发展作贡献。%In the later stage of War of Liberation,especially after Liaoxi-Shenyang,Huai-Hai and Beiping-Tianjing Campaigns, Mao Zedong, correctly appraising the situations, presented the thinking that the armed forces were not only a fighting team but also a working team,requiring that cadres should learn to take over and manage cities and new areas.That has played an important role in developing the cause of the revolution. In the new era,our armed forces should draw lessons from Mao Zedong's experience on the working team,strive to give prominence to improving the core military capacity, focus on the improvement of their unmilitary capacity, try hard to train "learning-oriented" high-quality composite type personnel, safeguard China's security and contribute to economic and social development.

  3. 基层指挥士官胜任特征问卷的初步编制%Formulation of the competency trait scale for noncommissioned officers in Chinese People's Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    刘红; 孙丽云; 王宪利; 许爱萍

    2012-01-01

    Objective To formulate a competency trait scale (CTS) for noncommissioned officers in Chinese People ' s Armed Police Forces and to confirm its reliability and validity. Methods 572 noncommissioned officers were measured using the competency trait scale (CTS). Results Based on item analysis and exploring factor analysis , the scale involved five dimensions : self-control, organization commitment, achievement motivation , communication ability and responsibility. The alpha coefficient of the scale was 0.888, while that of other dimensions was 0.806, 0.750, 0.718, 0.682, and 0.682, respectively. The retest coefficient was 0.825. There was significant difference between ordinary noncommissioned officers and excellent noncommissioned officers in each dimension of CTS. The job performance of noncommissioned officers was positively correlated with self - control, organization commitment, achievement motivation, responsibility and the total score of competency trait. Conclusions CTS is highly reliable and valid as a psychologi -cal tool for noncommissioned officers in Armed Police Forces .%目的 编制符合武警部队基层指挥士官胜任特征的问卷.方法 整群抽取武警某部士官572名,使用自编胜任特征问卷进行评估.结果 根据项目分析、探索性因素分析确定该问卷包含5个维度,分别为自我控制、组织承诺、成就动机、沟通能力及责任心.该问卷的内部一致性信度(α系数)为0.888,各维度α系数分别为:0.806,0.750,0.718,0.682,0.682.重测信度为0.825.普通士官与优秀士官在胜任特征各维度上差异有统计学意义(P<0.05),士官的工作绩效总分与自我控制、组织承诺、成就动机、责任感及胜任特征总分具有较高的正相关(P<0.05).结论 该问卷具有良好的信度和效度,可以作为武警基层指挥士官评估、选拔与培训的心理测量工具.

  4. Knowledge evolution on effects of ionizing radiations on living being. New prospects of radiobiological researches

    International Nuclear Information System (INIS)

    The knowledge increase of all the steps going from the material radiation interaction to the risk evaluation, prevention and irradiation consequences treatment leads to new prospects in radiobiology research, such as the low doses effects. (A.B.)

  5. Recent trends in radiobiology of skin and repercussions for dose limitation and personal dosimetry

    International Nuclear Information System (INIS)

    Recent advances in the radiobiology of skin are reviewed with particular emphasis on those aspects relevant to the updating of radiological protection criteria for skin dose limitation which is currently being undertaken by the ICRP and NCRP. (author)

  6. Press breakfast, radiobiology stakes: an European context, Thursday 25 March 2004

    International Nuclear Information System (INIS)

    The radiobiology endeavours to know the ionizing radiations effects on living systems, particular at low doses exposures. The researches in this area contribute to the elaboration of international regulation on nuclear industry. The individual radiosensitivity is an other aspect of the research in radiobiology. These studies should allow the establishing of radiation protection standards founded on a direct approach and an individual estimation of the level of acceptable dose. (N.C.)

  7. Proceedings of scientific conference of young scientists 'Fundamental and applied problems of radiobiology and radioecology'

    International Nuclear Information System (INIS)

    This book contains modern views on mechanisms of biological effects of ionising radiation in low doses and peculiarities of radionuclide migration in different ecosystems which are based on experimental data in works of young scientists represented on research conference 'Fundamental and applied problems of radiobiology and radioecology'. Special attentions of this publication are investigations in fields of radiation genetics and biochemistry, medical an biological aspects of radiation exposure, plant radiobiology and radioecology

  8. Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm.

    Science.gov (United States)

    Dura-Bernal, Salvador; Zhou, Xianlian; Neymotin, Samuel A; Przekwas, Andrzej; Francis, Joseph T; Lytton, William W

    2015-01-01

    Embedding computational models in the physical world is a critical step towards constraining their behavior and building practical applications. Here we aim to drive a realistic musculoskeletal arm model using a biomimetic cortical spiking model, and make a robot arm reproduce the same trajectories in real time. Our cortical model consisted of a 3-layered cortex, composed of several hundred spiking model-neurons, which display physiologically realistic dynamics. We interconnected the cortical model to a two-joint musculoskeletal model of a human arm, with realistic anatomical and biomechanical properties. The virtual arm received muscle excitations from the neuronal model, and fed back proprioceptive information, forming a closed-loop system. The cortical model was trained using spike timing-dependent reinforcement learning to drive the virtual arm in a 2D reaching task. Limb position was used to simultaneously control a robot arm using an improved network interface. Virtual arm muscle activations responded to motoneuron firing rates, with virtual arm muscles lengths encoded via population coding in the proprioceptive population. After training, the virtual arm performed reaching movements which were smoother and more realistic than those obtained using a simplistic arm model. This system provided access to both spiking network properties and to arm biophysical properties, including muscle forces. The use of a musculoskeletal virtual arm and the improved control system allowed the robot arm to perform movements which were smoother than those reported in our previous paper using a simplistic arm. This work provides a novel approach consisting of bidirectionally connecting a cortical model to a realistic virtual arm, and using the system output to drive a robotic arm in real time. Our techniques are applicable to the future development of brain neuroprosthetic control systems, and may enable enhanced brain-machine interfaces with the possibility for finer control of

  9. Cortical spiking network interfaced with virtual musculoskeletal arm and robotic arm

    Directory of Open Access Journals (Sweden)

    Salvador eDura-Bernal

    2015-11-01

    Full Text Available Embedding computational models in the physical world is a critical step towards constraining their behavior and building practical applications. Here we aim to drive a realistic musculoskeletal arm model using a biomimetic cortical spiking model, and make a robot arm reproduce the same trajectories in real time. Our cortical model consisted of a 3-layered cortex, composed of several hundred spiking model-neurons, which display physiologically realistic dynamics. We interconnected the cortical model to a two-joint musculoskeletal model of a human arm, with realistic anatomical and biomechanical properties. The virtual arm received muscle excitations from the neuronal model, and fed back proprioceptive information, forming a closed-loop system. The cortical model was trained using spike timing-dependent reinforcement learning to drive the virtual arm in a 2D reaching task. Limb position was used to simultaneously control a robot arm using an improved network interface. Virtual arm muscle activations responded to motoneuron firing rates, with virtual arm muscles lengths encoded via population coding in the proprioceptive population. After training, the virtual arm performed reaching movements which were smoother and more realistic than those obtained using a simplistic arm model. This system provided access to both spiking network properties and to arm biophysical properties, including muscle forces. The use of a musculoskeletal virtual arm and the improved control system allowed the robot arm to perform movements which were smoother than those reported in our previous paper using a simplistic arm.This work provides a novel approach consisting of bidirectionally connecting a cortical model to a realistic virtual arm, and using the system output to drive a robotic arm in real time. Our techniques are applicable to the future development of brain neuro-prosthetic control systems, and may enable enhanced brain-machine interfaces with the possibility

  10. Centralized Management of Military Health Strengths in Station Armed Forces%驻地部队卫勤力量集中调度管理模式改革

    Institute of Scientific and Technical Information of China (English)

    李曙光; 欧崇阳; 胡其平

    2011-01-01

    The author summarized the existing problems of station armed forces in health service person-nel , materials and equipment. Then, a new mode of health strength management was put forward, which included "integrating resources, centralized management and scientific development" , so as to reinforce the comprehensive effects of all level health institutions, serve the preparedness for emergency military region, complete diversified military operations, and satisfied the medical and health demands.%通过归纳目前驻地部队在卫勤人员、物资装备管理等方面存在的问题,对驻地部队“整合资源、集中调度、科学发展”的卫勤力量调度管理新模式进行探讨,以不断增强部队各级卫生机构建设的综合效益,为服务军事斗争准备、完成多样化军事任务、满足官兵医疗卫生需求提供强有力的支援.

  11. Zaštita računarskih mreža Ministarstva odbrane i Vojske Srbije primenom virtuelnog honeyneta / Security of computer network of the Ministry of Defence and the Serbian Armed Forces using virtual honeynets

    Directory of Open Access Journals (Sweden)

    Zoran Bobar

    2009-07-01

    Full Text Available U ovom radu obrađena je zaštita računarskih mreža u Ministarstvu odbrane i Vojsci Srbije primenom virtuelnog honeyneta. Zaštita je obrađena sa aspekta arhitekture računarskih mreža koje imaju pristup internetu. Predloženi koncept primene virtuelnog honeyneta uzima u obzir dostignuća nauke u ovoj oblasti u svetu, ostale primenjene metode i tehnike zaštite, mogućnosti i potrebe korisnika i elemente delova računarskog sistema Ministarstva odbrane i Vojske koji bi mogli biti meta napada sa udaljenih mesta globalne (internet mreže. / This paper covers the proposed solution for security of computer network in the Ministry of Defence and the Serbian Armed Forces using virtual honeynets. The security is covered from the aspect of the architecture of computer networks with Internet access. The proposed usage of virtual honeynets for protection takes into account the accomplishments of science in this field as well as security methods and techniques, users' needs and opportunities along with the computer network components of the MoD and the SAF that can be targets for attack.

  12. Evaluation of radiobiological effects in 3 distinct biological models

    International Nuclear Information System (INIS)

    Full text of publication follows. The present work aims at sharing the process of development of advanced biological models to study radiobiological effects. Recognizing several known limitations and difficulties of the current monolayer cellular models, as well as the increasing difficulties to use advanced biological models, our group has been developing advanced biological alternative models, namely three-dimensional cell cultures and a less explored animal model (the Zebra fish - Danio rerio - which allows the access to inter-generational data, while characterized by a great genetic homology towards the humans). These 3 models (monolayer cellular model, three-dimensional cell cultures and zebra fish) were externally irradiated with 100 mGy, 500 mGy or 1 Gy. The consequences of that irradiation were studied using cellular and molecular tests. Our previous experimental studies with 100 mGy external gamma irradiation of HepG2 monolayer cells showed a slight increase in the proliferation rate 24 h, 48 h and 72 h post irradiation. These results also pointed into the presence of certain bystander effects 72 h post irradiation, constituting the starting point for the need of a more accurate analysis realized with this work. At this stage, we continue focused on the acute biological effects. Obtained results, namely MTT and clonogenic assays for evaluating cellular metabolic activity and proliferation in the in vitro models, as well as proteomics for the evaluation of in vivo effects will be presented, discussed and explained. Several hypotheses will be presented and defended based on the facts previously demonstrated. This work aims at sharing the actual state and the results already available from this medium-term project, building the proof of the added value on applying these advanced models, while demonstrating the strongest and weakest points from all of them (so allowing the comparison between them and to base the subsequent choice for research groups starting

  13. Arms control: misplaced focus

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, W.A.; Derber, C.

    1986-03-01

    Most of the nuclear debate consists of arguments about which weapons systems should be built, controlled, canceled, frozen, or retired. Short of virtually complete, multilateral nuclear disarmament, however, no change in the pace, balance, or even the direction of the arms race can make much difference in the risk of nuclear war, the damage should one occur, or the division of international political power. This includes Star Wars, the nuclear freeze, and even large cuts in or stabilization of offensive nuclear arsenals. A better starting point for nuclear politics would be the insight that nuclear weapons have completely changed the logic of power as it has been handed down through the ages. Military force, perfected to its highest level, has invalidated itself - for in a nuclearized world, any resort to force by a nuclear power risks escalation to its ultimate level, and thus to oblivion for all. Trying to rationalize and control the ultimate force is far less realistic and important than limiting the provocation of conflict and the use of force at lower, non-nuclear levels - by the United States, it clients, and, to the extent possible, its adversaries. 13 references.

  14. Fisheries Radiobiology and the Discharge of Radioactive Wastes

    International Nuclear Information System (INIS)

    In the United Kingdom authorizations to discharge radioactive wastes are granted by the Minister of Housing and Local Government, the Minister of Agriculture, Fisheries and Food, and by the Secretary of State for Scotland. The hazards arising from contamination of aquatic animals and plants concern the Department of Fisheries ; before authorizations to discharge liquid wastes have been given, the Department has made independent forecasts of permissible levels of discharge based on extensive studies carried out in its research vessels and radiobiological laboratory: for example, where fish have been affected this has meant studies of fish populations and fish migration: uptake of radioactivity by fish : public consumption of fish : commercial distribution of affected fish: L.D.50: effects of radiation on tissue, etc. In the course of such work there has been close consultation with the Atomic Energy Authority, and agreement with the Atomic Energy Authority about the safety factor to be incorporated during the first two years of discharge. During these two years, monitoring data collected by the Atomic Energy Authority and the Ministry of Agriculture, Fisheries and Food enable checks and revisions of the original estimates to be made, and at the end of that time formal authorizations, based on operating experience, are issued. (author)

  15. Why do we need a new paradigm in radiobiology?

    International Nuclear Information System (INIS)

    Over the past 20 or so years experimental evidence, which questions the fundamentals of some 50 years standing, of both biology and radiobiology has accrued. In order to accommodate this new evidence within a framework that encompasses existing knowledge, attention has to be paid to the organisational or epigenetic, features of the cell. In recent years the high dimensional dynamic attractor has emerged as a potential organisational or regulatory agent that represents phenotype. It is argued here that its limited robustness provides a modus operandi to account for stress induced genomic instability. When radiation deposition events act to overcome the robustness of a normal or 'home' attractor in the cell of an established species and cause a transition to a variant attractor or phenotype, the consequences are unrelated to any specific molecular damage to the genomic DNA. Rather they correspond to the loss of evolutionarily acquired stability (genotypic replicative integrity) and robustness. Such processes are termed type B events and give rise to a separate category of effects and risk to those associated with the conventional effects of radiation, type A effects. How type B risks might be assessed is discussed.

  16. Radiobiological basis of radiation protection and ICRP 2007 general recommendations

    International Nuclear Information System (INIS)

    The ICRP 2007 General Recommendations are based on the detailed review of the new information on the biological effects and risk evaluation done during the last decade. Most of this information reinforces the validity of earlier findings. Since the publication of ICRP 60 general recommendations in 1991(ICRP 1991b), sufficient new information on the health effects of ionizing radiations has accrued based on radiobiological and epidemiological studies (UNSCEAR 2000, ICRP Publication 99). There is an improvement in understanding the mechanistic aspects of the induction of radiation damage at cellular level. Biophysical studies based on Monte Carlo track structure codes have provided information on the nature of critical damage to DNA leading to the radiation effects at cellular level. Experimental work with model animal systems has provided information on the role of post irradiation repair processes and the genes influencing the process of radiation carcinogenesis. Longer follow up of A-Bomb survivors of Hiroshima and Nagasaki now provides a more reliable risk estimate based on the cancer incidence data and also a better model for the transfer of risk among different populations with varying frequency of background incidence. At present it is clear that the breast cancer contributes substantially to the radiation risk and provides quantitative risk estimates for brain and salivary glands. In the light of the new information, Tissue Weighting factors (WT) have been revised

  17. Amchitka Radiobiological Program. Final report, July 1970-December 1979

    International Nuclear Information System (INIS)

    The Amchitka Radiobiological Program, to collect biological and environmental samples for radiological analyses, began in 1970 and continued through 1979. The principal objective was to determine the extent of radionuclide contamination from worldwide atmospheric fallout and from the detonation of three underground nuclear tests on Amchitka. Leakage of radionuclides from the underground test sites would be suspected if the amount of contamination was significantly greater than could be attributed to worldwide fallout or if an unexpected assemblage of radionuclides was detected. No radionuclides from the underground sites were detected, except for tritium from the Long Shot test (1965) which produced increased tritium concentrations in surface water and freshwater plants near the test site. This final report compiles all previous data into one report and considers the temporal trends in these data. Two naturally occurring radionuclides, 40K and 7Be, were the most abundantly occurring radionuclides in most samples; in lichen samples either 137Cs or 144Ce had the highest activity. All samples were below applicable Radiation Protection Guides and by 1979 most samples were near or below the statistical detection limits. Increased concentrations of short-lived fallout radionuclides following the Chinese atmospheric tests were found in freshwater and seawater samples and in most indicator organisms

  18. Amchitka Radiobiological Program. Final report, July 1970-December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Sibley, T.H.; Tornberg, L.D.

    1982-11-01

    The Amchitka Radiobiological Program, to collect biological and environmental samples for radiological analyses, began in 1970 and continued through 1979. The principal objective was to determine the extent of radionuclide contamination from worldwide atmospheric fallout and from the detonation of three underground nuclear tests on Amchitka. Leakage of radionuclides from the underground test sites would be suspected if the amount of contamination was significantly greater than could be attributed to worldwide fallout or if an unexpected assemblage of radionuclides was detected. No radionuclides from the underground sites were detected, except for tritium from the Long Shot test (1965) which produced increased tritium concentrations in surface water and freshwater plants near the test site. This final report compiles all previous data into one report and considers the temporal trends in these data. Two naturally occurring radionuclides, /sup 40/K and /sup 7/Be, were the most abundantly occurring radionuclides in most samples; in lichen samples either /sup 137/Cs or /sup 144/Ce had the highest activity. All samples were below applicable Radiation Protection Guides and by 1979 most samples were near or below the statistical detection limits. Increased concentrations of short-lived fallout radionuclides following the Chinese atmospheric tests were found in freshwater and seawater samples and in most indicator organisms.

  19. Optimisation of exposure conditions for in vitro radiobiology experiments

    International Nuclear Information System (INIS)

    Despite the long history of using cell cultures in vitro for radiobiological studies, there is to date no study specifically addressing the dosimetric implications of flask selection and exposure environment in clonogenic assays. The consequent variability in dosimetry between laboratories impedes the comparison of results. In this study we compare the dose to cells adherent to the base of three types of commonly used culture flasks or plates. The cells are exposed to a 6MV clinical photon beam using either an open or a half blocked field. The depth of medium in each flask is varied with the medium surrounding the flask either water or air. The results show that the dose to the cells is more affected by the scattering conditions surrounding the flasks than by the level of filling within the flask. It is recommended that water or a water equivalent phantom material is used to surround the flasks or plates to approximate full scatter conditions at the cell layer. However for modulated fields, surrounding the 24 well plates with water-equivalent material is inadequate because of the large volume of air surrounding individual wells. Our results stress the importance of measuring the dose for new experimental configurations.

  20. Radiobiological problems connected to exposure from cosmic radiation

    International Nuclear Information System (INIS)

    Civil aircrews are exposed to cosmic radiation where the radiation contains a hadronic high energy component. Although radiobiological studies based on X-rays, γ-rays, fast neutrons and ions of varying LET values have shown that the repair of sublethal damage takes place in living cells at low doses, this ability decreases with increasing LET so that maximum radiation effects is observed at about 120 keV/μm. Experimental studies of the biological significance of the strong nuclear interaction reactions via very high energy neutrons, stopped negative pi mesons give signs of an increased effectiveness at very low doses from the present data. The few results obtained indicate that a collapse of the repair-mechanisms might take place for these fundamental reaction in nature. It is stressed that the contribution to the dose at present days civil air transport from cosmic radiation is small and taken care of by the existing recommendation for radiation protection., 8 refs., 7 figs., 5 tabs

  1. Amchitka Radiobiological Program. Progress report, January-December 1978

    International Nuclear Information System (INIS)

    The Amchitka Radiobiological Program began in 1970 and is a continuing program to collect biological and environmental samples for radiometric analyses. This report is an account of the program for calendar year 1978. Results of analyses for samples collected in August 1978 have been added to the tables of Seymour and Johnson (1978) which summarize the Amchitka program from 1970 to 1977 and include analyses for: (1) gamma-emitting radionuclides in freshwater, birds, lichens, marine algae, marine invertebrates, fish, aufwuchs, and freshwater moss and plants; (2) strontium-90 (90Sr) in rats, birds, and soil; (3) 239, 240Pu in sand, soil, marine algae, and fish; and (4) tritium (3H) in seawater, freshwater, and biological organisms. Monitoring of background radiation with survey instruments was added to the Laboratory's program in 1974, and the results of the five annual surveys since that date are included in this report. Conclusions from the results of the recent analyses are a reiteration of the results stated in Nelson and Seymour (1975a); namely, (1) no new radionuclides are present; (2) the most abundant radionuclides are naturally occurring beryllium-7 (7Be) and potassium-40 (40K); (3) the trace quantities of fission products and induced radionuclides are from world fallout; and (4) a trace of 3H contamination remains in some Long Shot ponds, as previously reported. It is concluded that there were no radionuclides of Milrow or Cannikin origin in the water, plants, or animals of Amchitka Island

  2. [Radiobiological analysis of cancerogenic risk values in radioepidemiological investigations].

    Science.gov (United States)

    Rozhdestvenskiĭ, L M

    2008-01-01

    The aim of the present article consisted in critical analysis of the epidemiological approach to radiocancerogenic risk estimation in region of low level radiation (LLR). The estimation is making by means of mathematician models that ignore a principal difference in biological action of LLR and high level radiation (HLR). The main formal characteristic of LLR action is the presence of a plateau in beginning of a dose-effect curve of radiogenic risk. It may be argued by the following positions: repeating the plateau-phenomenon on various radiobiological effects, in different tests and bioobjects, first; a paradoxical trend of reciprocal ERR/Sv increasing regarding dose decreasing in region of plateau, second, and third, the increasing of the curvature in dose-effect curve beginning. The presence of a plateau is associated with the presence of a real radiogenic risk threshold. Besides, the analysis of processes influencing significantly the dynamics of initial radiation injury of biologically important macromolecules showed the preference in region of LLR those, decreasing/eliminating genome damages. There is follows from mentioned above a necessity to evaluate radiogenic risks in LLR region separately from HLR region. PMID:18825986

  3. Radiobiological study by using laser-driven proton beams

    Science.gov (United States)

    Yogo, A.; Sato, K.; Nishikino, M.; Mori, M.; Teshima, T.; Numasaki, H.; Murakami, M.; Demizu, Y.; Akagi, S.; Nagayama, S.; Ogura, K.; Sagisaka, A.; Orimo, S.; Nishiuchi, M.; Pirozhkov, A. S.; Ikegami, M.; Tampo, M.; Sakaki, H.; Suzuki, M.; Daito, I.; Oishi, Y.; Sugiyama, H.; Kiriyama, H.; Okada, H.; Kanazawa, S.; Kondo, S.; Shimomura, T.; Nakai, Y.; Tanoue, M.; Sugiyama, H.; Sasao, H.; Wakai, D.; Kawachi, T.; Nishimura, H.; Bolton, P. R.; Daido, H.

    2009-07-01

    Particle acceleration driven by high-intensity laser systems is widely attracting interest as a potential alternative to conventional ion acceleration, including ion accelerator applications to tumor therapy. Recent works have shown that a high intensity laser pulse can produce single proton bunches of a high current and a short pulse duration. This unique feature of laser-ion acceleration can lead to progress in the development of novel ion sources. However, there has been no experimental study of the biological effects of laser-driven ion beams. We describe in this report the first demonstrated irradiation effect of laser-accelerated protons on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. The laser-driven ion beam is apotential excitation source for time-resolved determination of hydroxyl (OH) radical yield, which will explore relationship between the fundamental chemical reactions of radiation effects and consequent biological processes.

  4. Amchitka Radiobiological Program progress report, January 1979-December 1979

    International Nuclear Information System (INIS)

    The objective of the Amchitka Radiobiological Program for the period 1970-1979 was to determine the extent of radionuclide contamination from world-wide atmospheric fallout and from the detonation of three underground nuclear blasts on Amchitka Island. The objective is achieved, by the collection and radiological analyses of biological and environmental samples and by background radiation measurements. Leakage of radionuclides from the underground sites of the Amchitka nuclear detonations would be suspected if the contamination was significntly greater than would be expected from world fallout. An account of the program from July 1970 to December 1978 has been given in nine previous reports from the Laboratory of Radiation Ecology to the Nevada Operations Office of the US Department of Energy. This report is an account of the program for calendar year 1979. The results of analyses of the samples collected in 1979 lead to the same conclusions as in previous years; i.e., there is no evidence that the radionuclide contamination at Amchitka Island is greater than would be expected from world fallout except for a slight contamination of the Long Shot Mud Pits with tritium

  5. Feasibility of BNCT radiobiological experiments at the HYTHOR facility

    Science.gov (United States)

    Esposito, J.; Ceballos, C.; Soncin, M.; Fabris, C.; Friso, E.; Moro, D.; Colautti, P.; Jori, G.; Rosi, G.; Nava, E.

    2008-06-01

    HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in vivo radiobiological studies. In HYTHOR irradiation cavity, 1-6 mice can be simultaneously irradiated to study skin melanoma treatments with the BNCT (boron neutron capture therapy). The therapeutic effects of HYTHOR radiation field on mouse melanoma has been studied as a preliminary investigation before studying the tumour local control due to boron neutron capture effect after boronated molecule injection. The method to properly irradiate small animals has been precisely defined. Results show that HYTHOR radiation field is by itself effective in reducing the tumour-growth rate. This finding has to be taken into account in studying the effectiveness of new 10B carriers. A method to properly measure the reduction of the tumour-growth rate is reported and discussed.

  6. Dosimetry for radiobiological experiments using energetic heavy ions

    International Nuclear Information System (INIS)

    The availability of the Bevalac facility of energetic heavy ions with range greater than the size of small mammals makes possible the determination of the biological effects of relatively well defined high LET, whole body irradiation. With the increasing application of high-energy heavy ions in radiobiology there is a corresponding need to develop reliable techniques of both relative and absolute absorbed dose measurement. This paper describes dosimetry studies by the Health Physics Department of the Lawrence Berkeley Laboratory with activation detectors, ionization chambers, nuclear emulsion, thermoluminescent dosimeters and X-ray film. The application of these techniques to an experiment designed to study the leukemogenic effect of the whole-body irradiation of mice by 250 MeV/amu carbon ions is briefly described. Values of absorbed dose in tissue, obtained during this experiment, with a nitrogen filled ionization chamber and 7LiF thermoluminescent dosimeters are compared and shown to be in good agreement. As a result of this work a value for the average energy to produce an ion pair (W) in nitrogen by 250 MeV/amu 6+C ions of 37 +- eV was determined. Values of the efficiency of 7LiF relative to 60Co γ-rays for ions with dE/dx in the range 110-260 MeV g-1 cm2 are reported

  7. Radiobiological research on carnation chimerae Dianthus Caryophyllus L

    International Nuclear Information System (INIS)

    A radiobiological study of periclinal carnation chimerae is carried out by subjecting whole plants and cuttings at different physiological stages to cobalt 60 gamma radiation under different dose and dose rate conditions. The effects of these treatments are observed during cultivation of the treated plants and by microscopic examination of irradiated meristem sections. The destruction of meristem cells in proportions varying with the irradiation conditions leads to structural changes in the chimerae; the more frequent change is the formation of genetically homogeneous stalks from different genotypes existing in the irradiated plant. Treatment by ionizing radiations is thus a practical means of detecting periclinical chimerae which, as in the case of carnations, are very common in plants grown by vegetative propagation. However since more than two independent meristem cell groups are usually present it is not possible by this method alone to define the distribution of the differentent genotypes in these groups; additional genetic studies or cell labelling such as chlorophyll or genoma mutations are then necessary

  8. Novel Radiobiological Gamma Index for Evaluation of 3-Dimensional Predicted Dose Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Sumida, Iori, E-mail: sumida@radonc.med.osaka-u.ac.jp [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Yamaguchi, Hajime; Kizaki, Hisao; Aboshi, Keiko; Tsujii, Mari; Yoshikawa, Nobuhiko; Yamada, Yuji [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan); Suzuki, Osamu; Seo, Yuji [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Isohashi, Fumiaki [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan); Yoshioka, Yasuo [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Ogawa, Kazuhiko [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan)

    2015-07-15

    Purpose: To propose a gamma index-based dose evaluation index that integrates the radiobiological parameters of tumor control (TCP) and normal tissue complication probabilities (NTCP). Methods and Materials: Fifteen prostate and head and neck (H&N) cancer patients received intensity modulated radiation therapy. Before treatment, patient-specific quality assurance was conducted via beam-by-beam analysis, and beam-specific dose error distributions were generated. The predicted 3-dimensional (3D) dose distribution was calculated by back-projection of relative dose error distribution per beam. A 3D gamma analysis of different organs (prostate: clinical [CTV] and planned target volumes [PTV], rectum, bladder, femoral heads; H&N: gross tumor volume [GTV], CTV, spinal cord, brain stem, both parotids) was performed using predicted and planned dose distributions under 2%/2 mm tolerance and physical gamma passing rate was calculated. TCP and NTCP values were calculated for voxels with physical gamma indices (PGI) >1. We propose a new radiobiological gamma index (RGI) to quantify the radiobiological effects of TCP and NTCP and calculate radiobiological gamma passing rates. Results: The mean RGI gamma passing rates for prostate cases were significantly different compared with those of PGI (P<.03–.001). The mean RGI gamma passing rates for H&N cases (except for GTV) were significantly different compared with those of PGI (P<.001). Differences in gamma passing rates between PGI and RGI were due to dose differences between the planned and predicted dose distributions. Radiobiological gamma distribution was visualized to identify areas where the dose was radiobiologically important. Conclusions: RGI was proposed to integrate radiobiological effects into PGI. This index would assist physicians and medical physicists not only in physical evaluations of treatment delivery accuracy, but also in clinical evaluations of predicted dose distribution.

  9. Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments.

    Science.gov (United States)

    Fukuda, Mark M; Klein, Terry A; Kochel, Tadeusz; Quandelacy, Talia M; Smith, Bryan L; Villinski, Jeff; Bethell, Delia; Tyner, Stuart; Se, Youry; Lon, Chanthap; Saunders, David; Johnson, Jacob; Wagar, Eric; Walsh, Douglas; Kasper, Matthew; Sanchez, Jose L; Witt, Clara J; Cheng, Qin; Waters, Norman; Shrestha, Sanjaya K; Pavlin, Julie A; Lescano, Andres G; Graf, Paul C F; Richardson, Jason H; Durand, Salomon; Rogers, William O; Blazes, David L; Russell, Kevin L; Akala, Hoseah; Gaydos, Joel C; DeFraites, Robert F; Gosi, Panita; Timmermans, Ans; Yasuda, Chad; Brice, Gary; Eyase, Fred; Kronmann, Karl; Sebeny, Peter; Gibbons, Robert; Jarman, Richard; Waitumbi, John; Schnabel, David; Richards, Allen; Shanks, Dennis

    2011-01-01

    Vector-borne infections (VBI) are defined as infectious diseases transmitted by the bite or mechanical transfer of arthropod vectors. They constitute a significant proportion of the global infectious disease burden. United States (U.S.) Department of Defense (DoD) personnel are especially vulnerable to VBIs due to occupational contact with arthropod vectors, immunological naiveté to previously unencountered pathogens, and limited diagnostic and treatment options available in the austere and unstable environments sometimes associated with military operations. In addition to the risk uniquely encountered by military populations, other factors have driven the worldwide emergence of VBIs. Unprecedented levels of global travel, tourism and trade, and blurred lines of demarcation between zoonotic VBI reservoirs and human populations increase vector exposure. Urban growth in previously undeveloped regions and perturbations in global weather patterns also contribute to the rise of VBIs. The Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) and its partners at DoD overseas laboratories form a network to better characterize the nature, emergence and growth of VBIs globally. In 2009 the network tested 19,730 specimens from 25 sites for Plasmodium species and malaria drug resistance phenotypes and nearly another 10,000 samples to determine the etiologies of non-Plasmodium species VBIs from regions spanning from Oceania to Africa, South America, and northeast, south and Southeast Asia. This review describes recent VBI-related epidemiological studies conducted by AFHSC-GEIS partner laboratories within the OCONUS DoD laboratory network emphasizing their impact on human populations. PMID:21388569

  10. Pandemia de gripe A (H1N1: estrategia de vigilancia y vacunación en las Fuerzas Armadas Pandemic of swine flu (H1N1: strategies for surveillance and immunization in the Armed Forces

    Directory of Open Access Journals (Sweden)

    G.G. Cáceres Bermejo

    2011-12-01

    Full Text Available Las Fuerzas Armadas constituyen un colectivo de interés especial en cuanto a la vigilancia y prevención de la gripe. El objetivo de este trabajo es describir las medidas de Salud Pública adoptadas frente a la pandemia de gripe A (H1N1. Se elaboraron protocolos de actuación específicos, tanto en vigilancia epidemiológica como en vacunación, en territorio nacional y en zona de operaciones. El número de casos notificados de gripe A fue de 1223 (el 57,5% en el Ejército de Tierra, 10 necesitaron hospitalización, y no se produjo ninguna defunción. Se distribuyeron 67.800 vacunas pandémicas y la cobertura fue del 9,7%, la Unidad Militar de Emergencias fue donde se conseguieron coberturas más altas (45,9%. Se notificaron 613 efectos adversos a la vacunación, todos ellos fueron leves.The Armed Forces constitute a group of special interest for the surveillance and the prevention of influenza. The aim of this paper is to describe the public health measures taken in response to pandemic of Influenza A (H1N1. Specific protocols of action were designed for the epidemiological surveillance and the vaccination, for national territory and operation areas. The reported cases of Influenza A were 1223 (57,5% in the Army, 10 have required hospitalization, and no death has taken place. 67800 pandemic vaccines have been distributed and the coverage reached 9,7 %, the highest coverage of vaccination (45,9% was obtained in the UME (Emergencies Military Unit. 613 adverse effects to the vaccination were reported, but all of them were slight.

  11. Dynamics of Non-Steady Spiral Arms in Disk Galaxies

    CERN Document Server

    Baba, Junichi; Wada, Keiichi

    2012-01-01

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional $N$-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms are originated in the continual repetition of this non-linear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the co-rotation point. Due to interaction with their host arms, ...

  12. 76 FR 30497 - Armed Forces Day, 2011

    Science.gov (United States)

    2011-05-25

    ... continued resolve to respond to the call of duty and defend America and its people. From our earliest days... Independence of the United States of America the two hundred and thirty-fifth. (Presidential Sig.) [FR...

  13. Gender Integration and the Swedish Armed Forces

    DEFF Research Database (Denmark)

    Gustafsson, Daniel Marcus Sunil

    the organisation to reinforce the notion of women as inferior and subordinate to men, whereby the external hegemony is believed to be restored. Likewise, male Swedish peacekeepers’ demand for prostitution during international peacekeeping missions is explained in terms of a need to confirm manhood and as homo...

  14. The Latvian Armed Forces today / Raimonds Graube

    Index Scriptorium Estoniae

    Graube, Raimonds

    1999-01-01

    Ülevaade Läti kaitsevägede olukorrast, eesmärkidest, rahvusvahelisest koostööst ja valmistumisest liitumiseks NATO-ga. Tabelid: Läti kaitsejõudude planeerimise süsteem, käsuliinid, kaitsejõudude struktuur rahu- ja sõjaajal. Raimonds Graube biograafia

  15. Women entrepreneurs in the UK armed forces

    OpenAIRE

    McAvoy, D A

    2015-01-01

    Literature on entrepreneurship has been criticised on several grounds including a strong bias to examine masculine traits, being deeply rooted in the private sector, limited to economics, conceptualised as a specialist skill pertinent only to non-public entities, overly positivist, single causal and with a tendency to downplay the relevance of both the social and human sciences. The relatively few studies of female entrepreneurs in the public sector have been criticised on the grounds of priv...

  16. The significance of the choice of radiobiological (NTCP) models in treatment plan objective functions

    International Nuclear Information System (INIS)

    Full text: A Clinician's discrimination between radiation therapy treatment plans is traditionally a subjective process, based on experience and existing protocols. A more objective and quantitative approach to distinguish between treatment plans is to use radiobiological or dosimetric objective functions, based on radiobiological or dosimetric models. The efficacy of models is not well understood, nor is the correlation of the rank of plans resulting from the use of models compared to the traditional subjective approach. One such radiobiological model is the Normal Tissue Complication Probability (NTCP). Dosimetric models or indicators are more accepted in clinical practice. In this study, three radiobiological models, Lyman NTCP, critical volume NTCP and relative seriality NTCP, and three dosimetric models, Mean Lung Dose (MLD) and the Lung volumes irradiated at lOGy (V|0) and 20Gy (V20), were used to rank a series of treatment plans using, harm to normal (Lung) tissue as the objective criterion. None of the models considered in this study showed consistent correlation with the Radiation Oncologists plan ranking. If radiobiological or dosimetric models are to be used in objective functions for lung treatments, based on this study it is recommended that the Lyman NTCP model be used because it will provide most consistency with traditional clinician ranking.

  17. Radiobiological waste treatment-ashing treatment and immobilization with cement

    International Nuclear Information System (INIS)

    This report describes the results of the study on the treatment of radioactive biological waste in the China Institute for Radiation Protection (CIRP). The possibility of radiobiological waste treatment was investigated by using a RAF-3 type rapid ashing apparatus together with the immobilization of the resulted ash. This rapid ashing apparatus, developed by CIRP, is usually used for pretreatment of samples prior to chemical analysis and physical measurements. The results show that it can ash 3 kg of animal carcasses a batch, the ashing time is 5-7 h and the ash content is less than 4 wt%. The ashing temperature not exceeding 450 deg. C was used without any risk of high losses of radionuclides. The ash from the rapid ashing apparatus was demonstrated to be immobilized with ordinary silicate cement. The optimum cement/ash/water formulation of the cemented waste form was 35 ± 5 wt% cement, 29 ± 2 wt% water, and 36 ± 6 wt% ash. The performance of the waste form was in compliance with the technical requirements except for impact resistance. Mixing additives in immobilization formulations can improve the performance of the cemented ash waste form. The additives chosen were DH4A flow promoter as a cement additive and vermiculite or zeolite as a supplement. The recommended formulation, i.e. an improved formulation of the cemented ash waste form is that additives DH4A flow promoter and vermiculite (or zeolite) are added on the ground of optimum cement/ash/water formulation of the cemented waste form, the dosage of water, DH4A and vermiculite (or zeolite) is 70 wt%, 0.5 wt% and ≤ 5 wt% of the cement dosage, respectively. The cemented ash waste forms obtained meet all the requirements for disposal. (author). 12 refs, 7 figs, 13 tabs

  18. Heavy-ion tumor therapy: Physical and radiobiological benefits

    Science.gov (United States)

    Schardt, Dieter; Elsässer, Thilo; Schulz-Ertner, Daniela

    2010-01-01

    High-energy beams of charged nuclear particles (protons and heavier ions) offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon therapy. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum (Bragg peak) near the end of range with a sharp fall-off at the distal edge. Taking full advantage of the well-defined range and the small lateral beam spread, modern scanning beam systems allow delivery of the dose with millimeter precision. In addition, projectiles heavier than protons such as carbon ions exhibit an enhanced biological effectiveness in the Bragg peak region caused by the dense ionization of individual particle tracks resulting in reduced cellular repair. This makes them particularly attractive for the treatment of radio-resistant tumors localized near organs at risk. While tumor therapy with protons is a well-established treatment modality with more than 60 000 patients treated worldwide, the application of heavy ions is so far restricted to a few facilities only. Nevertheless, results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities. This article reviews the progress in heavy-ion therapy, including physical and technical developments, radiobiological studies and models, as well as radiooncological studies. As a result of the promising clinical results obtained with carbon-ion beams in the past ten years at the Heavy Ion Medical Accelerator facility (Japan) and in a pilot project at GSI Darmstadt (Germany), the plans for new clinical centers for heavy-ion or combined proton and heavy-ion therapy have recently received a substantial boost.

  19. Radiobiological basis for setting neutron radiation safety standards

    International Nuclear Information System (INIS)

    Present neutron standards, adopted more than 20 yr ago from a weak radiobiological data base, have been in doubt for a number of years and are currently under challenge. Moreover, recent dosimetric re-evaluations indicate that Hiroshima neutron doses may have been much lower than previously thought, suggesting that direct data for neutron-induced cancer in humans may in fact not be available. These recent developments make it urgent to determine the extent to which neutron cancer risk in man can be estimated from data that are available. Two approaches are proposed here that are anchored in particularly robust epidemiological and experimental data and appear most likely to provide reliable estimates of neutron cancer risk in man. The first approach uses gamma-ray dose-response relationships for human carcinogenesis, available from Nagasaki (Hiroshima data are also considered), together with highly characterized neutron and gamma-ray data for human cytogenetics. When tested against relevant experimental data, this approach either adequately predicts or somewhat overestimates neutron tumorigenesis (and mutagenesis) in animals. The second approach also uses the Nagasaki gamma-ray cancer data, but together with neutron RBEs from animal tumorigenesis studies. Both approaches give similar results and provide a basis for setting neutron radiation safety standards. They appear to be an improvement over previous approaches, including those that rely on highly uncertain maximum neutron RBEs and unnecessary extrapolations of gamma-ray data to very low doses. Results suggest that, at the presently accepted neutron dose limit of 0.5 rad/yr, the cancer mortality risk to radiation workers is not very different from accidental mortality risks to workers in various nonradiation occupations

  20. SU-E-T-385: 4D Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Fourkal, E; Hossain, M; Veltchev, I; Ma, C; Meyer, J; Horwitz, E [Fox Chase Cancer Center, Philadelphia, PA (United States); Nahum, A [Clatterbridge Centre for Oncology, Bebington (United Kingdom)

    2014-06-01

    Purpose: The linear-quadratic model is the most prevalent model for planning dose fractionation in radiation therapy in the low dose per fraction regimens. However for high-dose fractions, used in SRS/SBRT/HDR treatments the LQ model does not yield accurate predictions, due to neglecting the reduction in the number of sublethal lesions as a result of their conversion to lethal lesions with subsequent irradiation. Proper accounting for this reduction in the number of sublethally damaged lesions leads to the dependence of the survival fraction on the temporal structure of the dose. The main objective of this work is to show that the functional dependence of the dose rate on time in each voxel is an important additional factor that can significantly influence the TCP. Methods: Two SBRT lung plans have been used to calculate the TCPs for the same patient. One plan is a 3D conformal plan and the other is an IMRT plan. Both plans are normalized so that 99.5% of PTV volume receives the same prescription dose of 50 Gy in 5 fractions. The dose rate in each individual voxel is calculated as a function of treatment time and subsequently used in the calculation of TCP. Results: The calculated TCPs show that shorter delivery times lead to greater TCP, despite all delivery times being short compared to the repair half-time for sublethal lesions. Furthermore, calculated TCP(IMRT) =0.308 for the IMRT plan is smaller than TCP(3D) =0.425 for 3D conformal, even though it shows greater tumor hot spots and equal PTV coverage. The calculated TCPs are considerably lower compared to those based on the LQ model for which TCP=1 for both plans. Conclusion: The functional dependence of the voxel-by-voxel dose rate on time may be an important factor in predicting the treatment outcome and cannot be neglected in radiobiological modeling.

  1. Heavy-ion tumor therapy: Physical and radiobiological benefits

    Energy Technology Data Exchange (ETDEWEB)

    Schardt, Dieter; Elsaesser, Thilo; Schulz-Ertner, Daniela [GSI Helmholtzzentrum fuer Schwerionenforschung mbH (GSI), D-64291 Darmstadt (Germany); Markus-Krankenhaus, MVZ Radiologisches Institut, D-60431 Frankfurt/M. (Germany)

    2010-01-15

    High-energy beams of charged nuclear particles (protons and heavier ions) offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon therapy. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum (Bragg peak) near the end of range with a sharp fall-off at the distal edge. Taking full advantage of the well-defined range and the small lateral beam spread, modern scanning beam systems allow delivery of the dose with millimeter precision. In addition, projectiles heavier than protons such as carbon ions exhibit an enhanced biological effectiveness in the Bragg peak region caused by the dense ionization of individual particle tracks resulting in reduced cellular repair. This makes them particularly attractive for the treatment of radio-resistant tumors localized near organs at risk. While tumor therapy with protons is a well-established treatment modality with more than 60 000 patients treated worldwide, the application of heavy ions is so far restricted to a few facilities only. Nevertheless, results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities. This article reviews the progress in heavy-ion therapy, including physical and technical developments, radiobiological studies and models, as well as radiooncological studies. As a result of the promising clinical results obtained with carbon-ion beams in the past ten years at the Heavy Ion Medical Accelerator facility (Japan) and in a pilot project at GSI Darmstadt (Germany), the plans for new clinical centers for heavy-ion or combined proton and heavy-ion therapy have recently received a substantial boost.

  2. Toxicological characteristics and primary radiobiological screening of Cystizid-M

    International Nuclear Information System (INIS)

    The toxic and radioprotective properties of the potential radioprotector of the mollecular combination Cystisid-M (cysteamine-adenosin-5'-monophosphate - CAM) were investigated. The experiments were carried out on male mice C57BI irradiated with 137Cs source. The intraperitoneal administration of 1000 mg/kg b.w. and 500 mg/kg b.w., injected 15 min prior to the irradiation with 8,5 Gr (LD90/30) was performed, and orally 3000 mg/kg b.w. and 1500 mg/kg b.w. was introduced into the stomach 45 min prior to the irradiation with 8,2 Gr (LD83/30). The radioprotective effect of CAM was recorded according to: individual survival curves up to the 30th day; the biometrical coefficients 'ALPHA' (the individual survival expectancy in the population); and S30 (the group survival expectancy). At the intraperitoneal administration of the protector the values of LD50 = 1390 mg/kg b.w. and MPD (maximum permissible dose) = 1200 mg/kg b.w. were found. At the oral administration these doses were LD50/3 = 4630 mg/kg b.w. and MPD = 3500 mg/kg b.w. It was established that CAM injected intraperitoneally in a dose of 1000 mg/kg b.w. ensured 75% survival of the protected mice against 10% of the control ones, increased the mean survival of the deceased and reduced the percentage of the animals died during the height of the bone marrow syndrome. The twofold lower dose exetted a considerably slighter effect. At oral administration the protector did not significantly modify the survival of the animals. The data obtained revealed the perspectiveness of the tested protective agent radiobiological investigations are required

  3. Dynamics of Non-steady Spiral Arms in Disk Galaxies

    Science.gov (United States)

    Baba, Junichi; Saitoh, Takayuki R.; Wada, Keiichi

    2013-01-01

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional N-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms originates in the continual repetition of this nonlinear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the corotation point. Due to interaction with their host arms, the energy and angular momentum of the stars change, thereby causing radial migration of the stars. During this process, the kinetic energy of random motion (random energy) of the stars does not significantly increase, and the disk remains dynamically cold. Owing to this low degree of disk heating, short-lived spiral arms can recurrently develop over many rotational periods. The resultant structure of the spiral arms in the N-body simulations is consistent with the observational nature of spiral galaxies. We conclude that the formation and structure of spiral arms in isolated disk galaxies can be reasonably understood by nonlinear interactions between a spiral arm and its constituent stars.

  4. DYNAMICS OF NON-STEADY SPIRAL ARMS IN DISK GALAXIES

    International Nuclear Information System (INIS)

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional N-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms originates in the continual repetition of this nonlinear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the corotation point. Due to interaction with their host arms, the energy and angular momentum of the stars change, thereby causing radial migration of the stars. During this process, the kinetic energy of random motion (random energy) of the stars does not significantly increase, and the disk remains dynamically cold. Owing to this low degree of disk heating, short-lived spiral arms can recurrently develop over many rotational periods. The resultant structure of the spiral arms in the N-body simulations is consistent with the observational nature of spiral galaxies. We conclude that the formation and structure of spiral arms in isolated disk galaxies can be reasonably understood by nonlinear interactions between a spiral arm and its constituent stars.

  5. System For Research On Multiple-Arm Robots

    Science.gov (United States)

    Backes, Paul G.; Hayati, Samad; Tso, Kam S.; Hayward, Vincent

    1991-01-01

    Kali system of computer programs and equipment provides environment for research on distributed programming and distributed control of coordinated-multiple-arm robots. Suitable for telerobotics research involving sensing and execution of low level tasks. Software and configuration of hardware designed flexible so system modified easily to test various concepts in control and programming of robots, including multiple-arm control, redundant-arm control, shared control, traded control, force control, force/position hybrid control, design and integration of sensors, teleoperation, task-space description and control, methods of adaptive control, control of flexible arms, and human factors.

  6. Nuclear arms: ethics, strategy, politics

    Energy Technology Data Exchange (ETDEWEB)

    Woolsey, R.J. (ed.)

    1984-01-01

    The range of debate over strategy and arms control today is broader than it was in the late 1950s and early 1960s. In part this is because the early 1980s debate has involved questioning of the fundamental notion of deterrence - by no less than the American Catholic bishops. Today's debate has also seen a national nuclear freeze campaign that, although its congressional supporters have held firmly to a bilateral approach, was tilted perceptibly towards unilateralism by noncongressional leaders at their national conference in February 1983. In one way or another the authors wrestle with different aspects of one central question: could the beginning steps for any consensus be possible, in today's climate, on strategic issues. Ethical issues are addressed in the first 3 papers: Charles Krauthammer, On Nuclear Morality; Patrick Glynn, The Moral Case for the Arms Buildup; and Michael Quinlarc, Thinking Deterrence Through. Three chapters on strategic considerations include: Brent Snowcroft, Understanding the US Strategic Arsenal; William J. Perry, Technological Prospects for US Strategic Forces; and Richard Burt, The Strategic and Political Lessons of INF. Arms control and politics is treated in chapters by: Walter B. Slocombe, Arms Control: Prospects; and Colin S. Gray, Arms Control: Problems. The nonnuclear dimensions of strategy are discussed in chapters by Amory B. and L. Hunter Lovins, Reducing Vulnerability - The Energy Jugular; and Robert Kupperman, Vulnerable America. The chapters on space and defense are: Hans Mark, Arms Control and Space Technology; and Newt Gingrich and John Madison, Space and National Defense. The concluding chapters are by Sen. Sam Nunn, The Need to Reshape Military Stategy; and the editor, R. James Woolsey, The Politics of Vulnerability, 1980-1983.

  7. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    Science.gov (United States)

    Herrera, Higmar; Yañez, Elvia; López, Jesús

    2012-10-01

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerología de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  8. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Higmar; Yanez, Elvia; Lopez, Jesus [Centro Estatal de Cancerologia de Durango, Victoria de Durango, Durango (Mexico); ISSSTE General Hospital Dr. Santiago Ramon y Cajal, Victoria de Durango, Durango (Mexico)

    2012-10-23

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerologia de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  9. Actual problems of toxicology and radiobiology. Russian scientific conference with international participation. Book of abstracts

    International Nuclear Information System (INIS)

    The collection contains abstracts of the Russian scientific conference with international participation, which took place May 19-20, 2011 in St. Petersburg. Proceedings of the conference include a general description of the chemical and radiological factors of nature, questions of radiation ecology and ecotoxicology. Modern methods of toxicological and radiobiological researches, including evaluation of radiation and chemical risks, mechanisms of development, pathogenesis, clinical features, diagnosis and treatment of various forms of toxic and radiation processes are under consideration. Current approaches to prevention and early therapy of chemical and radiation injuries are given. Issues of radiation and chemical safety, as well as the problems of training in toxicology and radiobiology are discussed

  10. Skin carcinomas: Radiobiological principles, radiotherapeutic techniques and clinical management

    International Nuclear Information System (INIS)

    Purpose/Objective: The course will be divided into three major topics: (1) Review of radiobiological principles as they apply to the radiotherapeutic management of skin carcinomas: (2) review of radiotherapeutic techniques including beam qualities, beam collimation, tissue dose profiles, and the relative indications of external beam irradiation vs. brachytherapy; (3) comprehensive review of the tumor biology of skin malignancies, including malignant melanoma, and of the relative indications for radiotherapeutic and/or surgical management. (1) Review of critical data which have lead to currently applied principles of time-dose-volume concepts in the radiotherapeutic management of skin carcinomas. Emphasis will be placed on the relative importance of fraction size and overall treatment time on tumor control probability and acute and late normal tissue toxicity. (2) Considering that radiotherapy in the management of skin carcinomas is often used to minimize patient disfiguration and to preserve critical body functions (e.g. eye lids) the technical aspects of radiotherapy delivery are most critical. Careful evaluation of the extent of the lesions including evaluation of their depth of invasion will determine the quality of the radiation beams, orthovoltage and low energy electrons being the most useful. Beam harding for orthovoltage beams and secondary and tertiary (skin) collimation of appropriate electron beams are critical. For more extensive and deeply invasive lesions contour-shaping through customized bolus material is essential. Equally important is the familiarity with custom shielding of critical structures, such as eyes, ears, oral cavity and central nervous system structures. Brachytherapy applications in the treatment of skin carcinomas is limited but should be considered when implants with high dose uniformity can be constructed. (3) The discussion of clinical management will start with a discussion of tumor biological properties of the diverse malignant

  11. Skin carcinomas: radiobiological principles, radiotherapeutic techniques and clinical management

    International Nuclear Information System (INIS)

    Purpose/Objective: The course will be divided into three major topics: (1) Review of radiobiological principles as they apply to the radiotherapeutic management of skin carcinomas; (2) review of radiotherapeutic techniques including beam qualities, beam collimation, tissue dose profiles, and the relative indications of external beam irradiation vs. brachytherapy; (3) comprehensive review of the tumor biology of skin malignancies, including malignant melanoma, and of the relative indications for radiotherapeutic and/or surgical management. (1) Review of critical data which have lead to currently applied principles of time-dose-volume concepts in the radiotherapeutic management of skin carcinomas. Emphasis will be placed on the relative importance of fraction size and overall treatment time on tumor control probability and acute and late normal tissue toxicity. (2) Considering that radiotherapy in the management of skin carcinomas is often used to minimize patient disfiguration and to preserve critical body functions (e.g. eye lids) the technical aspects of radiotherapy delivery are most critical. Careful evaluation of the extent of the lesions including evaluation of their depth of invasion will determine the quality of the radiation beams, orthovoltage and low energy electrons being the most useful. Beam harding for orthovoltage beams and secondary and tertiary (skin) collimation of appropriate electron beams are critical. For more extensive and deeply invasive lesions contour-shaping through customized bolus material is essential. Equally important is the familiarity with custom shielding of critical structures, such as eyes, ears, oral cavity and central nervous system structures. Brachytherapy applications in the treatment of skin carcinomas is limited but should be considered when implants with high dose uniformity can be constructed. (3) The discussion of clinical management will start with a discussion of tumor biological properties of the diverse malignant

  12. Skin carcinomas: Radiobiological principles, radiotherapeutic techniques and clinical management

    International Nuclear Information System (INIS)

    Purpose/Objective: The course will be divided into three major topics: (1) Review of radiobiological principles as they apply to the radiotherapeutic management of skin carcinomas; (2) review of radiotherapeutic techniques including beam qualities, beam collimation, tissue dose profiles, and the relative indications of external beam irradiation vs. brachytherapy; (3) comprehensive review of the tumor biology of skin malignancies, including malignant melanoma, and of the relative indications for radiotherapeutic and/or surgical management. (1) Review of critical data which have led to currently applied principles of time-dose-volume concepts in the radiotherapeutic management of skin carcinomas. Emphasis will be placed on the relative importance of fraction size and overall treatment time on tumor control probability and acute and late normal tissue toxicity. (2) Considering that radiotherapy in the management of skin carcinomas is often used to minimize patient disfiguration and to preserve critical body functions (e.g. eye lids) the technical aspects of radiotherapy delivery are most critical. Careful evaluation of the extent of the lesions including evaluation of their depth of invasion will determine the quality of the radiation beams, orthovoltage and low energy electrons being the most useful. Beam harding for orthovoltage beams and secondary and tertiary (skin) collimation of appropriate electron beams are critical. For more extensive and deeply invasive lesions contour-shaping through customized bolus material is essential. Equally important is the familiarity with custom shielding of critical structures, such as eyes, ears, oral cavity and central nervous system structures. Brachytherapy applications in the treatment of skin carcinomas is limited but should be considered when implants with high dose uniformity can be constructed. (3) The discussion of clinical management will start with a discussion of properties and routes of spread of the diverse

  13. Design and Analysis of Rotating Bucket Arm of Excavator

    Directory of Open Access Journals (Sweden)

    Bikash Rai

    2013-12-01

    Full Text Available In this paper an attempt has been made to design and analyze the rotating bucket of the excavator along with the stick and the bucket arm. This paper focuses on the joint design by using the geared motor for angular rotation of the bucket arm and studies the effect of digging, torsional force and bending stresses developed on the joint. Study the motion of the bucket arm

  14. Most Correlated Arms Identification

    OpenAIRE

    Liu, Che-Yu; Bubeck, Sébastien

    2014-01-01

    We study the problem of finding the most mutually correlated arms among many arms. We show that adaptive arms sampling strategies can have significant advantages over the non-adaptive uniform sampling strategy. Our proposed algorithms rely on a novel correlation estimator. The use of this accurate estimator allows us to get improved results for a wide range of problem instances.

  15. Experimental radiotherapy and clinical radiobiology. Vol. 8, special issue 1. Proceedings

    International Nuclear Information System (INIS)

    The publication contains the abstracts of all papers and posters presented at the symposium. The headings were as follows: Radiobiology of the lung, mediation of radiation damage in the lung, clinical studies, future clinical directions, as well as documentation and management. (MG)

  16. Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981

    International Nuclear Information System (INIS)

    Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once

  17. ARM Airborne Carbon Measurements (ARM-ACME) and ARM-ACME 2.5 Final Campaign Reports

    Energy Technology Data Exchange (ETDEWEB)

    Biraud, S. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Tom, M. S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sweeney, C. [NOAA Earth Systems Research Lab., Boulder, CO (United States)

    2016-01-01

    We report on a 5-year multi-institution and multi-agency airborne study of atmospheric composition and carbon cycling at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, with scientific objectives that are central to the carbon-cycle and radiative-forcing goals of the U.S. Global Change Research Program and the North American Carbon Program (NACP). The goal of these measurements is to improve understanding of 1) the carbon exchange of the Atmospheric Radiation Measurement (ARM) SGP region; 2) how CO2 and associated water and energy fluxes influence radiative-forcing, convective processes, and CO2 concentrations over the ARM SGP region, and 3) how greenhouse gases are transported on continental scales.

  18. Engaging armed non-state actors in mechanisms for protection

    Directory of Open Access Journals (Sweden)

    Pauline Lacroix

    2011-03-01

    Full Text Available Experience of engagement with armed non-state actors on the landmine ban may point the way to innovative approaches to preventing forced displacement and other abuses of human rights....

  19. 武警森林部队战士休整期心理健康状况调查%On Investigation the mental health status in the period of rest of Forest Armed Police Force

    Institute of Scientific and Technical Information of China (English)

    刘茵; 曹春霞; 任晓东; 任晓红; 王熙; 李浴峰

    2012-01-01

    [Objective] To realize the mental health status of Forest Armed Police Forces(FAPF) in the period of rest . [Methods] Multistage sampling survey methods were used to sample 1167 FAPF soldier. Symptom Checklist(SCL-90) was used to realize the psychological conditions. [Results] 1 167 soldiers in the survey, who had significant psychological problems, accounted for 4.88%. Coercion 、 hostility、 somatizatioiu、 others and interpersonal sensitivity factors had higher detection rates. SCL-90 total-sharing and the factor scores were lower than Chinese national norm and Chinese soldiers norm (P <0.01); The mental health factor of FAPF soldiers in different units were significantly different(P <0.05); low-cultural group scores were lower than high-cultural group in the total-sharing, depression, anxiety, hostility, paranoia and psychosis factor, there were statistically different(P <0.05); there was not significantly different no matter the only child soldiers、former residence before recruited and different ranks or not(P <0.05). [Conclusion] From this survey, it suggests that the general level of mental health status of FAPF in the rest period is better than that of national or soldiers norm.%[目的]了解森林部队休整期间心理健康状况.[方法]采用多阶段整群抽样调查方法,在武警森林基层部队抽取1167名战士,采用症状自评量表(Symptom Checklist,SCL-90)调查了解心理状况.[结果]1167名被调查战士中,总均分提示大于等于2分的占4.88%,10类因子中强迫、敌对、躯体化、其他、人际敏感因子有较高检出率.SCL-90总均分及各因子分均低于中国地方人群常模和中国军人常模(P<0.01);不同单位战士心理健康状况各因子得分有显著性差异(P<0.05);低文化组在总均分、抑郁、焦虑、敌对、偏执和精神病性因子得分低于高文化组,存在统计学意义(P<0.05);是否独生子、兵源地和警衔不同的战士,心理健

  20. IAEA advisory group meeting on nuclear and atomic data for radiotherapy and related radiobiology in co-operation with the Radiobiological Institute of the Division for Health Research TNO, 16-20 September 1985, Rijswijk, the Netherlands

    International Nuclear Information System (INIS)

    The IAEA Advisory Group Meeting on ''Nuclear and Atomic Data for Radiotherapy and Related Radiobiology'' was held at Rijswijk, the Netherlands, from 16 to 20 September 1985, in co-operation with the Radiobiological Institute TNO. The meeting participants reviewed the current and future requirements on nuclear and atomic data for radiotherapy and radiobiology, identified data requirements and their priorities, and issued a number of specific recommendations for future technical work in nuclear and atomic data required to establish a more solid nuclear physics foundation of radiotherapy and related radiobiology. The recommendations in this report are directed to three areas, namely beam production and field description, dosimetry, and interpretation and optimization of biological effects. The final proceedings will be issued as an IAEA publication in 1986. (author)

  1. Paul Scherrer Institut annual report 1995. Annex II: PSI life sciences and institute for medical radiobiology newsletter 1995

    International Nuclear Information System (INIS)

    The newsletter presents the 1995 progress report of PSI F2-Department and of the Institute for Medical Radiobiology in the fields of radiation medicine, radiopharmacy and radiation hygiene. figs., tabs., refs

  2. Paul Scherrer Institut annual report 1995. Annex II: PSI life sciences and institute for medical radiobiology newsletter 1995

    Energy Technology Data Exchange (ETDEWEB)

    Blaeuenstein, P.; Gschwend, B. [eds.

    1996-09-01

    The newsletter presents the 1995 progress report of PSI F2-Department and of the Institute for Medical Radiobiology in the fields of radiation medicine, radiopharmacy and radiation hygiene. figs., tabs., refs.

  3. Paul Scherrer Institut annual report 1996. Annex II: PSI life sciences and Institute for Medical Radiobiology Newsletter 1996

    International Nuclear Information System (INIS)

    This annex to the PSI Annual Report 1996 reports on the progress achieved by the PSI Department II during 1996 in the fields of radiation medicine, radiopharmacy, radiation hygiene, positron emission tomography and medical radiobiology. figs., tab., refs

  4. Activities of the radiobiological institute, the institute for experimental gerontology, and the primate center. Annual report, 1976

    International Nuclear Information System (INIS)

    Activities, presented by way of concise articles, cover the following subjects: radiation physics, radiobiology, experimental tumor therapy, tumor induction and tumor biology, immunology, transplantation and immunogenetics, hematology, gerontology, ethology, microbiology and quotobiology, techniques, and animals

  5. Dual redundant arm system operational quality measures and their applications - Dynamic measures

    Science.gov (United States)

    Lee, Sukhan; Kim, Sungbok

    1990-01-01

    Dual-arm dynamic operation quality measures are presented which quantify the efficiency and capability of generating Cartesian accelerations by two cooperative arms based on the analysis of dual-arm dynamic interactions. Dual-arm dynamic manipulability is defined as the efficiency of generating Cartesian accelerations under the dynamic and kinematic interactions between individual arms and an object under manipulation. The analysis of dual-arm dynamic interactions is based on the so-called Cartesian space agent model of an arm, which represents an individual arm as a force source acting upon a point mass with the effective Cartesian space arm dynamics and an environment or an object under manipulation. The Cartesian space agent model of an arm makes it possible to derive the dynamic and kinematic constraints involved in the transport, assembly and grasping modes of dual-arm cooperation. A task-oriented operational quality measure, (TOQd) is defined by evaluating dual-arm dynamic manipulability in terms of given task requirements. TOQd is used in dual-arm joint configuration optimization. Simulation results are shown. A complete set of forward dynamic equations for a dual-arm system is derived, and dual-arm dynamic operational quality measures for various modes of dual-arm cooperation allowing sliding contacts are established.

  6. Detecting Illegal Arms Trade

    OpenAIRE

    DellaVigna, Stefano; Ferrara, Eliana La

    2010-01-01

    Illegal arms are responsible for thousands of deaths in civil wars every year. Yet, their trade is very hard to detect. We propose a method to statistically detect illegal arms trade based on the investor knowledge embedded in financial markets. We focus on eight countries under UN arms embargo in the period 1990-2005, and analyze eighteen events during the embargo that suddenly increase or decrease conflict intensity. If the weapon-making companies are not trading or are trading legally, an ...

  7. Dual-arm generalized compliant motion with shared control

    Science.gov (United States)

    Backes, Paul G.

    1993-03-01

    A multiple arm generalized compliant motion robot control system governs dual multi-joint robot arms handling an object with both of the arms in accordance with input parameters governing plural respective behaviors to be exhibited by the robot in respective behavior spaces simultaneously. A move-squeeze decomposition processor computes actual move and squeeze decomposition forces based upon current robot force sensor outputs. A compliant motion processor transforms plural object position perturbations of the plural behaviors from the respective behavior spaces to a common space and computes a relative transformation to a behavior-commanded object position in accordance with the object position perturbations of the plural behaviors. A kinematics processor updates a transformation to a current commanded object position based upon the relative transformation to the behavior-commanded object position. A multiple arm squeeze control processor computes from appropriate squeeze force input parameters and from actual squeeze forces for each of the arms, a squeeze control position perturbation for each of the arms, to provide squeeze control. An inverse kinematics processor computes from the commanded object position transformation and from the squeeze control position perturbation, new robot joint angles, and controls respective joints of the robot arms in accordance with the new robot joint angles.

  8. Dual arm generalized compliant motion with shared control

    Science.gov (United States)

    Backes, Paul G.

    1993-03-01

    A multiple arm generalized compliant motion robot control system governs dual multi-joint robot arms handling an object with both of the arms in accordance with input parameters governing plural respective behaviors to be exhibited by the robot in respective behavior spaces simultaneously. A move-squeeze decomposition processor computes actual move and squeeze decomposition forces based upon current robot force sensor outputs. A compliant motion processor transforms plural object position perturbations of the plural behaviors from the respective behavior spaces to a common space and computes a relative transformation to a behavior-commanded object position in accordance with the object position perturbations of the plural behaviors. A kinematics processor updates a transformation to a current commanded object position based upon the relative transformation to the behavior-commanded object position. A multiple arm squeeze control processor computes from appropriate squeeze force input parameters and from actual squeeze forces for each of the arms, a squeeze control position perturbation for each of the arms, to provide squeeze control. An inverse kinematics processor computes from the commanded object position transformation and from the squeeze control position perturbation, new robot joint angles, and controls respective joints of the robot arms in accordance with the new robot joint angles.

  9. VI Congress on radiation research (radiobiology, radioecology, radiation safety). Abstracts. Volume 1 (sections I-VII)

    International Nuclear Information System (INIS)

    The collection contains abstracts at the VI Congress on radiation studies, a program that included various aspects of the action of ionizing and non-ionizing radiation on living organisms, problems of radioecology and radiation safety of human health and environment. Congress is confined to the 25th anniversary of the accident at the Chernobyl NPP. Several reports have summarized the 25-years studying the effects of the accident, articulated forecasts and the main directions of further research. The first volume contains the plenary reports, presentations on the sections of radiation biochemistry and molecular radiobiology, radiation genetics, radiation immunology and hematology, medical and biological aspects of radiation effect, mechanisms of low dose and low intensity radiation effects, long-term effects of radiation. Radiation protection and modification of radiation effects, radiobiology of tumors, problems of radiation therapy are under consideration

  10. Radiobiological effects in small mammals populations dwelled at radioactive waste disposal sites

    International Nuclear Information System (INIS)

    A major issue in evaluating the ecological acceptability of a disposal system for radioactive waste is in preventing the ecological risk that may arise from exposures in the distant future. There is uncertainty surrounding any estimate of these doses or risks due to lack of knowledge about future conditions. Therefore, the adequate estimation of the ecological acceptability of a radioactive waste disposal system required a complex radioecological and radiobiological approach. Environmental surveillance at the Sergievo-Posadsky radioactive waste disposal system of the Scientific and Industrial Association Radon in additional to a standard complex radiological testing includes also the study of the radiobiological effects in different biological objects sampled from the contaminated areas. In present report the results obtained on small rodents (mice and voles) sampled from the strict mode and fence zones of this disposal system are displayed and discussed. (author)

  11. Two-arm master/slave manipulator for nuclear facilities

    International Nuclear Information System (INIS)

    Several kinds of one-arm manipulators have been developed for remote maintenance in nuclear facilities to reduce personnel radiation exposure and to keep plant availability as high as possible. In those maintenance tasks, however, there are many that need two arms, e.g., one arm holds the work object and the other arm cuts it with a plasma torch. To answer this need, a dexterous two-arm master/slave manipulator has been developed based on the technology for one-arm manipulators. A prototype two-arm/slave manipulator is shown. The specifications for master and slave manipulators are listed. The prototype two-arm manipulator is undergoing laboratory performance tests. Preliminary results showed the maximum static operating forces were 0.4 N for the all-direct drive (DD)-type arm and 1.1 N for the semi-DD type. The payload for each arm of the slave manipulator was confirmed as 10 kgf, using mock pieces. The decommissioning tasks of cutting pipes and steel plates were successfully carried out

  12. Ill-posed problem and regularization in reconstruction of radiobiological parameters from serial tumor imaging data

    International Nuclear Information System (INIS)

    The main objective of this article is to improve the stability of reconstruction algorithms for estimation of radiobiological parameters using serial tumor imaging data acquired during radiation therapy. Serial images of tumor response to radiation therapy represent a complex summation of several exponential processes as treatment induced cell inactivation, tumor growth rates, and the rate of cell loss. Accurate assessment of treatment response would require separation of these processes because they define radiobiological determinants of treatment response and, correspondingly, tumor control probability. However, the estimation of radiobiological parameters using imaging data can be considered an inverse ill-posed problem because a sum of several exponentials would produce the Fredholm integral equation of the first kind which is ill posed. Therefore, the stability of reconstruction of radiobiological parameters presents a problem even for the simplest models of tumor response. To study stability of the parameter reconstruction problem, we used a set of serial CT imaging data for head and neck cancer and a simplest case of a two-level cell population model of tumor response. Inverse reconstruction was performed using a simulated annealing algorithm to minimize a least squared objective function. Results show that the reconstructed values of cell surviving fractions and cell doubling time exhibit significant nonphysical fluctuations if no stabilization algorithms are applied. However, after applying a stabilization algorithm based on variational regularization, the reconstruction produces statistical distributions for survival fractions and doubling time that are comparable to published in vitro data. This algorithm is an advance over our previous work where only cell surviving fractions were reconstructed. We conclude that variational regularization allows for an increase in the number of free parameters in our model which enables development of more

  13. Radiobiological work using a negative pion beam at the Rutherford Laboratory 1971-76

    International Nuclear Information System (INIS)

    The subject is discussed in two sections: physics experiments (including, inter alia, dose measurement, LET distribution, radiation products of spallation); radiobiological studies (including separate reports as follows: review of experimental programme; some in vivo effects of negative pions in mice; survival and recovery of Hela cells in vitro; negative pion dose-response curves for frozen Hela cells; response of vicia faba to irradiation with negative pions; pion experiments with chromosome aberrations). (U.K.)

  14. Radiobiological investigations of the accelerators at the Joint Institute for Nuclear Research

    International Nuclear Information System (INIS)

    Full text: The Joint Institute for Nuclear Research (JINR) has the different accelerators of heavy charged particles for various energies. The radiobiological investigations at these machines have been commenced some tens years ago. The main task of scientific research at the Laboratory of Radiation Biology of JINR is connected with investigations of genetic effects of accelerated charged particles with wide spectrum of energies. Using accelerated heavy ions with low energy, the following directions of researches in radiobiology and radiation genetics were performed: study of RBE problem in connection with DNA repair processes; investigation of the molecular mechanisms of point and structural mutation induction in prokaryotic cells and the influence of the repair systems on the mutagenic processes after irradiation in a wide range of linear energy transfer (LET); study of the SOS-response of bacterial cells by using SOS-chromo test, SOS-lux test and by criteria of α-prophage induction in lysogenic bacteria after irradiation by heavy ions; study of the regularities of gene mutation inductions in yeast cells under action of ionizing radiation with different LET; investigations of the regularities of unstable and stable chromosomal aberrations (translocations) in human cells under action of ionizing radiation with wide LET range; study of mutagenic (HPRT gene) effects in mammalian cells in culture after heavy charged particle irradiation and chromosomal instability in HPRT-mutant clones after irradiation; study of the cytogenetic effects in mammalian cells irradiated by heavy ions in low doses. The radiobiological investigations with high energy are carried out at the Nuclotron - the new JINR accelerator. The programme involves the most vital tasks of modern radiobiology: study of the regularities and mechanisms of stable and unstable chromosome aberration induction in human cells; genetic control of check-point regulation in low eukaryotic cells; study of the

  15. Radiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans

    OpenAIRE

    Liang, X.; Penagaricano, J.; Zheng, D.; Morrill, S.; Zhang, X; Corry, P.; Griffin, R. J.; Han, E. Y.; Hardee, M.; Ratanatharathom, V.

    2016-01-01

    Background The aim of this study is to evaluate the radiobiological impact of Acuros XB (AXB) vs. Anisotropic Analytic Algorithm (AAA) dose calculation algorithms in combined dose-volume and biological optimized IMRT plans of SBRT treatments for non-small-cell lung cancer (NSCLC) patients. Methods Twenty eight patients with NSCLC previously treated SBRT were re-planned using Varian Eclipse (V11) with combined dose-volume and biological optimization IMRT sliding window technique. The total dos...

  16. Installation of a flow cytometry facility and some applications in radiobiology

    International Nuclear Information System (INIS)

    Flow cytometry has enormous potential in many areas of experimental pathology. Details of the installation and commissioning of a flow cytometer at the Harwell Laboratory are described. Following an explanation of the principles of flow cytometry, several applications to specific problems in radiobiology are discussed. Also included are results of some preliminary studies with the Harwell flow cytometer on samples such as blood, bone marrow, macrophages and cell cultures, and a discussion of future applications. (author)

  17. A community call for a dedicated radiobiological research facility to support particle beam cancer therapy

    DEFF Research Database (Denmark)

    Holzscheiter, Michael H.; Bassler, Niels; Dosanjh, Manjit;

    2012-01-01

    Recently more than one hundred researchers followed an invitation to a brainstorming meeting on the topic of a future dedicated radio-biological and radio-physical research center. 100 more joint the meeting via webcast. After a day of presentations and discussions it was clear, that an urgent ne...... for such a development exists, resulting in a community call for the construction of a dedicated laboratory. Below we comment on the essential points....

  18. [From microdosimetry to nanodosimetry--the link between radiobiology and radiation physics].

    Science.gov (United States)

    Fu, Yuchuan; Li, Ping

    2014-06-01

    The link between micro- and macro-parameters for radiation interactions that take place in living biological systems is described in this paper. Meanwhile recent progress and development in microdosimetry and nanodosimetry are introduced, including the methods to measure and calculate these micro- or nano-parameters. The relationship between radiobiology and physical quantities in microdosimetry and nanodosimetry was presented. Both the current problems on their applications in radiation protection and radiotherapy and the future development direction are proposed. PMID:25219261

  19. The impact of modeling nuclear fragmentation on delivered dose and radiobiology in ion therapy

    International Nuclear Information System (INIS)

    The importance of nuclear interactions for ion therapy arises from the influence of the particle spectrum on, first, radiobiology and therefore also on treatment planning, second, the accuracy of measuring dose and, third, the delivered dose distribution. This study tries to determine the qualitative as well as the quantitative influence of the modeling of inelastic nuclear interactions on ion therapy. Thereby, three key disciplines are investigated, namely dose delivery, dose assessment and radiobiology. In order to perform a quantitative analysis, a relative comparison between six different descriptions of nuclear interactions is carried out for carbon ions. The particle transport is simulated with the Monte Carlo code SHIELD-HIT10A while dose planning and radiobiology are covered by the analytic treatment planning program for particles TRiP, which determines the relative biological effectiveness (RBE) with the local effect model. The obtained results show that the physical dose distribution can in principle be significantly influenced by the modeling of fragmentation (about 10% for a 20% change in all inelastic nuclear cross sections for a target volume ranging from 15 to 25 cm). While the impact of nuclear fragmentation on stopping power ratios can be neglected, the fluence correction factor may be influenced by the applied nuclear models. In contrast to the results for the physical dose, the variation of the RBE is only small (about 1% for a 20% change in all inelastic nuclear cross sections) suggesting a relatively weak dependence of radiobiology on the detailed composition of the particle energy spectrum of the mixed radiation field. Also, no significant change (about 0.2 mm) of the lateral penumbra of the RBE-weighted dose is observed. (paper)

  20. Heavy Charged Particle Radiobiology: Using Enhanced Biological Effectiveness and Improved Beam Focusing to Advance Cancer Therapy

    OpenAIRE

    Allen, Christopher; Borak, Thomas B.; Tsujii, Hirohiko; Jac A Nickoloff

    2011-01-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilitie...

  1. Ill-posed problem and regularization in reconstruction of radiobiological parameters from serial tumor imaging data

    Science.gov (United States)

    Chvetsov, Alevei V.; Sandison, George A.; Schwartz, Jeffrey L.; Rengan, Ramesh

    2015-11-01

    The main objective of this article is to improve the stability of reconstruction algorithms for estimation of radiobiological parameters using serial tumor imaging data acquired during radiation therapy. Serial images of tumor response to radiation therapy represent a complex summation of several exponential processes as treatment induced cell inactivation, tumor growth rates, and the rate of cell loss. Accurate assessment of treatment response would require separation of these processes because they define radiobiological determinants of treatment response and, correspondingly, tumor control probability. However, the estimation of radiobiological parameters using imaging data can be considered an inverse ill-posed problem because a sum of several exponentials would produce the Fredholm integral equation of the first kind which is ill posed. Therefore, the stability of reconstruction of radiobiological parameters presents a problem even for the simplest models of tumor response. To study stability of the parameter reconstruction problem, we used a set of serial CT imaging data for head and neck cancer and a simplest case of a two-level cell population model of tumor response. Inverse reconstruction was performed using a simulated annealing algorithm to minimize a least squared objective function. Results show that the reconstructed values of cell surviving fractions and cell doubling time exhibit significant nonphysical fluctuations if no stabilization algorithms are applied. However, after applying a stabilization algorithm based on variational regularization, the reconstruction produces statistical distributions for survival fractions and doubling time that are comparable to published in vitro data. This algorithm is an advance over our previous work where only cell surviving fractions were reconstructed. We conclude that variational regularization allows for an increase in the number of free parameters in our model which enables development of more

  2. Further Radiobiologic Modeling of Palliative Radiotherapy: Use of Virtual Trials

    International Nuclear Information System (INIS)

    Purpose: To study duration of response in palliative radiotherapy in a population of tumors. Methods and Materials: Models of dynamic changes in cell number with time were used to develop a function for the remission time (Trem) after palliative radiotherapy: Trem=(BED)/K -t1(1+(α.K)/z ), where BED is the biologically effective dose, t1 the duration of symptoms (i.e., the time between the onset of symptoms and the initiation of radiotherapy), K the daily BED repopulation equivalent, α the linear radiosensitivity parameter in the linear-quadratic model, and z the tumor regression rate. Results: Simulations of clinical trials show marked variations in remission statistics depending on the tumor characteristics and are highly compatible with the results of clinical trials. Dose escalation produces both a higher proportion and extended duration of remissions, especially in tumors with high α/β ratios and K values, but the predicted dose responses of acute and late side effects show that caution is necessary. The prospect of using particle beam therapy to reduce normal tissue radiation exposures or using hypoxic sensitizers to improve the tumor cell kill might significantly improve the results of palliative radiotherapy in carefully selected patients and could also be used for safer palliative re-treatments in patients with the potential for prolonged survival. The effect of tumor heterogeneity in determining palliative responses probably exceeds that in radical radiotherapy; as few as 100 patients in each treatment arm produce statistically unreliable results. Conclusions: Virtual trials of palliative radiotherapy can be useful to test the effects of competing schedules and better determine future strategies, including improved design of clinical trials as well as combinations of radiotherapy with other anticancer modalities

  3. Fast neutrons set the pace. [Radiobiological investigations with fast neutrons at the CSIR cyclotron in Pretoria

    Energy Technology Data Exchange (ETDEWEB)

    Hough, J.H.; Slabbert, J.P. (Council for Scientific and Industrial Research, Pretoria (South Africa). National Accelerator Centre)

    1985-01-01

    Radiobiological investigations with fast neutrons have been initiated at the CSIR cyclotron in Pretoria. It was proposed some years ago to create a neutron therapy facility using the CSIR cyclotron. Neutrons are classified as high linear energy transfer (LET) particles. Biological damage occurring in tissue is a direct function of the LET of the incident radiation. To quantify the biological effects of different types of radiation on mammalian cells, several procedures and concepts have evolved from radiobiological research. Probably the most significant laboratory techniques developed, were the derivation of cell survival curves which are obtained by determining the number of cell colonies that have survived a certain radiation dose. A semi-logarithmic plot of surviving fraction versus the absorbed dose yields the survival curve. Dose modifying factors such as the relative biological effectiveness (RBE) of the radiation can be quantified in terms of this relationship. A radiobiological programme has to be undertaken before patients can receive neutron therapy at the CSIR cyclotron. The article is a discussion of this programme.

  4. The European Radiobiology Archives (ERA) - Content, structure and use illustrated by an example

    International Nuclear Information System (INIS)

    The European Radiobiology Archives (ERA), supported by the European Commission and the European Late Effect Project Group (EULEP), together with the US National Radiobiology Archives (NRA) and the Japanese Radiobiology Archives (JRA) have collected all information still available on long-term animal experiments, including some selected human studies. The archives consist of a database in Microsoft Access, a web site, databases of references and information on the use of the database. At present, the archives contain a description of the exposure conditions, animal strains, etc. from ∼350,000 individuals; data on survival and pathology are available from ∼200,000 individuals. Care has been taken to render pathological diagnoses compatible among different studies and to allow the lumping of pathological diagnoses into more general classes. 'Forms' in Access with an underlying computer code facilitate the use of the database. This paper describes the structure and content of the archives and illustrates an example for a possible analysis of such data. (authors)

  5. ARM Mentor Selection Process

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, D. L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-10-01

    The Atmospheric Radiation Measurement (ARM) Program was created in 1989 with funding from the U.S. Department of Energy (DOE) to develop several highly instrumented ground stations to study cloud formation processes and their influence on radiative transfer. In 2003, the ARM Program became a national scientific user facility, known as the ARM Climate Research Facility. This scientific infrastructure provides for fixed sites, mobile facilities, an aerial facility, and a data archive available for use by scientists worldwide through the ARM Climate Research Facility—a scientific user facility. The ARM Climate Research Facility currently operates more than 300 instrument systems that provide ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as lead mentors. Lead mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They must also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets. The ARM Climate Research Facility is seeking the best overall qualified candidate who can fulfill lead mentor requirements in a timely manner.

  6. Managing new arms races

    International Nuclear Information System (INIS)

    The management of new arms races in the region of Asia-Pacific includes considerations of weapons trade and transfer in the region, with an emphasis on nuclear weapons proliferation. It deals with the problem of controlling the arms trade and the efforts to control conventional weapons and underlines the possible role and influence of Conference on Cooperation and Security in Europe (CSCE)

  7. Increased Force Variability in Chronic Stroke: Contributions of Force Modulation below 1 Hz

    OpenAIRE

    Lodha, Neha; Misra, Gaurav; Coombes, Stephen A.; Evangelos A Christou; James H Cauraugh

    2013-01-01

    Increased force variability constitutes a hallmark of arm disabilities following stroke. Force variability is related to the modulation of force below 1 Hz in healthy young and older adults. However, whether the increased force variability observed post stroke is related to the modulation of force below 1 Hz remains unknown. Thus, the purpose of this study was to compare force modulation below 1 Hz in chronic stroke and age-matched healthy individuals. Both stroke and control individuals (N =...

  8. Chapitre VIII. Le commerce des armes

    OpenAIRE

    Gasteyger, Curt

    2015-01-01

    Si nous ne vendons pas d’armes, quelqu’un d’autre le fera à notre placeUn homme politique américain, soviétique, français ou anglais Une croissance phénoménale Les dépenses d’armement et la taille des forces armées augmentent plus rapidement dans les pays en voie de développement que dans le monde industriel. Pendant la décennie 1973-1982, les armées des pays du Sud se sont accrues de 2 538 000 hommes (la Chine étant comprise), alors que les effectifs de celles du Nord, avec une addition de 3...

  9. Hearing Protection Evaluation for the Combat Arms Earplug at Idaho National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    James Lovejoy

    2007-03-01

    The Idaho National Laboratory (INL) is managed by Battelle Energy Alliance, LLC (BEA) for the Department of Energy. The INL Protective Security Forces (Pro Force) are involved in training exercises that generate impulse noise by small arms fire. Force-on-force (FOF) training exercises that simulate real world scenarios require the Pro Force to engage the opposition force (OPFOR) while maintaining situational awareness through verbal communications. The Combat Arms earplug was studied to determine if it provides adequate hearing protection in accordance with the requirements of MIL-STD-1474C/D. The Combat Arms earplug uses a design that allows continuous noise through a critical orifice while effectively attenuating high-energy impulse noise. The earplug attenuates noise on a non linear scale, as the sound increases the attenuation increases. The INL studied the effectiveness of the Combat Arms earplug with a Bruel & Kjaer (B&K) head and torso simulator used with a selection of small arms to create impulse sound pressures. The Combat Arms earplugs were inserted into the B&K head and torso ears, and small arms were then discharged to generate the impulse noise. The INL analysis of the data indicates that the Combat Arms earplug does provide adequate protection, in accordance with MIL-STD-1474C/D, when used to protect against impulse noise generated by small arms fire using blank ammunition. Impulse noise generated by small arms fire ranged from 135–160 dB range unfiltered un-weighted. The Combat Arms earplug attenuated the sound pressure 10–25 dB depending on the impulse noise pressure. This assessment is consistent with the results of previously published studies on the Combat Arms earplug (see Section 5, “References”). Based upon these result, the INL intends to use the Combat Arms earplug for FOF training exercises.

  10. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  11. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available   Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  12. Revising the Radiobiological Model of Synchronous Chemotherapy in Head-and-Neck Cancer: A New Analysis Examining Reduced Weighting of Accelerated Repopulation

    International Nuclear Information System (INIS)

    Purpose: Previous studies of synchronous chemoradiation therapy have modeled the additional effect of chemotherapy as additional radiation therapy biologically effective dose (BED). Recent trials of accelerated versus conventional fractionation chemoradiation have cast doubt on such modeling. The purpose of this study was to identify alternative models. Methods and Materials: Nine trials of platinum-based chemoradiation were identified. In radiation therapy-alone arms, the radiation therapy BED for tumor was calculated using standard parameters. In chemoradiation arms, 3 methods were used to calculate tumor BED (tBED): additional BED, addition of 9.3 Gy BED for tumor to the radiation therapy BED; zero repopulation, BED with no correction for repopulation; variable tp (the average doubling time during accelerated repopulation), values of tp 3-10 were used to examine a partial suppression of repopulation. The correlations between the calculated percentage change in tBED for each method and observed percentage change in local control were assessed using the Pearson product moment correlation. Results: Significant correlations were obtained for all 3 methods but were stronger with zero repopulation (P=.0002) and variable tp (tp = 10) (P=.0005) than additional BED (P=.02). Conclusions: Radiobiological models using modified parameters for accelerated repopulation seem to correlate strongly with outcome in chemoradiation studies. The variable tp method shows strong correlation for outcome in local control and is potentially a more suitable model in the chemoradiation setting. However, a lack of trials with an overall treatment time of more than 46 days inhibits further differentiation of the optimal model

  13. Contralateral manual compensation for velocity-dependent force perturbations

    OpenAIRE

    Jackson, Carl P. T.; Miall, R. Chris

    2007-01-01

    It is not yet clear how the temporal structure of a voluntary action is coded allowing coordinated bimanual responses. This study focuses on the adaptation to and compensation for a force profile presented to one stationary arm which is proportional to the velocity of the other moving arm. We hypothesised that subjects would exhibit predictive coordinative responses which would co-vary with the state of the moving arm. Our null hypothesis is that they develop a time-dependent template of forc...

  14. ARM7-kehityskortti

    OpenAIRE

    Kukkonen, Henri

    2006-01-01

    Tämän opinnäytetyön tarkoituksena oli suunnitella ja toteuttaa ARM-mikro-ohjain pohjainen kehityskortti. Kortin tuli olla soveltuva ARM-ohjelmoinnin opettamiseen. Työssä myös selvitettiin ARM-mikro-ohjaimen ohjelmointiympäristön käyttöönotto. Teoriaosassa käsitellään ARM-arkkitehtuuria, työssä käytettyjen Atmelin AT91R40008-mikro-ohjaimen sekä Philipsin LPC2105-mikro-ohjaimen ominaisuuksia. Erityisesti työssä keskitytään kehityskorttien suunnitteluun. Kehityskortin vaatimuksina oli, että se ...

  15. ARM for Platform Application

    Science.gov (United States)

    Patte, Mathieu; Poupat, Jean-Luc; Le Meur, Patrick

    2015-09-01

    The activities described in this paper are part of the CNES R&T “Study of a Cortex-R ARM based architecture” performed by Airbus DS Space System & Electronics in 2014. With the support of CNES, Airbus DS has performed the porting of a representative space application software on an ARM based demonstration platform. This paper presents the platform itself, the activities performed at software level and the first results on this evaluation study.

  16. Design and Implementation of Telemedicine Net Platform by Using the Armed Police Forces' Video Conferencing System%依托武警部队视频会议系统的远程医学网平台设计与实现

    Institute of Scientific and Technical Information of China (English)

    温剑; 胡永峰

    2011-01-01

    Objective To promote the telemedicine by using the computer technology and the modern communications technology in order to improve the remote areas officers' medical service support in ihe Armed Police Forces. Methods Distance medical nets hardware platform of the Level 3 distance medical center network was build which relies on the Armed Police Forces video conferencing system and the questions around the technical framework, the mean characteristics and the key technology were explained. Results The video conferencing system was use to build a telemedicine net hardware platform which would help to promote the telemedicine consultation. CnnrJiurinn Telemedicine service based on ihe present video conferencing system improves the army's medical support ability.[Chinese Medical Equipment Journal,2011 ,32(10) ? 70-71]%目的:利用计算机技术与现代通讯技术开展远程医学,进一步改善武警部队边远地区官兵的医疗卫勤保障.方法:依托武警部队视频会议系统构建三级远程医学中心组网的远程医学网硬件平台,并对平台设计与实施过程中的技术架构、主要特点、关键技术等若干问题进行分析.结果:能够实现依托视频会议系统,建成远程医学网硬件平台,开展远程医学会诊.结论:通过现有的视频会议系统,开展远程医疗服务,提高部队卫勤保障能力.

  17. Documenting the Effects of Armed Conflict on Population Health.

    Science.gov (United States)

    Levy, Barry S; Sidel, Victor W

    2016-01-01

    War and other forms of armed conflict have profound adverse effects on population health. It is important to document these effects to inform the general public and policy makers about the consequences of armed conflict, provide services to meet the needs of affected populations, protect human rights and document violations of international humanitarian law, and help to prevent future armed conflict. Documentation can be accomplished with surveillance, epidemiological surveys, and rapid assessment. Challenges include inadequate or absent data systems, social breakdown, forced migration, reporting biases, and the fog of war. The adverse effects of the Iraq War on population health demonstrate how the effects of armed conflict on population health can be documented. We recommend the establishment of an independent mechanism, operated by the United Nations or a multilateral organization, to investigate and document the effects of armed conflict on population health. PMID:26989827

  18. Strategic forces briefing

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  19. Hello to Arms

    Science.gov (United States)

    2005-01-01

    This image highlights the hidden spiral arms (blue) that were discovered around the nearby galaxy NGC 4625 by the ultraviolet eyes of NASA's Galaxy Evolution Explorer. The image is composed of ultraviolet and visible-light data, from the Galaxy Evolution Explorer and the California Institute of Technology's Digitized Sky Survey, respectively. Near-ultraviolet light is colored green; far-ultraviolet light is colored blue; and optical light is colored red. As the image demonstrates, the lengthy spiral arms are nearly invisible when viewed in optical light while bright in ultraviolet. This is because they are bustling with hot, newborn stars that radiate primarily ultraviolet light. The youthful arms are also very long, stretching out to a distance four times the size of the galaxy's core. They are part of the largest ultraviolet galactic disk discovered so far. Located 31 million light-years away in the constellation Canes Venatici, NGC 4625 is the closest galaxy ever seen with such a young halo of arms. It is slightly smaller than our Milky Way, both in size and mass. However, the fact that this galaxy's disk is forming stars very actively suggests that it might evolve into a more massive and mature galaxy resembling our own. The armless companion galaxy seen below NGC 4625 is called NGC 4618. Astronomers do not know why it lacks arms but speculate that it may have triggered the development of arms in NGC 4625.

  20. Planar Robot Arm Modelling and Control

    OpenAIRE

    Hernández González, Francisco

    2012-01-01

    The thesis objective is to model a one link robotic arm mounted on a sliding mobile platform and to investigate different control strategies under the effect of gravity and external force disturbance. For simplicity the robotic set up can be modelled and controlled as an inverted pendulum moving on a non constant sloping surface. Firstly the control is done on level ground. This lower mathematical complexity will be taken as an advantage to approach the analysis on aspects more related with c...

  1. Dual redundant arm system operational quality measures and their applications - Static measures

    Science.gov (United States)

    Lee, Sukhan; Kim, Sungbok

    1990-01-01

    The authors present dual-arm system static operational quality measures which quantify the efficiency and capability of a dual-arm system in generating Cartesian velocities and static forces. First, they define and analyze the kinematic interactions between the two arms incurred by the various modes of dual-arm cooperation, such as transport, assembly, and grasping modes of cooperation, and specify the kinematic constraints imposed on individual arms in Cartesian space due to the kinematic interactions. Dual-arm static manipulability is presented. Finally, dual-arm operational quality is scaled by a task-oriented operational quality measure (TOQs) obtained by the comparison between the desired and actual static manipulabilities. TOQs is used in the optimization of dual-arm joint configurations. Simulation results are shown.

  2. Development of a compact laser-produced plasma soft X-ray source for radiobiology experiments

    Science.gov (United States)

    Adjei, Daniel; Ayele, Mesfin Getachew; Wachulak, Przemyslaw; Bartnik, Andrzej; Wegrzynski, Łukasz; Fiedorowicz, Henryk; Vyšín, Luděk; Wiechec, Anna; Lekki, Janusz; Kwiatek, Wojciech M.; Pina, Ladislav; Davídková, Marie; Juha, Libor

    2015-12-01

    A desk-top laser-produced plasma (LPP) source of soft X-rays (SXR) has been developed for radiobiology research. The source is based on a double-stream gas puff target, irradiated with the focused beam of a commercial Nd:YAG laser. The source has been optimized to get a maximum photon emission from LPP in the X-ray "water window" spectral wavelength range from 2.3 nm (i.e., an absorption edge of oxygen) to 4.4 nm (i.e., an absorption edge of carbon) (280-540 eV in photon energy units) by using argon gas-puff target and spectral filtering by free-standing thin foils. The present source delivers nanosecond pulses of soft X-rays at a fluence of about 4.2 × 103 photons/μm2/pulse on a sample placed inside the vacuum chamber. In this paper, the source design, radiation output characterization measurements and initial irradiation experiments are described. The source can be useful in addressing observations related to biomolecular, cellular and organisms' sensitivity to pulsed radiation in the "water window", where carbon atoms absorb X-rays more strongly than the oxygen, mostly present in water. The combination of the SXR source and the radiobiology irradiation layout, reported in this article, make possible a systematic investigation of relationships between direct and indirect action of ionizing radiation, an increase of a local dose in carbon-rich compartments of the cell (e.g., lipid membranes), an experimental estimation of a particular role of the Auger effect (in particular in carbon atoms) in the damage to biological systems, and the study of ionization/excitation-density (LET - Linear Energy Transfer) and dose-rate effects in radiobiology.

  3. Estimation of Radiobiologic Parameters and Equivalent Radiation Dose of Cytotoxic Chemotherapy in Malignant Glioma

    International Nuclear Information System (INIS)

    Purpose: To determine the radiobiologic parameters for high-grade gliomas. Methods and Materials: The biologic effective dose concept is used to estimate the α/β ratio and K (dose equivalent for tumor repopulation/d) for high-grade glioma patients treated in a randomized fractionation trial. The equivalent radiation dose of temozolomide (Temodar) chemotherapy was estimated from another randomized study. The method assumes that the radiotherapy biologic effective dose is proportional to the adjusted radiotherapy survival duration of high-grade glioma patients. Results: The median tumor α/β and K estimate is 9.32 Gy and 0.23 Gy/d, respectively. Using the published surviving fraction after 2-Gy exposure (SF2) data, and the above α/β ratio, the estimated median α value was 0.077 Gy-1, β was 0.009 Gy-2, and the cellular doubling time was 39.5 days. The median equivalent biologic effective dose of temozolomide was 11.03 Gy9.3 (equivalent to a radiation dose of 9.1 Gy given in 2-Gy fractions). Random sampling trial simulations based on a cure threshold of 70 Gy in high-grade gliomas have shown the potential increase in tumor cure with dose escalation. Partial elimination of hypoxic cells (by chemical hypoxic cell sensitizers or carbon ion therapy) has suggested that considerable gains in tumor control, which are further supplemented by temozolomide, are achievable. Conclusion: The radiobiologic parameters for human high-grade gliomas can be estimated from clinical trials and could be used to inform future clinical trials, particularly combined modality treatments with newer forms of radiotherapy. Other incurable cancers should be studied using similar radiobiologic analysis

  4. SU-E-T-194: From Dicom-RT to Radiobiological Dose Metrics in 5 Minutes

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, B; Holloway, L

    2014-06-01

    Purpose: To develop a flexible and standalone framework for batch calculation of radiobiological dose metrics from Dicom-RT. Methods: Software has been developed which allows (1) The calculation of DVH data from DICOM dose and structure files (DVHgenerator), (2) Calculation of a wide range of radiobiological metrics from this data (CompPlanGui). Both these tools are run via graphical user interface (GUI), making them fast and simple. Part 1 is a new tool which has not previously been published, whilst part 2 is a GUI overlay for the previously published software ‘Comp-Plan’ (Holloway et. al., Medical Dosimetry, 2012), previously reliant on command line interface. The time taken for an experienced user to evaluate a test case of 6 plans with and without CompPlanGUI was quantified. Results: The DVH-generator has been found to be faster, more robust and require far less physical memory then using alternative software solutions for the same purpose. The Comp Plan GUI significantly reduces the amount of time required to set up a base directory, eliminates code crashes arising from typographical errors, and renders the code far more accessible to non-expert users. It took an experienced user of the code around 3 minutes to set up a base directory of 6 plans compared around 8 minutes without, indicating that using CompPlanGUI reduced setup time by over 50%. Conclusion: A standalone GUI based framework has developed which allows for the batch calculation of radiobiological dose metrics directly from Dicom-RT files. As with the original code, this work will be made freely available on request, as well as via matlab file exchange.

  5. SU-E-T-194: From Dicom-RT to Radiobiological Dose Metrics in 5 Minutes

    International Nuclear Information System (INIS)

    Purpose: To develop a flexible and standalone framework for batch calculation of radiobiological dose metrics from Dicom-RT. Methods: Software has been developed which allows (1) The calculation of DVH data from DICOM dose and structure files (DVHgenerator), (2) Calculation of a wide range of radiobiological metrics from this data (CompPlanGui). Both these tools are run via graphical user interface (GUI), making them fast and simple. Part 1 is a new tool which has not previously been published, whilst part 2 is a GUI overlay for the previously published software ‘Comp-Plan’ (Holloway et. al., Medical Dosimetry, 2012), previously reliant on command line interface. The time taken for an experienced user to evaluate a test case of 6 plans with and without CompPlanGUI was quantified. Results: The DVH-generator has been found to be faster, more robust and require far less physical memory then using alternative software solutions for the same purpose. The Comp Plan GUI significantly reduces the amount of time required to set up a base directory, eliminates code crashes arising from typographical errors, and renders the code far more accessible to non-expert users. It took an experienced user of the code around 3 minutes to set up a base directory of 6 plans compared around 8 minutes without, indicating that using CompPlanGUI reduced setup time by over 50%. Conclusion: A standalone GUI based framework has developed which allows for the batch calculation of radiobiological dose metrics directly from Dicom-RT files. As with the original code, this work will be made freely available on request, as well as via matlab file exchange

  6. Report on the behalf of Commission for National Defence and Armed Forces on the bill project (nr 1365) aiming at strengthening conditions of access to nuclear base installations (INB). Nr 2527

    International Nuclear Information System (INIS)

    This report first outlines that nuclear installations are subject to illegal intrusions which challenge their safety and security. It outlines that these installations are extremely sensitive and particularly threatened (the energy sector, as a key sector, is submitted to a specific regulation, and threats are potentially serious), that, beyond the terrorist threat and the risk of sabotage, nuclear installations are regularly facing other illegal behaviours (illegal intrusions are a recurrent issue, and drones are emerging as a new kind of threat), that the protection of nuclear installations is carried out by forces dedicated to this mission (a specialised military force for EDF sites, civil forces for the CEA and Areva, the role of the French Air Force to protect airspace), and that recent legal advances must be deepened. The second part outlines that the present legal protection framework in inadequate and incomplete. The French legal regime is presented and some foreign examples are evoked, and the need of creation of a specific penal regime is outlined. The general discussion and the discussion of the bill project articles are reported. A table proposes a comparative overview between the existing arrangement, the bill project text, and the Commission's text

  7. Controlling radioactive waste disposal: the work of the Fisheries Radiobiological Laboratory

    International Nuclear Information System (INIS)

    The Fisheries Radiobiological Laboratory (FRL) is based at Lowestoft and forms the Aquatic Environment Protection Division 1, within the Directorate of Fisheries Research of the Ministry of Agriculture, Fisheries and Food. The FRL undertakes a range of duties throughout the UK, and is primarily concerned with liquid wastes to the sea, and surface waters and solid wastes dumped at sea. Summaries are given of the work, responsibilities and interests of the three groups within FRL (Radiological Control, Research and Supporting Services). (U.K.)

  8. Physical and cellular radiobiological properties of heavy ions in relation to cancer therapy applications

    International Nuclear Information System (INIS)

    A variety of experiments have been carried out in vitro on several mammalian cell lines with carbon, neon, silicon and argon beams at 14 and 24 cm depth penetration. The results of these experiments substantiate the conceptual basis for physical and radiobiological advantages of accelerated heavy-ion beams in cancer therapy. The best biologically effective depth dose ratio for situations corresponding to therapy needs can be obtained with accelerated carbon beams. The depression of the oxygen effect with silicon or argon ion beams is greater than that achievable with neutrons or pions, or with heavy ions of lower atomic number

  9. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 22. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Cordes, Nils; Dikomey, Ekkehard; Krause, Mechthild; Petersen, Cordula; Rodemannn, H. Peter; Zips, Daniel (eds.)

    2013-03-01

    The proceedings of the 22th Symposium on experimental radiotherapy and clinical radiotherapy contain lectures and poster on the following issues: Radiation induced immuno-targeting of tumors; targeting in the radiotherapy; biomarkers; targeting; radio-oncological therapy of rectal carcinoma - contribution of radiobiology for therapy optimization; biomarkers for radiation sensibility; resistance mechanisms of tumors; resistance mechanisms of normal tissue; micro ambience, P13L inhibition in radiotherapy: improvement of the local tumor control by molecular mechanisms or the influence of the tumor micro-ambience? DNA repair; radiation effects and technical development.

  10. Radiobiological and radioecological studies with the unicellular marine algae Acetabularia, Batophora and Dunaliella

    International Nuclear Information System (INIS)

    Radiobiological studies of the biological and chemical effects of X-rays on the marine algae Acetabularia and Batophora and the incorporation of 3H in Acetabularia and Dunaliello were performed. It was shown that the main morphogenetic process of Acetabularia and Batophora are affected by the radiations. Experiments with tritiated water revealed that Acetabularia cells are unable to concentrate 3H. However, a significant amount of this radionuclide is incorporated into the genetic material of the cells. When organically bound 3H is supplied to Acetabularia or Dunaliello, a selective accumulation of some substances is observed. (H.K.)

  11. Nuclear Physics and Radiobiology - Issues for Humans in Space and on Earth

    Science.gov (United States)

    Tripathi, Ram

    2008-10-01

    Nuclear physics is playing a vital role in human biological applications, specifically in planned space missions, in hadron radiotherapy, and in low dose radiobiology. While seemingly disparate, these and other areas share a common need for the understanding of nuclear interactions in biological systems. Radiobiology continues to provide valuable information that will help develop better methods for using radiation in the treatment of disease as well as provide a scientific basis for radiation protection standards. NASA is now focused on the agency's vision for space exploration encompassing a broad range of human and robotic missions including missions to the Moon, Mars and beyond. As a result, there is a focus on long duration space missions. Protection from hazards of space radiation has been identified as one of the five NASA critical areas for human space flight. The cost effective design of spacecraft demands a very stringent requirement on the optimization process. Exposures from the hazards of severe space radiation in deep space and/or long duration missions are very different from that of low earth orbit, and much needs to be done about their effects. However, it is clear that revolutionary technologies will need to be developed. Here on earth, particulate radiation treatment for cancer, such as proton radiotherapy, is playing an increasing important role, while the biological effectiveness remains less well understood than for x-rays and other forms of medical radiation treatments. Advanced imaging, dosimetric, Monte Carlo, and other techniques from nuclear physics are utilized to study the molecular basis of fractionation dependency and other tumor and normal tissue radiation responses, such as radiosensitivity. Moreover, advances developed by biological research efforts, such as the sequencing of the human genome, have opened new horizons for radiobiology. New techniques have made it possible to determine at the cellular / molecular level how living

  12. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 25. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Krause, Mechthild [Universitaetsklinikum Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologie; Cordes, Nils [Universitaetsklinikum Technische Univ. Dresden (Germany). OncoRay - Nationales Zentrum fuer Strahlenforschung in der Radioonkologie; Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany); Petersen, Cordula [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Rodemann, H. Peter [Universitaetsklinikum Tuebingen (Germany). Sektion fuer Strahlenbiologie; Rothkamm, Kai [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Lab. fuer Strahlentherapie und Experimentelle Radioonkologie; Zips, Daniel (ed.) [Tuebingen Univ. (Germany). Universitaetsklinik fuer Radioonkologie

    2016-05-01

    The proceedings of the 25th symposium on experimental radiotherapy and clinical radiobiology include papers on the following issues: radiotherapy individualization based on imaging; pre-clinic imaging and new experimental methods; methods and models, micromilieu and metabolism, combined therapy; secondary tumors following radiotherapy; radiogenic effects in normal tissue; resistance mechanism of tumors and normal tissue; personalized radio-oncology - which biological data are needed; pre-clinic and personalized radio-oncology; biomarkers - pre-clinic and translational; translational examinations for personalized radio-oncology.

  13. Extrapolation ionisation chamber measurements on beta-emitting sources produced for the CEGB collaborative radiobiology programme

    International Nuclear Information System (INIS)

    This report describes the structure and application of an extrapolation ionisation chamber used for measuring dose-rates from plane and point beta-emitting sources. These measurements form the basis of the dosimetry for a collaborative radiobiological study of skin to study both stochastic and non-stochastic effects. A small sample from the wide range of measurements undertaken in the programme has been selected to illustrate the procedures involved. The extrapolation chamber is currently being automated and it is intended that this report should provide a source reference to the basis of the measurements made between 1977-86. (author)

  14. Environmental Research Division annual report: Center for Human Radiobiology, July 1982-June 1983

    International Nuclear Information System (INIS)

    This is the fourteenth Annual Report of the Center for Human Radiobiology. New cases of bone cancer and carcinoma of head sinuses are occurring at a rate of about one per year in patients who acquired radium burdens 50 to 60 years ago. Several papers deal with dosimetry of alpha-emitting radionuclides in man, in animals, or in the environment. The report concludes with an appendix containing data on the exposure of 2312 persons whose radium content has been determined and an appendix listing the classical radium-related malignancies (osteosarcomas and carcinomas of the paranasal sinuses and mastoid)

  15. Dictionary of radiation protection, radiobiology and nuclear medicine. English-German-French-Russian

    International Nuclear Information System (INIS)

    This multilingual dictionary covers the subject fields of radiation protection, radiobiology, and nuclear medicine with about 12,000 terms in each language. All terms are supplemented by one or more abbreviations of 22 special branches to assure the use of the very relevant terms. Special branches listed are for instance decontamination, dosimetry, atomic legislation, radiation detectors, radiography (medical), radiotherapy, safeguards, shielding, tansportation and storage. The terminology used in the International Nuclear Information System (INIS) of the IAEA has been completely taken into account

  16. Development of a compact laser-produced plasma soft X-ray source for radiobiology experiments

    Czech Academy of Sciences Publication Activity Database

    Adjei, D.; Ayele, M.G.; Wachulak, P.; Bartnik, A.; Wegrzynski, L.; Fiedorowicz, H.; Vyšín, Luděk; Wiechec, A.; Lekki, J.; Kwiatek, W.M.; Pina, L.; Davídková, Marie; Juha, Libor

    2015-01-01

    Roč. 364, Dec (2015), s. 27-32. ISSN 0168-583X R&D Projects: GA ČR(CZ) GBP108/12/G108; GA ČR GA13-28721S EU Projects: European Commission(XE) 284464 - LASER LAB-EUROPE Institutional support: RVO:68378271 ; RVO:61389005 Keywords : laser -produced plasma * soft X-rays * radiobiology * gas puff target * water window Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.124, year: 2014

  17. Tcp and NTCP radiobiological models: conventional and hypo fractionated treatments in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Astudillo V, A.; Paredes G, L. [ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico); Resendiz G, G.; Posadas V, A. [Hospital Angeles Lomas, Av. Vialidad de la Barranca s/n, Col. Valle de las Palmas, 52763 Huixquilucan de Degallado, Estado de Mexico (Mexico); Mitsoura, E. [Universidad Autonoma del Estado de Mexico, Facultad de Medicina, Paseo Tollocan, Esq. Jesus Carranza s/n, Col. Moderna de la Cruz, 50180 Toluca, Estado de Mexico (Mexico); Rodriguez L, A.; Flores C, J. M., E-mail: armando.astudillo@inin.gob.mx [Hospital Medica Sur, Puente de Piedra 150, Col. Toriello Guerra, 14050 Tlalpan, Mexico D. F. (Mexico)

    2015-10-15

    The hypo and conventional fractionated schedules performance were compared in terms of the tumor control and the normal tissue complications. From the records of ten patients, treated for adenocarcinoma and without mastectomy, the dose-volume histogram was used. Using radiobiological models the probabilities for tumor control and normal tissue complications were calculated. For both schedules the tumor control was approximately the same. However, the damage in the normal tissue was larger in conventional fractionated schedule. This is important because patients assistance time to their fractions (15 fractions/25 fractions) can be optimized. Thus, the hypo fractionated schedule has suitable characteristics to be implemented. (Author)

  18. Tcp and NTCP radiobiological models: conventional and hypo fractionated treatments in radiotherapy

    International Nuclear Information System (INIS)

    The hypo and conventional fractionated schedules performance were compared in terms of the tumor control and the normal tissue complications. From the records of ten patients, treated for adenocarcinoma and without mastectomy, the dose-volume histogram was used. Using radiobiological models the probabilities for tumor control and normal tissue complications were calculated. For both schedules the tumor control was approximately the same. However, the damage in the normal tissue was larger in conventional fractionated schedule. This is important because patients assistance time to their fractions (15 fractions/25 fractions) can be optimized. Thus, the hypo fractionated schedule has suitable characteristics to be implemented. (Author)

  19. Oxygen as a product of water radiolysis in high-LET tracks. II. Radiobiological implications

    International Nuclear Information System (INIS)

    Consideration is given to the possibility that molecular oxygen generated in the tracks of energetic heavy ions is responsible for the reduction in oxygen enhancement ratio (OER) with increasing linear energy transfer (LET) observed for the loss of reproductive capacity caused by radiation in many cellular organisms. Yields of oxygen relationship of OER to LET for two organisms, Chlamydomonas reinhardii and Shigella flexneri, using a simple diffusion kinetic model for radiobiological action which takes account of the diffusion of oxygen after its formation. The results of these calculations show that the model accounts well for the shape of the OER vs. LET relationship

  20. Research in radiobiology. Annual report of work in progress in the Internal Irradiation Program

    International Nuclear Information System (INIS)

    Survival data on 160 nonirradiated control beagles of the University of Utah's Radiobiology Laboratory were analyzed. The animals died during a period from 1958 into 1979. The average age at death of animals which died during the 1958 to 1965 interval was significantly less than that of those whose deaths occurred in the 1965 to 1979 interval. The best estimate for average age at death for Super-Selected nonirradiated control beagles of the colony is 4864 +- 901 days. The Super-Selected dogs excluded those dying because of epilepsy, lymphosarcoma, lymphoma or accidents, and also excluded all dogs dying before 1966

  1. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 18. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H. Peter; Zips, Daniel (eds.)

    2009-07-15

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity.

  2. The objective qualification of non-international armed conflicts: A Colombian case study

    OpenAIRE

    Sebastian Machado; Guillermo Otálora Lozano

    2012-01-01

    Armed conflict has raged in Colombia since at least the 1960’s, involving governmental forces, rebel groups, and paramilitary forces. The Uribe government (2002-2010) declared that Colombia was not in a ‘state of armed conflict’ but was rather facing a ‘terrorist threat’. This declaration was done in fear of conferring a political status to the armed groups, and most particularly, in fear that a recognition of armed conflict would open the possibility of endowing the Revolutionary Ar...

  3. Development of a multisensory arm for process monitoring in Robot Assisted Polishing

    DEFF Research Database (Denmark)

    Pilny, Lukas; Dalla Costa, Giuseppe; Bissacco, Giuliano;

    Robot Assisted Polishing (RAP) process is capable of achieving surface roughness down to Sa 10 nm on industrial components. In RAP, a robot arm carries a polishing module with controlled contact force utilizing oscillating or rotating tools. In this work a multisensory polishing arm with integrated...... Acoustic Emission (AE), accelerometer and force sensors was developed and the reliability of force measurements for process monitoring in RAP was verified....

  4. Investigations on the quality of treatment plans for carbon ion radiotherapy. Beam delivery systems and radiobiological models

    Energy Technology Data Exchange (ETDEWEB)

    Gillmann, Clarissa

    2014-07-01

    In a worldwide effort in research and development, radiation therapy with carbon ions has evolved to a technologically challenging but clinically very promising treatment option for cancer patients. To further improve patient benefit, optimal use of the physical and biological characteristics of carbon ions as well as of the available technologies should be made. The present thesis investigates the impact of different beam delivery systems and radiobiological models on the quality of treatment plans in carbon ion radiotherapy. The results of the study may provide pointers as to the role and the possible future implementation of the different techniques and radiobiological models in existing and upcoming particle therapy centers.

  5. Design of a radiation facility for very small specimens used in radiobiology studies

    International Nuclear Information System (INIS)

    A design of a radiation facility for very small specimens used in radiobiology is presented. This micro-irradiator has been primarily designed to irradiate partial bodies in zebrafish embryos 3-4 mm in length. A miniature x-ray, 50 kV photon beam, is used as a radiation source. The source is inserted in a cylindrical brass collimator that has a pinhole of 1.0 mm in diameter along the central axis to produce a pencil photon beam. The collimator with the source is attached underneath a computer-controlled movable table which holds the specimens. Using a 45 deg. tilted mirror, a digital camera, connected to the computer, takes pictures of the specimen and the pinhole collimator. From the image provided by the camera, the relative distance from the specimen to the pinhole axis is calculated and coordinates are sent to the movable table to properly position the samples in the beam path. Due to its monitoring system, characteristic of the radiation beam, accuracy and precision of specimen positioning, and automatic image-based specimen recognition, this radiation facility is a suitable tool to irradiate partial bodies in zebrafish embryos, cell cultures or any other small specimen used in radiobiology research

  6. Relationship between tumour oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model

    International Nuclear Information System (INIS)

    Tumour oxygenation and bioenergetic status were measured in the same tumour and these results related to radiobiological hypoxia. A C3H mouse mammary carcinoma grown in the feet of CDF1 mice was used. Bioenergetic status was assessed by 31P MRS using a SISCO 7 Tesla magnet, oxygen measurements were done by a polarographic electrode and the hypoxic fraction was determined from direct analysis of the radiation dose-response data. During all examinations restrained, non-anaesthetized mice were allowed to breathe either 100% oxygen, carbogen, normal air, carbon monoxide (CO) at 75, 220, or 660 ppm or had blood flow occluded by clamping. Results showed a significant correlation between the radiobiological hypoxic fraction and % pO2 ≤ 5 mmHg under the different treatment conditions, whereas no correlation was found between beta nucleosidetriphosphate/inorganic phosphate (β-NTP/Pi) ratio and either the hypoxic fraction or the % of pO2 values ≤ 5 mmHg under the different treatment conditions. In conclusion, oxygen electrode measurements were sensitive to changes in tumour hypoxia whereas the bioenergetic status alone seemed to be a less precise measure of hypoxia in this tumour model. Furthermore, the present study demonstrated that tumour cells in vivo can actually maintain the bioenergetic status during a period of severe hypoxia. (orig.)

  7. Bringing the heavy: carbon ion therapy in the radiobiological and clinical context

    International Nuclear Information System (INIS)

    Radiotherapy for the treatment of cancer is undergoing an evolution, shifting to the use of heavier ion species. For a plethora of malignancies, current radiotherapy using photons or protons yields marginal benefits in local control and survival. One hypothesis is that these malignancies have acquired, or are inherently radioresistant to low LET radiation. In the last decade, carbon ion radiotherapy facilities have slowly been constructed in Europe and Asia, demonstrating favorable results for many of the malignancies that do poorly with conventional radiotherapy. However, from a radiobiological perspective, much of how this modality works in overcoming radioresistance, and extending local control and survival are not yet fully understood. In this review, we will explain from a radiobiological perspective how carbon ion radiotherapy can overcome the classical and recently postulated contributors of radioresistance (α/β ratio, hypoxia, cell proliferation, the tumor microenvironment and metabolism, and cancer stem cells). Furthermore, we will make recommendations on the important factors to consider, such as anatomical location, in the future design and implementation of clinical trials. With the existing data available we believe that the expansion of carbon ion facilities into the United States is warranted

  8. Preparatory study of a ground-based space radiobiology program in Europe

    Science.gov (United States)

    Durante, M.; Kraft, G.; O'Neill, P.; Reitz, G.; Sabatier, L.; Schneider, U.

    Space radiation has long been acknowledged as a potential showstopper for long duration manned interplanetary missions. Our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. In an effort to gain more information on space radiation risk and to develop countermeasures, NASA initiated several years ago a Space Radiation Health Program, which is currently supporting biological experiments performed at the Brookhaven National Laboratory. Accelerator-based radiobiology research in the field of space radiation research is also under way in Russia and Japan. The European Space Agency (ESA) has recently established an ambitious exploration program (AURORA), and within this program it has been decided to include a space radiation research program. Europe has a long tradition in radiobiology research at accelerators, generally focussing on charged-particle cancer therapy. This expertise can be adapted to address the issue of space radiation risk. To support research in this field in Europe, ESA issued a call for tender in 2005 for a preliminary study of investigations on biological effects of space radiation (IBER). This study will provide guidance on future ESA-supported activities in space radiation research by identifying the most appropriate European accelerator facilities to be targeted for cooperation, and by drafting a roadmap for future research activities. The roadmap will include a prioritisation of research topics, and a detailed proposal for experimental campaigns for the following 5 10 years.

  9. The radiobiological principles of boron neutron capture therapy: A critical review

    International Nuclear Information System (INIS)

    The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors. - Highlights: ► Radiobiological properties of different dose components in BNCT are considered. ► Effectiveness of γ-ray dose depends strongly on exposure time due to sublethal damage repair. ► Effectiveness of fast neutron dose depends on neutron energy spectrum. ► γ-ray and fast neutron characteristics vary between beams and thus weighting factors will differ. ► Weighing factors for boron dose depend on the carrier, the tissue and its mode of administration.

  10. The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation

    International Nuclear Information System (INIS)

    Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach. 10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm3. The original 3D conformal plans (50Gy3D) were compared to newly created RapidArc plans of 50GyRA and 60GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared. There was a significant increase in NTCP of the stomach wall when moving from the 50GyRA to the 60GyRA plans (11–17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60GyRA plans. Radiobiological modelling suggests that increasing the prescribed dose to 60Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60Gy

  11. Development of a soft X-ray microprobe for single cell radiobiology

    Institute of Scientific and Technical Information of China (English)

    CHEN Liang; YAN Jingwen; JIANG Shiping; YU Yang

    2009-01-01

    An X-ray microprobe for radiobiological studies was developed which deliver precise doses of radiation to the selected individual cells. The facility used synchrotron radiation as soft X-ray source. A zone plate combining with a pinhole produced a fine probe from bending magnet for single cell irradiating with defined doses. The diameter of microprobe at the target position was about 2 μm by scanning a knife-edge with an AXUV photo diode. The fluxes of soft X-rays at 516.7 eV (2.4 nm) were about 5.4×104 photons/s.100mA measured with the photo diode. The absorbed dose rate for typical yeast cells was about 11.34 Gy/s with the storage current of 100 mA. A preliminary experiment for yeast cells irradiation has shown that the microprobe had a definite biological effect for radiobiological investigations. The soft X-ray microprobe at "water window" region has provided a useful tool for single cell irradiating damage and a capability of individually irradiating a certain numbers of cells each time.

  12. Research in radiobiology: Annual report of work in progress in the internal irradiation program

    International Nuclear Information System (INIS)

    In the early 1950's the Atomic Energy Commission established at the University of Utah a large, long-term study designed to investigate the toxicity of internally deposited radionuclides in beagles. The first animals were injected on December 1, 1952 and thus began an odyssey unusual in modern science both for its duration and continued scientific interest and relevance. The original dogs were injected with 239Pu and 226Ra. Later, studies were initiated with 241Am, 249Cf, 252Cf, 253Es, 224Ra, 228Ra, 90Sr, and 228Th. These studies were unique and have and will continue to contribute valuable scientific information on the behavior and effects of these substances in biological systems. We feel that the data collected from these studies will be useful for many decades to come as we ask more demanding questions relative to radionuclides and environmental, biological and health issues. While this publication will be the last of our series Research in Radiobiology, the lifespan carcinogenesis studies are continuing under a collaborative arrangement with the I.T.R.I. Beginning in 1988, the colony status tables of dogs in the Utah studies and reports of research by the Radiobiology faculty will be included in the annual I.T.R.I. report. Under our new collaborative arrangements with the I.T.R.I. for the conduct of the lifespan carcinogenesis studies, we expect a continued high level of scientific productivity from our faculty

  13. Preliminary results in the application of radiobiological models in the evaluation of radiotherapy plans

    International Nuclear Information System (INIS)

    Notwithstanding the limitations of radiobiological models in the clinical application, its use is becoming more widespread in order to quantitatively assess the bioequivalence of different regimens of irradiation, the effective comparison between different treatment plans by estimating the probability tumor control (TCP) or the probability of normal tissue complication (NTCP), or solve problems, such as the rescheduling of treatments in case of failure. The response to irradiation in the tissues at risk (OARS) depends on factors such as volume irradiated or its organizational structure and behavior can vary for a given dose distribution. Another important aspect is the sensitivity of these models to the variation of parameters (a, a / β, proliferation, clonogenic density, etc.) Measuring the difference between-subjects. Commercial planning systems do not always possible to estimate the biological response of the OARS and CTV. This study presents an assessment of the results of two applications (free ware) and Albireo Target BIOPLAN Cygnus X1 that calculate statistical parameters of the DVH: equivalent uniform dose (EUD), equivalent biological dose (BED), medium dose and other to estimate TCP (Poisson model) and NTCP (Lyman-models-Kutcker Burman and relative seriality) for the calculation of the objective functions: the probability of uncomplicated control (UTCP) based on generalized EUD (f). We studied the response of both systems to the variation of relevant radiobiological parameters and the shape of the DVH. (author)

  14. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness.

    Science.gov (United States)

    Blakely, E A; Kronenberg, A

    1998-11-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue. PMID:9806616

  15. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness

    Science.gov (United States)

    Blakely, E. A.; Kronenberg, A.; Chatterjee, A. (Principal Investigator)

    1998-01-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  16. Radiobiological and PK assays at advance Centre for Training Research and Education in Cancer (ACTREC)

    International Nuclear Information System (INIS)

    Radiobiological, pharmacokinetic and biodistribution studies are of paramount importance for drug development and more so in the development of newer radiation modulators. Radiobiological studies have now graduated from simple cell survival and viability assays to more complex molecular and imaging studies to study radiation modulation both in in-vitro and in-vivo models. Tata Memorial Centre and its research centre (ACTREC) is a premiere cancer centre in India dedicated to cancer research. The Department of Radiation Oncology treats approximately 7000 new patients in a year and is uniquely placed to do both translational radiation and clinical research in the field of drug development. The Clinical Biology Lab of the Department of Radiation Oncology at ACTREC in collaboration with other labs at ACTREC has standardized cell survival assays, DNA damage assays such as Gamma H2AX assay (by flow as well as confocal microscopy), Micronuclei assay and COMET assays using CASP software for quantification. We have also done apoptotic assays. These assays have been conducted for development newer drug formulations (for e.g liposomal radiosensitizers). We also have a strong imaging division having sophisticated microscopes (confocal and single molecule super resolution microscopes) for in-vitro optical imaging and a dedicated preclinical PET/CT/SPECT for in-vivo imaging. The clinical 3T MRI and PET/CT is being used to study the effect of hypoxia in various cancers

  17. The Temporal Structure of Vertical Arm Movements

    Science.gov (United States)

    Gaveau, Jérémie; Papaxanthis, Charalambos

    2011-01-01

    The present study investigates how the CNS deals with the omnipresent force of gravity during arm motor planning. Previous studies have reported direction-dependent kinematic differences in the vertical plane; notably, acceleration duration was greater during a downward than an upward arm movement. Although the analysis of acceleration and deceleration phases has permitted to explore the integration of gravity force, further investigation is necessary to conclude whether feedforward or feedback control processes are at the origin of this incorporation. We considered that a more detailed analysis of the temporal features of vertical arm movements could provide additional information about gravity force integration into the motor planning. Eight subjects performed single joint vertical arm movements (45° rotation around the shoulder joint) in two opposite directions (upwards and downwards) and at three different speeds (slow, natural and fast). We calculated different parameters of hand acceleration profiles: movement duration (MD), duration to peak acceleration (D PA), duration from peak acceleration to peak velocity (D PA-PV), duration from peak velocity to peak deceleration (D PV-PD), duration from peak deceleration to the movement end (D PD-End), acceleration duration (AD), deceleration duration (DD), peak acceleration (PA), peak velocity (PV), and peak deceleration (PD). While movement durations and amplitudes were similar for upward and downward movements, the temporal structure of acceleration profiles differed between the two directions. More specifically, subjects performed upward movements faster than downward movements; these direction-dependent asymmetries appeared early in the movement (i.e., before PA) and lasted until the moment of PD. Additionally, PA and PV were greater for upward than downward movements. Movement speed also changed the temporal structure of acceleration profiles. The effect of speed and direction on the form of acceleration

  18. Radiobiologically optimized couch shift: A new localization paradigm using cone-beam CT for prostate radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yimei, E-mail: yhuang2@hfhs.org; Gardner, Stephen J.; Wen, Ning; Zhao, Bo; Gordon, James; Brown, Stephen; Chetty, Indrin J. [Department of Radiation Oncology, Henry Ford Health System, 2799 W Grand Boulevard, Detroit, Michigan 48202 (United States)

    2015-10-15

    Purpose: To present a novel positioning strategy which optimizes radiation delivery by utilizing radiobiological response knowledge and evaluate its use during prostate external beam radiotherapy. Methods: Five patients with low or intermediate risk prostate cancer were evaluated retrospectively in this IRB-approved study. For each patient, a VMAT plan with one 358° arc was generated on the planning CT (PCT) to deliver 78 Gy in 39 fractions. Five representative pretreatment cone beam CTs (CBCT) were selected for each patient. The CBCT images were registered to PCT by a human observer, which consisted of an initial automated registration with three degrees-of-freedom, followed by manual adjustment for agreement at the prostate/rectal wall interface. To determine the optimal treatment position for each CBCT, a search was performed centering on the observer-matched position (OM-position) utilizing a score function based on radiobiological and dosimetric indices (EUD{sub prostate}, D99{sub prostate}, NTCP{sub rectum}, and NTCP{sub bladder}) for the prostate, rectum, and bladder. We termed the optimal treatment position the radiobiologically optimized couch shift position (ROCS-position). Results: The dosimetric indices, averaged over the five patients’ treatment plans, were (mean ± SD) 79.5 ± 0.3 Gy (EUD{sub prostate}), 78.2 ± 0.4 Gy (D99{sub prostate}), 11.1% ± 2.7% (NTCP{sub rectum}), and 46.9% ± 7.6% (NTCP{sub bladder}). The corresponding values from CBCT at the OM-positions were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.8 ± 0.7 Gy (D99{sub prostate}), 12.1% ± 5.6% (NTCP{sub rectum}), and 51.6% ± 15.2% (NTCP{sub bladder}), respectively. In comparison, from CBCT at the ROCS-positions, the dosimetric indices were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.3 ± 0.6 Gy (D99{sub prostate}), 8.0% ± 3.3% (NTCP{sub rectum}), and 46.9% ± 15.7% (NTCP{sub bladder}). Excessive NTCP{sub rectum} was observed on Patient 5 (19.5% ± 6.6%) corresponding to localization at OM

  19. Arm To Arm Interface Using Embedded C

    Directory of Open Access Journals (Sweden)

    Mohanraj.C

    2013-02-01

    Full Text Available Embedded systems are the most emerging field in these recent years. In this paper a different number of ARM processors (LPC2148 and LPC2378 are interconnected using C for distributed services. N numbers of processors are connected as the network and each processing devices are interlinked with each other, so that the each data that is processed by the devices and it can be used by the other device to activate their entire process. All the processed data’s are communicated to other device through Xbee interface card. LPC2148 and LPC2378 ARM processors are used in this prototype and winXtalk is used as a software terminal window. In this paper, the ultimate benefits of multiple processor interactions related to the embedded applications and design issues of processor interconnection are discussed. The features of multiple processor interaction in inter process communication and executions of embedded multitasking are also discussed. In modern embedded computing platform, embedded processor used in various applications like home automation, industrial control, medical system, access control, etc. In this paper, using embedded processor interactions, the several data communication is established.

  20. PHENIX Muon Arms

    International Nuclear Information System (INIS)

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons (∼10-3). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described

  1. PHENIX Muon Arms

    Energy Technology Data Exchange (ETDEWEB)

    Akikawa, H.; Al-Jamel, A.; Archuleta, J.B.; Archuleta, J.R.; Armendariz, R.; Armijo, V.; Awes, T.C.; Baldisseri, A.; Barker, A.B.; Barnes, P.D.; Bassalleck, B.; Batsouli, S.; Behrendt, J.; Bellaiche, F.G.; Bland, A.W.; Bobrek, M.; Boissevain, J.G.; Borel, H.; Brooks, M.L.; Brown, A.W.; Brown, D.S.; Bruner, N.; Cafferty, M.M.; Carey, T.A.; Chai, J.-S.; Chavez, L.L.; Chollet, S.; Choudhury, R.K.; Chung, M.S.; Cianciolo, V.; Clark, D.J.; Cobigo, Y.; Dabrowski, C.M.; Debraine, A.; DeMoss, J.; Dinesh, B.V.; Drachenberg, J.L.; Drapier, O.; Echave, M.A.; Efremenko, Y.V.; En' yo, H.; Fields, D.E.; Fleuret, F.; Fried, J.; Fujisawa, E.; Funahashi, H.; Gadrat, S.; Gastaldi, F.; Gee, T.F.; Glenn, A.; Gogiberidze, G.; Gonin, M.; Gosset, J.; Goto, Y.; Granier de Cassagnac, R.; Hance, R.H.; Hart, G.W.; Hayashi, N.; Held, S.; Hicks, J.S.; Hill, J.C.; Hoade, R.; Hong, B.; Hoover, A.; Horaguchi, T.; Hunter, C.T.; Hurst, D.E.; Ichihara, T.; Imai, K.; Isenhower, L.D.L. Davis; Isenhower, L.D.L. Donald; Ishihara, M.; Jang, W.Y.; Johnson, J.; Jouan, D.; Kamihara, N.; Kamyshkov, Y.; Kang, J.H.; Kapoor, S.S.; Kim, D.J.; Kim, D.-W.; Kim, G.-B.; Kinnison, W.W.; Klinksiek, S.; Kluberg, L.; Kobayashi, H.; Koehler, D.; Kotchenda, L.; Kuberg, C.H.; Kurita, K.; Kweon, M.J.; Kwon, Y.; Kyle, G.S.; LaBounty, J.J.; Lajoie, J.G.; Lee, D.M.; Lee, S.; Leitch, M.J.; Li, Z.; Liu, M.X.; Liu, X.; Liu, Y.; Lockner, E.; Lopez, J.D.; Mao, Y.; Martinez, X.B.; McCain, M.C.; McGaughey, P.L.; Mioduszewski, S.; Mischke, R.E.; Mohanty, A.K.; Montoya, B.C.; Moss, J.M.; Murata, J.; Murray, M.M.; Nagle, J.L.; Nakada, Y.; Newby, J.; Obenshain, F.; Palounek, A.P.T.; Papavassiliou, V.; Pate, S.F.; Plasil, F.; Pope, K.; Qualls, J.M.; Rao, G.; Read, K.F. E-mail: readkf@ornl.gov; Robinson, S.H.; Roche, G.; Romana, A.; Rosnet, P.; Roth, R.; Saito, N.; Sakuma, T.; Sandhoff, W.F.; Sanfratello, L.; Sato, H.D.; Savino, R.; Sekimoto, M.; Shaw, M.R.; Shibata, T.-A.; Sim, K.S.; Skank, H.D.; Smith, D.E.; Smith, G.D. [and others

    2003-03-01

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons ({approx}10{sup -3}). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described.

  2. Contamination and incorporation due to emission of ionizing radiation from radar equipment of the German Federal Armed Forces. A reply to the report of the staff working group Dr. Sommer, presented 21st June 2001. 2. rev. ed.

    International Nuclear Information System (INIS)

    The document refers to an issue of public debate in Germany, induced by the disclosure of inappropriate occupational safety measures at radar equipment of the German Army and Air Force. In this reply to the official report of investigation, the author gives his own expert opinion, discussing health risks in connection with radar equipment in general, and the specific military radar installations in particular. The author explains his approach to assessing the occupational radiation dose to military personnel and the resulting health risks and effects in that particular case. (orig./CB)

  3. Subatomic forces

    International Nuclear Information System (INIS)

    Inside the atom, particles interact through two forces which are never felt in the everyday world. But they may hold the key to the Universe. These ideas on subatomic forces are discussed with respect to the strong force, the electromagnetic force and the electroweak force. (author)

  4. Electroweak Force

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    The united force that encompasses the electromagnetic force and the weak nuclear force. The unification of these two forces is described by a theory that was devised during the 1960s by Sheldon Glashow, Steven Weinberg and Abdus Salam according to which, at high enough energies, the electromagnetic force and the weak nuclear interaction behave in exactly the same way....

  5. Literature study of the radiobiological parameters of Caesium-137 required for evaluating internal irradiation doses as a function of age

    International Nuclear Information System (INIS)

    This document reassembles information published in scientific literature on radiobiological parameters of Cs-137, necessary for the estimate of the internal irradiation dose of man according to his age (during growth). The data are completed by a commented review of the mathematical models, proposed in order to value the irradiation doses from ingested cesium and the biological parameters. (author)

  6. Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once. (KRM)

  7. Replantation (Finger, Hand, or Arm)

    Science.gov (United States)

    ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ...

  8. Proton Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Tommasino, Francesco [GSI Helmholtzzentrum für Schwerionenforschung, Department of Biophysics, Darmstadt 64291 (Germany); Durante, Marco, E-mail: m.durante@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung, Department of Biophysics, Darmstadt 64291 (Germany); Technische Universität Darmstadt, Institut für Festkörperphysik, Darmstadt 64291 (Germany)

    2015-02-12

    In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming a fixed RBE of 1.1 for the whole radiation field. However, data emerging from recent studies suggest that, for several end points of clinical relevance, the biological response is differentially modulated by protons compared to photons. In parallel, research in the field of medical physics highlighted how variations in RBE that are currently neglected might actually result in deposition of significant doses in healthy organs. This seems to be relevant in particular for normal tissues in the entrance region and for organs at risk close behind the tumor. All these aspects will be considered and discussed in this review, highlighting how a re-discussion of the role of a variable RBE in proton therapy might be well-timed.

  9. Proton Radiobiology

    Directory of Open Access Journals (Sweden)

    Francesco Tommasino

    2015-02-01

    Full Text Available In addition to the physical advantages (Bragg peak, the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE, protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming a fixed RBE of 1.1 for the whole radiation field. However, data emerging from recent studies suggest that, for several end points of clinical relevance, the biological response is differentially modulated by protons compared to photons. In parallel, research in the field of medical physics highlighted how variations in RBE that are currently neglected might actually result in deposition of significant doses in healthy organs. This seems to be relevant in particular for normal tissues in the entrance region and for organs at risk close behind the tumor. All these aspects will be considered and discussed in this review, highlighting how a re-discussion of the role of a variable RBE in proton therapy might be well-timed.

  10. Proton Radiobiology

    OpenAIRE

    Francesco Tommasino; Marco Durante

    2015-01-01

    In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming...

  11. March to Armageddon: The United States and the nuclear arms race, 1939 to the present

    Energy Technology Data Exchange (ETDEWEB)

    Powaski, R.

    1987-01-01

    This history of the events, forces, and factors that have brought the world to the brink of nuclear holocaust probes two basic questions: what factors perpetuate the nuclear arms race and why is it so difficult to end. Starting with the opening days of World War II, this study traces the escalating arms race up to the present and notes that, while nuclear arsenals continue to grow, nuclear arms treaties are on the verge of collapse.

  12. Report on the behalf of the Commission for Foreign Affairs, Defence and Armed Forces on the bill proposition adopted by the National Assembly, related on the strengthening of the protection of civil installations containing nuclear materials. Nr 446

    International Nuclear Information System (INIS)

    In its first part, this report presents the nuclear sector as a sensitive sector under strict surveillance: a sector of critical importance (safety policy with its actors and its multi-level planning, a safety arrangement for the nuclear energy sector), a regulation specific to the nuclear sector, and specialised protection forces. It also addresses the issues of intrusions and over-flights (overview of intrusions, unsuitable penal repression, and new dimension of air safety due to the development of civil uses of drones). The next part comments the content of the bill proposition, and addresses the lack of a suitable penal regime for the protection of nuclear materials and of areas regarding defence. The scope of application of the bill proposition is discussed, as well as the applicable and additional penalties. A list of hearings is provided as well as non adopted amendments and a table proposing a comparison between different versions of the text

  13. Micro-and nanodosimetry for radiobiological planning in radiotherapy and cancer risk assessment in radiation environment

    International Nuclear Information System (INIS)

    Full text: Microdosimetry and nanodosimetry can provide unique information for prediction of radiobiological properties of radiation, which is important in radiation therapy for accurate dose planning and in radiation protection for cancer induction risk assessment. This demand measurements of the pattern of energies deposited by ionizing radiation on cellular scale and DNA levels.Silicon microelectronics technology is offering a unique opportunity for replacing gas proportional counters (TEPC) with miniature detectors for regional microdosimetry. Silicon on Insulator (SOI) technology has been used for the development of arrays of micron size sensitive volumes for modelling energy deposited in biological cells. The challenge in silicon microdosimetry is the development of well defined sensitive volume (SV) and full charge collection deposited by ionizing radiation in the SV. First generation SOI microdosimeters were developed at CMRP and investigated in a wide range of radiation fields for proton and neutron therapies and recently on isotopic neutron sources and heavy ions with energy up to lGeV/jj,m which are typical for deep space radiation environment. Microdosimetric spectra were obtained in a phantom that are well matched to TEPC and Monte Carlo simulations. Evidence that radiations with the same LET exhibit different biological effects demand development of new sensors sensitive to the track structure of ions or the type of particle for prediction of radiobiological effect of radiation using radiobiological models. New monolithic Si AE-E telescope of cellular size for simultaneous regional microdosimetry and particle identification will be presented and results will be discussed. The new design of the SOI microdosimeter is based on 3D micron and submicron size of Si SVs. This approach allows improvement in the accuracy of the Si microdosimetry because of full charge collection and the ability to measure low LET as low as 0.01 keV/jjm, which is similar to TEPC

  14. Modification of radiobiological effects of 171 MeV protons by elements of physical protection

    Science.gov (United States)

    Bulinina, Taisia; Shurshakov, Vyacheslav; Ivanov, Alexander; Molokanov, Alexander

    2016-07-01

    Space radiation includes protons of various energies. Physical protection is effective in the case of low energy protons (50-100 MeV) and becomes insufficient for radiation with a high part of high-energy protons. In the experiment performed on outbred mice, the purpose of the study was to evaluate the radiobiological effect of 171 MeV protons and protons modified by elements of physical protection of the spacecraft, on a complex of indicators of the functional condition of the system hematopoiesis and the central nervous system in 24 hours after irradiation at 20 cGy dose. The spacecraft radiation protection elements used in the experiment were a construction of wet hygiene wipes called a «protective curtain», and a glass plate imitating an ISS window. Mass thickness of the " protective curtain" in terms of water equivalent was ̴ 6,2 g/cm2. Physical shielding along the path of 171 MeV protons increases their linear energy transfer leading to the absorbed dose elevation and strengthening of the radiobiological effect. In the experiment, the two types of shielding together raised the absorbed dose from 20 to 23.2 cGy. Chemically different materials (glass and water in the wipes) were found to exert unequal modifying effects on physical and biological parameters of the proton-irradiated mice. There was a distinct dose-dependent reduction of bone marrow cellularity within the dose range from 20 cGy to 23.2 cGy in 24 hours after exposure. No modifying effect of the radiation protection elements on spontaneous motor activity was discovered when compared with entrance protons. The group of animals protected by the glass plate exhibited normal orientative-trying reactions and weakened grip with the forelimbs. The effects observed in the experiment indicate the necessity to carry out comprehensive radiobiological researches (physical, biological and mathematical) in assessing the effects of physical protection, that are actual for ensuring radiation safety of crews in

  15. Assessment of radiobiological metrics applied to patient-specific QA process of VMAT prostate treatments.

    Science.gov (United States)

    Clemente-Gutiérrez, Francisco; Pérez-Vara, Consuelo; Clavo-Herranz, María H; López-Carrizosa, Concepción; Pérez-Regadera, José; Ibáñez-Villoslada, Carmen

    2016-01-01

    VMAT is a powerful technique to deliver hypofractionated prostate treatments. The lack of correlations between usual 2D pretreatment QA results and the clini-cal impact of possible mistakes has allowed the development of 3D verification systems. Dose determination on patient anatomy has provided clinical predictive capability to patient-specific QA process. Dose-volume metrics, as evaluation crite-ria, should be replaced or complemented by radiobiological indices. These metrics can be incorporated into individualized QA extracting the information for response parameters (gEUD, TCP, NTCP) from DVHs. The aim of this study is to assess the role of two 3D verification systems dealing with radiobiological metrics applied to a prostate VMAT QA program. Radiobiological calculations were performed for AAPM TG-166 test cases. Maximum differences were 9.3% for gEUD, -1.3% for TCP, and 5.3% for NTCP calculations. Gamma tests and DVH-based comparisons were carried out for both systems in order to assess their performance in 3D dose determination for prostate treatments (high-, intermediate-, and low-risk, as well as prostate bed patients). Mean gamma passing rates for all structures were bet-ter than 92.0% and 99.1% for both 2%/2 mm and 3%/3 mm criteria. Maximum discrepancies were (2.4% ± 0.8%) and (6.2% ± 1.3%) for targets and normal tis-sues, respectively. Values for gEUD, TCP, and NTCP were extracted from TPS and compared to the results obtained with the two systems. Three models were used for TCP calculations (Poisson, sigmoidal, and Niemierko) and two models for NTCP determinations (LKB and Niemierko). The maximum mean difference for gEUD calculations was (4.7% ± 1.3%); for TCP, the maximum discrepancy was (-2.4% ± 1.1%); and NTCP comparisons led to a maximum deviation of (1.5% ± 0.5%). The potential usefulness of biological metrics in patient-specific QA has been explored. Both systems have been successfully assessed as potential tools for evaluating the clinical

  16. Hadron Radiobiology : Investigation of the Inhibition of ten days Growth of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2 Hadron Radiobiology : Investigation of the Inhibition of ten days'Grown of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2

    CERN Multimedia

    2002-01-01

    Hadron Radiobiology : Investigation of the Inhibition of ten days Growth of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2 Hadron Radiobiology : Investigation of the Inhibition of ten days'Grown of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2

  17. Optimized electrostatic inchworm motors using a flexible driving arm

    International Nuclear Information System (INIS)

    A new motor architecture that uses in-plane electrostatic gap-closing actuators along with a flexible driving arm mechanism to improve motor force density is introduced, optimized, manufactured, and tested. This motor operates similarly to other inchworm-based microactuators by accumulating small displacements from the actuators into much larger displacements in the motor. Using an analytical model of the inchworm motor based on the static force equilibrium condition, optimizations of a full motor design were performed to maximize motor force density. In addition, force losses from supporting flexures were included to calculate the theoretical motor efficiency for different motor designs. This force density optimization analysis of the gap-closing actuators and supporting motor structures provided the basis for designing and manufacturing inchworm motors with flexible driving arms and gap-closing actuators. The motor required only a single-mask fabrication and demonstrated robust performance, a maximum speed of 4.8 mm s−1, and a maximum force on the shuttle of 1.88 mN at 110 V which corresponds to area force density of 1.38 mN mm−2. In addition, instead of estimating motor force based on drawn or measured dimensions which often overestimates force, the demonstrated maximum motor force was measured using calibrated springs. The efficiency of the manufactured motor was measured at 8.75% using capacitance measurements and useful work output. (paper)

  18. Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiation

    Science.gov (United States)

    Nelson, G. A.; Schubert, W. W.; Marshall, T. M.

    1992-01-01

    The biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represent a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space.

  19. Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiation

    International Nuclear Information System (INIS)

    The biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represents a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space. (author)

  20. Radiobiologic risk estimation from dental radiology. Part I. Absorbed doses to critical organs

    International Nuclear Information System (INIS)

    The aim of the present study was to generate one consistent set of data for evaluating and comparing radiobiologic risks from different dental radiographic techniques. To accomplish this goal, absorbed doses were measured in fourteen anatomic sites from (1) five different panoramic machines with the use of rare-earth screens, (2) a twenty-film complete-mouth survey with E-speed film, long round cone, (3) a twenty-film complete-mouth survey with E-speed film, long rectangular cone, (4) a four-film interproximal survey with E-speed film, long round cone, and (5) a four-film interproximal survey with E-speed film, long rectangular cone. The dose to the thyroid gland, the active bone marrow, the brain, and the salivary glands was evaluated by means of exposure of a tissue-equivalent phantom, fitted with lithium fluoride thermoluminescent dosimeters (TLDs) at the relevant locations

  1. Radiobiologic risk estimation from dental radiology. Part II. Cancer incidence and fatality

    International Nuclear Information System (INIS)

    With the use of the measured absorbed doses from part I of this article, the specific radiobiologic risk to the patient from (1) five different panoramic machines with rare-earth screens, (2) a 20-film complete-mouth survey with E-speed film, long round cone, (3) a 20-film complete-mouth survey with E-speed film, long rectangular cone, (4) a 4-film interproximal survey with E-speed film, long round cone, and (5) a 4-film interproximal survey with E-speed film, long rectangular cone, was calculated. The estimated risks are expressed in two ways: the probability of radiation-induced cancer in specific organs per million examinations and the probability of expression of a fatal cancer per million examinations. The highest risks calculated were from the complete-mouth survey with the use of round collimation. The lowest risks calculated were from panoramic radiography and four interproximal radiographs with rectangular collimation

  2. Treatment plan comparison between helical tomotherapy and MLC-based IMRT using radiobiological measures

    Science.gov (United States)

    Mavroidis, Panayiotis; Costa Ferreira, Brigida; Shi, Chengyu; Lind, Bengt K.; Papanikolaou, Nikos

    2007-07-01

    The rapid implementation of advanced treatment planning and delivery technologies for radiation therapy has brought new challenges in evaluating the most effective treatment modality. Intensity-modulated radiotherapy (IMRT) using multi-leaf collimators (MLC) and helical tomotherapy (HT) are becoming popular modes of treatment delivery and their application and effectiveness continues to be investigated. Presently, there are several treatment planning systems (TPS) that can generate and optimize IMRT plans based on user-defined objective functions for the internal target volume (ITV) and organs at risk (OAR). However, the radiobiological parameters of the different tumours and normal tissues are typically not taken into account during dose prescription and optimization of a treatment plan or during plan evaluation. The suitability of a treatment plan is typically decided based on dosimetric criteria such as dose-volume histograms (DVH), maximum, minimum, mean and standard deviation of the dose distribution. For a more comprehensive treatment plan evaluation, the biologically effective uniform dose ({\\bar{\\bar{D}}}) is applied together with the complication-free tumour control probability (P+). Its utilization is demonstrated using three clinical cases that were planned with two different forms of IMRT. In this study, three different cancer types at different anatomical sites were investigated: head and neck, lung and prostate cancers. For each cancer type, a linac MLC-based step-and-shoot IMRT plan and a HT plan were developed. The MLC-based IMRT treatment plans were developed on the Philips treatment-planning platform, using the Pinnacle 7.6 software release. For the tomotherapy HiArt plans, the dedicated tomotherapy treatment planning station was used, running version 2.1.2. By using {\\bar{\\bar{D}}} as the common prescription point of the treatment plans and plotting the tissue response probabilities versus {\\bar{\\bar{D}}} for a range of prescription doses

  3. A method for radiobiological investigations in radiation fields with different LET and high dose rates

    International Nuclear Information System (INIS)

    For investigations: 1. Performed in the field of radiobiology with different LET-radiation and a relatively high background dose rate of one component (e.g. investigations with fast and intermediate reactor neutrons) 2. Concerning radiation risk studies within a wide range 3. Of irradiations, covering a long time period (up to 100 days) a test system is necessary which on the one hand makes it possible to analyze the influence of different LET radiation and secondly shows a relative radiation resistant behaviour and allows a simple cell cycle regulation. A survey is given upon the installed device of a simple cell observation method, the biological test system used and the analysis of effects caused by dose, repair and LET. It is possible to analyze the behaviour of the nonsurvival cells and to demonstrate different reactions of the test parameters to the radiation of different LET. (author)

  4. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    Science.gov (United States)

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  5. Hypo-fractionated treatment in radiotherapy: radio-biological models Tcp and NTCP

    International Nuclear Information System (INIS)

    At the present time the breast cancer in Mexico has the first place of incidence of the malignant neoplasia s in the women, and represents 11.34% of all the cancer cases. On the other hand, the treatments for cancer by means of ionizing radiations have been dominated under the approaches of the medical radio-oncologists which have been based on test and error by many years. The radio-biological models, as the Tcp, NTCP and dosimetric variables, for their clinical application in the conventional radiotherapy with hypo-fractionation have as purpose predicting personalized treatment plans that they present most probability of tumor control and minor probability of late reactions, becoming this way support tools in the decisions taking for the patient treatments planning of Medical Physicists and Radio-oncologists. (Author)

  6. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy

    Science.gov (United States)

    Champion, C.; Quinto, M. A.; Monti, J. M.; Galassi, M. E.; Weck, P. F.; Fojón, O. A.; Hanssen, J.; Rivarola, R. D.

    2015-10-01

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence—expressed in terms of total cross sections—as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.

  7. Linear versus non-linear: a perspective from health physics and radiobiology

    International Nuclear Information System (INIS)

    There is a vigorous debate about whether or not there may be a 'threshold' for radiation-induced adverse health effects. A linear-no threshold (LNT) model allows radiation protection practitioners to manage putative risk consistently, because different types of exposure, exposures at different times, and exposures to different organs may be summed. If we are to argue to regulators and the public that low doses are less dangerous than we presently assume, it is incumbent on us to prove this. The question is, therefore, whether any consonant body of evidence exists that the risk of low doses has been over-estimated. From the perspectives of both health physics and radiobiology, we conclude that the evidence for linearity at high doses (and arguably of fairly small total doses if delivered at high dose rate) is strong. For low doses (or in fact, even for fairly high doses) delivered at low dose rate, the evidence is much less compelling. Since statistical limitations at low doses are almost always going to prevent a definitive answer, one way or the other, from human data, we need a way out of this epistemological dilemma of 'LNT or not LNT, that is the question'. To our minds, the path forward is to exploit (1) radiobiological studies which address directly the question of what the dose and dose rate effectiveness factor is in actual human bodies exposed to low-level radiation, in concert with (2) epidemiological studies of human populations exposed to fairly high doses (to obtain statistical power) but where exposure was protracted over some years. (author)

  8. Radioembolisation with 90Y-microspheres: dosimetric and radiobiological investigation for multi-cycle treatment

    International Nuclear Information System (INIS)

    Radioembolisation with 90Y-microspheres is a new locoregional treatment of hepatic lesions, usually applied as single cycle. Multi-cycle treatments might be considered as a strategy to improve the risk-benefit balance. With the aim to derive suitable information for patient tailored therapy, available patients' dosimetric data were reviewed according to the linear-quadratic model and converted into biological effective dose (BED) values. Single vs. multi-cycle approaches were compared through radiobiological perspective. Twenty patients with metastatic lesions underwent radioembolisation. The 90Y-administered activity (AA) was established in order to respect a precautionary limit dose (40 Gy) for the non-tumoral liver (NTL). BED was calculated setting α/β 2.5 Gy (NTL), 10 Gy (tumours); T1/2,eff = T1/2,phys = 64.2 h; T1/2,rep = 2.5 h (NTL), 1.5 h (tumours). The BED to NTL was considered as a constraint for multi-cycle approach. The AA for two cycles and the percent variations of AA, tumour dose, BED were estimated. In one-cycle, for a prescribed BED to NTL of 64 Gy (NTL dose = 40 Gy), AA was 1.7 (0.9-3.2) GBq, tumour dose was 130 (65-235) Gy, and tumour BED was 170 (75-360) Gy. Considering two cycles, ∝15% increase was found for AA and dose to NTL, with unvaried BED for NTL. Tumour dose increase was 20 (10-35) Gy; tumour BED increase was 10 (3-11) Gy. In different protocols allowing 80 Gy to NTL, the BED sparing estimated was ∝50 Gy (two cycles) and 65 Gy (three cycles). From a radiobiological perspective, multi-cycle treatments would allow administering higher activities with increased tumour irradiation and preserved radiation effects on NTL. Trials comparing single vs. multiple cycles are suggested. (orig.)

  9. Radiobiological research for improving cancer therapy in India: rationale, problems and prospects

    International Nuclear Information System (INIS)

    Cancer is emerging as a very important health hazard in India. According to recent studies by the Indian Council of Medical Research, about 2.25 million patients are presently suffering from different types of cancer in India. Approximately one million new cases are diagnosed, and nearly 0.3 million deaths occur every year on account of this disease. About 2/3rd of the cancers are at an advanced stage at the time of diagnosis. However, the allocation of funds for healthcare in India to support the research efforts for developing more potent radio-chemotherapy protocols for cancer treatment is too little. Studies by the W.H.O. have estimated that less developed countries including India use less than 5% of world resources destined for cancer control. It follows from the above discussions that it is imperative to further encourage and diversify the radiobiological research in India. This can be achieved by creating radiobiological research facilities, mainly in all the cancer centers and post graduate medical institutions, and further expanding the upcoming laboratories in the universities such as Bikaner. Collaborative research programs between laboratories at different centers could facilitate systematic evaluation of various pharmacological agents and neutraceuticals for potential application for treatment of different cancers. Our studies on combination of radiation with temozolomide and certain adjuvants with selective effects on brain tumour cells will be very briefly discussed in this presentation. Finally the possible administrative set up and multi dimensional collaborations for cost effective utilization of existing resources to further augment radiation biology research will also be discussed

  10. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.

    Science.gov (United States)

    Lee, J; Siemann, D W; Koch, C J; Lord, E M

    1996-07-29

    While the potential importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been appreciated, methods for accurately quantifying the number of radiation-resistant hypoxic cells within tumors have been lacking. We have used the pentafluorinated derivative [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acet amide] of etanidazole (EF5), which binds selectively to hypoxic cells. The adducts formed between EF5 and cellular proteins in the hypoxic cells were detected using the specific monoclonal antibody (MAb), ELK3-51 conjugated to the flurochrome Cy3, and the number of hypoxic cells was quantified by flow cytometry. To verify the validity of this technique for the detection of hypoxic cells, mice bearing KHT sarcomas were treated with various agents to alter tumor oxygenation and hence vary the fraction of radiobiologically hypoxic tumor cells. The percentage of EF5 binding cells was then compared directly with the clonogenic survival of the tumor cells following radiation treatment under the various pretreatment conditions. The results showed that allowing the mice to breathe carbogen (5% CO2/95% O2) prior to irradiation reduced clonogenic cell survival approx. 6-fold and led to an absence of cells binding high levels of EF5. In contrast, pretreating the tumor-bearing animals with either hydralazine, which decreased tumor blood flow, or phenylhydrazine hydrochloride, which made the mice anemic, increased tumor cell survival following irradiation 2- to 4-fold, indicative of an increase in the fraction of hypoxic tumor cells. EF5 measurements made under identical conditions illustrated a shift in the cells in the tumor to high EF5 binding. Our results demonstrate that flow cytometric measurement by fluorescent MAb binding to EF5 adducts may relate directly to radiobiological hypoxia in KHT tumors measured by conventional methods. PMID:8707411

  11. Forced displacement in Colombia: Magnitude and causes

    OpenAIRE

    Ana María Ibáñez

    2009-01-01

    The article describes the magnitude, geographical extent, and causes of forced populationdisplacements in Colombia. Forced migration in Colombia is a war strategy adopted by armed groups to strengthen territorial strongholds, weaken civilian support to the enemy, seize valuable lands, and produce and transport illegal drugs with ease. Forced displacement in Colombia today affects 3.5 million people. Equivalent to 7.8 percent of Colombia’s population, and second worldwide only to Sudan, this s...

  12. From Territorial Defence to Expeditionary Forces

    DEFF Research Database (Denmark)

    Nyemann, Dorthe; Staun, Jørgen Meedom

    2016-01-01

    After the Cold War the Danish Armed Forces moved away from its traditional role of territorial defense of Danish soil and towards a role as a globally deployable expeditionary force, imbedded with UK and/or US forces. This shift in national strategy amplified the requirements of the young officers......’ ability to think and act strategically in international missions. This article discusses to what extent this has been reflected in the education of the young officers....

  13. Robot arm apparatus

    Science.gov (United States)

    Nachbar, Henry D.

    1992-01-01

    A robot arm apparatus is provided for inspecting and/or maintaining an interior of a steam generator which has an outside wall and a port for accessing the interior of the steam generator. The robot arm apparatus includes a flexible movable conduit for conveying inspection and/or maintenance apparatus from outside the steam generator to the interior of the steam generator. The flexible conduit has a terminal working end which is translated into and around the interior of the steam generator. Three motors located outside the steam generator are employed for moving the terminal working end inside the steam generator in "x", "y", and "z" directions, respectively. Commonly conducted inspection and maintenance operations include visual inspection for damaged areas, water jet lancing for cleaning sludge deposits, core boring for obtaining sludge deposits, and scrubbing of internal parts.

  14. Microelectromechanical safe arm device

    Energy Technology Data Exchange (ETDEWEB)

    Roesler, Alexander W. (Tijeras, NM)

    2012-06-05

    Microelectromechanical (MEM) apparatus and methods for operating, for preventing unintentional detonation of energetic components comprising pyrotechnic and explosive materials, such as air bag deployment systems, munitions and pyrotechnics. The MEM apparatus comprises an interrupting member that can be moved to block (interrupt) or complete (uninterrupt) an explosive train that is part of an energetic component. One or more latching members are provided that engage and prevent the movement of the interrupting member, until the one or more latching members are disengaged from the interrupting member. The MEM apparatus can be utilized as a safe and arm device (SAD) and electronic safe and arm device (ESAD) in preventing unintentional detonations. Methods for operating the MEM apparatus include independently applying drive signals to the actuators coupled to the latching members, and an actuator coupled to the interrupting member.

  15. Kiikuv maja / Anu Arm

    Index Scriptorium Estoniae

    Arm, Anu

    2006-01-01

    Eesti Kunstiakadeemia esimese kursuse arhitektuuriüliõpilaste II semestri töö. Juhendaja arhitekt Andres Alver, ehitamise Pedaspeale organiseeris suvepraktika juhendaja arhitekt Jaan Tiidemann. Autor Anu Arm, kaasa töötasid ja valmis ehitasid: Ott Alver, Maarja Elm, Mari Hunt, Alvin Järving, Marten Kaevats, Riho Kerge, Reedik Poopuu, Anu Põime, Helen Rebane, Kaisa Saarva, Martin Tago, Reet Volt. Valmis: 19. VIII 2006

  16. Is there a role for comparative radiobiology in the development of a policy to protect the environment from the effects of ionizing radiation? Comparative radiobiology and radiation protection

    International Nuclear Information System (INIS)

    The last few years has seen what people are now referring to as a 'shifting paradigm' in our way of thinking about radiation effects on biological systems. The concept of the central role of DNA damage due to double strand breaks induced by a radiation 'hit' has been itself hit by many studies showing persistent effects in the distant progeny of radiation exposed cells. This phenomenon is known as radiation induced genomic instability. More recently evidence has been accumulating that not even the parent cell need be exposed to radiation (the bystander effect), and that the bystander cells can demonstrate genomic instability and effects at low doses which are inconsistent with a mechanism based on DNA hits as important targets at low doses. The new paradigm suggests that cellular stress responses or damage signalling through a range of signal transduction pathways are involved. Cell-cell contact or secretion of damage signalling molecules can induce responses in undamaged and unirradiated cells. Are these new effects relevant to risk assessment, or does it matter how radiation affects cells if we have good epidemiological evidence on which to base our risk estimates? If DNA based dose responses are not so important at environmentally relevant doses, then it is not logical to base our environmental protection system on consideration of radiation dose as if this is in some way unique and not affected by the presence of other environmental stressors. The aim of this paper is to review the new concepts and to consider reasons why they might alter our methods of risk estimation. In particular the paper considers the impact of the new concepts on environmental protection and discusses the need for research in the field of comparative radiobiology if we are to develop policies which can adequately protect biodiversity. (author)

  17. Wind power and defense interests on Gotland. Presentation of a joint project between the County Administrative Board, Region Gotland and the Swedish Armed Forces in 2011; Vindkraft och foersvarsintressen paa Gotland. Redovisning av ett samverkansprojekt mellan Laensstyrelsen, Region Gotland och Foersvarsmakten 2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The island of Gotland has a large potential for wind power production. An existing weather radar system, however, causes extensive restrictions for further development of wind power on Gotland. In a joint project during 2011 the County Administration Board of Gotland, the Municipality of Gotland and the Swedish Armed Forces have explored ways to overcome the existing conflicts. The project has been sponsored by the Swedish Energy Agency. Through the collaboration, the participants have gained a better understanding of various aspects of the conflicting interests. Studies have been carried out with the prospect to modelling alternative solutions to reduce the conflicts. The study regarding the radar system has been carried out by the Swedish Meteorological and Hydrological Inst.. This report present some practical solutions to avoid conflict in most of areas which are planned for wind power by the municipality. It is suggested that a complimentary radar can be built. A number of alternative localizations for the complimentary radar have been suggested and the potential effects for wind power production estimated. Costs for the suggested solutions have been calculated.

  18. Armed Conflict: A Model for Understanding and Intervention

    Science.gov (United States)

    Death Studies, 2013

    2013-01-01

    Acts of deadly violence give rise to powerful emotions and trigger pre-programmed responses that often cause affected persons, including leaders, media, armed forces, and the general public, to act in ways that aggravate the situation and feed into cycles of violence. In this article, a model of the cycle of violence is presented that facilitates…

  19. Limitation and reduction of conventional arms

    International Nuclear Information System (INIS)

    We are living at a time when war between East and West---not only nuclear but also conventional war--- is totally senseless. It cannot solve any problem---political, economic, or other. From the military point of view, war between East and West is madness. Calculations show that after 20 days of conventional warfare Europe could become another Hiroshima. Therefore we must work out forms of long-term cooperation. Before it is too late, we must radically reduce our military potentials and rethink our military doctrines. The reduction by 500,000 men is for the USSR no simple solution. But that step may become a model for further actions by East and West. The West's proposal that armed forces should be reduced to the level of 95 percent of NATO's armed forces is not a solution. Both sides---the Warsaw Treaty Organization and NATO---must be deprived of the capacity to launch a sudden attack; they must be deprived of their attack potential. The USSR initiative shows the true way toward that goal. What is happening in connection with our decision is not always correctly interpreted in the West, and so I should like to draw attention to some distinctive features of the Soviet armed forces reductions and, first of all, their scale (equivalent to the Bundeswehr of the Federal Republic of Germany). With respect to Europe, Soviet troops are to be reduced in the German Democratic Republic, Czechoslovakia, Hungary, Poland, and the European part of the Soviet Union---a total of 240,000 men, 10,000 tanks, 9,500 artillery systems, and 800 combat aircraft

  20. Estimation of the radiobiological and kinetic factors of radiosensitivity and radiocurability of metastases of squamous cell carcinoma of the larynx to neck lymph nodes

    International Nuclear Information System (INIS)

    The usefulness of theoretical model of tumour growth and experimental methods of kinetic and radiobiological factors for analysis of clinical data to improve the effectiveness of dose fractionation are checked. 176 refs., 27 figs., 19 tabs. (author)

  1. Supporting the President's Arms Control and Nonproliferation Agenda: Transparency and Verification for Nuclear Arms Reductions

    International Nuclear Information System (INIS)

    The President's arms control and nonproliferation agenda is still evolving and the details of initiatives supporting it remain undefined. This means that DOE, NNSA, NA-20, NA-24 and the national laboratories can help define the agenda, and the policies and the initiatives to support it. This will require effective internal and interagency coordination. The arms control and nonproliferation agenda is broad and includes the path-breaking goal of creating conditions for the elimination of nuclear weapons. Responsibility for various elements of the agenda will be widely scattered across the interagency. Therefore an interagency mapping exercise should be performed to identify the key points of engagement within NNSA and other agencies for creating effective policy coordination mechanisms. These can include informal networks, working groups, coordinating committees, interagency task forces, etc. It will be important for NA-20 and NA-24 to get a seat at the table and a functional role in many of these coordinating bodies. The arms control and nonproliferation agenda comprises both mature and developing policy initiatives. The more mature elements such as CTBT ratification and a follow-on strategic nuclear arms treaty with Russia have defined milestones. However, recent press reports indicate that even the START follow-on strategic arms pact that is planned to be complete by the end of 2009 may take significantly longer and be more expansive in scope. The Russians called for proposals to count non-deployed as well as deployed warheads. Other elements of the agenda such as FMCT, future bilateral nuclear arms reductions following a START follow-on treaty, nuclear posture changes, preparations for an international nuclear security summit, strengthened international safeguards and multilateral verification are in much earlier stages of development. For this reason any survey of arms control capabilities within the USG should be structured to address potential needs across the

  2. Neural Network L-two-gain Robust Control for Flexible Arm Space Robot Based on Virtual Control Force Conception%柔性臂空间机器人基于虚拟力概念的神经网络L2增益鲁棒控制

    Institute of Scientific and Technical Information of China (English)

    梁捷; 陈力

    2012-01-01

    探讨本体位置不控、姿态受控的漂浮基柔性臂空间机器人系统在惯性参数不确定情况下的动力学建模与控制问题.根据系统位置几何关系、动量守恒关系和第二类拉格朗日方程,由假设模态法,建立漂浮基柔性臂空间机器人的系统动力学模型.利用该模型,针对系统惯性参数不确定情况,提出具有L2扰动抑制的刚性运动神经网络L2增益鲁棒控制策略,以使柔性臂空间机器人的本体姿态到达期望位置的同时,机械臂各关节铰能够协调地跟踪关节空间的期望轨迹.为了主动抑制柔性振动,运用虚拟力的概念,构造同时反映柔性模态和刚性运动轨迹的混合期望轨迹,通过改造原有的控制方案,提出基于虚拟力概念的神经网络L2增益鲁棒控制策略.提出控制器的优点在于,既不要求系统动力学方程关于惯性参数呈线性函数关系,也无须预知系统精确的动力学模型;由于运用了虚拟力的概念,从而仅通过设计一个控制输入便可同时保证刚性轨迹跟踪并对柔性振动进行主动抑制,更适应于空间机器人系统的实际应用.理论分析及仿真算例均表明了控制方法的可行性.%Concerned dynamic modeling and control problems are discussed for free-floating flexible arm space robot with uncertain parameters and an uncontrolled base. According to the geometric relationship and law of conversation of momentum, the Lagrange equation of the second kind is utilized to model the dynamic function of the flexible arm space robot incorporating the assumed modes method. By using this model, a neural network L-two-gain robust control scheme with i-two-gain disturbance attenuation is proposed to dominate the base attitude and the joint angle of manipulator to track desired trajectories synchronously in joint space on condition that system parameters are unknown. In order to damp out vibration, conception of virtual force is used to design

  3. Optimization in brachytherapy with the implementation of Radiobiology; Optimizacion en Braquiterapia con la implementacion de la Radiobiologia

    Energy Technology Data Exchange (ETDEWEB)

    Duran, M.P.; Bourel, V.J.; Rodriguez, I.; Torre, M. de la; Caneva, S. [Braqui S.R.L. Viamonte 1861, Buenos Aires (Argentina)

    1998-12-31

    In the brachytherapy planning treatments with High dose rates (HDR), the optimization algorithms used are based in dosimetric considerations and/or geometric ones, ignoring the radiobiological response of the tissue treated. In this work we wish to show the implementation of radiobiological concepts in the optimization. Assuming that the subtiles differences that result in the dose distribution among the different optimization models which are not visible in an isodose plane, it is studied how is classically make it , the quality implant through natural histograms about dose volumes and the resulting parameters. Also is studied the necrosis probability which may be caused by the choice of some optimization model, allowing with this the choice of the best implant. (Author)

  4. Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints

    International Nuclear Information System (INIS)

    Today there is general awareness of the potential damage to the heart in left-sided (more than in right-sided) breast cancer radiotherapy (RT). Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Individual and pharmacological risk factors are also examined with respect to radiation damage. The biological mechanisms of harm are only partially understood, such as the radiobiology of heart damage due to the presence of various radiosensitive structures and their topographic heterogeneity. Furthermore, individual variability may expose patients to higher or lower risks of late cardiac damage or death. Damage mechanisms and radiobiological characteristics in heart irradiation are presented in relation to dosimetric and biological parameters.

  5. Estimating propulsive forces--sink or swim?

    Science.gov (United States)

    Lauder, M A; Dabnichki, P

    2005-10-01

    The purpose of this study was to investigate the validity of hydrodynamic force estimation in swimming as calculated by the quasi-static approach. To achieve this a full-scale mechanical arm was developed, built and tested. The mechanical arm, covered with a prosthetic shell and driven at the shoulder was used to simulate a single plane underwater rotation at four elbow configurations. A computer program controlled the shoulder movement to achieve a replicable angular velocity profile for each arm movement. A strain gauge system was used to directly measure the generated arm torque. Repeated trials were conducted at fixed elbow angles of 110 degrees, 135 degrees, 160 degrees and 180 degrees. All trials were filmed using a three-dimensional underwater set-up. Each trial was digitised at 25 Hz and the hydrodynamic drag force profile of the hand calculated using the quasi-static procedure. From these data, the estimated shoulder torque was calculated and compared to the direct measurement of shoulder torque from the mechanical arm. The results showed that the arm produced a repeatable movement through the water. The shoulder torque profiles using the direct measure (the arm) and the indirect measures (quasi-static approach) differed considerably. The quasi-static approach appears not to accurately reflect the hydrodynamic force profile generated by the arm movement in swimming. Furthermore, it seems that the swimmer's hand contribution is overstated in up to date studies. It is essential that the propulsive mechanisms in swimming be further investigated if factors underpinning an optimal technique are to be established. PMID:16045915

  6. Disarmament and arms control

    International Nuclear Information System (INIS)

    This report discusses how far science and technology can provide methods of making arms control and disarmament agreements more controlable in an objective way. Two case studies have been considered, the test ban treaty and the verification of the number of strategic nuclear weapons. These lead to the conclusion that both science and politics are closely interwoven and that within what appear to be scientific arguments, political positions are being defended. Consequently scientists and technologists and the contexts in which they work, play a prominent role. (C.F.)

  7. Radiobiological effects in organisms of plants and animals exposed to ionizing irradiation in the Chernobyl NPP zone

    International Nuclear Information System (INIS)

    Influence of ionizing radiation on forest ecosystems most clearly revealed itself near the Chernobyl NPP (ChNPP), were magnitudes of absorbed doses reached 'lethal' values, as applied to conifers. Main contribution to absorbed dose was due to beta-radiation of short-living radionuclides. To largest extent the radiobiological effects appeared at injured plantations of pines and firs. Nevertheless, during the first year maximum absorbed doses influenced also on leaf-bearing trees (birch, alder, asp) which then rehabilitated themselves completely

  8. Relationships Between Rectal Wall Dose-Volume Constraints and Radiobiologic Indices of Toxicity for Patients With Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: The purpose of this article was to investigate how exceeding specified rectal wall dose-volume constraints impacts on the risk of late rectal bleeding by using radiobiologic calculations. Methods and Materials: Dose-volume histograms (DVH) of the rectal wall of 250 patients with prostate cancer were analyzed. All patients were treated by three-dimensional conformal radiation therapy, receiving mean target doses of 80 Gy. To study the main features of the patient population, the average and the standard deviation of the distribution of DVHs were generated. The mean dose , generalized equivalent uniform dose formulation (gEUD), modified equivalent uniform dose formulation (mEUD)0, and normal tissue complication probability (NTCP) distributions were also produced. The DVHs set was then binned into eight classes on the basis of the exceeding or the fulfilling of three dose-volume constraints: V40 = 60%, V50 = 50%, and V70 = 25%. Comparisons were made between them by , gEUD, mEUD0, and NTCP. Results: The radiobiologic calculations suggest that late rectal toxicity is mostly influenced by V70. The gEUD and mEUD0 are risk factors of toxicity always concordant with NTCP, inside each DVH class. The mean dose, although a reliable index, may be misleading in critical situations. Conclusions: Both in three-dimensional conformal radiation therapy and particularly in intensity-modulated radiation therapy, it should be known what the relative importance of each specified dose-volume constraint is for each organ at risk. This requires a greater awareness of radiobiologic properties of tissues and radiobiologic indices may help to gradually become aware of this issue

  9. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    OpenAIRE

    Beyreuther, Elke

    2010-01-01

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent t...

  10. DEGRO practical guidelines for radiotherapy of non-malignant disorders. Part I: physical principles, radiobiological mechanisms, and radiogenic risk

    International Nuclear Information System (INIS)

    Synopsis of the introductory paragraph of the DEGRO consensus S2e-guideline recommendations for the radiotherapy of benign disorders, including physical principles, radiobiological mechanisms, and radiogenic risk. This work is based on the S2e-guideline recommendations published November 14, 2013. The basic principles of radiation physics and treatment delivery, evaluation of putative underlying radiobiological mechanisms, and the assessment of genetic and cancer risk following low-dose irradiation will be presented. Radiation therapy of benign diseases is performed according to similar physical principles as those governing treatment of malignant diseases in radiation oncology, using the same techniques and workflows. These methods comprise usage of orthovoltage X-ray units, gamma irradiation facilities, linear accelerators (LINACs), and brachytherapy. Experimental in vitro and in vivo models recently confirmed the clinically observed anti-inflammatory effect of low-dose X-irradiation, and implicated a multitude of radiobiological mechanisms. These include modulation of different immunological pathways, as well as the activities of endothelial cells, mono- and polymorphonuclear leukocytes, and macrophages. The use of effective dose for radiogenic risk assessment and the corresponding tumor incidence rate of 5.5 %/Sv are currently controversially discussed. Some authors argue that the risk of radiation-induced cancers should be estimated on the basis of epidemiological data. However, such data are rarely available at present and associated with high variability. Current radiobiological studies clearly demonstrate a therapeutic effectiveness of radiation therapy used to treat benign diseases and implicate various molecular mechanisms. Radiogenic risks should be taken into account when applying radiation treatment for benign diseases. (orig.)

  11. A study of the radiobiological modeling of the conformal radiation therapy in cancer treatment

    Science.gov (United States)

    Pyakuryal, Anil Prasad

    Cancer is one of the leading causes of mortalities in the world. The precise diagnosis of the disease helps the patients to select the appropriate modality of the treatments such as surgery, chemotherapy and radiation therapy. The physics of X-radiation and the advanced imaging technologies such as positron emission tomography (PET) and computed tomography (CT) plays an important role in the efficient diagnosis and therapeutic treatments in cancer. However, the accuracy of the measurements of the metabolic target volumes (MTVs) in the PET/CT dual-imaging modality is always limited. Similarly the external beam radiation therapy (XRT) such as 3D conformal radiotherapy (3DCRT) and intensity modulated radiation therapy (IMRT) is the most common modality in the radiotherapy treatment. These treatments are simulated and evaluated using the XRT plans and the standard methodologies in the commercial planning system. However, the normal organs are always susceptible to the radiation toxicity in these treatments due to lack of knowledge of the appropriate radiobiological models to estimate the clinical outcomes. We explored several methodologies to estimate MTVs by reviewing various techniques of the target volume delineation using the static phantoms in the PET scans. The review suggests that the more precise and practical method of delineating PET MTV should be an intermediate volume between the volume coverage for the standardized uptake value (SUV; 2.5) of glucose and the 50% (40%) threshold of the maximum SUV for the smaller (larger) volume delineations in the radiotherapy applications. Similarly various types of optimal XRT plans were designed using the CT and PET/CT scans for the treatment of various types of cancer patients. The qualities of these plans were assessed using the universal plan-indices. The dose-volume criteria were also examined in the targets and organs by analyzing the conventional dose-volume histograms (DVHs). The biological models such as tumor

  12. Labor Force

    Science.gov (United States)

    Occupational Outlook Quarterly, 2012

    2012-01-01

    The labor force is the number of people ages 16 or older who are either working or looking for work. It does not include active-duty military personnel or the institutionalized population, such as prison inmates. Determining the size of the labor force is a way of determining how big the economy can get. The size of the labor force depends on two…

  13. Studies of SSNTDs made from LR-115 in view of their applicability in radiobiological experiments with alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Doerschel, B. E-mail: doerschel@physik.tu-dresden.de; Hermsdorf, D.; Pieck, S.; Starke, S.; Thiele, H.; Weickert, F

    2003-06-01

    Radiobiological studies on cell monolayers irradiated by charged particles need to determine the number and position of particle traversals. Solid state nuclear track detectors used as basic substrate for the cell layers are in principle suitable for this purpose. The detector foils must be as thin as possible but still guaranteeing mechanical stability. Two types of LR-115, red coloured and colourless, were tested in the present work. The studies aimed at optimisation of the etching conditions and determination of the registration efficiency for alpha particles in a wide range of energies and angles of incidence. Specific requirements have to be fulfilled for application of the detector foils under the environmental conditions of radiobiological experiments. Most important are biocompatibility between detector and cells and registration properties insensible against special treatments, as UV sterilisation and cell plating prior to irradiation as well as cell incubation after the irradiation. The experimental studies performed with alpha particles showed that environmental conditions of radiobiological experiments do not change the registration properties of LR-115 detectors significantly.

  14. WE-E-BRE-04: Dual Focal Spot Dose Painting for Precision Preclinical Radiobiological Investigations

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J; Lindsay, P [Princess Margaret Cancer Centre, Toronto (Canada); University of Toronto, Toronto (Canada); Jaffray, D [Princess Margaret Cancer Centre, Toronto (Canada); The Techna Institute for the Advancement of Technology for Health, Toronto (Canada)

    2014-06-15

    Purpose: Recent progress in small animal radiotherapy systems has provided the foundation for delivering the heterogeneous, millimeter scale dose distributions demanded by preclinical radiobiology investigations. Despite advances in preclinical dose planning, delivery of highly heterogeneous dose distributions is constrained by the fixed collimation systems and large x-ray focal spot common in small animal radiotherapy systems. This work proposes a dual focal spot dose optimization and delivery method with a large x-ray focal spot used to deliver homogeneous dose regions and a small focal spot to paint spatially heterogeneous dose regions. Methods: Two-dimensional dose kernels were measured for a 1 mm circular collimator with radiochromic film at 10 mm depth in a solid water phantom for the small and large x-ray focal spots on a recently developed small animal microirradiator. These kernels were used in an optimization framework which segmented a desired dose distribution into low- and high-spatial frequency regions for delivery by the large and small focal spot, respectively. For each region, the method determined an optimal set of stage positions and beam-on times. The method was demonstrated by optimizing a bullseye pattern consisting of 0.75 mm radius circular target and 0.5 and 1.0 mm wide rings alternating between 0 and 2 Gy. Results: Compared to a large focal spot technique, the dual focal spot technique improved the optimized dose distribution: 69.2% of the optimized dose was within 0.5 Gy of the intended dose for the large focal spot, compared to 80.6% for the dual focal spot method. The dual focal spot design required 14.0 minutes of optimization, and will require 178.3 minutes for automated delivery. Conclusion: The dual focal spot optimization and delivery framework is a novel option for delivering conformal and heterogeneous dose distributions at the preclinical level and provides a new experimental option for unique radiobiological investigations

  15. Radioembolisation with {sup 90}Y-microspheres: dosimetric and radiobiological investigation for multi-cycle treatment

    Energy Technology Data Exchange (ETDEWEB)

    Cremonesi, Marta; Ferrari, Mahila; Pedroli, Guido [European Institute of Oncology, Unit of Medical Physics, Milan (Italy); Bartolomei, Mirco; Arico, Demetrio; De Cicco, Concetta [European Institute of Oncology, Division of Nuclear Medicine, Milan (Italy); Orsi, Franco; Bonomo, Guido [European Institute of Oncology, Unit of Interventistic Radiology, Milan (Italy); Mallia, Andrew [Gamma Unit, Radiology Department, St. Luke' s Hospital (Malta); Paganelli, Giovanni [European Institute of Oncology, Division of Nuclear Medicine, Milan (Italy)

    2008-11-15

    Radioembolisation with {sup 90}Y-microspheres is a new locoregional treatment of hepatic lesions, usually applied as single cycle. Multi-cycle treatments might be considered as a strategy to improve the risk-benefit balance. With the aim to derive suitable information for patient tailored therapy, available patients' dosimetric data were reviewed according to the linear-quadratic model and converted into biological effective dose (BED) values. Single vs. multi-cycle approaches were compared through radiobiological perspective. Twenty patients with metastatic lesions underwent radioembolisation. The {sup 90}Y-administered activity (AA) was established in order to respect a precautionary limit dose (40 Gy) for the non-tumoral liver (NTL). BED was calculated setting {alpha}/{beta} = 2.5 Gy (NTL), 10 Gy (tumours); T{sub 1/2,eff} = T{sub 1/2,phys} = 64.2 h; T{sub 1/2,rep} = 2.5 h (NTL), 1.5 h (tumours). The BED to NTL was considered as a constraint for multi-cycle approach. The AA for two cycles and the percent variations of AA, tumour dose, BED were estimated. In one-cycle, for a prescribed BED to NTL of 64 Gy (NTL dose = 40 Gy), AA was 1.7 (0.9-3.2) GBq, tumour dose was 130 (65-235) Gy, and tumour BED was 170 (75-360) Gy. Considering two cycles, {proportional_to}15% increase was found for AA and dose to NTL, with unvaried BED for NTL. Tumour dose increase was 20 (10-35) Gy; tumour BED increase was 10 (3-11) Gy. In different protocols allowing 80 Gy to NTL, the BED sparing estimated was {proportional_to}50 Gy (two cycles) and 65 Gy (three cycles). From a radiobiological perspective, multi-cycle treatments would allow administering higher activities with increased tumour irradiation and preserved radiation effects on NTL. Trials comparing single vs. multiple cycles are suggested. (orig.)

  16. Collimator design for spatially-fractionated proton beams for radiobiology research

    Science.gov (United States)

    Lee, Eunsin; Meyer, Juergen; Sandison, George

    2016-07-01

    Preclinical and translational research is an imperative to improve the efficacy of proton radiotherapy. We present a feasible and practical method to produce spatially-modulated proton beams for cellular and small animal research for clinical and research facilities. The University of Washington (UW) 50.5 MeV proton research beamline hosting a brass collimation system was modeled using Monte Carlo simulations. This collimator consisted of an array of 2 cm long slits to cover an area of 2  ×  2 cm2. To evaluate the collimator design effects on dose rate, valley dose and the peak-to-valley dose ratios (PVDR) the following parameters were varied; slit width (0.1–1.0 mm), peak center-to-center distance (1–3 mm), collimator thickness (1–7 cm) and collimator location along the beam axis. Several combinations of slit widths and 1 mm spacing achieved uniform dose at the Bragg peak while maintaining spatial modulation on the beam entrance. A more detailed analysis was carried out for the case of a slit width of 0.3 mm, peak center-to-center distance of 1 mm, a collimator thickness of 5 cm and with the collimator flush against the water phantom. The dose rate at 5 mm depth dropped relative to an open field by a factor of 12 and produced a PVDR of 10.1. Technical realization of proton mini-beams for radiobiology small animal research is demonstrated to be feasible. It is possible to obtain uniform dose at depth while maintaining reasonable modulation at shallower depths near the beam entrance. While collimator design is important the collimator location has a strong influence on the entrance region PVDRs and on dose rate. These findings are being used to manufacture a collimator for installation on the UW cyclotron proton beam nozzle. This collimator will enable comparative studies on the radiobiological efficacy of x-rays and proton beams.

  17. An in vitro study of the radiobiological effects of flattening filter free radiotherapy treatments

    International Nuclear Information System (INIS)

    Flattening filter free (FFF) linear accelerators allow for an increase in instantaneous dose-rate of the x-ray pulses by a factor of 2–6 over the conventional flattened output. As a result, radiobiological investigations are being carried out to determine the effect of these higher dose-rates on cell response. The studies reported thus far have presented conflicting results, highlighting the need for further investigation. To determine the radiobiological impact of the increased dose-rates from FFF exposures a Varian Truebeam medical linear accelerator was used to irradiate two human cancer cell lines in vitro, DU-145 prostate and H460 non-small cell lung, with both flattened and FFF 6 MV beams. The fluence profile of the FFF beam was modified using a custom-designed Nylon compensator to produce a similar dose profile to the flattened beam (6X) at the cell surface but at a higher instantaneous dose-rate. For both cell lines there appeared to be no significant change in cell survival. Curve fitting coefficients for DU145 cells irradiated with constant average dose-rates were 6X: α = 0.09 ± 0.03, β = 0.03 ± 0.01 and 6FFF: α = 0.14 ± 0.13, β = 0.03 ± 0.02 with a significance of p = 0.75. For H460 cells irradiated with the same instantaneous dose-rate but different average dose-rate the fit coefficients were 6FFF (low dose-rate): α = 0.21 ± 0.11, 0.07 ± 0.02 and 6FFF (high dose-rate): α = 0.21 ± 0.16, 0.07 ± 0.03, with p = 0.79. The results indicate that collective damage behaviour does not occur at the instantaneous dose-rates investigated here and that the use of either modality should result in the same clinical outcome, however this will require further validation in vivo. (note)

  18. An in vitro study of the radiobiological effects of flattening filter free radiotherapy treatments

    Science.gov (United States)

    King, R. B.; Hyland, W. B.; Cole, A. J.; Butterworth, K. T.; McMahon, S. J.; Redmond, K. M.; Trainer, C.; Prise, K. M.; McGarry, C. K.; Hounsell, A. R.

    2013-03-01

    Flattening filter free (FFF) linear accelerators allow for an increase in instantaneous dose-rate of the x-ray pulses by a factor of 2-6 over the conventional flattened output. As a result, radiobiological investigations are being carried out to determine the effect of these higher dose-rates on cell response. The studies reported thus far have presented conflicting results, highlighting the need for further investigation. To determine the radiobiological impact of the increased dose-rates from FFF exposures a Varian Truebeam medical linear accelerator was used to irradiate two human cancer cell lines in vitro, DU-145 prostate and H460 non-small cell lung, with both flattened and FFF 6 MV beams. The fluence profile of the FFF beam was modified using a custom-designed Nylon compensator to produce a similar dose profile to the flattened beam (6X) at the cell surface but at a higher instantaneous dose-rate. For both cell lines there appeared to be no significant change in cell survival. Curve fitting coefficients for DU145 cells irradiated with constant average dose-rates were 6X: α = 0.09 ± 0.03, β = 0.03 ± 0.01 and 6FFF: α = 0.14 ± 0.13, β = 0.03 ± 0.02 with a significance of p = 0.75. For H460 cells irradiated with the same instantaneous dose-rate but different average dose-rate the fit coefficients were 6FFF (low dose-rate): α = 0.21 ± 0.11, 0.07 ± 0.02 and 6FFF (high dose-rate): α = 0.21 ± 0.16, 0.07 ± 0.03, with p = 0.79. The results indicate that collective damage behaviour does not occur at the instantaneous dose-rates investigated here and that the use of either modality should result in the same clinical outcome, however this will require further validation in vivo.

  19. Study on a 7-DOF anthropomorphic weld arm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A kind of new obstacle space expression is proposed in this paper, in which a virtual force field (VFF) is built. Using the torque and joint optimization acted by the virtual force field on the anthropomorphic weld arm, the real-time selection of a redundant join (R-joint) is done and its equivalent virtual torque is obtained, thus the redundant joint can be controlled with whose force feedback. An inverse kinematics solution of a 6-DOF robot is applied to other six joints of the arm. Simulation experiments indicate the new inverse kinematics solution has perfect collision avoidance effect, and it is well simplified. Therefore, it can be applied to a welding task in complex operation space.

  20. X-Armed Bandits

    CERN Document Server

    Bubeck, Sébastien; Stoltz, Gilles; Szepesvari, Csaba

    2010-01-01

    We consider a generalization of stochastic bandits where the set of arms, $\\cX$, is allowed to be a generic measurable space and the mean-payoff function is "locally Lipschitz" with respect to a dissimilarity function that is known to the decision maker. Under this condition we construct an arm selection policy, called HOO hierarchical optimistic optimization), with improved regret bounds compared to previous results for a large class of problems. In particular, our results imply that if $\\cX$ is the unit hypercube in a Euclidean space and the mean-payoff function has a finite number of global maxima around which the behavior of the function is locally H\\"older continuous with a known exponent, then the expected of HOO regret is bounded up to a logarithmic factor by $\\sqrt{n}$, i.e., the rate of growth of the regret is independent of the dimension of the space. We also prove the minimax optimality of our algorithm when the dissimilarity is a metric.

  1. Development of Integrated ASR Model Forcing Data and Their Applications to Improve CAM

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Minghua [Research Foundation of the State University of New York, Albany, NY (United States)

    2016-01-01

    In this project, we have (1) improved the constrained variational analysis algorithm of ARM model forcing data, and (2) used the ARM forcing data to identify systematic biases in clouds and radiation in the CAM5 and design new physical parameterizations to improve it.

  2. Dispersion Forces

    CERN Document Server

    Buhmann, Stefan Yoshi

    2012-01-01

    In this book, a modern unified theory of dispersion forces on atoms and bodies is presented which covers a broad range of advanced aspects and scenarios. Macroscopic quantum electrodynamics is shown to provide a powerful framework for dispersion forces which allows for discussing general properties like their non-additivity and the relation between microscopic and macroscopic interactions. It is demonstrated how the general results can be used to obtain dispersion forces on atoms in the presence of bodies of various shapes and materials. Starting with a brief recapitulation of volume I, this volume II deals especially with bodies of irregular shapes, universal scaling laws, dynamical forces on excited atoms, enhanced forces in cavity quantum electrodynamics, non-equilibrium forces in thermal environments and quantum friction. The book gives both the specialist and those new to the field a thorough overview over recent results in the field. It provides a toolbox for studying dispersion forces in various contex...

  3. The Influences of Arm Resist Motion on a CAR Crash Test Using Hybrid III Dummy with Human-Like Arm

    Science.gov (United States)

    Kim, Yongchul; Youm, Youngil; Bae, Hanil; Choi, Hyeonki

    Safety of the occupant during the crash is very essential design element. Many researches have been investigated in reducing the fatal injury of occupant. They are focusing on the development of a dummy in order to obtain the real human-like motion. However, they have not considered the arm resist motion during the car accident. In this study, we would like to suggest the importance of the reactive force of the arm in a car crash. The influences of reactive force acting on the human upper extremity were investigated using the impedance experimental method with lumped mass model of hand system and a Hybrid III dummy with human-like arm. Impedance parameters (e.g. inertia, spring constant and damping coefficient) of the elbow joint in maximum activation level were measured by free oscillation test using single axis robot. The results showed that without seat belt, the reactive force of human arm reduced the head, chest, and femur injury, and the flexion moment of the neck is higher than that of the conventional dummy.

  4. LISA Long-Arm Interferometry

    Science.gov (United States)

    Thorpe, James I.

    2009-01-01

    An overview of LISA Long-Arm Interferometry is presented. The contents include: 1) LISA Interferometry; 2) Constellation Design; 3) Telescope Design; 4) Constellation Acquisition; 5) Mechanisms; 6) Optical Bench Design; 7) Phase Measurement Subsystem; 8) Phasemeter Demonstration; 9) Time Delay Interferometry; 10) TDI Limitations; 11) Active Frequency Stabilization; 12) Spacecraft Level Stabilization; 13) Arm-Locking; and 14) Embarassment of Riches.

  5. Dosimetric measurements and radiobiological consequences of radioimmunotherapy in tumor bearing mice

    International Nuclear Information System (INIS)

    With the development of the hybridoma technology, the production of highly specific tumor associated monoclonal antibodies has provided new optimism for the adjuvant delivery of therapeutic radiation doses via radioimmunotherapy. The authors have used a modified form of the well-established TL dosimetry technology to measure the dose resulting from radioimmunotherapy experiments in tumor bearing mice. Their laboratory has designed and tested a miniature CaSO4:D TLD which fits conveniently inside a 20 gauge needle for the direct implantation of the dosimeter in an animal model undergoing radiolabeled antibody therapy. Direct measurement of absorbed dose from beta and gamma radiation in the animals may be obtained upon removal of the dosimeter at animal sacrifice or by surgery. This absorbed dose data may then be related to antibody affinity and localization data obtained by serial biodistribution studies. Using p96.5 melanoma antibody with a Brown Tumor Model in athymic mice, localization indices measured in the range of 2 to 4 and scored 4 to 7 days post antibody injection, yielded a tumor dose/whole body dose ratio of 1.10 +/- 0.04 (no enhancement). The dose to liver showed marker time-dependent enhancement relative to the whole body, however. An outline of suggested control radiobiological experiments to be performed in conjunction with radioimmunotherapy experiments has been included in order to provide comparative dose response data. 11 references, 14 figures, 3 tables

  6. Impact of microgravity on radiobiological processes and efficiency of DNA repair

    Energy Technology Data Exchange (ETDEWEB)

    Horneck, G. [Radiation Biology Division, Institute of Aerospace Medicine, DLR German Aerospace Center, Linder Hohe, 51170 Cologne (Germany)

    1999-12-06

    To study the influence of microgravity on radiobiological processes in space, space experiments have been performed, using an on-board 1xg reference centrifuge as in-flight control. The trajectory of individual heavy ions was localized in relation to the biological systems by use of the Biostack concept, or an additional high dose of radiation was applied either before the mission or during the mission from an on-board radiation source. In embryonic systems, such as early developmental stages of Drosophila melanogaster and Carausius morosus, the occurrence of chromosomal translocations and larval malformations was dramatically increased in response to microgravity and radiation. It has been hypothesized that these synergistic effects might be caused by an interference of microgravity with DNA repair processes. However, recent studies on bacteria, yeast cells and human fibroblasts suggest that a disturbance of cellular repair processes in the microgravity environment might not be a complete explanation for the reported synergism of radiation and microgravity. As an alternative explanation, an impact of microgravity on signal transduction, on the metabolic/physiological state or on the chromatin structure at the cellular level, or modification of self-assembly, intercellular communication, cell migration, pattern formation or differentiation at the tissue and organ level should be considered.

  7. Impact of radiobiological considerations on epidemiological inferences of age-dependent radiosensitivity

    International Nuclear Information System (INIS)

    Current epidemiological studies of the age-dependent risk of radiogenic carcinomas are based on populations still in the early stages of cancer expression. The result is a set of logical uncertainties concerning the manner in which inferences may be drawn from the existing data. These uncertainties may be formalized and examined through the application of various radiobiological principles developed from more fundamental experimental data. Chief amongst these considerations are the time course of tumor expression, the role of relative and absolute risk models, the distribution of effects between initiation and promotion, the age-dependent fraction of time a critical cell remains in radiosensitive stages and the combinatorics of the critical cellular subpopulations. Each of these and the combinatorics of the critical cellular subpopulations. Each of these principles are examined in light of their impact on the structuring of epidemiologic data and the drawing of inferences concerning age-dependent radiogenic risk. The data on atomic bomb survivors are employed as a relevant example

  8. Radiobiology of Small Hive Beetle (Coleoptera: Nitidulidae) and Prospects for Management Using Sterile Insect

    International Nuclear Information System (INIS)

    Small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is considered a serious threat to beekeeping in the Western Hemisphere, Australia, and Europe mainly due to larval feeding on honey, pollen, and brood of the European honeybee, Apis mellifera L. Control methods are limited for this pest. Studies were conducted to provide information on the radiobiology of small hive beetle and determine the potential for sterile insect releases as a control strategy. Adult males and females were equally sensitive to a radiation dose of 80 Gy and died within 5–7 d after treatment. In reciprocal crossing studies, irradiation of females only lowered reproduction to a greater extent than irradiation of males only. For matings between unirradiated males and irradiated females, mean reproduction was reduced by >99% at 45 and 60 Gy compared with controls, and no larvae were produced at 75 Gy. Irradiation of prereproductive adults of both sexes at 45 Gy under low oxygen (1–4%) caused a high level of sterility (>99%) while maintaining moderate survivorship for several weeks, and should suffice for sterile insect releases. Sterile insect technique holds potential for suppressing small hive beetle populations in newly invaded areas and limiting its spread. (author)

  9. Development of a single ion micro-irradiation facility for experimental radiobiology at cell level

    International Nuclear Information System (INIS)

    A micro-irradiation device has been developed for radiobiology applications at the scale of the cell. This device is based on an upgrade of an existing micro-beam line that was already able to deliver a 1 to 3 MeV proton or alpha beam of low intensity and whose space resolution is lower than 1 micrometer in vacuum. The important part of this work has been the development of an irradiation stage designed to fit on the micro-probe and able to deliver ions in the air with an absolute accuracy of a few micrometers. A program has been set up to monitor the complete irradiation line in testing and in automatic irradiation operating phases. Simulation tools based on Monte-Carlo calculations have been validated through comparisons with experimental data particularly in the field of spatial resolution and of the number of ions delivered. The promising results show the possibility in a near future to use this tool to study the response of cells to very low irradiation doses down to the extreme limit of one ion per cell

  10. Postoperative radiotherapy in DBCG during 30 years. Techniques, indications and clinical radiobiological experience

    Energy Technology Data Exchange (ETDEWEB)

    Overgaard, Marie; Juul Christensen, Jens (Dept. of Oncology and Dept. of Medical Physics, Aarhus Univ. Hospital, Aarhus (Denmark))

    2008-05-15

    During the time period 1977-2007 postoperative radiotherapy in DBCG has varied considerably with regard to techniques and indications together with changes in the extent of surgery and adjuvant systemic therapy. The radiation treatment has been developed on the basis of clinical, radiophysical and radiobiological principles, encompassing also practical problems such as available equipment in the different centres and at times lack of sufficient machine capacity. The paper focus especially on the comprehensive work done prior to the DBCG 82 b and c studies, in order to optimize radiotherapy in all aspects prior to the evaluation of the efficacy of this treatment modality. The results from these trials did succeed in clear evidence that radiotherapy has an important role in the multidisciplinary treatment of early breast cancer. In parallel to these studies a new and challenging use of radiotherapy after breast conserving surgery was evaluated in the DBCG TM 82 protocol. The experience obtained with different techniques in this study formed the basis for the current principles of radiotherapy after lumpectomy. Reduction of radiation related morbidity has been a major issue for the DBCG radiotherapy group, and in this aspect several studies, including quality control visits, have been carried out to make the relevant modifications and to evaluate deviations from the guidelines between the centres. The background for the changes in radiotherapy is described for each of the programme periods as well as future perspectives which will include further refinements of the target and adjustments of dose and fractionation in selected patients

  11. Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer

    Directory of Open Access Journals (Sweden)

    Marcu Loredana

    2009-01-01

    Full Text Available Head and neck cancer represents a challenge for radiation oncologists due to accelerated repopulation of cancer cells during treatment. This study aims to simulate, using Monte Carlo methods, the response of a virtual head and neck tumor to both conventional and altered fractionation schedules in radiotherapy when accelerated repopulation is considered. Although clinical trials are indispensable for evaluation of novel therapeutic techniques, they are time-consuming processes which involve many complex and variable factors for success. Models can overcome some of the limitations encountered by trials as they are able to simulate in less complex environment tumor cell kinetics and dynamics, interaction processes between cells and ionizing radiation and their outcome. Conventional, hyperfractionated and accelerated treatment schedules have been implemented in a previously developed tumor growth model which also incorporates tumor repopulation during treatment. This study focuses on the influence of three main treatment-related parameters, dose per fraction, inter fraction interval and length of treatment gap and gap timing based on RTOG trial data on head and neck cancer, on tumor control. The model has shown that conventionally fractionated radiotherapy is not able to eradicate the stem population of the tumor. Therefore, new techniques such as hyperfractionated/ accelerated radiotherapy schedules should be employed. Furthermore, the correct selection of schedule-related parameters (dose per fraction, time between fractions, treatment gap scheduling is crucial in overcoming accelerated repopulation. Modeling of treatment regimens and their input parameters can offer better understanding of the radiobiological interactions and also treatment outcome.

  12. Radiation-induced cataract-genesis: pathophysiologic, radiobiological and clinical aspects

    International Nuclear Information System (INIS)

    Cataract-genesis is a widely reported late effect of irradiated crystalline lens. In this review the authors discussed the different aspects of radiation cataract pathogenesis, and the different mechanisms involved in the lens opacification, particularly the epithelium modifications such as epithelial cell death. The authors also reported the influence of radiation exposure on cataract formation following total body irradiation TBI) and autologous or allogeneic bone marrow transplantation for hematologic malignancies. Moreover, the radiobiological parameters are not studied for the crystalline lens of human. We applied for the first time the linear quadratic (LQ) and biological effective dose (BED) concept to TBI data. The calculated value of α/β of 1 Gy is in the range of the values reported for the other late responding tissues. The other risk factors for cataract development after TBI such as age, gender, central nervous system boost, long-term steroid therapy and heparin administration are discussed. In terms of cataract or sicca syndrome prevention, numerous compounds have been successfully tested in experimental models or used for the prevention of radiation-induced xerostomia in patients treated for head and neck cancer. However, none of them has been clinically evaluated for ocular radiation late effects prevention. In this report the authors discussed some of the radioprotectors potentially interesting for radiation-induced cataract or sicca syndrome prevention. (author)

  13. Osteopontin and splice variant expression level in human malignant glioma: Radiobiologic effects and prognosis after radiotherapy

    International Nuclear Information System (INIS)

    Background and purpose: We investigated the role of the hypoxia-associated secreted glycoprotein osteopontin (OPN) in the response of malignant glioma to radiotherapy by characterizing OPN and its splice variants in vitro and in patient material. Material and methods: The effect of siRNA knockdown of OPN splice variants on cellular and radiobiologic behavior was analyzed in U251MG cells using OpnS siRNA (inhibition of all OPN splice variants) and OpnAC siRNA (knockdown only of OPNa and OPNc). OPN and splice variant mRNA levels were quantified in archival material of 41 glioblastoma tumor samples. Plasma OPN was prospectively measured in 33 malignant glioma patients. Results: Inhibition of OPNa and OPNc (OpnAC) reduced clonogenic survival in U251MG cells but did not affect proliferation, migration or apoptosis. Knockdown of all OPN splice variants (OpnS) resulted in an even stronger inhibition of clonogenic survival, while cell proliferation and migration were reduced and rate of apoptosis was increased. Additional irradiation had additive effects with both siRNAs. Plasma OPN increased continuously in malignant glioma patients and was associated with poor survival. Conclusions: OPNb is partially able to compensate the effects of OPNa and OPNc knockdown in U251MG cells. High OPN plasma levels at the end of radiotherapy are associated with poor survival

  14. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy.

    Science.gov (United States)

    Champion, C; Quinto, M A; Monti, J M; Galassi, M E; Weck, P F; Fojón, O A; Hanssen, J; Rivarola, R D

    2015-10-21

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies. PMID:26406277

  15. Radiobiological investigation on the ray induced sterilization of east worm (Grapholita molesta busc., lepidoptera:tortricidae)

    International Nuclear Information System (INIS)

    Results of radiobiological investigations on the sterilizing effect of the ionizing radiation, used to treat pupae and imagines of the oriental fruit moth (G. molesta) are reported. The irradiation is realized with gamma rays (60Co) of 12-13 Gy/s (±5%). The parameters of the induced sterility are determined differently for male and female specimen. The sterilizing effect of gamma radiation on male specimen irradiated as pupae and adults results in lethal spermatozoa mutations. The functional interrelation (dose-dominant lethals) is described by curves of a mixed type, consisting of a linear and non-linear component. The established dynamics in the frequency of the mutations in the dose range suggests that the optimum sterilizing ray doses are in the range 400-500 Gy. Doses below 500 Gy (pupae) and 450 Gy (imago) do not reduce considerably the life of the male butterflies. The sterilizing effect on the female specimen after pupae and imagines irradiation is due to dominant lethal mutations in the oocytes. The interrelation (dose-dominant lethals) is described by curves of sigmoid configuration. The absolutely sterilizing dose for both ontogenic stages is 150 Gy. The irradiation of the female specimen causes partial sterility along with the induction of dominant lethals in the ovules

  16. Environmental Research Division annual report: Center for Human Radiobiology, July 1983-June 1984. Part 2

    International Nuclear Information System (INIS)

    Epidemiological studies of the late effects of internal radium in man, and mechanistic investigations of those effects, have continued. The current status of the study is summarized. An experimental technique for preparing thin sections of bone and the application of that technique in studying the comparative distribution of radium and plutonium are described. Radiological dental changes due to radium in man and dog are compared. Survival of human fibroblasts irradiated with alpha particles in vitro was found to be higher when the average LET was higher. In the study of the late effects of thorium in man, the relative activities of the daughter products in the lung have been determined spectrometrically in vivo. The exhalation of thoron in these persons has been investigated in relation to lung burden of thorium and to personal factors such as smoking, age, and weight. The administration of two isotopes to large mammals has been used to demonstrate that the metabolism of plutonium is independent of route of entry and to determine the gastrointestinal absorption of plutonium. The effect of thermoluminescence on a scintillation radon counting system has been investigated quantitatively. Data on the exposure of 88 persons to radium were added to the data base, bringing the total to 2400 radium cases under study by the Center for Human Radiobiology. Separate abstracts were prepared for individual papers

  17. Bucharest cyclotron as intense fast neutron source for radiobiological and analytical applications

    International Nuclear Information System (INIS)

    Due to interest for applications in radiobiology and material testing, Bucharest U-120 classical variable energy Cyclotron is employed as an intense source of fast neutrons, using 13.5 MeV deuterons bombarding a Beryllium target placed at 20 deg against the incident beam. Energy spectra, yields, average energy and irradiation doses were determined using time-of-flight (TOF), multiple foils and thermoluminescent detectors (TLD) methods. The average energy is 5.24 MeV. The total yield at 0 deg, obtained by summing up the yields for neutron energies between the lower (0.3 MeV) and upper (17 MeV) thresholds, is 6.7 x 1016 n/sr.C.MeV. The yield of the low energy component (0.3-2 MeV) is 1.88 x 1016 n/sr.C.MeV, i.e. 28% of the total yield at 0 deg. We present studies on the influence of thyotepa, thyroxine, metallic ions (Cs1+ and AL3+) and D3 vitamin on fast neutron radiolysis in tumor DNA conclusions on the role of thyotepa (accelerator for tumor destruction) and of thyroxine, metallic ions and D3 vitamin (protectors). The potential for elemental analysis, especially for light elements (O, Na, Mg, Al, Si) on archaeological glass and ceramics objects is discussed. (authors)

  18. The challenge for the paradigms heat have guided the radiobiology in the past

    International Nuclear Information System (INIS)

    Until recently, it has been commonly accepted that the biological consequences following ionizing radiation exposure are attributable to direct DNA damage. However, in the last decade some evidence have emerged to suggest that the classical genetic effects associated with radiation exposure (i.e. mutations, chromosomal aberrations, micronucleus) are not necessarily the result of the direct damage induced in the cellular DNA. These effects have been termed non-targeted and include radiation-induced genomic instability, effects detected after cytoplasmic irradiation and bystander effects. All of them support the hypothesis that important genetic consequences of radiation may arise in cells that in themselves receive no direct radiation exposure at all. The radioinduced damage signals could be transmitted to these cells from those that have been directly irradiated. The non-targeted effects challenge the paradigms that have guided radiobiology in the past and may change our thinking about the early events in the carcinogenic process and in particular about the critical targets for genetic and carcinogenic damage by radiation. These effects could be particularly important at low doses, when non all the cells are directly exposed to an ionizing track. (Author) 45 refs

  19. Radiobiological characterization of different energy-photon beams used in radiotherapy from linear accelerator

    International Nuclear Information System (INIS)

    The main objective of this study was to perform a radiobiological characterization of different energy photon beams (6 MV and 15 MV) from linear accelerator used in radiotherapy, and comparison of different treatment modalities, with special regard to late effects of radiation. Using two end points, cell survival and micronucleus induction, in the biological system (Chines hamster V79 cell line). Chromosomes number was counted and found to be 22 chromosomes per cell. Cells were kept in confluent growth for two days and then exposed to two photon beams and immediately after irradiation were counted and re seeded in different numbered for each dose. For evaluation of surviving fraction samples were incubated at 37oC for 6 days, five samples were counted for each dose. At the same time three samples were seeded for the micronuclei frequency and incubated at 37oC after 24 hours cytochalasin-B was added to block cells in cytokinesis. The survival curve showed similar curves for the two beams and decreased with dose. The micronuclei frequency was positively correlated with dose and the energy of the photon. This indicates the presence of low dose of photoneutrons produced by using high energy photon beams. (Author)

  20. Neutron flux characterisation of the Pavia TRIGA Mark II research reactor for radiobiological and microdosimetric applications.

    Science.gov (United States)

    Alloni, D; Prata, M; Salvini, A; Ottolenghi, A

    2015-09-01

    Nowadays the Pavia TRIGA reactor is available for national and international collaboration in various research fields. The TRIGA Mark II nuclear research reactor of the Pavia University offers different in- and out-core neutron irradiation channels, each characterised by different neutron spectra. In the last two years a campaign of measurements and simulations has been performed in order to guarantee a better characterisation of these different fluxes and to meet the demands of irradiations that require precise information on these spectra in particular for radiobiological and microdosimetric studies. Experimental data on neutron fluxes have been collected analysing and measuring the gamma activity induced in thin target foils of different materials irradiated in different TRIGA experimental channels. The data on the induced gamma activities have been processed with the SAND II deconvolution code and finally compared with the spectra obtained with Monte Carlo simulations. The comparison between simulated and measured spectra showed a good agreement allowing a more precise characterisation of the neutron spectra and a validation of the adopted method. PMID:25958412

  1. Radiograaff, a proton irradiation facility for radiobiological studies at a 4 MV Van de Graaff accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Constanzo, J. [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, F-69622 Villeurbanne (France); Fallavier, M., E-mail: m.fallavier@ipnl.in2p3.fr [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, F-69622 Villeurbanne (France); Alphonse, G. [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); Faculté de Médecine Lyon-Sud, LRCM, F-69921 Oullins (France); Hospices-Civils-de-Lyon, CHLS, F-69495 Pierre-Bénite (France); Bernard, C. [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, F-69622 Villeurbanne (France); Battiston-Montagne, P. [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); Faculté de Médecine Lyon-Sud, LRCM, F-69921 Oullins (France); Rodriguez-Lafrasse, C. [Université de Lyon, F-69622, Lyon (France); Université Lyon 1, Villeurbanne (France); Faculté de Médecine Lyon-Sud, LRCM, F-69921 Oullins (France); Hospices-Civils-de-Lyon, CHLS, F-69495 Pierre-Bénite (France); and others

    2014-09-01

    A horizontal beam facility for radiobiological experiments with low-energy protons has been set up at the 4 MV Van de Graaff accelerator of the Institut de Physique Nucléaire de Lyon. A homogeneous irradiation field with a suitable proton flux is obtained by means of two collimators and two Au-scattering foils. A monitoring chamber contains a movable Faraday cup, a movable quartz beam viewer for controlling the intensity and the position of the initial incident beam and four scintillating fibers for beam monitoring during the irradiation of the cell samples. The beam line is ended by a thin aluminized Mylar window (12 μm thick) for the beam extraction in air. The set-up was simulated by the GATE v6.1 Monte-Carlo platform. The measurement of the proton energy distribution, the evaluation of the fluence-homogeneity over the sample and the calibration of the monitoring system were performed using a silicon PIPS detector, placed in air in the same position as the biological samples to be irradiated. The irradiation proton fluence was found to be homogeneous to within ±2% over a circular field of 20 mm diameter. As preliminary biological experiment, two Human Head and Neck Squamous Carcinoma Cell lines (with different radiosensitivities) were irradiated with 2.9 MeV protons. The measured survival curves are compared to those obtained after X-ray irradiation, giving a Relative Biological Efficiency between 1.3 and 1.4.

  2. Radiograaff, a proton irradiation facility for radiobiological studies at a 4 MV Van de Graaff accelerator

    International Nuclear Information System (INIS)

    A horizontal beam facility for radiobiological experiments with low-energy protons has been set up at the 4 MV Van de Graaff accelerator of the Institut de Physique Nucléaire de Lyon. A homogeneous irradiation field with a suitable proton flux is obtained by means of two collimators and two Au-scattering foils. A monitoring chamber contains a movable Faraday cup, a movable quartz beam viewer for controlling the intensity and the position of the initial incident beam and four scintillating fibers for beam monitoring during the irradiation of the cell samples. The beam line is ended by a thin aluminized Mylar window (12 μm thick) for the beam extraction in air. The set-up was simulated by the GATE v6.1 Monte-Carlo platform. The measurement of the proton energy distribution, the evaluation of the fluence-homogeneity over the sample and the calibration of the monitoring system were performed using a silicon PIPS detector, placed in air in the same position as the biological samples to be irradiated. The irradiation proton fluence was found to be homogeneous to within ±2% over a circular field of 20 mm diameter. As preliminary biological experiment, two Human Head and Neck Squamous Carcinoma Cell lines (with different radiosensitivities) were irradiated with 2.9 MeV protons. The measured survival curves are compared to those obtained after X-ray irradiation, giving a Relative Biological Efficiency between 1.3 and 1.4

  3. Radiobiology of Small Hive Beetle (Coleoptera: Nitidulidae) and Prospects for Management Using Sterile Insect Releases.

    Science.gov (United States)

    Downey, Danielle; Chun, Stacey; Follett, Peter

    2015-06-01

    Small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is considered a serious threat to beekeeping in the Western Hemisphere, Australia, and Europe mainly due to larval feeding on honey, pollen, and brood of the European honeybee, Apis mellifera L. Control methods are limited for this pest. Studies were conducted to provide information on the radiobiology of small hive beetle and determine the potential for sterile insect releases as a control strategy. Adult males and females were equally sensitive to a radiation dose of 80 Gy and died within 5-7 d after treatment. In reciprocal crossing studies, irradiation of females only lowered reproduction to a greater extent than irradiation of males only. For matings between unirradiated males and irradiated females, mean reproduction was reduced by >99% at 45 and 60 Gy compared with controls, and no larvae were produced at 75 Gy. Irradiation of prereproductive adults of both sexes at 45 Gy under low oxygen (1-4%) caused a high level of sterility (>99%) while maintaining moderate survivorship for several weeks, and should suffice for sterile insect releases. Sterile insect technique holds potential for suppressing small hive beetle populations in newly invaded areas and limiting its spread. PMID:26470205

  4. Decontamination activities at the National Institute of Oncology and Radiobiology in Havana, Cuba

    International Nuclear Information System (INIS)

    The National Institute of Oncology and Radiobiology had a facility contaminated with 137Cs. The contamination was produced by a leaking source stored in the place. First decontamination work was performed in 1988. Some highly contaminated floor tiles and other contaminated items were removed. Spent sealed sources stored in the facility were collected. The facility was closed because of the remaining contamination. As the Regulatory Body allowed the unrestricted use of the facility, decontamination and decommissioning were needed. D and D activities were requested to the CPHR. Contamination surveys conducted in 1999 confirmed the extent of contamination with 137Cs. Items inside the contaminated area were carefully monitored and segregated. Six Radium sources were recovered. Physical and chemical methods of decontamination were used. For different reasons, the requirements established by the Regulatory Authority for decommissioning could not be achieved, and therefore the facility could not be released from regulatory control. A Radiological Status Report was done explaining the high cost of decontamination according to the established clearance levels. New alternatives were then proposed for decommissioning of this facility. (author)

  5. Differential two colour X-ray radiobiology of membrane/cytoplasm yeast cells

    International Nuclear Information System (INIS)

    This report describes the experiment entitled 'Differential Two Colour X-Ray Radiobiology of Membrane/Cytoplasm Yeast Cells'; carried out at the Central Laser Facility (CLF) from the 6th January to the 3rd February 1997. The experiment, funded by the Framework IV Large-Scale Facilities Access Scheme, was proposed by Dr. M. Milani, Dipartimento di Scienza dei Materiali, University of Milan, Italy, and carried out by visiting researchers from his institute, the University of Modena and with technical support from the Central Laser Facility, Rutherford Appleton Laboratory. Experimental highlights: The development of an investigation technique based on the use of very soft X-ray in order to damage specific structures inside the cell structure (specifically cell wall and membrane); the use of pressure sensors as a diagnostics of cell response which allows to monitor cell response over a large range of times from fast response up to several hours; the use of dry yeast cells as an 'easy to handle' type of sample; the development of a simple model for X-ray dosimetry of the different cell compartments; the study of metabolic oscillation in yeast cell suspension and the observation of the oscillation frequency shift following an exposure to soft X-rays. (author)

  6. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy

    International Nuclear Information System (INIS)

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence—expressed in terms of total cross sections—as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies. (paper)

  7. Neutron flux characterisation of the Pavia Triga Mark II research reactor for radiobiological and microdosimetric applications

    International Nuclear Information System (INIS)

    Nowadays the Pavia TRIGA reactor is available for national and international collaboration in various research fields. The TRIGA Mark II nuclear research reactor of the Pavia University offers different in- and out-core neutron irradiation channels, each characterised by different neutron spectra. In the last two years a campaign of measurements and simulations has been performed in order to guarantee a better characterisation of these different fluxes and to meet the demands of irradiations that require precise information on these spectra in particular for radiobiological and microdosimetric studies. Experimental data on neutron fluxes have been collected analysing and measuring the gamma activity induced in thin target foils of different materials irradiated in different TRIGA experimental channels. The data on the induced gamma activities have been processed with the SAND II deconvolution code and finally compared with the spectra obtained with Monte Carlo simulations. The comparison between simulated and measured spectra showed a good agreement allowing a more precise characterisation of the neutron spectra and a validation of the adopted method. (authors)

  8. Dosimetric validation of the MCNPX Monte Carlo simulation for radiobiologic studies of megavoltage grid radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To validate the MCNPX Monte Carlo simulation for radiobiologic studies of megavoltage grid radiotherapy. Methods and Materials: EDR2 films, a scanning water phantom with microionization chamber and MCNPX Monte Carlo code, were used to study the dosimetric characteristics of a commercially available megavoltage grid therapy collimator. The measured dose profiles, ratios between maximum and minimum doses at 1.5 cm depth, and percentage depth dose curve were compared with those obtained in the simulations. The simulated two-dimensional dose profile and the linear-quadratic formalism of cell survival were used to calculate survival statistics of tumor and normal cells for the treatment of melanoma with a list of doses of the fractionated grid therapy. Results: A good agreement between the simulated and measured dose data was found. The therapeutic ratio based on normal cell survival has been defined and calculated for treating both the acute and late responding melanoma tumors. The grid therapy in this study was found to be advantageous for treating the acutely responding tumors, but not for late responding tumors. Conclusions: Monte Carlo technique was demonstrated to be able to provide the dosimetric characteristics for grid therapy. The therapeutic ratio was dependent not only on the single α/β value, but also on the individual α and β values. Acutely responding tumors and radiosensitive normal tissues are more suitable for using the grid therapy

  9. 33 CFR 334.680 - Gulf of Mexico, southeast of St. Andrew Bay East Entrance, small-arms firing range, Tyndall Air...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico, southeast of St. Andrew Bay East Entrance, small-arms firing range, Tyndall Air Force Base, Fla. 334.680 Section 334.680..., small-arms firing range, Tyndall Air Force Base, Fla. (a) The danger zones—(1) Area No. 1. The waters...

  10. Update: malaria, U.S. Armed Forces, 2011.

    Science.gov (United States)

    2012-01-01

    U.S. service members are at risk of malaria when they are assigned to endemic areas (e.g., Korea), participate in operations in endemic areas (e.g., Afghanistan, Africa) and visit malarious areas during personal travel. In 2011, 124 service members were reported with malaria. Nearly three-fourths of cases were presumably acquired in Afghanistan (n=91) and one-fifth were considered acquired in Africa (n=24). One-quarter of cases were caused by P. vivax and one-fifth by P. falciparum (including 6 Afghanistan-acquired infections); most cases were reported as "unspecified" malaria. Malaria was diagnosed/reported from 51 different medical facilities in the United States, Afghanistan, Kyrgyzstan, Iraq, Germany and Korea. Providers of care to military members should be knowledgeable regarding and vigilant for clinical presentations of malaria outside of endemic areas. PMID:22309389

  11. The influence of demography on European and future Armed Forces

    OpenAIRE

    Stemmer, Ekkehard

    2005-01-01

    Such demographic factors in Europe as low fertility rates, high life expectancy, and the restricted immigration policy have caused European societies to age rapidly and the population of Europe will dramatically decline over the next thirty years. In comparison to Europe, the trend of aging in developing counties, for example in the Middle East and Northern Africa, presents a stark contrast. Taking into account demographic trends like aging, global distribution of the population, and migratio...

  12. Mobilization and Defence plans of the Latvian Armed forces

    Index Scriptorium Estoniae

    Kuzmins, Valdis

    2013-01-01

    Esimesel iseseisvusperioodil töötati välja kolm kaitseplaani, igaühega neist kaasnes mobilisatsiooniplaan. Rahvusvahelise olukorra muutudes töötati ka välja neljas mobilisatsiooniplaan ja alustati viienda mobilisatsiooniplaani väljatöötamist, mida ei jõutud aga lõpetada

  13. Internationally recognised armed forces / Urmas Roosimägi

    Index Scriptorium Estoniae

    Roosimägi, Urmas

    1999-01-01

    Eesti Kaitseväe juhataja kohusetäitja kolonel Urmas Roosimägi Eesti kaitseväest, osalemisest NATO-PFP (NATO-Partnership for Peace) programmis ja sõjalisest koostööst NATO partnerriikidega. Urmas Roosimägi biograafia. Programm Partnerlus Rahu Nimel

  14. Nuclear arms cleanup

    International Nuclear Information System (INIS)

    The Soviet Union's demise five years ago brought an end to the Cold War, the 45-year arms race between the Soviet superpower and the United States. The euphoria that greeted the end of this bloodless conflict has dampened somewhat, however, as U.S. officials and their counterparts in the former Soviet republics come to grips with its legacy: thousands of highly toxic and politically destabilizing nuclear weapons. With no more perceived need for much of their vast arsenals, the governments have agreed to dismantle large numbers of nuclear warheads. But the agencies involved in this task face a daunting technical and political problem: what to do with the thousands of tons of plutonium and uranium that are the main ingredients of nuclear weapons

  15. Force sensing

    OpenAIRE

    Sanders, David

    2007-01-01

    A young child can explore and learn and compensate for unknown dynamics by prodding, pushing, touching, grasping and feeling. Force sensing and software research could soon allow artificial mechanisms to do the same. Force sensing has its roots in strain gauges, piezoelectrics, Wheatstone bridges, automation, robotics, grippers and virtual reality. That force sensing research has now become commonplace and has expanded from those roots to include so much more: video games, athletic equipment,...

  16. Treatment of Glioma Using neuroArm Surgical System

    Science.gov (United States)

    2016-01-01

    The use of robotic technology in the surgical treatment of brain tumour promises increased precision and accuracy in the performance of surgery. Robotic manipulators may allow superior access to narrow surgical corridors compared to freehand or conventional neurosurgery. This paper reports values and ranges of tool-tissue interaction forces during the performance of glioma surgery using an MR compatible, image-guided neurosurgical robot called neuroArm. The system, capable of microsurgery and stereotaxy, was used in the surgical resection of glioma in seven cases. neuroArm is equipped with force sensors at the end-effector allowing quantification of tool-tissue interaction forces and transmits force of dissection to the surgeon sited at a remote workstation that includes a haptic interface. Interaction forces between the tool tips and the brain tissue were measured for each procedure, and the peak forces were quantified. Results showed maximum and minimum peak force values of 2.89 N (anaplastic astrocytoma, WHO grade III) and 0.50 N (anaplastic oligodendroglioma, WHO grade III), respectively, with the mean of peak forces varying from case to case, depending on type of the glioma. Mean values of the peak forces varied in range of 1.27 N (anaplastic astrocytoma, WHO grade III) to 1.89 N (glioblastoma with oligodendroglial component, WHO grade IV). In some cases, ANOVA test failed to reject the null hypothesis of equality in means of the peak forces measured. However, we could not find a relationship between forces exerted to the pathological tissue and its size, type, or location. PMID:27314044

  17. The objective qualification of non-international armed conflicts: A Colombian case study

    Directory of Open Access Journals (Sweden)

    Sebastian Machado

    2012-02-01

    Full Text Available

    Armed conflict has raged in Colombia since at least the 1960’s, involving governmental forces, rebel groups, and paramilitary forces. The Uribe government (2002-2010 declared that Colombia was not in a ‘state of armed conflict’ but was rather facing a ‘terrorist threat’. This declaration was done in fear of conferring a political status to the armed groups, and most particularly, in fear that a recognition of armed conflict would open the possibility of endowing the Revolutionary Armed Forces of Colombia (FARC with a ‘belligerency status’. From a legal point of view, the government’s fears were unfounded, since contemporary international humanitarian law does not require a formal for a situation to qualify as armed conflict. During the Uribe administration, efforts were made by the Ministry of Defense to identify operational rules of engagement with precision, violations of international humanitarian law were publicly denounced, and the apex courts adjudicated on issues of international humanitarian law. This seemingly paradoxical situation illustrates the importance of the objective definition of armed conflict, which has been a defining characteristic of international humanitarian law since 1949.

     

  18. Multijoint arm stiffness during movements following stroke: implications for robot therapy

    Science.gov (United States)

    Piovesan, D.; Casadio, M.; Mussa-Ivaldi, F. A.; Morasso, P.G

    2015-01-01

    Impaired arm movements in stroke appear as a set of stereotypical kinematic patterns, characterized by abnormal joint coupling, which have a direct consequence on arm mechanics and can be quantified by the net arm stiffness at the hand. The current available measures of arm stiffness during functional tasks have limited clinical use, since they require several repetitions of the same test movement in many directions. Such procedure is difficult to obtain in stroke survivors who have lower fatigue threshold and increased variability compared to unimpaired individuals. The present study proposes a novel, fast quantitative measure of arm stiffness during movements by means of a Time-Frequency technique and the use of a reassigned spectrogram, applied on a trial-by-trial basis with a single perturbation. We tested the technique feasibility during robot mediated therapy, where a robot helped stroke survivors to regain arm mobility by providing assistive forces during a hitting task to 13 targets covering the entire reachable workspace. The endpoint stiffness of the paretic arm was estimated at the end of each hitting movements by suddenly switching of the assistive forces and observing the ensuing recoil movements. In addition, we considered how assistive forces influence stiffness. This method will provide therapists with improved tools to target the treatment to the individual’s specific impairment and to verify the effects of the proposed exercises. PMID:22275576

  19. DOE/CEC [Department of Energy/Commission of the European Communities] workshop on critical evaluation of radiobiological data to biophysical modeling

    International Nuclear Information System (INIS)

    The Department of Energy's Office of Health and Environmental Research and the Commission of the European Communities (CEC) Radiation Protection Program support the majority of Research in the Field of Radiobiological Modeling. This field of science develops models based on scientifically sound principles to predict biological response (at the cellular, molecular, and animal level) to exposure to low level ionizing radiation. Biophysical models are an important tool for estimating response of ionizing radiation at low doses and dose rates. Generally speaking, the biophysical models can be classified into two groups: (1) mechanistic models and (2) phenomenological models. Mechanistic models are based on some assumptions about the physical, chemical, or biological mechanisms of action in association with radiobiological data whereas the phenomenological models are based solely on available experimental data on radiobiological effects with less emphasis on mechanisms of action. There are a number of these models which are being developed. Since model builders rely on radiobiological data available in the literature either to develop mechanistic or phenomenological models, it is essential that a critical evaluation of existing radiobiological data be made and data that is generally considered good and most appropriate for biophysical modeling be identified. A Workshop jointly sponsored by the DOE and the CEC was held at Oak Ridge, Tennessee from June 23--25, 1988, to review the data available from physical and chemical, cellular and molecular and animal studies with ionizing radiation

  20. Development of a multisensory arm for process monitoring in Robot Assisted Polishing

    DEFF Research Database (Denmark)

    Pilny, Lukas; Dalla Costa, Giuseppe; Bissacco, Giuliano;

    2015-01-01

    A multisensory polishing arm with integrated three component force sensor, a miniature acoustic emission (AE) sensor and an accelerometer was developed for process monitoring in Robot Assisted Polishing (RAP) process. The arm design was optimized for integration of a force and an AE sensor....... The force sensor, consisted of semiconductor and metallic strain gauges, was calibrated by means of static application of defined loads. The sensor performance in a dynamic application was subsequently verified by comparison with a reference calibrated dynamometer on a dedicated test rig. To compensate...