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Sample records for arm based soc

  1. Co-verification of hardware and software for ARM SoC design

    CERN Document Server

    Andrews, Jason

    2004-01-01

    Hardware/software co-verification is how to make sure that embedded system software works correctly with the hardware, and that the hardware has been properly designed to run the software successfully -before large sums are spent on prototypes or manufacturing. This is the first book to apply this verification technique to the rapidly growing field of embedded systems-on-a-chip(SoC). As traditional embedded system design evolves into single-chip design, embedded engineers must be armed with the necessary information to make educated decisions about which tools and methodology to deploy. SoC verification requires a mix of expertise from the disciplines of microprocessor and computer architecture, logic design and simulation, and C and Assembly language embedded software. Until now, the relevant information on how it all fits together has not been available. Andrews, a recognized expert, provides in-depth information about how co-verification really works, how to be successful using it, and pitfalls to avoid. H...

  2. AMBA Based Advanced DMA Controller for SoC

    Directory of Open Access Journals (Sweden)

    Abdullah Aljumah

    2016-03-01

    Full Text Available this paper describes the implementation of an AMBA Based Advanced DMA Controller for SoC. It uses AMBA Specifications, where two buses AHB and APB are defined and works for processor as system bus and peripheral bus respectively. The DMA controller functions between these two buses as a bridge and allow them to work concurrently. Depending on the speed of peripherals it uses buffering mechanism. Therefore an asynchronous FIFO is used for synchronizing the speed of peripherals. The proposed DMA controller can works in SoC along with processor and achieve fast data rate. The method introduced significant volume of data transfer with very low timing characteristics. Thus it is a better choice in respect of timing and volume of data. These two issues have been resolved under this research study. The results are compared with the AMD processors, like Geode GX 466, GX 500 and GX 533, and the presence and absence of DMA controller with processor is discussed and compared. The DMAC stands to be better alternative in SoC design.

  3. FPGA Based SOC for Railway Level crossing Management System

    OpenAIRE

    Ramachandran, R.; J. Thomas Joseph Prakash

    2012-01-01

    It is to develop the FPGA based, System on Chip (SOC) to implement the safety system in Railways for level crossing. For the communication RF module[1] with the coverage of large distance, that is Outdoor line-of-sight: up to 15 miles (24 km) with high gain antenna is used. RF Transceiver has many salient features[2], such as, Advanced Networking & Security, True peer-to-peer (no "master" required) communications, Point-to-point & point-to-multipoint topologies supported, Continuous RF data s...

  4. The ZYNQ book embedded processing with the ARM Cortex-A9 on the Xilinx Zynq-7000 all programmable SoC

    CERN Document Server

    Crockett, Louise H; Enderwitz, Martin A; Stewart, Robert W

    2014-01-01

    This book is about the Zynq-7000 All Programmable System on Chip, the family of devices from Xilinx that combines an application-grade ARM Cortex-A9 processor with traditional FPGA logic fabric. Catering for both new and experienced readers, it covers fundamental issues in an accessible way, starting with a clear overview of the device architecture, and an introduction to the design tools and processes for developing a Zynq SoC. Later chapters progress to more advanced topics such as embedded systems development, IP block design and operating systems. Maintaining a 'real-world' perspective, the book also compares Zynq with other device alternatives, and considers end-user applications. The Zynq Book is accompanied by a set of practical tutorials hosted on a companion website. These tutorials will guide the reader through first steps with Zynq, following on to a complete, audio-based embedded systems design.

  5. Research on SOC estimation based on second-order RC model

    Directory of Open Access Journals (Sweden)

    Xieyang Wang

    2012-11-01

    Full Text Available The estimation accuracy of batteries’ State of Charge (SOC plays an important role in the development of hybrid electric vehicle (HEV. Accurate estimation of SOC can prevent battery from overly charging and discharging, so the lifetime of batteries will be increased. Although Kalman filter algorithm has better estimation accuracy for HEV application in which the current changes fast, Kalman filter algorithm deeply relies on the battery model. In other words, the accuracy of batteries’ SOC estimation needs precise batteries models. Besides, when the HEV is running, the statistical characteristics of noise produced in the course of the battery management system collecting data are unknown. This can cause estimated performance of Kalman filter algorithm to decrease even diffuse. To solve the problem, adaptive Kalman filter algorithm is adopted to estimate battery SOC based on the second order RC battery model in this paper. Through MATLAB simulation analysis, the estimation accuracy of battery SOC is improved to some extent.

  6. SOC EKF Estimation based on a Second-order LiFePO4 Battery Model

    Directory of Open Access Journals (Sweden)

    Zheng Zhu

    2013-08-01

    Full Text Available An accurate battery State of Charge (SOC estimation has great significance in improving battery life and vehicle performance. An improved second-order battery model is proposed in this paper through quantities of LiFePO4 battery experiments. The parameters of the model were acquired by the HPPC composite pulse condition under different temperature, charging and discharging rates, SOC. Based on the model, battery SOC is estimated by Extended Kalman Filter (EKF. Comparison of three different pulse conditions shows that the average error of SOC estimation of this algorithm is about 4.2%. The improved model is able to reflect the dynamic performance of batteries suitably, and the SOC estimation algorithm is provided with higher accuracy and better dynamic adaptability.

  7. SOC Estimation of LiFePO4 Battery based on Improved Ah Integral Method

    Directory of Open Access Journals (Sweden)

    Zheng ZHU

    2013-07-01

    Full Text Available State of charge (SOC is the most important status parameters of energy storage system, which is able to predict the available mileage of electric vehicle. In fact, the accuracy of SOC estimation plays a vital role in the usability and security of the battery. To fully consider the practical demands, a novel method to predict SOC of LiFePO4 battery is presented in this paper, which defines the correct coefficient separately under two working conditions of charging and discharging. Based on effective factors such as coulombic efficiency, charge and discharge current, and temperature, an Ah integral SOC estimation method with two kinds of efficiency correct coefficients is established by performing massive experimental study. Experiments prove that the estimated error of SOC is less than 5%. Compared with the original Ah method, the improved Ah method is more advantageous in the accuracy and reliability.

  8. Optimal hardware/software co-synthesis for core-based SoC designs

    Institute of Scientific and Technical Information of China (English)

    Zhan Jinyu; Xiong Guangze

    2006-01-01

    A hardware/software co-synthesis method is presented for SoC designs consisting of both hardware IP cores and software components on a graph-theoretic formulation. Given a SoC integrated with a set of functions and a set of performance factors, a core for each function is selected from a set of alternative IP cores and software components, and optimal partitions is found in a way to evenly balance the performance factors and to ultimately reduce the overall cost, size, power consumption and runtime of the core-based SoC. The algorithm formulates IP cores and components into the corresponding mathematical models, presents a graph-theoretic model for finding the optimal partitions of SoC design and transforms SoC hardware/software co-synthesis problem into finding optimal paths in a weighted, directed graph. Overcoming the three main deficiencies of the traditional methods, this method can work automatically, evaluate more performance factors at the same time and meet the particularity of SoC designs.At last, the approach is illustrated that is practical and effective through partitioning a practical system.

  9. SOC 312

    OpenAIRE

    coursehomework.com

    2015-01-01

    SOC 312 ENTIRE CLASS To purchase this visit following link: https://coursehomework.com/product/soc-312-entire-class/   Contact us at: SOC 312 ENTIRE CLASS   SOC 312 Entire Class   SOC 312 Week 1 DQ 1 Bronfenbrenner’s Ecological Model  Your text uses Bronfenbrenner’s ecological model to explain how children’s development is affected by different groups within their world. Using this theory, we...

  10. Design of SOC based on IP core%基于IP的系统芯片(SOC)设计

    Institute of Scientific and Technical Information of China (English)

    薛严冰; 徐晓轩

    2004-01-01

    随着集成电路设计与工艺技术水平的提高,出现了系统芯片(SOC)的概念.本文介绍了基于IP的SOC设计方式的设计流程,指出了其与传统IC设计方法的不同.讨论了支持SOC设计的几种关键技术,并对SOC的技术优势及发展趋势作了全面阐述.

  11. A Prototype-Based Gate-Level Cycle-Accurate Methodology for SoC Performance Exploration and Estimation

    Directory of Open Access Journals (Sweden)

    Ching-Lung Su

    2013-01-01

    Full Text Available A prototype-based SoC performance estimation methodology was proposed for consumer electronics design. Traditionally, prototypes are usually used in system verification before SoC tapeout, which is without accurate SoC performance exploration and estimation. This paper attempted to carefully model the SoC prototype as a performance estimator and explore the environment of SoC performance. The prototype met the gate-level cycle-accurate requirement, which covered the effect of embedded processor, on-chip bus structure, IP design, embedded OS, GUI systems, and application programs. The prototype configuration, chip post-layout simulation result, and the measured parameters of SoC prototypes were merged to model a target SoC design. The system performance was examined according to the proposed estimation models, the profiling result of the application programs ported on prototypes, and the timing parameters from the post-layout simulation of the target SoC. The experimental result showed that the proposed method was accompanied with only an average of 2.08% of error for an MPEG-4 decoder SoC at simple profile level 2 specifications.

  12. Design of visual prosthesis image processing system based on SoC

    Science.gov (United States)

    Guo, Fei; Yang, Yuan; Gao, Yong; Wu, Chuan Ke

    2014-07-01

    This paper presents a visual prosthesis image processing system based on Leon3 SoC (System on Chip) platform. The system is built through GRLIB system development platform. It integrates the image preprocessing IP core, image encoder IP core and image data modulation IP core we designed. We transplant the system to the FPGA development board and verify the system functions. The results show that the designed system can achieve the functions of visual prosthesis image processing system effectively.

  13. Surviving the SOC revolution a guide to platform-based design

    CERN Document Server

    Chang, Henry; Hunt, Merrill; Martin, Grant; McNelly, Andrew; Todd, Lee

    2007-01-01

    `This book crystallizes what may become a defining moment in the electronics industry - the shift to platform-based design. It provides the first comprehensive guidebook for those who will build, and use, the integration platforms that may soon drive the system-on-chip revolution. ' Richard Goering - Senior Technology Editor, Electronic Engineering Times `""Surviving the SOC Revolution"" takes the ""Reuse Methodology Manual"" top the next plateau - the `platform'. It goes beyond codifying best design practices for an `IP black', enabling true Virtual Componenets. Platform-based d

  14. SOC Based Battery Cell Balancing with a Novel Topology and Reduced Component Count

    Directory of Open Access Journals (Sweden)

    Zheng Chen

    2013-05-01

    Full Text Available This paper proposes a novel battery cell balancing topology with reduced component count and simplified control. The balancing algorithm is based on the state of charge (SOC of each individual cell instead of cell voltage. The principle of the proposed topology is analyzed and verified through simulation and experiments. Then an experimental battery test workbench is established to validate the proposed balancing algorithm. The experimental results show that the proposed balancing topology and associated algorithm can perform well in real applications.

  15. Soc 262 courses / soc262homeworkdotcom

    OpenAIRE

    Soc 262

    2015-01-01

    FOR MORE CLASSES VISIT www.soc262homework.com SOC 262 Week 1 Assignment Racial and Ethnic Groups Matrix SOC 262 Week 2 Assignment: Racial and Ethnic Groups Matrix SOC 262 Week 3 Assignment Racism Presentation SOC 262 Week 4 Assignment New in America paper SOC 262 Week 5 Assignment Media and Race SOC 262 Week 5 Assignment Racial and Ethnic Relations Matrix Paper and Presentation  

  16. Multiple MIPS 4Kc cores based interrupt controller design and its implementation on HDTV SoC platform

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform,especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property (IP), the interrupt controller has reusability and expandability with the layered structure.

  17. An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl;

    2005-01-01

    The demand for IP reuse and system level scalability in System-on-Chip (SoC) designs is growing. Network-onchip (NoC) constitutes a viable solution space to emerging SoC design challenges. In this paper we describe an OCP compliant network adapter (NA) architecture for the MANGO NoC. The NA...... decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0.......13 um CMOS standard cell instantiations of the architecture....

  18. Research on SOC estimation based on second-order RC model

    OpenAIRE

    Xieyang Wang; Quan Cao; Qing Xiao; Lunan Liu; Tiezhou Wu

    2012-01-01

    The estimation accuracy of batteries’ State of Charge (SOC) plays an important role in the development of hybrid electric vehicle (HEV). Accurate estimation of SOC can prevent battery from overly charging and discharging, so the lifetime of batteries will be increased. Although Kalman filter algorithm has better estimation accuracy for HEV application in which the current changes fast, Kalman filter algorithm deeply relies on the battery model. In other words, the accuracy of batteries’ SO...

  19. The inventory-based approach for prediction of SOC change following land use change

    Directory of Open Access Journals (Sweden)

    van Wesemael B.

    2004-01-01

    Full Text Available This paper describes and illustrates an approach to predict soil organic carbon (SOC change in time after land use change as derived from SOC differences in space. The approach requires the availability of a SOC inventory for spatially explicit combinations of soil and land use type, further termed landscape units (LSU. SOC of LSU with equal soil type but different land use type are compared and the observed differences in SOC are interpreted as the expected SOC change after the corresponding land use change. From a confrontation with time series of agro-statistical data on crop and grassland areas and on animal manure production, we conclude that the approach is a low-cost alternative for more complex methods like multitemporal assessments and modelling, provided that (i an inventory reflecting current management and climate conditions and (ii additional information on the extent and type of recent land use changes are available. Examples of land use and land management changes are discussed, such as grassland – cropland conversions, the conversion of permanent to temporary grassland, or changes in manure application.

  20. Comparison Study on Two Model-Based Adaptive Algorithms for SOC Estimation of Lithium-Ion Batteries in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Yong Tian

    2014-12-01

    Full Text Available State of charge (SOC estimation is essential to battery management systems in electric vehicles (EVs to ensure the safe operations of batteries and providing drivers with the remaining range of the EVs. A number of estimation algorithms have been developed to get an accurate SOC value because the SOC cannot be directly measured with sensors and is closely related to various factors, such as ambient temperature, current rate and battery aging. In this paper, two model-based adaptive algorithms, including the adaptive unscented Kalman filter (AUKF and adaptive slide mode observer (ASMO are applied and compared in terms of convergence behavior, tracking accuracy, computational cost and estimation robustness against parameter uncertainties of the battery model in SOC estimation. Two typical driving cycles, including the Dynamic Stress Test (DST and New European Driving Cycle (NEDC are applied to evaluate the performance of the two algorithms. Comparison results show that the AUKF has merits in convergence ability and tracking accuracy with an accurate battery model, while the ASMO has lower computational cost and better estimation robustness against parameter uncertainties of the battery model.

  1. Generic System Verilog Universal Verification Methodology Based Reusable Verification Environment for Efficient Verification of Image Signal Processing IPS/SOCS

    Directory of Open Access Journals (Sweden)

    Abhishek Jain

    2013-01-01

    Full Text Available In this paper, we present Generic System Verilog Universal Verification Methodology based ReusableVerification Environment for efficient verification of Image Signal Processing IP’s/SoC’s. With the tightschedules on all projects it is important to have a strong verification methodology which contributes toFirst Silicon Success. Deploy methodologies which enforce full functional coverage and verification ofcorner cases through pseudo random test scenarios is required. Also, standardization of verification flow isneeded. Previously, inside imaging group of ST, Specman (e/Verilog based Verification Environment forIP/Subsystem level verification and C/C++/Verilog based Directed Verification Environment for SoC LevelVerification was used for Functional Verification. Different Verification Environments were used at IPlevel and SoC level. Different Verification/Validation Methodologies were used for SoC Verification acrossmultiple sites. Verification teams were also looking for the ways how to catch bugs early in the designcycle? Thus, Generic System Verilog Universal Verification Methodology (UVM based ReusableVerification Environment is required to avoid the problem of having so many methodologies and provides astandard unified solution which compiles on all tools.

  2. Generic System Verilog Universal Verification Methodology Based Reusable Verification Environment for Efficient Verification of Image Signal Processing IPS/SOCS

    Directory of Open Access Journals (Sweden)

    Abhishek Jain

    2012-12-01

    Full Text Available In this paper, we present Generic System Verilog Universal Verification Methodology based Reusable Verification Environment for efficient verification of Image Signal Processing IP’s/SoC’s. With the tight schedules on all projects it is important to have a strong verification methodology which contributes to First Silicon Success. Deploy methodologies which enforce full functional coverage and verification of corner cases through pseudo random test scenarios is required. Also, standardization of verification flow is needed. Previously, inside imaging group of ST, Specman (e/Verilog based Verification Environment forIP/Subsystem level verification and C/C++/Verilog based Directed Verification Environment for SoC Level Verification was used for Functional Verification. Different Verification Environments were used at IP level and SoC level. Different Verification/Validation Methodologies were used for SoC Verification across multiple sites. Verification teams were also looking for the ways how to catch bugs early in the design cycle? Thus, Generic System Verilog Universal Verification Methodology (UVM based Reusable Verification Environment is required to avoid the problem of having so many methodologies and provides a standard unified solution which compiles on all tools.

  3. Highly monodisperse M III-based soc -MOFs (M = in and Ga) with cubic and truncated cubic morphologies

    KAUST Repository

    Pang, Maolin

    2012-08-15

    In this work, we carry out an investigation on shape-controlled growth of In III- and Ga III-based square-octahedral metal-organic frameworks (soc-MOFs). In particular, controllable crystal morphological evolution from simple cubes to complex octadecahedra has been achieved, and resultant highly uniform crystal building blocks promise new research opportunities for preparation of self-assembled MOF materials and related applications. © 2012 American Chemical Society.

  4. The Design of Humanoid Robot Arm Based on Morphological and Neurological Analysis of Human Arm

    OpenAIRE

    Moon, Yongseon; Ko, Nak Yong; Bae, Youngchul

    2009-01-01

    In this paper, we have presented the implementation and performance evaluation for SERCOS based humanoid robot arm by using morphological and neurological analysis of human arm. Moreover, we reviewed the possibility of application of these robot arms. First, we proposed robot development methodology of open architecture based on ISO15745 for "opening of humanoid robot." Then, we verified the method of implementation of humanoid robot arm and its application to the real world. We have implemen...

  5. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

    KAUST Repository

    Alezi, Dalal

    2015-09-28

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

  6. Partial reconfiguration of a peripheral in an FPGA-based SoC to analyse performance-area behaviour

    Science.gov (United States)

    Cardona, Andres; Guo, Yi; Ferrer, Carles

    2011-05-01

    Systems on Chip (SoC) are present in a wide range of applications. This diversity in addition with the quantity of critical variables involved in their design process becomes it as a great challenging topic. FPGAs have consolidated as a preferred device to develop and prototype SoCs, and consequently Partial Reconfiguration (PR) has gained importance in this approach. Through PR it is possible to have a section of the FPGA operating, while other section is disabled and partially reconfigured to provide new functionality. In this way hardware resources can be time-multiplexed and therefore it is possible to reduce size, cost and power. In this case we focus on the implementation of a SoC, in an FPGA-based board, with one of its peripherals being a reconfigurable partition (RP). Inside this RP different hardware modules defined as reconfigurable modules (RM) can be configured. Thus, the system is suitable to have different hardware configurations depending on the application needs and FPGA limitations, while the rest of the system continues working. To this end a MicroBlaze soft-core processor is used in the system design and a Virtex-5 FPGA board is utilized to its implementations. A remote sensing application is used to explore the capabilities of this approach. Identifying the section(s) of the application suitable of being time-shared it is possible to define the RMs to place inside the RP. Different configurations were carried out and measurements of area were taken. Preliminary results of the performance-area utilisation are presented to validate the improvement in flexibility and resource usage.

  7. SOCS, inflammation and autoimmunity

    Directory of Open Access Journals (Sweden)

    Akihiko eYoshimura

    2012-03-01

    Full Text Available Cytokines play essential roles in innate and adaptive immunity. However, excess cytokines or dysregulation of cytokine signaling can cause a variety of diseases, including allergies, autoimmune diseases, inflammation, and cancer. Most cytokines utilize the so-called Janus kinase-signal transducers and activators of transcription (JAK-STAT pathway. This pathway is negatively regulated by various mechanisms including suppressors of cytokine signaling (SOCS proteins. SOCS proteins bind to JAK or cytokine receptors, thereby suppressing further signaling events. Especially, SOCS1 and SOCS3 are strong inhibitors of JAK, because these two contain kinase inhibitory region (KIR at the N-terminus. Studies using conditional knockout mice have shown that SOCS proteins are key physiological as well as pathological regulators of immune homeostasis. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of helper T cell differentiation and functions.

  8. SOC 402 courses/snaptutorial

    OpenAIRE

    Amin Maalouf

    2015-01-01

    For more classes visit www.snaptutorial.com   SOC 402 Week 1 DQ 1 Three Sociological Perspectives SOC 402 Week 1 DQ 2 Qualitative vs. Quantitative Research & the Methods of Social Research SOC 402 Week 2 DQ 1 McDonaldization SOC 402 Week 2 DQ 2 Generational Differences in the Workplace SOC 402 Week 2 Assignment Women and Flexibility in the Workplace SOC 402 Week 3 DQ 1 Retirement SOC 402 Week 3 DQ 2 Sexual Harassment SOC 402 Week 3 Assignment O...

  9. A software radio platform based on ARM and FPGA

    Directory of Open Access Journals (Sweden)

    Yang Xin.

    2016-01-01

    Full Text Available The rapid rise in computational performance offered by computer systems has greatly increased the number of practical software radio applications. A scheme presented in this paper is a software radio platform based on ARM and FPGA. FPGA works as the coprocessor together with the ARM, which serves as the core processor. ARM is used for digital signal processing and real-time data transmission, and FPGA is used for synchronous timing control and serial-parallel conversion. A SPI driver for real-time data transmission between ARM and FPGA under ARM-Linux system is provided. By adopting modular design, the software radio platform is capable of implementing wireless communication functions and satisfies the requirements of real-time signal processing platform for high security and broad applicability.

  10. SOC REJECTION BY NANOFILTRATION

    Science.gov (United States)

    A study was conducted to evaluate the rejection of six synthetic organic compounds (SOCs) from a potable water source by a nanofiltration membrane process. The S0Cs were ethylene dibromide (EDB), dibromochloropropane (DBCP), chlordane, heptachlor, methoxychlor and alachlor. To in...

  11. Armes

    OpenAIRE

    Camps, G.; Chenorkian, R.; Lhote, H.

    2013-01-01

    Préhistoire (G. Camps) Les armes des Paléoberbères de la Préhistoire ne présentent guère d’originalité mais à la documentation archéologique provenant de fouilles s’ajoute, en Afrique du Nord et au Sahara, une documentation iconographique d’une grande richesse que ne possèdent pas les autres pays riverains du bassin occidental de la Méditerranée. Durant les temps paléolithiques, les hommes qui occupèrent le Maghreb et le Sahara utilisèrent, en plus des outils et armes connus ailleurs ; biface...

  12. Bluetooth Based Home Automation and Security System Using ARM9

    Directory of Open Access Journals (Sweden)

    D.NARESH1 , B.CHAKRADHAR2 , S.KRISHNAVENI

    2013-09-01

    Full Text Available Today we are living in 21st century where automation is playing important role in human life. Home automation allows us to control household appliances like light, door, fan, AC etc. It also provides home security and emergency system to be activated. Home automation not only refers to reduce human efforts but also energy saving and time efficiency. The main objective of home automation and security is to help handicapped and old aged people who will enable them to control home appliances and alert them in critical situations. This paper put forwards the design of home automation and security system using ARM7 LPC2148 board. The design is based on a standalone embedded system board ARM7 LPC2148 at home. Home appliances are connected to the ARM7 and communication is established between the ARM7 and ARM9 with Bluetooth device. The home appliances are connected to the input / output ports of the embedded system board and their status is passed to the ARM7. We would develop an authentication to the system for authorized person to access home appliances. The device with low cost and scalable to less modification to the core is much important. It presents the design and implementation of automation system that can monitor and control home appliances via ARM9 S3C2440A board.

  13. Bailleul-le-Soc

    OpenAIRE

    Billand, Ghislaine

    2013-01-01

    Identifiant de l'opération archéologique : 9154 Date de l'opération : 2007 (EX) Le projet d’un parc éolien réparti sur les communes de Bailleul-le-Soc, Épineuse et Fouilleuse a entraîné la prescription d’une campagne de diagnostic archéologique sur quatre des neuf éoliennes. La présence de sites gallo-romains repérés par prospection aérienne à Épineuse « Le Haut du Bois Robin » et Bailleul-le-Soc « La Terre d’Éloge », laissait entrevoir la possibilité de documenter ces vestiges. L’interventi...

  14. ARM 7 BASED MP3 PLAYER

    Directory of Open Access Journals (Sweden)

    Ashiq V Mehta

    2014-02-01

    Full Text Available MP3 is a patented encoding format for digital audio which uses a form of lossy data compression. It is a common audio format for consumer audio streaming or storage, as well as a de facto standard of digital audio compression for the transfer and playback of music on most digital audio players. Since the MPEG-1 Layer III encoding technology is nowadays widely used it might be interesting to gain knowledge of how this powerful compression/decompression scheme actually functions. The MPEG-1 Layer III is capable of reducing the bit rate with a factor of 12 without almost any audible degradation. Arm7 lpc2148 is arm7tdmi-s core board microcontroller that uses 16/32-bit 64 pin (lqfp microcontroller no.lpc2148 from Philips (nxp.The hardware system of lpc2148 includes the necessary devices within only one mcu has such as usb, adc, dac, timer/counter, pwm, capture, i2c, spi, uart, and etc.

  15. Research on object-oriented SOC design methodology

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The growing complexity of System on Chip (SOC) requires a system level specification and design approach. High-level languages such as C+ +/SystemC can play multiple roles in system design as target languages. There are many practical problems in the application of object-oriented methods for this goal. Based on the analysis of traditional and system-level design methodology, a new object-oriented SOC design methodology with object-oriented design patterns is proposed, which emphasizes high-level design and verification. Aiming at the final goal of developing design patterns specific to SOC design, the reuse of design patterns in SOC systems and the capability of new SOC design patterns are discussed. With the illustration of some concrete examples of SOC design patterns, the application of object-oriented design methodology in the SOC design process is presented.

  16. Asynchronous Complex Pipeline Design Based on ARM Instruction Set

    Institute of Scientific and Technical Information of China (English)

    WANG Bing; WANG Qin; PENG Rui-hua; FU Yu-zhuo

    2008-01-01

    This paper proposes an asynchronous complex pipeline based on ARM-V3 instruction set. Muller pipeline structure is used as prototype, and the factors which may affect pipeline performance are analyzed. To balance the difficulty of asynchronous design and performance analysis, both complete asynchronous and partial asynchronous structures aere designed and compared. Results of comparison with the well-Rnown industrial product ARM922T verify that about 30% and 40% performance improvement of the partial and complete asynchronous complex pipelines can be obtained respectively. The design methodologies can also be used in the design of other asynchronous pipelines.

  17. Gesture Recognition Based on the Probability Distribution of Arm Trajectories

    Science.gov (United States)

    Wan, Khairunizam; Sawada, Hideyuki

    The use of human motions for the interaction between humans and computers is becoming an attractive alternative to verbal media, especially through the visual interpretation of the human body motion. In particular, hand gestures are used as non-verbal media for the humans to communicate with machines that pertain to the use of the human gestures to interact with them. This paper introduces a 3D motion measurement of the human upper body for the purpose of the gesture recognition, which is based on the probability distribution of arm trajectories. In this study, by examining the characteristics of the arm trajectories given by a signer, motion features are selected and classified by using a fuzzy technique. Experimental results show that the use of the features extracted from arm trajectories effectively works on the recognition of dynamic gestures of a human, and gives a good performance to classify various gesture patterns.

  18. A Parallax-based Distance Estimator for Spiral Arm Sources

    CERN Document Server

    Reid, M J; Menten, K M; Brunthaler, A

    2016-01-01

    The spiral arms of the Milky Way are being accurately located for the first time via trigonometric parallaxes of massive star forming regions with the BeSSeL Survey, using the Very Long Baseline Array and the European VLBI Network, and with the Japanese VERA project. Here we describe a computer program that leverages these results to significantly improve the accuracy and reliability of distance estimates to other sources that are known to follow spiral structure. Using a Bayesian approach, sources are assigned to arms based on their (l,b,v) coordinates with respect to arm signatures seen in CO and HI surveys. A source's kinematic distance, displacement from the plane, and proximity to individual parallax sources are also considered in generating a full distance probability density function. Using this program to estimate distances to large numbers of star forming regions, we generate a realistic visualization of the Milky Way's spiral structure as seen from the northern hemisphere.

  19. SOC 203 ASH Tutorial course/ Uoptutorial

    OpenAIRE

    Michael Crichton

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 Week 4 DQ 1 Gay Parenting SOC 203 Week 4 DQ 2 Reinvent...

  20. Autonomous sensor-based dual-arm satellite grappling

    Science.gov (United States)

    Wilcox, Brian; Tso, Kam; Litwin, Todd; Hayati, Samad; Bon, Bruce

    1989-01-01

    Dual-arm satellite grappling involves the integration of technologies developed in the Sensing and Perception (S&P) Subsystem for object acquisition and tracking, and the Manipulator Control and Mechanization (MCM) Subsystem for dual-arm control. S&P acquires and tracks the position, orientation, velocity, and angular velocity of a slowly spinning satellite, and sends tracking data to the MCM subsystem. MCM grapples the satellite and brings it to rest, controlling the arms so that no excessive forces or torques are exerted on the satellite or arms. A 350-pound satellite mockup which can spin freely on a gimbal for several minutes, closely simulating the dynamics of a real satellite is demonstrated. The satellite mockup is fitted with a panel under which may be mounted various elements such as line replacement modules and electrical connectors that will be used to demonstrate servicing tasks once the satellite is docked. The subsystems are housed in three MicroVAX II microcomputers. The hardware of the S&P Subsystem includes CCD cameras, video digitizers, frame buffers, IMFEX (a custom pipelined video processor), a time-code generator with millisecond precision, and a MicroVAX II computer. Its software is written in Pascal and is based on a locally written vision software library. The hardware of the MCM Subsystem includes PUMA 560 robot arms, Lord force/torque sensors, two MicroVAX II computers, and unimation pneumatic parallel grippers. Its software is written in C, and is based on a robot language called RCCL. The two subsystems are described and test results on the grappling of the satellite mockup with rotational rates of up to 2 rpm are provided.

  1. Photoelectric radar servo control system based on ARM+FPGA

    Science.gov (United States)

    Wu, Kaixuan; Zhang, Yue; Li, Yeqiu; Dai, Qin; Yao, Jun

    2016-01-01

    In order to get smaller, faster, and more responsive requirements of the photoelectric radar servo control system. We propose a set of core ARM + FPGA architecture servo controller. Parallel processing capability of FPGA to be used for the encoder feedback data, PWM carrier modulation, A, B code decoding processing and so on; Utilizing the advantage of imaging design in ARM Embedded systems achieves high-speed implementation of the PID algorithm. After the actual experiment, the closed-loop speed of response of the system cycles up to 2000 times/s, in the case of excellent precision turntable shaft, using a PID algorithm to achieve the servo position control with the accuracy of + -1 encoder input code. Firstly, This article carry on in-depth study of the embedded servo control system hardware to determine the ARM and FPGA chip as the main chip with systems based on a pre-measured target required to achieve performance requirements, this article based on ARM chip used Samsung S3C2440 chip of ARM7 architecture , the FPGA chip is chosen xilinx's XC3S400 . ARM and FPGA communicate by using SPI bus, the advantage of using SPI bus is saving a lot of pins for easy system upgrades required thereafter. The system gets the speed datas through the photoelectric-encoder that transports the datas to the FPGA, Then the system transmits the datas through the FPGA to ARM, transforms speed datas into the corresponding position and velocity data in a timely manner, prepares the corresponding PWM wave to control motor rotation by making comparison between the position data and the velocity data setted in advance . According to the system requirements to draw the schematics of the photoelectric radar servo control system and PCB board to produce specially. Secondly, using PID algorithm to control the servo system, the datas of speed obtained from photoelectric-encoder is calculated position data and speed data via high-speed digital PID algorithm and coordinate models. Finally, a

  2. SOC 315 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    emilyjessi

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   ASHFORD SOC 315 Week 1 Individual Assignment Cultural Background Summary ASHFORD SOC 315 Week 1 DQ 1 ASHFORD SOC 315 Week 1 DQ 2 ASHFORD SOC 315 Week 2 Individual Assignment Ethnocentrism Matrix ASHFORD SOC 315 Week 2 Individual Assignment Media Reaction Paper ASHFORD SOC 315 Week 2 DQ 1 and DQ 2 ASHFORD SOC 315 Week 3 Individual Assignment Intercultural Commu...

  3. Desarrollo de aplicaciones basadas en Linux Embedded en una arquitectura basada en Cyclone V SoC (System on Chip) de Altera

    OpenAIRE

    Rodríguez Díaz-Delgado, Marcos

    2014-01-01

    We attempt to integrate and start up the set of necessary tools to deploy the design cycle of embedded systems based on Embedded Linux on a "Cyclone V SoC" made by Altera. First, we will analyze the available tools for designing the hardware system of the SoCkit development kit, made by Arrow, which has a "Cyclone V SoC" system (based on a "ARM Cortex-A9 MP Core" architecture). When designing the SoCkit board hardware, we will create a new peripheral to integrate it into the hardware syste...

  4. The Study of Target Tracking Based on ARM Embedded Platform

    Directory of Open Access Journals (Sweden)

    Xiaoming Liu

    2012-08-01

    Full Text Available This article explored a solution of target tracking based on the ARM embedded platform, which gave a design and realization of removable image processing equipment to detect and track the pedestrian in the video. The integration level of embedded platform is very high, embedded platform supports real-time multitasking operating system, and comply with the requirements of real-time and miniaturization. Studying how to combine embedded platform with target tracking, it has instructional significance for robot development applications.

  5. SOC 203 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    graceruby

    2015-01-01

    For more course tutorials visit   www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 We...

  6. Structural Optimization of Slender Robot Arm Based on Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2012-01-01

    Full Text Available An effective structural optimization method based on a sensitivity analysis is proposed to optimize the variable section of a slender robot arm. The structure mechanism and the operating principle of a polishing robot are introduced firstly, and its stiffness model is established. Then, a design of sensitivity analysis method and a sequential linear programming (SLP strategy are developed. At the beginning of the optimization, the design sensitivity analysis method is applied to select the sensitive design variables which can make the optimized results more efficient and accurate. In addition, it can also be used to determine the scale of moving step which will improve the convergency during the optimization process. The design sensitivities are calculated using the finite difference method. The search for the final optimal structure is performed using the SLP method. Simulation results show that the proposed structure optimization method is effective in enhancing the stiffness of the robot arm regardless of the robot arm suffering either a constant force or variable forces.

  7. A Parallax-based Distance Estimator for Spiral Arm Sources

    Science.gov (United States)

    Reid, M. J.; Dame, T. M.; Menten, K. M.; Brunthaler, A.

    2016-06-01

    The spiral arms of the Milky Way are being accurately located for the first time via trigonometric parallaxes of massive star-forming regions with the Bar and Spiral Structure Legacy Survey, using the Very Long Baseline Array and the European VLBI Network, and with the Japanese VLBI Exploration of Radio Astrometry project. Here we describe a computer program that leverages these results to significantly improve the accuracy and reliability of distance estimates to other sources that are known to follow spiral structure. Using a Bayesian approach, sources are assigned to arms based on their (l, b, v) coordinates with respect to arm signatures seen in CO and H i surveys. A source's kinematic distance, displacement from the plane, and proximity to individual parallax sources are also considered in generating a full distance probability density function. Using this program to estimate distances to large numbers of star-forming regions, we generate a realistic visualization of the Milky Way's spiral structure as seen from the northern hemisphere.

  8. SOC 262 UOP Course Tutorial/Tutorialrank

    OpenAIRE

    jessicaoli

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 4 Times, Rating: A+   SOC 262 Week 1 Assignment Racial and Ethnic Groups Matrix SOC 262 Week 2 Assignment: Racial and Ethnic Groups Matrix SOC 262 Week 3 Assignment Racism Presentation SOC 262 Week 4 Assignment New in America paper SOC 262 Week 5 Assignment Media and Race SOC 262 Week 5 Assignment Racial and Ethnic Relations Matrix Paper and Presentation    

  9. SOC 262 UOP Tutorial course/ Uoptutorial

    OpenAIRE

    Michael Crichton

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   SOC 262 Week 1 Assignment Racial and Ethnic Groups Matrix SOC 262 Week 2 Assignment: Racial and Ethnic Groups Matrix SOC 262 Week 3 Assignment Racism Presentation SOC 262 Week 4 Assignment New in America paper SOC 262 Week 5 Assignment Media and Race SOC 262 Week 5 Assignment Racial and Ethnic Relations Matrix Paper and Presentation    

  10. SOC 402 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    lucylily

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A   ASHFORD SOC 402 Week 1 DQ 1 Three Sociological Perspectives ASHFORD SOC 402 Week 1 DQ 2 Qualitative vs. Quantitative Research & the Methods of Social Research ASHFORD SOC 402 Week 2 DQ 1 McDonaldization ASHFORD SOC 402 Week 2 DQ 2 Generational Differences in the Workplace ASHFORD SOC 402 Week 2 Assignment Women and Flexibility in the Workplace ASHFORD SOC 402 ...

  11. Design and Implementation of Submicron Level 10T Full Adder in ALU Using Cell Based and SOC Technology

    Directory of Open Access Journals (Sweden)

    K.Swathi

    2014-09-01

    Full Text Available As technology scales into the nanometer regime leakage current, active power, delay and area are becoming important metric for the analysis and design of complex circuits. The main concern in mobile and battery based systems are leakage current and power dissipation. A transistor resizing approach for 10 transistor single bit full adder cells is used to determine optimal sleep transistor size which reduces power dissipation and leakage current. A submicron level 10-transistor single bit full adder cell is considered to achieve low leakage current, reduced power dissipation and high speed. In this paper initially 10T full adder cell is designed with submicron technique and later this is employed to design an ALU adder unit. The modified ALU is simulated and synthesized successfully on cadence 180nm technology.

  12. Synthesis and integration of Fe-soc-MOF cubes into colloidosomes via a single-step emulsion-based approach

    KAUST Repository

    Pang, Maolin

    2013-07-17

    Bottom-up fabrication of complex 3D hollow superstructures from nonspherical building blocks (BBs) poses a significant challenge for scientists in materials chemistry and physics. Spherical colloidal silica or polystyrene particles are therefore often integrated as BBs for the preparation of an emerging class of materials, namely colloidosomes (using colloidal particles for Pickering stabilization and fusing them to form a permeable shell). Herein, we describe for the first time a one-step emulsion-based technique that permits the assembly of metal-organic framework (MOF) faceted polyhedral BBs (i.e., cubes instead of spheres) into 3D hollow superstructures (or "colloidosomes" ). The shell of each resultant hollow MOF colloidosome is constructed from a monolayer of cubic BBs, whose dimensions can be precisely controlled by varying the amount of emulsifier used in the synthesis. © 2013 American Chemical Society.

  13. Development of the Embedded Protective Device Based on ARM

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-wen; LI Na; PAN Chun-de

    2005-01-01

    An embedded protective device for 35kV power line is worked out based on Philips' LPC2292 ARM MCU. Several aspects such as embedded design technique adopted in the system framework, application of adaptive theory in data acquisition, Board Support Packet (BSP) developing and task dispatching related to operating system are discussed. Both hardware and software framework of the system are given. Advanced hardware platform and software development environment is applied in design of the system, with the advanced co-design technology.

  14. ARM Processor Based Embedded System for Remote Data Acquisition

    Directory of Open Access Journals (Sweden)

    Raj Kumar Tiwari

    2014-01-01

    Full Text Available The embedded systems are widely used for the data acquisition. The data acquired may be used for monitoring various activity of the system or it can be used to control the parts of the system. Accessing various signals with remote location has greater advantage for multisite operation or unmanned systems. The remote data acquisition used in this paper is based on ARM processor. The Cortex M3 processor used in this system has in-built Ethernet controller which facilitate to acquire the remote data using internet. The system developed provides high performance, low power consumption, smaller size {&} high speed

  15. An ARM-based motor control system in EPICS

    International Nuclear Information System (INIS)

    In this paper,a motor control system,formed by a S3C2440 computer, the Linux operating system and a MAXnet motor controller,is developed in EPICS at SSRF(Shanghai Synchrotron Radiation Facility). A detailed analysis of the system design, and software development, are provided. It indicates that an ARM-based motor control system is feasible. Test results show that it has an equivalent performance in position control, with greatly reduced cost and volume, though the time response is not as good as the present motor control system. It provides a reference for designing new motor control systems of SSRF. (authors)

  16. VFI-based Robotic Arm Control for Natural Adaptive Motion

    Directory of Open Access Journals (Sweden)

    Woosung Yang

    2014-03-01

    Full Text Available Since neural oscillator based control methods can generate rhythmic motion without information on system dynamics, they can be a promising alternative to traditional motion planning based control approaches. However, for field application, they still need to be robust against unexpected forces or changes in environments so as to be able to generate “natural motion” like most biological systems. In this study a biologically inspired control algorithm that combines neural oscillators and virtual force is proposed. This work gives the condition with respect to parameters tuning to stably activate the neural oscillators. This is helpful to achieve motion adaptability to environmental changes keeping the motion repeatability. He efficacy and efficiency of the proposed methods are tested in the control of a planar three-linkage robotic arm. It is shown that the proposed controller generates a given circular path stably and repeatedly, even with unexpected contact with a wall. The adaptivity of motion control is also tested in control of a robotic arm with redundant degrees of freedom. The proposed control algorithm works throughout the simulations and experiments.

  17. The SOC Model of Forest Fires Based on Energy Random Distribution%基于能量随机分布的特大森林火灾SOC模型

    Institute of Scientific and Technical Information of China (English)

    杨帆; 杨青

    2014-01-01

    Through the analysis of the features of forest fire events,and its.evolution law,the extra large forest fires SOC (Self-Organized Criticality,SOC for short) model is presented based on energy random distribution.It better simulates the evolution process of extra large forest fires,and the result is close to the actual process of the extra large forest fires outbreak.Then the situational inference and small energy release mode are built based on the SOC model.Finally using multi-agents simulation technology,and extra large forest fire in Australia at 2009 as a prototype,the result shows that it represents the evolution of the extra large forest fires really,and shows they can work as fire control methods of changing the fire extinguishing efficiency or small energy release mode.%在分析森林火灾事件的特征、事件演变规律的基础上,提出了一种基于能量随机分布的特大森林火灾SOC (Self-Organized Criticality,简称SOC)模型,较好地模拟了特大森林火灾的演化过程,与实际的特大森林火灾爆发过程也比较吻合,并基于此构建了情景推演和小规模能量释放模型,最后运用多智能体仿真技术,以2009年澳大利亚森林火灾为原型进行模拟,结果很好地再现了特大森林火灾的演化过程,以及显示了灭火效率、小规模能量释放的方式对火灾的控制作用.

  18. Arm7 Based Evolution in Vehicle Mobility and Automation

    Directory of Open Access Journals (Sweden)

    Mr. N. S. Vaidya

    2013-09-01

    Full Text Available The “Arm7 Based Evolution In Vehicle Mobility And Automation”, various sensor is used to detect various parameters of the vehicle system like Temperature sensor is used to detect engine temperature, Light sensor is used to switch on head light at night automatically, proximity sensor are used for driver as well as driver side seat belt wearing information, figure print sensor are used to open the vehicle as well as start the car. Micro serial data card reader is used here to work as a black box of the vehicle, whenever accident happen it can give all the last information which is stored in to memory card to the investigator, which is easy to detect the cause of accident. The smartness of this vehicle is to tell all the information or sensor output data audibly to the vehicle owner or driver and driver side seat passenger. All the things can be controlled by one system which is ARM7 and information is also displayed on LCD monitor

  19. Simulation of Octopus Arm Based on Coupled CPGs

    Directory of Open Access Journals (Sweden)

    Juan Tian

    2015-01-01

    Full Text Available The octopus arm has attracted many researchers’ interests and became a research hot spot because of its amazing features. Several dynamic models inspired by an octopus arm are presented to realize the structure with a large number of degrees of freedom. The octopus arm is made of a soft material introducing high-dimensionality, nonlinearity, and elasticity, which makes the octopus arm difficult to control. In this paper, three coupled central pattern generators (CPGs are built and a 2-dimensional dynamic model of the octopus arm is presented to explore possible strategies of the octopus movement control. And the CPGs’ signals treated as activation are added on the ventral, dorsal, and transversal sides, respectively. The effects of the octopus arm are discussed when the parameters of the CPGs are changed. Simulations show that the octopus arm movements are mainly determined by the shapes of three CPGs’ phase diagrams. Therefore, some locomotion modes are supposed to be embedded in the neuromuscular system of the octopus arm. And the octopus arm movements can be achieved by modulating the parameters of the CPGs. The results are beneficial for researchers to understand the octopus movement further.

  20. Kinect-Based Sliding Mode Control for Lynxmotion Robotic Arm

    Directory of Open Access Journals (Sweden)

    Ismail Ben Abdallah

    2016-01-01

    Full Text Available Recently, the technological development of manipulator robot increases very quickly and provides a positive impact to human life. The implementation of the manipulator robot technology offers more efficiency and high performance for several human’s tasks. In reality, efforts published in this context are focused on implementing control algorithms with already preprogrammed desired trajectories (passive robots case or trajectory generation based on feedback sensors (active robots case. However, gesture based control robot can be considered as another channel of system control which is not widely discussed. This paper focuses on a Kinect-based real-time interactive control system implementation. Based on LabVIEW integrated development environment (IDE, a developed human-machine-interface (HMI allows user to control in real time a Lynxmotion robotic arm. The Kinect software development kit (SDK provides a tool to keep track of human body skeleton and abstract it into 3-dimensional coordinates. Therefore, the Kinect sensor is integrated into our control system to detect the different user joints coordinates. The Lynxmotion dynamic has been implemented in a real-time sliding mode control algorithm. The experimental results are carried out to test the effectiveness of the system, and the results verify the tracking ability, stability, and robustness.

  1. Arm locking for space-based laser interferometry gravitational wave observatories

    OpenAIRE

    Yu, Yinan; Mitryk, Shawn; Mueller, Guido

    2014-01-01

    Laser frequency stabilization is a critical part of the interferometry measurement system of space-based gravitational wave observatories such as the Laser Interferometer Space Antenna (LISA). Arm locking as a proposed frequency stabilization technique, transfers the stability of the long arm lengths to the laser frequency. The arm locking sensor synthesizes an adequately filtered linear combination of the inter-spacecraft phase measurements to estimate the laser frequency noise, which can be...

  2. The simple art of SoC design

    CERN Document Server

    Keating, Michael

    2011-01-01

    This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow's SoC designs.

  3. A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

    Directory of Open Access Journals (Sweden)

    Xiaoxue Qiu

    2012-06-01

    Full Text Available Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3 are inhibitors of the Janus tyrosine kinase (JAK/signal transducers and activators of transcription (STAT pathway and function in a negative feedback loop during cytokine signaling. Abl transformation is associated with constitutive activation of JAK/STAT-dependent signaling. However, the mechanism by which Abl oncoproteins bypass SOCS inhibitory regulation remains poorly defined. Here, we demonstrate that coexpression of Bcr-Abl with SOCS-1 or SOCS-3 results in tyrosine phosphorylation of these SOCS proteins. Interestingly, SOCS-1 is highly tyrosine phosphorylated in one of five primary chronic myelogenous leukemia samples. Bcr-Abl-dependent tyrosine phosphorylation of SOCS-1 and SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3. We observed that phosphorylation of these SOCS proteins was associated with their binding to Bcr-Abl. Bcr-Abl-dependent phosphorylation of SOCS-1 and SOCS-3 diminished their inhibitory effects on the activation of JAK and STAT5 and thereby enhanced JAK/STAT5 signaling. Strikingly, disrupting the tyrosine phosphorylation of SOCS-1 or SOCS-3 impaired the expression of Bcl-XL protein and sensitized K562 leukemic cells to undergo apoptosis. Moreover, selective mutation of tyrosine phosphorylation sites of SOCS-1 or SOCS-3 significantly blocked Bcr-Abl-mediated tumorigenesis in nude mice and inhibited Bcr-Abl-mediated murine bone marrow transformation. Together, these results reveal a mechanism of how Bcr-Abl may overcome SOCS-1 and SOCS-3 inhibition to constitutively activate the JAK/STAT-dependent signaling, and suggest that Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.

  4. Zigbee GPS Based Tracking System Using ARM 9

    Directory of Open Access Journals (Sweden)

    Y. Pavan Kumar Reddy

    2013-05-01

    Full Text Available Real Time person tracking is an important building block in advanced humanoid robots. The applications extend to small area security system like offices, hospitals, prisons, industries etc. There are various methods and some of them are now used in smart mobile applications using GSM-GPS, Sensor networks, vision based tracking system etc. But these are expensive to be used in day-to-day life. As far as concerned with the security systems the investments are high and in the case of humanoids the monitoring system is too huge for an automated machine. To overcome these issues, a simple hardware build-up is proposed. The proposed system is Real Time person location detection and tracking system consisting of ZIGBEE modules and GPS interfaced to ARM9 development board with an RTOS (WinCE or Embedded LINUX. The whole system has two parts namely Monitoring system and the Tags. Monitoring system acts as a server which processes the data received from the tags. Tags are match box size devices transmitting the locations based data to the monitoring system. This system has its own advantages of small size, Low power consumption, range flexibility and GUI. The measured results indicate that the developed system can track a person up to 20m with an accuracy of 5m

  5. Intelligent control system based on ARM for lithography tool

    Science.gov (United States)

    Chen, Changlong; Tang, Xiaoping; Hu, Song; Wang, Nan

    2014-08-01

    The control system of traditional lithography tool is based on PC and MCU. The PC handles the complex algorithm, human-computer interaction, and communicates with MCU via serial port; The MCU controls motors and electromagnetic valves, etc. This mode has shortcomings like big volume, high power consumption, and wasting of PC resource. In this paper, an embedded intelligent control system of lithography tool, based on ARM, is provided. The control system used S5PV210 as processor, completing the functions of PC in traditional lithography tool, and provided a good human-computer interaction by using LCD and capacitive touch screen. Using Android4.0.3 as operating system, the equipment provided a cool and easy UI which made the control more user-friendly, and implemented remote control and debug, pushing video information of product by network programming. As a result, it's convenient for equipment vendor to provide technical support for users. Finally, compared with traditional lithography tool, this design reduced the PC part, making the hardware resources efficiently used and reducing the cost and volume. Introducing embedded OS and the concepts in "The Internet of things" into the design of lithography tool can be a development trend.

  6. A Media Player Based On ARM by Porting of Linux

    OpenAIRE

    Archan Agrawal*; Mrs. Monika S. Joshi

    2014-01-01

    This paper describes the porting of embedded linux on ARM 9 platform for designing and implementing of embedded media player on S3Cmini2440 development board. A novel transplating method for linux kernel is presented here, Linux kernel as well as its cut,compile,and porting process under ARM platform are introduced. Optimized linux operating system in the processor has been installed and transplanted the SDL_FFMPEG library into S3Cmini2440 after the cross compilation. Ofthis whole...

  7. Wind Power Smoothing Method Using Hybrid Energy Storage System Based on SOC Hierarchical Optimization%基于荷电状态分级优化的混合储能风电功率平抑方法

    Institute of Scientific and Technical Information of China (English)

    邹见效; 戴碧蓉; 彭超; 辛晓帅; 骆伍巧

    2013-01-01

    为了弥补单一储能技术的不足,由超级电容和储能电池组成的混合储能系统越来越多地应用于风电功率平抑。为保证混合储能系统整体充放能力,并充分利用超级电容反应快和储能电池容量大的特点,文中提出了一种基于电池荷电状态(SOC)分级优化的混合储能系统风电功率平抑方法。该方法采用了分层结构,包含优化控制层和协调控制层。优化控制层根据风电平抑性能要求以及混合储能系统当前整体SOC,计算动态调节储能系统的设定功率;协调控制层根据储能设备各自的SOC和充放电特性,按优化控制层计算出的设定功率进行功率分配,以实现对设定功率的快速跟踪。仿真实验证明,该方法在保持风电平抑效果不变的情况下,维持了混合储能系统整体较高的充放能力,同时优化了储能设备的SOC,避免了储能设备的过充过放。%Hybrid energy storage,consisting of super capacitor and battery,has been widely applied to smooth wind power fluctuation because it can overcome the disadvantage of single energy storage technology.To ensure reliable charging and discharging performance of hybrid energy storage and fully take advantage of the characteristic of fast reaction of super capacitors and large capacity batteries,this paper proposes a wind power smoothing method using hybrid energy storage system based on hierarchical optimization of state of charge (SOC).This method adopts two-layer distributed control structure, including optimizing control layer and coordinated control layer.In the optimizing control layer,the target power of dynamic adjustment energy storage system is calculated according to the performance requirements of wind power smoothing and the current SOC of the system.In coordinated control layer,power distribution strategy is decided according to the SOC and charging and discharging characteristics of the energy storage devices and the target power

  8. Innovative Design of Plastic Bottle Recycling Box Based on ARM

    Directory of Open Access Journals (Sweden)

    Yuedong Xiong

    2014-04-01

    Full Text Available Aiming at the problems of on-site plastic bottles recycling and the reuse of waste, the automatic recycling system was developed on the basis of ARM. As the main controller, ARM not only controls the mechanical system of the collector to recover and break plastic bottles, but also communicates with and rewards the user by the automatic reward system through the wireless network. The experimental prototype test results show: post treated fragments of plastic bottles are small, which are convenient to transport and take advantage of; the operation of recovery is easy, and the interface of man-machine interaction is friendly which is easy to expand functions.

  9. Design of Global Location System Based on Embedded Linux Using ARM9

    Directory of Open Access Journals (Sweden)

    P. H. V. Narender

    2013-01-01

    Full Text Available Abstract: The design of Global location system based on ARM mainly build by Linux. The architecture and working of this system is introduced in details, and introduces the Global location system which uses the ARM microprocessor as a control unit interfaces with GPS and GPRS modules. In general GPS modules will give latitude and longitude values. Using these values we cannot predict location name to overcome this we had designed. In this paper we are developing a web page which links to Google map URL and the latitude and longitude values are passed to the web page with ARM processer. The main advantage of this system is the web page will be accessed on the ARM processor which has display unit also. By this the persons in mobile unit can also know the exact location with the map view. GPRS Connected to ARM processor for mobile communication where internet can be accessed.

  10. Settling-velocity specific SOC distribution on hillslopes

    Science.gov (United States)

    Hu, Yaxian; Asefaw Berhe, Asmeret; Fogel, Marilyn L.; Heckrath, Goswin J.; Kuhn, Nikolaus J.

    2016-04-01

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC is stored. In theory, the transport distances of soil fractions are related to their settling velocities under given flow conditions. Yet, very few field investigations have been conducted to examine the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The δ13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope during or after erosion-induced transport. Overall, our results illustrate that immediate deposition of fast settling soil fractions and the associated SOC at footslopes must be appropriately accounted for in attempts to quantify the role of soil erosion in terrestrial carbon sequestration. A SOC erodibility parameter based on actual settling velocity distribution of eroded fractions is needed to better calibrate soil erosion models.

  11. Optical Sensors Based on Single Arm Thin Film Waveguide Interferometer

    Science.gov (United States)

    Sarkisov, S. S.; Diggs, D.; Curley, M.; Adamovsky, Grigory (Technical Monitor)

    2001-01-01

    Single-arm double-mode double-order optical waveguide interferometer utilizes interference between two propagating modes of different orders. Sensing effect results from the change in propagation conditions of the modes caused by the environment. The waveguide is made as an open asymmetric slab structure containing a dye-doped polymer film onto a fused quartz substrate. It is more sensitive to the change of environment than its conventional polarimetric analog using orthogonal modes (TE and TM) of the same order. The sensor still preserves the option of operating in polarimetric regime using a variety of mode combinations such as TE(sub 0)/TM(sub 0) (conventional), TE(sub 0)/TM(sub 1), TE(sub 1)/TM(sub 0), or TE(sub 1)/TM(sub 1) but can also work in nonpolarimetric regime using combinations TE(sub 0)/TM(sub 1) or TE(sub 0)/TM(sub 1). Utilization of different mode combinations simultaneously makes the device more versatile. Application of the sensor to gas sensing is based on doping polymer film with an organic indicator dye sensitive to a particular gas. Change of optical absorption spectrum of the dye caused by the gaseous pollutant results change of the reactive index of the dye-doped polymer film that can be detected by the sensor. As an indicator dyes, we utilize Bromocresol Purple doped into polymer poly(methyl) methacrylate, which shows a reversible growth of the absorption peak neat 600 nm after exposure to wet ammonia. We have built a breadboard prototype of the sensor with He-Ne laser as a light source and with a single mode fiber input and a multimode fiber output. The prototype showed sensitivity to temperature change of the order of 2 C per one full oscillation of the signal. The sensitivity of the sensor to the presence of wet ammonia is 200 ppm per one full oscillation of the signal. The further improvements include switching to a longer wavelength laser source (750-nm semiconductor laser), substitution of poly(methyl) methacrylate with hydrophilic

  12. 基于SOC nRF24LE1的采煤机无线遥控系统的设计%Design of a remote control system for shearers based on SOC nRF24LE1

    Institute of Scientific and Technical Information of China (English)

    陈斯; 赵同彬; 游春霞

    2012-01-01

    A remote control system for the shearer was designed based on 2.4 GHz wireless SOC chip nRF24LE1.The system used nRF24LE1 as the core,and consisted of three parts that were palmtop remote controller,onboard transceiver and onboard PLC.The onboard transceiver collected all working parameters of the shearer and transmitted the data to the palmtop remote controller in wireless way,then the data displayed on LCD in real-time.At the same time,when receiving the button instructions,the onboard transceiver controlled all kinds of shearer actions by the onboard PLC.With the embedded high-performance microprocessors intelligent RF transceiver SOC chip nRF24LE1,the system possessed the features such as low cost,low power consumption and stable performance etc.%基于2.4GHz无线SOC芯片nRF24LE1设计了一种采煤机无线遥控系统。系统以nRF24LE1为核心,包括掌上摇控器、机载收发装置和机载PLC三部分。机载收发装置采集采煤机的各种工作参数,通过无线方式将数据传送至掌上遥控器,并实时显示在LCD上。机载收发装置接收到按键指令后,经机载PLC装置来控制采煤机的各种动作。由于采用了高性能的嵌入式微处理器智能射频收发SOC芯片nRF24LE1,系统具有低成本、低功耗及性能稳定等特点。

  13. ETHERNET PACKET PROCESSOR FOR SOC APPLICATION

    Directory of Open Access Journals (Sweden)

    Raja Jitendra Nayaka

    2012-07-01

    Full Text Available As the demand for Internet expands significantly in numbers of users, servers, IP addresses, switches and routers, the IP based network architecture must evolve and change. The design of domain specific processors that require high performance, low power and high degree of programmability is the bottleneck in many processor based applications. This paper describes the design of ethernet packet processor for system-on-chip (SoC which performs all core packet processing functions, including segmentation and reassembly, packetization classification, route and queue management which will speedup switching/routing performance. Our design has been configured for use with multiple projects ttargeted to a commercial configurable logic device the system is designed to support 10/100/1000 links with a speed advantage. VHDL has been used to implement and simulated the required functions in FPGA.

  14. Arm locking for space-based laser interferometry gravitational wave observatories

    CERN Document Server

    Yu, Yinan; Mueller, Guido

    2014-01-01

    Laser frequency stabilization is a critical part of the interferometry measurement system of space-based gravitational wave observatories such as the Laser Interferometer Space Antenna (LISA). Arm locking as a proposed frequency stabilization technique, transfers the stability of the long arm lengths to the laser frequency. The arm locking sensor synthesizes an adequately filtered linear combination of the inter-spacecraft phase measurements to estimate the laser frequency noise, which can be used to control the laser frequency. At the University of Florida we developed the hardware-based University of Florida LISA Interferometer Simulator (UFLIS) to study and verify laser frequency noise reduction and suppression techniques under realistic LISA-like conditions. These conditions include the variable Doppler shifts between the spacecraft, LISA-like signal travel times, optical transponders, realistic laser frequency and timing noise. We review the different types of arm locking sensors and discuss their expect...

  15. Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

    OpenAIRE

    Xue Li; Jiuchun Jiang; Caiping Zhang; Le Yi Wang; Linfeng Zheng

    2015-01-01

    State of charge (SOC) is one of the most important parameters in battery management system (BMS). There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. ...

  16. A Neural Network Based Collision Detection Engine for Multi-Arm Robotic Systems

    OpenAIRE

    Rana, A. S.; Zalzala, A.M.S.

    1996-01-01

    A neural ntwork is proposed for collision detection among multiple robotic arms sharing a common workspace. The structure of the neural network is a hybrid between Guassian Radial Basis Function (RBF) neural networks and Multi-layer perceptron back-propagation (BP) neural networks. This network is used to generate potential fields in the configuration space of the robotic arms. A path planning algorithm based on heuristics is presented. It is shown that this algorithm works better than the c...

  17. SOC 315 ash course tutorial/tutorial rank

    OpenAIRE

    hfjui

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   ASHFORD SOC 315 Week 1 Individual Assignment Cultural Background Summary ASHFORD SOC 315 Week 1 DQ 1 ASHFORD SOC 315 Week 1 DQ 2 ASHFORD SOC 315 Week 2 Individual Assignment Ethnocentrism Matrix ASHFORD SOC 315 Week 2 Individual Assignment Media Reaction Paper ASHFORD SOC 315 Week 2 DQ 1 and DQ 2 ASHFORD SOC 315 Week 3 Individual Assignment Intercultural Commu...

  18. A Vibration Control Method for the Flexible Arm Based on Energy Migration

    Directory of Open Access Journals (Sweden)

    Yushu Bian

    2015-01-01

    Full Text Available A vibration control method based on energy migration is proposed to decrease vibration response of the flexible arm undergoing rigid motion. A type of vibration absorber is suggested and gives rise to the inertial coupling between the modes of the flexible arm and the absorber. By analyzing 1 : 2 internal resonance, it is proved that the internal resonance can be successfully created and the exchange of vibration energy is existent. Due to the inertial coupling, the damping enhancement effect is revealed. Via the inertial coupling, vibration energy of the flexible arm can be dissipated by not only the damping of the vibration absorber but also its own enhanced damping, thereby effectively decreasing vibration. Through numerical simulations and analyses, it is proven that this method is feasible in controlling nonlinear vibration of the flexible arm undergoing rigid motion.

  19. SOC 203 uop course tutorial/tutorial rank

    OpenAIRE

    hiolnv

    2015-01-01

    For more course tutorials visit   www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 We...

  20. Research on Compound Display Connections to ARM Based Processors

    Directory of Open Access Journals (Sweden)

    T J V Subrahmanyeswara Rao

    2011-09-01

    Full Text Available An electronic display is used to present data visually by transmitting images as output device. Visual displays generate visual information according to the electrical input signal either by generation of light or modulation of available light. This is of two types analog or digital. Now-a-days usage of many displays gaining wide acceptance in many areas of applications like Workstations, Information Broad casting, video conferencing etc. connecting two or more displays to a personal computer is possible by adding extra hardware and accordingly software like device drivers which are often expensive. Power supply requirement for this dedicated task is almost same as personal computer which runs with various applications. In this paper we have implemented multiple display connection modes to an ARM processor and achieved great reduction of power supply for this dedicated task.

  1. Synthesis and application of rhodamine-based fluorescent probe dyes with spacer linker arm

    Institute of Scientific and Technical Information of China (English)

    Yong Gao; Jian Li Li; Zhen Shi

    2007-01-01

    When rhodamine-based fluorescent probe dyes are used to track target molecules they always perturb the behavior of target molecules because of steric hindrance effect.In order to minimize potential steric problems, a kind of rhodamine-based fluorescent probe dye with spacer linker arm was designed and synthesized and its application in immunofluorescence histochemistry was investigated.

  2. Robot-arm-based mobile HTS SQUID system for NDE of structures

    International Nuclear Information System (INIS)

    A robot-arm-based mobile HTS SQUID system was developed for NDE of fixed targets. To realize the system, active magnetic shielding technique using fluxgate as reference sensor for ambient field was applied to a cryocooler-based HTS SQUID gradiometer that was mounted on commercial robot-arm. In this technique, ambient field noise and pulse noise of 550 nT from robot were measured by the fluxgate near the SQUID, and then the fluxgate output was negatively fed back to generate compensation field around the SQUID and fluxgate. The noise from robot was reduced by a factor of about 20 and the shielding technique enabled the HTS SQUID to move in unshielded environment by the robot-arm without flux-trapping or unlocking at 10 mm/s. System noise measurement and inspection of hidden cracks in multi-layer composite-metal structure were demonstrated using the mobile SQUID-NDE system

  3. SOC 262 uop course tutorial/tutorial rank

    OpenAIRE

    deeri

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 4 Times, Rating: A+   SOC 262 Week 1 Assignment Racial and Ethnic Groups Matrix SOC 262 Week 2 Assignment: Racial and Ethnic Groups Matrix SOC 262 Week 3 Assignment Racism Presentation SOC 262 Week 4 Assignment New in America paper SOC 262 Week 5 Assignment Media and Race SOC 262 Week 5 Assignment Racial and Ethnic Relations Matrix Paper and Presentation    

  4. SOC 402 ash course tutorial/tutorial rank

    OpenAIRE

    numre

    2015-01-01

    ASHFORD SOC 402 Week 1 DQ 1 Three Sociological Perspectives ASHFORD SOC 402 Week 1 DQ 2 Qualitative vs. Quantitative Research & the Methods of Social Research ASHFORD SOC 402 Week 2 DQ 1 McDonaldization ASHFORD SOC 402 Week 2 DQ 2 Generational Differences in the Workplace ASHFORD SOC 402 Week 2 Assignment Women and Flexibility in the Workplace ASHFORD SOC 402 Week 3 DQ 1 Retirement ASHFORD SOC 402 Week 3 DQ 2 Sexual Harassment ASHFORD SOC 402 Week 3 Assignment Outline...

  5. Evaluation of inertial devices for the control of large, flexible, space-based telerobotic arms

    Science.gov (United States)

    Montgomery, Raymond C.; Kenny, Sean P.; Ghosh, Dave; Shenhar, Joram

    1993-01-01

    Inertial devices, including sensors and actuators, offer the potential of improving the tracking of telerobotic commands for space-based robots by smoothing payload motions and suppressing vibrations. In this paper, inertial actuators (specifically, torque-wheels and reaction-masses) are studied for that potential application. Batch simulation studies are presented which show that torque-wheels can reduce the overshoot in abrupt stop commands by 82 percent for a two-link arm. For man-in-the-loop evaluation, a real-time simulator has been developed which samples a hand-controller, solves the nonlinear equations of motion, and graphically displays the resulting motion on a computer workstation. Currently, two manipulator models, a two-link, rigid arm and a single-link, flexible arm, have been studied. Results are presented which show that, for a single-link arm, a reaction-mass/torque-wheel combination at the payload end can yield a settling time of 3 s for disturbances in the first flexible mode as opposed to 10 s using only a hub motor. A hardware apparatus, which consists of a single-link, highly flexible arm with a hub motor and a torque-wheel, has been assembled to evaluate the concept and is described herein.

  6. Design of interface for industrial CT data transfers system base on ARM9 and FPGA

    International Nuclear Information System (INIS)

    A design base on ARM9 microprocessor produced by samsung company and FPGA produced by altera company. Details on hardware connection technology between S3C2410 and FPGA via AHB bus. The design also introduce realization of the timing control of AHB bus in QuartusII environment and drivers development for AHB bus under the Linux operation system. The results realize the data transfer steadily and rapidly in Industrial CT Data Transfers System. The design display advantage of ARM and FPGA. And also give good instructions for other similar design on dual core. (authors)

  7. The design of multi-channel pulse amplitude analyzer based on ARM micro controller

    International Nuclear Information System (INIS)

    It introduces the design of multi-channel pulse amplitude analyzer based on embedded ARM micro-controller. The embedded and real-time system μC/OS-II builds up the real-time and stability of the system and advances the integration. (authors)

  8. The software design of acquisition system for nuclear pulse based on ARM

    International Nuclear Information System (INIS)

    This paper introduces, a new style data acquisition system, which can acquire and analyze nuclear pulse signal based on ARM and high speed ADC. The system adopts Visual C++ as software developing kit. Concerning the multiple threads technology and object oriented method on serial communication. (authors)

  9. 33 CFR 334.740 - Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area. 334.740 Section 334.740 Navigation and Navigable... REGULATIONS § 334.740 Weekley Bayou, an arm of Boggy Bayou, Fla., at Eglin Air Force Base; restricted area....

  10. Contrasting effects of deep ploughing of croplands and forests on SOC stocks and SOC bioavailability

    Science.gov (United States)

    Alcántara, Viridiana; Don, Axel; Vesterdal, Lars; Well, Reinhard; Nieder, Rolf

    2016-04-01

    Subsoils are essential within the global C cycle since they have a high soil organic carbon (SOC) storage capacity due to a high SOC saturation deficit. However, measures for enhancing SOC stocks commonly focus on topsoils. We assessed the long-term stability of topsoil SOC buried in cropland and forest subsoils by deep ploughing. Deep ploughing was promoted until the 1970s for breaking up hardpan and improving soil structure to optimize crop growth conditions. In forests deep ploughing is performed as a site preparation measure for afforestation of sandy soil aiming at increasing water availability in deeper layers and decreasing weed competition by burial of seeds. An effect of deep ploughing was the translocation of topsoil SOC into subsoils, with a concomitant mixing of SOC-poor subsoil material into the "new" topsoil horizon. Deep ploughed croplands and forests represent unique long-term "in-situ incubations" of SOC-rich material in subsoils in order to assess the effect of soil depth on SOC turnover. In this study, we sampled soil from five loamy and five sandy cropland sites as well as from five sandy forest sites, which were ploughed to 55-127 cm depth 25 to 53 years ago. Adjacent, equally managed but conventionally ploughed or not ploughed (forests) subplots were sampled as reference. On average 45 years after the deep ploughing operation, at the cropland sites, the deep ploughed soils contained 42±13 Mg ha‑1 more SOC than the reference subplots down to 100 cm depth. On the contrary, at the forest sites, the SOC stocks of the deep ploughed soils contained 18±9 Mg ha‑1 less SOC compared to the reference soils on average 38 years deep ploughing. These contrasting results can be explained, on the one hand, by the slower SOC accumulation in the newly formed topsoils of the deep ploughed forest soil (on average 48% lower SOC stocks in topsoil) compared to the croplands (on average 15% lower SOC stocks in topsoil). On the other hand, the buried topsoils at

  11. SOC NANOBASED INTEGRATED WIRELESS SENSOR SYSTEM

    Directory of Open Access Journals (Sweden)

    Penghua Sun

    2014-11-01

    Full Text Available Smart nanotechnology materials have been recently utilized in sensing applications. Carbon nanotube (CNT based SoC sensor systems have potential applications in various fields, including medical, energy, consumer electronics, computers, and HVAC (heating, ventilation, and air conditioning among others. In this study, a nanotechnology multisensory system was designed and simulated using Labview Software. The mathematical models were developed for sensing three physical quantities: temperature, gas, and pressure. Four CNT groups on a chip (two for gas sensor, one for temperature, and a fourth one for pressure were utilized in order to perform sensing multiple parameters. The proposed fabrication processes and the materials used were chosen to avoid the interference of these parameters on each other when detecting one of them. The simulation results were translated into analog voltage from Labview software, transmitted via Bluetooth network, and received on desktop computers within the vicinity of the sensor system. The mathematical models and simulation results showed as high as 95% accuracy in measuring temperature, and the 5% error was caused from the interference of the surrounding gas. Within 7% change in pressure was impacted by both temperature and gas interference.

  12. Development of control system for multi-converter high voltage power supply using programmable SoC

    International Nuclear Information System (INIS)

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments without any cost overhead. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred Nos of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL. This paper describes development of control system on Zynq All Programmable SoC for HVPS. (author)

  13. Cost Modeling for SOC Modules Testing

    Directory of Open Access Journals (Sweden)

    Balwinder Singh

    2013-08-01

    Full Text Available The complexity of the system design is increasing very rapidly as the number of transistors on Integrated Circuits (IC doubles as per Moore’s law.There is big challenge of testing this complex VLSI circuit, in which whole system is integrated into a single chip called System on Chip (SOC. Cost of testing the SOC is also increasing with complexity. Cost modeling plays a vital role in reduction of test cost and time to market. This paper includes the cost modeling of the SOC Module testing which contains both analog and digital modules. The various test cost parameters and equations are considered from the previous work. The mathematical relations are developed for cost modeling to test the SOC further cost modeling equations are modeled in Graphical User Interface (GUI in MATLAB, which can be used as a cost estimation tool. A case study is done to calculate the cost of the SOC testing due to Logic Built in Self Test (LBIST and Memory Built in Self Test (MBIST. VLSI Test engineers can take the benefits of such cost estimation tools for test planning.

  14. Test access to deeply embedded analog terminals within an A/MS SoC

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper presents a standard scalable and reconfigurable design for testability (SR DfT) in order to increase accessibility to deeply embedded A/MS cores and to limit application of costly off-chip mixed-signal testers. SR DfT is an oscillation-based wrapper compatible with digital embedded core-based SoC test methodologies. The impact of the optimized oscillation-based wrapper design on MS SoC testing is evaluated in two directions: area and test time. Experimental results are presented for several SoCs from the ITC'02 test benchmarks with inclusion of eight analog filters.

  15. Design of Objects Tracking System Based on ARM Embedded Platform

    Institute of Scientific and Technical Information of China (English)

    XU Mei; SONG Yong-duan; LV Shao-dong; LIU Zhi-long; HUANG Cong-ying

    2014-01-01

    In recent years, according to the need of intelligent video surveillance system increasing rapidly in metropolitan cities ,a design based on S3C2440 microprocessor and embedded Linux operating system is adopted for real-time video target tracking. However, it is very challenging as embedded systems usually afford limited processing power and limited resources. Therefore, to address this problem, a real-time tracking algorithm using multi-features based on compressive sensing is proposed and implemented. The algorithm uses multiple matrix as the projection matrix of the compressive sensing and the compressed date as the multiple features to extract useful information needed by tracking process. Functions and libraries in OpenCV which were developed by Intel Corporation are utilized for building the tracking algorithms. It is tested with variant video sequences and the results show that the algorithm achieves stable tracking for the target moved of the light changed.

  16. ARM Cortex M3 Based Collision Detection System

    OpenAIRE

    J.D.Prathusha#1 , K.S.Roy#2 , Mahaboob Ali

    2013-01-01

    This paper explains mainly about how to find out the vehicle location when met with an accident using GPS, ADXL sensor to release Air bag and sending message for aid using GSM.An automobile remote alarm system based on GSM communication network is introduced. The TC35 GSM module and ADXL sensor is combined with the system, vibration sensor and speed sensor are used to achieve short message service (SMS) . The shortcoming of traditional systems including low security and small alarming range i...

  17. Zigbee GPS Based Tracking System Using ARM 9

    OpenAIRE

    Y. Pavan Kumar Reddy; Y. Sunanda; S. Lokesh; T. Prahlad Reddy

    2013-01-01

    Real Time person tracking is an important building block in advanced humanoid robots. The applications extend to small area security system like offices, hospitals, prisons, industries etc. There are various methods and some of them are now used in smart mobile applications using GSM-GPS, Sensor networks, vision based tracking system etc. But these are expensive to be used in day-to-day life. As far as concerned with the security systems the investments are high and in the case of humanoids t...

  18. SpaceWire- Based Control System Architecture for the Lightweight Advanced Robotic Arm Demonstrator [LARAD

    Science.gov (United States)

    Rucinski, Marek; Coates, Adam; Montano, Giuseppe; Allouis, Elie; Jameux, David

    2015-09-01

    The Lightweight Advanced Robotic Arm Demonstrator (LARAD) is a state-of-the-art, two-meter long robotic arm for planetary surface exploration currently being developed by a UK consortium led by Airbus Defence and Space Ltd under contract to the UK Space Agency (CREST-2 programme). LARAD has a modular design, which allows for experimentation with different electronics and control software. The control system architecture includes the on-board computer, control software and firmware, and the communication infrastructure (e.g. data links, switches) connecting on-board computer(s), sensors, actuators and the end-effector. The purpose of the control system is to operate the arm according to pre-defined performance requirements, monitoring its behaviour in real-time and performing safing/recovery actions in case of faults. This paper reports on the results of a recent study about the feasibility of the development and integration of a novel control system architecture for LARAD fully based on the SpaceWire protocol. The current control system architecture is based on the combination of two communication protocols, Ethernet and CAN. The new SpaceWire-based control system will allow for improved monitoring and telecommanding performance thanks to higher communication data rate, allowing for the adoption of advanced control schemes, potentially based on multiple vision sensors, and for the handling of sophisticated end-effectors that require fine control, such as science payloads or robotic hands.

  19. Vision based motion planning of humanoid robot arm for grasping task

    International Nuclear Information System (INIS)

    This paper presents the robust and efficient motion control approach for a redundant humanoid arm of BHR-02 (Beijing Humanoid Robot-02). This work is based on the numerical algorithm for computing the Inverse Kinematics of redundant arm and stereo based vision system to detect the pose and position of target object. Forward recursion formula with backward cycle computation method is used to reach in the vicinity of target object. Then BFS (Broyden Fletcher Shanno) method is then used to grasp object in real-time. Vision is a very important non contact sensor for humanoid robots. A method combining visual feed forward and visual feedback is proposed. Visual feed forward facilitates the reach in the vicinity of the object and reduces the manipulation time. Visual feedback increases the robustness by compensating the weak calibration errors. Effectiveness of the proposed strategy is proved through experiments. (author)

  20. First experience with particle-in-cell plasma physics code on ARM-based HPC systems

    Science.gov (United States)

    Sáez, Xavier; Soba, Alejandro; Sánchez, Edilberto; Mantsinen, Mervi; Mateo, Sergi; Cela, José M.; Castejón, Francisco

    2015-09-01

    In this work, we will explore the feasibility of porting a Particle-in-cell code (EUTERPE) to an ARM multi-core platform from the Mont-Blanc project. The used prototype is based on a system-on-chip Samsung Exynos 5 with an integrated GPU. It is the first prototype that could be used for High-Performance Computing (HPC), since it supports double precision and parallel programming languages.

  1. The Redundant Arm Self-motion Control Based on Self-tuning Fuzzy PID Controller

    Institute of Scientific and Technical Information of China (English)

    Liu Yu(刘宇); Sun Lining; Du Zhijiang

    2004-01-01

    A fuzzy control algorithm based on self-tuning PID proportional factor is presented. To a certain degree, it overcomes robot motion control's nonlinearity and uncertainty caused by joints coupled and friction, and decreases overshoot of end manipulator's tracking desired curves. The controller's structure is very simple but effective. With this control method, a 7-DOF redundant arm's self-motion developed by the authors is investigated. Research results show that the said controller restrains track overshoot and possesses preferable merits.

  2. Study on New Smart Transformer Terminal Unit Based on ARM and GPRS Network

    OpenAIRE

    Na Wu; Yinjing Guo; Yongqin Wei; Aying Wei

    2013-01-01

    Distribution transformer is one of the most important power equipments in distribution network, whose running state exercises a great influence on the stability of the network. Transformer Terminal Unit (TTU) is an effective device to monitor the running state of transformers in the distribution automation system. In this paper, we study a new smart TTU which uses ARM7 series chip as processor, equipped with ATT7022B based electric meter module and GPRS module for remote data transmission con...

  3. Performance benefits of telerobotics and teleoperation - enhancements for an arm-based tank waste retrieval system

    International Nuclear Information System (INIS)

    This report evaluates telerobotic and teleoperational arm-based retrieval systems that require advanced robotic controls. These systems will be deployed in waste retrieval activities in Hanford's Single Shell Tanks (SSTs). The report assumes that arm-based, retrieval systems will combine a teleoperational arm and control system enhanced by a number of advanced and telerobotic controls. The report describes many possible enhancements, spanning the full range of the control spectrum with the potential for technical maturation. The enhancements considered present a variety of choices and factors including: the enhancements to be included in the actual control system, safety, detailed task analyses, human factors, cost-benefit ratios, and availability and maturity of technology. Because the actual system will be designed by an offsite vendor, the procurement specifications must have the flexibility to allow bidders to propose a broad range of ideas, yet build in enough restrictions to filter out infeasible and undesirable approaches. At the same time they must allow selection of a technically promising proposal. Based on a preliminary analysis of the waste retrieval task, and considering factors such as operator limitations and the current state of robotics technology, the authors recommend a set of enhancements that will (1) allow the system to complete its waste retrieval mission, and (2) enable future upgrades in response to changing mission needs and technological advances

  4. Performance benefits of telerobotics and teleoperation - enhancements for an arm-based tank waste retrieval system

    Energy Technology Data Exchange (ETDEWEB)

    Horschel, D.S. [Sandia National Labs., Albuquerque, NM (United States); Gibbons, P.W. [Westinghouse Hanford Co., Richland, WA (United States); Draper, J.V. [Oak Ridge National Lab., TN (United States)] [and others

    1995-06-01

    This report evaluates telerobotic and teleoperational arm-based retrieval systems that require advanced robotic controls. These systems will be deployed in waste retrieval activities in Hanford`s Single Shell Tanks (SSTs). The report assumes that arm-based, retrieval systems will combine a teleoperational arm and control system enhanced by a number of advanced and telerobotic controls. The report describes many possible enhancements, spanning the full range of the control spectrum with the potential for technical maturation. The enhancements considered present a variety of choices and factors including: the enhancements to be included in the actual control system, safety, detailed task analyses, human factors, cost-benefit ratios, and availability and maturity of technology. Because the actual system will be designed by an offsite vendor, the procurement specifications must have the flexibility to allow bidders to propose a broad range of ideas, yet build in enough restrictions to filter out infeasible and undesirable approaches. At the same time they must allow selection of a technically promising proposal. Based on a preliminary analysis of the waste retrieval task, and considering factors such as operator limitations and the current state of robotics technology, the authors recommend a set of enhancements that will (1) allow the system to complete its waste retrieval mission, and (2) enable future upgrades in response to changing mission needs and technological advances.

  5. Note: Model-based identification method of a cable-driven wearable device for arm rehabilitation

    Science.gov (United States)

    Cui, Xiang; Chen, Weihai; Zhang, Jianbin; Wang, Jianhua

    2015-09-01

    Cable-driven exoskeletons have used active cables to actuate the system and are worn on subjects to provide motion assistance. However, this kind of wearable devices usually contains uncertain kinematic parameters. In this paper, a model-based identification method has been proposed for a cable-driven arm exoskeleton to estimate its uncertainties. The identification method is based on the linearized error model derived from the kinematics of the exoskeleton. Experiment has been conducted to demonstrate the feasibility of the proposed model-based method in practical application.

  6. Developing an ARM based GNU/Linux Operating System for Single Board Computer – Cubietruck

    Directory of Open Access Journals (Sweden)

    S.Pravin Kumar

    2014-12-01

    Full Text Available The design and implementation of a Monolithic-Kernel Single Board Computer (SBC - Cubietruck GNU/Linux-like operating system on ARM platform in technical details, including boot loader design - UBOOT, building the Kernel - uImage, design of root file system and init process. The Single Board Computer Operating System (SBC OS is developed on Linux platform with GNU tool chain. The SBC OS can be used for both SBC system application development and related curriculum teaching. Single Board Computer like embedded system related curriculums are already become necessary components for undergraduate computer majors. The system is mainly designed for the purpose of technical research and curriculum based teaching and students to learn, study and more readable, of which the source codes can be provided to students, guiding them to design tiny operating system on ARM platform from scratch.

  7. A multiscale framework with extended Kalman filter for lithium-ion battery SOC and capacity estimation

    International Nuclear Information System (INIS)

    Highlights: ► We develop a mutiscale framework with EKF to estimate SOC and capacity. ► The framework is a hybrid of coulomb counting and adaptive filtering techniques. ► It decouples SOC and capacity estimation in terms of measurement and time-scale. ► Results verify the framework achieves higher accuracy and efficiency than dual EKF. -- Abstract: State-of-charge (SOC) and capacity estimation plays an essential role in many battery-powered applications, such as electric vehicle (EV) and hybrid electric vehicle (HEV). However, commonly used joint/dual extended Kalman filter (EKF) suffers from the lack of accuracy in the capacity estimation since (i) the cell voltage is the only measurable data for the SOC and capacity estimation and updates and (ii) the capacity is very weakly linked to the cell voltage. The lack of accuracy in the capacity estimation may further reduce the accuracy in the SOC estimation due to the strong dependency of the SOC on the capacity. Furthermore, although the capacity is a slowly time-varying quantity that indicates cell state-of-health (SOH), the capacity estimation is generally performed on the same time-scale as the quickly time-varying SOC, resulting in high computational complexity. To resolve these difficulties, this paper proposes a multiscale framework with EKF for SOC and capacity estimation. The proposed framework comprises two ideas: (i) a multiscale framework to estimate SOC and capacity that exhibit time-scale separation and (ii) a state projection scheme for accurate and stable capacity estimation. Simulation results with synthetic data based on a valid cell dynamic model suggest that the proposed framework, as a hybrid of coulomb counting and adaptive filtering techniques, achieves higher accuracy and efficiency than joint/dual EKF. Results of the cycle test on Lithium-ion prismatic cells further verify the effectiveness of our framework.

  8. Comparison Study on the Battery SoC Estimation with EKF and UKF Algorithms

    Directory of Open Access Journals (Sweden)

    Hongwen He

    2013-09-01

    Full Text Available The battery state of charge (SoC, whose estimation is one of the basic functions of battery management system (BMS, is a vital input parameter in the energy management and power distribution control of electric vehicles (EVs. In this paper, two methods based on an extended Kalman filter (EKF and unscented Kalman filter (UKF, respectively, are proposed to estimate the SoC of a lithium-ion battery used in EVs. The lithium-ion battery is modeled with the Thevenin model and the model parameters are identified based on experimental data and validated with the Beijing Driving Cycle. Then space equations used for SoC estimation are established. The SoC estimation results with EKF and UKF are compared in aspects of accuracy and convergence. It is concluded that the two algorithms both perform well, while the UKF algorithm is much better with a faster convergence ability and a higher accuracy.

  9. 基于65 nm工艺的SOC物理设计中的关键技术研究%Research on the critical technology of SOC physical design based on 65GP

    Institute of Scientific and Technical Information of China (English)

    沈良伟

    2013-01-01

    With the evolution of process, the development of integrated circuit has turned into ultra-deep submicron stage. Some problems such as the cost, performance, power consumption, signal integrity have become the critical issues in SOC (system on chip) design. Based on the module level physical design of 65GP technology in practical program, and in ultra-deep submicron, some key problems in the back-end of physical design of the chip are studied in detail, such as low-cost, congestion and signal integrity. Some new methods and new ideas are put forward, thus the delivery quality of sign off is improved and satisifed the requirements of tapeout.%  随工艺的演进,集成电路发展已经进入超深亚微米阶段,芯片的成本、性能、功耗、信号完整性等问题将成为制约SOC芯片设计的关键问题。文章基于65GP工艺的实际项目模块级物理设计,在现超深亚微米下,对芯片的低功耗、congestion、信号完整性等后端物理设计等关键问题进行了细致研究,并提出了一些新方法和新思想,从而提高了signoff的交付质量,完成了tapeout要求。

  10. Multimodal System Based on Electrooculography and Voice Recognition to Control a Robot Arm

    Directory of Open Access Journals (Sweden)

    José A. Martínez

    2013-07-01

    Full Text Available People with severe motor disorders cannot use their arms and/or hands to interact with the environment. In such cases, a human‐machine interface can be used to allow these people to perform activities of daily life. Voice recognition would be the best method to control a device devoted to help with these tasks, but this method is very dependent on the background noise and, under certain circumstances, it cannot be used successfully. In this sense, other methods must be included in the system to assist the voice recognition module. In this project, electrooculography (EOG has been selected due to its stability and robustness. This way, a multimodal system based on EOG and voice recognition has been developed to control a robotic arm. This paper presents the procedures designed to combine both methods to create a multimodal interface useful for disabled people. Tests presented in this document compare the skills of five different users while controlling the robotic arm to perform pick‐and‐place tasks. Task duration and accuracy have been measured to obtain specific scores that are used to evaluate both interaction methods independently and the multimodal combination of them. The system works successfully using both methods (EOG and voice recognition. In addition, the multimodal interface improves robustness and reduces the uncertainty generated by the environment when there is background noise.

  11. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation

    OpenAIRE

    Lin, H-Y; Lai, R-H; Lin, S-T; Lin, R-C; Wang, M-J; Lin, C-C; Lee, H-C; Wang, F-F; Chen, J-Y

    2012-01-01

    Mitochondria are highly motile organelles that constantly undergo fission and fusion. Impairment of mitochondrial dynamics is associated with mitochondrial dysfunction and is frequently linked to the pathogenesis of neurodegenerative diseases and cancer. We have previously shown that biallelic inactivation of the suppressor of cytokine signaling 6 (SOCS6) gene is a frequent event in human gastric cancer. In this study, we recapitulated the event of SOCS6 loss using a Lentivirus-based knockdow...

  12. SOC 331 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    chloechl

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 6 Times, Rating: A   SOC 331 Complete Course (Not final paper) Sociology - General Sociology Moral, Legal, and Religious Perspectives on Social Justice. In Chapter 1 of your textbook, justice is analyzed from three perspectives, each with its own set of relevant concepts. The text includes three case studies for consideration from each perspective. Select one (only one) of these case studies...

  13. Development of radon isotopes discrimination device by software delayed coincidence method based on ARM

    International Nuclear Information System (INIS)

    The software delayed coincidence counting technology was researched based on embedded system. The device based on ARM processor was constructed to record time serials information of nuclear pulse. According to the different half-life of Po short-life daughters of radon isotopes, a method of software delayed coincidence counting was used to discriminate radon isotopes. Experiment results of 220Rn and 219Rn standard source measurement show that the software delayed coincidence counting method is practical for discrimination measurement of low level activity of radon isotopes. The software method is an alternative to hardware one, and it can offer better convenience and flexibility. (authors)

  14. Performance analysis on network transmission for an ARM-based embedded Linux system

    International Nuclear Information System (INIS)

    Multi-level trigger architecture is commonly used in data acquisition systems for large scale high energy physics experiments. In multi-level architecture, data is sent to higher level systems through network, which is usually based on Ethernet technology. In order to improve system efficiency and find out optimization methods for data transmission,in this paper we describe the network data receiving process of Linux 2.4 kernel in terms of data flow that based on ARM platform, and combined with the data obtained from the kernel. Reasons of changing network performance are analyzed, too, and system optimization recommendations are given. (authors)

  15. Mach-Zehnder Interferometers with Asymmetric Modulation Arms in Applications of High Speed Silicon-on-Insulator Based Optical Switches

    Institute of Scientific and Technical Information of China (English)

    SUN Fei; YU Jin-Zhong

    2006-01-01

    @@ Modulation arms with different widths are introduced to Mach-Zehnder interferometers (MZIs) to obtain improved performance. Theoretical analysis and numerical simulation have shown that when the widths of the two arms are properly designed to achieve an inherent mπ/2 (m is an odd integer) optical phase difference between the arms, the asymmetric MZI presents higher modulation speed. Furthermore, the carrier-absorption induced divergence of insertion losses in silicon-on-insulator (SOI) based MZI optical switches can be obviously improved.

  16. SOC 402 ash course tutorial/tutorial rank

    OpenAIRE

    buiop

    2015-01-01

                    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A   ASHFORD SOC 402 Week 1 DQ 1 Three Sociological Perspectives ASHFORD SOC 402 Week 1 DQ 2 Qualitative vs. Quantitative Research & the Methods of Social Research ASHFORD SOC 402 Week 2 DQ 1 McDonaldization ASHFORD SOC 402 Week 2 DQ 2 Generational Differences in the Workplace A...

  17. Transport-distance specific SOC distribution: Does it skew erosion induced C fluxes?

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berbe, Asmerat Asefaw; Fogel, Marilyn L.;

    2016-01-01

    Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate. The...... emissions during or immediately after transport, must be appropriately accounted for in attempts to quantify the role of soil erosion in terrestrial C sequestration. A SOC erodibility parameter based on actual settling velocity distribution of eroded fractions is needed to better calibrate soil erosion...... depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC is stored. In theory, the transport distances of soil fractions are related to their settling velocities under given flow conditions. Yet, very few field investigations have been conducted to examine...

  18. Design of GPS embedded portable instrument for radon measurement based on ARM7

    International Nuclear Information System (INIS)

    At present, portable instruments for radon measurement are large in volume, poor in measurement sensitivity and digitized degree. We have designed a new portable instrument for radon measurement with GPS, new data acquisition and control circuit based on ARM7. It has higher sensitivity, accuracy and velocity. Embedded operation system (uc/OS-Ⅱ) was used in software design for increasing stability and operability. The results of field assay showed that the instrument can be used for radon measurement in geologic and hydrographic survey. (authors)

  19. Design and implementation of new sip-suction-online device based on ARM9

    International Nuclear Information System (INIS)

    In order to detect whether the nuclear fuel components are damaged when replacing them in the reactor of a nuclear power plant, a new sip-suction-online device is designed and introduced in this paper. The device is based on ARM9 processor, embedded linux operating system and Qt Embedded applications, with the functions of detection, display, control, alarm and storage. It can timely, accurately and reliably detect whether the nuclear fuel components are damaged in the environment of a nuclear power plant. (authors)

  20. Hardware-Software Co-Simulation for SOC Functional Verification

    Institute of Scientific and Technical Information of China (English)

    YAN Ying-jian; LIU Ming-ye

    2005-01-01

    A hardware-software co-simulation method for system on chip (SOC) design is discussed. It is based on an instruction set simulator (ISS) and an event-driven hardware simulator, and a bus interface model that is described in C language provides the interface between the two. The bus interface model and the ISS are linked into a singleton program the software simulator, which communicate with the hardware simulator through Windows sockets. The implementation of the bus interface model and the synchronization between hardware and software simulator are discussed in detail. Co-simulation control of the hardware simulator is also discussed.

  1. Communication Architecture Synthesis for Multi-bus SoC

    Directory of Open Access Journals (Sweden)

    Abdelkrim Zitouni

    2006-01-01

    Full Text Available In the systems on chip (SoC design, the synthesis of communication architecture constitutes the bottleneck which can affect the performances of the system. Various schemes and protocols can be necessary, just as various topologies of interconnection. To reduce the complexity of the communications refinement, we present in this study a model and a synthesis approach for multi-bus communication architecture containing centralized bridge. The automation of the arbiter synthesis step profited from a detailed attention. This stage generates a hierarchical arbiter integrating various priority arbitration modules. The proposed approach was integrated in a toolbox based environment

  2. DESIGN OF ARM BASED REAL TIME PERSONNEL MONITORING SYSTEM USING WI-FI TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Rekha George

    2013-01-01

    Full Text Available Nowadays we constantly come across the need to transfer remote data to monitor center which will be far away from the place of data acquisition. Traditional data acquisition system using wires cannot satisfy these requirements due to its heavy cost and impracticability. Embedded devices with network communication which makes it more powerful and easier to monitor and control remote data, is one of the major outcomes of the developments in the field of communication and networking technologies. This study presents the design of a real time personnel monitoring system based on wireless technology. ARM embedded processor and Wi-Fi module are used as hardware platform in this project. Data transfer over the wireless network is based on the TCP/IP protocol which is a part of the Wi-Fi module. Using this designed system an officer can monitor the personnel in the organization by opening a web page from a place that is geographically far. This system is based on the conversion of serial to wireless data which could be transferred over the wireless network to the server and also over the internet. At the completion of the design, the result shows that data is transferred between the ARM processor and the host system using the wireless network.

  3. Analog circuit design for communication SOC

    CERN Document Server

    Tu, Steve Hung-Lung

    2012-01-01

    This e-book provides several state-of-the-art analog circuit design techniques. It presents both empirical and theoretical materials for system-on-a-chip (SOC) circuit design. Fundamental communication concepts are used to explain a variety of topics including data conversion (ADC, DAC, S-? oversampling data converters), clock data recovery, phase-locked loops for system timing synthesis, supply voltage regulation, power amplifier design, and mixer design. This is an excellent reference book for both circuit designers and researchers who are interested in the field of design of analog communic

  4. SOCS3: A novel therapeutic target for cardioprotection.

    Science.gov (United States)

    Yasukawa, Hideo; Nagata, Takanobu; Oba, Toyoharu; Imaizumi, Tsutomu

    2012-10-01

    The suppressors of cytokine signaling (SOCS) family of proteins are cytokine-inducible inhibitors of Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) signaling pathways. Among the family, SOCS1 and SOCS3 potently suppress cytokine actions by inhibiting JAK kinase activities. The generation of mice lacking individual SOCS genes has been instrumental in defining the role of individual SOCS proteins in specific cytokine pathways in vivo; SOCS1 is an essential negative regulator of interferon-γ (IFNγ) and SOCS3 is an essential negative regulator of leukemia inhibitory factor (LIF). JAK-STAT3 activating cytokines have exhibited cardioprotective roles in the heart. The cardiac-specific deletion of SOCS3 enhances the activation of cardioprotective signaling pathways, inhibits myocardial apoptosis and fibrosis and results in the inhibition of left ventricular remodeling after myocardial infarction (MI). We propose that myocardial SOCS3 is a key determinant of left ventricular remodeling after MI, and SOCS3 may serve as a novel therapeutic target to prevent left ventricular remodeling after MI. In this review, we discuss the signaling pathways mediated by JAK-STAT and SOCS proteins and their roles in the development of myocardial injury under stress (e.g., pressure overload, viral infection and ischemia). PMID:24058778

  5. SOCS proteins in regulation of receptor tyrosine kinase signaling

    DEFF Research Database (Denmark)

    Kazi, Julhash U.; Kabir, Nuzhat N.; Flores Morales, Amilcar;

    2014-01-01

    signaling mediated by RTKs must be tightly regulated by interacting proteins including protein-tyrosine phosphatases and ubiquitin ligases. The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar...... proteins, SOCS1-7, and cytokine-inducible SH2-containing protein (CIS). A key feature of this family of proteins is the presence of an SH2 domain and a SOCS box. Recent studies suggest that SOCS proteins also play a role in RTK signaling. Activation of RTK results in transcriptional activation of SOCS......-encoding genes. These proteins associate with RTKs through their SH2 domains and subsequently recruit the E3 ubiquitin machinery through the SOCS box, and thereby limit receptor stability by inducing ubiquitination. In a similar fashion, SOCS proteins negatively regulate mitogenic signaling by RTKs. It is also...

  6. CPU/SoC/MCU CoreSight SoC-400:可配置的调试和追踪解决方案

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    ARM公司针对复杂片上系统(SoC)设计推出高度可配置的调试和追踪解决方案ARM CoreSight SoC-400。随着多核产品的日益普及,ARM CoreSight SoC-400提供了系统解决方案,适合移动电话、平板电脑等应用。

  7. Cache Performance Optimization for SoC Vedio Applications

    Directory of Open Access Journals (Sweden)

    Lei Li

    2014-07-01

    Full Text Available Chip Multiprocessors (CMPs are adopted by industry to deal with the speed limit of the single-processor. But memory access has become the bottleneck of the performance, especially in multimedia applications. In this paper, a set of management policies is proposed to improve the cache performance for a SoC platform of video application. By analyzing the behavior of Vedio Engine, the memory-friendly writeback and efficient prefetch policies are adopted. The experiment platform is simulated by System C with ARM Cotex-A9 processor model. Experimental study shows that the performance can be improved by the proposed mechanism in contrast to the general cache without Last Level Cache (LLC: up to 18.87% Hit Rate increased, 10.62% MM Latency and 46.43% CPU Read Latency decreased for VENC/16way/64bytes; up to 52.1% Hit Rate increased, 11.43% MM Latency and 47.48% CPU Read Latency decreased for VDEC/16way/64bytes, but with only 8.62% and 4.23% Bandwidth increased respectively

  8. Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

    Directory of Open Access Journals (Sweden)

    Xue Li

    2015-01-01

    Full Text Available State of charge (SOC is one of the most important parameters in battery management system (BMS. There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. By using a typical battery platform for vehicle applications with sensor noise and battery aging characterization, three popular and representative SOC estimation methods (extended Kalman filter, PI-controlled observer, and H∞ observer are compared on such robustness. The simulation and experimental results demonstrate that deterioration of SOC estimation accuracy under modeling errors resulted from aging and larger measurement noise, which is quantitatively characterized. The findings of this paper provide useful information on the following aspects: (1 how SOC estimation accuracy depends on modeling reliability and voltage measurement accuracy; (2 pros and cons of typical SOC estimators in their robustness and reliability; (3 guidelines for requirements on battery system identification and sensor selections.

  9. [The organizational bases for the building of a modern medical support system for the Armed Forces].

    Science.gov (United States)

    Chizh, I M

    1996-01-01

    In the article the problems concerning characteristic features of the local wars and armed conflicts, organization bases of construction of The Army and Fleet medical support modern system are discussed. The organization of personnel medical security is considered depending on the duration, intensity and spatial scope of military conflict, peculiarities of group (forces) application and ways of military actions conduction. The distribution of federal troops sanitary losses during the war in Chechenskaya Republic is shown depending on the type, localization and degree of injuries gravity as well as volume of the wounded and invalids evacuation by air transport and work of military medical institutions. The following principles of construction of the Armed Forces medical support system are formulated: The system must be in compliance with troops goals, structure, strategy and tactics, its specificity; development of medical security forms and methods, their historicism; interdependency, completeness and integrity of the system's elements; territorial aspects of its construction and management optimization. Considering character of the goals being laid on the Mobile Forces the paramount importance is attached to the level of readiness of medical service and its formations and units to act in crisis situations. PMID:8659162

  10. Study on New Smart Transformer Terminal Unit Based on ARM and GPRS Network

    Directory of Open Access Journals (Sweden)

    Na Wu

    2013-12-01

    Full Text Available Distribution transformer is one of the most important power equipments in distribution network, whose running state exercises a great influence on the stability of the network. Transformer Terminal Unit (TTU is an effective device to monitor the running state of transformers in the distribution automation system. In this paper, we study a new smart TTU which uses ARM7 series chip as processor, equipped with ATT7022B based electric meter module and GPRS module for remote data transmission control. We focus on the corresponding hardware, software design and the measurement principle of harmonics of TTU. The new TTU can measure the electric parameters of the distribution transformer precisely. Taking advantage of the powerful ARM processor, it can analyze harmonic of the power line effectively. Due to the always-on-line feature of GPRS, TTU can achieve reliable communication with the remote terminal and the master station. Compared with other similar units, the new unit outperforms in terms of real-time, precision and reliability, which can fully meet with the high-speed development of distribution automation system.

  11. DMPD: An arms race: innate antiviral responses and counteracting viral strategies. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18031256 An arms race: innate antiviral responses and counteracting viral strategie...s. Schroder M, Bowie AG. Biochem Soc Trans. 2007 Dec;35(Pt 6):1512-4. (.png) (.svg) (.html) (.csml) Show An arms race...: innate antiviral responses and counteracting viral strategies. PubmedID 18031256 Title An arms race

  12. Hardware-Software Co-implementation of H.264 Decoder in SoC

    Institute of Scientific and Technical Information of China (English)

    YANG Yu-hong; ZHANG Wen-jun; XIONG Lian-xue; RAO Zhen-ning

    2006-01-01

    With the increasing demand for flexible and efficient implementation of image and video processing algorithms, there should be a good tradeoff between hardware and software design method. This paper utilized the HW-SW codesign method to implement the H. 264 decoder in an SoC with an ARM core, a multimedia processor and a deblocking filter coprocessor. For the parallel processing features of the multimedia processor, clock cycles of decoding process can be dramatically reduced. And the hardware dedicated deblocking filter coprocessor can improve the efficiency a lot. With maximum clock frequency of 150 MHz, the whole system can achieve real time processing speed and flexibility.

  13. SOCS3 silencing attenuates eosinophil functions in asthma patients.

    Science.gov (United States)

    Zafra, Ma Paz; Cañas, Jose A; Mazzeo, Carla; Gámez, Cristina; Sanz, Veronica; Fernández-Nieto, Mar; Quirce, Santiago; Barranco, Pilar; Ruiz-Hornillos, Javier; Sastre, Joaquín; del Pozo, Victoria

    2015-01-01

    Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high levels of suppressor of cytokine signaling 3 (SOCS3). In this article, SOCS3 gene silencing in eosinophils from asthmatics has been carried out to achieve a better understanding of the suppressor function in eosinophils. SOCS3 siRNA treatment drastically reduced SOCS3 expression in eosinophils, leading to an inhibition of the regulatory transcription factors GATA-3 and FoxP3, also interleukin (IL)-10; in turn, an increased STAT3 phosphorilation was observed. Moreover, SOCS3 abrogation in eosinophils produced impaired migration, adhesion and degranulation. Therefore, SOCS3 might be regarded as an important regulator implicated in eosinophil mobilization from the bone marrow to the lungs during the asthmatic process. PMID:25764157

  14. SOCS3 Silencing Attenuates Eosinophil Functions in Asthma Patients

    Directory of Open Access Journals (Sweden)

    Mª Paz Zafra

    2015-03-01

    Full Text Available Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high levels of suppressor of cytokine signaling 3 (SOCS3. In this article, SOCS3 gene silencing in eosinophils from asthmatics has been carried out to achieve a better understanding of the suppressor function in eosinophils. SOCS3 siRNA treatment drastically reduced SOCS3 expression in eosinophils, leading to an inhibition of the regulatory transcription factors GATA-3 and FoxP3, also interleukin (IL-10; in turn, an increased STAT3 phosphorilation was observed. Moreover, SOCS3 abrogation in eosinophils produced impaired migration, adhesion and degranulation. Therefore, SOCS3 might be regarded as an important regulator implicated in eosinophil mobilization from the bone marrow to the lungs during the asthmatic process.

  15. Self-reported and performance-based outcomes using DEKA Arm

    OpenAIRE

    Linda Resnik, PT, PhD, OCS; Matthew Borgia, MS; Gail Latlief, DO; Nicole Sasson, MD; Lisa Smurr-Walters, MS, OTR/L, CHT

    2014-01-01

    Mechanical properties of the DEKA Arm and associated engineering innovations are easy to observe. What is less clear is how these advances translate into functional benefits for the user with amputation. Study aims were to (1) quantify outcomes including dexterity, performance of daily activities, and prosthetic skill and spontaneity of users of the DEKA Arm and (2) compare outcomes when using the DEKA Arm with scores using the existing prosthesis. This was a quasi-experimental study. Descrip...

  16. Concise Arm and Hand Rehabilitation Approach in Stroke (CARAS: A practical and evidence-based framework for clinical rehabilitation management

    Directory of Open Access Journals (Sweden)

    Johan A. Franck

    2015-10-01

    Full Text Available The volume of information on new treatment techniques supporting the restoration of arm-hand function (AHF and arm-hand skill performance (ASHP in stroke survivors overwhelms therapists in everyday clinical practice when choosing the appropriate therapy. The Concise Arm and Hand Rehabilitation Approach in Stroke (CARAS is designed for paramedical staff to structure and implement training of AHF and AHSP in stroke survivors. The CARAS is based on four constructs: (a stratification according to the severity of arm–hand impairment (using the Utrecht Arm/Hand -Test [UAT], (b the individual’s rehabilitation goals and concomitant potential rehabilitation outcomes, (c principles of self-efficacy, and (d possibilities to systematically incorporate (new technology and new evidence-based training elements swiftly. The framework encompasses three programs aimed at treating either the severely (UAT 0-1, moderately (UAT 2-3, or mildly (UAT 4-7 impaired arm-hand. Program themes are: taking care of the limb and prevention of complications (Program 1, task-oriented gross motor grip performance (Program 2, and functional AHSP training (Program 3. Each program is preceded and followed by an assessment. Training modularity facilitates rapid interchange/adaptation of sub-elements. Proof-of-principle in clinical rehabilitation has been established. The CARAS facilitates rapid structured design and provision of state-of-the-art AHF and ASHP treatment in stroke patients.

  17. Hardware design of HIRFL-CSR EVMEbus controller based on ARM920T

    International Nuclear Information System (INIS)

    The HIRFL-CSR EVMEbus controller is developed in IMP. The controller is based on AT91RM9200 (ARM9) microprocessor, which is in 0.8 mm BGA package. The controller runs LINUX OS, and can connect with standard VGA display, keyboard, and mouse. There are 10 M/100 M Ethernet, USB, RS-232, RS-485 and CANBUS interfaces on the board. Itr supports storage devices SD Card and CF Card. The backboard interface logic is programmed in VHDL and is programmed into an in-system configurable FPGA device. The bus can drive high current up to 64 mA. It is not only compliant to VME specification, but also has flexibility of the programmable signal definition. Being a key module in HIRFL-CSR control system, the controller can be used as a local controller and also a remote gateway controller. (authors)

  18. Hardware design of radiation therapy table control system based on ARM and FPGA

    International Nuclear Information System (INIS)

    Based on the actual needs of the patient positioning system in Lanzhou heavy ion cancer treatment facility, the hardware of radiation therapy table control system is designed. After fully research and consideration, ARM and FPGA are chose to be the core architecture of this hardware system. The architecture of the three PCB boards in hardware system and the system design of A3P250 FPGA in the core controllers are illustrated in detail. Moreover, important interface protocols such as CANopen, SSI interface are also introduced and the hardware circuit implementations are showed. The hardware design is fully taken into account in the project to meet the control requirements for radiation therapy table of the patient positioning system. (authors)

  19. Replantation (Finger, Hand, or Arm)

    Science.gov (United States)

    ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ...

  20. SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children

    Directory of Open Access Journals (Sweden)

    Witold Szaflarski

    2012-01-01

    Full Text Available Suppressors of Cytokine Signaling (SOCS inhibit Signal Transducers and Activators of Transcription (STATs phosphorylation by binding and inhibiting Janus Kinases (JaKs. The aim of the present study was to evaluate the influence of glucocorticosteroids on the JaK/STAT signaling pathway in the leukocytes of nephrotic syndrome (NS patients. The study group was composed of 34 steroid sensitive NS (SSNS children and 20 steroid resistant NS (SRNS subjects. Gene expression was assessed by real-time PCR using pre-designed human JaK/STAT PCR array. Protein expression was evaluated using ELISA assay (plasma concentration and immunofluorescence (in situ protein expression. In SSNS children, the initial increased expression of JaK1, JaK2, JaK3, STAT1, STAT2, STAT6, TYK2, SOCS1, SOCS2, SOCS3, SOCS4 and SOCS5 was reduced back to the control limits. Similarly, in SRNS patients the increased levels of almost all mRNA expressions for the abovementioned genes were decreased, with the exceptions of SOCS3 and SOCS5 expressions. These mRNA expressions were still significantly increased and correlated with early unfavorable course of nephrotic syndrome in children. Plasma levels of SOCS3, SOCS5, IL-6 and IL-20 were significantly increased in SRNS subjects after six weeks of steroids medication compared to SSNS and control participants. We conclude that SOCS3 and SOCS5 increased mRNA expressions might predict initial resistance to steroids in NS patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 719–728

  1. Kinematics and control of redundant robotic arm based on dielectric elastomer actuators

    Science.gov (United States)

    Branz, Francesco; Antonello, Andrea; Carron, Andrea; Carli, Ruggero; Francesconi, Alessandro

    2015-04-01

    Soft robotics is a promising field and its application to space mechanisms could represent a breakthrough in space technologies by enabling new operative scenarios (e.g. soft manipulators, capture systems). Dielectric Elastomers Actuators have been under deep study for a number of years and have shown several advantages that could be of key importance for space applications. Among such advantages the most notable are high conversion efficiency, distributed actuation, self-sensing capability, multi-degree-of-freedom design, light weight and low cost. The big potentialities of double cone actuators have been proven in terms of good performances (i.e. stroke and force/torque), ease of manufacturing and durability. In this work the kinematic, dynamic and control design of a two-joint redundant robotic arm is presented. Two double cone actuators are assembled in series to form a two-link design. Each joint has two degrees of freedom (one rotational and one translational) for a total of four. The arm is designed to move in a 2-D environment (i.e. the horizontal plane) with 4 DoF, consequently having two degrees of redundancy. The redundancy is exploited in order to minimize the joint loads. The kinematic design with redundant Jacobian inversion is presented. The selected control algorithm is described along with the results of a number of dynamic simulations that have been executed for performance verification. Finally, an experimental setup is presented based on a flexible structure that counteracts gravity during testing in order to better emulate future zero-gravity applications.

  2. SOCS1 and SOCS3 are expressed in mononuclear cells in human cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation

    Science.gov (United States)

    Shin, Seung-Hwan; Lee, Ji Yoon; Lee, Tae Hyang; Park, So-Hye; Yahng, Seung-Ah; Yoon, Jae-Ho; Lee, Sung-Eun; Cho, Byung-Sik; Lee, Dong-Gun; Kim, Yoo-Jin; Lee, Seok; Min, Chang-Ki; Cho, Seok-Goo; Kim, Dong-Wook; Lee, Jong-Wook; Min, Woo-Sung; Park, Chong-Won

    2015-01-01

    Background The expression of the SOCS genes in cytomegalovirus (CMV) viremia after hematopoietic stem cell transplantation (HSCT) remains largely unexplored. Methods Using quantitative RT-PCR of mononuclear cells, we conducted pairwise comparison of SOCS1 and SOCS3 expression levels among a healthy donor group (N=55), a pre-HSCT group (N=17), and the recipient subgroup (N=107), which were divided according to the occurrence of CMV viremia and acute graft-versus-host disease (aGVHD). Results Compared to that in the healthy donor group, SOCS1 expression was higher in the CMV+ subgroup, especially in the CMV+GVHD- group, but decreased in the other subgroups. When compared to the expression in the pre-HSCT group, SOCS1 expression was significantly higher in the CMV+ subgroup, especially in the CMV+GVHD+ subgroup. Meanwhile, compared to that in the healthy donor group, SOCS3 expression was significantly lower in all other groups. The CMV-GVHD- subgroup showed significantly lower SOCS3 expression compared to the CMV+ subgroup, the CMV+GVHD+ subgroup, and the CMV+GVHD- subgroup. Conclusion We report differential expression of SOCS genes according to CMV viremia with acute GVHD occurrence after HSCT, suggesting that regulation of SOCS expression is associated with CMV viremia. PMID:25830129

  3. Human-Like Behavior Generation Based on Head-Arms Model for Robot Tracking External Targets and Body Parts.

    Science.gov (United States)

    Zhang, Zhijun; Beck, Aryel; Magnenat-Thalmann, Nadia

    2015-08-01

    Facing and pointing toward moving targets is a usual and natural behavior in daily life. Social robots should be able to display such coordinated behaviors in order to interact naturally with people. For instance, a robot should be able to point and look at specific objects. This is why, a scheme to generate coordinated head-arm motion for a humanoid robot with two degrees-of-freedom for the head and seven for each arm is proposed in this paper. Specifically, a virtual plane approach is employed to generate the analytical solution of the head motion. A quadratic program (QP)-based method is exploited to formulate the coordinated dual-arm motion. To obtain the optimal solution, a simplified recurrent neural network is used to solve the QP problem. The effectiveness of the proposed scheme is demonstrated using both computer simulation and physical experiments. PMID:25252290

  4. Aging and work: how do SOC strategies contribute to job performance across adulthood?

    Science.gov (United States)

    Yeung, Dannii Y; Fung, Helene H

    2009-12-01

    The authors examined the impacts of selection, optimization, and compensation (SOC) strategies-elective selection, loss-based selection, optimization, and compensation-on job performance across adulthood. A cross-sectional survey (Study 1, N=355) and a 5-day experience sampling study (Study 2, N=87) were conducted to assess Chinese insurance sales workers' global and momentary employment of SOC strategies at work and compare the effectiveness of these strategies in predicting their job performance. Study 1 revealed that the use of compensation predicted higher performance maintenance among older workers, whereas the use of elective selection contributed positively to sales productivity for both age groups, with stronger association for younger workers. Study 2 demonstrated that the positive impact of SOC strategies on global and momentary measures of job performance differed across tasks with various difficulty levels. When the task was perceived as highly difficult, older workers' greater use of elective selection predicted higher self-rated task performance; however, the positive association was weaker among younger workers. Older workers' greater use of the 4 SOC strategies was positively associated with sales increases when the task was not difficult or moderately difficult, yet the relationship was negative when the task was highly difficult. A reverse pattern was observed among younger workers. This article contributes to the understanding of working adults' psychological adaptation to the process of aging and reveals the moderating role of task difficulty on the association between SOC strategies and performance outcomes. PMID:20025407

  5. Network-based study on the relationship between arms exports and foreign policies

    Science.gov (United States)

    Chen, Xing; Zhao, Ru-lan; Zhang, Zi-ke; Zhao, Jing

    2016-02-01

    According to the data of arms exports of the top 20 largest arms exports countries in 1993-2012, an arms exports network is constructed to study the relationship of the exporters. Then the topological properties of the network and its minimal spanning tree are calculated to weigh the influence and importance of a country in all exporters, and the time evolution of the properties. It turns out that the properties fluctuate with the time. Consequently, the correlations of the arms exporters are discussed with the recipients during and after the wars. Besides, a time delayed network is constructed. The correlations of the exporters with time lag are discussed by filtering the time delayed network in different ways. The interactions between the exporters are visualized after filtering. This study may shed new light on how arms exports reflect foreign policies.

  6. Detecting Illegal Arms Trade

    OpenAIRE

    DellaVigna, Stefano; Ferrara, Eliana La

    2010-01-01

    Illegal arms are responsible for thousands of deaths in civil wars every year. Yet, their trade is very hard to detect. We propose a method to statistically detect illegal arms trade based on the investor knowledge embedded in financial markets. We focus on eight countries under UN arms embargo in the period 1990-2005, and analyze eighteen events during the embargo that suddenly increase or decrease conflict intensity. If the weapon-making companies are not trading or are trading legally, an ...

  7. Design & Implementation of a Low Cost Based Wireless HCI System for Disabled Persons Using ARM7

    Directory of Open Access Journals (Sweden)

    Surya Narayan Pradhan

    2014-05-01

    Full Text Available This paper focuses on design & development of a portable wireless Human Computer Interface (HCI system to create a robust hands free interface for disabled peoples or peoples having upper limb motor paralysis. Early techniques mainly considered image processing, gaze tracking and cameras to synthesis the device. We propose a new mouse as an input device for a computer whose operation is based on measurement of rotations of the user‘s head and detection of eye blinks. A tilt sensor(3-axis accelerometer is used to detect both lateral and vertical head movements to navigate the mouse cursor position placed on a helmet .The IR based eye blink sensor is placed on a spec used to detect eye blink and in turns do clicking operation. The signals are sent to the micro-controller (ARM7 LPC2148 for processing & do required operations. The wireless technology includes Zigbee module used to sends signals to the computer in use. A C# based program is developed for the mouse control operations & provides a flexible method for the disabled people to improve both personal & professional life quality.

  8. Stereocomplexation in Copolymer Networks Incorporating Enantiomeric Glycerol-Based 3-Armed Lactide Oligomers and a 2-Armed ɛ-Caprolactone Oligomer

    Directory of Open Access Journals (Sweden)

    Ayaka Shibita

    2016-07-01

    Full Text Available The reactions of enantiomeric glycerol-based 3-armed lactide oligomers (H3DLAO and H3LLAO and a diethylene glycol-based 2-armed ɛ-caprolactone oligomer (H2CLO with hexamethylene diisocyanate (HDI produced polyesterurethane copolymer networks (PEU-3scLAO/2CLOs 100/0, 75/25, 50/50, 25/75 and 0/100 with different feed ratios of stereocomplex (sc lactide oligomer (H3scLAO = H3DLAO + H3LLAO, H3DLAO/H3LLAO = 1/1 and H2CLO. Thermal and mechanical properties of the copolymer networks were compared with those of a simple homochiral (hc network (PEU-3DLAO produced by the reaction of H3DLAO and HDI. X-ray diffraction and differential scanning calorimetric analyses revealed that sc crystallites are formed without any hc crystallization for PEU-3scLAO/2CLOs, and that PEU-3DLAO is amorphous. The melting temperatures of sc crystallites for PEU-3scLAO/2CLOs were much higher than that of hc crystallites of H3DLAO. The polarized optical microscopic analysis revealed that the nucleation efficiency is enhanced with increasing feed of H3scLAO fraction, whereas the spherulite growth rate is accelerated with increasing feed H2CLO fraction over 100/0-50/50 networks. PEU-3scLAO/2CLO 100/0 (i.e., PEU-3scLAO exhibited a higher tensile strength and modulus than PEU-3DLAO. The elongation at break and tensile toughness for PEU-3scLAO/2CLOs increased with an increasing feed amount of H2CLO.

  9. FXR induces SOCS3 and suppresses hepatocellular carcinoma.

    Science.gov (United States)

    Guo, Fei; Xu, Zhizhen; Zhang, Yan; Jiang, Peng; Huang, Gang; Chen, Shan; Lyu, Xilin; Zheng, Ping; Zhao, Xin; Zeng, Yijun; Wang, Shuguang; He, Fengtian

    2015-10-27

    Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role in protecting against hepatocellular carcinoma (HCC). However, it is unclear whether the tumor suppressive activity of FXR involves the regulation of SOCS3. In the present study, we found that activation of FXR by its specific agonist GW4064 in HCC cells inhibited cell growth, induced cell cycle arrest at G1 phase, elevated p21 expression and repressed STAT3 activity. The above anti-tumor effects of FXR were dramatically alleviated by knockdown of SOCS3 with siRNA. Reporter assay revealed that FXR activation enhanced the transcriptional activity of SOCS3 promoter. Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assay displayed that FXR directly bound to IR9 DNA motif within SOCS3 promoter region. The in vivo study in nude mice showed that treatment with FXR ligand GW4064 could decelerate the growth of HCC xenografts, up-regulate SOCS3 and p21 expression and inhibit STAT3 phosphorylation in the xenografts. These results suggest that induction of SOCS3 may be a novel mechanism by which FXR exerts its anti-HCC effects, and the FXR-SOCS3 signaling may serve as a new potential target for the prevention/treatment of HCC. PMID:26416445

  10. Expression of SOCS-3 and Its Methylation in Renal Cancer

    Institute of Scientific and Technical Information of China (English)

    YU Jing; ZHAO Li-chun; YAO Song-mei; HE Cheng-yan; LI Hong-jun; KONG Xiang-bo

    2011-01-01

    The expression level of suppressor of cytokine signaling-3(SOCS-3) in human renal carcinoma and its methylation state were investigated. Reverse transcription-polymerase chain reaction(RT-PCR), immuocytochemistry,immunohistochemistry and Western blot were used to detect the expression level of SOCS-3, and the methylation of SOCS gene was investigated by methylation specific PCR in the tissues of i 5 cases of renal carcinoma. Compared to those of the normal renal cell line and specimens, the expression level of SOCS-3 in renal carcinoma was significantly lower or can't be detected(P<0.01). And the methylation of SOCS-3 gene in the tissue of renal carcinoma was significantly higher. The expression of SOCS-3 gene is significantly lower in renal carcinoma and the high methylation of the promoter island of SOCS-3 gene is associated with the lower expression of SOCS-3 gene. It may be one of main mechanisms for the development and progress of renal carcinoma.

  11. Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3 Function and Expression

    Directory of Open Access Journals (Sweden)

    Jamie J. L. Williams

    2014-05-01

    Full Text Available The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3, its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.

  12. Self-reported and performance-based outcomes using DEKA Arm

    Directory of Open Access Journals (Sweden)

    Linda Resnik, PT, PhD

    2014-06-01

    Full Text Available Mechanical properties of the DEKA Arm and associated engineering innovations are easy to observe. What is less clear is how these advances translate into functional benefits for the user with amputation. Study aims were to (1 quantify outcomes including dexterity, performance of daily activities, and prosthetic skill and spontaneity of users of the DEKA Arm and (2 compare outcomes when using the DEKA Arm with scores using the existing prosthesis. This was a quasi-experimental study. Descriptive analyses examined outcomes by DEKA Arm configuration level. Of the 39 subjects fit with a DEKA Arm, 32 were trained in use and completed end-of-study testing. Data from 26 prosthetic users were used to compare outcomes using existing prostheses with outcomes with the DEKA Arm. Dexterity and activity performance with the DEKA Arm varied by amputation level (p < 0.01. Self-reported function and number of activities performed using the prosthesis were similar across levels. Comparisons with existing prostheses showed the effect on dexterity varied by level. Activity performance and spontaneity of prosthetic use improved for users of the shoulder configuration level, while use of the prosthesis to perform activities and perceived difficulty performing self-selected tasks improved for all levels.

  13. Self-reported and performance-based outcomes using DEKA Arm.

    Science.gov (United States)

    Resnik, Linda; Borgia, Matthew; Latlief, Gail; Sasson, Nicole; Smurr-Walters, Lisa

    2014-01-01

    Mechanical properties of the DEKA Arm and associated engineering innovations are easy to observe. What is less clear is how these advances translate into functional benefits for the user with amputation. Study aims were to (1) quantify outcomes including dexterity, performance of daily activities, and prosthetic skill and spontaneity of users of the DEKA Arm and (2) compare outcomes when using the DEKA Arm with scores using the existing prosthesis. This was a quasi-experimental study. Descriptive analyses examined outcomes by DEKA Arm configuration level. Of the 39 subjects fit with a DEKA Arm, 32 were trained in use and completed end-of-study testing. Data from 26 prosthetic users were used to compare outcomes using existing prostheses with outcomes with the DEKA Arm. Dexterity and activity performance with the DEKA Arm varied by amputation level (p prosthetic use improved for users of the shoulder configuration level, while use of the prosthesis to perform activities and perceived difficulty performing self-selected tasks improved for all levels. PMID:25019659

  14. SOCS1 in cancer: An oncogene and a tumor suppressor.

    Science.gov (United States)

    Beaurivage, Claudia; Champagne, Audrey; Tobelaim, William S; Pomerleau, Véronique; Menendez, Alfredo; Saucier, Caroline

    2016-06-01

    The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. PMID:26811119

  15. Combinatorial Multi-Armed Bandit and Its Extension to Probabilistically Triggered Arms

    OpenAIRE

    Chen, Wei; Wang, Yajun; Yuan, Yang; Wang, Qinshi

    2014-01-01

    We define a general framework for a large class of combinatorial multi-armed bandit (CMAB) problems, where subsets of base arms with unknown distributions form super arms. In each round, a super arm is played and the base arms contained in the super arm are played and their outcomes are observed. We further consider the extension in which more based arms could be probabilistically triggered based on the outcomes of already triggered arms. The reward of the super arm depends on the outcomes of...

  16. Testing coordinate measuring arms with a geometric feature-based gauge: in situ field trials

    Science.gov (United States)

    Cuesta, E.; Alvarez, B. J.; Patiño, H.; Telenti, A.; Barreiro, J.

    2016-05-01

    This work describes in detail the definition of a procedure for calibrating and evaluating coordinate measuring arms (AACMMs or CMAs). CMAs are portable coordinate measuring machines that have been widely accepted in industry despite their sensitivity to the skill and experience of the operator in charge of the inspection task. The procedure proposed here is based on the use of a dimensional gauge that incorporates multiple geometric features, specifically designed for evaluating the measuring technique when CMAs are used, at company facilities (workshops or laboratories) and by the usual operators who handle these devices in their daily work. After establishing the procedure and manufacturing the feature-based gauge, the research project was complemented with diverse in situ field tests performed with the collaboration of companies that use these devices in their inspection tasks. Some of the results are presented here, not only comparing different operators but also comparing different companies. The knowledge extracted from these experiments has allowed the procedure to be validated, the defects of the methodologies currently used for in situ inspections to be detected, and substantial improvements for increasing the reliability of these portable instruments to be proposed.

  17. Testing coordinate measuring arms with a geometric feature-based gauge: in situ field trials

    International Nuclear Information System (INIS)

    This work describes in detail the definition of a procedure for calibrating and evaluating coordinate measuring arms (AACMMs or CMAs). CMAs are portable coordinate measuring machines that have been widely accepted in industry despite their sensitivity to the skill and experience of the operator in charge of the inspection task. The procedure proposed here is based on the use of a dimensional gauge that incorporates multiple geometric features, specifically designed for evaluating the measuring technique when CMAs are used, at company facilities (workshops or laboratories) and by the usual operators who handle these devices in their daily work. After establishing the procedure and manufacturing the feature-based gauge, the research project was complemented with diverse in situ field tests performed with the collaboration of companies that use these devices in their inspection tasks. Some of the results are presented here, not only comparing different operators but also comparing different companies. The knowledge extracted from these experiments has allowed the procedure to be validated, the defects of the methodologies currently used for in situ inspections to be detected, and substantial improvements for increasing the reliability of these portable instruments to be proposed. (paper)

  18. Are soils of Iowa USA currently a carbon sink or source? Simulated changes in SOC stock from 1972 to 2007

    Science.gov (United States)

    Liu, S.; Tan, Z.; Li, Z.; Zhao, S.; Yuan, W.

    2011-01-01

    Upscaling the spatial and temporal changes in carbon (C) stocks and fluxes from sites to regions is a critical and challenging step toward improving our understanding of the dynamics of C sources and sinks over large areas. This study simulated soil organic C (SOC) dynamics within 0-100cm depth of soils across the state of Iowa in the USA from 1972 to 2007 using the General Ensemble biogeochemical Modeling System (GEMS). The model outputs with variation coefficient were analyzed and assembled from simulation unit to the state scale based upon major land use types at annual step. Results from this study indicate that soils (within a depth of 0-100cm) in Iowa had been a SOC source at a rate of 190??380kg Cha-1yr-1. This was likely caused by the installation of a massive drainage system which led to the release of SOC from deep soil layers previously protected under poor drainage conditions. The annual crop rotation was another major force driving SOC variation and resulted in spatial variability of annual budgets in all croplands. Annual rate of change of SOC stocks in all land types depended significantly on the baseline SOC levels; soils with higher SOC levels tended to be C sources, and those with lower levels tended to be C sinks. Management practices (e.g., conservation tillage and residue management practices) slowed down the C emissions from Iowa soils, but could not reverse the general trend of net SOC loss in view of the entire state due mainly to a high level of baseline SOC stocks. ?? 2010 Elsevier B.V.

  19. Comparison of MODIS and VIIRS cloud properties with ARM ground-based observations over Finland

    Science.gov (United States)

    Sporre, Moa K.; O'Connor, Ewan J.; Håkansson, Nina; Thoss, Anke; Swietlicki, Erik; Petäjä, Tuukka

    2016-07-01

    Cloud retrievals from the Moderate Resolution Imaging Spectroradiometer (MODIS) instruments aboard the satellites Terra and Aqua and the Visible Infrared Imaging Radiometer Suite (VIIRS) instrument aboard the Suomi-NPP satellite are evaluated using a combination of ground-based instruments providing vertical profiles of clouds. The ground-based measurements are obtained from the Atmospheric Radiation Measurement (ARM) programme mobile facility, which was deployed in Hyytiälä, Finland, between February and September 2014 for the Biogenic Aerosols - Effects on Clouds and Climate (BAECC) campaign. The satellite cloud parameters cloud top height (CTH) and liquid water path (LWP) are compared with ground-based CTH obtained from a cloud mask created using lidar and radar data and LWP acquired from a multi-channel microwave radiometer. Clouds from all altitudes in the atmosphere are investigated. The clouds are diagnosed as single or multiple layer using the ground-based cloud mask. For single-layer clouds, satellites overestimated CTH by 326 m (14 %) on average. When including multilayer clouds, satellites underestimated CTH by on average 169 m (5.8 %). MODIS collection 6 overestimated LWP by on average 13 g m-2 (11 %). Interestingly, LWP for MODIS collection 5.1 is slightly overestimated by Aqua (4.56 %) but is underestimated by Terra (14.3 %). This underestimation may be attributed to a known issue with a drift in the reflectance bands of the MODIS instrument on Terra. This evaluation indicates that the satellite cloud parameters selected show reasonable agreement with their ground-based counterparts over Finland, with minimal influence from the large solar zenith angle experienced by the satellites in this high-latitude location.

  20. Different temporal bases for body and arm movements in volleyball serve reception.

    Science.gov (United States)

    Benerink, N H; Bootsma, R J; Zaal, F T J M

    2015-10-01

    In many sports, successfully intercepting a ball requires players to move both their body and their arms. Yet, studies of interception typically focus on one or the other. We performed an analysis of the moments of first foot and arm movements of elite-level volleyball players during serve reception. Video footage of five international matches of the Netherlands men's national volleyball team allowed the systematic coding and analysis of 347 different serve reception events. For each event, we identified the time of serve (TS) and time of contact (TC). Ball flight time (from TS to TC) varied between and within types of serve (power jump serves, n = 193, and jumping float serves, n = 154). Correlation analyses revealed that foot movement was initiated with respect to time from TS, while arm movement was initiated with respect to time until TC. These results suggest that whole-body and arm movements rely on different control processes. PMID:25622694

  1. BREST-1200 reactor fuel cycle based on the principles of nuclear arm non-proliferation and radiation-equivalent disposal of radioactive wastes

    International Nuclear Information System (INIS)

    The BREST-reactor fuel cycle, based on the principles of the nuclear arm non-proliferation and radiation-equivalent radioactive waste disposal, is described. The peculiarities of the BREST reactor, meeting the requirements of the nonproliferation of the nuclear materials, suitable for the nuclear arm production, are considered. The technological aspects of the fissile materials non-proliferation are discussed

  2. Sensor-based whole-arm obstacle avoidance utilizing ASIC technology

    International Nuclear Information System (INIS)

    Operation of manipulator systems in poorly defined work environments often presents a significant hazard to both the robotic assembly and the environment. In applications relating to the Environmental Restoration and Waste Management (ER ampersand WM) Program, many of the environments are considered hazardous, both, in the structure and composition of the environment Use of a sensing system that provides information to the manipulator control unit regarding obstacles in close proximity will provide protection against collisions. In this paper, a hierarchical design and implementation of a whole-arm obstacle avoidance system is presented. The system is based on capacitive sensors configured as bracelets for proximity sensing. Each bracelet contains a number of sensor nodes and a processor for sensor node control and readout, and communications with a higher level host, common to all bracelets. The host controls the entire sensing network and communicates proximity information to the manipulator controller. The overall architecture of this system is discussed with detail on the individual system modules. Details of an application specific integrated circuit (ASIC) designed to implement the sensor node electronics are presented. Justifications for the general measurement methods and associated implementation are discussed. Additionally, the current state of development including measured dam is presented

  3. Gesture Therapy: A Vision-Based System for Arm Rehabilitation after Stroke

    Science.gov (United States)

    Sucar, L. Enrique; Azcárate, Gildardo; Leder, Ron S.; Reinkensmeyer, David; Hernández, Jorge; Sanchez, Israel; Saucedo, Pedro

    Each year millions of people in the world survive a stroke, in the U.S. alone the figure is over 600,000 people per year. Movement impairments after stroke are typically treated with intensive, hands-on physical and occupational therapy for several weeks after the initial injury. However, due to economic pressures, stroke patients are receiving less therapy and going home sooner, so the potential benefit of the therapy is not completely realized. Thus, it is important to develop rehabilitation technology that allows individuals who had suffered a stroke to practice intensive movement training without the expense of an always-present therapist. Current solutions are too expensive, as they require a robotic system for rehabilitation. We have developed a low-cost, computer vision system that allows individuals with stroke to practice arm movement exercises at home or at the clinic, with periodic interactions with a therapist. The system integrates a web based virtual environment for facilitating repetitive movement training, with state-of-the art computer vision algorithms that track the hand of a patient and obtain its 3-D coordinates, using two inexpensive cameras and a conventional personal computer. An initial prototype of the system has been evaluated in a pilot clinical study with promising results.

  4. Integrated vision-based robotic arm interface for operators with upper limb mobility impairments.

    Science.gov (United States)

    Jiang, Hairong; Wachs, Juan P; Duerstock, Bradley S

    2013-06-01

    An integrated, computer vision-based system was developed to operate a commercial wheelchair-mounted robotic manipulator (WMRM). In this paper, a gesture recognition interface system developed specifically for individuals with upper-level spinal cord injuries (SCIs) was combined with object tracking and face recognition systems to be an efficient, hands-free WMRM controller. In this test system, two Kinect cameras were used synergistically to perform a variety of simple object retrieval tasks. One camera was used to interpret the hand gestures to send as commands to control the WMRM and locate the operator's face for object positioning. The other sensor was used to automatically recognize different daily living objects for test subjects to select. The gesture recognition interface incorporated hand detection, tracking and recognition algorithms to obtain a high recognition accuracy of 97.5% for an eight-gesture lexicon. An object recognition module employing Speeded Up Robust Features (SURF) algorithm was performed and recognition results were sent as a command for "coarse positioning" of the robotic arm near the selected daily living object. Automatic face detection was also provided as a shortcut for the subjects to position the objects to the face by using a WMRM. Completion time tasks were conducted to compare manual (gestures only) and semi-manual (gestures, automatic face detection and object recognition) WMRM control modes. The use of automatic face and object detection significantly increased the completion times for retrieving a variety of daily living objects. PMID:24187264

  5. Sequence and expression variation in SUPPRESSOR of OVEREXPRESSION of CONSTANS 1 (SOC1): homeolog evolution in Indian Brassicas.

    Science.gov (United States)

    Sri, Tanu; Mayee, Pratiksha; Singh, Anandita

    2015-09-01

    Whole genome sequence analyses allow unravelling such evolutionary consequences of meso-triplication event in Brassicaceae (∼14-20 million years ago (MYA)) as differential gene fractionation and diversification in homeologous sub-genomes. This study presents a simple gene-centric approach involving microsynteny and natural genetic variation analysis for understanding SUPPRESSOR of OVEREXPRESSION of CONSTANS 1 (SOC1) homeolog evolution in Brassica. Analysis of microsynteny in Brassica rapa homeologous regions containing SOC1 revealed differential gene fractionation correlating to reported fractionation status of sub-genomes of origin, viz. least fractionated (LF), moderately fractionated 1 (MF1) and most fractionated (MF2), respectively. Screening 18 cultivars of 6 Brassica species led to the identification of 8 genomic and 27 transcript variants of SOC1, including splice-forms. Co-occurrence of both interrupted and intronless SOC1 genes was detected in few Brassica species. In silico analysis characterised Brassica SOC1 as MADS intervening, K-box, C-terminal (MIKC(C)) transcription factor, with highly conserved MADS and I domains relative to K-box and C-terminal domain. Phylogenetic analyses and multiple sequence alignments depicting shared pattern of silent/non-silent mutations assigned Brassica SOC1 homologs into groups based on shared diploid base genome. In addition, a sub-genome structure in uncharacterised Brassica genomes was inferred. Expression analysis of putative MF2 and LF (Brassica diploid base genome A (AA)) sub-genome-specific SOC1 homeologs of Brassica juncea revealed near identical expression pattern. However, MF2-specific homeolog exhibited significantly higher expression implying regulatory diversification. In conclusion, evidence for polyploidy-induced sequence and regulatory evolution in Brassica SOC1 is being presented wherein differential homeolog expression is implied in functional diversification. PMID:26276216

  6. Realization of SOC behavior in a dc glow discharge plasma

    CERN Document Server

    Nurujjaman, M; Nurujjaman, Md.

    2006-01-01

    Experimental observations consistent with Self Organized Criticality (SOC) have been obtained in the electrostatic floating potential fluctuations of a dc glow discharge plasma. Power spectrum exhibits a power law which is compatible with the requirement for SOC systems. Also the estimated value of the Hurst exponent (self similarity parameter), H being greater than 0.5, along with an algebraic decay of the autocorrelation function, indicate the presence of temporal long-range correlations, as may be expected from SOC dynamics. This type of observations in our opinion has been reported for the first time in a glow discharge system.

  7. Implementation of a wireless ECG acquisition SoC for IEEE 802.15.4 (ZigBee) applications.

    Science.gov (United States)

    Wang, Liang-Hung; Chen, Tsung-Yen; Lin, Kuang-Hao; Fang, Qiang; Lee, Shuenn-Yuh

    2015-01-01

    This paper presents a wireless biosignal acquisition system-on-a-chip (WBSA-SoC) specialized for electrocardiogram (ECG) monitoring. The proposed system consists of three subsystems, namely, 1) the ECG acquisition node, 2) the protocol for standard IEEE 802.15.4 ZigBee system, and 3) the RF transmitter circuits. The ZigBee protocol is adopted for wireless communication to achieve high integration, applicability, and portability. A fully integrated CMOS RF front end containing a quadrature voltage-controlled oscillator and a 2.4-GHz low-IF (i.e., zero-IF) transmitter is employed to transmit ECG signals through wireless communication. The low-power WBSA-SoC is implemented by the TSMC 0.18-μm standard CMOS process. An ARM-based displayer with FPGA demodulation and an RF receiver with analog-to-digital mixed-mode circuits are constructed as verification platform to demonstrate the wireless ECG acquisition system. Measurement results on the human body show that the proposed SoC can effectively acquire ECG signals. PMID:25561447

  8. Effect of a mixed reality-based intervention on arm, hand, and finger function on chronic stroke

    OpenAIRE

    Colomer, Carolina; Llorens, Roberto; Noé, Enrique; Alcañiz, Mariano

    2016-01-01

    Background Virtual and mixed reality systems have been suggested to promote motor recovery after stroke. Basing on the existing evidence on motor learning, we have developed a portable and low-cost mixed reality tabletop system that transforms a conventional table in a virtual environment for upper limb rehabilitation. The system allows intensive and customized training of a wide range of arm, hand, and finger movements and enables interaction with tangible objects, while providing audiovisua...

  9. Single SOC Test Challenge for Blu-ray DVD

    Institute of Scientific and Technical Information of China (English)

    Don Blair; Keita Gunji

    2005-01-01

    The Blu-ray DVD single chip SOC architecture, challenging high speed and high fidelity mixed signal test requirements and test solutions are introduced. COT reductions to make this a mass production low cost test approach is also described.

  10. Dynamic Structure Optimization Design of Lower Control Arm Based on ESL

    Directory of Open Access Journals (Sweden)

    Lihui Zhao

    2012-11-01

    Full Text Available Structure optimization techniques under static load conditions have been widely used in automotive industry for lightweight and performance improvement of modern cars. However, these static load conditions could not represent all the severe situations of automobile parts which subjected to complex loads varying with time, especially for lower control arm of front suspension. In this study, dynamic optimization of lower control arm was performed by combing traditional static load optimization techniques and multi-body dynamics by Equivalent Static Load (ESL. And the best draw-bead distribution of the stamped lower control arm was attained. Comparing the MBD analysis results of the new design derived from dynamic optimization and original structure, results show that the strength and stiffness was increased significantly while the mass was almost unchanged.

  11. FXR induces SOCS3 and suppresses hepatocellular carcinoma

    OpenAIRE

    Guo, Fei; Xu, Zhizhen; Zhang, Yan; Jiang, Peng; Huang, Gang; Chen, Shan; Lyu, Xilin; Zheng, Ping; Zhao, Xin; Zeng, Yijun; Wang, Shuguang; He, Fengtian

    2015-01-01

    Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role in protecting against hepatocellular carcinoma (HCC). However, it is unclear whether the tumor suppressive activity of FXR involves the regulation of SOCS3. In the present study, we found that activation of FXR by its specific...

  12. Ion temperature in SOC and IOC discharges in ASDEX

    International Nuclear Information System (INIS)

    Active and passive charge exchange measurements were made to investigate the behaviour of the central ion temperature and the temperature profile for SOC and IOC discharges in ASDEX. Both methods show an increase in the central ion temperature during transition from SOC to IOC. Both methods also show a wider temperature profile for ions than for electrons. Peaking of the ion temperature profile during IOC cannot be definitely concluded from the measurements. (author) 7 refs., 4 figs

  13. Miscanthus-derived SOC: numerically declining over soil depths

    Science.gov (United States)

    Hu, Yaxian; Schäfer, Gerhard; Duplay, Joëlle; Kuhn, Nikolaus J.

    2016-04-01

    Miscanthus is one of the most efficient perennial bioenergy crops for wide establishment and distribution. Most of the previous reports had shown the benefits of Miscanthus cultivation in soil organic carbon (SOC) sequestration and greenhouse gas emissions (GHG) mitigation. However, some other papers pointed out that the Miscanthus-derived SOC is mainly of particulate organic matter and the labile quality of particulate organic matter may bear great uncertainties in GHGs emissions. This urges the necessity to investigate the quality and mineralization potential of Miscanthus-derived SOC. This study investigated soil profiles deep to 1 m from 20 yr Miscanthus fields in France and Switzerland. Soil organic carbon (SOC) concentration and δ13C compositions of all the soil layers (0-10, 10-40, 40-70 and 70-100 cm) were determined. Our results show that: 1) Miscanthus cultivation can in general increase the SOC stocks compared to the Grassland, while the benefits of SOC sequestration may only constrain to the surface soil. Isotopically, the Miscanthus-derived SOC ranged from 69% the top 10 cm soil down to only 7% in the 70 to 100 cm layer, cautioning the use of SOC stocks on the surface soil to estimate the total net benefits of Miscanthus cultivation in terms of sequestrating atmospheric CO2. 2) Compared to the Grassland soils, the surface soils on the Miscanthus fields tended to have a risk of acidification (pH values down to 6) and exceeded contents of P and K, adding another precaution to the environmental impacts of Miscanthus cultivation in the entire Upper Rhine Region. Overall, changes of soil characteristics must be included into Life Cycle Assessment to fully evaluate the environmental impacts of long-term Miscanthus cultivation.

  14. Real-Time Discrete Adaptive Control of Robot Arm Based on Digital Signal Processing

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A discrete model reference adaptive controller of robot arm is obtained by integrating the reduced dynamic model of robot, model reference adaptive control (MRAC) and digital signal processing (DSP) computer system into an electromechanical system. With the DSP computer system, the control signal of each joint of the robot arm can be processed in real time and independently. The simulation and experiment results show that with the control strategy, the robot achieved a good trajectory following precision, a good decoupling performance and a high real-time adaptivity.

  15. Robust EMG sensing system based on data fusion for myoelectric control of a robotic arm

    Directory of Open Access Journals (Sweden)

    Soria Carlos M

    2009-02-01

    Full Text Available Abstract Background Myoelectric control of a robotic manipulator may be disturbed by failures due to disconnected electrodes, interface impedance changes caused by movements, problems in the recording channel and other various noise sources. To correct these problems, this paper presents two fusing techniques, Variance Weighted Average (VWA and Decentralized Kalman Filter (DKF, both based on the myoelectric signal variance as selecting criterion. Methods Tested in five volunteers, a redundant arrangement was obtained with two pairs of electrodes for each recording channel. The myoelectric signals were electronically amplified, filtered and digitalized, while the processing, fusion algorithms and control were implemented in a personal computer under MATLAB® environment and in a Digital Signal Processor (DSP. The experiments used an industrial robotic manipulator BOSCH SR-800, type SCARA, with four degrees of freedom; however, only the first joint was used to move the end effector to a desired position, the latter obtained as proportional to the EMG amplitude. Results Several trials, including disconnecting and reconnecting one electrode and disturbing the signal with synthetic noise, were performed to test the fusion techniques. The results given by VWA and DKF were transformed into joint coordinates and used as command signals to the robotic arm. Even though the resultant signal was not exact, the failure was ignored and the joint reference signal never exceeded the workspace limits. Conclusion The fault robustness and safety characteristics of a myoelectric controlled manipulator system were substantially improved. The proposed scheme prevents potential risks for the operator, the equipment and the environment. Both algorithms showed efficient behavior. This outline could be applied to myoelectric control of prosthesis, or assistive manipulators to better assure the system functionality when electrode faults or noisy environment are present.

  16. Design of Programmable Automation Controller Based on ARM and Linux%基于ARM-Linux的可编程自动化控制器的设计

    Institute of Scientific and Technical Information of China (English)

    李斌; 陈富林; 李森; 王凯

    2011-01-01

    Based on the understanding of the PAC s function and programming method, a kind of PAC proto-type is discussed in detail. The main structure is introduced first, and later the operation system is deduced thor-oughly , both in hardware and software. Its hardware platform is based on a ARM board, while its software is based on linux as OS, Qt as HMI and Sqlite as database. Finally, analysis indicates that this PAC is of great scalability and portability, and can meet the industry requirements sufficiently.%在理解PAC系统的功能、组成和编程方法基础上,从整体上介绍了一种PAC的实现方案.首先对PAC总体结构作了简要介绍,然后主要对运行系统的整体构架的设计做了详细研究,包括软件及硬件系统的设计.运行系统的硬件平台是基于ARM的嵌入式控制器,软件方面使用linux作为操作系统,Qt作为界面,并支持Sqlite数据库.最后对软PLC系统的性能进行分析,分析结果表明:系统具备了良好的扩展性和移植性,达到了工业领域中的控制要求.

  17. Impact of vegetation types on soil organic carbon stocks SOC-S in Mediterranean natural areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Cantudo-Pérez, Marta

    2015-04-01

    Soils play a key role in the carbon geochemical cycle because they can either emit large quantities of CO2 or on the contrary they can act as a store for carbon. Agriculture and forestry are the only activities that can achieve this effect through photosynthesis and the carbon incorporation into carbohydrates (Parras-Alcántara et al., 2013). The Mediterranean evergreen oak Woodland (MEOW - dehesa) is a type of pasture with scattered evergreen and deciduous oak stands in which cereals are often grown under the tree cover. It is a system dedicated to the combined production of Iberian swine, sheep, fuel wood, coal and cork as well as to hunting. These semi-natural areas still preserve some of the primitive vegetation of the Mediterranean oak forests. The dehesa is a pasture where the herbaceous layer is comprised of either cultivated cereals such as oat, barley and wheat or native vegetation dominated by annual species, which are used as grazing resources. These Iberian open woodland rangelands (dehesas) have been studied from different points of view: hydrologically, with respect to soil organic matter content, as well as in relation to gully erosion, topographical thresholds, soil erosion and runoff production, soil degradation and management practices…etc, among others. The soil organic carbon stock capacity depends not only on abiotic factors such as the mineralogical composition and the climate, but also on soil use and management (Parras et al., 2014 and 2015). In Spanish soils, climate, use and management strongly affect the carbon variability, mainly in soils in dry Mediterranean climates characterized by low organic carbon content, weak structure and readily degradable soils. Hontoria et al. (2004) emphasized that the climate and soil use are two factors that greatly influence carbon content in the Mediterranean climate. This research sought to analyze the SOC stock (SOCS) variability in MEOW - dehesa with cereals, olive grove and Mediterranean oak forest

  18. Robotic arm

    Science.gov (United States)

    Kwech, Horst

    1989-04-18

    A robotic arm positionable within a nuclear vessel by access through a small diameter opening and having a mounting tube supported within the vessel and mounting a plurality of arm sections for movement lengthwise of the mounting tube as well as for movement out of a window provided in the wall of the mounting tube. An end effector, such as a grinding head or welding element, at an operating end of the robotic arm, can be located and operated within the nuclear vessel through movement derived from six different axes of motion provided by mounting and drive connections between arm sections of the robotic arm. The movements are achieved by operation of remotely-controllable servo motors, all of which are mounted at a control end of the robotic arm to be outside the nuclear vessel.

  19. Robotic arm

    International Nuclear Information System (INIS)

    A robotic arm positionable within a nuclear vessel by access through a small diameter opening and having a mounting tube supported within the vessel and mounting a plurality of arm sections for movement lengthwise of the mounting tube as well as for movement out of a window provided in the wall of the mounting tube is disclosed. An end effector, such as a grinding head or welding element, at an operating end of the robotic arm, can be located and operated within the nuclear vessel through movement derived from six different axes of motion provided by mounting and drive connections between arm sections of the robotic arm. The movements are achieved by operation of remotely-controllable servo motors, all of which are mounted at a control end of the robotic arm to be outside the nuclear vessel. 23 figs

  20. Refining regional SOC estimates: Accounting for erosion induced within field variability of the vertical distribution of SOC.

    Science.gov (United States)

    Meersmans, Jeroen; Quine, Tim

    2013-04-01

    Recently, soil organic carbon (SOC) is considered as a dynamic soil property largely influencing soil quality and global C-cycling. Consequently, accurate mapping of SOC at the regional or national scale becomes an important issue in order to help policymakers in developing an appropriate soil and climate change management strategy. So far, in these studies, only factors determining the spatial and temporal distribution of SOC at the landscape scale, such as soil type, land use (change), climate and agro-management, were considered. Despite the fact that a few recent studies incorporated as well the distribution of SOC with depth, resulting in an improved representation of the 3D distribution of SOC, most studies only considers topsoil and/or are characterized by simple sampling by site at rather coarse resolution. Consequently, they omit quantification of stable subsoil carbon buried in depositional areas and does not allow to clearly identify significant differences of SOC and erosion at the within field scale. Hence, the variability of SOC at smaller scales in complex terrain driven by lateral soil transport processes (such as soil erosion), is still rather understudied and is not (well) presented in existing regional SOC estimates. Nevertheless, incorporating this smaller level of spatial detail will most probably have a major influence on SOC mapping and regional SOC stock dynamics' calculations. Consequently, there exists an urgent need in conducting an appropriate soil sampling strategy considering deeper layers and enabling us to detect significant patterns at detailed spatial levels. In this study we aim to unravel the variation of SOC depth distributions along typical hillslope transects under cropland (Devon, UK) and link these to soil redistribution rates and variations in C input, i.e. below and above ground biomass productivity. The radionuclide isotope Caesium-137 (137Cs) was used as proxy for erosion. Furthermore, a soil sampling strategy was

  1. A New Crank Arm-Based Load Cell for the 3D Analysis of the Force Applied by a Cyclist

    Directory of Open Access Journals (Sweden)

    Alexandre Balbinot

    2014-12-01

    Full Text Available This report describes a new crank arm-based force platform designed to evaluate the three-dimensional force applied to the pedals by cyclists in real conditions. The force platform was designed to be fitted on a conventional competition bicycle crankset while data is transmitted wirelessly through a BluetoothTM module and also stored on a SD card. A 3D solid model is created in the SolidWorks (Dassault Systèmes SOLIDWORKS Corp. to analyze the static and dynamic characteristics of the crank arm by using the finite elements technique. Each crankset arm is used as a load cell based on strain gauges configured as three Wheatstone bridges. The signals are conditioned on a printed circuit board attached directly to the structure. The load cell showed a maximum nonlinearity error between 0.36% and 0.61% and a maximum uncertainty of 2.3% referred to the sensitivity of each channel. A roller trainer equipped with an optical encoder was also developed, allowing the measurement of the wheel’s instantaneous velocity.

  2. ARM Mentor Selection Process

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, D. L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-10-01

    The Atmospheric Radiation Measurement (ARM) Program was created in 1989 with funding from the U.S. Department of Energy (DOE) to develop several highly instrumented ground stations to study cloud formation processes and their influence on radiative transfer. In 2003, the ARM Program became a national scientific user facility, known as the ARM Climate Research Facility. This scientific infrastructure provides for fixed sites, mobile facilities, an aerial facility, and a data archive available for use by scientists worldwide through the ARM Climate Research Facility—a scientific user facility. The ARM Climate Research Facility currently operates more than 300 instrument systems that provide ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as lead mentors. Lead mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They must also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets. The ARM Climate Research Facility is seeking the best overall qualified candidate who can fulfill lead mentor requirements in a timely manner.

  3. Development of Stepper motor based Two DOF Robotic Arm Transferring Liquid using Peristaltic Pump

    Directory of Open Access Journals (Sweden)

    Padma Thiagarajan

    2013-02-01

    Full Text Available The aim of this work is to transfer liquid contents from one micro cell to another using two stepper motors and a peristaltic pump. There are two objectives here. One is to develop a low cost roboticarm using stepper motors. The second objective is the control and calibration of the peristaltic pump. All parts are controlled and operated by their respective microcontrollers. Fulfillment of both the objectives leads to an integrated system to transfer liquids from one cell to another. The end effecter of the robotic arm is connected to the peristaltic pump. The pump has two pipes connected to it. Through one pipe it takes in the liquid and through the other pipe it delivers the liquid into the second cell. After transferring one sample of liquid, the arm moves to a cleaning module where the end effecter is cleaned to avoid cross contamination. The robotic arm is built using stepper motors and controlled using Atmega32 microcontroller whereas the peristaltic pump is controlled and calibrated using 8051 microcontroller. The pumping is done with the help of DC motors. As a result, the working of the robotic arm and theperistaltic pump is verified experimentally.

  4. EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    V. V. Lim

    2014-01-01

    Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

  5. ARM for Platform Application

    Science.gov (United States)

    Patte, Mathieu; Poupat, Jean-Luc; Le Meur, Patrick

    2015-09-01

    The activities described in this paper are part of the CNES R&T “Study of a Cortex-R ARM based architecture” performed by Airbus DS Space System & Electronics in 2014. With the support of CNES, Airbus DS has performed the porting of a representative space application software on an ARM based demonstration platform. This paper presents the platform itself, the activities performed at software level and the first results on this evaluation study.

  6. Multi-arm multilateral haptics-based immersive tele-robotic system (HITS) for improvised explosive device disposal

    Science.gov (United States)

    Erickson, David; Lacheray, Hervé; Lai, Gilbert; Haddadi, Amir

    2014-06-01

    This paper presents the latest advancements of the Haptics-based Immersive Tele-robotic System (HITS) project, a next generation Improvised Explosive Device (IED) disposal (IEDD) robotic interface containing an immersive telepresence environment for a remotely-controlled three-articulated-robotic-arm system. While the haptic feedback enhances the operator's perception of the remote environment, a third teleoperated dexterous arm, equipped with multiple vision sensors and cameras, provides stereo vision with proper visual cues, and a 3D photo-realistic model of the potential IED. This decentralized system combines various capabilities including stable and scaled motion, singularity avoidance, cross-coupled hybrid control, active collision detection and avoidance, compliance control and constrained motion to provide a safe and intuitive control environment for the operators. Experimental results and validation of the current system are presented through various essential IEDD tasks. This project demonstrates that a two-armed anthropomorphic Explosive Ordnance Disposal (EOD) robot interface can achieve complex neutralization techniques against realistic IEDs without the operator approaching at any time.

  7. Optical Sensors Based on Single on Arm Thin Film Waveguide Interferometer

    Science.gov (United States)

    Sarkisov, S. S.; Diggs, D.; Curley, M.; Adamovsky, Grigory (Technical Monitor)

    2000-01-01

    Single-arm dual-mode optical waveguide interferometer utilizes interference between two modes of different order. Sensing effect results from the change in propagation conditions of the modes caused by the environment. The waveguide is made as an open asymmetric structure containing a dye-doped polymer film onto a quartz substrate. It is more sensitive to the change of environment than its conventional polarimetric analog using orthogonal modes (TE and TM) of the same order. The sensor still preserves the option of operating in polarimetric regime using a variety of mode combinations such as TE(sub 0)/TM(sub 0) (conventional) TE(sub 0)/TM(sub 1), TE(sub 1)/TM(sub 0), or TE(sub 1)/TM(sub 1) but can also work in nonpolarimetric regime using combinations TE(sub 0)/TE(sub 1) or TM(sub 0)/TM(sub 1). Utilization of different mode combinations simultaneously makes the device more versatile. Application of the sensor to gas sensing is based on doping polymer film with an organic indicator dye targeting a particular gaseous reagent. Change of the optical absorption spectrum of the dye caused by the gaseous pollutant results in change of the reactive index of the dye-doped polymer film that can be detected by the sensor. As indicator dyes we utilize Bromocresol Purple doped into polymer poly(methyl) methacrylate that is sensitive to small concentrations of ammonia. The indicator dye demonstrated an irreversible increase in optical absorption near the peak at 350 nm being exposed to 5% ammonia in pure nitrogen at 600 Torr. The dye also showed reversible growth of the absorption peak near 600 nm after exposure to a vapor of standard medical ammonia spirit (65% alcohol). We have built a breadboard prototype of the sensor with He-Ne laser as a light source and with a single mode fiber input and a multimode fiber output. The prototype showed a sensitivity to temperature change of the order of 2 C per 2pi phase shift. The sensitivity of the sensor to the presence of dTy ammonia is

  8. Robust torque control of an elastic robotic arm based on invertibility and feedback stabilization

    Science.gov (United States)

    Singh, S. N.; Schy, A. A.

    1985-01-01

    An approach to the control of elastic robotic systems for space applications using inversion, servocompensation, and feedback stabilization is presented. For simplicity, a robot arm (PUMA-type) with three rotational joints is considered. The third link is assumed to be elastic. Using an inversion algorithm, a nonlinear decoupling control law, u sub d, is derived such that in the closed loop system, independent control of joint angles by the three joint torquers is accomplished. For the stabilization of elastic oscillations, a linear feedback torquer control law, u sub s, is obtained applying linear quadratic optimization to the linearized arm model augmented with a servocompensator about the terminal state. Simulation results show that, in spite of uncertainties in the payload and vehicle angular velocity, good joint angle control and damping of elastic oscillations are obtained with the torquer control law u = u sub d + u sub s.

  9. A capacitance-based proximity sensor for whole arm obstacle avoidance

    International Nuclear Information System (INIS)

    This paper discusses an application of capacitive sensors for detecting incipient collisions during robot motion in unknown or partially modeled environments. Forty-five sensors capable of detecting obstacles up to 330 mm (13 in.) away were distributed over the surface of a PUMA 560 robot arm. Each sensor consisted of a 4 mm thick, 37 mm diameter rings around 21 mm diameter disks. These sensors can detect both conductive and non-conductive obstacles of arbitrary color and shape. The sensor hardware is reliable and inexpensive, and it may be fabricated using flexible printed circuit boards to provide whole-arm and joint protection for any robot or manipulator. Simple collision avoidance control algorithms that perturb the joint commands from a spaceball to avoid collisions have been implemented on the PUMA 560 robot

  10. Detachment of Tertiary Dendrite Arms during Controlled Directional Solidification in Aluminum - 7 wt Percent Silicon Alloys: Observations from Ground-based and Microgravity Processed Samples

    Science.gov (United States)

    Grugel, Richard N.; Erdman, Robert; Van Hoose, James R.; Tewari, Surendra; Poirier, David

    2012-01-01

    Electron Back Scattered Diffraction results from cross-sections of directionally solidified aluminum 7wt% silicon alloys unexpectedly revealed tertiary dendrite arms that were detached and mis-oriented from their parent arm. More surprisingly, the same phenomenon was observed in a sample similarly processed in the quiescent microgravity environment aboard the International Space Station (ISS) in support of the joint US-European MICAST investigation. The work presented here includes a brief introduction to MICAST and the directional solidification facilities, and their capabilities, available aboard the ISS. Results from the ground-based and microgravity processed samples are compared and possible mechanisms for the observed tertiary arm detachment are suggested.

  11. Design and implementation of a computer based site operations log for the ARM Program

    International Nuclear Information System (INIS)

    The Atmospheric Radiation Measurement (ARM) Program is a Department of Energy (DOE) research effort to reduce the uncertainties found in general circulation and other models due to the effects of clouds and solar radiation. ARM will provide an experimental testbed for the study of important atmospheric effects, particularly cloud and radiative processes, and testing of parameterizations of the processes for use in atmospheric models. The design of the testbed known as the Clouds and Radiation Testbed (CART), calls for five, long-term field data collection sites. The first site, located in the Southern Great Plains (SGP) in Lamont, OK began operation in the spring of 1992. The CART Data Environment (CDE) is the element of the testbed which acquires the basic observations from the instruments and processes them to meet the ARM requirements. A formal design was used to develop a description of the logical requirements for the CDE. This paper discusses the design and prototype implementation of a part of the CDE known as the site operations log, which records metadata defining the environment within which the data produced by the instruments is collected

  12. Selection of key terrain attributes for SOC model

    DEFF Research Database (Denmark)

    Greve, Mogens Humlekrog; Adhikari, Kabindra; Chellasamy, Menaka;

    As an important component of the global carbon pool, soil organic carbon (SOC) plays an important role in the global carbon cycle. SOC pool is the basic information to carry out global warming research, and needs to sustainable use of land resources. Digital terrain attributes are often use of...... predictors in Digital soil mapping of SOC. But there are no rules only few empirical guidelines on which digital terrain attributes to use. The aim of this paper was to select and the evaluate 21 digital terrain attributes and use the best for mapping. A typical 7500 km2 region located in Denmark was...... selected, total 2,514,820 data mining models were constructed by 71 differences grid from 12m to 2304m and 22 attributes, 21 attributes derived by DTM and the original elevation. Relative importance and usage of each attributes in every model were calculated. Comprehensive impact rates of each attribute...

  13. Architecture Design of Computing Intensive SoCs

    Institute of Scientific and Technical Information of China (English)

    YUE Yao; ZHANG Chunming; WANG Haixin; BAI Guoqiang; CHEN Hongyi

    2009-01-01

    Most existing system-on-chip (SoC) architectures are for microprocessor-centric designs. They are not suitable for computing intensive SoCs, which have their own configurability, extendibility, perform-ance, and data exchange characteristics. This paper analyzes these characteristics and gives design princi-ples for computing intensive SoCs. Three architectures suitable for different situations are compared with selection criteria given. The architectural design of a high performance network security accelerator (HPNSA) is used to elaborate on the design techniques to fully exploit the performance potential of the ar-chitectures. A behavior-level simulation system is implemented with the C++ programming language to evaluate the HPNSA performance and to obtain the optimum system design parameters. Simulations show that this architecture provides high performance data transfer.

  14. Possibility of Independence in ADL (Activities of Daily Living) for Patients with Cervical Spinal Cord Injuries : An Evaluation based on the Zancolli Classification of Residual Arm Functions

    OpenAIRE

    Yoshimura, Osamu; Takayanagi, Kiyomi; Kobayashi, Ryuji; Hosoda, Masataka; Minematsu, Akira; Sasaki, Hisato; Maejima, Hiroshi; Matsuda, Yuiti; Tanaka, Satiko; Matsuo, Akihisa; Kanemura, Naohiko

    1998-01-01

    For patients with cervical spinal cord injuries to become independent in their ADL (Activities of Daily Living), residual arm function is very important. Also, age, sex, physical strength, obesity, spasticity, pain, contracture and motivation are related. We investigated the possibility of independence in ADL for patients with cervical spinal cord injuries, carrying out our evaluation based on the Zancolli Classification of Residual Arm Functions. Zancolli classification C6BII is taken as the...

  15. A New Crank Arm-Based Load Cell for the 3D Analysis of the Force Applied by a Cyclist

    OpenAIRE

    Alexandre Balbinot; Cleiton Milani; Jussan da Silva Bahia Nascimento

    2014-01-01

    This report describes a new crank arm-based force platform designed to evaluate the three-dimensional force applied to the pedals by cyclists in real conditions. The force platform was designed to be fitted on a conventional competition bicycle crankset while data is transmitted wirelessly through a BluetoothTM module and also stored on a SD card. A 3D solid model is created in the SolidWorks (Dassault Systèmes SOLIDWORKS Corp.) to analyze the static and dynamic characteristics of the crank a...

  16. Sensor-based whole-arm obstacle avoidance for unstructured environments

    International Nuclear Information System (INIS)

    Whole-arm obstacle avoidance is needed for a variety of robotic applications in the Environmental Restoration and Waste Management (ER ampersand WM) Program. Typical industrial applications of robotics involve well-defined workspaces, allowing a predetermined knowledge of collision-free paths for manipulator motion. However, many hazardous environments are unstructured or poorly defined, providing a significant potential for collisions between manipulators and the environment. In order to allow applications of robotics in such situations, a sensing system is under development which will provide protection against collisions. Specifics of this system including system architecture and projected implementation are described

  17. The Design of a Small UAV's Flight Controller Based on ARM11+CPLD%基于ARM11+CPLD的小型无人机飞行控制器设计

    Institute of Scientific and Technical Information of China (English)

    郑积仕; 蒋新华; 陈兴武

    2012-01-01

    本文针对小型无人机控制精度低、实时性不足的问题,设计了基于ARM11+ CPLD的飞行控制器.阐述该飞行控制器的硬件总体架构,各传感器与ARM11接口设计,CPLD并行多路PWM输入、输出设计;阐述硬件的驱动,导航控制、姿态控制的算法设计与实现.该飞行控制器的飞行测试结果理想.%The design of the flight controller based on ARM11+CPLD is presented in this paper aiming to solve the low accuracy and the inadequacy of real time in the control of UAV (Unamed Aircraft Veheicle). The overall frame of the flight controller hardware, the design of the interface between ARM11 and several sensors and the design of multi parallel PWM controls in CPLD are all presented. Furthermore, this paper also elaborates the hardware drive and the algorithm design and fulfillment of the navigation control and the attitude control. The flight test shows the flight controller works well.

  18. Correct-by-construction approaches for SoC design

    CERN Document Server

    Sinha, Roopak; Basu, Samik

    2013-01-01

    This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

  19. Does density fractionation of SOC represent chemically different carbon pools?

    OpenAIRE

    Mulvaney, Michael J.; Graham, M.; Xia, K.; Barrera, Victor H.; Botello, Rubén; Saavedra, Ana Karina; Mamani, P.

    2012-01-01

    Organic matter stabilization is thought to be a process of physical protection and chemical recalcitrance. The determination of recalcitrant soil organic carbon (SOC) often relies on operational definitions provided by various fractionation techniques, usually particle size or density fractionation. However, it is unknown if these operational definitions represent true chemical recalcitrance.

  20. Automatic standard plane adjustment on mobile C-Arm CT images of the calcaneus using atlas-based feature registration

    Science.gov (United States)

    Brehler, Michael; Görres, Joseph; Wolf, Ivo; Franke, Jochen; von Recum, Jan; Grützner, Paul A.; Meinzer, Hans-Peter; Nabers, Diana

    2014-03-01

    Intraarticular fractures of the calcaneus are routinely treated by open reduction and internal fixation followed by intraoperative imaging to validate the repositioning of bone fragments. C-Arm CT offers surgeons the possibility to directly verify the alignment of the fracture parts in 3D. Although the device provides more mobility, there is no sufficient information about the device-to-patient orientation for standard plane reconstruction. Hence, physicians have to manually align the image planes in a position that intersects with the articular surfaces. This can be a time-consuming step and imprecise adjustments lead to diagnostic errors. We address this issue by introducing novel semi-/automatic methods for adjustment of the standard planes on mobile C-Arm CT images. With the semi-automatic method, physicians can quickly adjust the planes by setting six points based on anatomical landmarks. The automatic method reconstructs the standard planes in two steps, first SURF keypoints (2D and newly introduced pseudo-3D) are generated for each image slice; secondly, these features are registered to an atlas point set and the parameters of the image planes are transformed accordingly. The accuracy of our method was evaluated on 51 mobile C-Arm CT images from clinical routine with manually adjusted standard planes by three physicians of different expertise. The average time of the experts (46s) deviated from the intermediate user (55s) by 9 seconds. By applying 2D SURF key points 88% of the articular surfaces were intersected correctly by the transformed standard planes with a calculation time of 10 seconds. The pseudo-3D features performed even better with 91% and 8 seconds.

  1. Human Arm Motion Tracking by Orientation-Based Fusion of Inertial Sensors and Kinect Using Unscented Kalman Filter.

    Science.gov (United States)

    Atrsaei, Arash; Salarieh, Hassan; Alasty, Aria

    2016-09-01

    Due to various applications of human motion capture techniques, developing low-cost methods that would be applicable in nonlaboratory environments is under consideration. MEMS inertial sensors and Kinect are two low-cost devices that can be utilized in home-based motion capture systems, e.g., home-based rehabilitation. In this work, an unscented Kalman filter approach was developed based on the complementary properties of Kinect and the inertial sensors to fuse the orientation data of these two devices for human arm motion tracking during both stationary shoulder joint position and human body movement. A new measurement model of the fusion algorithm was obtained that can compensate for the inertial sensors drift problem in high dynamic motions and also joints occlusion in Kinect. The efficiency of the proposed algorithm was evaluated by an optical motion tracker system. The errors were reduced by almost 50% compared to cases when either inertial sensor or Kinect measurements were utilized. PMID:27428461

  2. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

    Directory of Open Access Journals (Sweden)

    Eva-K Pauli

    2008-11-01

    Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

  3. Identification of RBC and WBC Count in Human Blood Using ARM Based Instrumentation

    Directory of Open Access Journals (Sweden)

    B.Dodda Basavanagoud

    2015-06-01

    Full Text Available The rapid growth in microelectronics and crunching RISC in the field of bio-medical sciences incorporated of soft tools to diagnose various parameters of human fluids. Conventional method of blood sample analysis makes use of laboratory technique of titration, which is operator-dependent and results in lot of errors depending on the skill of the technician. In order to eliminate the human errors involved in the conventional method, in this paper an attempt has been made to present a capillary centrifuge technique driven by high speed DC motor fed by Morgan chopper and controlled by powerful ARM processor. It results in accurate analysis of the blood samples. The various techniques involved in accurate sensing of speed using timer and generation of firing pulses to thyristor in the Morgan chopper is judiciously achieved. This paper clearly brings out the advantages of the proposed blood measurement technique which effectively gives blood analysis faster and at a low cost.

  4. Driving and controlling circuit for full-color OLED based on ARM7%ARM7全彩OLED驱动控制电路设计

    Institute of Scientific and Technical Information of China (English)

    张翔; 蒋泉

    2012-01-01

    介绍了一款全彩无源OLED模块的驱动接口电路及驱动程序的设计.系统采用ARM7系列的LPC2138为控制核心,分别设计了电源电路、下载电路、复位电路和接口电路,并向全彩无源OLED模块提供数据信号和控制信号,从而实现了分辨力为128×128,65×103色的动态全彩图片显示.设计了基于ARM7内核的OLED驱动电路实验系统,可显示红、绿、蓝单色以及全彩图片,为中小尺寸OLED提供了一种低成本、低功耗的单芯片解决方案.%The paper introduces the design of driving circuit, reset circuit, download circuit, interface circuit and driving programs of the full-color passive OLED(organic light emitting device) module in the display system. The system adopts the LPC2138, family of ARM7-core, to control the OLED module. The data and control signals are provided by LPC2138 in order to realize a resolution of 128X 128, 65X 103 dynamic full-color display. Experiment results show that the system can display red, green, blue and full-color pictures, provide a low-cost, low-power and single-chip solution for small sized OLEDs.

  5. Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector

    International Nuclear Information System (INIS)

    CML28 is an attractive target for antigen-specific immunotherapy. SOCS1 represents an inhibitory control mechanism for DC antigen presentation and the magnitude of adaptive immunity. In this study, we evaluated the potential for inducing CML28-specific cytotoxic T lymphocytes (CTL) responses by dendritic cells (DCs)-based vaccination. We constructed a CML28 DNA vaccine and a SOCS1 siRNA vector and then cotransfect monocyte-derived DCs. Flow cytometry analysis showed gene silencing of SOCS1 resulted in higher expressions of costimulative moleculars in DCs. Mixed lymphocyte reaction (MLR) indicated downregulation of SOCS1 stronger capability to stimulate proliferation of responder cell in DCs. The CTL assay revealed transfected DCs effectively induced autologous CML28-specific CTL responses and the lytic activities induced by SOCS1-silenced DCs were significantly higher compared with those induced by SOCS1-expressing DCs. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs

  6. A Cryptographic SoC for Robust Protection of Secret Keys in IPTV DRM Systems

    Science.gov (United States)

    Lee, Sanghan; Yang, Hae-Yong; Yeom, Yongjin; Park, Jongsik

    The security level of an internet protocol television (IPTV) digital right management (DRM) system ultimately relies on protection of secret keys. Well known devices for the key protection include smartcards and battery backup SRAMs (BB-SRAMs); however, these devices could be vulnerable to various physical attacks. In this paper, we propose a secure and cost-effective design of a cryptographic system on chip (SoC) that integrates the BB-SRAM with a cell-based design technique. The proposed SoC provides robust safeguard against the physical attacks, and satisfies high-speed and low-price requirements of IPTV set-top boxes. Our implementation results show that the maximum encryption rate of the SoC is 633Mb/s. In order to verify the data retention capabilities, we made a prototype chip using 0.18µm standard cell technology. The experimental results show that the integrated BB-SRAM can reliably retain data with a 1.4µA leakage current.

  7. Coordinating a Service Supply Chain under Arms Offset Program’s Intervention by Performance-Based Contracting

    Directory of Open Access Journals (Sweden)

    Yi-Kuei Lin

    2016-01-01

    Full Text Available This paper investigates a support service supply chain for coordinating with a local third-party logistics provider by arms offset program’s intervention and develops a performance-based contracting framework for the coordinating problem, which remains scarce in the literatures. The performance-based contracting framework evaluates payments and profits for the support service by a game-theoretical approach with principal-agent model. We prove that the proposed framework is an effective tool in acquiring the balance between maximum profit and minimum payment for both parties in the coordinating problem without moral hazard issue. A numerical study consolidates the formulated schemes as contracting preference for both parties’ decision with a higher profit margin at a lower customer’s payment.

  8. Design of image interaction and display system based on ARM+FPGA%基于 ARM+FPGA 的影像交互与显示系统设计

    Institute of Scientific and Technical Information of China (English)

    吴迪; 李丙玉; 王晓东

    2015-01-01

    To promote the integration of mapping information obtained,image interaction and display are realized based on the dual-core ARM+FPGA hardware architecture in this paper by taking full ad-vantage of the parallel processor FPGA (Field-Programmable Gate Array)and the high-performance ARM processor.The real-time image display is realized based on Qt graphical interface and the driven design of FPGA FIFO (First Input First Output)is completed in the Linux 2.6.36 kernel which uses Linux operating system as the software platform,ARM1 1 as the core of embedded hardware processor and FPGA as the coprocessor.The test results show that it could achieve high speed VGA (640×480) format image interaction between ARM and FPGA with the maximum frame rate of 26 fps and the maximum transmission bandwidth of 182 Mbps.This system not only has the advantages of small vol-ume, low power consumption, low cost, but also has good performance of stability and functionality.Moreover,it could meet the real-time requirements for the aerial remote sensing system.%为促进航空测绘信息获取的数字化、一体化、实时化,本文利用 FPGA(Field-Programmable Gate Array,即现场可编程门阵列)并行处理的优势结合 ARM 处理器低功耗高性能的特点,基于 ARM+FPGA 的双核硬件架构实现了影像的交互与显示。该系统以 Linux 操作系统为软件开发平台,以 ARM11嵌入式处理器为硬件核心、FPGA 作为协处理器,采用 FPGA 片内 FIFO(First Input First Output,即先进先出存储器)作为 ARM 处理器与 FPGA 之间的高速通信桥梁,针对 Linux 2.6.36内核完成了对 FPGA 设备的驱动设计,并基于 Qt 图形用户界面实现了影像的实时显示。测试结果表明,ARM 处理器与 FPGA 之间能够实现 VGA(640×480)图像的高速交互,帧率可达26帧/s,最大传输带宽为182 Mbps。该系统不仅体积小、功耗低、成本低,而且稳定性好、功能强,能够满足航空遥感摄影系统的实时性要求。

  9. Surgical Simulations Based on Limited Quantitative Data: Understanding How Musculoskeletal Models Can Be Used to Predict Moment Arms and Guide Experimental Design.

    Science.gov (United States)

    Nichols, Jennifer A; Bednar, Michael S; Murray, Wendy M

    2016-01-01

    The utility of biomechanical models and simulations to examine clinical problems is currently limited by the need for extensive amounts of experimental data describing how a given procedure or disease affects the musculoskeletal system. Methods capable of predicting how individual biomechanical parameters are altered by surgery are necessary for the efficient development of surgical simulations. In this study, we evaluate to what extent models based on limited amounts of quantitative data can be used to predict how surgery influences muscle moment arms, a critical parameter that defines how muscle force is transformed into joint torque. We specifically examine proximal row carpectomy and scaphoid-excision four-corner fusion, two common surgeries to treat wrist osteoarthritis. Using models of these surgeries, which are based on limited data and many assumptions, we perform simulations to formulate a hypothesis regarding how these wrist surgeries influence muscle moment arms. Importantly, the hypothesis is based on analysis of only the primary wrist muscles. We then test the simulation-based hypothesis using a cadaveric experiment that measures moment arms of both the primary wrist and extrinsic thumb muscles. The measured moment arms of the primary wrist muscles are used to verify the hypothesis, while those of the extrinsic thumb muscles are used as cross-validation to test whether the hypothesis is generalizable. The moment arms estimated by the models and measured in the cadaveric experiment both indicate that a critical difference between the surgeries is how they alter radial-ulnar deviation versus flexion-extension moment arms at the wrist. Thus, our results demonstrate that models based on limited quantitative data can provide novel insights. This work also highlights that synergistically utilizing simulation and experimental methods can aid the design of experiments and make it possible to test the predictive limits of current computer simulation techniques

  10. Fractal Characteristics of Gravity Landform and Its SOC Mechanism

    Institute of Scientific and Technical Information of China (English)

    YAO Lingkan; QI Ying

    2007-01-01

    From the principle of self-organized criticality (SOC), this work presents our current understanding of the relationship between the morphology and the dynamics of the evolution of landforms. First, we validate the assumption: Erosional slopes may be treated as SOC systems. Thus Sand-pile models will reflect the universal process of energy dissipation within the slope accumulation under the self-organizing actions. And the scale and frequency of deposit landforms will be related by Fractal structure. Then, by analyzing the field data, such as landslides, rockfalls and debris flow fans, hi three typical areas, the power law for the magnitude-frequency seems very robust. Furthermore, some problems in application are discussed.

  11. SOCS1 and Regulation of Regulatory T Cells Plasticity

    Directory of Open Access Journals (Sweden)

    Reiko Takahashi

    2014-01-01

    Full Text Available Several reports have suggested that natural regulatory T cells (Tregs lose Forkhead box P3 (Foxp3 expression and suppression activity under certain inflammatory conditions. Treg plasticity has been studied because it may be associated with the pathogenesis of autoimmunity. Some studies showed that a minor uncommitted Foxp3+ T cell population, which lacks hypomethylation at Treg-specific demethylation regions (TSDRs, may convert to effector/helper T cells. Suppressor of cytokine signaling 1 (SOCS1, a negative regulator of cytokine signaling, has been reported to play an important role in Treg cell integrity and function by protecting the cells from excessive inflammatory cytokines. In this review, we discuss Treg plasticity and maintenance of suppression functions in both physiological and pathological settings. In addition, we discuss molecular mechanisms of maintaining Treg plasticity by SOCS1 and other molecules. Such information will be useful for therapy of autoimmune diseases and reinforcement of antitumor immunity.

  12. A new concept of feature-based gauge for coordinate measuring arm evaluation

    International Nuclear Information System (INIS)

    Articulated arm coordinate measuring machines (AACMM or CMA) have conquered a market share in the actual dimensional metrology field, overall when their role implies the inspection of geometrical and dimensional tolerances in an accurate 3D environment for medium-size parts. However, the unavoidable fact of AACMM manual operation constrains its reliability to a great extent, avoiding rigorous evaluation and casting doubt upon the usefulness of external calibration. In this research, a dimensional gauge especially aimed at AACMM evaluation has been developed. Furthermore, the operator skill will be revealed through the use of this gauge. A set of geometrical features, some of them oriented to evaluate the operator and others the equipment, have been collected for the gauge. The proposed evaluation methodology clearly distinguishes between dimensional and geometrical tolerances (with or without datum references), whereas actual verification standards only consider the former. Next, quality indicators deduced from the measurement results are proposed in order to compare AACMM versus coordinate measuring machine (CMM) performance, assuming that CMM possess the maximum accuracy that AACMM could reach, because CMM combines maximum contact accuracy with minimum operator influence. As a result, AACMM evaluation time could be significantly reduced since this gauge allows us to perform a customized evaluation of only those specific tolerances of interest to the user. (paper)

  13. Mid-upper Arm Circumference Based Undernutrition among Bengalee Children of Chapra, West Bengal, India

    Directory of Open Access Journals (Sweden)

    Sadaruddin Biswas

    2010-03-01

    Full Text Available Objective:To investigate age and sex variations in undernutrition using mid-upper arm circumference (MUAC cut-off values among 2016 (930 boys and 1086 girls. 3-5 years old rural children of Bengalee ethnicity at 66 Integrated Child Development Services (ICDS Centers of Nadia District, West Bengal, India.Methods:In a cross sectional study in west Bengal of India, MUAC was measured using standard technique. A total of 2028 children (935 boys and 1093 girls from 66 ICDS centers were enrolled in this study. The response rate was approximately 95%.Findings:Mean MUAC among boys was higher than girls at all ages except 5 years. Significant sex differences were not observed over ages. The age-combined rates of overall (moderate and severe undernutrition among boys (38.49% was higher than among girls (32.22%.The age-combined rates of moderate undernutrition were 36.34% and 31.03% among boys and girls, respectively. The rates of severe undernutrition were 2.15% and 1.20% among boys and girls, respectively. There were sex differences in both moderate and severe undernutrition. In general, there was an increasing trend in the rates of overall undernutrition from 3 to 5 years in both sexes.Conclusion:These children were experiencing severe nutritional stress.

  14. Mid-Upper Arm Circumference Based Undernutrition Among Bengalee Children of Chapra, West Bengal, India

    Directory of Open Access Journals (Sweden)

    Ashish Mukhopadhyay

    2010-03-01

    Full Text Available Objective:To investigate age and sex variations in undernutrition using mid-upper arm circumference (MUAC cut-off values among 2016 (930 boys and 1086 girls. 3-5 years old rural children of Bengalee ethnicity at 66 Integrated Child Development Services (ICDS Centers of Nadia District, West Bengal, India. Methods:In a cross sectional study in west Bengal of India, MUAC was measured using standard technique. A total of 2028 children (935 boys and 1093 girls from 66 ICDS centers were enrolled in this study. The response rate was approximately 95%. Findings:Mean MUAC among boys was higher than girls at all ages except 5 years. Significant sex differences were not observed over ages. The age-combined rates of overall (moderate and severe undernutrition among boys (38.49% was higher than among girls (32.22%.The age-combined rates of moderate undernutrition were 36.34% and 31.03% among boys and girls, respectively. The rates of severe undernutrition were 2.15% and 1.20% among boys and girls, respectively. There were sex differences in both moderate and severe undernutrition. In general, there was an increasing trend in the rates of overall undernutrition from 3 to 5 years in both sexes. Conclusion:These children were experiencing severe nutritional stress.

  15. SOC 331 ash course tutorial/tutorial rank

    OpenAIRE

    dgyui

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 6 Times, Rating: A   SOC 331 Complete Course (Not final paper) Sociology - General Sociology Moral, Legal, and Religious Perspectives on Social Justice. In Chapter 1 of your textbook, justice is analyzed from three perspectives, each with its own set of relevant concepts. The text includes three case studies for consideration from each perspective. Select one (only one) of these case studies...

  16. 基于ARM_Linux的次声数据采集系统%Infrasound Data Acquisition System Based on ARM and Embedded Linux

    Institute of Scientific and Technical Information of China (English)

    范春凤; 梁伟; 张来斌

    2010-01-01

    提出了一种基于ARM9和嵌入式Linux的次声数据采集系统的设计方案.采用以ATMELAT91SAM9263微处理器和LatticeXP2系列FPGA为核心的架构,基于双扭环技术、套接字编程等实现了高速多通道数据采集、高精度数据采集、海量存储、远程传输等功能,已经在管道泄漏次声测试实验中投入使用.

  17. Robot arm based flat panel CT-guided electromagnetic tracked spine interventions: phantom and animal model experiments

    Energy Technology Data Exchange (ETDEWEB)

    Penzkofer, Tobias; Isfort, Peter; Bruners, Philipp; Mahnken, Andreas H. [RWTH Aachen University, Applied Medical Engineering, Helmholtz-Institute Aachen, Aachen (Germany); RWTH Aachen University, Department of Diagnostic Radiology, Aachen University Hospital, Aachen (Germany); Wiemann, Christian; Guenther, Rolf W. [RWTH Aachen University, Department of Diagnostic Radiology, Aachen University Hospital, Aachen (Germany); Kyriakou, Yiannis; Kalender, Willi A. [Friedrich-Alexander University of Erlangen-Nuremberg, Institute for Medical Physics, Erlangen (Germany); Schmitz-Rode, Thomas [RWTH Aachen University, Applied Medical Engineering, Helmholtz-Institute Aachen, Aachen (Germany)

    2010-11-15

    To evaluate accuracy and procedure times of electromagnetic tracking (EMT) in a robotic arm mounted flat panel setting using phantom and animal cadaveric models. A robotic arm mounted flat panel (RMFP) was used in combination with EMT to perform anthropomorphic phantom (n = 90) and ex vivo pig based punctures (n = 120) of lumbar facet joints (FJ, n = 120) and intervertebral discs (IVD, n = 90). Procedure accuracies and times were assessed and evaluated. FJ punctures were carried out with a spatial accuracy of 0.8 {+-} 0.9 mm (phantom) and 0.6 {+-} 0.8 mm (ex vivo) respectively. While IVD punctures showed puncture deviations of 0.6 {+-} 1.2 mm (phantom) and 0.5 {+-} 0.6 mm (ex vivo), direct and angulated phantom based punctures had accuracies of 0.8 {+-} 0.9 mm and 1.0 {+-} 1.3 mm. Planning took longer for ex vivo IVD punctures compared to phantom model interventions (39.3 {+-} 17.3 s vs. 20.8 {+-} 5.0 s, p = 0.001) and for angulated vs. direct phantom FJ punctures (19.7 {+-} 5.1 s vs. 28.6 {+-} 7.8 s, p < 0.001). Puncture times were longer for ex vivo procedures when compared to phantom model procedures in both FJ (37.9 {+-} 9.0 s vs. 23.6 {+-} 7.2 s, p = 0.001) and IVD punctures (43.9 {+-} 16.1 s vs. 31.1 {+-} 6.4 s, p = 0.026). The combination of RMFP with EMT provides an accurate method of navigation for spinal interventions such as facet joint punctures and intervertebral disc punctures. (orig.)

  18. Study on the expression of SOCS-1 SOCS-3 in liver and spleen of mice induced by acute organophosphorus pesticide poisoning( AOPP)%SOCS-1 SOCS-3在有机磷中毒鼠肝脾中表达的研究

    Institute of Scientific and Technical Information of China (English)

    欧阳艳红; 李松玲; 宋维; 赵宁; 马中富

    2009-01-01

    S-3水平均升高, 与对照组比较差异有统计学意义(P<0.05).统计分析显示, 肝脏中SOCS-1和SOCS-3 mRNA明显正相关(r=0.922,P<0.01) ,脾脏中SOCS-1和SOCS-3 mRNA明显正相关(r=0.957,P<0.01).结论 AOPP可诱导SOCS-1、SOCS-3在肝脾中表达,不同时间点AOPP中毒小鼠肝脏、脾脏中SOCS-1、SOCS-3 mRNA表达升高趋势一致.

  19. SOCS-1 deficiency does not prevent diet-induced insulin resistance

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie;

    2008-01-01

    Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we...... investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression...... of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency...

  20. Online cell SOC estimation of Li-ion battery packs using a dual time-scale Kalman filtering for EV applications

    International Nuclear Information System (INIS)

    Highlights: ► We use an equivalent circuit model to describe the characteristics of battery. ► A dual time-scale estimator is used to calculate pack average SOC and cell SOC. ► The estimator is based on the dynamic descriptions and extended Kalman filter. ► Three different test cases are designed to validate the proposed method. ► Test results indicate a good performance of the method for EV applications. -- Abstract: For the vehicular operation, due to the voltage and power/energy requirements, the battery systems are usually composed of up to hundreds of cells connected in series or parallel. To accommodate the operation conditions, the battery management system (BMS) should estimate State of Charge (SOC) to facilitate safe and efficient utilization of the battery. The performance difference among the cells makes a pure pack SOC estimation hardly provide sufficient information, which at last affects the computation of available energy and power and the safety of the battery system. So for a reliable and accurate management, the BMS should “know” the SOC of each individual cell. Several possible solutions on this issue have been reported in the recent years. This paper studies a method to determine online all individual cell SOCs of a series-connected battery pack. This method, with an equivalent circuit based “averaged cell” model, estimates the battery pack’s average SOC first, and then incorporates the performance divergences between the “averaged cell” and each individual cell to generate the SOC estimations for all cells. This method is developed based on extended Kalman filter (EKF), and to reduce the computation cost, a dual time-scale implementation is designed. The method is validated using results obtained from the measurements of a Li-ion battery pack under three different tests, and analysis indicates the good performance of the algorithm.

  1. A new geometric-based model to accurately estimate arm and leg inertial estimates.

    Science.gov (United States)

    Wicke, Jason; Dumas, Geneviève A

    2014-06-01

    Segment estimates of mass, center of mass and moment of inertia are required input parameters to analyze the forces and moments acting across the joints. The objectives of this study were to propose a new geometric model for limb segments, to evaluate it against criterion values obtained from DXA, and to compare its performance to five other popular models. Twenty five female and 24 male college students participated in the study. For the criterion measures, the participants underwent a whole body DXA scan, and estimates for segment mass, center of mass location, and moment of inertia (frontal plane) were directly computed from the DXA mass units. For the new model, the volume was determined from two standing frontal and sagittal photographs. Each segment was modeled as a stack of slices, the sections of which were ellipses if they are not adjoining another segment and sectioned ellipses if they were adjoining another segment (e.g. upper arm and trunk). Length of axes of the ellipses was obtained from the photographs. In addition, a sex-specific, non-uniform density function was developed for each segment. A series of anthropometric measurements were also taken by directly following the definitions provided of the different body segment models tested, and the same parameters determined for each model. Comparison of models showed that estimates from the new model were consistently closer to the DXA criterion than those from the other models, with an error of less than 5% for mass and moment of inertia and less than about 6% for center of mass location. PMID:24735506

  2. 基于ARM的微型打印机研究与设计%The Research and Design for Micro-Printer Based on ARM

    Institute of Scientific and Technical Information of China (English)

    冯艳娜

    2011-01-01

    With economic development, improvement of living standards of people, the requirement of micro-printer is increasing.Usually, the micro-printer clip is controlled by single-chip. As a result of single-chip's performance limitations, embedded ARM has gradually replaced it. Account of the cost, performance, power consumption, security and other aspects, using of ARM to control micro-printer clip is a good choice. This paper introduces a micro-printer based on ARM which controls the M- 15011 printer core by ARM7 S3C44B0X.%随着经济的发展和人们生活水平的提高,行业用户对于微型打印机的需求不断增长.微型打印机多由单片机控制,由于单片机性能所限,考虑成本、性能,功耗、安全等各方面的话,采用ARM主板是很不错的选择.本文介绍了基于ARM的微机打印机的硬件、软件设计与实现.系统采用ARM7 S3C44BOX芯片控制EPSON公司M-150Ⅱ型打印机芯实现了微型打印功能.

  3. SOCS1 und SOCS3 mRNA Expression im Blut im Kontext der perioperativen Immunantwort bei offenen abdominal-chirurgischen Eingriffen

    OpenAIRE

    Schubert, Theresa

    2016-01-01

    Introduction: Each surgery causes a response of the immune system characterized by a complex interaction of cellular and humoral factors. The regulation of these factors is highly significant. An excessive or insufficient immune response can be fatal. SOCS proteins are important regulators of the cytokine signalling. The aim of the present study was to clarify if SOCS1 and SOCS3 are induced in cells of the blood during the perioperative period and whether these changes in expression cor...

  4. NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

    DEFF Research Database (Denmark)

    Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra;

    Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...

  5. DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

  6. An embedded real-time red peach detection system based on an OV7670 camera, ARM Cortex-M4 processor and 3D Look-Up Tables

    OpenAIRE

    Marcel Tresanchez; Miquel Nogués; Tomàs Pallejà; Davinia Font; Mercè Teixidó; Jordi Palacín

    2012-01-01

    This work proposes the development of an embedded real-time fruit detection system for future automatic fruit harvesting. The proposed embedded system is based on an ARM Cortex-M4 (STM32F407VGT6) processor and an Omnivision OV7670 color camera. The future goal of this embedded vision system will be to control a robotized arm to automatically select and pick some fruit directly from the tree. The complete embedded system has been designed to be placed directly in the gripper tool of the future...

  7. Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

    International Nuclear Information System (INIS)

    Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells. Basal and interferon-alpha (IFN-α) or interferon-gamma (IFN-γ)-induced expression of SOCS1 and SOCS3 proteins was evaluated by immunoblot analysis in a panel of n = 10 metastatic human melanoma cell lines, in human embryonic melanocytes (HEM), and radial or vertical growth phase melanoma cells. Over-expression of SOCS1 and SOCS3 proteins in melanoma cells was achieved using the PINCO retroviral vector, while siRNA were used to inhibit SOCS1 and SOCS3 expression. Tyr701-phosphorylated STAT1 (P-STAT1) was measured by intracellular flow cytometry and IFN-stimulated gene expression was measured by Real Time PCR. SOCS1 and SOCS3 proteins were expressed at basal levels in melanocytes and in all melanoma cell lines examined. Expression of the SOCS1 and SOCS3 proteins was also enhanced following stimulation of a subset of cell lines with IFN-α or IFN-γ. Over-expression of SOCS proteins in melanoma cell lines led to significant inhibition of Tyr701-phosphorylated STAT1 (P-STAT1) and gene expression following stimulation with IFN-α (IFIT2, OAS-1, ISG-15) or IFN-γ (IRF1). Conversely, siRNA inhibition of SOCS1 and SOCS3 expression in melanoma cells enhanced their responsiveness to interferon stimulation. These data demonstrate that SOCS proteins are expressed in human melanoma cell lines and their modulation can influence the responsiveness of melanoma cells to IFN-α and IFN-γ

  8. Real-time Face Detection and Tracking Using Haar Classifier on SoC

    OpenAIRE

    Rajashree Tripathy; R N Daschoudhury

    2014-01-01

    In this paper we intend to Implement a real time Face detection and tracking the head poses position from high definition video using Haar Classifier through Raspberry Pi BCM2835 CPU processor which is a combination of SoC with GPU based Architecture. OV5647 CMOS Image sensor with 5-megapixel used for obtaining high definition video H.264 video data via GPU’s hardware video decoder to improve the playback of H.264 Video data supporting from 1080p at 30fps with complete user control over fo...

  9. Image Processing Based on ARM Embedded Operating System%基于 ARM 嵌入式操作系统的图像处理*

    Institute of Scientific and Technical Information of China (English)

    左春雪; 吉喆明; 黄小红

    2015-01-01

    无人清扫机器人是通过感知外界环境信息,传输到主控制器,实现自我决策并进行自主导航和壁障的。针对这个情况,论文通过A RM嵌入式操作系统和视觉检测系统对所拍摄图像进行边缘检测。以微控制器S3C2440为核心通过可输出标准的数字图像信号OV7670图像传感器对图像进行采集、通过邻域平均法对图像进行预处理和通过Sobel算子对图像边缘进行检测,为了进一步提高视觉检测系统的实时性和可靠性,在ARM上移植了嵌入式Red Hat 9.0 Linux操作系统,并通过U‐boot对bootloade进行移植,作为嵌入式操作系统中一段启动代码,起到引导加载启动程序的任务。在嵌入式Linux操作系统中,完成了视觉系统中邻域平均法图像预处理和Sobel边缘检测算子的软件设计。最后通过系统的软硬件调试,实时的显示出所拍摄图像的边缘,为无人清扫机器人提供了视觉信息。%Unmanned cleaning robots through the perception of external environment information ,transfer to the main controller ,and realize self decision ,autonomous navigation and walls .Aiming at this situation ,the paper demonstrates a fact the detecting photograph image edge through the ARM embedded operating system and visual inspection system . S3C2440 is considered as the core controller ,through an OV7670 image sensor that can produce digital image signal acquiring the image ,through the neighborhood averaging method preprocessing the image and through Sobel operator detecting the im‐age edge .In order to further improve the real‐time performance and reliability of the visual inspection system ,we transplant the embedded Red Hat Linux 9 .0 operating system on the ARM ,completing the neighborhood averaging method in visual system image preprocessing and Sobel edge detection operator in the software design .Finally ,by system software and hard‐ware debugging ,we can acquire real

  10. 基于 ARM 嵌入式操作系统的图像处理*%Image Processing Based on ARM Embedded Operating System

    Institute of Scientific and Technical Information of China (English)

    左春雪; 吉喆明; 黄小红

    2015-01-01

    无人清扫机器人是通过感知外界环境信息,传输到主控制器,实现自我决策并进行自主导航和壁障的。针对这个情况,论文通过A RM嵌入式操作系统和视觉检测系统对所拍摄图像进行边缘检测。以微控制器S3C2440为核心通过可输出标准的数字图像信号OV7670图像传感器对图像进行采集、通过邻域平均法对图像进行预处理和通过Sobel算子对图像边缘进行检测,为了进一步提高视觉检测系统的实时性和可靠性,在ARM上移植了嵌入式Red Hat 9.0 Linux操作系统,并通过U‐boot对bootloade进行移植,作为嵌入式操作系统中一段启动代码,起到引导加载启动程序的任务。在嵌入式Linux操作系统中,完成了视觉系统中邻域平均法图像预处理和Sobel边缘检测算子的软件设计。最后通过系统的软硬件调试,实时的显示出所拍摄图像的边缘,为无人清扫机器人提供了视觉信息。%Unmanned cleaning robots through the perception of external environment information ,transfer to the main controller ,and realize self decision ,autonomous navigation and walls .Aiming at this situation ,the paper demonstrates a fact the detecting photograph image edge through the ARM embedded operating system and visual inspection system . S3C2440 is considered as the core controller ,through an OV7670 image sensor that can produce digital image signal acquiring the image ,through the neighborhood averaging method preprocessing the image and through Sobel operator detecting the im‐age edge .In order to further improve the real‐time performance and reliability of the visual inspection system ,we transplant the embedded Red Hat Linux 9 .0 operating system on the ARM ,completing the neighborhood averaging method in visual system image preprocessing and Sobel edge detection operator in the software design .Finally ,by system software and hard‐ware debugging ,we can acquire real

  11. Low Noise Readout Circuit for Biosensor SoC

    Institute of Scientific and Technical Information of China (English)

    PAN Yin-song; KONG Mou-fu; LI Xiang-quan; WANG Li

    2008-01-01

    Presented is a low noise interface circuit that is tuned to the needs of self-assembly monolayers biosensor SoC. The correlated double sampling(CDS) unit of the readout circuit can reduce 1/f noise, KTC noise and fixed noise of micro arrays effectively. The circuit is simulated in a 0.6 μm/level 7 standard CMOS process, and the simulated results show the output voltage has a good linearity with the transducing current of the micro arrays. This is a novel circuit including four amplifiers sharing a common half-circuit and the noise reducing CDS unit. It could be widely used for micro array biosensors.

  12. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha

    DEFF Research Database (Denmark)

    Brender, C; Lovato, P; Sommer, V H;

    2005-01-01

    Signal transducer and activator of transcription (Stat)3 is constitutively activated in cutaneous T-cell lymphoma (CTCL), where it protects tumour cells against apoptosis. The constitutive activation of Stat3 leads to a constitutive expression of suppressor of cytokine signalling (SOCS)-3. In...... healthy cells, SOCS-3 is transiently expressed following cytokine stimulation and functions as a negative feedback inhibitor of the Stat3-activating kinases. Here, we attempt to resolve the apparent paradox of a simultaneous SOCS-3 expression and Stat3 activation in the same cells. We show that (i) SOCS-3...... expression in tumour cells is equal to or higher than in cytokine-stimulated nonmalignant T cells, (ii) SOCS-3 is not mutated in CTCL, (iii) overexpression of SOCS-3 blocks IFNalpha-mediated growth inhibition without affecting Stat3 activation, growth, and apoptosis, and (iv) inhibition of SOCS-3 by a...

  13. The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

    DEFF Research Database (Denmark)

    Vesterlund, Mattias; Zadjali, Fahad; Persson, Torbjörn;

    2011-01-01

    to GH is under regulatory control to avoid excessive and off-target effects upon GHR activation. The suppressor of cytokine signalling 2 (SOCS) is a key regulator of GHR sensitivity. This is clearly shown in mice where the SOCS2 gene has been inactivated, which show 30-40% increase in body length, a...... phenotype that is dependent on endogenous GH secretion. SOCS2 is a GH-stimulated, STAT5b-regulated gene that acts in a negative feedback loop to downregulate GHR signalling. Since the biochemical basis for these actions is poorly understood, we studied the molecular function of SOCS2. We demonstrated that...... SOCS2 is part of a multimeric complex with intrinsic ubiquitin ligase activity. Mutational analysis shows that the interaction with Elongin B/C controls SOCS2 protein turnover and affects its molecular activity. Increased GHR levels were observed in livers from SOCS2(-/-) mice and in the absence of...

  14. A control system of mobile navigation robot for precise spraying based ultrasonic detecting and ARM embedded technologies

    Science.gov (United States)

    Tang, Xiuying; Li, Cuiling; Wang, Xiu; Yue, Xinpeng; Peng, Yankun

    2011-06-01

    This paper described a control system of mobile navigation robot for precision spraying in greenhouse environment, which were composed of main control module, motor driving module, ultrasonic detecting module and wirless remote control module. The hard circuits of control system were built. The main control module used ARM7TDMI-S-based LPC2210 micro-processing controller. The motor driving module consisted of voltage amplifier circuit based SN74LS245N and DM74LS244N chips, RC filter circuit, and HM-YZ-30 DC brush motor driver. The ultrasonic detecting module consisted of four standard ultrasonic ranging modules which were arranged on the four sides around the mobile navigation robot, and used GM8125 chip to expand serial communication interfaces. An obstacle-avoiding strategy and its algorithm were proposed and the control programs of mobile navigation robot were programmed. The mobile navigation robot for spraying can realize the actions such as starting and stopping, forward and backward moving, accelerate and decelerate motion, and right and left turn. Finally, the functional experiments of the mobile navigation robot were conducted in the laboratory environment. The results showed that the ultrasonic detecting distance of the robot was 50.5mm-1832.0mm and detecting blind zone was less than 50mm, the ultrasonic detecting angle of individual ultrasonic detecting module of robot was similar to U-shaped and its vaule was about 45.66°, and the moving path of navigation robot was approximately linear.

  15. Comparison of the CALIPSO satellite and ground-based observations of cirrus clouds at the ARM TWP sites

    Energy Technology Data Exchange (ETDEWEB)

    Thorsen, Tyler J.; Fu, Q.; Comstock, Jennifer M.

    2011-11-10

    Statistics of ice cloud macrophysical and optical properties from the Cloud-Aerosol LIdar with Orthogonal Polarization (CALIOP) instrument on board the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) satellite are compared with those from ground-based lidar observations over a 31 month period. Ground-based lidar observations are taken from the micropulse lidars (MPL) at the three Department of Energy Atmospheric Radiation Measurement (ARM) tropical western pacific (TWP) sites: Manus, Nauru and Darwin. CALIPSO observations show a larger cloud fraction at high altitudes while the ground-based MPLs show a larger cloud fraction at low altitudes. The difference in mean ice cloud top and base heights at the Manus and Nauru sites are all within 0.51 km, although differences are statistically significant. Mean ice cloud geometrical thickness agree to within 0.05 km at the Manus and Nauru sites. Larger differences exist at Darwin due to excessive degradation of the MPL output power during our sampling period. Both sets of observations show thicker clouds during the nighttime which may be real but could also be partially an artifact of the decreased signal-to-noise ratio during the daytime. The number of ice cloud layers per profile are also shown to be consistent after accounting for the difference in spatial resolution. For cloud optical depths, four different retrieval methods are compared, two for each set of observations. All products show that the majority of ice cloud optical depths ({approx}60%) fall below an optical depth of 0.2. For most comparisons all four retrievals agree to within the uncertainty intervals. We find that both CALIPSO retrievals agree best to ground-based optical depths when the lidar ratio in the latter is retrieved instead of set to a fixed value. Also thoroughly compared is the cloud properties for the subset of ice clouds which reside in the tropical tropopause layer (TTL).

  16. The Research and Design for the Embedded System Based on ARM9%基于ARM9的嵌入式系统研究及设计

    Institute of Scientific and Technical Information of China (English)

    薛凌燕; 杨吉宏; 李凌云; 郑志新

    2009-01-01

    为适应嵌入式技术在现代工业及电子等更多领域的广泛应用,通过对ARM9嵌入式微处理器芯片S3C2410的研究,设计出基于S3C2410核心板的嵌入式系统开发底板,更多的需求及功能可在其底板上进行扩展与实现.首先对ARM9嵌入式微处理器S3C2410进行介绍,然后给出了基于S3C2410核心板的嵌入式系统开发底板的设计与功能扩展,包括开发板总体设计,电源模块设计,各种通信模块设计如串口、JTAG接口、网络接口、CAN总线通信接口等.该模板的设计实现了嵌入式系统在更多更广泛领域应用的灵活性.%To adapting for the embedded technology's application widely in the modern industry, electron and so on,it is the design for the embedded system exploitation motherboard based on S3C2410 core board through the research on ARM9 embedded microprocessor S3C2410. More demand and function can extend and come true on the motherboard. Firstly, introduce ARM9 embedded microprocessor S3C2410. Then introduce the design for the embedded system exploitation motherboard based on S3C2410 core board and the function extend, including exploitation motherboards' collectivity design, power supply design, all kinds of communication module design, such as serial interface, JTAG interface, network interface, CAN bus communication interface and so on. The motherboard's design has realized the embedded system application's flexibility.

  17. 类风湿性关节炎患者血清及关节积液SOCS-1、SOCS-3蛋白的含量检测及意义%The content and value of SOCS-1 and SOCS-3 proteins in serum and synovial fluid of patients with rheumatoid arthritis

    Institute of Scientific and Technical Information of China (English)

    林栋; 汪铁军; 钱一龙

    2012-01-01

    Objective To investigate the changes of the levels of serum and synovial fluid SOCS-1, SOCS-3 in patients with rheumatoid arthritis( RA ), and to explore the value of SOCS-1 and SOCS-3 in inflammatory reaction of rheumatoid arthritis. Methods 49 patients with rheumatoid arthritis were divided into active RA group( 26 cases ) and non- active RA group( 23 cases jaccording to disease activity index. The levels of serum and synovial fluid SOCS-1, SOCS-3 were detected by ELISA, while the 20 health)' control were compiled into the control group. Results The levels of serum SOCS-1 and SOCS-3 were significantly higher in RA group than those in control group( P < 0. 01 ), which were significantly higher in active RA group than those in non- active RA group( P < 0. 01, P < 0. 05 ). The levels of synovial fluid SOCS-1 and SOCS-3 were significantly higher in active RA group than those in non- active RA group( P <0. 05 ). The levels of serum SOCS-1 and SOCS-3 were positively correlated with the serum ESR,CRP,RF ( P <0. 01 ,P <0. 05 ). Conclusions SOCS-1 and SOCS-3 may play an important role in the pathological process of inflammatory response in rheumatoid arthritis, which ma)' be related to activity of rheumatoid arthritis.%目的 观察类风湿性关节炎(RA)患者血清及关节液SOCS-1、SOCS-3蛋白含量的变化,探讨其在炎症中的意义.方法 49例类风湿性关节炎患者根据疾病活动性分为活动期组(26例)及缓解期组(23例),采用ELISA法检测其血清及关节液SOCS-1、SOCS-3蛋白含量,并与20例健康体检者(对照组)进行比较.结果 与对照组比较,RA患者中活动期组与缓解期组血清SOCS-1、SOCS-3蛋白含量均明显升高(P<0.01),其中活动期组血清SOCS-1、SOCS-3含量表达较缓解组明显升高(P<0.01、P<0.05);活动期组患者关节积液SOCS-1、SOCS-3蛋白表达较缓解期组明显升高(P<0.05);活动期组患者血清SOCS-1、SOCS-3蛋白水平均与血清ESR、CRP、RF呈正相关(P<0.01、P<0

  18. Ternary Tree Asynchronous Interconnect Network for GALS' SOC

    Directory of Open Access Journals (Sweden)

    Vivek E. Khetade

    2013-03-01

    Full Text Available Interconnect fabric requires easy integration of computational block operating with unrelated clocks.Thispaper presents asynchronous interconnect with ternary tree asynchronous network for GloballyAsynchronous Locally Synchronous (GALS system-on-chip (SOC. Here architecture is proposed forinterconnection with ternary tree asynchronous network where ratio of number NOC design unit andnumber of router is 4:1,6:2, 8:3,10:4 etc .It is scalable for any number of NOC design unit. It offersaneasy integration of different clock domain with lowcommunication overhead .NOC design unit for GALS‘SOC is formulated by wrapping synchronous module with input port along with input port controller,output port along with output port controller and local clock generator. It creates the interface betweensynchronous to asynchronous and asynchronous to synchronous. For this purpose four port asynchronousrouters is designed with routing element and outputarbitration and buffering with micro-pipeline. Thisinterconnect fabric minimizes silicon area, minimize Latency and maximize throughput. Here functionalmodel is made for TTAN and application MPEG4 is mapped on the Network .Desired traffic pattern isgenerated and performance of the network is evaluated. Significant improvement in the networkperformance parameter has been observed.

  19. The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in polio survivors: protocol for a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Murray Deirdre

    2012-12-01

    Full Text Available Abstract Background Many Polio survivors have reduced mobility, pain and fatigue, which make access to conventional forms of aerobic exercise difficult. Inactivity leads to increased risk of health problems, many of which are prevalent among Polio survivors. Aerobic exercise programmes in Polio survivors should utilise stable muscle groups and should be designed to minimise exacerbation of pain and fatigue. A home-based arm ergometry aerobic exercise programme may represent an affordable and accessible exercise modality, incorporating exercise prescription principles in this group. Methods/design This is a prospective, single blinded, randomised controlled trial. There are two arms; exercise intervention using arm ergometers and control. Polio survivors meeting eligibility criteria will be recruited and randomly allocated to intervention or control groups. Participants allocated to the intervention group will receive a small arm ergometer and a polar heart rate monitor. They will carry out a home-based moderate intensity (50-70% HRMax aerobic exercise programme for eight weeks, following instruction by the treating physiotherapist. Assessments will occur at baseline and after eight weeks and will include tests of physical fitness, activity, energy cost of walking, fatigue and quality of life. Clinically feasible assessment tools including the Six Minute Arm Test, the Physical Activity Scale for People with Physical Disabilities questionnaire, the Physiological Cost Index, Fatigue Severity Scale and the SF-36v2 will be utilised. Discussion The efficacy of a home-based arm ergometry programme in Polio survivors will be examined. No previous trial has examined such a programme using a wide range of outcome measures pertinent to Polio survivors. This study will provide new information on the impact of arm ergometry on physical fitness, activity, body composition, fatigue, pain, muscle strength, and health related quality of life. Also, the study

  20. Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression.

    Science.gov (United States)

    Zhang, Xin; Liu, Junling; Zang, Dan; Wu, Shu; Liu, Aibin; Zhu, Jinrong; Wu, Geyan; Li, Jun; Jiang, Lili

    2015-06-20

    Ovarian cancer is a gynecological malignancy with high mortality rates worldwide and novel diagnostic and prognostic markers and therapeutic targets are urgently required. The suppressor of cytokine signaling 1 (SOCS1) and cyclin-dependent kinase inhibitor 1A (p21(KIP)) are known to regulate tumor cell proliferation. However, the mechanisms that regulate these genes have not yet been completely elucidated. In the present study, analysis of a published microarray-based high-throughput assessment (NCBI/E-MTAB-1067) and real-time PCR demonstrated that miR-572 was upregulated in human ovarian cancer tissues and cell lines. Kaplan-Meir analysis indicated that high level expression of miR-572 was associated with poorer overall survival. Ectopic miR-572 promoted ovarian cancer cell proliferation and cell cycle progression in vitro and tumorigenicity in vivo. SOCS1 and p21 were identified as direct targets of miR-572 and suppression of SOCS1 or p21 reversed the inhibiting-function of miR-572-silenced cell on proliferation and tumorigenicity in ovarian cancer cells. Additionally, the expression of miR-572 correlated inversely with the protein expression levels of SOCS1, p21 and positively with Cyclin D1 in ovarian carcinoma specimens. This study demonstrates that miR-572 post-transcriptionally regulates SOCS1 and p21 and may play an important role in ovarian cancer progression; miR-572 may represent a potential therapeutic target for ovarian cancer therapy. PMID:25893382

  1. Immobilization of pectinase on silica-based supports: Impacts of particle size and spacer arm on the activity.

    Science.gov (United States)

    Alagöz, Dilek; Tükel, S Seyhan; Yildirim, Deniz

    2016-06-01

    The pectinase was separately immobilized onto Florisil and nano silica supports through both glutaraldehyde and 3-glyoxypropyltrietoxysilane spacer arms. The effects of spacer arm, particle size of support and ionic liquids on the activities of pectinase preparations were investigated. The immobilization of pectinase onto Florisil and nano silica through 3-glyoxypropyltrietoxysilane spacer arm completely led to inactivation of enzyme; however, 10 and 75% pectinase activity were retained when it was immobilized through glutaraldehyde spacer arm onto Florisil and nano silica, respectively. The pectinase immobilized onto nano silica through glutaraldehyde spacer arm showed 6.3-fold higher catalytic efficiency than that of the pectinase immobilized onto Florisil through same spacer arm. A 2.3-fold increase in thermal stability of pectinase was provided upon immobilization onto nano silica at 35°C. The effects of IL/buffer mixture and volume ratio of IL/buffer mixture on the catalytic activities of free and immobilized pectinase preparations were also tested. All the pectinase preparations showed highest activity in 10% (v/v) 1-butyl-3-methylimidazolium hexafluorophosphate containing medium and their activities significantly affected from the concentration of 1-butyl-3-methylimidazolium hexafluorophosphate. PMID:26964525

  2. Evaluation of Arm Processor-based Bionic Intelligent Controller for a Buck-boost Converte

    Directory of Open Access Journals (Sweden)

    M.V. Mini

    2015-07-01

    Full Text Available This study focuses on performance-comparison of different tuning methods for a PI controller applied to a buck-boost converter. Comparison between the controllers is made by analysis of design methodology implementation issues and empirically measured performance. Design of PI controller is based on frequency response of the converter. The optimization of PI controller is based on ant colony algorithm. Experimental results show that, tuning the PI controller using ACO algorithm gave better performance than the conventional algorithm. This is mainly due to the fact ACO is capable of reducing the overshoot without oscillation.

  3. Expression of SOCS1 and SOCS3 genes in human graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

    Science.gov (United States)

    Lee, Tae Hyang; Lee, Ji Yoon; Park, Sohye; Shin, Seung Hwan; Yahng, Seung-Ah; Yoon, Jae-Ho; Lee, Sung-Eun; Cho, Byung-Sik; Kim, Yoo-Jin; Lee, Seok; Min, Chang-Ki; Kim, Dong-Wook; Lee, Jong-Wook; Min, Woo-Sung; Park, Chong-Won

    2013-01-01

    Background Suppressor of cytokine signaling genes (SOCS) are regarded as pivotal negative feedback regulators of cytokine signals, including the interferon-gamma (IFN-γ), granulocyte-colony stimulating factor, and interleukin families, released by T cells. A detailed understanding of the involvement of SOCS genes in graft-versus-host disease (GVHD) is critical to effectively manage GVHD, yet their expression patterns among recipients remain largely unexplored. Methods Expression levels of SOCS1 and SOCS3 were determined by real-time quantitative reverse transcription PCR (qRT-PCR) in patients with acute GVHD (aGVHD) and chronic GVHD (cGVHD), in a severity-dependent manner, after allogeneic hematopoietic stem cell transplantation (HSCT). A total of 71 recipients with AML (N=40), ALL (N=12), myelodysplastic syndromes (MDS; N=10), chronic myelogenous leukemia (CML; N=2), severe aplastic anemia (SAA; N=5), or others (N=2), who received allogeneic HSCT from human leukocyte antigen-identical siblings or unrelated donors between 2009 and 2011, were included in the present study. Results Overall, the expression levels of SOCS1 decreased in recipients with grade II to IV aGVHD and cGVHD when compared to normal donors and non-GVHD recipients. Interestingly, the expressions of SOCS1 decreased significantly more in cGVHD than in aGVHD recipients (P=0.0091). In contrast, SOCS3 expressions were similarly reduced in all the recipients. Conclusion This is the first study to show that SOCS1 and SOCS3 are differentially expressed in recipients following allogeneic HSCT, suggesting a prognostic correlation between SOCS genes and the development of GVHD. This result provides a new platform to study GVHD immunobiology and potential diagnostic and therapeutic targets for GVHD. PMID:23589790

  4. Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

    Science.gov (United States)

    Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

    2012-12-01

    under grassland, with a root mean square error (RMSE) of 3.6 and 7.2 g C kg-1 respectively, while mineral soils under woodland and organic soils predictions were less accurate (RMSE of 11.9 and 51.1 g C kg-1). The RMSE was lower (except for organic soils) when sand content was used as covariate in the selection of the l-PLS predicting neighbours. The obtained results proved that: (i) Although the enormous spatial variability of European soils, the developed modified l-PLS algorithm was able to produce stable calibrations and accurate predictions. (ii) It is essential to invest in spectral libraries built according to sampling strategies, based on soil types, and a standardized laboratory protocol. (iii) Vis-NIR DRS spectroscopy is a powerful and cost effective tool to predict SOC content at regional/continental scales, and should be converted from a pure research discipline into a reference operational method decreasing the uncertainties of SOC monitoring and terrestrial ecosystems carbon fluxes at all scales.

  5. Variance-based iterative image reconstruction from few views in limited-angle C-arm computed tomography

    Science.gov (United States)

    El Hakimi, Wissam; Sakas, Georgios

    2014-03-01

    C-arm cone-beam computed tomography offers CT-like 3D imaging capabilities, but with the additional advantage of being appropriate for interventional suites. Due to the limitations of the data acquisition system, projections are oft acquired in a short scan angular range, resulting in significant artifacts, if conventional analytic formulas are applied. Furthermore, the presence of high-density objects, like metal parts, induces streak-like artifacts, which can obscure relevant anatomy. We present a new algorithm to reduce such artifacts and enhance the quality of reconstructed 3D volume. We make use of the variance of estimated voxel values over all projections to decrease the ground artifact level. The proposed algorithm is less sensitive to data truncation, and does not require explicit estimation of missing data. The number of required images is very low (up to 56 projections), which have several benefits, like significant reduction of patient dose and shortening of the acquisition time. The performance of the proposed method is demonstrated based on simulations and phantom data.

  6. Authentication System for Smart Homes Based on ARM7TDMI-S and IRIS-Fingerprint Recognition Technologies

    Directory of Open Access Journals (Sweden)

    Fredrick R. Ishengoma

    2014-12-01

    Full Text Available With the rapid advancement in technology, smart homes have become applicable and so the need arise to solve the security challenges that are accompanied with its operation. Passwords and identity cards have been used as traditional authentication mechanisms in home environments, however, the rise of misuse of these mechanisms are proving them to be less reliable. For instance, ID cards can be misplaced, copied or counterfeited and being misused. Conversely, studies have shown that biometrics authentication systems particularly Iris Recognition Technology (IRT and Fingerprint Recognition Technology (FRT have the most reliable mechanisms to date providing tremendous accuracy and speed. As the technology becomes less expensive, application of IRT& FRT in smart-homes becomes more reliable and appropriate solution for security challenges. In this paper, we present our approach to design an authentication system for smart homes based on IRT, FRT and ARM7TDMI-S.The system employs two biometrics mechanisms for high reliability whereby initially, system users must enroll their fingerprints and eyes into the camera. Iris and fingerprint biometrics are scanned and the images are stored in the database. In the stage of authentication, FRT and IRT fingerprint scan and analyze points of the user's current input iris and fingerprint and match with the database contents. If one or more captured images do not match with the one in the database, then the system will not give authorization.

  7. Dynamics Modeling and Robust Trajectory Tracking Control for a Class of Hybrid Humanoid Arm Based on Neural Network

    Institute of Scientific and Technical Information of China (English)

    WANG Yueling; JIN Zhenlin

    2009-01-01

    In order to solve the problem of trajectory tracking for a class of novel serial-parallel hybrid humanoid arm(HHA), which has parameters uncertainty, frictions, disturbance, abrasion and pulse forces derived from motors, a multistep dynamics modeling strategy is proposed and a robust controller based on neural network(NN)-adaptive algorithm is designed. At the first step of dynamics modeling, the dynamics model of the reduced HHA is established by Lagrange method. At the second step of dynamics modeling, the parameter uncertain part resulting mainly from the idealization of the HHA is learned by adaptive algorithm. In the trajectory tracking controller, the radial basis function(RBF) NN, whose optimal weights are learned online by adaptive algorithm, is used to learn the upper limit function of the total uncertainties including frictions, disturbances, abrasion and pulse forces. To a great extent, the conservatism of this robust trajectory tracking controller is reduced, and by this controller the HHA can impersonate mostly human actions. The proof and simulation results testify the validity of the adaptive strategy for parameter learning and the neural network-adaptive strategy for the trajectory tracking control.

  8. Balance maintenance in high-speed motion of humanoid robot arm-based on the 6D constraints of momentum change rate.

    Science.gov (United States)

    Zhang, Da-song; Xiong, Rong; Wu, Jun; Chu, Jian

    2014-01-01

    Based on the 6D constraints of momentum change rate (CMCR), this paper puts forward a real-time and full balance maintenance method for the humanoid robot during high-speed movement of its 7-DOF arm. First, the total momentum formula for the robot's two arms is given and the momentum change rate is defined by the time derivative of the total momentum. The author also illustrates the idea of full balance maintenance and analyzes the physical meaning of 6D CMCR and its fundamental relation to full balance maintenance. Moreover, discretization and optimization solution of CMCR has been provided with the motion constraint of the auxiliary arm's joint, and the solving algorithm is optimized. The simulation results have shown the validity and generality of the proposed method on the full balance maintenance in the 6 DOFs of the robot body under 6D CMCR. This method ensures 6D dynamics balance performance and increases abundant ZMP stability margin. The resulting motion of the auxiliary arm has large abundance in joint space, and the angular velocity and the angular acceleration of these joints lie within the predefined limits. The proposed algorithm also has good real-time performance. PMID:24883404

  9. Accuracy of x-ray image-based 3D localization from two C-arm views: a comparison between an ideal system and a real device

    Science.gov (United States)

    Brost, Alexander; Strobel, Norbert; Yatziv, Liron; Gilson, Wesley; Meyer, Bernhard; Hornegger, Joachim; Lewin, Jonathan; Wacker, Frank

    2009-02-01

    arm X-ray imaging devices are commonly used for minimally invasive cardiovascular or other interventional procedures. Calibrated state-of-the-art systems can, however, not only be used for 2D imaging but also for three-dimensional reconstruction either using tomographic techniques or even stereotactic approaches. To evaluate the accuracy of X-ray object localization from two views, a simulation study assuming an ideal imaging geometry was carried out first. This was backed up with a phantom experiment involving a real C-arm angiography system. Both studies were based on a phantom comprising five point objects. These point objects were projected onto a flat-panel detector under different C-arm view positions. The resulting 2D positions were perturbed by adding Gaussian noise to simulate 2D point localization errors. In the next step, 3D point positions were triangulated from two views. A 3D error was computed by taking differences between the reconstructed 3D positions using the perturbed 2D positions and the initial 3D positions of the five points. This experiment was repeated for various C-arm angulations involving angular differences ranging from 15° to 165°. The smallest 3D reconstruction error was achieved, as expected, by views that were 90° degrees apart. In this case, the simulation study yielded a 3D error of 0.82 mm +/- 0.24 mm (mean +/- standard deviation) for 2D noise with a standard deviation of 1.232 mm (4 detector pixels). The experimental result for this view configuration obtained on an AXIOM Artis C-arm (Siemens AG, Healthcare Sector, Forchheim, Germany) system was 0.98 mm +/- 0.29 mm, respectively. These results show that state-of-the-art C-arm systems can localize instruments with millimeter accuracy, and that they can accomplish this almost as well as an idealized theoretical counterpart. High stereotactic localization accuracy, good patient access, and CT-like 3D imaging capabilities render state-of-the-art C-arm systems ideal devices for X

  10. Oilwell Monitoring and Control based on Wireless Sensor Networks using ARM

    OpenAIRE

    V. Viknesh Velavan; R.Chandralekha

    2012-01-01

    The existing oil-pumping unit (OPU) system has a high power consuming process. It has the incapability of OPU’s structural health monitoring. A sensor network based intelligent control is proposed for power economy and efficient oilwell health monitoring using wireless sensor network. The proposed system consists of three-level sensors: First level sensors (FLS) – designed with a temperature sensor, a voltage sensor, a current sensor, level sensor, gas sensor and a pressure sensor used for o...

  11. Impact of STAT/SOCS mRNA Expression Levels after Major Injury

    Directory of Open Access Journals (Sweden)

    M. Brumann

    2014-01-01

    Full Text Available Background. Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family. Methods. 20 polytraumatized patients were included. Blood samples were drawn 0 h–72 h after trauma; mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3 were quantified by qPCR. Results. IL-10 mRNA expression increased significantly in the early posttraumatic period. STAT 3 mRNA expressions showed a significant maximum at 6 h after trauma. SOCS 1 levels significantly decreased 6 h–72 h after trauma. SOCS 3 levels were significantly higher in nonsurvivors 6 h after trauma. Conclusion. We present a serial, sequential investigation in human neutrophil granulocytes of major trauma patients evaluating mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3. Posttraumatically, immune disorder was accompanied by a significant increase of IL-10 and STAT 3 mRNA expression, whereas SOCS 1 mRNA levels decreased after injury. We could demonstrate that death after trauma was associated with higher SOCS 3 mRNA levels already at 6 h after trauma. To support our results, further investigations have to evaluate protein levels of STAT/SOCS family in terms of posttraumatic immune imbalance.

  12. 寻常型银屑病患者外周血单个核细胞SOCS-1、SOCS-3 mRNA的表达%The expression of SOCS-1 and SOCS-3 mRNA in patients with psoriasis vulgaris

    Institute of Scientific and Technical Information of China (English)

    郭红卫; 王京滨; 李国明; 李顺凡; 吴志华

    2007-01-01

    目的: 检测细胞因子信号抑制因子SOCS-1、SOCS-3 mRNA在寻常型银屑病患者外周血单个核细胞(PBMC)中的表达.方法: 从20例银屑病患者及20例健康志愿者外周血中分离PBMC,提取RNA,应用逆转录-聚合酶链反应(RT-PCR)方法检测SOCS-1、SOCS-3 mRNA的表达.结果: SOCS-1、SOCS-3 mRNA在银屑病患者中表达,在正常人中无表达,活动期银屑病患者较静止期患者SOCS-1、SOCS-3 mRNA表达增高.结论: SOCS-1、SOCS-3可能在银屑病的Th1免疫反应中发挥作用.

  13. Electromagnetic field-based navigation for percutaneous punctures on C-arm CT: experimental evaluation and clinical application

    International Nuclear Information System (INIS)

    The aim of this study was to prospectively evaluate the needle visualization and placement error and use of an electromagnetic field-based tracking navigation device for puncture procedures based on C-arm CT (CACT) images. A commercially available navigation device was mounted on an angiographic X-ray system setup for CACT. After the target was defined, needle placement was performed under real-time visualization of the virtual needle in CACT images. The final, real needle position was assessed by CACT. Punctures were performed in phantoms (n = 76) and in twelve patients (eight biopsies, three drainages, one injection). Procedure times, system error, user error and total error were assessed. In phantoms, mean total error was 2.3 ± 0.9 mm, user error was 1.4 ± 0.8 mm and system error was 1.7 ± 0.8 mm. In the patient study, the targeted puncture was successful in all twelve cases. The mean total error was 5.4 mm ± 1.9 mm (maximum 8.1 mm), user error was 3.7 ± 1.7 mm, system error was 3.2 ± 1.4 mm and mean skin-to-target time was less than 1 min. The navigation device relying on CACT was accurate in terms of needle visualization and useful for needle placement under both experimental and clinical conditions. For more complex procedures, electromagnetic field-based tracking guidance might be of help in facilitating the puncture and reducing both the puncture risk and procedure time. (orig.)

  14. Automatic Control System for Refining Sugarcane Based on Embedded ARM-Linux and ZigBee%基于ARM-Linux和ZigBee的自动煮糖数据采集系统

    Institute of Scientific and Technical Information of China (English)

    王敦锋; 朱名日; 庾志衡; 周信东

    2011-01-01

    According to the special environment of refining; sugarcane production line,a RT data sugar-refine control platform of wireless sensor network based on Zigbee and arm-linux technology was built. The problems of traditional cable data acquisition system such as high cost.poor scalabiliiy of monitoring node,bad mobility were solved. A new way was achieved for the process automation of refinining sugar. The test result shows that the system runs well, and completely meets the requirements of produccion process.%针对糖厂煮糖制炼生产线的特殊环境,利用ZigBee和嵌入式ARM-Linux技术,构建了1个实时的蔗糖制炼无线传感器网络控制平台,有效解决传统的有线数据采集系统存在的成本较高、监控点扩充性差、移动性较差等问题,为实现煮糖过程的自动化提供了手段.测试表明,系统运行良好,能够满足工艺的要求.

  15. ARM-LINUX BASED GUI SYSTEM ARCHITECTURE ANALYSIS AND ITS APPLICATION DESIGN%基于ARM-Linux的GUI系统体系分析及其应用设计

    Institute of Scientific and Technical Information of China (English)

    杜智敏; 谢维波; 谢毅勇

    2011-01-01

    To realize a well performing embedded GUI system, it is required that the developers clearly understand not only the operation system with all its low level hardware components, but also their interactions. The thesis illustrates GUI' s core design concept, additionally carries out exhaustive analysis and discussion upon ARM-Linux based GUI implementation and architecture, then finally proposes MiniGUI-baaed concrete application design, which bears instructive meanings for researchers to develop the embedded GUI system.%实现一个表现良好的嵌入式GUI系统要求开发者对操作系统及底层硬件的各个组件及其之间的交互都十分清楚.阐述GUI的核心设计理念,并对基于ARM-Linux的GUI的实现原理和体系结构进行了详尽的分析探讨,最后给出基于MiniGUI的具体应用设计,对研究人员开发嵌入式GUI系统具有指导意义.

  16. A Call to Arms: Standards for Agent-Based Modeling and Simulation

    OpenAIRE

    Andrew Collins; Mikel Petty; Daniele Vernon-Bido; Solomon Sherfey

    2015-01-01

    Standards are as old as civilization itself and they are vital to human development. Standards touch almost every part of our lives, from the water we drink to the language used to write this article. A sign of a good standard is one that we do not notice. Good standards exist and so do processes and organizations to create and maintain them. As agent-based modeling and simulation matures as a methodology, a discussion of standards applicable to it becomes increasingly important. Descriptive ...

  17. Parametric motion control of robotic arms: A biologically based approach using neural networks

    Science.gov (United States)

    Bock, O.; D'Eleuterio, G. M. T.; Lipitkas, J.; Grodski, J. J.

    1993-01-01

    A neural network based system is presented which is able to generate point-to-point movements of robotic manipulators. The foundation of this approach is the use of prototypical control torque signals which are defined by a set of parameters. The parameter set is used for scaling and shaping of these prototypical torque signals to effect a desired outcome of the system. This approach is based on neurophysiological findings that the central nervous system stores generalized cognitive representations of movements called synergies, schemas, or motor programs. It has been proposed that these motor programs may be stored as torque-time functions in central pattern generators which can be scaled with appropriate time and magnitude parameters. The central pattern generators use these parameters to generate stereotypical torque-time profiles, which are then sent to the joint actuators. Hence, only a small number of parameters need to be determined for each point-to-point movement instead of the entire torque-time trajectory. This same principle is implemented for controlling the joint torques of robotic manipulators where a neural network is used to identify the relationship between the task requirements and the torque parameters. Movements are specified by the initial robot position in joint coordinates and the desired final end-effector position in Cartesian coordinates. This information is provided to the neural network which calculates six torque parameters for a two-link system. The prototypical torque profiles (one per joint) are then scaled by those parameters. After appropriate training of the network, our parametric control design allowed the reproduction of a trained set of movements with relatively high accuracy, and the production of previously untrained movements with comparable accuracy. We conclude that our approach was successful in discriminating between trained movements and in generalizing to untrained movements.

  18. ARM Lead Mentor Selection Process

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, DL

    2013-03-13

    The ARM Climate Research Facility currently operates more than 300 instrument systems that provide ground-based observations of the atmospheric column. To keep ARM at the forefront of climate observations, the ARM infrastructure depends heavily on instrument scientists and engineers, also known as Instrument Mentors. Instrument Mentors must have an excellent understanding of in situ and remote-sensing instrumentation theory and operation and have comprehensive knowledge of critical scale-dependent atmospheric processes. They also possess the technical and analytical skills to develop new data retrievals that provide innovative approaches for creating research-quality data sets.

  19. Simulation of realistic EarthCARE spaceborne Doppler products from ARM ground-based, SPIDER airborne and CRM data

    Science.gov (United States)

    Sy, O. O.; Tanelli, S.; Takahashi, N.; Ohno, Y.; Horie, H.; Kollias, P.

    2011-12-01

    The Cloud-profiling radar on ESA and JAXA's future EarthCARE mission will be the first spaceborne Doppler radar to ever fly [1]. This W-band CPR, which operates at 94.05 GHz, should provide an unprecedented global coverage of vertical-velocity field distribution of the Earth's atmosphere, and therewith a better characterization of dynamic energy transfers in the atmosphere. Prior to EarthCARE's launch, one needs to simulate the Doppler products to be expected from such a CPR, viz. the radar reflectivity and the mean velocity. Our work addresses this need by using existing ground-based and airborne Doppler measurements to generate realistic EarthCARElike spaceborne data. The input to our algorithm consists of actual atmospheric Doppler measurements obtained either from ground-based ARM [2], or from an airborne platform such as SPIDER [3], the Japanese CPR from the National institute od Information and Communications Technologies (NICT). Several corrections are then applied to account for the spacecraft motion as well as the spaceborneantenna characteristics. The realism of the simulated products is also achieved in terms of spatial and temporal resolution. Further, the effects of random fluctuations, noise and finite temporal sampling are included. In addition to highlighting the peculiarities of the generation of Doppler products according to the source of the original input data, our paper will show the corrections that are applied to recover the mean-Doppler velocity, particularly in the presence of aliasing and non-uniform beam-filling contaminations. Several scenarii will be discussed to explore the added value of EarthCARE data at a finer spatial resolution.

  20. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

    DEFF Research Database (Denmark)

    Brender, Christine; Columbus, Ruth; Metcalf, Donald;

    2004-01-01

    the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears...

  1. The development of a general purpose ARM-based processing unit for the ATLAS TileCal sROD

    International Nuclear Information System (INIS)

    After Phase-II upgrades in 2022, the data output from the LHC ATLAS Tile Calorimeter will increase significantly. ARM processors are common in mobile devices due to their low cost, low energy consumption and high performance. It is proposed that a cost-effective, high data throughput Processing Unit (PU) can be developed by using several consumer ARM processors in a cluster configuration to allow aggregated processing performance and data throughput while maintaining minimal software design difficulty for the end-user. This PU could be used for a variety of high-level functions on the high-throughput raw data such as spectral analysis and histograms to detect possible issues in the detector at a low level. High-throughput I/O interfaces are not typical in consumer ARM System on Chips but high data throughput capabilities are feasible via the novel use of PCI-Express as the I/O interface to the ARM processors. An overview of the PU is given and the results for performance and throughput testing of four different ARM Cortex System on Chips are presented

  2. Multi Resolution AHB Bus Tracer with Real Time Compression for SOC

    Directory of Open Access Journals (Sweden)

    J. Jagadish Reddy

    2013-01-01

    Full Text Available AMBA (Advanced Microcontroller based Bus Architecture consists of AHB, APB, ASB and AXI. In this project we are Tracing AHB (Advanced High performance Bus signals with Real time Compression and Multi-resolution Techniques. A simple transaction on the AHB consists of an address phase and a subsequent data phase. Access to the target device is controlled through a MUX , thereby admitting bus-access to one bus-master at a time. In AHB Tracer we have to Trace Address signals, Data signals and Control signals, we have to compress them depending on AHB protocols. A multi-resolution AHB on-chip bus tracer is named as SYS_HMRBT (AHB Multi-resolution Bus Tracer and is used for monitoring. The goal is to provide better compression quality and multiple resolution traces to meet the complex SoC debugging needs. Compressing all signals at cycle-accurate-level does not always meet the debugging needs. As SOCs become more complex, the transaction level debugging becomes increasingly important, since it helps designers focus on the functional behaviors, instead of interpreting complex signals. By using this SYS_HMRBT, we can achieve 79%-96% of compression depending on selected resolution mode. Tools Used for this Project are Modelsim for Simulation, and Xilinx ISE II for Synthesis

  3. EtherBone - A Network Layer for the Wishbone SoC Bus

    CERN Document Server

    Kreider, M; Lewis, J; Włostowski, T; Serrano, J

    2011-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was de...

  4. A new circuit for at-speed scan SoC testing

    International Nuclear Information System (INIS)

    It is very important to detect transition-delay faults and stuck-at faults in system on chip (SoC) under 90 nm processing technology, and the transition-delay faults can only be detected by using an at-speed testing method. In this paper, an on-chip clock (OCC) controller with a bypass function based on an internal phase-locked loop is designed to test faults in SoC. Furthermore, a clock chain logic which can eliminate the metastable state is realized to generate an enable signal for the OCC controller, and then, the test pattern is generated by automatic test pattern generation (ATPG) tools. Next, the scan test pattern is simulated by using the Synopsys tool and the correctness of the design is verified. The result shows that the design of an at-speed scan test in this paper is highly efficient for detecting timing-related defects. Finally, the 89.29% transition-delay fault coverage and the 94.50% stuck-at fault coverage are achieved, and it is successfully applied to an integrated circuit design. (semiconductor integrated circuits)

  5. ETHERBONE - a network layer for the wishbone SoC bus

    International Nuclear Information System (INIS)

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was developed in the scope of the White-Rabbit Timing Project (WR) at CERN and GSI/FAIR, which employs GigaBit Ethernet technology to communicate with memory mapped slave devices. WR will make use of EB as means to issue commands to its timing nodes and control connected accelerator hardware. (authors)

  6. ARM Based Automatic Control System of Nano Positioning Stage for Micromanufacturing

    Directory of Open Access Journals (Sweden)

    Gaurav Singh Naruka

    2013-05-01

    Full Text Available A microcontroller based control system to drive the Physik Instrumente (PI piezoelectric ultrasonic nano-positioning (PUN sta ge for a micro-factory has been proposed by the author. The tuning parameters of th e PI Line Controller are chosen such that the PUN stage shows optimum step response . The microcontroller i.e. LPC2478R provides the user with the choices of oper ations on the 3.2” QVGA LCD screen and the choice can be made by a 5-key joysti ck. The PUN stage moves in different geometrical patterns as chosen by the use r. The stage is placed in the workspace of the Clark-MXRR,Inc. CPA-2101 femto-sec ond laser. Different patterns are made on the material in question. As compared t o the previous works in this area, the user is given the power for position control, r eal time tracking, and trajectory planning of the actuator. The user interface has be en made very easy to comprehend. The repeatability of tasks, portability of the as- sembly, the reduction in the size of the system , power consumption and the human involvemen t are the major achievements after the inclusion of a microcontroller

  7. Oilwell Monitoring and Control based on Wireless Sensor Networks using ARM

    Directory of Open Access Journals (Sweden)

    V. Viknesh Velavan

    2012-09-01

    Full Text Available The existing oil-pumping unit (OPU system has a high power consuming process. It has the incapability of OPU’s structural health monitoring. A sensor network based intelligent control is proposed for power economy and efficient oilwell health monitoring using wireless sensor network. The proposed system consists of three-level sensors: First level sensors (FLS – designed with a temperature sensor, a voltage sensor, a current sensor, level sensor, gas sensor and a pressure sensor used for oilwell data sensing. Intelligent sensors (IS - designed mainly for an oilwell’s data elementary processing, main fault alarm indication, typical storage/indication, data/status transmission up to the third level sensor (TLS, data/status transmission between IS, and command transmission down to the OPU motor. Third level sensors (TLS - Software-defined (SD control centres with an embedded database. The TLS are designed for hundreds of oilwell’s data storage/management, data processing malfunction detection, malfunction alarm/indication; stroke-adjustment command transmission down to a specific IS for power economy and the malfunction report to the maintenance staff. Timer, Keyboard, A/D, communicationinterruptions are controlled by intelligent sensor. Delay aware data collection network structure is used for power economy and to reduce time delay in wireless sensor networks.

  8. Impacts of SOC on car-following behavior and travel time in the heterogeneous traffic system

    Science.gov (United States)

    Tang, Tie-Qiao; Xu, Ke-Wei; Yang, Shi-Chun; Ding, Chuan

    2016-01-01

    Since the SOC (state of charge) of the battery of each electric vehicle directly determines whether the battery should be charged/swapped, the SOC may affect the electric vehicle's driving behavior. In this paper, we introduce the SOC of battery into the electric vehicle's driving behavior model and propose a car-following model for electric vehicles, and then use the proposed model to study the effects of the SOC of battery and battery swap on each vehicle's driving behavior in the heterogeneous traffic system consisting of traditional vehicles and electric vehicles. The numerical results show that the proposed model can reproduce some complex traffic phenomena resulted by the SOC of battery and battery swap and that the influences on each vehicle's driving behavior are directly related to the initial traffic state, the electric vehicle's proportion, and the SOC of battery.

  9. Effects of Action Observational Training Plus Brain-Computer Interface-Based Functional Electrical Stimulation on Paretic Arm Motor Recovery in Patient with Stroke: A Randomized Controlled Trial.

    Science.gov (United States)

    Kim, TaeHoon; Kim, SeongSik; Lee, ByoungHee

    2016-03-01

    The purpose of this study was to investigate whether action observational training (AOT) plus brain-computer interface-based functional electrical stimulation (BCI-FES) has a positive influence on motor recovery of paretic upper extremity in patients with stroke. This was a hospital-based, randomized controlled trial with a blinded assessor. Thirty patients with a first-time stroke were randomly allocated to one of two groups: the BCI-FES group (n = 15) and the control group (n = 15). The BCI-FES group administered to AOT plus BCI-FES on the paretic upper extremity five times per week during 4 weeks while both groups received conventional therapy. The primary outcomes were the Fugl-Meyer Assessment of the Upper Extremity, Motor Activity Log (MAL), Modified Barthel Index and range of motion of paretic arm. A blinded assessor evaluated the outcomes at baseline and 4 weeks. All baseline outcomes did not differ significantly between the two groups. After 4 weeks, the Fugl-Meyer Assessment of the Upper Extremity sub-items (total, shoulder and wrist), MAL (MAL-Activity of Use and Quality of Movement), Modified Barthel Index and wrist flexion range of motion were significantly higher in the BCI-FES group (p BCI-based FES is effective in paretic arm rehabilitation by improving the upper extremity performance. The motor improvements suggest that AOT plus BCI-based FES can be used as a therapeutic tool for stroke rehabilitation. The limitations of the study are that subjects had a certain limited level of upper arm function, and the sample size was comparatively small; hence, it is recommended that future large-scale trials should consider stratified and lager populations according to upper arm function. PMID:26301519

  10. Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression

    OpenAIRE

    Zhang, Xin; Liu, Junling; Zang, Dan; Wu, Shu; Liu, Aibin; Zhu, Jinrong; Wu, Geyan; Li, Jun; Jiang, Lili

    2015-01-01

    Ovarian cancer is a gynecological malignancy with high mortality rates worldwide and novel diagnostic and prognostic markers and therapeutic targets are urgently required. The suppressor of cytokine signaling 1 (SOCS1) and cyclin-dependent kinase inhibitor 1A (p21KIP) are known to regulate tumor cell proliferation. However, the mechanisms that regulate these genes have not yet been completely elucidated. In the present study, analysis of a published microarray-based high-throughput assessment...

  11. Sense of Coherence and Physical Health. A “Copenhagen Interpretation” of Antonovsky's SOC Concept

    OpenAIRE

    P. Christian Endler; Haug, Thomas M.; Heinz Spranger

    2008-01-01

    According to Antonovsky's (Aaron Antonovsky, 1923–1994) sense of coherence (SOC) model, persons with a high SOC have the ability to benefit from their general defense mechanisms in order to overcome stressful situations. In a health-disease continuum, this leads to the development towards health. However, Antonovsky's global hypothesis that the strength of the SOC may influence the physical health status of a person could not be proven.Flensborg-Madsen et al. from Copenhagen were able to prov...

  12. Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction1

    OpenAIRE

    Losman, J. A.; Chen, X.P.; Hilton, D.; Rothman, P.

    1999-01-01

    IL-4 is an important regulator of the activation, proliferation, and differentiation of many hematopoetic cells. Many of these biological effects result from the activation of Janus kinases (JAK)1 and JAK3 and the transcription factor Stat6. Recent data suggest that members of the SOCS (suppressor of cytokine signaling) family of proteins can inhibit JAK-STAT signaling. We have examined the ability of SOCS family members to suppress IL-4 signaling, and we have found that SOCS-1 potently inhib...

  13. Sense of Coherence and Physical Health. A “Copenhagen Interpretation” of Antonovsky's SOC Concept

    Directory of Open Access Journals (Sweden)

    P. Christian Endler

    2008-01-01

    Full Text Available According to Antonovsky's (Aaron Antonovsky, 1923–1994 sense of coherence (SOC model, persons with a high SOC have the ability to benefit from their general defense mechanisms in order to overcome stressful situations. In a health-disease continuum, this leads to the development towards health. However, Antonovsky's global hypothesis that the strength of the SOC may influence the physical health status of a person could not be proven.

  14. 基于 ARM9和 CC2530的远程无线抄表系统设计%The design of remote wireless meter reading system based on ARM 9 and CC2530

    Institute of Scientific and Technical Information of China (English)

    黄璟

    2014-01-01

    针对有线抄表方式空间局限性大、抗干扰能力差等问题,提出了一种基于ARM和ZigBee协议的远程无线抄表系统。该系统由数据采集、数据传输和集抄中心3部分组成。以低功耗片上系统CC2530为核心,采集器配以相应电能计量芯片STPM01进行数据采集,集中器设置了基于μCLinux操作系统的ARM9嵌入式网关,配备打印机接口、触摸屏接口等,用以实现快速现场查询、处理、存储、测试、打印等功能,并为将来复杂无线传感器数据的接入作准备。该无线电能抄表系统具有实用性强、可靠性高、低功耗和可扩展等特点,配置功率放大电路后,有障碍传输距离400 m左右。%For wired meter reading system has space limitations and poor anti-interference ability ,a re-mote meter reading system based on ARM and ZigBee protocol is proposed .This system consists of three parts:data acquisition ,data transmission and control center .Take the low power system-on-chip CC2530 as the core,the design goes together with the corresponding energy metering IC STPM 01 for data collection .Concen-trator is set up the embedded gateway based on ARM 9 and μCLinux operating system .Equipped with printer interface,touch screen interface ,etc.,the system is able to achieve rapid on-site inquiry,process,storage,tes-ting ,printing and other functions ,and make the future preparation of the data access of ubiquitous wireless sen-sor .The wireless meter reading system has strong practicability , high reliability , low power consumption and extensibility etc ,after configuring the power amplification circuit ,the transmission distance of about 400 m.

  15. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    International Nuclear Information System (INIS)

    Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015) and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026). In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002). This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors

  16. Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma.

    Science.gov (United States)

    Iwahori, Kota; Serada, Satoshi; Fujimoto, Minoru; Nomura, Shintaro; Osaki, Tadashi; Lee, Chun Man; Mizuguchi, Hiroyuki; Takahashi, Tsuyoshi; Ripley, Barry; Okumura, Meinoshin; Kawase, Ichiro; Kishimoto, Tadamitsu; Naka, Tetsuji

    2011-08-15

    Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis for which an effective therapy remains to be established. Our study investigated the therapeutic potential of the suppressor of cytokine signaling 3 (SOCS3), an endogenous inhibitor of intracellular signaling pathways, for treatment of MPM. We infected MPM cells (H226, EHMES-1, MESO-1 and MESO-4) with an adenovirus-expressing SOCS3 (AdSOCS3) to examine the effect of SOCS3 overexpression on MPM cells. SOCS3 overexpression reduced MPM proliferation and induced apoptosis and partial G0/G1 arrest. SOCS3 also inhibited the proliferation of MPM cells via multiple signaling pathways including Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), extracellular signal-regulated kinase (ERK), focal adhesion kinase (FAK) and p53 pathways. Notably, AdSOCS3 treatment inhibited tumor growth in an MPM pleural xenograft model. These findings demonstrate that overexpression of SOCS3 has a potent antitumor effect against MPM both in vitro and in vivo and indicate the potential for clinical use of SOCS3 for MPM treatment. PMID:20949562

  17. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    Directory of Open Access Journals (Sweden)

    Daxenbichler Günter

    2007-07-01

    Full Text Available Abstract Background Suppressor of cytokine signaling (SOCS proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. Methods We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. Results SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015 and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026. In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002. Conclusion This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF

  18. Design of a Module of Data Acquisition and Wireless Transmission Based on ARM7%基于ARM7的数据采集与无线传输模块设计

    Institute of Scientific and Technical Information of China (English)

    郑烨; 张伯虎

    2012-01-01

    This paper proposes a module of data acquisition and wireless transmission based on the ARM7 embedded system.Firstly,we introduce a data acquisition station system based on LPC2220 chip,and shows the design of a wireless transmission module which is composed of the embedded LPC2220 microprocessor and the chip of nRF905.When it works at 868 MHz,the rate of data transmission is 1 Mbit·s-1.The effective transmission radius can reach 800 meters with good stability by using the high gain antenna.The design has the advantages of high precision,high speed and real-time data acquisition and wireless transmission.%提出了一种基于ARM7嵌入式系统的数据采集与无线传输模块的设计方案,实现高精度、快速、实时的数据采集与传输。介绍了基于LPC2220芯片的数据采集系统,给出了由嵌入式LPC2220微处理器和射频收发芯片nRF905组成的无线传输模块设计。当其工作在868 MHz频段时,数据传输速率可达1 Mbit.s-1,采用高增益天线,使得传输距离可达800 m以上,且表现出良好的稳定性。最终实现高精度、快速、实时的数据采集与传输。

  19. Neural-Dynamic-Method-Based Dual-Arm CMG Scheme With Time-Varying Constraints Applied to Humanoid Robots.

    Science.gov (United States)

    Zhang, Zhijun; Li, Zhijun; Zhang, Yunong; Luo, Yamei; Li, Yuanqing

    2015-12-01

    We propose a dual-arm cyclic-motion-generation (DACMG) scheme by a neural-dynamic method, which can remedy the joint-angle-drift phenomenon of a humanoid robot. In particular, according to a neural-dynamic design method, first, a cyclic-motion performance index is exploited and applied. This cyclic-motion performance index is then integrated into a quadratic programming (QP)-type scheme with time-varying constraints, called the time-varying-constrained DACMG (TVC-DACMG) scheme. The scheme includes the kinematic motion equations of two arms and the time-varying joint limits. The scheme can not only generate the cyclic motion of two arms for a humanoid robot but also control the arms to move to the desired position. In addition, the scheme considers the physical limit avoidance. To solve the QP problem, a recurrent neural network is presented and used to obtain the optimal solutions. Computer simulations and physical experiments demonstrate the effectiveness and the accuracy of such a TVC-DACMG scheme and the neural network solver. PMID:26340789

  20. The Design of Data Acquisition Device Based on ARM7 and μC/OS-Ⅱ%基于ARM7内核和μC/OS-Ⅱ的数据采集装置设计

    Institute of Scientific and Technical Information of China (English)

    郑晋平

    2011-01-01

    A data acquisition device is designed in this paper,which adopts LPC2144 chip that based on ARM7 core and uses the advantages of μC/OS-Ⅱ embedded real-time operating system that are better cutting,portability as well as multi-tasking.The use of data acquisition device in the industrial control system is studied in detail.The device can collect,monitor and record kinds of parameters in production field.It is indicated by experiments that this device has the advantages such as low cost,low power consumption,micro-scale technology,and high accuracy,steady running,cost-effective,etc.In view of these advantages this device can be applied widely in kinds of industrial occasions.%基于ARM7内核的LPC2144芯片,利用μC/OS-Ⅱ嵌入式实时操作系统的可裁剪性、可移植性和多任务等特点支持下的数据采集装置,研究了数据采集装置在工业控制系统中的应用,在生产过程中可对生产现场的各种参数进行采集、监视和记录;数据采集是控制系统实现控制的基本条件,只有准确实时的获取对象的运行数据才能实施有效的控制。结果表明ARM7内核+嵌入式操作系统μC/OS-Ⅱ的移植数据采集装置,具有低成本、低功耗、微型化、精度高、运行稳定、性价比高等特点,不仅使其采集性能大幅度提高,而且抗干扰能力和实时性显著增强,可以在各种工业场合中广泛应用。

  1. 基于 ARM 的桌面型3D打印机控制系统设计%Design of desktop 3D printer control system based on ARM

    Institute of Scientific and Technical Information of China (English)

    谭秀腾; 郭小定; 李小龙; 余亮

    2014-01-01

    针对基于单片机为控制器的桌面型3D打印机控制系统中存在的处理速度慢、片外芯片多、电路复杂、打印质量不高等问题,设计了基于ARM为控制器的桌面型3D打印机控制系统。系统采用了NXP公司推出的基于ARM Cortex-M3内核的LPC1768微控制器,用它进行与上位机通信、数据处理、模拟量采集与处理、信号控制,选用A4988专用两相步进电机驱动器实现步进电机细分驱动,简化步进电机细分驱动的设计,行程开关电路采用GK152红外光电传感器。软件采用了PID方式调节加热床、挤出机加热温度。文中论述了控制系统主要硬件电路设计和软件的实现流程,系统测试表明性能良好。%The desktop 3D printer control systems with a sigle-chip controller have problems of slow processing speed, more pieces of outside chips, circuit complexity and poor quality of printing.To solve these problems, a desktop 3D printer control system with an ARM controller is designed.The system employs the LPC1768 microcon-troller based on ARM Cortex-M3 core which is introduced by the NXP and used to communicate with the host com-puter, data processing, analog acquisition and processing, signal control, used A4988 special two-phase stepper motor driver to implement stepper motor subdivision drive and to simplify the drive design for stepping motor.The travel switch circuit adopts GK152 infrared photoelectric sensor.The software adopted PID method in order to adjust the heating temperature of heating bed and extruder.This paper discusses the main hardware circuit design and soft-ware realization process of the control system.The System testing shows good performance.

  2. Brain-Computer Interface-based robotic end effector system for wrist and hand rehabilitation: results of a three-armed randomized controlled trial for chronic stroke

    Directory of Open Access Journals (Sweden)

    Kai Keng eAng

    2014-07-01

    Full Text Available The objective of this study was to investigate the efficacy of an Electroencephalography (EEG-based Motor Imagery (MI Brain-Computer Interface (BCI coupled with a Haptic Knob (HK robot for arm rehabilitation in stroke patients. In this three-arm, single-blind, randomized controlled trial; 21 chronic hemiplegic stroke patients (Fugl-Meyer Motor Assessment (FMMA score 10-50, recruited after pre-screening for MI BCI ability, were randomly allocated to BCI-HK, HK or Standard Arm Therapy (SAT groups. All groups received 18 sessions of intervention over 6 weeks, 3 sessions per week, 90 minutes per session. The BCI-HK group received 1 hour of BCI coupled with HK intervention, and the HK group received 1 hour of HK intervention per session. Both BCI-HK and HK groups received 120 trials of robot-assisted hand grasping and knob manipulation followed by 30 minutes of therapist-assisted arm mobilization. The SAT group received 1.5 hours of therapist-assisted arm mobilization and forearm pronation-supination movements incorporating wrist control and grasp-release functions. In all, 14 males, 7 females, mean age 54.2 years, mean stroke duration 385.1 days, with baseline FMMA score 27.0 were recruited. The primary outcome measure was upper-extremity FMMA scores measured mid-intervention at week 3, end-intervention at week 6, and follow-up at weeks 12 and 24. Seven, 8 and 7 subjects underwent BCI-HK, HK and SAT interventions respectively. FMMA score improved in all groups, but no intergroup differences were found at any time points. Significantly larger motor gains were observed in the BCI-HK group compared to the SAT group at weeks 3, 12 and 24, but motor gains in the HK group did not differ from the SAT group at any time point. In conclusion, BCI-HK is effective, safe, and may have the potential for enhancing motor recovery in chronic stroke when combined with therapist-assisted arm mobilization.

  3. Design of distributed signal synchronization data acquisition system base on ARM9%基于ARM9分布信号同步数据采集系统设计

    Institute of Scientific and Technical Information of China (English)

    邱杰锋; 樊战友; 吴成英

    2011-01-01

    Distribution of signals for synchronous data acquisition,gives a method and process of design of synchronous data acquisition system base on ARM9, analysis and solution the main problems. This paper were introduced by the system's hardware composition and software design. The main function of system is the distribution of various parameters (such as temperature, pressure, sound) at different point in synchronization data acquisition, after the acquisition will be the analog to digital conversion. The biggest advantages of the system is use of the GPS signals control the ADC conversion time in order to realize high-precision synchronization of each acquisition node. Finally,the synchronous accuracy of the system can be achieved within 100ns by experiment.%针对分布信号的同步数据采集,给出了1种基于ARM9的同步数据采集系统的设计方法和过程,并对设计中遇到的主要问题进行了分析和解决.本文从系统的硬件组成、软件设计进行了说明.本系统主要功能是对分布在各个点的各种物理量(如温度、压力、声音)进行同步数据采集,将采集后的数据进行模数转换.系统最大的优点是利用GPS信号控制ADC芯片的转换时间从而实现各个采集节点的高精度同步.最后,通过实验验证了该系统的同步精度可以达到100ns以内.

  4. 基于ARM9与Linux的人脸识别门禁系统设计%The Design of Door Security System for Face Recognition Based on ARM9 & Linux

    Institute of Scientific and Technical Information of China (English)

    刘巍; 汪兆栋

    2015-01-01

    针对现有门禁系统中存在的技术缺陷、维护成本高等问题,本文设计了一套基于 ARM+Linux 的人脸识别门禁系统。该系统采用S3C2410芯片为处理器、IP网络摄像头作为视频采集设备;采用PCA算法进行人脸图像识别,并以识别输出来控制电控锁模块,从而实现人脸识别门禁系统的智能控制。最后,在不同的环境下进行了人脸识别测试,测试结果表明,该系统能准确快速高效地识别人脸,平均识别率高达99%。%Aiming at these problems existing in the current entrance guard system, such as technical shortcomings and expensive maintenance cost, this paper designs a face recognition access system based on ARM9 and Linux. The S3C2410 chip and IP network camera are chosen as processor and video acquisition devices respectively. Then, the facial image recognition is implemented by the PCA algorithm and the electric lock module is controlled by utilizing therecognition output, and thus an intelligent control of face recognition entrance guard system is realized. Finally, sufficient facial recognition tests are performed under different environments, and the test results show that the system can recognize faces accurately, quickly, efficiently, and the average recognition rate reaches up to 99%.

  5. Design and realization of vehicle monitoring terminal based on ARM-Linux system%基于ARM-Linux的车载监控终端设计及实现

    Institute of Scientific and Technical Information of China (English)

    戚微苏; 赵宇; 潘勇

    2012-01-01

    A kind of the vehicle real-time monitoring remote terminal implementation scheme based on ARM-Linux system is proposed. The terminal, which is making use the Linux, Samsung S3C6410 Microprocessor as platform of software and hardware,and expanding the image acquisition,satellite positioning,radio frequency identification, wireless communication and other functional modules on the platform. It can realize the function of monitoring cargo security, providing the current position and image information of the car, achieving real-time communication. This paper focuses on the system hardware design and software design, the composition of the module and its functions in vehicle monitoring system. The experiments show that the terminal system has stable performance and meets the design requirements of function. In practical applications it has a certain value.%提出了一种基于ARM-Linux的车载实时监控远程终端实现方案.该车载监控终端系统以Linux、Samsung S3C6410微处理器作为软硬件平台,并在此硬件平台上扩展了图像采集、GPS定位、射频识别以及GPRS无线传输等功能模块.它可实现监控货物安全、提供车载位置和图像信息,达到实时监控的功能.重点阐述了终端系统的硬件设计及软件设计,各功能模块及其在车载监控终端系统中的功能.经多次实验表明,该终端系统性能稳定,满足设计的功能要求.在实际应用中具有一定的参考价值.

  6. 基于ARM920T的织机电控系统CAN总线接口模块设计%Design of CAN bus interface module based on ARM920T

    Institute of Scientific and Technical Information of China (English)

    刘宜胜; 苏鹏东; 胡旭东; 吴震宇; 王婷婷

    2011-01-01

    A CAN bus interface module was designed to connect the other sub-control systems to realize the real-time, reliable performance requirement of the high speed air-jet weaving machine. The hardware platform was mainly built using embedded microprocessor s3c2440A based on ARM920T kernel of Samsung company and CAN bus controller MCP2515 of Microchip. The software designing was implemented in the Windows CE operating system, including of driver module selection, stream interface functions realization, interrupt handling etc.. The test results show that the design meets the requirements of data transmission speed and reliability.%为实现喷气织机对电控系统通讯实时性、可靠性的要求,设计出一种用于连接织机各子控制系统的CAN总线接口模块.其中,硬件平台主要由三星公司的基于ARM920T内核的嵌入式微处理器s3c2440A及Microchip公司的CAN总线控制器MCP2515进行搭建;软件设计部分包括了WinCE操作系统下驱动选型、流接口函数实现、中断处理等内容.实验结果表明,该设计可以满足系统对数据传输的快速性和可靠性的要求.

  7. 基于ARM9的液晶驱动设计与μC/GUI移植研究%LCD driver design and transplant of μC/GUI based on ARM9

    Institute of Scientific and Technical Information of China (English)

    李彬; 纪常伟

    2011-01-01

    In process of embedded systems development, graphical user interface (GUI) is an important way for people to interact with the computer. As an important device for GUI, LCD was widely used in intelligent instruments and high - end embedded devices. This article describes the LCD controller in S3C2440 based on ARM920T core, interface circuit of LCD and its corresponding driver development. On this basis, μC/GUI which is a very excellent package of graphical user interface was transplanted in this system. The satisfactory result is attained on LCD screen by running examples of μC/GUI. The interface circuit and driver design for LCD and transplant of μC/GUI are proved reasonable and stable.%在嵌入式系统开发设计中,图形用户界面(GUI)是人与计算机进行交互的重要方式,液晶屏作为GUI的重要设备,在智能仪器仪表与高端嵌入式设备中得到广泛运用.文中介绍了基于ARM920T内核的芯片S3C2440内部LCD控制器以及LCD接口电路设计和相应驱动程序开发.并在此基础上移植了一种非常优秀的图形用户接口软件包μC/GUI.经过测试与μC/GUI实例运行,在液晶屏幕上得到了满意的显示效果,证明了液晶显示部分硬件接口、驱动设计以及μC/GUI移植的合理性与稳定性.

  8. Design and realization of the angular displacement measuring system based on embedded ARM%基于ARM的角位移测量系统研制

    Institute of Scientific and Technical Information of China (English)

    郑丰翔; 朱蕴璞

    2011-01-01

    为了实现角位移的高精度测量,研制了一种基于ARM的角位移测量系统.该系统以ARM9处理器S3C2410为核心,一方面控制旋转编码器采集角位移信号;另一方面通过USB接口与计算机通信,实现命令与数据的传输.在上位机利用C#编写应用程序,绘制并显示角位移、角速度和角加速度曲线.通过实验证明,该系统能快速准确对旋转体运行状况进行检测.%In order to achieve high-precision measurement ofangular displacement,a system based on embedded ARM isdesigned. The ARM9 S3C2410 embedded microprocessor is taken as the core. On the one hand, this kernel is used tocontrol rotary encoder to collect signals; on the other hand, its USB interface is used to transfer command and data toPC. Write program with C # ,and protract the angular acceleration, the angular velocity and the angular displacementcurve. The experimental results show that the system can detect the running status of rotating object quickly andaccurately.

  9. Balance Maintenance in High-Speed Motion of Humanoid Robot Arm-Based on the 6D Constraints of Momentum Change Rate

    Directory of Open Access Journals (Sweden)

    Da-song Zhang

    2014-01-01

    Full Text Available Based on the 6D constraints of momentum change rate (CMCR, this paper puts forward a real-time and full balance maintenance method for the humanoid robot during high-speed movement of its 7-DOF arm. First, the total momentum formula for the robot’s two arms is given and the momentum change rate is defined by the time derivative of the total momentum. The author also illustrates the idea of full balance maintenance and analyzes the physical meaning of 6D CMCR and its fundamental relation to full balance maintenance. Moreover, discretization and optimization solution of CMCR has been provided with the motion constraint of the auxiliary arm’s joint, and the solving algorithm is optimized. The simulation results have shown the validity and generality of the proposed method on the full balance maintenance in the 6 DOFs of the robot body under 6D CMCR. This method ensures 6D dynamics balance performance and increases abundant ZMP stability margin. The resulting motion of the auxiliary arm has large abundance in joint space, and the angular velocity and the angular acceleration of these joints lie within the predefined limits. The proposed algorithm also has good real-time performance.

  10. Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia

    Directory of Open Access Journals (Sweden)

    Deniz Torun

    2013-03-01

    Full Text Available OBJECTIVE: Myeloproliferative neoplasms (MPNs like essential thrombocythemia (ET, polycythemia vera (PV, and primary myelofibrosis (PMF are acquired clonal hematopoietic stem cell disorders and originate from a multipotent hematopoietic stem cell. The SOCS1 and SOCS3 genes are negative regulators of the JAK/STAT signal pathway. In this study we investigate the promoter methylation of these genes in the pathogenesis of MPNs and secondary erythrocytosis/thrombocythemia. METHODS: Promoter methylation of SOCS1 and SOCS3 genes was analyzed with methylation-specific PCR. PCR products were analyzed by agarose gel electrophoresis. RESULTS: No disease-specific CpG island methylation of SOCS1 was observed. Hypermethylation of the SOCS3 promoter was identified in 5 out of 19 (26.3% PV cases, 2 out of 21 (9.5% ET cases, 1 out of 5 (20% PMF cases, and 9 out of 42 (21.4% cases of secondary erythrocytosis/thrombocythemia. CONCLUSION: The results revealed that promoter methylation of the SOCS3 gene suggests a possible role for SOCS3 methylation in the pathogenesis of MPNs and secondary erythrocytosis/thrombocythemia.

  11. Interferon alpha antagonizes STAT3 and SOCS3 signaling triggered by hepatitis C virus.

    Science.gov (United States)

    Zhao, Lan-Juan; He, Sheng-Fei; Wang, Wen; Ren, Hao; Qi, Zhong-Tian

    2016-04-01

    We aimed to investigate regulation of signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) by interferon alpha (IFN-α) and to analyze the relationship between STAT3 and SOCS3 during hepatitis C virus (HCV) infection. Changes in STAT3 and SOCS3 were analyzed at both mRNA and protein levels in human hepatoma cells infected with HCV (J6/JFH1). At 72h of HCV infection, STAT3 expression was decreased with sustained phosphorylation, and IFN-α increased such decrease and phosphorylation. HCV increased SOCS3 expression, while IFN-α impaired such increase, indicating different regulation of STAT3 and SOCS3 by IFN-α. IFN-α-induced expression and phosphorylation of upstream kinases of the JAK/STAT pathway, Tyk2 and Jak1, were suppressed by HCV. Moreover, knockdown of STAT3 by RNA interference led to decreases in HCV RNA replication and viral protein expression, without affecting either the expression of Tyk2 and Jak1 or the SOCS3 induction in response to IFN-α. These results show that IFN-α antagonizes STAT3 and SOCS3 signaling triggered by HCV and that STAT3 regulation correlates inversely with SOCS3 induction by IFN-α, which may be important in better understanding the complex interplay between IFN-α and signal molecules during HCV infection. PMID:26945996

  12. The 2010 Standard Occupational Classification (SOC): A Classification System Gets an Update

    Science.gov (United States)

    Emmel, Alissa; Cosca, Theresa

    2010-01-01

    Making sense of occupational data isn't always easy. But the task is less daunting when the data are well organized. For Federal occupational statistics, the Standard Occupational Classification (SOC) system establishes that organization. And a recent revision to the SOC means that the data will be current, in addition to being well organized. The…

  13. Quantification of SOC and Clay Content Using Visible Near-Infrared Reflectance–Mid-Infrared Reflectance Spectroscopy With Jack-Knifing Partial Least Squares Regression

    DEFF Research Database (Denmark)

    Peng, Yi; Knadel, Maria; Gislum, René;

    2014-01-01

    A total of 125 soil samples were collected from a Danish field varying in soil texture from sandy to loamy. Visible near-infrared reflectance (Vis-NIR) and mid-infrared reflectance (MIR) spectroscopy combined with chemometric methods were used to predict soil organic carbon (SOC) and clay contents....... The main objective of this study was to find the best model for predicting SOC and clay content in the sampled field using Vis-NIR, MIR, and the combination of Vis-NIR and MIR and using different model development techniques. The secondary objectives were (i) to use iterations of calculation to find...... the optimal number of replicates for MIR measurements based on the root mean square error of cross validation (RMSECV) and (ii) to apply partial least squares regression in combination with jackknifing (JK) to identify the most important part of spectral variables and the best model for predicting SOC...

  14. Power optimization and performance improvement for embedded Ethernet SOC

    Institute of Scientific and Technical Information of China (English)

    ZHENG Zhao-xia; ZOU Lian-ying; GAO Jun

    2008-01-01

    Information appliance is the combination of traditional home appliances and the internet technology. In this article, an Ethernet controller system-on-chip (SOC) solution for information appliances is presented. To achieve high performance, the embedded 8 bits 8051 micro control unit (MCU) is optimized by an independent instruction bus and a data bus. Besides, a two-stage pipeline feature is added. Compared with the existing 8051 core, the enhanced one-cycle MCU offers ten times improvement in instruction execution efficiency. Mean- while, the performance of media access control (MAC) circuit is greatly improved by adopting various techniques such as direct memory access (DMA) control, paging strategy, etc. To reduce the power consumption, clock gating, low power supply, and multi-working-clock are adopted. Moreover, to achieve rapid data communication in different clock frequency circuits, a simple ping-pong first in first out (FIFO) circuit is realized. The chip is implemented using TSMC 0.25 μm two-poly four-metal mixed signal complementary metal oxide semiconductor (CMOS) technology. Its die area is mm. The test results show that the maximum throughput of Ethernet packets can reach 7 Mb/s while the power consumption is rather low-the working current is just about 200 mA.

  15. Verification and Diagnosis Infrastructure of SoC HDL-model

    CERN Document Server

    Hahanov, Vladimir; Litvinova, Eugenia; Chumachenko, Svetlana

    2012-01-01

    This article describes technology for diagnosing SoC HDL-models, based on transactional graph. Diagnosis method is focused to considerable decrease the time of fault detection and memory for storage of diagnosis matrix by means of forming ternary relations in the form of test, monitor, and functional component. The following problems are solved: creation of digital system model in the form of transaction graph and multi-tree of fault detection tables, as well as ternary matrices for activating functional components in tests, relative to the selected set of monitors; development of a method for analyzing the activation matrix to detect the faults with given depth and synthesizing logic functions for subsequent embedded hardware fault diagnosing.

  16. A new universal gate for low power SoC applications

    Indian Academy of Sciences (India)

    M Geetha Priya; K Baskaran

    2013-08-01

    This paper formulates a new design technique for an area and energy efficient Universal NAND gate. The proposed robust three transistors (3T) based NAND gate is just as effective for dynamic power control in CMOS VLSI circuits for System on Chip (SoC) applications. The 3T NAND gate is intuitively momentous and lead to better performance measures in terms of dynamic power, reduced area and high speed while maintaining comparable performance than the other available NAND gate logic structures. Simulation tests were performed by employing standard Berkeley Predictive Technology Model (BPTM) 22 nm, 45 nm and 90 nm process technologies. The experiment and simulation results show that, the proposed 3T NAND gate effectively outperforms the basic CMOS NAND gate with excellent driving capability and signal integrity with exact output logic levels.

  17. Mixed-signal methodology guide advanced methodology for AMS IP and SOC design, verification and implementation

    CERN Document Server

    Chen, Jess; Mar, Monte F; Nizic, Mladen; Bailey, Brian

    2012-01-01

    This Book, The Mixed-Signal Methodology Guide: Advanced Methodology For Ams Ip And Soc Design, Verification, And Implementation Provides A Broad Overview Of The Design, Verification And Implementation Methodologies Required For Today's Mixed-Signal Designs. The Book Covers Mixed-Signal Design Trends And Challenges, Abstraction Of Analog Using Behavioral Models, Assertion-Based Metric-Driven Verification Methodology Applied On Analog And Mixed-Signal And Verification Of Low Power Intent In Mixed-Signal Design. It Also Describes Methodology For Physical Implementation In Context Of Concurrent Mixed-Signal Design And For Handling Advanced Node Physical Effects. The Book Contains Many Practical Examples Of Models And Techniques. The Authors Believe It Should Serve As A Reference To Many Analog, Digital And Mixed-Signal Designers, Verification, Physical Implementation Engineers And Managers In Their Pursuit Of Information For A Better Methodology Required To Address The Challenges Of Modern Mixed-Signal Design.

  18. Algorithm & SoC design for automotive vision systems for smart safe driving system

    CERN Document Server

    Shin, Hyunchul

    2014-01-01

    An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

  19. Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine.

    Science.gov (United States)

    Bozorgzadeh, Bardia; Schuweiler, Douglas R; Bobak, Martin J; Garris, Paul A; Mohseni, Pedram

    2016-06-01

    This paper presents a 3.3×3.2 mm(2) system-on-chip (SoC) fabricated in AMS 0.35 μm 2P/4M CMOS for closed-loop regulation of brain dopamine. The SoC uniquely integrates neurochemical sensing, on-the-fly chemometrics, and feedback-controlled electrical stimulation to realize a "neurochemostat" by maintaining brain levels of electrically evoked dopamine between two user-set thresholds. The SoC incorporates a 90 μW, custom-designed, digital signal processing (DSP) unit for real-time processing of neurochemical data obtained by 400 V/s fast-scan cyclic voltammetry (FSCV) with a carbon-fiber microelectrode (CFM). Specifically, the DSP unit executes a chemometrics algorithm based upon principal component regression (PCR) to resolve in real time electrically evoked brain dopamine levels from pH change and CFM background-current drift, two common interferents encountered using FSCV with a CFM in vivo. Further, the DSP unit directly links the chemically resolved dopamine levels to the activation of the electrical microstimulator in on-off-keying (OOK) fashion. Measured results from benchtop testing, flow injection analysis (FIA), and biological experiments with an anesthetized rat are presented. PMID:26390501

  20. Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24

    Institute of Scientific and Technical Information of China (English)

    Xin Cao; Ruicheng Wei; Xinran Liu; Yan Zeng; Hongling Huang; Miao Ding; Kangjian Zhang; Xin-Yuan Liu

    2011-01-01

    The combination of gene therapy and virotherapy for cancer treatment has received close attention and has become a trend in the field of cancer biotherapy.A strategy called 'Cancer Targeting Gene-Viro-Therapy' (CTGVT) or 'Gene Armed Oncolytic Viral Therapy'(GAOVT) has been proposed,in which an antitumor gene is inserted into an oncolytic viral vector.In our previous study,a dual-regulated oncolytic adenovirus with enhanced safety for normal cells and strict liver cancertargeting ability,designated Ad·enAFP· E1A· E1 B (A55)(briefly Ad·enAFP·D55),was successfully constructed. In the current work,interleukin-24 (IL-24) and suppressor of cytokine signaling 3 (SOCS3) genes were packaged into Ad·enAFP·D55.The new constructs,Ad·enAFP·D55-(IL-24) and Ad·enAFP·D55-(SOCS3),showed improved tumoricidal activity in hepatoma cell lines compared with the oncolytic viral vector Ad·enAFP·D55.The coadministrationofAd · enAFP· D55-(IL-24)and Ad·enAFP·D55-(SOCS3) showed much better antitumor effect than Ad·enAFP·D55-(IL-24) or Ad·enAFP·D55-(SOCS3) alone both in vitro and in a nude mouse xenograft model.Moreover,our results also showed that blockade of the Jak/Stat3 pathway by Ad·enAFP·D55-(SOCS3) infection in HuH-7 cells could down-regulate some anti-apoptosis proteins,such as XIAP,Bcl-xL,and survivin,whichmightsensitizethecellsto Ad·enAFP·D55-(IL-24)-induced apoptosis.These results indicate that co-administration of Ad·enAFP·D55-(IL-24) and Ad·enAFP·D55-(SOCS3) may serve as a candidate therapeutic approach for the treatment of liver cancer.

  1. What are the effects of agricultural management on soil organic carbon (SOC) stocks?

    DEFF Research Database (Denmark)

    Söderström, Bo; Hedlund, Katarina; Jackson, Louise E.;

    2014-01-01

    Changes in soil organic carbon (SOC) stocks significantly influence the atmospheric C concentration. Agricultural management practices that increase SOC stocks thus may have profound effects on climate mitigation. Additional benefits include higher soil fertility since increased SOC stocks improve...... the physical and biological properties of the soil. Intensification of agriculture and land-use change from grasslands to croplands are generally known to deplete SOC stocks. The depletion is exacerbated through agricultural practices with low return of organic material and various mechanisms, such as...... oxidation/mineralization, leaching and erosion. However, a systematic review comparing the efficacy of different agricultural management practices to increase SOC stocks has not yet been produced. Since there are diverging views on this matter, a systematic review would be timely for framing policies not...

  2. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Brender, C; Nielsen, M; Kaltoft, K;

    2001-01-01

    A characteristic feature of neoplastic transformation is the loss of external control by cytokines and extracellular matrix of cellular differentiation, migration, and mitogenesis. Because suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling, it...... has been hypothesized that an aberrant SOCS expression plays a role in neoplastic transformation. This study reports on a constitutive SOCS-3 expression in cutaneous T-cell lymphoma (CTCL) cell lines. SOCS-3 protein is constitutively expressed in tumor cell lines (but not in nonmalignant T cells......) obtained from affected skin from a patient with mycosis fungoides (MF) and from peripheral blood from a patient with Sezary syndrome (SS). In contrast, constitutive SOCS-3 expression is not found in the leukemic Jurkat T-cell line, the MOLT-4 acute lymphoblastic leukemia cell line, and the monocytic...

  3. A passivity based control methodology for flexible joint robots with application to a simplified shuttle RMS arm

    Science.gov (United States)

    Sicard, Pierre; Wen, John T.

    1991-01-01

    The main goal is to develop a general theory for the control of flexible robots, including flexible joint robots, flexible link robots, rigid bodies with flexible appendages, etc. As part of the validation, the theory is applied to the control law development for a test example which consists of a three-link arm modeled after the shoulder yaw joint of the space shuttle remote manipulator system (RMS). The performance of the closed loop control system is then compared with the performance of the existing RMS controller to demonstrate the effectiveness of the proposed approach. The theoretical foundation of this new approach to the control of flexible robots is presented and its efficacy is demonstrated through simulation results on the three-link test arm.

  4. The Development of a General Purpose ARM-based Processing Unit for the TileCal sROD

    CERN Multimedia

    Cox, Mitchell A

    2014-01-01

    The Large Hadron Collider at CERN generates enormous amounts of raw data which present a serious computing challenge. After planned upgrades in 2022, the data output from the ATLAS Tile Calorimeter will increase by 200 times to 41 Tb/s! ARM processors are common in mobile devices due to their low cost, low energy consumption and high performance. It is proposed that a cost-effective, high data throughput Processing Unit (PU) can be developed by using several consumer ARM processors in a cluster configuration to allow aggregated processing performance and data throughput while maintaining minimal software design difficulty for the end-user. This PU could be used for a variety of high-level functions on the high-throughput raw data such as spectral analysis and histograms to detect possible issues in the detector at a low level. High-throughput I/O interfaces are not typical in consumer ARM System on Chips but high data throughput capabilities are feasible via the novel use of PCI-Express as the I/O interface t...

  5. The Development of a General Purpose ARM-based Processing Unit for the ATLAS TileCal sROD

    CERN Document Server

    Cox, Mitchell Arij; The ATLAS collaboration; Mellado Garcia, Bruce Rafael

    2015-01-01

    The Large Hadron Collider at CERN generates enormous amounts of raw data which present a serious computing challenge. After Phase-II upgrades in 2022, the data output from the ATLAS Tile Calorimeter will increase by 200 times to 41 Tb/s! ARM processors are common in mobile devices due to their low cost, low energy consumption and high performance. It is proposed that a cost-effective, high data throughput Processing Unit (PU) can be developed by using several consumer ARM processors in a cluster configuration to allow aggregated processing performance and data throughput while maintaining minimal software design difficulty for the end-user. This PU could be used for a variety of high-level functions on the high-throughput raw data such as spectral analysis and histograms to detect possible issues in the detector at a low level. High-throughput I/O interfaces are not typical in consumer ARM System on Chips but high data throughput capabilities are feasible via the novel use of PCI-Express as the I/O interface ...

  6. Suppressor of cytokine signaling (SOCS genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.

    Directory of Open Access Journals (Sweden)

    Moon-Hong Kim

    Full Text Available Suppressor of cytokine signaling (SOCS family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

  7. Power Integrity Analysis of ARM11 Core Board Based on FEM%基于有限元方法的ARM11核心板电源完整性分析

    Institute of Scientific and Technical Information of China (English)

    沈敏; 吴明赞; 李竹

    2014-01-01

    ARM11 core board belongs to high-speed circuit board,and during the design we need to reduce input impedance of PDN ( Power Delivery Network ) to improve power integrity. SSN ( Simultaneous Switching Noise ) produced by 10 transistors and DC/AC Characteristics of PDN before and after adjustment are simulated based on FEM,the simulation results indicate that chip power voltage fluctuation reaches 7. 9% when 10 transistors switch simultaneously;DC voltage of 1. 2 V PDN is increased from 1. 17 V to 1. 18 V,current density of PDN is reduced integrally;Resonance phenomenon of PDN is weakened at the frequency of 397 MHz;So chip power voltage hasn't satisfied the requirements when 10 transistors switch simultaneously,after PDN is adjusted,the input impedance and voltage fluctuation of PDN is reduced finally.%ARM11核心板属于高速电路板,在设计中需要降低电源配送网络( Power Delivery Network)的输入阻抗来提高电源完整性。基于有限元方法对10个晶体管产生的同步开关噪声( Simultaneous Switching Noise)、调整前后PDN的直流/交流特性进行仿真,仿真结果表明:10个晶体管同时开关时芯片电源电压波动达7.9%;1.2 V PDN的直流电压从1.17 V增加到1.18 V,PDN的电流密度整体得到降低;在397 MHz谐振频率处PDN的谐振现象得到减弱;因此当达到10个晶体管同时开关时芯片电源电压已不满足要求,在对PDN调整后最终降低了PDN的输入阻抗和电压波动。

  8. Relationship between distal radius fracture malunion and arm-related disability: A prospective population-based cohort study with 1-year follow-up

    Directory of Open Access Journals (Sweden)

    Dahlin Lars B

    2011-01-01

    Full Text Available Abstract Background Distal radius fracture is a common injury and may result in substantial dysfunction and pain. The purpose was to investigate the relationship between distal radius fracture malunion and arm-related disability. Methods The prospective population-based cohort study included 143 consecutive patients above 18 years with an acute distal radius fracture treated with closed reduction and either cast (55 patients or external and/or percutaneous pin fixation (88 patients. The patients were evaluated with the disabilities of the arm, shoulder and hand (DASH questionnaire at baseline (concerning disabilities before fracture and one year after fracture. The 1-year follow-up included the SF-12 health status questionnaire and clinical and radiographic examinations. Patients were classified into three hypothesized severity categories based on fracture malunion; no malunion, malunion involving either dorsal tilt (>10 degrees or ulnar variance (≥1 mm, and combined malunion involving both dorsal tilt and ulnar variance. Multivariate regression analyses were performed to determine the relationship between the 1-year DASH score and malunion and the relative risk (RR of obtaining DASH score ≥15 and the number needed to harm (NNH were calculated. Results The mean DASH score at one year after fracture was significantly higher by a minimum of 10 points with each malunion severity category. The RR for persistent disability was 2.5 if the fracture healed with malunion involving either dorsal tilt or ulnar variance and 3.7 if the fracture healed with combined malunion. The NNH was 2.5 (95% CI 1.8-5.4. Malunion had a statistically significant relationship with worse SF-12 score (physical health and grip strength. Conclusion Malunion after distal radius fracture was associated with higher arm-related disability regardless of age.

  9. Mapping SOC in a river catchment by integrating laboratory spectra wavelength with remote sensing spectra

    DEFF Research Database (Denmark)

    Peng, Yi; Xiong, Xiong; Knadel, Maria;

    There is potential to use soil ·-proximal and remote sensing derived spectra concomitantly to develop soil organic carbon (SOC) models. Yet mixing spectral data from different sources and technologies to improve soil models is still in its infancy. The objective of this study was to incorporate...... soil spectral features indicative of SOC from laboratory visible near-infrared reflectance (vis-NlR) spectra and incorporate them with remote sensing (RS) images to improve predictions of top SOC in the Skjem river catchment, Denmark. The secondary objective was to improve prediction results by...

  10. Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

    DEFF Research Database (Denmark)

    Eriksen, Karsten W; Woetmann, Anders; Skov, Lone;

    2010-01-01

    , we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-alpha and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN......-alpha-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN...

  11. Suppressors of Cytokine Signaling (SOCS) in T cell differentiation, maturation, and function

    OpenAIRE

    Douglas C Palmer; Restifo, Nicholas P

    2009-01-01

    Cytokines are key modulators of T cell biology but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins comprised of eight members, SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of CD4+ T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8+ T cells from naïve to “stem-cell memory” (Tscm), central memory (Tcm), and effector memory (Tem) states, and the activation of these lympho...

  12. Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2) Polymorphism in Different Dog Breeds

    OpenAIRE

    Martina Miluchová; Michal Gábor; Anna Trakovická; Peter Beke

    2011-01-01

    SOCS2 is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. The aim of the paper was to identify of suppressor of cytokine signaling 2 gene (SOCS2) polymorphism in different dog breeds. The material involved 77 dogs from 14 different breeds. Canine genomic DNA was isolated from saliva by modified method with using DNAzol® (Molecular Research Center) and linear polyacrylamide (LPA) carrier and from blood by using N...

  13. Most Correlated Arms Identification

    OpenAIRE

    Liu, Che-Yu; Bubeck, Sébastien

    2014-01-01

    We study the problem of finding the most mutually correlated arms among many arms. We show that adaptive arms sampling strategies can have significant advantages over the non-adaptive uniform sampling strategy. Our proposed algorithms rely on a novel correlation estimator. The use of this accurate estimator allows us to get improved results for a wide range of problem instances.

  14. An event-based vibration control for a two-link flexible robotic arm: Numerical and experimental observations

    Science.gov (United States)

    Özer, Abdullah; Eren Semercigil, S.

    2008-06-01

    Flexible robot manipulators have numerous advantages over their rigid counterparts. They have increased payload-to-weight ratio, they run at higher speeds, use less energy and smaller actuators, and they are safer during interaction with their environments. On the other hand, light design combined with external effects result in components which can oscillate with excessive amplitudes. These oscillations cause deviation from the desired path and long idle periods between tasks in order to perform the intended operation safely and accurately. This paper is on an investigation into the effectiveness of a vibration control technique for a two-link flexible robotic arm. Variable stiffness control (VSC) technique is used to control the excessive oscillations. Owing to its dissipative nature, the technique is stable, it is relatively insensitive to significant parameter changes and suitable to be implemented on existing robots. This research considers that the source of the flexibility is either the joints or the links or both. Simulation results of the response of the arm are presented to show the versatility of the proposed control technique. Experiments are performed on a laboratory prototype and the results are presented to test the validity of simulations.

  15. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias;

    2012-01-01

    in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice...

  16. Design of audio data acquisition system based on ARM and DSP%基于ARM与DSP的声频数据采集系统设计

    Institute of Scientific and Technical Information of China (English)

    周静雷; 江浩; 乔站仙

    2012-01-01

    结合1个基于ARM与DSP双核架构的声频数据采集系统的开发,介绍了ARM和DSP之间基于HPI通信的接口设计以及A/D、D/A接口设计,说明了接口工作原理及相关配置.提出了一种声频数据采集方案,利用ARM实现控制与人机交互,用DSP做信号处理,给出了数据采集的系统框图和软件流程图.该方案可充分利用DSP的McASP接口实现高精度A/D、D/A转换,利用HPI主机并行接口实现ARM与DSP之间的快速数据传输,从而实现海量声频数据流的高效、实时传输.%According to an audio data acquisition system,this paper introduces the communication interface design on the basis of HPI between ARM and DSP,and A/CD/A converter design,describes the operating principle of interfaces and relevant configuration. A method of audio data acquisition is presented, control is based on ARM, DSP takes charge of signal processing,it provides the system chart of data acquisition and software flow chart. This design scheme can take full advantage of McASP interface to achieve high-precision AD & DA converter,and HPI interface is used to realize high speed data transfer between ARM and DSP, thereby achieving efficient and real-time transmission of huge amounts of audio data stream.

  17. Modal Analysis of the Harvesting Robot Arm Based on ANSYS Workbench%基于 ANSYS Workbench 的采摘机器人臂架模态分析

    Institute of Scientific and Technical Information of China (English)

    杨志敏; 周健; 李立君; 程学良

    2013-01-01

    In order to improve the harvesting efficiency of forest-fruit, the structure characteristics of the Harvesting Ro-bot Arm was introduced , the harvesting robot should have more reasonable structure and dynamic performance .Based on the modal analysis theory , a finite element model of the harvesting robot arm was established by utilizing the software of ANSYS Workbench .Three kinds of typical pose were selected , further more , the preceding six steps natural frequency and mode were obtained .Last but not at least , the weak parts of the robot arm were found out and relative improving su ggestion was put forward , which laid foundation for the optimized design .%介绍了采摘机器人臂架的结构特征;为了提高林果的采收效率,使采摘机器人具有更合理的结构和动态特性,以模态分析理论为基础,应用有限元分析软件ANSYSWorkbench,建立了采摘机器人臂架的有限元模型;选取臂架的3种典型位姿,得出了其在不同位姿下的前6阶固有频率和振型,找出薄弱环节,提出了相应的改进方案,为臂架的进一步优化设计打下基础。

  18. A State of the Art Review- Methods to Evaluate Electrical Performance of Composite Cross-arms and Composite-based Pylons

    DEFF Research Database (Denmark)

    Wang, Qian; Bak, Claus Leth; Silva, Filipe Miguel Faria da;

    2016-01-01

    A novel uni-body composite pylon has been proposed for 400 kV transmission lines with advantages of compacted size, friendly looking and cost competitiveness. As its configuration is quite different from the traditional lattice pylon, its electrical performance needs in-depth investigation and...... evaluation, for which electrical testing methods are essential. However, as research on composite-based pylons is still in initial stage, leaving international standards and theoretical analysis on this topic very limited, effective testing methods to evaluate the fully composite pylon’s electrical...... performance need to be studied. This paper sums up experience and key advances on testing methods to evaluate electrical performance of composite cross-arms and composite-based pylons. Based on state of the art review, several feasible testing methods that can be used to verify the feasibility of the novel...

  19. Changing patterns of US arms transfers

    Energy Technology Data Exchange (ETDEWEB)

    Salomone, M.D.

    1985-01-01

    The thesis has three purposes. First is to explore the changing patterns of US arms transfers from Fiscal Year 1950 (FY 1950) through Fiscal Year 1980 (FY 1980). Second, is to describe and assess the decision-making process for arms transfers within the US Government. Third is to examine and critique the conventional wisdom concerning US arms transfers, to support that wisdom, or to offer an alternate empirically supported view. The conventional wisdom about US arms transfer is that they have been rising at an alarming rate, and that this is the result of an arms transfer decision-making process which is out of control. This belief is founded on an empirically based proposition that arms transfers have been rising at an alarming rate. However, this proposition has never been empirically validated. To explore this conventional wisdom, the author establishes the historical, political and defense policy contexts for US arms transfers over the period FY 1950 through FY 1980. The author critiques the conventional wisdom about US arms transfers, analyzes the many ways that arms transfers have been measured, and explores the impediments to accurate measurement and assessment of the phenomenon.

  20. The arms race control

    International Nuclear Information System (INIS)

    Written in 1961, this paper presents the content of a book entitled 'The arms race control' where the author outlined the difference between disarmament and arms control, described the economic and moral role of arms race, the importance of force balance for international security. He wandered whether arms control could ensure this balance and whether nuclear balance meant force balance. Force balance then appears to be a precarious and unsteady component of international security. He commented the challenges of disarmament, recalled some arguments for a nuclear disarmament. Then he discussed what would be an arms control with or without disarmament (either nuclear or conventional)

  1. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

    DEFF Research Database (Denmark)

    Beck Jørgensen, Sebastian; O'Neill, Hayley M; Sylow, Lykke;

    2013-01-01

    Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin...... of hyperinsulinemia and insulin resistance because of enhanced skeletal muscle insulin receptor substrate 1 (IRS1) and Akt phosphorylation that resulted in increased skeletal muscle glucose uptake. These data indicate that skeletal muscle SOCS3 does not play a critical role in regulating muscle development or energy...... expenditure, but it is an important contributing factor for inhibiting insulin sensitivity in obesity. Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance....

  2. Scanning ARM Cloud Radar Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Widener, K; Bharadwaj, N; Johnson, K

    2012-06-18

    The scanning ARM cloud radar (SACR) is a polarimetric Doppler radar consisting of three different radar designs based on operating frequency. These are designated as follows: (1) X-band SACR (X-SACR); (2) Ka-band SACR (Ka-SACR); and (3) W-band SACR (W-SACR). There are two SACRs on a single pedestal at each site where SACRs are deployed. The selection of the operating frequencies at each deployed site is predominantly determined by atmospheric attenuation at the site. Because RF attenuation increases with atmospheric water vapor content, ARM's Tropical Western Pacific (TWP) sites use the X-/Ka-band frequency pair. The Southern Great Plains (SGP) and North Slope of Alaska (NSA) sites field the Ka-/W-band frequency pair. One ARM Mobile Facility (AMF1) has a Ka/W-SACR and the other (AMF2) has a X/Ka-SACR.

  3. A step toward 'plug and play' robotics with SoC technology

    DEFF Research Database (Denmark)

    Sørensen, Anders Stengaard; Falsig, Simon; Ugilt, Rolf

    p, li { white-space: pre-wrap; } This article describe our progress toward simplifying and streamlining the low level systems integration of experimental robots, combining a System on Chip (SoC) approach with conventional modular approaches. The combined approach has increased flexibility, improved...... the embedded integration, and decreased the complexity of programming, compared to conventional modular approaches. We show the impact of the SoC approach in a simple demonstration and teaching model of a walking robot....

  4. A new class of energy based control laws for revolute robot arms - Tracking control, robustness enhancement and adaptive control

    Science.gov (United States)

    Wen, John T.; Kreutz, Kenneth; Bayard, David S.

    1988-01-01

    A class of joint-level control laws for all-revolute robot arms is introduced. The analysis is similar to the recently proposed energy Liapunov function approach except that the closed-loop potential function is shaped in accordance with the underlying joint space topology. By using energy Liapunov functions with the modified potential energy, a much simpler analysis can be used to show closed-loop global asymptotic stability and local exponential stability. When Coulomb and viscous friction and model parameter errors are present, a sliding-mode-like modification of the control law is proposed to add a robustness-enhancing outer loop. Adaptive control is also addressed within the same framework. A linear-in-the-parameters formulation is adopted, and globally asymptotically stable adaptive control laws are derived by replacing the model parameters in the nonadaptive control laws by their estimates.

  5. Networking remote control of nuclear instruments based on multi-channel serial communication in ARM-linux

    International Nuclear Information System (INIS)

    Measurement and control of nuclear instruments in particular environment is not suitable for on-site direct operation. In addition, monitor of nuclear instruments should be multi-point binding and continuous monitoring. With those characteristics, the solution for remote control and nuclear instruments networking by multi-channel serial communication interface under ARM-Linux is proposed. On the basis of practical application, mode of hardware connection for multi-channel serial interface is analyzed. Moreover, the paper also describes in detail serial port initialization and multi-port serial programming. Finally experiments prove that multi-channel serial communication can improve data transmission rate of nuclear instruments, but also achieve remote monitor and centralized management of nuclear instruments networking. (authors)

  6. Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells

    Czech Academy of Sciences Publication Activity Database

    Fojtová, Miloslava; Boudný, V.; Kovařík, Aleš; Lauerová, L.; Adámková, L.; Součková, K.; Jarkovský, J.; Kovařík, J.

    2007-01-01

    Roč. 97, č. 2 (2007), s. 231-237. ISSN 0007-0920 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : SOCS protein * malignant melanoma * interferon resistance Subject RIV: BO - Biophysics Impact factor: 4.635, year: 2007

  7. Optimization-Based Design of a Small Pneumatic-Actuator-Driven Parallel Mechanism for a Shoulder Prosthetic Arm with Statics and Spatial Accessibility Evaluation

    Directory of Open Access Journals (Sweden)

    Masashi Sekine

    2013-07-01

    Full Text Available Human arms undertake most tasks in the activities of daily living (ADLs. When designing shoulder prostheses for high‐level upper‐limb amputees, we should consider not only how to realize high degrees of freedom under weight and shape constraints but also the user’s individual task space in daily life. An appropriate mechanical structure that can make full use of state‐of‐the‐art actuators and a scheme to optimize the structure’s configuration to match users’ spatial access and manipulability requirements are essential. In our previous research, a small pneumatic‐actuator‐driven parallel mechanism was studied as a shoulder prosthetic arm. In this paper, a systematic procedure is proposed to design the mechanism for a shoulder prosthesis considering force and spatial accessibility. This procedure includes ADL measurements to obtain the task spaces for individual subjects, indexes to evaluate the force and spatial accessibility and an optimization process based on kinematic and statics models. With this approach, the parallel mechanism was optimized for one important ADL task group, considering the trade‐off between its required force and working space. Moreover, it was confirmed that the proposed design procedure could find solutions for various spatial specifications. That is, the approach could be used for individualized shoulder prosthesis design.

  8. 基于ARM的平板电脑硬件平台设计%Design of tablet PC hardware platform based on ARM

    Institute of Scientific and Technical Information of China (English)

    王茜

    2012-01-01

    为了给学生搭建专业实践的平台,设计了基于ARM的平板电脑硬件平台系统,供学生开发各种应用软件。该系统以三星公司的ARM处理器S5PV210为控制核心,采用核心板加扩展板的设计方案,结合各种外围设备完成了相关的设计。目前,该平台上已成功运行了Android操作系统,并交由学生进行应用软件的开发。%In order to offer the students the practice platform, for students to develop application programs. The system takes the the application of main board and expansion board, and uses kinds cessfully running on the platform, and students begin to develop the this paper designs an ARM-based tablet PC hardware system Samsung's ARM processor S5PV210 as the core control, with of peripheral equipments. Currently, Android OS has been suc-application programs.

  9. 基才ARM和DS18820的温度监测系统%Temperature monitoring system based on ARM and DS18B20

    Institute of Scientific and Technical Information of China (English)

    王文; 王直

    2011-01-01

    Based on the ARM and DS18B20 temperature monitoring system use ARM as the data acquisition unit and digital temperature sensor DS18B20 as the temperature detection element. The overall system design, hardware design and software block diagram are given. The digital filtering of measured data is the average median filtering method.Meanwhile, the acquisition system connects the host computer via the serial port in order to achieve the network monitoring function.%基于ARM和DS18820的温度监测系统使用SAMSUNG公司的32位ARM微控制器S3C2440作为数据采集单元,数字温度传感器DS18820作为温度检测元件。给出了系统的总体设计方案、硬件设计及软件框图。对测得的数据采用防脉冲干扰平均滤波法进行数字滤波。同时,通过串行总线完成了采集系统与上位计算机的连接,实现了采集系统的网络化监测功能。

  10. 一种电动车用锂电池剩余容量检测系统%A SOC detecting system for electric bicycle battery

    Institute of Scientific and Technical Information of China (English)

    赵庆河

    2012-01-01

    针对电动车应用中的需求,提出了一种电动车用锂电池剩余容量(SOC)检测的方法,并设计了一套SOC检测系统.该系统以AVR单片机为控制及计算核心、以ACS712为电流采集器,采用线性光耦隔离模拟电压信号,集合充放电电流对时间的积分和BP神经网络估算两种方法来测量电池SOC值.该系统具有成本低、安全可靠、计算准确等特点,适合在电动车上推广使用.%For electric bicycle application demand, a method of electric bicycle lithium battery state of charge (SOC) detection is proposed, and a SOC detection system is designed. The system is based on AVR MCU as the control and calculation core, used ACS712 as current collector. It uses a linearopto -isolator to insulate analog voltage signal. It measures SOC of the battery integrating two methods which are current integration to the time and BP neural network estimation. The system has the advantages of low cost, safe and reliable, accurate calculation and other characteristics. It is suitable for use in electric vehicles.

  11. Crystal structure, characterization and magnetic properties of a 1D copper(II) polymer incorporating a Schiff base with carboxylate side arm

    Indian Academy of Sciences (India)

    SHYAMAPADA SHIT; MADHUSUDAN NANDY; CORRADO RIZZOLI; CÉDRIC DESPLANCHES; SAMIRAN MITRA

    2016-06-01

    A new 1D polymeric copper(II) complex [{Cu(L)$(CF_{3}COO)}2]_{n}$ has been synthesized using apotentially tetradentate Schiff base ligand, HL, ((E)-2-((pyridin-2-yl)methyleneamino)-5-chlorobenzoic acid)and characterized by different spectroscopic methods. Single crystal X-ray structural characterization revealsthat the side arm carboxylate group of the coordinated Schiff base exhibits a $μ_{1,3}$ -bridging mode and connectsthe neighbouring copper(II) ions leading to a zigzag 1D chain structure where the copper(II) ions displaydistorted square pyramidal geometries. Variable temperature magnetic susceptibility measurement reveals aweak antiferromagnetic exchange (J = −0.47±0.01 $cm_{−1}) prevails between copper(II) ions in the chainmediated by the bridging carboxylate group, is also supported by the room temperature EPR spectral study.Electrochemical property of the complex is also reported.

  12. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

    DEFF Research Database (Denmark)

    Adams, T E; Hansen, J A; Starr, R;

    1998-01-01

    Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were...... incubated with GH for various time points, and the expression of the SOCS gene family was analyzed by Northern blotting. GH stimulated the rapid, transient induction of SOCS-3 mRNA, peaking 30 min after the initiation of GH exposure and declining to basal levels by 2 h. Expression of the other SOCS genes...... (SOCS-1, SOCS-2, CIS) was also up-regulated by GH, although to a lesser extent than SOCS-3 and with differing kinetics. SOCS-3 expression was also strongly induced in 3T3-F442A cells treated with leukemia-inhibitory factor (LIF), with weaker induction of SOCS-1 and CIS being observed. The preferential...

  13. The Methylation of SOCS-1 Gene in Adult Acute Myeloid Leukemia%成人急性髓性白血病SOCS-1基因及其甲基化的研究

    Institute of Scientific and Technical Information of China (English)

    庄衍; 程毅敏; 汪雷; 窦红菊; 朱琦; 胡钧培

    2011-01-01

    Objective: To investigate the role of SOCS-1 (Suppressor of Cytokine Signalling-1) in tumorigenesis of adult acute myeloid leukemia (AMDby detecting the methylation state and expression of SOCS-1 gene. Methods: A total of 24 patients with AML, 10 healthy volunteers and 4 cell lines (Jurkat, Raji, U 937, NALM 17) were chosen. The methylation state of SOCS-1 in samples and cell lines were detected by using methylation-specific polymerase chain reation (MSP), and the expression of SOCS-1 was detected by using Real-time PCR. Results: The aberrant methylation of SOCS-1 was 62.5 % (15/24 )in primary patients with AML. In contrast, there was no aberrant methylation of SOCS-1 gene in normal samples (P<0.05). The expression of SOCS-1 in AML patients with aberrant methylation of SOCS-1 gene was lower than that in AML patients without aberrant methylation of SOCS-1 gene (P<0.05). There was no relation between the methylation of SOCS-1 gene and the clinicopathological data (such as sex, age and tumor stage). Conclusion: The methylation of SOCS-1 gene in AML was higher than that in control group significantly (P<0.05), and aberrant methylation strongly correlates with reduced expression. SOCS-1 gene may play an important role in tumorigenesis of AML.%目的:通过检测成人急性髓性白血病中SOCS-1基因表达水平及其甲基化水平,研究其在白血病发病中的作用.方法:运用甲基化特异性PCR(Methylation specific PCR,MSP)方法,对24例急性髓性白血病患者和4株白血病细胞株(Jurkat、Raji、U 937、NALM 17),进行SOCS-1基因甲基化水平的研究;同时运用Real-time PCR法定量分析SOCS-1基因表达水平.以10例健康人为正常对照组.结果:24例成人急性髓性白血病患者中,15例有SOCS-1基因甲基化(62.5%),而正常对照组无SOCS-1基因甲基化(0%),二者有显著差异( P<0.05);SOCS-1基因甲基化组与无SOCS-1基因甲基化组相比较,其SOCS-1基因相对表达量明显减少(P口0.05);与患

  14. Molecular characterization and immune response to lipopolysaccharide (LPS) of the suppressor of cytokine signaling (SOCS)-1, 2 and 3 genes in Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Liu, Cai-Zhi; He, An-Yuan; Chen, Li-Qiao; Limbu, Samwel Mchele; Wang, Ya-Wen; Zhang, Mei-Ling; Du, Zhen-Yu

    2016-03-01

    Suppressor of cytokine signaling (SOCS) proteins are inverse feedback regulators of cytokine and hormone signaling mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway that are involved in immunity, growth and development of organisms. In the present study, three SOCS genes, SOCS-1, SOCS-2 and SOCS-3, were identified in an economically important fish, Nile tilapia (Oreochromis niloticus) referred to as NtSOCS-1, NtSOCS-2 and NtSOCS-3. Multiple alignments showed that, the three SOCS molecules share highly conserved functional domains, including the SRC homology 2 (SH2) domain, the extended SH2 subdomain (ESS) and the SOCS box with others vertebrate counterparts. Phylogenetic analysis indicated that NtSOCS-1, 2 and 3 belong to the SOCS type II subfamily. Whereas NtSOCS-1 and 3 showed close evolutionary relationship with Perciformes, NtSOCS-2 was more related to Salmoniformes. Tissue specific expression results showed that, NtSOCS-1, 2 and 3 were constitutively expressed in all nine tissues examined. NtSOCS-1 and 3 were highly expressed in immune-related tissues, such as gills, foregut and head kidney. However, NtSOCS-2 was superlatively expressed in liver, brain and heart. In vivo, NtSOCS-1 and 3 mRNA levels were up-regulated after lipopolysaccharide (LPS) challenge while NtSOCS-2 was down-regulated. In vitro, LPS stimulation increased NtSOCS-3 mRNA expression, however it inhibited the transcription of NtSOCS-1 and 2. Collectively, our findings suggest that, the NtSOCS-1 and 3 might play significant role(s) in innate immune response, while NtSOCS-2 may be more involved in metabolic regulation. PMID:26820103

  15. 基于ARM7的新型开放式多功能医用信号仪的研制%Development of a Novel Open Multi-Function Instrument Based on ARM7 for Generating Medical Signal

    Institute of Scientific and Technical Information of China (English)

    陈龙聪; 刘改琴; 熊兴良; 高斌; 邓世雄

    2011-01-01

    目的 现有的常用信号发生器或生理信号发生器不能同时输出常用信号和模拟生理信号,本文提出一种新型开放式多功能医用信号仪,用于检测各种生理信号,听取不同频率、不同信号的声音及输出常用信号等.方法 该仪器以STM32F103RF和高性能集成芯片MAX038为核心.此医用信号仪包括硬件和软件两部分,其中硬件含有ARM7单片机控制单元、按钮组输入单元、数据存储单元等12个单元,软件用C语言编写,并采用keil C进行编译.结果 该仪器不仅能输出常用的正弦、方波、三角波、锯齿、矩形信号,还能输出医学中常用的多种生理信号如心电、脉搏波等,且信号波形频率、幅度、类型、波形均采用直观的LCD液晶显示.此外,该仪器具有一个高驱动能力的接口,可直接驱动耳机等,以方便对人耳频率特性和人体阻抗特性的研究和教学.同时,为了便于使用一般示波器能观察各种生理信号,对同一种生理信号可输出不同的频率.结论 本仪器使用方便,可广泛应用于科研、教学、测试和仪器维修等.%Objective To overcome shortages of available common multi-function physiological signal generators, which can not output the common and physiological signals simultaneously, a novel opening multifunction generator for physiological signal was introduced in this paper so that we can observe various physiological signals, hear the sound of different frequency or type signals, and obtain common signals. Methods Based on STM32F103RF microcomputer and the high performance signal chip MAX038, this instrument includes two parts, hardware and software. Its hardware, including microcontroller ARM7, keyboard, data memory and soon, was divided into twelve units. And complied by Keil C Vision3, the software was programmed by C language. Results This instrument output not only common types of signals, such as sine, square, triangle and sawtooth signals

  16. Design and Research of Intelligent Control System for Fruit and Vegetable Packaging Machine-Based on Embedded ARM%果蔬包装机智控系统的设计与研究-基于嵌入式 ARM

    Institute of Scientific and Technical Information of China (English)

    罗成; 刘志刚

    2016-01-01

    -tant.The AT91SAM9263 processor was used to design and research of the fruit and vegetable packing machine intelligent control system , the mechanical and electronic , intelligent test and a photoelectric sensor on various subjects based on ARM embedded .With a high degree of automation , high technology content , better accuracy and stability , high by fea-tures,it can greatly improve the quality of packaging , complete on different kinds of products packaging with strong adapt-ability .It not only improves the efficiency of packaging operations , but also savse the economic costand for farmers .

  17. Influence of overexpression of SOCS2 on cells of DN rat

    Institute of Scientific and Technical Information of China (English)

    Na-Na; Bao; De-Yang; Kong; Dan; Zhu; Li-Rong; Hao

    2015-01-01

    Objective: To explore the influence and mechanism of overexpression of SOCS2 on diabetic nephropathy(DN) rats and cells. Methods: STZ was used to induce male SD rats and SOCS2 was injected into left renal vein. Rats were divided into DN group, DN-Ad-null group and DNAd-SOCS2 group. Glucose with high and normal concentration was used to culture HBZY-1 cells and then transfect Ad-SOCS2. HG group, HG-Ad-null group, HG-Ad-SOCS2 group, CG group, CG-Ad-null group, and CG-Ad-SOCS2 group were created. The expression of inflammatory cytokines(MCP-1, TNF-α and IL-6) in kidney tissue of rats, fibrosis related protein(FN, Collagen Ⅳ and TGF-β) in kidney tissue and cells of rats, and JAK/STAT signaling pathway related proteins(p-JAK2 and p-STAT3) were tested by western blot. ELISA was used to test the expression of inflammatory cytokines(TNF-α and IL-6) in cells. Results: The expression of inflammatory cytokines in DN rats(MCP-1, TNF-α and IL-6) and cell(TNF-α and IL-6) were increased(P<0.01) significantly. However, SOCS2 could decrease the overexpression of mediated inflammatory cytokines in DN animal models and cell models(P<0.01). The expression of fibrosis related protein in DN rats and cells increased while SOCS2 decreased the overexpression of mediated fibrosis related protein in DN model rats and cells(P<0.01). The expression of JAK/STAT pathway related protein in both DN rats and cells increased and the JAK/STAT signaling pathway was activated. Yet, SOCS2 obviously suppressed the expression of the JAK/STAT signaling pathway as well as the related proteins(p-JAK2 and p-STAT3) in both DN rats and cells. Conclusions: The overexpression of SOCS2 can decrease the expression of inflammatory cytokines and fibrosis related proteins in DN rats and cells, and meanwhile suppress the activation of JAK/STAT signaling pathway mediated by DN.

  18. SoCRocket: A Virtual Platform for SoC Design

    Science.gov (United States)

    Fossati, Luca; Schuster, Thomas; Meyer, Rolf; Berekovic, Mladen

    2013-08-01

    how SoCRocket was used to optimize the design of a LEON3-based SoC targeted to the execution of an implementation of the CCSDS standard n.123 for the lossless compression of hyperspectral images.

  19. Expression of suppressor of cytokine signaling 1 (SOCS1 impairs viral clearance and exacerbates lung injury during influenza infection.

    Directory of Open Access Journals (Sweden)

    Keer Sun

    2014-12-01

    Full Text Available Suppressor of cytokine signaling (SOCS proteins are inducible feedback inhibitors of cytokine signaling. SOCS1-/- mice die within three weeks postnatally due to IFN-γ-induced hyperinflammation. Since it is well established that IFN-γ is dispensable for protection against influenza infection, we generated SOCS1-/-IFN-γ-/- mice to determine whether SOCS1 regulates antiviral immunity in vivo. Here we show that SOCS1-/-IFN-γ-/- mice exhibited significantly enhanced resistance to influenza infection, as evidenced by improved viral clearance, attenuated acute lung damage, and consequently increased survival rates compared to either IFN-γ-/- or WT animals. Enhanced viral clearance in SOCS1-/-IFN-γ-/- mice coincided with a rapid onset of adaptive immune responses during acute infection, while their reduced lung injury was associated with decreased inflammatory cell infiltration at the resolution phase of infection. We further determined the contribution of SOCS1-deficient T cells to antiviral immunity. Anti-CD4 antibody treatment of SOCS1-/-IFN-γ-/- mice had no significant effect on their enhanced resistance to influenza infection, while CD8+ splenocytes from SOCS1-/-IFN-γ-/- mice were sufficient to rescue RAG1-/- animals from an otherwise lethal infection. Surprisingly, despite their markedly reduced viral burdens, RAG1-/- mice reconstituted with SOCS1-/-IFN-γ-/- adaptive immune cells failed to ameliorate influenza-induced lung injury. In conclusion, in the absence of IFN-γ, the cytoplasmic protein SOCS1 not only inhibits adaptive antiviral immune responses but also exacerbates inflammatory lung damage. Importantly, these detrimental effects of SOCS1 are conveyed through discrete cell populations. Specifically, while SOCS1 expression in adaptive immune cells is sufficient to inhibit antiviral immunity, SOCS1 in innate/stromal cells is responsible for aggravated lung injury.

  20. 基于ARM温度检测系统设计%The Design of Temperature Measuring System Based on ARM

    Institute of Scientific and Technical Information of China (English)

    王双友

    2012-01-01

      本设计以ARM S3C2410为核心的温度检测系统。温度数据由温度芯片DS18B20采集,并以数字信号的方式传送给S3C2410处理芯片。详细论述了该系统的硬件组成和软件设计,实验证明本设计提高了系统的稳定性和可靠性。%  It gives a new type of Temperature Measuring System equipped with Samsung S3C2410. Chip DS18B20 is responsible for collecting temperature data, which was transmitted to the chip of S3C2410 in the way of digital signal. The hardware composition and software design of the system were discussed in detail. The experimental results indicate that the design improves the system stability and reliability.

  1. Locomotive Alarm Outfire Monitoring System Based on ARM%基于ARM的机车报警灭火监控系统

    Institute of Scientific and Technical Information of China (English)

    王祖麟; 赵志成

    2012-01-01

    This paper expounds the necessity ofconfigurating effective fire extinguishing device on the locomotive, and designs a alarm outfire monitoring system based on ARM. This system is detecting and monitoring in real time for running train, it makes the locomotive security system more perfect. It has a good practicability and expansibility.%本文阐述了在机车上配置有效灭火装置的必要性,设计了基于ARM的机车报警灭火监控系统。该系统对行进中的列车实时进行探测和监控,使机车的安保系统更加完善,具有良好的实用性和扩展性。

  2. Network-on-Chip: A New SoC Communication Infrastructure Paradigm

    Directory of Open Access Journals (Sweden)

    Naveen Choudhary

    2012-01-01

    Full Text Available As the feature size in deep-submicron domain is continuously shrinking and the bandwidth requirements is increasing, traditional shared-bus architecture will no longer be able to meet the requirements of System-on-Chip (SoC implementations. Specially, inherently non-scalable nature of the shared-bus architecture as well as its power hungry nature will become the communication bottleneck in most practical applications. Network-on-Chip (NoC communication architectures have emerged as a promising alternative to address the problems associated with on-chip buses by employing a packet-based micro-network for inter-IP communication. Some of the most important phases in designing the NoC are the design of the topology or structure of the network and setting of various design parameters (such as frequency of operation, link-width, etc. This paper surveys the various topological structures for NoC proposed in the research domain

  3. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.

    Science.gov (United States)

    Yeste, Ada; Takenaka, Maisa C; Mascanfroni, Ivan D; Nadeau, Meghan; Kenison, Jessica E; Patel, Bonny; Tukpah, Ann-Marcia; Babon, Jenny Aurielle B; DeNicola, Megan; Kent, Sally C; Pozo, David; Quintana, Francisco J

    2016-01-01

    Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated FoxP3(+) regulatory T (Treg) cells or tolerogenic dendritic cells (DCs) that promote Treg cell differentiation is considered a potential therapy for T1D; however, cell-based therapies cannot be easily translated into clinical practice. We engineered nanoparticles (NPs) to deliver both a tolerogenic molecule, the aryl hydrocarbon receptor (AhR) ligand 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), and the β cell antigen proinsulin (NPITE+Ins) to induce a tolerogenic phenotype in DCs and promote Treg cell generation in vivo. NPITE+Ins administration to 8-week-old nonobese diabetic mice suppressed autoimmune diabetes. NPITE+Ins induced a tolerogenic phenotype in DCs, which was characterized by a decreased ability to activate inflammatory effector T cells and was concomitant with the increased differentiation of FoxP3(+) Treg cells. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor κB activation and proinflammatory cytokine production (properties of tolerogenic DCs). Together, these data suggest that NPs constitute a potential tool to reestablish tolerance in T1D and potentially other autoimmune disorders. PMID:27330188

  4. Real-time Face Detection and Tracking Using Haar Classifier on SoC

    Directory of Open Access Journals (Sweden)

    Rajashree Tripathy

    2014-03-01

    Full Text Available In this paper we intend to Implement a real time Face detection and tracking the head poses position from high definition video using Haar Classifier through Raspberry Pi BCM2835 CPU processor which is a combination of SoC with GPU based Architecture. OV5647 CMOS Image sensor with 5-megapixel used for obtaining high definition video H.264 video data via GPU’s hardware video decoder to improve the playback of H.264 Video data supporting from 1080p at 30fps with complete user control over formatting and output data transfer also supporting with 720p/60HD video in full field of View(FOV. SimpleCV and OpenCV libraries are used for face detection and tracking the head poses position. The experimental result computed by using computer vision SimpleCV and OpenCV framework libraries along with above mentioned hardware results were obtained through of 30 fps under 1080p resolutions for higher accuracy and speediness for face detection and tracking the head poses position.

  5. Topical use of a silymarin-based preparation to prevent radiodermatitis. Results of a prospective study in breast cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Becker-Schiebe, Martina; Hoffmann, Wolfgang [Klinikum Braunschweig (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Mengs, Ulrich; Schaefer, Margitta [Rottapharm/Madaus, Koeln (Germany). Research and Development; Bulitta, Michael [CRM Biometrics GmbH, Rheinbach (Germany)

    2011-08-15

    More than 80% of patients with breast cancer undergoing postsurgical radiotherapy (RT) will develop radiodermatitis and approximately 10% of these patients show grade 3 lesions. Side effects may reduce the patient's compliance and can be limiting factors to follow RT protocols. Therefore, there is a high need for more effective prophylactic treatments. In this study, a silymarin-based cream (Leviaderm {sup registered}) was tested in comparison to our standard of care (SOC) at the involved site. A total of 101 patients were evaluated after breast-conserving surgery followed by RT with 50.4 Gy plus boost 9-16 Gy. Of these, 51 patients were treated with the silymarin-based cream. In addition, 50 patients were documented receiving a panthenol-containing cream interventionally, if local skin lesions occurred. The acute skin reactions were classified according to the RTOG and VAS (Visual Analogue Scale) scores. The median time to toxicity was prolonged significantly with silymarin-based cream (45 vs. 29 days (SOC), p < 0.0001). Only 9.8% of patients using silymarin-based cream showed grade 2 toxicity in week 5 of RT in comparison to 52% with SOC. At the end of RT, 23.5% of patients in the silymarin-based study group developed no skin reactions vs. 2% with SOC, while grade 3 toxicity occurred only in 2% in the silymarin-based arm compared to 28% (SOC). Silymarin-based cream Leviaderm {sup registered} may be a promising and effective treatment for the prevention of acute skin lesions caused by RT of breast cancer patients. To confirm the results of this nonrandomized, observational trial, this component should be tested in larger multicenter studies in this setting. (orig.)

  6. Key KdSOC1 gene expression profiles during plantlet morphogenesis under hormone, photoperiod, and drought treatments.

    Science.gov (United States)

    Liu, C; Zhu, C; Zeng, H M

    2016-01-01

    Kalanchoe daigremontiana utilizes plantlet formation between its zigzag leaf margins as its method of asexual reproduction. In this study, K. daigremontiana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (KdSOC1), a key intermediate in the transition from vegetative to asexual growth, was cloned. Furthermore, its expression profiles during plantlet formation under different environmental and hormone induction conditions were analyzed. The full-KdSOC1 cDNA sequence length was 1410 bp with 70% shared homology with Carya cathayensis SOC1. The conserved domain search of KdSOC1 showed the absence of I and C domains, which might indicate novel biological functions in K. daigremontiana. The full-KdSOC1 promoter sequence was 1401 bp long and contained multiple-hormone-responsive cis-acting elements. Hormone induction assays showed that gibberellins and salicylic acid mainly regulated KdSOC1 expression. The swift change from low to high KdSOC1 expression levels during long-day induction was accompanied by the rapid emergence of plantlets. Drought stress stimulated KdSOC1 expression in leaves both with and without plantlet formation. Together, the results suggested that KdSOC1 was closely involved in environmental stimulation signal perception and the transduction of K. daigremontiana plantlet formation. Therefore, future identification of KdSOC1 functions might reveal key information that will help elucidate the transition network between embryogenesis and organogenesis during plantlet formation. PMID:26909971

  7. Potential fate of SOC eroded from natural crusted soil surface under simulated wind driven storm

    Science.gov (United States)

    Xiao, Liangang; Fister, Wolfgang; Greenwood, Philip; Hu, Yaxian; Kuhn, Nikolaus J.

    2016-04-01

    Improving the assessment of the impact of soil erosion on carbon (C) cycling requires a better understanding of the redistribution of eroded sediment and associated soil organic carbon (SOC) across agricultural landscapes. Recent studies conducted on dry-sieved aggregates in the laboratory demonstrated that aggregation can profoundly skew SOC redistribution and its subsequent fate by accelerating settling velocities of aggregated sediment compared to mineral grains, which in turn can increase SOC mineralization into greenhouse gases. However, the erodibility of the soil in the field is more variable than in the laboratory due to tillage, crus formation, drying-wetting and freeze-thaw cycles, and biological effects. This study aimed to investigate the potential fate of the SOC eroded from naturally developed soil surface and to compare the observations with those made in the laboratory. Simulated, short, high intensity wind driven storms were conducted on a crusted loam in the field. The sediments were fractionated with a settling tube according to their potential transport distances. The soil mass, SOC concentration and cumulative 80-day CO2 emission of each fraction were identified. The results show: 1) 53% of eroded sediment and 62% of eroded SOC from the natural surface in the field would be deposited across landscapes, which is six times and three times higher compared to that implied by mineral grains, respectively; 2) the preferential deposition of SOC-rich fast-settling sediment potentially releases approximately 50% more CO2 than the same layer of the non-eroded soil; 3) the respiration of the slow-settling fraction that is potentially transported to the aquatic systems was much more active compared to the other fractions and the bulk soil. Our results confirm in general the conclusions drawn from laboratory and thus demonstrate that aggregation can affect the redistribution of sediment associated SOC under field conditions, including an increase in

  8. SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes.

    Science.gov (United States)

    Ha, You-Jung; Choi, Yong Seok; Kang, Eun Ha; Shin, Kichul; Kim, Tae Kyun; Song, Yeong Wook; Lee, Yun Jong

    2016-01-01

    CAAT/enhancer-binding protein-beta (C/EBPβ) is a transcription factor that regulates interleukin-1β (IL-1β)-induced catabolic pathways, including the expression of matrix metalloproteinases (MMPs), in chondrocytes. We previously reported that suppressor of cytokine signaling 1 (SOCS1) inhibits IL-1β signaling in chondrocytes. However, the effect of SOCS1 on C/EBPβ has not been explored. To investigate the interaction between SOCS1 and C/EBPβ, we established human SW1353 cells with overexpression or knockdown of SOCS1 or C/EBPβ. Both SOCS1 and C/EBPβ were involved in transcription of MMP-3 and MMP-13. When stimulated with IL-1β, C/EBPβ levels were significantly increased by SOCS1 knockdown and decreased by SOCS1 overexpression. A similar change in IL-1β-induced C/EBPβ expression was observed in SOCS1-transfected human articular chondrocytes. However, C/EBPβ overexpression or knockdown did not change the levels of IL-1β-induced SOCS1. SOCS1 regulated the levels of C/EBPβ mRNA by ubiquitination of C/EBPβ as well as transcriptional regulation. Furthermore, it suppressed the phosphorylation of cAMP response element-binding protein (CREB), an active transcription factor of C/EBPβ. In addition, p38 mitogen-activated protein kinases, a target of SOCS1, was involved in CREB phosphorylation. The chromatin immunoprecipitation assay confirmed that SOCS1 overexpression led to reduced binding of C/EBPβ to the MMP-13 promoter. Taken together, our results demonstrate that SOCS1 downregulates the p38-CREB-C/EBPβ pathway resulting in increased expression of MMPs in chondrocytes. PMID:27339399

  9. Effects of SOC-dependent electrolyte viscosity on performance of vanadium redox flow batteries

    International Nuclear Information System (INIS)

    Highlights: • The correlations of electrolyte viscosity and SOC are obtained. • Effect of SOC-dependent electrolyte viscosity is considered in this model. • This model enables a more realistic simulation of variable distributions. • It provides accurate estimations of pumping work and system efficiency. - Abstract: The viscosity of the electrolyte in vanadium redox flow batteries (VRFBs) varies during charge and discharge as the concentrations of acid and vanadium ions in the electrolyte continuously change with the state of charge (SOC). In previous VRFB models, however, the electrolyte has been treated as a constant-viscosity solution. In this work, a mass-transport and electrochemical model taking account of the effect of SOC-dependent electrolyte viscosity is developed. The comparison between the present model and the model with the constant-viscosity simplification indicates that the consideration of the SOC-dependent electrolyte viscosity enables (i) a more realistic simulation of the distributions of overpotential and current density in the electrodes, and (ii) more accurate estimations of pumping work and the system efficiency of VRFBs

  10. Design of Smart Merging Unit Based on FPGA and ARM%基于FPGA与ARM的智能合并单元设计

    Institute of Scientific and Technical Information of China (English)

    朱超; 黄灿; 梅军; 郑建勇

    2011-01-01

    To meet the requirements of smart substations for digital information. integrated functions and compact structure, the definitions of merging unit in IEC 6OO44 -8 and IEC 61850-9-1/2 are analyzed, and on this basis a smart merging unit based on field-programmable gate array (FPGA) and advanced RISC machines (ARM) is designed The auxiliary processor FPGA is responsible for synchronously receiving multi-channel data from different electronic transformers and implementing the parallel operation and switching-over of busbar by integrated Iogical control mechanism software; the main ARM prcessor is responsible for the real-time control of FPGA and sending the sampled data in the form specified in IEC 61850-9-2 by Ethemet, and the pre-configured sampled valne control block is utilized to implement the flexible definition of transmission model for sampled values to avoid the difficulty in implementing the mapping of manufacturing message specification (MMS) Testing results show that the proposed design is feasible and correct.%针对智能变电站信息数字化、功能集成化、结构紧凑化的要求,分析了IEC 60044-8、IEC 61850-9-1/2标准对合并单元的定义,在此基础上设计了一种基于现场可编程门阵列(field-programmable gate array,FPGA)与高级RISC微处理器(advanced RlSC machines,ARM)的智能合并单元.辅处理器FPGA负责多路数据的同步接收,并集成逻辑判别机制软件实现母线的并列运行和切换;主处理器ARM负责FPGA的实时控制并将采样值按IEC 61850-9-2标准通过以太网发送,采用预配置采样值控制块实现采样值传输模型的灵活定义,避免了制造报文规范(manufacturing message specification,MMS)映射的实现困难.试验结果表明了设计方法的可行性和正确性.

  11. Design of Automatic Sampling System Based on ARM%基于ARM的自动加样系统的设计

    Institute of Scientific and Technical Information of China (English)

    张冰洋; 武力; 徐文; 贾艳丽; 陈亚光

    2012-01-01

    为适应分析检测自动化样品前处理的需要,本文设计一种基于ARM和WinCE的三轴自动加样系统。该系统采用ARM9内核的S3C2440为硬件系统核心,以步进电机和蠕动泵为执行机构;在ARM上面移植了WinCE6.0操作系统,以此为基础开发应用软件;用LCD触摸屏来进行命令输入、工作状态监控等任务,进行人机交互。实现了操控界面友好、系统加样针管定位、吸排系统升降和流量控制等功能,具有定位准确,自动化程度高等特点,具有很强的实用价值。%Aiming at the demand of analytical automation of sampling pretreatment,an automatic sampling system based on ARM and WinCE is designed.S3C2440 was used as the core of hardware system,stepping motors and peristaltic pump were used as implementing agencies.The WinCE6.0 operation system was transplanted in ARM microprocessor as the application software development environment.LCD touch screen was used as human-computer interface,on which the operations of command inputting and work state monitoring were carried.A friendly control interface,the sampling syringes’ positioning,the imbibing-draining system’s ascending and flow controlling were designed.The system has the advantage of accurate position,micrometeor control and high automation.The technology and methods adopted in the system are practical and worthy of using abroad.

  12. Fabrication of dual responsive co-delivery system based on three-armed peptides for tumor therapy.

    Science.gov (United States)

    Chen, Si; Lei, Qi; Li, Shi-Ying; Qin, Si-Yong; Jia, Hui-Zhen; Cheng, Yin-Jia; Zhang, Xian-Zheng

    2016-06-01

    Introducing drugs into gene delivery systems to fabricate co-delivery systems for synergy therapy has become a promising strategy for tumor therapy. In this study, a dual responsive co-delivery system RHD/p53 was fabricated to enhance the antitumor efficacy with a low dose of doxorubicin (DOX). The reducible branched cationic polypeptide (RBCP), which was cross-linked via the thiol groups of two three-armed cationic peptides (CRR)2KRRC and (CHH)2KHHC, was designated as RH. Then, DOX was immobilized on RH via pH-sensitive hydrazone bonds to obtain RHD. The positively charged RHD could compress p53 plasmid to form RHD/p53 complexes. After RHD/p53 complexes accumulated in tumor sites, the ability of cell penetrating by cationic peptide (CRR)2KRRC would facilitate the cellular internalization of complexes. Then, the complexes would be trapped in endosome, and the cleavage of hydrazone bonds in the intracellular acidic endosome could lead to pH-induced release of DOX. Additionally, the ability of protonation by (CHH)2KHHC could promote the escape of complexes from endosome to cytoplasm. Due to the cleavage of disulfide bonds triggered by the high-content GSH in cytoplasm, the complexes would be degraded and released p53 for co-therapy to improve antitumor efficacy. Both in vitro and in vivo studies indicated that dual responsive co-delivery system RHD/p53 could enhance antitumor efficacy, which provides a useful strategy for co-delivery of different therapeutic agents in tumor treatment. PMID:27031930

  13. 基于ARM-Linux系统与组态王Modbus/TCP通讯的研究与实现%Research and Implementation of Modbus/TCP Communication Based on ARM-Linux System and KingView

    Institute of Scientific and Technical Information of China (English)

    陈文辉; 谭才彪; 许文明; 杨艳青

    2013-01-01

    Modbus/TCP工业以太网是运行在TCP/IP协议栈上的Modbus报文传输协议,组态王(KingView)是国内组态软件龙头.分析了Modbus/TCP的协议构成及其体系结构和组态王中的莫迪康Modbus/TCP协议,在嵌入式ARM9和Linux操作系统平台上实现了Modbus/TCP协议与组太王6.55的通讯.方案能有效实现工业现场的Arm-Linux系统与组态王的Modbus/TCP通信功能.

  14. Realistically Rendering SoC Traffic Patterns with Interrupt Awareness

    DEFF Research Database (Denmark)

    Angiolini, Frederico; Mahadevan, Sharkar; Madsen, Jan;

    2005-01-01

    generate realistic test traffic. This paper presents a selection of applications using interrupt-based synchronization; a reference methodology to split such applications in execution subflows and to adjust the overall execution stream based upon hardware events; a reactive simulation device capable of...

  15. Modbus Protocol Based Designs of ARM Farmland Server%基于Modbus协议ARM农田服务器的设计

    Institute of Scientific and Technical Information of China (English)

    袁福营; 史智兴; 靖立伟; 张宜君

    2014-01-01

    将Modbus协议应用到农业信息化领域,设计了一种基于Modbus协议的嵌入式农田信息采集服务器。分析了Modbus协议,设计了系统各模块之间的数据通信接口,ARM服务器与应用层采用Modbus/TCP通信完成用户的查询,ARM服务器与数据采集层采用Modbus串口通信进行数据的存储,提出了Modbus/TCP帧与串行链路RTU帧的转换方法,实现了应用层与数据采集层的实时通信,提高了系统的有效性和可靠性。%Modbus protocol was applied in the farmland information collection system and a preliminary design of an embed-ded farmland information collection server based on Modbus protocol was presented. ARM server using Modbus/TCP to com-municate with the application layer for completing the user’s query, and ARM server using seriallink to communicate with data acquisition layer for data storage were analyzed. The conversion of Modbus/TCP frame with serial link RTU frame was pro-posed to realize the communication for the application layer and the data acquisition layer. The design improved the effective-ness and reliability of the system.

  16. Study on the control system of automatic welding system based on ARM%基于ARM的机器人自动焊接控制系统

    Institute of Scientific and Technical Information of China (English)

    段锦程; 石永华; 俞国庆; 梁斌

    2011-01-01

    Welding distortion emerges in three-dimensional seam welding.The teaching-playback robot can not correct the deviation real-timely by itself.Therefore,it is necessary to correct the deviation during welding process real-timely.Based on ARM9-S3C2440,by using RS-232 to communicate with welding robot,this control system can adjust the welding traveling path in real-time.lt can control the position of the welding torch to get rid of the side effect of hot deformation.Using this control system, it is guaranteed that not only the welding torch moves along the seam center,but also that the contact tube to workpiece distance(CTWD) is equal.In welding experiments, it produces good welding quality.%立体曲线焊缝焊接时会产生较大的焊接变形,如以示教方式进行机器人焊接将导致焊接路径的偏离,必须在焊接过程中进行实时纠偏.设计开发了一种焊接机器人控制系统,硬件以ARM9-S3C2440为核心,通过RS232与机器人进行通信,编写了控制软件,实现了焊接机器人的焊枪位置实时调整,有效应对了焊接热变形的影响.既保证了焊枪沿着坡口中心运动,又保证了导电嘴到工件的距离(CTWD),焊接工艺稳定,焊缝质量较好.

  17. A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    International Nuclear Information System (INIS)

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm2. The design results show that it is very suitable for touch screen SoC applications. (semiconductor integrated circuits)

  18. Evidence for Coexistence of SOC, Intermittent Turbulence and Low-Dimensional Chaos Processes in Solar Flare Dynamics

    International Nuclear Information System (INIS)

    In this study, we present evidence for the co-existence of a SOC-like mechanism, of intermittent turbulence and a hidden low dimensional chaotic process underlying the solar activity. In particular, the original signal reveals a high dimensional stochastic character and a critical state according to a SOC process, since there in no clear discrimination between the original signal and its surrogate data concerning geometrical and dynamical characteristics of the solar time series. Furthermore, using the flat coefficient F we found evidence for intermittent turbulence behaviour. This result was based on the non-Gaussian character and the presence of long-range correlated plasma vorticity. This is in agreement with the low dimensional chaotic self-organization that was revealed after the application of a high pass filter to the original solar flares signal and provides further evidence for self organization in solar activity dynamics. Finally, the above results indicate the existence of a phase transition-like process in the solar corona dynamics, from high dimensional stochastic states to strong intermittent turbulence and low dimensional chaotic states, according to a general theory of critical dynamics applied to the driven and distributed solar corona system.

  19. Managing new arms races

    International Nuclear Information System (INIS)

    The management of new arms races in the region of Asia-Pacific includes considerations of weapons trade and transfer in the region, with an emphasis on nuclear weapons proliferation. It deals with the problem of controlling the arms trade and the efforts to control conventional weapons and underlines the possible role and influence of Conference on Cooperation and Security in Europe (CSCE)

  20. A four-armed Schiff base: 6,6′,6′′,6′′′-tetramethoxy-2,2′,2′′,2′′′-[methanetetrayltetrakis(methylenenitrilomethylidyne]tetraphenol

    Directory of Open Access Journals (Sweden)

    Guang-Qi Jiang

    2008-08-01

    Full Text Available In the structure of the title compound, C37H40N4O8, pentaerythrityltetramine is bonded to four o-vanillin molecules, forming a four-armed Schiff base molecule. These molecules are connected by intermolecular C—H...O hydrogen bonds. Intramolecular C—H...N and O—H...N hydrogen bonds are also present.

  1. Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development1

    OpenAIRE

    Scutti, Jorge A Borin; Matsuo, Alisson Leonardo; Pereira, Felipe Valença; Massaoka, Mariana Hiromi; Figueiredo, Carlos Rogério; Moreira, Dayson Friaça; Belizário, José Ernesto; Luiz R Travassos

    2011-01-01

    Melanoma is the most aggressive form of skin cancer, and its incidence has increased dramatically over the years. The murine B16F10 melanoma in syngeneic C57Bl/6 mice has been used as a highly aggressive model to investigate tumor development. Presently, we demonstrate in the B16F10-Nex2 subclone that silencing of SOCS-1, a negative regulator of Jak/Stat pathway, leads to reversal of the tumorigenic phenotype and inhibition of melanoma cell metastasis. SOCS-1 silencing with short hairpin RNA ...

  2. SOC storage in Swiss forest soils - driven by climate or historical land-use?

    Science.gov (United States)

    Gosheva, Sia; Walthert, Lorenz; Niklaus, Pascal; Zimmermann, Stephan; Hagedorn, Frank

    2015-04-01

    Soils store the most carbon of all terrestrial ecosystems, with forest soils being particularly carbon-rich (Schmidt et al. 2011; Hagedorn et al. 2010; Jobaggy & Jackson 2000). The C balance of soils might be altered by land-use changes such as in Switzerland, where the forest cover has increased by approximately 22% in the last century (Ginzler et al. 2011). The objectives of this study were 1) to determine whether historical forest cover change has an impact on soil organic carbon (SOC) storage in Swiss forests, and 2) to estimate the influence of climate on C-stocks in the organic layer and the mineral soil. In our study, we reconstructed forest cover changes for the last 150 years for the coordinates of 1000 soil profiles from the soil database of the Swiss Federal Institute for Forest, Snow and Landscape Research (WSL). We evaluated historical and modern topographic maps using ArcGIS, classifying current forest sites into permanently (≥150y) forested and newly forested sites (forest ages of the sites and of potentially additional drivers such as topography, climate, and soil properties on SOC stocks. Contrary to our expectations, our results indicate slightly higher SOC stocks in younger forest sites compared to permanently forested ones. This result could be observed in both organic layer (28,65 vs. 22,23 t C ha-1) and mineral soil (131,38 vs. 113,68 t C ha-1). We attribute the slightly smaller SOC stocks in the younger forests to their inherently higher SOC-stocks, as associated with favorable land previously used for grassland. Moreover, we observed higher SOC stocks under coniferous than under deciduous forest - however, this was only evident in the organic layer, but not in the mineral soil. Soil carbon increased significantly with decreasing mean annual temperature (MAT) and increasing precipitation (MAP), in particular in the organic layer. In addition to climate, we tested a number of other controlling factors such as altitude, pH, soil texture

  3. Regulation of pancreatic beta-cell mass and proliferation by SOCS-3

    DEFF Research Database (Denmark)

    Lindberg, K; Rønn, S G; Tornehave, D;

    2005-01-01

    Growth hormone and prolactin are important growth factors for pancreatic beta-cells. The effects exerted by these hormones on proliferation and on insulin synthesis and secretion in beta-cells are largely mediated through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT...... tyrosine phosphorylation of STAT-5 when compared with wild-type islets. Transduction of primary islet cultures with adenoviruses expressing various SOCS proteins followed by stimulation with GH or glucagon-like peptide-1 (GLP-1) revealed that SOCS-3 inhibited GH- but not GLP-1-mediated islet cell...

  4. Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

    Directory of Open Access Journals (Sweden)

    Marc Amoyel

    2016-01-01

    Full Text Available The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs, which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs, which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mutant clones, they lose their competitiveness but maintain self-renewal, presumably due to increased JAK/STAT signaling in these cells. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. Thus, our results enable the genetic separation of two essential processes that occur in stem cells. While some niche signals specify the intrinsic property of self-renewal, which is absolutely required in all stem cells for niche residence, additional signals control the ability of stem cells to compete with their neighbors. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.

  5. A Reconfigurable Network-on-Chip Architecture for Optimal Multi-Processor SoC Communication

    OpenAIRE

    Rana, Vincenzo; Atienza, David; Santambrogio, Marco Domenico; Sciuto, Donatella; De Micheli, Giovanni

    2010-01-01

    Network-on-Chip (NoC) has emerged as a very promising paradigm for designing scalable communication architecture for Systems on Chips (SoCs). However, NoCs designed to fulfill the bandwidth requirements between the cores of an SoC for a certain set of running applications may be highly sub-optimal for another set of applications. In this context, methods that can lead to versatility enhancements of initial NoC designs to changing working conditions, imposed by variable sets of executed real-l...

  6. DMPD: Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17070092 Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functio...Epub 2006 Oct 27. (.png) (.svg) (.html) (.csml) Show Suppressor of cytokine signaling (SOCS) 2, a protein with multi...SOCS) 2, a protein with multiple functions. Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L. Pu...ple functions. PubmedID 17070092 Title Suppressor of cytokine signaling (

  7. SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma.

    Science.gov (United States)

    Iwahori, Kota; Serada, Satoshi; Fujimoto, Minoru; Ripley, Barry; Nomura, Shintaro; Mizuguchi, Hiroyuki; Shimada, Kazuki; Takahashi, Tsuyoshi; Kawase, Ichiro; Kishimoto, Tadamitsu; Naka, Tetsuji

    2013-01-15

    Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis for which an effective therapy remains to be established. This study investigated the therapeutic potential of gene delivery using suppressor of cytokine signaling 1 (SOCS-1), an endogenous inhibitor of intracellular signaling pathways, for the treatment of MPM. We infected MPM cells (MESO-4, H28 and H226) with adenovirus-expressing SOCS-1 vector to examine the effect of SOCS-1 overexpression on MPM cells. We evaluated the antitumor effect of SOCS-1 gene delivery combined with cisplatin plus pemetrexed by cell proliferation, apoptosis and invasion assay. We also investigated the regulation of NF-κB and STAT3 signaling related to apoptotic pathways. Furthermore, we evaluated the inhibition of tumor growth by SOCS-1 gene delivery combined with cisplatin plus pemetrexed in vivo. SOCS-1 gene delivery cooperated with cisplatin plus pemetrexed to inhibit cell proliferation, invasiveness and induction of apoptosis in MPM cells. SOCS-1 regulated NF-κB and STAT3 signaling to induce apoptosis in MESO-4 and H226 cells. Furthermore, SOCS-1 gene delivery cooperated with cisplatin plus pemetrexed to regulate NF-κB signaling and significantly inhibit tumor growth of MPM in vivo. These results suggest that SOCS-1 gene delivery has a potent antitumor effect against MPM and a potential for clinical use in combination with cisplatin plus pemetrexed. PMID:22532243

  8. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

    DEFF Research Database (Denmark)

    Greenhalgh, Christopher J; Metcalf, Donald; Thaus, Anne L;

    2002-01-01

    attenuate growth hormone (GH) signaling. In vitro studies indicate that, while SOCS-2 can inhibit GH action at low concentrations, at higher concentrations it may potentiate signaling. To determine whether a similar enhancement of signaling is observed in vivo or alternatively whether increased SOCS-2...... number of mouse organs, while phosphopeptide binding studies with recombinant SOCS-2 defined phosphorylated tyrosine 595 on the GH receptor as the site of interaction. Together, the data implicate SOCS-2 as having dual effects on GH signaling in vivo....

  9. ZmSOC1, a MADS-Box Transcription Factor from Zea mays, Promotes Flowering in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Suzhou Zhao

    2014-11-01

    Full Text Available Zea mays is an economically important crop, but its molecular mechanism of flowering remains largely uncharacterized. The gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1, integrates multiple flowering signals to regulate floral transition in Arabidopsis. In this study, ZmSOC1 was isolated from Zea mays. Sequence alignment and phylogenetic analysis demonstrated that the ZmSOC1 protein contained a highly conserved MADS domain and a typical SOC1 motif. ZmSOC1 protein was localized in the nucleus in protoplasts and showed no transcriptional activation activity in yeast cells. ZmSOC1 was highly expressed in maize reproductive organs, including filaments, ear and endosperm, but expression was very low in embryos; on the other hand, the abiotic stresses could repress ZmSOC1 expression. Overexpression of ZmSOC1 resulted in early flowering in Arabidopsis through increasing the expression of AtLFY and AtAP1. Overall, these results suggest that ZmSOC1 is a flowering promoter in Arabidopsis.

  10. Longevity of contributions to SOC stocks from roots and aboveground plant litter below a Miscanthus plantation

    Science.gov (United States)

    Robertson, Andrew; Smith, Pete; Davies, Christian; Bottoms, Emily; McNamara, Niall

    2013-04-01

    Miscanthus is a lignocellulosic crop that uses the Hatch-Slack (C4) photosynthetic pathway as opposed to most C3 vegetation native to the UK. Miscanthus can be grown for a number of practical end-uses but recently interest has increased in its viability as a bioenergy crop; both providing a renewable source of energy and helping to limit climate change by improving the carbon (C) budgets associated with energy generation. Recent studies have shown that Miscanthus plantations may increase stocks of soil organic carbon (SOC), however the longevity and origin of this 'new' SOC must be assessed. Consequently, we combined an input manipulation experiment with physio-chemical soil fractionation to quantify new SOC and CO2 emissions from Miscanthus roots, decomposing plant litter and soil individually. Further, fractionation of SOC from the top 30 cm gave insight into the longevity of that SOC. In January 2009 twenty-five 2 m2 plots were set up in a three-year old 11 hectare Miscanthus plantation in Lincolnshire, UK; with five replicates of five treatments. These treatments varied plant input to the soil by way of controlled exclusion techniques. Treatments excluded roots only ("No Roots"), surface litter only ("No Litter"), both roots and surface litter ("No Roots or Litter") or had double the litter amount added to the soil surface ("Double Litter"). A fifth treatment was a control with undisturbed roots and an average amount of litter added. Monthly measurements of CO2 emissions were taken at the soil surface from each treatment between March 2009 and March 2013, and soil C from the top 30 cm was monitored in all plots over the same period. Miscanthus-derived SOC was determined using the isotopic discrimination between C4 plant matter and C3 soil, and soil fractionation was then used to establish the longevity of that Miscanthus-derived SOC. Ongoing results for CO2 emissions indicate a strong seasonal variation; litter decomposition forms a large portion of the CO2

  11. Accounting for complex entities: implications for ARMS

    OpenAIRE

    Moss, Charles B.; Klinefelter, Danny A.

    2012-01-01

    Purpose – The purpose of this research is to examine the effect of accounting for complex organizational forms on data collection with the Agricultural Resource Management Survey (ARMS). Design/methodology/approach – This research reviews the literature from accounting theory along with the goals of data collection for policy analysis to draw conclusions about the applicability of accounting pronouncements. Findings – Historically, the financial data collected in ARMS were based on financial ...

  12. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  13. Nonspecific Arm Pain

    Directory of Open Access Journals (Sweden)

    Ali Moradi

    2013-12-01

    Full Text Available   Nonspecific activity-related arm pain is characterized by an absence of objective physical findings and symptoms that do not correspond with objective pathophysiology. Arm pain without strict diagnosis is often related to activity, work-related activity in particular, and is often seen in patients with physically demanding work. Psychological factors such as catastrophic thinking, symptoms of depression, and heightened illness concern determine a substantial percentage of the disability associated with puzzling hand and arm pains. Ergonomic modifications can help to control symptoms, but optimal health may require collaborative management incorporating psychosocial and psychological elements of illness.

  14. A Global Obstacle-avoidance Map for Anthropomorphic Arms

    Directory of Open Access Journals (Sweden)

    Cheng Fang

    2014-07-01

    Full Text Available More and more humanoid robots are used in human society, and they face a wide variety of complicated manipulation tasks, which are mainly to be achieved by their anthropomorphic arms. Obstacle avoidance for the anthropomorphic arm must be a fundamental consideration to guarantee the successful implementation of these tasks. Different from traditional methods searching for feasible or optimal collision-free solutions for the anthropomorphic arm, a global obstacle- avoidance map for the whole arm is proposed to indicate the complete set of feasible solutions. In this map, the motion of the arm can be appropriately planned to intuitively control the configuration of the arm in motion. First, the cubic spline function is adopted to interpolate some well-chosen path points to generate a smooth collision-free path for the wrist of the anthropomorphic arm. Second, based on the path function of the wrist, the time and the self-rotation angle of the arm about the “shoulder-wrist” axis are used to parameterize all possible configurations of the arm so that a global two- dimensional map considering the obstacle avoidance can be established. Subsequently, a collision-free self-rotation angle profile of the arm can be well planned. Finally, the joint trajectories of a specific anthropomorphic arm, which correspond to the planned path of the wrist and self-rotation angle profile of the arm, can be solved on the basis of the general kinematic analysis of the anthropomorphic arm, and the specific structure. Several simulations are conducted to verify that the proposed collision-free motion planning method for anthropomorphic arms has some advantages and can be regarded as a convenient and intuitive tool to control the configuration of the anthropomorphic arm in motion, without collision with obstacles in its surroundings.

  15. Design of a novel 3-DOF hybrid mechanical arm

    Institute of Scientific and Technical Information of China (English)

    LI YanBiao; JIN ZhenLin; JI ShiMing

    2009-01-01

    Parameter optimization for a novel 3-DOF hybrid mechanical arm was presented by using a statistics method called the statistics parameters optimization method based on index atlases.Several kinematics and mechanics performance evaluation indices were proposed and discussed,according to the kinematics and mechanics analyses of the mechanical arm.Considering the assembly technique,a prototype of the 3-DOF hybrid mechanical arm was developed,which provided a basis for applications of the 3-DOF hybrid mechanical arm.The novel 3-DOF hybrid mechanical arm can be applied to the modern industrial fields requiring high stiffness,lower inertia and good technological efficiency.A novel 6-DOF hybrid humanoid mechanical arm was built,in which the present mechanical arm was connected with a spherical 3-DOF parallel manipulator.

  16. 基于ARM的智能家居控制系统设计%Design of smart home control system based on ARM

    Institute of Scientific and Technical Information of China (English)

    杨晓迪; 廖昕; 古丽米拉·克孜尔别克; 孙中华

    2015-01-01

    针对传统智能家居采用有线组建布线繁琐,增减设备需要重新布线,影响美观,且系统中的家电需要依靠家庭内部的PC,升级和维护均不方便。在此将ZigBee无线通信技术及嵌入式ARM技术结合在一起,利用Qt技术通过触摸屏进行人机交互,设计了一种既能利用PC机又能利用手持终端对家居进行控制的智能家居控制系统。以现有嵌入式ARM微处理器的开发和控制水平,开展基于ZigBee的网点部署的研究,以无线网实施家居电器的控制和管理。测试表明,该系统具有良好的实用性、可靠性和可扩展性。%Since the cumbersome wired formation is used in traditional smart home,rewiring is needed when equipment changes,its appearance is affected,the appliances in the system rely on the PC in the house,and upgrades and maintenance are not convenient. Therefore,a smart home control system controlled by PC or hand⁃held terminal was designed by combining the ZigBee wireless communication technology with the embedded ARM technology and Qt technology for human⁃computer in⁃teraction via the touch screen. Based on developing level and control ability of existing embedded ARM microprocessor,the re⁃search on network deployment based on ZigBee was carried out. The control and management of household electrical appliances are implemented through wireless network. Test results show that the system has good practicability,reliability and scalability.

  17. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

    DEFF Research Database (Denmark)

    Iglesias Gato, Diego; Chuan, Yin Choy; Wikström, Pernilla;

    2014-01-01

    Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2) a...

  18. Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    DEFF Research Database (Denmark)

    Gylvin, T; Ek, J; Nolsøe, R.;

    2009-01-01

    AIMS/HYPOTHESIS: The suppressor of cytokine signalling 1 (SOCS1) is a natural inhibitor of cytokine and insulin signalling pathways and may also play a role in obesity. In addition, SOCS1 is considered a candidate gene in the pathogenesis of both type 1 diabetes (T1D) and type 2 diabetes (T2D). The...... objective was to perform mutation analysis of SOCS1 and to test the identified variations for association to T2D-related quantitative traits, T2D or T1D. METHODS: Mutation scanning was performed by direct sequencing in 27 white Danish subjects. Genotyping was carried out by TaqMan allelic discrimination. A...... both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. The rs33977706 affected both binding of a nuclear protein to and the transcriptional activity of the SOCS1 promoter, indicating a relationship between this polymorphism and gene...

  19. Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2 Polymorphism in Different Dog Breeds

    Directory of Open Access Journals (Sweden)

    Martina Miluchová

    2011-05-01

    Full Text Available SOCS2 is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. The aim of the paper was to identify of suppressor of cytokine signaling 2 gene (SOCS2 polymorphism in different dog breeds. The material involved 77 dogs from 14 different breeds. Canine genomic DNA was isolated from saliva by modified method with using DNAzol® (Molecular Research Center and linear polyacrylamide (LPA carrier and from blood by using NucleospinBlood (Macherey-Nagel and used in order to estimate SOCS2 genotypes by PCR-RFLP method. The PCR products were digested with TaqI restriction enzyme. The T allele was distributed among large dog breeds (Czech pointer, Golden retriever, Rottweiler with an allele frequency ranging from 0.2857 to 1.00. In the population of Czech pointer we detected all genotypes. There were detected homozygote genotype GG with frequency 0.5476, heterozygote genotype GT with frequency 0.3333 and homozygote genotype TT with frequency 0.1191. Results point out that frequency of G allele was high and was represented 0.7143. Frequency of T allele was 0.2857. In Rottweiler was detected homozygote genotype TT. Genotypes GG and GT has not been observed. In Golden retriever we detected only heterozygote genotype GT.

  20. 基于ARM&Linux的手持式室内甲醛气体检测设备设计%Design of Hand-hold Indoor Formaldehyde Detector Based on ARM&Linux

    Institute of Scientific and Technical Information of China (English)

    万松峰

    2013-01-01

    采用电化学检测方法,以ARM&Linux嵌入式平台为核心,选用Membrapor公司的CH2O/M-10传感器设计了一种室内甲醛气体手持检测设备.详细介绍了该设备的硬件架构和软件设计,并与传统甲醛检测仪做了对比实验.实验结果表明,2种设备测定样品所得到的结果无显著性差异;手持检测设备检测快捷方便,可用于室内环境甲醛的检测.%The paper introduces the design of a new-style indoor formaldehyde detector. This detector is designed with the adoption of the ARM&Linux embedded platform together with CH20/M-10 electrochemical formaldehyde-sensor made in Membrapor. The hardware architecture and the software design process of formaldehyde detector are described. A test is carried out using the formaldehyde detector designed. Comparison is made between the formaldehyde detector designed and traditional formaldehyde detectors. Results show that the results obtained by the two measuring methods have no significant difference, and the detection by using formaldehyde detector is easy and quick,it can be used for the test of formaldehyde in indoor environment。

  1. A Yaw Moment Counteracting Method for Humanoid Robot Based on Arms Swinging%基于双臂摆动的仿人机器人偏摆力矩矫正方法

    Institute of Scientific and Technical Information of China (English)

    付根平; 陈建平; 杨宜民

    2012-01-01

    针对仿人机器人在步行时产生的绕ZMP(零力矩点)的偏摆力矩导致其失稳甚至摔倒的问题,提出了一种基于双臂摆动的偏摆力矩矫正方法.分析了偏摆力矩产生的原因及其对机器人步行稳定性的影响;根据仿人机器人的连杆模型和手臂摆动的单摆模型,推导出了双臂摆动力矩的表达式,结合双臀摆动的示意图阐述了利用双臂摆动力矩矫正偏摆力矩的原理;采用三次样条插值规划出双臂参数化的摆动角轨迹.再通过穷举法遍历摆动角参数使双臂摆动力矩满足偏摆力矩的矫正要求.仿真结果表明,该方法不仪能较好地矫正偏摆力矩,使机器人实现稳定的步行,而且能保证双臂的摆动角轨迹单调、平滑和 周期性.%In view of the problems of unstable walking and even falling down caused by the yaw moment around zero moment point (ZMP) when the humanoid robot walks, a method for counteracting the yaw moment based on arms swinging is proposed. The cause of the yaw moment and its effect on the robot walking stability are analyzed. According to the link model of humanoid robot and the single pendulum model of arm swinging, the expression of moment generated by arms swinging is deduced, and the principle of counteracting yaw moment with the arms swinging moment is formulated by using the illustration of arms swinging. With the adoption of cubic spline interpolation, the parametric angle trajectories of arms swinging are planned. Through the exhaustive search algorithm, the angle parameters are traversed to guarantee the yaw moment to be mostly counteracted by the arms swinging moment. The simulation result verifies that the method can not only counteract the yaw moment greatly to ensure walking stability of the humanoid robot, but also guarantee the monotonicity, the smoothness and the periodicity of the angle trajectories of arms swinging.

  2. An improved instrument mounting arm.

    Science.gov (United States)

    Gendeh, B S; Khalid, B A; Alberti, P W

    2001-02-01

    Although some form of commercial instrument mounting arm is available, a paucity of information in the literature may cause problems in selecting the most appropriate model for an ENT department wishing to trial their invention for use in the clinic or operating theatre. The instrument mounting arm described here is based on existing designs used by hobbyists and model makers for many years but the main benefit of this innovation is its multi-purpose use in the operating theatre and cost effectiveness since it is made of aluminum alloy. It is compact, stable and easily adjustable and can incorporate an endoscope holder or an operating end piece to mount various ENT instruments that offers considerable advantages to the unassisted operator. PMID:11320829

  3. Dual redundant arm system operational quality measures and their applications - Dynamic measures

    Science.gov (United States)

    Lee, Sukhan; Kim, Sungbok

    1990-01-01

    Dual-arm dynamic operation quality measures are presented which quantify the efficiency and capability of generating Cartesian accelerations by two cooperative arms based on the analysis of dual-arm dynamic interactions. Dual-arm dynamic manipulability is defined as the efficiency of generating Cartesian accelerations under the dynamic and kinematic interactions between individual arms and an object under manipulation. The analysis of dual-arm dynamic interactions is based on the so-called Cartesian space agent model of an arm, which represents an individual arm as a force source acting upon a point mass with the effective Cartesian space arm dynamics and an environment or an object under manipulation. The Cartesian space agent model of an arm makes it possible to derive the dynamic and kinematic constraints involved in the transport, assembly and grasping modes of dual-arm cooperation. A task-oriented operational quality measure, (TOQd) is defined by evaluating dual-arm dynamic manipulability in terms of given task requirements. TOQd is used in dual-arm joint configuration optimization. Simulation results are shown. A complete set of forward dynamic equations for a dual-arm system is derived, and dual-arm dynamic operational quality measures for various modes of dual-arm cooperation allowing sliding contacts are established.

  4. An Elastica Arm Scale

    CERN Document Server

    Bosi, F; Corso, F Dal; Bigoni, D

    2015-01-01

    The concept of 'deformable arm scale' (completely different from a traditional rigid arm balance) is theoretically introduced and experimentally validated. The idea is not intuitive, but is the result of nonlinear equilibrium kinematics of rods inducing configurational forces, so that deflection of the arms becomes necessary for the equilibrium, which would be impossible for a rigid system. In particular, the rigid arms of usual scales are replaced by a flexible elastic lamina, free of sliding in a frictionless and inclined sliding sleeve, which can reach a unique equilibrium configuration when two vertical dead loads are applied. Prototypes realized to demonstrate the feasibility of the system show a high accuracy in the measure of load within a certain range of use. It is finally shown that the presented results are strongly related to snaking of confined beams, with implications on locomotion of serpents, plumbing, and smart oil drilling.

  5. ARM7-kehityskortti

    OpenAIRE

    Kukkonen, Henri

    2006-01-01

    Tämän opinnäytetyön tarkoituksena oli suunnitella ja toteuttaa ARM-mikro-ohjain pohjainen kehityskortti. Kortin tuli olla soveltuva ARM-ohjelmoinnin opettamiseen. Työssä myös selvitettiin ARM-mikro-ohjaimen ohjelmointiympäristön käyttöönotto. Teoriaosassa käsitellään ARM-arkkitehtuuria, työssä käytettyjen Atmelin AT91R40008-mikro-ohjaimen sekä Philipsin LPC2105-mikro-ohjaimen ominaisuuksia. Erityisesti työssä keskitytään kehityskorttien suunnitteluun. Kehityskortin vaatimuksina oli, että se ...

  6. Suppression of microRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway.

    Science.gov (United States)

    Tan, Yi; Yang, Jun; Xiang, Kai; Tan, Qindong; Guo, Qulian

    2015-03-01

    Chronic neuropathic pain is an unfavourable pathological pain characterised by allodynia and hyperalgesia which has brought considerable trouble to people's physical and mental health, but effective therapeutics are still lacking. MicroRNAs (miRNAs) have been widely studied in the development of neuropathic pain and neuronal inflammation. Among various miRNAs, miR-155 has been widely studied. It is intensively involved in regulating inflammation-associated diseases. However, the role of miR-155 in regulating neuropathic pain development is poorly understood. In the present study, we aimed to investigate whether miR-155 is associated with neuropathic pain and delineate the underlying mechanism. Using a neuropathic pain model of chronic constriction injury (CCI), miR-155 expression levels were markedly increased in the spinal cord. Inhibition of miR-155 significantly attenuated mechanical allodynia, thermal hyperalgesia and proinflammatory cytokine expression. We also demonstrated that miR-155 directly bound with the 3'-untranslated region of the suppressor of cytokine signalling 1 (SOCS1). The expression of SOCS1 significantly decreased in the CCI rat model, but this effect could be reversed by miR-155 inhibition. Furthermore, knockdown of SOCS1 abrogated the inhibitory effects of miR-155 inhibition on neuropathic development and neuronal inflammation. Finally, we demonstrated that inhibition of miR-155 resulted in the suppression of nuclear factor-κB and p38 mitogen-activated protein kinase activation by mediating SOCS1. Our data demonstrate the critical role of miR-155 in regulating neuropathic pain through SOCS1, and suggest that miR-155 may be an important and potential target in preventing neuropathic pain development. PMID:25488154

  7. t(8;9(p22;p24/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.

    Directory of Open Access Journals (Sweden)

    Stefan Ehrentraut

    Full Text Available Fusions of the tyrosine kinase domain of JAK2 with multiple partners occur in leukemia/lymphoma where they reportedly promote JAK2-oligomerization and autonomous signalling, Affected entities are promising candidates for therapy with JAK2 signalling inhibitors. While JAK2-translocations occur in myeloid, B-cell and T-cell lymphoid neoplasms, our findings suggest their incidence among the last group is low. Here we describe the genomic, transcriptional and signalling characteristics of PCM1-JAK2 formed by t(8;9(p22;p24 in a trio of cell lines established at indolent (MAC-1 and aggressive (MAC-2A/2B phases of a cutaneous T-cell lymphoma (CTCL. To investigate signalling, PCM1-JAK2 was subjected to lentiviral knockdown which inhibited 7 top upregulated genes in t(8;9 cells, notably SOCS2/3. SOCS3, but not SOCS2, was also upregulated in a chronic eosinophilic leukemia bearing PCM1-JAK2, highlighting its role as a central signalling target of JAK2 translocation neoplasia. Conversely, expression of GATA3, a key T-cell developmental gene silenced in aggressive lymphoma cells, was partially restored by PCM1-JAK2 knockdown. Treatment with a selective JAK2 inhibitor (TG101348 to which MAC-1/2A/2B cells were conspicuously sensitive confirmed knockdown results and highlighted JAK2 as the active moiety. PCM1-JAK2 signalling required pSTAT5, supporting a general paradigm of STAT5 activation by JAK2 alterations in lymphoid malignancies. MAC-1/2A/2B--the first JAK2-translocation leukemia/lymphoma cell lines described--display conspicuous JAK/STAT signalling accompanied by T-cell developmental and autoimmune disease gene expression signatures, confirming their fitness as CTCL disease models. Our data support further investigation of SOCS2/3 as signalling effectors, prognostic indicators and potential therapeutic targets in cancers with JAK2 rearrangements.

  8. Hello to Arms

    Science.gov (United States)

    2005-01-01

    This image highlights the hidden spiral arms (blue) that were discovered around the nearby galaxy NGC 4625 by the ultraviolet eyes of NASA's Galaxy Evolution Explorer. The image is composed of ultraviolet and visible-light data, from the Galaxy Evolution Explorer and the California Institute of Technology's Digitized Sky Survey, respectively. Near-ultraviolet light is colored green; far-ultraviolet light is colored blue; and optical light is colored red. As the image demonstrates, the lengthy spiral arms are nearly invisible when viewed in optical light while bright in ultraviolet. This is because they are bustling with hot, newborn stars that radiate primarily ultraviolet light. The youthful arms are also very long, stretching out to a distance four times the size of the galaxy's core. They are part of the largest ultraviolet galactic disk discovered so far. Located 31 million light-years away in the constellation Canes Venatici, NGC 4625 is the closest galaxy ever seen with such a young halo of arms. It is slightly smaller than our Milky Way, both in size and mass. However, the fact that this galaxy's disk is forming stars very actively suggests that it might evolve into a more massive and mature galaxy resembling our own. The armless companion galaxy seen below NGC 4625 is called NGC 4618. Astronomers do not know why it lacks arms but speculate that it may have triggered the development of arms in NGC 4625.

  9. Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3

    DEFF Research Database (Denmark)

    Kazi, Julhash U; Sun, Jianmin; Phung, Bengt;

    2012-01-01

    The receptor tyrosine kinase Flt3 is an important growth factor receptor in hematopoiesis, and gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia. SOCS6 (suppressor of cytokine signaling 6) is a member of the SOCS family of E3 ubiquitin ligases...... that can regulate receptor tyrosine kinase signal transduction. In this study, we analyzed the role of SOCS6 in Flt3 signal transduction. The results show that ligand stimulation of Flt3 can induce association of SOCS6 and Flt3 and tyrosine phosphorylation of SOCS6. Phosphopeptide fishing indicated...... that SOCS6 binds directly to phosphotyrosines 591 and 919 of Flt3. By using stably transfected Ba/F3 cells with Flt3 and/or SOCS6, we show that the presence of SOCS6 can enhance ubiquitination of Flt3, as well as internalization and degradation of the receptor. The presence of SOCS6 also induces weaker...

  10. The shortened disabilities of the arm, shoulder and hand questionnaire (QuickDASH: validity and reliability based on responses within the full-length DASH

    Directory of Open Access Journals (Sweden)

    Ward Michael M

    2006-05-01

    Full Text Available Abstract Background The 30-item disabilities of the arm, shoulder and hand (DASH questionnaire is increasingly used in clinical research involving upper extremity musculoskeletal disorders. From the original DASH a shorter version, the 11-item QuickDASH, has been developed. Little is known about the discriminant ability of score changes for the QuickDASH compared to the DASH. The aim of this study was to assess the performance of the QuickDASH and its cross-sectional and longitudinal validity and reliability. Methods The study was based on extracting QuickDASH item responses from the responses to the full-length DASH questionnaire completed by 105 patients with a variety of upper extremity disorders before surgery and at follow-up 6 to 21 months after surgery. The DASH and QuickDASH scores were compared for the whole population and for different diagnostic groups. For longitudinal construct validity the effect size and standardized response mean were calculated. Analyses with ROC curves were performed to compare the ability of the DASH and QuickDASH to discriminate among patients classified according to the magnitude of self-rated improvement. Cross-sectional and test-retest reliability was assessed. Results The mean DASH score was 34 (SD 22 and the mean QuickDASH score was 39 (SD 24 at baseline. For the different diagnostic groups the mean and median QuickDASH scores were higher than the corresponding DASH scores. For the whole population, the mean difference between the QuickDASH and DASH baseline scores was 4.2 (95% CI 3.2–5.3, follow-up scores was 2.6 (1.7–3.4, and change scores was 1.7 (0.6–2.8. The overall effect size and standardized response mean measured with the DASH and the QuickDASH were similar. In the ROC analysis of change scores among patients who rated their arm status as somewhat or much better and those who rated it as unchanged the difference in the area under the ROC curve for the DASH and QuickDASH was 0.01 (95% CI -0

  11. 基于ARM的温度监控系统设计%Design of the temperature monitoring system based on ARM

    Institute of Scientific and Technical Information of China (English)

    陈莉莉; 杨雪莹; 周宁轩

    2012-01-01

    提出了一种实时操作系统,采用高速ARM嵌入式微处理器和数字温度传感器(DS18B20)进行的温度采集及监测实验.文中主要采用嵌入式实时操作系统Windows CE作为软件平台,用低功耗、高性能的Samsung公司的32位ARM微处理器S3C2440为主控芯片,以TE2440开发板作为硬件平台,设计了一个温度监控系统.其主要功能模块有温度信号采集模块、ARM控制模块、数据读取模块和显示模块.整个系统使用windows ce操作系统下的EVC编译软件进行设计,采用C++语言编程实现数据的采集、读取、传输以及LCD显示,设计灵活,调试简单.%This thesis designed a sampling stakeout-measure system that based on real-time operation system. It includes a high-speed microprocessor and digital temperature sensor (DS18B20). This design adopt embedded real-time operation system Windows CE as software platform, using 32 bit ARM core processor S3C2440 which is low consumed energy and high reliability as controlling chip, using the TE2440 development board as the hardware platform, designed a temperature monitoring system. Its main function modules are signal pickup module, ARM control module, data reading block and display module. The system uses Windows CE operating system under the EVC compiler software to design, using C++ programming language for data collection, reading, transmission, and LCD display. Meanwhile, it' s very flexibility and easy adjustment.

  12. DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18406369 Regulation of innate immunity by suppressor of cytokine signaling (SOCS)pr...svg) (.html) (.csml) Show Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. ...PubmedID 18406369 Title Regulation of innate immunity by suppressor of cytokine s

  13. Syntheses, structural variations and fluorescence studies of two dinuclear zinc(II) complexes of a Schiff base ligand with an extended carboxylate side arm

    Science.gov (United States)

    Shit, Shyamapada; Sasmal, Ashok; Dhal, Piu; Rizzoli, Corrado; Mitra, Samiran

    2016-03-01

    A potentially tetradentate Schiff base ligand containing carboxylic acid group, HL, (E)-2-((pyridin-2-yl)methyleneamino)-5-chlorobenzoic acid is synthesized and characterized. Reaction of HL with hydrated zinc(II) trichloroacetate and zinc(II) trifluoroacetate under similar reaction condition yields two discrete dinuclear complexes, [Zn(L)(Cl)]2 (1) and [Zn(L)(CF3COO)]2 (2) and characterized by different physicochemical methods. Single crystal X-ray structural characterization reveals different ligating properties of the coordinated anionic ligand (L-) in its zinc(II) complexes. The side arm carboxylate of L- shows μ1,3-carboxylato-bridging mode in 1 and connects zinc(II) atoms in syn-anti fashion while it exhibits a μ1,1-carboxylato-bridging mode in 2. The metal ions display distorted square pyramidal geometries in both the structures and associated with different degrees of distortions. The fluorescence spectra of HL and its zinc(II) complexes recorded in methanol at room temperature which reveal the enhancement of emission intensity for the complexes compared to that of the free ligand. Thermogravimetric analyses (TGA) reveal high thermal stabilities of the complexes.

  14. An Inverter With New Topology and ARM-Based Control%基于ARM的新型拓扑结构的逆变电源

    Institute of Scientific and Technical Information of China (English)

    郑玉莲; 田晓燕; 孙频东

    2012-01-01

    A new topological structure of photovohaic inverter is proposed. It has a simple structure, and has the ability to step up/down conversion and adapt to wide voltage range compared with the one-stage PV grid-connected inverter. Then, one-cycle control based on ARM is introduced with lower power consumption, smaller size and higher accuracy compared with the traditional one-cycle control. Finally, the control strategy is confirmed to be correct and effective by the results of simulation and experiment.%提出了一种光伏逆变电源的新型拓扑结构,该结构简单,相对于单级式并网逆变器具有升、降压的特性,能够适应较宽的电压范围.介绍了基于ARM实现的数字单周期控制,与传统的模拟单周期控制相比,具有功耗更低、体积更小、精确度更高等优点.最后通过仿真和实验验证了该方案的正确性与有效性.

  15. 基于ARM平台的电子海报系统的设计%Design of the Electronic Poster System Based on ARM Platform

    Institute of Scientific and Technical Information of China (English)

    肖思成; 董磊; 查艳芳; 刘正

    2015-01-01

    We designed an electronic poster system based on ARM. It can automatically load USB flash disk and transfer electronic poster files(pictures) from it. Pictures will be unzipped by Libjpg and displayed by Framebuffer. This system can display multi-effects of multi-posters, play music, and compatible with different types of display screen. It is one of the typical application of new media.%本文设计完成的是一款基于ARM平台的电子海报系统的设计。此设计可以实现U盘自动挂载,并从U盘中获取电子海报(即图片),同时通过进程通信实现图片信息的发送和接收。在接收到图片之后可以通过Libjpg进行解压,并通过Framebuffer进行显示。此设计可以实现多张电子海报的多效果展示,音乐的播放,以及不同类型显示屏的显示等功能,是新媒体的典型应用之一。

  16. Design of control for household cleaning robot based on ARM%基于arm的家用清洁机器人的控制系统设计

    Institute of Scientific and Technical Information of China (English)

    张强; 陈奕梅

    2014-01-01

    文章提出了一种基于ARM处理器的家用清洁机器人控制系统,包括硬件设计和软件设计。硬件部分包括主控器模块、电源及欠压检测模、传感器模块、人机交互模块、驱动模块以及清洁模块。软件部分设计了清洁机器人的主要控制流程。该控制系统以通用性和功能完备为目标,使机器人具备智能清洁能力。%This paper presents a kind of control system of home cleaning robot based on ARM processor which includes hardware and software design. The hardware part includes main controller module, power supply with undervoltage detection module, sensor module, human-computer interaction module, driving module and cleaning module. The software part designs the staple control procedure of cleaning robot. This control system aims at universal and integrated functions which ensure the robot have the ability to clean intelligently.

  17. Phase II, two-arm RTOG trial (94-11) of bischloroethyl-nitrosourea plus accelerated hyperfractionated radiotherapy (64.0 or 70.4 Gy) based on tumor volume (> 20 or ≤ 20 cm2, respectively) in the treatment of newly-diagnosed radiosurgery-ineligible glioblastoma multiforme patients

    International Nuclear Information System (INIS)

    Purpose: To compare survivorship, and acute and delayed toxicities following radiation therapy (RT) of radiosurgery-ineligible glioblastoma multiforme (GBM) patients treated with tumor volume-influenced, high-dose accelerated, hyperfractionated RT plus bischloroethyl-nitrosourea (BCNU), using prior RTOG malignant glioblastoma patients as historical controls. Methods and Materials: One hundred four of 108 patients accrued from June 1994 through May 1995 from 26 institutions were analyzable. Patients were histologically confirmed with GBM, and previously untreated. Treatment assignment (52 patients/arm) was based on tumor mass (TM), defined as the product of the maximum diameter and greatest perpendicular dimension of the titanium-gadolinium-enhanced postoperative MRI: Arm A, 64 Gy, TM > 20 cm2; or Arm B, 70.4 Gy, TM ≤ 20 cm2. Both Arms A and B received BCNU (80 mg/m2, under hyperhydration) days 1-3, 56-58, then 4 cycles, each 8 weeks, for a total of 6 treatment series. Results: During the 24 months immediately post-treatment, the overall median survival was 9.1 months in Arm A (64 Gy) and 11.0 months in Arm B (70.4 Gy). Median survival in recursive partitioning analysis (RPA) Class III/IV was 10.4 months in Arm A and 12.2 months in Arm B, while RPA Class V/VI was 7.6 months in Arm A and 6.1 months in Arm B. There were no grade 4 neurological toxicities in Arm A; 2 grade 4 neurological toxicities were observed in Arm B (1 motor deficit, 1 necrosis at 157 days post-treatment). Conclusion: This strategy of high-dose, accelerated hyperfractionated radiotherapy shortens overall RT treatment times while allowing dose escalation, and it provides the potential for combination with currently available, as well as newer, chemotherapy agents. Survival is comparable with previously published RTOG data, and toxicities are within acceptable limits.

  18. SNPase-ARMS qPCR: Ultrasensitive Mutation-Based Detection of Cell-Free Tumor DNA in Melanoma Patients

    OpenAIRE

    Stadler, Julia; Eder, Johanna; Pratscher, Barbara; Brandt, Sabine; Schneller, Doris; Müllegger, Robert; Vogl, Claus; Trautinger, Franz; Brem, Gottfried; Burgstaller, Joerg P.

    2015-01-01

    Cell-free circulating tumor DNA in the plasma of cancer patients has become a common point of interest as indicator of therapy options and treatment response in clinical cancer research. Especially patient- and tumor-specific single nucleotide variants that accurately distinguish tumor DNA from wild type DNA are promising targets. The reliable detection and quantification of these single-base DNA variants is technically challenging. Currently, a variety of techniques is applied, with no appar...

  19. Intelligent Control System for Encapsulation Machine Based on ARM7%基于ARM7的表贴元件包装机智能控制系统

    Institute of Scientific and Technical Information of China (English)

    高岩; 马丽娟

    2008-01-01

    根据我国当前表帖元件包装机温度控制精度及封装效率都较低的现状,设计了基于ARM7处理器S3C44B0X的智能控制系统.介绍了该控制系统的硬件电路组成并给出了主程序流程,针对温度控制提出了带有加权因子的模糊控制算法.实际应用表明,该智能系统的控制效果优于常规控制系统.

  20. 基于ARM7 S3C44BOX嵌入式系统GUI设计%GUI design of embedded system based on ARM7 S3C44BOX

    Institute of Scientific and Technical Information of China (English)

    陈冰峰; 姜卓; 王剑钢

    2004-01-01

    人机界面(GUI)的设计是计算机科学的重要部分,它从系统的一个附属部分已经发展为一门独立的科学,本文所述的GUI设计是应用于嵌入式系统,介绍了硬件平台的搭建(基于ARM7 S3C44BOX),图形平台设计以及虚实屏切换,界面布局,控件设计,窗口刷新等实用技术,具有很强的实用性.

  1. miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling.

    Directory of Open Access Journals (Sweden)

    Aideen S Collins

    Full Text Available Suppressors of cytokine signalling (SOCS proteins are classic inhibitors of the Janus kinase-signal transducer and activator of transcription (JAK-STAT pathway. Many cytokines and pathogenic mediators induce expression of SOCS, which act in a negative feedback loop to inhibit further signal transduction. SOCS mRNA expression is regulated by DNA binding of STAT proteins, however, their post-transcriptional regulation is poorly understood. microRNAs (miRNAs are small non-coding RNAs that bind to complementary sequences on target mRNAs, often silencing gene expression. miR-19a has been shown to regulate SOCS1 expression during mutiple myeloma and be induced by the anti-viral cytokine interferon-(IFN-α, suggesting a role in the regulation of the JAK-STAT pathway. This study aimed to identify targets of miR-19a in the JAK-STAT pathway and elucidate the functional consequences. Bioinformatic analysis identified highly conserved 3'UTR miR-19a target sequences in several JAK-STAT associated genes, including SOCS1, SOCS3, SOCS5 and Cullin (Cul 5. Functional studies revealed that miR-19a significantly decreased SOCS3 mRNA and protein, while a miR-19a antagomir specifically reversed its inhibitory effect. Furthermore, miR-19a-mediated reduction of SOCS3 enhanced IFN-α and interleukin (IL-6 signal transduction through STAT3. These results reveal a novel mechanism by which miR-19a may augment JAK-STAT signal transduction via control of SOCS3 expression and are fundamental to the understanding of inflammatory regulation.

  2. Efficiency enhancement of perovskite solar cells via incorporation of phenylethenyl side arms into indolocarbazole-based hole transporting materials

    Science.gov (United States)

    Petrikyte, Ieva; Zimmermann, Iwan; Rakstys, Kasparas; Daskeviciene, Maryte; Malinauskas, Tadas; Jankauskas, Vygintas; Getautis, Vytautas; Nazeeruddin, Mohammad Khaja

    2016-04-01

    Small-molecule hole transporting materials based on an indolocarbazole core were synthesized and incorporated into perovskite solar cells, which displayed a power conversion efficiency up to 15.24%. The investigated hole transporting materials were synthesized in three steps from commercially available and relatively inexpensive starting materials without using expensive catalysts. Various electro-optical measurements (UV-vis, CV, hole mobility, DSC, TGA, ionization potential) have been carried out to characterize the new hole transporting materials.Small-molecule hole transporting materials based on an indolocarbazole core were synthesized and incorporated into perovskite solar cells, which displayed a power conversion efficiency up to 15.24%. The investigated hole transporting materials were synthesized in three steps from commercially available and relatively inexpensive starting materials without using expensive catalysts. Various electro-optical measurements (UV-vis, CV, hole mobility, DSC, TGA, ionization potential) have been carried out to characterize the new hole transporting materials. Electronic supplementary information (ESI) available: Synthesis procedures, device construction and characterisation details. See DOI: 10.1039/c6nr01275b

  3. SNPase-ARMS qPCR: Ultrasensitive Mutation-Based Detection of Cell-Free Tumor DNA in Melanoma Patients

    Science.gov (United States)

    Stadler, Julia; Eder, Johanna; Pratscher, Barbara; Brandt, Sabine; Schneller, Doris; Müllegger, Robert; Vogl, Claus; Trautinger, Franz; Brem, Gottfried; Burgstaller, Joerg P.

    2015-01-01

    Cell-free circulating tumor DNA in the plasma of cancer patients has become a common point of interest as indicator of therapy options and treatment response in clinical cancer research. Especially patient- and tumor-specific single nucleotide variants that accurately distinguish tumor DNA from wild type DNA are promising targets. The reliable detection and quantification of these single-base DNA variants is technically challenging. Currently, a variety of techniques is applied, with no apparent “gold standard”. Here we present a novel qPCR protocol that meets the conditions of extreme sensitivity and specificity that are required for detection and quantification of tumor DNA. By consecutive application of two polymerases, one of them designed for extreme base-specificity, the method reaches unprecedented sensitivity and specificity. Three qPCR assays were tested with spike-in experiments, specific for point mutations BRAF V600E, PTEN T167A and NRAS Q61L of melanoma cell lines. It was possible to detect down to one copy of tumor DNA per reaction (Poisson distribution), at a background of up to 200 000 wild type DNAs. To prove its clinical applicability, the method was successfully tested on a small cohort of BRAF V600E positive melanoma patients. PMID:26562020

  4. SNPase-ARMS qPCR: Ultrasensitive Mutation-Based Detection of Cell-Free Tumor DNA in Melanoma Patients.

    Directory of Open Access Journals (Sweden)

    Julia Stadler

    Full Text Available Cell-free circulating tumor DNA in the plasma of cancer patients has become a common point of interest as indicator of therapy options and treatment response in clinical cancer research. Especially patient- and tumor-specific single nucleotide variants that accurately distinguish tumor DNA from wild type DNA are promising targets. The reliable detection and quantification of these single-base DNA variants is technically challenging. Currently, a variety of techniques is applied, with no apparent "gold standard". Here we present a novel qPCR protocol that meets the conditions of extreme sensitivity and specificity that are required for detection and quantification of tumor DNA. By consecutive application of two polymerases, one of them designed for extreme base-specificity, the method reaches unprecedented sensitivity and specificity. Three qPCR assays were tested with spike-in experiments, specific for point mutations BRAF V600E, PTEN T167A and NRAS Q61L of melanoma cell lines. It was possible to detect down to one copy of tumor DNA per reaction (Poisson distribution, at a background of up to 200 000 wild type DNAs. To prove its clinical applicability, the method was successfully tested on a small cohort of BRAF V600E positive melanoma patients.

  5. Design and Engineering of a Chess-Robotic Arm

    CERN Document Server

    Elouafiq, Ali

    2012-01-01

    In the scope of the "Chess-Bot" project, this study's goal is to choose the right model for the robotic arm that the "the Chess-Bot" will use to move the pawn from a cell to another. In this paper, there is the definition and the structure of a robot arm. Also, the different engineering and kinematics fundamentals of the robot and its components will be detailed. Furthermore, the different structures of robotic arms will be presented and compared based on different criteria. Finally, a model for "the Chess-Bot" arm will be synthesized based on accurate algorithms and equations.

  6. The long arm of parental addictions: the association with adult children's depression in a population-based study.

    Science.gov (United States)

    Fuller-Thomson, Esme; B Katz, Robyn; T Phan, Vi; P M Liddycoat, Jessica; Brennenstuhl, Sarah

    2013-11-30

    Parental addictions have been associated with adult children's depression in several clinical and population-based studies. However, these studies have not examined if gender differences exist nor have they controlled for a range of potential explanatory factors. Using a regionally representative sample of 6268 adults from the 2005 Canadian Community Health Survey (response rate=83%), we investigated the association between parental addictions and adulthood depression controlling for four clusters of variables: adverse childhood experiences, adult health behaviors, adult socioeconomic status and other stressors. After controlling for all factors, adults exposed to parental addiction had 69% higher odds of depression compared to their peers with non-addicted parents (OR=1.69; 95% CI, 1.25-2.28). The relationship between parental addictions and depression did not vary by gender. These findings underscore the intergenerational consequences of drug and alcohol addiction and reinforce the need to develop interventions that support healthy childhood development. PMID:23642525

  7. Comparison of the clinical accuracy of cervical (C2-C7) pedicle screw insertion assisted by fluoroscopy, computed tomography-based navigation, and intraoperative three-dimensional C-arm navigation

    Institute of Scientific and Technical Information of China (English)

    LIU Ya-jun; TIAN Wei; LIU Bo; LI Qin; HU Lin; LI Zhi-yu; YUAN Qiang; L(U) Yan-wei; SUN Yu-zhen

    2010-01-01

    Background The complicated anatomy of the cervical spine and the variation among pedicles reduces the accuracy and increases the risk of neurovascular complications associated with screw implantation in this region. In this study, we compared the accuracy of cervical (C2-C7) pedicle screw fixation assisted by X-ray fluoroscopy, computed tomography (CT)-based navigation, or intraoperative three-dimensional (3D) C-arm navigation.Methods This prospective cohort study was performed in 82 consecutive patients who underwent cervical pedicle screw fixation. The accuracy of screw insertion was assessed by postoperative CT scan with 3D reconstruction. The accuracy of screw insertion was assessed as: excellent (screw completely within pedicle); acceptable (≤ 1 mm screw outside pedicle cortex); poor (>1 mm screw outside pedicle cortex).Results A total of 145 screws were inserted in 24 patients who underwent C-arm fluoroscopy. Of these, 96 screws (66.2%) were excellent, 37 (25.5%) were acceptable, and 12 (8.3%) were poor. One hundred and fifty-nine screws were inserted in 29 patients in the CT-based navigation group. Among these, 141 (88.7%) were excellent, 14 (8.8%) were acceptable, and 4 (2.5%) were poor. A total of 140 screws were inserted in 29 patients in the intraoperative 3D C-arm navigation group, of which 127 (90.7%) were excellent, and 13 (9.3%) were acceptable. No severe or permanent neurovascular complications associated with screw insertion were observed in any patient.Conclusione CT-based and intraoperative 3D C-arm navigation were similarly accurate, and were both significantly more accurate than C-arm fluoroscopy for guiding cervical pedicle screw fixation. They were able to accurately guide the angle and depth of screw placement using visual 3D images. These two techniques are therefore preferable for high-risk cervical pedicle screw fixation. The ease and convenience of intraoperative 3D C-arm navigation suggests that it may replace virtual

  8. 基于人体工程学的仿人机械臂构型%Configuration of Humanoid Robotic Arm Based on Human Engineering

    Institute of Scientific and Technical Information of China (English)

    赵京; 宋春雨; 杜滨

    2013-01-01

    针对仿人机械臂构型问题,提出一种新的筛选方法,并确定串联结构方式下最符合人臂特征的仿人机械臂构型.从人体解剖学的角度出发,分析人臂的运动机理,并结合人体测量学和机器人学相关原理构建6种不同的仿人机械臂构型.提出全局相对可操作度指标对不同构型进行灵活性分析,并采用可视化方法绘制出各构型的运动灵活性性能分布图.根据人臂的运动特性分析人臂的运动工作空间,将各构型仿人机械臂工作空间与其对比,从而筛选出串联方式下的最佳仿人机械臂构型.该结果为仿人机械臂的设计提供了理论依据,并为后续运动规划奠定了基础.%A new screening method is proposed in configuring humanoid robotic arm,and a series configuration which is most consistent with the human arm characteristics is constructed The morement mechamnsm of human arm from the point of view of human anatomy is analyzed,and 6 types of humanoid robotic arm combined with the mechanism of anthropometry and robotics are constructed.The global relative manipulability index is put forward,and the dexterity of different types of humanoid robotic arm with this index are analyzed.The visualization method is used to plot the image of dexterous performance distribution.The workspaces of human arm are analyzed,and different types of humanoid robotic arm's workspace with it are contrasted,thereby screening the best type of humanoid robotic arm.The results lay the foundation for humanoid robotic arm design and follow-up study of motion planning.

  9. 基于MATLAB的移栽机械臂运动学分析与仿真%Kinematics Analysis and Simulation of Transplanting Robot Arm Based on MATLAB

    Institute of Scientific and Technical Information of China (English)

    胡飞; 尹文庆; 陈彩蓉

    2012-01-01

    为了实现对四自由度移栽机械臂的精确控制,采用D-H法建立机械臂的连杆坐标系和运动学方程,实现了机械臂运动学正解.根据移栽机械臂的特点及参数,用解析法求得移栽机械臂的运动学逆解.运用MATLAB中的Robotics Toolbox工具箱对移栽机械臂进行运动学仿真,验证了所求得的正解和逆解.%In order to control the four - dimension transplanting robot arm accurately, the kinematics equation and the joint coordinate system of robot arm were established by using Denavit - Hartenberg method, and the forward solution of the kinematic equation was solved. According to the characteristics and parameters of transplanting robot arm, the inverse solution of the kinematics equation was solved by using the analytic method. The forward and inverse kinematics solutions of transplanting robot arm were proved by the kinematics simulation with Robotics Toolbox of MATLAB, which provided a theoretical foundation for trajectory planning and precise controlling of transplanting robot arm.

  10. Design of an Error-Based Adaptive Controller for a Flexible Robot Arm Using Dynamic Pole Motion Approach

    Directory of Open Access Journals (Sweden)

    Ki-Young Song

    2011-01-01

    Full Text Available Design of an adaptive controller for complex dynamic systems is a big challenge faced by the researchers. In this paper, we introduce a novel concept of dynamic pole motion (DPM for the design of an error-based adaptive controller (E-BAC. The purpose of this novel design approach is to make the system response reasonably fast with no overshoot, where the system may be time varying and nonlinear with only partially known dynamics. The E-BAC is implanted in a system as a nonlinear controller with two dominant dynamic parameters: the dynamic position feedback and the dynamic velocity feedback. For illustrating the strength of this new approach, in this paper we give an example of a flexible robot with nonlinear dynamics. In the design of this feedback adaptive controller, parameters of the controller are designed as a function of the system error. The position feedback Kp(e,t and the velocity feedback Kv(e,t are continuously varying and formulated as a function of the system error e(t. This approach for formulating the adaptive controller yields a very fast response with no overshoot.

  11. Design of fabric CAD based on ARM%基于ARM的织物CAD软件设计

    Institute of Scientific and Technical Information of China (English)

    刘家希; 王跃存; 马崇启

    2012-01-01

    以Samsung公司的S3C6410为主芯片,Linux为嵌入式系统,Qt/Embedded为用户图形界面构成硬件平台;以Window系统+VMware虚拟机形式提供开发环境,利用Qt软件开发基于ARM平台的织物CAD软件,实现织物组织设计、色纱排列、织物参数设计、系统通讯存储等功能.与传统基于PC平台的织物CAD相比,此系统操作简单,界面友好,具有很强的实用性.%The hardware platform is constituted by Samsung S3C6410 chip, Linux operating system and the interface that is made by Qt/Embedded. A developing environment is provided by the windows system and VMware virtual machine, and the software of textile CAD is developed by using the Qt to complete some functions such as the fabric weave design, yam arrangement, fabric parameter design, communication and storage and so on. Comparing to the traditional software of textile CAD based on PC, this system has the convenience, friendly interface and highly practical.

  12. Dual Arm Work Module Development and Appplications

    Energy Technology Data Exchange (ETDEWEB)

    Noakes, M.W.

    1999-04-25

    The dual arm work module (DAWM) was developed at Oak Ridge National Laboratory (ORNL) by the Robotics Technology Development Program (RTDP) as a development test bed to study issues related to dual arm manipulation, including platform cotilguration, controls, automation, operations, and tooling. The original platform was based on two Schilling Titan II manipulators mounted to a 5-degree-of- freedom (DOF) base fabricated by RedZone Robotics, Inc. The 5-DOF articulation provided a center torso rotation, linear actuation to change the separation between the arms, and arm base rotation joints to provide "elbows up," elbows down," or "elbows out" orientation. A series of tests were conducted on operations, tooling, and task space scene analysis (TSSA)-driven robotics for overhead transporter- mounted and crane hook-deployed scenarios. A concept was developed for DAWM deployment from a large remote work vehicle, but the project was redirected to support dismantlement of the Chicago Pile #5 (CP-5) reactor at Argonne National Laboratory in fiscal year (FY) 1997. Support of CP-5 required a change in focus of the dual arm technology from that of a development test bed to a system focussed for a specific end user. ORNL teamed with the Idaho National Environmental ,Engineering Laboratory, Sandia National Laboratory, and the Savannah River Technology Center to deliver a crane-deployed derivative of the DAWM, designated the dual arm work platform (DAWP). RTDP staff supported DAWP at CP-5 for one FY; Argonne staff continued operation through to dismantlement of the reactor internals. Lessons learned from this interaction were extensive. Beginning in FY 1999, dual arm development activities are again being pursued in the context of those lessons learned. This paper describes the progression of philosophy of the DAWM from initial test bed to lessons learned through interaction at CP-5 and to the present investigation of telerobotic assist of teleoperation and TSSA- driven robotics.

  13. System Design of a Trusted SoC and Detailed Analysis of its Secure State Transitions

    Directory of Open Access Journals (Sweden)

    Xianwen Yang

    2010-11-01

    Full Text Available According to the relevant criterion and principle for designing and evaluating various trusted computing chips, we have proposed a new trusted SoC chip, and have given the implementation of its basic functional modules. In detail, we have discussed the design of the trusted SoC security architecture and the main module functional modules such as microprocessor, cryptographic function module, security management module, input/output interface, along with the most important memory management unit. Moreover, we have discussed reliability of relevant parameters and transfer strategy for trusted root in chip development and application, together with the simulation and validation of corresponding functions. At last, we point out that one of the most important further research directions is the trusted measurement of dynamic data and software running in security environment.

  14. Two-arm master/slave manipulator for nuclear facilities

    International Nuclear Information System (INIS)

    Several kinds of one-arm manipulators have been developed for remote maintenance in nuclear facilities to reduce personnel radiation exposure and to keep plant availability as high as possible. In those maintenance tasks, however, there are many that need two arms, e.g., one arm holds the work object and the other arm cuts it with a plasma torch. To answer this need, a dexterous two-arm master/slave manipulator has been developed based on the technology for one-arm manipulators. A prototype two-arm/slave manipulator is shown. The specifications for master and slave manipulators are listed. The prototype two-arm manipulator is undergoing laboratory performance tests. Preliminary results showed the maximum static operating forces were 0.4 N for the all-direct drive (DD)-type arm and 1.1 N for the semi-DD type. The payload for each arm of the slave manipulator was confirmed as 10 kgf, using mock pieces. The decommissioning tasks of cutting pipes and steel plates were successfully carried out

  15. Implementation of a Capacitor Less Low Dropout Voltage Regulator on Chip (SOC)

    OpenAIRE

    Shailika Sharma; Himani Mittal

    2014-01-01

    — In this paper we have implemented a linear voltage low drop out regulator for efficient power management considering the fact in mind that voltage regulators provide a constant voltage supply to the circuits. We replace the common drain by common source pass element to improve efficiency and reduce the voltage drop across the device. This research paper includes the process to remove the external capacitor allowing for greater power system (soc) application. A compensation scheme is present...

  16. Power proficient Application Specific Communication Infrastructure for Advance SoC

    OpenAIRE

    Naveen Choudhary; Gaur, M.S.; Laxmi, V.

    2011-01-01

    Networks-on-Chip is getting established as acommunication infrastructure for future advance and complexSoC plateforms, composed of a large number of homogenous orheterogeneous processing resources. Application specific SoCdesign presents the prospects for incorporating custom NoCarchitectures that are more suitable for a specific application,and may not be suitable for regular topologies. The precise butoften different communication requirements among IP-cores ofthe SoC call for the design of...

  17. Design of solar PV automatic tracking system based on ARM%基于ARM太阳能光伏板自动跟踪系统的设计

    Institute of Scientific and Technical Information of China (English)

    朱宇; 袁志远

    2013-01-01

    To ARM 11 processor as main control chip embedded photovoltaic automatic control program, from the sunflower solar photovoltaic panels,photo sensitive resistance, photodiode, motor, three-dimensional scaffolds and ARM11. The system through the comparison of photosensitive resistance, combined with the three eye insects recognition direction characteristic, by a ARM 11 system control of multiple motor drive, drive motor rotates automatically, so that a plurality of sunflower solar photovoltaic panels and solar light to maintain the best angle. In order to achieve more than one machine and the automatic tracking sun, the experimental results show that the system can effectively improve the utilization rate of solar energy but also save a lot of cosl.%以ARM 11处理器为主控芯片的嵌入式光伏自动控制方案,由葵花太阳能光伏板,光敏电阻,光电二极管,电机,立体支架和ARM11组成.该系统通过比较光敏电阻的大小,并结合三只眼昆虫识别方向的特点,由一个ARM11系统控制多个电机驱动器,驱动电机自动旋转,使多个葵花太阳能光伏板与太阳光保持最佳角度.从而实现一机多能和对太阳的自动跟踪,实验结果证明该系统不但能有效地提高太阳能的利用率同时还能节约大量的成本.

  18. Arm To Arm Interface Using Embedded C

    Directory of Open Access Journals (Sweden)

    Mohanraj.C

    2013-02-01

    Full Text Available Embedded systems are the most emerging field in these recent years. In this paper a different number of ARM processors (LPC2148 and LPC2378 are interconnected using C for distributed services. N numbers of processors are connected as the network and each processing devices are interlinked with each other, so that the each data that is processed by the devices and it can be used by the other device to activate their entire process. All the processed data’s are communicated to other device through Xbee interface card. LPC2148 and LPC2378 ARM processors are used in this prototype and winXtalk is used as a software terminal window. In this paper, the ultimate benefits of multiple processor interactions related to the embedded applications and design issues of processor interconnection are discussed. The features of multiple processor interaction in inter process communication and executions of embedded multitasking are also discussed. In modern embedded computing platform, embedded processor used in various applications like home automation, industrial control, medical system, access control, etc. In this paper, using embedded processor interactions, the several data communication is established.

  19. Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5.

    Science.gov (United States)

    Sharma, Nikhil; Kumawat, Kanhaiya L; Rastogi, Meghana; Basu, Anirban; Singh, Sunit K

    2016-01-01

    Japanese encephalitis virus (JEV) is a plus strand RNA virus, which infects brain. MicroRNAs are regulatory non-coding RNAs which regulate the expression of various genes in cells. Viruses modulate the expression of various microRNAs to suppress anti-viral signaling and evade the immune response. SOCS (Suppressor of cytokine signalling) family of proteins are negative regulators of anti-viral Jak-STAT pathway. In this study, we demonstrated the regulatory role of SOCS5 in Jak-STAT signaling and its exploitation by JEV through a microRNA mediated mechanism. JEV infection in human brain microglial cells (CHME3) downregulated the expression of miR-432, and upregulated SOCS5 levels. SOCS5 was validated as a target of miR-432 by using 3'UTR clone of SOCS5 in luciferase vector along with miR-432 mimic. The overexpression of miR-432 prior to JEV infection enhanced the phosphorylation of STAT1 resulting into increased ISRE activity and cellular inflammatory response resulting into diminished viral replication. The knockdown of SOCS5 resulted into increased STAT1 phosphorylation and suppressed viral replication. JEV infection mediated downregulation of miR-432 leads to SOCS5 upregulation, which helps the virus to evade cellular anti-viral response. This study demonstrated that JEV utilizes this microRNA mediated strategy to manipulate cellular immune response promoting JEV pathogenesis. PMID:27282499

  20. YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis.

    Science.gov (United States)

    Huang, Zhihui; Wang, Ying; Hu, Guoqing; Zhou, Jiliang; Mei, Lin; Xiong, Wen-Cheng

    2016-05-01

    Yes-associated protein (YAP) is a key transcriptional cofactor of the Hippo pathway, critical for the development of multiple organs. However, its role in the developing brain remains poorly understood. Here, we found that YAP was highly expressed in astrocytes and YAP deletion elevated the astrocytic activation in culture and in vivo, which was associated with microglial activation. At the molecular level, YAP in astrocytes was activated by IFNβ or ciliary neurotrophic factor (CNTF), which was necessary for IFNβ or CNTF induction of the suppressor of cytokine signaling 3 (SOCS3), a negative regulator of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) inflammatory pathway. YAP(-/-)astrocytes thus showed hyperactivation of the JAK-STAT inflammatory pathway and reactive astrogliosis. Expression of SOCS3 in YAP(-/-)astrocytes prevented the hyperactivation of STAT3 and partially restored the astrocytic activation. Finally, reactive astrogliosis was associated with blood-brain barrier dysfunction in YAP brain-selective knockout mice. Taken together, these results identify unrecognized functions of YAP in preventing reactive astrogliosis and reveal a pathway of YAP-SOCS for the negatively control of neuroinflammation. PMID:26679195

  1. Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling

    Directory of Open Access Journals (Sweden)

    Hui Cai

    2016-01-01

    Full Text Available Reducing β amyloid- (Aβ- induced microglial activation is believed to be effective in treating Alzheimer’s disease (AD. Microglia can be activated into classic activated state (M1 state or alternative activated state (M2 state, and the former is harmful; in contrast, the latter is beneficial. Gypenoside (GP is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine. In this study, we hypothesized that GP attenuates Aβ-induced microglial activation by ameliorating microglial M1/M2 states, and the process may be mediated by suppressor of cell signaling protein 1 (SOCS1. In this study, we found that Aβ exposure increased the levels of microglial M1 markers, including iNOS expression, tumor necrosis factor α (TNF-α, interleukin 1β (IL-1β, and IL-6 releases, and coadministration of GP reversed the increase of M1 markers and enhanced the levels of M2 markers, including arginase-1 (Arg-1 expression, IL-10, brain-derived neurotrophic factor (BDNF, and glial cell-derived neurotrophic factor (GDNF releases in the Aβ-treated microglial cells. SOCS1-siRNA, however, significantly abolished the GP-induced effects on the levels of microglial M1 and M2 markers. These findings indicated that GP attenuates Aβ-induced microglial activation by ameliorating M1/M2 states, and the process may be mediated by SOCS1.

  2. Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling.

    Science.gov (United States)

    Cai, Hui; Liang, Qianlei; Ge, Guanqun

    2016-01-01

    Reducing β amyloid- (Aβ-) induced microglial activation is believed to be effective in treating Alzheimer's disease (AD). Microglia can be activated into classic activated state (M1 state) or alternative activated state (M2 state), and the former is harmful; in contrast, the latter is beneficial. Gypenoside (GP) is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine. In this study, we hypothesized that GP attenuates Aβ-induced microglial activation by ameliorating microglial M1/M2 states, and the process may be mediated by suppressor of cell signaling protein 1 (SOCS1). In this study, we found that Aβ exposure increased the levels of microglial M1 markers, including iNOS expression, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 releases, and coadministration of GP reversed the increase of M1 markers and enhanced the levels of M2 markers, including arginase-1 (Arg-1) expression, IL-10, brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) releases in the Aβ-treated microglial cells. SOCS1-siRNA, however, significantly abolished the GP-induced effects on the levels of microglial M1 and M2 markers. These findings indicated that GP attenuates Aβ-induced microglial activation by ameliorating M1/M2 states, and the process may be mediated by SOCS1. PMID:27213058

  3. Development of a Danish national vis—NIR soil spectral library for SOC determination

    DEFF Research Database (Denmark)

    Knadel, Maria; Deng, Fan; Greve, Mogens Humlekrog;

    The development of a soil spectral library is a prerequisite for using vis-NIR spectroscopy for soil analysis. The aim of this study is twofold: (i) to create a Danish national soil library with a main focus on building a model for SOC determination and (ii) to test the feasibility of using the...... library to predict SOC from new dry and moist samples, before and after spiking the library with additional local samples. Soils spectra were obtained using Labspec 5100 (350-2500 nm) vis-NIR sensor. The best validation model resulted in RMSEP value of 0.31, R2 value of 0.79 and RPD value of 2.3. The...... prediction on independent data resulted in very similar results: RMSEP=0.29, R2 of 0.81 and RPD of 2.4. Before spiking the library moderate SOC predictions were obtained for the new dry soils. Prediction on moist samples however, required prior spiking the global library with moist samples from the new...

  4. A configurable and low-power mixed signal SoC for portable ECG monitoring applications.

    Science.gov (United States)

    Kim, Hyejung; Kim, Sunyoung; Van Helleputte, Nick; Artes, Antonio; Konijnenburg, Mario; Huisken, Jos; Van Hoof, Chris; Yazicioglu, Refet Firat

    2014-04-01

    This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly. PMID:24875285

  5. Children In Armed Conflicts

    OpenAIRE

    Ranjan, Tejaswini

    2013-01-01

    This is a descriptive study. A child soldier is a child under the age of 18 that is recruited into the armed forces and engages in political violence. Child Soldiers are recruited by a state or non-state armed group and used as fighters, cooks, suicide bombers, human shields, messengers, spies, or for sexual purposes. This work of research describes the plight of child soldiers taking in context the scenario of different nations. The International mechanisms to combat this problem have also b...

  6. PHENIX Muon Arms

    International Nuclear Information System (INIS)

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons (∼10-3). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described

  7. PHENIX Muon Arms

    Energy Technology Data Exchange (ETDEWEB)

    Akikawa, H.; Al-Jamel, A.; Archuleta, J.B.; Archuleta, J.R.; Armendariz, R.; Armijo, V.; Awes, T.C.; Baldisseri, A.; Barker, A.B.; Barnes, P.D.; Bassalleck, B.; Batsouli, S.; Behrendt, J.; Bellaiche, F.G.; Bland, A.W.; Bobrek, M.; Boissevain, J.G.; Borel, H.; Brooks, M.L.; Brown, A.W.; Brown, D.S.; Bruner, N.; Cafferty, M.M.; Carey, T.A.; Chai, J.-S.; Chavez, L.L.; Chollet, S.; Choudhury, R.K.; Chung, M.S.; Cianciolo, V.; Clark, D.J.; Cobigo, Y.; Dabrowski, C.M.; Debraine, A.; DeMoss, J.; Dinesh, B.V.; Drachenberg, J.L.; Drapier, O.; Echave, M.A.; Efremenko, Y.V.; En' yo, H.; Fields, D.E.; Fleuret, F.; Fried, J.; Fujisawa, E.; Funahashi, H.; Gadrat, S.; Gastaldi, F.; Gee, T.F.; Glenn, A.; Gogiberidze, G.; Gonin, M.; Gosset, J.; Goto, Y.; Granier de Cassagnac, R.; Hance, R.H.; Hart, G.W.; Hayashi, N.; Held, S.; Hicks, J.S.; Hill, J.C.; Hoade, R.; Hong, B.; Hoover, A.; Horaguchi, T.; Hunter, C.T.; Hurst, D.E.; Ichihara, T.; Imai, K.; Isenhower, L.D.L. Davis; Isenhower, L.D.L. Donald; Ishihara, M.; Jang, W.Y.; Johnson, J.; Jouan, D.; Kamihara, N.; Kamyshkov, Y.; Kang, J.H.; Kapoor, S.S.; Kim, D.J.; Kim, D.-W.; Kim, G.-B.; Kinnison, W.W.; Klinksiek, S.; Kluberg, L.; Kobayashi, H.; Koehler, D.; Kotchenda, L.; Kuberg, C.H.; Kurita, K.; Kweon, M.J.; Kwon, Y.; Kyle, G.S.; LaBounty, J.J.; Lajoie, J.G.; Lee, D.M.; Lee, S.; Leitch, M.J.; Li, Z.; Liu, M.X.; Liu, X.; Liu, Y.; Lockner, E.; Lopez, J.D.; Mao, Y.; Martinez, X.B.; McCain, M.C.; McGaughey, P.L.; Mioduszewski, S.; Mischke, R.E.; Mohanty, A.K.; Montoya, B.C.; Moss, J.M.; Murata, J.; Murray, M.M.; Nagle, J.L.; Nakada, Y.; Newby, J.; Obenshain, F.; Palounek, A.P.T.; Papavassiliou, V.; Pate, S.F.; Plasil, F.; Pope, K.; Qualls, J.M.; Rao, G.; Read, K.F. E-mail: readkf@ornl.gov; Robinson, S.H.; Roche, G.; Romana, A.; Rosnet, P.; Roth, R.; Saito, N.; Sakuma, T.; Sandhoff, W.F.; Sanfratello, L.; Sato, H.D.; Savino, R.; Sekimoto, M.; Shaw, M.R.; Shibata, T.-A.; Sim, K.S.; Skank, H.D.; Smith, D.E.; Smith, G.D. [and others

    2003-03-01

    The PHENIX Muon Arms detect muons at rapidities of |y|=(1.2-2.4) with full azimuthal acceptance. Each muon arm must track and identify muons and provide good rejection of pions and kaons ({approx}10{sup -3}). In order to accomplish this we employ a radial field magnetic spectrometer with precision tracking (Muon Tracker) followed by a stack of absorber/low resolution tracking layers (Muon Identifier). The design, construction, testing and expected run parameters of both the muon tracker and the muon identifier are described.

  8. 基于ARM和ZigBee的智能家居系统%Smart home system based on ARM and ZigBee

    Institute of Scientific and Technical Information of China (English)

    吴文忠; 李万磊

    2011-01-01

    For collecting information of equipments and applications, and also transmitting commands, a smart home system based on ARM and ZigBee is designed. The embedded system can control the transmission and data processing. It can interact with Internet and CDMA cellular networks. Users can control the system not only by the embedded terminals, but also the laptop and mobile phone.Finally, experiments on the performance of the ZigBee network organized by house equipments and applications are carried out and tests about the video transmission of the embedded terminals are made. Results show that this system can meet the demands of the common smart home applications.%为了实现家庭设施的智能化控制,提出了一种基于ARM和ZigBee的智能家居系统.该系统通过ZigBee传感器网络采集家居设备信息与传输控制指令,嵌入式系统进行数据的处理与传输,能够实现与CDMA蜂窝网以及Intemet互通,用户既可以通过嵌入式控制平台进行家居系统的控制,又可以通过笔记本电脑与手机等移动设备进行控制.通信仿真和嵌入式样机视频传输性能测试表明,该系统完全能够达到家居系统的一般应用要求.

  9. Design of Image Monitoring System Based on ARM%基于ARM的图像监控系统的开发

    Institute of Scientific and Technical Information of China (English)

    王秀芳; 张昆; 桑圣洁

    2011-01-01

    设计了一种基于ARM和嵌入武Linux操作系统的图像监控系统.以S3C44BOX为核心,通过USB摄像头进行图像的采集,利用JPEG算法将摄像头采集的数据进行压缩编码,采用GPRS无线传输模块将压缩后的信息传输给远程的PC机,通过可视化软件IAbview编写能恢复采集到的图像信息,将图像进行实时的显示和控制的上位机软件.本系统对于数据的采集不局限于固定的地点,并且利用无线传输成功地实现了远程的监控,具有很好的实用价值.%One kind of image monitoring system was designed, which was based on ARM and embedded linux operating system. This system selected the chip S3C44B0X of samsung as core, and implemented image collection by USB camera zooms. After that, condensed the data by JPEG algorithm and transmited this information to remote PC by GPRS modules. The last process was that compiled the software on remote PC machine by Labview,this software can restore picture information and put the pictures for real-time display. This system is not limited to one fixed location for data acquisition, and using the wireless transmission make the remote monitoring come true. It has very good practical value.

  10. Servo control system design based on ARM and CPLD%基于ARM与CPLD的伺服控制系统设计

    Institute of Scientific and Technical Information of China (English)

    邓永停; 李洪文

    2012-01-01

    In order to reduce the complexity of hardware design and improve the real time of the servo control system,the servo controller has been designed based on Samsung's ARM chip S3C2440A and ALTERA's CPLD chip EPM570T144 as the control chip. The function and hardware structure of the controller and software flow has been given. To the turntable the experiment is finished and the controller has good performance through analyzing the experiment data. The experiment shows that the controller has the advantage of high integration,flexible and timing. The controller satisfies the real-time servo control.%为了降低伺服控制系统的硬件设计复杂程度和增强系统控制的实时性,设计了基于ARM和CPLD的多轴伺服电机控制器.该控制器选用三星公司的ARM芯片S3C2440A和ALTERA公司的CPLD芯片EPM570T144作为控制芯片,给出了该控制器的硬件结构和软件流程设计.利用伺服转台进行控制实验,通过对实验数据分析得出该控制器具有较好的控制性能;实验结果表明该伺服控制器能够较好的实现复杂控制算法,具有集成度高,灵活性强,实时性好的特点,满足多轴伺服控制系统实时控制的需要.

  11. Modélisation et Caractérisation d'une Plate-Forme SOC Hétérogène : Application à la Radio Logicielle.

    OpenAIRE

    Rouxel, Samuel

    2006-01-01

    The work of this PhD has been carried out within the framework of the A3S project and relies on component aspects integrated within a SoC platform design methodology, which is based on the UML language. This methodology proposes a high-level design framework based on the A3S UML profile developed to provide real-time embedded system semantic especially in SDR domain. An MDA approach has been considered to deal with different abstraction levels when specifying systems.First part of the work fo...

  12. Experimental validation of flexible robot arm modeling and control

    Science.gov (United States)

    Ulsoy, A. Galip

    1989-01-01

    Flexibility is important for high speed, high precision operation of lightweight manipulators. Accurate dynamic modeling of flexible robot arms is needed. Previous work has mostly been based on linear elasticity with prescribed rigid body motions (i.e., no effect of flexible motion on rigid body motion). Little or no experimental validation of dynamic models for flexible arms is available. Experimental results are also limited for flexible arm control. Researchers include the effects of prismatic as well as revolute joints. They investigate the effect of full coupling between the rigid and flexible motions, and of axial shortening, and consider the control of flexible arms using only additional sensors.

  13. SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

    OpenAIRE

    Elliott, Joanne; Suessmuth, Yvonne; Scott, Linda M.; Nahlik, Krystyna; McMullin, Mary Frances; Constantinescu, Stefan,; Green, Anthony R.; Johnston, James A.

    2009-01-01

    JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 tyrosine phosphorylation was also observed in peripheral blood mononuclear cells and granulocytes isolated from patients with JAK2 H538QK539L or JAY2 F537-K539delinsL mutations. JAK kinase inhibitors...

  14. Crop residue incorporation for increasing SOC stock. Is it worth it?

    Science.gov (United States)

    Pituello, Chiara; Berti, Antonio; Morari, Francesco

    2015-04-01

    In the last fifty years, soil organic carbon (SOC) in North-Eastern Italy decreased at rates ranging from 0.02 to 0.58 t ha/year as a consequence of the intensification and simplification of cropping systems. Most recently, the removal of crop residue for bioenergy production raises concerns about its potential impact on SOC evolution. Crop residue incorporation has been included in the Recommended Management Practices (RMPs) for climate change mitigation, however, several doubts still remain on its actual effectiveness. Indeed, long term effects of residue incorporation on SOC stocks have been studied by many authors with apparently contrasting findings. Thus, given the pivotal role played by SOC on ecosystem services, investigating the effects of residues incorporation on soil quality constitutes a key step towards understanding soil processes and will help establish a rationale bioenergy production policy. For this purpose, soil samples were taken from a long-term field experiment started in 1970, with three types of soil: sand, silt-loam and clay. The experiment design adopted implied a crop rotation including maize, wheat, and potatoes with only two types of residues management: incorporation and removal. The levels of nitrogen application were six (0, 50, 100, 200, 300, 400 kg ha-1) with a factorial combination with the residues management. Residue incorporation affected significantly the carbon stock within the profile (0-70cm), with an average increase in carbon content from 60 to 67 t C ha-1 in 42 years (0.16 t C ha-1 y-1). In clay and silt-loam soils the C stock varied within the whole profile, with an increase in the upper layer (0-20 cm) ranging from 29% (silt-loam) to 60% (clay soil) of the total increment. Conversely, in sand soil the effect was found only in the upper horizon, where the incorporation of residues increased SOC of only 1.9 t ha-1. This indicates that in sand soil the increase of C is mainly attributable to the direct effect of residues

  15. Web-based screening and brief intervention for poly-drug use among teenagers: study protocol of a multicentre two-arm randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Arnaud Nicolas

    2012-09-01

    Full Text Available Abstract Background Mid to late adolescence is characterised by a vulnerability to problematic substance use since the consumption of alcohol and illicit drugs is frequently initiated and increased in this life period. While the detrimental long- and short-term effects of problematic consumption patterns in adolescence pose a major public health concern, current prevention programs targeting alcohol- and other substance-using adolescents are scarce. The study described in this protocol will test the effectiveness of a web-based brief intervention aimed at reducing problematic alcohol use and promoting abstinence from illegal drugs in adolescents with risky substance use aged 16 to 18 years old in four EU-countries. Methods/design To determine the effectiveness of our web-BI, we apply a two-arm randomized controlled trial (RCT study design, with baseline assessment at study entry and a three month follow-up assessment. Adolescents aged 16 to 18 years from Belgium, the Czech Republic, Germany, and Sweden will be randomly assigned to either the fully electronically delivered brief intervention group (N = 400 or an assessment only control group (N = 400 depending on their screening for risky substance use (using the CRAFFT. Recruitment, informed consent, randomization, intervention and follow-up will be implemented online. Primary outcomes are reductions in frequency and quantity of use of alcohol and drugs other than alcohol over a 30 day period, as well as consumption per typical occasion. Secondary outcomes concern changes in substance use related cognitions including the constructs of the Theory of Planned Behaviour, implementation intentions, and stages of change. Moreover the study addresses a number of moderator variables, including age of first use, general psychopathology and quality of parent–child relationship. Discussion The trial is expected to contribute to the growing literature on theory- and web-based brief interventions

  16. Modernization of African Armed Forces

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    2015-01-01

    Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa.......Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa....

  17. Fusion of hand and arm gestures

    Science.gov (United States)

    Coquin, D.; Benoit, E.; Sawada, H.; Ionescu, B.

    2005-12-01

    In order to improve the link between an operator and its machine, some human oriented communication systems are now using natural languages like speech or gesture. The goal of this paper is to present a gesture recognition system based on the fusion of measurements issued from different kind of sources. It is necessary to have some sensors that are able to capture at least the position and the orientation of the hand such as Dataglove and a video camera. Datagloge gives a measure of the hand posture and a video camera gives a measure of the general arm gesture which represents the physical and spatial properties of the gesture, and based on the 2D skeleton representation of the arm. The measurements used are partially complementary and partially redundant. The application is distributed on intelligent cooperating sensors. The paper presents the measurement of the hand and the arm gestures, the fusion processes, and the implementation solution.

  18. ARM Cloud Retrieval Ensemble Data Set (ACRED)

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, C; Xie, S; Klein, SA; McCoy, R; Comstock, JM; Delanoë, J; Deng, M; Dunn, M; Hogan, RJ; Jensen, MP; Mace, GG; McFarlane, SA; O’Connor, EJ; Protat, A; Shupe, MD; Turner, D; Wang, Z

    2011-09-12

    This document describes a new Atmospheric Radiation Measurement (ARM) data set, the ARM Cloud Retrieval Ensemble Data Set (ACRED), which is created by assembling nine existing ground-based cloud retrievals of ARM measurements from different cloud retrieval algorithms. The current version of ACRED includes an hourly average of nine ground-based retrievals with vertical resolution of 45 m for 512 layers. The techniques used for the nine cloud retrievals are briefly described in this document. This document also outlines the ACRED data availability, variables, and the nine retrieval products. Technical details about the generation of ACRED, such as the methods used for time average and vertical re-grid, are also provided.

  19. Design of IPS System Control Based on ARM7 and DSP%基于ARM7和DSP双核控制的逆变电源设计

    Institute of Scientific and Technical Information of China (English)

    唐盛; 姚萌

    2011-01-01

    The main reason of underwater image degradation is backscattering effect of water for light. Backscattering noise elimination is one of the main works of underwater image processing. The causes of generating backscattering noise are analyzed and it is divided into random part and DC part through establishing backscattering noise model of light transmission. Performing Laplacian operation for eliminating the underwater image of DC noise and using Wiener adaptive filter to remove noise again. This method proves that the method can remove the backscattering noise and enhance the image contrast.%为了有效解决逆变电源中存在的因单一复杂控制而带来的系统运行高风险性、控制精度低,反馈调节时间长,系统可扩展性差等缺点,设计实现了一种基于ARM7 Cortex-M3内核的单片机STM32FI03和TI C2000系列DSP芯片TMS320F2808的双核控制逆变电源控制电路.通过在一台6kVA工频双变换纯在线式单相小功率逆变电源上进行控制和负载实验.结果表明,该设计方案有效解决了逆变电源系统中因控制核单一而导致的高复杂度高风险性的缺点,具有控制器模块化,抗干扰能力强,反馈调节速度快,内部接口扩展功能丰富等特点.

  20. The Question and Prospect for the Development of SOC%开发SOC面临的问题及发展展望

    Institute of Scientific and Technical Information of China (English)

    于宗光

    2001-01-01

    The basic concept of SOC is reviewed first. The various questions for the research of SOC are analyzed. The developing strategy of SOC is presented.%在阐述SOC发展背景的基础上,分析了SOC发展面临的各种问题,并提出了我国SOC发展的策略。

  1. 基于PMAC的仿人按摩机器人手臂控制系统设计%Design of arm control system for massage humanoid robotic based on PMAC

    Institute of Scientific and Technical Information of China (English)

    张邦成; 韩跃营; 王占礼; 庞在祥; 张玉玲

    2012-01-01

    The arm of the humanoid massage robot is an important component of the massage robot, which control system is a key factor of the chinese massage robot for achieving precise position control of the massage position.To realize precise position control of the massage humanoid robot arm,the control system of the massage humanoid robot arm was designed based on PC+PMAC.Then the parameters of PMAC were set and the parameters of PID controller were optimized through the communication of PMAC and PC Based on VC++,the control system software was designed.The simulation and practical application results show that the control system of humanoid massage robot arm can fulfill the design requirements.%仿人按摩机器人手臂是按摩机器人的重要组成部分,其控制系统是中医按摩机器人完成按摩位置精确定位的关键因素.为了实现对仿人按摩机器人手臂精确控制,基于PC+PMAC运动控制卡设计了仿人按摩机器人手臂控制系统.通过PC与PMAC运动控制卡之间的通信对PMAC运动控制卡进行参数设置以及PMAC运动控制卡的PID控制器参数的优化.基于VC++软件开发平台设计了控制系统软件.仿真及实际应用效果表明,设计开发的仿人按摩机器人手臂控制系统实现了对手臂的控制,达到了设计要求.

  2. Synthesis and luminescent properties of star-burst D-π-A compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zheng [Department of Applied Chemistry, Nanjing Tech University, Nanjing 210009 (China); Liu, Rui, E-mail: rui.liu@njtech.edu.cn [Department of Applied Chemistry, Nanjing Tech University, Nanjing 210009 (China); Zhu, Xiaolin [Department of Applied Chemistry, Nanjing Tech University, Nanjing 210009 (China); Li, Yuhao [Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433 (China); Chang, Jin [Queensland University of Technology, 2 George St., Brisbane 4000 (Australia); Zhu, Hongjun, E-mail: zhuhjnjut@hotmail.com [Department of Applied Chemistry, Nanjing Tech University, Nanjing 210009 (China); Ma, Liangwei; Lv, Wangjie; Guo, Jun [Department of Applied Chemistry, Nanjing Tech University, Nanjing 210009 (China)

    2014-12-15

    Two new star-burst compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms (1a and 1b) were synthesized and characterized. Their photophysical properties were investigated systematically via spectroscopic and theoretical methods. Both compounds exhibit strong {sup 1}π–π{sup ⁎} transitions in the UV region and intense {sup 1}π–π{sup ⁎}/intramolecular charge transfer ({sup 1}ICT) absorption bands in the UV–vis region. Introducing the carbazole end-capped phenylene ethynylene arm on the 1,3,5-triazine core causes a slight bathochromic shift and enhanced molar extinction coefficient of the {sup 1}π–π{sup ⁎}/{sup 1}ICT transition band. Both compounds are emissive in solution at room temperature and 77 K, which exhibit pronounced positive solvatochromic effect. The emitting state could be ascribed to {sup 1}ICT state in more polar solvent, and {sup 1}π–π{sup ⁎} state in low-polarity solvent. The high emission quantum yields (Φ{sub em}=0.90∼1.0) of 1a and 1b (in hexane and toluene) make them potential candidates as efficient light-emitting materials. The spectroscopic studies and theoretical calculations indicate that the photophysical properties of these compounds can be tuned by the carbazole end-capped phenylene ethynylene arm, which would also be useful for rational design of photofunctional materials. - Highlights: • Star-burst compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms. • Photophysical properties of target compounds were investigated systematically via spectroscopic and theoretical methods. • The relatively high fluorescence quantum yields make them potential candidates as light-emitting materials.

  3. Synthesis and luminescent properties of star-burst D-π-A compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms

    International Nuclear Information System (INIS)

    Two new star-burst compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms (1a and 1b) were synthesized and characterized. Their photophysical properties were investigated systematically via spectroscopic and theoretical methods. Both compounds exhibit strong 1π–π⁎ transitions in the UV region and intense 1π–π⁎/intramolecular charge transfer (1ICT) absorption bands in the UV–vis region. Introducing the carbazole end-capped phenylene ethynylene arm on the 1,3,5-triazine core causes a slight bathochromic shift and enhanced molar extinction coefficient of the 1π–π⁎/1ICT transition band. Both compounds are emissive in solution at room temperature and 77 K, which exhibit pronounced positive solvatochromic effect. The emitting state could be ascribed to 1ICT state in more polar solvent, and 1π–π⁎ state in low-polarity solvent. The high emission quantum yields (Φem=0.90∼1.0) of 1a and 1b (in hexane and toluene) make them potential candidates as efficient light-emitting materials. The spectroscopic studies and theoretical calculations indicate that the photophysical properties of these compounds can be tuned by the carbazole end-capped phenylene ethynylene arm, which would also be useful for rational design of photofunctional materials. - Highlights: • Star-burst compounds based on 1,3,5-triazine core and carbazole end-capped phenylene ethynylene arms. • Photophysical properties of target compounds were investigated systematically via spectroscopic and theoretical methods. • The relatively high fluorescence quantum yields make them potential candidates as light-emitting materials

  4. 基于ARM的远程智能环境监控系统设计%Design of remote intelligent environment monitoring system based on ARM

    Institute of Scientific and Technical Information of China (English)

    马蓉; 李云红; 王晨昊; 兰文博

    2015-01-01

    In the field of complex environment information collection ,stability is always neces‐sary ,and the remote monitoring should be intelligently processed .A set of controllable front‐end equipment was designed ,which is an ARM9 based embedded romote inteilligent environ‐ment monitoring systmem .This system uses a Client/Server(C/S) mode ,where data informa‐tion collection ,video information compression and intelligent processing are achieved in moni‐toring terminal ,and then sent to remote server via WiFi .It can be real‐time dispalyed ,moni‐tored and intelligently processed through the brow ser or client program .Embedded technology and image processing based on motion detection algorithm are combined to realize remote infor‐mation collection and intelligent processing .Test results show that the system is stable ,relia‐ble and more real‐time .It achieves the purpose of intelligent monitoring .And it is convenient to develop multipoint distributed intelligent environmental monitoring .%为了提高复杂现场环境信息采集的稳定性以及远程监控智能化处理的要求,设计一套基于A RM 9的可控前端的嵌入式远程智能环境监控系统。系统方案采用C/S模式,监控端完成数据信息采集、视频信息的压缩编码和智能处理;远程监测中心通过WiFi无线发送到远程服务器,通过浏览器或者客户端程序实时显示监测及智能处理。该系统将嵌入式技术与基于运动检测算法的图像处理技术相结合,实现了远程信息采集与智能处理。测试结果表明,该系统性能稳定可靠、实时性好,达到智能监控的目的,有利于扩展实现多点分布的智能监控系统。

  5. Current Sharing Analysis of Arm Prototype for ITER PF Converter Bridge

    Science.gov (United States)

    Li, Jinchao; Song, Zhiquan; Xu, Liuwei; Fu, Peng; Guo, Bin; Li, Sen; Dong, Lin; Wang, Min

    2014-03-01

    A bridge arm prototype of ITER poloidal field (PF) converter modules has been designed and fabricated. Non-cophase counter parallel connection is chosen as the arm structure of the prototype. Among all factors affecting current sharing, arm structure is the main one. During the design of the arm prototype, a novel method based on inductance matrixes is employed to improve the current sharing of the bridge arm. The test results on the prototype show that the current sharing performance of the arm prototype is much better than relevant design requirement, and that the matrix method is very effective to analyze and solve the current sharing problems of thyristor converters.

  6. Current Sharing Analysis of Arm Prototype for ITER PF Converter Bridge

    International Nuclear Information System (INIS)

    A bridge arm prototype of ITER poloidal field (PF) converter modules has been designed and fabricated. Non-cophase counter parallel connection is chosen as the arm structure of the prototype. Among all factors affecting current sharing, arm structure is the main one. During the design of the arm prototype, a novel method based on inductance matrixes is employed to improve the current sharing of the bridge arm. The test results on the prototype show that the current sharing performance of the arm prototype is much better than relevant design requirement, and that the matrix method is very effective to analyze and solve the current sharing problems of thyristor converters

  7. Effect of crop residue incorporation on soil organic carbon (SOC) and greenhouse gas (GHG) emissions in European agricultural soils

    Science.gov (United States)

    Lehtinen, Taru; Schlatter, Norman; Baumgarten, Andreas; Bechini, Luca; Krüger, Janine; Grignani, Carlo; Zavattaro, Laura; Costamagna, Chiara; Spiegel, Heide

    2014-05-01

    Soil organic matter (SOM) improves soil physical (e.g. increased aggregate stability), chemical (e.g. cation exchange capacity) and biological (e.g. biodiversity, earthworms) properties. The sequestration of soil organic carbon (SOC) may mitigate climate change. However, as much as 25-75% of the initial SOC in world agricultural soils may have been lost due to intensive agriculture (Lal, 2013). The European Commission has described the decline of organic matter (OM) as one of the major threats to soils (COM(2006) 231). Incorporation of crop residues may be a sustainable and cost-efficient management practice to maintain the SOC levels and to increase soil fertility in European agricultural soils. Especially Mediterranean soils that have low initial SOC concentrations, and areas where stockless croplands predominate may be suitable for crop residue incorporation. In this study, we aim to quantify the effects of crop residue incorporation on SOC and GHG emissions (CO2 and N2O) in different environmental zones (ENZs, Metzger et al., 2005) in Europe. Response ratios for SOC and GHG emissions were calculated from pairwise comparisons between crop residue incorporation and removal. Specifically, we investigated whether ENZs, clay content and experiment duration influence the response ratios. In addition, we studied how response ratios of SOM and crop yields were correlated. A total of 718 response ratios (RR) were derived from a total of 39 publications, representing 50 experiments (46 field and 4 laboratory) and 15 countries. The SOC concentrations and stocks increased by approximately 10% following crop residue incorporation. In contrast, CO2 emissions were approximately six times and N2O emissions 12 times higher following crop residue incorporation. The effect of ENZ on the response ratios was not significant. For SOC concentration, the >35% clay content had significantly approximately 8% higher response ratios compared to 18-35% clay content. As the duration of the

  8. SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.

    Science.gov (United States)

    Yu, Cheng-Rong; Kim, Sung-Hye; Mahdi, Rashid M; Egwuagu, Charles E

    2013-11-15

    Suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of the JAK/STAT pathway, and SOCS3 contributes to host immunity by regulating the intensity and duration of cytokine signals and inflammatory responses. Mice with Socs3 deletion in myeloid cells exhibit enhanced STAT3 signaling, expansion of Th1 and Th17 cells, and develop severe experimental autoimmune encephalomyelitis. Interestingly, development of the unique IL-17/IFN-γ double-producing (Th17/IFN-γ and Tc17/IFN-γ) subsets that exhibit strong cytotoxic activities and are associated with pathogenesis of several autoimmune diseases has recently been shown to depend on epigenetic suppression of SOCS3 expression, further suggesting involvement of SOCS3 in autoimmunity and tumor immunity. In this study, we generated mice with Socs3 deletion in the CD4 T cell compartment (CD4-SOCS3 knockout [KO]) to determine in vivo effects of the loss of Socs3 in the T cell-mediated autoimmune disease, experimental autoimmune uveitis (EAU). In contrast to the exacerbation of experimental autoimmune encephalomyelitis in myeloid-specific SOCS3-deleted mice, CD4-SOCS3KO mice were protected from acute and chronic uveitis. Protection from EAU correlated with enhanced expression of CTLA-4 and expansion of IL-10-producing regulatory T cells with augmented suppressive activities. We further show that SOCS3 interacts with CTLA-4 and negatively regulates CTLA-4 levels in T cells, providing a mechanistic explanation for the expansion of regulatory T cells in CD4-SOCS3 during EAU. Contrary to in vitro epigenetic studies, Th17/IFN-γ and Tc17/IFN-γ populations were markedly reduced in CD4-SOCS3KO, suggesting that SOCS3 promotes expansion of the Th17/IFN-γ subset associated with development of severe uveitis. Thus, SOCS3 is a potential therapeutic target in uveitis and other autoinflammatory diseases. PMID:24101549

  9. Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.

    Science.gov (United States)

    Hirschfield, G M; Xie, G; Lu, E; Sun, Y; Juran, B D; Chellappa, V; Coltescu, C; Mason, A L; Milkiewicz, P; Myers, R P; Odin, J A; Luketic, V A; Bacon, B; Bodenheimer, H; Liakina, V; Vincent, C; Levy, C; Pillai, S; Lazaridis, K N; Amos, C I; Siminovitch, K A

    2012-06-01

    We fine mapped two primary biliary cirrhosis (PBC) risk loci, CLEC16A (C-type lectin domain family 16 member A)-suppressor of cytokine signaling 1 (SOCS1) and Spi-B protein (SPIB) and sequenced a locus, sialic acid acetylesterase (SIAE), proposed to harbor autoimmunity-associated mutations. In all, 1450 PBC cases and 2957 healthy controls were genotyped for 84 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and SPIB loci. All 10 exons of the SIAE gene were resequenced in 381 cases and point substitutions of unknown significance assayed for activity and secretion. Fine mapping identified 26 SNPs across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to PBC, the strongest signals at the CLEC16A-SOCS1 locus emanating from a SOCS1 intergenic SNP (rs243325; P=9.91 × 10(-9)) and at the SPIB locus from a SPIB intronic SNP (rs34944112; P=3.65 × 10(-9)). Among the associated SNPs at the CLEC16A-SOCS1 locus, two within the CLEC16A gene as well as one SOCS1 SNP (rs243325) remained significant after conditional logistic regression and contributed independently to risk. Sequencing of the SIAE gene and functional assays of newly identified variants revealed six patients with functional non-synonymous SIAE mutations (Fisher's P=9 × 10(-4) vs controls) We demonstrate independent effects on risk of PBC for CLEC16A, SOCS1 and SPIB variants, while identifying functionally defective SIAE variants as potential factors in risk for PBC. PMID:22257840

  10. Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization.

    Science.gov (United States)

    Helvik, Anne-Sofie; Engedal, Knut; Selbaek, Geir

    2013-01-01

    We studied whether SOC of older adults (≥65 years) without cognitive impairment had changed 1-year after medical hospitalization (T2) and to examine what factors were associated with the change. At baseline (T1) and (T2), the 13-item version of the SOC scale assessed coping, and the Hospital Anxiety and Depression (HAD) Scale assessed symptoms of depression and anxiety. The cognitive state was assessed by means of the mini-mental state examination (MMSE). Physical health was measured with the Charlson Index and functional status with Lawton and Brody's scales for physical self-maintenance (PSMS) and the instrumental activities of daily living (I-ADL). In all, 97 (51 men) persons with a mean age of 75.3 (SD 6.3) years and Mini Mental State Evaluation (MMSE) score of 28.0 (SD 1.6) participated. The SOC improved significantly from baseline to 1-year later (mean 76.5, SD 11.4 vs. mean 79.1, SD 9.1, p≤0.01). Improved SOC was associated with a low SOC at baseline and living without assistance during the study period. The prevalence of depression (HAD-D≥8) and the mean depression (HAD-D) score did not change between the first and second data collection (HAD-D≥8: 3.1% vs. 4.1% and HAD-D score: mean 1.8, SD 2.3 vs. mean 2.4, SD 2.4). However, an improved SOC and reduced anxiety symptoms at the second time point were associated with reduced HAD-D. The mean SOC improved 1-year after hospitalization. The symptoms of depression did not change, but reduction of symptoms of depression at the second time point was associated with improved SOC. PMID:23149225

  11. A mixed SOC-turbulence model for nonlocal transport and Lévy-fractional Fokker–Planck equation

    DEFF Research Database (Denmark)

    Juul Rasmussen, Jens; Milovanov, Alexander V.

    2014-01-01

    self-organized critical (SOC) behavior. Using statistical arguments, it is shown that an amplification mechanism is needed to introduce nonlocality into dynamics. We obtain a consistent derivation of nonlocal Fokker-Planck equation with space-fractional derivatives from a stochastic Markov process with...... the transition probabilities defined in reciprocal space. The hybrid model observes the Sparre Andersen universality and defines a new universality class of SOC. (C) 2014 Elsevier B.V. All rights reserved....

  12. The ARM unpiloted aerospace vehicle (UAV) program

    Energy Technology Data Exchange (ETDEWEB)

    Sowle, D. [Mission Research Corporation, Santa Barbara, CA (United States)

    1995-09-01

    Unmanned aerospace vehicles (UAVs) are an important complement to the DOE`s Atmospheric Radiation Measurement (ARM) Program. ARM is primarily a ground-based program designed to extensively quantify the radiometric and meteorological properties of an atmospheric column. There is a need for airborne measurements of radiative profiles, especially flux at the tropopause, cloud properties, and upper troposphere water vapor. There is also a need for multi-day measurements at the tropopause; for example, in the tropics, at 20 km for over 24 hours. UAVs offer the greatest potential for long endurance at high altitudes and may be less expensive than piloted flights. 2 figs.

  13. Adaptive Control Strategies for Flexible Robotic Arm

    Science.gov (United States)

    Bialasiewicz, Jan T.

    1996-01-01

    The control problem of a flexible robotic arm has been investigated. The control strategies that have been developed have a wide application in approaching the general control problem of flexible space structures. The following control strategies have been developed and evaluated: neural self-tuning control algorithm, neural-network-based fuzzy logic control algorithm, and adaptive pole assignment algorithm. All of the above algorithms have been tested through computer simulation. In addition, the hardware implementation of a computer control system that controls the tip position of a flexible arm clamped on a rigid hub mounted directly on the vertical shaft of a dc motor, has been developed. An adaptive pole assignment algorithm has been applied to suppress vibrations of the described physical model of flexible robotic arm and has been successfully tested using this testbed.

  14. Systems Approach to Arms Control Verification

    Energy Technology Data Exchange (ETDEWEB)

    Allen, K; Neimeyer, I; Listner, C; Stein, G; Chen, C; Dreicer, M

    2015-05-15

    Using the decades of experience of developing concepts and technologies for verifying bilateral and multilateral arms control agreements, a broad conceptual systems approach is being developed that takes into account varying levels of information and risk. The IAEA has already demonstrated the applicability of a systems approach by implementing safeguards at the State level, with acquisition path analysis as the key element. In order to test whether such an approach could also be implemented for arms control verification, an exercise was conducted in November 2014 at the JRC ITU Ispra. Based on the scenario of a hypothetical treaty between two model nuclear weapons states aimed at capping their nuclear arsenals at existing levels, the goal of this exercise was to explore how to use acquisition path analysis in an arms control context. Our contribution will present the scenario, objectives and results of this exercise, and attempt to define future workshops aimed at further developing verification measures that will deter or detect treaty violations.

  15. Parametric Dense Stereovision Implementation on a System-on Chip (SoC)

    Science.gov (United States)

    Gardel, Alfredo; Montejo, Pablo; García, Jorge; Bravo, Ignacio; Lázaro, José L.

    2012-01-01

    This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC) provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps) of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time. PMID:22438742

  16. Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

    Directory of Open Access Journals (Sweden)

    Mignot Emmanuel

    2007-05-01

    Full Text Available Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT and in dogs with a mutation in hypocretin receptor 2 (HCRTR2. However, little is known about molecular alterations downstream of the hypocretin signals. Results By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation, and their unaffected heterozygous siblings. We identified two neuropeptide precursor molecules, Tachykinin precursor 1 (TAC1 and Proenkephalin (PENK, that together with Suppressor of cytokine signaling 2 (SOCS2, showed reduced expression in narcoleptic brains. The difference was particularly pronounced in the amygdala, where mRNA levels of PENK were 6.2 fold lower in narcoleptic dogs than in heterozygous siblings, and TAC1 and SOCS2 showed 4.4 fold and 2.8 fold decrease in expression, respectively. The results obtained from microarray experiments were confirmed by real-time RT-PCR. Interestingly, it was previously shown that a single dose of amphetamine-like stimulants able to increase wakefulness in the dogs, also produce an increase in the expression of both TAC1 and PENK in mice. Conclusion These results suggest that TAC1, PENK and SOCS2 might be intimately connected with the excessive daytime sleepiness not only in dogs, but also in other species, possibly including humans.

  17. STAT3 and SOCS3 expression patterns during murine placenta development

    Directory of Open Access Journals (Sweden)

    S. San Martin

    2013-06-01

    Full Text Available Signal transducers and activators of transcription 3 (Stat3 has been identified as an important signal transducer in the invasive phenotype of the trophoblasts cells in in vitro studies. However, the in situ distribution and patterns of expression of this molecule in trophoblast cells during the development of the placenta are still under-elucidated. Mice uteri of gestational ages between 7 and 14 days of pregnancy (dop were fixed in methacarn and processed with immunoperoxidase techniques for detection of Stat3 and its phosphorylation at serine (p-ser727 residues, as well as the suppressor of cytokine signaling 3 (Socs3 expression. Stat3 was observed at 7 through 9 dop in both the antimesometrial and mesometrial deciduas, while continued immunoreactivity between 10 and 13 dop was seen only in the mesometrial decidua. In the placenta, Stat3 was detected in the cytotrophoblast cells of labyrinth and giant trophoblast cells between 10 and 14 dop. Immunoreactivity for Stat3 was also seen in trophoblast cells surrounding the maternal blood vessels. On days 10 and 11 of pregnancy, p-ser727 was detectable in the mesometrial decidua and in giant trophoblasts, while during 12-14 dop in the spongiotrophoblast region. In addition, Socs3 was immunodetected in maternal and placental tissues, principally in the giant trophoblast cells during the whole period of the study. The present in situ study shows the distribution of Stat3, its serine activation and Socs3 in different maternal and fetal compartments during murine placental development, thus further supporting the idea that they play a role during physiological placentation in mice. 

  18. Parametric Dense Stereovision Implementation on a System-on Chip (SoC

    Directory of Open Access Journals (Sweden)

    Pablo Montejo

    2012-02-01

    Full Text Available This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  19. Metamodeling-driven IP reuse for SoC integration and microprocessor design

    CERN Document Server

    Mathaikutty, Deepak A

    2009-01-01

    This cutting-edge resource offers you an in-depth understanding of metamodeling approaches for the reuse of intellectual properties (IPs) in the form of reusable design or verification components. The books covers the essential issues associated with fast and effective integration of reusable design components into a system-on-a-chip (SoC) to achieve faster design turn-around time. Moreover, it addresses key factors related to the use of reusable verification IPs for a "write once, use many times" verification strategy - another effective approach that can attain a faster product design cycle.

  20. Robot arm apparatus

    Science.gov (United States)

    Nachbar, Henry D.

    1992-01-01

    A robot arm apparatus is provided for inspecting and/or maintaining an interior of a steam generator which has an outside wall and a port for accessing the interior of the steam generator. The robot arm apparatus includes a flexible movable conduit for conveying inspection and/or maintenance apparatus from outside the steam generator to the interior of the steam generator. The flexible conduit has a terminal working end which is translated into and around the interior of the steam generator. Three motors located outside the steam generator are employed for moving the terminal working end inside the steam generator in "x", "y", and "z" directions, respectively. Commonly conducted inspection and maintenance operations include visual inspection for damaged areas, water jet lancing for cleaning sludge deposits, core boring for obtaining sludge deposits, and scrubbing of internal parts.

  1. Microelectromechanical safe arm device

    Energy Technology Data Exchange (ETDEWEB)

    Roesler, Alexander W. (Tijeras, NM)

    2012-06-05

    Microelectromechanical (MEM) apparatus and methods for operating, for preventing unintentional detonation of energetic components comprising pyrotechnic and explosive materials, such as air bag deployment systems, munitions and pyrotechnics. The MEM apparatus comprises an interrupting member that can be moved to block (interrupt) or complete (uninterrupt) an explosive train that is part of an energetic component. One or more latching members are provided that engage and prevent the movement of the interrupting member, until the one or more latching members are disengaged from the interrupting member. The MEM apparatus can be utilized as a safe and arm device (SAD) and electronic safe and arm device (ESAD) in preventing unintentional detonations. Methods for operating the MEM apparatus include independently applying drive signals to the actuators coupled to the latching members, and an actuator coupled to the interrupting member.

  2. Suppressor of Cytokine Signaling (SOCS 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

    Directory of Open Access Journals (Sweden)

    Edmond M Linossi

    Full Text Available Suppressor of Cytokine Signaling (SOCS5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved region in its N-terminus, which we have termed the JAK interaction region (JIR. Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2 autophosphorylation and this function required both the conserved JIR and additional sequences within the long SOCS5 N-terminal region. We further demonstrate that SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3. In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling.

  3. Embedded ARM Control Robotic Arm using BoaWeb server – a Survey

    Directory of Open Access Journals (Sweden)

    V.Sirisha

    2015-10-01

    Full Text Available In today’s market, the competing microprocessors are ARM (Advanced Risc Microprocessor, Intel, AMD. ARM is preferred since it has been powering portable devices for decades and has simple architecture to keep the energy waste to be minimum. The electronics advancements and embedded technology advancements have become a challenging field in today’s techno world. In paper, the diligent features of embedded systems are introduced. It deals about how a robot is controlled using embedded operating system and ARM. Based on the combination of ARM, DSP and ARM Linux, the robot is controlled. The paper introduces development of embedded robot control system using Wi-Fi and also IOT. The embedded control system design includes four aspects. i.e., system structure, functions, hardware design and software design. By using these aspects (hardware and software adjustments, many robotic applications can be developed. Due to the fast execution speed and reasonable Ethernet speed in ARM processor, this system can be used in industrial oriented applications where there is very much necessity of safety and security.

  4. Kiikuv maja / Anu Arm

    Index Scriptorium Estoniae

    Arm, Anu

    2006-01-01

    Eesti Kunstiakadeemia esimese kursuse arhitektuuriüliõpilaste II semestri töö. Juhendaja arhitekt Andres Alver, ehitamise Pedaspeale organiseeris suvepraktika juhendaja arhitekt Jaan Tiidemann. Autor Anu Arm, kaasa töötasid ja valmis ehitasid: Ott Alver, Maarja Elm, Mari Hunt, Alvin Järving, Marten Kaevats, Riho Kerge, Reedik Poopuu, Anu Põime, Helen Rebane, Kaisa Saarva, Martin Tago, Reet Volt. Valmis: 19. VIII 2006

  5. Towards integrating the influence of erosion on within field variability of C input, stock and stability in regional SOC estimates

    Science.gov (United States)

    Meersmans, J.; Quine, T. A.

    2013-12-01

    Improved management of the SOC pool has become an important issue for policymakers in order to maintain soil quality and reduce climate change. Hence, there exists an increased interest in accurate mapping of SOC at the regional scale. Most of these studies are limited to topsoil, consider only factors present at the landscape scale (e.g. climate, land use, soil type) and are at rather coarse resolution. Consequently, the variability of SOC at smaller scales in complex terrain driven by soil erosion, such as stable subsoil carbon buried in depositional areas, is still rather understudied and is not (well) presented in these estimates. Nevertheless, incorporating this smaller level of spatial detail will most probably have a major influence on regional SOC stock dynamics' calculations and mapping. In the present study we aim to unravel the variation in quantity and quality of SOC depth distributions along typical hillslope transects under cropland (Devon, UK) and relate these to soil redistribution rates and variations in C input, i.e. below and above ground biomass productivity. The radionuclide isotope Caesium-137 (137Cs) was used as proxy for erosion. The results show contrasting vertical patterns in SOC stock and stability depending on the rate and type of erosion. For example, sites characterized by deposition due to water erosion (i.e. foot slope) have much higher SOC values near the surface, but show a fast decline with depth, while sites characterized by deposition due to tillage erosion (i.e. most concave position) have moderated SOC surface values that stay constant until a depth of 50 cm, but with increasing stability with depth. The above ground biomass productivity is most linked to water erosion, since we found lowest above ground biomass at the steepest slope position and the highest above ground biomass at the foot slopes. Furthermore, root biomass in the most concave section is significantly higher as compared to any other topo-position. The present

  6. SoC Testing with Network-on-Chip%基于片上网络的系统芯片测试研究

    Institute of Scientific and Technical Information of China (English)

    荆元利; 樊晓桠; 张盛兵; 高德远; 周昔平

    2004-01-01

    This paper introduce the SoC testing, based on the new design methodology Network-on-Chip (NoC). Testing challenges on future SoCs and possible NoC-based solutions are discussed. We put forward test-oriented NoC protocol stacks and test services on the basis of the OSI reference model. Finally, the NoC-based modular testing is introduced.%文章介绍了基于片上网络对系统芯片进行测试的原理和实例,这是一种新的设计方法.首先讨论了未来系统芯片存在的各方面测试挑战,并提出了基于片上网络结构的解决方案.其次,在OSI网络堆栈参考模型的基础上,提出了面向测试的片上网络协议堆栈以及对应的测试服务.最后,介绍了基于片上网络的模块化测试方法.

  7. The implementation and testing of a robotic arm on an autonomous vehicle

    OpenAIRE

    Jun, Hyun Il.

    2007-01-01

    An articulated arm with three degrees of freedom is implemented and tested on an autonomous robot. Kinematic equations of motion for the arm are modeled and tested. A communication architecture is successfully implemented for wireless manual control of the arm. Visual and thermal cues are realized with an onboard camera and a collocated thermal sensor. Future work suggests investigations for full autonomous arm control without manual operator intervention based on sensor cues and visual s...

  8. Observation of self-organized criticality (SOC) behavior during edge biasing experiment on TEXTOR

    International Nuclear Information System (INIS)

    The self-organized criticality (SOC) behavior of the edge plasma transport has been investigated using the fluctuation data measured in the plasma edge and the scrape-off layer of TEXTOR tokamak before and during the edge electrode biasing experiments. In the 'non-shear' discharge phase before biasing, both the potential and density fluctuations clearly exhibit some of the characteristics associated with SOC: (1) existence of f-1 power-law dependence in the frequency spectrum, (2) slowly decaying long tails in the autocorrelation function, (3) values of Hurst parameters larger than 0.5 at all the detected radial locations, (4) non-Gaussian probability density function of fluctuations and (5) radial propagation of avalanche-like events in the edge plasma area. During the biasing phase, with the generation of an edge radial electric field Er and hence a sheared Er x B flow, the local turbulence is found to be well de-correlated by the Er x B velocity shear, consistent with theoretical predictions. Nevertheless, it is concomitantly found that the Hurst parameters are substantially enhanced in the negative flow shear region and in the scrape-off layer as well, which is contrary to theoretical expectation. Implication of these observations to our understanding of plasma transport mechanisms is discussed. (authors)

  9. Superfluid He-explained to SecundoPiaTurins through Self-Organized Criticality/SOC

    Science.gov (United States)

    Maksoed, W. H.

    2015-11-01

    Through Mike Carrell: ``Arata & Zhang/AZ's coldFusion excess Heat & He Production'' normatively describe precedes by Arata & Chang: ``Establishment of the ``solid Fusion'':''..moreover at this time, nuclear fusion reaction was generated inside the solid with synchronous creation of both much 2H4 & thermal Energy''. Nuclear fuel used are ZrO2-Pd(nanoPd), ZrO2.Pd alloy (7[g]) + pure(100%) D2 & Pd-Zr-Ni alloy (18.4[g]) + ... After strange avalanche behavior of superfluid He3 offers a unique `testing ground' for rapid transition, to bioinspired computing, neurobiology & plasma physics quotes: ``SOC is a class of dynamical systems, whose macroscopic behaviour displays the spatial and/or temporal scale-invariance characteristics of a critical point of ``phase transition''-Wikipedia:SOC. Further are e.g to e-Marlin Early Science Meeting offers Secundo Pia Turins devoties, for avalanche dynamic in a pile of rice [V. Frette et al.] & slowly sprinkled to cause ``avalanches'' of Per Bak's sand-Pile experiment at least involving F Lavoise et al.: ``New Methods characterizing Avalanche behavior to determine powder Flow'' 2002 denotes MO Tjia, HL The, Suparno S, Sutrisno: ``Karakterisasi Struktur PP, PS & PVC dengan NMR'', DIP-ITB no. 4872181-1981 to fractions the expenditure in UI/NJOP of Elders-parentals of we Incredible devotes to Prof. Marsongko Hadi/PT.GIRILAYA- Bandung.

  10. Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

    Directory of Open Access Journals (Sweden)

    Francesc Vidal

    Full Text Available BACKGROUND AND AIMS: This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients. METHODS: The study groups were made of 99 patients (efficacy pharmacogenetic substudy and of 114 patients (safety pharmacogenetic substudy. Polymorphisms in the following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 and ITPA were assessed. Genotyping was carried out using Sequenom iPLEX-Gold, a single-base extension polymerase chain reaction. Efficacy end-points assessed were: rapid, early and sustained virological response (RVR, EVR and SVR, respectively. Safety end-points assessed were: anemia, neutropenia, thrombocytopenia, flu-like syndrome, gastrointestinal disturbances and depression. Chi square test, Student's T test, Mann-Whitney U test and logistic regression were used for statistic analyses. RESULTS: As efficacy is concerned, IL28B and CTLA4 gene polymorphisms were associated with RVR (p<0.05 for both comparisons. Nevertheless, only polymorphism in the IL28B gene was associated with SVR (p = 0.004. In the multivariate analysis, the only gene independently associated with SVR was IL28B (OR 2.61, 95%CI 1.2-5.6, p = 0.01. With respect to safety, there were no significant associations between flu-like syndrome or depression and the genetic variants studied. Gastrointestinal disturbances were associated with ITPA gene polymorphism (p = 0.04. Anemia was associated with OAS1 and CTLA4 gene polymorphisms (p = 0.049 and p = 0.045, respectively, neutropenia and thromobocytopenia were associated with SOCS3 gene polymorphism (p = 0.02 and p = 0.002, respectively. In the multivariate analysis, the associations of the SOCS3 gene polymorphism with neutropenia (OR 0.26, 95%CI 0

  11. Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.

    Directory of Open Access Journals (Sweden)

    Antje Fischer-Rosinsky

    Full Text Available BACKGROUND: The suppressor of cytokine signalling 3 (SOCS3 provides a link between cytokine action and their negative consequences on insulin signalling. Thus SOCS3 is a potential candidate gene for type 2 diabetes (T2DM. METHODOLOGY/PRINCIPAL FINDINGS: Based on HapMap we identified the polymorphism A+930-->G (rs4969168 as a haplotype tagging SNP (htSNP sufficiently covering the genetic variation of the whole gene. We therefore examined the association between rs4969168 within SOCS3 and T2DM in three independent study populations; one prospective case-cohort study and two cross-sectional study populations. Due to the low frequency of individuals being homozygous for the polymorphism a dominant model of inheritance was assumed. The case-cohort study with 2,957 individuals (764 of them with incident T2DM showed no effect of the polymorphism on diabetes risk (hazard ratio (95%CI: 0.86 (0.66-1.13; p = 0.3. Within the MeSyBePo-study population 325 subjects had T2DM from a total of 1,897 individuals, while the second cross-sectional cohort included 851 cases of T2DM within a total of 1653 subjects. According to the results in the prospective study, no association with T2DM was found (odds ratio (95%CI: 0.78 (0.54-1.12 for MesyBepo and 1.13 (0.90-1.42 for the Leipzig study population. There was also no association with metabolic subtraits such as insulin sensitivity (p = 0.7, insulin secretion (p = 0.8 or the hyperbolic relation of both, the disposition index (p = 0.7. In addition, no evidence for interaction with BMI or sex was found. We subsequently performed a meta-analysis, additionally including the publicly available data from the T2DM-subcohort of the WTCCC (n = 4,855. The overall odds ratio within that meta-analysis was 0.96 (0.88-1.06. CONCLUSIONS/SIGNIFICANCE: There is no strong effect of the common genetic variation within the SOCS3 gene on the development of T2DM.

  12. A Unified Approach for Reporting ARM Measurement Uncertainties Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Campos, E [Argonne National Laboratory; Sisterson, DL [Argonne National Laboratory

    2015-10-01

    The Atmospheric Radiation Measurement (ARM) Climate Research Facility is observationally based, and quantifying the uncertainty of its measurements is critically important. With over 300 widely differing instruments providing over 2,500 datastreams, concise expression of measurement uncertainty is quite challenging. The ARM Facility currently provides data and supporting metadata (information about the data or data quality) to its users through a number of sources. Because the continued success of the ARM Facility depends on the known quality of its measurements, the Facility relies on instrument mentors and the ARM Data Quality Office (DQO) to ensure, assess, and report measurement quality. Therefore, an easily-accessible, well-articulated estimate of ARM measurement uncertainty is needed.

  13. 猪SOSC1、SOCS3和SOCS4基因克隆及组织表达研究%Suppressor of cytokine signaling 1, 3 and 4 genes in pigs (Sus scrofa) :cDNA cloning and tissue expression

    Institute of Scientific and Technical Information of China (English)

    段庆梓; 何夏萍; 吕学斌; 李娟; 王亚军

    2012-01-01

    Using cDNA of Landrace pig brain as the template, the full-length cDNAs of SOCS-1, SOCS-3. and SOCS-4 genes were cloned. Moreover, a pseudo-SOCS-3 gene was cloned using Landrace genom-ic DNA as template. SOCS-1 cDNA encodes a protein precursor of 220 amino acids, which shares high amino acid sequence identity with that of human (94%), rat (91%), mouse (91%), cattle (94%). SOCS-3 cDNA (690bp) encodes a protein precursor of 229 amino acids, which shares high amino acid sequence identity (> 94%) with that of mammals. The full-length cDNA of SOCS-4 encodes a protein precursor of 441 amino acids which shares high amino acid sequence identity with that of human (97%) , rat (89%) and mouse (86%). Further structural analyses indicate that pig SOCS-1, SOCS-3 and SOCS-4 contain an SH2 domain and a C-terminal SOCS box domain; SOCS-4 contains a large amino-terminus of 285 amino acids with no identifiable protein-interaction motifs. Using RT-PCR assay, the mRNA expression of SOCS-1, SOCS-3, and SOCS4 genes were also examined in adult pig tissues. The results showed that they were widely expressed in all of the tissues examined.%本文以长白猪(Landrace)大脑cDNA为模板,克隆得到长白猪细胞因子抑制因子SOCS-3基因,并首次克隆得到长白猪SOCS-1和SOCS-4基因.此外,还利用长白猪基因组DNA为模板克隆得到SOCS-3假基因(pseudo-SOCS-3).序列分析显示:长白猪SOCS-1基因cDNA编码220个氨基酸的前体蛋白,与人、小鼠、大鼠和牛的氨基酸序列一致性分别为94%、91%、91%和94%;SOCS-3基因cDNA全长690 bp,编码229个氨基酸的前体蛋白,与人、大鼠和小鼠的氨基酸序列一致性高达94%以上;SOCS-4基因cDNA全长1404 bp,整个编码区没有内含子插入,编码441个氨基酸的前体蛋白,与人、大鼠和小鼠的氨基酸序列一致性分别为97%,89%和86%.氨基酸结构分析显示,长白猪SOCS-1,SOCS-3和SOCS-4基因都具有典型的中央SH2结构域和C末端有40个氨基酸的SOCS

  14. Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.

    Science.gov (United States)

    Jin, Duo; Liu, Yuanyuan; Sun, Fang; Wang, Xuhua; Liu, Xuefeng; He, Zhigang

    2015-01-01

    The limited rewiring of the corticospinal tract (CST) only partially compensates the lost functions after stroke, brain trauma and spinal cord injury. Therefore it is important to develop new therapies to enhance the compensatory circuitry mediated by spared CST axons. Here by using a unilateral pyramidotomy model, we find that deletion of cortical suppressor of cytokine signaling 3 (SOCS3), a negative regulator of cytokine-activated pathway, promotes sprouting of uninjured CST axons to the denervated spinal cord. A likely trigger of such sprouting is ciliary neurotrophic factor (CNTF) expressed in local spinal neurons. Such sprouting can be further enhanced by deletion of phosphatase and tensin homolog (PTEN), a mechanistic target of rapamycin (mTOR) negative regulator, resulting in significant recovery of skilled locomotion. Ablation of the corticospinal neurons with sprouting axons abolishes the improved behavioural performance. Furthermore, by optogenetics-based specific CST stimulation, we show a direct limb motor control by sprouting CST axons, providing direct evidence for the reformation of a functional circuit. PMID:26598325

  15. Kinematic feedback control laws for generating natural arm movements

    International Nuclear Information System (INIS)

    We propose a stochastic optimal feedback control law for generating natural robot arm motions. Our approach, inspired by the minimum variance principle of Harris and Wolpert (1998 Nature 394 780–4) and the optimal feedback control principles put forth by Todorov and Jordan (2002 Nature Neurosci. 5 1226–35) for explaining human movements, differs in two crucial respects: (i) the endpoint variance is minimized in joint space rather than Cartesian hand space, and (ii) we ignore the dynamics and instead consider only the second-order differential kinematics. The feedback control law generating the motions can be straightforwardly obtained by backward integration of a set of ordinary differential equations; these equations are obtained exactly, without any linear–quadratic approximations. The only parameters to be determined a priori are the variance scale factors, and for both the two-DOF planar arm and the seven-DOF spatial arm, a table of values is constructed based on the given initial and final arm configurations; these values are determined via an optimal fitting procedure, and consistent with existing findings about neuromuscular motor noise levels of human arm muscles. Experiments conducted with a two-link planar arm and a seven-DOF spatial arm verify that the trajectories generated by our feedback control law closely resemble human arm motions, in the sense of producing nearly straight-line hand trajectories, having bell-shaped velocity profiles, and satisfying Fitts Law. (paper)

  16. Optimization-Based Design of a Small Pneumatic-Actuator-Driven Parallel Mechanism for a Shoulder Prosthetic Arm with Statics and Spatial Accessibility Evaluation

    OpenAIRE

    Masashi Sekine; Kento Sugimori; Jose Gonzalez; Wenwei Yu

    2013-01-01

    Human arms undertake most tasks in the activities of daily living (ADLs). When designing shoulder prostheses for high‐level upper‐limb amputees, we should consider not only how to realize high degrees of freedom under weight and shape constraints but also the user’s individual task space in daily life. An appropriate mechanical structure that can make full use of state‐of‐the‐art actuators and a scheme to optimize the structure’s configuration to match users’ spatial access and manipulability...

  17. Disarmament and arms control

    International Nuclear Information System (INIS)

    This report discusses how far science and technology can provide methods of making arms control and disarmament agreements more controlable in an objective way. Two case studies have been considered, the test ban treaty and the verification of the number of strategic nuclear weapons. These lead to the conclusion that both science and politics are closely interwoven and that within what appear to be scientific arguments, political positions are being defended. Consequently scientists and technologists and the contexts in which they work, play a prominent role. (C.F.)

  18. Removable molar power arm

    OpenAIRE

    2013-01-01

    Attachment of force elements from the gingival hook of maxillary molar tubes during the retraction of the anterior teeth is very common in orthodontic practice. As the line of force passes below the center of resistance (CR) of molar, it results its mesial tipping and also anchorage loss. To overcome this problem, the line of force should pass along the CR of molar. This article highlights a method to overcome this problem by attaching a removable power arm to the headgear tube of molar tube ...

  19. 'Raise your arm if you think it makes a difference ! Arms-up versus arms-down position for myocardial perfusion studies

    International Nuclear Information System (INIS)

    Full text: The need for myocardial perfusion studies (MPS) using technetium based agents to be performed in the arms-up position has recently been questioned. We have decided to test the hypothesis that studies can be performed in the arms-down position without an increase in the number of perfusion defects demonstrated. MPS were performed in 24 patients in three practice locations for detection of coronary artery disease or assessment of known disease. In each patient either the stress (S) or rest (R) study was performed in both arms-up and arms-down positions. Each study was interpreted blindly by two experienced nuclear medicine physicians (A and B), and each of eight myocardial segments was graded on a five point scale from normal to markedly abnormal. Comparisons were performed for the number and severity of defects between the pairs of studies, and between physician A and B. For simplicity the results have been re-grouped into normal/equivocal and abnormal (mild/moderate/ marked). In conclusion in this pilot study considerable discordance is noted between the arms-up and arms-down studies. Contrary to some reports, our findings indicate that performing MPS in the arms-down position will introduce errors in the reporting process. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  20. The Norma arm region Chandra survey catalog: X-ray populations in the spiral arms

    Energy Technology Data Exchange (ETDEWEB)

    Fornasini, Francesca M. [Astronomy Department, University of California, 601 Campbell Hall, Berkeley, CA 94720 (United States); Tomsick, John A.; Bodaghee, Arash; Krivonos, Roman A. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720 (United States); An, Hongjun [Department of Physics, McGill University, Rutherford Physics Building, 3600 University Street, Montreal, QC H3A 2T8 (Canada); Rahoui, Farid [European Southern Observatory, Karl Schwarzschild-Strasse 2, D-85748 Garching bei München (Germany); Gotthelf, Eric V. [Columbia Astrophysics Laboratory, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Bauer, Franz E. [Instituto de Astrofísica, Facultad de Física, Pontificia Universidad Católica de Chile, 306, Santiago 22 (Chile); Stern, Daniel, E-mail: f.fornasini@berkeley.edu [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, MS 169-506, Pasadena, CA 91109 (United States)

    2014-12-01

    We present a catalog of 1415 X-ray sources identified in the Norma Arm Region Chandra Survey (NARCS), which covers a 2° × 0.°8 region in the direction of the Norma spiral arm to a depth of ≈20 ks. Of these sources, 1130 are point-like sources detected with ≥3σ confidence in at least one of three energy bands (0.5-10, 0.5-2, and 2-10 keV), five have extended emission, and the remainder are detected at low significance. Since most sources have too few counts to permit individual classification, they are divided into five spectral groups defined by their quantile properties. We analyze stacked spectra of X-ray sources within each group, in conjunction with their fluxes, variability, and infrared counterparts, to identify the dominant populations in our survey. We find that ∼50% of our sources are foreground sources located within 1-2 kpc, which is consistent with expectations from previous surveys. Approximately 20% of sources are likely located in the proximity of the Scutum-Crux and near Norma arm, while 30% are more distant, in the proximity of the far Norma arm or beyond. We argue that a mixture of magnetic and nonmagnetic cataclysmic variables dominates the Scutum-Crux and near Norma arms, while intermediate polars and high-mass stars (isolated or in binaries) dominate the far Norma arm. We also present the cumulative number count distribution for sources in our survey that are detected in the hard energy band. A population of very hard sources in the vicinity of the far Norma arm and active galactic nuclei dominate the hard X-ray emission down to f{sub X} ≈ 10{sup –14} erg cm{sup –2} s{sup –1}, but the distribution curve flattens at fainter fluxes. We find good agreement between the observed distribution and predictions based on other surveys.

  1. The Norma arm region Chandra survey catalog: X-ray populations in the spiral arms

    International Nuclear Information System (INIS)

    We present a catalog of 1415 X-ray sources identified in the Norma Arm Region Chandra Survey (NARCS), which covers a 2° × 0.°8 region in the direction of the Norma spiral arm to a depth of ≈20 ks. Of these sources, 1130 are point-like sources detected with ≥3σ confidence in at least one of three energy bands (0.5-10, 0.5-2, and 2-10 keV), five have extended emission, and the remainder are detected at low significance. Since most sources have too few counts to permit individual classification, they are divided into five spectral groups defined by their quantile properties. We analyze stacked spectra of X-ray sources within each group, in conjunction with their fluxes, variability, and infrared counterparts, to identify the dominant populations in our survey. We find that ∼50% of our sources are foreground sources located within 1-2 kpc, which is consistent with expectations from previous surveys. Approximately 20% of sources are likely located in the proximity of the Scutum-Crux and near Norma arm, while 30% are more distant, in the proximity of the far Norma arm or beyond. We argue that a mixture of magnetic and nonmagnetic cataclysmic variables dominates the Scutum-Crux and near Norma arms, while intermediate polars and high-mass stars (isolated or in binaries) dominate the far Norma arm. We also present the cumulative number count distribution for sources in our survey that are detected in the hard energy band. A population of very hard sources in the vicinity of the far Norma arm and active galactic nuclei dominate the hard X-ray emission down to fX ≈ 10–14 erg cm–2 s–1, but the distribution curve flattens at fainter fluxes. We find good agreement between the observed distribution and predictions based on other surveys.

  2. Electromotive Potential Distribution and Electronic Leak Currents in Working YSZ Based SOCs

    DEFF Research Database (Denmark)

    Mogensen, Mogens Bjerg; Jacobsen, Torben

    2009-01-01

    The size of electronic leak currents through the YSZ electrolyte of solid oxide cells have been calculated using basic solid state electrochemical relations and literature data. The distribution of the electromotive potential, of Galvani potential, of concentration of electrons, e, and electron...... holes, h, was also calculated as these parameters are the basis for the understanding of the electronic conductivity that causes the electronic leak currents. The results are illustrated with examples. The effects of electrolyte thickness, temperature and cell voltage on the electronic leak current...

  3. A REAL-TIME REMOTE CONTROL AND MONITORING SYSTEM USING ZYNQ SOC FPGA BASED WEB SERVER

    OpenAIRE

    M. A. Majeed*, B. Vamsi Krishna, Dr.M. Kama Raju

    2016-01-01

    For the economic development and progress of any country, roads play an important role by providing transportation ease for goods as well as for passengers. The number of vehicles on road is increasing day by day which are controlled by the traditional Traffic Light Controller in the countries like India and other developing countries. In traditional Traffic Light Control system, fixed time is allotted for traffic on each road to pass irrespective of the traffic density. This is an inefficien...

  4. 基于ARM的非接触式安全驾驶预警系统%ARM-based Non-contact Safe Driving Warning System

    Institute of Scientific and Technical Information of China (English)

    严海玉; 杨会成; 宋一博; 张慧; 漏鸣杰; 韩康

    2014-01-01

    本系统采用非接触法,使用CMOS摄像头OV3640模块采集图像,以ARM11开发板和Linux操作系统为开发平台,结合开源计算机视觉库OpenCV来加快运行速度和降低使用成本,采用QT编写代码设计了用户界面GUI,方便用户实时操作。实现了疲劳状况的检测和预警。%The present system uses a non-contact method, using CMOS camera OV3640 module to capture images, uses ARM11 development board and Linux operating systems as the development platform, combines with the open source computer vision library OpenCV to accelerate the operation speed and reduce the cost, uses QT writing code to design user interface GUI for user-friendly real-time operation. The system achieves the detection and warning of fatigue conditions.

  5. ARM-based Non-contact Safe Driving Warning System%基于ARM的非接触式安全驾驶预警系统

    Institute of Scientific and Technical Information of China (English)

    严海玉; 杨会成; 宋一博; 张慧; 漏鸣杰; 韩康

    2014-01-01

    The present system uses a non-contact method, using CMOS camera OV3640 module to capture images, uses ARM11 development board and Linux operating systems as the development platform, combines with the open source computer vision library OpenCV to accelerate the operation speed and reduce the cost, uses QT writing code to design user interface GUI for user-friendly real-time operation. The system achieves the detection and warning of fatigue conditions.%本系统采用非接触法,使用CMOS摄像头OV3640模块采集图像,以ARM11开发板和Linux操作系统为开发平台,结合开源计算机视觉库OpenCV来加快运行速度和降低使用成本,采用QT编写代码设计了用户界面GUI,方便用户实时操作。实现了疲劳状况的检测和预警。

  6. 基于ARM的四足机器人分层控制系统%Hierarchy Control System of Quadruped Robot Based on ARM

    Institute of Scientific and Technical Information of China (English)

    彭为; 蒋蓁; 董金秋

    2011-01-01

    For good control of the quadruped robot with walking and skating abilities and for implementation of expansibility of modularization and function of the robot, a hierarchy system is adopted to control the robot. A MCU is used for real time driving control of the actuator and ARM9 used for sensor information acquisition and processing. The design of graphic interfaces is carried out on the PC with the help of VC++.%为了实现时具有步行、滑行复合运动的四足机器人的良好控制.实现该机器人的模块化和功能的扩展性,采用了分层控制体系架构来实现机器人的控制.使用单片机来实现舵机的实时驱动控制.使用ARM9实现传感器的采集和信息的处理,在PC机上利用VC++实现图形界面的设计.

  7. X-Armed Bandits

    CERN Document Server

    Bubeck, Sébastien; Stoltz, Gilles; Szepesvari, Csaba

    2010-01-01

    We consider a generalization of stochastic bandits where the set of arms, $\\cX$, is allowed to be a generic measurable space and the mean-payoff function is "locally Lipschitz" with respect to a dissimilarity function that is known to the decision maker. Under this condition we construct an arm selection policy, called HOO hierarchical optimistic optimization), with improved regret bounds compared to previous results for a large class of problems. In particular, our results imply that if $\\cX$ is the unit hypercube in a Euclidean space and the mean-payoff function has a finite number of global maxima around which the behavior of the function is locally H\\"older continuous with a known exponent, then the expected of HOO regret is bounded up to a logarithmic factor by $\\sqrt{n}$, i.e., the rate of growth of the regret is independent of the dimension of the space. We also prove the minimax optimality of our algorithm when the dissimilarity is a metric.

  8. Report of the SocMon capacity development workshop for the Bay of Bengal Large Marine Ecosystem countries in South Asia, Vidathaltivu, Northern Province, Sri Lanka, 3-11 March, 2015

    OpenAIRE

    Hoon, V.; Saleem, M.; Marirajan, T.; Townsley, P.

    2015-01-01

    This Socioeconomic Monitoring (SocMon) training workshop was coordinated by the Small Fisher Federation of Lanka (SFFL). Planned outputs included: participants from Mannar trained in SocMon methodologies; draft SocMon reports fro Vidathaltivu; a workplan for Mannar; a communication strategy for Vidathaltivu/ Mannar; and key inputs to a regional SocMon strategy

  9. Thermoelectric Modeling and Online SOC Estimation of Li-Ion Battery for Plug-In Hybrid Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Aishwarya Panday

    2016-01-01

    Full Text Available The increasing oil price, energy demand, and environmental concern are leading to a global switch towards Plug-In Hybrid Electric Vehicles (PHEVs. In a PHEV, Li-ion battery is considered as the primary propelling source. Therefore, an accurate battery model is required to predict the I-V characteristic and dynamic behavior of a battery. This paper presents a highly effective thermoelectric model of Li-ion battery developed in Simulink. An algorithm is proposed for estimation of state of charge (SOC and open circuit voltage (OCV adaptively to notify the exact SOC level for better utilization of battery power and optimal vehicle performance. Thermal behavior of Li-ion battery is investigated for wide temperature range and its effect on resistance, capacity, and OCV is recorded. The minimum SOC level to which battery can get depleted is calculated using gradient method. The proposed simulation results are analyzed with those of earlier models and found to be better.

  10. Application of LabSOCS efficiency calibration method in rapid analysis at lab under emergency monitoring of the nuclear incidents

    International Nuclear Information System (INIS)

    Objective: To explore the effectiveness of the method of LabSOCS(Laboratory sourceless calibration software) efficiency calibration in laboratory rapid analysis for emergency monitoring of nuclear incidents. Methods: The detection efficiency of three kinds of environmental samples in emergency monitoring Wag calculated by using the LabSOCS efficiency calibration method, and compared with the values that were obtained by way of radioactive source calibration method. Results: The maximum relative deviation of the detection efficiency between the two methods was less than 15%, and the values with relative deviation less than 5% accounted for 70%. Conclusions: The LabSOCS efficiency calibration method might take the place of radioactive source efficiency calibration method, and meet the requirement of rapid analysis in emergency monitoring of the nuclear incidents. (authors)

  11. Analytical forms of chaotic spiral arms

    Science.gov (United States)

    Harsoula, M.; Efthymiopoulos, C.; Contopoulos, G.

    2016-07-01

    We develop an analytical theory of chaotic spiral arms in galaxies. This is based on the Moser theory of invariant manifolds around unstable periodic orbits. We apply this theory to the chaotic spiral arms, which start from the neighbourhood of the Lagrangian points L1 and L2 at the end of the bar in a barred-spiral galaxy. The series representing the invariant manifolds starting at the Lagrangian points L1, L2, or unstable periodic orbits around L1 and L2, yield spiral patterns in the configuration space. These series converge in a domain around every Lagrangian point, called `Moser domain', and represent the orbits that constitute the chaotic spiral arms. In fact, these orbits are not only along the invariant manifolds, but also in a domain surrounding the invariant manifolds. We show further that orbits starting outside the Moser domain but close to it converge to the boundary of the Moser domain, which acts as an attractor. These orbits stay for a long time close to the spiral arms before escaping to infinity.

  12. Implementation of a Capacitor Less Low Dropout Voltage Regulator on Chip (SOC

    Directory of Open Access Journals (Sweden)

    Shailika Sharma

    2014-06-01

    Full Text Available — In this paper we have implemented a linear voltage low drop out regulator for efficient power management considering the fact in mind that voltage regulators provide a constant voltage supply to the circuits. We replace the common drain by common source pass element to improve efficiency and reduce the voltage drop across the device. This research paper includes the process to remove the external capacitor allowing for greater power system (soc application. A compensation scheme is presented that provides both a fast transient response and full range alternating current (ac stability from 0 to 50 mA load current even if the output load is as high as 100 pf. A 2.7-v capacitorless LDO voltage regulator with a power supply 3 v was designed with a dropout voltage of 300 mv.

  13. Soc stock in different forest-related land-uses in central Stara planina mountain, Bulgaria

    Directory of Open Access Journals (Sweden)

    Zhiyanski Miglena

    2009-01-01

    Full Text Available Forest conversions may lead to an accumulation of carbon in vegetation, but little is known about changes in soil C storage with establishment of plantation forests. Understanding these effects is important to addressing issues relevant to ecosystem function and productivity, and to global balance of carbon. The study investigated the effects of the created coniferous plantations on former beech and pasture sites on the soil organic carbon storage. The major forest-related land-uses in the high mountainous regions of central Stara Planina Mountain were investigated: mountainous pasture, coniferous plantations (planted on previous pasture and beech forests between four and five decades ago and natural beech forests. The experimental data of soil properties, conducted in 2005, 2006 and 2007, were used in determining the variations in organic carbon storage in forest litter and in mineral soil under different land-use patterns. At each site five representative soil profiles were opened and described giving a total 75 soil samples from the soil layers respectively at 0-10, 10-30 and 30-50 cm depth. A total of 55 samples from forest floor layers (Aol, Aof, Aoh and greensward were collected with 25:25 cm plastic frame. The main soil properties were determined in accordance with the standardized methods in the Laboratory of soil science at the Forest Research Institute - BAS. The IPCC Good Practice Guidance for Land Use, Land Use Change and Forestry was used to estimate the soil organic carbon stock in soil and litter. The results obtained showed that the SOC stock was quite similar among forest land-uses. The conversion of natural beech forests to coniferous plantations in studied region is related with slightly expressed decrease in soil carbon storage. The values of SOC stocks in 0-50 cm soil layer in these sites were 8.5 (±2.1 tones/ha for pine and 11.0 (±1.4 tones/ha for spruce, while under the natural beech forest it was 14.8 (±1.0 tones

  14. Integración de bloques IP en diseños SoC

    OpenAIRE

    Villagarcía Wanza, Horacio A.; Bria, Oscar N.

    2002-01-01

    La metodología de diseño de sistemas SoC basándose en bloques IP (Hard o Soft) presenta diversos retos, desde las cuestiones relativas a la síntesis y validación de cada bloque IP, hasta las características de integración física y verificación funcional del sistema completo. Nos propusimos abordar la temática del diseño de bloques IP basándonos en descripciones de hardware por lenguaje (en particular VHDL) y avanzar en los mecanismos para re-utilizar dichos bloques como parte de distintos sis...

  15. SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

    DEFF Research Database (Denmark)

    Reddy, P.N.G.; Serve, H.; Brandts, C.H.;

    2012-01-01

    tandem duplication (ITD), when localized to the biosynthetic compartment, aberrantly activates STAT5. Here, we show that one of the target genes induced by STAT5 is suppressor of cytokine signaling (SOCS)1 - a surprising finding for a known tumor suppressor. Although SOCS1 expression in murine bone...... marrow severely impaired cytokine-induced colony growth, it failed to inhibit FLT3-ITD-supported colony growth, indicating resistance of FLT3-ITD to SOCS1. In addition, SOCS1 coexpression did not affect FLT3-ITD-mediated signaling or proliferation. Importantly, SOCS1 coexpression inhibited interferon......-αand interferon-γ signaling and protected FLT3-ITD hematopoietic cells from interferon-mediated growth inhibitory effects. In a murine bone marrow transplantation model, the coexpression of SOCS1 and FLT3-ITD significantly shortened the latency of a myeloproliferative disease compared with FLT3-ITD alone (P <.01...

  16. Configuration of the LCD Controller & Driver Analysis Based on ARM & Linux Platform%ARM Linux平台下LCD控制器的配置及驱动分析

    Institute of Scientific and Technical Information of China (English)

    韩金利

    2013-01-01

    The importance of LCD drive in Linux platform is introduced. The Samsung's 32-bit embed-ded microprocessor S3C2440A and LR043JC211 are presented for reference. By analyzing the interface circuit design of LCD display module and S3C2440 processor, this paper makes a detailed description of method and software configuration based on S3C-2440A the LCD controller. The LCD driver in the Linux is analyzed, and a verification method and the environment of experimental results are given as well.%介绍了linux平台下进行LCD驱动开发的重要性,以Samsung公司的32位嵌入式微处理器S3C2440A和LR043JC211为例,结合LCD显示模块与S3C2440处理器的接口电路设计,详细说明了基于S3C2440A处理器的LCD控制器的功能和软件配置方法,对Linux环境下LCD驱动进行分析,并给出了一种实验结果的验证环境与方法。

  17. Dual-arm generalized compliant motion with shared control

    Science.gov (United States)

    Backes, Paul G.

    1993-03-01

    A multiple arm generalized compliant motion robot control system governs dual multi-joint robot arms handling an object with both of the arms in accordance with input parameters governing plural respective behaviors to be exhibited by the robot in respective behavior spaces simultaneously. A move-squeeze decomposition processor computes actual move and squeeze decomposition forces based upon current robot force sensor outputs. A compliant motion processor transforms plural object position perturbations of the plural behaviors from the respective behavior spaces to a common space and computes a relative transformation to a behavior-commanded object position in accordance with the object position perturbations of the plural behaviors. A kinematics processor updates a transformation to a current commanded object position based upon the relative transformation to the behavior-commanded object position. A multiple arm squeeze control processor computes from appropriate squeeze force input parameters and from actual squeeze forces for each of the arms, a squeeze control position perturbation for each of the arms, to provide squeeze control. An inverse kinematics processor computes from the commanded object position transformation and from the squeeze control position perturbation, new robot joint angles, and controls respective joints of the robot arms in accordance with the new robot joint angles.

  18. Dual arm generalized compliant motion with shared control

    Science.gov (United States)

    Backes, Paul G.

    1993-03-01

    A multiple arm generalized compliant motion robot control system governs dual multi-joint robot arms handling an object with both of the arms in accordance with input parameters governing plural respective behaviors to be exhibited by the robot in respective behavior spaces simultaneously. A move-squeeze decomposition processor computes actual move and squeeze decomposition forces based upon current robot force sensor outputs. A compliant motion processor transforms plural object position perturbations of the plural behaviors from the respective behavior spaces to a common space and computes a relative transformation to a behavior-commanded object position in accordance with the object position perturbations of the plural behaviors. A kinematics processor updates a transformation to a current commanded object position based upon the relative transformation to the behavior-commanded object position. A multiple arm squeeze control processor computes from appropriate squeeze force input parameters and from actual squeeze forces for each of the arms, a squeeze control position perturbation for each of the arms, to provide squeeze control. An inverse kinematics processor computes from the commanded object position transformation and from the squeeze control position perturbation, new robot joint angles, and controls respective joints of the robot arms in accordance with the new robot joint angles.

  19. ARM System Developer's Guide Designing and Optimizing System Software

    CERN Document Server

    Sloss, Andrew

    2004-01-01

    Over the last ten years, the ARM architecture has become one of the most pervasive architectures in the world, with more than 2 billion ARM-based processors embedded in products ranging from cell phones to automotive braking systems. A world-wide community of ARM developers in semiconductor and product design companies includes software developers, system designers and hardware engineers. To date no book has directly addressed their need to develop the system and software for an ARM-based system. This text fills that gap. This book provides a comprehensive description of the operation of the ARM core from a developer's perspective with a clear emphasis on software. It demonstrates not only how to write efficient ARM software in C and assembly but also how to optimize code. Example code throughout the book can be integrated into commercial products or used as templates to enable quick creation of productive software. The book covers both the ARM and Thumb instruction sets, covers Intel''s XScale Processors, ou...

  20. LISA Long-Arm Interferometry

    Science.gov (United States)

    Thorpe, James I.

    2009-01-01

    An overview of LISA Long-Arm Interferometry is presented. The contents include: 1) LISA Interferometry; 2) Constellation Design; 3) Telescope Design; 4) Constellation Acquisition; 5) Mechanisms; 6) Optical Bench Design; 7) Phase Measurement Subsystem; 8) Phasemeter Demonstration; 9) Time Delay Interferometry; 10) TDI Limitations; 11) Active Frequency Stabilization; 12) Spacecraft Level Stabilization; 13) Arm-Locking; and 14) Embarassment of Riches.