WorldWideScience

Sample records for armed forces radiobiology

  1. 77 FR 68155 - The Armed Forces Radiobiology Research Institute TRIGA Reactor: Facility Operating License No. R-84

    Science.gov (United States)

    2012-11-15

    ... NRC's E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to... filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28, 2007) apply to appeals of NRC... COMMISSION The Armed Forces Radiobiology Research Institute TRIGA Reactor: Facility Operating License No....

  2. Biological effects of embedded depleted uranium (DU). Summary of Armed Forces Radiobiology Research Institute research

    International Nuclear Information System (INIS)

    The Persian Gulf War resulted in injuries of US Coalition personnel by fragments of depleted uranium (DU). Fragments not immediately threatening the health of the individuals were allowed to remain in place, based on long-standing treatment protocols designed for other kinds of metal shrapnel injuries. However, questions were soon raised as to whether this approach is appropriate for a metal with the unique radiological and toxicological properties of DU. The Armed Forces Radiobiology Research Institute (AFRRI) is investigating health effects of embedded fragments of DU to determine whether current surgical fragment removal policies remain appropriate for this metal. These studies employ rodents implanted with DU pellets as well as cultured human cells exposed to DU compounds. Results indicate uranium from implanted DU fragments distributed to tissues far-removed from implantation sites, including bone, kidney, muscle, and liver. Despite levels of uranium in the kidney that were nephrotoxic after acute exposure, no histological or functional kidney toxicity was observed. However, results suggest the need for further studies of long-term health impact, since DU was found to be mutagenic, and it transformed human osteoblast cells to a tumorigenic phenotype. It also altered neurophysiological parameters in rat hippocampus, crossed the placental barrier, and entered fetal tissue. This report summarizes AFRRI's depleted uranium research to date

  3. Safety-Evaluation Report related to the renewal of the operating license for the research reactor at the Armed Forces Radiobiology Research Institute. Docket No. 50-170

    International Nuclear Information System (INIS)

    Supplement 1 to the Safety Evaluation Report related to the renewal of the operating license for the research reactor at the Armed Forces Radiobiology Research Institute has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The reactor facility is located in Montgomery County, Maryland. This supplement reports on the status of the licensee's emergency plan that had not been reviewed at the time the Safety Evaluation Report (NUREG-0882) was published

  4. AFRRI (Armed Forces Radiobiology Research Institute) reports, April-June 1985. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The following titles are included in this collection of reprints: Presence of a high-affinity Ca(s+) - and Mg(2+) - dependent ATPase in rat peritoneal mast-cell membranes; Prostanoid production by lipopolysaccharide stimulated Kupffer cells; Antihistamines block radiation-induced increased intestinal blood flow in canines; WR-2721 inhibition of radiation-induced prostaglandin excretion in rats; Effects of mixed neutron-gamma total-body irradiation on physical activity performance of rhesus monkeys; Immunologic and hematologic perturbations in models of combined injury; Hematopoiesis in conventional mice after wound trauma; Carrier generation recombination, and transport in organic crystals; Energy transfer and molecular weight effects on polymer luminescence. Keywords: Radiobiology; Military research.

  5. Radiobiology

    International Nuclear Information System (INIS)

    This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, scientific workers and physicians. (author)

  6. Modernization of African Armed Forces

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    2015-01-01

    Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa.......Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa....

  7. Ranking the European armed forces

    NARCIS (Netherlands)

    Beeres, R.J.M.; Bogers, M.

    2012-01-01

    The degree of collectiveness aimed for in European defence policy raises issues such as burden sharing and relative performance measurement of the European Armed Forces (EAF). This paper compares EAF performance rates on three dimensions: input, throughput and output. In order to express performance

  8. Gender Integration and the Swedish Armed Forces

    DEFF Research Database (Denmark)

    Gustafsson, Daniel Marcus Sunil

    This paper discusses different gender aspects of the Swedish Armed Forces with specific references to sexual harassment and prostitution. By using the concept of Hegemonic Masculinity, sexual harassment of the women in the Swedish Armed Forces is explained in terms of a need of the men within...

  9. Homosexuality in the Dutch Armed Forces 2006

    NARCIS (Netherlands)

    Anna Adolfsen; Saskia Keuzenkamp; m.m.v. Linda Mans

    2006-01-01

    Original title: Uniform uit de kast. This study looks at the attitudes of defence personnel to homosexuality. How do members of the military view homosexual colleagues? Can gays and lesbians working in the armed forces be open about their sexual preferences? Do they regard the armed forces as a gay

  10. 78 FR 30731 - Armed Forces Day, 2013

    Science.gov (United States)

    2013-05-22

    ... hundred and thirty- seventh. (Presidential Sig.) [FR Doc. 2013-12402 Filed 5-21-13; 11:15 am] Billing code..., liberty, and the pursuit of happiness. And on Armed Forces Day, we honor those who serve bravely...

  11. Diversity in the Danish Armed Forces

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John; Pradhan-Blach, Flemming; Larsen, Esben Salling;

    The Danish Armed Forces face the functional imperative of becoming a smaller, professional expeditionary force and the societal imperative of including women and ethnic minorities. It currently lags behind its NATO partners in gender and ethnic diversity. Lessons to be learned from NATO members...... and realistic goals, systematically developing recruitment, development, and retention policies, and the superiority of an all-volunteer force over conscription in fulfilling this societal imperative....

  12. Homosexuality in the Dutch Armed Forces 2006

    OpenAIRE

    Anna Adolfsen; Saskia Keuzenkamp; m.m.v. Linda Mans

    2006-01-01

    Original title: Uniform uit de kast. This study looks at the attitudes of defence personnel to homosexuality. How do members of the military view homosexual colleagues? Can gays and lesbians working in the armed forces be open about their sexual preferences? Do they regard the armed forces as a gay-friendly workplace, or do they have lots of negative experiences? At the request of the State Secretary for Defence, the Netherlands Institute for Social Research/SCP carried out a study on the acc...

  13. Optimizing Armed Forces Capabilities for Hybrid Warfare – New Challenge for Slovak Armed Forces

    Directory of Open Access Journals (Sweden)

    Peter PINDJÁK

    2015-09-01

    Full Text Available The paper deals with the optimization of military capabilities of the Slovak Armed Forces for conducting operations in a hybrid conflict, which represents one of the possible scenarios of irregular warfare. Whereas in the regular warfare adversaries intend to eliminate the centers of gravity of each other, most often command and control structures, in irregular conflicts, the center of gravity shifts towards the will and cognitive perception of the target population. Hybrid warfare comprises a thoroughly planned combination of conventional military approaches and kinetic operations with subversive, irregular activities, including information and cyber operations. These efforts are often accompanied by intensified activities of intelligence services, special operation forces, and even mercenary and other paramilitary groups. The development of irregular warfare capabilities within the Slovak Armed Forces will require a progressive transformation process that may turn the armed forces into a modern and adaptable element of power, capable of deployment in national and international crisis management operations.

  14. Proximal arm kinematics affect grip force-load force coordination.

    Science.gov (United States)

    Vermillion, Billy C; Lum, Peter S; Lee, Sang Wook

    2015-10-01

    During object manipulation, grip force is coordinated with load force, which is primarily determined by object kinematics. Proximal arm kinematics may affect grip force control, as proximal segment motion could affect control of distal hand muscles via biomechanical and/or neural pathways. The aim of this study was to investigate the impact of proximal kinematics on grip force modulation during object manipulation. Fifteen subjects performed three vertical lifting tasks that involved distinct proximal kinematics (elbow/shoulder), but resulted in similar end-point (hand) trajectories. While temporal coordination of grip and load forces remained similar across the tasks, proximal kinematics significantly affected the grip force-to-load force ratio (P = 0.042), intrinsic finger muscle activation (P = 0.045), and flexor-extensor ratio (P joint cannot fully explain the observed changes, as task-related changes in intrinsic hand muscle activation were greater than in extrinsic hand muscles. Rather, between-task variation in grip force (highest during task 3) appears to contrast to that in shoulder joint velocity/acceleration (lowest during task 3). These results suggest that complex neural coupling between the distal and proximal upper extremity musculature may affect grip force control during movements, also indicated by task-related changes in intermuscular coherence of muscle pairs, including intrinsic finger muscles. Furthermore, examination of the fingertip force showed that the human motor system may attempt to reduce variability in task-relevant motor output (grip force-to-load force ratio), while allowing larger fluctuations in output less relevant to task goal (shear force-to-grip force ratio). PMID:26289460

  15. Gravitoinertial force level influences arm movement control

    Science.gov (United States)

    Fisk, J.; Lackner, J. R.; DiZio, P.

    1993-01-01

    1. The ability to move the forearm between remembered elbow joint angles immediately after rapid increases or decreases of the background gravitoinertial force (G) level was measured. The movements had been well-practiced in a normal 1G environment before the measurements in high-(1.8G) and low-force (0G) environments. The forearm and upper arm were always unsupported to maximize the influence of altered G-loading and to minimize extraneous cues about arm position. 2. Horizontal and vertical movement planes were studied to measure the effects of varying the G load in the movement plane within a given G background. Rapid and slow movements were studied to assess the role of proprioceptive feedback. 3. G level did not affect the amplitude of rapid movements, indicating that subjects were able to plan and to generate appropriate motor commands for the new G loading of the arm. The amplitude of slow movements was affected by G level, indicating that proprioceptive feedback is influenced by G level. 4. The effects of G level were similar for horizontal and vertical movements, indicating that proprioceptive information from supporting structures, such as the shoulder joint and muscles, had a role in allowing generation of the appropriate motor commands. 5. The incidence and size of dynamic overshoots were greater in 0G and for rapid movements. This G-related change in damping suggests a decrease in muscle spindle activity in 0G. A decrease in muscle spindle activity in 0G and an increase in 1.8G are consistent with the results of our prior studies on the tonic vibration reflex, locomotion, and perception of head movement trajectory in varying force backgrounds.

  16. The professionalisation of the Netherlands armed force

    OpenAIRE

    Van Veldhuizen-Rothenbuecher, Ida

    2001-01-01

    The fall of the Berlin Wall and the end of the Cold War led in 1991 to the decision to gradually reduce and restructure the Netherlands armed forces. It was process consisting of dozens of reorganisations. The idea was that the reorganisation and reduction would go hand in hand, not only operationally but also financially. Firstly, only one in three men were actually still called up in order to fulfil conscription duties lasting more or less a year. There was one more condition for the transf...

  17. Professional armed forces new trend in Europe : transformation of the Czech armed forces

    OpenAIRE

    Zold, Zoltan

    2002-01-01

    Approved for public release; distribution is unlimited In 2001 the Czech Republic decided to abandon conscription in favor of professional armed forces. Western European countries are following the same trend, since the new security environment requires quickly deployable, highly skilled and well-equipped forces. The current round of reforms started with Belgium and Netherlands, and have seen followed by France, Spain, Italy and Portugal. These countries are beneficiary from experience in ...

  18. ARMED FORCES AND INTERVENTION IN TROPICAL AFRICA

    Directory of Open Access Journals (Sweden)

    L. Steyn

    2012-02-01

    Full Text Available "The Ghana Armed Forces, in co-operation with the police, have thought it necessary to take over the reins of power and to dismiss the former President, Kwame Nkrumah, the Presidential Commission and all Ministers, and to suspend the Constitution and to dissolve Parliament. This act has been necessitated by the political and economic situation in the country. The concentration of power in the hands of one man has led to the abuse of individual rights and liberty. Power has been exercised by the former President capriciously. The operation of the laws has been suspended to the advantage of his favourites and he has been running the country as his own personal property. "

  19. Information operations, an evolutionary step for the Mexican Armed Forces

    OpenAIRE

    Schulz, David Vargas

    2007-01-01

    This thesis will focus on the Mexican Armed Force's ability to deal with existing and future unconventional threats and insurgencies. The modern Mexican Armed Forces are the result of an enduring evolutionary process, which has made the necessary changes to deal with the emerging threats against the state. Mexico's criminal threat has evolved because of 9/11 and because of the U.S.-led crackdown on Colombian drug cartels. Mexico's modern adversary is well versed in waging mass media campa...

  20. Procurement, Storage and Distribution of Foodstuff in the Armed Forces

    OpenAIRE

    Y. D. Sahasrabuddhe

    1984-01-01

    The problem of procuring, storing and distributing foodstuffs to the Armed Forces in India is a stupendous task because of the wide variations interrains and climatic conditions and the varied food habits of the people. It is all the more exacting as the processed food industry is still in its infancy. Because of the stringent quality control requirements of the Armed Forces, the food processing industry in India is not willing to undertake supplies to the Defence services. The problems and h...

  1. AFRRI (Armed Forces Radiobiology Research Institute) reports, April-June 1989. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1989-07-01

    This volume contains AFRRI Scientific Reports Sr89-15 through SR89-25 for April-June 1989. Subjects include: Radiation quality and rat motor performance; Gamma-radiation affects: active electrolyte transport by rabbit ileum II; Correlation of alanine and theophylline response with morphology; effects of iron particles on behavioral and brain function: Initial studies; Correlative motor behavioral and striatal dopaminergic alterations induced by Fe iron radiation; The effect of radiation on DNA methylation; Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia; Oxidation damage in the guinea pig hippocampal slice; Radiation-induced volatile hydrocarbon production in platelets: Long-term culture of canine bone marrow cells; Radioprotection of mouse hematopoietic stem cells by leukotriene A4 and lipoxin B4; and Selective association and transport of Campylobacter jejuni through M cells of rabbit Peyer's patches.

  2. AFRRI (Armed Forces Radiobiology Research Institute) reports, January, February and March 1988. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    A possible mechanism by which disodium cromoglycate (DSCG) prevents a decrease in regional cerebral blood flow but not hypotension in primates following whole body gamma irradiation was studied. Several studies have implicated superoxide radicals in intestinal and cerebral vascular disorders following ischemia and ionizing radiation, respectively, The superoxide radical is formed during radiolysis in the reaction between hydrated electrons and dissolved oxygen. For this reason, the efficiency of DSCG to scavenge hydrated electrons and possibly prevent the formation of the superoxide radical was studied. The results show that DSCG is an efficient hydrated-electrons scavenger and may effectively compete with oxygen for hydrated electrons preventing the radiolytic formation of the superoxide radicals.

  3. AFRRI (Armed Forces Radiobiology Research Institute) reports, July-September 1985. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The following titles are included in this collection of reprints: Characterization of radiation induced performance decrement using a two-lever shock-avoidance task; Fluorescence kinetics of emission from a small finite volume of a biological system; Effect of ionizing radiation on gastric secretion and gastric motility in monkeys; Radiation effects on diamine oxidase activities in intestine and plasma of the rat; Wound-induced alterations in survival of /sup 60/Co irradiated mice - importance of wound timing; Quaternary naltrexone reverses morphine-induced behaviors; Electronic processes in organic solids.

  4. Problems of feeding the armed forces

    Directory of Open Access Journals (Sweden)

    B. C. Ray Sarkar

    1952-01-01

    Full Text Available The main problems encountered in the proper supply of foodstuffs for the maintenance of defence forces relate to procurement, preservation and storage of food stuffs and their supply and transport on one hand, evaluation of nutritional requirement to the forces engaged in different kinds of work and designing of rations to serve specific purposes on the other. Apart from-these problems which are quite broad in nature, there are others of specific character

  5. Procurement, Storage and Distribution of Foodstuff in the Armed Forces

    Directory of Open Access Journals (Sweden)

    Y. D. Sahasrabuddhe

    1984-04-01

    Full Text Available The problem of procuring, storing and distributing foodstuffs to the Armed Forces in India is a stupendous task because of the wide variations interrains and climatic conditions and the varied food habits of the people. It is all the more exacting as the processed food industry is still in its infancy. Because of the stringent quality control requirements of the Armed Forces, the food processing industry in India is not willing to undertake supplies to the Defence services. The problems and how they are handled are briefly reviewed.

  6. Exoskeleton arm with force feedback for robot bilateral teleoperation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A novel 6 degrees of freedom (DOFs) wearable exoskeleton arm, ZJUESA, based on man-machine system is presented. It can be used in robot bilateral teleoperation as master arm with force-feedback. With introducing the revolute-prismatic-spherical(RPS) parallel mechanism and planetary gear mechanism, it is designed based on the anatomy of human upper-limb. With the sensors on this external mechanical structure, the human operator motion is detected and converted to the slave robot control command. Additionally the pneumatic system on it generates a force feedback by using hybrid fuzzy control. As a result, the human operator may have a feeling of doing the work directly.

  7. A model of psychological resilience for the Netherlands Armed Forces

    NARCIS (Netherlands)

    Kamphuis, W.; Venrooij, W.; Berg, C. van den

    2012-01-01

    In the current study, a model of psychological resilience was developed for the Netherlands Armed Forces and a number of important relations were tested using a longitudinal design. The model of resilience was based on a systematic literature review of resilience in high-risk professions and intervi

  8. Basic radiobiology

    International Nuclear Information System (INIS)

    Radiobiology, a branch of science concerned with the action of ionizing radiation on biological tissues and living organisms, is a combination of two disciplines: radiation physics and biology. For use in radiobiology and radiation protection the physical quantity that is useful for defining the quality of an ionizing radiation beam is the linear energy transfer (LET). In contrast to the stopping power, which focuses attention on the energy loss by an energetic charged particle moving through a medium, the LET focuses attention on the linear rate of energy absorption by the absorbing medium as the charged particle traverses the medium. When cells are exposed to ionizing radiation the standard physical effects between radiation and the atoms or molecules of the cells occur first and the possible biological damage to cell functions follows later. The biological effects of radiation result mainly from damage to the DNA, which is the most critical target within the cell; however, there are also other sites in the cell that, when damaged, may lead to cell death

  9. [The Italian armed forces health service during the Great War].

    Science.gov (United States)

    De Caro, Walter; Marucci, Anna Rita; Sansoni, Julita

    2014-06-01

    The Great War had a huge impact on Italian society. The organisation of the armed forces health service faced extreme difficulties due to the extensive loss of life of an almost exclusively terrestrial war. In this context, the role of the medical staff and nursing staff was essential, as the example of the volunteer Red Cross nurses testifies. However, this conflict revealed the need to improve the training of the nursing staff, as was the case in Anglo-Saxon countries.

  10. Rapid adaptation to Coriolis force perturbations of arm trajectory.

    Science.gov (United States)

    Lackner, J R; Dizio, P

    1994-07-01

    1. Forward reaching movements made during body rotation generate tangential Coriolis forces that are proportional to the cross product of the angular velocity of rotation and the linear velocity of the arm. Coriolis forces are inertial forces that do not involve mechanical contact. Virtually no constant centrifugal forces will be present in the background when motion of the arm generates transient Coriolis forces if the radius of body rotation is small. 2. We measured the trajectories of arm movements made in darkness to a visual target that was extinguished as movement began. The reaching movements were made prerotation, during rotation at 10 rpm in a fully enclosed rotating room, and postrotation. During testing the subject was seated at the center of the room and pointed radially. Neither visual nor tactile feedback about movement accuracy was present. 3. In experiment 1, subjects reached at a fast or slow rate and their hands made contact with a horizontal surface at the end of the reach. Their initial perrotary movements were highly significantly deviated relative to prerotation in both trajectories and end-points in the direction of the transient Coriolis forces that had been generated during the reaches. Despite the absence of visual and tactile feedback about reaching accuracy, all subjects rapidly regained straight movement trajectories and accurate endpoints. Postrotation, transient errors of opposite sign were present for both trajectories and endpoints. 4. In a second experiment the conditions were identical except that subjects pointed just above the location of the extinguished target so that no surface contact was involved. All subjects showed significant initial perrotation deviations of trajectories and endpoints in the direction of the transient Coriolis forces. With repeated reaches the trajectories, as viewed from above, again became straight, but there was only partial restoration of endpoint accuracy, so that subjects reached in a straight

  11. Rapid adaptation to Coriolis force perturbations of arm trajectory

    Science.gov (United States)

    Lackner, J. R.; Dizio, P.

    1994-01-01

    1. Forward reaching movements made during body rotation generate tangential Coriolis forces that are proportional to the cross product of the angular velocity of rotation and the linear velocity of the arm. Coriolis forces are inertial forces that do not involve mechanical contact. Virtually no constant centrifugal forces will be present in the background when motion of the arm generates transient Coriolis forces if the radius of body rotation is small. 2. We measured the trajectories of arm movements made in darkness to a visual target that was extinguished as movement began. The reaching movements were made prerotation, during rotation at 10 rpm in a fully enclosed rotating room, and postrotation. During testing the subject was seated at the center of the room and pointed radially. Neither visual nor tactile feedback about movement accuracy was present. 3. In experiment 1, subjects reached at a fast or slow rate and their hands made contact with a horizontal surface at the end of the reach. Their initial perrotary movements were highly significantly deviated relative to prerotation in both trajectories and end-points in the direction of the transient Coriolis forces that had been generated during the reaches. Despite the absence of visual and tactile feedback about reaching accuracy, all subjects rapidly regained straight movement trajectories and accurate endpoints. Postrotation, transient errors of opposite sign were present for both trajectories and endpoints. 4. In a second experiment the conditions were identical except that subjects pointed just above the location of the extinguished target so that no surface contact was involved. All subjects showed significant initial perrotation deviations of trajectories and endpoints in the direction of the transient Coriolis forces. With repeated reaches the trajectories, as viewed from above, again became straight, but there was only partial restoration of endpoint accuracy, so that subjects reached in a straight

  12. STRATEGIC MANAGEMENT OF HUMAN RESOURCE AND THE SLOVAK ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Jaroslav NEKORANEC

    2014-04-01

    Full Text Available Human resource management is an important area of strategic management of the organization which focuses on everything that concerns people. The main role of human resource management is to contribute to organizational performance and its continuous improvement. In order to fulfill the aims and objectives of the organization, it is necessary that organization top management has a clear-cut view of human resource management strategies that would work in practice. One of the most important and most challenging aspects of human resource management can be applied also in organizations characterized by specific features such as the Armed Forces of the Slovak Republic.

  13. Human arm posture prediction in response to isometric endpoint forces.

    Science.gov (United States)

    Davoudabadi Farahani, Saeed; Andersen, Michael Skipper; de Zee, Mark; Rasmussen, John

    2015-11-26

    The ability to predict the musculoskeletal response to external loads has multiple applications for the design of machines with a human interface and for the prediction of outcomes of musculoskeletal interventions. In this study, we applied an inverse-inverse dynamics technique to investigate its ability to predict arm posture in response to isometric hand forces. For each subject, we made a three-dimensional musculoskeletal model using the AnyBody Modelling System (AMS). Then, we had each subject-specific model hold a weight anteriorly to the right shoulder joint at a distance of half of the arm length. We selected the glenohumeral abduction angle (GHAA) as the only free parameter. Subsequently, we used inverse-inverse dynamics to find the optimal GHAA that minimised a performance criterion with physiological constraints. In this study, we investigated the performance of two different objective functions: summation of squared muscle activity (SSMA) and summation of squared normalised joint torques (SSNJT). To validate the simulation results, arm posture responses to different isometric downward hand forces were measured for six healthy male subjects. Five trials were performed for each loading condition. The results showed that, with an increase in hand load, there was a reduced GHAA in all subjects. Another interesting finding was that self-selected postures for lighter tasks varied more than postures for heavier tasks for all subjects. To understand this, we investigated the curvature of the objective function as a function of the load and observed an increased curvature with increased load. This may explain the reduced intra-subject variations observed for increasing loads.

  14. Human arm posture prediction in response to isometric endpoint forces.

    Science.gov (United States)

    Davoudabadi Farahani, Saeed; Andersen, Michael Skipper; de Zee, Mark; Rasmussen, John

    2015-11-26

    The ability to predict the musculoskeletal response to external loads has multiple applications for the design of machines with a human interface and for the prediction of outcomes of musculoskeletal interventions. In this study, we applied an inverse-inverse dynamics technique to investigate its ability to predict arm posture in response to isometric hand forces. For each subject, we made a three-dimensional musculoskeletal model using the AnyBody Modelling System (AMS). Then, we had each subject-specific model hold a weight anteriorly to the right shoulder joint at a distance of half of the arm length. We selected the glenohumeral abduction angle (GHAA) as the only free parameter. Subsequently, we used inverse-inverse dynamics to find the optimal GHAA that minimised a performance criterion with physiological constraints. In this study, we investigated the performance of two different objective functions: summation of squared muscle activity (SSMA) and summation of squared normalised joint torques (SSNJT). To validate the simulation results, arm posture responses to different isometric downward hand forces were measured for six healthy male subjects. Five trials were performed for each loading condition. The results showed that, with an increase in hand load, there was a reduced GHAA in all subjects. Another interesting finding was that self-selected postures for lighter tasks varied more than postures for heavier tasks for all subjects. To understand this, we investigated the curvature of the objective function as a function of the load and observed an increased curvature with increased load. This may explain the reduced intra-subject variations observed for increasing loads. PMID:26482735

  15. OPTIMIZATION OF FINANCIAL PERSONNEL NUMBER IN ARMED FORCES OF THE REPUBLIC OF BELARUS

    OpenAIRE

    A. V. Bolshakova

    2014-01-01

    The paper considers a problem pertaining to reduction of the Armed Forces of the Republic of Belarus and necessity to carry out economically reasonable reforms optimizing strength of financial personnel with the purpose to decrease its number but without undermining financial and operational activities of the Armed Forces as a whole. It has been proposed to optimize strength of financial personnel in the Armed Forces while executing organizational staff transformations such as introduction of...

  16. SECURITY AND DEFENCE SOURCES FOR THE ARMED FORCES OF THE SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Milan SOPÓCI

    2015-04-01

    Full Text Available The article deals with some aspects of security and defence sources for the armed forces of the Slovak Republic. It compares the possibilities of several NATO states in terms of their Gross National Product (GNP and their expenses for the armed forces. The article refers to the negative impingement of expenses reduction on the position of the SR and the Slovak armed forces developed with its NATO and EU partners. It also focuses on the possibilities to obtain funding sources for the development of armed forces from special NATO programmes.

  17. DRUG USE ATTITUDE OF TURKISH ARMED FORCES PILOTS

    Directory of Open Access Journals (Sweden)

    Ahmet SEN

    Full Text Available Introduction: Because of the dangers in the nature of flight, pilots have to fly in perfect medical conditions. Besides the undesirable effects of the diseases, side effects of the medications used in the treatment might also risk flight safety. In this study, we investigated the drug use attitude of Turkish Armed Forces pilots. Material-Method: In order to investigate their drug use attitude, a questionnaire was given to 408 pilots at GATA Aerospace Medical Center. Drug use attitude, drugs used by pilots and side effects were questioned. Results: 41 % of pilots reported that they used drugs during active flying. But the drug use rate of Army pilots was 57 %, which was higher than the Air Force and Navy pilots. The most common used drugs were analgesics. Conclusion: It is obvious that pilots might use drugs without informing their flight surgeon. Flight surgeons should always educate the pilots about the importance and dangers of self-medication. [TAF Prev Med Bull 2004; 3(9.000: 213-220

  18. Gender Integration and the Swedish Armed Forces:The Case of Sexual Harassment and Prostitution

    OpenAIRE

    Gustafsson, Daniel Marcus Sunil

    2006-01-01

    This paper discusses different gender aspects of the Swedish Armed Forces with specific references to sexual harassment and prostitution. By using the concept of Hegemonic Masculinity, sexual harassment of the women in the Swedish Armed Forces is explained in terms of a need of the men within the organisation to reinforce the notion of women as inferior and subordinate to men, whereby the external hegemony is believed to be restored. Likewise, male Swedish peacekeepers’ demand for prostitutio...

  19. Radiobiological Research in JINR

    CERN Document Server

    Krasavin, E A

    2000-01-01

    The results of long-term radiobiological and radiation-genetical research in DRRR (Division of Radiobiology) are summarized. The different radiation-induced effects in bacteria, yeasts, mammalian and human cells after irradiation by gamma-rays and heavy charged particles are considered. The important role of DNA repair processes in biological effectiveness of different types of radiation were shown. The data on mutagenic action of such kinds of radiation on pro- and eukaryotic cells were analyzed. On the basis of our data the hypersensitivity of human and mammalian chromosomes after low doses of gamma-rays (10-20 sGy) was revealed. The radiobiological effect of ^{211}At - methylene blue complex on human melanoma cells was studied. The extremely high effectiveness of this complex on melanoma cells was shown.

  20. Queen Margarethe II Wants You! Diversity in the Danish Armed Forces

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    The Danish Armed Forces face the functional imperative of becoming a smaller, professional expeditionary force and the societal imperative of including women and ethnic minorities. It currently lags behind its NATO partners in gender and ethnic diversity. Lessons to be learned from NATO members...... and realistic goals, systematically developing recruitment, development, and retention policies, and the superiority of an all-volunteer force over conscription in fulfilling this societal imperative....

  1. Automatic identification technology tracking weapons and ammunition for the Norwegian Armed Forces

    OpenAIRE

    Lien, Tord Hjalmar.

    2011-01-01

    Approved for public release; distribution is unlimited. The purpose of this study is to recommend technology and solutions that improve the accountability and accuracy of small arms and ammunition inventories in the Norwegian Armed Forces (NAF). Radio Frequency Identification (RFID) and Item Unique Identification (IUID) are described, and challenges and benefits of these two major automatic identification technologies are discussed. A case study for the NAF is conducted where processes a...

  2. Conventional forces and arms control: Technology and strategy in a changing world

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, J.F.; White, P.C.

    1990-06-01

    To address the implications of changes for future roles of conventional forces and to assess the technology implications of future strategies, force requirements, and conventional arms control agreements, the Center for National Security Studies in cooperation with the Defense Research and Applications Directorate of the Los Alamos National Laboratory held a conference on Conventional Forces and Arms Control: Technology and Strategy in a Changing World'' at Los Alamos from September 25--27, 1989. The distinguished participants from government, industry, and academia in the United States and Western Europe addressed such issues as: What are the implications of geopolitical and technological trends for international security and stability How will these global changes affect US and allied strategies and force structure, especially the requirements for conventional, nonnuclear forces What will be the role of and rationale for conventional forces in the context of current and prospective allied security requirements How can the West assure it will have the forces necessary for its security How will technological developments influence the structure of tomorrow's conventional forces What impacts will arms reductions have on future systems and force structures What are the prospects for the development and deployment in weapon systems of future conventional military technologies, in light of existing and potential political, economic, bureaucratic, and other impediments

  3. Military compensation in the Armenian Armed Forces: life cycle cost model for the Armenian Army

    OpenAIRE

    zurLippe, Jan-Hendrik C.

    2013-01-01

    Approved for public release; distribution is unlimited. The Armenian Armed Forces is moving from a conscript force to a volunteer force. They are based on a soviet-era military structure, but are attempting to adopt a Western-style of force structure, similar to the U.S. and U.K. A key element in this is the establishment of a professional NCO corps within the Armenian Army. As they seek to develop the senior enlisted ranks, as well as move to an all-volunteer force, they have identified t...

  4. Suicide prevention in the US armed forces and implications for Chinese armed forces%透视美军自杀防控工作

    Institute of Scientific and Technical Information of China (English)

    于双平; 杨征; 毛军文

    2012-01-01

    过去10年间,尤其是阿富汗和伊拉克战争爆发以来,美军的自杀问题日益突出,其自杀率呈持续上升趋势,为此,美国国防部和各军种采取了一系列自杀防控措施,取得了一定效果.本文对美军自杀问题现状、采取的防控措施及面临的主要挑战进行了分析,并对中国军队做好相关工作提出了若干启示.%Suicide is one of the leading causes of death in the US armed forces in the past decade, especially after increased deployments as a result of Operation Enduring Freedom in Afghanistan and Operation Iraqi Freedom in Iraq. The US Department of Defense and its four services have done a lot to fight against suicide. Suicide prevention in the US armed forces is briefly reviewed based on the current information and its implications for Chinese armed forces are also summarized.

  5. Research in Radiobiology

    International Nuclear Information System (INIS)

    This document contains the tables of contents for the reports published by the University of Utah Radiobiology Laboratory from 1953--1987. Also included is a keyword index for the reports, and references for all books, book and symposia chapters and journal article published by Laboratory staff between 1950 and 1988

  6. With the Radiobiology Group

    CERN Multimedia

    1980-01-01

    The Radiobiology Group carries out experiments to study the effect of radiation on living cells. The photo shows the apparatus for growing broad beans which have been irradiated by 250 GeV protons. The roots are immersed in a tank of running water (CERN Weekly Bulletin 26 January 1981 and Annual Report 1980 p. 160). Karen Panman, Marilena Streit-Bianchi, Roger Paris.

  7. Treating self-injury: water mist spray versus facial screening or forced arm exercise.

    OpenAIRE

    N.N. Singh; Watson, J. E.; Winton, A S

    1986-01-01

    In three experiments, the effect of water mist spray on self-injurious and collateral behaviors was compared with either facial screening or forced arm exercise. Water mist spray was as effective as facial screening in suppressing face-slapping in Experiment 1. However, it was not as effective as facial screening for self-injurious finger-licking in Experiment 2 or forced arm exercise for excessive ear-rubbing in Experiment 3. These results suggest that while water mist spray is effective, it...

  8. The Use of Armed Force, Weapons of Mass Destruction and the UN

    Directory of Open Access Journals (Sweden)

    Hans Blix

    2006-06-01

    Full Text Available At the present time we do not see any risk of major powers using armed force against each other. The relations between the great powers are not exactly relaxed, but they are also not tense. All pursue the market economy of various shapes and shades as their economic model. All are bent on pragmatism. After the end of the Cold War European countries do not see Russia as a military threat and many states in Europe are reorienting their armed forces from defense of their own territory to use in international peacekeeping or peace-enforcing operations.

  9. [Application of robotic technology to the needs in the medical service of the Armed Forces].

    Science.gov (United States)

    Iudin, A B; Chepur, S V; shestakov, S V

    2013-06-01

    Application of robotic technology to the needs in the medical service of the Armed Forces. Further development of the medical service is inseparably associated with the implementation of robot technology into the practice of medical support of the Armed Forces of the Russian federation. For this purpose it is necessary to create a clinical scientific research centre of robot technology and interdepartmental scientific research simulation training center on the basis of the Kirov Military Medical Academy. It is also necessary to provide development of medical robotic complexes of tactical level of the medical service. PMID:24000639

  10. Collective Mission Simulation Capability for the Netherlands Armed Forces

    NARCIS (Netherlands)

    Lemmers, A.; Karelse, R.; Jacobs, L.R.M.A.; Klomp, J.

    2010-01-01

    Military forces all over the world are transforming to adapt to the changed world politics. The application of the latest technology is key in this transformation process. Examples of operational changes are more expeditionary operations, joint and combined operations, information data management, a

  11. A Comparison between Two Force-Position Controllers with Gravity Compensation Simulated on a Humanoid Arm

    OpenAIRE

    Giovanni Gerardo Muscolo; Kenji Hashimoto; Atsuo Takanishi; Paolo Dario

    2013-01-01

    The authors propose a comparison between two force-position controllers with gravity compensation simulated on the DEXTER bioinspired robotic arm. The two controllers are both constituted by an internal proportional-derivative (PD) closed-loop for the position control. The force control of the two systems is composed of an external proportional (P) closed-loop for one system (P system) and an external proportional-integrative (PI) closed-loop for the other system (PI system). The simulation t...

  12. Promoting Positive Emotional Health of Children of Transient Armed Forces Families

    Science.gov (United States)

    Eodanable, Miranda; Lauchlan, Fraser

    2012-01-01

    The focus of this research was to promote emotional health in a small primary school (n = 180), with a highly transient pupil population of armed forces children (Service children). Negative effects of pupil mobility have been found to relate to academic attainment (Dobson, Henthorne, & Lynas, 2000; Mott, 2002), but its effect on social and…

  13. Intuitive Decisionmaking: Tacit Knowing in Action by U.S. Armed Forces Officers in 2011

    Science.gov (United States)

    Moilanen, Jon H.

    2012-01-01

    This qualitative inquiry was a naturalistic exploration of participants' perception or understanding of their intuitive decisionmaking processes. A bounded case study explored how a purposeful sampling of U.S. Armed Forces officers--primarily U.S. Army officers--perceived or understood intuitive decisionmaking in the context of their…

  14. Postdeployment Battlemind Training for the U.K. Armed Forces: A Cluster Randomized Controlled Trial

    Science.gov (United States)

    Mulligan, Kathleen; Fear, Nicola T.; Jones, Norman; Alvarez, Helen; Hull, Lisa; Naumann, Ulrike; Wessely, Simon; Greenberg, Neil

    2012-01-01

    Objective: Combat exposure can increase the risk of subsequent psychological ill-health in armed forces (AF) personnel. A U.S. postdeployment psycho-educational intervention, Battlemind, showed a beneficial effect on mental health in U.S. military personnel exposed to high combat levels. We evaluated the effectiveness of an anglicized version of…

  15. Haptic perception of force magnitude and its relation to postural arm dynamics in 3D.

    Science.gov (United States)

    van Beek, Femke E; Bergmann Tiest, Wouter M; Mugge, Winfred; Kappers, Astrid M L

    2015-12-08

    In a previous study, we found the perception of force magnitude to be anisotropic in the horizontal plane. In the current study, we investigated this anisotropy in three dimensional space. In addition, we tested our previous hypothesis that the perceptual anisotropy was directly related to anisotropies in arm dynamics. In experiment 1, static force magnitude perception was studied using a free magnitude estimation paradigm. This experiment revealed a significant and consistent anisotropy in force magnitude perception, with forces exerted perpendicular to the line between hand and shoulder being perceived as 50% larger than forces exerted along this line. In experiment 2, postural arm dynamics were measured using stochastic position perturbations exerted by a haptic device and quantified through system identification. By fitting a mass-damper-spring model to the data, the stiffness, damping and inertia parameters could be characterized in all the directions in which perception was also measured. These results show that none of the arm dynamics parameters were oriented either exactly perpendicular or parallel to the perceptual anisotropy. This means that endpoint stiffness, damping or inertia alone cannot explain the consistent anisotropy in force magnitude perception.

  16. Department of Radiobiology - foreword

    International Nuclear Information System (INIS)

    The research program of the Department of Radiobiology of the Niewodniczanski Institute of Nuclear Physics is performed by two laboratories: 1/Laboratory of Neutron Therapy and Applied in Radiobiology Therapy and Agriculture. 2/ Laboratory of Radiation and Environmental Mutagenesis. The aim of the first mentioned Laboratory is to determine the Relative Biological Effectiveness (RBE) of fast 5.6 MeV neutrons with regard to regime of fractionation. Our goal is to reduce the number of fraction of neutron therapy what makes possible increasing the total dose. The second mentioned Laboratory engages in research on the mutagenesis in rape-seed in vitro regeneration of dihaploids and pollen grains. The object is to find how much fast neutrons, X and γ-rays irradiations stimulate the dihaploide production and to determine their reaction in flower buds microspores and anther cultures. (author)

  17. Suicide after leaving the UK armed forces--a cohort study.

    Directory of Open Access Journals (Sweden)

    Navneet Kapur

    2009-03-01

    Full Text Available BACKGROUND: Few studies have examined suicide risk in individuals once they have left the military. We aimed to investigate the rate, timing, and risk factors for suicide in all those who had left the UK Armed Forces (1996-2005. METHODS AND FINDINGS: We carried out a cohort study of ex-Armed Forces personnel by linking national databases of discharged personnel and suicide deaths (which included deaths receiving either a suicide or undetermined verdict. Comparisons were made with both general and serving populations. During the study period 233,803 individuals left the Armed Forces and 224 died by suicide. Although the overall rate of suicide was not greater than that in the general population, the risk of suicide in men aged 24 y and younger who had left the Armed Forces was approximately two to three times higher than the risk for the same age groups in the general and serving populations (age-specific rate ratios ranging from 170 to 290. The risk of suicide for men aged 30-49 y was lower than that in the general population. The risk was persistent but may have been at its highest in the first 2 y following discharge. The risk of suicide was greatest in males, those who had served in the Army, those with a short length of service, and those of lower rank. The rate of contact with specialist mental health was lowest in the age groups at greatest risk of suicide (14% for those aged under 20 y, 20% for those aged 20-24 y. CONCLUSIONS: Young men who leave the UK Armed Forces were at increased risk of suicide. This may reflect preservice vulnerabilities rather than factors related to service experiences or discharge. Preventive strategies might include practical and psychological preparation for discharge and encouraging appropriate help-seeking behaviour once individuals have left the services.

  18. 75 FR 4051 - Defense Health Board; DoD Task Force on the Prevention of Suicide by Members of the Armed Forces...

    Science.gov (United States)

    2010-01-26

    ... of the Secretary Defense Health Board; DoD Task Force on the Prevention of Suicide by Members of the...)(2) of Public Law, the DoD Task Force on the Prevention of Suicide by Members of the Armed Forces (hereafter, Task Force) will meet on February 11, 2010, to gather information pertaining to suicide...

  19. Kyrgyzstan’s Fragmented Police and Armed Forces

    Directory of Open Access Journals (Sweden)

    Erica Marat

    2011-03-01

    Full Text Available This article is a first attempt to analyze the underlying reasons behind the unprofessional behavior of the Kyrgyz military and police during ethnic conflict in Osh on June 10-14, 2010. It argues that the higher military leadership in Bishkek shares a common distrust of the Tashkent regime and overall uncertainly about power sharing two months after regime change, while lower level personnel may have provoked the Uzbek minority, because of their nationalist feelings (the majority of police and army personnel are ethnic Kyrgyz and overall frustration with the fragmented political leadership. The situation was further exacerbated by the lack of political control over the security forces and their lack of adequate training to deal with civic unrest.

  20. A Comparison between Two Force-Position Controllers with Gravity Compensation Simulated on a Humanoid Arm

    Directory of Open Access Journals (Sweden)

    Giovanni Gerardo Muscolo

    2013-01-01

    Full Text Available The authors propose a comparison between two force-position controllers with gravity compensation simulated on the DEXTER bioinspired robotic arm. The two controllers are both constituted by an internal proportional-derivative (PD closed-loop for the position control. The force control of the two systems is composed of an external proportional (P closed-loop for one system (P system and an external proportional-integrative (PI closed-loop for the other system (PI system. The simulation tests performed with the two systems on a planar representation of the DEXTER, an eight-DOF bioinspired arm, showed that by varying the stiffness of the environment, with a correct setting of parameters, both systems ensure the achievement of the desired force regime and with great precision the desired position. The two controllers do not have large differences in performance when interacting with a lower stiffness environment. In case of an environment with greater rigidity, the PI system is more stable. The subsequent implementation of these control systems on the DEXTER robotic bioinspired arm gives guidance on the design and control optimisation of the arms of the humanoid robot named SABIAN.

  1. Rehabilitation of a Human Arm Supported by a Robotic Manipulator: A Position/Force Cooperative Control

    Directory of Open Access Journals (Sweden)

    Haifa Mehdi

    2010-01-01

    Full Text Available Problem statement: The assistance of person with limited ability of arm movement is necessary for rehabilitation reasons. This aid is required not only to cover the human performances of the arm in motion and force but also to have a strictly stable dynamics. In this study, we proposed a cooperative system between a disabled arm and a robotic manipulator to reach such objectives. Desired positions and contact forces were imposed by the disabled human whereas appropriate torques were applied by the manipulator to follow human intension. Approach: Various control strategies were proposed during recent years to solve position/force control problem. The impedance control concept was used in this study. A relationship between the dynamics of the robot and its energy was developed to derive stability conditions of the robotic system at the constrained motion phase using a suitable Lyapunov approach. Results: New sufficient conditions of asymptotic stability were developed. To prove the efficiency of the proposed approach, a prototype of a human arm coupled to cooperative constrained robotic manipulator was used. The simulation results showed the stability and the performances of the proposed approach. Conclusion: Results showed the possibility of their use in a real context of rehabilitation of injured and disabled people.

  2. OPTIMIZATION OF FINANCIAL PERSONNEL NUMBER IN ARMED FORCES OF THE REPUBLIC OF BELARUS

    Directory of Open Access Journals (Sweden)

    A. V. Bolshakova

    2014-01-01

    Full Text Available The paper considers a problem pertaining to reduction of the Armed Forces of the Republic of Belarus and necessity to carry out economically reasonable reforms optimizing strength of financial personnel with the purpose to decrease its number but without undermining financial and operational activities of the Armed Forces as a whole. It has been proposed to optimize strength of financial personnel in the Armed Forces while executing organizational staff transformations such as introduction of a centralized accounting system for service personnel by an example of the Ministry of Defense of the Russian Federation.Normative for financial personnel strength of the supposed unified financial centre which is involved in accounting recordings on salary and other payments has been calculated on the basis of inter-branch standards. While taking as an example a conventional organization “B” with staff strength which is equal to the strength of the Armed Forces of the Republic of Belarus the possible efficiency in introduction of the centralized accounting system for service personnel has been determined in the paper. According to represented calculations reduction of financial personnel dealing with accounting recordings on salary and other payments in the whole organization “B” can constitute up to 60 persons with more than 200 branches which are carrying out independent payment accounting for personnel concerned.Dependence of strength normative on number of financial bodies, percentage of personnel receiving payments through a unified financial centre and concentration of financial and economic document circulation has been determined in the paper. It has been pointed out that it is not sufficient to determine quantitative indices in order to ensure an objective reflection of the efficiency of possible introduction of the centralized accounting system for service personnel in the Armed Forces. In order to obtain complete information it is

  3. The training value of working with armed forces inpatients in psychiatry.

    Science.gov (United States)

    de Burgh, H Thomas

    2016-04-01

    Over the last 10 years, the UK armed forces (UKAF) have been involved in operations worldwide. Mental health in the armed forces (AF) has been the subject of considerable interest in part because of a perceived added risk of psychological distress in this population. Inpatient psychiatric services are provided through partnerships with NHS hospitals. The Cavell Centre, Peterborough's acute inpatient psychiatric unit has up to four beds for service personnel, under the care of a civilian consultant psychiatrist and his AF Foundation Year 2 doctor (F2). This was the only Ministry of Defence (MoD) inpatient unit which had a training post for an AF doctor, but the post ended in August 2014 with the closure of MoD Hospital Unit Peterborough (MDHU(P)). This article outlines the differences in civilian and AF inpatient care and discusses the training value of AF doctors managing service personnel who are psychiatric inpatients.

  4. Automated processing of data on the use of motor vehicles in the Serbian Armed Forces

    Directory of Open Access Journals (Sweden)

    Nikola S. Osmokrović

    2012-10-01

    Full Text Available The main aim of introducing information technology into the armed forces is the automation of the management process. The management in movement and transport (M&T in our armed forces has been included in the process of automation from the beginning. For that reason, today we can speak about the automated processing of data on road traffic safety and on the use of motor vehicles. With regard to the overall development of the information system of the movement and transport service, the paper presents an information system of the M&T service for the processing of data on the use of motor vehicles. The main features, components and functions of the 'Vozila' application, which was specially developed for the automated processing of data on motor vehicle use, are explained in particular.

  5. [Medical research in the US Armed Forces (Report 3). The US Army].

    Science.gov (United States)

    Agapitov, A A; Aleĭnikov, S I; Bolekhan, V I; Ivchenko, I V; Krassiĭ, A B; Nagibovich, O A; Petrov, S V; Rezvantsev, M V; Soldatov, E A; Shalakhin, R A; Sheppli, E V

    2012-12-01

    The US Army. The present article is the third part of the review dedicated to organization and management of medical research in the US Armed Forces. The first and the second parts have been published in the previous issuses of the journal. Specifically this article is dedicated to organization and management of medical research in the US Army. It is shown that in the US Army the medical and biological research is conducted and coordinated by the special US Army Medical Research and Materiel Command. The following units are successively presented: US Army Institute of Surgical Research, US Army Medical Research Institute of Chemical Defense, US Army Medical Research Institute of Infectious Diseases, US Army Research Institute of Environmental Medicine, Walter Reed Army Institute of Research, US Army Aeromedical Research Laboratory, Armed Forces Institute of Regenerative Medicine. The particular research programs conducting in the above mentioned institutions are presented.

  6. The Revolutionary Armed Forces of Colombia (FARC) and the Development of Narco-Submarines

    OpenAIRE

    Michelle Jacome Jaramillo

    2016-01-01

    The Revolutionary Armed Forces of Colombia (FARC) have been one of the world's most consistently formidable violent non-state actors over the last forty years. Unsurprisingly, the group has provided one of the most compelling and concerning examples of the level of technical sophistication attainable by sub-state organizations. Over the last two decades the group has carried out an iterative and innovative process that, in reaction to improved detection capabilities, has brought them from dep...

  7. Project management in major systems acquisition for the Polish Armed Forces

    OpenAIRE

    Chyla, Wojciech L.

    2003-01-01

    This project investigates the potential role of project management policy in major systems acquisition for the Polish Armed Forces (PAF). It includes a short overview of program management in the United States Department of Defense (DoD); analysis of present procedures in the PAF; a cost and benefit discussion of implementing the policy in Poland; and finally, a discussion of possible solutions and implementation plans. The PAF have undergone major transformation since the fall of the Berlin'...

  8. AN EMPIRICAL SURVEY ON BASIC MILITARY TRAINING IN SLOVENIAN ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Maja GARB

    2014-04-01

    Full Text Available Before employment in the Slovenian Armed Forces, all candidates have to finish basic military training. The empirical survey, done in 2011 on a group of military candidates in a Slovenian Training Center, checked the motivation, level of skills and education, attitudes of leaders, military identity, prestige and social support of these candidates. The results confirmed the skills’ and fighters’ orientation of Slovenian soldiers, but surprised with the paleomodern motivators for military job.

  9. The impact of military identity on performance in the Norwegian Armed Forces

    OpenAIRE

    Johansen, Rino Bandlitz

    2013-01-01

    From a Norwegian point of view, doctrinaire guidance now set the premises for new perspectives related to the military ethos and identity. The exodus of idealism, a military identity based on traditional values as altruism, patriotism and nationalism, has opened up for professionalism as a preferred and necessary military identity in the Norwegian armed forces. Based on this paradigmatic change, it follows that if professionalism could be reliably defined and measured, it might...

  10. German Soldier and German Unity: Political Foundations of the German Armed Forces

    OpenAIRE

    Abenheim, Donald

    1991-01-01

    The unification of Germany has transformed the political-military landscape of central Europe. Not the least of the issues raised by the union of the Federal Republic and the German Democratic Republic is the fate of the professional soldier in a united Germany. The present study analyzes the concept of military professionalism in the setting of the two former German states, placing emphasis on the political-ethical foundations of the West German armed forces and the political mechanisms of t...

  11. Engagement of the Slovak Armed Forces in Future Crisis Management Operations

    OpenAIRE

    Peter PINDJÁK

    2014-01-01

    During the past two decades, the Armed Forces of the Slovak Republic (AF SR) have participated in more than thirty operations under major international organizations and coalitions. Despite the political interest to sustain active engagement of the AF SR in international crisis management operations, the declining level of capabilities coupled with the urgent need to modernize most of the military equipment compels the Slovak Ministry of Defense to commence a complex optimization process. Eve...

  12. Vibration transmissibility characteristics of the human hand-arm system under different postures, hand forces and excitation levels

    Science.gov (United States)

    Adewusi, S. A.; Rakheja, S.; Marcotte, P.; Boutin, J.

    2010-07-01

    Biodynamic responses of the hand-arm system have been mostly characterized in terms of driving-point force-motion relationships, which have also served as the primary basis for developing the mechanical-equivalent models. The knowledge of localized vibration responses of the hand-arm segments could help derive more effective biodynamic models. In this study, the transmission of z h-axis handle vibration to the wrist, elbow and the shoulder of the human hand and arm are characterized in the laboratory for the bent-arm and extended arm postures. The experiments involved six subjects grasping a handle subject to two different magnitudes of broad-band random vibration, and nine different combinations of hand grip and push forces. The vibration transmissibility data were acquired in the z h- and y h-axis at the wrist and shoulder, and along all the three axes around the elbow joint. The results show that the human hand-arm system in an extended arm posture amplifies the vibration transmitted to the upper-arm and the whole-body at frequencies below 25 Hz, but attenuates the vibration above 25 Hz more effectively than the bent-arm posture, except at the shoulder. The magnitudes of transmitted vibration under an extended arm posture along the y h-axis were observed to be nearly twice those for the bent-arm posture in the low frequency region. The results further showed that variations in the grip force mostly affect vibration transmissibility and characteristic frequencies of the forearm, while changes in the push force influenced the dynamic characteristics of the entire hand-arm system. The magnitudes of transmitted vibration in the vicinity of the characteristic frequencies were influenced by the handle vibration magnitude.

  13. Hereditary cerebellar ataxia progressively impairs force adaptation during goal-directed arm movements.

    Science.gov (United States)

    Maschke, Matthias; Gomez, Christopher M; Ebner, Timothy J; Konczak, Jürgen

    2004-01-01

    We investigated how humans with hereditary cerebellar degeneration [spinocerebellar ataxia (SCA) type 6 and 8, n = 9] and age- and sex-matched healthy controls (n = 9) adapted goal-directed arm movements to an unknown external force field. We tested whether learning could be generalized to untrained regions in the workspace, an aspect central to the idea of an internal model, and if any learning could be retained. After removal of the force field, SCA patients showed little or no learning-related aftereffects indicating that repeated force-field exposure never led to successful force compensation. In contrast, healthy control subjects quickly adapted their movements to the new force field. The difference in force adaptation was significant for movements to targets that required both the shoulder and elbow joint (P < 0.001). Moreover, the generalization of learned movements to targets outside the learned workspace was prevented by the cerebellar degeneration (P < 0.01). Retention of force adaptation was significantly lower in SCA patients (P = 0.003). The severity of ataxia in SCA patients correlated negatively with the extent of learning (r = -0.84, P = 0.004). Our findings imply that progressive loss of cerebellar function gradually impairs force adaptation. The failure to generalize learning suggests that cerebellar degeneration prevents the formation of an internal representation of the limb dynamics. PMID:13679403

  14. Forces and moments generated by the human arm: Variability and control

    Science.gov (United States)

    Xu, Y; Terekhov, AV; Latash, ML; Zatsiorsky, VM

    2012-01-01

    This is an exploratory study of the accurate endpoint force vector production by the human arm in isometric conditions. We formulated three common-sense hypotheses and falsified them in the experiment. The subjects (n=10) exerted static forces on the handle in eight directions in a horizontal plane for 25 seconds. The forces were of 4 magnitude levels (10 %, 20%, 30% and 40% of individual MVC). The torsion moment on the handle (grasp moment) was not specified in the instruction. The two force components and the grasp moment were recorded, and the shoulder, elbow, and wrist joint torques were computed. The following main facts were observed: (a) While the grasp moment was not prescribed by the instruction, it was always produced. The moment magnitude and direction depended on the instructed force magnitude and direction. (b) The within-trial angular variability of the exerted force vector (angular precision) did not depend on the target force magnitude (a small negative correlation was observed). (c) Across the target force directions, the variability of the exerted force magnitude and directional variability exhibited opposite trends: In the directions where the variability of force magnitude was maximal, the directional variability was minimal and vice versa. (d) The time profiles of joint torques in the trials were always positively correlated, even for the force directions where flexion torque was produced at one joint and extension torque was produced at the other joint. (e) The correlations between the grasp moment and the wrist torque were negative across the tasks and positive within the individual trials. (f) In static serial kinematic chains, the pattern of the joint torques distribution could not be explained by an optimization cost function additive with respect to the torques. Plans for several future experiments have been suggested. PMID:23080084

  15. Between history, amnesia and selective memory: The South African armed forces, a century’s perspective

    Directory of Open Access Journals (Sweden)

    Ian Van der Waag

    2013-02-01

    Full Text Available 2012 has a double significance for this year sees the centenary of the founding of the African National Congress (8 January and of the creation of the Union Defence Forces (1 July, two organisations that have for much of the twentieth century shared a contested history. Yet, in a remarkable bouleversement, South Africa has come through this difficult past and, over the past two decades, a new South African society has been recreated following an interesting period of adjustment following the end of the Cold War and the growth of democracy in the developing world. These changes have necessarily affected her armed forces and the roles defined for them. Some commentators, particularly in the years immediately following 1994, asserted that military power had lost all of its vaunted, Cold-War importance in a new postmodern environment. Others still, recognising future challenges, argued that South Africa, beset with far-reaching socio-economic crises, could no longer afford the burden of military forces. Most scholars agree now that these perspectives were short-sighted and that, while the risk of major conflict has receded, the events of 9/11, and its consequences, demonstrate that the continental and international landscapes are less certain, less stable and less predictable, than that for which many had hoped. Clearly, South African interests are intertwined inextricably in regional and global affairs and if she is to protect these interests and ensure her security, she must maintain credible military force capable of meeting an array of contingencies. It was with this in mind that the strategic arms deal, since the subject of much debate, was passed by parliament:[i] the promise of a full technological transformation, to accompany the human transformation, offered. [i] J Sylvester & A Seegers. “South Africa’s Strategic Arms Package: A Critical Analysis”. Scientia Militaria 36/1. 2008. 52-77.

  16. Radiation Protection Research: Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C

    2000-07-01

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality in nuclear workers in Belgium; to document the feasibility of retrospective cohort studies in Belgium; (2) to participate in the IARC study; (3) to elucidate the molecular basis of the effects of ionising radiation in the mammalian embryo during the early phases of its development; (4) to assess the genetic risk of maternal exposure to ionizing radiation; (5) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 1999 are reported.

  17. [The organizational bases for the building of a modern medical support system for the Armed Forces].

    Science.gov (United States)

    Chizh, I M

    1996-01-01

    In the article the problems concerning characteristic features of the local wars and armed conflicts, organization bases of construction of The Army and Fleet medical support modern system are discussed. The organization of personnel medical security is considered depending on the duration, intensity and spatial scope of military conflict, peculiarities of group (forces) application and ways of military actions conduction. The distribution of federal troops sanitary losses during the war in Chechenskaya Republic is shown depending on the type, localization and degree of injuries gravity as well as volume of the wounded and invalids evacuation by air transport and work of military medical institutions. The following principles of construction of the Armed Forces medical support system are formulated: The system must be in compliance with troops goals, structure, strategy and tactics, its specificity; development of medical security forms and methods, their historicism; interdependency, completeness and integrity of the system's elements; territorial aspects of its construction and management optimization. Considering character of the goals being laid on the Mobile Forces the paramount importance is attached to the level of readiness of medical service and its formations and units to act in crisis situations. PMID:8659162

  18. Motor adaptation to Coriolis force perturbations of reaching movements: endpoint but not trajectory adaptation transfers to the nonexposed arm

    Science.gov (United States)

    Dizio, P.; Lackner, J. R.

    1995-01-01

    1. Reaching movements made in a rotating room generate Coriolis forces that are directly proportional to the cross product of the room's angular velocity and the arm's linear velocity. Such Coriolis forces are inertial forces not involving mechanical contact with the arm. 2. We measured the trajectories of arm movements made in darkness to a visual target that was extinguished at the onset of each reach. Prerotation subjects pointed with both the right and left arms in alternating sets of eight movements. During rotation at 10 rpm, the subjects reached only with the right arm. Postrotation, the subjects pointed with the left and right arms, starting with the left, in alternating sets of eight movements. 3. The initial perrotary reaching movements of the right arm were highly deviated both in movement path and endpoint relative to the prerotation reaches of the right arm. With additional movements, subjects rapidly regained straight movement paths and accurate endpoints despite the absence of visual or tactile feedback about reaching accuracy. The initial postrotation reaches of the left arm followed straight paths to the wrong endpoint. The initial postrotation reaches of the right arm had paths with mirror image curvature to the initial perrotation reaches of the right arm but went to the correct endpoint. 4. These observations are inconsistent with current equilibrium point models of movement control. Such theories predict accurate reaches under our experimental conditions. Our observations further show independent implementation of movement and posture, as evidenced by transfer of endpoint adaptation to the nonexposed arm without transfer of path adaptation. Endpoint control may occur at a relatively central stage that represents general constraints such as gravitoinertial force background or egocentric direction relative to both arms, and control of path may occur at a more peripheral stage that represents moments of inertia and muscle dynamics unique to each

  19. NOVEL 6-DOF WEARABLE EXOSKELETON ARM WITH PNEUMATIC FORCE-FEEDBACK FOR BILATERAL TELEOPERATION

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiafan; FU Hailun; DONG Yiming; ZHANG Yu; YANG Canjun; CHEN Ying

    2008-01-01

    A particular emphasis is put on a novel wearable exoskeleton arm, ZJUESA, with 6 degrees of freedom, which is used for the robot teleoperation with the force-feedback in the unknown environment. In this external structure mechanism, the 3-revolution-prismatic-spherical (3RPS) parallel mechanism is devised from the concept of the human upper-limb anatomy and applied for the shoulder 3-DOF joint. Meanwhile, the orthogonal experiment design method is introduced for its optimal design. Aiming at enhancing the performance of teleoperation, the force feedback is employed by the pneumatic system on ZJUESA to produce the vivid feeling in addition to the soft control interface. Due to the compressibility and nonlinearity of the pneumatic force feedback system, a novel hybrid fuzzy controller for the precise force control is proposed and realized based on the Mega8 microcontroller units as the units of the distributed control system on ZJUESA. With the results of several experiments for master-slave control with force feedback, the feasibility of ZJUESA system and the effect of its hybrid fuzzy controller are verified.

  20. Sensor Prototype to Evaluate the Contact Force in Measuring with Coordinate Measuring Arms

    Directory of Open Access Journals (Sweden)

    Eduardo Cuesta

    2015-06-01

    Full Text Available This paper describes the design, development and evaluation tests of an integrated force sensor prototype for portable Coordinate Measuring Arms (CMAs or AACMMs. The development is based on the use of strain gauges located on the surface of the CMAs’ hard probe. The strain gauges as well as their cables and connectors have been protected with a custom case, made by Additive Manufacturing techniques (Polyjet 3D. The same method has been selected to manufacture an ergonomic handle that includes trigger mechanics and the electronic components required for synchronizing the trigger signal when probing occurs. The paper also describes the monitoring software that reads the signals in real time, the calibration procedure of the prototype and the validation tests oriented towards increasing knowledge of the forces employed in manual probing. Several experiments read and record the force in real time comparing different ways of probing (discontinuous and continuous contact and measuring different types of geometric features, from single planes to exterior cylinders, cones, or spheres, through interior features. The probing force is separated into two components allowing the influence of these strategies in probe deformation to be known. The final goal of this research is to improve the probing technique, for example by using an operator training programme, allowing extra-force peaks and bad contacts to be minimized or just to avoid bad measurements.

  1. The Armed Forces Research Institute of Medical Sciences: five decades of collaborative medical research.

    Science.gov (United States)

    Brown, Arthur; Nitayaphan, Sorachai

    2011-05-01

    The Armed Forces Research Institute of Medical Sciences (AFRIMS) is a 50-year-old joint institute of the US and Royal Thai Army Medical Departments located in Bangkok, Thailand. Investigators from the Institute have carried out research in Thailand and the region, in collaboration with many partners, focused on a large number of tropical infectious diseases. In celebration of the 50th anniversary, this paper summarizes highlights of this research, focusing on malaria, Japanese encephalitis, dengue, diarrhea and HIV. In addition, research done in support of the medical problems of refugees and of the health of Thai peace-keeping forces are summarized. The research carried out by AFRIMS and added to the scientific literature has contributed significantly to advancement in multiple areas of tropical infectious disease.

  2. Internally displaced "victims of armed conflict" in Colombia: the trajectory and trauma signature of forced migration.

    Science.gov (United States)

    Shultz, James M; Garfin, Dana Rose; Espinel, Zelde; Araya, Ricardo; Oquendo, Maria A; Wainberg, Milton L; Chaskel, Roberto; Gaviria, Silvia L; Ordóñez, Anna E; Espinola, Maria; Wilson, Fiona E; Muñoz García, Natalia; Gómez Ceballos, Angela Milena; Garcia-Barcena, Yanira; Verdeli, Helen; Neria, Yuval

    2014-10-01

    While conflict-induced forced migration is a global phenomenon, the situation in Colombia, South America, is distinctive. Colombia has ranked either first or second in the number of internally displaced persons for 10 years, a consequence of decades of armed conflict compounded by high prevalence of drug trafficking. The displacement trajectory for displaced persons in Colombia proceeds through a sequence of stages: (1) pre-expulsion threats and vulnerability, (2) expulsion, (3) migration, (4) initial adaptation to relocation, (5) protracted resettlement (the end point for most forced migrants), and, rarely, (6) return to the community of origin. Trauma signature analysis, an evidence-based method that elucidates the physical and psychological consequences associated with exposures to harm and loss during disasters and complex emergencies, was used to identify the psychological risk factors and potentially traumatic events experienced by conflict-displaced persons in Colombia, stratified across the phases of displacement. Trauma and loss are experienced differentially throughout the pathway of displacement.

  3. Influence of Reynolds number and forcing type in a turbulent von K\\'arm\\'an flow

    CERN Document Server

    Saint-Michel, Brice; Marié, Louis; Ravelet, Florent; Daviaud, François

    2014-01-01

    We present a detailed study of of a global bifurcation occuring in a turbulent von K\\'arm\\'an swirling flow. In this system, the statistically steady states progressively display hysteretic behaviour when the Reynolds number is increased above the transition to turbulence. We examine in detail this hysteresis using asymmetric forcing conditions --- rotating the impellers at different speeds. For very high Reynolds numbers, we study the sensitivity of the hysteresis cycle --- using complementary Particle Image Velocimetry (PIV) and global mechanical measurements --- to the forcing nature, imposing either the torque or the speed of the impellers. New mean states, displaying multiple quasi-steady states and negative differential responses, are experimentally observed in torque control. A simple analogy with electrical circuits is performed to understand the link between multi-stability and negative responses. The system is compared to other, similar "bulk" systems, to understand some relevant ingredients of nega...

  4. Satellite vehicle tracking aiming to increase traffic safety within the Serbian Armed Forces

    Directory of Open Access Journals (Sweden)

    Igor S. Milanović

    2012-10-01

    Full Text Available The purpose of this work is to show how to affect the most important factor of traffic safety - an individual, by using some technical solutions of satellite tracking of vehicles. By using units of the Land Forces as an example, a brief analysis of traffic safety for vehicles less than 5 years old has been performed. It is noticed that the number of traffic accidents with these vehicles involved has increased, so we tried to use one software package commercially available in order to show all advantages and disadvantages which could be noticed during this kind of vehicle tracking. The conclusion is that preventive vehicle tracking can improve traffic safety, but that a techno-economic analysis has to be done as well, in order to create all the necessary conditions for the introduction of this system in the units of the Serbian Armed Forces.

  5. Radiobiology and Epidemiology

    International Nuclear Information System (INIS)

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality in nuclear workers in Belgium and to co-ordinate the Belgian contribution to the 'International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry'; (2) to elucidate the molecular basis of individual susceptibility to ionizing radiation in mammalian embryo during the early phases of its development; (3) to assess the genetic risk of maternal exposure to ionizing radiation; (4) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (5) to monitor the early variations of gene expression induced by ionising radiation and cytokines; (6) to evaluate the use of cytokines and natural substances for improving radiotherapy protocols; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 2000 are reported

  6. Radiobiology and Epidemiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C; Holmstock, L

    2001-04-01

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality in nuclear workers in Belgium and to co-ordinate the Belgian contribution to the 'International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry'; (2) to elucidate the molecular basis of individual susceptibility to ionizing radiation in mammalian embryo during the early phases of its development; (3) to assess the genetic risk of maternal exposure to ionizing radiation; (4) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (5) to monitor the early variations of gene expression induced by ionising radiation and cytokines; (6) to evaluate the use of cytokines and natural substances for improving radiotherapy protocols; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 2000 are reported.

  7. Etiology and pattern of maxillofacial injuries in the armed forces of pakistan

    International Nuclear Information System (INIS)

    To determine the etiology and pattern of maxillofacial injuries in the Armed Forces of Pakistan in terms of anatomical distribution of injuries. Three hundred consecutive patients of Armed Forces of Pakistan with maxillofacial injuries reporting to AFID and admitted to the hospital or treated as out-patients in the oral surgery clinic, were included in this study. Isolated nasal bone and frontal sinus fractures were excluded from the study. Anatomical distribution, frequency and etiology of fractures, rank at job and occupational as well as personal hobbies were recorded. Descriptive analyses were used to determine mean, standard deviation, percentage and range values. The most frequent bone fractured was the mandible, which accounted for 159 cases (53%). The zygomatic complex was fractured in 51 cases (17%), the maxilla in 12 cases (4 %), and the alveolar process in 21 cases (7%). The most common cause was road traffic accident (168 cases; 56%), followed by accidental fall (69 cases; 23%), gunshot injuries (27 cases; 9%), sports related injuries (15 cases; 5%), and injury associated with a fight (12 cases; 4%); there were only 9 cases of animals related injuries (3%). In this series, mandible was the most commonly fractured facial bone, while road traffic accident was the most common etiological factor. Results could be influenced by the personal and working environment. (author)

  8. Conducting qualitative research in the British Armed Forces: theoretical, analytical and ethical implications.

    Science.gov (United States)

    Finnegan, Alan

    2014-06-01

    The aim of qualitative research is to produce empirical evidence with data collected through means such as interviews and observation. Qualitative research encourages diversity in the way of thinking and the methods used. Good studies produce a richness of data to provide new knowledge or address extant problems. However, qualitative research resulting in peer review publications within the Defence Medical Services (DMS) is a rarity. This article aims to help redress this balance by offering direction regarding qualitative research in the DMS with a focus on choosing a theoretical framework, analysing the data and ethical approval. Qualitative researchers need an understanding of the paradigms and theories that underpin methodological frameworks, and this article includes an overview of common theories in phenomenology, ethnography and grounded theory, and their application within the military. It explains qualitative coding: the process used to analyse data and shape the analytical framework. A popular four phase approach with examples from an operational nursing research study is presented. Finally, it tackles the issue of ethical approval for qualitative studies and offers direction regarding the research proposal and participant consent. The few qualitative research studies undertaken in the DMS have offered innovative insights into defence healthcare providing information to inform and change educational programmes and clinical practice. This article provides an extra resource for clinicians to encourage studies that will improve the operational capability of the British Armed Forces. It is anticipated that these guidelines are transferable to research in other Armed Forces and the military Veterans population.

  9. Adaptive gravity and joint stiffness compensation methods for force-controlled arm supports

    NARCIS (Netherlands)

    Lobo-Prat, Joan; Keemink, Arvid Q.L.; Koopman, Bart F.J.M.; Stienen, Arno H.A.; Veltink, Peter H.

    2015-01-01

    People with muscular weakness can benefit from arm supports that compensate the weight of their arms. Due to the disuse of the arms, passive joint stiffness increases and providing only gravity compensation becomes insufficient to support the arm function. Hence, joint stiffness compensation is also

  10. A comparative study of the active force control schemes applied to robot arm

    International Nuclear Information System (INIS)

    In this paper, a comparative study of three different types of active force control (AFC) schemes applied to a robotic arm is described. The study particularly focuses on the techniques to compute the estimated inertia matrix (ΙΝ) of a robotic manipulator necessary for the execution of the AFC strategy since the computation of (ΙΝ) is the common central theme to all AFC-based schemes. The first of the three AFC schemes is based on the conventional method of obtaining (ΙΝ), the second uses artificial neural network while the third incorporates an iterative learning algorithm. The study also discusses the characteristics of the (ΙΝ) curves obtained, the trajectory track performance of the schemes and the effects of the modelled disturbances. The robustness of all the AFC schemes are also ascertained in the study. (Author)

  11. Sexually transmitted infections, active component, U.S. Armed Forces, 2000-2012.

    Science.gov (United States)

    2013-02-01

    This report summarizes incidence rates of the five most commonly diagnosed sexually transmitted infections (STIs) among active component service members of the U.S. Armed Forces during 2000 to 2012. Human papillomavirus (HPV) infections were the most common, followed in decreasing order of frequency by infections associated with chlamydia, herpes simplex virus, gonorrhea, and syphilis. Compared to their counterparts, women, younger service members, soldiers, and enlisted members had higher incidence rates of each STI. Rates tended to be lower among married personnel. Rates of chlamydia, HPV, and gonorrhea diagnoses were notably higher among women during 2006 to 2008 but rates of the latter two infections have since declined sharply. The relatively recent introduction of STI screening among young service women and the HPV vaccine are discussed.

  12. [Modern problems and main ways of imorovement of disinfecting art in Armed Forces].

    Science.gov (United States)

    Ivanov, A A; Musaev, A A; Komissarov, N V; Seleznev, A B; Loshakov, O V

    2016-02-01

    The article states the reasons defining the high relevance and significance of disinfection measures in modern conditions, reports general and specific problems of ensuring disinfection during medical service day-to-day activities. The directions of development of chemical and technical disinfectants and methods for'their use on different objects and under various climatic conditions are determined. It was shown that the crucial condition for implementation of theoretical and practical ways of improving disinfection affairs is a comprehensive approach based on concerted efforts of all authorities of Russian Armed Forces Medical Services, research and sanitary-epidemiological institutions, as well as relevant chars of the Military Medical Academy in close cooperation with representatives of domestic industry. PMID:27263206

  13. IMPLEMENTATION OF RISK MANAGEMENT IN THE ARMED FORCES OF THE SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Lubomír BELAN

    2015-10-01

    Full Text Available The risk management process represents the systematic application of management policies, procedures and experience focused on the activities of communication, consultation on how to create the appropriate context and on the identification, analysis, evaluation, handling, monitoring, and review of risks. Its content is represented by general principles, communication and counseling, creating links, risk assessment, monitoring and review of risks, handling and record of the process of risk management. In terms of The Armed Forces of the SR (OS SR, this issue is an important part of management in terms of proper functionality of the components, services, and facilities (qualifications. It is certainly the difficulty and danger incurred by the processes carried out in these organizational structures (e.g. shooting, weapon handling and training, etc. that provides a clear answer on what is necessary to do for a successful implementation of risk management issues.

  14. CHARACTERISTICS OF PRIMARY HEALTH CARE UTILIZATION OF MILITARY STAFF AND THEIR FAMILIES IN TURKISH ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Ozlem Ozkan

    Full Text Available Aim: The study was conducted to define characteristics of primary health care utilization of military staff and their families in Turkish Army Forces. Material-Method: A cross-sectional survey method was used. This study has carried out in 10 primary health care institutions in Ankara Military Zone which is tied to Turkish Armed Forces Land Forces Commandership in 1998. The data have been obtained from the application reasons of Turkish Armed Forces’ (TAF staff members and their families to main medical units and the results got after they have applied to those units and the physician’s intervention that have been written down on a form prepared by the researcher for a period of three months (January –March 1998. The data got from practices have been assessed by percentage Results:TAF’sstaff members commissioned in the detachment (4.0 and their families in dispensaries (8.7 have major application rate. While sergeants/corporals-privates in the detachment infirmary, and TSK staff members and their families in dispensaries have mostly applied to primary health care units for complaints (68.5%, 76.9%, 72.8%, the staff members working at the quatrain infirmary and their families have mostly applied to main medical units for the purpose of prescribing a medicine (59.8%, 90%. The most frequent diseases seen in military staff and their families in TAF are; diagnosed acute respiratory system infections, ankilosis acquired bone and muscle disorders, gastritis-duedonititis-ulcer, influenza, enteritis and diseases connected with diarrhoea, tonsillitis, parazitis-other infection diseases and bronchitis. Conclusion suggestions: These diseases are acute, preventable, high contagious diseases and the problems that occur related to these diseases could be eliminated within full-equipped primary health care services. Moreover, among the proposals of the research are the appointment of registered nurses to units health care to act as a public health nurses

  15. Microirradiation techniques in radiobiological research

    Indian Academy of Sciences (India)

    Guido A Drexler; Miguel J Ruiz-Gómez

    2015-09-01

    The aim of this work is to review the uses of laser microirradiation and ion microbeam techniques within the scope of radiobiological research. Laser microirradiation techniques can be used for many different purposes. In a specific condition, through the use of pulsed lasers, cell lysis can be produced for subsequent separation of different analytes. Microsurgery allows for the identification and isolation of tissue sections, single cells and subcellular components, using different types of lasers. The generation of different types of DNA damage, via this type of microirradiation, allows for the investigation of DNA dynamics. Ion microbeams are important tools in radiobiological research. There are only a limited number of facilities worldwide where radiobiological experiments can be performed. In the beginning, research was mostly focused on the bystander effect. Nowadays, with more sophisticated molecular and cellular biological techniques, ion microirradiation is used to unravel molecular processes in the field of radiobiology. These include DNA repair protein kinetics or chromatin modifications at the site of DNA damage. With the increasing relevance of charged particles in tumour therapy and new concepts on how to generate them, ion microbeam facilities are able to address unresolved questions concerning particle tumour therapy.

  16. A numerical investigation of flow around octopus-like arms: near-wake vortex patterns and force development.

    Science.gov (United States)

    Kazakidi, A; Vavourakis, V; Tsakiris, D P; Ekaterinaris, J A

    2015-01-01

    The fluid dynamics of cephalopods has so far received little attention in the literature, due to their complexity in structure and locomotion. The flow around octopuses, in particular, can be complicated due to their agile and dexterous arms, which frequently display some of the most diverse mechanisms of motion. The study of this flow amounts to a specific instance of the hydrodynamics problem for rough tapered cylinder geometries. The outstanding manipulative and locomotor skills of octopuses could inspire the development of advanced robotic arms, able to operate in fluid environments. Our primary aim was to study the hydrodynamic characteristics of such bio-inspired robotic models and to derive the hydrodynamic force coefficients as a concise description of the vortical flow effects. Utilizing computational fluid dynamic methods, the coefficients were computed on realistic morphologies of octopus-like arm models undergoing prescribed solid-body movements; such motions occur in nature for short durations in time, e.g. during reaching movements and exploratory behaviors. Numerical simulations were performed on translating, impulsively rotating, and maneuvering arms, around which the flow field structures were investigated. The results reveal in detail the generation of complex vortical flow structures around the moving arms. Hydrodynamic forces acting on a translating arm depend on the angle of incidence; forces generated during impulsive rotations of the arms are independent of their exact morphology and the angle of rotation; periodic motions based on a slow recovery and a fast power stroke are able to produce considerable propulsive thrust while harmonic motions are not. Parts of these results have been employed in bio-inspired models of underwater robotic mechanisms. This investigation may further assist elucidating the hydrodynamics underlying aspects of octopus locomotion and exploratory behaviors.

  17. A DIVERSE SOCIETY, A REPRESENTATIVE MILITARY? THE COMPLEXITY OF MANAGING DIVERSITY IN THE SOUTH AFRICAN ARMED FORCES

    OpenAIRE

    Lindy Heinecken

    2011-01-01

    After providing a brief background as to why issues of diversity managementwithin armed forces have become important internationally, this article outlines thediversity challenges facing the South African National Defence Force (SANDF).The first part of the article describes how the racial, language/ethnic and genderprofile of the SANDF has changed since 1994 and the tensions this has evoked. Thesecond part provides a brief conceptual framework against which diversitymanagement in the SANDF c...

  18. On the improvement of the control force readiness of students engaged arm sport

    Directory of Open Access Journals (Sweden)

    Voronkov A.V.

    2014-03-01

    Full Text Available Purpose: to identify the most informative tests and test exercises to assess force readiness athletes. Material : the study involved 23 students of mass sports categories. Ascertaining experiment involved testing athletes force readiness, analysis of their competitive activity and determination of strength and reliability of correlation tests with the results of the competition. There were 19 trials and two anthropometric measurements. Results : it was found that traditional tests to determine the strength abilities athletes enough authentic. A significant positive correlation with the results of competitive activity indicators carpal dynamometry (in two different weight classes, and on both hands in the categories of more than 85 kg. And pull-ups on the maximum number of times. A high degree of correlation between the results of competitive activity and holding a dumbbell on a special bench capture below. This exercise is effective for assessing the level of preparedness of special strength in the weight category up to 80 kg and 85 kg. Conclusions : the most informative tests and benchmarks to determine the exercise of power readiness 1-2 athletes in sports categories arm sport.

  19. Internally displaced "victims of armed conflict" in Colombia: the trajectory and trauma signature of forced migration.

    Science.gov (United States)

    Shultz, James M; Garfin, Dana Rose; Espinel, Zelde; Araya, Ricardo; Oquendo, Maria A; Wainberg, Milton L; Chaskel, Roberto; Gaviria, Silvia L; Ordóñez, Anna E; Espinola, Maria; Wilson, Fiona E; Muñoz García, Natalia; Gómez Ceballos, Angela Milena; Garcia-Barcena, Yanira; Verdeli, Helen; Neria, Yuval

    2014-10-01

    While conflict-induced forced migration is a global phenomenon, the situation in Colombia, South America, is distinctive. Colombia has ranked either first or second in the number of internally displaced persons for 10 years, a consequence of decades of armed conflict compounded by high prevalence of drug trafficking. The displacement trajectory for displaced persons in Colombia proceeds through a sequence of stages: (1) pre-expulsion threats and vulnerability, (2) expulsion, (3) migration, (4) initial adaptation to relocation, (5) protracted resettlement (the end point for most forced migrants), and, rarely, (6) return to the community of origin. Trauma signature analysis, an evidence-based method that elucidates the physical and psychological consequences associated with exposures to harm and loss during disasters and complex emergencies, was used to identify the psychological risk factors and potentially traumatic events experienced by conflict-displaced persons in Colombia, stratified across the phases of displacement. Trauma and loss are experienced differentially throughout the pathway of displacement. PMID:25135775

  20. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Remuneration of members of the Armed Forces of... COLLECTION OF INCOME TAX AT SOURCE Collection of Income Tax at Source § 31.3401(a)(1)-1 Remuneration of... as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  1. Visual feedback of the moving arm allows complete adaptation of pointing movements to centrifugal and Coriolis forces in human subjects.

    Science.gov (United States)

    Bourdin, C; Gauthier, G; Blouin, J; Vercher, J L

    2001-03-23

    A classical visuo-manual adaptation protocol carried out on a rotating platform was used to test the ability of subjects to adapt to centrifugal and Coriolis forces when visual feedback of the arm is manipulated. Three main results emerge: (a) an early modification of the initial trajectory of the movements takes place even without visual feedback of the arm; (b) despite the change in the initial trajectory, the new external force decreases the accuracy of the pointing movements when vision is precluded; (c) a visual adaptive phase allows complete adaptation of the pointing movements performed in a modified gravitoinertial field. Therefore vision would be essential for subjects to completely adapt to centrifugal and Coriolis forces. However, other sensory signals (i.e. vestibular and proprioceptive) may constitute the basis for early but partial correction of the pointing movements.

  2. The DOE Atmospheric Radiation Measurement Program's LES ARM Symbiotic Simulation and Observation (LASSO) Workflow: Initialization, Forcing and Multiscale Data Assimilation

    Science.gov (United States)

    Li, Z.; Cheng, X.; Gustafson, W. I., Jr.; Xiao, H.; Endo, S.; Vogelmann, A. M.; Toto, T.

    2015-12-01

    The Department of Energy Atmospheric Radiation Measurement (ARM) Program is developing a routine large-eddy simulation (LES) modeling framework at the ARM Climate Research Facility sites, known as the "LES ARM Symbiotic Simulation and Observation" (LASSO) Workflow. The routine simulations will be assessed using comprehensive ARM observations of the atmosphere and land-surface states, particularly cloud observations. Since small changes in thermodynamic profiles can manifest large changes in cloud properties, successful simulations require careful initialization, appropriate forcing, and possibly suitable lateral boundary conditions. We use a multiscale data assimilation (MS-DA) system as a major methodology for producing forcing datasets required by the LES modeling. The MS-DA will be implemented in the regional Weather Research and Forecasting (WRF) model at a cloud resolving resolution (~1 km). MS-DA leverages existing reanalyses (e.g., the NCEP North American Regional Reanalysis, NARR) and operational forecasting products (e.g. the North American Mesoscale Forecast System, NAM; the High-Resolution Rapid Refresh, HRRR) products, and takes advantage of ARM observations to directly constrain the spectra of horizontal scales down to a few km. The analysis from the MS-DA allows deriving initial conditions and forcing datasets for a range of spatial and temporal scales, developing hydrometeor forcing, exploring time-varying boundary conditions, and diagnosing other needed thermodynamic variables. It is stressed that the datasets from the MS-DA are integrated with datasets from other sources to form ensembles to account for uncertainties. The methodologies, implementation and evaluations are presented.

  3. Radiobiology software for educational purpose

    International Nuclear Information System (INIS)

    To understand radio-nuclide therapy and the basis of radiation protection, it is essential to understand radiobiology. With limited time for classroom teaching and limited time and resources for radiobiology experiments students do not acquire firm grasp of theoretical mathematical models and experimental knowledge of target theory and Linear quadratic models that explain nature of cell survival curves. We believe that this issue might be addressed with numerical simulation of cell survival curves using mathematical models. Existing classroom teaching can be reoriented to understand the subject using the concept of modeling, simulation and virtual experiments. After completion of the lecture, students can practice with simulation tool at their convenient time. In this study we have developed software that can help the students to acquire firm grasp of theoretical and experimental radiobiology. The software was developed using FreeMat ver 4.0, open source software. Target theory, linear quadratic model, cell killing based on Poisson model have been included. The implementation of the program structure was to display the menu for the user choice to be made and then program flows depending on the users choice. The program executes by typing 'Radiobiology' on the command line interface. Students can investigate the effect of radiation dose on cell, interactively. They can practice to draw the cell survival curve based on the input and output data and they can also compare their handmade graphs with automatically generated graphs by the program. This software is in the early stage of development and will evolve on user feedback. We feel this simulation software will be quite useful for students entering in the nuclear medicine, radiology and radiotherapy disciplines. (author)

  4. Clinical application of ocular trauma score for mechanical ocular injury in armed forces

    Directory of Open Access Journals (Sweden)

    Ying ZHANG

    2011-10-01

    Full Text Available Objective To evaluate the predictive value of ocular trauma score(OTS in mechanical ocular injuries occurring in military forces,and compare the difference of OTS application between ocular injury caused by military training and non-military training.Methods The data of 633 inpatients from armed forces suffering from injury of 665 eyes were retrospectively reviewed.Of the 665 injured eyes,326 were injured during military training and 339 during non-military training.The likelihood of final visual acuity(VA calculated with the OTS score was compared with that by the present OTS study,and the correlation between the score and final VA was then analyzed.Results Compared with the distribution of final VA in standard OTS score,the ratio in category 1 was statistically different in present study(P 0.05.There were significant differences in ratio of category 3 between eyes injured by military and non-military training(P < 0.05,and both ratios in category 1 were significantly different compared with those in standard OTS(P < 0.01,e.g.the ratio of NLP was lower(50% vs 73%,P < 0.01;43% vs 73%,P < 0.01;and the ratio in category 2 was significantly different between the eyes injured by non-military training and standard OTS(P < 0.05.However,the OTS showed positive correlation with final VA in present study(P < 0.0001.Conclusion OTS calculated at initial examination may primarily provide a piece of prognostic information of mechanical ocular injuries,and is of special benefit for deciding a prompt management or for evacuation decision for severe ocular injuries caused by military training.

  5. Frequency of coronary artery disease (cad) risk factors in armed forces

    International Nuclear Information System (INIS)

    To determine the frequency of risk factors of coronary artery disease (CAD) in apparently healthy soldiers of Pakistan Armed Forces. Study Design: Cross sectional descriptive study. Place and Duration of Study: Department of medicine, CMH Okara from July 2012 to Dec 2012. Patients and Methods: The study included 2215 male currently serving soldiers in age range of 18 to 52 years by consecutive sampling. Relevant history, body mass index (BMI), waist circumference (WC) and blood pressure (BP) of each subject were recorded. BMI > 25 kg/m/sup 2/ and WC > 90 cm was considered obesity and abdominal obesity respectively. BP > 140/90 mmHg was defined as hypertension. All the participants of study underwent blood glucose fasting, blood glucose random, ECG recording, personality assessment and lipid profile. Risk estimation was done using Eric Brittain scoring system. Results: In our study group 95.5% patients were having at least 1 risk factor of CAD, 54 % were having 2 to 4 risk factors while 3.93% had > 4 risk factors. Risk estimation of CAD using Eric Brittain scoring system showed that a large proportion of study group had high probability of developing ischemic heart disease in next 6 years. Conclusion: A large proportion of our soldiers are harboring risk of CAD due to increase in frequency of 8 conventional CAD risk factors especially obesity. (author)

  6. Mentoring from Afar: Nurse Mentor Challenges in the Canadian Armed Forces.

    Science.gov (United States)

    Neal, Laura D M

    2015-06-01

    There is an integral connection between leadership, mentoring and professional career progression within the nursing profession. The purpose of this article is to examine recommendations and best practices from the literature and provide a basis to construct a formalized successful mentoring dyad program with guidelines on establishing and maintaining a productive mentoring relationship over long distance. Canadian Armed Forces (CAF) nurses practice within a unique domain both domestically and abroad. The military environment incorporates many aspects of mentoring that could benefit significantly by distance interchange. Supported through examining literature within nursing, CAF publications and other professions along with contrasting successful distance mentoring programs, the findings suggest that a top-down, leadership-driven formal mentoring program could be beneficial to CAF nurses. The literature review outlines definitions of terms for mentorship and distance mentoring or e-mentoring. A cross section of technology is now embedded in all work environments with personal communication devices commonplace. Establishing mentoring relationships from afar is practical and feasible. This article provides a guided discussion for nursing leaders, managers and grassroots nurses to implement mentoring programs over distances. The recommendations and findings of this article could have universal applications to isolated nursing environments outside of Canadian military operational frameworks. PMID:26560257

  7. The Revolutionary Armed Forces of Colombia (FARC and the Development of Narco-Submarines

    Directory of Open Access Journals (Sweden)

    Michelle Jacome Jaramillo

    2016-03-01

    Full Text Available The Revolutionary Armed Forces of Colombia (FARC have been one of the world's most consistently formidable violent non-state actors over the last forty years. Unsurprisingly, the group has provided one of the most compelling and concerning examples of the level of technical sophistication attainable by sub-state organizations. Over the last two decades the group has carried out an iterative and innovative process that, in reaction to improved detection capabilities, has brought them from depending on disposable go-fast boats to transport drugs to possessing fully submersible and reusable covert vessels for transportation. The following case study will discuss the development of narco-submarines and the underlying motivations behind the pursuit of this complex engineering task. The case study will outline the different phases of the narco-submarine development and highlight FARC’s determination to overcome the challenges present in each design. This discussion will show how FARC’s systematized acquiring of information and expertise has resulted in the accomplishment of fully submersible vessels, capable of transporting more than 10 tons of illicit product.

  8. Irom Chanu Sharmila and the Movement against Armed Forces Special Powers Act (AFSPA

    Directory of Open Access Journals (Sweden)

    Aparajita Sharma

    2014-02-01

    Full Text Available This paper, through the narratives of activists and Meira Paibis reiterates the slogan—repeal the Armed Forces Special Powers Act (AFSPA, which is draconian and anti-people in spirit. The atroci- ty, which has been meted out on the people of Manipur because of this Act, is a profound viola- tion of human rights. Rape, mindless killings, kidnapping, fake encounters have been normalised by virtue of this Act. The youths have been badly affected due to the conflict emerging out of this Act which treats people in Manipur as ‘objects’ against the imagined boundaries of the Indian na- tion-state for security from the neighbouring nations. In this process, the lived experiences of the people have been pushed to the periphery against the massive motive of the state to protect bor- ders and the imagined nation, which is a direct offshoot of the legacy of colonialism in India. The paper has tried to capture the history of Manipur on a capsule to concretise the struggle of Irom Sharmila and the ‘hopes’ she gives to the people of Manipur for ‘peace’ and ‘justice’. Alongside, it makes a humble attempt to describe the ‘life’ of Irom Sharmila. In addition, it describes the rage of Manipuris, which have given rise to insurgency asking for ‘freedom’ through various platforms.

  9. Radiotherapy treatment planning linear-quadratic radiobiology

    CERN Document Server

    Chapman, J Donald

    2015-01-01

    Understand Quantitative Radiobiology from a Radiation Biophysics PerspectiveIn the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses.Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer TreatmentsThe book compil

  10. [Medical support of the Armed Forces of the Russian Federation: results of activity and tasks for 2016].

    Science.gov (United States)

    Fisun, A Ya

    2016-01-01

    The author gives an analysis of activity of the medical service of the Armed Forces in 2015 concerning development of normative legal basis for the military health care, improvement of the level of operational and mobilization readiness of subunits of army group, and military-medical institutions, improvement of effectiveness of treatment and evacuation measures, health resort treatment, medical stuff training optimization, sanitary-and-epidemiologic support, material and technical support improvement, adoption of advanced scientific achievements focusing on medical care delivery to army group, active development and increase in medical information systems, telehealth. system. The author gives data characterizing state and level of development of medical service of the Armed Forces and its dynamics. Main tasks and parameters of development of the service in 2016 and up to 2020 are formulated. PMID:27120950

  11. The Revolutionary Armed Forces of Colombia - People's Army (FARC-EP) Marxist-Leninist insurgency or criminal enterprise?

    OpenAIRE

    Saskiewicz, Paul E.

    2005-01-01

    Approved for public release; distribution is unlimited This thesis argues that the Revolutionary Armed Forces of Colombia- Peopleâ s Army (FARC-EP), Latin Americaâ s oldest and most powerful guerrilla organization, has not abandoned its ideological beliefs and devolved into a criminal enterprise as a result of its immersion in the drug trade and participation in other illicit activities. Rather, the movement remains an ideologically committed, guerrilla insurgency whose strategic objecti...

  12. The evolution of the curriculum of the Industrial College of the Armed Forces, 1924-1988 : a search for rigor

    OpenAIRE

    Gest, Robert

    1990-01-01

    This study examined the curriculum evolution process of the Industrial College of the Armed Forces (ICAF) and its predecessor, the Army Industrial College (AIC), as it was influenced by a variety of factors between the years 1924 and 1988. Most of the published material used for this study was found in the library of the National Defense University, Fort Lesley J. McNair, Washington, DC. Additionally, current and past College faculty and staff members were interviewed. ...

  13. The SLOWPOKE-2 nuclear reactor at the Royal Military College of Canada: applications for the Canadian Armed Forces

    International Nuclear Information System (INIS)

    The Royal Military College of Canada (RMCC) has a 20 kW SLOWPOKE-2 nuclear research reactor which is used for teaching and research.Since its commissioning, the reactor facility and instruments have been continuously upgraded to develop and enhance nuclear capabilities for the Canadian Armed Forces (CAF). Specific applications of neutron activation analysis (NAA), delayed neutron counting (DNC) and neutron imaging relevant to the CAF are discussed. (author)

  14. [Analysis of the use of field medical units in the armies of NATO and Russian Armed Forces].

    Science.gov (United States)

    Korniushko, I G; Iakovlev, S V; Murashev, I V; Sidorov, V A; Medvedev, V R; Matveev, A G

    2011-12-01

    An analysis of medical services of NATO and the Medical Service of the Armed Forces of the Russian Federation of modern technology deployment stages of medical evacuation (tents, inflatable structures, shelters, containers, medical armored vehicles, cars, etc.) is presented. Examples of their usage in isolated employment, usage in the group as a mobile medical stations and field hospitals in various conditions, the prospects and directions of development of technical means deployment of medical service are given.

  15. A New Crank Arm-Based Load Cell for the 3D Analysis of the Force Applied by a Cyclist

    Directory of Open Access Journals (Sweden)

    Alexandre Balbinot

    2014-12-01

    Full Text Available This report describes a new crank arm-based force platform designed to evaluate the three-dimensional force applied to the pedals by cyclists in real conditions. The force platform was designed to be fitted on a conventional competition bicycle crankset while data is transmitted wirelessly through a BluetoothTM module and also stored on a SD card. A 3D solid model is created in the SolidWorks (Dassault Systèmes SOLIDWORKS Corp. to analyze the static and dynamic characteristics of the crank arm by using the finite elements technique. Each crankset arm is used as a load cell based on strain gauges configured as three Wheatstone bridges. The signals are conditioned on a printed circuit board attached directly to the structure. The load cell showed a maximum nonlinearity error between 0.36% and 0.61% and a maximum uncertainty of 2.3% referred to the sensitivity of each channel. A roller trainer equipped with an optical encoder was also developed, allowing the measurement of the wheel’s instantaneous velocity.

  16. Risk factors of military training-related injuries in recruits of Chinese People's Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    王心; 汪培山; 周蔚

    2003-01-01

    Objective: To assess the incidence, types and risk factors of military training-related injuries in recruits of Chinese People's Armed Police Forces (CPAPF). Methods: A cohort study was made on the risk factors of injuries in 805 male recruits during the military training from December 25, 1999 toDecember 25, 2000. Results: A total of 111 recruits (14%) experienced one or more injuries, and the cumulative incidence was 16.1 injuries per 100 soldiers in a year. And 77.7% of the injuries belonged to overuse injuries of the skeletal and muscular systems, the most common type of which was stress fractures. Most injuries occurred in the 3rd month of training. Univariate analysis and logistic regression analysis of possible risk factors for overuse injuries were carried out, and a number of risk factors were identified: history of agricultural labor, history of lower limb injury, flatfoot and less running exercise before entry into the army. But a suitable body mass index (BMI) was a protective factor. Examination of age, body height, smoking, body flexibility and frequency of 2-mile running revealed no significant association with the injuries. Conclusions: History of agricultural labor, history of lower limb injury, flatfoot, less running exercise before entry into the army and lower BMI were risk factors of the overuse injuries. In order to decrease the incidence of overuse injuries, the young people with good physical ability and shapely body type should be selected during conscription. During the training, nutrition should be improved so as to decrease the incidence of injuries.

  17. [Risk factors for accidents during sports while serving in German armed forces].

    Science.gov (United States)

    Gundlach, N; Sammito, S; Böckelmann, I

    2012-03-01

    In the German Armed Forces sports activities should bring the benefits of good health and trained fitness which are the hallmarks of sportsmen. In order to achieve this aim it is important to avoid accidents which negate the benefit of sports. Until today there appear to be no studies in existence which demonstrate the risk factors of sports activities undertaken while in military service. Equivalent studies on civilian sport activities are scarcely comparable. To find out risk factors for accidents with any period of recovery we followed sports accidents while on duty in a German barracks with 4,300 soldiers over a two-year period. Additionally we asked about the time needed for recovery from each accident, parameters of lifestyle, the body mass index and the possibility of a nightshift before each accident. We examined a minimum of 410 accidents. We found associations between the accidents studied and particular risk factors, including doing sports more than two times a week, being active in a fitness or sports club, having the accident together with another sportsman and doing a nightshift before the day of the accident. Bad ground conditions contributed to a large number of accidents. A body mass index of 25 and higher had a significantly prolonged time for recovery. To avoid accidents, sport and ground conditions should be adapted to each other. In addition, overweight people are not only compromised for cardiovascular and neurological diseases but also have a higher risk of needing a prolonged time for recovery, thus it is important that overweight should be avoided and not only just be treated. PMID:22422284

  18. Quality of diabetes care at Armed Forces Hospital, Southern Region, Kingdom of Saudi Arabia, 2006

    Directory of Open Access Journals (Sweden)

    Ibrahim S Al-Arfaj

    2010-01-01

    Full Text Available Objective: The aim of this study was to assess the current status of care provided by the Diabetes Center at Armed Forces Hospital, Southern Region. Materials and Methods : A total of 260 patients were randomly selected from the diabetic patients attending the Diabetes Center. Study tools comprised patients′ data sheets and patients′ interview questionnaire. Results : Two-thirds of the patients were aged 50 years or more. Half of patients had had the disease for less than 10 years. Diet therapy alone was followed by 2.3% of diabetic patients. More than half of patients (56.5% were on insulin. Most of the diabetic patients were tested for HbA1c at least once per year (88.1%, and 71.5% had their lipid profile done at least once within two years. Low indicators included having a dilated eye examination (35.4%, assessment for nephropathy (28.8%, and having a well-documented foot examination (12.7%. Highest risk HbA1c level (>9.5% was reached by 38.8% of patients, 48.8% had a low-density lipoprotein level of <130 mg/dl, and 36.5% of patients had controlled blood pressure (≤130/80 mmHg. Most patients were satisfied with their interaction with the treating doctor, 41.5% were satisfied with access to treatment. Hypertension was found to be the most frequent comorbidity (38.5%. Conclusion : The quality of services as regard to process and outcome are low at the Diabetes Center. The overall diabetic patients′ satisfaction was high, whereas their satisfaction was low as regards to access to treatment or health professionals.

  19. Concept for a Predeployment Assessment of Basic Military Fitness in the German Armed Forces.

    Science.gov (United States)

    Rohde, Ulrich; Sievert, Alexander; Rüther, Thomas; Witzki, Alexander; Leyk, Dieter

    2015-11-01

    Military fitness is defined as a hierarchical 4-level construct in the German armed forces: (a) "Fundamental/Baseline Fitness," (b) "Basic Military Fitness," (c) "Task Fitness," and (d) "Mission Fitness." "Fundamental/Baseline Fitness" is assessed with the "Basic Fitness Test." However, this test alone is not sufficient to assess readiness for the physical demands of deployments. The first part of the article describes the development of a tool mirroring the specific physiological requirements of military operations on a joint forces level. The "Basic Military Fitness Tool" (BMFT) combines 4 crucial military demands into one single timed test run performed with field uniform (5 kg), body armor (13.4 kg), and helmet (1.6 kg): (a) maneuver under fire: 130 m run with changes in direction, velocity, and body position, (b) casualty rescue: 40 m of dragging a 50 kg load, (c) load carrying: 100 m carrying of two 18 kg loads, and (d) load lifting: lifting a 24 kg load on to a 1.25 m high rack 5 times. The second part covers the first assessment of BMFT selectivity between high- and low-performing groups. Muscle mass and strength are important factors for working with loads. Thus, female soldiers are expected to need more time to complete BMFT because of their on average lower muscle mass. Eighteen female (age = 28.5 ± 6.6 years, lean body mass [LBM] = 45.0 ± 4.5 kg; mean ± SD) and 104 male soldiers (age = 30.0 ± 8.4, LBM = 64.3 ± 7.1) completed isometric strength testing (hand grip = 344.3 ± 51.4 N and 547.3 ± 79.1 N, elbow flexors = 118.9 ± 16.9 and 235.1 ± 42.0, knee extensors = 433.2 ± 87.4 and 631.4 ± 111.4) and BMFT (259.2 ± 44.0 and 150.0 ± 21.1 s). Except age, all variables differed significantly (p < 0.01) between groups.

  20. Unsteady hydrodynamic forces acting on a robotic arm and its flow field: application to the crawl stroke.

    Science.gov (United States)

    Takagi, Hideki; Nakashima, Motomu; Ozaki, Takashi; Matsuuchi, Kazuo

    2014-04-11

    This study aims to clarify the mechanisms by which unsteady hydrodynamic forces act on the hand of a swimmer during a crawl stroke. Measurements were performed for a hand attached to a robotic arm with five degrees of freedom independently controlled by a computer. The computer was programmed so the hand and arm mimicked a human performing the stroke. We directly measured forces on the hand and pressure distributions around it at 200 Hz; flow fields underwater near the hand were obtained via 2D particle image velocimetry (PIV). The data revealed two mechanisms that generate unsteady forces during a crawl stroke. One is the unsteady lift force generated when hand movement changes direction during the stroke, leading to vortex shedding and bound vortex created around it. This bound vortex circulation results in a lift that contributes to the thrust. The other occurs when the hand moves linearly with a large angle of attack, creating a Kármán vortex street. This street alternatively sheds clockwise and counterclockwise vortices, resulting in a quasi-steady drag contributing to the thrust. We presume that professional swimmers benefit from both mechanisms. Further studies are necessary in which 3D flow fields are measured using a 3D PIV system and a human swimmer.

  1. The FORCE Fitness Profile--Adding a Measure of Health-Related Fitness to the Canadian Armed Forces Operational Fitness Evaluation.

    Science.gov (United States)

    Gagnon, Patrick; Spivock, Michael; Reilly, Tara; Mattie, Paige; Stockbrugger, Barry

    2015-11-01

    In 2013, the Canadian Armed Forces (CAF) implemented the Fitness for Operational Requirements of Canadian Armed Forces Employment (FORCE), a field expedient fitness test designed to predict the physical requirements of completing common military tasks. Given that attaining this minimal physical fitness standard may not represent a challenge to some personnel, a fitness incentive program was requested by the chain of command to recognize and reward fitness over and above the minimal standard. At the same time, it was determined that the CAF would benefit from a measure of general health-related fitness, in addition to this measure of operational fitness. The resulting incentive program structure is based on gender and 8 age categories. The results on the 4 elements of the FORCE evaluation were converted to a point scale from which normative scores were derived, where the median score corresponds to the bronze level, and silver, gold, and platinum correspond to a score which is 1, 2, and 3 SDs above this median, respectively. A suite of rewards including merit board point toward promotions and recognition on the uniform and material rewards was developed. A separate group rewards program was also tabled, to recognize achievements in fitness at the unit level. For general fitness, oxygen capacity was derived from FORCE evaluation results and combined with a measure of abdominal circumference. Fitness categories were determined based on relative risks of mortality and morbidity for each age and gender group. Pilot testing of this entire program was performed with 624 participants to assess participants' reactions to the enhanced test, and also to verify logistical aspects of the electronic data capture, calculation, and transfer system. The newly dubbed fitness profile program was subsequently approved by the senior leadership of the CAF and is scheduled to begin a phased implementation in June 2015. PMID:26506187

  2. The FORCE Fitness Profile--Adding a Measure of Health-Related Fitness to the Canadian Armed Forces Operational Fitness Evaluation.

    Science.gov (United States)

    Gagnon, Patrick; Spivock, Michael; Reilly, Tara; Mattie, Paige; Stockbrugger, Barry

    2015-11-01

    In 2013, the Canadian Armed Forces (CAF) implemented the Fitness for Operational Requirements of Canadian Armed Forces Employment (FORCE), a field expedient fitness test designed to predict the physical requirements of completing common military tasks. Given that attaining this minimal physical fitness standard may not represent a challenge to some personnel, a fitness incentive program was requested by the chain of command to recognize and reward fitness over and above the minimal standard. At the same time, it was determined that the CAF would benefit from a measure of general health-related fitness, in addition to this measure of operational fitness. The resulting incentive program structure is based on gender and 8 age categories. The results on the 4 elements of the FORCE evaluation were converted to a point scale from which normative scores were derived, where the median score corresponds to the bronze level, and silver, gold, and platinum correspond to a score which is 1, 2, and 3 SDs above this median, respectively. A suite of rewards including merit board point toward promotions and recognition on the uniform and material rewards was developed. A separate group rewards program was also tabled, to recognize achievements in fitness at the unit level. For general fitness, oxygen capacity was derived from FORCE evaluation results and combined with a measure of abdominal circumference. Fitness categories were determined based on relative risks of mortality and morbidity for each age and gender group. Pilot testing of this entire program was performed with 624 participants to assess participants' reactions to the enhanced test, and also to verify logistical aspects of the electronic data capture, calculation, and transfer system. The newly dubbed fitness profile program was subsequently approved by the senior leadership of the CAF and is scheduled to begin a phased implementation in June 2015.

  3. Active Force with Fuzzy Logic Control of a Two-Link Arm Driven by Pneumatic Artificial Muscles

    Institute of Scientific and Technical Information of China (English)

    H. Jahanabadi; M. Mailah; M. Z. Md Zain; H. M. Hooi

    2011-01-01

    In this paper,the practicality and feasibility of Active Force Control (AFC) integrated with Fuzzy Logic(AFCAFL) appliedto a two link planar arm actuated by a pair of Pneumatic Artificial Muscle (PAM) is investigated.The study emphasizes on the application and control of PAM actuators which may be considered as the new generation of actuators comprising fluidic muscle that has high-tension force,high power to weight ratio and high strength in spite of its drawbacks in the form of high nonlinearity behaviour,high hysteresis and time varying parameters.Fuzzy Logic (FL) is used as a technique to estimate the best value of the inertia matrix of robot arm essential for the AFC mechanism that is complemented with a conventional Proportional-Integral-Derivative (PID) control at the outermost loop.A simulation study was first performed followed by an experimental investigation for validation.The experimental study was based on the independent joint tracking control and coordinated motion control of the arm in Cartesian or task space.In the former,the PAM actuated arm is commanded to track the prescribed trajectories due to harmonic excitations at the joints for a given frequency,whereas for the latter,two sets of trajectories with different loadings were considered.A practical rig utilizing a Hardware-In-The-Loop Simulation (H1LS) configuration was developed and a number of experiments were carried out.The results of the experiment and the simulation works were in good agreement,which verified the effectiveness and robustness of the proposed AFCAFL scheme actuated by PAM.

  4. [Prospective planning of activity of the Medical service of the Armed Forces of the Russian Federation for 2016-2020].

    Science.gov (United States)

    Fisun, A Ya; Kalachev, O V; Redkin, E E; Bershev, M A; Murzo, A V

    2016-04-01

    The article reflects the characteristics of the Plan of activities of the Ministry of Defence of the Russian Federation for 2016-2020--an important long-term planning document of the Armed Forces. It stressed the need for synchronization of activities for chain of command and deadline. Presented structure of the Medical Service Plan Military District operations (fleet) military medical organization. The attention is focused on the content of its sections. For example, a military hospital layouts presented an action plan and a schedule of events. Reflecting the requirements of the Minister of Defense for the development and adjustment plans, indicators of their performance.

  5. Forced Conscription of Children during Armed Conflict: Experiences of Former Child Soldiers in Northern Uganda

    Science.gov (United States)

    Vindevogel, Sofie; Coppens, Kathleen; Derluyn, Ilse; De Schryver, Maarten; Loots, Gerrit; Broekaert, Eric

    2011-01-01

    Objective: Child soldiering can be considered as one of the worst practices of institutionalized child abuse. However, little is known about the scope and nature of this abuse and the consequent experiences of children enrolled in an armed faction. This research aims at enriching the knowledge on the experiences of child soldiers in the Lord's…

  6. 32 CFR Appendix A to Part 631 - Armed Forces Disciplinary Control Board Procedures Guide

    Science.gov (United States)

    2010-07-01

    ... members present, final action will be taken only on the business for which the meeting was called. c. A... addressing installation or command concerns or issues. (1) Federal, State, and local judicial, legislative... detrimental to the good order and discipline, health, morale, welfare, safety, and morals of Armed...

  7. Changes in force production and stroke parameters of trained able-bodied and unilateral arm-amputee female swimmers during a 30 s tethered front-crawl swim.

    Science.gov (United States)

    Lee, Casey Jane; Sanders, Ross H; Payton, Carl J

    2014-01-01

    This study examined changes in the propulsive force and stroke parameters of arm-amputee and able-bodied swimmers during tethered swimming. Eighteen well-trained female swimmers (nine unilateral arm amputees and nine able-bodied) were videotaped performing maximal-effort 30 s front-crawl swims, while attached to a load cell mounted on a pool wall. Tether force, stroke rate, stroke phase durations and inter-arm angle were quantified. The able-bodied group produced significantly higher mean and maximum tether forces than the amputee group. The mean of the intra-cyclic force peaks was very similar for both groups. Mean and maximum tether force had significant negative associations with 100 m swim time, for both groups. Both groups exhibited a similar fatigue index (relative decrease in tether force) during the test, but the amputees had a significantly greater stroke rate decline. A significant positive association between stroke rate decline and fatigue index was obtained for the able-bodied group only. Inter-arm angle and relative phase durations did not change significantly during the test for either group, except the recovery phase duration of the arm amputees, which decreased significantly. This study's results can contribute to the development of a more evidence-based classification system for swimmers with a disability.

  8. A DIVERSE SOCIETY, A REPRESENTATIVE MILITARY? THE COMPLEXITY OF MANAGING DIVERSITY IN THE SOUTH AFRICAN ARMED FORCES

    Directory of Open Access Journals (Sweden)

    Lindy Heinecken

    2011-08-01

    Full Text Available After providing a brief background as to why issues of diversity managementwithin armed forces have become important internationally, this article outlines thediversity challenges facing the South African National Defence Force (SANDF.The first part of the article describes how the racial, language/ethnic and genderprofile of the SANDF has changed since 1994 and the tensions this has evoked. Thesecond part provides a brief conceptual framework against which diversitymanagement in the SANDF can be interpreted, whereafter the various diversitymanagement programmes instituted over the years to cultivate a respect for diversityare outlined. It is argued that the predominant emphasis on ‘workplace diversity’ atthe cost of ‘valuing diversity’ has meant that existing stereotypes and tensionswithin the ranks have remained, with dire consequences not only for thecohesiveness and effectiveness of the SANDF, but also for civil-military relations.

  9. THE SOUTH AFRICAN ARMED FORCES AND THEIR LINK WITH THE UNITED KINGDOM AND COMMONWEALTH OF NATIONS 1910-1961

    Directory of Open Access Journals (Sweden)

    R. Dale

    2012-02-01

    Full Text Available The Point of Departure: The Military Transfer Concept A cursory examination of the literature now available on the South African Defence Force would suggest that such literature contains an embarrassment of riches. A more careful scrutiny, however, suggests that. in terms of nominal measurement. it can be grouped into fairly discrete categories covering the first (1880-1881 and second (1899-1902 Anglo-Boer Wars, World Wars I and II, the Korean conflict. and the growth of the South African Defence Force as a natural complement to the world isolation engendered by the pursuit of the policy of apartheid. The last category is more appropriately considered as part of the civil-military and foreign policy history of the Republic of South Africa because of the severance of the Commonwealth tie in 1961 and the declaration of the arms embargo against the Republic in 1963.

  10. Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats

    Science.gov (United States)

    2014-01-01

    Background and purpose Both the immobilization of the unaffected arm combined with physical therapy (forced arm use, FAU) and voluntary exercise (VE) as model for enriched environment are promising approaches to enhance recovery after stroke. The genomic mechanisms involved in long-term plasticity changes after different means of rehabilitative training post-stroke are largely unexplored. The present investigation explored the effects of these physical therapies on behavioral recovery and molecular markers of regeneration after experimental ischemia. Methods 42 Wistar rats were randomly treated with either forced arm use (FAU, 1-sleeve plaster cast onto unaffected limb at 8/10 days), voluntary exercise (VE, connection of a freely accessible running wheel to cage), or controls with no access to a running wheel for 10 days starting at 48 hours after photothrombotic stroke of the sensorimotor cortex. Functional outcome was measured using sensorimotor test before ischemia, after ischemia, after the training period of 10 days, at 3 and 4 weeks after ischemia. Global gene expression changes were assessed from the ipsi- and contralateral cortex and the hippocampus. Results FAU-treated animals demonstrated significantly improved functional recovery compared to the VE-treated group. Both were superior to cage control. A large number of genes are altered by both training paradigms in the ipsi- and contralateral cortex and the hippocampus. Overall, the extent of changes observed correlated well with the functional recovery obtained. One category of genes overrepresented in the gene set is linked to neuronal plasticity processes, containing marker genes such as the NMDA 2a receptor, PKC ζ, NTRK2, or MAP 1b. Conclusions We show that physical training after photothrombotic stroke significantly and permanently improves functional recovery after stroke, and that forced arm training is clearly superior to voluntary running training. The behavioral outcomes seen correlate with

  11. [Contribution of the French Armed Forces Health Services to relief in Indonesia following the tsunami on December 26, 2004].

    Science.gov (United States)

    Meynard, J B; Nau, A; Halbert, E; Lelaidier, M; Robin, F; Todesco, A

    2005-01-01

    As of early January 2005, the French Armed Forces Health Services were on the ground in Indonesia to contribute to relief operations following the tsunami in Indonesia on December 26, 2004. Findings of preliminary investigation performed upon deployment of the first French elements demonstrated that a major priority was to speed up vaccination against measles in children between the ages of 6 months and 15 years. A vaccination campaign was planned in cooperation with Indonesian authorities and UNICEF. Implementation involved training of personnel and setting up vaccination clinics in refugee camps, schools, and neighborhoods in the city of Meulaboh. The vaccination campaign was hampered by a number of problems in particular involving logistics and required constant supervision. A survey to evaluate the results of the campaign in terms of vaccination coverage showed that the objective of vaccinating 70% of children in refugee camps was achieved. The survey provided other child health indicators that will be helpful to local authorities taking over after the departure of the French Armed Forces Health Services. PMID:16038345

  12. [Information analytical support of the US Armed Forces Medical Service at the theater of operations (review of foreign online publications)].

    Science.gov (United States)

    Agapitov, A A; Golota, A S; Krassiĭ, A B; Kuvakin, V I

    2013-05-01

    The current article is dedicated to the modern state of information analytical support of the US Armed Forces Medical Service at the theater of operations. It is shown that at the present time for that purpose it is employed the Joint Theater Medical Information Program (TMIP) which integrates all medically significant information in a single system. The described program covers the whole evacuation chain, specifically, wounded registration on the battle field, treatment conduction at the stages of evacuation, including the aeromobile evacuation, treatment and rehabilitation at specialized establishments in the United States, subsequent veteran care after retirement. It also provides paperless documents circulation and telemedicine needs, takes into consideration the certain Armed Forces components peculiarities, satisfies the information analytical requirements of the commanding body of the medical service. The main TMIP subprograms are introduced, namely: AHLTA, TMDS, MSAT, TMIP-M, MMM, TC2, NCAT, and the basic providing and supporting unit DHIMS is described. Finally, it is mentioned that currently the TMIP project starts to be used not only on the battlefield but at the garrisons as well and it is supposed that it will gradually expand to the entire national health care system.

  13. Bridge Maintenance Robotic Arm:Mechanical Technique to Reduce the Nozzle Force of a Sandblastine Rig

    Institute of Scientific and Technical Information of China (English)

    Nathan Kirchner; Gavin Paul; D.K. Liu

    2006-01-01

    This paper describes a mechanical technique to reduce the nozzle reaction force of a sandblasting rig. A theoretical evaluation of the magnitudes and direction of action of typical sandblasting nozzle forces has been conducted and a technique for exploiting available energy in order to reduce the magnitude of the forces at the nozzle has been developed.Experimental results from a variety of tests in different configurations have confirmed the theoretically determined force magnitude's accuracy and shown that forces of up to 106N can be present in typical sandblasting operations. The results have also shown that an up to 77% reduction of force at the nozzle can be achieved by applying the developed mechanicaltechnique.

  14. The effect of swinging the arms on muscle activation and production of leg force during ski skating at different skiing speeds.

    Science.gov (United States)

    Göpfert, Caroline; Lindinger, Stefan J; Ohtonen, Olli; Rapp, Walter; Müller, Erich; Linnamo, Vesa

    2016-06-01

    The study investigated the effects of arm swing during leg push-off in V2-alternate/G4 skating on neuromuscular activation and force production by the leg muscles. Nine skilled cross-country skiers performed V2-alternate skating without poles at moderate, high, and maximal speeds, both with free (SWING) and restricted arm swing (NOSWING). Maximal speed was 5% greater in SWING (Pskiing economy at moderate and, in particularly, high speeds.

  15. Radiobiology and radiation protection. Recent developments and future trends in radiobiology

    International Nuclear Information System (INIS)

    The 28th annual meeting of the Fachverband fuer Strahlenschutz, held from October 23 - 25, 1996 in Hannover, discussed the various aspects of the leading theme, radiation protection and radiobiology, recent developments and future trends in radiobiology. The papers presented in the proceedings volume address the three main aspects: (1) Mechanisms of the radiation effects - molecular and cellular mechanisms, genetic and prenatal radiation effects, cancerogenesis and mutagenesis; (2) Novel methods in radiobiology research: microdosimetry from the biological angle, novel methods in molecular biology including computerized simulation of DNA, methods of biological dosimetry, radiobiological aspects of neutrons and other densely ionizing radiation (Pt, Rn); (3) Knowledge and concepts for radiological protection: individual radiosensitivity, radiobiological aspects in medical applications of ionizing radiation, accidents in industry, radiation exposure in aeronautics and astronautics. (vhe)

  16. Factor which cause a level of physical readiness of servicemen of the Land forces of armed forces of Ukraine

    Directory of Open Access Journals (Sweden)

    Finogenov U.S.

    2010-10-01

    Full Text Available The level of physical readiness of officers of different age is construed. According to tests of the national charter on physical preparation 564 officers have been inspected. In addition with 395 officers the conducted army test of physical fitness was. Age decrease of parameters of physical readiness is exhibited. The authentic falling of a level of a velocity and force (in the age of 30-35 years, common endurance and a level of common physical readiness (in the age of 40-45 years is established. Among major factors of influence on a level of physical readiness of officers are: age, a stress, presence of harmful habits (smoking, surplus weight of a body.

  17. ASPECTS OF SOCIAL RESPONSIBILITY OF THE ARMED FORCES ACADEMY OF GEN. M.R.ŠTEFÁNIK, LIPTOVSKÝ MIKULÁŠ, SLOVAKIA

    Directory of Open Access Journals (Sweden)

    Soňa JIRÁSKOVÁ

    2014-10-01

    Full Text Available The article deals with the issue of socially responsible behavior in organizations, while the main emphasis is on the social responsibility of universities. The first part of the article briefly describes the concept of social responsibility and the second part presents a case study on the current state of activities related to socially responsible behavior within the Armed Forces Academy of gen. M. R. Štefánik in Liptovský Mikuláš. CSR activities which were implemented at the Armed Forces Academy of gen. M. R. Štefánik can be an example of good practice for other universities in Slovakia and abroad.

  18. [Health conditions and physical development of soldiers during enrollment in the Armed Forces of Ukraine and military service in 2001-2010].

    Science.gov (United States)

    Didenko, L V; Ustinova, L A; Khyzhniak, M I

    2012-01-01

    Fitness of soldiers in military reserve for military service at the stage in the Armed Forces of Ukraine has been studied in the article. It has been established that the growing number of soldiers in military reserve with changes in health and physical condition indicates insufficient level of their health which has a negative impact on their capability and gradually on their fitness for military service. Priorities of changes in organization of the process of completion by human resources of the soldiers' military reserve in the Armed Forces of Ukraine during their transition towards professional army have been defined, to include optimization of criteria of fitness for military service.

  19. Energy and Security: future-oriented studies for the Swedish Armed Forces; Energi och saekerhet: framtidsinriktade omvaerldsanalyser foer Foersvarsmakten

    Energy Technology Data Exchange (ETDEWEB)

    Oestensson, Malin; Jonsson, Daniel K.; Magnusson, Roger; Dreborg, Karl Henrik

    2009-01-15

    The report provides a basis for the Armed Forces long-term planning, and how changes in the global energy supply may mean new challenges and threats, as well as the advantages and disadvantages that can be associated with different future energy solutions for Armed Forces own activities, primarily relating to fuel and power during operation. One conclusion is that the potential conflict between energy security and climate-security can lead to far-reaching security implications and that continued global fossil dependency contributes to increased safety of political and military focus on a number of potential conflicts. A new such area may be the Arctic, as in the wake of climate change will become available for exploitation. Large scale global renewable energy can bring greater geographical spread - and reduced pressure on existing 'hot-spots'. Nuclear power is unlikely to be influential in the overall global energy security, but security problems associated with the production of nuclear materials can spread and be strengthened. Furthermore, the energy problems of connected to gaps between rich and poor, which may lead to social friction and conflict. The trend toward increased nationalisation and politicization of the energy is in contrast to free trade and market liberalism and may lead to further militarization of energy resources. Bilateral energy contracts may result in division within the EU and create a hindrance to joint positions and actions, such as in international efforts. As for Armed Forces own future energy solutions, the knowledge of alternative fuels (eg alcohols, diesel variants, gaseous fuels) and energy converters (eg hybrid vehicles, fuel cells) is reviewed. The following alternative principle solutions fuel and power are discussed: 1. Power from small-scale electricity generation via solar cells and small wind farms and power stations with liquid fuel as a supplement. Transport with plug-in hybrid vehicles, i.e. liquid propellants in

  20. Optimización de la agudeza visual en las FAS Optimization of visual acuity in Spanish Armed Forces

    Directory of Open Access Journals (Sweden)

    J. Medin Catoira

    2011-06-01

    Full Text Available Introducción: La existencia de una agudeza visual óptima es requerida para la mayor parte de las actividades del personal de las FAS, pero se hace estrictamente necesaria en el despliegue dentro del teatro de operaciones internacional. Material y Método: Hemos realizado un estudio sobre el registro de la agudeza visual en un grupo aleatorio (n = 54 durante los reconocimientos periódicos de permanencia realizados en nuestro centro. Resultados: Sólo 3 casos (5,56% reconocen ver mal; 20 (37,04% han utilizado corrección en algún momento de su vida; 12 (22,22% utilizan corrección; en 32 (60,38% sería altamente recomendable el uso de corrección. Ningún caso (0% de los usuarios de corrección posee corrección de repuesto (en gafas. Conclusión: Se hace incidencia en el control y registro de los parámetros visuales en el personal de las FAS, especialmente en actividades de riesgo y despliegue internacional.Introduction: The existence of an optimal visual acuity is required for most of the activities of the membrers of the Armed Forces, but it is strictly necessary in the deployment within the international theater. Materials and Methods: We conducted a study of visual acuity in a random group of periodical surveys in our center. Results: Only 3 cases (5.56% recognize look bad; 20 (37.04% have used correction at some point in their lives; 12 (22.22% used correction; in 32 cases (60.38% was highly recommended the use of correction. No cases (0% of users of correction has a duplicate of it (in glasses. Conclusions: The study suggests the need for better surveillance and control of visual parameters of the Armed Forces members, especially in risky activities and international deployment.

  1. Adverse events following vaccination in the French armed forces: An overview of surveillance conducted from 2002 to 2010.

    Science.gov (United States)

    Mayet, A; Haus-Cheymol, R; Bouaiti, E A; Decam, C; Simon, F; Mérens, A; Spiegel, A; Meynard, J B; Deparis, X; Migliani, R

    2012-06-14

    French military personnel are subject to a compulsory vaccination schedule. The aim of this study was to describe vaccine adverse events (VAE) reported from 2002 to 2010 in armed forces. VAE are routinely surveyed by the military Centre for epidemiology and public health. For each case, military practitioners fill a notification form, providing patient characteristics, clinical information and vaccines administered. For this study, VAE following influenza A(H1N1)pdm09 vaccination were excluded. Among the 473 cases retained, 442 (93%) corresponded to non-severe VAE,including local, regional and systemic events, while 31 corresponded to severe VAE, with two leading to significant disability. The global VAE reporting rate (RR) was 14.0 per 100,000 injections. While stationary from 2002 to 2008, the RR increased from 2009. The most important observations were a marked increase of VAE attributed to Bacillus Calmette-Guérin (BCG) vaccine from 2005 to 2008, a high RR observed with the inactivated diphtheria-tetanus (toxoids)-poliovirus vaccine combined with acellular pertussis vaccine (dTap-IPV) from 2008 and an increase in RR for seasonal influenza vaccine VAE in 2009. Our RR for severe VAE (1.1 VAEper 100,000) appears comparable with rates observed among United States civilians and military personnel. The increase observed from 2009 could be partly explained by the influenza A(H1N1)pdm09 pandemic which increased practitioner awareness towards VAE. In conclusion, the tolerance of the vaccines used in French armed forces appears acceptable.

  2. National Radiobiology Archives distributed access programmer's guide

    International Nuclear Information System (INIS)

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of the software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives

  3. Introduction to radiobiology of targeted radionuclide therapy

    Directory of Open Access Journals (Sweden)

    Jean-Pierre ePOUGET

    2015-03-01

    Full Text Available During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRT are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellular mechanisms involved in the radiation response. Most of the knowledge about radiation effects concerns external beam radiation therapy (EBRT and radiobiology has then strongly contributed to the development of this therapeutic approach. Similarly, radiobiology and dosimetry are also assumed to be ways for improving TRT, in particular in the therapy of solid tumors which are radioresistant. However, extrapolation of EBRT radiobiology to TRT is not straightforward. Indeed, the specific physical characteristics of TRT (heterogeneous and mixed irradiation, protracted exposure and low absorbed dose rate differ from those of conventional EBRT (homogeneous irradiation, short exposure and high absorbed dose rate, and consequently the response of irradiated tissues might be different. Therefore, specific TRT radiobiology needs to be explored. Determining dose-effect correlation is also a prerequisite for rigorous preclinical radiobiology studies because dosimetry provides the necessary referential to all TRT situations. It is required too for developing patient-tailored TRT in the clinic in order to estimate the best dose for tumor control, while protecting the healthy tissues, thereby improving therapeutic efficacy. Finally, it will allow to determine the relative contribution of targeted effects (assumed to be dose-related and non-targeted effects (assumed to be non-dose-related of ionizing radiation. However, conversely to EBRT where it is routinely used, dosimetry is still challenging in TRT. Therefore, it constitutes with radiobiology, one of the main

  4. A Climatology of Midlatitude Continental Clouds from the ARM SGP Site. Part II; Cloud Fraction and Surface Radiative Forcing

    Science.gov (United States)

    Xi, B.; Minnis, P.

    2006-01-01

    Data collected at the Department of Energy Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Central Facility (SCF) are analyzed to determine the monthly and hourly variations of cloud fraction and radiative forcing between January 1997 and December 2002. Cloud fractions are estimated for total cloud cover and for single-layered low (0-3 km), middle (3-6 km), and high clouds (more than 6 km) using ARM SCG ground-based paired lidar-radar measurements. Shortwave (SW) and longwave (LW) fluxes are derived from up- and down-looking standard precision spectral pyranometers and precision infrared radiometer measurements with uncertainties of approximately 10 Wm(exp -2). The annual averages of total, and single-layered low, middle and high cloud fractions are 0.49, 0.11, 0.03, and 0.17, respectively. Both total and low cloud amounts peak during January and February and reach a minimum during July and August, high clouds occur more frequently than other types of clouds with a peak in summer. The average annual downwelling surface SW fluxes for total and low clouds (151 and 138 Wm(exp-2), respectively) are less than those under middle and high clouds (188 and 201 Wm(exp -2), respectively), but the downwelling LW fluxes (349 and 356 Wm(exp -2)) underneath total and low clouds are greater than those from middle and high clouds (337 and 333 Wm(exp -2)). Low clouds produce the largest LW warming (55 Wm(exp -2) and SW cooling (-91 Wm(exp -2)) effects with maximum and minimum absolute values in spring and summer, respectively. High clouds have the smallest LW warming (17 Wm(exp -2)) and SW cooling (-37 Wm(exp -2)) effects at the surface. All-sky SW CRF decreases and LW CRF increases with increasing cloud fraction with mean slopes of -0.984 and 0.616 Wm(exp -2)%(exp -1), respectively. Over the entire diurnal cycle, clouds deplete the amount of surface insolation more than they add to the downwelling LW flux. The calculated CRFs do not appear to be significantly

  5. The mental health of the UK Armed Forces: where facts meet fiction

    Directory of Open Access Journals (Sweden)

    Elizabeth J. F. Hunt

    2014-08-01

    Full Text Available A substantial amount of research has been conducted into the mental health of the UK military in recent years. This article summarises the results of the various studies and offers possible explanations for differences in findings between the UK and other allied nations. Post-traumatic stress disorder (PTSD rates are perhaps surprisingly low amongst British forces, with prevalence rates of around 4% in personnel who have deployed, rising to 6% in combat troops, despite the high tempo of operations in recent years. The rates in personnel currently on operations are consistently lower than these. Explanations for the lower PTSD prevalence in British troops include variations in combat exposures, demographic differences, higher leader to enlisted soldier ratios, shorter operational tour lengths and differences in access to long-term health care between countries. Delayed-onset PTSD was recently found to be more common than previously supposed, accounting for nearly half of all PTSD cases; however, many of these had sub-syndromal PTSD predating the onset of the full disorder. Rates of common mental health disorders in UK troops are similar or higher to those of the general population, and overall operational deployments are not associated with an increase in mental health problems in UK regular forces. However, there does appear to be a correlation between both deployment and increased alcohol misuse and post-deployment violence in combat troops. Unlike for regular forces, there is an overall association between deployment and mental health problems in Reservists. There have been growing concerns regarding mild traumatic brain injury, though this appears to be low in British troops with an overall prevalence of 4.4% in comparison with 15% in the US military. The current strategies for detection and treatment of mental health problems in British forces are also described. The stance of the UK military is that psychological welfare of troops is

  6. Command-wide teleradiology for U.S. armed forces in Korea

    Science.gov (United States)

    Mun, Seong K.; Bryant, Gordon V.; Young, Harold; Sheehy, Monet R.; Willis, Charles E.; Goeringer, Fred

    1992-07-01

    There are 17 U.S. military medical treatment facilities scattered in the Republic of Korea to provide health care for approximately 40,000 U.S. troops and their dependents. Only three Army and one Air Force radiologist are assigned for radiological diagnosis. In some areas, report turn-around time can be as long as two weeks. An extensive teleradiology network is planned as part of an MDIS implementation program to improve the quality of radiological service overcoming the distance and time barriers.

  7. Soft x rays for radiobiological studies

    International Nuclear Information System (INIS)

    Lethal effects and chromosome aberrations induced in cells exposed to low energy (soft) X rays demonstrated that these relatively low energy X rays are just as effective as those of higher energy for radiobiological studies, and even more effective for irradiating cultured mammalian cells than laboratory animals. (author)

  8. Radiobiological and clinical aspects of neutron therapy

    International Nuclear Information System (INIS)

    Radiobiological investigations and their interpretation are discussed. The history of neutrontherapy, the results of RBE-investigations in man as well as clinical results are given. The hypothesis on reaction of human tissue and tumours towards neutron irradiation is presented. (A.S.)

  9. National Radiobiology Archives Distributed Access user's manual

    International Nuclear Information System (INIS)

    This User's Manual describes installation and use of the National Radiobiology Archives (NRA) Distributed Access package. The package consists of a distributed subset of information representative of the NRA databases and database access software which provide an introduction to the scope and style of the NRA Information Systems

  10. FACING CHILD SOLDIERS, MORAL ISSUES, AND “REAL SOLDIERING”: ANTHROPOLOGICAL PERSPECTIVES ON PROFESSIONAL ARMED FORCES*

    Directory of Open Access Journals (Sweden)

    Eyal Ben-Ari

    2011-08-01

    Full Text Available In today’s world, adolescents and children sometimes act as combatants whodirectly participate in hostilities. Yet more often they are deployed as auxiliaries (forexample, as lookouts or messengers or in various support roles (as gardening, roadmaintenance, delivery of food, cleaning, cooking, conveying goods and providingsexual services (Boothby and Knudsen 2000. Finally, under certain circumstances,adolescents and children may be used as human shields or for propaganda purposesby government or opposition forces (Boyden and De Berry 2004:xii; United Nations2002:13. Since the late 1970s, a number of international conventions have beenpromulgated to limit the use of these young people, but children continue to bedeployed in parts of the world and overwhelmingly in sub-Saharan Africa. Estimatesas to their numbers vary. Human Rights Watch (2007, a human rights lobby,estimates that there are between 200 000 and 300 000 such youngsters in armedconflicts in over twenty countries.

  11. A Climatology of Midlatitude Continental Clouds from the ARM SGP Central Facility. Part II; Cloud Fraction and Radiative Forcing

    Science.gov (United States)

    Dong, Xiquan; Xi, Baike; Minnis, Patrick

    2006-01-01

    Data collected at the Department of Energy Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) central facility are analyzed for determining the variability of cloud fraction and radiative forcing at several temporal scales between January 1997 and December 2002. Cloud fractions are estimated for total cloud cover and for single-layer low (0-3 km), middle (3-6 km), and high clouds (greater than 6 km) using ARM SGP ground-based paired lidar-radar measurements. Shortwave (SW), longwave (LW), and net cloud radiative forcings (CRF) are derived from up- and down-looking standard precision spectral pyranometers and precision infrared radiometer measurements. The annual averages of total, and single-layer, nonoverlapped low, middle and high cloud fractions are 0.49, 0.11, 0.03, and 0.17, respectively. Total and low cloud amounts were greatest from December through March and least during July and August. The monthly variation of high cloud amount is relatively small with a broad maximum from May to August. During winter, total cloud cover varies diurnally with a small amplitude, mid-morning maximum and early evening minimum, and during summer it changes by more than 0.14 over the daily cycle with a pronounced early evening minimum. The diurnal variations of mean single-layer cloud cover change with season and cloud height. Annual averages of all-sky, total, and single-layer high, middle, and low LW CRFs are 21.4, 40.2, 16.7, 27.2, and 55.0 Wm(sup -2), respectively; and their SW CRFs are -41.5, -77.2, -37.0, -47.0, and -90.5 Wm(sup -2). Their net CRFs range from -20 to -37 Wm(sup -2). For all-sky, total, and low clouds, the maximum negative net CRFs of -40.1, -70, and -69.5 Wm(sup -2), occur during April; while the respective minimum values of -3.9, -5.7, and -4.6 Wm(sup -2), are found during December. July is the month having maximum negative net CRF of -46.2 Wm(sup -2) for middle clouds, and May has the maximum value of -45.9 Wm(sup -2) for high clouds. An

  12. Hello Music Lady: Have You Brought A New Instrument Today? A Music Therapy Group for Children of Families in the UK Armed Forces.

    Directory of Open Access Journals (Sweden)

    Becky White

    2009-11-01

    Full Text Available The paper describes a music therapy group that took place in a UK primary school on an armed forces base.  The school described is the only state school in the UK for families in the armed forces.  The families staying on the base are in transition for reasons such as, family break-up, domestic problems, leaving the forces, emergency evacuation from overseas, and transition between postings.  This paper traces how the group evolved over eleven months.  It focuses on the practical considerations required when setting up a music therapy group.  It describes the thought processes I went through in doing this work, and looks at how the work was integrated into the school.  It considers the setting up of the group, providing a framework, working with staff, structuring the sessions, and how the group ended. 

  13. The impact of an educational film on promoting knowledge and attitudes toward HIV in soldiers of the Serbian armed forces

    Directory of Open Access Journals (Sweden)

    Jadranin Željko

    2015-01-01

    Full Text Available Background/Aim. Millions of soldiers around the world represent one of the most vulnerable populations regarding exposure to human immunodeficiency virus (HIV infection. The programs for HIV prevention remain the most viable approach to reducing the spread of HIV infection. Very few studies have tested the effectiveness of HIV preventive interventions undertaken in military population. The aim of this study was to determine the effectiveness of educational film to transfer knowledge about HIV infection to soldiers. Methods. We performed a quasi-experimental study among 102 soldiers of the Serbian Armed Forces. The experimental intervention consisted of the HIV knowledge pre-questionnaire, watching a film on HIV knowledge, then the post-HIV knowledge questionnaire. The results of pre-and post-HIV knowledge questionnaires were compared. Results. There were 23 questions in the test. The average total score on the questionnaire before watching the film was 18.23 and after watching it was 20.14, which was statistically significant difference (p < 0.001. Conclusions. The results of the study show that viewing a film on HIV infection is an effective method of transferring knowledge about HIV to the Serbian military population.

  14. Impact on mental health of deploying as an individual augmentee in the U.K. Armed Forces.

    Science.gov (United States)

    Sundin, Josefin; Mulligan, Kathleen; Henry, Sophie; Hull, Lisa; Jones, Norman; Greenberg, Neil; Wessely, Simon; Fear, Nicola T

    2012-05-01

    Armed Forces personnel who deploy as individual augmentees (IAs), with a unit other than their formed unit, often fill shortages or provide specialized knowledge or skill sets. This article examined the effect of deploying as an IA on mental health outcomes and unit cohesion. A U.K. military cohort study was used to compare IAs (n = 1352) with personnel who had deployed with a formed unit (n = 2980). Differences between the groups in questionnaire assessed symptoms of post-traumatic stress disorder (PTSD Checklist-Civilian Version), common mental disorders (General Health Questionnaire-12) and alcohol misuse (Alcohol Use Disorders Identification Test) were examined with logistic and negative-binomial regression analyses. There was no difference between IAs and those who deployed with a formed unit in level of unit cohesion, symptoms of post-traumatic stress disorder or common mental disorder. Deployment as an IA was associated with less alcohol misuse (Odds Ratio 0.77, 95% Confidence Interval 0.63-0.94). IAs appeared able to integrate with the group they deployed with as levels of unit cohesion were similar to personnel who deployed with a formed unit. IAs were also at a lower risk of alcohol misuse compared to personnel who deployed with a formed unit.

  15. Workshop on radiobiological effectiveness of neutrons

    International Nuclear Information System (INIS)

    The radiobiological effectiveness (RBE) of neutrons has become the subject of some heated discussions in both scientific and radiation-protection oriented communities. This has become especially so since the realization that neutron exposures of A-bomb survivors in Hiroshima were considerably lower than previously assumed, thus ''devaluating'' the importance of what we thought was a solid human data base. At the same time, more recent data from radiobiological research appeared to indicate that, at least for some biological endpoints, the RBE of neutrons at low doses and low dose rates was increased dramatically compared to the RBE at higher dose and dose rates. As a consequence, the protection of health against neutrons became a subject of some urgency. The objective of this workshop was to evaluate the existing data base in order to determine the need for additional research in this field. 22 refs., 3 figs., 6 tabs

  16. The arms race control

    International Nuclear Information System (INIS)

    Written in 1961, this paper presents the content of a book entitled 'The arms race control' where the author outlined the difference between disarmament and arms control, described the economic and moral role of arms race, the importance of force balance for international security. He wandered whether arms control could ensure this balance and whether nuclear balance meant force balance. Force balance then appears to be a precarious and unsteady component of international security. He commented the challenges of disarmament, recalled some arguments for a nuclear disarmament. Then he discussed what would be an arms control with or without disarmament (either nuclear or conventional)

  17. Scientific projection paper for space radiobiological research

    International Nuclear Information System (INIS)

    A nationale for the radiobiological research requirements for space is rooted in a national commitment to the exploration of space, mandated in the form of the National Space Act. This research is almost entirely centered on man; more specifically, on the effects of the space radiation environment on man and his protection from them. The research needs discussed in this presentation include the space radiation environment; dosimetry; radiation biology-high LET particles (dose/response); and operational countermeasures

  18. The Fundamentals of Imaging Physics and Radiobiology

    CERN Document Server

    Selman, Joseph

    2000-01-01

    Like its well-known predecessor, this new and expanded Ninth Edition presents numerous important changes, beginning with the title and continuing throughout the text. Drawing on current knowledge and his own extensive experience, Dr. Selman provides a thorough revision and overview of each previously included chapter. Definitions, foundations, and principles are presented along with changes in methods and procedures. The text presents five new chapters on computed tomography, radioactivity and diagnostic nuclear medicine, radiobiology, protection in radiology/health physics, and nonradiologic

  19. Dosimetry for radiobiology experiments at GANIL

    Science.gov (United States)

    Durantel, Florent; Balanzat, Emmanuel; Cassimi, Amine; Chevalier, François; Ngono-Ravache, Yvette; Madi, Toiammou; Poully, Jean-Christophe; Ramillon, Jean-Marc; Rothard, Hermann; Ropars, Frédéric; Schwob, Lucas; Testard, Isabelle; Saintigny, Yannick

    2016-04-01

    Mainly encouraged by the increasing application of ion beams for cancer treatment (hadron-therapy) including carbon beams, the use of heavy ion facilities for radiobiology is expanding rapidly today. As an alternative to dedicated centers for treatment and medical research, accelerators like GANIL offer the possibility to undertake such experiments. Since 20 years, CIMAP, reinforced 15 years ago by the biological host laboratory LARIA, has been receiving researchers in radiobiology and assisted them in performing experiments in different fields such as hadron-therapy, space radioprotection and fundamental biological and physico-chemical mechanisms. We present here a short description of the beam line and the on-line equipments that allow the automatic irradiation of up to 24 biological samples at once. We also developed an original on-line beam monitoring procedure for low ion flux (low dose rates) based on the measurement of the K-shell X-rays emitted from a thin iron foil. This detector is calibrated on an absolute scale before each experiment by counting etched tracks on an irradiated CR39 polymer plate. We present the performances and limits of this method and finally give typical fluence (dose) uncertainties for a standard irradiation in radiobiology.

  20. Employer attractiveness of the Swedish Armed Forces : A quantitative study of gender differences and the effects of employer brand attributes and social media in the government authority sector

    OpenAIRE

    Jorlöv, Karin; Venngren, Emma

    2014-01-01

    The main purpose of this degree project has been to examine the effects of employer brand attributes and activities on social media to the employer attractiveness of the Swedish Armed Forces. We aimed to make theoretical contributions to the fields of employer branding and social media marketing, and test a unique conceptual model for the government authority. The conceptual model focuses on employer brand attributes that have previously been connected to employer attractiveness in this type ...

  1. Automobile or other conveyance and adaptive equipment certificate of eligibility for veterans or members of the armed forces with amyotrophic lateral sclerosis. Interim final rule.

    Science.gov (United States)

    2015-02-25

    The Department of Veterans Affairs (VA) is amending its adjudication regulation regarding certificates of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment. The amendment authorizes automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected amyotrophic lateral sclerosis (ALS) and members of the Armed Forces serving on active duty with ALS.

  2. STRATEGIC KNOWLEDGE MANAGEMENT IN THE ARMED FORCES ACADEMY OF GENERAL M. R. ŠTEFÁNIK IN LIPTOVSKÝ MIKULÁŠ, THE SLOVAK REPUBLIC

    OpenAIRE

    Mária PETRUFOVÁ

    2015-01-01

    The article stresses the importance of strategic knowledge management in the era of global competition. Strategic knowledge management raises the demand for permanent learning stressing the visions and personal aspirations of everyone within the modern effi cient organisation. Within the AFA of General M.R. Štefánik and, inherently, in the Armed Forces of the Slovak Republic, strategic knowledge management employs and implements knowledge as the ultimate step in the knowledge pyramid.

  3. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings

    International Nuclear Information System (INIS)

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  4. A Prospective Study of Renal Biopsies Performed Over One-year at the Riyadh Armed Forces Hospital

    Directory of Open Access Journals (Sweden)

    Mousa D

    2000-01-01

    Full Text Available A prospective study of all native kidney biopsies performed over one year at the Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia was conducted. During this period, 52 kidney biopsies were performed of which, 49 had adequate tissue. All biopsies were processed for light microscopy, immunofluorescence and electron microscopy. The indications for biopsy included the nephrotic syndrome (n=28; 53.8%, asymptomatic proteinuria (n=12; 21.2%, acute nephritic presentation (n=7; 13.5% and asymptomatic hematuria (n=7; 13.5%. Primary glomerulonephritis (GN, excluding IgA nephropathy (IgAN was seen in 34 of the 49 patients (77.6%. Focal and segmental glomerulosclerosis and mesangial proliferative GN were the most common histological diagnoses (31% and 20.4% respectively. Surprisingly, we found a high prevalence of IgA nephropathy (IgAN of 14.5% in comparison with other studies. The prevalence of mesangiocapillary glomerulonephritis (MCGN was low (2% and can only be explained as incidental. The study patients were followed-up for an average of 26.3 weeks. At the end of the observation period, 50% has unchanged course, 37.5% had improved their renal function and protein excretion, and 12.5% had deteriorated. The prognosis of different GN groups and renal survival rate cannot be assessed or calculated in this study because of the relatively short duration of follow-up. Our study further emphasizes the need for a national GN registry and long-term follow-up, in order to recognize the common patterns of GN, their natural histories, the appropriate line of management, and to try and arrest their progression to end-stage renal disease.

  5. Physics and radiobiology of nuclear medicine

    CERN Document Server

    Saha, Gopal B

    2010-01-01

    From a distinguished author comes this new edition for technologists, practitioners, residents, and students in radiology and nuclear medicine. Encompassing major topics in nuclear medicine from the basic physics of radioactive decay to instrumentation and radiobiology, it is an ideal review for Board and Registry examinations. The material is well organized and written with clarity. The book is supplemented with tables and illustrations throughout. It provides a quick reference book that is concise but comprehensive, and offers a complete discussion of topics for the nuclear medicine and radi

  6. Radiation monitoring considerations for radiobiology facilities

    International Nuclear Information System (INIS)

    Battelle, Pacific Northwest Laboratories, conducts a wide variety of radiobiology and radioecology research in a number of facilities on the Hanford Reservation. Review of radiation monitoring problems associated with storage, plant and animal experiments, waste handling and sterile facilities shows that careful monitoring, strict procedural controls and innovative techniques are required to minimize occupational exposure and control contamination. Although a wide variety of radioactivity levels are involved, much of the work is with extremely low level materials. Monitoring low level work is mundane and often impractical but cannot be ignored in today's ever tightening controls

  7. Radiobiological studies using gamma and x rays.

    Energy Technology Data Exchange (ETDEWEB)

    Potter, Charles Augustus; Longley, Susan W.; Scott, Bobby R.; Lin, Yong; Wilder, Julie; Hutt, Julie A.; Padilla, Mabel T.; Gott, Katherine M.

    2013-02-01

    There are approximately 500 self-shielded research irradiators used in various facilities throughout the U.S. These facilities use radioactive sources containing either 137Cs or 60Co for a variety of biological investigations. A report from the National Academy of Sciences[1] described the issues with security of particular radiation sources and the desire for their replacement. The participants in this effort prepared two peer-reviewed publications to document the results of radiobiological studies performed using photons from 320-kV x rays and 137Cs on cell cultures and mice. The effectiveness of X rays was shown to vary with cell type.

  8. Generalized calculus in radiobiology: Physical implications

    CERN Document Server

    Sotolongo-Grau, O; Antoranz, J C; Sotolongo-Costa, Oscar

    2009-01-01

    Non-extensive statistical physics has allowed to generalize mathematical functions such as exponential and logarithms. The same framework is used to generalize sum and product so that the operations allow a more fluid way to work with mathematical expressions emerging from non-additive formulation of statistical physics. In this work we employ the generalization of the exponential, logarithm and product to obtain a formula for the survival fraction corresponding to the application of several radiation doses on a living tissue. Also we provide experimental recommendations to determine the universal characteristics of living tissues in interaction with radiation. These results have a potential application in radiobiology and radiation oncology.

  9. Melanomas: radiobiology and role of radiation therapy

    International Nuclear Information System (INIS)

    Purpose/Objective: This course will review the radiobiology of malignant melanoma (MM) and the clinical use of radiation therapy for metastatic melanoma and selected primary sites. The course will emphasize the scientific principles underlying the clinical treatment of MM. Introduction: The incidence of malignant melanoma has one of the fastest growth rates in the world. In 1991, there were 32,000 cases and 7,000 deaths from MM in the United States. By the year 2000, one of every 90 Americans will develop MM. Wide local excision is the treatment of choice for Stage I-II cutaneous MM. Five-year survival rates depend on (a) sex: female-63%, male-40%; (b) tumor thickness: t 4 mm-25%; (c) location: extremity-60%, trunk-41%; and (d) regional lymph node status: negative-77%, positive-31%. Despite adequate surgery, 45-50% of all MM patients will develop metastatic disease. Radiobiology: Both the multi-target model: S = 1-(1-e-D/Do)n and the linear quadratic mode: -In(S) = alpha x D + beta x D2 predict a possible benefit for high dose per fraction (> 400 cGy) radiation therapy for some MM cell lines. The extrapolation number (n) varies from 1-100 for MM compared to other mammalian cells with n=2-4. The alpha/beta ratios for a variety of MM cell lines vary from 1 to 33. Other radiobiologic factors (repair of potentially lethal damage, hypoxia, reoxygenation, and repopulation) predict a wide variety of clinical responses to different time-dose prescriptions including high dose per fraction (> 400 cGy), low dose per fraction (200-300 cGy), or b.i.d. therapy. Based on a review of the radiobiology of MM, no single therapeutic strategy emerges which could be expected to be successful for all tumors. Time-Dose Prescriptions: A review of the retrospective and prospective clinical trials evaluating various time-dose prescriptions for MM reveals: (1) MM is a radiosensitive tumor over a wide range of diverse time-dose prescriptions; and (2) The high clinical response rates to a

  10. The dental specialties related articles published in Medical Journal Armed Forces India from 2000 to 2014 over a 15-year period.

    Science.gov (United States)

    Shamim, Thorakkal

    2015-12-01

    There is a paucity of information about the dental specialties related articles published in the Medical Journal Armed Forces India (MJAFI). This study aimed to audit the dental specialities related articles published in MJAFI from 2000 to 2014 over a 15-year period. Bibliometric analysis of sixty issues of MJAFI from 2000 to 2014 were performed using web-based search. The articles published were analyzed for type of article and topic of individual dental specialities. The articles published were also evaluated to identify whether the study was an Armed Forces Medical Research Committee Project or funded research project or not. Out of the total 118 published articles related to dental specialities, original articles (55) and case reports (49) contribute the major share. The highest number of dental specialities related articles was published in 2009 with 16, followed by 2010 with 13 and 2011 with 11 and the least published year was 2013 with 3 articles. Regarding the relationship with dental specialities, the maximum number of published articles were related to oral medicine and radiology (56) followed by oral and maxillofacial surgery (49), orthodontics (23) and prosthodontics (17). Among the articles published in MJAFI, maxillofacial injuries (11) followed by orthodontic treatment (8) and craniofacial deformities (8) form the major attraction of the contributors. Among the 118 dental speciality articles, there were only 4 Armed Forces Medical Research Committee Project articles and 19 funded research project articles. An equal distribution of articles related to clinical dentistry and nonclinical dentistry is maintained for the MJAFI from 2000 to 2014 over a 15-year period. PMID:26858474

  11. The dental specialties related articles published in Medical Journal Armed Forces India from 2000 to 2014 over a 15-year period.

    Science.gov (United States)

    Shamim, Thorakkal

    2015-12-01

    There is a paucity of information about the dental specialties related articles published in the Medical Journal Armed Forces India (MJAFI). This study aimed to audit the dental specialities related articles published in MJAFI from 2000 to 2014 over a 15-year period. Bibliometric analysis of sixty issues of MJAFI from 2000 to 2014 were performed using web-based search. The articles published were analyzed for type of article and topic of individual dental specialities. The articles published were also evaluated to identify whether the study was an Armed Forces Medical Research Committee Project or funded research project or not. Out of the total 118 published articles related to dental specialities, original articles (55) and case reports (49) contribute the major share. The highest number of dental specialities related articles was published in 2009 with 16, followed by 2010 with 13 and 2011 with 11 and the least published year was 2013 with 3 articles. Regarding the relationship with dental specialities, the maximum number of published articles were related to oral medicine and radiology (56) followed by oral and maxillofacial surgery (49), orthodontics (23) and prosthodontics (17). Among the articles published in MJAFI, maxillofacial injuries (11) followed by orthodontic treatment (8) and craniofacial deformities (8) form the major attraction of the contributors. Among the 118 dental speciality articles, there were only 4 Armed Forces Medical Research Committee Project articles and 19 funded research project articles. An equal distribution of articles related to clinical dentistry and nonclinical dentistry is maintained for the MJAFI from 2000 to 2014 over a 15-year period.

  12. Self-Rated Health and its Relationship to Health/Life Problems and Coping Strategies in Members of the Professional Slovenian Armed Forces

    OpenAIRE

    Selic, Polona; Petek, Davorina; Serec, Masa; Rus Makovec, Maja

    2012-01-01

    The aim of this study was to test the association between self-rated health status (i.e. psychological and interpersonal welfare, physical health, coping mechanisms) and absence from work due to illness in the Slovenian armed forces. 390 military personnel were included in the study. Two groups of soldiers, healthy (G1-H) and sick/less healthy (G2-S), were created according to the median value of their annual sick leave. A third group consisted of soldiers on a mission (G3-M). A background qu...

  13. Study of the existing problems and public consciousness of the in-service military officers in Royal Thai Armed Forces Headquarters

    Directory of Open Access Journals (Sweden)

    Meepien Supawadee

    2016-01-01

    Full Text Available The public consciousness is an important characteristic which requires serious enhancement in Thailand. The objective of this study is to examine the existing problems and the public consciousness of the inservice military officers. As a result shows, there is currently no precise training system for public consciousness training at the Royal Thai Armed Forces Headquarters. The tasks are carried out by the chain of command. A study of the existing problems and the public consciousness could lead to the development of a training model to enhance public consciousness. If the in-service military officers, who would return to their hometown all over the country after being discharged, were to have public consciousness characteristics as a foundation for everyday life, the nation would head up the force to help society.

  14. Physics and radiobiology of nuclear medicine

    CERN Document Server

    Saha, Gopal B

    2013-01-01

    The Fourth Edition of Dr. Gopal B. Saha’s Physics and Radiobiology of Nuclear Medicine was prompted by the need to provide up-to-date information to keep pace with the perpetual growth and improvement in the instrumentation and techniques employed in nuclear medicine since the last edition published in 2006. Like previous editions, the book is intended for radiology and nuclear medicine residents to prepare for the American Board of Nuclear Medicine, American Board of Radiology, and American Board of Science in Nuclear Medicine examinations, all of which require a strong physics background. Additionally, the book will serve as a textbook on nuclear medicine physics for nuclear medicine technologists taking the Nuclear Medicine Technology Certification Board examination.

  15. BNL ACCELERATOR-BASED RADIOBIOLOGY FACILITIES

    Energy Technology Data Exchange (ETDEWEB)

    LOWENSTEIN,D.I.

    2000-05-28

    For the past several years, the Alternating Gradient Synchrotron (AGS) at Brookhaven National Laboratory (USA) has provided ions of iron, silicon and gold, at energies from 600 MeV/nucleon to 10 GeV/nucleon, for the US National Aeronautics and Space Administration (NASA) radiobiology research program. NASA has recently funded the construction of a new dedicated ion facility, the Booster Applications Facility (BAF). The Booster synchrotron will supply ion beams ranging from protons to gold, in an energy range from 40--3,000 MeV/nucleon with maximum beam intensities of 10{sup 10} to 10{sup 11} ions per pulse. The BAF Project is described and the future AGS and BAF operation plans are presented.

  16. 美军联合电子战消除频率冲突方式%Method to Eliminate Electronic Warfare Electromagnetic Frequencies Conflicts by US Armed Force

    Institute of Scientific and Technical Information of China (English)

    陈邓安; 丛中旖; 吴杰

    2012-01-01

    为在作战、通信和情报活动中协调地使用电磁频谱,对美军联合电子战消除频率冲突的方式进行研究.研究美军联合电子战消除频率冲突的程序和内容,介绍美军在联合电子战中分析频率冲突的2种方式,并分析美军联合部队各相关部门的职责.该研究可为提升我军电子战水平提供参考.%Under battle, communication and intelligence activity, in order to make good use of the electromagnetic spectrum, research the method to eliminate the electromagnetic frequencies conflicts by US armed force. Study the procedure of the US armed force dealing with electromagnetic frequencies conflicts, introduce the methods to analysis electromagnetic frequencies conflicts, and analysis the responsibility of the relevant departments, which can provides active reference for the coordination in the joint operations.

  17. Radiobiology with heavy charged particles: a historical review

    Energy Technology Data Exchange (ETDEWEB)

    Skarsgard, L.D. [Dept. of Medical Biophysics, B.C. Cancer Research Centre and TRIUMF, Vancouver (Canada)

    1997-09-01

    The presentation will attempt to briefly review some of radiobiological data on the effects of heavy charged particles and to discuss the influence of those studies on the clinical application which followed. (orig./MG)

  18. Radiobiology of Radiosurgery for the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Antonio Santacroce

    2013-01-01

    Full Text Available According to Leksell radiosurgery is defined as “the delivery of a single, high dose of irradiation to a small and critically located intracranial volume through the intact skull.” Before its birth in the early 60s and its introduction in clinical therapeutic protocols in late the 80s dose application in radiation therapy of the brain for benign and malignant lesions was based on the administration of cumulative dose into a variable number of fractions. The rationale of dose fractionation is to lessen the risk of injury of normal tissue surrounding the target volume. Radiobiological studies of cell culture lines of malignant tumors and clinical experience with patients treated with conventional fractionated radiotherapy helped establishing this radiobiological principle. Radiosurgery provides a single high dose of radiation which translates into a specific toxic radiobiological response. Radiobiological investigations to study the effect of high dose focused radiation on the central nervous system began in late the 50s. It is well known currently that radiobiological principles applied for dose fractionation are not reproducible when single high dose of ionizing radiation is delivered. A review of the literature about radiobiology of radiosurgery for the central nervous system is presented.

  19. The Canadian Armed Forces “YouTube War”: A Cross-Border Military-Social Media Complex

    OpenAIRE

    Tanner Mirrlees

    2015-01-01

    The goal of this paper is to conceptualize, contextualize, and critically analyze the Canadian Armed Forces’ (CAF) use of YouTube to promote itself, recruit soldiers, and frame its role in the post-9/11 U.S.-led NATO war in Afghanistan. The first section of this paper engages with scholarship on war and the media, the military-industrial-communications complex (MICC), and YouTube War to conceptualize YouTube as a tool and contested battle-space of 21st century new media wars. The second secti...

  20. 武警基层干部压力源问卷的编制%The development of stress scale for cadres of Chinese people's armed police forces

    Institute of Scientific and Technical Information of China (English)

    许爱萍; 孙丽云; 刘红; 王宪利

    2011-01-01

    目的 编制符合武警部队基层干部压力源的问卷.方法 编制武警基层干部压力源问卷,以802名基层干部为研究对象,数据使用项目分析、因素分析、信度分析、效度分析等统计学方法验证其结构.结果 因素分析结果表明,19个题目可以分为4个因素:职业压力、经济压力、人际压力和发展压力.问卷总体一致性信度为0.893,分半信度系数为0.812,重测信度为0.813.该问卷总压力与症状自评量表中的躯体化、焦虑、抑郁、人际关系敏感等因子有较高程度的正相关,相关系数分别为0.376,0.383,0.396,0.387(P<0.05).结论 武警基层干部压力问卷具有良好的信、效度,可以作为压力源测量的使用工具.%Objective To develop cadres' stress scale for the Chinese people' s armed police forces.Methods Based on the stress theory and principles of the psychometrics,combined with characteristics of armed police forces. The cadres' stress scale was developed by ourselves. 802 cadres were evaluated as samples and statistic the data by item analysis ,factor analysis, reliability and valid analysis. Results The scale included four dimensions: task stress, economy stress, interpersonal stress and development stress. The internal consistency reliability was 0.893 ,the split-half reliability coefficient was 0.812. Retest reliability coefficient was 0.813. The criterion related validity to the stress scale and SCL-90 was good and the correlation coefficient with somatization, anxiety,depression, interpersonal sensitivity was 0. 376,0. 383,0. 396,0. 387 individually (P < 0.05 ). Conclusion Cadres stress scale for cadres of Chinese people's armed police forces has good reliability and validity.

  1. In vitro irradiation system for radiobiological experiments

    International Nuclear Information System (INIS)

    Although two-dimensional (2-D) monolayer cell cultures provide important information on basic tumor biology and radiobiology, they are not representative of the complexity of three-dimensional (3-D) solid tumors. In particular, new models reproducing clinical conditions as closely as possible are needed for radiobiological studies to provide information that can be translated from bench to bedside. We developed a novel system for the irradiation, under sterile conditions, of 3-D tumor spheroids, the in vitro model considered as a bridge between the complex architectural organization of in vivo tumors and the very simple one of in vitro monolayer cell cultures. The system exploits the same equipment as that used for patient treatments, without the need for dedicated and highly expensive instruments. To mimic the passage of radiation beams through human tissues before they reach the target tumor mass, 96-multiwell plates containing the multicellular tumor spheroids (MCTS) are inserted into a custom-built phantom made of plexiglass, the material most similar to water, the main component of human tissue. The system was used to irradiate CAEP- and A549-derived MCTS, pre-treated or not with 20 μM cisplatin, with a dose of 20 Gy delivered in one session. We also tested the same treatment schemes on monolayer CAEP and A549 cells. Our preliminary results indicated a significant increment in radiotoxicity 20 days after the end of irradiation in the CAEP spheroids pre-treated with cisplatin compared to those treated with cisplatin or irradiation alone. Conversely, the effect of the radio- chemotherapy combination in A549-derived MCTS was similar to that induced by cisplatin or irradiation alone. Finally, the 20 Gy dose did not affect cell survival in monolayer CAEP and A549 cells, whereas cisplatin or cisplatin plus radiation caused 100% cell death, regardless of the type of cell line used. We set up a system for the irradiation, under sterile conditions, of tumor cells

  2. Automobile or Other Conveyance and Adaptive Equipment Certificate of Eligibility for Veterans or Members of the Armed Forces With Amyotrophic Lateral Sclerosis Connected to Military Service. Final rule.

    Science.gov (United States)

    2016-01-13

    The Department of Veterans Affairs (VA) published an Interim Final Rule on February 25, 2015, to amend its adjudication regulations to provide a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment for all veterans with service-connected amyotrophic lateral sclerosis (ALS) and servicemembers serving on active duty with ALS. The amendment authorized automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected ALS and members of the Armed Forces serving on active duty with ALS. The intent of this final rule is to confirm the amendment made by the interim final rule without change.

  3. Biophysical and biomathematical adventures in radiobiology

    International Nuclear Information System (INIS)

    Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing ''state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing ''hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone marrow to large doses of photon radiation, low rates of exposure should be better tolerated than high rates; and (3) for some types of radiation (e.g., alpha particles and fission neutrons), moderate doses delivered at a low rate may be more harmful than the same dose given at a high rate. 53 refs., 7 figs

  4. Assessment of Ration Scales of the Armed Forces Personnel in Meeting theNutritional Needs at Plains and High Altitudes–I

    Directory of Open Access Journals (Sweden)

    S.T Babusha

    2008-11-01

    Full Text Available Adequate nutrition is very essential, especially for the Armed Forces, to buildup their nutritional reserveswhile deriving maximum benefits of training/peak performances in operational situations by keeping theirmorale high. The present study reviews/examines the adequacy of the existing ration scales of the ArmedForces personnel stationed under different terrain conditions of the country/recruits at various training centres.Food samples were collected from different strategic locations during different seasons of the year and analysedfor their nutrient composition like proximal constituents, vitamins A, E, B1, B2, C, and dietary fibre. Basedon the data generated, the daily nutrients/energy consumption by the soldiers/recruits, were calculated separatelyboth for personnel in plains and at high altitudes. Soldiers in plains, on an average consumed protein 124.2+ 13.0 g, fat 98.8 + 29.6 g and energy 3632+317 kcal/person/day, while their counterparts at high altitudesconsumed protein 120.4 + 11.2 g, fat 120.1 + 31.1 g, and energy 3906 + 423 kcal/person/day. The study clearlyindicate that the present ration scales for the Service personnel, both in plains and at high altitudes (9000 ftto 15000 ft is adequate wrt their nutrient density. It is however suggested to ensure adequate supply of goodquality fresh vegetables, fruits, and meat, which inturn would not only help to keep the morale of the soldiers,high and cheerful, especially at high altitudes, but will also enable adequate micronutrient availability. Thefibre levels in the diets of these soldiers have also been found to be well within the limits (20 -35 g/ person/day recommended for optimal health.Defence Science Journal, 2008, 58(6, pp.734-744, DOI:http://dx.doi.org/10.14429/dsj.58.1701

  5. The Freedom of Expression of Members of the Armed Forces Under the European Convention on Human Rights In Jokšas V. Lithuania

    Directory of Open Access Journals (Sweden)

    Kirchner Stefan

    2014-06-01

    Full Text Available Freedom of expression is one of the most fundamental rights in a democratic society. In fact, the freedom to express one’s opinion and to impart, as well as to receive, information, is essential for the participation in the democratic process. The ability to make decisions as a citizen requires access to information; the participation in the life of the society requires the ability to express one’s opinions. It is imperative that in a democratic society, as it is envisaged by the European Convention on Human Rights (ECHR, everybody is able to express their views, regardless as to whether these views correspond to the views of those who are in power. This ability is one of the key differences between democracy anddictatorship. In particular in the nation-states of Eastern Europe, which have only known freedom for a bit less than a quarter of a century, the growth of democratic structures is inextricably linked to the ability to exercise this right. But while human rights in principle pit the citizen against the State, the citizen who serves the State in a professional function might also wish to express opinions that go against the view of those who are entrusted with leading the State. This is particularly the case when it comes to members of the armed forces. The jurisprudence of the Convention organs with regard to the right of public officials and other State agents to express their opinion freely is not as coherent as it is with regard to other questions concerning the ECHR. In a case decided in late 2013, the European Court of Human Rights dealt with this question with regard to Lithuania. In this article, the authors look at the question of how far the State can restrict the freedom of expression of members of the armed forces under the European Convention on Human Rights.

  6. Toward a national consensus: teaching radiobiology to radiation oncology residents

    International Nuclear Information System (INIS)

    Purpose: The ASTRO Joint Working Group on Radiobiology Teaching, a committee composed of members having affiliations with several national radiation oncology and biology-related societies and organizations, commissioned a survey designed to address issues of manpower, curriculum standardization, and instructor feedback as they relate to resident training in radiation biology. Methods and Materials: Radiation biology instructors at U.S. radiation oncology training programs were identified and asked to respond to a comprehensive electronic questionnaire dealing with instructor educational background, radiation biology course content, and sources of feedback with respect to curriculum planning and resident performance on standardized radiation biology examinations. Results: Eighty-five radiation biology instructors were identified, representing 73 radiation oncology residency training programs. A total of 52 analyzable responses to the questionnaire were received, corresponding to a response rate of 61.2%. Conclusion: There is a decreasing supply of instructors qualified to teach classic, and to some extent, clinical, radiobiology to radiation oncology residents. Additionally, those instructors with classic training in radiobiology are less likely to be comfortable teaching cancer molecular biology or other topics in cancer biology. Thus, a gap exists in teaching the whole complement of cancer and radiobiology curricula, particularly in those programs in which the sole responsibility for teaching falls to one faculty member (50% of training programs are in this category). On average, the percentage of total teaching time devoted to classic radiobiology (50%), clinical radiobiology (30%), and molecular and cancer biology (20%) is appropriate, relative to the current makeup of the board examination. Nevertheless large variability exists between training programs with respect to the total number of contact hours per complete radiobiology course (ranging from

  7. EXPERIMENTAL–DIDACTIC STAND FOR THE ANALYSIS OF INFLUENCE OF THE MAGNETHOREOLOGICAL DAMPER ON THE THRUST FORCE IN SMALL CALIBER ARMS

    Directory of Open Access Journals (Sweden)

    Marcin BAJKOWSKI

    2014-06-01

    Full Text Available This paper presents the laboratory stand, designed for research and didactic purposes. The stand allows investigating the performance of the programmable system for controlling the recoil effect in the small caliber arm–shooter configuration. The system incorporates synchronized magnetorheological (MR damper. The aim of the study is to describe the influence of the damping of a high-energy pulse from small caliber arm, on the value of the thrust force. For the considered set of MR dampers the range of the operating currents for the MR coil is experimentally selected and adjusted. In the study of the results the emphasis is put on the influence of MR damper on the force characteristics, which directly affects the accuracy of the weapon. The obtained results show that the proposed system special object–MR damper–shooter, has a major, positive effect on the accuracy by reducing the components of the recoil. A scheme of the laboratory stand is presented. Basic parameters of the investigated system and research results are discussed

  8. The Social Media Policy of U.S. Armed Forces in the Information Security Perspective%美军在信息安全视野下利用社交媒体政策研究

    Institute of Scientific and Technical Information of China (English)

    周殷夏; 白文杰

    2012-01-01

    近年来,美军逐步调整社交媒体政策,重视发挥其在公共事务、家庭服务以及塑造军队形象中的独特功能。从信息安全的角度出发,在分析美军社交媒体政策发展变化及其内在动因的基础上,总结出美军运用社交媒体所采取的信息安全措施。%In recent years, the U. S. armed forces gradually adjust the social media policy to attach impor- tance of its unique features in public affairs, family services, as well as shaping the image of the Armed Forces. From the perspective of information security, this article on the basis of the analysis of the U. S. armed forces social media policy development and changes in their intrinsic motivations, summed up the information security measures taken by the U.S. armed forces using social media.

  9. National Radiobiology Archives distributed access programmer's guide

    Energy Technology Data Exchange (ETDEWEB)

    Prather, J. C. [Linfield Coll., McMinnville, OR (United States); Smith, S. K.; Watson, C. R. [Pacific Northwest Lab., Richland, WA (United States)

    1991-12-01

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of the software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives.

  10. [History of malaria control in the French armed forces: from Algeria to the Macedonian front during the first World War].

    Science.gov (United States)

    Migliani, R; Meynard, J-B; Milleliri, J-M; Verret, C; Rapp, C

    2014-01-01

    The French joint military health corps has long experience in malaria control. Many military physicians played an essential role in the 19th century: Maillot revolutionized malaria treatment by using quinine during the conquest of Algeria, and Laveran discovered the causal parasite (the genus Plasmodium) there. This experience continued under the direction of Laveran and the Sergent brothers on the eastern front in Greek Macedonia during World War I. The vast coordinated control plan established on this front from 1917 delivered the French infantrymen from malaria and led to victory over the Bulgarian forces, which capitulated in September 1918.

  11. Contribution of the Mission in Afghanistan to the Burden of Past-Year Mental Disorders in Canadian Armed Forces Personnel, 2013

    Science.gov (United States)

    Zamorski, Mark A.

    2016-01-01

    Objective: The purpose of this study was to estimate the contribution of the mission in Afghanistan to the burden of mental health problems in the Canadian Armed Forces (CAF). Methods: Data were obtained from the 2013 Canadian Forces Mental Health Survey, which assessed mental disorders using the World Health Organization’s Composite International Diagnostic Interview. The sample consisted of 6696 Regular Force (RegF) personnel, 3384 of whom had deployed in support of the mission. We estimated the association of past-year mental health problems with Afghanistan deployment status, adjusting for covariates using logistic regression; population attributable fractions (PAFs) were also calculated. Results: Indication of a past-year mental disorder was identified in 18.4% (95% confidence interval [CI], 17.0% to 19.7%) of Afghanistan deployers compared with 14.6% (95% CI, 13.3% to 15.8%) in others. Afghanistan-related deployments contributed to the burden of a past-year disorder (PAF = 8.7%; 95% CI, 3.0% to 14.2%), with the highest PAFs being seen for panic disorder (34.7%) and posttraumatic stress disorder (32.1%). The PAFs for individual alcohol use disorders and suicide ideation were not different from zero. Child abuse, however, had a much greater PAF for any past-year disorder (28.7%; 95% CI, 23.4% to 33.7%) than did the Afghanistan mission. Conclusions: The mission in Afghanistan contributed significantly to the burden of mental disorders in the CAF RegF in 2013. However, the much stronger contribution of child abuse highlights the need for strong military mental health systems, even in peacetime, and the need to target the full range of determinants of mental health in prevention and control efforts. PMID:27270744

  12. Incidence of hiatal hernia in service members, active component, U.S. Armed Forces, 2005-2014.

    Science.gov (United States)

    O'Donnell, Francis L; Taubman, Stephen B

    2016-08-01

    From 2005 through 2014, a total of 27,276 active component service members had incident diagnoses of hiatal hernia documented in their medical records. The overall incidence rate was 19.7 cases per 10,000 person-years (p-yrs); annual incidence rates ranged from 16.5 to 22.2 cases per 10,000 p-yrs. Rates overall increased monotonically with increasing age and were higher among Air Force and Army members, officers, and healthcare workers than their respective counterparts. During the surveillance period, the 27,276 service members who had incident diagnoses of hiatal hernia accounted for 44,092 hiatal hernia-related encounters overall (1.6 encounters per case). Among all incident cases, 235 (0.86%) had surgical repairs documented during the period. The frequency of surgical treatment of hiatal hernias among military members mirrored the low frequency in U.S. civilian practice. During 2010-2014, most surgical procedures (79%) were accomplished via laparoscopic approaches. The incidence rates of hiatal hernia diagnoses reported here likely greatly underestimate the true incidence in U.S. military populations. Reasons for the underestimates and comparisons with other populations are discussed.

  13. In vivo tumor radiobiology of heavy charged particles

    International Nuclear Information System (INIS)

    The response of tumor cells systems to irradiation with carbon, neon and argon beams at various positions in the plateau and extended-peak regions of the Bragg ionization curve is being evaluated from experiments conducted both in vivo and in vitro. The radiobiological end points being studied include: tumor volume response, cellular survival after tumor irradiation in situ, and cell-kinetic parameters

  14. Research in radiobiology. Annual report, Internal Irradiation Program

    International Nuclear Information System (INIS)

    The annual progress report for the Radiobiology Division of the University of Utah College of Medicine is presented. Summaries of twenty-four projects concerning the metabolism, dosimetry and toxicity of a variety of actinide elements in beagles or rats are given. Individual papers within this report have been separately indexed and abstracted for the data base

  15. National Radiobiology Archives Distributed Access user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Watson, C.; Smith, S. (Pacific Northwest Lab., Richland, WA (United States)); Prather, J. (Linfield Coll., McMinnville, OR (United States))

    1991-11-01

    This User's Manual describes installation and use of the National Radiobiology Archives (NRA) Distributed Access package. The package consists of a distributed subset of information representative of the NRA databases and database access software which provide an introduction to the scope and style of the NRA Information Systems.

  16. [The directions of activity of the medical service on prophylaxis and early revealing of tuberculosis in the Armed Forces of the Russian Federation].

    Science.gov (United States)

    Khalimov, Iu Sh; Beznosik, R V; Shitov, Iu N; Dantsev, V V; Muchaidze, R D

    2012-07-01

    The basic directions of system of antituberculous actions in the Armed Forces of the Russian Federation includes: 1) non-admission of citizens, sick of tuberculosis, on military service; 2) allocation of group of persons with the raised risk of tuberculosis among all military servicemen, dispensary dynamic supervision over them and carrying out of chemoprophylaxis; 3) revealing of tuberculosis among military servicemen at preventive medical inspections (including fluorography), and also in case of reference for medical aid with the symptoms specifying on possibility of tuberculosis; 4) carrying out antiepidemic actions in military unit, in case of revealing patient, sick of tuberculosis, well-timed, qualitatively and in full. The major stage of antituberculous actions is a profound medical examination of young reinforcement (recruits under service call and under the contract) after the arrival in army. Preventive actions in group of persons with the raised risk of tuberculosis also are a priority for the medical service of military unit. Final desinfection, controllable emergency chemoprophylaxis and extraordinary fluorography of contact persons under epidemic indications are crucial important for decrease of morbidity in the army focuses of tuberculosis.

  17. La odontología forense en las Fuerzas Armadas: Una asignatura pendiente Forensic dentistry in the Armed Forces: an unresolved matter

    Directory of Open Access Journals (Sweden)

    A. Bel Blesa

    2011-12-01

    Full Text Available La odontología forense es una disciplina que está abriéndose paso en nuestras Fuerzas Armadas en respuesta a necesidades derivadas de la participación de España en misiones internacionales y al cumplimiento de lo acordado en el marco de la OTAN. Aún queda mucho camino que recorrer en lo referente a la identificación humana. Se analiza la situación actual referente a la Ficha de Identificación Odontológica en vigor y propone un nuevo modelo más acorde a los estándares internacionales.Forensic dentistry is an emerging discipline in our Armed Forces that answers the needs derived from the Spanish participation in overseas deployments and NATO agreements. There is still much to be done as far as human identification is concerned. The current Dental Identification Card is evaluated and a new model more in accordance with international standards is proposed.

  18. Experience of the air medical evacuation team of Serbian armed forces in the united nations mission in the Democratic Republic of Congo - deployment stress and psychological adaptation

    Directory of Open Access Journals (Sweden)

    Joković Danilo B.

    2016-01-01

    Full Text Available Background/Aim. Wars of the nineties in former Yugoslavia, Somalia, Rwanda imposed new tasks to the United Nations (UN forces, such as providing humanitarian aid, protection of civilians, peacekeeping, and in many instances providing armed enforcement of peace. The aim of this study was an observational analysis of Serbian participation in the UNs Mission in the Democratic Republic of Congo with the emphasis on stress and coping techniques. Methods. Serbian contribution in this mission dates back to April 2003 till the present days with a military contingent consisting of six members as a part of Air Medical Evacuation Team. The observed stressogenous factors acted before arrival to the mission area and in the mission area. In this paper we analysed ways to overcome them. Results. The productive ways of overwhelming stress used in this mission were: honesty and openness in interpersonal communications, dedication to work, maintaining discipline and order, strict following of appropriate regime of work, diet, rest and recreation; regular communication with family and organizing and participation in various social, cultural and sports manifestations. Conclusion. This analysis indicates that out of all the observed factors, the most important is appropriate selection of personnel.

  19. 美军联合电子战消除频率冲突研究%Research on Electromagnetic Frequencies Conflicts for US Armed Force Electronic Warfare

    Institute of Scientific and Technical Information of China (English)

    陈邓安; 李冬; 吴杰

    2011-01-01

    Under the complicated electromagnetic environment, in view of the topic about dealing with the electromagnetic frequencies conflicts, this article expatiate the procedure of the US armed force dealing with electromagnetic frequencies conflicts and the responsibility of the relevant departments, and the methods of dealing with electromagnetic frequencies conflicts, and provides active reference for the coordination in the joint operations.%针对电子战中的频率冲突问题,研究了美军联合电子战消除频率冲突的程序和内容,系统阐述了美军联合部队各相关部门的职责,分析了美军在联合电子战中消除电子战频率冲突的方式,为我军在未来联合作战中解决电磁频率冲突的相关问题提供参考。

  20. Expand and Implementation of the Armed Police Forces Telemedicine Network Platform%武警部队远程医学网络平台的拓展与实现

    Institute of Scientific and Technical Information of China (English)

    李颖; 张志荣; 王庆民

    2014-01-01

    Relying on the armed police forces has built wide area network, construction of telemedicine network platform, extend the armed police forces telemedicine network to the grass-roots Squadron. This article mainly elaborates the design and implementation process of network architecture, technical characteristics and problems.%依托武警部队已建成的广域网,构建远程医学网络平台,将武警部队远程医学网延伸到基层中队,重点对设计与实施过程中的网络架构、技术特点等问题进行了阐述。

  1. The relationship between wing length, blood meal volume, and fecundity for seven colonies of Anopheles species housed at the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

    Science.gov (United States)

    Phasomkusolsil, Siriporn; Pantuwattana, Kanchana; Tawong, Jaruwan; Khongtak, Weeraphan; Kertmanee, Yossasin; Monkanna, Nantaporn; Klein, Terry A; Kim, Heung-Chul; McCardle, Patrick W

    2015-12-01

    Established colonies of Anopheles campestris, Anopheles cracens, Anopheles dirus, Anopheles kleini, Anopheles minimus, Anopheles sawadwongporni, and Anopheles sinensis are maintained at the Armed Forces Research Institute of Medical Sciences (AFRIMS). Females were provided blood meals on human blood containing citrate as an anticoagulant using an artificial membrane feeder. The mean wing length, used as an estimate of body size, for each species was compared to blood-feeding duration (time), blood meal volume, and numbers of eggs oviposited. Except for An. campestris and An. cracens, there were significant interspecies differences in wing length. The mean blood meal volumes (mm(3)) of An. kleini and An. sinensis were significantly higher than the other 5 species. For all species, the ratios of unfed females weights/blood meal volumes were similar (range: 0.76-0.88), except for An. kleini (1.08) and An. cracens (0.52), that were significantly higher and lower, respectively. Adult females were allowed to feed undisturbed for 1, 3, and 5min intervals before blood feeding was interrupted. Except for An. campestris and An. sawadwongporni, the number of eggs oviposited were significantly higher for females that fed for 3min when compared to those that only fed for 1min. This information is critical to better understand the biology of colonized Anopheles spp. and their role in the transmission of malaria parasites as they relate to the relative size of adult females, mean volumes of blood of engorged females for each of the anopheline species, and the effect of blood feeding duration on specific blood meal volumes and fecundity.

  2. 德国联邦国防军心理卫勤工作%Mental Health Service in German Federal Armed Forces

    Institute of Scientific and Technical Information of China (English)

    冯杰; 李晨; 刘柳; 郭树森; 张建杰

    2011-01-01

    德国联邦国防军历来重视军事作业过程的心理因素,以及军事人员心理问题和心理疾病的预防.德军心理卫勤工作严格依照该国相关法律法规,确立心理卫生人员的执业范围及资质,建立健全相应管理制度和督导体系,其研究工作科学、系统,尤其重视实战应用.这些做法为我军心理卫勤工作发展、人员教育培训及管理体系健全等方面提供有益借鉴和参考.%The psychological factors of military operations usually are focused by The German Federal Armed Forces, as well as the prevention of psychological problems and mental illness in military personnel. The mental health - care work is in strict accordance with the Germany laws and regulations in army. The practice scope and qualification in mental health staff are limited by German Psychological Association, including the management system and supervision system. The focus of psychological service in army is to promote the practical fighting capacity. The measures of German are the useful references of Chinese peoples Liberation Army in the logistic support of mental health, the education & training of psychological specialist, and the perfection of management - supervision system.

  3. Delay to mental healthcare in a cohort of Canadian Armed Forces personnel with deployment-related mental disorders, 2002–2011: a retrospective cohort study

    Science.gov (United States)

    Boulos, David; Zamorski, Mark A

    2016-01-01

    Objective To assess whether the delay to care among Canadian Armed Forces (CAF) personnel who sought care for a mental disorder changed over time and in association with CAF mental health system augmentations. Design A stratified, random sample (n=2014) was selected for study from an Afghanistan-deployed cohort (N=30 513) and the 415 (weighted N=4108) individuals diagnosed with an Afghanistan service-related mental disorder were further assessed. Diagnosis-related data were abstracted from medical records (22 June 2010 to 30 May 2011). Other data were extracted from administrative databases. Delay to care was assessed across five mental health system eras: 2002/2004, 2005/2006, 2007, 2008 and 2009/2010. Weighted Cox proportional hazards regression assessed the association between era, handled as a time-dependent covariate, and the outcome while controlling for a broad range of potential confounders (ie, sociodemographic, military and clinical characteristics). Taylor series linearisation methods and sample design weights were applied in generating descriptive and regression analysis statistics. Primary outcome The outcome was the delay to mental healthcare, defined as the latency from most recent Afghanistan deployment return date to diagnosis date, among individuals with an Afghanistan service-related mental disorder diagnosis. Results Mean delay to care was 551 days (95% CI 501 to 602); the median was 400 days. Delay to care decreased in subsequent eras relative to 2002/2004; however, only the most recent era (2009/2010) was statistically significant (adjusted HR (aHR): 3.01 (95% CI 1.91 to 4.73)). Men, operations support occupations, higher ranks, non-musculoskeletal comorbidities and fewer years of military service were also independently associated with longer delays to care. Conclusions CAF mental health system changes were associated with reduced delays to mental healthcare. Further evaluation research is needed to identify the key system changes that

  4. Cardiomyopathies and the Armed Forces.

    Science.gov (United States)

    Holdsworth, D A; Cox, A T; Boos, C; Hardman, R; Sharma, S

    2015-09-01

    Cardiomyopathies are a group of heterogeneous myocardial diseases that are frequently inherited and are a recognised cause of premature sudden cardiac death in young individuals. Incomplete expressions of disease and the overlap with the physiological cardiac manifestations of regular intensive exercise create diagnostic challenges in young athletes and military recruits. Early identification is important because sudden death in the absence of prodromal symptoms is a common presentation, and there are several therapeutic strategies to minimise this risk. This paper examines the classification and clinical features of cardiomyopathies with specific reference to a military population and provides a detailed account of the optimum strategy for diagnosis, indications for specialist referral and specific guidance on the occupational significance of cardiomyopathy. A 27-year-old Lance Corporal Signaller presents to his Regimental medical officer (RMO) after feeling 'light-headed' following an 8 mile unloaded run. While waiting to see the RMO, the medical sergeant records a 12-lead ECG. The ECG is reviewed by the RMO immediately prior to the consultation and shows voltage criteria for left ventricular (LV) hypertrophy and inverted T-waves in II, III, aVF and V1-V3 (Figure 1). This Lance Corporal is a unit physical training instructor and engages in >10 h of aerobic exercise per week. He is a non-smoker and does not have any significant medical history. PMID:26246349

  5. Optimization in brachytherapy with the implementation of Radiobiology

    International Nuclear Information System (INIS)

    In the brachytherapy planning treatments with High dose rates (HDR), the optimization algorithms used are based in dosimetric considerations and/or geometric ones, ignoring the radiobiological response of the tissue treated. In this work we wish to show the implementation of radiobiological concepts in the optimization. Assuming that the subtiles differences that result in the dose distribution among the different optimization models which are not visible in an isodose plane, it is studied how is classically make it , the quality implant through natural histograms about dose volumes and the resulting parameters. Also is studied the necrosis probability which may be caused by the choice of some optimization model, allowing with this the choice of the best implant. (Author)

  6. Radiobiology Department. Report of Activities 1977-1980

    International Nuclear Information System (INIS)

    The different research activities carried out by the Radiobiology Department of the CNEA over the 4-year period 1977-1980 are summarized. These activities were devoted to the study of the effects of radiation on different biological systems, to the search for adequate experimental models, and to the development of techniques permiting a correct evaluation of the information obtained. Topics covered are genetics, microbiology, somatic effects of radiation, pathology and the operation of the animal's house. (M.E.L.)

  7. In vitro irradiation station for broad beam radiobiological experiments

    Science.gov (United States)

    Wéra, A.-C.; Riquier, H.; Heuskin, A.-C.; Michiels, C.; Lucas, S.

    2011-12-01

    The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.

  8. In vitro irradiation station for broad beam radiobiological experiments

    Energy Technology Data Exchange (ETDEWEB)

    Wera, A.-C., E-mail: anne-catharine.wera@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium); Riquier, H., E-mail: helene.riquier@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Unite de Recherche de Biologie Cellulaire (URBC), University of Namur-FUNDP, Rue de Bruxelles, 61, B-5000 Namur (Belgium); Heuskin, A.-C., E-mail: anne-catherine.heuskin@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium); Michiels, C., E-mail: carine.michiels@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Unite de Recherche de Biologie Cellulaire (URBC), University of Namur-FUNDP, Rue de Bruxelles, 61, B-5000 Namur (Belgium); Lucas, S., E-mail: stephane.lucas@fundp.ac.be [NAmur Research Institute for LIfe Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur-FUNDP (Belgium)

    2011-12-15

    The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.

  9. (RadioBiological Optimization of External-Beam Radiotherapy

    Directory of Open Access Journals (Sweden)

    Alan E. Nahum

    2012-01-01

    Full Text Available “Biological optimization” (BIOP means planning treatments using (radiobiological criteria and models, that is, tumour control probability and normal-tissue complication probability. Four different levels of BIOP are identified: Level I is “isotoxic” individualization of prescription dose at fixed fraction number. is varied to keep the NTCP of the organ at risk constant. Significant improvements in local control are expected for non-small-cell lung tumours. Level II involves the determination of an individualized isotoxic combination of and fractionation scheme. This approach is appropriate for “parallel” OARs (lung, parotids. Examples are given using our BioSuite software. Hypofractionated SABR for early-stage NSCLC is effectively Level-II BIOP. Level-III BIOP uses radiobiological functions as part of the inverse planning of IMRT, for example, maximizing TCP whilst not exceeding a given NTCP. This results in non-uniform target doses. The NTCP model parameters (reflecting tissue “architecture” drive the optimizer to emphasize different regions of the DVH, for example, penalising high doses for quasi-serial OARs such as rectum. Level-IV BIOP adds functional imaging information, for example, hypoxia or clonogen location, to Level III; examples are given of our prostate “dose painting” protocol, BioProp. The limitations of and uncertainties inherent in the radiobiological models are emphasized.

  10. Report on the behalf of the Foreign Affairs, Defense and Armed Forces Commission on the bill project, adopted by the National Assembly, related to the struggle against the proliferation of arms of massive destruction and their vectors

    International Nuclear Information System (INIS)

    This report recalls the origins of the bill project which is the implementation of the UN Security Council resolution 1540, the aim of which was to promote the setting up of efficient tools to struggle against proliferation. The bill project aims at updating and reinforcing the existing law arsenal. The report also contains remarks made by the Commission. The bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  11. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 20. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemannn, Hans-Peter; Zips, Daniel (eds.)

    2011-07-01

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  12. An Elastica Arm Scale

    CERN Document Server

    Bosi, F; Corso, F Dal; Bigoni, D

    2015-01-01

    The concept of 'deformable arm scale' (completely different from a traditional rigid arm balance) is theoretically introduced and experimentally validated. The idea is not intuitive, but is the result of nonlinear equilibrium kinematics of rods inducing configurational forces, so that deflection of the arms becomes necessary for the equilibrium, which would be impossible for a rigid system. In particular, the rigid arms of usual scales are replaced by a flexible elastic lamina, free of sliding in a frictionless and inclined sliding sleeve, which can reach a unique equilibrium configuration when two vertical dead loads are applied. Prototypes realized to demonstrate the feasibility of the system show a high accuracy in the measure of load within a certain range of use. It is finally shown that the presented results are strongly related to snaking of confined beams, with implications on locomotion of serpents, plumbing, and smart oil drilling.

  13. 武警某部新兵艾滋病健康教育研究%Research of health education on AIDS in recruits of Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    郭宏霞; 李浴峰; 曹春霞; 单学娴

    2012-01-01

    OBJECTIVE To explore the influence of health education on AIDS related knowledge attitude and practice in CPAPF (Chinese People's Armed Police Forces). To provide scientific evidences for making health education mode of preventing AIDS in CPAPF. METHODS Cluster sampling was used to select 1 500 CPAPF recruits. Used the approach of expert lecture, making web page and materials, training pioneers for one year health education, compared the awareness rate of related knowledge attitude, practice to AIDS before and after intervention. RESULTS The awareness rate of AIDS related knowledge, attitude, practice after intervention was significantly higher than before (P< 0.05). CPAPF soldier's favorite education patterns were lectureship, video, handbook, games, discussion, folding. 69.2% of soldiers accepted the health education. CONCLU- ' SION Active health education can improve awareness rates of AIDS related knowledge and change attitude, practice.%目的 研究健康教育对武警战士艾滋病相关知识态度行为的影响,为探讨武警部队艾滋病健康教育模式提供科学依据.方法 采用整群抽样的方法抽取武警某部1 500名新兵,采取专家专题巡讲、网页与传播材科制作、规范培训骨干等方式进行为期1年的健康教育,比较干预前后战士艾滋病相关知识知晓率和相关态度、行为持有率.结果 干预后艾滋病基本知识知晓率、态度及行为持有率高于教育前,差异有统计学意义(P< 0.05).战士最受欢迎的教育方式依次是讲座、录像、手册、活动或游戏、集体讨论、展板、折页.最佳受教育时间依次为平时加强、新兵入伍.69.2%的战士认为健康教育效果很好.结论 采取多样化的健康教育方式能积极促进战士艾滋病相关知识知晓率的提高和态度、行为的改变.

  14. Do soldiers seek more mental health care after deployment? Analysis of mental health consultations in the Netherlands Armed Forces following deployment to Afghanistan

    Directory of Open Access Journals (Sweden)

    Elisabeth (Liesbeth M. Taal

    2014-08-01

    Full Text Available Background: Military deployment to combat zones puts military personnel to a number of physical and mental challenges that may adversely affect mental health. Until now, few studies have been performed in Europe on mental health utilization after military deployment. Objective: We compared the incidence of mental health consultations with the Military Mental Health Service (MMHS of military deployed to Afghanistan to that of non-deployed military personnel. Method: We assessed utilization of the MMHS by the full cohort of the Netherlands Armed Forces enlisted between 2008 and 2010 through linkage of mental health and human resource information systems. Results: The total population consisted of 50,508 military (18,233 deployed, 32,275 non-deployed, who accounted for 1,906 new consultations with the MMHS. The follow-up was limited to the first 2 years following deployment. We observed higher mental health care utilization in deployed vs. non-deployed military personnel; hazard ratio (HR, adjusted for sex, military branch and time in service, 1.84 [95% CI 1.61–2.11] in the first and 1.28 [1.09–1.49] in the second year after deployment. An increased risk of adjustment disorders (HR 2.59 [2.02–3.32] and 1.74 [1.30–2.32] and of anxiety disorders (2.22 [1.52–3.25] and 2.28 [1.50–3.45] including posttraumatic stress disorder (5.15 [2.55–10.40] and 5.28 [2.42–11.50], but not of mood disorders (1.33 [0.90–1.97] and 1.11 [0.68–1.82], was observed in deployed personnel in the first- and second-year post-deployment, respectively. Military personnel deployed in a unit with a higher risk of confrontation with potentially traumatic events had a higher HR (2.13 [1.84–2.47] and 1.40 [1.18–1.67]. Conclusions: Though absolute risk was low, in the first and second year following deployment to Afghanistan there was an 80 and 30% higher risk for mental health problems resulting in a consultation with the Dutch MMHS compared to military never

  15. 美军伊拉克和阿富汗战争战伤救治新理念%New concepts of combat trauma care in the US Armed Forces during Operation Enduring Freedom and Operation Iraqi Freedom

    Institute of Scientific and Technical Information of China (English)

    李丽娟; 刁天喜

    2013-01-01

    The tactical combat casualty care (TCCC) concept,first introduced by the US Navy Special Warfare Command in 1996 and used in the conflicts in Iraq and Afghanistan,has become the standard in all services in the US Armed Forces,which is also one of the major advances that the US Armed Forces achieved during Operation Iraqi Freedom(OIF)and Operation Enduring Freedom(OEF).The new concept of TCCC has brought the US military casualties to a record low in the nation's history.This paper describes the development of the TCCC by the US Armed Forces,discusses the three phases of TCCC care,investigates its organization and implementation and finally puts forward some lessons China can learn.%“战术战伤救治”的概念最早由美海军特种作战部队于1996年首次提出,在伊拉克和阿富汗战争中成为美军战术环境中伤员救治的标准规范,也是美军伊拉克和阿富汗战争中战伤救治取得的一大进展.战术战伤救治的应用使美军达到了有史以来最低的伤亡率.该文梳理了美军战术战伤救治理念的发展,分析了战术战伤救治的阶段划分,探讨了美军战术战伤救治的组织实施,并提出了对我军的启示.

  16. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings

    International Nuclear Information System (INIS)

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity

  17. Robotic arm

    Science.gov (United States)

    Kwech, Horst

    1989-04-18

    A robotic arm positionable within a nuclear vessel by access through a small diameter opening and having a mounting tube supported within the vessel and mounting a plurality of arm sections for movement lengthwise of the mounting tube as well as for movement out of a window provided in the wall of the mounting tube. An end effector, such as a grinding head or welding element, at an operating end of the robotic arm, can be located and operated within the nuclear vessel through movement derived from six different axes of motion provided by mounting and drive connections between arm sections of the robotic arm. The movements are achieved by operation of remotely-controllable servo motors, all of which are mounted at a control end of the robotic arm to be outside the nuclear vessel.

  18. Children In Armed Conflicts

    OpenAIRE

    Ranjan, Tejaswini

    2013-01-01

    This is a descriptive study. A child soldier is a child under the age of 18 that is recruited into the armed forces and engages in political violence. Child Soldiers are recruited by a state or non-state armed group and used as fighters, cooks, suicide bombers, human shields, messengers, spies, or for sexual purposes. This work of research describes the plight of child soldiers taking in context the scenario of different nations. The International mechanisms to combat this problem have also b...

  19. An irradiation facility with a vertical beam for radiobiological studies

    CERN Document Server

    Besserer, J; Dellert, M; Gahn, C; Moosburger, M; Pemler, P; Quicken, P; Distel, L; Schuessler, H

    1999-01-01

    A vertical beam facility for radiobiological experiments was designed and constructed at the Munich Tandem-Accelerator Laboratory. The main part of the facility is a 90 deg. dipole magnet bending the beam of protons or heavy particles into a vertical upward direction, which is advantageous for wet-cell irradiation. After collimation the beam is spread out passively by thin scattering foils and dynamically by magnetic coils. A homogeneity of the radiation field better than +-5% has been achieved over the diameter of the exit window of 60 mm. The dose rate can be widely adjusted from single particles to more than 10 sup 1 sup 0 particles (i.e. hundreds of Grays) per second. The dose measurement is based on single-particle counting and on standard dosimeters. The detector system for dosimetry and irradiation control is described. In a first radiobiological experiment the cell survival of chinese hamster cells was measured after irradiation with 22.7 MeV protons and compared with the X-ray result.

  20. Hypofractionation in prostate cancer: radiobiological basis and clinical appliance.

    Science.gov (United States)

    Mangoni, M; Desideri, I; Detti, B; Bonomo, P; Greto, D; Paiar, F; Simontacchi, G; Meattini, I; Scoccianti, S; Masoni, T; Ciabatti, C; Turkaj, A; Serni, S; Minervini, A; Gacci, M; Carini, M; Livi, L

    2014-01-01

    External beam radiation therapy with conventional fractionation to a total dose of 76-80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α / β . Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose) demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting. PMID:24999475

  1. Hypofractionation in Prostate Cancer: Radiobiological Basis and Clinical Appliance

    Directory of Open Access Journals (Sweden)

    M. Mangoni

    2014-01-01

    Full Text Available External beam radiation therapy with conventional fractionation to a total dose of 76–80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α/β. Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting.

  2. Some applications of radiation chemistry to biochemistry and radiobiology

    International Nuclear Information System (INIS)

    In this chapter illustrate the use of radiation chemistry as a tool in investigating biologically important radical reactions, and also outline some studies of models for radiobiological damage. Because aqueous solutions usually offer the most important matrix, an appreciation of the main features of water radiolysis will be essential. Most of the illustrations involve pulse radiolysis, and some familiarity with chemical kinetics is assumed. In addition to these and other chapters in this book, readers find the proceedings of a recent NATO Advanced Study Institute most useful. The authors shall not try to review here all the applications of radiation chemistry to biochemistry and biology, but they will illustrate, using selected examples, the main principles and practical advantages and problems. Another recent volume covers the main contributions of flash photolysis and pulse radiolysis to the chemistry of biology and medicine, complementing earlier reviews. Papers from symposia on radical processes in radiobiology and carcinogenesis, and on super-oxide dismutases, and proceedings of recent international congresses of radiation research, together with the other publications referred to above will enable the reader to gain a comprehensive overview of the role of radicals in biological processes and the contributions of radiation chemistry

  3. Influence of oxygen on the chemical stage of radiobiological mechanism

    Science.gov (United States)

    Barilla, Jiří; Lokajíček, Miloš V.; Pisaková, Hana; Simr, Pavel

    2016-07-01

    The simulation of the chemical stage of radiobiological mechanism may be very helpful in studying the radiobiological effect of ionizing radiation when the water radical clusters formed by the densely ionizing ends of primary or secondary charged particle may form DSBs damaging DNA molecules in living cells. It is possible to study not only the efficiency of individual radicals but also the influence of other species or radiomodifiers (mainly oxygen) being present in water medium during irradiation. The mathematical model based on Continuous Petri nets (proposed by us recently) will be described. It makes it possible to analyze two main processes running at the same time: chemical radical reactions and the diffusion of radical clusters formed during energy transfer. One may study the time change of radical concentrations due to the chemical reactions running during diffusion process. Some orientation results concerning the efficiency of individual radicals in DSB formation (in the case of Co60 radiation) will be presented; the influence of oxygen present in water medium during irradiation will be shown, too.

  4. Operation and Maintenance of the National Radiobiology Archives

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Anthony C. James; Stacey L. McCord

    2012-03-07

    The National Radiobiology Archives (NRA) are an archival program, started in 1989, to collect, organize and maintain data, laboratory notebooks, and animal tissue specimens from government (Department of Energy and its predecessor agencies) sponsored radiobiology life-span animal studies. These unique records, histopathology slides and paraffin embedded tissue blocks are maintained in a central facility and are available for further research study. The materials include electronic and paper records for each of more than 6,000 life-span-observations on dogs as well as details of major studies involving nearly 30,000 mice. Although these studies were performed over many years and at different laboratories with differing data management systems, the NRA has translated them into a standardized set of relational database tables. These can be distributed to interested individuals on written request. Specific Aims are: (1) To Maintain the Archive of Written Records from the Animal Experiments - The USTUR continued to maintain the NRA archives which consist of approximately 175 storage boxes containing laboratory notebooks, animal exposure records, animal pathologic records, and radiographs. These were stored in a 6,000 square foot leased facility in Richland, WA. Additionally, through a collaboration with Pacific Northwest National Laboratory's (PNNL) Low Dose Program, many of these records were scanned into digital files. These totaled 34 GB of data, which are saved in 2,407 separate PDF files that are organized by box number and animal identification number. (2) To Maintain the Archive of Animal Tissues at Washington State University - The USTUR continued to house the NRA dog tissue collection in the leased facility. The NRA tissue collection consisted of pathology slides and tissue blocks. Approximately 25% of the laboratory facility was dedicated to the storage of the NRA materials. (3) To Organize the Datasets of These Animals in the Context of Other Datasets so

  5. Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

    CERN Document Server

    Boissonnat, G; Balanzat, E; Boumard, F; Carniol, B; Colin, J; Cussol, D; Etasse, D; Fontbonne, C; Frelin, A -M; Hommet, J; Peronnel, J; Salvador, S

    2016-01-01

    Currently, radiobiology experiments using heavy ions at GANIL(Grand Acc\\'el\\'erateur National d'Ions Lourds) are conducted under the supervision of the CIMAP (Center for research on Ions, MAterials and Photonics). In this context, a new beam monitoring equipment named DOSION has been developed. It allows to perform measurements of accurate fluence and dose maps in near real time for each biological sample irradiated. In this paper, we present the detection system, its design, performances, calibration protocol and measurements performed during radiobiology experiments. This setup is currently available for any radiobiology experiments if one wishes to correlate one's own sample analysis to state of the art dosimetric references.

  6. Studies in the radiobiology of osteoradionecrosis and their clinical significance

    Energy Technology Data Exchange (ETDEWEB)

    Marx, R.E.; Johnson, R.P.

    1987-10-01

    The radiobiology of osteoradionecrosis is a complex of cellular death and cellular functional impairments from radiation energy transfers. Four studies of irradiated patients and a data base from 536 patients with osteoradionecrosis revealed separate pathophysiologic conditions for osteoradionecrosis induced by early trauma, osteoradionecrosis induced by late trauma, and spontaneous osteoradionecrosis. A large body of data suggested useful clinical guidelines for the management of irradiated patients. The guidelines, in part, include a recommendation for deferring radiation treatment for 21 days after tissue wounding, if possible; a relative contraindication to wounding tissue during a radiation course; a recommendation for the use of hyperbaric oxygen before wounding; and a strong recommendation to provide comprehensive dental care to the irradiated patient.

  7. Method for validating radiobiological samples using a linear accelerator

    International Nuclear Information System (INIS)

    There is an immediate need for rapid triage of the population in case of a large scale exposure to ionizing radiation. Knowing the dose absorbed by the body will allow clinicians to administer medical treatment for the best chance of recovery for the victim. In addition, today's radiotherapy treatment could benefit from additional information regarding the patient's sensitivity to radiation before starting the treatment. As of today, there is no system in place to respond to this demand. This paper will describe specific procedures to mimic the effects of human exposure to ionizing radiation creating the tools for optimization of administered radiation dosimetry for radiotherapy and/or to estimate the doses of radiation received accidentally during a radiation event that could pose a danger to the public. In order to obtain irradiated biological samples to study ionizing radiation absorbed by the body, we performed ex-vivo irradiation of human blood samples using the linear accelerator (LINAC). The LINAC was implemented and calibrated for irradiating human whole blood samples. To test the calibration, a 2 Gy test run was successfully performed on a tube filled with water with an accuracy of 3% in dose distribution. To validate our technique the blood samples were ex-vivo irradiated and the results were analyzed using a gene expression assay to follow the effect of the ionizing irradiation by characterizing dose responsive biomarkers from radiobiological assays. The response of 5 genes was monitored resulting in expression increase with the dose of radiation received. The blood samples treated with the LINAC can provide effective irradiated blood samples suitable for molecular profiling to validate radiobiological measurements via the gene-expression based biodosimetry tools. (orig.)

  8. A statistical method for descriminating between alternative radiobiological models

    International Nuclear Information System (INIS)

    Radiobiological models assist understanding of the development of radiation damage, and may provide a basis for extrapolating dose-effect curves from high to low dose regions. Many models have been proposed such as multitarget and its modifications, enzymatic models, and those with a quadratic dose response relationship (i.e. αD + βD2 forms). It is difficult to distinguish between these because the statistical techniques used are almost always limited, in that one method can rarely be applied to the whole range of models. A general statistical procedure for parameter estimation (Maximum Liklihood Method) has been found applicable to a wide range of radiobiological models. The curve parameters are estimated using a computerised search that continues until the most likely set of values to fit the data is obtained. When the search is complete two procedures are carried out. First a goodness of fit test is applied which examines the applicability of an individual model to the data. Secondly an index is derived which provides an indication of the adequacy of any model compared with alternative models. Thus the models may be ranked according to how well they fit the data. For example, with one set of data, multitarget types were found to be more suitable than quadratic types (αD + βD2). This method should be of assitance is evaluating various models. It may also be profitably applied to selection of the most appropriate model to use, when it is necessary to extrapolate from high to low doses

  9. The radiobiology/radiation protection interface in healthcare

    International Nuclear Information System (INIS)

    The current knowledge of radiation effects is reviewed and implications for its application in healthcare considered. The 21st L H Gray conference gathered leading experts in radiobiology, radiation epidemiology, radiation effect modelling, and the application of radiation in medicine to provide an overview of the subject. The latest radiobiology research in non-targeted effects such as genomic instability and the bystander effect challenge the old models, but the implications for health effects on humans are uncertain. Adaptive responses to external stresses, of which radiation is one, have been demonstrated in cells and animal models, but it is not known how these might modify human dose-effect relationships. Epidemiological evidence from the Japanese A-bomb survivors provides strong evidence that there is a linear relationship between the excess risk of cancer and organ dose that extends from about 50 mSv up to 2.5 Sv, and results from pooled data for multiple epidemiological studies indicate that risks extend down to doses of 20 mSv. Thus linear extrapolation of the A-bomb dose-effect data provides an appropriate basis for radiological protection standards at the present time. Risks from higher dose diagnostic procedures fall within the range in which health effects can be demonstrated. There is therefore reason for concern about the rise in the number of computed tomography (CT) scans performed in many countries, and in particular the use of CT for screening of asymptomatic individuals. New radiotherapy techniques allow high dose radiation fields to be conformed more effectively to target volumes, and reduce doses to critical organs, but they tend to give a higher and more uniform dose to the whole body which may increase the risk of second cancer. It is important that radiation protection practitioners keep abreast of developments in understanding of radiation effects and advise the medical community about the implications of fundamental research when

  10. Strategies to improve the efficacy of radioimmunotherapy: Radiobiologic aspects

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate methods of improving the therapeutic index (dose to tumor/dose to normal organs) and, hence, the efficacy of radioimmunotherapy (RIT). One method investigated was to increase the biologic response for a given radiation dose to tumor. To enhance the biologic efficacy of the dose, initial studies focused on first understanding the radiobiology of RIT irradiation and determining what role factors, such as radiation repair, repopulation, and redistribution, play in determining RIT response. In vitro studies using 4 colon carcinoma cell lines have compared the radiobiologic efficacy of low dose-rate irradiation delivered by Yttrium-90 (Y-90) with conventional high dose-rate external beam irradiation (XRT). Results suggested that one factor which determined a cell's sensitivity to Y-90 irradiation was its ability to repair radiation sublethal damage. In vivo studies demonstrated that those cell lines which were more sensitive to Y-90 irradiation in vitro were also more sensitive to RIT in vivo. For a more radioresistant line, WiDr, RIT was approximately two-fold less effective than an equivalent dose of single fraction XRT, while for a more radiosensitive line, LS174T, RIT was approximately as effective as an equivalent dose of single fraction XRT. Therefore, a tumor's response to RIT in vivo appeared to be, in part, dependent on the tumor cell's ability to repair radiation damage. Finally, studies investigated strategies at enhancing the biologic efficacy of RIT irradiation by combining RIT with chemotherapy agents that can potentially inhibit radiation repair. Agents, such as 5-fluorouracil, appeared to be synergistic with RIT irradiation n vitro and may therefore prove promising in improving the therapeutic index of RIT

  11. Knowledge evolution on effects of ionizing radiations on living being. New prospects of radiobiological researches

    International Nuclear Information System (INIS)

    The knowledge increase of all the steps going from the material radiation interaction to the risk evaluation, prevention and irradiation consequences treatment leads to new prospects in radiobiology research, such as the low doses effects. (A.B.)

  12. Bistable Head Positioning Arm Latch

    Science.gov (United States)

    Wasson, Ken; Endo, Juro; Mita, Masahiro; Abelein, Nathan

    A simple, low cost, yet effective device has been developed for immobilizing the head-arm assembly in a disk drive or similar mechanism during power-off conditions. The latching scheme also provides a consistent means of releasing the head-arm assembly from the immobilized position upon power up of the disk drive. The latch uses no electrical power in either immobilized or released state. This design is immune to extreme torque and linear shock forces applied to the disk drive case. The latch system can use the energy stored in the spinning disks to drive the head-arm assembly toward a safe position while simultaneously arming the latch mechanism to secure the head-arm assembly in the safe position upon arrival. A low energy five msec pulse of current drives the latch from one state to the other. Solenoids as presently used in latch mechanisms are bulky, expensive, have variable force characteristics, and often generate contaminants. The latch described in this paper is expected to replace such solenoids. It may also replace small magnet latches, which have limited latch force and apply unwanted torque to a proximate head positioning arm.

  13. Press breakfast, radiobiology stakes: an European context, Thursday 25 March 2004

    International Nuclear Information System (INIS)

    The radiobiology endeavours to know the ionizing radiations effects on living systems, particular at low doses exposures. The researches in this area contribute to the elaboration of international regulation on nuclear industry. The individual radiosensitivity is an other aspect of the research in radiobiology. These studies should allow the establishing of radiation protection standards founded on a direct approach and an individual estimation of the level of acceptable dose. (N.C.)

  14. Tan Zheng,s On the Problems of Army Political Work and the Maturity and Development of Party Building Theory for the Armed Forces%谭政《关于军队政治工作问题》的报告与军队党建理论成熟与发展

    Institute of Scientific and Technical Information of China (English)

    杨忠虎

    2014-01-01

    Delegated by the Party Central and Mao Zedong, Tan Zheng made the report On the Problems of Ar-my Political Work at the Northwestern Senior Cadres, Meeting to elaborate a series of theoretical principles for party building in the armed forces. The report expounded the status and effects of party building in the armed forces, clarified the fundamental tasks of party building in the armed forces, revealed the essential relationship between party building and military building in the armed forces, raised a series of principles for party ideological building in the armed forces, and proposed important arguments such as necessity of scientification and continuous institu-tional innovation for party building in armed forces. The Tan Zheng Report is an important part of Mao Zedong Thought on party building, a programmatic document to guide party building in the armed forces, and still has e-normous guiding significance for party building in the armed forces under the new historical situations.%谭政受党中央、毛泽东同志的委托,在西北局高干会上做的《关于军队政治工作问题》的报告,阐述了军队党的建设一系列重大理论原则:阐明了军队党的建设的地位作用,明确了军队党的建设的根本任务,揭示了军队党的建设与军队建设的本质联系,提出了军队党的思想建设的一系列原则,提出了军队党的建设要科学化和不断进行制度创新等重要观点。《谭政报告》是毛泽东建党思想的重要组成部分,是指导军队党的建设的纲领性文件,对新的历史条件下军队党建仍具有巨大的指导意义。

  15. 武警部队机关干部工作精力与体质要求分析%Analysis of the Request of Working Energy and Physical Quality of Office Cadres in Armed Police Force

    Institute of Scientific and Technical Information of China (English)

    倪红军

    2012-01-01

    The paper analyzed the biological phenomena of the working staff in the management office of Armed Police Force through the form of questionnaire and test, detailed expounded the physical and mental request of the brain work and pointed out that a healthy body was an important component of new - style military working talents and work - out is a process from quantitative change to qualitative change of human functions.%运用问卷法和测试法对武警部队机关工作人员身体生物现象进行分析,详细论述了脑力工作对人体生理、心理的要求。指出:健康的体魄是新型部队机关人才构成的要素,体育锻炼是人体机能改善由量变到质变的过程。

  16. Evaluation of radiobiological effects in 3 distinct biological models

    International Nuclear Information System (INIS)

    Full text of publication follows. The present work aims at sharing the process of development of advanced biological models to study radiobiological effects. Recognizing several known limitations and difficulties of the current monolayer cellular models, as well as the increasing difficulties to use advanced biological models, our group has been developing advanced biological alternative models, namely three-dimensional cell cultures and a less explored animal model (the Zebra fish - Danio rerio - which allows the access to inter-generational data, while characterized by a great genetic homology towards the humans). These 3 models (monolayer cellular model, three-dimensional cell cultures and zebra fish) were externally irradiated with 100 mGy, 500 mGy or 1 Gy. The consequences of that irradiation were studied using cellular and molecular tests. Our previous experimental studies with 100 mGy external gamma irradiation of HepG2 monolayer cells showed a slight increase in the proliferation rate 24 h, 48 h and 72 h post irradiation. These results also pointed into the presence of certain bystander effects 72 h post irradiation, constituting the starting point for the need of a more accurate analysis realized with this work. At this stage, we continue focused on the acute biological effects. Obtained results, namely MTT and clonogenic assays for evaluating cellular metabolic activity and proliferation in the in vitro models, as well as proteomics for the evaluation of in vivo effects will be presented, discussed and explained. Several hypotheses will be presented and defended based on the facts previously demonstrated. This work aims at sharing the actual state and the results already available from this medium-term project, building the proof of the added value on applying these advanced models, while demonstrating the strongest and weakest points from all of them (so allowing the comparison between them and to base the subsequent choice for research groups starting

  17. The ROC Armed Forces and Civil Society in Natural Disaster Relief Operations—A Deepening Cooperation and the Establishment of Sound Disaster Relief System

    OpenAIRE

    Hsieh, Yih-Shiun

    2012-01-01

    The primary purpose of the design and build of military forces is to deal with traditional security threats, especially the military invasion from other country. Nowadays, such thinking is not enough for facing current non-traditional challenges caused by climate changes, such as volcanic eruptions, earthquakes, tsunamis, as well as floods and landslides. Owing to the rapid deployment and effectiveness of military organization in case of crisis-whether manmade or natural, so any government of...

  18. Lever arm dysfunction in cerebral palsy gait

    OpenAIRE

    Theologis, Tim

    2013-01-01

    Skeletal structures act as lever arms during walking. Muscle activity and the ground reaction against gravity exert forces on the skeleton, which generate torque (moments) around joints. These lead to the sequence of movements which form normal human gait. Skeletal deformities in cerebral palsy (CP) affect the function of bones as lever arms and compromise gait. Lever arm dysfunction should be carefully considered when contemplating treatment to improve gait in children with CP.

  19. Novel Radiobiological Gamma Index for Evaluation of 3-Dimensional Predicted Dose Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Sumida, Iori, E-mail: sumida@radonc.med.osaka-u.ac.jp [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Yamaguchi, Hajime; Kizaki, Hisao; Aboshi, Keiko; Tsujii, Mari; Yoshikawa, Nobuhiko; Yamada, Yuji [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan); Suzuki, Osamu; Seo, Yuji [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Isohashi, Fumiaki [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan); Yoshioka, Yasuo [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Ogawa, Kazuhiko [Department of Radiation Oncology, NTT West Osaka Hospital, Osaka (Japan)

    2015-07-15

    Purpose: To propose a gamma index-based dose evaluation index that integrates the radiobiological parameters of tumor control (TCP) and normal tissue complication probabilities (NTCP). Methods and Materials: Fifteen prostate and head and neck (H&N) cancer patients received intensity modulated radiation therapy. Before treatment, patient-specific quality assurance was conducted via beam-by-beam analysis, and beam-specific dose error distributions were generated. The predicted 3-dimensional (3D) dose distribution was calculated by back-projection of relative dose error distribution per beam. A 3D gamma analysis of different organs (prostate: clinical [CTV] and planned target volumes [PTV], rectum, bladder, femoral heads; H&N: gross tumor volume [GTV], CTV, spinal cord, brain stem, both parotids) was performed using predicted and planned dose distributions under 2%/2 mm tolerance and physical gamma passing rate was calculated. TCP and NTCP values were calculated for voxels with physical gamma indices (PGI) >1. We propose a new radiobiological gamma index (RGI) to quantify the radiobiological effects of TCP and NTCP and calculate radiobiological gamma passing rates. Results: The mean RGI gamma passing rates for prostate cases were significantly different compared with those of PGI (P<.03–.001). The mean RGI gamma passing rates for H&N cases (except for GTV) were significantly different compared with those of PGI (P<.001). Differences in gamma passing rates between PGI and RGI were due to dose differences between the planned and predicted dose distributions. Radiobiological gamma distribution was visualized to identify areas where the dose was radiobiologically important. Conclusions: RGI was proposed to integrate radiobiological effects into PGI. This index would assist physicians and medical physicists not only in physical evaluations of treatment delivery accuracy, but also in clinical evaluations of predicted dose distribution.

  20. Fisheries Radiobiology and the Discharge of Radioactive Wastes

    International Nuclear Information System (INIS)

    In the United Kingdom authorizations to discharge radioactive wastes are granted by the Minister of Housing and Local Government, the Minister of Agriculture, Fisheries and Food, and by the Secretary of State for Scotland. The hazards arising from contamination of aquatic animals and plants concern the Department of Fisheries ; before authorizations to discharge liquid wastes have been given, the Department has made independent forecasts of permissible levels of discharge based on extensive studies carried out in its research vessels and radiobiological laboratory: for example, where fish have been affected this has meant studies of fish populations and fish migration: uptake of radioactivity by fish : public consumption of fish : commercial distribution of affected fish: L.D.50: effects of radiation on tissue, etc. In the course of such work there has been close consultation with the Atomic Energy Authority, and agreement with the Atomic Energy Authority about the safety factor to be incorporated during the first two years of discharge. During these two years, monitoring data collected by the Atomic Energy Authority and the Ministry of Agriculture, Fisheries and Food enable checks and revisions of the original estimates to be made, and at the end of that time formal authorizations, based on operating experience, are issued. (author)

  1. Feasibility of BNCT radiobiological experiments at the HYTHOR facility

    Science.gov (United States)

    Esposito, J.; Ceballos, C.; Soncin, M.; Fabris, C.; Friso, E.; Moro, D.; Colautti, P.; Jori, G.; Rosi, G.; Nava, E.

    2008-06-01

    HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in vivo radiobiological studies. In HYTHOR irradiation cavity, 1-6 mice can be simultaneously irradiated to study skin melanoma treatments with the BNCT (boron neutron capture therapy). The therapeutic effects of HYTHOR radiation field on mouse melanoma has been studied as a preliminary investigation before studying the tumour local control due to boron neutron capture effect after boronated molecule injection. The method to properly irradiate small animals has been precisely defined. Results show that HYTHOR radiation field is by itself effective in reducing the tumour-growth rate. This finding has to be taken into account in studying the effectiveness of new 10B carriers. A method to properly measure the reduction of the tumour-growth rate is reported and discussed.

  2. [Radiobiological analysis of cancerogenic risk values in radioepidemiological investigations].

    Science.gov (United States)

    Rozhdestvenskiĭ, L M

    2008-01-01

    The aim of the present article consisted in critical analysis of the epidemiological approach to radiocancerogenic risk estimation in region of low level radiation (LLR). The estimation is making by means of mathematician models that ignore a principal difference in biological action of LLR and high level radiation (HLR). The main formal characteristic of LLR action is the presence of a plateau in beginning of a dose-effect curve of radiogenic risk. It may be argued by the following positions: repeating the plateau-phenomenon on various radiobiological effects, in different tests and bioobjects, first; a paradoxical trend of reciprocal ERR/Sv increasing regarding dose decreasing in region of plateau, second, and third, the increasing of the curvature in dose-effect curve beginning. The presence of a plateau is associated with the presence of a real radiogenic risk threshold. Besides, the analysis of processes influencing significantly the dynamics of initial radiation injury of biologically important macromolecules showed the preference in region of LLR those, decreasing/eliminating genome damages. There is follows from mentioned above a necessity to evaluate radiogenic risks in LLR region separately from HLR region. PMID:18825986

  3. Radiobiological study by using laser-driven proton beams

    Science.gov (United States)

    Yogo, A.; Sato, K.; Nishikino, M.; Mori, M.; Teshima, T.; Numasaki, H.; Murakami, M.; Demizu, Y.; Akagi, S.; Nagayama, S.; Ogura, K.; Sagisaka, A.; Orimo, S.; Nishiuchi, M.; Pirozhkov, A. S.; Ikegami, M.; Tampo, M.; Sakaki, H.; Suzuki, M.; Daito, I.; Oishi, Y.; Sugiyama, H.; Kiriyama, H.; Okada, H.; Kanazawa, S.; Kondo, S.; Shimomura, T.; Nakai, Y.; Tanoue, M.; Sugiyama, H.; Sasao, H.; Wakai, D.; Kawachi, T.; Nishimura, H.; Bolton, P. R.; Daido, H.

    2009-07-01

    Particle acceleration driven by high-intensity laser systems is widely attracting interest as a potential alternative to conventional ion acceleration, including ion accelerator applications to tumor therapy. Recent works have shown that a high intensity laser pulse can produce single proton bunches of a high current and a short pulse duration. This unique feature of laser-ion acceleration can lead to progress in the development of novel ion sources. However, there has been no experimental study of the biological effects of laser-driven ion beams. We describe in this report the first demonstrated irradiation effect of laser-accelerated protons on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. The laser-driven ion beam is apotential excitation source for time-resolved determination of hydroxyl (OH) radical yield, which will explore relationship between the fundamental chemical reactions of radiation effects and consequent biological processes.

  4. Dosimetry for radiobiological experiments using energetic heavy ions

    International Nuclear Information System (INIS)

    The availability of the Bevalac facility of energetic heavy ions with range greater than the size of small mammals makes possible the determination of the biological effects of relatively well defined high LET, whole body irradiation. With the increasing application of high-energy heavy ions in radiobiology there is a corresponding need to develop reliable techniques of both relative and absolute absorbed dose measurement. This paper describes dosimetry studies by the Health Physics Department of the Lawrence Berkeley Laboratory with activation detectors, ionization chambers, nuclear emulsion, thermoluminescent dosimeters and X-ray film. The application of these techniques to an experiment designed to study the leukemogenic effect of the whole-body irradiation of mice by 250 MeV/amu carbon ions is briefly described. Values of absorbed dose in tissue, obtained during this experiment, with a nitrogen filled ionization chamber and 7LiF thermoluminescent dosimeters are compared and shown to be in good agreement. As a result of this work a value for the average energy to produce an ion pair (W) in nitrogen by 250 MeV/amu 6+C ions of 37 +- eV was determined. Values of the efficiency of 7LiF relative to 60Co γ-rays for ions with dE/dx in the range 110-260 MeV g-1 cm2 are reported

  5. Amchitka Radiobiological Program progress report, January 1979-December 1979

    International Nuclear Information System (INIS)

    The objective of the Amchitka Radiobiological Program for the period 1970-1979 was to determine the extent of radionuclide contamination from world-wide atmospheric fallout and from the detonation of three underground nuclear blasts on Amchitka Island. The objective is achieved, by the collection and radiological analyses of biological and environmental samples and by background radiation measurements. Leakage of radionuclides from the underground sites of the Amchitka nuclear detonations would be suspected if the contamination was significntly greater than would be expected from world fallout. An account of the program from July 1970 to December 1978 has been given in nine previous reports from the Laboratory of Radiation Ecology to the Nevada Operations Office of the US Department of Energy. This report is an account of the program for calendar year 1979. The results of analyses of the samples collected in 1979 lead to the same conclusions as in previous years; i.e., there is no evidence that the radionuclide contamination at Amchitka Island is greater than would be expected from world fallout except for a slight contamination of the Long Shot Mud Pits with tritium

  6. The search for mass graves of the soldiers of the National Armed Forces murdered in September 1946 in the Opole region of Poland – results of forensic medical examination

    Directory of Open Access Journals (Sweden)

    Łukasz Szleszkowski

    2015-05-01

    Full Text Available The aim of the study is the identification and forensic-medical and anthropological evaluation of the remains of soldiers of the National Armed Forces murdered by the secret police in September 1946 in the Opole region. The remains were located during the search for mass graves of victims of the Communist regime carried out by the Institute of National Remembrance (IPN. Material and methods: In June 2012 and April 2013, in the area of the Hubertus clearing between the villages of Barut and Dąbrówka, 41 human bone fragments were revealed in the course of archaeological works carried with use of the open pit method at the probable site of the liquidation of one of the groups of soldiers from the unit of Captain Henryk Flame, aka “Bartek”. In the vicinity of the ruins of the former Scharfenberg manor, in a forest of the Łambinowice commune, a mass grave was discovered containing the remains of at least 25 individuals, mostly young men. The grave was damaged and bore traces of subsequent interference. The forensic-medical-anthropological examination procedures were carried out, the biological profile of the victims evaluated, the minimum number of individuals (MNI determined and the injuries interpreted. Results : A portion of the remains discovered near the village of Barut bore traces of trauma associated with a great force. On the remains from the mass grave in the Łambinowice commune, numerous traces of injuries of the perimortem trauma nature were disclosed, including gunshot damage, both within the skulls and in post-cranial skeletons. Conclusions : The activity of the Institute of National Remembrance led to the confirmation of archival data regarding the site of liquidation of one of the partisan groups of the National Armed Forces in the vicinity of the village of Barut in the Opole region. The research did not allow unambiguous determination of the origin of remains discovered in the mass grave in the Łambinowice commune. The

  7. The significance of the choice of radiobiological (NTCP) models in treatment plan objective functions

    International Nuclear Information System (INIS)

    Full text: A Clinician's discrimination between radiation therapy treatment plans is traditionally a subjective process, based on experience and existing protocols. A more objective and quantitative approach to distinguish between treatment plans is to use radiobiological or dosimetric objective functions, based on radiobiological or dosimetric models. The efficacy of models is not well understood, nor is the correlation of the rank of plans resulting from the use of models compared to the traditional subjective approach. One such radiobiological model is the Normal Tissue Complication Probability (NTCP). Dosimetric models or indicators are more accepted in clinical practice. In this study, three radiobiological models, Lyman NTCP, critical volume NTCP and relative seriality NTCP, and three dosimetric models, Mean Lung Dose (MLD) and the Lung volumes irradiated at lOGy (V|0) and 20Gy (V20), were used to rank a series of treatment plans using, harm to normal (Lung) tissue as the objective criterion. None of the models considered in this study showed consistent correlation with the Radiation Oncologists plan ranking. If radiobiological or dosimetric models are to be used in objective functions for lung treatments, based on this study it is recommended that the Lyman NTCP model be used because it will provide most consistency with traditional clinician ranking.

  8. Effects of medical intervention on low back pain among the armed police forces officers and soldiers%医学干预对武警官兵下腰痛的影响

    Institute of Scientific and Technical Information of China (English)

    纪慧茹; 徐继培; 黄菲; 王策; 汪曙燕; 张倩

    2012-01-01

    目的 探讨医学干预对武警部队官兵下腰痛发生情况的影响.方法 随机整群抽样,将武警 部队的两个大队分为两组.一个大队作为干预组,训练过程中采取"教授腰背部预防保护知识,优化训练 措施与方案,进行科学施训,加强心理辅导,强化腰背肌锻炼,受伤后及时诊治"等措施干预;另一大队按 照以往常规方法进行训练,不加任何干预措施,作为对照组.观察12个月内两组官兵的下腰痛的发生情 况.结果 干预组的下腰痛的发生率为10.18%,显著低于对照组(16.13%,P =0.0001)干预组的急性腰扭伤 发生率为3.64%,低于对照组5.91%(χ2=5.4173,P=0.0199;)干预组的急性腰扭伤和腰肌劳损发生率 4.78%,显著低于对照组(7.49%,χ2=6.0879,P=0.0136).结论 实施医学干预可有效降低武警官兵下腰 痛的发生率.%Objective To investigate the effects of medical intervention on the occurrence of low back pain among the armed police forces officers and soldiers . Methods By random cluster sampling, 948 armed police forces officers and soldier, all males, aged 18~32, were selected to undergo conventional training (control group), and 962 age-, sex-, constitution, and length of military service-matched officers and soldier received additional intervention program, including health education, optimization of the training plan and measures, psychological counseling, strengthening of exercising the muscle of low back, and treating the injury of low back in time (intervention group). One year later the incidence rates of low back pain, acute of lumbar sprain, and chronic lumbar muscle strain were analyzed. Results The incidence rate of low back pain of the intervention group was 10.18%, significantly lower than that of the control group(16.13%, P =0.0001). The incidence rate of acute lumbar sprain of the intervention group was 3.64% , , significantly lower than that of the control group (5.91%, X2 = 5.4173, P= 0.0199). . he

  9. Heavy-ion tumor therapy: Physical and radiobiological benefits

    Science.gov (United States)

    Schardt, Dieter; Elsässer, Thilo; Schulz-Ertner, Daniela

    2010-01-01

    High-energy beams of charged nuclear particles (protons and heavier ions) offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon therapy. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum (Bragg peak) near the end of range with a sharp fall-off at the distal edge. Taking full advantage of the well-defined range and the small lateral beam spread, modern scanning beam systems allow delivery of the dose with millimeter precision. In addition, projectiles heavier than protons such as carbon ions exhibit an enhanced biological effectiveness in the Bragg peak region caused by the dense ionization of individual particle tracks resulting in reduced cellular repair. This makes them particularly attractive for the treatment of radio-resistant tumors localized near organs at risk. While tumor therapy with protons is a well-established treatment modality with more than 60 000 patients treated worldwide, the application of heavy ions is so far restricted to a few facilities only. Nevertheless, results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities. This article reviews the progress in heavy-ion therapy, including physical and technical developments, radiobiological studies and models, as well as radiooncological studies. As a result of the promising clinical results obtained with carbon-ion beams in the past ten years at the Heavy Ion Medical Accelerator facility (Japan) and in a pilot project at GSI Darmstadt (Germany), the plans for new clinical centers for heavy-ion or combined proton and heavy-ion therapy have recently received a substantial boost.

  10. Radiobiological basis for setting neutron radiation safety standards

    International Nuclear Information System (INIS)

    Present neutron standards, adopted more than 20 yr ago from a weak radiobiological data base, have been in doubt for a number of years and are currently under challenge. Moreover, recent dosimetric re-evaluations indicate that Hiroshima neutron doses may have been much lower than previously thought, suggesting that direct data for neutron-induced cancer in humans may in fact not be available. These recent developments make it urgent to determine the extent to which neutron cancer risk in man can be estimated from data that are available. Two approaches are proposed here that are anchored in particularly robust epidemiological and experimental data and appear most likely to provide reliable estimates of neutron cancer risk in man. The first approach uses gamma-ray dose-response relationships for human carcinogenesis, available from Nagasaki (Hiroshima data are also considered), together with highly characterized neutron and gamma-ray data for human cytogenetics. When tested against relevant experimental data, this approach either adequately predicts or somewhat overestimates neutron tumorigenesis (and mutagenesis) in animals. The second approach also uses the Nagasaki gamma-ray cancer data, but together with neutron RBEs from animal tumorigenesis studies. Both approaches give similar results and provide a basis for setting neutron radiation safety standards. They appear to be an improvement over previous approaches, including those that rely on highly uncertain maximum neutron RBEs and unnecessary extrapolations of gamma-ray data to very low doses. Results suggest that, at the presently accepted neutron dose limit of 0.5 rad/yr, the cancer mortality risk to radiation workers is not very different from accidental mortality risks to workers in various nonradiation occupations

  11. SU-E-T-385: 4D Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Fourkal, E; Hossain, M; Veltchev, I; Ma, C; Meyer, J; Horwitz, E [Fox Chase Cancer Center, Philadelphia, PA (United States); Nahum, A [Clatterbridge Centre for Oncology, Bebington (United Kingdom)

    2014-06-01

    Purpose: The linear-quadratic model is the most prevalent model for planning dose fractionation in radiation therapy in the low dose per fraction regimens. However for high-dose fractions, used in SRS/SBRT/HDR treatments the LQ model does not yield accurate predictions, due to neglecting the reduction in the number of sublethal lesions as a result of their conversion to lethal lesions with subsequent irradiation. Proper accounting for this reduction in the number of sublethally damaged lesions leads to the dependence of the survival fraction on the temporal structure of the dose. The main objective of this work is to show that the functional dependence of the dose rate on time in each voxel is an important additional factor that can significantly influence the TCP. Methods: Two SBRT lung plans have been used to calculate the TCPs for the same patient. One plan is a 3D conformal plan and the other is an IMRT plan. Both plans are normalized so that 99.5% of PTV volume receives the same prescription dose of 50 Gy in 5 fractions. The dose rate in each individual voxel is calculated as a function of treatment time and subsequently used in the calculation of TCP. Results: The calculated TCPs show that shorter delivery times lead to greater TCP, despite all delivery times being short compared to the repair half-time for sublethal lesions. Furthermore, calculated TCP(IMRT) =0.308 for the IMRT plan is smaller than TCP(3D) =0.425 for 3D conformal, even though it shows greater tumor hot spots and equal PTV coverage. The calculated TCPs are considerably lower compared to those based on the LQ model for which TCP=1 for both plans. Conclusion: The functional dependence of the voxel-by-voxel dose rate on time may be an important factor in predicting the treatment outcome and cannot be neglected in radiobiological modeling.

  12. 基层指挥士官胜任特征问卷的初步编制%Formulation of the competency trait scale for noncommissioned officers in Chinese People's Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    刘红; 孙丽云; 王宪利; 许爱萍

    2012-01-01

    Objective To formulate a competency trait scale (CTS) for noncommissioned officers in Chinese People ' s Armed Police Forces and to confirm its reliability and validity. Methods 572 noncommissioned officers were measured using the competency trait scale (CTS). Results Based on item analysis and exploring factor analysis , the scale involved five dimensions : self-control, organization commitment, achievement motivation , communication ability and responsibility. The alpha coefficient of the scale was 0.888, while that of other dimensions was 0.806, 0.750, 0.718, 0.682, and 0.682, respectively. The retest coefficient was 0.825. There was significant difference between ordinary noncommissioned officers and excellent noncommissioned officers in each dimension of CTS. The job performance of noncommissioned officers was positively correlated with self - control, organization commitment, achievement motivation, responsibility and the total score of competency trait. Conclusions CTS is highly reliable and valid as a psychologi -cal tool for noncommissioned officers in Armed Police Forces .%目的 编制符合武警部队基层指挥士官胜任特征的问卷.方法 整群抽取武警某部士官572名,使用自编胜任特征问卷进行评估.结果 根据项目分析、探索性因素分析确定该问卷包含5个维度,分别为自我控制、组织承诺、成就动机、沟通能力及责任心.该问卷的内部一致性信度(α系数)为0.888,各维度α系数分别为:0.806,0.750,0.718,0.682,0.682.重测信度为0.825.普通士官与优秀士官在胜任特征各维度上差异有统计学意义(P<0.05),士官的工作绩效总分与自我控制、组织承诺、成就动机、责任感及胜任特征总分具有较高的正相关(P<0.05).结论 该问卷具有良好的信度和效度,可以作为武警基层指挥士官评估、选拔与培训的心理测量工具.

  13. Mao Zedong' s Experience on the Armed Forces Being Also a Working Team%解放战争后期毛泽东工作队的经验及其启示

    Institute of Scientific and Technical Information of China (English)

    兰洋

    2012-01-01

    解放战争后期,尤其是辽沈、淮海、平津三大战役胜利结束以后,毛泽东审时度势,及时地提出了军队不仅是战斗队而且是工作队,要求军队干部应当学会接收、管理城市和新区工作,对促进当时新解放区干部问题的解决和革命事业的顺利发展起到了巨大的促进作用。在新世纪新阶段,我军要借鉴毛泽东的工作队经验。努力做到突出核心军事能力建设,注重非战争军事行动能力建设,注重培养“学习型”高素质复合型军事人才,为维护国家安全、社会稳定和经济发展作贡献。%In the later stage of War of Liberation,especially after Liaoxi-Shenyang,Huai-Hai and Beiping-Tianjing Campaigns, Mao Zedong, correctly appraising the situations, presented the thinking that the armed forces were not only a fighting team but also a working team,requiring that cadres should learn to take over and manage cities and new areas.That has played an important role in developing the cause of the revolution. In the new era,our armed forces should draw lessons from Mao Zedong's experience on the working team,strive to give prominence to improving the core military capacity, focus on the improvement of their unmilitary capacity, try hard to train "learning-oriented" high-quality composite type personnel, safeguard China's security and contribute to economic and social development.

  14. 某军队医学院校学生性行为与性观念的调查分析%Survey on the sexual behavior and sexual concept of the students of an armed forces medical university

    Institute of Scientific and Technical Information of China (English)

    李庆英; 胡役兰; 刘淑红

    2012-01-01

    [目的]了解军队医学生的性行为和性观念情况,为有针对的实施性教育提供依据.[方法]采用问卷调查的方法,对某军队医学院校542名大学生进行性行为和性观念情况进行调查.[结果]不同性别军校医学生的性行为和性观念情况均存在显著性差异,男性性观念比较开放,对于婚前性行为,只有5.1%的男生表示不能接受,而女生有30.2%持此态度;对于多个性伴侣,91.8%的女学生表示绝对不能接受,男生持此态度的占61.2%;男性性行为发生率为30.8%,显著高于女性3.7%,但是女性主动避孕率高于男性.[结论]军队医学生性行为和性观念与性别有关,男性比女性更为开放.%[Objective] To get the message of sexual behavior and sexual concept of the students of an armed forces medical university, for providing a basis on sexual education in future. [Method] A survey was conducted among 542 students by clustered sampling. [Results] There were significant difference among different sex medical students, the sex concept of boys were more open than girls, there were only 5.1% boys could't accept sex behavior before marriage, while there were 30.2% girls took it for granted; 91.8% girls could't accept many sex companions, whik 61.2% boys hold this attitude .the incidence rate of sex behavior of boys was 30.8%, it was higher than girls too, but the initiative contraception rate was higher than boys. [Conclusions] The sexual behavior and sexual concept of armed forces students are related with sex, male are more open than female.

  15. Design of a Dynamic Arm Support (DAS) for gravity compensation

    NARCIS (Netherlands)

    Kramer, Gijs; Römer, GertWillem R.B.E.; Stuyt, Harry J.A.

    2007-01-01

    The Dynamic Arm Support, or briefly the Das, is a new medical device that serves to compensate for lost arm function of the severely disabled. The target group suffers from insufficient muscle force to move its arms over the usual Range of Motion (RoM). The purpose of the Das is to assist its user d

  16. Single-Ion Microbeam for Applications in Radiobiology: State of the Art

    Institute of Scientific and Technical Information of China (English)

    Hu Zhiwen; Wu Lijun; Yu Zengliang

    2005-01-01

    Single-Ion Microbeam (SIM) is uniquely capable of precisely delivering a predefined number of charged particles (precise doses of radiation) to individual cells or sub-cellular targets in situ. Since the early 1990's, there has been an ever-increasing interest in developing and applying the SIM technique to problems in radiobiology for studies of cell and tissue damaged by ionizing radiations. Potential applications for SIM in radiobiology continues to grow and have been diversified. There are currently more than 14 SIM facilities worldwide, and they have been in a constant state of evolution. This paper reviews the current state of SIM research worldwide and the related pivotal technological developments in the fields of both biophysics and radiobiology.Representative applications and the perspective of SIM are also introduced and discussed.

  17. Development of applicable software containing radiobiological and physical indices to evaluate radiotherapy planning

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seu Ran; Suh, Tae Suk [Dept. of Biomedical Engineering, The Catholic University of Korea, Seoul (Korea, Republic of); Park, Ji Yeon [Molecular Imaging Program at Stanford, Stafnord University, Richmond (United States)

    2014-11-15

    Adaptive radiation therapy (ART) provides more conformal dose distribution to the morphologically and physiologically changed tumor volumes during fractionated radiation therapy (RT). To develop an enhanced treatment plan evaluation tool based on multi-modality imaging which incorporates physical and radiobiological parameters, the software system was developed using MATLAB v.7.10.0499 (The Mathworks, Inc., Natick, MA). The application of plan evaluation can help the user choose more biologically optimal treatment plans and potentially predict treatment outcome more accurately. The radiotherapy planning based on the multi-modality images had more accurate results than that of based on only CT images in both physical and radiobiological perspectives.

  18. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Higmar; Yanez, Elvia; Lopez, Jesus [Centro Estatal de Cancerologia de Durango, Victoria de Durango, Durango (Mexico); ISSSTE General Hospital Dr. Santiago Ramon y Cajal, Victoria de Durango, Durango (Mexico)

    2012-10-23

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerologia de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  19. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    Science.gov (United States)

    Herrera, Higmar; Yañez, Elvia; López, Jesús

    2012-10-01

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerología de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  20. 武警院校多媒体资源库建设的现状及对策%The status quo and countermeasures of multimedia resources library construction in armed police force academies

    Institute of Scientific and Technical Information of China (English)

    何建鹏; 王基生

    2011-01-01

    Based on the survey results of multimedia resources library construction in related academies amongtechnieal staff participating in armed police force educational technology training, the paper tries to identify the main factors affecting and constraining the construction of academic multimedia resources library. It also brings forward some countermeasures and suggestions for multimedia resources construction in order to improve the teaching support of multimedia resources library and provide better services for multimedia-assisted teaching.%通过对参加武警部队教育技术骨干培训的人员进行有关院校多媒体教育资源建设现状的调查,分析了影响和制约多媒体资源库建设的主要因素,提出了对策与建议,以提高多媒体资源库的教学保障能力,更好地为多媒体教学服务.

  1. Centralized Management of Military Health Strengths in Station Armed Forces%驻地部队卫勤力量集中调度管理模式改革

    Institute of Scientific and Technical Information of China (English)

    李曙光; 欧崇阳; 胡其平

    2011-01-01

    The author summarized the existing problems of station armed forces in health service person-nel , materials and equipment. Then, a new mode of health strength management was put forward, which included "integrating resources, centralized management and scientific development" , so as to reinforce the comprehensive effects of all level health institutions, serve the preparedness for emergency military region, complete diversified military operations, and satisfied the medical and health demands.%通过归纳目前驻地部队在卫勤人员、物资装备管理等方面存在的问题,对驻地部队“整合资源、集中调度、科学发展”的卫勤力量调度管理新模式进行探讨,以不断增强部队各级卫生机构建设的综合效益,为服务军事斗争准备、完成多样化军事任务、满足官兵医疗卫生需求提供强有力的支援.

  2. 武警初级指挥院校学员人文素质的培养%Cultivation of Humanistic Quality of Students in Preliminary Command Institutions of Armed Police Force

    Institute of Scientific and Technical Information of China (English)

    李杰; 曲卉

    2009-01-01

    Preliminary command institutions of armed policy force are the important base for cultivating high-quality talents. However, due to a variety of reasons, they are weak in the cultivation of humanistic quality of students. To adapt to the development of the modem teaching, the institutions have to adopt effective measures in course system, classroom teaching, student responsibility, and campus environment so as to enhance humanis-tic quality of students as early as possible.%武警初级指挥院校作为培养武警部队高素质人才的重要基地,由于主客观方面的原因,学员人文素质的培养一直相对较弱.要适应现代教学的发展,武警初级指挥院校必须在课程体系、课堂教学、教员职责、校园环境等多个方面采取有效措施,尽快提高学员的人文素质.

  3. Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm.

    Science.gov (United States)

    Dura-Bernal, Salvador; Zhou, Xianlian; Neymotin, Samuel A; Przekwas, Andrzej; Francis, Joseph T; Lytton, William W

    2015-01-01

    Embedding computational models in the physical world is a critical step towards constraining their behavior and building practical applications. Here we aim to drive a realistic musculoskeletal arm model using a biomimetic cortical spiking model, and make a robot arm reproduce the same trajectories in real time. Our cortical model consisted of a 3-layered cortex, composed of several hundred spiking model-neurons, which display physiologically realistic dynamics. We interconnected the cortical model to a two-joint musculoskeletal model of a human arm, with realistic anatomical and biomechanical properties. The virtual arm received muscle excitations from the neuronal model, and fed back proprioceptive information, forming a closed-loop system. The cortical model was trained using spike timing-dependent reinforcement learning to drive the virtual arm in a 2D reaching task. Limb position was used to simultaneously control a robot arm using an improved network interface. Virtual arm muscle activations responded to motoneuron firing rates, with virtual arm muscles lengths encoded via population coding in the proprioceptive population. After training, the virtual arm performed reaching movements which were smoother and more realistic than those obtained using a simplistic arm model. This system provided access to both spiking network properties and to arm biophysical properties, including muscle forces. The use of a musculoskeletal virtual arm and the improved control system allowed the robot arm to perform movements which were smoother than those reported in our previous paper using a simplistic arm. This work provides a novel approach consisting of bidirectionally connecting a cortical model to a realistic virtual arm, and using the system output to drive a robotic arm in real time. Our techniques are applicable to the future development of brain neuroprosthetic control systems, and may enable enhanced brain-machine interfaces with the possibility for finer control of

  4. Cortical spiking network interfaced with virtual musculoskeletal arm and robotic arm

    Directory of Open Access Journals (Sweden)

    Salvador eDura-Bernal

    2015-11-01

    Full Text Available Embedding computational models in the physical world is a critical step towards constraining their behavior and building practical applications. Here we aim to drive a realistic musculoskeletal arm model using a biomimetic cortical spiking model, and make a robot arm reproduce the same trajectories in real time. Our cortical model consisted of a 3-layered cortex, composed of several hundred spiking model-neurons, which display physiologically realistic dynamics. We interconnected the cortical model to a two-joint musculoskeletal model of a human arm, with realistic anatomical and biomechanical properties. The virtual arm received muscle excitations from the neuronal model, and fed back proprioceptive information, forming a closed-loop system. The cortical model was trained using spike timing-dependent reinforcement learning to drive the virtual arm in a 2D reaching task. Limb position was used to simultaneously control a robot arm using an improved network interface. Virtual arm muscle activations responded to motoneuron firing rates, with virtual arm muscles lengths encoded via population coding in the proprioceptive population. After training, the virtual arm performed reaching movements which were smoother and more realistic than those obtained using a simplistic arm model. This system provided access to both spiking network properties and to arm biophysical properties, including muscle forces. The use of a musculoskeletal virtual arm and the improved control system allowed the robot arm to perform movements which were smoother than those reported in our previous paper using a simplistic arm.This work provides a novel approach consisting of bidirectionally connecting a cortical model to a realistic virtual arm, and using the system output to drive a robotic arm in real time. Our techniques are applicable to the future development of brain neuro-prosthetic control systems, and may enable enhanced brain-machine interfaces with the possibility

  5. Skin carcinomas: Radiobiological principles, radiotherapeutic techniques and clinical management

    International Nuclear Information System (INIS)

    Purpose/Objective: The course will be divided into three major topics: (1) Review of radiobiological principles as they apply to the radiotherapeutic management of skin carcinomas; (2) review of radiotherapeutic techniques including beam qualities, beam collimation, tissue dose profiles, and the relative indications of external beam irradiation vs. brachytherapy; (3) comprehensive review of the tumor biology of skin malignancies, including malignant melanoma, and of the relative indications for radiotherapeutic and/or surgical management. (1) Review of critical data which have led to currently applied principles of time-dose-volume concepts in the radiotherapeutic management of skin carcinomas. Emphasis will be placed on the relative importance of fraction size and overall treatment time on tumor control probability and acute and late normal tissue toxicity. (2) Considering that radiotherapy in the management of skin carcinomas is often used to minimize patient disfiguration and to preserve critical body functions (e.g. eye lids) the technical aspects of radiotherapy delivery are most critical. Careful evaluation of the extent of the lesions including evaluation of their depth of invasion will determine the quality of the radiation beams, orthovoltage and low energy electrons being the most useful. Beam harding for orthovoltage beams and secondary and tertiary (skin) collimation of appropriate electron beams are critical. For more extensive and deeply invasive lesions contour-shaping through customized bolus material is essential. Equally important is the familiarity with custom shielding of critical structures, such as eyes, ears, oral cavity and central nervous system structures. Brachytherapy applications in the treatment of skin carcinomas is limited but should be considered when implants with high dose uniformity can be constructed. (3) The discussion of clinical management will start with a discussion of properties and routes of spread of the diverse

  6. Skin carcinomas: radiobiological principles, radiotherapeutic techniques and clinical management

    International Nuclear Information System (INIS)

    Purpose/Objective: The course will be divided into three major topics: (1) Review of radiobiological principles as they apply to the radiotherapeutic management of skin carcinomas; (2) review of radiotherapeutic techniques including beam qualities, beam collimation, tissue dose profiles, and the relative indications of external beam irradiation vs. brachytherapy; (3) comprehensive review of the tumor biology of skin malignancies, including malignant melanoma, and of the relative indications for radiotherapeutic and/or surgical management. (1) Review of critical data which have lead to currently applied principles of time-dose-volume concepts in the radiotherapeutic management of skin carcinomas. Emphasis will be placed on the relative importance of fraction size and overall treatment time on tumor control probability and acute and late normal tissue toxicity. (2) Considering that radiotherapy in the management of skin carcinomas is often used to minimize patient disfiguration and to preserve critical body functions (e.g. eye lids) the technical aspects of radiotherapy delivery are most critical. Careful evaluation of the extent of the lesions including evaluation of their depth of invasion will determine the quality of the radiation beams, orthovoltage and low energy electrons being the most useful. Beam harding for orthovoltage beams and secondary and tertiary (skin) collimation of appropriate electron beams are critical. For more extensive and deeply invasive lesions contour-shaping through customized bolus material is essential. Equally important is the familiarity with custom shielding of critical structures, such as eyes, ears, oral cavity and central nervous system structures. Brachytherapy applications in the treatment of skin carcinomas is limited but should be considered when implants with high dose uniformity can be constructed. (3) The discussion of clinical management will start with a discussion of tumor biological properties of the diverse malignant

  7. A community call for a dedicated radiobiological research facility to support particle beam cancer therapy

    DEFF Research Database (Denmark)

    Holzscheiter, Michael H.; Bassler, Niels; Dosanjh, Manjit;

    2012-01-01

    Recently more than one hundred researchers followed an invitation to a brainstorming meeting on the topic of a future dedicated radio-biological and radio-physical research center. 100 more joint the meeting via webcast. After a day of presentations and discussions it was clear, that an urgent need...

  8. Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981

    International Nuclear Information System (INIS)

    Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once

  9. Experimental radiotherapy and clinical radiobiology. Vol. 8, special issue 1. Proceedings

    International Nuclear Information System (INIS)

    The publication contains the abstracts of all papers and posters presented at the symposium. The headings were as follows: Radiobiology of the lung, mediation of radiation damage in the lung, clinical studies, future clinical directions, as well as documentation and management. (MG)

  10. Arms control: misplaced focus

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, W.A.; Derber, C.

    1986-03-01

    Most of the nuclear debate consists of arguments about which weapons systems should be built, controlled, canceled, frozen, or retired. Short of virtually complete, multilateral nuclear disarmament, however, no change in the pace, balance, or even the direction of the arms race can make much difference in the risk of nuclear war, the damage should one occur, or the division of international political power. This includes Star Wars, the nuclear freeze, and even large cuts in or stabilization of offensive nuclear arsenals. A better starting point for nuclear politics would be the insight that nuclear weapons have completely changed the logic of power as it has been handed down through the ages. Military force, perfected to its highest level, has invalidated itself - for in a nuclearized world, any resort to force by a nuclear power risks escalation to its ultimate level, and thus to oblivion for all. Trying to rationalize and control the ultimate force is far less realistic and important than limiting the provocation of conflict and the use of force at lower, non-nuclear levels - by the United States, it clients, and, to the extent possible, its adversaries. 13 references.

  11. Analysis of Low Back Pain and Health Education of Chinese People's Armed Police Forces%武警官兵下腰痛的调查分析及健康教育

    Institute of Scientific and Technical Information of China (English)

    纪慧茹; 刘春梅; 徐继培; 张倩

    2011-01-01

    目的:探讨武警官兵的下腰痛的特点及影响因素,制定预防措施及健康教育对策,为武警部队提供科学训练的依据.方法:对2007年6月至2010年6月我科门诊诊治的1806例武警部队下腰痛患者进行调查分析,了解引起下腰痛的主病因、下腰痛类型与兵种的关系、下腰痛复发的影响因素、下腰痛与兵龄长短的关系.结果:引起下腰痛的主原因为急性腰扭伤及腰肌劳损,勤务兵主是急性腰痛为主(P<0.001),而运输兵、通讯兵和公务员主是慢性腰痛(P<0.001),特种兵则急性腰痛与慢性腰痛基本接近(p=0.0897),运输兵和特种兵容易出现腰肌劳损的复发,腰肌劳损及韧带炎的复发多与不正规治疗有关,兵龄短的官兵的下腰痛主为急性腰痛,而兵龄超过3年的官兵的下腰痛主为慢性腰痛,随着兵龄的增加,慢性腰痛的发病率增加.结论:科学训练是减少武警官兵下腰痛的关键,尤其是慢性下腰痛的发生,出现下腰痛后,及时、正规的诊治是防治和避免其复发的关键.%Objective: To investigate the characteristics and affecting factors of low back pain of the Chinese people's armed police officers, it is to develop the preventive measures and strategies of health education, which is provide a scientific basis for training. Methods: Our out-patient treatment of 1806 cases of armed police was investigated from June 2007 to June 2010. Then we analysis the major cause of low back pain, relationship between type of low back pain and branches of the military, the factors of recurrence of low back pain and relationship of the length of military age. Results: The main reason for low back pain was lumbar sprain and strain of lumbar muscles. Orderlies officer was mainly acute low back pain (P< 0. 001); transport troops, communications troops and civil servants was mainly chronic low back pain (P<0. 001), and acute low back pain and chronic low back pain of special force was

  12. 新时期武警部队卫生士官队伍建设与管理的剖析%Team building and management of health non-commissioned officers in Chinese Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    宋立新; 孟庆勇; 贺智; 南克勉

    2012-01-01

    本文从新时期武警部队卫生士官队伍建设与管理的实际出发,从部队战备执勤、处突反恐、军 事训练、教育管理和救援装备等,对卫生士官的重要性、职责、存在问题进行了剖析,指出其对策是:落实 制度,强化管理;加强培训,提高质量;军地衔接,确保就业.%The new system of noncommissioned officers pf the Chinese Armed Police Forces has been implemented since the end of 2009. At present the importance of the health non-commissioned officers (NCO) is emphacized.In practice, the nealth NCO are the right-hand men of the military doctors. However, most of the heath NCOs have only the educational levels of senior even junior middle schools,haven' t received School record education, and lack of information technology knowledge and skills and Intrinsic motivation. Not willing to remain in the army and do long-term service, some of them apply forretirement.To solve these problems,the performance assessment system should be implemented and management should be strengthened. Professional trining should be enforced so as to raise the professional quality of the NCOs,for example, in syomatological, laboratory examionation, radology, etc. Attention should be paid to military-civilian interface sp as to ensure the employment of the health NCOs out of service.

  13. The construction of driver' s personality trait model of armed police force%武警部队汽车驾驶员人格特质模型的构建

    Institute of Scientific and Technical Information of China (English)

    张文; 余淑君; 王丹

    2010-01-01

    目的 探讨武警部队汽车驾驶员人格特点,构建驾驶员的人格特质模型与评价标准.方法 应用卡特尔16PF个性测验对武警部队北京、四川、内蒙古、云南等1187名汽车驾驶员进行心理测试.结果 武警部队汽车驾驶员的职业人格特质主要由稳定自控性、能动合作性、幻想开放性、聪明直率性4个因子构成,可解释总变异50.13%.结论 四个因子基本可以构建武警部队汽车驾驶员的人格特质模型,对选拔、培训和评价驾驶员具有一定的参考价值.%Objective To investigate the personality characteristics of the drivers in the Armed Police Force ( CAPF), as well as construct a personality traits model for drivers and evaluation criteria. Methods Adopting Sixteen Personality Factor Questionnaire(16PF) to collect data from 1187 CAPF drivers in Beijing,Sichuan,Inner Mongolia and Yunnan. Results The paper concludes that career personality traits of CAPF drivers are made up of 4 factors: stability and self-control, self-motivation and cooperation, fantasy and openness, intelligence and candor, which explain 50.13% of the total variance. Conclusion The four factors basically construct the personality trait model of CAPF drivers. They could also be of great significance in recruiting, training and evaluating drivers.

  14. The Latvian Armed Forces today / Raimonds Graube

    Index Scriptorium Estoniae

    Graube, Raimonds

    1999-01-01

    Ülevaade Läti kaitsevägede olukorrast, eesmärkidest, rahvusvahelisest koostööst ja valmistumisest liitumiseks NATO-ga. Tabelid: Läti kaitsejõudude planeerimise süsteem, käsuliinid, kaitsejõudude struktuur rahu- ja sõjaajal. Raimonds Graube biograafia

  15. Dynamics of Non-Steady Spiral Arms in Disk Galaxies

    CERN Document Server

    Baba, Junichi; Wada, Keiichi

    2012-01-01

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional $N$-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms are originated in the continual repetition of this non-linear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the co-rotation point. Due to interaction with their host arms, ...

  16. Paul Scherrer Institut annual report 1996. Annex II: PSI life sciences and Institute for Medical Radiobiology Newsletter 1996

    International Nuclear Information System (INIS)

    This annex to the PSI Annual Report 1996 reports on the progress achieved by the PSI Department II during 1996 in the fields of radiation medicine, radiopharmacy, radiation hygiene, positron emission tomography and medical radiobiology. figs., tab., refs

  17. Paul Scherrer Institut annual report 1995. Annex II: PSI life sciences and institute for medical radiobiology newsletter 1995

    International Nuclear Information System (INIS)

    The newsletter presents the 1995 progress report of PSI F2-Department and of the Institute for Medical Radiobiology in the fields of radiation medicine, radiopharmacy and radiation hygiene. figs., tabs., refs

  18. Paul Scherrer Institut annual report 1995. Annex II: PSI life sciences and institute for medical radiobiology newsletter 1995

    Energy Technology Data Exchange (ETDEWEB)

    Blaeuenstein, P.; Gschwend, B. [eds.

    1996-09-01

    The newsletter presents the 1995 progress report of PSI F2-Department and of the Institute for Medical Radiobiology in the fields of radiation medicine, radiopharmacy and radiation hygiene. figs., tabs., refs.

  19. System For Research On Multiple-Arm Robots

    Science.gov (United States)

    Backes, Paul G.; Hayati, Samad; Tso, Kam S.; Hayward, Vincent

    1991-01-01

    Kali system of computer programs and equipment provides environment for research on distributed programming and distributed control of coordinated-multiple-arm robots. Suitable for telerobotics research involving sensing and execution of low level tasks. Software and configuration of hardware designed flexible so system modified easily to test various concepts in control and programming of robots, including multiple-arm control, redundant-arm control, shared control, traded control, force control, force/position hybrid control, design and integration of sensors, teleoperation, task-space description and control, methods of adaptive control, control of flexible arms, and human factors.

  20. Dynamics of Non-steady Spiral Arms in Disk Galaxies

    Science.gov (United States)

    Baba, Junichi; Saitoh, Takayuki R.; Wada, Keiichi

    2013-01-01

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional N-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms originates in the continual repetition of this nonlinear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the corotation point. Due to interaction with their host arms, the energy and angular momentum of the stars change, thereby causing radial migration of the stars. During this process, the kinetic energy of random motion (random energy) of the stars does not significantly increase, and the disk remains dynamically cold. Owing to this low degree of disk heating, short-lived spiral arms can recurrently develop over many rotational periods. The resultant structure of the spiral arms in the N-body simulations is consistent with the observational nature of spiral galaxies. We conclude that the formation and structure of spiral arms in isolated disk galaxies can be reasonably understood by nonlinear interactions between a spiral arm and its constituent stars.

  1. DYNAMICS OF NON-STEADY SPIRAL ARMS IN DISK GALAXIES

    International Nuclear Information System (INIS)

    In order to understand the physical mechanisms underlying non-steady stellar spiral arms in disk galaxies, we analyzed the growing and damping phases of their spiral arms using three-dimensional N-body simulations. We confirmed that the spiral arms are formed due to a swing amplification mechanism that reinforces density enhancement as a seeded wake. In the damping phase, the Coriolis force exerted on a portion of the arm surpasses the gravitational force that acts to shrink the portion. Consequently, the stars in the portion escape from the arm, and subsequently they form a new arm at a different location. The time-dependent nature of the spiral arms originates in the continual repetition of this nonlinear phenomenon. Since a spiral arm does not rigidly rotate, but follows the galactic differential rotation, the stars in the arm rotate at almost the same rate as the arm. In other words, every single position in the arm can be regarded as the corotation point. Due to interaction with their host arms, the energy and angular momentum of the stars change, thereby causing radial migration of the stars. During this process, the kinetic energy of random motion (random energy) of the stars does not significantly increase, and the disk remains dynamically cold. Owing to this low degree of disk heating, short-lived spiral arms can recurrently develop over many rotational periods. The resultant structure of the spiral arms in the N-body simulations is consistent with the observational nature of spiral galaxies. We conclude that the formation and structure of spiral arms in isolated disk galaxies can be reasonably understood by nonlinear interactions between a spiral arm and its constituent stars.

  2. 武警部队执行地震救援中的药材保障%Medicinal materials guarantee of earthquake emergency medical relief team of the Chinese People’s Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    贺智; 安茜; 谢红; 郭海涛; 叶路

    2015-01-01

    Objective To develop a reasonable and scientific scheme for medicinal materials that disaster relief teams of the Chinese People’s Armed Police Forces (CPAPF) should carry in earthquake relief work. Methods The cases of disposition of medicinal materials of the disaster relief teams of the CPAPF in Wenchuan and Yushu Earthquake areas , 2008 and 2010 respectively, were investigated. The relevant disease spectra during the early periods of earthquake (within 3 days) were analyzed. In addition, literatrure review and expert counseling were used. According to the maximum outpatient quantity of 800 persons, the bases of medicinal materials needed for single appropriate medical skills were calculated based on the“Standard for the guarantee of military related medicines”and the“Standards of millitary matrerials of the Chinese Armed Police Forces”, and with the method of management of single disease cases. Thus the species of medicinal materials and quantities thererof necessary for the relief teams during the first 3 days after earthquake were determined . Results A detailed list of medicinal materials any relief team should carry during the first 3 days after earthquake, including 10 categories with 87 species, had been developed. Conclusion A reasonable and scientific scheme for medicinal materials carried by disaster relief teams of the CPAPF in earthquake relief work based on quantitative study has been made, thus providing a useful model for reference.%目的:为武警部队医学救援队携运药材制定合理、科学的药材保障配置方案。方法分析总结汶川和玉树地震救援中药材配置方面的现状,并根据地震早期伤病谱,采用文献调研法、以《军队相关药材保障标准》及《武警部队战材标准》为基本依据,借鉴单病种病例管理方法,同时结合救援专家建议,计算单项适宜医学治疗技术所需的药材保障基数,从而确定武警部队医学救援队

  3. Nuclear arms: ethics, strategy, politics

    Energy Technology Data Exchange (ETDEWEB)

    Woolsey, R.J. (ed.)

    1984-01-01

    The range of debate over strategy and arms control today is broader than it was in the late 1950s and early 1960s. In part this is because the early 1980s debate has involved questioning of the fundamental notion of deterrence - by no less than the American Catholic bishops. Today's debate has also seen a national nuclear freeze campaign that, although its congressional supporters have held firmly to a bilateral approach, was tilted perceptibly towards unilateralism by noncongressional leaders at their national conference in February 1983. In one way or another the authors wrestle with different aspects of one central question: could the beginning steps for any consensus be possible, in today's climate, on strategic issues. Ethical issues are addressed in the first 3 papers: Charles Krauthammer, On Nuclear Morality; Patrick Glynn, The Moral Case for the Arms Buildup; and Michael Quinlarc, Thinking Deterrence Through. Three chapters on strategic considerations include: Brent Snowcroft, Understanding the US Strategic Arsenal; William J. Perry, Technological Prospects for US Strategic Forces; and Richard Burt, The Strategic and Political Lessons of INF. Arms control and politics is treated in chapters by: Walter B. Slocombe, Arms Control: Prospects; and Colin S. Gray, Arms Control: Problems. The nonnuclear dimensions of strategy are discussed in chapters by Amory B. and L. Hunter Lovins, Reducing Vulnerability - The Energy Jugular; and Robert Kupperman, Vulnerable America. The chapters on space and defense are: Hans Mark, Arms Control and Space Technology; and Newt Gingrich and John Madison, Space and National Defense. The concluding chapters are by Sen. Sam Nunn, The Need to Reshape Military Stategy; and the editor, R. James Woolsey, The Politics of Vulnerability, 1980-1983.

  4. Effects of radiobiological uncertainty on shield design for a 60-day lunar mission

    Science.gov (United States)

    Wilson, John W.; Nealy, John E.; Schimmerling, Walter

    1993-01-01

    Some consequences of uncertainties in radiobiological risk due to galactic cosmic ray exposure are analyzed to determine their effect on engineering designs for a first lunar outpost - a 60-day mission. Quantitative estimates of shield mass requirements as a function of a radiobiological uncertainty factor are given for a simplified vehicle structure. The additional shield mass required for compensation is calculated as a function of the uncertainty in galactic cosmic ray exposure, and this mass is found to be as large as a factor of 3 for a lunar transfer vehicle. The additional cost resulting from this mass is also calculated. These cost estimates are then used to exemplify the cost-effectiveness of research.

  5. Ill-posed problem and regularization in reconstruction of radiobiological parameters from serial tumor imaging data

    International Nuclear Information System (INIS)

    The main objective of this article is to improve the stability of reconstruction algorithms for estimation of radiobiological parameters using serial tumor imaging data acquired during radiation therapy. Serial images of tumor response to radiation therapy represent a complex summation of several exponential processes as treatment induced cell inactivation, tumor growth rates, and the rate of cell loss. Accurate assessment of treatment response would require separation of these processes because they define radiobiological determinants of treatment response and, correspondingly, tumor control probability. However, the estimation of radiobiological parameters using imaging data can be considered an inverse ill-posed problem because a sum of several exponentials would produce the Fredholm integral equation of the first kind which is ill posed. Therefore, the stability of reconstruction of radiobiological parameters presents a problem even for the simplest models of tumor response. To study stability of the parameter reconstruction problem, we used a set of serial CT imaging data for head and neck cancer and a simplest case of a two-level cell population model of tumor response. Inverse reconstruction was performed using a simulated annealing algorithm to minimize a least squared objective function. Results show that the reconstructed values of cell surviving fractions and cell doubling time exhibit significant nonphysical fluctuations if no stabilization algorithms are applied. However, after applying a stabilization algorithm based on variational regularization, the reconstruction produces statistical distributions for survival fractions and doubling time that are comparable to published in vitro data. This algorithm is an advance over our previous work where only cell surviving fractions were reconstructed. We conclude that variational regularization allows for an increase in the number of free parameters in our model which enables development of more

  6. Radiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans

    OpenAIRE

    Liang, X.; Penagaricano, J.; Zheng, D.; Morrill, S.; Zhang, X; Corry, P.; Griffin, R. J.; Han, E. Y.; Hardee, M.; Ratanatharathom, V.

    2016-01-01

    Background The aim of this study is to evaluate the radiobiological impact of Acuros XB (AXB) vs. Anisotropic Analytic Algorithm (AAA) dose calculation algorithms in combined dose-volume and biological optimized IMRT plans of SBRT treatments for non-small-cell lung cancer (NSCLC) patients. Methods Twenty eight patients with NSCLC previously treated SBRT were re-planned using Varian Eclipse (V11) with combined dose-volume and biological optimization IMRT sliding window technique. The total dos...

  7. Ill-posed problem and regularization in reconstruction of radiobiological parameters from serial tumor imaging data

    Science.gov (United States)

    Chvetsov, Alevei V.; Sandison, George A.; Schwartz, Jeffrey L.; Rengan, Ramesh

    2015-11-01

    The main objective of this article is to improve the stability of reconstruction algorithms for estimation of radiobiological parameters using serial tumor imaging data acquired during radiation therapy. Serial images of tumor response to radiation therapy represent a complex summation of several exponential processes as treatment induced cell inactivation, tumor growth rates, and the rate of cell loss. Accurate assessment of treatment response would require separation of these processes because they define radiobiological determinants of treatment response and, correspondingly, tumor control probability. However, the estimation of radiobiological parameters using imaging data can be considered an inverse ill-posed problem because a sum of several exponentials would produce the Fredholm integral equation of the first kind which is ill posed. Therefore, the stability of reconstruction of radiobiological parameters presents a problem even for the simplest models of tumor response. To study stability of the parameter reconstruction problem, we used a set of serial CT imaging data for head and neck cancer and a simplest case of a two-level cell population model of tumor response. Inverse reconstruction was performed using a simulated annealing algorithm to minimize a least squared objective function. Results show that the reconstructed values of cell surviving fractions and cell doubling time exhibit significant nonphysical fluctuations if no stabilization algorithms are applied. However, after applying a stabilization algorithm based on variational regularization, the reconstruction produces statistical distributions for survival fractions and doubling time that are comparable to published in vitro data. This algorithm is an advance over our previous work where only cell surviving fractions were reconstructed. We conclude that variational regularization allows for an increase in the number of free parameters in our model which enables development of more

  8. Heavy Charged Particle Radiobiology: Using Enhanced Biological Effectiveness and Improved Beam Focusing to Advance Cancer Therapy

    OpenAIRE

    Allen, Christopher; Borak, Thomas B.; Tsujii, Hirohiko; Jac A Nickoloff

    2011-01-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilitie...

  9. Installation of a flow cytometry facility and some applications in radiobiology

    International Nuclear Information System (INIS)

    Flow cytometry has enormous potential in many areas of experimental pathology. Details of the installation and commissioning of a flow cytometer at the Harwell Laboratory are described. Following an explanation of the principles of flow cytometry, several applications to specific problems in radiobiology are discussed. Also included are results of some preliminary studies with the Harwell flow cytometer on samples such as blood, bone marrow, macrophages and cell cultures, and a discussion of future applications. (author)

  10. Radiobiological investigations of the accelerators at the Joint Institute for Nuclear Research

    International Nuclear Information System (INIS)

    Full text: The Joint Institute for Nuclear Research (JINR) has the different accelerators of heavy charged particles for various energies. The radiobiological investigations at these machines have been commenced some tens years ago. The main task of scientific research at the Laboratory of Radiation Biology of JINR is connected with investigations of genetic effects of accelerated charged particles with wide spectrum of energies. Using accelerated heavy ions with low energy, the following directions of researches in radiobiology and radiation genetics were performed: study of RBE problem in connection with DNA repair processes; investigation of the molecular mechanisms of point and structural mutation induction in prokaryotic cells and the influence of the repair systems on the mutagenic processes after irradiation in a wide range of linear energy transfer (LET); study of the SOS-response of bacterial cells by using SOS-chromo test, SOS-lux test and by criteria of α-prophage induction in lysogenic bacteria after irradiation by heavy ions; study of the regularities of gene mutation inductions in yeast cells under action of ionizing radiation with different LET; investigations of the regularities of unstable and stable chromosomal aberrations (translocations) in human cells under action of ionizing radiation with wide LET range; study of mutagenic (HPRT gene) effects in mammalian cells in culture after heavy charged particle irradiation and chromosomal instability in HPRT-mutant clones after irradiation; study of the cytogenetic effects in mammalian cells irradiated by heavy ions in low doses. The radiobiological investigations with high energy are carried out at the Nuclotron - the new JINR accelerator. The programme involves the most vital tasks of modern radiobiology: study of the regularities and mechanisms of stable and unstable chromosome aberration induction in human cells; genetic control of check-point regulation in low eukaryotic cells; study of the

  11. Radiobiological work using a negative pion beam at the Rutherford Laboratory 1971-76

    International Nuclear Information System (INIS)

    The subject is discussed in two sections: physics experiments (including, inter alia, dose measurement, LET distribution, radiation products of spallation); radiobiological studies (including separate reports as follows: review of experimental programme; some in vivo effects of negative pions in mice; survival and recovery of Hela cells in vitro; negative pion dose-response curves for frozen Hela cells; response of vicia faba to irradiation with negative pions; pion experiments with chromosome aberrations). (U.K.)

  12. The impact of modeling nuclear fragmentation on delivered dose and radiobiology in ion therapy.

    Science.gov (United States)

    Lühr, Armin; Hansen, David C; Teiwes, Ricky; Sobolevsky, Nikolai; Jäkel, Oliver; Bassler, Niels

    2012-08-21

    The importance of nuclear interactions for ion therapy arises from the influence of the particle spectrum on, first, radiobiology and therefore also on treatment planning, second, the accuracy of measuring dose and, third, the delivered dose distribution. This study tries to determine the qualitative as well as the quantitative influence of the modeling of inelastic nuclear interactions on ion therapy. Thereby, three key disciplines are investigated, namely dose delivery, dose assessment and radiobiology. In order to perform a quantitative analysis, a relative comparison between six different descriptions of nuclear interactions is carried out for carbon ions. The particle transport is simulated with the Monte Carlo code SHIELD-HIT10A while dose planning and radiobiology are covered by the analytic treatment planning program for particles TRiP, which determines the relative biological effectiveness (RBE) with the local effect model. The obtained results show that the physical dose distribution can in principle be significantly influenced by the modeling of fragmentation (about 10% for a 20% change in all inelastic nuclear cross sections for a target volume ranging from 15 to 25 cm). While the impact of nuclear fragmentation on stopping power ratios can be neglected, the fluence correction factor may be influenced by the applied nuclear models. In contrast to the results for the physical dose, the variation of the RBE is only small (about 1% for a 20% change in all inelastic nuclear cross sections) suggesting a relatively weak dependence of radiobiology on the detailed composition of the particle energy spectrum of the mixed radiation field. Also, no significant change (about 0.2 mm) of the lateral penumbra of the RBE-weighted dose is observed.

  13. “经济与核武并行路线”及朝鲜经济政策走向%Strategy of Carrying out Economic Construction and Building Nuclear Armed Forces Simultaneously and North Korean Economic Policy Trend

    Institute of Scientific and Technical Information of China (English)

    谭红梅

    2015-01-01

    North Korea proposed the strategy of carrying out economic construction and building nuclear armed forces simultaneously on March 2013.For various factors, economy was more emphasized in this strategy than the similar policy in the past while the national defense was the priority.However, such an economic reform can not re-move the drawbacks of planned economy;therefore, it is limited.Besides, factors such as nuclear weapon develop-ment and investment environment may impede and challenge North Korea’ s economic cause.It is proposed that North Korea should improve its economic efficiency and management, as well as attract more foreign investment and open wider to the outside world.%2013年3月,朝鲜提出金正恩时代的“国家运行基本政策”———“经济与核武并行路线”。其中经济领域的任务,呈现不同以往的特征,对经济的重视较以往已达到了更高的程度,多种因素促使朝鲜把经济当作最重要的任务之一,同样为“并行路线”,金日成时期的“并行路线”重在国防,金正恩则将焦点置于经济。然而,不涉及计划经济本身的弊端的经济改革仍将是有限度的,加之核开发问题、投资环境等一系列制约性因素,未来朝鲜在经济领域所推行的任务仍将面临各种障碍和挑战,其预期的效果也将有待时间的检验。在内部提高效率改善经济管理,同时为从外部引进外资而扩大开放将成为今后一个时期朝鲜的经济政策方向。

  14. 组织支持感对特战队员人格与情绪耗竭的调节作用%Perceived organizational support's moderating effect on the relationship between personality and emotional exhaustion of Chinese armed police force

    Institute of Scientific and Technical Information of China (English)

    裴改改; 郭文汇; 李永娟; 张玉梅

    2014-01-01

    Objective To test the hypothesis that perceived organizational support(POS) plays a moderate role in the process of personality' s effect on emotional exhaustion.Methods Using POS,Revised NEO Personality Inventory and Emotional Exhaustion Inventory,376 special combat soldiers were tested from the Chinese Armed Police Force.Then SPSS 16.0 was used to conduct descriptive analysis,correlational analysis and hierarchical regression analysis.Results The interaction of neuroticism and POS as well as the interaction of conscientiousness and POS were significant or marginally significant,respectively.POS significantly moderated the relationship between neuroticism and emotional exhaustion(β=-0.19,t=-2.82,P<0.01)as well as the relationship between conscientiousness and emotional exhaustion(β=-0.12,t=-1.95,P=0.052).Conclusion Neuroticism and conscientiousness are more strongly related with emotional exhaustion among individuals with low POS than high POS.%目的 探讨组织支持感在人格影响特战队员情绪耗竭过程中的调节作用.方法 采用组织支持感问卷、大五人格量表和情绪耗竭问卷对来自6个省区的武警部队的376名特战队员进行问卷调查,并使用SPSS16.0进行描述性统计分析、相关分析和多层回归分析.结果 神经质和组织支持感的交互作用以及尽责性与组织支持感的交互作用均显著或边缘显著,即组织支持感显著调节神经质与情绪耗竭的关系(β=-0.19,t=-2.82,P<0.01),以及尽责性与情绪耗竭的关系(β=-0.12,t=-1.95,P=0.052).结论 神经质和尽责性在低组织支持感的情况下对情绪耗竭的影响较强,而在高组织支持感的情况下对情绪耗竭的影响减弱.

  15. Analysis and research of overweight among the officers and soldiers in certain armed forces%某部队官兵发生超重的影响因素研究

    Institute of Scientific and Technical Information of China (English)

    陈英; 刘庆森; 杨云生; 郭旭

    2011-01-01

    目的 调查某部队官兵发生超重的影响因素,为部队官兵的生活、训练提供更科学的指导.方法 问卷调查采用双盲法(7359份问卷),将结果用CHISS软件实现非条件Logistic回归分析,筛选出对超重有显著影响的危险因素.结果 有效应答7338份,调查结果显示,睡眠时间少(<6 h)、失去亲人、情绪压抑、进食速度快(<5 min)、运动强度小、暴饮暴食、工作压力大、出生在城市、婚后9项因素与超重有明确相关性;并且发现前6项是对超重有显著影响的独立危险因素(P<0.01).结论 超重和肥胖的原因除了公认的运动强度小、高热量饮食外,睡眠时间少、进食速度快、情绪压抑等因素也与超重密切相关,应引起人们的足够重视.%Objective To survey and analyze the influencing factors of overweight in the officers and soldiers in certain armed forces,and to offer more scientific guidance on the living and training of the officers and soldiers. Methods Investigations with questionnaires using double blind method were carried out and logistic regression analysis were implemented by software CHISS. The significant risk factors which affected the overweight were picked out. Results The logistic regression analysis showed that the factors affecting overweight include sleep deprivation, missing family members,depressed mood, eating too fast,low exercise intensity, binge overeating, overwork,city background and post marriage. The first six items were the significant independent risk factors of inducing overweight (P<0.01). Conclusions The influencing factors of overweight and obesity include not only minor amount of exercise and high calorie diet, but also sleep deprivation(≤6h) .eating too fast (≤5min), and depressed mood etc. These factors are important and should be emphasized.

  16. Fast neutrons set the pace. [Radiobiological investigations with fast neutrons at the CSIR cyclotron in Pretoria

    Energy Technology Data Exchange (ETDEWEB)

    Hough, J.H.; Slabbert, J.P. (Council for Scientific and Industrial Research, Pretoria (South Africa). National Accelerator Centre)

    1985-01-01

    Radiobiological investigations with fast neutrons have been initiated at the CSIR cyclotron in Pretoria. It was proposed some years ago to create a neutron therapy facility using the CSIR cyclotron. Neutrons are classified as high linear energy transfer (LET) particles. Biological damage occurring in tissue is a direct function of the LET of the incident radiation. To quantify the biological effects of different types of radiation on mammalian cells, several procedures and concepts have evolved from radiobiological research. Probably the most significant laboratory techniques developed, were the derivation of cell survival curves which are obtained by determining the number of cell colonies that have survived a certain radiation dose. A semi-logarithmic plot of surviving fraction versus the absorbed dose yields the survival curve. Dose modifying factors such as the relative biological effectiveness (RBE) of the radiation can be quantified in terms of this relationship. A radiobiological programme has to be undertaken before patients can receive neutron therapy at the CSIR cyclotron. The article is a discussion of this programme.

  17. ARM Airborne Carbon Measurements (ARM-ACME) and ARM-ACME 2.5 Final Campaign Reports

    Energy Technology Data Exchange (ETDEWEB)

    Biraud, S. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Tom, M. S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sweeney, C. [NOAA Earth Systems Research Lab., Boulder, CO (United States)

    2016-01-01

    We report on a 5-year multi-institution and multi-agency airborne study of atmospheric composition and carbon cycling at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, with scientific objectives that are central to the carbon-cycle and radiative-forcing goals of the U.S. Global Change Research Program and the North American Carbon Program (NACP). The goal of these measurements is to improve understanding of 1) the carbon exchange of the Atmospheric Radiation Measurement (ARM) SGP region; 2) how CO2 and associated water and energy fluxes influence radiative-forcing, convective processes, and CO2 concentrations over the ARM SGP region, and 3) how greenhouse gases are transported on continental scales.

  18. 78 FR 26328 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2013-05-06

    ...)(1) of the Arms Export Control Act, as amended (U) (i) Prospective Purchaser: North Atlantic Treaty Organization (ii) Total Estimated Value: * As defined in Section 47(6) of the Arms Export Control Act. Major... NATO and furthering weapon system standardization and interoperability with U.S. forces. NATO...

  19. 76 FR 72180 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2011-11-22

    ... continues to be, an important force for political stability and economic progress in East Asia. The Royal... Section 36(b)(1) of the Arms Export Control Act, as amended (i) Prospective Purchaser: Malaysia. (ii... Arms Export Control Act. Policy Justification Malaysia--AIM-9X-2 SIDEWINDER Missiles The Government...

  20. Engaging armed non-state actors in mechanisms for protection

    Directory of Open Access Journals (Sweden)

    Pauline Lacroix

    2011-03-01

    Full Text Available Experience of engagement with armed non-state actors on the landmine ban may point the way to innovative approaches to preventing forced displacement and other abuses of human rights....

  1. 武警森林部队战士休整期心理健康状况调查%On Investigation the mental health status in the period of rest of Forest Armed Police Force

    Institute of Scientific and Technical Information of China (English)

    刘茵; 曹春霞; 任晓东; 任晓红; 王熙; 李浴峰

    2012-01-01

    [Objective] To realize the mental health status of Forest Armed Police Forces(FAPF) in the period of rest . [Methods] Multistage sampling survey methods were used to sample 1167 FAPF soldier. Symptom Checklist(SCL-90) was used to realize the psychological conditions. [Results] 1 167 soldiers in the survey, who had significant psychological problems, accounted for 4.88%. Coercion 、 hostility、 somatizatioiu、 others and interpersonal sensitivity factors had higher detection rates. SCL-90 total-sharing and the factor scores were lower than Chinese national norm and Chinese soldiers norm (P <0.01); The mental health factor of FAPF soldiers in different units were significantly different(P <0.05); low-cultural group scores were lower than high-cultural group in the total-sharing, depression, anxiety, hostility, paranoia and psychosis factor, there were statistically different(P <0.05); there was not significantly different no matter the only child soldiers、former residence before recruited and different ranks or not(P <0.05). [Conclusion] From this survey, it suggests that the general level of mental health status of FAPF in the rest period is better than that of national or soldiers norm.%[目的]了解森林部队休整期间心理健康状况.[方法]采用多阶段整群抽样调查方法,在武警森林基层部队抽取1167名战士,采用症状自评量表(Symptom Checklist,SCL-90)调查了解心理状况.[结果]1167名被调查战士中,总均分提示大于等于2分的占4.88%,10类因子中强迫、敌对、躯体化、其他、人际敏感因子有较高检出率.SCL-90总均分及各因子分均低于中国地方人群常模和中国军人常模(P<0.01);不同单位战士心理健康状况各因子得分有显著性差异(P<0.05);低文化组在总均分、抑郁、焦虑、敌对、偏执和精神病性因子得分低于高文化组,存在统计学意义(P<0.05);是否独生子、兵源地和警衔不同的战士,心理健

  2. 武警部队部分护理人员卫勤战备能力的调查与分析%Investigation and Analysis on Combat Readiness Capacity of Nurses in Armed Police Force Hospitals

    Institute of Scientific and Technical Information of China (English)

    唐秀花; 徐丽; 陆萍; 解温品; 胡青; 刘蕾

    2012-01-01

    Objective To investigate the combat readiness capacity of nurses in Armed Police Force (APF) hospitals and to discuss the strategy to improve their combat readiness capacity. Methods From January 2010 to December 2011, the data of combat readiness capacity of 1321 nurses who had participated in major health service of Olympics security, preservation of stability, earthquake relief and flood rescue, National Games security, World Expo security and Asian Games security from 5 Class-Ⅲ Level-A hospitals and 2 motor division hospital of APF(including soldier nurses, non-commissioned civilian nurses, noncommissioned nurses and contract nurses). Results The survey results showed that the clinical nurses gained the highest scores (3. 16±0. 85) in clinical nursing capacity in the three dimensions of combat readiness evaluation; compared with the combat readiness, they gained higher scores in the overall scores of the relative sense of identity related to combat readiness and the highest scores were in personal matters / physical fitness / psychosocial readiness (3. 96±0. 86). Conclusion The combat readiness capacity of the APF nurses needs to be improved, especially in the ability of military action and soldier/survival skills. We need to develop a normative, targeted training program to further improve the quality and effectiveness of the combat readiness training.%目的 了解我国武警部队部分护理人员卫勤战备能力的现状和水平,探讨提高其战备能力的方法.方法 2010年1月至2011年12月,对参加奥运会安保、处理突发事件、维护社会稳定、抗震救灾、抗洪抢险、全运会安保、世博会安保、亚运会安保等重大卫勤任务的武警部队5所三级甲等医院和2所机动师医院1 321名护理人员(包括军人护士、非现役文职护士、士官护士、合同制护士等)进行问卷调查.结果 有关战备能力评估的3个维度中,护理人员的临床护理能力得分最高,为(3.16±0

  3. Revising the Radiobiological Model of Synchronous Chemotherapy in Head-and-Neck Cancer: A New Analysis Examining Reduced Weighting of Accelerated Repopulation

    International Nuclear Information System (INIS)

    Purpose: Previous studies of synchronous chemoradiation therapy have modeled the additional effect of chemotherapy as additional radiation therapy biologically effective dose (BED). Recent trials of accelerated versus conventional fractionation chemoradiation have cast doubt on such modeling. The purpose of this study was to identify alternative models. Methods and Materials: Nine trials of platinum-based chemoradiation were identified. In radiation therapy-alone arms, the radiation therapy BED for tumor was calculated using standard parameters. In chemoradiation arms, 3 methods were used to calculate tumor BED (tBED): additional BED, addition of 9.3 Gy BED for tumor to the radiation therapy BED; zero repopulation, BED with no correction for repopulation; variable tp (the average doubling time during accelerated repopulation), values of tp 3-10 were used to examine a partial suppression of repopulation. The correlations between the calculated percentage change in tBED for each method and observed percentage change in local control were assessed using the Pearson product moment correlation. Results: Significant correlations were obtained for all 3 methods but were stronger with zero repopulation (P=.0002) and variable tp (tp = 10) (P=.0005) than additional BED (P=.02). Conclusions: Radiobiological models using modified parameters for accelerated repopulation seem to correlate strongly with outcome in chemoradiation studies. The variable tp method shows strong correlation for outcome in local control and is potentially a more suitable model in the chemoradiation setting. However, a lack of trials with an overall treatment time of more than 46 days inhibits further differentiation of the optimal model

  4. Estimation of Radiobiologic Parameters and Equivalent Radiation Dose of Cytotoxic Chemotherapy in Malignant Glioma

    International Nuclear Information System (INIS)

    Purpose: To determine the radiobiologic parameters for high-grade gliomas. Methods and Materials: The biologic effective dose concept is used to estimate the α/β ratio and K (dose equivalent for tumor repopulation/d) for high-grade glioma patients treated in a randomized fractionation trial. The equivalent radiation dose of temozolomide (Temodar) chemotherapy was estimated from another randomized study. The method assumes that the radiotherapy biologic effective dose is proportional to the adjusted radiotherapy survival duration of high-grade glioma patients. Results: The median tumor α/β and K estimate is 9.32 Gy and 0.23 Gy/d, respectively. Using the published surviving fraction after 2-Gy exposure (SF2) data, and the above α/β ratio, the estimated median α value was 0.077 Gy-1, β was 0.009 Gy-2, and the cellular doubling time was 39.5 days. The median equivalent biologic effective dose of temozolomide was 11.03 Gy9.3 (equivalent to a radiation dose of 9.1 Gy given in 2-Gy fractions). Random sampling trial simulations based on a cure threshold of 70 Gy in high-grade gliomas have shown the potential increase in tumor cure with dose escalation. Partial elimination of hypoxic cells (by chemical hypoxic cell sensitizers or carbon ion therapy) has suggested that considerable gains in tumor control, which are further supplemented by temozolomide, are achievable. Conclusion: The radiobiologic parameters for human high-grade gliomas can be estimated from clinical trials and could be used to inform future clinical trials, particularly combined modality treatments with newer forms of radiotherapy. Other incurable cancers should be studied using similar radiobiologic analysis

  5. Development of a compact laser-produced plasma soft X-ray source for radiobiology experiments

    Science.gov (United States)

    Adjei, Daniel; Ayele, Mesfin Getachew; Wachulak, Przemyslaw; Bartnik, Andrzej; Wegrzynski, Łukasz; Fiedorowicz, Henryk; Vyšín, Luděk; Wiechec, Anna; Lekki, Janusz; Kwiatek, Wojciech M.; Pina, Ladislav; Davídková, Marie; Juha, Libor

    2015-12-01

    A desk-top laser-produced plasma (LPP) source of soft X-rays (SXR) has been developed for radiobiology research. The source is based on a double-stream gas puff target, irradiated with the focused beam of a commercial Nd:YAG laser. The source has been optimized to get a maximum photon emission from LPP in the X-ray "water window" spectral wavelength range from 2.3 nm (i.e., an absorption edge of oxygen) to 4.4 nm (i.e., an absorption edge of carbon) (280-540 eV in photon energy units) by using argon gas-puff target and spectral filtering by free-standing thin foils. The present source delivers nanosecond pulses of soft X-rays at a fluence of about 4.2 × 103 photons/μm2/pulse on a sample placed inside the vacuum chamber. In this paper, the source design, radiation output characterization measurements and initial irradiation experiments are described. The source can be useful in addressing observations related to biomolecular, cellular and organisms' sensitivity to pulsed radiation in the "water window", where carbon atoms absorb X-rays more strongly than the oxygen, mostly present in water. The combination of the SXR source and the radiobiology irradiation layout, reported in this article, make possible a systematic investigation of relationships between direct and indirect action of ionizing radiation, an increase of a local dose in carbon-rich compartments of the cell (e.g., lipid membranes), an experimental estimation of a particular role of the Auger effect (in particular in carbon atoms) in the damage to biological systems, and the study of ionization/excitation-density (LET - Linear Energy Transfer) and dose-rate effects in radiobiology.

  6. Radiobiological Determination of Dose Escalation and Normal Tissue Toxicity in Definitive Chemoradiation Therapy for Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Warren, Samantha, E-mail: Samantha.warren@oncology.ox.ac.uk [Department of Oncology, Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford (United Kingdom); Partridge, Mike [Department of Oncology, Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford (United Kingdom); Carrington, Rhys [Velindre Cancer Centre, Velindre Hospital, Cardiff (United Kingdom); Hurt, Chris [Wales Cancer Trials Unit, School of Medicine, Heath Park, Cardiff (United Kingdom); Crosby, Thomas [Velindre Cancer Centre, Velindre Hospital, Cardiff (United Kingdom); Hawkins, Maria A. [Department of Oncology, Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford (United Kingdom)

    2014-10-01

    Purpose: This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity. Methods and Materials: Twenty-one patients with mid-esophageal cancer were selected from the SCOPE1 database (International Standard Randomised Controlled Trials number 47718479), with a mean planning target volume (PTV) of 327 cm{sup 3}. A boost volume, PTV2 (GTV + 0.5 cm margin), was created. Radiobiological modeling of tumor control probability (TCP) estimated the dose required for a clinically significant (+20%) increase in local control as 62.5 Gy/25 fractions. A RapidArc (RA) plan with a simultaneously integrated boost (SIB) to PTV2 (RA{sub 62.5}) was compared to a standard dose plan of 50 Gy/25 fractions (RA{sub 50}). Dose-volume metrics and estimates of normal tissue complication probability (NTCP) for heart and lungs were compared. Results: Clinically acceptable dose escalation was feasible for 16 of 21 patients, with significant gains (>18%) in tumor control from 38.2% (RA{sub 50}) to 56.3% (RA{sub 62.5}), and only a small increase in predicted toxicity: median heart NTCP 4.4% (RA{sub 50}) versus 5.6% (RA{sub 62.5}) P<.001 and median lung NTCP 6.5% (RA{sub 50}) versus 7.5% (RA{sub 62.5}) P<.001. Conclusions: Dose escalation to the GTV to improve local control is possible when overlap between PTV and organ-at-risk (<8% heart volume and <2.5% lung volume overlap for this study) generates only negligible increase in lung or heart toxicity. These predictions from radiobiological modeling should be tested in future clinical trials.

  7. Tcp and NTCP radiobiological models: conventional and hypo fractionated treatments in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Astudillo V, A.; Paredes G, L. [ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico); Resendiz G, G.; Posadas V, A. [Hospital Angeles Lomas, Av. Vialidad de la Barranca s/n, Col. Valle de las Palmas, 52763 Huixquilucan de Degallado, Estado de Mexico (Mexico); Mitsoura, E. [Universidad Autonoma del Estado de Mexico, Facultad de Medicina, Paseo Tollocan, Esq. Jesus Carranza s/n, Col. Moderna de la Cruz, 50180 Toluca, Estado de Mexico (Mexico); Rodriguez L, A.; Flores C, J. M., E-mail: armando.astudillo@inin.gob.mx [Hospital Medica Sur, Puente de Piedra 150, Col. Toriello Guerra, 14050 Tlalpan, Mexico D. F. (Mexico)

    2015-10-15

    The hypo and conventional fractionated schedules performance were compared in terms of the tumor control and the normal tissue complications. From the records of ten patients, treated for adenocarcinoma and without mastectomy, the dose-volume histogram was used. Using radiobiological models the probabilities for tumor control and normal tissue complications were calculated. For both schedules the tumor control was approximately the same. However, the damage in the normal tissue was larger in conventional fractionated schedule. This is important because patients assistance time to their fractions (15 fractions/25 fractions) can be optimized. Thus, the hypo fractionated schedule has suitable characteristics to be implemented. (Author)

  8. Extrapolation ionisation chamber measurements on beta-emitting sources produced for the CEGB collaborative radiobiology programme

    International Nuclear Information System (INIS)

    This report describes the structure and application of an extrapolation ionisation chamber used for measuring dose-rates from plane and point beta-emitting sources. These measurements form the basis of the dosimetry for a collaborative radiobiological study of skin to study both stochastic and non-stochastic effects. A small sample from the wide range of measurements undertaken in the programme has been selected to illustrate the procedures involved. The extrapolation chamber is currently being automated and it is intended that this report should provide a source reference to the basis of the measurements made between 1977-86. (author)

  9. Physical and cellular radiobiological properties of heavy ions in relation to cancer therapy applications

    International Nuclear Information System (INIS)

    A variety of experiments have been carried out in vitro on several mammalian cell lines with carbon, neon, silicon and argon beams at 14 and 24 cm depth penetration. The results of these experiments substantiate the conceptual basis for physical and radiobiological advantages of accelerated heavy-ion beams in cancer therapy. The best biologically effective depth dose ratio for situations corresponding to therapy needs can be obtained with accelerated carbon beams. The depression of the oxygen effect with silicon or argon ion beams is greater than that achievable with neutrons or pions, or with heavy ions of lower atomic number

  10. Research in radiobiology. Annual report of work in progress in the Internal Irradiation Program

    International Nuclear Information System (INIS)

    Survival data on 160 nonirradiated control beagles of the University of Utah's Radiobiology Laboratory were analyzed. The animals died during a period from 1958 into 1979. The average age at death of animals which died during the 1958 to 1965 interval was significantly less than that of those whose deaths occurred in the 1965 to 1979 interval. The best estimate for average age at death for Super-Selected nonirradiated control beagles of the colony is 4864 +- 901 days. The Super-Selected dogs excluded those dying because of epilepsy, lymphosarcoma, lymphoma or accidents, and also excluded all dogs dying before 1966

  11. Environmental Research Division annual report: Center for Human Radiobiology, July 1982-June 1983

    International Nuclear Information System (INIS)

    This is the fourteenth Annual Report of the Center for Human Radiobiology. New cases of bone cancer and carcinoma of head sinuses are occurring at a rate of about one per year in patients who acquired radium burdens 50 to 60 years ago. Several papers deal with dosimetry of alpha-emitting radionuclides in man, in animals, or in the environment. The report concludes with an appendix containing data on the exposure of 2312 persons whose radium content has been determined and an appendix listing the classical radium-related malignancies (osteosarcomas and carcinomas of the paranasal sinuses and mastoid)

  12. The new hybrid thermal neutron facility at TAPIRO reactor for BNCT radiobiological experiments.

    Science.gov (United States)

    Esposito, J; Rosi, G; Agosteo, S

    2007-01-01

    A new thermal neutron irradiation facility, devoted to carry out both dosimetric and radiobiological studies on boron carriers, which are being developed in the framework of INFN BNCT project, has been installed at the ENEA Casaccia TAPIRO research fast reactor. The thermal column, based on an original, hybrid, neutron spectrum shifter configuration, has been recently become operative. In spite of its low power (5 kW), the new facility is able to provide a high thermal neutron flux level, uniformly distributed inside the irradiation cavity, with a quite low gamma background. The main features and preliminary benchmark measurements of the Beam-shaping assembly are here presented and discussed.

  13. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 18. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H. Peter; Zips, Daniel (eds.)

    2009-07-15

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity.

  14. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 25. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Krause, Mechthild [Universitaetsklinikum Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologie; Cordes, Nils [Universitaetsklinikum Technische Univ. Dresden (Germany). OncoRay - Nationales Zentrum fuer Strahlenforschung in der Radioonkologie; Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany); Petersen, Cordula [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Rodemann, H. Peter [Universitaetsklinikum Tuebingen (Germany). Sektion fuer Strahlenbiologie; Rothkamm, Kai [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Lab. fuer Strahlentherapie und Experimentelle Radioonkologie; Zips, Daniel (ed.) [Tuebingen Univ. (Germany). Universitaetsklinik fuer Radioonkologie

    2016-05-01

    The proceedings of the 25th symposium on experimental radiotherapy and clinical radiobiology include papers on the following issues: radiotherapy individualization based on imaging; pre-clinic imaging and new experimental methods; methods and models, micromilieu and metabolism, combined therapy; secondary tumors following radiotherapy; radiogenic effects in normal tissue; resistance mechanism of tumors and normal tissue; personalized radio-oncology - which biological data are needed; pre-clinic and personalized radio-oncology; biomarkers - pre-clinic and translational; translational examinations for personalized radio-oncology.

  15. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness

    Science.gov (United States)

    Blakely, E. A.; Kronenberg, A.; Chatterjee, A. (Principal Investigator)

    1998-01-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  16. Development of a soft X-ray microprobe for single cell radiobiology

    Institute of Scientific and Technical Information of China (English)

    CHEN Liang; YAN Jingwen; JIANG Shiping; YU Yang

    2009-01-01

    An X-ray microprobe for radiobiological studies was developed which deliver precise doses of radiation to the selected individual cells. The facility used synchrotron radiation as soft X-ray source. A zone plate combining with a pinhole produced a fine probe from bending magnet for single cell irradiating with defined doses. The diameter of microprobe at the target position was about 2 μm by scanning a knife-edge with an AXUV photo diode. The fluxes of soft X-rays at 516.7 eV (2.4 nm) were about 5.4×104 photons/s.100mA measured with the photo diode. The absorbed dose rate for typical yeast cells was about 11.34 Gy/s with the storage current of 100 mA. A preliminary experiment for yeast cells irradiation has shown that the microprobe had a definite biological effect for radiobiological investigations. The soft X-ray microprobe at "water window" region has provided a useful tool for single cell irradiating damage and a capability of individually irradiating a certain numbers of cells each time.

  17. Preparatory study of a ground-based space radiobiology program in Europe

    Science.gov (United States)

    Durante, M.; Kraft, G.; O'Neill, P.; Reitz, G.; Sabatier, L.; Schneider, U.

    Space radiation has long been acknowledged as a potential showstopper for long duration manned interplanetary missions. Our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. In an effort to gain more information on space radiation risk and to develop countermeasures, NASA initiated several years ago a Space Radiation Health Program, which is currently supporting biological experiments performed at the Brookhaven National Laboratory. Accelerator-based radiobiology research in the field of space radiation research is also under way in Russia and Japan. The European Space Agency (ESA) has recently established an ambitious exploration program (AURORA), and within this program it has been decided to include a space radiation research program. Europe has a long tradition in radiobiology research at accelerators, generally focussing on charged-particle cancer therapy. This expertise can be adapted to address the issue of space radiation risk. To support research in this field in Europe, ESA issued a call for tender in 2005 for a preliminary study of investigations on biological effects of space radiation (IBER). This study will provide guidance on future ESA-supported activities in space radiation research by identifying the most appropriate European accelerator facilities to be targeted for cooperation, and by drafting a roadmap for future research activities. The roadmap will include a prioritisation of research topics, and a detailed proposal for experimental campaigns for the following 5 10 years.

  18. A model to describe potential effects of chemotherapy on critical radiobiological treatments

    Science.gov (United States)

    Rodríguez-Pérez, D.; Desco, M. M.; Antoranz, J. C.

    2016-08-01

    Although chemo- and radiotherapy can annihilate tumors on their own. they are also used in coadjuvancy: improving local effects of radiotherapy using chemotherapy as a radiosensit.izer. The effects of radiotherapy are well described by current radiobiological models. The goal of this work is to describe a discrete radiotherapy model, that has been previously used describe high radiation dose response as well as unusual radio-responses of some types of tumors (e.g. prostate cancer), to obtain a model of chemo+radiotherapy that can describe how the outcome of their combination is a more efficient removal of the tumor. Our hypothesis is that, although both treatments haven different mechanisms, both affect similar key points of cell metabolism and regulation, that lead to cellular death. Hence, we will consider a discrete model where chemotherapy may affect a fraction of the same targets destroyed by radiotherapy. Although radiotherapy reaches all cells equally, chemotherapy diffuses through a tumor attaining lower concentration in its center and higher in its surface. With our simulations we study the enhanced effect of combined therapy treatment and how it depends on the tissue critical parameters (the parameters of the lion-extensive radiobiological model), the number of “targets” aimed at by chemotherapy, and the concentration and diffusion rate of the drug inside the tumor. The results show that an equivalent, cliemo-radio-dose can be computed that allows the prediction of the lower radiation dose that causes the same effect than a radio-only treatment.

  19. The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation

    International Nuclear Information System (INIS)

    Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach. 10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm3. The original 3D conformal plans (50Gy3D) were compared to newly created RapidArc plans of 50GyRA and 60GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared. There was a significant increase in NTCP of the stomach wall when moving from the 50GyRA to the 60GyRA plans (11–17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60GyRA plans. Radiobiological modelling suggests that increasing the prescribed dose to 60Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60Gy

  20. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness.

    Science.gov (United States)

    Blakely, E A; Kronenberg, A

    1998-11-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  1. Research in radiobiology: Annual report of work in progress in the internal irradiation program

    International Nuclear Information System (INIS)

    In the early 1950's the Atomic Energy Commission established at the University of Utah a large, long-term study designed to investigate the toxicity of internally deposited radionuclides in beagles. The first animals were injected on December 1, 1952 and thus began an odyssey unusual in modern science both for its duration and continued scientific interest and relevance. The original dogs were injected with 239Pu and 226Ra. Later, studies were initiated with 241Am, 249Cf, 252Cf, 253Es, 224Ra, 228Ra, 90Sr, and 228Th. These studies were unique and have and will continue to contribute valuable scientific information on the behavior and effects of these substances in biological systems. We feel that the data collected from these studies will be useful for many decades to come as we ask more demanding questions relative to radionuclides and environmental, biological and health issues. While this publication will be the last of our series Research in Radiobiology, the lifespan carcinogenesis studies are continuing under a collaborative arrangement with the I.T.R.I. Beginning in 1988, the colony status tables of dogs in the Utah studies and reports of research by the Radiobiology faculty will be included in the annual I.T.R.I. report. Under our new collaborative arrangements with the I.T.R.I. for the conduct of the lifespan carcinogenesis studies, we expect a continued high level of scientific productivity from our faculty

  2. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness.

    Science.gov (United States)

    Blakely, E A; Kronenberg, A

    1998-11-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue. PMID:9806616

  3. 武警南疆某部新兵健康教育需求调查评估%Investigation and evaluation of demands of health education in Chinese People’ s Armed Police Forces in southern Xinjiang region

    Institute of Scientific and Technical Information of China (English)

    王保平; 许德仓; 张新军; 贾涛; 朱强

    2015-01-01

    Objective To investigate and evaluate the demands of health education in Chinese People ’ s Armed Police Forces in Nanjiang region .Methods By using the method of the self-made questionnaire , The demands of health education in 480 recruits were investigated about the contents of demands of health education , the ways of health demands , the status of health knowledge-atti-tude-behavior、According to different academic diplomas and different origins , comprehensive evaluation of the demands of health edu-cation was done .Results The total rate of awareness of knowledge about health education reached 70.25%.The total rates of holding health attitude and health behavior were 88.46%and 62.35%.Demands of health education in recruits were extensive , The top five demands were as follows.self-protection against terrorism (100%), mental regulation against terrorism (100%), custom of minority area (87.95%), cold-warm knowledge in desert area (83.93%),wound ambulance (83.09%),and characteristics of desert climate (83.09%).The need of stress and social disabilities was the lowest (43.97%).Multi-media and self-study online were the favorite means of health education , accounting for 84.24%and 60.44%, respectively.There was statistically significant difference in academic diplomas and different origins in sexual physiology and psychology needs .Conclusions Self-protection against terrorism , mental regu-lation against terrorism , custom of minority area along with multi-media and self-study online are the most urgent demands .%目的:调查并评估南疆武警某部新兵的健康教育需求。方法通过自编调查问卷的方法,调查了南疆武警某部480名新兵的健康教育需求内容、健康需求方式、健康知信行现状,并按不同学历、不同户籍对新兵的健康教育需求进行综合分析、评估。结果武警南疆某部新兵健康知信行现状中健康知识总知晓率为70.25%,健康态度总持有率为88.46%

  4. 武警部队护理士官学员学习压力分析与对策研究%Analysis and countermeasures of people's armed police force nursing officer students' learning stress

    Institute of Scientific and Technical Information of China (English)

    李艳菊; 李雅平; 陈振锋

    2012-01-01

    Objective: Through the methods of questionnaire survey care pressures about the nursing officer students' feel, performance and causes, and to find effective methods and measures in order to reduce the students psychological disorders and to ensure security and stability. Methods:Using cluster sampling method, a questionnaire survey was conducted among 229 students in grade 2009 to determine their during the school's perception of stress .sources of stress, the main reason of pressure form, the adverse effects of pressure unresolved, self - resolve ways, and the objects of conversation, get someone to help the situation and find a psychiatrist to conduct. Results :229 students during the school experience greater stresses. The main source of stress was study which accounted for 86.46% ,the team event too much accounted for 46.29% , others accounted for 43.23% ,the employment accounting for 41.92%. The main reasons of the pressure formation were lack of capacity for individuals accounted for 37.12% ,fast pace of life accounted for 35.81 % ,learning competition accounted for 35.81 % ,lack of communication accounted for 29.69% and the resolve channels are poor. The stress are unsolved will affect learning,normal life and strained relations with fellow students. The ways to resolve themselves when the face of pressure to use more methods of listening music,chatting and walking. They face the pressure choice people to talk to them, the object by turns are classmates, comrades, and parents. When the face pressures to get help from team leaders are more. They was no time to find a psychiatrist and counseling agencies to resolve the pressure. Conclusion: People's Armed Police Force nursing soldier offices feel more pressure, learning is the main source of stress which should be established social support systems to reduce the adverse effects of stress,to achieve to ensure improved quality of teaching,to ensure security and stability.%目的:通过调查问卷了解护理

  5. 424名武警官兵救援创伤后成长状况的调查分析%Survey of rescue posttraumatic growth of 424 Chinese people's armed forces soldiers

    Institute of Scientific and Technical Information of China (English)

    张月娟; 王进礼; 赵蕴; 杨帆; 周喻; 孙江男; 邢宏树

    2014-01-01

    Objective To explore the status and influencing factors of the rescue posttraumatic growth of Chinese people' s armed forces soldiers in order to provide a new point of view for psychological intervention.Methods 424 soldiers who had executed earthquake rescue task were assessed with Posttraumatic Growth Inventory (PTGI),and the growth status between different groups were compared.Results (1) The average score of PTGI 21 items ranged from 2.72-3.72,and the score of most items were above 3,which implied the growth degree was between "middle change" and "more change".8 items with highest score were focused on three dimensions which were labeled interpersonal relationship,appreciation of life and personal strength.(2) There was no significant difference between the total score of different rank groups (F=0.885,P>0.05),which score were 3.43±0.66,3.50±0.62,3.50±0.79,3.30±1.11 respectively.The was significant difference in 4 dimensions and total score of PTGI between the group which had executed rescue task for more than 14 days and the other which had executed rescue task for less than 14 days,and the scores of the group which had executed rescue task for more than 14 days were higher (P<0.05 or 0.01).Conclusion Almost all rescue soldiers perceives mental growth,such as the changes of interpersonal relationship,attitude of life,and personal strength particularly.The duration of rescue task might be a influencing factor of posttraumatic growth.%目的 探讨武警官兵救援创伤后成长的状况及影响因素,为救援官兵的心理干预工作提供新的思路.方法 以创伤后成长量表PTGI为研究工具,施测于执行抗震救灾任务的424名官兵,对其成长状况进行分析并对不同群体间成长差异进行比较.结果 (1)424名被试在PTGI21个条目的平均得分在2.72~ 3.72之间,绝大部分条目平均得分在3分以上,成长程度在“变化中等(3分)”与“变化较大(4分)”之间.8个得分最高的条目分别

  6. 武警某执勤部队膳食铁与血脂水平的相关性研究%Associations between intake of dietary iron and blood lipid in soldiers of Armed Police Forces

    Institute of Scientific and Technical Information of China (English)

    楚琳; 王磊; 李严; 李卉

    2015-01-01

    Objective To investigate the associations between intake of the dietary iron and blood lipid in the soldiers of Armed Police Forces .Methods Dietary survey for 3 days by dietary weighing method was made and the total iron content , heme-iron and non heme-iron intakes were counted in 115 soldiers.Fasting total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol ( LDL-C) were also measured .Logistic regression models and one-way ANOVA were used to assess associa-tions and prevalence between the total iron content , heme-iron and non heme-iron intakes and dyslipidemia risks after adjusting for age , BMI and energy consumption .Results The average iron intake was higher than the Chinese DRIs value .The total dietary iron , heme iron and non-heme iron contents were 47.1mg, 26.5mg and 19.9mg, respectively.The total dietary iron content and heme-iron were positively associated with the blood total cholesterol ( TC) , triglycerides ( TG) , and low density lipoprotein cholesterol ( LDL-C) ( P<0.05).With increasing dietary iron content and heme-iron, dyslipidemia risks were significantly increased .Conclusion Dietary iron from animal foods may have a bad effect on the blood lipid levels .%目的:研究武警某执勤部队战士膳食铁与血脂间的关系,为进一步提供合理膳食结构、保持机体血脂代谢平衡提供理论基础。方法115名战士作为调查对象,采用3 d称重法对其食堂伙食供应情况连续调查,计算其食物总铁元素、动物来源的血红素铁及植物来源的非血红素铁摄入量;取空腹静脉血,全自动生化分析仪检测血浆总胆固醇( total cholesterol , TC)、三酰甘油(triglycerides,TG)、高密度脂蛋白胆固醇(HDL cholesterol,HDL-C)和低密度脂蛋白胆固醇(LDL cholesterol, LDL-C),采用多元回归分析食物总铁元素、动物性食物来源的血红蛋白铁,以及植物性食物来源的非血红蛋白铁摄

  7. Radiobiologically optimized couch shift: A new localization paradigm using cone-beam CT for prostate radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yimei, E-mail: yhuang2@hfhs.org; Gardner, Stephen J.; Wen, Ning; Zhao, Bo; Gordon, James; Brown, Stephen; Chetty, Indrin J. [Department of Radiation Oncology, Henry Ford Health System, 2799 W Grand Boulevard, Detroit, Michigan 48202 (United States)

    2015-10-15

    Purpose: To present a novel positioning strategy which optimizes radiation delivery by utilizing radiobiological response knowledge and evaluate its use during prostate external beam radiotherapy. Methods: Five patients with low or intermediate risk prostate cancer were evaluated retrospectively in this IRB-approved study. For each patient, a VMAT plan with one 358° arc was generated on the planning CT (PCT) to deliver 78 Gy in 39 fractions. Five representative pretreatment cone beam CTs (CBCT) were selected for each patient. The CBCT images were registered to PCT by a human observer, which consisted of an initial automated registration with three degrees-of-freedom, followed by manual adjustment for agreement at the prostate/rectal wall interface. To determine the optimal treatment position for each CBCT, a search was performed centering on the observer-matched position (OM-position) utilizing a score function based on radiobiological and dosimetric indices (EUD{sub prostate}, D99{sub prostate}, NTCP{sub rectum}, and NTCP{sub bladder}) for the prostate, rectum, and bladder. We termed the optimal treatment position the radiobiologically optimized couch shift position (ROCS-position). Results: The dosimetric indices, averaged over the five patients’ treatment plans, were (mean ± SD) 79.5 ± 0.3 Gy (EUD{sub prostate}), 78.2 ± 0.4 Gy (D99{sub prostate}), 11.1% ± 2.7% (NTCP{sub rectum}), and 46.9% ± 7.6% (NTCP{sub bladder}). The corresponding values from CBCT at the OM-positions were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.8 ± 0.7 Gy (D99{sub prostate}), 12.1% ± 5.6% (NTCP{sub rectum}), and 51.6% ± 15.2% (NTCP{sub bladder}), respectively. In comparison, from CBCT at the ROCS-positions, the dosimetric indices were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.3 ± 0.6 Gy (D99{sub prostate}), 8.0% ± 3.3% (NTCP{sub rectum}), and 46.9% ± 15.7% (NTCP{sub bladder}). Excessive NTCP{sub rectum} was observed on Patient 5 (19.5% ± 6.6%) corresponding to localization at OM

  8. Managing new arms races

    International Nuclear Information System (INIS)

    The management of new arms races in the region of Asia-Pacific includes considerations of weapons trade and transfer in the region, with an emphasis on nuclear weapons proliferation. It deals with the problem of controlling the arms trade and the efforts to control conventional weapons and underlines the possible role and influence of Conference on Cooperation and Security in Europe (CSCE)

  9. ARM Mentor Selection Process

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, D. L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-10-01

    The Atmospheric Radiation Measurement (ARM) Program was created in 1989 with funding from the U.S. Department of Energy (DOE) to develop several highly instrumented ground stations to study cloud formation processes and their influence on radiative transfer. In 2003, the ARM Program became a national scientific user facility, known as the ARM Climate Research Facility. This scientific infrastructure provides for fixed sites, mobile facilities, an aerial facility, and a data archive available for use by scientists worldwide through the ARM Climate Research Facility—a scientific user facility. The ARM Climate Research Facility currently operates more than 300 instrument systems that provide ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as lead mentors. Lead mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They must also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets. The ARM Climate Research Facility is seeking the best overall qualified candidate who can fulfill lead mentor requirements in a timely manner.

  10. Literature study of the radiobiological parameters of Caesium-137 required for evaluating internal irradiation doses as a function of age

    International Nuclear Information System (INIS)

    This document reassembles information published in scientific literature on radiobiological parameters of Cs-137, necessary for the estimate of the internal irradiation dose of man according to his age (during growth). The data are completed by a commented review of the mathematical models, proposed in order to value the irradiation doses from ingested cesium and the biological parameters. (author)

  11. Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once. (KRM)

  12. Proton Radiobiology

    OpenAIRE

    Francesco Tommasino; Marco Durante

    2015-01-01

    In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming...

  13. Proton Radiobiology

    Directory of Open Access Journals (Sweden)

    Francesco Tommasino

    2015-02-01

    Full Text Available In addition to the physical advantages (Bragg peak, the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE, protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming a fixed RBE of 1.1 for the whole radiation field. However, data emerging from recent studies suggest that, for several end points of clinical relevance, the biological response is differentially modulated by protons compared to photons. In parallel, research in the field of medical physics highlighted how variations in RBE that are currently neglected might actually result in deposition of significant doses in healthy organs. This seems to be relevant in particular for normal tissues in the entrance region and for organs at risk close behind the tumor. All these aspects will be considered and discussed in this review, highlighting how a re-discussion of the role of a variable RBE in proton therapy might be well-timed.

  14. Micro-and nanodosimetry for radiobiological planning in radiotherapy and cancer risk assessment in radiation environment

    International Nuclear Information System (INIS)

    Full text: Microdosimetry and nanodosimetry can provide unique information for prediction of radiobiological properties of radiation, which is important in radiation therapy for accurate dose planning and in radiation protection for cancer induction risk assessment. This demand measurements of the pattern of energies deposited by ionizing radiation on cellular scale and DNA levels.Silicon microelectronics technology is offering a unique opportunity for replacing gas proportional counters (TEPC) with miniature detectors for regional microdosimetry. Silicon on Insulator (SOI) technology has been used for the development of arrays of micron size sensitive volumes for modelling energy deposited in biological cells. The challenge in silicon microdosimetry is the development of well defined sensitive volume (SV) and full charge collection deposited by ionizing radiation in the SV. First generation SOI microdosimeters were developed at CMRP and investigated in a wide range of radiation fields for proton and neutron therapies and recently on isotopic neutron sources and heavy ions with energy up to lGeV/jj,m which are typical for deep space radiation environment. Microdosimetric spectra were obtained in a phantom that are well matched to TEPC and Monte Carlo simulations. Evidence that radiations with the same LET exhibit different biological effects demand development of new sensors sensitive to the track structure of ions or the type of particle for prediction of radiobiological effect of radiation using radiobiological models. New monolithic Si AE-E telescope of cellular size for simultaneous regional microdosimetry and particle identification will be presented and results will be discussed. The new design of the SOI microdosimeter is based on 3D micron and submicron size of Si SVs. This approach allows improvement in the accuracy of the Si microdosimetry because of full charge collection and the ability to measure low LET as low as 0.01 keV/jjm, which is similar to TEPC

  15. Modification of radiobiological effects of 171 MeV protons by elements of physical protection

    Science.gov (United States)

    Bulinina, Taisia; Shurshakov, Vyacheslav; Ivanov, Alexander; Molokanov, Alexander

    2016-07-01

    Space radiation includes protons of various energies. Physical protection is effective in the case of low energy protons (50-100 MeV) and becomes insufficient for radiation with a high part of high-energy protons. In the experiment performed on outbred mice, the purpose of the study was to evaluate the radiobiological effect of 171 MeV protons and protons modified by elements of physical protection of the spacecraft, on a complex of indicators of the functional condition of the system hematopoiesis and the central nervous system in 24 hours after irradiation at 20 cGy dose. The spacecraft radiation protection elements used in the experiment were a construction of wet hygiene wipes called a «protective curtain», and a glass plate imitating an ISS window. Mass thickness of the " protective curtain" in terms of water equivalent was ̴ 6,2 g/cm2. Physical shielding along the path of 171 MeV protons increases their linear energy transfer leading to the absorbed dose elevation and strengthening of the radiobiological effect. In the experiment, the two types of shielding together raised the absorbed dose from 20 to 23.2 cGy. Chemically different materials (glass and water in the wipes) were found to exert unequal modifying effects on physical and biological parameters of the proton-irradiated mice. There was a distinct dose-dependent reduction of bone marrow cellularity within the dose range from 20 cGy to 23.2 cGy in 24 hours after exposure. No modifying effect of the radiation protection elements on spontaneous motor activity was discovered when compared with entrance protons. The group of animals protected by the glass plate exhibited normal orientative-trying reactions and weakened grip with the forelimbs. The effects observed in the experiment indicate the necessity to carry out comprehensive radiobiological researches (physical, biological and mathematical) in assessing the effects of physical protection, that are actual for ensuring radiation safety of crews in

  16. Contralateral manual compensation for velocity-dependent force perturbations

    OpenAIRE

    Jackson, Carl P. T.; Miall, R. Chris

    2007-01-01

    It is not yet clear how the temporal structure of a voluntary action is coded allowing coordinated bimanual responses. This study focuses on the adaptation to and compensation for a force profile presented to one stationary arm which is proportional to the velocity of the other moving arm. We hypothesised that subjects would exhibit predictive coordinative responses which would co-vary with the state of the moving arm. Our null hypothesis is that they develop a time-dependent template of forc...

  17. Hadron Radiobiology : Investigation of the Inhibition of ten days Growth of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2 Hadron Radiobiology : Investigation of the Inhibition of ten days'Grown of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2

    CERN Multimedia

    2002-01-01

    Hadron Radiobiology : Investigation of the Inhibition of ten days Growth of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2 Hadron Radiobiology : Investigation of the Inhibition of ten days'Grown of Vicia Faba Roots after Exposure in the 600 MeV Neutron Beam from SC2

  18. Strategic forces briefing

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  19. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available   Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  20. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  1. A biomechanical analysis of the 'high guard' position of arms during walking in toddlers.

    Science.gov (United States)

    Kubo, Masayoshi; Ulrich, Beverly

    2006-12-01

    In this study, we investigated biomechanical contributions of the high guard position of the arms observed only in a subgroup of toddlers at very early stages of gait development. Six healthy toddlers who showed this peculiar arm posture were involved in this study. They participated in two data collection sessions (1 month apart). We used three-dimensional analysis of arm posture during gait to estimate the changes in forces and torques generated by the arms and acting on the upper trunk segment. Across visits, toddlers' increase in walking speeds coincided with lowering arm postures. Despite the apparent trend of changes in arm posture in this group of toddlers, the interaction between arm posture and upper trunk position created a variety of changes in forces and torques among individuals. Findings of this study exhibited an example of the exploration of dynamics by toddlers in the early stage of gait development.

  2. Hypo-fractionated treatment in radiotherapy: radio-biological models Tcp and NTCP

    International Nuclear Information System (INIS)

    At the present time the breast cancer in Mexico has the first place of incidence of the malignant neoplasia s in the women, and represents 11.34% of all the cancer cases. On the other hand, the treatments for cancer by means of ionizing radiations have been dominated under the approaches of the medical radio-oncologists which have been based on test and error by many years. The radio-biological models, as the Tcp, NTCP and dosimetric variables, for their clinical application in the conventional radiotherapy with hypo-fractionation have as purpose predicting personalized treatment plans that they present most probability of tumor control and minor probability of late reactions, becoming this way support tools in the decisions taking for the patient treatments planning of Medical Physicists and Radio-oncologists. (Author)

  3. Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiation

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, G.A.; Schubert, W.W.; Marshall, T.M. (Jet Propulsion Lab., Pasadena, CA (United States))

    1992-01-01

    The biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represents a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space. (author).

  4. Treatment plan comparison between helical tomotherapy and MLC-based IMRT using radiobiological measures

    Science.gov (United States)

    Mavroidis, Panayiotis; Costa Ferreira, Brigida; Shi, Chengyu; Lind, Bengt K.; Papanikolaou, Nikos

    2007-07-01

    The rapid implementation of advanced treatment planning and delivery technologies for radiation therapy has brought new challenges in evaluating the most effective treatment modality. Intensity-modulated radiotherapy (IMRT) using multi-leaf collimators (MLC) and helical tomotherapy (HT) are becoming popular modes of treatment delivery and their application and effectiveness continues to be investigated. Presently, there are several treatment planning systems (TPS) that can generate and optimize IMRT plans based on user-defined objective functions for the internal target volume (ITV) and organs at risk (OAR). However, the radiobiological parameters of the different tumours and normal tissues are typically not taken into account during dose prescription and optimization of a treatment plan or during plan evaluation. The suitability of a treatment plan is typically decided based on dosimetric criteria such as dose-volume histograms (DVH), maximum, minimum, mean and standard deviation of the dose distribution. For a more comprehensive treatment plan evaluation, the biologically effective uniform dose ({\\bar{\\bar{D}}}) is applied together with the complication-free tumour control probability (P+). Its utilization is demonstrated using three clinical cases that were planned with two different forms of IMRT. In this study, three different cancer types at different anatomical sites were investigated: head and neck, lung and prostate cancers. For each cancer type, a linac MLC-based step-and-shoot IMRT plan and a HT plan were developed. The MLC-based IMRT treatment plans were developed on the Philips treatment-planning platform, using the Pinnacle 7.6 software release. For the tomotherapy HiArt plans, the dedicated tomotherapy treatment planning station was used, running version 2.1.2. By using {\\bar{\\bar{D}}} as the common prescription point of the treatment plans and plotting the tissue response probabilities versus {\\bar{\\bar{D}}} for a range of prescription doses

  5. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    Science.gov (United States)

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation.

  6. Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiation

    Science.gov (United States)

    Nelson, G. A.; Schubert, W. W.; Marshall, T. M.

    1992-01-01

    The biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represent a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space.

  7. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    Science.gov (United States)

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  8. Transnational science and collaborative networks. The case of Genetics and Radiobiology in Mexico, 1950-1970.

    Science.gov (United States)

    Barahona, Ana

    2015-01-01

    The transnational approach of the science and technology studies (S&TS) abandons the nation as a unit of analysis in order to understand the development of science history. It also abandons Euro-US-centred narratives in order to explain the role of international collaborative networks and the circulation of knowledge, people, artefacts and scientific practices. It is precisely under this perspective that the development of genetics and radiobiology in Mexico shall be analyzed, together with the pioneering work of the Mexican physician-turned-geneticist Alfonso León de Garay who spent two years in the Galton Laboratory in London under the supervision of Lionel Penrose. Upon his return de Garay funded the Genetics and Radiobiology Program of the National Commission of Nuclear Energy based on local needs and the aim of working beyond geographical limitations to thus facilitate the circulation of knowledge, practices and people. The three main lines of research conducted in the years after its foundation that were in line with international projects while responding to the national context were, first, cytogenetic studies of certain abnormalities, and the cytogenetics and anthropological studies of the Olympic Games held in Mexico in 1968; second, the study of the effects of radiation on hereditary material; and third, the study of population genetics in Drosophila and in Mexican indigenous groups. The program played a key role in reshaping the scientific careers of Mexican geneticists, and in transferring locally sourced research into broader networks. This case shows the importance of international collaborative networks and circulation in the constitution of national scientific elites, and also shows the national and transnational concerns that shaped local practices.

  9. Radiobiological research for improving cancer therapy in India: rationale, problems and prospects

    International Nuclear Information System (INIS)

    Cancer is emerging as a very important health hazard in India. According to recent studies by the Indian Council of Medical Research, about 2.25 million patients are presently suffering from different types of cancer in India. Approximately one million new cases are diagnosed, and nearly 0.3 million deaths occur every year on account of this disease. About 2/3rd of the cancers are at an advanced stage at the time of diagnosis. However, the allocation of funds for healthcare in India to support the research efforts for developing more potent radio-chemotherapy protocols for cancer treatment is too little. Studies by the W.H.O. have estimated that less developed countries including India use less than 5% of world resources destined for cancer control. It follows from the above discussions that it is imperative to further encourage and diversify the radiobiological research in India. This can be achieved by creating radiobiological research facilities, mainly in all the cancer centers and post graduate medical institutions, and further expanding the upcoming laboratories in the universities such as Bikaner. Collaborative research programs between laboratories at different centers could facilitate systematic evaluation of various pharmacological agents and neutraceuticals for potential application for treatment of different cancers. Our studies on combination of radiation with temozolomide and certain adjuvants with selective effects on brain tumour cells will be very briefly discussed in this presentation. Finally the possible administrative set up and multi dimensional collaborations for cost effective utilization of existing resources to further augment radiation biology research will also be discussed

  10. Chasing Ghosts in Space Radiobiology Research: The Lost Focus on Non-Targeted Effects

    Science.gov (United States)

    Cucinotta, Francis; Saganti, Premkumar; Cacao, Eliedonna

    2016-07-01

    The doses and dose-rates of astronaut exposures to galactic cosmic rays (GCR) are accurately known, and lead to particle hits per cell nucleus from high charge and energy (HZE) particles of much less than one hit per cell per week. A large number of experiments have shown that additivity of biological effects is a valid assumption for space radiation exposures, while experiments at higher doses and dose-rates than occur in space continue to be a focus of the majority of space radiobiology research. Furthermore HZE particle exposures with mono-energetic particles manifest themselves as a mixed-radiation field due to the contributions of delta-rays and the random impact parameter of a particles track core to DNA and non-DNA targets in cells and tissues. The mixed-field manifestation of mono-energetic HZE particle exposures is well known from theoretical studies of microdosimetry and track structure. Additional mixed-field effects occur for single species experiments due to nuclear fragmentation in particle accelerator beam-lines and biological samples along with energy straggling. In contrast to these well known aspects of space radiobiology there are many open questions on the contribution of non-targeted effects to low dose and dose-rate exposures. Non-targeted effects (NTEs) include bystander effects and genomic instability, and have been shown to be the most important outstanding question for reducing uncertainties in space radiation cancer risk assessment. The dose-rate and radiation quality dependence of NTE's has not been established, while there is an over-arching need to develop 21st century experimental models of human cancer risk. We review possible mechanisms of NTE's and how new experiments to address these issues could be designed.

  11. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.

    Science.gov (United States)

    Lee, J; Siemann, D W; Koch, C J; Lord, E M

    1996-07-29

    While the potential importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been appreciated, methods for accurately quantifying the number of radiation-resistant hypoxic cells within tumors have been lacking. We have used the pentafluorinated derivative [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acet amide] of etanidazole (EF5), which binds selectively to hypoxic cells. The adducts formed between EF5 and cellular proteins in the hypoxic cells were detected using the specific monoclonal antibody (MAb), ELK3-51 conjugated to the flurochrome Cy3, and the number of hypoxic cells was quantified by flow cytometry. To verify the validity of this technique for the detection of hypoxic cells, mice bearing KHT sarcomas were treated with various agents to alter tumor oxygenation and hence vary the fraction of radiobiologically hypoxic tumor cells. The percentage of EF5 binding cells was then compared directly with the clonogenic survival of the tumor cells following radiation treatment under the various pretreatment conditions. The results showed that allowing the mice to breathe carbogen (5% CO2/95% O2) prior to irradiation reduced clonogenic cell survival approx. 6-fold and led to an absence of cells binding high levels of EF5. In contrast, pretreating the tumor-bearing animals with either hydralazine, which decreased tumor blood flow, or phenylhydrazine hydrochloride, which made the mice anemic, increased tumor cell survival following irradiation 2- to 4-fold, indicative of an increase in the fraction of hypoxic tumor cells. EF5 measurements made under identical conditions illustrated a shift in the cells in the tumor to high EF5 binding. Our results demonstrate that flow cytometric measurement by fluorescent MAb binding to EF5 adducts may relate directly to radiobiological hypoxia in KHT tumors measured by conventional methods. PMID:8707411

  12. Design and Implementation of Telemedicine Net Platform by Using the Armed Police Forces' Video Conferencing System%依托武警部队视频会议系统的远程医学网平台设计与实现

    Institute of Scientific and Technical Information of China (English)

    温剑; 胡永峰

    2011-01-01

    Objective To promote the telemedicine by using the computer technology and the modern communications technology in order to improve the remote areas officers' medical service support in ihe Armed Police Forces. Methods Distance medical nets hardware platform of the Level 3 distance medical center network was build which relies on the Armed Police Forces video conferencing system and the questions around the technical framework, the mean characteristics and the key technology were explained. Results The video conferencing system was use to build a telemedicine net hardware platform which would help to promote the telemedicine consultation. CnnrJiurinn Telemedicine service based on ihe present video conferencing system improves the army's medical support ability.[Chinese Medical Equipment Journal,2011 ,32(10) ? 70-71]%目的:利用计算机技术与现代通讯技术开展远程医学,进一步改善武警部队边远地区官兵的医疗卫勤保障.方法:依托武警部队视频会议系统构建三级远程医学中心组网的远程医学网硬件平台,并对平台设计与实施过程中的技术架构、主要特点、关键技术等若干问题进行分析.结果:能够实现依托视频会议系统,建成远程医学网硬件平台,开展远程医学会诊.结论:通过现有的视频会议系统,开展远程医疗服务,提高部队卫勤保障能力.

  13. ARM7-kehityskortti

    OpenAIRE

    Kukkonen, Henri

    2006-01-01

    Tämän opinnäytetyön tarkoituksena oli suunnitella ja toteuttaa ARM-mikro-ohjain pohjainen kehityskortti. Kortin tuli olla soveltuva ARM-ohjelmoinnin opettamiseen. Työssä myös selvitettiin ARM-mikro-ohjaimen ohjelmointiympäristön käyttöönotto. Teoriaosassa käsitellään ARM-arkkitehtuuria, työssä käytettyjen Atmelin AT91R40008-mikro-ohjaimen sekä Philipsin LPC2105-mikro-ohjaimen ominaisuuksia. Erityisesti työssä keskitytään kehityskorttien suunnitteluun. Kehityskortin vaatimuksina oli, että se ...

  14. Report on the behalf of Commission for National Defence and Armed Forces on the bill project (nr 1365) aiming at strengthening conditions of access to nuclear base installations (INB). Nr 2527

    International Nuclear Information System (INIS)

    This report first outlines that nuclear installations are subject to illegal intrusions which challenge their safety and security. It outlines that these installations are extremely sensitive and particularly threatened (the energy sector, as a key sector, is submitted to a specific regulation, and threats are potentially serious), that, beyond the terrorist threat and the risk of sabotage, nuclear installations are regularly facing other illegal behaviours (illegal intrusions are a recurrent issue, and drones are emerging as a new kind of threat), that the protection of nuclear installations is carried out by forces dedicated to this mission (a specialised military force for EDF sites, civil forces for the CEA and Areva, the role of the French Air Force to protect airspace), and that recent legal advances must be deepened. The second part outlines that the present legal protection framework in inadequate and incomplete. The French legal regime is presented and some foreign examples are evoked, and the need of creation of a specific penal regime is outlined. The general discussion and the discussion of the bill project articles are reported. A table proposes a comparative overview between the existing arrangement, the bill project text, and the Commission's text

  15. Documenting the Effects of Armed Conflict on Population Health.

    Science.gov (United States)

    Levy, Barry S; Sidel, Victor W

    2016-01-01

    War and other forms of armed conflict have profound adverse effects on population health. It is important to document these effects to inform the general public and policy makers about the consequences of armed conflict, provide services to meet the needs of affected populations, protect human rights and document violations of international humanitarian law, and help to prevent future armed conflict. Documentation can be accomplished with surveillance, epidemiological surveys, and rapid assessment. Challenges include inadequate or absent data systems, social breakdown, forced migration, reporting biases, and the fog of war. The adverse effects of the Iraq War on population health demonstrate how the effects of armed conflict on population health can be documented. We recommend the establishment of an independent mechanism, operated by the United Nations or a multilateral organization, to investigate and document the effects of armed conflict on population health. PMID:26989827

  16. Hello to Arms

    Science.gov (United States)

    2005-01-01

    This image highlights the hidden spiral arms (blue) that were discovered around the nearby galaxy NGC 4625 by the ultraviolet eyes of NASA's Galaxy Evolution Explorer. The image is composed of ultraviolet and visible-light data, from the Galaxy Evolution Explorer and the California Institute of Technology's Digitized Sky Survey, respectively. Near-ultraviolet light is colored green; far-ultraviolet light is colored blue; and optical light is colored red. As the image demonstrates, the lengthy spiral arms are nearly invisible when viewed in optical light while bright in ultraviolet. This is because they are bustling with hot, newborn stars that radiate primarily ultraviolet light. The youthful arms are also very long, stretching out to a distance four times the size of the galaxy's core. They are part of the largest ultraviolet galactic disk discovered so far. Located 31 million light-years away in the constellation Canes Venatici, NGC 4625 is the closest galaxy ever seen with such a young halo of arms. It is slightly smaller than our Milky Way, both in size and mass. However, the fact that this galaxy's disk is forming stars very actively suggests that it might evolve into a more massive and mature galaxy resembling our own. The armless companion galaxy seen below NGC 4625 is called NGC 4618. Astronomers do not know why it lacks arms but speculate that it may have triggered the development of arms in NGC 4625.

  17. Two-Armed, Mobile, Sensate Research Robot

    Science.gov (United States)

    Engelberger, J. F.; Roberts, W. Nelson; Ryan, David J.; Silverthorne, Andrew

    2004-01-01

    contains a force-and-torque sensor that provides feedback for force (compliance) control of the arm. The end effector could be a tool or a robot hand, depending on the application.

  18. The objective qualification of non-international armed conflicts: A Colombian case study

    OpenAIRE

    Sebastian Machado; Guillermo Otálora Lozano

    2012-01-01

    Armed conflict has raged in Colombia since at least the 1960’s, involving governmental forces, rebel groups, and paramilitary forces. The Uribe government (2002-2010) declared that Colombia was not in a ‘state of armed conflict’ but was rather facing a ‘terrorist threat’. This declaration was done in fear of conferring a political status to the armed groups, and most particularly, in fear that a recognition of armed conflict would open the possibility of endowing the Revolutionary Ar...

  19. Development of a multisensory arm for process monitoring in Robot Assisted Polishing

    DEFF Research Database (Denmark)

    Pilny, Lukas; Dalla Costa, Giuseppe; Bissacco, Giuliano;

    Robot Assisted Polishing (RAP) process is capable of achieving surface roughness down to Sa 10 nm on industrial components. In RAP, a robot arm carries a polishing module with controlled contact force utilizing oscillating or rotating tools. In this work a multisensory polishing arm with integrated...... Acoustic Emission (AE), accelerometer and force sensors was developed and the reliability of force measurements for process monitoring in RAP was verified....

  20. Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints

    International Nuclear Information System (INIS)

    Today there is general awareness of the potential damage to the heart in left-sided (more than in right-sided) breast cancer radiotherapy (RT). Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Individual and pharmacological risk factors are also examined with respect to radiation damage. The biological mechanisms of harm are only partially understood, such as the radiobiology of heart damage due to the presence of various radiosensitive structures and their topographic heterogeneity. Furthermore, individual variability may expose patients to higher or lower risks of late cardiac damage or death. Damage mechanisms and radiobiological characteristics in heart irradiation are presented in relation to dosimetric and biological parameters.

  1. Optimization in brachytherapy with the implementation of Radiobiology; Optimizacion en Braquiterapia con la implementacion de la Radiobiologia

    Energy Technology Data Exchange (ETDEWEB)

    Duran, M.P.; Bourel, V.J.; Rodriguez, I.; Torre, M. de la; Caneva, S. [Braqui S.R.L. Viamonte 1861, Buenos Aires (Argentina)

    1998-12-31

    In the brachytherapy planning treatments with High dose rates (HDR), the optimization algorithms used are based in dosimetric considerations and/or geometric ones, ignoring the radiobiological response of the tissue treated. In this work we wish to show the implementation of radiobiological concepts in the optimization. Assuming that the subtiles differences that result in the dose distribution among the different optimization models which are not visible in an isodose plane, it is studied how is classically make it , the quality implant through natural histograms about dose volumes and the resulting parameters. Also is studied the necrosis probability which may be caused by the choice of some optimization model, allowing with this the choice of the best implant. (Author)

  2. Octopus-inspired multi-arm robotic swimming.

    Science.gov (United States)

    Sfakiotakis, M; Kazakidi, A; Tsakiris, D P

    2015-05-13

    The outstanding locomotor and manipulation characteristics of the octopus have recently inspired the development, by our group, of multi-functional robotic swimmers, featuring both manipulation and locomotion capabilities, which could be of significant engineering interest in underwater applications. During its little-studied arm-swimming behavior, as opposed to the better known jetting via the siphon, the animal appears to generate considerable propulsive thrust and rapid acceleration, predominantly employing movements of its arms. In this work, we capture the fundamental characteristics of the corresponding complex pattern of arm motion by a sculling profile, involving a fast power stroke and a slow recovery stroke. We investigate the propulsive capabilities of a multi-arm robotic system under various swimming gaits, namely patterns of arm coordination, which achieve the generation of forward, as well as backward, propulsion and turning. A lumped-element model of the robotic swimmer, which considers arm compliance and the interaction with the aquatic environment, was used to study the characteristics of these gaits, the effect of various kinematic parameters on propulsion, and the generation of complex trajectories. This investigation focuses on relatively high-stiffness arms. Experiments employing a compliant-body robotic prototype swimmer with eight compliant arms, all made of polyurethane, inside a water tank, successfully demonstrated this novel mode of underwater propulsion. Speeds of up to 0.26 body lengths per second (approximately 100 mm s(-1)), and propulsive forces of up to 3.5 N were achieved, with a non-dimensional cost of transport of 1.42 with all eight arms and of 0.9 with only two active arms. The experiments confirmed the computational results and verified the multi-arm maneuverability and simultaneous object grasping capability of such systems.

  3. DEGRO practical guidelines for radiotherapy of non-malignant disorders. Part I: physical principles, radiobiological mechanisms, and radiogenic risk

    International Nuclear Information System (INIS)

    Synopsis of the introductory paragraph of the DEGRO consensus S2e-guideline recommendations for the radiotherapy of benign disorders, including physical principles, radiobiological mechanisms, and radiogenic risk. This work is based on the S2e-guideline recommendations published November 14, 2013. The basic principles of radiation physics and treatment delivery, evaluation of putative underlying radiobiological mechanisms, and the assessment of genetic and cancer risk following low-dose irradiation will be presented. Radiation therapy of benign diseases is performed according to similar physical principles as those governing treatment of malignant diseases in radiation oncology, using the same techniques and workflows. These methods comprise usage of orthovoltage X-ray units, gamma irradiation facilities, linear accelerators (LINACs), and brachytherapy. Experimental in vitro and in vivo models recently confirmed the clinically observed anti-inflammatory effect of low-dose X-irradiation, and implicated a multitude of radiobiological mechanisms. These include modulation of different immunological pathways, as well as the activities of endothelial cells, mono- and polymorphonuclear leukocytes, and macrophages. The use of effective dose for radiogenic risk assessment and the corresponding tumor incidence rate of 5.5 %/Sv are currently controversially discussed. Some authors argue that the risk of radiation-induced cancers should be estimated on the basis of epidemiological data. However, such data are rarely available at present and associated with high variability. Current radiobiological studies clearly demonstrate a therapeutic effectiveness of radiation therapy used to treat benign diseases and implicate various molecular mechanisms. Radiogenic risks should be taken into account when applying radiation treatment for benign diseases. (orig.)

  4. Relationships Between Rectal Wall Dose-Volume Constraints and Radiobiologic Indices of Toxicity for Patients With Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: The purpose of this article was to investigate how exceeding specified rectal wall dose-volume constraints impacts on the risk of late rectal bleeding by using radiobiologic calculations. Methods and Materials: Dose-volume histograms (DVH) of the rectal wall of 250 patients with prostate cancer were analyzed. All patients were treated by three-dimensional conformal radiation therapy, receiving mean target doses of 80 Gy. To study the main features of the patient population, the average and the standard deviation of the distribution of DVHs were generated. The mean dose , generalized equivalent uniform dose formulation (gEUD), modified equivalent uniform dose formulation (mEUD)0, and normal tissue complication probability (NTCP) distributions were also produced. The DVHs set was then binned into eight classes on the basis of the exceeding or the fulfilling of three dose-volume constraints: V40 = 60%, V50 = 50%, and V70 = 25%. Comparisons were made between them by , gEUD, mEUD0, and NTCP. Results: The radiobiologic calculations suggest that late rectal toxicity is mostly influenced by V70. The gEUD and mEUD0 are risk factors of toxicity always concordant with NTCP, inside each DVH class. The mean dose, although a reliable index, may be misleading in critical situations. Conclusions: Both in three-dimensional conformal radiation therapy and particularly in intensity-modulated radiation therapy, it should be known what the relative importance of each specified dose-volume constraint is for each organ at risk. This requires a greater awareness of radiobiologic properties of tissues and radiobiologic indices may help to gradually become aware of this issue

  5. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    OpenAIRE

    Beyreuther, Elke

    2010-01-01

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent t...

  6. Phoenix Stretches its Arm

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation The Phoenix spacecraft is scheduled to begin raising its robotic arm up and out of its stowed configuration on the third Martian day, or Sol 3 (May 28, 2008) of the mission. This artist's animation, based on engineering models, shows how Phoenix will accomplish this task. First, its wrist actuator will rotate, releasing its launch-restraint pin. Next, the forearm moves up, releasing the elbow launch-restraint pin. The elbow will then move up and over in small steps, a process referred to as 'staircasing.' This ensures that the arm's protective biobarrier wrap, now unpeeled and lying to the side of the arm, will not get in the way of the arm's deployment. The arm is scheduled to straighten all the way out on Sol 4 (May 29, 2008), after engineers have reviewed images and telemetry data from the spacecraft showing that the biobarrier material has been cleared. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  7. Contamination and incorporation due to emission of ionizing radiation from radar equipment of the German Federal Armed Forces. A reply to the report of the staff working group Dr. Sommer, presented 21st June 2001. 2. rev. ed.

    International Nuclear Information System (INIS)

    The document refers to an issue of public debate in Germany, induced by the disclosure of inappropriate occupational safety measures at radar equipment of the German Army and Air Force. In this reply to the official report of investigation, the author gives his own expert opinion, discussing health risks in connection with radar equipment in general, and the specific military radar installations in particular. The author explains his approach to assessing the occupational radiation dose to military personnel and the resulting health risks and effects in that particular case. (orig./CB)

  8. A study of the radiobiological modeling of the conformal radiation therapy in cancer treatment

    Science.gov (United States)

    Pyakuryal, Anil Prasad

    Cancer is one of the leading causes of mortalities in the world. The precise diagnosis of the disease helps the patients to select the appropriate modality of the treatments such as surgery, chemotherapy and radiation therapy. The physics of X-radiation and the advanced imaging technologies such as positron emission tomography (PET) and computed tomography (CT) plays an important role in the efficient diagnosis and therapeutic treatments in cancer. However, the accuracy of the measurements of the metabolic target volumes (MTVs) in the PET/CT dual-imaging modality is always limited. Similarly the external beam radiation therapy (XRT) such as 3D conformal radiotherapy (3DCRT) and intensity modulated radiation therapy (IMRT) is the most common modality in the radiotherapy treatment. These treatments are simulated and evaluated using the XRT plans and the standard methodologies in the commercial planning system. However, the normal organs are always susceptible to the radiation toxicity in these treatments due to lack of knowledge of the appropriate radiobiological models to estimate the clinical outcomes. We explored several methodologies to estimate MTVs by reviewing various techniques of the target volume delineation using the static phantoms in the PET scans. The review suggests that the more precise and practical method of delineating PET MTV should be an intermediate volume between the volume coverage for the standardized uptake value (SUV; 2.5) of glucose and the 50% (40%) threshold of the maximum SUV for the smaller (larger) volume delineations in the radiotherapy applications. Similarly various types of optimal XRT plans were designed using the CT and PET/CT scans for the treatment of various types of cancer patients. The qualities of these plans were assessed using the universal plan-indices. The dose-volume criteria were also examined in the targets and organs by analyzing the conventional dose-volume histograms (DVHs). The biological models such as tumor

  9. Radiobiological evaluation of intensity modulated radiation therapy treatments of patients with head and neck cancer: A dual-institutional study

    Directory of Open Access Journals (Sweden)

    G Narayanasamy

    2015-01-01

    Full Text Available In clinical practice, evaluation of clinical efficacy of treatment planning stems from the radiation oncologist's experience in accurately targeting tumors, while keeping minimal toxicity to various organs at risk (OAR involved. A more objective, quantitative method may be raised by using radiobiological models. The purpose of this work is to evaluate the potential correlation of OAR-related toxicities to its radiobiologically estimated parameters in simultaneously integrated boost (SIB intensity modulated radiation therapy (IMRT plans of patients with head and neck tumors at two institutions. Lyman model for normal tissue complication probability (NTCP and the Poisson model for tumor control probability (TCP models were used in the Histogram Analysis in Radiation Therapy (HART analysis. In this study, 33 patients with oropharyngeal primaries in the head and neck region were used to establish the correlation between NTCP values of (a bilateral parotids with clinically observed rates of xerostomia, (b esophagus with dysphagia, and (c larynx with dysphagia. The results of the study indicated a strong correlation between the severity of xerostomia and dysphagia with Lyman NTCP of bilateral parotids and esophagus, respectively, but not with the larynx. In patients without complications, NTCP values of these organs were negligible. Using appropriate radiobiological models, the presence of a moderate to strong correlation between the severities of complications with NTCP of selected OARs suggested that the clinical outcome could be estimated prior to treatment.

  10. Collimator design for spatially-fractionated proton beams for radiobiology research

    Science.gov (United States)

    Lee, Eunsin; Meyer, Juergen; Sandison, George

    2016-07-01

    Preclinical and translational research is an imperative to improve the efficacy of proton radiotherapy. We present a feasible and practical method to produce spatially-modulated proton beams for cellular and small animal research for clinical and research facilities. The University of Washington (UW) 50.5 MeV proton research beamline hosting a brass collimation system was modeled using Monte Carlo simulations. This collimator consisted of an array of 2 cm long slits to cover an area of 2  ×  2 cm2. To evaluate the collimator design effects on dose rate, valley dose and the peak-to-valley dose ratios (PVDR) the following parameters were varied; slit width (0.1–1.0 mm), peak center-to-center distance (1–3 mm), collimator thickness (1–7 cm) and collimator location along the beam axis. Several combinations of slit widths and 1 mm spacing achieved uniform dose at the Bragg peak while maintaining spatial modulation on the beam entrance. A more detailed analysis was carried out for the case of a slit width of 0.3 mm, peak center-to-center distance of 1 mm, a collimator thickness of 5 cm and with the collimator flush against the water phantom. The dose rate at 5 mm depth dropped relative to an open field by a factor of 12 and produced a PVDR of 10.1. Technical realization of proton mini-beams for radiobiology small animal research is demonstrated to be feasible. It is possible to obtain uniform dose at depth while maintaining reasonable modulation at shallower depths near the beam entrance. While collimator design is important the collimator location has a strong influence on the entrance region PVDRs and on dose rate. These findings are being used to manufacture a collimator for installation on the UW cyclotron proton beam nozzle. This collimator will enable comparative studies on the radiobiological efficacy of x-rays and proton beams.

  11. A comparative analysis of radiobiological models for cell surviving fractions at high doses.

    Science.gov (United States)

    Andisheh, B; Edgren, M; Belkić, Dž; Mavroidis, P; Brahme, A; Lind, B K

    2013-04-01

    For many years the linear-quadratic (LQ) model has been widely used to describe the effects of total dose and dose per fraction at low-to-intermediate doses in conventional fractionated radiotherapy. Recent advances in stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) have increased the interest in finding a reliable cell survival model, which will be accurate at high doses, as well. Different models have been proposed for improving descriptions of high dose survival responses, such as the Universal Survival Curve (USC), the Kavanagh-Newman (KN) and several generalizations of the LQ model, e.g. the Linear-Quadratic-Linear (LQL) model and the Pade Linear Quadratic (PLQ) model. The purpose of the present study is to compare a number of models in order to find the best option(s) which could successfully be used as a fractionation correction method in SRT. In this work, six independent experimental data sets were used: CHOAA8 (Chinese hamster fibroblast), H460 (non-small cell lung cancer, NSLC), NCI-H841 (small cell lung cancer, SCLC), CP3 and DU145 (human prostate carcinoma cell lines) and U1690 (SCLC). By detailed comparisons with these measurements, the performance of nine different radiobiological models was examined for the entire dose range, including high doses beyond the shoulder of the survival curves. Using the computed and measured cell surviving fractions, comparison of the goodness-of-fit for all the models was performed by means of the reduced χ (2)-test with a 95% confidence interval. The obtained results indicate that models with dose-independent final slopes and extrapolation numbers generally represent better choices for SRT. This is especially important at high doses where the final slope and extrapolation numbers are presently found to play a major role. The PLQ, USC and LQL models have the least number of shortcomings at all doses. The extrapolation numbers and final slopes of these models do not depend on dose. Their asymptotes

  12. Arm To Arm Interface Using Embedded C

    Directory of Open Access Journals (Sweden)

    Mohanraj.C

    2013-02-01

    Full Text Available Embedded systems are the most emerging field in these recent years. In this paper a different number of ARM processors (LPC2148 and LPC2378 are interconnected using C for distributed services. N numbers of processors are connected as the network and each processing devices are interlinked with each other, so that the each data that is processed by the devices and it can be used by the other device to activate their entire process. All the processed data’s are communicated to other device through Xbee interface card. LPC2148 and LPC2378 ARM processors are used in this prototype and winXtalk is used as a software terminal window. In this paper, the ultimate benefits of multiple processor interactions related to the embedded applications and design issues of processor interconnection are discussed. The features of multiple processor interaction in inter process communication and executions of embedded multitasking are also discussed. In modern embedded computing platform, embedded processor used in various applications like home automation, industrial control, medical system, access control, etc. In this paper, using embedded processor interactions, the several data communication is established.

  13. PHENIX Muon Arms

    International Nuclear Information System (INIS)

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons (∼10-3). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described

  14. PHENIX Muon Arms

    Energy Technology Data Exchange (ETDEWEB)

    Akikawa, H.; Al-Jamel, A.; Archuleta, J.B.; Archuleta, J.R.; Armendariz, R.; Armijo, V.; Awes, T.C.; Baldisseri, A.; Barker, A.B.; Barnes, P.D.; Bassalleck, B.; Batsouli, S.; Behrendt, J.; Bellaiche, F.G.; Bland, A.W.; Bobrek, M.; Boissevain, J.G.; Borel, H.; Brooks, M.L.; Brown, A.W.; Brown, D.S.; Bruner, N.; Cafferty, M.M.; Carey, T.A.; Chai, J.-S.; Chavez, L.L.; Chollet, S.; Choudhury, R.K.; Chung, M.S.; Cianciolo, V.; Clark, D.J.; Cobigo, Y.; Dabrowski, C.M.; Debraine, A.; DeMoss, J.; Dinesh, B.V.; Drachenberg, J.L.; Drapier, O.; Echave, M.A.; Efremenko, Y.V.; En' yo, H.; Fields, D.E.; Fleuret, F.; Fried, J.; Fujisawa, E.; Funahashi, H.; Gadrat, S.; Gastaldi, F.; Gee, T.F.; Glenn, A.; Gogiberidze, G.; Gonin, M.; Gosset, J.; Goto, Y.; Granier de Cassagnac, R.; Hance, R.H.; Hart, G.W.; Hayashi, N.; Held, S.; Hicks, J.S.; Hill, J.C.; Hoade, R.; Hong, B.; Hoover, A.; Horaguchi, T.; Hunter, C.T.; Hurst, D.E.; Ichihara, T.; Imai, K.; Isenhower, L.D.L. Davis; Isenhower, L.D.L. Donald; Ishihara, M.; Jang, W.Y.; Johnson, J.; Jouan, D.; Kamihara, N.; Kamyshkov, Y.; Kang, J.H.; Kapoor, S.S.; Kim, D.J.; Kim, D.-W.; Kim, G.-B.; Kinnison, W.W.; Klinksiek, S.; Kluberg, L.; Kobayashi, H.; Koehler, D.; Kotchenda, L.; Kuberg, C.H.; Kurita, K.; Kweon, M.J.; Kwon, Y.; Kyle, G.S.; LaBounty, J.J.; Lajoie, J.G.; Lee, D.M.; Lee, S.; Leitch, M.J.; Li, Z.; Liu, M.X.; Liu, X.; Liu, Y.; Lockner, E.; Lopez, J.D.; Mao, Y.; Martinez, X.B.; McCain, M.C.; McGaughey, P.L.; Mioduszewski, S.; Mischke, R.E.; Mohanty, A.K.; Montoya, B.C.; Moss, J.M.; Murata, J.; Murray, M.M.; Nagle, J.L.; Nakada, Y.; Newby, J.; Obenshain, F.; Palounek, A.P.T.; Papavassiliou, V.; Pate, S.F.; Plasil, F.; Pope, K.; Qualls, J.M.; Rao, G.; Read, K.F. E-mail: readkf@ornl.gov; Robinson, S.H.; Roche, G.; Romana, A.; Rosnet, P.; Roth, R.; Saito, N.; Sakuma, T.; Sandhoff, W.F.; Sanfratello, L.; Sato, H.D.; Savino, R.; Sekimoto, M.; Shaw, M.R.; Shibata, T.-A.; Sim, K.S.; Skank, H.D.; Smith, D.E.; Smith, G.D. [and others

    2003-03-01

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons ({approx}10{sup -3}). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described.

  15. Report on the behalf of the Commission for Foreign Affairs, Defence and Armed Forces on the bill proposition adopted by the National Assembly, related on the strengthening of the protection of civil installations containing nuclear materials. Nr 446

    International Nuclear Information System (INIS)

    In its first part, this report presents the nuclear sector as a sensitive sector under strict surveillance: a sector of critical importance (safety policy with its actors and its multi-level planning, a safety arrangement for the nuclear energy sector), a regulation specific to the nuclear sector, and specialised protection forces. It also addresses the issues of intrusions and over-flights (overview of intrusions, unsuitable penal repression, and new dimension of air safety due to the development of civil uses of drones). The next part comments the content of the bill proposition, and addresses the lack of a suitable penal regime for the protection of nuclear materials and of areas regarding defence. The scope of application of the bill proposition is discussed, as well as the applicable and additional penalties. A list of hearings is provided as well as non adopted amendments and a table proposing a comparison between different versions of the text

  16. Dosimetric measurements and radiobiological consequences of radioimmunotherapy in tumor bearing mice

    International Nuclear Information System (INIS)

    With the development of the hybridoma technology, the production of highly specific tumor associated monoclonal antibodies has provided new optimism for the adjuvant delivery of therapeutic radiation doses via radioimmunotherapy. The authors have used a modified form of the well-established TL dosimetry technology to measure the dose resulting from radioimmunotherapy experiments in tumor bearing mice. Their laboratory has designed and tested a miniature CaSO4:D TLD which fits conveniently inside a 20 gauge needle for the direct implantation of the dosimeter in an animal model undergoing radiolabeled antibody therapy. Direct measurement of absorbed dose from beta and gamma radiation in the animals may be obtained upon removal of the dosimeter at animal sacrifice or by surgery. This absorbed dose data may then be related to antibody affinity and localization data obtained by serial biodistribution studies. Using p96.5 melanoma antibody with a Brown Tumor Model in athymic mice, localization indices measured in the range of 2 to 4 and scored 4 to 7 days post antibody injection, yielded a tumor dose/whole body dose ratio of 1.10 +/- 0.04 (no enhancement). The dose to liver showed marker time-dependent enhancement relative to the whole body, however. An outline of suggested control radiobiological experiments to be performed in conjunction with radioimmunotherapy experiments has been included in order to provide comparative dose response data. 11 references, 14 figures, 3 tables

  17. Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer

    Directory of Open Access Journals (Sweden)

    Marcu Loredana

    2009-01-01

    Full Text Available Head and neck cancer represents a challenge for radiation oncologists due to accelerated repopulation of cancer cells during treatment. This study aims to simulate, using Monte Carlo methods, the response of a virtual head and neck tumor to both conventional and altered fractionation schedules in radiotherapy when accelerated repopulation is considered. Although clinical trials are indispensable for evaluation of novel therapeutic techniques, they are time-consuming processes which involve many complex and variable factors for success. Models can overcome some of the limitations encountered by trials as they are able to simulate in less complex environment tumor cell kinetics and dynamics, interaction processes between cells and ionizing radiation and their outcome. Conventional, hyperfractionated and accelerated treatment schedules have been implemented in a previously developed tumor growth model which also incorporates tumor repopulation during treatment. This study focuses on the influence of three main treatment-related parameters, dose per fraction, inter fraction interval and length of treatment gap and gap timing based on RTOG trial data on head and neck cancer, on tumor control. The model has shown that conventionally fractionated radiotherapy is not able to eradicate the stem population of the tumor. Therefore, new techniques such as hyperfractionated/ accelerated radiotherapy schedules should be employed. Furthermore, the correct selection of schedule-related parameters (dose per fraction, time between fractions, treatment gap scheduling is crucial in overcoming accelerated repopulation. Modeling of treatment regimens and their input parameters can offer better understanding of the radiobiological interactions and also treatment outcome.

  18. Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer.

    Science.gov (United States)

    Marcu, Loredana G; Bezak, Eva

    2009-10-01

    Head and neck cancer represents a challenge for radiation oncologists due to accelerated repopulation of cancer cells during treatment. This study aims to simulate, using Monte Carlo methods, the response of a virtual head and neck tumor to both conventional and altered fractionation schedules in radiotherapy when accelerated repopulation is considered. Although clinical trials are indispensable for evaluation of novel therapeutic techniques, they are time-consuming processes which involve many complex and variable factors for success. Models can overcome some of the limitations encountered by trials as they are able to simulate in less complex environment tumor cell kinetics and dynamics, interaction processes between cells and ionizing radiation and their outcome. Conventional, hyperfractionated and accelerated treatment schedules have been implemented in a previously developed tumor growth model which also incorporates tumor repopulation during treatment. This study focuses on the influence of three main treatment-related parameters, dose per fraction, inter fraction interval and length of treatment gap and gap timing based on RTOG trial data on head and neck cancer, on tumor control. The model has shown that conventionally fractionated radiotherapy is not able to eradicate the stem population of the tumor. Therefore, new techniques such as hyperfractionated/ accelerated radiotherapy schedules should be employed. Furthermore, the correct selection of schedule-related parameters (dose per fraction, time between fractions, treatment gap scheduling) is crucial in overcoming accelerated repopulation. Modeling of treatment regimens and their input parameters can offer better understanding of the radiobiological interactions and also treatment outcome.

  19. Impact of microgravity on radiobiological processes and efficiency of DNA repair

    Energy Technology Data Exchange (ETDEWEB)

    Horneck, G. [Radiation Biology Division, Institute of Aerospace Medicine, DLR German Aerospace Center, Linder Hohe, 51170 Cologne (Germany)

    1999-12-06

    To study the influence of microgravity on radiobiological processes in space, space experiments have been performed, using an on-board 1xg reference centrifuge as in-flight control. The trajectory of individual heavy ions was localized in relation to the biological systems by use of the Biostack concept, or an additional high dose of radiation was applied either before the mission or during the mission from an on-board radiation source. In embryonic systems, such as early developmental stages of Drosophila melanogaster and Carausius morosus, the occurrence of chromosomal translocations and larval malformations was dramatically increased in response to microgravity and radiation. It has been hypothesized that these synergistic effects might be caused by an interference of microgravity with DNA repair processes. However, recent studies on bacteria, yeast cells and human fibroblasts suggest that a disturbance of cellular repair processes in the microgravity environment might not be a complete explanation for the reported synergism of radiation and microgravity. As an alternative explanation, an impact of microgravity on signal transduction, on the metabolic/physiological state or on the chromatin structure at the cellular level, or modification of self-assembly, intercellular communication, cell migration, pattern formation or differentiation at the tissue and organ level should be considered.

  20. Postoperative radiotherapy in DBCG during 30 years. Techniques, indications and clinical radiobiological experience

    Energy Technology Data Exchange (ETDEWEB)

    Overgaard, Marie; Juul Christensen, Jens (Dept. of Oncology and Dept. of Medical Physics, Aarhus Univ. Hospital, Aarhus (Denmark))

    2008-05-15

    During the time period 1977-2007 postoperative radiotherapy in DBCG has varied considerably with regard to techniques and indications together with changes in the extent of surgery and adjuvant systemic therapy. The radiation treatment has been developed on the basis of clinical, radiophysical and radiobiological principles, encompassing also practical problems such as available equipment in the different centres and at times lack of sufficient machine capacity. The paper focus especially on the comprehensive work done prior to the DBCG 82 b and c studies, in order to optimize radiotherapy in all aspects prior to the evaluation of the efficacy of this treatment modality. The results from these trials did succeed in clear evidence that radiotherapy has an important role in the multidisciplinary treatment of early breast cancer. In parallel to these studies a new and challenging use of radiotherapy after breast conserving surgery was evaluated in the DBCG TM 82 protocol. The experience obtained with different techniques in this study formed the basis for the current principles of radiotherapy after lumpectomy. Reduction of radiation related morbidity has been a major issue for the DBCG radiotherapy group, and in this aspect several studies, including quality control visits, have been carried out to make the relevant modifications and to evaluate deviations from the guidelines between the centres. The background for the changes in radiotherapy is described for each of the programme periods as well as future perspectives which will include further refinements of the target and adjustments of dose and fractionation in selected patients

  1. Radiobiology of Small Hive Beetle (Coleoptera: Nitidulidae) and Prospects for Management Using Sterile Insect Releases.

    Science.gov (United States)

    Downey, Danielle; Chun, Stacey; Follett, Peter

    2015-06-01

    Small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is considered a serious threat to beekeeping in the Western Hemisphere, Australia, and Europe mainly due to larval feeding on honey, pollen, and brood of the European honeybee, Apis mellifera L. Control methods are limited for this pest. Studies were conducted to provide information on the radiobiology of small hive beetle and determine the potential for sterile insect releases as a control strategy. Adult males and females were equally sensitive to a radiation dose of 80 Gy and died within 5-7 d after treatment. In reciprocal crossing studies, irradiation of females only lowered reproduction to a greater extent than irradiation of males only. For matings between unirradiated males and irradiated females, mean reproduction was reduced by >99% at 45 and 60 Gy compared with controls, and no larvae were produced at 75 Gy. Irradiation of prereproductive adults of both sexes at 45 Gy under low oxygen (1-4%) caused a high level of sterility (>99%) while maintaining moderate survivorship for several weeks, and should suffice for sterile insect releases. Sterile insect technique holds potential for suppressing small hive beetle populations in newly invaded areas and limiting its spread. PMID:26470205

  2. Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Kim, Won Woo; Park, In Hwan; Kim, Hee Jong; Lee, Eun Jin; Jung, Jae Hoon [Research Center for Radiotherapy, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Cho, Lawrence Chin Soo; Song, Chang W. [Dept. of Radiation Oncology, University of Minnesota Medical School, Minneapolis (United States)

    2015-12-15

    Despite the increasing use of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) in recent years, the biological base of these high-dose hypo-fractionated radiotherapy modalities has been elusive. Given that most human tumors contain radioresistant hypoxic tumor cells, the radiobiological principles for the conventional multiple-fractionated radiotherapy cannot account for the high efficacy of SBRT and SRS. Recent emerging evidence strongly indicates that SBRT and SRS not only directly kill tumor cells, but also destroy the tumor vascular beds, thereby deteriorating intratumor microenvironment leading to indirect tumor cell death. Furthermore, indications are that the massive release of tumor antigens from the tumor cells directly and indirectly killed by SBRT and SRS stimulate anti-tumor immunity, thereby suppressing recurrence and metastatic tumor growth. The reoxygenation, repair, repopulation, and redistribution, which are important components in the response of tumors to conventional fractionated radiotherapy, play relatively little role in SBRT and SRS. The linear-quadratic model, which accounts for only direct cell death has been suggested to overestimate the cell death by high dose per fraction irradiation. However, the model may in some clinical cases incidentally do not overestimate total cell death because high-dose irradiation causes additional cell death through indirect mechanisms. For the improvement of the efficacy of SBRT and SRS, further investigation is warranted to gain detailed insights into the mechanisms underlying the SBRT and SRS.

  3. Environmental Research Division annual report: Center for Human Radiobiology, July 1983-June 1984. Part 2

    International Nuclear Information System (INIS)

    Epidemiological studies of the late effects of internal radium in man, and mechanistic investigations of those effects, have continued. The current status of the study is summarized. An experimental technique for preparing thin sections of bone and the application of that technique in studying the comparative distribution of radium and plutonium are described. Radiological dental changes due to radium in man and dog are compared. Survival of human fibroblasts irradiated with alpha particles in vitro was found to be higher when the average LET was higher. In the study of the late effects of thorium in man, the relative activities of the daughter products in the lung have been determined spectrometrically in vivo. The exhalation of thoron in these persons has been investigated in relation to lung burden of thorium and to personal factors such as smoking, age, and weight. The administration of two isotopes to large mammals has been used to demonstrate that the metabolism of plutonium is independent of route of entry and to determine the gastrointestinal absorption of plutonium. The effect of thermoluminescence on a scintillation radon counting system has been investigated quantitatively. Data on the exposure of 88 persons to radium were added to the data base, bringing the total to 2400 radium cases under study by the Center for Human Radiobiology. Separate abstracts were prepared for individual papers

  4. Neutron flux characterisation of the Pavia TRIGA Mark II research reactor for radiobiological and microdosimetric applications.

    Science.gov (United States)

    Alloni, D; Prata, M; Salvini, A; Ottolenghi, A

    2015-09-01

    Nowadays the Pavia TRIGA reactor is available for national and international collaboration in various research fields. The TRIGA Mark II nuclear research reactor of the Pavia University offers different in- and out-core neutron irradiation channels, each characterised by different neutron spectra. In the last two years a campaign of measurements and simulations has been performed in order to guarantee a better characterisation of these different fluxes and to meet the demands of irradiations that require precise information on these spectra in particular for radiobiological and microdosimetric studies. Experimental data on neutron fluxes have been collected analysing and measuring the gamma activity induced in thin target foils of different materials irradiated in different TRIGA experimental channels. The data on the induced gamma activities have been processed with the SAND II deconvolution code and finally compared with the spectra obtained with Monte Carlo simulations. The comparison between simulated and measured spectra showed a good agreement allowing a more precise characterisation of the neutron spectra and a validation of the adopted method. PMID:25958412

  5. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy

    International Nuclear Information System (INIS)

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence—expressed in terms of total cross sections—as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies. (paper)

  6. Radiobiology of Small Hive Beetle (Coleoptera: Nitidulidae) and Prospects for Management Using Sterile Insect Releases.

    Science.gov (United States)

    Downey, Danielle; Chun, Stacey; Follett, Peter

    2015-06-01

    Small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is considered a serious threat to beekeeping in the Western Hemisphere, Australia, and Europe mainly due to larval feeding on honey, pollen, and brood of the European honeybee, Apis mellifera L. Control methods are limited for this pest. Studies were conducted to provide information on the radiobiology of small hive beetle and determine the potential for sterile insect releases as a control strategy. Adult males and females were equally sensitive to a radiation dose of 80 Gy and died within 5-7 d after treatment. In reciprocal crossing studies, irradiation of females only lowered reproduction to a greater extent than irradiation of males only. For matings between unirradiated males and irradiated females, mean reproduction was reduced by >99% at 45 and 60 Gy compared with controls, and no larvae were produced at 75 Gy. Irradiation of prereproductive adults of both sexes at 45 Gy under low oxygen (1-4%) caused a high level of sterility (>99%) while maintaining moderate survivorship for several weeks, and should suffice for sterile insect releases. Sterile insect technique holds potential for suppressing small hive beetle populations in newly invaded areas and limiting its spread.

  7. Radiobiological investigation on the ray induced sterilization of east worm (Grapholita molesta busc., lepidoptera:tortricidae)

    International Nuclear Information System (INIS)

    Results of radiobiological investigations on the sterilizing effect of the ionizing radiation, used to treat pupae and imagines of the oriental fruit moth (G. molesta) are reported. The irradiation is realized with gamma rays (60Co) of 12-13 Gy/s (±5%). The parameters of the induced sterility are determined differently for male and female specimen. The sterilizing effect of gamma radiation on male specimen irradiated as pupae and adults results in lethal spermatozoa mutations. The functional interrelation (dose-dominant lethals) is described by curves of a mixed type, consisting of a linear and non-linear component. The established dynamics in the frequency of the mutations in the dose range suggests that the optimum sterilizing ray doses are in the range 400-500 Gy. Doses below 500 Gy (pupae) and 450 Gy (imago) do not reduce considerably the life of the male butterflies. The sterilizing effect on the female specimen after pupae and imagines irradiation is due to dominant lethal mutations in the oocytes. The interrelation (dose-dominant lethals) is described by curves of sigmoid configuration. The absolutely sterilizing dose for both ontogenic stages is 150 Gy. The irradiation of the female specimen causes partial sterility along with the induction of dominant lethals in the ovules

  8. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy.

    Science.gov (United States)

    Champion, C; Quinto, M A; Monti, J M; Galassi, M E; Weck, P F; Fojón, O A; Hanssen, J; Rivarola, R D

    2015-10-21

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies. PMID:26406277

  9. Radiobiology of Small Hive Beetle (Coleoptera: Nitidulidae) and Prospects for Management Using Sterile Insect

    International Nuclear Information System (INIS)

    Small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae), is considered a serious threat to beekeeping in the Western Hemisphere, Australia, and Europe mainly due to larval feeding on honey, pollen, and brood of the European honeybee, Apis mellifera L. Control methods are limited for this pest. Studies were conducted to provide information on the radiobiology of small hive beetle and determine the potential for sterile insect releases as a control strategy. Adult males and females were equally sensitive to a radiation dose of 80 Gy and died within 5–7 d after treatment. In reciprocal crossing studies, irradiation of females only lowered reproduction to a greater extent than irradiation of males only. For matings between unirradiated males and irradiated females, mean reproduction was reduced by >99% at 45 and 60 Gy compared with controls, and no larvae were produced at 75 Gy. Irradiation of prereproductive adults of both sexes at 45 Gy under low oxygen (1–4%) caused a high level of sterility (>99%) while maintaining moderate survivorship for several weeks, and should suffice for sterile insect releases. Sterile insect technique holds potential for suppressing small hive beetle populations in newly invaded areas and limiting its spread. (author)

  10. Radiobiology at ultra-high dose rates employing laser-driven ions

    Science.gov (United States)

    Hanton, F.; Doria, D.; Kakolee, K. F.; Kar, S.; Litt, S. K.; Fiorini, F.; Ahmed, H.; Green, S.; Jeynes, J. C. G.; Kavanagh, J.; Kirby, D.; Kirkby, K. J.; Lewis, C. L.; Merchant, M. J.; Nersisyan, G.; Prasad, R.; Prise, K.; Schettino, G.; Zpef, M.; Borghesi, M.

    2013-05-01

    The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 109 Gys-1 on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4+/-0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.

  11. Decontamination activities at the National Institute of Oncology and Radiobiology in Havana, Cuba

    International Nuclear Information System (INIS)

    The National Institute of Oncology and Radiobiology had a facility contaminated with 137Cs. The contamination was produced by a leaking source stored in the place. First decontamination work was performed in 1988. Some highly contaminated floor tiles and other contaminated items were removed. Spent sealed sources stored in the facility were collected. The facility was closed because of the remaining contamination. As the Regulatory Body allowed the unrestricted use of the facility, decontamination and decommissioning were needed. D and D activities were requested to the CPHR. Contamination surveys conducted in 1999 confirmed the extent of contamination with 137Cs. Items inside the contaminated area were carefully monitored and segregated. Six Radium sources were recovered. Physical and chemical methods of decontamination were used. For different reasons, the requirements established by the Regulatory Authority for decommissioning could not be achieved, and therefore the facility could not be released from regulatory control. A Radiological Status Report was done explaining the high cost of decontamination according to the established clearance levels. New alternatives were then proposed for decommissioning of this facility. (author)

  12. Light ion production for a future radiobiological facility at CERN: preliminary studies.

    Science.gov (United States)

    Stafford-Haworth, Joshua; Bellodi, Giulia; Küchler, Detlef; Lombardi, Alessandra; Röhrich, Jörg; Scrivens, Richard

    2014-02-01

    Recent medical applications of ions such as carbon and helium have proved extremely effective for the treatment of human patients. However, before now a comprehensive study of the effects of different light ions on organic targets has not been completed. There is a strong desire for a dedicated facility which can produce ions in the range of protons to neon in order to perform this study. This paper will present the proposal and preliminary investigations into the production of light ions, and the development of a radiobiological research facility at CERN. The aims of this project will be presented along with the modifications required to the existing linear accelerator (Linac3), and the foreseen facility, including the requirements for an ion source in terms of some of the specification parameters and the flexibility of operation for different ion types. Preliminary results from beam transport simulations will be presented, in addition to some planned tests required to produce some of the required light ions (lithium, boron) to be conducted in collaboration with the Helmholtz-Zentrum für Materialien und Energie, Berlin.

  13. Neutron flux characterisation of the Pavia Triga Mark II research reactor for radiobiological and microdosimetric applications

    International Nuclear Information System (INIS)

    Nowadays the Pavia TRIGA reactor is available for national and international collaboration in various research fields. The TRIGA Mark II nuclear research reactor of the Pavia University offers different in- and out-core neutron irradiation channels, each characterised by different neutron spectra. In the last two years a campaign of measurements and simulations has been performed in order to guarantee a better characterisation of these different fluxes and to meet the demands of irradiations that require precise information on these spectra in particular for radiobiological and microdosimetric studies. Experimental data on neutron fluxes have been collected analysing and measuring the gamma activity induced in thin target foils of different materials irradiated in different TRIGA experimental channels. The data on the induced gamma activities have been processed with the SAND II deconvolution code and finally compared with the spectra obtained with Monte Carlo simulations. The comparison between simulated and measured spectra showed a good agreement allowing a more precise characterisation of the neutron spectra and a validation of the adopted method. (authors)

  14. March to Armageddon: The United States and the nuclear arms race, 1939 to the present

    Energy Technology Data Exchange (ETDEWEB)

    Powaski, R.

    1987-01-01

    This history of the events, forces, and factors that have brought the world to the brink of nuclear holocaust probes two basic questions: what factors perpetuate the nuclear arms race and why is it so difficult to end. Starting with the opening days of World War II, this study traces the escalating arms race up to the present and notes that, while nuclear arsenals continue to grow, nuclear arms treaties are on the verge of collapse.

  15. INVESTIGATION OF STRESSES IN ARM TYPE ROTATING FLYWHEEL

    Directory of Open Access Journals (Sweden)

    S. M. Dhengle

    2012-02-01

    Full Text Available There are many causes of flywheel failure. Among them, maximum tensile and bending stresses induced in the rim and tensile stresses induced in the arm under the action of centrifugal forces are the main causes of flywheel failure. Hence in this work evaluation of stresses in the rim and arm are studied using finite element method and results are validated by analytical calculations .The models of flywheel having four, six and eight no. arms are developed for FE analysis. The FE analysis is carried out for different cases of loading applied on the flywheel and the maximum Von mises stresses and deflection in the rim are determined. From this analysis it is found that Maximum stresses induced are in the rim and arm junction. Due to tangential forces, maximum bending stresses occurs near the hub end of the arm. It is also observed that for low angular velocity the effect gravity on stresses and deflection of rim and arm is predominant.

  16. Forced displacement in Colombia: Magnitude and causes

    OpenAIRE

    Ana María Ibáñez

    2009-01-01

    The article describes the magnitude, geographical extent, and causes of forced populationdisplacements in Colombia. Forced migration in Colombia is a war strategy adopted by armed groups to strengthen territorial strongholds, weaken civilian support to the enemy, seize valuable lands, and produce and transport illegal drugs with ease. Forced displacement in Colombia today affects 3.5 million people. Equivalent to 7.8 percent of Colombia’s population, and second worldwide only to Sudan, this s...

  17. From Territorial Defence to Expeditionary Forces

    DEFF Research Database (Denmark)

    Nyemann, Dorthe; Staun, Jørgen Meedom

    2016-01-01

    After the Cold War the Danish Armed Forces moved away from its traditional role of territorial defense of Danish soil and towards a role as a globally deployable expeditionary force, imbedded with UK and/or US forces. This shift in national strategy amplified the requirements of the young officers......’ ability to think and act strategically in international missions. This article discusses to what extent this has been reflected in the education of the young officers....

  18. Optimized electrostatic inchworm motors using a flexible driving arm

    International Nuclear Information System (INIS)

    A new motor architecture that uses in-plane electrostatic gap-closing actuators along with a flexible driving arm mechanism to improve motor force density is introduced, optimized, manufactured, and tested. This motor operates similarly to other inchworm-based microactuators by accumulating small displacements from the actuators into much larger displacements in the motor. Using an analytical model of the inchworm motor based on the static force equilibrium condition, optimizations of a full motor design were performed to maximize motor force density. In addition, force losses from supporting flexures were included to calculate the theoretical motor efficiency for different motor designs. This force density optimization analysis of the gap-closing actuators and supporting motor structures provided the basis for designing and manufacturing inchworm motors with flexible driving arms and gap-closing actuators. The motor required only a single-mask fabrication and demonstrated robust performance, a maximum speed of 4.8 mm s−1, and a maximum force on the shuttle of 1.88 mN at 110 V which corresponds to area force density of 1.38 mN mm−2. In addition, instead of estimating motor force based on drawn or measured dimensions which often overestimates force, the demonstrated maximum motor force was measured using calibrated springs. The efficiency of the manufactured motor was measured at 8.75% using capacitance measurements and useful work output. (paper)

  19. DOE/CEC [Department of Energy/Commission of the European Communities] workshop on critical evaluation of radiobiological data to biophysical modeling

    International Nuclear Information System (INIS)

    The Department of Energy's Office of Health and Environmental Research and the Commission of the European Communities (CEC) Radiation Protection Program support the majority of Research in the Field of Radiobiological Modeling. This field of science develops models based on scientifically sound principles to predict biological response (at the cellular, molecular, and animal level) to exposure to low level ionizing radiation. Biophysical models are an important tool for estimating response of ionizing radiation at low doses and dose rates. Generally speaking, the biophysical models can be classified into two groups: (1) mechanistic models and (2) phenomenological models. Mechanistic models are based on some assumptions about the physical, chemical, or biological mechanisms of action in association with radiobiological data whereas the phenomenological models are based solely on available experimental data on radiobiological effects with less emphasis on mechanisms of action. There are a number of these models which are being developed. Since model builders rely on radiobiological data available in the literature either to develop mechanistic or phenomenological models, it is essential that a critical evaluation of existing radiobiological data be made and data that is generally considered good and most appropriate for biophysical modeling be identified. A Workshop jointly sponsored by the DOE and the CEC was held at Oak Ridge, Tennessee from June 23--25, 1988, to review the data available from physical and chemical, cellular and molecular and animal studies with ionizing radiation

  20. Wind power and defense interests on Gotland. Presentation of a joint project between the County Administrative Board, Region Gotland and the Swedish Armed Forces in 2011; Vindkraft och foersvarsintressen paa Gotland. Redovisning av ett samverkansprojekt mellan Laensstyrelsen, Region Gotland och Foersvarsmakten 2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The island of Gotland has a large potential for wind power production. An existing weather radar system, however, causes extensive restrictions for further development of wind power on Gotland. In a joint project during 2011 the County Administration Board of Gotland, the Municipality of Gotland and the Swedish Armed Forces have explored ways to overcome the existing conflicts. The project has been sponsored by the Swedish Energy Agency. Through the collaboration, the participants have gained a better understanding of various aspects of the conflicting interests. Studies have been carried out with the prospect to modelling alternative solutions to reduce the conflicts. The study regarding the radar system has been carried out by the Swedish Meteorological and Hydrological Inst.. This report present some practical solutions to avoid conflict in most of areas which are planned for wind power by the municipality. It is suggested that a complimentary radar can be built. A number of alternative localizations for the complimentary radar have been suggested and the potential effects for wind power production estimated. Costs for the suggested solutions have been calculated.

  1. ARM User Survey Report

    Energy Technology Data Exchange (ETDEWEB)

    Roeder, LR

    2010-06-22

    The objective of this survey was to obtain user feedback to, among other things, determine how to organize the exponentially growing data within the Atmospheric Radiation Measurement (ARM) Climate Research Facility, and identify users’ preferred data analysis system. The survey findings appear to have met this objective, having received approximately 300 responses that give insight into the type of work users perform, usage of the data, percentage of data analysis users might perform on an ARM-hosted computing resource, downloading volume level where users begin having reservations, opinion about usage if given more powerful computing resources (including ability to manipulate data), types of tools that would be most beneficial to them, preferred programming language and data analysis system, level of importance for certain types of capabilities, and finally, level of interest in participating in a code-sharing community.

  2. Robot arm apparatus

    Science.gov (United States)

    Nachbar, Henry D.

    1992-01-01

    A robot arm apparatus is provided for inspecting and/or maintaining an interior of a steam generator which has an outside wall and a port for accessing the interior of the steam generator. The robot arm apparatus includes a flexible movable conduit for conveying inspection and/or maintenance apparatus from outside the steam generator to the interior of the steam generator. The flexible conduit has a terminal working end which is translated into and around the interior of the steam generator. Three motors located outside the steam generator are employed for moving the terminal working end inside the steam generator in "x", "y", and "z" directions, respectively. Commonly conducted inspection and maintenance operations include visual inspection for damaged areas, water jet lancing for cleaning sludge deposits, core boring for obtaining sludge deposits, and scrubbing of internal parts.

  3. Radiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans

    International Nuclear Information System (INIS)

    The aim of this study is to evaluate the radiobiological impact of Acuros XB (AXB) vs. Anisotropic Analytic Algorithm (AAA) dose calculation algorithms in combined dose-volume and biological optimized IMRT plans of SBRT treatments for non-small-cell lung cancer (NSCLC) patients. Twenty eight patients with NSCLC previously treated SBRT were re-planned using Varian Eclipse (V11) with combined dose-volume and biological optimization IMRT sliding window technique. The total dose prescribed to the PTV was 60 Gy with 12 Gy per fraction. The plans were initially optimized using AAA algorithm, and then were recomputed using AXB using the same MUs and MLC files to compare with the dose distribution of the original plans and assess the radiobiological as well as dosimetric impact of the two different dose algorithms. The Poisson Linear-Quadatric (PLQ) and Lyman-Kutcher-Burman (LKB) models were used for estimating the tumor control probability (TCP) and normal tissue complication probability (NTCP), respectively. The influence of the model parameter uncertainties on the TCP differences and the NTCP differences between AAA and AXB plans were studied by applying different sets of published model parameters. Patients were grouped into peripheral and centrally-located tumors to evaluate the impact of tumor location. PTV dose was lower in the re-calculated AXB plans, as compared to AAA plans. The median differences of PTV(D95%) were 1.7 Gy (range: 0.3, 6.5 Gy) and 1.0 Gy (range: 0.6, 4.4 Gy) for peripheral tumors and centrally-located tumors, respectively. The median differences of PTV(mean) were 0.4 Gy (range: 0.0, 1.9 Gy) and 0.9 Gy (range: 0.0, 4.3 Gy) for peripheral tumors and centrally-located tumors, respectively. TCP was also found lower in AXB-recalculated plans compared with the AAA plans. The median (range) of the TCP differences for 30 month local control were 1.6 % (0.3 %, 5.8 %) for peripheral tumors and 1.3 % (0.5 %, 3.4 %) for centrally located tumors. The lower TCP

  4. 78 FR 78941 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2013-12-27

    ... Export Control Act, as amended (i) Prospective Purchaser: Pakistan (ii) Total Estimated Value: Major... Pakistan Peace Drive F-16 program. (iv) Military Department: Air Force (GAF) (v) Prior Related Cases, if...) of the Arms Export Control Act. ] POLICY JUSTIFICATION Pakistan--Technical Support Team (TST)...

  5. Armed Conflict: A Model for Understanding and Intervention

    Science.gov (United States)

    Death Studies, 2013

    2013-01-01

    Acts of deadly violence give rise to powerful emotions and trigger pre-programmed responses that often cause affected persons, including leaders, media, armed forces, and the general public, to act in ways that aggravate the situation and feed into cycles of violence. In this article, a model of the cycle of violence is presented that facilitates…

  6. Kiikuv maja / Anu Arm

    Index Scriptorium Estoniae

    Arm, Anu

    2006-01-01

    Eesti Kunstiakadeemia esimese kursuse arhitektuuriüliõpilaste II semestri töö. Juhendaja arhitekt Andres Alver, ehitamise Pedaspeale organiseeris suvepraktika juhendaja arhitekt Jaan Tiidemann. Autor Anu Arm, kaasa töötasid ja valmis ehitasid: Ott Alver, Maarja Elm, Mari Hunt, Alvin Järving, Marten Kaevats, Riho Kerge, Reedik Poopuu, Anu Põime, Helen Rebane, Kaisa Saarva, Martin Tago, Reet Volt. Valmis: 19. VIII 2006

  7. In vitro and in vivo ion beam targeted micro-irradiation for radiobiology

    International Nuclear Information System (INIS)

    The main goal of radiobiology is to understand the effects of ionizing radiations on the living. These past decades, ion microbeams have shown to be important tools to study for example the effects of low dose exposure, or the bystander effect. Since 2003, the CENBG has been equipped with a system to perform targeted micro-irradiation of living samples. Recently, microbeams applications on this subject have diversified and the study of DNA repair mechanisms at the cellular and multicellular scales, in vitro and in vivo, has become possible thanks to important evolutions of fluorescence imaging techniques and cellular biology. To take into account these new approaches, the CENBG micro-irradiation beamline has been entirely redesigned and rebuilt to implement new features and to improve the existing ones. My PhD objectives were i) commissioning the facility, ii) characterizing the system on track etch detectors, and on living samples, iii) implementing protocols to perform targeted irradiations of living samples with a con-trolled delivered dose, at the cellular and multicellular scales, and to visualize the early consequences online, iv) modelling these irradiations to explain the biological results using the calculated physical data. The work of these past years has allowed us i) to measure the performances of our system: a beam spot size of about 2 μm and a targeting accuracy of ± 2 μm, and to develop ion detection systems for an absolute delivered dose control, ii) to create highly localized radiation-induced DNA damages and to see online the recruitment of DNA repair proteins, iii) to apply these protocols to generate radiation-induced DNA damages in vivo inside a multicellular organism at the embryonic stage: Caenorhabditis elegans. These results have opened up many perspectives on the study of the interaction between ionizing radiations and the living, at the cellular and multicellular scales, in vitro and in vivo. (author)

  8. Radiobiological investigations at tumor cell lines by exploiting aspects of chronological dose administration

    Directory of Open Access Journals (Sweden)

    Waldemar Ulmer

    2014-08-01

    Full Text Available Purpose: Using 31P-NMR spectroscopy the chronological behavior of the ATP-metabolism of the tumor spheroids C3H-MA, 9L-Gliome and the mono-layer L1210 has been analyzed via increase and decrease of the β-peak. The goal of this study is to elaborate an optimal fractionation scheme with regard to the irradiation of tumor spheroids and possibly to human tumors.  Methods: The NMR-spectroscopy has been carried out by the FID technique (free induction decay, and the intensity of the β-peak provides a measure of the survival fraction S after radiation exposure with 30 kV X-rays. The linear-quadratic model has to be generalized in order to be valid for irradiation beyond the shoulder. Results and Conclusion: All three cell lines show characteristic periods, and a homeostatic control cannot be recognized. Essential components of these periods are circadian (i.e. one day, circa-semiseptan (i.e. 3.5 days and circa-septan (i.e. one week. The determination of the survival fractions provides an optimum exploitation of radiation damages, when the ATP-concentration assumes a maximum value. This optimum is reached, when all three cycles exhibit an ATP maximum, which is only possible by accounting for the circa-septan rhythm.--------------------------------------Cite this article as: Ulmer W. Radiobiological investigations at tumor cell lines by exploiting aspects of chronological dose administration. Int J Cancer Ther Oncol 2014; 2(3:020312. DOI:10.14319/ijcto.0203.12 

  9. Functional and histological assessment of the radiobiology of normal rat lung in BNCT

    International Nuclear Information System (INIS)

    This study investigated the radiobiology and sensitivity of the normal rat lung to Boron Neutron Capture Therapy (BNCT) radiation. Rat thorax irradiations were carried out with x-rays or with neutrons in the presence or absence of p-boronophenylalanine (BPA). Lung damage were assessed functionally with breathing rate measurement up to 180 days after irradiation and then histologically. Breathing rates 20% (∼3 σ) above the control group (sham-irradiated rats) mean were considered as positive responses to lung radiation damage. Though most responding animals demonstrated radiation induced pneumonitis (≤110 days) as well as pulmonary fibrosis (>110 days), some animals receiving neutrons plus BPA showed only the latter. The breathing rate dose response data were fit using probit analysis. The ED50 values measured for x-rays, neutron beam only, and neutrons plus BPA were 11.5±0.4 Gy, 9.2±0.5 Gy, and 6.7±0.4 Gy, respectively. The biological weighting factors for the neutron beam (n+γ), the thermal neutron dose component, and the 10B dose component were determined to be 1.2±0.1, 2.2±0.4, and 2.3±0.3, respectively. The histological dose response curves were linear. Consistent with the functional assay, the weighting factors measured histologically were 1.2±0.1 for the thermal neutron beam and 1.9±0.2 for the 10B dose component. (author)

  10. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    Energy Technology Data Exchange (ETDEWEB)

    Beyreuther, Elke

    2010-09-10

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount

  11. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    International Nuclear Information System (INIS)

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount

  12. High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor beta type II receptor in a panel of small cell lung cancer cell lines

    DEFF Research Database (Denmark)

    Hougaard, S; Krarup, M; Nørgaard, P;

    1998-01-01

    Our panel of SCLC cell lines have previously been examined for their radiobiological characteristics and sensitivity to treatment with TGF beta 1. In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type II receptor (TGF beta-r...... role for the repair of radiation induced DNA damage in SCLC....

  13. Automation of the particle dosimetry and the dose application for radiobiological experiments at a vertical proton beam

    CERN Document Server

    Moertel, H; Eyrich, W; Fritsch, M; Distel, L

    2002-01-01

    A facility with a vertical beam for radiobiological experiments with low-energy protons has been setup at the Tandem accelerator at Erlangen. This energy region is optimal to investigate the biological effects of the linear energy transfer in the Bragg region under physiological conditions. A new automated data acquisition system for dosimetry and monitoring based on a personal computer was developed and optimized for this setup. A specially designed sample holder offers possibilities of cooling or changing of atmosphere during irradiation. First irradiations of biological samples have shown the functionality of the setup.

  14. Neural Network L-two-gain Robust Control for Flexible Arm Space Robot Based on Virtual Control Force Conception%柔性臂空间机器人基于虚拟力概念的神经网络L2增益鲁棒控制

    Institute of Scientific and Technical Information of China (English)

    梁捷; 陈力

    2012-01-01

    探讨本体位置不控、姿态受控的漂浮基柔性臂空间机器人系统在惯性参数不确定情况下的动力学建模与控制问题.根据系统位置几何关系、动量守恒关系和第二类拉格朗日方程,由假设模态法,建立漂浮基柔性臂空间机器人的系统动力学模型.利用该模型,针对系统惯性参数不确定情况,提出具有L2扰动抑制的刚性运动神经网络L2增益鲁棒控制策略,以使柔性臂空间机器人的本体姿态到达期望位置的同时,机械臂各关节铰能够协调地跟踪关节空间的期望轨迹.为了主动抑制柔性振动,运用虚拟力的概念,构造同时反映柔性模态和刚性运动轨迹的混合期望轨迹,通过改造原有的控制方案,提出基于虚拟力概念的神经网络L2增益鲁棒控制策略.提出控制器的优点在于,既不要求系统动力学方程关于惯性参数呈线性函数关系,也无须预知系统精确的动力学模型;由于运用了虚拟力的概念,从而仅通过设计一个控制输入便可同时保证刚性轨迹跟踪并对柔性振动进行主动抑制,更适应于空间机器人系统的实际应用.理论分析及仿真算例均表明了控制方法的可行性.%Concerned dynamic modeling and control problems are discussed for free-floating flexible arm space robot with uncertain parameters and an uncontrolled base. According to the geometric relationship and law of conversation of momentum, the Lagrange equation of the second kind is utilized to model the dynamic function of the flexible arm space robot incorporating the assumed modes method. By using this model, a neural network L-two-gain robust control scheme with i-two-gain disturbance attenuation is proposed to dominate the base attitude and the joint angle of manipulator to track desired trajectories synchronously in joint space on condition that system parameters are unknown. In order to damp out vibration, conception of virtual force is used to design

  15. Labor Force

    Science.gov (United States)

    Occupational Outlook Quarterly, 2012

    2012-01-01

    The labor force is the number of people ages 16 or older who are either working or looking for work. It does not include active-duty military personnel or the institutionalized population, such as prison inmates. Determining the size of the labor force is a way of determining how big the economy can get. The size of the labor force depends on two…

  16. Elastic lever arm model for myosin V

    CERN Document Server

    Vilfan, A

    2005-01-01

    We present a mechanochemical model for myosin V, a two-headed processive motor protein. We derive the properties of a dimer from those of an individual head, which we model both with a 4-state cycle (detached, attached with ADP.Pi, attached with ADP and attached without nucleotide) and alternatively with a 5-state cycle (where the power stroke is not tightly coupled to the phosphate release). In each state the lever arm leaves the head at a different, but fixed, angle. The lever arm itself is described as an elastic rod. The chemical cycles of both heads are coordinated exclusively by the mechanical connection between the two lever arms. The model explains head coordination by showing that the lead head only binds to actin after the power stroke in the trail head and that it only undergoes its power stroke after the trail head unbinds from actin. Both models (4- and 5-state) reproduce the observed hand-over-hand motion and fit the measured force-velocity relations. The main difference between the two models c...

  17. Development of Integrated ASR Model Forcing Data and Their Applications to Improve CAM

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Minghua [Research Foundation of the State University of New York, Albany, NY (United States)

    2016-01-01

    In this project, we have (1) improved the constrained variational analysis algorithm of ARM model forcing data, and (2) used the ARM forcing data to identify systematic biases in clouds and radiation in the CAM5 and design new physical parameterizations to improve it.

  18. Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?

    Directory of Open Access Journals (Sweden)

    Hong Song

    2012-06-01

    Full Text Available Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from accelerated heavy ion beam studies. In heavy ion beam therapy of loco-regional tumors, the modulation of steep transition to very high LET peak as the particle approaches the end of its track (known as the Bragg peak enables greater delivery of biologically potent radiation to the deep seated tumors while sparing normal tissues surrounding the tumor with the relatively low LET track segment part of the heavy ion beam. Moreover, fractionation of the heavy ion beam can further enhance the peak-to-plateau relative biological effectiveness (RBE ratio. In contrast, internally delivered alpha particle radiopharmaceutical therapy lack the control of Bragg peak energy deposition and the dose rate is determined by the administered activity, alpha-emitter half-life and biological kinetics of the radiopharmaceutical. The therapeutic ratio of tumor to normal tissue is mainly achieved by tumor specific targeting of the carrier antibody. In this brief overview, we review the radiobiology of high LET radiations learned from ion beam studies and identify the features that are also applicable for the development of alpha-emitter labeled antibodies. The molecular mechanisms underlying DNA double strand break repair response to high LET radiation are also discussed.

  19. Studies of UV-cured CR-39 recording properties in view of its applicability in radiobiological experiments with alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Gaillard, Sylvain [Laboratoire de Microanalyses Nucleaires, UMR CEA E4, UFR Sciences et Techniques, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon cedex (France); Ross, Caroline J. [Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD (United Kingdom); Armbruster, Vincent [Laboratoire d' Optique P.M. DUFFIEUX, UFR Sciences et Techniques, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon cedex (France); Hill, Mark A. [Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD (United Kingdom); Stevens, David L. [Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD (United Kingdom); Gharbi, Tijani [Laboratoire d' Optique P.M. DUFFIEUX, UFR Sciences et Techniques, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon cedex (France); Fromm, Michel [Laboratoire de Microanalyses Nucleaires, UMR CEA E4, UFR Sciences et Techniques, Universite de Franche-Comte, 16 route de Gray, 25030 Besancon cedex (France)

    2005-11-15

    In radiobiology, low doses of high-LET radiation correspond to a few particle traversals through the cell population. Therefore, for studies on cell monolayers irradiated with a low dose of {alpha}-particles, it is extremely useful if the number and position of particle traversals can be determined. In this study we describe a new method, based on UV-curing, to obtain a 10{mu}m thick CR-39 grafted onto a 2.5{mu}m thick PolyEthylene Terephtalate (PET). This thin double polymeric layer, used as a dish base, has a regular and reproducible detector thickness which can be traversed by 3.5MeV {alpha}-particles, with a sufficient residual energy to traverse mammalian cells attached to the base. The recording properties of a PET-CR-39 dish, together with a demonstration of its use for radiobiological experiments, are presented. This new tool allows the precise determination of single-track impact parameters at a sub-cellular level.

  20. Study on a 7-DOF anthropomorphic weld arm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A kind of new obstacle space expression is proposed in this paper, in which a virtual force field (VFF) is built. Using the torque and joint optimization acted by the virtual force field on the anthropomorphic weld arm, the real-time selection of a redundant join (R-joint) is done and its equivalent virtual torque is obtained, thus the redundant joint can be controlled with whose force feedback. An inverse kinematics solution of a 6-DOF robot is applied to other six joints of the arm. Simulation experiments indicate the new inverse kinematics solution has perfect collision avoidance effect, and it is well simplified. Therefore, it can be applied to a welding task in complex operation space.

  1. Emerging issues in radiobiology and cancer research - the impact of non-targeted effects

    International Nuclear Information System (INIS)

    Since the acceptance that non-targeted effects (NTE) can be measured in unirradiated cells or distant progeny of irradiated cells, the discussion has developed about the relevance of these effects for radiobiology and radiation protection since they increase the complexity of the radiation response and allow for outcomes which are not as predictable as they were under the 'old rules'. Specific examples will be presented and analysed which challenge accepted paradigms. 1. Data show that bystander mechanisms are either on or off in cells and that the 'on' threshold appears to be at a very low dose (mGy range). 2. Data suggest that adaptive responses are induced not only in neighbouring cells but in organisms which receive bystander signals. 3. Data show that chronic exposures to alpha or gamma irradiation lead to complex responses in organisms which can be adaptive and protective. 4. Evidence suggests that mixed contaminant exposures which include radiation can have sub-additive or synergistic effects. A key consequence of findings in NTE biology is that at any given level of organization, from gene to ecosystem - communication of stress signals and heritability of stress adaptations provide the bridges linking one hierarchical level to the next and enable the rapid propagation of change triggered by stress at one level, resulting in change at a higher (or lower?) level. Evolution could thus be regulated through communicated signals between cells, individuals, and populations which control and optimize responses coordinating the emergence of exquisitely tuned systems which can adapt rapidly to micro or macro environmental change. A current view of cancer is that it is a 'systems level' disease which can not be understood or treated by looking at individual genes or pathways in the traditional way. Rather, a system approach is required with looks at the environment at both cellular and organismal levels to understand what has been perturbed. We suggest that bystander

  2. Modeling detector response in solid-state systems for radiation therapy and radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Hugtenburg, R.P. [School of Physics and Astronomy, University of Birmingham, B15 2TT, UK (United Kingdom); Bradley, D.A. [Department of Physics, University of Surrey, Guildford, GU2 7XH, UK (United Kingdom)

    2006-07-01

    -filled proportional counters (TEPC) where it is anticipated that intercomparisons with experiment will help to validate the use of such codes for the microdosimetry predictions on the sub-cellular scale in radiobiological systems. Monte Carlo based microdosimetry calculations are also expected to assist in explaining LET dependencies found in many solid-state detector systems. (Author)

  3. Radiobiological evaluation of forward and inverse IMRT using different fractionations for head and neck tumours

    Directory of Open Access Journals (Sweden)

    Capela Miguel

    2010-06-01

    Full Text Available Abstract Purpose To quantify the radiobiological advantages obtained by an Improved Forward Planning technique (IFP and two IMRT techniques using different fractionation schemes for the irradiation of head and neck tumours. The conventional radiation therapy technique (CONVT was used here as a benchmark. Methods Seven patients with head and neck tumours were selected for this retrospective planning study. The PTV1 included the primary tumour, PTV2 the high risk lymph nodes and PTV3 the low risk lymph nodes. Except for the conventional technique where a maximum dose of 64.8 Gy was prescribed to the PTV1, 70.2 Gy, 59.4 Gy and 50.4 Gy were prescribed respectively to PTV1, PTV2 and PTV3. Except for IMRT2, all techniques were delivered by three sequential phases. The IFP technique used five to seven directions with a total of 15 to 21 beams. The IMRT techniques used five to nine directions and around 80 segments. The first, IMRT1, was prescribed with the conventional fractionation scheme of 1.8 Gy per fraction delivered in 39 fractions by three treatment phases. The second, IMRT2, simultaneously irradiated the PTV2 and PTV3 with 59.4 Gy and 50.4 Gy in 28 fractions, respectively, while the PTV1 was boosted with six subsequent fractions of 1.8 Gy. Tissue response was calculated using the relative seriality model and the Poisson Linear-Quadratic-Time model to simulate repopulation in the primary tumour. Results The average probability of total tumour control increased from 38% with CONVT to 80% with IFP, to 85% with IMRT1 and 89% with IMRT2. The shorter treatment time and larger dose per fraction obtained with IMRT2 resulted in an 11% increase in the probability of control in the PTV1 with respect to IFP and 7% relatively to IMRT1 (p Conclusions A significant improvement in treatment outcome was obtained with IMRT compared to conventional radiation therapy. The practical and biological advantages of IMRT2, employing a shorter treatment time, may

  4. Comparison of the radiobiological effects of Boron neutron capture therapy (BNCT) and conventional Gamma Radiation

    International Nuclear Information System (INIS)

    BNCT is an experimental radiotherapeutic modality that uses the capacity of the isotope 10B to capture thermal neutrons leading to the production of 4He and 7Li, particles with high linear energy transfer (LET). The aim was to evaluate and compare in vitro the mechanisms of response to the radiation arising of BNCT and conventional gamma therapy. We measured the survival cell fraction as a function of the total physical dose and analyzed the expression of p27/Kip1 and p53 by Western blotting in cells of colon cancer (ARO81-1). Exponentially growing cells were distributed into the following groups: 1) BPA (10 ppm 10B) + neutrons; 2) BOPP (10 ppm 10B) + neutrons; 3) neutrons alone; 4) gamma-rays. A control group without irradiation for each treatment was added. The cells were irradiated in the thermal neutron beam of the RA-3 (flux= 7.5 109 n/cm2 sec) or with 60Co (1Gy/min) during different times in order to obtain total physical dose between 1-5 Gy (±10 %). A decrease in the survival fraction as a function of the physical dose was observed for all the treatments. We also observed that neutrons and neutrons + BOPP did not differ significantly and that BPA was the more effective compound. Protein extracts of irradiated cells (3Gy) were isolated to 24 h and 48 h post radiation exposure. The irradiation with neutrons in presence of 10BPA or 10BOPP produced an increase of p53 at 24 h maintain until 48 h. On the contrary, in the groups irradiated with neutrons alone or gamma the peak was observed at 48 hr. The level of expression of p27/Kip1 showed a reduction of this protein in all the groups irradiated with neutrons (neutrons alone or neutrons plus boron compound), being more marked at 24 h. These preliminary results suggest different radiobiological response for high and low let radiation. Future studies will permit establish the role of cell cycle in the tumor radio sensibility to BNCT. (author)

  5. Three-dimensional radiobiological dosimetry of kidneys for treatment planning in peptide receptor radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, Sebastien; Hobbs, Robert F.; Boubaker, Ariane; Buchegger, Franz; He Bin; Frey, Eric C.; Sgouros, George [Institute of Radiation Physics, Lausanne University Hospital, 1007 Lausanne (Switzerland); Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231 (United States); Department of Nuclear Medicine, Lausanne University Hospital, 1011 Lausanne (Switzerland); Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231 (United States)

    2012-10-15

    Purpose: Peptide receptor radionuclide therapy (PRRT) delivers high absorbed doses to kidneys and may lead to permanent nephropathy. Reliable dosimetry of kidneys is thus critical for safe and effective PRRT. The aim of this work was to assess the feasibility of planning PRRT based on 3D radiobiological dosimetry (3D-RD) in order to optimize both the amount of activity to administer and the fractionation scheme, while limiting the absorbed dose and the biological effective dose (BED) to the renal cortex. Methods: Planar and SPECT data were available for a patient examined with {sup 111}In-DTPA-octreotide at 0.5 (planar only), 4, 24, and 48 h post-injection. Absorbed dose and BED distributions were calculated for common therapeutic radionuclides, i.e., {sup 111}In, {sup 90}Y and {sup 177}Lu, using the 3D-RD methodology. Dose-volume histograms were computed and mean absorbed doses to kidneys, renal cortices, and medullae were compared with results obtained using the MIRD schema (S-values) with the multiregion kidney dosimetry model. Two different treatment planning approaches based on (1) the fixed absorbed dose to the cortex and (2) the fixed BED to the cortex were then considered to optimize the activity to administer by varying the number of fractions. Results: Mean absorbed doses calculated with 3D-RD were in good agreement with those obtained with S-value-based SPECT dosimetry for {sup 90}Y and {sup 177}Lu. Nevertheless, for {sup 111}In, differences of 14% and 22% were found for the whole kidneys and the cortex, respectively. Moreover, the authors found that planar-based dosimetry systematically underestimates the absorbed dose in comparison with SPECT-based methods, up to 32%. Regarding the 3D-RD-based treatment planning using a fixed BED constraint to the renal cortex, the optimal number of fractions was found to be 3 or 4, depending on the radionuclide administered and the value of the fixed BED. Cumulative activities obtained using the proposed simulated

  6. Impact Effect Analysis of Dual-arm Space Robot Capturing a Non-cooperative Target and Force/Position Robust Stabilization Control for Closed-chain Hybrid System%双臂空间机器人捕获非合作目标冲击效应分析及闭链混合系统力/位形鲁棒镇定控制

    Institute of Scientific and Technical Information of China (English)

    董楸煌; 陈力

    2015-01-01

    分析漂浮基双臂空间机器人捕获非合作目标所受的冲击影响效应,及捕获后空间机器人和目标组成的闭链混合系统对目标夹持内力和位形的鲁棒镇定控制。将捕获目标过程视为两机械臂末端与目标碰撞前、碰撞过程和碰撞后三个阶段。在碰撞前空间机器人和目标是分离的两分体系统,利用第二类拉格朗日方程建立漂浮基双臂空间机器人系统的动力学模型。在机械臂末端与目标碰撞阶段,基于空间机器人与目标总动量守恒,利用动量定理计算翻滚目标对空间机器人运动状态的冲击影响效应。在碰撞后,双臂空间机器人已捕获翻滚目标并组成闭链混合系统,针对混合系统在碰撞阶段受冲击影响而产生不稳定运动,提出一种鲁棒控制算法对其进行镇定控制,以实现双臂对目标夹持内力和空间机器人位形的协调控制,并达到期望的稳定状态。数值仿真验证了上述控制算法的有效性。%The impact effect of a free-floating dual-arm space robot to capture a non-cooperative target is analyzed, and during the post-capture the space robot and the target compose a closed-chaln hybrid system, then a clamp force and position robust stabilization control is discussed. The target capture process is considered as pre-impact phase,impact phase and post-impact phase. The space robot and target are separated subsystem in the pre-impact phase, and the dynamics model of free-floating space robot is derived by the second Lagrange equation. In the impact phase, base on the total momentum conservation of space robot and target, the impact effect for the space robot motion is calculated by momentum theorem. In the post-impact phase, the dual-arm space robot has captured the target and formed a closed-chaln hybrid system, considering the unstable motion which is caused by the impact effect in the impact phase, a robust control algorithm is proposed

  7. Radiobiologic comparison of helical tomotherapy, intensity modulated radiotherapy, and conformal radiotherapy in treating lung cancer accounting for secondary malignancy risks

    International Nuclear Information System (INIS)

    The aim of the present study is to examine the importance of using measures to predict the risk of inducing secondary malignancies in association with the clinical effectiveness of treatment plans in terms of tumor control and normal tissue complication probabilities. This is achieved by using radiobiologic parameters and measures, which may provide a closer association between clinical outcome and treatment delivery. Overall, 4 patients having been treated for lung cancer were examined. For each of them, 3 treatment plans were developed based on the helical tomotherapy (HT), multileaf collimator-based intensity modulated radiation therapy (IMRT), and 3-dimensional conformal radiation therapy (CRT) modalities. The different plans were evaluated using the complication-free tumor control probability (p+), the overall probability of injury (pI), the overall probability of control/benefit (pB), and the biologically effective uniform dose (D¯¯). These radiobiologic measures were used to develop dose-response curves (p-D¯¯ diagram), which can help to evaluate different treatment plans when used in conjunction with standard dosimetric criteria. The risks for secondary malignancies in the heart and the contralateral lung were calculated for the 3 radiation modalities based on the corresponding dose-volume histograms (DVHs) of each patient. Regarding the overall evaluation of the different radiation modalities based on the p+ index, the average values of the HT, IMRT, and CRT are 67.3%, 61.2%, and 68.2%, respectively. The corresponding average values of pB are 75.6%, 70.5%, and 71.0%, respectively, whereas the average values of pI are 8.3%, 9.3%, and 2.8%, respectively. Among the organs at risk (OARs), lungs show the highest probabilities for complications, which are 7.1%, 8.0%, and 1.3% for the HT, IMRT, and CRT modalities, respectively. Similarly, the biologically effective prescription doses (DB¯¯) for the HT, IMRT, and CRT modalities are 64.0, 60.9, and 60.8 Gy

  8. Radiobiologic comparison of helical tomotherapy, intensity modulated radiotherapy, and conformal radiotherapy in treating lung cancer accounting for secondary malignancy risks

    Energy Technology Data Exchange (ETDEWEB)

    Komisopoulos, Georgios [Department of Medical Physics, Medical School, University of Patras, Patras (Greece); Mavroidis, Panayiotis, E-mail: mavroidis@uthscsa.edu [Department of Radiation Oncology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX (United States); Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Stockholm (Sweden); Rodriguez, Salvador; Stathakis, Sotirios; Papanikolaou, Nikos [Department of Radiation Oncology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX (United States); Nikiforidis, Georgios C.; Sakellaropoulos, Georgios C. [Department of Medical Physics, Medical School, University of Patras, Patras (Greece)

    2014-01-01

    The aim of the present study is to examine the importance of using measures to predict the risk of inducing secondary malignancies in association with the clinical effectiveness of treatment plans in terms of tumor control and normal tissue complication probabilities. This is achieved by using radiobiologic parameters and measures, which may provide a closer association between clinical outcome and treatment delivery. Overall, 4 patients having been treated for lung cancer were examined. For each of them, 3 treatment plans were developed based on the helical tomotherapy (HT), multileaf collimator-based intensity modulated radiation therapy (IMRT), and 3-dimensional conformal radiation therapy (CRT) modalities. The different plans were evaluated using the complication-free tumor control probability (p{sub +}), the overall probability of injury (p{sub I}), the overall probability of control/benefit (p{sub B}), and the biologically effective uniform dose (D{sup ¯¯}). These radiobiologic measures were used to develop dose-response curves (p-D{sup ¯¯} diagram), which can help to evaluate different treatment plans when used in conjunction with standard dosimetric criteria. The risks for secondary malignancies in the heart and the contralateral lung were calculated for the 3 radiation modalities based on the corresponding dose-volume histograms (DVHs) of each patient. Regarding the overall evaluation of the different radiation modalities based on the p{sub +} index, the average values of the HT, IMRT, and CRT are 67.3%, 61.2%, and 68.2%, respectively. The corresponding average values of p{sub B} are 75.6%, 70.5%, and 71.0%, respectively, whereas the average values of p{sub I} are 8.3%, 9.3%, and 2.8%, respectively. Among the organs at risk (OARs), lungs show the highest probabilities for complications, which are 7.1%, 8.0%, and 1.3% for the HT, IMRT, and CRT modalities, respectively. Similarly, the biologically effective prescription doses (D{sub B}{sup ¯¯}) for the

  9. Force sensing

    OpenAIRE

    Sanders, David

    2007-01-01

    A young child can explore and learn and compensate for unknown dynamics by prodding, pushing, touching, grasping and feeling. Force sensing and software research could soon allow artificial mechanisms to do the same. Force sensing has its roots in strain gauges, piezoelectrics, Wheatstone bridges, automation, robotics, grippers and virtual reality. That force sensing research has now become commonplace and has expanded from those roots to include so much more: video games, athletic equipment,...

  10. The Influences of Arm Resist Motion on a CAR Crash Test Using Hybrid III Dummy with Human-Like Arm

    Science.gov (United States)

    Kim, Yongchul; Youm, Youngil; Bae, Hanil; Choi, Hyeonki

    Safety of the occupant during the crash is very essential design element. Many researches have been investigated in reducing the fatal injury of occupant. They are focusing on the development of a dummy in order to obtain the real human-like motion. However, they have not considered the arm resist motion during the car accident. In this study, we would like to suggest the importance of the reactive force of the arm in a car crash. The influences of reactive force acting on the human upper extremity were investigated using the impedance experimental method with lumped mass model of hand system and a Hybrid III dummy with human-like arm. Impedance parameters (e.g. inertia, spring constant and damping coefficient) of the elbow joint in maximum activation level were measured by free oscillation test using single axis robot. The results showed that without seat belt, the reactive force of human arm reduced the head, chest, and femur injury, and the flexion moment of the neck is higher than that of the conventional dummy.

  11. Clinical radiobiology of glioblastoma multiforme. Estimation of tumor control probability from various radiotherapy fractionation schemes

    Energy Technology Data Exchange (ETDEWEB)

    Pedicini, Piernicola [I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, Rionero-in-Vulture (Italy); Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Unit of Radiotherapy, Rionero-in-Vulture (Italy); Fiorentino, Alba [Sacro Cuore - Don Calabria Hospital, Radiation Oncology Department, Negrar, Verona (Italy); Simeon, Vittorio [I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Laboratory of Preclinical and Translational Research, Rionero-in-Vulture (Italy); Tini, Paolo; Pirtoli, Luigi [University of Siena and Tuscany Tumor Institute, Unit of Radiation Oncology, Department of Medicine Surgery and Neurological Sciences, Siena (Italy); Chiumento, Costanza [Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Unit of Radiotherapy, Rionero-in-Vulture (Italy); Salvatore, Marco [I.R.C.C.S. SDN Foundation, Unit of Nuclear Medicine, Napoli (Italy); Storto, Giovanni [I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, Rionero-in-Vulture (Italy)

    2014-10-15

    The aim of this study was to estimate a radiobiological set of parameters from the available clinical data on glioblastoma (GB). A number of clinical trial outcomes from patients affected by GB and treated with surgery and adjuvant radiochemotherapy were analyzed to estimate a set of radiobiological parameters for a tumor control probability (TCP) model. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (α), repair capability (b), and repopulation doubling time (T{sub d}) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (T{sub k}). The results were used to formulate a hypothesis for a scheduleexpected to significantly improve local control. The 95 % confidence intervals (CI{sub 95} {sub %}) of all parameters are also discussed. The pooled analysis employed to estimate the parameters summarizes the data of 559 patients, while the studies selected to verify the results summarize data of 104 patients. The best estimates and the CI{sub 95} {sub %} are α = 0.12 Gy{sup -1} (0.10-0.14), b = 0.015 Gy{sup -2} (0.013-0.020), α/b = 8 Gy (5.0-10.8), T{sub d} = 15.4 days (13.2-19.5), N = 1 . 10{sup 4} (1.2 . 10{sup 3} - 1 . 10{sup 5}), and T{sub k} = 37 days (29-46). The dose required to offset the repopulation occurring after 1 day (D{sub prolif}) and starting after T{sub k} was estimated as 0.30 Gy/day (0.22-0.39). The analysis confirms a high value for the α/b ratio. Moreover, a high intrinsic radiosensitivity together with a long kick-off time for accelerated repopulation and moderate repopulation kinetics were found. The results indicate a substantial independence of the duration of the overall treatment and an improvement in the treatment effectiveness by increasing the total dose without increasing the dose fraction. (orig.) [German] Schaetzung eines strahlenbiologischen Parametersatzes auf der Grundlage klinischer Daten bei

  12. Internationally recognised armed forces / Urmas Roosimägi

    Index Scriptorium Estoniae

    Roosimägi, Urmas

    1999-01-01

    Eesti Kaitseväe juhataja kohusetäitja kolonel Urmas Roosimägi Eesti kaitseväest, osalemisest NATO-PFP (NATO-Partnership for Peace) programmis ja sõjalisest koostööst NATO partnerriikidega. Urmas Roosimägi biograafia. Programm Partnerlus Rahu Nimel

  13. Mobilization and Defence plans of the Latvian Armed forces

    Index Scriptorium Estoniae

    Kuzmins, Valdis

    2013-01-01

    Esimesel iseseisvusperioodil töötati välja kolm kaitseplaani, igaühega neist kaasnes mobilisatsiooniplaan. Rahvusvahelise olukorra muutudes töötati ka välja neljas mobilisatsiooniplaan ja alustati viienda mobilisatsiooniplaani väljatöötamist, mida ei jõutud aga lõpetada

  14. Update: malaria, U.S. Armed Forces, 2011.

    Science.gov (United States)

    2012-01-01

    U.S. service members are at risk of malaria when they are assigned to endemic areas (e.g., Korea), participate in operations in endemic areas (e.g., Afghanistan, Africa) and visit malarious areas during personal travel. In 2011, 124 service members were reported with malaria. Nearly three-fourths of cases were presumably acquired in Afghanistan (n=91) and one-fifth were considered acquired in Africa (n=24). One-quarter of cases were caused by P. vivax and one-fifth by P. falciparum (including 6 Afghanistan-acquired infections); most cases were reported as "unspecified" malaria. Malaria was diagnosed/reported from 51 different medical facilities in the United States, Afghanistan, Kyrgyzstan, Iraq, Germany and Korea. Providers of care to military members should be knowledgeable regarding and vigilant for clinical presentations of malaria outside of endemic areas. PMID:22309389

  15. A Medicosocial Study Of Paraplegics In Armed Forces

    Directory of Open Access Journals (Sweden)

    Dutta Col P.K

    1986-01-01

    Full Text Available A cross sectional study of 81 paraplegics was carried out to determine various medical and psychosocial aspects of the disability. Majority of the cases were results of preventable external injuries, which mostly affected the young productive age group. A large number of cases had permanent impairment of mobility, bowel, bladder and sexual functions. Psychological reactions of anxiety and denial were most frequently encountered in initial stages, but gradually declined in successive stages of rehabilitation. Individuals with independent vocations were psychologically and socially well adjusted.

  16. 2. International conference. Radiobiological consequences of nuclear accidents; Russian-Norwegian Satellite Symposium on nuclear accidents, radioecology and health. Abstracts. Part 2

    International Nuclear Information System (INIS)

    Materials on radiobiological effect of ionizing radiation under emergency situations are presented. The radiation contamination of environmental media after the Chernobyl NPP accident (ground, earth and water ecological systems), effect of external and internal irradiation on the inhabitants of the region are estimated. Time characteristic of radiation risk of originating tumors and genetic injuries is given

  17. LISA Long-Arm Interferometry

    Science.gov (United States)

    Thorpe, James I.

    2009-01-01

    An overview of LISA Long-Arm Interferometry is presented. The contents include: 1) LISA Interferometry; 2) Constellation Design; 3) Telescope Design; 4) Constellation Acquisition; 5) Mechanisms; 6) Optical Bench Design; 7) Phase Measurement Subsystem; 8) Phasemeter Demonstration; 9) Time Delay Interferometry; 10) TDI Limitations; 11) Active Frequency Stabilization; 12) Spacecraft Level Stabilization; 13) Arm-Locking; and 14) Embarassment of Riches.

  18. Strong Force

    CERN Multimedia

    Without the strong force, there could be no life. The carbon in living matter is synthesised in stars via the strong force. Lighter atomic nuclei become bound together in a process called nuclear fusion. A minor change in this interaction would make life impossible. As its name suggests, the strong force is the most powerful of the 4 forces, yet its sphere of influence is limited to within the atomic nucleus. Indeed it is the strong force that holds together the quarks inside the positively charged protons. Without this glue, the quarks would fly apart repulsed by electromagnetism. In fact, it is impossible to separate 2 quarks : so much energy is needed, that a second pair of quarks is produced. Text for the interactive: Can you pull apart the quarks inside a proton?

  19. Robotic Arm Biobarrier Cable

    Science.gov (United States)

    2008-01-01

    This image, taken by the Surface Stereo Imager on NASA's Phoenix Mars Lander on the 14th Martian day of the mission (June 7, 2008), shows the cable that held the Robotic Arm's biobarrier in place during flight has snapped. The cable's springs retracted to release the biobarrier right after landing. To the lower right of the image a spring is visible. Extending from that spring is a length of cable that snapped during the biobarrier's release. A second spring separated from the cable when it snapped and has been photographed on the ground under the lander near one of the legs. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  20. Segmental and kinetic contributions in vertical jumps performed with and without an arm swing.

    Science.gov (United States)

    Feltner, Michael E; Bishop, Elijah J; Perez, Cassandra M

    2004-09-01

    To determine the contributions of the motions of the body segments to the vertical ground reaction force (Fz), the joint torques produced by the leg muscles, and the time course of vertical velocity generation during a vertical jump, 15 men were videotaped performing countermovement vertical jumps from a force plate with and without an arm swing. Linear kinematic, Fz, and joint torque data were computed and compared using repeated measures analysis of variance. Maximum jump height was significantly larger in the arm swing jumps compared to the no arm swing jumps and was due to both a higher height of the center of mass (CM) at takeoff (54%) and a larger vertical velocity of the CM at takeoff (46%). The net vertical impulse created during the propulsive phase of the arm swing jumps was greater due to a trend of an increased duration (0.021 s) of the propulsive phase and not to larger average values of Fz. In the arm swing jumps, the arm motion resulted in the arms making a larger maximal contribution to Fz during the middle of the propulsive phase and decreased the negative contribution of the trunk-head and thigh to Fz late in the propulsive phase. Last, the arm swing decreased the extensor torques at the hip (13%), knee (10%), and ankle (10%) early in the propulsive phase but augmented these same extensor torques later in the propulsive phase.

  1. The objective qualification of non-international armed conflicts: A Colombian case study

    Directory of Open Access Journals (Sweden)

    Sebastian Machado

    2012-02-01

    Full Text Available

    Armed conflict has raged in Colombia since at least the 1960’s, involving governmental forces, rebel groups, and paramilitary forces. The Uribe government (2002-2010 declared that Colombia was not in a ‘state of armed conflict’ but was rather facing a ‘terrorist threat’. This declaration was done in fear of conferring a political status to the armed groups, and most particularly, in fear that a recognition of armed conflict would open the possibility of endowing the Revolutionary Armed Forces of Colombia (FARC with a ‘belligerency status’. From a legal point of view, the government’s fears were unfounded, since contemporary international humanitarian law does not require a formal for a situation to qualify as armed conflict. During the Uribe administration, efforts were made by the Ministry of Defense to identify operational rules of engagement with precision, violations of international humanitarian law were publicly denounced, and the apex courts adjudicated on issues of international humanitarian law. This seemingly paradoxical situation illustrates the importance of the objective definition of armed conflict, which has been a defining characteristic of international humanitarian law since 1949.

     

  2. New mitral annular force transducer optimized to distinguish annular segments and multi-plane forces.

    Science.gov (United States)

    Skov, Søren Nielsen; Røpcke, Diana Mathilde; Ilkjær, Christine; Rasmussen, Jonas; Tjørnild, Marcell Juan; Jimenez, Jorge H; Yoganathan, Ajit P; Nygaard, Hans; Nielsen, Sten Lyager; Jensen, Morten Olgaard

    2016-03-21

    Limited knowledge exists about the forces acting on mitral valve annuloplasty repair devices. The aim of this study was to develop a new mitral annular force transducer to measure the forces acting on clinically used mitral valve annuloplasty devices. The design of an X-shaped transducer in the present study was optimized for simultaneous in- and out-of-plane force measurements. Each arm was mounted with strain gauges on four circumferential elements to measure out-of-plane forces, and the central parts of the X-arms were mounted with two strain gauges to measure in-plane forces. A dedicated calibration setup was developed to calibrate isolated forces with tension and compression for in- and out-of-plane measurements. With this setup, it was possible with linear equations to isolate and distinguish measured forces between the two planes and minimize transducer arm crosstalk. An in-vitro test was performed to verify the crosstalk elimination method and the assumptions behind it. The force transducer was implanted and evaluated in an 80kg porcine in-vivo model. Following crosstalk elimination, in-plane systolic force accumulation was found to be in average 4.0±0.1N and the out-of-plane annular segments experienced an average force of 1.4±0.4N. Directions of the systolic out-of-plane forces indicated movements towards a saddle shaped annulus, and the transducer was able to measure independent directional forces in individual annular segments. Further measurements with the new transducer coupled with clinical annuloplasty rings will provide a detailed insight into the biomechanical dynamics of these devices. PMID:26903412

  3. New mitral annular force transducer optimized to distinguish annular segments and multi-plane forces.

    Science.gov (United States)

    Skov, Søren Nielsen; Røpcke, Diana Mathilde; Ilkjær, Christine; Rasmussen, Jonas; Tjørnild, Marcell Juan; Jimenez, Jorge H; Yoganathan, Ajit P; Nygaard, Hans; Nielsen, Sten Lyager; Jensen, Morten Olgaard

    2016-03-21

    Limited knowledge exists about the forces acting on mitral valve annuloplasty repair devices. The aim of this study was to develop a new mitral annular force transducer to measure the forces acting on clinically used mitral valve annuloplasty devices. The design of an X-shaped transducer in the present study was optimized for simultaneous in- and out-of-plane force measurements. Each arm was mounted with strain gauges on four circumferential elements to measure out-of-plane forces, and the central parts of the X-arms were mounted with two strain gauges to measure in-plane forces. A dedicated calibration setup was developed to calibrate isolated forces with tension and compression for in- and out-of-plane measurements. With this setup, it was possible with linear equations to isolate and distinguish measured forces between the two planes and minimize transducer arm crosstalk. An in-vitro test was performed to verify the crosstalk elimination method and the assumptions behind it. The force transducer was implanted and evaluated in an 80kg porcine in-vivo model. Following crosstalk elimination, in-plane systolic force accumulation was found to be in average 4.0±0.1N and the out-of-plane annular segments experienced an average force of 1.4±0.4N. Directions of the systolic out-of-plane forces indicated movements towards a saddle shaped annulus, and the transducer was able to measure independent directional forces in individual annular segments. Further measurements with the new transducer coupled with clinical annuloplasty rings will provide a detailed insight into the biomechanical dynamics of these devices.

  4. Weak Force

    CERN Multimedia

    Without the weak force, the sun wouldn't shine. The weak force causes beta decay, a form of radioactivity that triggers nuclear fusion in the heart of the sun. The weak force is unlike other forces: it is characterised by disintegration. In beta decay, a down quark transforms into an up quark and an electron is emitted. Some materials are more radioactive than others because the delicate balance between the strong force and the weak force varies depending on the number of particles in the atomic nucleus. We live in the midst of a natural radioactive background that varies from region to region. For example, in Cornwall where there is a lot of granite, levels of background radiation are much higher than in the Geneva region. Text for the interactive: Move the Geiger counter to find out which samples are radioactive - you may be surprised. It is the weak force that is responsible for the Beta radioactivity here. The electrons emitted do not cross the plastic cover. Why do you think there is some detected radioa...

  5. EMG feedback tasks reduce reflexive stiffness during force and position perturbations

    NARCIS (Netherlands)

    Forbes, P.A.; Happee, R.; Van der Helm, F.C.T.; Schouten, A.C.

    2011-01-01

    Force and position perturbations are widely applied to identify muscular and reflexive contributions to posture maintenance of the arm. Both task instruction (force vs. position) and the inherently linked perturbation type (i.e., force perturbations-position task and position perturbations-force tas

  6. Radiobiology in clinical radiation therapy part II: current practice and new horizons

    International Nuclear Information System (INIS)

    Objective: This course is designed for residents in radiation oncology, preparing for their boards. It includes the physics and chemistry of the absorption of radiation, a description of the biological systems used to obtain a quantitative relationship between dose and biological effect, as well as a review of the basic principles in radiation biology that have been established. The multifraction regimens used in conventional radiotherapy were developed empirically, but can be understood in terms of radiobiological principles. Dividing the dose into many fractions reduces biological effectiveness due to repair of sublethal damage; this occurs in both tumors and normal tissues. Fractionation allows re-oxygenation to occur in tumors and so increases the effectiveness of a given total dose. Fractionation also leads to sensitization by reassortment of cycling tumor cells into radiosensitive phases of the cycle. Laboratory research also provides a rationale for modifications of existing fractionation protocols. The dose response relationship for late responding tissues is more 'curved' than for acute or early effects. Consequently the use of multiple fractions allows a greater separation of early and late effects in normal tissues. This has led to the introduction of hyperfractionation and accelerated treatment. Both involve two treatments per day (BID) but based on quite different rationales. The limitation of protraction is cell proliferation in the tumor, which may be accelerated as the tumor shrinks. Measurements of cell kinetics can identify fast growing tumors that may benefit from accelerated treatment. Hypoxia was early identified as a cause of resistance to cell killing x-rays. This led to development of electron affinic compounds as radiosensitizers of hypoxic cells. The new trend is the development of bioreductive drugs that are specifically cytotoxic to hypoxic cells i.e. hypoxic cytotoxins, but which still need to be combined with radiation. Fast neutrons

  7. Radiobiological evaluation of forward and inverse IMRT using different fractionations for head and neck tumours

    International Nuclear Information System (INIS)

    To quantify the radiobiological advantages obtained by an Improved Forward Planning technique (IFP) and two IMRT techniques using different fractionation schemes for the irradiation of head and neck tumours. The conventional radiation therapy technique (CONVT) was used here as a benchmark. Seven patients with head and neck tumours were selected for this retrospective planning study. The PTV1 included the primary tumour, PTV2 the high risk lymph nodes and PTV3 the low risk lymph nodes. Except for the conventional technique where a maximum dose of 64.8 Gy was prescribed to the PTV1, 70.2 Gy, 59.4 Gy and 50.4 Gy were prescribed respectively to PTV1, PTV2 and PTV3. Except for IMRT2, all techniques were delivered by three sequential phases. The IFP technique used five to seven directions with a total of 15 to 21 beams. The IMRT techniques used five to nine directions and around 80 segments. The first, IMRT1, was prescribed with the conventional fractionation scheme of 1.8 Gy per fraction delivered in 39 fractions by three treatment phases. The second, IMRT2, simultaneously irradiated the PTV2 and PTV3 with 59.4 Gy and 50.4 Gy in 28 fractions, respectively, while the PTV1 was boosted with six subsequent fractions of 1.8 Gy. Tissue response was calculated using the relative seriality model and the Poisson Linear-Quadratic-Time model to simulate repopulation in the primary tumour. The average probability of total tumour control increased from 38% with CONVT to 80% with IFP, to 85% with IMRT1 and 89% with IMRT2. The shorter treatment time and larger dose per fraction obtained with IMRT2 resulted in an 11% increase in the probability of control in the PTV1 with respect to IFP and 7% relatively to IMRT1 (p < 0.05). The average probability of total patient complications was reduced from 80% with CONVT to 61% with IFP and 31% with IMRT. The corresponding probability of complications in the ipsilateral parotid was 63%, 42% and 20%; in the contralateral parotid it was 50%, 20

  8. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  9. Development of a multisensory arm for process monitoring in Robot Assisted Polishing

    DEFF Research Database (Denmark)

    Pilny, Lukas; Dalla Costa, Giuseppe; Bissacco, Giuliano;

    2015-01-01

    A multisensory polishing arm with integrated three component force sensor, a miniature acoustic emission (AE) sensor and an accelerometer was developed for process monitoring in Robot Assisted Polishing (RAP) process. The arm design was optimized for integration of a force and an AE sensor....... The force sensor, consisted of semiconductor and metallic strain gauges, was calibrated by means of static application of defined loads. The sensor performance in a dynamic application was subsequently verified by comparison with a reference calibrated dynamometer on a dedicated test rig. To compensate...

  10. The effects of the arm swing on biomechanical and physiological aspects of roller ski skating.

    Science.gov (United States)

    Hegge, Ann Magdalen; Ettema, Gertjan; de Koning, Jos J; Rognstad, Asgeir Bakken; Hoset, Martin; Sandbakk, Øyvind

    2014-08-01

    This study analyzed the biomechanical and physiological effects of the arm swing in roller ski skating, and compared leg-skating (i.e. ski skating without poles) using a pronounced arm swing (SWING) with leg-skating using locked arms (LOCKED). Sixteen elite male cross-country skiers performed submaximal stages at 10, 15 and 20kmh(-1) on a 2% inclined treadmill in the two techniques. SWING demonstrated higher peak push-off forces and a higher force impulse at all speeds, but a longer cycle length only at the highest speed (all Pski skating increases the ski forces and aerobic energy cost at low and moderate speeds, whereas the greater forces at high speed lead to a longer cycle length and smaller anaerobic contribution.

  11. DOE life-span radiation effects studies in experimental animals at University of Utah Division of Radiobiology

    International Nuclear Information System (INIS)

    The Radiobiology Laboratory at the University of Utah compared the long-term biological effects of 226Ra and 239Pu in adult beagles. The program includes the investigation of other radionuclides. More recently, groups of juvenile and aged beagles were added to the study to investigate the influence of age at exposure. These studies involved single intravenous injection of radionuclides to small groups of beagles, in graded doses from levels at which no effects were expected up to levels where a 100% incidence of bone tumors was sometimes found. Some of the principal effects were bone tumors, fractures, and other skeletal alterations observed radiographically and histologically; emphasis was placed on the detection of precancerous changes, hematological changes, and changes related to aging. Emphasis was also placed on metabolic and autoradiographic studies necessary for good radiation dosimetry

  12. DEGRO practical guidelines for radiotherapy of non-malignant disorders. Part I: physical principles, radiobiological mechanisms, and radiogenic risk

    Energy Technology Data Exchange (ETDEWEB)

    Reichl, Berthold [Hospital Weiden, Department of Radiotherapy and Radiation Oncology, Weiden (Germany); Block, Andreas [Hospital Dortmund, Institute for Medical Radiation Physics and Radiation Protection, Dortmund (Germany); Schaefer, Ulrich [Lippe Hospital, Dept. of Radiotherapy, Lemgo (Germany); Bert, Christoph; Mueller, Reinhold [University Hospitals Erlangen, Dept. of Radiation Oncology, Erlangen (Germany); Jung, Horst [University Hospital Hamburg-Eppendorf, Dept. of Radiotherapy and Radiation Oncology, Hamburg (Germany); Roedel, Franz [University Hospital Goethe-University, Dept. of Radiotherapy and Oncology, Frankfurt am Main (Germany); Collaboration: the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD)

    2015-09-15

    Synopsis of the introductory paragraph of the DEGRO consensus S2e-guideline recommendations for the radiotherapy of benign disorders, including physical principles, radiobiological mechanisms, and radiogenic risk. This work is based on the S2e-guideline recommendations published November 14, 2013. The basic principles of radiation physics and treatment delivery, evaluation of putative underlying radiobiological mechanisms, and the assessment of genetic and cancer risk following low-dose irradiation will be presented. Radiation therapy of benign diseases is performed according to similar physical principles as those governing treatment of malignant diseases in radiation oncology, using the same techniques and workflows. These methods comprise usage of orthovoltage X-ray units, gamma irradiation facilities, linear accelerators (LINACs), and brachytherapy. Experimental in vitro and in vivo models recently confirmed the clinically observed anti-inflammatory effect of low-dose X-irradiation, and implicated a multitude of radiobiological mechanisms. These include modulation of different immunological pathways, as well as the activities of endothelial cells, mono- and polymorphonuclear leukocytes, and macrophages. The use of effective dose for radiogenic risk assessment and the corresponding tumor incidence rate of 5.5 %/Sv are currently controversially discussed. Some authors argue that the risk of radiation-induced cancers should be estimated on the basis of epidemiological data. However, such data are rarely available at present and associated with high variability. Current radiobiological studies clearly demonstrate a therapeutic effectiveness of radiation therapy used to treat benign diseases and implicate various molecular mechanisms. Radiogenic risks should be taken into account when applying radiation treatment for benign diseases. (orig.) [German] Zusammenfassung des einfuehrenden Kapitels der DEGRO-S2e-Leitlinie zur Strahlentherapie gutartiger Erkrankungen

  13. Neutron field produced by 25 MeV deuteron on thick beryllium for radiobiological study; energy spectrum.

    Science.gov (United States)

    Takada, Masashi; Mihara, Erika; Sasaki, Michiya; Nakamura, Takashi; Honma, Toshihiko; Kono, Koji; Fujitaka, Kazunobu

    2004-01-01

    Biological data is necessary for estimation of protection from neutrons, but there is a lack of data on biological effects of neutrons for radiation protection. Radiological study on fast neutrons has been done at the National Institute of Radiological Sciences. An intense neutron source has been produced by 25 MeV deuterons on a thick beryllium target. The neutron energy spectrum, which is essential for neutron energy deposition calculation, was measured from thermal to maximum energy range by using an organic liquid scintillator and multi-sphere moderated 3He proportional counters. The spectrum of the gamma rays accompanying the neutron beam was measured simultaneously with the neutron spectrum using the organic liquid scintillator. The transmission by the shield of the spurious neutrons originating from the target was measured to be less than 1% by using the organic liquid scintillator placed behind the collimator. The measured neutron energy spectrum is useful in dose calculations for radiobiology studies.

  14. ARM Lead Mentor Selection Process

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, DL

    2013-03-13

    The ARM Climate Research Facility currently operates more than 300 instrument systems that provide ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as Instrument Mentors. Instrument Mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets.

  15. New Horizons and New Strategies in Arms Control

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J. editor

    1998-12-04

    In the last ten years, since the break-up of the Soviet Union, remarkable progress in arms control and disarmament has occurred. The Nuclear Non-Proliferation Treaty (NPT), the completion of the Comprehensive Test Ban Treaty (CTBT), and the Chemical Weapons Treaty (CWC) are indicative of the great strides made in the non- proliferation arena. Simultaneously, the Intermediate Nuclear Forces Treaty (INF), the Conventional Forces Treaty in Europe (CFE), and the Strategic Arms Reduction Treaties (START), all associated with US-Soviet Union (now Russia) relations have assisted in redefining European relations and the security landscape. Finally, it now appears that progress is in the offing in developing enhanced compliance measures for the Biological and Toxin Weapons Convention (BTWC). In sum, all of these achievements have set the stage for the next round of arms control activities, which may lead to a much broader, and perhaps more diffused multilateral agenda. In this new and somewhat unpredictable international setting, arms control and disarmament issues will require solutions that are both more creative and innovative than heretofore.

  16. Arménie

    Directory of Open Access Journals (Sweden)

    François Verdier

    2012-04-01

    Full Text Available L’Arménie est une petite république du Caucase, à la limite sud–est de l’Europe, qui a gagné son autonomie en 1990 après l’ouverture du bloc soviétique. Le nouveau Ministère du Patrimoine a sollicité la coopération de la France pour mettre en place une nouvelle politique culturelle. Tout d’abord, une évaluation sur place de la situation dans les domaines des monuments historiques, de l’archéologie et de l’Inventaire a permis d’envisager les réponses à proposer. Pour la demande d’informatisation des dossiers d’inventaire déjà réalisés sous l’autorité de l’Académie de Saint–Petersbourg, nous avons proposé de former des chercheurs arméniens aux méthodes et techniques de l’Inventaire général. L’accueil d’une stagiaire pendant trois mois au service régional de l’Inventaire de Haute–Normandie a été suivi par la mise en place d’un équipement informatique à Yérévan, puis par l’accueil et la formation de techniciens informaticiens et photographes arméniens. De retour dans leur pays ils ont commencé à remettre en place un service d’inventaire dont le programme comprend la création d’une base de données patrimoniales, le recensement de la ville de Yérévan, la numérisation d’images pour la publication d’un indicateur du patrimoine et la préparation de dossiers de protection au titre du patrimoine mondial.The Armenian heritage comprises both archaeological remains of towns destroyed by never–ending wars and a number of old churches from the eleventh and twelfth centuries. Yerevan, the capital of Armenia, was founded three thousand years ago and is one of Europe’s oldest capitals. From 1925 it has developed according to an ambitious urban planning project. After the major political upheavals of 1991, a special ministry was created to look after the architectural and movable heritage of the country and to promote the Armenian national identity. A mission in Yerevan was

  17. Radiobiological parameters of four glioblastoma compared to four other histological types of human tumor xenografts in nude mice

    International Nuclear Information System (INIS)

    Purpose/Objective: Glioblastoma Multiforme (GBM) is a highly malignant tumor of the central nervous system with aggressive biological behavior and a fatal clinical outcome. Several radiobiological parameters might contribute to these poor results. In this study, we investigated seventeen biological parameters of four GBM xenografts and compared the results with four other histological types of human tumor xenografts in nude mice. Methods and Materials: Most of the xenografts retained the individual histological features of their original tumor types. Four GBM xenografts (U87, HP555, MMC1 and HGL21), two squamous cell carcinomas (SCC21 and FaDu), one soft tissue sarcoma (STS26T), and colon cancer (HCT15) xenografts were used. The tumors were implanted in the hindleg of 5-6 Gy WBI nude mice. The following parameters were investigated for most of the xenografts: fractionated TCD50 (the dose of radiation which controls 50% of the tumors) using 30 fractions in 15 days. The parameters pO2, IFP (interstitial fluid pressure), Tpot, SF2 (plastic and Courtenay), PE (plating efficiency), D0, GSH, TCD50 single dose in oxic and hypoxic conditions, the rate of metastasis in SCID mice, VDT (volume doubling time), spontaneous apoptosis, induced apoptosis after 30 and 60 Gy and p53 over-expression. Results: Using the t-test, there was a significantly less spontaneous apoptosis in GBM xenografts when compared with the other histological types. However, no significant difference was found between both groups of xenografts in the remaining biological parameters investigated. Conclusion: These data demonstrate that, with the exception of spontaneous apoptosis, no significant difference was found in fifteen biological parameters between GBM xenografts and the other histological types implanted into the subcutaneous tissue of nude mice. The data suggests that the classical radiobiological parameters cannot explain the poor response of GBM to radiation. Supported by NCI Grant CA13311

  18. The coordinate system for force control.

    Science.gov (United States)

    Saha, Devjani J; Hu, Xiao; Perreault, Eric; Murray, Wendy; Mussa-Ivaldi, Ferdinando A

    2015-03-01

    The primary objective of this study was to establish the coordinate frame for force control by observing how parameters of force that are not explicitly specified by a motor task vary across the workspace. We asked subjects to apply a force of a specific magnitude with their hand. Subjects could complete the task by applying forces in any direction of their choice in the transverse plane. They were tested with the arm in seven different configurations. To estimate whether contact forces are represented in extrinsic or intrinsic coordinates, we applied the parallel transport method of differential geometry to the net joint torques applied during the task. This approach allowed us to compare the force variability observed at different arm configurations with the force variability that would be expected if the control system were applying an invariant pattern of joint torques at the tested configurations. The results indicate that for the majority of the subjects, the predominant pattern was consistent with an invariant representation in joint coordinates. However, two out of eleven subjects also demonstrated a preference for extrinsic representation. These findings suggest that the central nervous system can represent contact forces in both coordinate frames, with a prevalence toward intrinsic representations.

  19. 武警总医院住院患者麻醉药品用药分析%Analysis on the application of narcotic drugs among the in-patients of General Hospital of Chinese People's Armed Police Forces 2007~2009

    Institute of Scientific and Technical Information of China (English)

    闫赋琴; 程志英; 吕娟丽; 李冬梅

    2012-01-01

    目的 分析武警总医院住院患者麻醉药品的应用情况.方法 收集武警总医院2007年~2009年住院临床药房麻醉药品品种、用量.运用药物频度分析法对麻醉药品应用情况进行回顾性统计分析与评价.结果 2007年和2008年DDDs 值排序前3位的均是芬太尼注射液、盐酸羟考酮控释片和哌替啶注射液;2009年DDDs 值排序前3位的是芬太尼注射液、注射用盐酸瑞芬太尼和哌替啶注射液.芬太尼注射液用量最大,口服镇痛药及芬太尼透皮贴剂使用量迅速增长.结论 武警总医院麻醉药品使用基本合理,符合WHO推荐的癌痛治疗原则.%Objective To analyze the application of narcotic drugs among the in-patients of General Hospital of Chinese People s Armed Police Forces 2007~2009. Methods The special account books of varieties and dosages of narcotic drugs preserved in the clinical pharmacy and the related data provided by the microcomputer management system 2007~2009 were analyzed. Defined daily dose (DDD) was adopted as a statistical index. Frequency of drug use (DDDs) and drug utilization index (DUI) were calculated. Results The top three narcotic drugs in the DDDs sequence were injection of fentanyl, controlled-release tablet of oxycodone hydrochloride, and injection of pethidine in 2007 and 2008, and were fentanyl injection, injection of remifentanil, and pethidine hydrochloride injection in 2009 respectively. The drug with the highest dosage was fentanyl injection. And the amount of oral analgesics and transdermal fentanyl grew rapidly year after year. Conclusion The use of narcotic drugs in this hospital is rational on the whole, in line with the principles of cancer treatment recommended by WHO.

  20. ARM Standards Policy Committee Report

    Energy Technology Data Exchange (ETDEWEB)

    Cialella, A; Jensen, M; Koontz, A; McFarlane, S; McCoy, R; Monroe, J; Palanisamy, G; Perez, R; Sivaraman, C

    2012-09-19

    Data and metadata standards promote the consistent recording of information and are necessary to ensure the stability and high quality of Atmospheric Radiation Measurement (ARM) Climate Research Facility data products for scientific users. Standards also enable automated routines to be developed to examine data, which leads to more efficient operations and assessment of data quality. Although ARM Infrastructure agrees on the utility of data and metadata standards, there is significant confusion over the existing standards and the process for allowing the release of new data products with exceptions to the standards. The ARM Standards Policy Committee was initiated in March 2012 to develop a set of policies and best practices for ARM data and metadata standards.

  1. [Apothecaries' arms of Voltaire's family].

    Science.gov (United States)

    Chaigneau, M

    1998-01-01

    Apothecaries of Voltaire's family can be divided into two groups. Marceton Family: Claude Marceton, Hierosme and Pierre Testefolle, from Thouars. Arouet family: Jehan Arouet, Pierre Rochard and Jean Gougeard. Five of those apothecaries beand arms. PMID:11625327

  2. Relative Contribution of Arms and Legs in 30 s Fully Tethered Front Crawl Swimming

    Directory of Open Access Journals (Sweden)

    Pedro G. Morouço

    2015-01-01

    Full Text Available The relative contribution of arm stroke and leg kicking to maximal fully tethered front crawl swimming performance remains to be solved. Twenty-three national level young swimmers (12 male and 11 female randomly performed 3 bouts of 30 s fully tethered swimming (using the whole body, only the arm stroke, and only the leg kicking. A load-cell system permitted the continuous measurement of the exerted forces, and swimming velocity was calculated from the time taken to complete a 50 m front crawl swim. As expected, with no restrictions swimmers were able to exert higher forces than that using only their arm stroke or leg kicking. Estimated relative contributions of arm stroke and leg kicking were 70.3% versus 29.7% for males and 66.6% versus 33.4% for females, with 15.6% and 13.1% force deficits, respectively. To obtain higher velocities, male swimmers are highly dependent on the maximum forces they can exert with the arm stroke (r=0.77, P<0.01, whereas female swimmers swimming velocity is more related to whole-body mean forces (r=0.81, P<0.01. The obtained results point that leg kicking plays an important role over short duration high intensity bouts and that the used methodology may be useful to identify strength and/or coordination flaws.

  3. The Financial Arm Of The FARC: A Threat Finance Perspective

    OpenAIRE

    Thomas Cook

    2011-01-01

    The FARC (Fuerzas Armadas Revolucionarias de Colombia or Revolutionary Armed Forces of Colombia) transformed from a traditional guerrilla group into a full-fledged insurgency because of its ability to effectively convert the proceeds derived from illegal narcotic trafficking into operational funds. Those financial capabilities allowed the FARC to challenge government authority in large swathes of the Colombian state. The FARC moved into the drug trade, initially controlling production territo...

  4. Treatment of Glioma Using neuroArm Surgical System

    OpenAIRE

    Yaser Maddahi; Kourosh Zareinia; Liu Shi Gan; Christina Sutherland; Sanju Lama; Sutherland, Garnette R.

    2016-01-01

    The use of robotic technology in the surgical treatment of brain tumour promises increased precision and accuracy in the performance of surgery. Robotic manipulators may allow superior access to narrow surgical corridors compared to freehand or conventional neurosurgery. This paper reports values and ranges of tool-tissue interaction forces during the performance of glioma surgery using an MR compatible, image-guided neurosurgical robot called neuroArm. The system, capable of microsurgery and...

  5. Haptic stabilization of posture: changes in arm proprioception and cutaneous feedback for different arm orientations

    Science.gov (United States)

    Rabin, E.; Bortolami, S. B.; DiZio, P.; Lackner, J. R.

    1999-01-01

    Postural sway during quiet stance is attenuated by actively maintained contact of the index finger with a stationary surface, even if the level of applied force (proprioceptive information about the hand and arm can serve as an active sensor of body position relative to the point of contact. A geometric analysis of the relationship between hand and torso displacement during body sway led to the prediction that arm and hand proprioceptive and finger somatosensory information about body sway would be maximized with finger contact in the plane of body sway. Therefore, the most postural stabilization should be possible with such contact. To test this analysis, subjects touched a laterally versus anteriorly placed surface while in each of two stances: the heel-to-toe tandem Romberg stance that reduces medial-lateral stability and the heel-to-heel, toes-outward, knees-bent, "duck stance" that reduces fore-aft stability. Postural sway was always least with finger contact in the unstable plane: for the tandem stance, lateral fingertip contact was significantly more effective than frontal contact, and, for the duck stance, frontal contact was more effective than lateral fingertip contact. Force changes at the fingertip led changes in center of pressure of the feet by approximately 250 ms for both fingertip contact locations for both test stances. These results support the geometric analysis, which showed that 1) arm joint angles change by the largest amount when fingertip contact is maintained in the plane of greatest sway, and 2) the somatosensory cues at the fingertip provide both direction and amplitude information about sway when the finger is contacting a surface in the unstable plane.

  6. A influência francesa na estruturação da escola de educação física da Força Pública de São Paulo, Brasil (1906-1914 = The French Influence in the Structuring of the School of Physical Education of the Armed Forces of Sao Paulo, Brazil (1906-1914

    Directory of Open Access Journals (Sweden)

    Daniel Barsottini

    2013-10-01

    ário de uma missão militar francesa que tinha o interesse central na modernização da polícia paulista, a partir de demandas políticas e econômicas do contexto da época. Observamos também que a partir desta influência criou-se uma tradição representada por uma cultura de ginástica, lutas, esgrima, e dança.----------------------------------------------------------------The objective of this study was to describe the French cultural influence in the field of Physical Education in the context of the Armed Forces of Sao Paulo in the early 20th, but also analyzed the political demands of the state government in the organization of this school. Regarding the methodological procedures, there was a documentary research about the theme, which was characterized by collecting data for research on the structure of the School of Physical Education of the Armed Forces of Sao Paulo (1906-1914. These documents, consisting of books, tracts, letters, journals and abstracts were collected at the Museum of Military Police of São Paulo. It concluded that the formation of this school was a secondary goal of a French military mission, because the main objective of São Paulo was the modernization of the police in terms of training and equipment, from political and economic demands of the context of the time. Also observed this influence has created a tradition represented by a culture of gymnastics, martial arts, fencing, and dancing.

  7. Autonomous sensor-based dual-arm satellite grappling

    Science.gov (United States)

    Wilcox, Brian; Tso, Kam; Litwin, Todd; Hayati, Samad; Bon, Bruce

    1989-01-01

    Dual-arm satellite grappling involves the integration of technologies developed in the Sensing and Perception (S&P) Subsystem for object acquisition and tracking, and the Manipulator Control and Mechanization (MCM) Subsystem for dual-arm control. S&P acquires and tracks the position, orientation, velocity, and angular velocity of a slowly spinning satellite, and sends tracking data to the MCM subsystem. MCM grapples the satellite and brings it to rest, controlling the arms so that no excessive forces or torques are exerted on the satellite or arms. A 350-pound satellite mockup which can spin freely on a gimbal for several minutes, closely simulating the dynamics of a real satellite is demonstrated. The satellite mockup is fitted with a panel under which may be mounted various elements such as line replacement modules and electrical connectors that will be used to demonstrate servicing tasks once the satellite is docked. The subsystems are housed in three MicroVAX II microcomputers. The hardware of the S&P Subsystem includes CCD cameras, video digitizers, frame buffers, IMFEX (a custom pipelined video processor), a time-code generator with millisecond precision, and a MicroVAX II computer. Its software is written in Pascal and is based on a locally written vision software library. The hardware of the MCM Subsystem includes PUMA 560 robot arms, Lord force/torque sensors, two MicroVAX II computers, and unimation pneumatic parallel grippers. Its software is written in C, and is based on a robot language called RCCL. The two subsystems are described and test results on the grappling of the satellite mockup with rotational rates of up to 2 rpm are provided.

  8. Design of Robotic Arm Control System Mimics Human Arm Motion

    Directory of Open Access Journals (Sweden)

    A. Salam Al-Ammri

    2013-01-01

    Full Text Available This paper presents a control system to make the robotic hand mimic human hand motion in real time and offline mode. The human hand tracking system is a wearable sensing arm (potentiometers used to determine the position in space and to sense the grasping task of human hand. The maskable sensing arm was designed with same geometrical arrangement of robotic hand that needs to be controlled. The control software of a robot was implemented using Visual Basic and supported with graphical user interface (GUI. The control algorithm depends on joint to joint mapping method to match between the motions at each joint of portable sensing arm with corresponding joint of a robot in order to make the robot mimic the motion.

  9. SU-E-T-399: Determination of the Radiobiological Parameters That Describe the Dose-Response Relations of Xerostomia and Disgeusia From Head and Neck Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To estimate the radiobiological parameters that describe the doseresponse relations of xerostomia and disgeusia from head and neck cancer radiotherapy. To identify the organs that are best correlated with the manifestation of those clinical endpoints. Finally, to evaluate the goodnessof- fit by comparing the model predictions against the actual clinical results. Methods: In this study, 349 head and neck cancer patients were included. For each patient the dose volume histograms (DVH) of parotids (separate and combined), mandible, submandibular glands (separate and combined) and salivary glands were calculated. The follow-up of those patients was recorded at different times after the completion of the treatment (7 weeks, 3, 7, 12, 18 and 24 months). Acute and late xerostomia and acute disgeusia were the clinical endpoints examined. A maximum likelihood fitting was performed to calculate the best estimates of the parameters used by the relative seriality model. The statistical methods of the error distribution, the receiver operating characteristic (ROC) curve, the Pearson's test and the Akaike's information criterion were utilized to assess the goodness-of-fit and the agreement between the pattern of the radiobiological predictions with that of the clinical records. Results: The estimated values of the radiobiological parameters of salivary glands are D50 = 25.2 Gy, γ = 0.52, s = 0.001. The statistical analysis confirmed the clinical validity of those parameters (area under the ROC curve = 0.65 and AIC = 38.3). Conclusion: The analysis proved that the treatment outcome pattern of the patient material can be reproduced by the relative seriality model and the estimated radiobiological parameters. Salivary glands were found to have strong volume dependence (low relative seriality). Diminishing the biologically effective uniform dose to salivary glands below 30 Gy may significantly reduce the risk of complications to the patients irradiated for

  10. SU-E-T-399: Determination of the Radiobiological Parameters That Describe the Dose-Response Relations of Xerostomia and Disgeusia From Head and Neck Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Mavroidis, P; Stathakis, S; Papanikolaou, N [University of Texas Health Science Center, UTHSCSA, San Antonio, TX (United States); Peixoto Xavier, C [University of Coimbra, Coimbra, Coimbra (Portugal); Costa Ferreira, B [University of Aveiro, Coimbra, Coimbra (Portugal); Khouri, L; Carmo Lopes, M do [IPOCFG, EPE, Coimbra, Coimbra (Portugal)

    2014-06-01

    Purpose: To estimate the radiobiological parameters that describe the doseresponse relations of xerostomia and disgeusia from head and neck cancer radiotherapy. To identify the organs that are best correlated with the manifestation of those clinical endpoints. Finally, to evaluate the goodnessof- fit by comparing the model predictions against the actual clinical results. Methods: In this study, 349 head and neck cancer patients were included. For each patient the dose volume histograms (DVH) of parotids (separate and combined), mandible, submandibular glands (separate and combined) and salivary glands were calculated. The follow-up of those patients was recorded at different times after the completion of the treatment (7 weeks, 3, 7, 12, 18 and 24 months). Acute and late xerostomia and acute disgeusia were the clinical endpoints examined. A maximum likelihood fitting was performed to calculate the best estimates of the parameters used by the relative seriality model. The statistical methods of the error distribution, the receiver operating characteristic (ROC) curve, the Pearson's test and the Akaike's information criterion were utilized to assess the goodness-of-fit and the agreement between the pattern of the radiobiological predictions with that of the clinical records. Results: The estimated values of the radiobiological parameters of salivary glands are D50 = 25.2 Gy, γ = 0.52, s = 0.001. The statistical analysis confirmed the clinical validity of those parameters (area under the ROC curve = 0.65 and AIC = 38.3). Conclusion: The analysis proved that the treatment outcome pattern of the patient material can be reproduced by the relative seriality model and the estimated radiobiological parameters. Salivary glands were found to have strong volume dependence (low relative seriality). Diminishing the biologically effective uniform dose to salivary glands below 30 Gy may significantly reduce the risk of complications to the patients irradiated for

  11. Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

    International Nuclear Information System (INIS)

    The aim of this study was to optimize the dosimetric approach and to review the absorbed doses delivered, taking into account radiobiology, in order to identify the optimal methodology for an individualized treatment planning strategy based on 99mTc-macroaggregated albumin (MAA) single photon emission computed tomography (SPECT) images. We performed retrospective dosimetry of the standard TheraSphere registered treatment on 52 intermediate (n = 17) and advanced (i.e. portal vein thrombosis, n = 35) hepatocarcinoma patients with tumour burden < 50 % and without obstruction of the main portal vein trunk. Response was monitored with the densitometric radiological criterion (European Association for the Study of the Liver) and treatment-related liver decompensation was defined ad hoc with a time cut-off of 6 months. Adverse events clearly attributable to disease progression or other causes were not attributed to treatment. Voxel dosimetry was performed with the local deposition method on 99mTc-MAA SPECT images. The reconstruction protocol was optimized. Concordance of 99mTc-MAA and 90Y bremsstrahlung microsphere biodistributions was studied in 35 sequential patients. Two segmentation methods were used, based on SPECT alone (home-made code) or on coregistered SPECT/CT images (IMALYTICS trademark by Philips). STRATOS trademark absorbed dose calculation was validated for 90Y with a single time point. Radiobiology was used introducing other dosimetric variables besides the mean absorbed dose D: equivalent uniform dose (EUD), biologically effective dose averaged over voxel values (BEDave) and equivalent uniform biologically effective dose (EUBED). Two sets of radiobiological parameters, the first derived from microsphere irradiation and the second from external beam radiotherapy (EBRT), were used. A total of 16 possible methodologies were compared. Tumour control probability (TCP) and normal tissue complication probability (NTCP) were derived. The area under the curve (AUC

  12. NASA's Asteroid Redirect Mission (ARM)

    Science.gov (United States)

    Abell, Paul; Mazanek, Dan; Reeves, David; Naasz, Bo; Cichy, Benjamin

    2015-11-01

    The National Aeronautics and Space Administration (NASA) is developing a robotic mission to visit a large near-Earth asteroid (NEA), collect a multi-ton boulder from its surface, and redirect it into a stable orbit around the Moon. Once returned to cislunar space in the mid-2020s, astronauts will explore the boulder and return to Earth with samples. This Asteroid Redirect Mission (ARM) is part of NASA’s plan to advance the technologies, capabilities, and spaceflight experience needed for a human mission to the Martian system in the 2030s. Subsequent human and robotic missions to the asteroidal material would also be facilitated by its return to cislunar space. Although ARM is primarily a capability demonstration mission (i.e., technologies and associated operations), there exist significant opportunities to advance our knowledge of small bodies in the synergistic areas of science, planetary defense, asteroidal resources and in-situ resource utilization (ISRU), and capability and technology demonstrations. In order to maximize the knowledge return from the mission, NASA is organizing an ARM Investigation Team, which is being preceded by the Formulation Assessment and Support Team. These teams will be comprised of scientists, technologists, and other qualified and interested individuals to help plan the implementation and execution of ARM. An overview of robotic and crewed segments of ARM, including the mission requirements, NEA targets, and mission operations, will be provided along with a discussion of the potential opportunities associated with the mission.

  13. Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy.

    Science.gov (United States)

    Held, Kathryn D; Blakely, Eleanor A; Story, Michael D; Lowenstein, Derek I

    2016-06-01

    Although clinical studies with carbon ions have been conducted successfully in Japan and Europe, the limited radiobiological information about charged particles that are heavier than protons remains a significant impediment to exploiting the full potential of particle therapy. There is growing interest in the U.S. to build a cancer treatment facility that utilizes charged particles heavier than protons. Therefore, it is essential that additional radiobiological knowledge be obtained using state-of-the-art technologies and biological models and end points relevant to clinical outcome. Currently, most such ion radiotherapy-related research is being conducted outside the U.S. This article addresses the substantial contributions to that research that are possible at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), which is the only facility in the U.S. at this time where heavy-ion radiobiology research with the ion species and energies of interest for therapy can be done. Here, we briefly discuss the relevant facilities at NSRL and how selected charged particle biology research gaps could be addressed using those facilities. PMID:27195609

  14. The application of multilayer elastic beam in MEMS safe and arming system

    Energy Technology Data Exchange (ETDEWEB)

    Li, Guozhong, E-mail: liguozhong-bit@bit.edu.cn; Shi, Gengchen; Sui, Li [National Lab of Mechatronic Engineering and Control, Beijing Institute of Technology, Beijing 100081, P.R.CHINA (China); Yi, Futing; Wang, Bo [Institute of High Energy Physics Chinese Academy of Sciences, Beijing 100049, P.R.CHINA (China)

    2015-07-15

    In this paper, a new approach for a multilayer elastic beam to provide a driving force and driving distance for a MEMS safe and arming system is presented. In particular this is applied where a monolayer elastic beam cannot provide adequate driving force and driving distance at the same time in limited space. Compared with thicker elastic beams, the bilayer elastic beam can provide twice the driving force of a monolayer beam to guarantee the MEMS safe and arming systems work reliably without decreasing the driving distance. In this paper, the theoretical analysis, numerical simulation and experimental verification of the multilayer elastic beam is presented. The numerical simulation and experimental results show that the bilayer elastic provides 1.8–2 times the driving force of a monolayer, and a method that improves driving force without reducing the driving distance.

  15. Estimation of a Self-Consistent Set of Radiobiological Parameters From Hypofractionated Versus Standard Radiation Therapy of Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pedicini, Piernicola, E-mail: ppiern@libero.it [Service of Medical Physics, Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (Italy); Strigari, Lidia [Laboratory of Medical Physics and Expert Systems, Istituto Nazionale Tumori Regina Elena, Rome (Italy); Benassi, Marcello [Service of Medical Physics, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola (Italy)

    2013-04-01

    Purpose: To determine a self-consistent set of radiobiological parameters in prostate cancer. Methods and Materials: A method to estimate intrinsic radiosensitivity (α), fractionation sensitivity (α/β), repopulation doubling time, number of clonogens, and kick-off time for accelerated repopulation of prostate cancer has been developed. Based on the generalized linear-quadratic model and without assuming the isoeffective hypothesis, the potential applications of the method were investigated using the clinical outcome of biochemical relapse-free survival recently reviewed in the literature. The strengths and limitations of the method, regarding the fitted parameters and 95% confidence intervals (CIs), are also discussed. Results: Our best estimate of α/β is 2.96 Gy (95% CI 2.41-3.53 Gy). The corresponding α value is 0.16 Gy{sup −1} (95% CI 0.14-0.18 Gy{sup −1}), which is compatible with a realistic number of clonogens: 6.5 × 10{sup 6} (95% CI 1.5 × 10{sup 6}-2.1 × 10{sup 7}). The estimated cell doubling time is 5.1 days (95% CI 4.2-7.2 days), very low if compared with that reported in the literature. This corresponds to the dose required to offset the repopulation occurring in 1 day of 0.52 Gy/d (95% CI 0.32-0.68 Gy/d). However, a long kick-off time of 31 days (95% CI 22-41 days) from the start of radiation therapy was found. Conclusion: The proposed analytic/graphic method has allowed the fitting of clinical data, providing a self-consistent set of radiobiological parameters for prostate cancer. With our analysis we confirm a low value for α/β with a correspondingly high value of intrinsic radiosensitivity, a realistic average number of clonogens, a long kick-off time for accelerated repopulation, and a surprisingly fast repopulation that suggests the involvement of subpopulations of specifically tumorigenic stem cells during continuing radiation therapy.

  16. Účinky individuálně navržených programů tělesné přípravy založených na normách americké armády na motorické schopnosti zaměstnanců slovinských ozbrojených sil The effects of individually designed programs of physical training based on US army standards on motor abilities of Slovene armed forces personnel

    Directory of Open Access Journals (Sweden)

    Franc Rožman

    2006-02-01

    Full Text Available Přiměřená fyzická zdatnost je významným aspektem obecné připravenosti ozbrojených sil a nedílnou součástí armádní podpory. Cílem tohoto průzkumu bylo zjistit účinky výcvikového programu, založeného na individuálně přizpůsobené míře intenzity, na motorické schopnosti zaměstnanců slovinských ozbrojených sil (SV. Vzorek zahrnoval 34 členů SV (16 zařazených do experimentální skupiny – ES a 18 do kontrolní skupiny – KS ve věku od 35 do 40 let. Výsledky byly zpracovány pomocí programu SPSS 8.0 pro Windows. Zpracování výsledků bylo prováděno v několika etapách. Nejprve byly stanoveny základní statistické charakteristiky a distribuce individuálních proměnných, byla vypočtena míra střední tendence a stupeň disperze, byla použita metoda pro analýzu s rizikem odchylky 5 %. Výsledky prokázaly, že charakteristického zvýšení úrovně určitých motorických schopností sledovaného souboru lze dosáhnout pomocí ekonomizace výcvikového postupu a individuálně přizpůsobené intenzity výcviku. Statisticky významné rozdíly mezi experimentální a kontrolní skupinou byly zjištěny při měření tělesného tuku (KG, kliků (SK, hrudních předklonů v lehu pokrčmo, běhu na 3200 metrů (T3200M a klidové srdeční frekvence (FSUs. Přestože byl zkoumaný vzorek malý, tyto studie alespoň teoreticky potvrzují potřebu dalšího výzkumu v této oblasti, protože naše důkazy výrazně naznačují účinnost individuálně navržených výcvikových protokolů na tělesnou připravenost zaměstnanců slovinských ozbrojených sil. Adequate physical readiness is a significant aspect of universal armed forces readiness and an integral part of military support. The aim of this research was to ascertain the effect of a training program, based on individually adapted intensity levels, on motor abilities of the Slovene armed forces (SV personnel. The sample of subjects

  17. Scanning ARM Cloud Radar Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Widener, K; Bharadwaj, N; Johnson, K

    2012-06-18

    The scanning ARM cloud radar (SACR) is a polarimetric Doppler radar consisting of three different radar designs based on operating frequency. These are designated as follows: (1) X-band SACR (X-SACR); (2) Ka-band SACR (Ka-SACR); and (3) W-band SACR (W-SACR). There are two SACRs on a single pedestal at each site where SACRs are deployed. The selection of the operating frequencies at each deployed site is predominantly determined by atmospheric attenuation at the site. Because RF attenuation increases with atmospheric water vapor content, ARM's Tropical Western Pacific (TWP) sites use the X-/Ka-band frequency pair. The Southern Great Plains (SGP) and North Slope of Alaska (NSA) sites field the Ka-/W-band frequency pair. One ARM Mobile Facility (AMF1) has a Ka/W-SACR and the other (AMF2) has a X/Ka-SACR.

  18. Management of polytraumatized patients in the resuscitation room Resources, standards and training at the German Armed Forces Hospital in Ulm, Germany%多发性创伤患者的医疗处理——德国乌尔姆市联邦国防军医院的资源、标准和培训

    Institute of Scientific and Technical Information of China (English)

    M.库拉; A.比茨; S.克林格; L.兰波

    2009-01-01

    Continuous quality control of patient management in the resuscitation room has enabled the Federal Armed Forces Medical Centre Ulm to achieve quality standards that are recognized at both the national and the international levels. This is shown in the fact that the hospital is currently being certified as a supraregional trauma center. A major focus has invariably been placed on interdisaplinarity and compliance with nationally and internationally agreed standards. ATLS @ and PHTLS @ algorithms, which are recognized both nationally and internationally, have been successfully adapted to meet the latest requirements such as a multi-slice CT examination of the whole body and thromboelastography. With this background, medical service officers and non-commissioned officers are able to use the knowledge and skills they have acquired in Ulm also on foreign deployments, which require a particularly high level of flexibility and adaptability.%德国乌尔姆市联邦国防军医疗中心复苏病房对患者实行连续质量控制的医疗处理,此项措施使得该中心的医疗处理工作质量达到了国内和国际先进水平,该院最近被认证为跨地区的创伤医疗中心.医院始终不渝地坚持多学科性建设并保持医疗技术处于国内和国际先进水平.按照国内和国际标准制定的ATIS@和PHTLS@规则系统,例如全身多层CT检查、血栓弹性描记法已被用来满足最新的技术需求.在这样的技术背景下,当部队被派往需要高度的灵活性和适应能力的国外部署时,医务人员和非现役军官就能够充分地运用他们在乌尔姆中心医院获得的知识和技能来完成他们所承担的任务.本文介绍了在复苏病房中对多发性创伤患者进行预处理、为复苏医疗组成员提供培训所需要的现有资源,以及对患者的预处理可获得最佳效果的规则方法,此外还介绍了近十年来为达到现有质量标准所做的改进措施.

  19. Stereotypical reaching movements of the octopus involve both bend propagation and arm elongation.

    Science.gov (United States)

    Hanassy, S; Botvinnik, A; Flash, T; Hochner, B

    2015-05-13

    force (<0.0016 for an average strain along the arm of around 0.5). This was not observed and moreover such extremely low value does not seem to be physiologically possible. Hence the assumptions made in applying the dynamic model to behaviors such as static arm stiffening that leads to arm extension through bend propagation and the patterns of activation used to simulate such behaviors should be modified to account for movements combining bend propagation and arm elongation.

  20. Supporting the President's Arms Control and Nonproliferation Agenda: Transparency and Verification for Nuclear Arms Reductions

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, James E [Los Alamos National Laboratory; Meek, Elizabeth [Los Alamos National Laboratory

    2009-01-01

    The President's arms control and nonproliferation agenda is still evolving and the details of initiatives supporting it remain undefined. This means that DOE, NNSA, NA-20, NA-24 and the national laboratories can help define the agenda, and the policies and the initiatives to support it. This will require effective internal and interagency coordination. The arms control and nonproliferation agenda is broad and includes the path-breaking goal of creating conditions for the elimination of nuclear weapons. Responsibility for various elements of the agenda will be widely scattered across the interagency. Therefore an interagency mapping exercise should be performed to identify the key points of engagement within NNSA and other agencies for creating effective policy coordination mechanisms. These can include informal networks, working groups, coordinating committees, interagency task forces, etc. It will be important for NA-20 and NA-24 to get a seat at the table and a functional role in many of these coordinating bodies. The arms control and nonproliferation agenda comprises both mature and developing policy initiatives. The more mature elements such as CTBT ratification and a follow-on strategic nuclear arms treaty with Russia have defined milestones. However, recent press reports indicate that even the START follow-on strategic arms pact that is planned to be complete by the end of 2009 may take significantly longer and be more expansive in scope. The Russians called for proposals to count non-deployed as well as deployed warheads. Other elements of the agenda such as FMCT, future bilateral nuclear arms reductions following a START follow-on treaty, nuclear posture changes, preparations for an international nuclear security summit, strengthened international safeguards and multilateral verification are in much earlier stages of development. For this reason any survey of arms control capabilities within the USG should be structured to address potential needs

  1. ARM Airborne Carbon Measurements VI (ACME VI) Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Biraud, S [Lawrence Berkeley National Laboratory

    2015-12-01

    From October 1 through September 30, 2016, the Atmospheric Radiation Measurement (ARM) Aerial Facility will deploy the Cessna 206 aircraft over the Southern Great Plains (SGP) site, collecting observations of trace-gas mixing ratios over the ARM’s SGP facility. The aircraft payload includes two Atmospheric Observing Systems, Inc., analyzers for continuous measurements of CO2 and a 12-flask sampler for analysis of carbon cycle gases (CO2, CO, CH4, N2O, 13CO2, 14CO2, carbonyl sulfide, and trace hydrocarbon species, including ethane). The aircraft payload also includes instrumentation for solar/infrared radiation measurements. This research is supported by the U.S. Department of Energy’s ARM Climate Research Facility and Terrestrial Ecosystem Science Program and builds upon previous ARM Airborne Carbon Measurements (ARM-ACME) missions. The goal of these measurements is to improve understanding of 1) the carbon exchange at the SGP site, 2) how CO2 and associated water and energy fluxes influence radiative forcing, convective processes and CO2 concentrations over the SGP site, and 3) how greenhouse gases are transported on continental scales.

  2. SA FORCES IN THE SECOND WORLD WAR

    Directory of Open Access Journals (Sweden)

    SADF Archives SADF Archives

    2012-02-01

    Full Text Available UNION DEFENCE FORCE: LAND FORCES Organisation of Union Defence Force (a Pre-War. At the outbreak of war in September, 1939, the armed forces of the Union consisted of a Permanent Force of 352 Officers and 5033 men, and an Active Citizen Force of 918 Officers and 12 572 men. Of the Permanent Force, 173 Officers and 1664 men formed the South African Air Force, 47 Officers and 562 men were members of the South African Artillery and 17 Officers and 1 705 men formed the Special Service Battalion, a unit consisting of men who served on a short-service basis for a minimum of one year. The rest were concerned principally in the supply services and in administering the Active Citizen Force. The latter was roughly parallel to the Territorial Army in Britain, since membership, although nominally compulsory, was in effect restricted to volunteers from among the various age groups called up annually for compulsory registration. Members of the Active Citizen Force were enrolled in units, some of which could show a history dating back to the middle of the last century, and were required to perform 1½ to 4 hours of non-continuous training per week, and 15 days of continuous training, in camp, each year. 

  3. 75 FR 59698 - Federal Advisory Committee; Department of Defense Task Force on the Care, Management, and...

    Science.gov (United States)

    2010-09-28

    ... co-chairs. The estimated number of Task Force meetings is five per year. The Designated Federal... of the Secretary Federal Advisory Committee; Department of Defense Task Force on the Care, Management, and Transition of Recovering Wounded, Ill, and Injured Member of the Armed Forces AGENCY:...

  4. Structural Optimization of Slender Robot Arm Based on Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2012-01-01

    Full Text Available An effective structural optimization method based on a sensitivity analysis is proposed to optimize the variable section of a slender robot arm. The structure mechanism and the operating principle of a polishing robot are introduced firstly, and its stiffness model is established. Then, a design of sensitivity analysis method and a sequential linear programming (SLP strategy are developed. At the beginning of the optimization, the design sensitivity analysis method is applied to select the sensitive design variables which can make the optimized results more efficient and accurate. In addition, it can also be used to determine the scale of moving step which will improve the convergency during the optimization process. The design sensitivities are calculated using the finite difference method. The search for the final optimal structure is performed using the SLP method. Simulation results show that the proposed structure optimization method is effective in enhancing the stiffness of the robot arm regardless of the robot arm suffering either a constant force or variable forces.

  5. Radiobiological long-term accumulation of environmental alpha radioactivity in extracted human teeth and animal bones in Malaysia

    International Nuclear Information System (INIS)

    In this study, the radiobiological analysis of natural alpha emitters in extracted human teeth and animal bones from Malaysia was estimated. The microdistributions of alpha particles in tooth and bone samples were measured using CR-39 alpha-particle track detectors. The lowest and highest alpha emission rates in teeth in the Kedah and Perak states were 0.0080 ± 0.0005 mBq cm−2 and 0.061 ± 0.008 mBq cm−2, whereas those of bones in the Perlis and Kedah states were 0.0140 ± 0.0001 mBq cm−2 and 0.7700 ± 0.0282 mBq cm−2, respectively. The average alpha emission rate in male teeth was 0.0209 ± 0.0008 mBq cm−2, whereas that of female teeth was 0.0199 ± 0.0010 mBq cm−2. The alpha emission rate in teeth is higher in smokers (0.0228 ± 0.0008 mBq cm−2) than in non-smokers (0.0179 ± 0.0008 mBq cm−2). Such difference was found statistically significant (p < 0.01). - Highlights: • Alpha emission rates in teeth from smokers slightly higher than non-smokers. • Difference between alpha rates in male and female tooth not statistically significant. • Alpha particles have the same effect at any age. • Difference between alpha rates in bones was statistically significant

  6. A radiobiology-based inverse treatment planning method for optimisation of permanent l-125 prostate implants in focal brachytherapy

    Science.gov (United States)

    Haworth, Annette; Mears, Christopher; Betts, John M.; Reynolds, Hayley M.; Tack, Guido; Leo, Kevin; Williams, Scott; Ebert, Martin A.

    2016-01-01

    Treatment plans for ten patients, initially treated with a conventional approach to low dose-rate brachytherapy (LDR, 145 Gy to entire prostate), were compared with plans for the same patients created with an inverse-optimisation planning process utilising a biologically-based objective. The ‘biological optimisation’ considered a non-uniform distribution of tumour cell density through the prostate based on known and expected locations of the tumour. Using dose planning-objectives derived from our previous biological-model validation study, the volume of the urethra receiving 125% of the conventional prescription (145 Gy) was reduced from a median value of 64% to less than 8% whilst maintaining high values of TCP. On average, the number of planned seeds was reduced from 85 to less than 75. The robustness of plans to random seed displacements needs to be carefully considered when using contemporary seed placement techniques. We conclude that an inverse planning approach to LDR treatments, based on a biological objective, has the potential to maintain high rates of tumour control whilst minimising dose to healthy tissue. In future, the radiobiological model will be informed using multi-parametric MRI to provide a personalised medicine approach.

  7. Radiobiological long-term accumulation of environmental alpha radioactivity in extracted human teeth and animal bones in Malaysia.

    Science.gov (United States)

    Almayahi, B A; Tajuddin, A A; Jaafar, M S

    2014-03-01

    In this study, the radiobiological analysis of natural alpha emitters in extracted human teeth and animal bones from Malaysia was estimated. The microdistributions of alpha particles in tooth and bone samples were measured using CR-39 alpha-particle track detectors. The lowest and highest alpha emission rates in teeth in the Kedah and Perak states were 0.0080 ± 0.0005 mBq cm(-2) and 0.061 ± 0.008 mBq cm(-2), whereas those of bones in the Perlis and Kedah states were 0.0140 ± 0.0001 mBq cm(-2) and 0.7700 ± 0.0282 mBq cm(-2), respectively. The average alpha emission rate in male teeth was 0.0209 ± 0.0008 mBq cm(-2), whereas that of female teeth was 0.0199 ± 0.0010 mBq cm(-2). The alpha emission rate in teeth is higher in smokers (0.0228 ± 0.0008 mBq cm(-2)) than in non-smokers (0.0179 ± 0.0008 mBq cm(-2)). Such difference was found statistically significant (p < 0.01).

  8. Current (1984) status of the study of 226Ra and 228Ra in humans at the Center for Human Radiobiology

    International Nuclear Information System (INIS)

    The Center for Human Radiobiology has identified 5784 persons by name and type of exposure to 226Ra and 228Ra. Included are 4863 dial painters (mostly women) and non-laboratory employees of the radium dial industry, 410 laboratory workers, 399 persons who received radium for supposed therapeutic effects, and 112 in other categories. Body contents of radium have been measured in 1916 of the dial workers and about one-half of the subjects in the other groups. Bone sarcomas, carcinomas of the paranasal sinuses and mastoids, and deterioration of skeletal tissue are still the only effects unequivocally attributable to internal radium. Excess leukemias have not been observed and other malignancies, if in excess, appear more likely to be related to external gamma radiation or radon than to internal radium. Positive correlations with radium burdens have been found for the incidence of benign exostoses among subjects exposed to radium before age 18 and for shortened latency of ocular cataracts. 27 references, 3 figures, 5 tables

  9. Monte Carlo application based on GEANT4 toolkit to simulate a laser–plasma electron beam line for radiobiological studies

    International Nuclear Information System (INIS)

    We report on the development of a Monte Carlo application, based on the GEANT4 toolkit, for the characterization and optimization of electron beams for clinical applications produced by a laser-driven plasma source. The GEANT4 application is conceived so as to represent in the most general way the physical and geometrical features of a typical laser-driven accelerator. It is designed to provide standard dosimetric figures such as percentage dose depth curves, two-dimensional dose distributions and 3D dose profiles at different positions both inside and outside the interaction chamber. The application was validated by comparing its predictions to experimental measurements carried out on a real laser-driven accelerator. The work is aimed at optimizing the source, by using this novel application, for radiobiological studies and, in perspective, for medical applications. - Highlights: • Development of a Monte Carlo application based on GEANT4 toolkit. • Experimental measurements carried out with a laser-driven acceleration system. • Validation of Geant4 application comparing experimental data with the simulated ones. • Dosimetric characterization of the acceleration system

  10. Radiobiological analysis of region with higher radiation background. The effect of the background on the isomorphism of some enzymes

    International Nuclear Information System (INIS)

    An attempt is made to establish the the time when the prolong impact of slightly increased radiation background get over the compensator mechanisms of living systems. The object of investigation was the ecosystem of the Bay of Wromos (Black Sea, BG) and its surroundings where the flotation slack from an uranium mine was disposed. radioactivity. The following radiobiological picture of the site is obtained according to measurements performed: the alpha-activity of the beach sands is higher than one of the slack and is different in plants; the beta-activity is higher compared to controls in all samples investigated; the gamma spectra show high concentration of the members of U-238 and Th-232 series. The biological effect provoked by this heightened radiation background is studied by means of the isoenzymes as indicators of changes on molecular level. The isoenzyme spectra of lactate dehydrogenase and butyrol dehydrogenase is studied by vertical electrophoresis. The following species are tested: Tettigonia candata charp, Galliptumus italicus, Grillus campestris and Lumbicus terrestrial. An increase in activity and quantity of enzymes as well as changes of their isoenzyme spectra is observed. Calliptumus italicus could be used as a bio indicator of contamination, as it show better separation of the LDH and BDH-isoforms of LDH and BDH, and is more wide-spread. The increase in activity and quantity of some isoenzyme fractions in the conditions of this experiment is one of the possible mechanisms for increase in radioresistance of the living systems. 3 tabs., 2 figs., 8 refs

  11. Current (1984) status of the study of 226Ra and 228Ra in humans at the Center for Human Radiobiology

    International Nuclear Information System (INIS)

    The Center for Human Radiobiology has identified 5784 persons by name and type of exposure to 226Ra and 228Ra. Included are 4863 dial painters (mostly women) and non-laboratory employees of the radium dial industry, 410 laboratory workers, 399 persons who received radium for supposed therapeutic effects, and 112 in other categories. Body contents of radium have been measured in 1916 of the dial workers and about one-half of the subjects in the other groups. Bone sarcomas, carcinomas of the paranasal sinuses and mastoids, and deterioration of skeletal tissue are still the only effects unequivocally attributable to internal radium. Excess leukemias have not been observed and other malignancies, if in excess, appear more likely to be related to external gamma radiation or radon than to internal radium. Positive correlations with radium burdens have been found for the incidence of benign exostoses among subjects exposed to radium before age 18 and for shortened latency of ocular cataracts. 26 references, 3 figures, 5 tables

  12. Monte Carlo application based on GEANT4 toolkit to simulate a laser–plasma electron beam line for radiobiological studies

    Energy Technology Data Exchange (ETDEWEB)

    Lamia, D., E-mail: debora.lamia@ibfm.cnr.it [Institute of Molecular Bioimaging and Physiology IBFM CNR – LATO, Cefalù (Italy); Russo, G., E-mail: giorgio.russo@ibfm.cnr.it [Institute of Molecular Bioimaging and Physiology IBFM CNR – LATO, Cefalù (Italy); Casarino, C.; Gagliano, L.; Candiano, G.C. [Institute of Molecular Bioimaging and Physiology IBFM CNR – LATO, Cefalù (Italy); Labate, L. [Intense Laser Irradiation Laboratory (ILIL) – National Institute of Optics INO CNR, Pisa (Italy); National Institute for Nuclear Physics INFN, Pisa Section and Frascati National Laboratories LNF (Italy); Baffigi, F.; Fulgentini, L.; Giulietti, A.; Koester, P.; Palla, D. [Intense Laser Irradiation Laboratory (ILIL) – National Institute of Optics INO CNR, Pisa (Italy); Gizzi, L.A. [Intense Laser Irradiation Laboratory (ILIL) – National Institute of Optics INO CNR, Pisa (Italy); National Institute for Nuclear Physics INFN, Pisa Section and Frascati National Laboratories LNF (Italy); Gilardi, M.C. [Institute of Molecular Bioimaging and Physiology IBFM CNR, Segrate (Italy); University of Milano-Bicocca, Milano (Italy)

    2015-06-21

    We report on the development of a Monte Carlo application, based on the GEANT4 toolkit, for the characterization and optimization of electron beams for clinical applications produced by a laser-driven plasma source. The GEANT4 application is conceived so as to represent in the most general way the physical and geometrical features of a typical laser-driven accelerator. It is designed to provide standard dosimetric figures such as percentage dose depth curves, two-dimensional dose distributions and 3D dose profiles at different positions both inside and outside the interaction chamber. The application was validated by comparing its predictions to experimental measurements carried out on a real laser-driven accelerator. The work is aimed at optimizing the source, by using this novel application, for radiobiological studies and, in perspective, for medical applications. - Highlights: • Development of a Monte Carlo application based on GEANT4 toolkit. • Experimental measurements carried out with a laser-driven acceleration system. • Validation of Geant4 application comparing experimental data with the simulated ones. • Dosimetric characterization of the acceleration system.

  13. Unsteady hydrodynamic forces acting on a robotic hand and its flow field.

    Science.gov (United States)

    Takagi, Hideki; Nakashima, Motomu; Ozaki, Takashi; Matsuuchi, Kazuo

    2013-07-26

    This study aims to clarify the mechanism of generating unsteady hydrodynamic forces acting on a hand during swimming in order to directly measure the forces, pressure distribution, and flow field around the hand by using a robotic arm and particle image velocimetry (PIV). The robotic arm consisted of the trunk, shoulder, upper arm, forearm, and hand, and it was independently computer controllable in five degrees of freedom. The elbow-joint angle of the robotic arm was fixed at 90°, and the arm was moved in semicircles around the shoulder joint in a plane perpendicular to the water surface. Two-component PIV was used for flow visualization around the hand. The data of the forces and pressure acting on the hand were sampled at 200Hz and stored on a PC. When the maximum resultant force acting on the hand was observed, a pair of counter-rotating vortices appeared on the dorsal surface of the hand. A vortex attached to the hand increased the flow velocity, which led to decreased surface pressure, increasing the hydrodynamic forces. This phenomenon is known as the unsteady mechanism of force generation. We found that the drag force was 72% greater and the lift force was 4.8 times greater than the values estimated under steady flow conditions. Therefore, it is presumable that swimmers receive the benefits of this unsteady hydrodynamic force.

  14. Nuclear physicist, arms control advocate

    CERN Multimedia

    Chang, K

    2002-01-01

    Victor F. Weisskopf, a nuclear physicist who worked on the Manhattan Project to build the first atomic bomb in World War II and later became an ardent advocate of arms control, died Monday at his home in Newton, MA, USA. He was 93 (1 page).

  15. Rhetorical Histories and Arms Negotiations.

    Science.gov (United States)

    Kane, Thomas

    1988-01-01

    Argues that the use of historical events as rhetorical artifacts has sustained cold war assumptions and attitudes; that rhetorical events provide composites for rhetorical histories which become the basis for argumentative appeals; and that these rhetorical histories continue to permeate American diplomacy in general and arms negotiations in…

  16. 中美战略文化差异性探究*--基于《中国武装力量的多样化运用》与《美国国防战略指针》的解读%A Study of the Strategic Cultural Differences between China and America Based on an Interpretation of The Diversified Employment of China's Armed Forces and of The U.S.Defense Strategic Guidance

    Institute of Scientific and Technical Information of China (English)

    王巍; 刘少华

    2014-01-01

    Strategic culture is the strategic thinking mode that national strategic decision makers have in the aspect of national security.The Diversified Employment ofChina's Armed Forces and U.S.Defense Strategic Guidance are different in the understanding of the strategic environment,in the view of international conflicts,and in the understanding of the effect of the force.It shows differences between cooperative strategic culture of China and offensive strategic culture of America.China should construct mature cooperative strategic culture,strengthen strategic interaction with the United States,and take advantage of the weaknesses and flaws of American strategic culture,to effectively reduce the strategic pressure of America,and to gain initiative in future Sino-US strategic gaming.%战略文化是国家战略决策者在国家安全事务方面的战略思维模式。《中国武装力量的多样化运用》与《美国国防战略指针》在战略环境的认识、国际冲突的看法、暴力效用的理解上均有明显不同,凸显了中国合作型战略文化与美国冲突型战略文化的差异。中国应通过建构成熟的合作型战略文化、加强与美国的战略互动、充分利用美国战略文化的弱点来有效地规避美国的战略压力,掌握未来中美战略博弈的主动权。

  17. Multiple Identifications in Multi-Armed Bandits

    CERN Document Server

    Bubeck, Sébastien; Viswanathan, Nitin

    2012-01-01

    We study the problem of identifying the top $m$ arms in a multi-armed bandit game. Our proposed solution relies on a new algorithm based on successive rejects of the seemingly bad arms, and successive accepts of the good ones. This algorithmic contribution allows to tackle other multiple identifications settings that were previously out of reach. In particular we show that this idea of successive accepts and rejects applies to the multi-bandit best arm identification problem.

  18. Note: A rigid piezo motor with large output force and an effective method to reduce sliding friction force

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Ying; Lu, Qingyou, E-mail: qxl@ustc.edu.cn [High Magnetic Field Laboratory, Chinese Academy of Sciences and University of Science and Technology of China, Hefei, Anhui 230026 (China); Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230026 (China); Hou, Yubin [High Magnetic Field Laboratory, Chinese Academy of Sciences and University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2014-05-15

    We present a completely practical TunaDrive piezo motor. It consists of a central piezo stack sandwiched by two arm piezo stacks and two leg piezo stacks, respectively, which is then sandwiched and spring-clamped by a pair of parallel polished sapphire rods. It works by alternatively fast expanding and contracting the arm/leg stacks while slowly expanding/contracting the central stack simultaneously. The key point is that sufficiently fast expanding and contracting a limb stack can make its two sliding friction forces well cancel, resulting in the total sliding friction force is <10% of the total static friction force, which can help increase output force greatly. The piezo motor's high compactness, precision, and output force make it perfect in building a high-quality harsh-condition (vibration resistant) atomic resolution scanning probe microscope.

  19. Nuclear arms race gearing for speedup

    International Nuclear Information System (INIS)

    To probe the rationale behind the big buildup in US strategic arms that is presaged by the current enhanced R and D effort - and to explore the broader, more long-term role of science and technology in the nuclear arms race - C and EN in recent months spoke with a host of experts both within and outside the defense establishment. It is a topic of incredible complexity, high controversy, and of the highest stakes imaginable - the survival of civilization. This buildup will include over the next decade, apart from the MX, a new, highly accurate, submarine-launched ballistic missile and a fleet of very large submarines to carry it; an air-launched cruise missile; a new long-range bomber; a new intermediate-range missile and a new ground-launched cruise missile, both capable of hitting targets in the Soviet Union from proposed bases in Western Europe; and a new sea-launched cruise missile that can be fired from conventional submarines or other naval vessels. To spokesmen for, and members of, the defense establishment the US buildup is prudent, even minimal. According to them, it is needed to keep the US at least on a par with the growth of Soviet strategic might which was very substantial in the 1970's and which will carry over into the 1980's with further major gains. It also is needed to keep the lid on Soviet expansionism; and it is the best way to prevent a nuclear war. To critics, the proposed buildup is the height of lunacy. According to them, the US strategic arsenal is more than adequate today. And it can continue to serve its only legitimate purpose - to deter nuclear war, no matter how much the Soviets may choose to build up their nuclear forces - with a much-more-modest modernization program

  20. Different strategy of hand choice after learning of constant and incremental dynamical perturbation in arm reaching

    Directory of Open Access Journals (Sweden)

    Chie eHabagishi

    2014-02-01

    Full Text Available In daily life, we encounter situations where we must quickly decide which hand to use for a motor action. Here, we investigated whether the hand chosen for a motor action varied over a short timescale (i.e., hours with changes in arm dynamics. Participants performed a reaching task in which they moved a specified hand to reach a target on a virtual reality display. During the task, a resistive viscous force field was abruptly applied to only the dominant hand. To evaluate changes in hand choice caused by this perturbation, participants performed an interleaved choice test in which they could freely choose either hand for reaching. Furthermore, to investigate the effect of temporal changes on arm dynamics and hand choice, we exposed the same participants to another condition in which the force field was introduced gradually. When the abrupt force was applied, use of the perturbed hand significantly decreased and not changed during the training. In contrast, when the incremental force was applied, use of the perturbed hand gradually decreased as force increased. Surprisingly, even though the final amount of force was identical between the two conditions, hand choice was significantly biased toward the unperturbed hand in the gradual condition. These results suggest that time-varying changes in arm dynamics may have a greater influence on hand choice than the amplitude of the resistant force itself.