WorldWideScience

Sample records for argos dss feature

  1. Dose modelling for 'dirty bomb' scenarios - an ARGOS DSS feature under development

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Mikkelsen, Torben; Astrup, Poul;

    The world of today is not only facing the risk of accidents (e.g., in nuclear facilities, as considered in the EURANOS project). Also other types of emergencies, notably involving radiological terrorism, pose a threat. Acts of terror would be most likely to take place in a city, where the greatest...

  2. ARGoS: a modular, multi-engine simulator for heterogeneous swarm robotics

    OpenAIRE

    Pinciroli C; Trianni V; O'Grady R; Pini G; Brutschy A; Brambilla M; Mathews N; Ferrante E; Di Caro G; Ducatelle F

    2011-01-01

    We present ARGoS, a novel open source multi-robot simulator. The main design focus of ARGoS is the real-time simulation of large heterogeneous swarms of robots. Existing robot simulators obtain scalability by imposing limitations on their extensibility and on the accuracy of the robot models. By contrast, in ARGoS we pursue a deeply modular approach that allows the user both to easily add custom features and to allocate computational resources where needed by the experiment. A unique feature ...

  3. Argo Navis

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    (the Ship) a large southern constellation representing the ship Argo of Jason and the Argonauts in Greek mythology whose brightest stars were cataloged by Ptolemy (c. AD 100-175) in the Almagest. It was divided up by the French astronomer Nicolas L de Lacaille (1713-62), who charted the southern sky in 1751-2, into the constellations Carina (the Keel), Vela (the Sails), Puppis (the Poop or Stern)...

  4. Hydrodynamic features of the South Aegean Sea as derived from Argo T/ S and dissolved oxygen profiles in the area

    Science.gov (United States)

    Kassis, Dimitris; Krasakopoulou, Evangelia; Korres, Gerasimos; Petihakis, George; Triantafyllou, George S.

    2016-11-01

    In this work, the hydrodynamic picture of the South Aegean Sea is examined through an analysis of recent measurements in its sub-basins, the Myrtoan and Cretan Sea. Both sub-basins play an important role in the water circulation, exchange, and formation processes that affect the dynamics of the whole Eastern Mediterranean. For the first time, Bio-Argo floats were deployed in the area under the Greek Argo Research Infrastructure coordination. The acquired profiles cover an almost 2-year period (November 2013-July 2015) and are compared with previous Argo profiles and the re-processed time-series data recorded from the E1-M3A POSEIDON observatory operating in the area since 2007. The spatio-temporal distribution of the physical and chemical properties in each sub-basin is examined. Dense water formation events are revealed in the northern part (Myrtoan), while the wider area can be characterized as pre-conditioned. In the Cretan basin, a strong inter-annual variability of the salinity field at intermediate and deep layers is observed that is associated with water exchange from its open boundaries. Furthermore, comparison of the dissolved oxygen (DO) distribution with physical water properties within both the mixed layer, and at greater depths, indicated that relatively high but still under-saturated DO values are more likely to be associated with convection events. Finally, an updated picture of the physical properties and the DO distribution is presented based on the last 5 years of measurements and the recent introduction of Bio-Argo floats with DO sensors in the area.

  5. Animal Tracking ARGOS vs GPS

    Science.gov (United States)

    Robinson, P. W.; Costa, D.; Arnould, J.; Weise, M.; Kuhn, C.; Simmons, S. E.; Villegas, S.; Tremblay, Y.

    2006-12-01

    ARGOS satellite tracking technology has enabled a tremendous increase in our understanding of the movement patterns of a diverse array of marine vertebrates from Sharks to marine mammals. Our current understanding has moved from simple descriptions of large scale migratory patterns to much more sophisticated comparisons of animal movements and behavior relative to oceanic features. Further, animals are increasingly used to carry sensors that can acquire water column temperature and salinity profiles. However, a major limitation of this work is the spatial precision of ARGOS locations. ARGOS provides 7 location qualities that range from 3,2,1,0,A,B,Z and correspond to locations with a precision of 150m to tens of kilometers. Until recently, GPS technology could not be effectively used with marine mammals because they did not spend sufficient time at the surface to allow complete acquisition of satellite information. The recent development of Fastloc technology has allowed the development of GPS tags that can be deployed on marine mammals. Here we compare the location quality and frequency derived from standard ARGOS PTTs to Fastloc GPS locations acquired from 11 northern elephant seals, 5 California and 5 Galapagos sea lions and 1 Cape and 3 Australian fur seals. Our results indicate that GPS technology will greatly enhance our ability to understand the movement patterns of marine vertebrates and the in-situ oceanographic data they collect.

  6. NKS NordDSS - report from workshop on the use of Decision Support Systems

    Energy Technology Data Exchange (ETDEWEB)

    Dyve, J.E. (Norwegian Radiation Protection Authority (Norway))

    2010-03-15

    Nuclear preparedness and response authorities in the Nordic countries are using decision support systems (DSS) as part of their operational capability. A DSS compile, display and analyse data that makes up the current and future radiological state of an emergency. ARGOS and RODOS are the two most common systems in use in the Nordic region. The aim of of the NordDSS workshop was to gather Nordic and international experts on DSS, and share knowledge and experience. The workshop brought together 22 experts for two days in Copenhagen. (author)

  7. NKS NordDSS - report from workshop on the use of Decision Support Systems

    International Nuclear Information System (INIS)

    Nuclear preparedness and response authorities in the Nordic countries are using decision support systems (DSS) as part of their operational capability. A DSS compile, display and analyse data that makes up the current and future radiological state of an emergency. ARGOS and RODOS are the two most common systems in use in the Nordic region. The aim of of the NordDSS workshop was to gather Nordic and international experts on DSS, and share knowledge and experience. The workshop brought together 22 experts for two days in Copenhagen. (author)

  8. DSS 13 microprocessor antenna controller

    Science.gov (United States)

    Gosline, R. M.

    1988-01-01

    A microprocessor-based antenna monitor and control system with multiple CPUs are described. The system was developed as part of the unattended station project for DSS 13 and was enhanced for use by the SETI project. The operational features, hardware, and software designs are described, and a discussion is provided of the major problems encountered.

  9. Hydrodynamic features of the South Aegean Sea as derived from Argo T/S and dissolved oxygen profiles in the area

    Science.gov (United States)

    Kassis, Dimitris; Krasakopoulou, Evangelia; Korres, Gerasimos; Petihakis, George; Triantafyllou, George S.

    2016-09-01

    In this work, the hydrodynamic picture of the South Aegean Sea is examined through an analysis of recent measurements in its sub-basins, the Myrtoan and Cretan Sea. Both sub-basins play an important role in the water circulation, exchange, and formation processes that affect the dynamics of the whole Eastern Mediterranean. For the first time, Bio-Argo floats were deployed in the area under the Greek Argo Research Infrastructure coordination. The acquired profiles cover an almost 2-year period (November 2013-July 2015) and are compared with previous Argo profiles and the re-processed time-series data recorded from the E1-M3A POSEIDON observatory operating in the area since 2007. The spatio-temporal distribution of the physical and chemical properties in each sub-basin is examined. Dense water formation events are revealed in the northern part (Myrtoan), while the wider area can be characterized as pre-conditioned. In the Cretan basin, a strong inter-annual variability of the salinity field at intermediate and deep layers is observed that is associated with water exchange from its open boundaries. Furthermore, comparison of the dissolved oxygen (DO) distribution with physical water properties within both the mixed layer, and at greater depths, indicated that relatively high but still under-saturated DO values are more likely to be associated with convection events. Finally, an updated picture of the physical properties and the DO distribution is presented based on the last 5 years of measurements and the recent introduction of Bio-Argo floats with DO sensors in the area.

  10. The ARGO Project

    Science.gov (United States)

    Kozameh, C. N.

    El proyecto µARGO propone el desarrollo, construcción y operación del Observatorio Espacial de Rayos Gamma, que operará en una órbita terrestre. Este observatorio constará de un telescopio con capacidad de medir simultáneamente dirección de incidencia y polarización de rayos Gamma en dos rangos de energía: 50 KeV - 3 MeV y 10 MeV - 1 GeV. Para ello se usarán detectores de silicio de última generación y microelectrónica adaptada a la configuración. La masa total en órbita del observatorio estará en el orden de los 60 - 100 kg. dependiendo de la geometría adoptada lo que permitirá minimizar costos de desarrollo y construcción, sin perder por ello calidad en su misión científica. ? Desde el punto de vista energético μARGO cubrirá el rango cubierto por COMPTEL y EGRET del CGRO, duplicando como mínimo la resolución angular de ambos con una reducción de peso de dos órdenes de magnitud. En adición, μARGO podr´ medir la polarización incidente de los rayos energéticos. Si bien existen otros dos proyectos en marcha (GLAST y AGILE) para reemplazar EGRET que serán lanzados antes que μARGO, estos proyectos no están diseñados para medir polarización ni tampoco cubren el rango mas bajo de energía arriba mencionado.

  11. ARGO-YBJ Highlights

    CERN Document Server

    Di Sciascio, G

    2010-01-01

    The ARGO-YBJ experiment is a multipurpose detector exploiting the full-coverage approach at very high altitude. The apparatus is in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). In this paper we report the main results in Gamma-Ray Astronomy and Cosmic Ray Physics after about 3 years of operations.

  12. Implementation in ARGOS of ERMIN and AGRICP

    DEFF Research Database (Denmark)

    Jacobsen, L.H.; Andersson, Kasper Grann; Charnock, T.;

    2010-01-01

    . This paper provides a short overview of the background of the two models and describes the features enabled through their implementation in the ARGOS decision support system. The integration allows calculation of both dose rates and doses in particular areas, and can be used to evaluate the effectiveness......The ERMIN model is a new implement developed to enable estimation of the radiological consequences in inhabited areas of accidents in nuclear installations. Similarly, AGRICP is a model developed to enable estimation of the radiological consequences of contamination of agricultural production areas...

  13. Argos: an Automaton-Based Synchronous Language

    OpenAIRE

    Maraninchi, Florence; Rémond, Yann

    2001-01-01

    International audience Argos belongs to the family of synchronous languages, designed for programming reactive systems (Lustre, Esterel, Signal, ...). Argos is a set of operators that allow to combine Boolean Mealy machines, in a compositional way. It takes its origin in Statecharts, but with the Argos operators, one can build only a subset of Statecharts, roughly those that do not make use of multi-level arrows. We explain the main motivations for the definition of Argos, and the main dif...

  14. Puitmaja klaster : intervjuu Argo Sauliga / Argo Saul ; intervjueerinud Kalle Komissarov

    Index Scriptorium Estoniae

    Saul, Argo

    2010-01-01

    Eesti Puitmajaliidu juhatuse esimehe ning Nordic Houses osaniku ja juhatuse esimehe Argo Sauliga arhitektide ja tüüpmaja tootjate võimalikust koostööst Eesti puitmaja klastris, millega Eesti Arhitektide Liit on liitunud. Nordic Houses on norra arhitektide projektide järgi tootnud ja tarninud üle 700 puhkemaja Norrasse

  15. Reval Hotel Lietuva / Argo Vaikla

    Index Scriptorium Estoniae

    Vaikla, Argo, 1966-

    2004-01-01

    Vilniuse hotelli "Lietuva" renoveerimine. Arhitektuurne renoveerimisprojekt: Aare Saks, Nils Palm (SWECO FFNS Arkitekter AB, Rootsi), Rolandas Palekas (UAB Viltekta). Sisekujundus: Katrin ja Argo Vaikla, Liis Lindvere, Peeter Loo (Vaikla Disain AS). Ehitaja: Merko Statyba UAB. Projekt 2002, valmis 2003. I korruse plaan, välisvaade, 4 sisevaadet

  16. Radar RFI at Goldstone DSS 12 and DSS 16

    Science.gov (United States)

    Slobin, S. D.; Peng, T. K.

    1990-01-01

    Radio frequency interference (RFI) from the DSS 14 Goldstone Solar System Radar (GSSR) was investigated at DSS 12 and DSS 16 with the goal of assisting in the choice of the location of future DSN antennas. Total power measurements at both locations were made at the S-band carrier frequency of 2320 MHz. X-band measurements at the carrier frequency of 8495 MHz could not be made. Exciter-chain output spectrum and klystron output spectrum measurements were made at S- and X-bands using a probable worst-case modulation of the radar signal (short pseudorandom number (PN) code length and short pulse length). Based on these measurements, it is estimated that RFI levels in the DSN receiving bands at both sites (above 10-deg elevation) would be below -192 dBm for a 1-Hz bandwidth

  17. Customised DSS and decision conferences

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn; Leleur, Steen

    2009-01-01

    This paper presents and exemplifies a combination of techniques for deriving and modelling decision-maker and/or stakeholder preferences using a decision conference process. The applied techniques are used for the development of customised decision support systems (C-DSS) which can be used...... for appraisals of large transport infrastructure projects. The paper exemplifies how the process at a decision conference can be effectively supported by a DSS customised using appropriate techniques for the specific task in hand. In this respect a conventional cost-benefit analysis (CBA) is combined...

  18. How Incorporating Feedback Mechanisms in a DSS Affects DSS Evaluations

    NARCIS (Netherlands)

    U. Kayande (Ujwal); A. de Bruyn (Arnoud); G.L. Lilien (Gary); A. Rangaswamy (Arvind); G.H. van Bruggen (Gerrit)

    2008-01-01

    textabstractModel-based decision support systems (DSSs) improve performance in many contexts that are datarich, uncertain, and require repetitive decisions. But such DSSs are often not designed to help users understand and internalize the underlying factors driving DSS recommendations. Users then fe

  19. Capstone Renaissance = Simulation + Interaction + DSS.

    Science.gov (United States)

    Jauch, Lawrence R.; And Others

    1989-01-01

    Reviews the development of integrated business policy and strategic management courses, or capstone courses, in business school curricula. A simulation game is described that incorporates the need for computer literacy, decision support systems (DSS), and interaction to effectively meet the needs for a capstone course. (14 references) (LRW)

  20. ARGOS laser system mechanical design

    Science.gov (United States)

    Deysenroth, M.; Honsberg, M.; Gemperlein, H.; Ziegleder, J.; Raab, W.; Rabien, S.; Barl, L.; Gässler, W.; Borelli, J. L.

    2014-07-01

    ARGOS, a multi-star adaptive optics system is designed for the wide-field imager and multi-object spectrograph LUCI on the LBT (Large Binocular Telescope). Based on Rayleigh scattering the laser constellation images 3 artificial stars (at 532 nm) per each of the 2 eyes of the LBT, focused at a height of 12 km (Ground Layer Adaptive Optics). The stars are nominally positioned on a circle 2' in radius, but each star can be moved by up to 0.5' in any direction. For all of these needs are following main subsystems necessary: 1. A laser system with its 3 Lasers (Nd:YAG ~18W each) for delivering strong collimated light as for LGS indispensable. 2. The Launch system to project 3 beams per main mirror as a 40 cm telescope to the sky. 3. The Wave Front Sensor with a dichroic mirror. 4. The dichroic mirror unit to grab and interpret the data. 5. A Calibration Unit to adjust the system independently also during day time. 6. Racks + platforms for the WFS units. 7. Platforms and ladders for a secure access. This paper should mainly demonstrate how the ARGOS Laser System is configured and designed to support all other systems.

  1. Argo packing friction research update

    International Nuclear Information System (INIS)

    This paper focuses on the issue of valve packing friction and its affect on the operability of motor- and air-operated valves (MOVs and AOVs). At this time, most nuclear power plants are required to perform postmaintenance testing following a packing adjustment or replacement. In many cases, the friction generated by the packing does not impact the operability window of a valve. However, to date there has not been a concerted effort to substantiate this claim. To quantify the effects of packing friction, it has become necessary to develop a formula to predict the friction effects accurately. This formula provides a much more accurate method of predicting packing friction than previously used factors based strictly on stem diameter. Over the past 5 years, Argo Packing Company has been developing and testing improved graphite packing systems at research facilities, such as AECL Chalk River and Wyle Laboratories. Much of this testing has centered around reducing and predicting friction that is related to packing. In addition, diagnostic testing for Generic Letter 89-10 MOVs and AOVs has created a significant data base. In July 1992 Argo asked several utilities to provide running load data that could be used to quantify packing friction repeatability and predictability. This technical paper provides the basis to predict packing friction, which will improve calculations for thrust requirements for Generic Leter 89-10 and future AOV programs. In addition, having an accurate packing friction formula will improve packing performance when low running loads are identified that would indicate insufficient sealing force

  2. OBIS - ARGOS Satellite Tracking of Animals

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Various species have been tracked using ARGOS PTT trackers since the early 1990's. These include Emperor, King and Adelie pengiuns, Light-mantled Sooty, Grey-headed...

  3. Using Business Games in Teaching DSS

    Science.gov (United States)

    Ben-Zvi, Tal

    2007-01-01

    In this study a business game is used as a vehicle for implementing decision support systems (DSS). Eighteen companies, consisting of ninety graduating M.B.A. students, participating in a business game were required to develop DSS and to report on the systems developed. Each of the eighteen companies developed a system of their own choosing,…

  4. Multifrequency seismic detectability of seasonal thermoclines assessed from ARGO data

    Science.gov (United States)

    Ker, S.; Le Gonidec, Y.; Marié, L.

    2016-08-01

    Seismic oceanography is a developing research topic where new acoustic methods allow high-resolution teledetection of the thermohaline structure of the ocean. First implementations to study the Ocean Surface Boundary Layer have recently been achieved but remain very challenging due to the weakness and shallowness of such seismic reflectors. In this article, we develop a multifrequency seismic analysis of hydrographic data sets collected in a seasonally stratified midlatitude shelf by ARGO network floats to assess the detectability issue of shallow thermoclines. This analysis, for which sensitivity to the data reduction scheme used by ARGO floats for the transmission of the profiles is discussed, allows characterizing both the depth location and the frequency dependency of the dominant reflective feature of such complex structures. This approach provides the first statistical distribution of the range of variability of the frequency-dependent seismic reflection amplitude of the midlatitude seasonal thermoclines. We introduce a new parameter to quantify the overall capability of a multichannel seismic setup, including the source strength, the fold, and the ambient noise level, to detect shallow thermoclines. Seismic source signals are approximated by Ricker wavelets, providing quantitative guidelines to help in the design of seismic experiments targeting such oceanic reflectors. For shallow midlatitude seasonal thermoclines, we show that the detectability is optimal for seismic peak frequencies between 200 and 400 Hz: this means that airgun and Sparker sources are not well suited and that significant improvements of source devices will be necessary before seismic imaging of OSBL structures can be reliably attempted.

  5. Design of the wavefront sensor unit of ARGOS, the LBT laser guide star system

    CERN Document Server

    Bonaglia, Marco

    2012-01-01

    ARGOS is the laser guide star ground layer adaptive optics system of the LBT. ARGOS is designed to bring a moderate but uniform reduction of the PSF size over a FoV as large as 4x4arcmin, allowing a significative increase of the science throughput of LUCI, the LBT NIR imager and MOS. ARGOS relays on 3 Rayleigh beacons to sense the lower layers of the atmosphere achieving almost 100% sky coverage. The ground layer AO correction is allowed by the 2 adaptive secondaries of the LBT. This PhD thesis first discusses a study based on numerical simulations and aimed to evaluate the performance of ARGOS. This work has been carried out using CAOS and representing in the code most of the features that characterize the system itself: as the laser beacon propagation in the atmosphere, the SH type wavefront sensing, the AO reconstruction and closed loop delays and the atmosphere tip-tilt sensing done using a NGS and a quad-cell type sensor. The results obtained in this study are in agreement and definitively confirm the pe...

  6. Impact study of the Argo array definition in the Mediterranean Sea based on satellite altimetry gridded data

    Science.gov (United States)

    Sanchez-Roman, Antonio; Ruiz, Simón; Pascual, Ananda; Guinehut, Stéphanie; Mourre, Baptiste

    2016-04-01

    the Mediterranean as the "true" field. The choice of the reference depth of Argo profiles impacts the number of valid profiles used to compute DHA and therefore the spatial coverage by the network. Results show that the impact of the reference level in the computation of Argo DH is statistically significant since the standard deviation of the differences between DH computed from Altimetry and Argo data referred to reference depth of 400 dbar and 900 dbar are quite different (4.85 and 5.11 cm, respectively). Therefore, 400 dbar should be taken as reference depth to compute DHA from Argo data in the Mediterranean. On the contrary, similar scores are obtained when shallow floats are not included in the computation (4.85 cm against 4.87 cm). In any case, we must highlight that all the studies show significant correlations (95 %) higher than 0.70 between Altimetry and Argo data with a STD for the differences between both datasets of around 4.90 cm. Furthermore, the sub-basin study shows improved statistics for the eastern sub-basin for DHA referred to 400 dbar while minimum values are obtained for the western sub-basin when computing DHA referred to 900 dbar. On the other hand, results about the OSSEs suggest that maintaining an array of Argo floats of 100×100 km, the variance of the large-scale signal and most of the mesoscale features of SLA fields are recovered. Therefore, the network coverage should be enlarged in the Mediterranean in order to achieve at least this spatial resolution.

  7. Job submission and management system design and implementation for the ARGO grid

    International Nuclear Information System (INIS)

    The ARGO Grid job submission and management system has been developed on the ARGO grid to provide a convenient and efficient way of submitting ARGO jobs to the grid for ARGO physics users. This paper gives details of the system design and implementation with database technique and wrapper technique. The system has been successfully deployed and tested in the ARGO grid with ARGO reconstruction and simulation applications. (authors)

  8. ARGO-YBJ: Status and Highlights

    CERN Document Server

    Di Sciascio, G

    2012-01-01

    The ARGO-YBJ experiment is in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). ARGO-YBJ is facing open problems in Cosmic Ray (CR) physics in different ways. The search for CR sources is carried out by the observation of TeV gamma-ray sources both galactic and extra-galactic. The CR spectrum, composition and anisotropy are measured in a wide energy range (TeV - PeV) thus overlapping for the first time direct measurements. In this paper we summarize the current status of the experiment and describe some of the scientific highlights since 2007.

  9. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  10. 32 CFR 321.14 - DSS implementation policies.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DSS implementation policies. 321.14 Section 321...) PRIVACY PROGRAM DEFENSE SECURITY SERVICE PRIVACY PROGRAM § 321.14 DSS implementation policies. (a) General. The implementation of the Privacy Act of 1974 within DSS is as prescribed by DoD Directive...

  11. The Impact of "Bad" Argo Profiles on Ocean Data Assimilation

    Institute of Scientific and Technical Information of China (English)

    YAN Chang-Xiang; ZHU Jiang

    2010-01-01

    Recent studies have found cold biases in a fraction of Argo profiles (hereinafter referred to as bad Array for Real-time Geostrophic Oceanography (Argo) profiles) due to the pressure drifts during 2003 and 2006. These bad Argo profiles have had an important impact on in situ observation-based global ocean heat content estimates. This study investigated the impact of bad Argo profiles on ocean data assimilation results that were based on observations from diverse ocean observation systems, such as in situ profiles (e.g., Argo, expendable bathythermograph (XBT), and Tropical Atmosphere Ocean (TAO), remote-sensing sea surface temperature products and satellite altimetry between 2004 and 2006. Results from this work show that the upper ocean heat content analysis is vulnerable to bad Argo profiles and demonstrate a cooling trend in the studied period despite the multiple independent data types that were assimilated. When the bad Argo profiles were excluded from the assimilation, the decreased heat content disappeared and a warming occurred. Combination of satellite altimetry and mass variation data from gravity satellite demonstrated an increase, which agrees well with the increased heat content. Additionally, when an additional Argo profile quality control procedure was utilized that simply removed the profiles that presented static unstable water columns, the results were very similar to those obtained when the bad Argo profiles were excluded from the assimilation. This indicates that an ocean data assimilation that uses multiple data sources with improved quality control could be less vulnerable to a major observation system failure, such as a bad Argo event.

  12. Recent highlights from ARGO-YBJ

    Science.gov (United States)

    Di Sciascio, Di; ARGO-YBJ Collaboration

    2016-05-01

    The ARGO-YBJ experiment has been in stable data taking for more than 5 years at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.L, 606 g/cm2 ). With a duty-cycle of about 87% the detector collected more than 5×1011 events in a wide energy range, from few hundreds GeV up to 10 PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this talk we summarize the latest physics results obtained in gamma-ray astronomy and in cosmic ray physics.

  13. ARGOS un reactor a la diagonal

    OpenAIRE

    Barca Salom, Francesc Xavier

    2011-01-01

    El reactor Argos va funcionar des del 16 de gener de 1963 en què va aconseguir l’autorització provisional. Al 1976 el reactor fou aturat per exigències de la nova llei nuclear. Al 1987 es va procedir a la clausura i el 1992 es va enviar l’urani a la Gran Bretanya i es va engegar un procés de descontaminació i desmantellament. Va ser el primer reactor experimental construit majoritàriament a la Junta d'Energia Nuclear.

  14. Experience of the ARGO autonomous vehicle

    Science.gov (United States)

    Bertozzi, Massimo; Broggi, Alberto; Conte, Gianni; Fascioli, Alessandra

    1998-07-01

    This paper presents and discusses the first results obtained by the GOLD (Generic Obstacle and Lane Detection) system as an automatic driver of ARGO. ARGO is a Lancia Thema passenger car equipped with a vision-based system that allows to extract road and environmental information from the acquired scene. By means of stereo vision, obstacles on the road are detected and localized, while the processing of a single monocular image allows to extract the road geometry in front of the vehicle. The generality of the underlying approach allows to detect generic obstacles (without constraints on shape, color, or symmetry) and to detect lane markings even in dark and in strong shadow conditions. The hardware system consists of a PC Pentium 200 Mhz with MMX technology and a frame-grabber board able to acquire 3 b/w images simultaneously; the result of the processing (position of obstacles and geometry of the road) is used to drive an actuator on the steering wheel, while debug information are presented to the user on an on-board monitor and a led-based control panel.

  15. Hotelli Palace**** renoveerimine = Renovation of the hotel Palace**** / Argo Vaikla

    Index Scriptorium Estoniae

    Vaikla, Argo, 1966-

    2015-01-01

    Hotell Palace Tallinnas Vabaduse väljak 3, valminud 2014. Hoone rekonstrueerimisprojekt Reet Valk (AB Reet Valk), sisearhitektid Katrin Vaikla, Argo Vaikla, Mari-Liis Süld, Riin Luuk. 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  16. Cosmic ray physics with ARGO-YBJ

    CERN Document Server

    ,

    2016-01-01

    The ARGO--YBJ experiment has been in stable data taking for more than five years at the Yangbajing cosmic ray observatory (Tibet, P.R. China, 4300 m a.s.l.). The detector collected about $5\\times10^{11}$ events in a wide energy range from few TeVs up to the PeV region. In this work we summarize the latest results in cosmic ray physics particularly focusing on the cosmic ray energy spectrum. The results of the measurement of the all-particle and proton plus helium energy spectra in the energy region between $10^{12} - 10^{16}$ eV are discussed. A precise measurement of the cosmic ray energy spectrum and composition in this energy region allows a better understanding of the origin of the knee and provides a powerful cross-check among different experimental techniques.

  17. Argos: An Optimized Time-Series Photometer

    Indian Academy of Sciences (India)

    Anjum S. Mukadam; R. E. Nather

    2005-06-01

    We designed a prime focus CCD photometer, Argos, optimized for high speed time-series measurements of blue variables (Nather & Mukadam 2004) for the 2.1 m telescope at McDonald Observatory. Lack of any intervening optics between the primary mirror and the CCD makes the instrument highly efficient.We measure an improvement in sensitivity by a factor of nine over the 3-channel PMT photometers used on the same telescope and for the same exposure time. The CCD frame transfer operation triggered by GPS synchronized pulses serves as an electronic shutter for the photometer. This minimizes the dead time between exposures, but more importantly, allows a precise control of the start and duration of the exposure. We expect the uncertainty in our timing to be less than 100 s.

  18. A Participants' DSS for a Management Game with a DSS Generator.

    Science.gov (United States)

    Yeo, Gee Kin; Nah, Fui Hoon

    1992-01-01

    Describes the design of a decision support system (DSS) for a management game called MAGNUS (Management Game for National University of Singapore). Built-in models for performance analysis and decision making are explained; database query and model building are described; and future work is discussed. (11 references) (LRW)

  19. Processed coffee alleviates DSS-induced colitis in mice

    Directory of Open Access Journals (Sweden)

    Bernd L. Fiebich

    2013-05-01

    Full Text Available ABSTRACTBackground: Coffee is one of the most widely consumed beverages in the world and it has been demonstrated that it has important therapeutic activities not only because of its caffeine content but also owing to the presence of other biologically active small molecules such as chlorogenic acid, trigonelline and cyclopentadiones. However, chlorogenic acid is degraded into catechol, pyrogallol and hydroxyhydroquinone, which are thought to induce irritation of the gastric mucosa. To reduce the content of irritant compounds processing methods have been developed prior to roasting the coffee beans.Objectives: The aim of this study was to study the anti-inflammatory and gastro-protective effects of processed coffee (Idee-Kaffee on in LPS-treated human primary monocytes and in a murine model of colon inflammation (IBD model.Results: In this study we have analyzed the effects on inflammatory events in cultured cells and in mice drinking a commercially available processed coffee. The processed coffee inhibited lipopolysaccharide (LPS-induced proinflammatory cytokines such as interleukin (IL-1, tumor necrosis factor (TNF, IL-6 and IL-8, and other inflammatory mediators such as prostaglandin (PGE2 and 8-isoprostane in cultured human primary monocytes. Oral administration of dissolved processed coffee, i.e., in its usual beverage form, improved greatly the adverse macroscopic and histological features of dextran sodium sulfate (DSS-induced colitis in mice in a dose-dependent manner. Processed coffee not only largely prevented DSS-induced colitis but also dramatically suppressed in vivo NF-B and STAT3 activities through inhibition of IB and STAT3 phosphorylation. Furthermore, this solubleFunctional Foods in Health and Disease 2013; 3(5:133-145coffee bean extract reduced the expression of proinflammatory cytokines TNF, IL-11, and IL-6 and the expression of cyclooxygenase (COX-2 in colonic tissues.Conclusions: This work identified

  20. Text-mining-assisted biocuration workflows in Argo.

    Science.gov (United States)

    Rak, Rafal; Batista-Navarro, Riza Theresa; Rowley, Andrew; Carter, Jacob; Ananiadou, Sophia

    2014-01-01

    Biocuration activities have been broadly categorized into the selection of relevant documents, the annotation of biological concepts of interest and identification of interactions between the concepts. Text mining has been shown to have a potential to significantly reduce the effort of biocurators in all the three activities, and various semi-automatic methodologies have been integrated into curation pipelines to support them. We investigate the suitability of Argo, a workbench for building text-mining solutions with the use of a rich graphical user interface, for the process of biocuration. Central to Argo are customizable workflows that users compose by arranging available elementary analytics to form task-specific processing units. A built-in manual annotation editor is the single most used biocuration tool of the workbench, as it allows users to create annotations directly in text, as well as modify or delete annotations created by automatic processing components. Apart from syntactic and semantic analytics, the ever-growing library of components includes several data readers and consumers that support well-established as well as emerging data interchange formats such as XMI, RDF and BioC, which facilitate the interoperability of Argo with other platforms or resources. To validate the suitability of Argo for curation activities, we participated in the BioCreative IV challenge whose purpose was to evaluate Web-based systems addressing user-defined biocuration tasks. Argo proved to have the edge over other systems in terms of flexibility of defining biocuration tasks. As expected, the versatility of the workbench inevitably lengthened the time the curators spent on learning the system before taking on the task, which may have affected the usability of Argo. The participation in the challenge gave us an opportunity to gather valuable feedback and identify areas of improvement, some of which have already been introduced. Database URL: http://argo.nactem.ac.uk.

  1. A statistical method for correcting salinity observations from autonomous profiling floats: An ARGO perspective

    Digital Repository Service at National Institute of Oceanography (India)

    Durand, F.; Reverdin, G.

    The Profiling Autonomous Lagrangian Circulation Explorer (PALACE) float is used to implement the Array for Real-Time Geostrophic Oceanography (ARGO). This study presents a statistical approach to correct salinity measurement errors of an ARGO...

  2. DSS1/Sem1, a multifunctional and intrinsically disordered protein

    DEFF Research Database (Denmark)

    Kragelund, Birthe Brandt; Schenstrøm, Signe Marie; Rebula, Caio A.;

    2016-01-01

    DSS1/Sem1 is a versatile intrinsically disordered protein. Besides being a bona fide subunit of the 26S proteasome, DSS1 associates with other protein complexes, including BRCA2-RPA, involved in homologous recombination; the Csn12-Thp3 complex, involved in RNA splicing; the integrator, involved...... in transcription; and the TREX-2 complex, involved in nuclear export of mRNA and transcription elongation. As a subunit of the proteasome, DSS1 functions both in complex assembly and possibly as a ubiquitin receptor. Here, we summarise structural and functional aspects of DSS1/Sem1 with particular emphasis on its...... multifunctional and disordered properties. We suggest that DSS1/Sem1 can act as a polyanionic adhesive to prevent nonproductive interactions during construction of protein assemblies, uniquely employing different structures when associating with the diverse multisubunit complexes....

  3. ARGO-YBJ data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    Aloisio, A. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy); Branchini, P. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Budano, A. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Catalanotti, S. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy); Creti, P. [Dipartimento di Ingegneria, Universita degli Studi di Lecce and INFN, Lecce (Italy); Galeazzi, F. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Marsella, G. [Dipartimento di Ingegneria, Universita degli Studi di Lecce and INFN, Lecce (Italy); Mastroianni, S. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy)]. E-mail: Stefano.Mastroianni@na.infn.it; Ruggieri, F. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Stanescu, C. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy)

    2006-12-01

    The ARGO-YBJ experiment is reaching its final design configuration. An array of single layer Resistive Plate Counters (RPCs) covering an area of {approx}5800m{sup 2} will collect a huge amount of data. The throughput required from the final detector strongly depends on the trigger rate. The DAQ system must be able to sustain a data transfer rate estimated to be the order of 15MB/s and a high peak of data flow. Data are read out using a typical front-end acquisition chain built around a custom bus. Specialized electronics have been designed and efficient software had to be written to perform this task. Data are then sent to the on-line farm through a switch exploiting gigabit-ethernet protocol. In this paper we will describe the design of the DAQ system, the software which deals with data collection and network sending and the performances. The architecture of the on-line farm is also described together with the monitoring system.

  4. Meso-scale circulation at the intermediate-depth east of Mindanao observed by Argo profiling floats

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The meso-scale circulation at the intermediate depth east of Mindanao is studied using Argo profiling floats observations. The trajectories and the parking-depth velocities of Argo floats show that the intermediate-depth circulation east of Mindanao contains significant meso-scale features that are highly variable both in space and in time. Both cyclonic and anticyclonic eddies at the intermediate depth (1000–2000 m) are indicated by the trajectories east of Mindanao. The mean tangential velocities of these eddies are about 10 cm/s at 2000 m and over 20 cm/s at 1000 m, which indicates that the geostrophic calculation may contain large errors due to the vigorous eddy activity at the reference levels. The analyses also suggest that these eddies might play an important role in mass and vorticity balances of the intermediate-depth circulation east of Mindanao.

  5. Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS in Mice Treated with FR91

    Directory of Open Access Journals (Sweden)

    Valter R. M. Lombardi

    2012-01-01

    Full Text Available One of the main treatments currently used in humans to fight cancer is chemotherapy. A huge number of compounds with antitumor activity are present in nature, and many of their derivatives are produced by microorganisms. However, the search for new drugs still represents a main objective for cancer therapy, due to drug toxicity and resistance to multiple chemotherapeutic drugs. In animal models, a short-time oral administration of dextran sulfate sodium (DSS induces colitis, which exhibits several clinical and histological features similar to ulcerative colitis (UC. However, the pathogenic factors responsible for DSS-induced colitis and the subsequent colon cancer also remain unclear. We investigated the effect of FR91, a standardized lysate of microbial cells belonging to the Bacillus genus which has been previously shown to have significant immunomodulatory effects, against intestinal inflammation. Colitis was induced in mice during 5 weeks by oral administration 2% (DSS. Morphological changes in the colonic mucosa were evaluated by hematoxylin-eosin staining and immunohistochemistry methods. Adenocarcinoma and cryptal cells of the dysplastic epithelium showed cathenin-β, MLH1, APC, and p53 expression, together with increased production of IFN-γ. In our model, the optimal dose response was the 20% FR91 concentration, where no histological alterations or mild DSS-induced lesions were observed. These results indicate that FR91 may act as a chemopreventive agent against inflammation in mice DSS-induced colitis.

  6. Grim19 Attenuates DSS Induced Colitis in an Animal Model.

    Science.gov (United States)

    Kim, Jae-Kyung; Lee, Seung Hoon; Lee, Seon-Young; Kim, Eun-Kyung; Kwon, Jeong-Eun; Seo, Hyeon-Beom; Lee, Han Hee; Lee, Bo-In; Park, Sung-Hwan; Cho, Mi-La

    2016-01-01

    DSS induced colitis is a chronic inflammatory disease characterized by inflammation in the gastrointestinal tract, which destabilizes the gut and induces an uncontrolled immune response. Although DSS induced colitis is generally thought to develop as a result of an abnormally active intestinal immune system, its pathogenesis remains unclear. Gene associated with retinoid interferon induced mortality (Grim) 19 is an endogenous specific inhibitor of STAT3, which regulates the expression of proinflammatory cytokines. In this study, we investigated the influence of GRIM19 in a DSS induced colitis mouse model. We hypothesized that Grim19 would ameliorate DSS induced colitis by altering STAT3 activity and intestinal inflammation. Grim19 ameliorated DSS induced colitis severity and protected intestinal tissue. The expression of STAT3 and proinflammatory cytokines such as IL-1β and TNF-α in colon and lymph nodes was decreased significantly by Grim19. Moreover, DSS induced colitis progression in a Grim19 transgenic mouse line was inhibited in association with a reduction in STAT3 and IL-17 expression. These results suggest that Grim19 attenuates DSS induced colitis by suppressing the excessive inflammatory response mediated by STAT3 activation.

  7. Grim19 Attenuates DSS Induced Colitis in an Animal Model

    Science.gov (United States)

    Kim, Jae-kyung; Lee, Seung Hoon; Lee, Seon-Young; Kim, Eun-Kyung; Kwon, Jeong-Eun; Seo, Hyeon-Beom; Lee, Han Hee; Lee, Bo-In; Park, Sung-Hwan; Cho, Mi-La

    2016-01-01

    DSS induced colitis is a chronic inflammatory disease characterized by inflammation in the gastrointestinal tract, which destabilizes the gut and induces an uncontrolled immune response. Although DSS induced colitis is generally thought to develop as a result of an abnormally active intestinal immune system, its pathogenesis remains unclear. Gene associated with retinoid interferon induced mortality (Grim) 19 is an endogenous specific inhibitor of STAT3, which regulates the expression of proinflammatory cytokines. In this study, we investigated the influence of GRIM19 in a DSS induced colitis mouse model. We hypothesized that Grim19 would ameliorate DSS induced colitis by altering STAT3 activity and intestinal inflammation. Grim19 ameliorated DSS induced colitis severity and protected intestinal tissue. The expression of STAT3 and proinflammatory cytokines such as IL-1β and TNF-α in colon and lymph nodes was decreased significantly by Grim19. Moreover, DSS induced colitis progression in a Grim19 transgenic mouse line was inhibited in association with a reduction in STAT3 and IL-17 expression. These results suggest that Grim19 attenuates DSS induced colitis by suppressing the excessive inflammatory response mediated by STAT3 activation. PMID:27258062

  8. Implementing a decision support system (DSS in e-business

    Directory of Open Access Journals (Sweden)

    Alexandra Ruiz G.

    2010-05-01

    Full Text Available Decision support systems (DSS and e-business (EB have emerged as separate areas. However, currently, and for some years now, DSS and EB have become merged to provide customers with greater benefits and added value. There are different types of DSS and different categories and business models for EB; one area’s applicability to the other thus expands the possible combi- nations which can arise from such different categories. Some representative examples would include auction sites which, through applying intelligent agents, can learn about which products to offer or when and where to sell them; DSS allow a company’s in- formation avilable in web portals for customers and employees to be accessed in a controlled way and decisions thus made; vir- tual stores may be positively affected by data mining and data warehousing being applied; complex algorithms could be used in customer relationship management for predicting and analysing “what would happen if” to identify revenue opportunities in com- petitive markets; and a wide range of other applications where imagination is the limit. Research into DSS / BE must be ongoing due to the constant emergence of new business models and DSS subsystems. Applications can be varied and provide bi-directio- nal support for each one. New interaction mechanisms and efforts to satisfy customers are also the focus of inspiration for new applications for DSS systems in EB.

  9. DSS and GIS in Knowledge Transformation Process

    Directory of Open Access Journals (Sweden)

    Klimešová Dana

    2009-06-01

    Full Text Available Knowledge is an important resource for successful decision-making process in the whole society today. The special procedures of control and management of knowledge therefore have to be used. In the area of knowledge management and knowledge engineering basic terms of these disciplines are data, information, knowledge and knowledge transformation. The knowledge can be defined as a dynamic human process of justifying personal beliefs. Knowledge is a product of successful decision-making process. Knowledge transformation is a spiralling process of interactions between explicit and tacit knowledge that leads to the new knowledge. Nonaka and all show, that the combination of these two categories makes possible to conceptualise four conversion steps: Socialisation, Externalisation, Combination and Internalisation (SECI model. Another model of knowledge creation is the Knowledge Transformation Continuum (BCI Knowledge Group that begins with the articulation of a specific instruction representing the best way that a specific task, or series of tasks, should be performed. Knowledge modelling and knowledge representation is an important field of research also in Computer Science and Artificial Intelligence. The definition of knowledge in Artificial Intelligence is a noticeable different, because Artificial Intelligence is typically dealing with formalized knowledge (e.g. ontology. The development of knowledge-based systems was seen as a process of transferring human knowledge to an implemented knowledge base. Decision Support Systems (DSS, Geographical Information Systems (GIS and Operations Research/Management Science (OR/MS modelling process support decision-making process, therefore they also produce a new knowledge. A Decision Support Systems are an interactive computer-based systems helping decision makers complete decision process. Geographic Information Systems provide essential marketing and customer intelligence solutions that lead to better

  10. Environmental Resources Analysis System, A Prototype DSS

    Science.gov (United States)

    Flug, M.; Campbell, S.G.; Bizier, P.; DeBarry, P.

    2003-01-01

    Since the 1960's, an increase in the public's environmental ethics, federal species preservation, water quality protection, and interest in free flowing rivers have evolved to the current concern for stewardship and conservation of natural resources. This heightened environmental awareness creates an appetite for data, models, information management, and systematic analysis of multiple scientific disciplines. A good example of this information and analysis need resides in the Green and Yampa Rivers, tributary to the Upper Colorado River. These rivers are home to endangered native fish species including the pikeminnow and razorback sucker. Two dams, Fontenelle and Flaming Gorge, impound the Green River headwaters. The respective reservoirs store water supplies as well as generate hydropower. Conversely, the Yampa River is considered unregulated and encompasses most of Dinosaur National Monument. Recreation is highly regarded on both rivers including fishing, whitewater rafting, and aesthetic values. Vast areas of irrigated agriculture, forestry, and mineral extraction also surround these rivers. To address this information need, we developed a prototype Environmental Resources Analysis System (ERAS) spreadsheet-based decision support system (DSS). ERAS provides access to historic data sets, scientific information, statistical analysis, model outputs, and comparative methods all in a familiar and user-friendly format. This research project demonstrates a simplified decision support system for use by a diverse mix of resource managers, special interest groups, and individuals concerned about the sustainability of the Green and Yampa River ecosystem.

  11. PCI DSS a practical guide to implementing and maintaining compliance

    CERN Document Server

    Wright, Steve

    2011-01-01

    This newly revised, practical guide, gives you a step by step guide to achieving Payment Card Industry Data Security Standard (PCI DSS) compliance - showing you how to create, design and build a PCI compliance framework.

  12. Implementation of SLODAR atmospheric turbulence profiling to the ARGOS system

    Science.gov (United States)

    Mazzoni, Tommaso; Busoni, Lorenzo; Bonaglia, Marco; Esposito, Simone

    2014-08-01

    ARGOS is the Ground Layer Adaptive Optics system of the Large Binocular Telescope, it uses three Laser Guide Stars at 12 km altitude, generated by Rayleigh backscattered light of pulsed Nd:YAG lasers at 532nm. The wavefront distortion in the Ground Layer is measured by three Shack-Hartmann WFS, sampling with 15×15 subaperture the three LGS arranged on a single CCD with 8×8px per square subaperture. The SLOpe Detection And Ranging (SLODAR) is a method used to measure the turbulence profiles. Cross correlation of wavefronts gradient from multiple stars is used to estimate the relative strengths of turbulent layers at different altitudes. In the ARGOS case the LGS are arranged on a triangle inscribed in a 2 arcmin radius circle, so we expect an effective slopes correlation up to 5km altitude. We present here the results of a study aimed to implement the SLODAR method on ARGOS performed with the idl-based simulation code used to characterize the ARGOS performance. Simulation implements the atmospheric turbulence on different layers with variable strength, altitude and wind speed. The algorithm performance are evaluated comparing the input turbulence with the cross-correlation of the SH slopes acquired in open loop.

  13. Validation of argo data in the Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Pankajakshan, T.; Muraleedharan, P.M.; Gopalakrishna, V.V.; Reddy, G.V.; Ratnakaran, L.; Revichandran, C.; Murty, V.S.N.

    in the dimension of the conductivity cell due to fouling. Sensor manufacturers have improved the anti-fouling measures with biocide rings and anti-fouling paint (Tri- Butyl Tin Oxide, TBTO). However, since the Argo floats remain in the waters for years together...

  14. Characterizing Ocean Turbulence from Argo, Acoustic Doppler, and Simulation Data

    Science.gov (United States)

    McCaffrey, Katherine

    Turbulence is inherently chaotic and unsteady, so observing it and modeling it are no easy tasks. The ocean's sheer size makes it even more difficult to observe, and its unpredictable and ever-changing forcings introduce additional complexities. Turbulence in the oceans ranges from basin scale to the scale of the molecular viscosity. The method of energy transfer between scales is, however, an area of active research, so observations of the ocean at all scales are crucial to understanding the basic dynamics of its motions. In this collection of work, I use a variety of datasets to characterize a wide range of scales of turbulence, including observations from multiple instruments and from models with different governing equations. I analyzed the largest scales of the turbulent range using the global salinity data of the Argo profiling float network. Taking advantage of the scattered and discontinuous nature of this dataset, the second-order structure function was calculated down to 2000m depth, and shown to be useful for predicting spectral slopes. Results showed structure function slopes of 2/3 at small scales, and 0 at large scales, which corresponds with spectral slopes of -5/3 at small scales, and -1 at large scales. Using acoustic Doppler velocity measurements, I characterized the meter- to kilometer-scale turbulence at a potential tidal energy site in the Puget Sound, WA. Acoustic Doppler current profiler (ADCP) and acoustic Doppler velocimeter (ADV) observations provided the data for an analysis that includes coherence, anisotropy, and intermittency. In order to more simply describe these features, a parameterization was done with four turbulence metrics, and the anisotropy magnitude, introduced here, was shown to most closely capture the coherent events. Then, using both the NREL TurbSim stochastic turbulence generator and the NCAR large-eddy simulation (LES) model, I calculated turbulence statistics to validate the accuracy of these methods in reproducing

  15. Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction[OPEN

    Science.gov (United States)

    Shi, Jinrui; Wang, Hongyu; Habben, Jeffrey E.

    2016-01-01

    The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize. PMID:27268962

  16. Validation of salinity data from ARGO floats: Comparison between the older ARGO floats and that of later deployments

    Digital Repository Service at National Institute of Oceanography (India)

    Youn, Y.-H.; Lee, H.; Chang, Y.-S.; Pankajakshan, T.

    time different of less than 100 km are considered for the match-up data sets. For analysis of the salinity drift under the stable water mass, observations of the floats from deepest water masses have been used. From the cross-check of ARGO floats...

  17. Drift in salinity data from Argo profiling floats in the Sea of Japan

    Digital Repository Service at National Institute of Oceanography (India)

    Pankajakshan, T.; Bajish, C.C.; Behera, S.; Gopalakrishna, V.V.

    for constructive sug- gestionsthat helpedtoimprovethequalityof thepaper. REFERENCES Argo, 2010: Report of 11th Argo Data Management Meeting, version1.2.,124pp.[Availableonlineathttp://www.argodatamgt. org/Data-Mgt-Team/Meetings-and-reports.] Bryden, L. H., E. L. Mc... inopenoceanregions, in additiontoconfinedbasins suchas SOJ, SALD was applied successfully todetect salinity error in Argo data from the subtropical North Pacific (SNP). 1. Introduction Salinity plays a major role in ocean circulation to af- fect regional and global...

  18. Physics Results from the Argo-YBJ Experiment

    CERN Document Server

    Di Sciascio, G

    2008-01-01

    The ARGO-YBJ experiment has been in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l.). In this paper we report a few selected results in Gamma-Ray Astronomy (Crab Nebula and Mrk421 observations, search for high energy tails of GRBs) and Cosmic Ray Physics (Moon and Sun shadow observations, proton-air cross section and antiproton/proton preliminary measurements).

  19. Gamma-Ray Astronomy with ARGO-YBJ

    CERN Document Server

    Di Sciascio, G

    2011-01-01

    ARGO-YBJ is a full coverage air shower array located at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm^2) recording data with a duty cycle $\\geq$85% and an energy threshold of a few hundred GeV. In this paper the latest results in Gamma-Ray Astronomy are summarized.

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-04-01 for the Global Argo Data Repository, date ranged from 2005-10-23 to 2010-04-07 (NODC Accession 0062992)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-05-18 for the Global Argo Data Repository, date ranged from 2001-11-28 to 2003-05-24 (NODC Accession 0001037)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-04-30 for the Global Argo Data Repository, date ranged from 2002-03-08 to 2006-05-06 (NODC Accession 0002664)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-11-06 for the Global Argo Data Repository, date ranged from 2001-10-13 to 2005-11-12 (NODC Accession 0002455)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-07-16 for the Global Argo Data Repository, date ranged from 2002-03-01 2009-07-22 (NODC Accession 0056186)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-09-07 for the Global Argo Data Repository, date ranged from 2003-04-28 to 2003-09-13 (NODC Accession 0001166)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of November 2006 for the Global Argo Data Repository, 1996-01-05 to 2006-12-01 (NODC Accession 0011212)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-12-10 for the Global Argo Data Repository, date ranged from 2002-12-08 to 2006-12-16 (NODC Accession 0011574)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-09-03 for the Global Argo Data Repository, date ranged from 1998-05-25 to 2006-09-09 (NODC Accession 0002834)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-06-08 for the Global Argo Data Repository, date ranged from 2003-05-26 to 2003-06-14 (NODC Accession 0001054)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-06-19 for the Global Argo Data Repository, date ranged from 2000-06-18 to 2005-06-25 (NODC Accession 0002257)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-03-12 for the Global Argo Data Repository, date ranged from 1998-12-08 to 2009-03-18 (NODC Accession 0002061)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-03-04 for the Global Argo Data Repository, date ranged from 2001-09-30 to 2007-03-10 (NODC Accession 0013875)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  13. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of January 2007 for the Global Argo Data Repository, 1996-01-05 to 2007-01-31 (NODC Accession 0013024)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-07-27 for the Global Argo Data Repository, date ranged from 2001-10-27 to 2003-08-02 (NODC Accession 0001117)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  15. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-08-20 for the Global Argo Data Repository, date ranged from 2001-09-30 to 2009-08-26 (NODC Accession 0057201)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-12-03 for the Global Argo Data Repository, date ranged from 1999-10-25 to 2006-12-09 (NODC Accession 0011263)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of June 2007 for the Global Argo Data Repository, 1996-01-05 to 2007-07-01 (NODC Accession 0020937)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  18. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-02-11 for the Global Argo Data Repository, date ranged from 2002-10-29 to 2007-02-17 (NODC Accession 0013200)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-12-24 for the Global Argo Data Repository, date ranged from 2002-02-15 to 2009-12-30 (NODC Accession 0060860)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-03-26 for the Global Argo Data Repository, date ranged from 1999-10-02 to 2009-04-01 (NODC Accession 0052543)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-10-14 for the Global Argo Data Repository, date ranged from 1995-09-07 to 2007-10-20 (NODC Accession 0035978)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-06-01 for the Global Argo Data Repository, date ranged from 2001-10-18 to 2003-06-07 (NODC Accession 0001051)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-12-17 for the Global Argo Data Repository, date ranged from 2002-02-05 to 2009-12-23 (NODC Accession 0060676)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2008-01-06 for the Global Argo Data Repository, date ranged from 2002-12-13 to 2008-01-12 (NODC Accession 0038182)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-10-19 for the Global Argo Data Repository, date ranged from 2003-06-08 to 2003-10-25 (NODC Accession 0001210)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-05-20 for the Global Argo Data Repository, date ranged from 2003-07-29 to 2007-05-26 (NODC Accession 0019205)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of October 2003 for the Global Argo Data Repository, 1996-01-05 to 2003-10-31 (NODC Accession 0001217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-07-08 for the Global Argo Data Repository, date ranged from 2002-03-30 to 2007-07-14 (NODC Accession 0029182)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-07-02 for the Global Argo Data Repository, date ranged from 2001-07-30 to 2006-07-08 (NODC Accession 0002745)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-01-09 for the Global Argo Data Repository, 2000-03-01 to 2005-01-15 (NODC Accession 0001981)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of April 2006 for the Global Argo Data Repository, 1996-01-05 to 2006-04-30 (NODC Accession 0002655)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-07-08 for the Global Argo Data Repository, date ranged from 2005-01-19 to 2010-07-14 (NODC Accession 0065728)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  13. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-11-19 for the Global Argo Data Repository, date ranged from 2001-01-21 to 2006-11-25 (NODC Accession 0011021)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2008-05-29 for the Global Argo Data Repository, date ranged from 2006-03-01 to 2008-06-04 (NODC Accession 0042701)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  15. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of June 2005 for the Global Argo Data Repository, 1996-01-05 to 2005-06-30 (NODC Accession 0002261)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-02-13 for the Global Argo Data Repository, 2001-04-10 to 2005-02-19 (NODC Accession 0002035)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-10-29 for the Global Argo Data Repository, date ranged from 2001-09-21 to 2009-11-04 (NODC Accession 0059252)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  18. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-03-05 for the Global Argo Data Repository, date ranged from 2002-04-02 to 2006-03-11 (NODC Accession 0002598)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-04-30 for the Global Argo Data Repository, date ranged from 2004-03-06 to 2009-05-06 (NODC Accession 0053667)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-01-08 for the Global Argo Data Repository, date ranged from 2001-06-14 to 2006-01-14 (NODC Accession 0002499)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of May 2007 for the Global Argo Data Repository, 1996-01-05 to 2007-06-01 (NODC Accession 0019350)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-02-18 for the Global Argo Data Repository, date ranged from 2001-09-30 to 2010-02-24 (NODC Accession 0062336)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-05-06 for the Global Argo Data Repository, date ranged from 2001-01-21 to 2010-05-12 (NODC Accession 0064275)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-04-23 for the Global Argo Data Repository, date ranged from 2001-11-07 to 2009-04-29 (NODC Accession 0053406)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-02-19 for the Global Argo Data Repository, date ranged from 1999-07-16 to 2009-02-25 (NODC Accession 0051511)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of February 2007 for the Global Argo Data Repository, 1996-01-05 to 2007-02-28 (NODC Accession 0013628)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-10-05 for the Global Argo Data Repository, date ranged from 2001-10-13 to 2003-10-11 (NODC Accession 0001198)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-01-14 for the Global Argo Data Repository, date ranged from 2003-02-20 to 2010-01-20 (NODC Accession 0061422)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-03-04 for the Global Argo Data Repository, date ranged from 2002-10-05 to 2010-03-10 (NODC Accession 0062620)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of October 2007 for the Global Argo Data Repository, 1995-09-07 to 2007-10-31 (NODC Accession 0036822)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-02-26 for the Global Argo Data Repository, date ranged from 2001-12-12 to 2006-03-04 (NODC Accession 0002591)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-09-12 for the Global Argo Data Repository, date ranged from 2004-01-12 to 2004-09-18 (NODC Accession 0001719)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  13. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-06-05 for the Global Argo Data Repository, date ranged from 2006-10-08 to 2008-06-11 (NODC Accession 0042829)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-04-08 for the Global Argo Data Repository, date ranged from 2005-02-25 to 2007-04-14 (NODC Accession 0014769)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  15. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-08-13 for the Global Argo Data Repository, date ranged from 2002-03-12 to 2009-08-19 (NODC Accession 0057012)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-04-20 for the Global Argo Data Repository, date ranged from 2003-03-10 to 2003-04-26 (NODC Accession 0001001)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-07-18 for the Global Argo Data Repository, date ranged from 2003-09-26 to 2004-07-24 (NODC Accession 0001640)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  18. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-11-20 for the Global Argo Data Repository, date ranged from 2000-02-01 to 2008-11-26 (NODC Accession 0048970)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR as the long-term archive for the International Global Argo Project...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2008-02-24 for the Global Argo Data Repository, date ranged from 1979-05-15 to 2008-03-01 (NODC Accession 0039348)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-05-02 for the Global Argo Data Repository, date ranged from 2000-11-22 to 2004-05-08 (NODC Accession 0001453)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of February 2005 for the Global Argo Data Repository, 1996-01-05 to 2005-02-28 (NODC Accession 0002048)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-04-16 for the Global Argo Data Repository, date ranged from 2004-07-07 to 2009-04-22 (NODC Accession 0053405)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008- 10-16 for the Global Argo Data Repository, date ranged from 1998-05-22 to 2008-10-22 (NODC Accession 0046744)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-01-07 for the Global Argo Data Repository, date ranged from 2003-09-15 to 2010-01-13 (NODC Accession 0061249)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-08-13 for the Global Argo Data Repository, date ranged from 2000-10-31 to 2006-08-19 (NODC Accession 0002802)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-11-21 for the Global Argo Data Repository, date ranged from 2002-08-30 to 2004-11-27 (NODC Accession 0001911)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-11-11 for the Global Argo Data Repository, date ranged from 2002-01-11 to 2007-11-17 (NODC Accession 0036655)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-05-28 for the Global Argo Data Repository, date ranged from 2002-02-05 to 2009-06-02 (NODC Accession 0054265)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-12-31 for the Global Argo Data Repository, date ranged from 2006-03-28 to 2010-01-06 (NODC Accession 0061041)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  10. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-07-10 for the Global Argo Data Repository, date ranged from 2007-12-18 to 2008-07-17 (NODC Accession 0043460)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-04-09 for the Global Argo Data Repository, date ranged from 1998-02-23 to 2006-04-15 (NODC Accession 0002633)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-12-14 for the Global Argo Data Repository, date ranged from 2002-05-12 to 2003-12-20 (NODC Accession 0001272)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  13. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-01-29 for the Global Argo Data Repository, date ranged from 2001-06-03 to 2006-01-31 (NODC Accession 0002527)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-06-18 for the Global Argo Data Repository, date ranged from 2000-04-04 to 2006-06-24 (NODC Accession 0002726)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  15. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-02-05 for the Global Argo Data Repository, date ranged from 2003-10-22 to 2006-02-11 (NODC Accession 0002572)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-10-26 for the Global Argo Data Repository, date ranged from 2003-03-12 to 2003-11-01 (NODC Accession 0001216)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-07-13 for the Global Argo Data Repository, date ranged from 2002-02-17 to 2003-07-19 (NODC Accession 0001103)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  18. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-11-25 for the Global Argo Data Repository, date ranged from 2000-05-10 to 2007-12-01 (NODC Accession 0036984)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-05-13 for the Global Argo Data Repository, date ranged from 2001-01-21 to 2010-05-19 (NODC Accession 0064383)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-10-15 for the Global Argo Data Repository, date ranged from 2006-03-26 to 2006-10-21 (NODC Accession 0010542)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-04-04 for the Global Argo Data Repository, date ranged from 2000-11-22 to 2004-04-10 (NODC Accession 0001422)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-10-02 for the Global Argo Data Repository, date ranged from 2000-12-08 to 2005-10-08 (NODC Accession 0002398)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-06-10 for the Global Argo Data Repository, date ranged from 2004-06-08 to 2010-06-16 (NODC Accession 0065228)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-03-28 for the Global Argo Data Repository, date ranged from 2004-02-29 to 2004-04-03 (NODC Accession 0001411)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  5. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-10-02 for the Global Argo Data Repository, date ranged from 2002-01-19 to 2008-10-08 (NODC Accession 0046221)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  6. Dextran sulfate sodium (DSS)-induced colitis in mice.

    Science.gov (United States)

    Chassaing, Benoit; Aitken, Jesse D; Malleshappa, Madhu; Vijay-Kumar, Matam

    2014-02-04

    Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed. This protocol describes the DSS-induced colitis model, focusing on details and factors that could affect DSS-induced pathology.

  7. DSS-13 S-/X-band microwave feed system

    Science.gov (United States)

    Manshadi, F.

    1994-05-01

    The configuration, detail design, and performance of the dual S-/X-band microwave feed system for the new DSN beam-waveguide antenna, Deep Space Station (DSS) 13, are reported. By using existing spare components, reducing fabrication cost of new components by simplifying their design, and using new fabrication techniques and material, this DSS-13 feed system was implemented successfully with a small budget and a very tight schedule. Measured noise temperature gains of the feed system are 17.5 K for S-band (2200-2300 MHz) and 24.0 K for X-band (8200-8600 MHz), which agree very closely with the predicted performance.

  8. 会计DSS: 决策支持系统在会计学中的应用%Accounting DSS: an Application of DSS to Accounting

    Institute of Scientific and Technical Information of China (English)

    戴悦; 岳超源

    1999-01-01

    探讨了将决策支持系统运用于会计学的问题.分析并提供了会计DSS的基本框架及组成,并以实例展示了会计DSS是如何支持决策的,可作为企业运用DSS 进行会计决策之借鉴.

  9. AOM/DSS Model of Colitis-Associated Cancer.

    Science.gov (United States)

    Parang, Bobak; Barrett, Caitlyn W; Williams, Christopher S

    2016-01-01

    Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.

  10. A DSS for capacity planning of aircraft maintenance personnel

    NARCIS (Netherlands)

    M.C. Dijkstra (Matthijs); L.G. Kroon (Leo); J.A.E.E. van Nunen (Jo); M. Salomon (Marc)

    1991-01-01

    textabstractIn this paper we describe a Decision Support System (DSS) that has been developed for the aircraft maintenance department of the Dutch national airline company at the main airport in the Netherlands. The aircraft maintenance department is responsible for carrying out the regular short in

  11. Decision models for cash-flow DSS (part 1

    Directory of Open Access Journals (Sweden)

    Razvan PETRUSEL

    2006-01-01

    Full Text Available The goal of this paper is to present some of the work conducted in order to create a cash-flow DSS that aims to improve the financial decisions of Romanian small and medium enterprise managers. In order to create the desired DSS two major stages were followed: the construction of models for various financial decisions and the implementation of those models within the knowledge base of the DSS. The present paper covers the first stage while the second stage will be presented in the next article. For a better understanding, the paper is divided into three parts: theoretical considerations, practical application of theory and conclusions. The theoretical part builds up on basic definitions and previous decision theory research, and, taking into consideration different modeling methodologies, establishes the necessary steps and tools that will be used in the second part. The second part establishes the decisional situations that will be modeled, briefly describes each of them and shows the models devised according to particularities of small and medium enterprises. The goal of this part is to create a model (variables, relations between them, etc that is suited for implementation in a cash-flow DSS. In the final part some conclusions are stated and the future research direction is established.

  12. 32 CFR 321.8 - DSS review of request for amendment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DSS review of request for amendment. 321.8... (CONTINUED) PRIVACY PROGRAM DEFENSE SECURITY SERVICE PRIVACY PROGRAM § 321.8 DSS review of request for... correspondence. (b) DSS determination to approve or deny. Determination to approve or deny and request to amend...

  13. Analyses of altimetry errors using Argo and GRACE data

    Science.gov (United States)

    Legeais, Jean-François; Prandi, Pierre; Guinehut, Stéphanie

    2016-05-01

    This study presents the evaluation of the performances of satellite altimeter missions by comparing the altimeter sea surface heights with in situ dynamic heights derived from vertical temperature and salinity profiles measured by Argo floats. The two objectives of this approach are the detection of altimeter drift and the estimation of the impact of new altimeter standards that requires an independent reference. This external assessment method contributes to altimeter calibration-validation analyses that cover a wide range of activities. Among them, several examples are given to illustrate the usefulness of this approach, separating the analyses of the long-term evolution of the mean sea level and its variability, at global and regional scales and results obtained via relative and absolute comparisons. The latter requires the use of the ocean mass contribution to the sea level derived from Gravity Recovery and Climate Experiment (GRACE) measurements. Our analyses cover the estimation of the global mean sea level trend, the validation of multi-missions altimeter products as well as the assessment of orbit solutions.Even if this approach contributes to the altimeter quality assessment, the differences between two versions of altimeter standards are getting smaller and smaller and it is thus more difficult to detect their impact. It is therefore essential to characterize the errors of the method, which is illustrated with the results of sensitivity analyses to different parameters. This includes the format of the altimeter data, the method of collocation, the temporal reference period and the processing of the ocean mass solutions from GRACE. We also assess the impact of the temporal and spatial sampling of Argo floats, the choice of the reference depth of the in situ profiles and the importance of the deep steric contribution. These analyses provide an estimation of the robustness of the method and the characterization of associated errors. The results also allow us

  14. Lactobacillus crispatus M206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

    Institute of Scientific and Technical Information of China (English)

    Fu-Xi Zhou; Lu Chen; Xiao-Wei Liu; Chun-Hui Ouyang; Xiao-Ping Wu; Xue-Hong Wang; Chun-Lian Wang

    2012-01-01

    AIM:To investigate the role of Lactobacillus crispatus (L.crispatus) strain China Center for Type Culture Collection (CCTCC) M206119 in intestinal inflammation.METHODS:Forty 8-wk-old Balb/c mice (20 ± 2 g)were divided into four groups of 10 mice each.Three groups that had received dextran sulfate sodium (DSS)were administered normal saline,sulfasalazine or CCTCC M206119 strain,and the fourth group received none of these.We assessed the severity of colitis using a disease activity index,measured the colon length and weight,collected stools and mesenteric lymph nodes for bacterial microflora analysis.One centimeter of the proximal colon,middle colon and distal colon were collected and fixed in 10% buffered formalin,dehydrated in ethanol,and embedded in paraffin.Interleukin (IL)-1β,IL-6 and tumor necrosis factor (TNF)-α expression was detected using reverse transcription polymerase chain reaction.Protective factors zonula occludens (ZO)-1 and β-defensin 2 were detected by immunoblotting.The features of CCTCC M206119 strain were identified based on morphology,biochemical profile,and 16S RNA sequencing.RESULTS:DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease,with greater weight loss,diarrhea,fecal bleeding,and shortened colon length.In addition,the CCTCC-M206119-treated group had comparatively higher histological scores and more neutrophil infiltration than the controls.Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment.An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells.Intestinal proinflammatory or anti-inflammatory cytokine responses were evaluated.Proinflammatory colonic cytokine (IL-1β,IL-6and TNF-α) levels were clearly increased in CCTCC-M206119-treated animals,whereas anti-inflammatory colonic cytokine (IL-10) level was lowered compared with

  15. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis.

    Science.gov (United States)

    Jang, Jong-Chan; Lee, Kang Min; Ko, Seong-Gyu

    2016-01-01

    We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis. Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days. Oral administration of AAK extract (500 mg/kg/day) significantly alleviated DSS-induced symptoms such as anorexia, weight loss, events of diarrhea or bloody stools, and colon shortening. Histological damage was also ameliorated, as evidenced by the architectural preservation and suppression of inflammatory cell infiltration in colonic samples. Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins. In the isolated serum, IgE levels were downregulated. Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis.

  16. A method to manage the model base in DSS

    Institute of Scientific and Technical Information of China (English)

    孙成双; 李桂君

    2004-01-01

    How to manage and use models in DSS is a most important subject. Generally, it costs a lot of money and time to develop the model base management system in the development of DSS and most are simple in function or cannot be used efficiently in practice. It is a very effective, applicable, and economical choice to make use of the interfaces of professional computer software to develop a model base management system. This paper presents the method of using MATLAB, a well-known statistics software, as the development platform of a model base management system. The main functional framework of a MATLAB-based model base managementsystem is discussed. Finally, in this paper, its feasible application is illustrated in the field of construction projects.

  17. Application of Argo-derived background diapycnal mixing in HYCOM

    Science.gov (United States)

    Deng, Zengan; Yu, Ting

    2014-09-01

    Internal wave-induced background diapycnal mixing (DM) in the upper 2000 m of the global ocean, which primarily depends on the local inertial frequency, is calculated based on Argo observations using the newly published Thermodynamic Equation of Seawater-2010 (IOC, SCOR and IAPSO, 2010). This spatially dependent background DM agrees well with previous theoretical and observational mixing estimates. More importantly, the DM data are gridded, which renders the data suitable for modeling applications. The implementation of these data in the HYbrid Coordinate Ocean Model (HYCOM) demonstrates the potential for their application in numerical ocean models. Three numerical experiments that are specifically designed with different DM settings reveal that the meridional overturning circulation (MOC), temperature and salinity in the Atlantic change substantially when the constant background DM is replaced with Argo-derived mixing. Tropical and high-latitude regions that are considered important for global climate are identified as the areas that are most sensitive to the magnitude of the background DM. Compared with constant background DM, the enhanced mid-latitude DM most likely contributes substantially to the MOC transport. Thus, although room remains for improvement, the spatially varying DM derived in the present study may facilitate global circulation and climate modeling.

  18. Integrated data-driven DSS in a laboratory environment

    OpenAIRE

    Hargrave, Brian L.

    2008-01-01

    Decision support technologies have remained individualistic as primarily stand alone platforms. The ability to access and integrate a wide range of such technologies in an Integrated Decision Technology Environment (IDTE) can potentially increase a user's ability to create more complex decision support projects. A well designed IDTE will allow users to identify, learn about, access, execute and integrate disparate decision technologies. Data-Driven DSS provide decision-makers with th...

  19. Negative regulation of DSS-induced experimental colitis by PILRα.

    Science.gov (United States)

    Kishida, Kazuki; Kohyama, Masako; Kurashima, Yosuke; Kogure, Yuta; Wang, Jing; Hirayasu, Kouyuki; Suenaga, Tadahiro; Kiyono, Hiroshi; Kunisawa, Jun; Arase, Hisashi

    2015-06-01

    Inflammatory bowel disease is thought to be a complex multifactorial disease, in which an increased inflammatory response plays an important role. Paired immunoglobulin-like type 2 receptor α (PILRα), well conserved in almost all mammals, is an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain. PILRα is mainly expressed on myeloid cells and plays an important role in the regulation of inflammation. In the present study, we investigated the function of PILRα in inflammatory bowel disease using PILRα-deficient mice. When mice were orally administered dextran sulfate sodium (DSS), colonic mucosal injury and inflammation were significantly exacerbated in DSS-treated PILRα-deficient mice compared with wild-type (WT) mice. Flow cytometric analysis revealed that neutrophil and macrophage cell numbers were higher in the colons of DSS-treated PILRα-deficient mice than in those of WT mice. Blockade of CXCR2 expressed on neutrophils using a CXCR2 inhibitor decreased the severity of colitis observed in PILRα-deficient mice. These results suggest that PILRα negatively regulates inflammatory colitis by regulating the infiltration of inflammatory cells such as neutrophils and macrophages.

  20. Decision Support Systems (DSS in Construction Tendering Processes

    Directory of Open Access Journals (Sweden)

    Rosmayati Mohemad

    2010-03-01

    Full Text Available The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support System (DSS components is included in the next section. Furthermore, prior researches on implementation of DSS approaches in tendering processes are discussed in details. Current issues arise from both of paper-based and Web-based tendering processes are outlined. Finally, conclusion is included at the end of this paper.

  1. How essential are Argo observations to constrain a global ocean data assimilation system?

    Science.gov (United States)

    Turpin, V.; Remy, E.; Le Traon, P. Y.

    2016-02-01

    Observing system experiments (OSEs) are carried out over a 1-year period to quantify the impact of Argo observations on the Mercator Ocean 0.25° global ocean analysis and forecasting system. The reference simulation assimilates sea surface temperature (SST), SSALTO/DUACS (Segment Sol multi-missions dALTimetrie, d'orbitographie et de localisation précise/Data unification and Altimeter combination system) altimeter data and Argo and other in situ observations from the Coriolis data center. Two other simulations are carried out where all Argo and half of the Argo data are withheld. Assimilating Argo observations has a significant impact on analyzed and forecast temperature and salinity fields at different depths. Without Argo data assimilation, large errors occur in analyzed fields as estimated from the differences when compared with in situ observations. For example, in the 0-300 m layer RMS (root mean square) differences between analyzed fields and observations reach 0.25 psu and 1.25 °C in the western boundary currents and 0.1 psu and 0.75 °C in the open ocean. The impact of the Argo data in reducing observation-model forecast differences is also significant from the surface down to a depth of 2000 m. Differences between in situ observations and forecast fields are thus reduced by 20 % in the upper layers and by up to 40 % at a depth of 2000 m when Argo data are assimilated. At depth, the most impacted regions in the global ocean are the Mediterranean outflow, the Gulf Stream region and the Labrador Sea. A significant degradation can be observed when only half of the data are assimilated. Therefore, Argo observations matter to constrain the model solution, even for an eddy-permitting model configuration. The impact of the Argo floats' data assimilation on other model variables is briefly assessed: the improvement of the fit to Argo profiles do not lead globally to unphysical corrections on the sea surface temperature and sea surface height. The main conclusion

  2. A comparison of Argo nominal surface and near-surface temperature for validation of AMSR-E SST

    Science.gov (United States)

    Liu, Zenghong; Chen, Xingrong; Sun, Chaohui; Wu, Xiaofen; Lu, Shaolei

    2016-06-01

    Satellite SST (sea surface temperature) from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) is compared with in situ temperature observations from Argo profiling floats over the global oceans to evaluate the advantages of Argo NST (near-surface temperature: water temperature less than 1 m from the surface). By comparing Argo nominal surface temperature (~5 m) with its NST, a diurnal cycle caused by daytime warming and nighttime cooling was found, along with a maximum warming of 0.08±0.36°C during 14:00-15:00 local time. Further comparisons between Argo 5-m temperature/Argo NST and AMSR-E SST retrievals related to wind speed, columnar water vapor, and columnar cloud water indicate warming biases at low wind speed (28 mm during daytime. The warming tendency is more remarkable for AMSR-E SST/Argo 5-m temperature compared with AMSR-E SST/Argo NST, owing to the effect of diurnal warming. This effect of diurnal warming events should be excluded before validation for microwave SST retrievals. Both AMSR-E nighttime SST/Argo 5-m temperature and nighttime SST/Argo NST show generally good agreement, independent of wind speed and columnar water vapor. From our analysis, Argo NST data demonstrated their advantages for validation of satellite-retrieved SST.

  3. Accurate estimation of influenza epidemics using Google search data via ARGO.

    Science.gov (United States)

    Yang, Shihao; Santillana, Mauricio; Kou, S C

    2015-11-24

    Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistical foundation, ARGO outperforms all previously available Google-search-based tracking models, including the latest version of Google Flu Trends, even though it uses only low-quality search data as input from publicly available Google Trends and Google Correlate websites. ARGO not only incorporates the seasonality in influenza epidemics but also captures changes in people's online search behavior over time. ARGO is also flexible, self-correcting, robust, and scalable, making it a potentially powerful tool that can be used for real-time tracking of other social events at multiple temporal and spatial resolutions.

  4. Quality Control of ARGO Data Based on Climatological T-S Models

    Institute of Scientific and Technical Information of China (English)

    纪风颖; 林绍花

    2004-01-01

    By implementing the ARGO program, a large number of T-S profiles can be observed in the world ocean. However, it is very difficult to examine changes of the sensitivity of the sensors equipped at the ARGO floats, because it is difficult to understand their condition in the sea and the reliability of the data. Quality control must be done in order to avoid the wrong conclusion deduced from the wrong data.One of the realistic methods for quality control of the ARGO data is the comparison with the local climatology. High quality climatological T-S models in northwest Pacific have been built based on the Nansen bottle data and CTD data for the quality control in NMDIS. The models are used to check the ARGO data in this area and have got good result.

  5. Using ARGO, GRACE and altimetry to assess the quasi stationary circulation in the North Atlantic

    OpenAIRE

    Richter, Falk; Sidorenko, Dmitry; Danilov, Sergey; Schröter, Jens

    2009-01-01

    The data available from Argo profiling buoys and satellite altimetry are combined into Inverse Finite Element Ocean model (IFEOM) for each of the years 2005 and 2006. The model solves for temperature and salinity fields that are close to measurements, respects quasi-stationary dynamical balances, and simultaneously produces estimates of the circulation. Several experiments have been performed to reconstruct the interannual variability. The assimilation of Argo data alone produces qualitative ...

  6. Artificial Intelligence (AI), Operations Research (OR), and Decision Support Systems (DSS): A conceptual framework

    Science.gov (United States)

    Parnell, Gregory S.; Rowell, William F.; Valusek, John R.

    1987-01-01

    In recent years there has been increasing interest in applying the computer based problem solving techniques of Artificial Intelligence (AI), Operations Research (OR), and Decision Support Systems (DSS) to analyze extremely complex problems. A conceptual framework is developed for successfully integrating these three techniques. First, the fields of AI, OR, and DSS are defined and the relationships among the three fields are explored. Next, a comprehensive adaptive design methodology for AI and OR modeling within the context of a DSS is described. These observations are made: (1) the solution of extremely complex knowledge problems with ill-defined, changing requirements can benefit greatly from the use of the adaptive design process, (2) the field of DSS provides the focus on the decision making process essential for tailoring solutions to these complex problems, (3) the characteristics of AI, OR, and DSS tools appears to be converging rapidly, and (4) there is a growing need for an interdisciplinary AI/OR/DSS education.

  7. Hydrologic Drought Decision Support System (HyDroDSS)

    Science.gov (United States)

    Granato, Gregory E.

    2014-01-01

    The hydrologic drought decision support system (HyDroDSS) was developed by the U.S. Geological Survey (USGS) in cooperation with the Rhode Island Water Resources Board (RIWRB) for use in the analysis of hydrologic variables that may indicate the risk for streamflows to be below user-defined flow targets at a designated site of interest, which is defined herein as data-collection site on a stream that may be adversely affected by pumping. Hydrologic drought is defined for this study as a period of lower than normal streamflows caused by precipitation deficits and (or) water withdrawals. The HyDroDSS is designed to provide water managers with risk-based information for balancing water-supply needs and aquatic-habitat protection goals to mitigate potential effects of hydrologic drought. This report describes the theory and methods for retrospective streamflow-depletion analysis, rank correlation analysis, and drought-projection analysis. All three methods are designed to inform decisions made by drought steering committees and decisionmakers on the basis of quantitative risk assessment. All three methods use estimates of unaltered streamflow, which is the measured or modeled flow without major withdrawals or discharges, to approximate a natural low-flow regime. Retrospective streamflow-depletion analysis can be used by water-resource managers to evaluate relations between withdrawal plans and the potential effects of withdrawal plans on streams at one or more sites of interest in an area. Retrospective streamflow-depletion analysis indicates the historical risk of being below user-defined flow targets if different pumping plans were implemented for the period of record. Retrospective streamflow-depletion analysis also indicates the risk for creating hydrologic drought conditions caused by use of a pumping plan. Retrospective streamflow-depletion analysis is done by calculating the net streamflow depletions from withdrawals and discharges and applying these depletions

  8. ARGO-YBJ:丰富多彩的宇宙线观测%ARGO-YBJ: Fruitful Cosmic Ray Observations

    Institute of Scientific and Technical Information of China (English)

    曹臻

    2012-01-01

    Being smoothly operated for 5 years, the ARGO-YBJ experiment collected 0.4 trillion cosmic ray event samples. Many scientific goals have been achieved based on the very important data base. Here in this article, we summarize all major contributions to cosmic ray related researches, including conventional measurements such as cosmic ray energy spectrum, composition and anisotropy. The researches also cover many non-traditional topics such as the monitoring of solar activity using Galactic cosmic rays, forecasting large geomagnetic storms induced by huge flares of the sun, exploring the correlation between thunderstorms and extensives air shower of cosmic rays and so forth. With the progresses of the future experiment LHAASO, all researches reported in this paper will be greatly enhanced using the most sensitive new generation apparatus. Breakthrough may be expected in some of the topics.

  9. Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.

    Science.gov (United States)

    Arai, Katsuhito; Mizobuchi, Yu; Tokuji, Yoshihiko; Aida, Kazuhiko; Yamashita, Shinji; Ohnishi, Masao; Kinoshita, Mikio

    2015-01-01

    The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.

  10. Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.

    Science.gov (United States)

    Liu, Bo; Lin, Qinlu; Yang, Tao; Zeng, Linna; Shi, Limin; Chen, Yaya; Luo, Feijun

    2015-11-01

    Ulcerative colitis is a major inflammatory bowel disease (IBD), characterized by inflammation within the gastrointestinal tract through chronic or relapsing immune system activation. The aim of this study is to investigate the potential protective effect of oat β-glucan (βG) against colitis induced by DSS in mice. Eighty mice were randomly divided into the control group (no DSS, no βG), DSS group (DSS only), DSS + L-βG group (DSS plus 500 mg per kg βG), and DSS + H-βG group (DSS plus 1000 mg per kg βG). Compared with the DSS group, administration of βG significantly reduced clinical symptoms with less weight loss, diarrhea and shortening of the colon, the severity of colitis was significantly inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in colon. Moreover, treatment with βG not only decreased myeloperoxidase activity (MPO), and nitric oxide (NO) and malondialdehyde (MDA) levels, but also inhibited mRNA and protein expression of pro-inflammatory factors such as TNF-α, IL-1β, IL-6 and iNOS. This suggests that oat βG in diet might exhibit an anti-inflammatory function against colitis through inhibition of expression of pro-inflammatory factors.

  11. Regulation of Rad51-Mediated Homologous Recombination by BRCA2, DSS1 and RAD52

    DEFF Research Database (Denmark)

    Rants, Louise Olthaver Juhl

    in governing the activity of Rad51 and to learn how other recombination-associated proteins such as DSS1 and RAD52 contribute to its regulation. We use the yeast-like fungus Ustilago maydis and the avian DT40 cell line as experimental systems since both have a well-conserved BRCA2-based recombinational repair...... system that resembles the one seen in human. In U. maydis, we show that Brh2, the BRCA2 homologue, and Dss1 colocalize at DNA damage-induced foci, with Dss1 exhibiting a dynamic association with Brh2 foci. Dss1 focus formation is dependent on interaction with full-length Brh2, and the Dss1-Brh2...... interaction is required for resistance to DNA damage. In avian DT40 cells, we show that endogenously tagged DSS1 redistributes into subnuclear foci in response to DNA damaging agents. However, DSS1 rarely colocalizes with BRCA2. Our data also indicate that both U. maydis Dss1 and avian DSS1 are involved...

  12. On the nature of the Madagascar dipoles: An analysis from Argo profiling floats and altimetry measurements

    Science.gov (United States)

    Aguiar-González, Borja; Ponsoni, Leandro; Ridderinkhof, Herman; de Ruijter, Will P. M.; Maas, Leo R. M.

    2016-04-01

    The South East Madagascar Current (SEMC) flows poleward along the eastern coast of Madagascar as a western boundary current which further south provides some of the source waters of the Agulhas Current, either directly or in the form of eddies. We investigate the region of dipole formation south of Madagascar combining vertical T/S profiles from Argo floats, altimetry measurements and an existing eddy detection algorithm. Results from our analysis show that the dipole consists of an anticyclonic intrathermocline eddy (ITE) formed on its southern flank and a cyclonic ITE formed on its northern flank. Both lobes of the dipole exhibit similar T/S properties throughout the water column, although vertically shifted within the thermocline depending on its nature: upward in a cyclonic ITE and downward in an anticyclonic ITE. A subsurface salinity maximum of about 35.5 psu characterizes the upper layers with Subtropical Surface Water (STSW). At intermediate levels, a well defined path of South Indian Central Water (SICW) extends throughout the water column up to reach a minimum in salinity of 34.5 psu, corresponding to Antarctic Intermediate Water (AAIW). Below, at deep layers, the North Atlantic Deep Water (NADW) is found. The intrathermocline nature of the Madagascar dipoles has not been previously reported and represents an important feature to be considered when assessing the heat and salt fluxes driven by eddy movement and contributing to the Agulhas Current. Unlike surface eddies, intrathermocline eddies strongly influence the intermediate/deeper layers in the oceans and, hence, may have a larger contribution in the spreading rates and pathways of water masses. Because the intrathermocline nature of eddies is invisible to altimetry measurements, these results stress the importance of combining altimetry with historical records of Argo profiles which uncover eddy dynamics below the sea surface. Lastly, we further investigate from altimetry the area of dipole formation

  13. What can ARGO's tell us on the processes in Baltic Sea?

    Science.gov (United States)

    Roiha, Petra; Siiriä, Simo-Matti; Nummelin, Aleksi; Aro, Eemeli; Purokoski, Tero

    2014-05-01

    Finnish Meteorological Institute has been testing ARGO floats in the Baltic Sea as a mean for collecting data from the sea areas that are not easily reachable by research vessels or remote sensing. The observational data for Baltic Sea off-shore areas is very sparse and new observational methods are needed to fill the gaps in our knowledge and collect new data for different purposes, such as, operational activities, modelling and ocean science. The ARGO floats have been used successfully in the deep oceans. However, applying the ARGO floats in Baltic Sea is not straight forward, as the conditions differ greatly: the water is brackish, some areas are heavily trafficked and the northern parts freeze during the winter. In addition, the mean depth is only 54 metres, which is only a fraction of depths where ARGO floats have commonly been used. FMI has deployed three ARGO floats in Baltic Sea for different missions. The first ARGO was deployed in 2012 with normal diving algorithm, which checks the pressure hourly. The second float was modified by Aalto University so that the algorithm checks the pressure every 15 minutes. The first float was deployed in the Bothnian Sea in May 2013 and it measured over 200 profiles during its half year mission. The float with faster pressure detection was deployed in the Bothnian Sea in May 2013, and during it's 4 month mission it measured succesfully over 120 profiles. Another, longer test is ongoing on Eastern Gotland basin, where another ARGO float was deployed at Aug 2013, and still measures at Jan 2014. This one differs from earlier experiments as it has additional oxygen and scattering meters, also the area of measurements is deeper (200+ meters). The missions so far indicate, that with proper control and monitoring, ARGO's can be operated, and can measure long series of profiles. In addition to the actual measurements, the movement of ARGO floats gives possibilities to analyse currents in deeper areas of Baltic, and help

  14. The Knee of the Cosmic Hydrogen and Helium Spectrum below 1 PeV Measured by ARGO-YBJ and a Cherenkov Telescope of LHAASO

    CERN Document Server

    Bartoli, B; Bi, X J; Branchini, P; Budano, A; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Chen, S Z; Chen, T L; Creti, P; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liguori, G; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Panareo, M; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G; Bai, Y X; Chen, M J; Chen, Y; Feng, S H; Gao, B; Gu, M H; Hou, C; Li, X X; Liu, J L; Wang, X; Xiao, G; Zhang, B K; Zhang, S S; Zhou, B; Zuo, X

    2015-01-01

    The measurement of cosmic ray energy spectra, in particular for individual species, is an essential approach in finding their origin. Locating the "knees" of the spectra is an important part of the approach and has yet to be achieved. Here we report a measurement of the mixed Hydrogen and Helium spectrum using the combination of the ARGO-YBJ experiment and of a prototype Cherenkov telescope for the LHAASO experiment. A knee feature at 640+/-87 TeV, with a clear steepening of the spectrum, is observed. This gives fundamental inputs to galactic cosmic ray acceleration models.

  15. CRAB NEBULA: FIVE-YEAR OBSERVATION WITH ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S.; D' Ettorre Piazzoli, B.; Di Girolamo, T. [Dipartimento di Fisica dell' Università di Napoli " Federico II," Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A.; De Mitri, I. [Dipartimento Matematica e Fisica " Ennio De Giorgi," Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Camarri, P. [Dipartimento di Fisica dell' Università di Roma " Tor Vergata," via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R.; Di Sciascio, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016 Hebei (China); Dai, B. Z., E-mail: vernetto@to.infn.it [Yunnan University, 2 North Cuihu Rd., 650091 Kunming, Yunnan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2015-01-10

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ∼3.3 × 10{sup 5} events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I {sub 0} (E/2 TeV){sup –α}, with a flux normalization I {sub 0} = (5.2 ± 0.2) × 10{sup –12} photons cm{sup –2} s{sup –1} TeV{sup –1} and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10{sup –11} photons cm{sup –2} s{sup –1}. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I {sub 0} (E/2 TeV){sup –α} exp (–E/E {sub cut}), the lower limit of the cutoff energy E {sub cut} is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10{sup –2}. A correlated analysis with Fermi-LAT data over ∼4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a ''blind'' search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day{sup –1}, consistent with the average value of 137 ± 10 day{sup –1}.

  16. WAR DSS: A DECISION SUPPORT SYSTEM FOR ENVIRONMENTALLY CONSCIOUS CHEMICAL PROCESS DESIGN

    Science.gov (United States)

    The second generation of the Waste Reduction (WAR) Algorithm is constructed as a decision support system (DSS) in the design of chemical manufacturing facilities. The WAR DSS is a software tool that can help reduce the potential environmental impacts (PEIs) of industrial chemical...

  17. Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis

    DEFF Research Database (Denmark)

    Kojic, Milorad; Zhou, Qingwen; Lisby, Michael;

    2005-01-01

    Brh2, the BRCA2 homolog in Ustilago maydis, functions in recombinational repair of DNA damage by regulating Rad51 and is, in turn, regulated by Dss1. Dss1 is not required for Brh2 stability in vivo, nor for Brh2 to associate with Rad51, but is required for formation of green fluorescent protein...

  18. Accuracy of ARGOS locations of Pinnipeds at-sea estimated using Fastloc GPS.

    Directory of Open Access Journals (Sweden)

    Daniel P Costa

    Full Text Available BACKGROUND: ARGOS satellite telemetry is one of the most widely used methods to track the movements of free-ranging marine and terrestrial animals and is fundamental to studies of foraging ecology, migratory behavior and habitat-use. ARGOS location estimates do not include complete error estimations, and for many marine organisms, the most commonly acquired locations (Location Class 0, A, B, or Z are provided with no declared error estimate. METHODOLOGY/PRINCIPAL FINDINGS: We compared the accuracy of ARGOS Locations to those obtained using Fastloc GPS from the same electronic tags on five species of pinnipeds: 9 California sea lions (Zalophus californianus, 4 Galapagos sea lions (Zalophus wollebaeki, 6 Cape fur seals (Arctocephalus pusillus pusillus, 3 Australian fur seals (A. p. doriferus and 5 northern elephant seals (Mirounga angustirostris. These species encompass a range of marine habitats (highly pelagic vs coastal, diving behaviors (mean dive durations 2-21 min and range of latitudes (equator to temperate. A total of 7,318 ARGOS positions and 27,046 GPS positions were collected. Of these, 1,105 ARGOS positions were obtained within five minutes of a GPS position and were used for comparison. The 68(th percentile ARGOS location errors as measured in this study were LC-3 0.49 km, LC-2 1.01 km, LC-1 1.20 km, LC-0 4.18 km, LC-A 6.19 km, LC-B 10.28 km. CONCLUSIONS/SIGNIFICANCE: The ARGOS errors measured here are greater than those provided by ARGOS, but within the range of other studies. The error was non-normally distributed with each LC highly right-skewed. Locations of species that make short duration dives and spend extended periods on the surface (sea lions and fur seals had less error than species like elephant seals that spend more time underwater and have shorter surface intervals. Supplemental data (S1 are provided allowing the creation of density distributions that can be used in a variety of filtering algorithms to improve the

  19. Pengembangan DSS untuk Menentukan Metode Pelatihan E-Learning Berbasis MOODLE bagi Guru SMK

    Directory of Open Access Journals (Sweden)

    Muslikhin Muslikhin

    2013-06-01

    Full Text Available Penelitian ini bertujuan menghasilkan desain DSS dan mengetahui kualitas DSS yang dipakai instruktur dalam menentukan metode pelatihan e-learning berbasis Moodle bagi guru SMK.Penelitian dan pengembangan ini melalui lima fase yaitu: asesmen/analisis, desain, pengembangan, implementasi dan evaluasi. Subyek penelitian adalah guru SMK di Kota Yogyakarta, Sleman dan Magelang 75 responden need assessment and analysis, 15 guru uji beta, 24 guru untuk evaluasi. Instrumen pengumpulan data berupa lembar kuesioner need assessment and analysis, lembar validasi ahli pelatihan, lembar uji alfa, lembar uji beta dan lembar evaluasi pelatihan.HasilpenelitianmenunjukkanDSS memberikan alternatif keputusan secara cepat melalui empat pertimbangan berdasarkan peserta, tujuan, keuntungan, dan level. Hasil uji alfa dan beta DSS menunjukkanskor 4,14dan 4,02 atau kategori “baik”.SedangkanakurasiDSS melalui evaluasi terhadap 24 pesertapelatihane-learningmenunjukkan 88,14%akurat. Kata kunci: DSS, pengambilan keputusan, menentukan metode,pelatihan e-learning.

  20. [Water quality forewarning model in the framework of water pollution forewarning DSS].

    Science.gov (United States)

    Guo, Yu; Jia, Hai-Feng

    2010-12-01

    In order to deal with the water pollution accident and take emergency measures effectively, water pollution forewarning decision support systems (DSS) is important to be established and water quality forewarning model is one of the hard points of DSS. Miyun Reservoir is the most important surface water sources of Beijing. Baihe River, which is the upstream river of Miyun Reservoir, is selected as the case study in this paper. The three-layer frame of the water pollution forewarning DSS is proposed with the core of mathematical model; then model development and parameterization are studied. Finally, a typical accident of NaCN pollution is taken for instance; the scenario of the accident is simulated and analyzed by DSS. The case study shows that the DSS could precisely analyze and forecast the pollution development trend, and simulate the different impact of emergency proposal. The result could support the primary decision of the emergency proposal to meet the functional requirement of the system.

  1. A Modular Decomposition for Approximation of the Optimum DSS in Multidimensional Cases

    Directory of Open Access Journals (Sweden)

    Ivan Vrana

    2013-10-01

    Full Text Available Decision making tasks are often complex and ill-defined, and they are also multi-aspect because many factors influence the decision process. Decision support systems (DSS which are frequently used in business and manufacturing have a potential to cope with vagueness and ill-structure of complex decision making situations. Also an optimum DSS can be developed for multi-dimensional decision problems. Complexity of such a system however rapidly grows with an increasing number of influencing factors, their dimensions and their relationships. As a consequence development, operation and maintenance of the optimum DSS becomes difficult and sometimes even unfeasible for real situations. This paper describes a feasible approximation of the optimum DSS through decreasing its complexity by a modular decomposition. The resulting DSS consists of multiple DSSs, each of them is focused at the individual decision making dimension. Paper also presents a practical simple integration mechanism and heuristic for integrating partial DSSs.

  2. The Application of ARGO Data to the Global Ocean Data Assimilation Operational System of NCC

    Institute of Scientific and Technical Information of China (English)

    LIU Yimin; ZHANG Renhe; YIN Yonghong; NIU Tao

    2005-01-01

    In this paper, we have preliminarily studied the application of ARGO (Array for Real-time Geostrophic Oceanography) data to the Global Ocean Data Assimilation System of National Climate Center of China (NCC-GODAS), which mainly contains 4 sub-systems such as data preprocessing, real-time wind stress calculating, variational analysis and interpolating, and ocean dynamic model. For the sake of using ARGO data, the relevant adjustment and improvement have been made at the corresponding aspects in the subsystems.Using the observation data from 1981 to 2003 including the ARGO data of 2001 to July. 2003, we have performed a series of numerical experiments on this system. Comparing with the corresponding results of NCEP, It is illustrated that using ARGO data can improve the results of NCC-GODAS in the region of the Middle Pacific, for instance SST, SSTA (SST anomalies), Nino index, sea sub-surface temperature,etc. Furthermore, it is obtained that NCC-GODAS benefits from ARGO data in the other regions such as Atlantic Ocean, Indian Ocean, and extratropical Pacific Ocean much more than in the tropical Pacific.

  3. Crab Nebula: five-year observation with ARGO-YBJ

    CERN Document Server

    ,

    2015-01-01

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma ray emission from 2007 November to 2013 February. The integrated signal, consisting of $\\sim$3.3 $\\times$ 10$^5$ events,reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I$_0$ (E / 2 TeV)$^{-\\alpha}$, with a flux normalization I$_0$ = (5.2 $\\pm$ 0.2) $\\times$ 10$^{-12}$ photons cm$^{-2}$ s$^{-1}$ TeV$^{-1}$ and $\\alpha$ = 2.63 $\\pm$ 0.05, corresponding to an integrated flux above 1 TeV of 1.97 $\\times$ 10$^{-11}$ photons cm$^{-2}$ s$^{-1}$. The systematic error is estimated to be less than 30$\\%$ for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I$_0$ (E / 2 TeV)$^{-\\alpha}$ $\\exp$ (-E / E$_{cut}$), the lower limit of the cutoff energy E$_{cut}$ is 12 TeV, at 90$\\%$ confidence level. Our extended dataset allows the study of the TeV emission over lon...

  4. Histopathological and morphometric changes induced by a dextran sodium sulfate (DSS) model in broilers.

    Science.gov (United States)

    Menconi, A; Hernandez-Velasco, X; Vicuña, E A; Kuttappan, V A; Faulkner, O B; Tellez, G; Hargis, B M; Bielke, L R

    2015-05-01

    Oral administration of dextran sodium sulfate (DSS) is commonly used as an inducer of enteric inflammation in rodents. However, there is a dearth of knowledge regarding appropriate dosage, timing, or ageresponses in broilers for this potential inducer of inflammation without necrosis. Two experiments were conducted in day-of-hatch chicks to analyze clinical parameters and enteric histological changes induced by DSS when administered via drinking water ( DW: ). In both experiments, birds were distributed into nontreated control or varying concentrations of DSS in DW. For both experiments, only 0.75% DSS in DW was histologically evaluated. In Experiment 1, chicks received DSS from day 3 to 11, and at 3, 6, and 8 d of treatment, chicks were weighed, and sections of the duodenum, ileum, and ceca were formalin fixed. The addition of 0.75% DSS caused depression, anemia, and watery bloody diarrhea, plus significantly (P DSS administration (P DSS from days 10 to 16 and were sampled at 3 and 6 d of treatment. Similar changes were found in ceca of treated birds. There was no significant change in the duodenal villus height and goblet cell density by 6 d of treatment, suggesting that 6 d of 0.75% DSS in DW was not sufficient for the reproduction of duodenal symptoms in these older birds. However, there was a significant decrease in ilealvillus height and decreased ileal epithelial cell height at 3 and 6 d of treatment, as well as a significant decrease in BW compared to the control group. These findings indicate that DW administration of 0.75% DSS caused generalized mild and non-necrotic enteritis in broilers and that this compound may be useful for enteric inflammation modeling in poultry.

  5. Strength advance design of boiler components for DSS operation

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Tsuyoshi; Tsuta, Toshio; Yamaji, Seiichi; Miyoshi, Teiichi (Kawasaki Heavy Industries Ltd., Kobe, (Japan))

    1989-08-20

    The thermal power plants in the future are expected to operate under such medium loads as LNG, petroleum and coal burning. As a result, frequent start-ups at night (DSS operation) and week-end stops (WSS operation), etc. are conducted: sliding pressure operation system is adopted to reduce the thermal stress at the turbine and to improve the plant efficiency at partial load operation; this causes a rapid temperture change which gives rise to big thermal stress at various points of the boiler causing wide fatigue damage at the center of the stress. Simultneously, the creep damage at high temperature progresses by time. In order to attain sufficient life for the planned operation mode at the design of various boiler points, improvements have been conducted at internal bore edge of a thick cylinder, shape of the fin end piece, furnace/horizontal flue corner part and the attached metal pieces for enhancing the reliability. 1 ref., 9 figs., 1 tab.

  6. Decision Support Systems (DSS) in Construction Tendering Processes

    CERN Document Server

    Mohemad, Rosmayati; Othman, Zulaiha Ali; Noor, Noor Maizura Mohamad

    2010-01-01

    The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS) technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support Sy...

  7. A novel roseobacter phage possesses features of podoviruses, siphoviruses, prophages and gene transfer agents

    Science.gov (United States)

    Zhan, Yuanchao; Huang, Sijun; Voget, Sonja; Simon, Meinhard; Chen, Feng

    2016-07-01

    Bacteria in the Roseobacter lineage have been studied extensively due to their significant biogeochemical roles in the marine ecosystem. However, our knowledge on bacteriophage which infects the Roseobacter clade is still very limited. Here, we report a new bacteriophage, phage DSS3Φ8, which infects marine roseobacter Ruegeria pomeroyi DSS-3. DSS3Φ8 is a lytic siphovirus. Genomic analysis showed that DSS3Φ8 is most closely related to a group of siphoviruses, CbK-like phages, which infect freshwater bacterium Caulobacter crescentus. DSS3Φ8 contains a smaller capsid and has a reduced genome size (146 kb) compared to the CbK-like phages (205–279 kb). DSS3Φ8 contains the DNA polymerase gene which is closely related to T7-like podoviruses. DSS3Φ8 also contains the integrase and repressor genes, indicating its potential to involve in lysogenic cycle. In addition, four GTA (gene transfer agent) genes were identified in the DSS3Φ8 genome. Genomic analysis suggests that DSS3Φ8 is a highly mosaic phage that inherits the genetic features from siphoviruses, podoviruses, prophages and GTAs. This is the first report of CbK-like phages infecting marine bacteria. We believe phage isolation is still a powerful tool that can lead to discovery of new phages and help interpret the overwhelming unknown sequences in the viral metagenomics.

  8. A novel roseobacter phage possesses features of podoviruses, siphoviruses, prophages and gene transfer agents.

    Science.gov (United States)

    Zhan, Yuanchao; Huang, Sijun; Voget, Sonja; Simon, Meinhard; Chen, Feng

    2016-01-01

    Bacteria in the Roseobacter lineage have been studied extensively due to their significant biogeochemical roles in the marine ecosystem. However, our knowledge on bacteriophage which infects the Roseobacter clade is still very limited. Here, we report a new bacteriophage, phage DSS3Φ8, which infects marine roseobacter Ruegeria pomeroyi DSS-3. DSS3Φ8 is a lytic siphovirus. Genomic analysis showed that DSS3Φ8 is most closely related to a group of siphoviruses, CbK-like phages, which infect freshwater bacterium Caulobacter crescentus. DSS3Φ8 contains a smaller capsid and has a reduced genome size (146 kb) compared to the CbK-like phages (205-279 kb). DSS3Φ8 contains the DNA polymerase gene which is closely related to T7-like podoviruses. DSS3Φ8 also contains the integrase and repressor genes, indicating its potential to involve in lysogenic cycle. In addition, four GTA (gene transfer agent) genes were identified in the DSS3Φ8 genome. Genomic analysis suggests that DSS3Φ8 is a highly mosaic phage that inherits the genetic features from siphoviruses, podoviruses, prophages and GTAs. This is the first report of CbK-like phages infecting marine bacteria. We believe phage isolation is still a powerful tool that can lead to discovery of new phages and help interpret the overwhelming unknown sequences in the viral metagenomics. PMID:27460944

  9. 76 FR 63676 - Final Division of Safety Systems Interim Staff Guidance DSS-ISG-2010-01: Staff Guidance Regarding...

    Science.gov (United States)

    2011-10-13

    ... COMMISSION Final Division of Safety Systems Interim Staff Guidance DSS-ISG- 2010-01: Staff Guidance Regarding... final Division of Safety Systems Interim Staff Guidance, (DSS-ISG) DSS- ISG-2010-01, ``Staff Guidance... guidance to the NRC staff reviewer to address the increased complexity of recent spent fuel pool...

  10. Sea surface freshening inferred from SMOS and ARGO salinity: impact of rain

    Directory of Open Access Journals (Sweden)

    J. Boutin

    2012-10-01

    Full Text Available The sea surface salinity (SSS measured from space by the Soil Moisture and Ocean Salinity (SMOS mission has recently been revisited by the European Space Agency first campaign reprocessing. We show that, with respect to the previous version, biases close to land and ice greatly decrease. The accuracy of SMOS SSS averaged over 10 days 100 × 100 km2 in the open ocean and estimated by comparison to ARGO SSS is on the order of 0.3–0.4 in tropical and subtropical regions and 0.5 in a cold region. The mean SSS −0.1 bias observed in the Tropical Pacific Ocean between 5° N and 15° N, relatively to other regions, is suppressed when SMOS rainy events, as detected on SSMIs rain rates, are removed from the SMOS-ARGO comparisons. The SMOS freshening is linearly correlated to SSMIs rain rate with a slope estimated to −0.14 mm−1 h, after correction for rain atmospheric contribution. This tendency is the signature of the temporal SSS variability between the time of SMOS and ARGO measurements linked to rain variability and of the vertical salinity stratification between the first centimeter of the sea surface layer sampled by SMOS and the 5 m depth sampled by ARGO. However, given that the whole set of collocations includes situations with rainy ARGO measurements collocated with non rainy SMOS measurements, the mean −0.1 bias and the negative skewness of the statistical distribution of SMOS minus ARGO SSS difference are very likely the mean signature of the vertical salinity stratification. In the future, the analysis of ongoing in situ salinity measurements in the top 50 cm of the sea surface and of Aquarius satellite SSS are expected to provide complementary information about the sea surface salinity stratification.

  11. CXCR2 knockout mice are protected against DSS-colitis-induced acute kidney injury and inflammation.

    Science.gov (United States)

    Ranganathan, Punithavathi; Jayakumar, Calpurnia; Manicassamy, Santhakumar; Ramesh, Ganesan

    2013-11-15

    Organ cross talk exists in many diseases of the human and animal models of human diseases. A recent study demonstrated that inflammatory mediators can cause acute kidney injury and neutrophil infiltration in a mouse model of dextran sodium sulfate (DSS)-colitis. However, the chemokines and their receptors that may mediate distant organ effects in colitis are unknown. We hypothesized that keratinocyte chemoattractant (KC)/IL-8 receptor chemokine (C-X-C motif) ligand 2 (CXCL2) mediates DSS-colitis-induced acute kidney injury. Consistent with our hypothesis, wild-type (WT) mice developed severe colitis with DSS treatment, which was associated with inflammatory cytokine and chemokine expression and neutrophil infiltration in the colon. DSS-colitis in WT was accompanied by acute kidney injury and enhanced expression of inflammatory cytokines in the kidney. However, CXCR2 knockout mice were protected against DSS-colitis as well as acute kidney injury. Moreover, the expression of cytokines and chemokines and neutrophil infiltration was blunted in CXCR2 knockout mice in the colon and kidney. Administration of recombinant KC exacerbated DSS-colitis-induced acute kidney injury. Our results suggest that KC/IL-8 and its receptor CXCR2 are critical and major mediators of organ cross talk in DSS colitis and neutralization of CXCR2 will help to reduce the incidence of acute kidney injury due to ulcerative colitis and Crohn's disease in humans.

  12. Driving Backwards Using a Semi-Autonomous Smart Wheelchair System (DSS: A Clinical Evaluation

    Directory of Open Access Journals (Sweden)

    Vinod Sharma

    2012-01-01

    Full Text Available Some wheelchair users have difficulty looking backward when backing up in confined spaces due to limited neck range of motion or low vision, which can lead to collisions which may result in personal injury or property damage. The Drive Safe System (DSS was evaluated in a controlled laboratory setting with blindfolded able-bodied individuals on various backward driving tasks. Performance with the DSS was compared with a standard white cane used for navigation assistance by people with visual impairment. Results indicate that the DSS significantly reduced the number of collisions compared to using a cane (p = 0.0001 alone. There was no difference in task completion time when participants were using the cane or the DSS (p = 0.915. Users rated the DSS favourably as they experience less total workload (p = 0.026, less physical demand (p = 0.006, felt less frustrated (p = 0.002 and put less effort (p = 0.007 to achieve better performance when using the DSS, compared to using a cane. These findings suggest that the DSS can be a viable powered mobility solution for wheelchair users with visual impairments.

  13. Argo: enabling the development of bespoke workflows and services for disease annotation.

    Science.gov (United States)

    Batista-Navarro, Riza; Carter, Jacob; Ananiadou, Sophia

    2016-01-01

    Argo (http://argo.nactem.ac.uk) is a generic text mining workbench that can cater to a variety of use cases, including the semi-automatic annotation of literature. It enables its technical users to build their own customised text mining solutions by providing a wide array of interoperable and configurable elementary components that can be seamlessly integrated into processing workflows. With Argo's graphical annotation interface, domain experts can then make use of the workflows' automatically generated output to curate information of interest.With the continuously rising need to understand the aetiology of diseases as well as the demand for their informed diagnosis and personalised treatment, the curation of disease-relevant information from medical and clinical documents has become an indispensable scientific activity. In the Fifth BioCreative Challenge Evaluation Workshop (BioCreative V), there was substantial interest in the mining of literature for disease-relevant information. Apart from a panel discussion focussed on disease annotations, the chemical-disease relations (CDR) track was also organised to foster the sharing and advancement of disease annotation tools and resources.This article presents the application of Argo's capabilities to the literature-based annotation of diseases. As part of our participation in BioCreative V's User Interactive Track (IAT), we demonstrated and evaluated Argo's suitability to the semi-automatic curation of chronic obstructive pulmonary disease (COPD) phenotypes. Furthermore, the workbench facilitated the development of some of the CDR track's top-performing web services for normalising disease mentions against the Medical Subject Headings (MeSH) database. In this work, we highlight Argo's support for developing various types of bespoke workflows ranging from ones which enabled us to easily incorporate information from various databases, to those which train and apply machine learning-based concept recognition models

  14. Intraseasonal Oscillation in Global Ocean Temperature Inferred from Argo

    Institute of Scientific and Technical Information of China (English)

    HU Ruijin; WEI Meng

    2013-01-01

    The intraseasonal oscillation (ISO; 14-97-day periods) of temperature in the upper 2000 m of the global ocean was studied based on Argo observations from 2003-2008.It is shown that near the surface the ISO existed mainly in a band east of 60°E,between 10°S and 10°N,and the region around the Antarctic Circumpolar Current (ACC).At other levels analyzed,the ISOs also existed in the regions of the Kuroshio,the Gulf Stream,the Indonesian throughflow,the Somalia current,and the subtropical countercurrent (STCC) of the North Pacific.The intraseasonal signals can be seen even at depths of about 2000 m in some regions of the global ocean.The largest amplitude of ISO appeared at the thermocline of the equatorial Pacific,Atlantic and Indian Ocean,with maximum standard deviation (STD) exceeding 1.2℃.The ACC,the Kuroshio,and the Gulf Stream regions all exhibited large STD for all levels analyzed.Especially at 1000 m,the largest STD appeared in the south and southeast of South Africa-a part of the ACC,with a maximum value that reached 0.5℃.The ratios of the intraseasonal temperature variance to the total variance at 1000 m and at the equator indicated that,in a considerable part of the global deep ocean,the ISO was dominant in the variations of temperature,since such a ratio exceeded even 50% there.A case study also confirmed the existence of the ISO in the deep ocean.These results provide useful information for the design of field observations in the global ocean.Analysis and discussion are also given for the mechanism of the ISO.

  15. Argo and other tidal structures around the milky way

    Directory of Open Access Journals (Sweden)

    Helio J. Rocha-Pinto

    2006-01-01

    Full Text Available Se realiz o una b usqueda de sobredensidades que pudieran estar asociadas con subestructuras en el halo gal actico en bajas latitudes a partir de una muestra de gigantes M de 2MASS. Bajo la hip otesis de que las poblaciones estelares en la V a L actea exterior deber an de estar distribuidas de manera m as o menos sim etrica, se utilizaron dos m etodos para identi car asimetr as en la distribuci on (l; b de gigantes M de 2MASS que pudieran ser indicios de sobredensidades estelares: (1 la veri caci on directa de simetr a en campos re ejados sobre varios c rculos mayores sim etricos hipot eticos en la Galaxia; y (2 la extracci on de un modelo gal actico sim etrico para la distribuci on de gigantes M a partir de la distribuci on observada. Si bien podemos con rmar varios de los aspectos reportados previamente de la corriente de marea Monoceros, un hallazgo mayor de nuestro trabajo es que el n ucleo aparente del sistema Monoceros no se localiza en Canis Major, como lo han sugerido otras exploraciones, sino con mayor probabilidad a mayor l, en la regi on de la antigua constelaci on Argo (actualmente Puppis, Vela y Carina. Adem as del extenso sistema Monoceros, identi camos varias otras sobredensidades de gigantes M, principalmente a mayores distancias. Algunas de ellas corresponden a sistemas encontrados previamente en Triangulo-Andr omeda y Perseo, mientras que la naturaleza de otros de menor signi cado permanece incierta o puede ser atribuida a asimetr as de primer plano de estrellas enanas M contaminantes.

  16. E-Procurement System with Embedded Supplier Selection DSS for an Automobile Manufacturing Industry

    Directory of Open Access Journals (Sweden)

    P.Priya

    2012-05-01

    Full Text Available This paper presents the development of Decision Support System (DSS to enable the selection of best suppliers in an e-procurement process. The model base of the DSS incorporates the Online Analytical Processing (OLAP and Analytic Hierarchy Process (AHP techniques to shortlist and selects the best suppliers in a web environment. The e-DSS process is implemented using ASP and SQL server, for an Indian automobile manufacturing industry. The results obtained for supplier selection is competitive in terms of the quality and lead time of the chosen suppliers

  17. Argos: Internacionalización en un entorno de conflicto armado Argos: Internacionalización en un entorno de conflicto armado*

    Directory of Open Access Journals (Sweden)

    Juan David Penagos Tascón

    2008-12-01

    Full Text Available This case study illustrates how Argos achieved to become one of the largest cement and concrete suppliers of Latin America, in spite of the fact that some of its production facilities are located in armed conflict areas. For that reason, the company implemented various corporate social responsibility strategies to overcome the difficulties of operating in these areas. These strategies contributed to the consolidation of the company’s operations under a single juridical and administrative entity, and facilitated the internationalization process to Central America, the Caribbean and the United States.Este caso de estudio empresarial muestra cómo la compañía Argos logró convertirseen uno de los proveedores de cemento y concreto más grandes de Latinoamérica,a pesar de que algunas de sus plantas productoras se encontraban ubicadas enzonas de conflicto armado, razón por la cual se desarrollaron diferentes iniciativasde responsabilidad social corporativa que permitieron operar en estas zonas.Garantizada la continuidad del negocio, las autoridades de Argos decidenconsolidar todas sus operaciones en una sola razón jurídica y administrativa yllevar a la empresa a un proceso de internacionalización en Centroamérica, Caribey Estados Unidos.

  18. GREENER CHEMICAL PROCESS DESIGN ALTERNATIVES ARE REVEALED USING THE WASTE REDUCTION DECISION SUPPORT SYSTEM (WAR DSS)

    Science.gov (United States)

    The Waste Reduction Decision Support System (WAR DSS) is a Java-based software product providing comprehensive modeling of potential adverse environmental impacts (PEI) predicted to result from newly designed or redesigned chemical manufacturing processes. The purpose of this so...

  19. The UNITE-DSS Modelling System: Risk Simulation and Decision Conferencing

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Barfod, Michael Bruhn

    This presentation introduces the brand new approach of integrating risk simulation and decision conferencing within transport project appraisal (UNITE-DSS model). The modelling approach is divided into various modules respectively as point estimates (cost-benefit analysis), stochastic interval...

  20. On-line satellite/central computer facility of the Multiparticle Argo Spectrometer System

    International Nuclear Information System (INIS)

    An on-line satellite/central computer facility has been developed at Brookhaven National Laboratory as part of the Multiparticle Argo Spectrometer System (MASS). This facility consisting of a PDP-9 and a CDC-6600, has been successfully used in study of proton-proton interactions at 28.5 GeV/c. (U.S.)

  1. Tudengid teevad oma kohviku / Argo Ralja ; intervjueerinud Triinu Püvi

    Index Scriptorium Estoniae

    Ralja, Argo

    2012-01-01

    Intervjuu Tallinna Ülikooli Üliõpilaskonna esimehe Argo Raljaga, kes on olnud tihedalt seotud kohviku idee elluviimisega. Üliõpilaskohvik hakkab asuma ülikoolilinnakus Astra majas ning projekt on usaldatud Üliõpilaskonna kätesse

  2. Parametric improvement for the ingestion dose module of the European ARGOS and RODOS decision support systems

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Nielsen, Sven Poul; Thørring, H.;

    2011-01-01

    The European decision support systems ARGOS and RODOS rely on the ECOSYS model for prognoses of ingestion doses. ECOSYS needs an update of various parameter values to provide reliable estimates. This paper reports on some results of a Nordic initiative to derive parameter values that are specific...

  3. Improving ingestion dose modelling for the ARGOS and RODOS decision support systems: A Nordic Initiative

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Nielsen, Sven Poul; Thørring, Håvard;

    2011-01-01

    A Nordic work group under the NKS-B activity PARDNOR has revised the input parameters in the ECOSYS model that is incorporated for ingestion dose modelling in the ARGOS and RODOS decision support systems. The new parameterisation takes into account recent measurement data, and targets the model f...

  4. Üks suund, kaks vaadet / Tiit Land, Argo Ralja ; intervjueerinud Katrin Reimann

    Index Scriptorium Estoniae

    Land, Tiit, 1964-

    2012-01-01

    Intervjuu Tallinna Ülikooli rektori Tiit Landi ja Üliõpilaskonna juhatuse esimehe Argo Raljaga Tallinna Ülikooli iseloomustavatest märksõnadest möödunud aastal, positsioonist Eesti hariduses, ülikooli koostööst instituutide ja kolledžitega

  5. Aptychi from the Lower Cretaceous strata along the Río Argos (Caravaca, SE Spain)

    NARCIS (Netherlands)

    Vašícek, Z.; Hoedemaeker, Ph.J.

    1997-01-01

    The aptychi of the Berriasian to Barremian strata of the Río Argos succession near Caravaca (SE Spain) are described. One new subspecies is introduced, Lamellaptychus angulocostatus gracilicostatus, from the latest Hauterivian Ohmi Zone (ammonite zone). Like in the Eastern Alps also in Southern Spai

  6. BIO ARGO floats: tools for operational monitoring of the Black Sea

    Science.gov (United States)

    Palazov, Atanas; Slabakova, Violeta; Peneva, Elisaveta; Stanev, Emil

    2014-05-01

    The assessment of ecological status in the context of the Water Framework Directive (WFD) and Marine Strategy Framework Directive (MSFD) requires comprehensive knowledge and understanding of the physical and biogeochemical processes that determine the functioning of marine ecosystems. One of the main challenges however is the need of data with frequency relevant to the spatial and temporal scales of the ecological processes. The majority of in situ observations that are commonly used for ecological monitoring of the Black Sea are generally based on near-shore monitoring programs or irregular oceanographic cruises that provide either non-synoptic, coarse resolution realizations of large scale processes or detailed, but time and site specific snapshots of local features. These gaps can be filled by two independent sources: satellite observation and profiling floats. In fact satellite ocean color sensors allows for determination at synoptic scale of water quality parameters through its absorption properties. However the satellite ocean color methods have a number of limitations such as: measurements can only be made during daylight hours; require cloud-free conditions and are sensitive to atmospheric aerosols; provide information only for the upper layer of the ocean (approximately the depth of 10% incident light); algorithms developed for global applications are a source of large uncertainties in the marginal seas and costal areas. These constrains of the optical remote sensing observations can be avoided by using miniature biogeochemical sensors and autonomous platforms that offer remarkable perspectives for observing the "biological" ocean, notably at critical spatiotemporal scales which have been out of reach until recently (Claustre et al., 2010). In the frame of "E-AIMS: Euro-Argo Improvements for the GMES marine Service" 7 EC FP project two Bio Argo floats were deployed in the Black Sea. Beside the traditionally CTD the floats were equipped with biogeochemical

  7. Vertical temperature dynamics in the Northern Baltic Sea based on 3D modelling and data from shallow-water Argo floats

    Science.gov (United States)

    Westerlund, Antti; Tuomi, Laura

    2016-06-01

    3D hydrodynamic models often produce errors in the depth of the mixed layer and the vertical density structure. We used the 3D hydrodynamic model NEMO to investigate the effect of vertical turbulence parameterisations on seasonal temperature dynamics in the Bothnian Sea, Baltic Sea for the years 2012 and 2013. We used vertical profiles from new shallow-water Argo floats, operational in the area since 2012, to validate our model. We found that NEMO was able to reproduce the general features of the seasonal temperature variations in the study area, when meteorological forcing was accurate. The k-ε and k-ω schemes were selected for a more detailed analysis. Both schemes showed clear differences, but neither proved superior. While sea surface temperature was better simulated with the k-ω scheme, thermocline depth was clearly better with the k-ε scheme. We investigated the effect of wave-breaking on the mixing of the surface layer. The Craig and Banner parameterisation clearly improved the representation of thermocline depth. However, further tuning of the mixing parameterisations for the Baltic Sea is needed to better simulate the vertical temperature structure. We found the autonomous Baltic Sea Argo floats valuable for model validation and performance evaluation.

  8. Hydrodynamic variability of the Cretan Sea derived from Argo float profiles and multi-parametric buoy measurements during 2010-2012

    Science.gov (United States)

    Kassis, Dimitris; Korres, Gerasimos; Petihakis, George; Perivoliotis, Leonidas

    2015-12-01

    In this work, we examine the complex hydrology of the Cretan Sea, an important area which affects the dynamics of the Eastern Mediterranean basin. We use T/S profile data derived from the first Argo float deployed in the area during June 2010 within the framework of the Greek Argo program. Temperature and salinity profiles were measured over a 2-year period, analyzed, and combined with time series data recorded from the POSEIDON E1-M3A multi-parametric instrumentation platform operating in the area since 2007. The acquired datasets have been enriched with available CTD profiles taken on the mooring site during cruise maintenance surveys. The combined research activities resulted in a large dataset of physical properties allowing extended geographical coverage and an in-depth analysis of the Cretan Sea dynamics during this 2-year period. Data analysis shows significant variability of water masses of different origin at subsurface and deep layers. This confirms previous findings describing the area as transitional with water masses of different origin meeting and interacting. Furthermore, additional features of the area are described combining information from satellite altimetry. In this study, new circulation systems are identified at intermediate and subsurface layers affecting both the dynamic behavior of the basin's upper thermocline and the intermediate/deep water mass tempo-spatial variability. We further investigate the physical properties of the water column and suggest an updated mesoscale circulation picture based on the dynamics of the variable hydrological regimes of the Cretan Sea basin.

  9. Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction.

    Directory of Open Access Journals (Sweden)

    Johan Dicksved

    Full Text Available Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective effect is still unknown. In the present study a combination of culture dependent and molecular based T-RFLP profiling was used to investigate the influence of L. reuteri on the colonic mucosal barrier of DSS treated rats. It was first demonstrated that the two colonic mucus layers of control animals had different bacterial community composition and that fewer bacteria resided in the firmly adherent layer. During DSS induced colitis, the number of bacteria in the inner firmly adherent mucus layer increased and bacterial composition of the two layers no longer differed. In addition, induction of colitis dramatically altered the microbial composition in both firmly and loosely adherent mucus layers. Despite protecting against colitis, treatment with L. reuteri did not improve the integrity of the mucus layer or prevent distortion of the mucus microbiota caused by DSS. However, L. reuteri decreased the bacterial translocation from the intestine to mesenteric lymph nodes during DSS treatment, which might be an important part of the mechanisms by which L. reuteri ameliorates DSS induced colitis.

  10. Temperature, salinity and dissolved oxygen profile data from globally distributed Argo profiling floats through the month of September 2016 for the Global Argo Data Repository, 1995-09-07 to 2016-09-30 (NODC Accession 0042682)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent all data collected from Argo profiling floats through the current month (September 2016). The NOAA National Centers for Environmental...

  11. DECISIONS, METHODS AND TECHNIQUES RELATED TO DECISION SUPPORT SYSTEMS (DSS

    Directory of Open Access Journals (Sweden)

    Boghean Florin

    2015-07-01

    Full Text Available Generalised uncertainty, a phenomenon that today’s managers are facing as part of their professional experience, makes it impossible to anticipate the way the business environment will evolve or what will be the consequences of the decisions they plan to implement. Any decision making process within the company entails the simultaneous presence of a number of economic, technical, juridical, human and managerial variables. The development and the approval of a decision is the result of decision making activities developed by the decision maker and sometimes by a decision support team or/and a decision support system (DSS. These aspects related to specific applications of decision support systems in risk management will be approached in this research paper. Decisions in general and management decisions in particular are associated with numerous risks, due to their complexity and increasing contextual orientation. In each business entity, there are concerns with the implementation of risk management in order to improve the likelihood of meeting objectives, the trust of the parties involved, increase the operational safety and security as well as the protection of the environment, minimise losses, improve organisational resilience in order to diminish the negative impact on the organisation and provide a solid foundation for decision making. Since any business entity is considered to be a wealth generator, the analysis of their performance should not be restricted to financial efficiency alone, but will also encompass their economic efficiency as well. The type of research developed in this paper entails different dimensions: conceptual, methodological, as well as empirical testing. Subsequently, the conducted research entails a methodological side, since the conducted activities have resulted in the presentation of a simulation model that is useful in decision making processes on the capital market. The research conducted in the present paper

  12. CRED APEX Drifting Buoy Argos_ID 25321 Data in the Northwestern Hawaiian Islands, 200110-200404 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 25321 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  13. CRED SVP Drifting Buoy Argos_ID 24753 Data in American Samoa, 200307-200407 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24753 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  14. CRED SVP Drifting Buoy Argos_ID 44765 Data, Manua in the American Samoa, 200402-200406 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 44765 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  15. CRED APEX Drifting Buoy Argos_ID 25330 Data Maro Reef, Northwestern Hawaiian Islands, 200109-200201 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 25330 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  16. CRED SVP Drifting Buoy Argos_ID 30147 Data Nihoa, Northwestern Hawaiian Islands, 200209-200501 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30147 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  17. CRED SVP Drifting Buoy Argos_ID 29099 Data, Rota in the Marianas Archipelago, 200309-200402 (NODC Accession 0067473)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29099 was deployed in the region of Marianas Archipelago to assess ocean currents and sea surface temperature. SVP drifter data files...

  18. CRED SVP Drifting Buoy Argos_ID 52299 Data, Arakane in the Marianas Archipelago, 200509-200607 (NODC Accession 0067473)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 52299 was deployed in the region of the Marianas Archipelago to assess ocean currents and sea surface temperature. drifter data files...

  19. CRED SVP Drifting Buoy Argos_ID 30225 Data in the Northwestern Hawaiian Islands, 200209-200401 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30225 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  20. CRED SVP Drifting Buoy Argos_ID 29938 Data in the Northwestern Hawaiian Islands, 200209-200312 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29938 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  1. CRED SVP Drifting Buoy Argos_ID 24666 Data in the American Samoa, 200309-200503 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24666 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  2. CRED SVP Drifting Buoy Argos_ID 35646 Data in the American Samoa, 200202-200302 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 35646 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  3. CRED APEX Drifting Buoy Argos_ID 25333 Data in the NW Hawaiian Islands, 200110-200204 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 25333 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  4. CRED SVP Drifting Buoy Argos_ID 35644 Data Tau, American Samoa, 200202-200207 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 35644 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  5. Enhancing the use of Argos satellite data for home range and long distance migration studies of marine animals.

    Directory of Open Access Journals (Sweden)

    Xavier Hoenner

    Full Text Available Accurately quantifying animals' spatial utilisation is critical for conservation, but has long remained an elusive goal due to technological impediments. The Argos telemetry system has been extensively used to remotely track marine animals, however location estimates are characterised by substantial spatial error. State-space models (SSM constitute a robust statistical approach to refine Argos tracking data by accounting for observation errors and stochasticity in animal movement. Despite their wide use in ecology, few studies have thoroughly quantified the error associated with SSM predicted locations and no research has assessed their validity for describing animal movement behaviour. We compared home ranges and migratory pathways of seven hawksbill sea turtles (Eretmochelys imbricata estimated from (a highly accurate Fastloc GPS data and (b locations computed using common Argos data analytical approaches. Argos 68(th percentile error was 4 km for LC ≤ 0. Argos error structure was highly longitudinally skewed and was, for all LC, adequately modelled by a Student's t distribution. Both habitat use and migration routes were best recreated using SSM locations post-processed by re-adding good Argos positions (LC 1, 2 and 3 and filtering terrestrial points (mean distance to migratory tracks ± SD = 2.2 ± 2.4 km; mean home range overlap and error ratio = 92.2% and 285.6 respectively. This parsimonious and objective statistical procedure however still markedly overestimated true home range sizes, especially for animals exhibiting restricted movements. Post-processing SSM locations nonetheless constitutes the best analytical technique for remotely sensed Argos tracking data and we therefore recommend using this approach to rework historical Argos datasets for better estimation of animal spatial utilisation for research and evidence-based conservation purposes.

  6. MAG-EPA reduces severity of DSS-induced colitis in rats.

    Science.gov (United States)

    Morin, Caroline; Blier, Pierre U; Fortin, Samuel

    2016-05-15

    Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EPA) in an in vivo rats model of UC induced by dextran sulfate sodium (DSS). DSS rats were untreated or treated per os with MAG-EPA. Morphological, histological, and biochemical analyses were performed following MAG-EPA administrations. Morphological and histological analyses revealed that MAG-EPA pretreatment (12 days pre-DSS) and treatment (6 days post-DSS) exhibited strong activity in reducing severity of disease in DSS rats. Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were markedly lower compared with rats treated only with DSS. MAG-EPA per os administration decrease neutrophil infiltration in colon tissues, as depicted by myelohyperoxidase activity. Results also revealed a reduced activation of NF-κB pathways correlated with a decreased expression of COX-2 in colon homogenates derived from MAG-EPA-pretreated and treated rats. Tension measurements performed on colon tissues revealed that contractile responses to methacholine and relaxing effect induced by sodium nitroprusside were largely increased following MAG-EPA treatment. The combined treatment of MAG-EPA and vitamin E displayed an antagonistic effect on anti-inflammatory properties of MAG-EPA in DSS rats.

  7. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis.

    Science.gov (United States)

    Carlsson, Anders H; Yakymenko, Olena; Olivier, Isabelle; Håkansson, Fathima; Postma, Emily; Keita, Asa V; Söderholm, Johan D

    2013-10-01

    OBJECTIVE. The intestinal microbiota plays a substantial role in the pathogenesis of inflammatory bowel disease (IBD). Faecalibacterium prausnitzii (FP) is underrepresented in IBD patients and have been suggested to have anti-inflammatory effects in mice. Increased intestinal permeability is common in IBD but the relationship between FP and intestinal barrier function has not been investigated. Our aim was to study treatment with FP supernatant on intestinal barrier function in a dextran sodium sulfate (DSS) colitis mice model. MATERIAL AND METHODS. C57BL/6 mice received 3% DSS in tap water ad libitum during five days to induce colitis. From day 3 the mice received a daily gavage with FP supernatant or broth during seven days. Ileum and colon were mounted in Ussing chambers for permeability studies with (51)Cr-EDTA and Escherichia coli K-12. Colon was saved for Western blot analyses of tight junction proteins. RESULTS. DSS-treated mice showed significant weight loss and colon shortening. Gavage with FP supernatant resulted in a quicker recovery after DSS treatment and less extensive colonic shortening. Ileal mucosa of DSS mice showed a significant increase in (51)Cr-EDTA-passage compared to controls. (51)Cr-EDTA passage was significantly decreased in mice receiving FP supernatant. No significant differences were observed in passage of E. coli K12. Western blots showed a trend to increased claudin-1 and claudin-2 expressions in DSS mice. CONCLUSIONS. Supernatant of FP enhances the intestinal barrier function by affecting paracellular permeability, and may thereby attenuate the severity of DSS-induced colitis in mice. These findings suggest a potential role of FP in the treatment of IBD.

  8. Sea surface freshening inferred from SMOS and ARGO salinity: impact of rain

    Directory of Open Access Journals (Sweden)

    J. Boutin

    2013-02-01

    Full Text Available The sea surface salinity (SSS measured from space by the Soil Moisture and Ocean Salinity (SMOS mission has recently been revisited by the European Space Agency first campaign reprocessing. We show that, with respect to the previous version, biases close to land and ice greatly decrease. The accuracy of SMOS SSS averaged over 10 days, 100 × 100 km2 in the open ocean and estimated by comparison to ARGO (Array for Real-Time Geostrophic Oceanography SSS is on the order of 0.3–0.4 in tropical and subtropical regions and 0.5 in a cold region. The averaged negative SSS bias (−0.1 observed in the tropical Pacific Ocean between 5° N and 15° N, relatively to other regions, is suppressed when SMOS observations concomitant with rain events, as detected from SSM/Is (Special Sensor Microwave Imager rain rates, are removed from the SMOS–ARGO comparisons. The SMOS freshening is linearly correlated to SSM/Is rain rate with a slope estimated to −0.14 mm−1 h, after correction for rain atmospheric contribution. This tendency is the signature of the temporal SSS variability between the time of SMOS and ARGO measurements linked to rain variability and of the vertical salinity stratification between the first centimeter of the sea surface layer sampled by SMOS and the 5 m depth sampled by ARGO. However, given that the whole set of collocations includes situations with ARGO measurements concomitant with rain events collocated with SMOS measurements under no rain, the mean −0.1 bias and the negative skewness of the statistical distribution of SMOS minus ARGO SSS difference are very likely the mean signature of the vertical salinity stratification. In the future, the analysis of ongoing in situ salinity measurements in the top 50 cm of the sea surface and of Aquarius satellite SSS are expected to provide complementary information about the sea surface salinity stratification.

  9. [Water quality forewarning model in the framework of water pollution forewarning DSS].

    Science.gov (United States)

    Guo, Yu; Jia, Hai-Feng

    2010-12-01

    In order to deal with the water pollution accident and take emergency measures effectively, water pollution forewarning decision support systems (DSS) is important to be established and water quality forewarning model is one of the hard points of DSS. Miyun Reservoir is the most important surface water sources of Beijing. Baihe River, which is the upstream river of Miyun Reservoir, is selected as the case study in this paper. The three-layer frame of the water pollution forewarning DSS is proposed with the core of mathematical model; then model development and parameterization are studied. Finally, a typical accident of NaCN pollution is taken for instance; the scenario of the accident is simulated and analyzed by DSS. The case study shows that the DSS could precisely analyze and forecast the pollution development trend, and simulate the different impact of emergency proposal. The result could support the primary decision of the emergency proposal to meet the functional requirement of the system. PMID:21360873

  10. CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice.

    Directory of Open Access Journals (Sweden)

    Julia M Martínez Gómez

    Full Text Available BACKGROUND: CD137 and its ligand (CD137L are potent immunoregulatory molecules that influence activation, proliferation, differentiation and cell death of leukocytes. Expression of CD137 is upregulated in the lamina propria cells of Crohn's disease patients. Here, the role of CD137 in acute Dextran-Sodium-Sulfate (DSS-induced colitis in mice was examined. METHODS: We induced acute large bowel inflammation (colitis via DSS administration in CD137(-/- and wild-type (WT mice. Colitis severity was evaluated by clinical parameters (weight loss, cytokine secretion in colon segment cultures, and scoring of histological inflammatory parameters. Additionally, populations of lamina propria mononuclear cells (LPMNC and intraepithelial lymphocytes (IEL were characterized by flow cytometry. In a subset of mice, resolution of intestinal inflammation was evaluated 3 and 7 days after withdrawal of DSS. RESULTS: We found that both CD137(-/- and WT mice demonstrated a similar degree of inflammation after 5 days of DSS exposure. However, the resolution of colonic inflammation was impaired in the absence of CD137. This was accompanied by a higher histological score of inflammation, and increased release of the pro-inflammatory mediators granulocyte macrophage colony-stimulating factor (GM-CSF, CXCL1, IL-17 and IFN-γ. Further, there were significantly more neutrophils among the LPMNC of CD137(-/- mice, and reduced numbers of macrophages among the IEL. CONCLUSION: We conclude that CD137 plays an essential role in the resolution of acute DSS-induced intestinal inflammation in mice.

  11. Global representation of tropical cyclone-induced short-term ocean thermal changes using Argo data

    Science.gov (United States)

    Cheng, L.; Zhu, J.; Sriver, R. L.

    2015-09-01

    Argo floats are used to examine tropical cyclone (TC) induced ocean thermal changes on the global scale by comparing temperature profiles before and after TC passage. We present a footprint method that analyzes cross-track thermal responses along all storm tracks during the period 2004-2012. We combine the results into composite representations of the vertical structure of the average thermal response for two different categories: tropical storms/tropical depressions (TS/TD) and hurricanes. The two footprint composites are functions of three variables: cross-track distance, water depth and time relative to TC passage. We find that this footprint strategy captures the major features of the upper-ocean thermal response to TCs on timescales up to 20 days when compared against previous case study results using in situ measurements. On the global scale, TCs are responsible for 1.87 PW (11.05 W m-2) of heat transfer annually from the global ocean to the atmosphere during storm passage (0-3 days). Of this total, 1.05 ± 0.20 PW (4.80 ± 0.85 W m-2) is caused by TS/TD and 0.82 ± 0.21 PW (6.25 ± 1.5 W m-2) is caused by hurricanes. Our findings indicate that ocean heat loss by TCs may be a substantial missing piece of the global ocean heat budget. Changes in ocean heat content (OHC) after storm passage are estimated by analyzing the temperature anomalies during wake recovery following storm events (4-20 days after storm passage) relative to pre-storm conditions. Results indicate the global ocean experiences a 0.75 ± 0.25 PW (5.98 ± 2.1 W m-2) heat gain annually for hurricanes. In contrast, under TS/TD conditions, the ocean experiences 0.41 ± 0.21 PW (1.90 ± 0.96 W m-2) ocean heat loss, suggesting the overall oceanic thermal response is particularly sensitive to the intensity of the event. The ocean heat uptake caused by all storms during the restorative stage is 0.34 PW.

  12. Mesoscale variability of water masses in the Arabian Sea as revealed by ARGO floats

    Directory of Open Access Journals (Sweden)

    X. Carton

    2012-03-01

    Full Text Available By analysing ARGO float data over the last four years, a few aspects of the mesoscale variability of water masses in the Arabian Sea are described.

    The Red Sea Outflow Water (RSOW is concentrated in the Southwestern Gulf of Aden, in particular when a cyclonic gyre predominates in this region. Salinities of 36.5 and temperatures of 16 °C are found in this area at depths between 600 and 1000 m. RSOW is more dilute in the eastern part of the Gulf, where intense and relatively barotropic gyres mix it with Indian ocean Central Water. RSOW is also detected along the northeastern coast of Socotra, and fragments of RSOW are found between one and three degrees of latitude north of this island. In the whole Gulf of Aden, the correlation between the deep motions of the floats and the sea-level anomaly measured by altimetry is strong, at regional scale. The finer scale details of the float trajectories are not sampled by altimetry and are often related to the anomalous water masses that the floats encounter.

    The Persian Gulf Water (PGW is found in the float profiles near Ras ash Sharbatat (near 57° E, 18° N, again with 36.5 in salinity and about 18–19 °C in temperature. These observations were achieved in winter when the southwestward monsoon currents can advect PGW along the South Arabian coast. Fragments of PGW were also observed in the Arabian Sea between 18 and 20° N and 63 and 65° E in summer, showing that this water mass can escape the Gulf of Oman southeastward, during that season.

    Kinetic energy distributions of floats with respect to distance or angle share common features between the two regions (Gulf of Aden and Arabian Sea, in particular peaks at 30, 50 and 150 km scales and along the axis of monsoon currents. Hydrological measurements by floats are also influenced by the seasonal variations of PGW and RSOW in these regions.

  13. Typical Surface Seasonal Circulation in the Indian Ocean Derived from Argos Floats

    Institute of Scientific and Technical Information of China (English)

    ZHENG Shao-Jun; ZHANG Yu-Hong; ZHUANG Wei; LI Jia-Xun; DU Yan

    2012-01-01

    This study investigates the surface circulation in the Indian Ocean using Argos float data over the period 1979--2011. The Argos observations manifest some new phenomena. The climatological annual mean circulation shows that the surface current becomes much stronger after turning around in shore in the western Indian Ocean. In the tropical Indian Ocean, the Great Whirl (GW) to the east of Somalia develops quickly in spring (April-May) as the monsoon reverses to move northward, becoming strongest in summer (June-September) and disappearing in autumn (October-November). The west end of the Agulhas retroflection can reach 18°E, and it exhibits a seasonal variation. At approximately 90°E, the Agulhas Return Current combines with the eastward South Atlantic Current and finally joins the Antarctic Circumpolar Current.

  14. Improvement of bias detection in Argo float conductivity sensors and its application in the North Atlantic

    Science.gov (United States)

    Cabanes, Cécile; Thierry, Virginie; Lagadec, Catherine

    2016-08-01

    We propose modifications of the OW method (Owens and Wong, 2009) used to estimate the time-varying correction of conductivity measurements from Argo floats. These modifications are necessary to account for large interannual to decadal variability of the large-scale salinity field observed, for instance, in the North-Atlantic Ocean and to provide corrections with realistic error bars. The covariance function used to map reference salinity data at the float profile position was modified in order to minimize the contribution of the oldest reference data to the large-scale salinity field estimate. Mapping error now includes errors in the large-scale field estimates and fit error now takes into account the lateral dependence between climatological profiles. Finally, we used the modified OW method to check the consistency of the Argo salinity dataset available in delayed mode in the North-Atlantic Ocean. Overall, salinity corrections need to be reconsidered for 4.5% of the floats.

  15. Origins and pathways of the subsurface and intermediate water masses of the Indonesian Throughflow derived from historical and Argo data

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yanhui; YU Xiaolin; WANG Fan

    2008-01-01

    On the basis of Argo data and historic temperature/salinity data from the World Ocean Database 2001(WOD01),origins and spreading pathways of the subsurface and intermediate water masses in the Indonesian Throughflow (ITF) region were discussed by analyzing distributions of salinity on representative isepycnal layers.Results were shown that,subsurface water mostly comes from the North Pacific Ocean while the intermediate water originates from both the North and South Pacific Ocean,even possibly from the Indian Ocean.Spreading through the Sulawesi Sea,the Makassar Strait,and the Flores Sea,the North Pacific subsurface water and the North Pacific Intermediate water dominate the western part of the Indonesian Archipelago.Furthermore as the depth increases,the features of the North Pacific sourced water masses become more obvious.In the eastern part of the waters,high sa-1inity South Pacific subsurface water is blocked by a strong salinity front between Halmahera and New Guinea.Intermediate water in the eastern interior region owns salinity higher than the North Pacific intermediate water and the antarctic intermediate water (AAIW),possibly coming from the vertical mixing between subsurface water and the AAIW from the Pacific Ocean,and possibly coming from the northward extending of the AAIW from the Indian Ocean as well.

  16. Using Altimetry, GRACE and Argo to assess stationary circulation and transports in the North Atlantic

    OpenAIRE

    Richter, Falk; Sidorenko, Dmitry; Schröter, Jens

    2010-01-01

    The data available from satellite altimetry and Argo profiling buoys are combined into Inverse Finite Element Ocean model (IFEOM) for each of the years 1999 and 2008. The model solves for temperature and salinity fields that are close to measurements, respects stationary dynamical balances, and simultaneously produces estimates of the circulation. Several experiments have been performed to reconstruct the interannual variability. We show, that including altimetry improves the circulation pict...

  17. The development of an EDSS: Lessons learned and implications for DSS research

    Science.gov (United States)

    El-Gayar, O.; Deokar, A.; Michels, L.; Fosnight, G.

    2011-01-01

    The Solar and Wind Energy Resource Assessment (SWERA) project is focused on providing renewable energy (RE) planning resources to the public. Examples include wind, solar, and hydro assessments. SWERA DSS consists of three major components. First, SWERA 'Product Archive' provides for a discovery DSS upon which users can find and access renewable energy data and supporting models. Second, the 'Renewable Resource EXplorer' (RREX) component serves as a web-based, GIS analysis tool for viewing RE resource data available through the SWERA Product Archive. Third, the SWERA web service provides computational access to the data available in the SWERA spatial database through a location based query, and is also utilized in the RREX component. We provide a discussion of various design decisions used in the construction of this EDSS, followed by project experiences and implications for EDSS and broader DSS research. ?? 2011 IEEE.

  18. SMOS validation using SSS data from Barcelona World Race and Argo profilers

    Science.gov (United States)

    Umbert, M.; Ballabrera, J.; Fernandez, P.; Salat, J.; Salvador, J.

    2012-04-01

    The organisers of the Barcelona World Race (BWR), the Institute of Marine Sciences (ICM-CSIC) and the Maritime Catalan Forum (FMC) agreed on equiping the FMC boat, participating in the race, with a SeaBird MiniCTD. The idea was for the first time to explore how such oceanic races could help to monitor surface temperature and salinity all around the world ocean in real time. The boat spent 112 days to complete the rond trip, sending 12-30 real-time samples/day via ARGOS satellites, using a transmitter developed at the ICM. Data was also stored in the instrument, at 192 samples/day to allow further final global analyses. In the SMOS (Soil Moisture and Ocean Salinity) satellite mission processing chain, sea surface salinity (SSS) values are retrieved from brightness temperature data at level 2 (L2). Global maps of SSS are being generated at level 3 (L3) using spatial and temporal weighted averages. Finally, improved representations of the SSS field are obtained at level 4 (L4) where satellite data is blended with data from other sensors. In the present study, validation of L2, L3 and L4 products using data from BWR and ARGO buoys is presented, covering the race period from January to April 2011. Differences between these two sets of data are also investigated as the uppermost robust measurements from Argo profilers have larger depths than the ones associated to the BWR boat.

  19. Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat.

    Science.gov (United States)

    Martin, Jérôme C; Bériou, Gaëlle; Josien, Régis

    2016-01-01

    Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulfate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs. This section provides with a detailed protocol that we validated in our laboratory to perform DSS-induced acute colitis in the Sprague-Dawley (SPD) rat.

  20. Una aplicación DSS para el mercado del vino

    OpenAIRE

    Martínez Valderrama, Jaime; NIETO, CÉSAR; Martínez Vicente, Joaquín Silvio

    2002-01-01

    El trabajo presenta la estructura y normas de manejo de una aplicación DSS (Sistema de Soporte a la Decisión) para utilizar un modelo de precios hedónicos del vino de calidad y otro del consumo de bebidas alcohólicas en España. El plan del artículo es el siguiente: en primer lugar se presentan, sucesivamente, sendos resúmenes de los trabajos que sirven de soporte a los dos modelos sobre los que se ha construido la aplicación DSS. A continuación, se ofrece l...

  1. 决策支持系统(DSS)的研究与发展%Research and Development of the Decision Supporting System (DSS)

    Institute of Scientific and Technical Information of China (English)

    李珊

    2001-01-01

    分析了决策支持系统(DSS)在计算机管理领域中模型、专用及生成工具、结构、决策风格的研究现状,结合实际论述了DSS群体、智能、分布以及集成化的发展趋向。

  2. A NEW DSS BASED ON INTRANET AND DATA WAREHOUSE%Intranet 环境下基于数据仓库技术的新型DSS

    Institute of Scientific and Technical Information of China (English)

    张华雨; 韩伯棠; 覃云

    2002-01-01

    文中构造了一种Intranet环境下基于数据仓库技术的新型决策支持系统(DSS)的框架,并与传统的DSS进行比较,分析其优势,指出此新型DSS是今后决策支持系统的发展方向.

  3. Analysis of Vertical Dynamics in the Northern Baltic Sea based on 3D Modelling and Data from Shallow-Water Argo Floats

    Science.gov (United States)

    Westerlund, Antti; Tuomi, Laura

    2016-04-01

    Vertical mixing is a challenge for ocean models. 3D hydrodynamic models often produce considerable errors in mixed layer depths and vertical temperature structure that can be related to the vertical turbulence parameterisation. These errors can be pronounced in areas with complex hydrography. In the Baltic Sea, for example, there are high horizontal and vertical salinity gradients. Furthermore, thermocline and halocline are located at different depths. This produces stratification conditions challenging for all ocean models. We studied vertical mixing with modelling experiments and new observational data. NEMO 3D ocean model has been set up at Finnish Meteorological Institute (FMI) for the Baltic Sea, based on the NEMO Nordic configuration. The model has been discretized on a Baltic Sea - North Sea grid with 2 nautical mile resolution and 56 vertical layers, using FMI-HIRLAM atmospheric forcing. The observational data for Baltic Sea off-shore areas is sparse and new methods are needed to collect data for model validation and development. FMI has been testing Argo floats in the Baltic Sea since 2011 in order to increase the amount of observed vertical profiles of salinity and temperature. This is the first time Argo floats have been successfully used in the brackish, shallow waters of the Baltic Sea. This new data set is well suited for evaluating the capability of hydrodynamic models to produce the vertical structure of temperature. It provides a time series of profiles from the area of interest with good temporal resolution, showing the structure of temperature in the water column throughout the summer. We found that NEMO was able to reproduce the general features of the seasonal temperature variations in the study area, when meteorological forcing was accurate. We ran the model with different vertical turbulence parameterisations. The k-ɛ and k-ω schemes showed clear differences, but neither proved superior. While sea surface temperature was better simulated

  4. No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats

    Directory of Open Access Journals (Sweden)

    Gülen Arslan

    2007-01-01

    Full Text Available Background: Omega-3 (n-3 polyunsaturated fatty acids (PUFAs have modulating effects in several chronic inflammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation with n-3 (fish or seal oil or n-6 (soy oil PUFA rich oils would protect the development of dextran sulfate sodium (DSS-induced colitis in rats.Methods: Forty-eight male Wistar rats were divided into 6 groups: no intervention, sham, DSS, seal oil + DSS, fi sh oil +DSS and soy oil + DSS. Following 7 days of acclimatisation, 1 mL oil (seal, fish or soy or distilled water (sham was administered by gavage day 8 to 14. Colitis was induced by 5% DSS in drinking water from day 15 to 21. Rats were sacrificed on day 23. Histological colitis (crypt and inflammation scores, faecal granulocyte marker protein (GMP and quantitative fatty acid composition in red blood cells were measured.Results: Pretreatment with fish or seal oils did not significantly influence DSS induced inflammation. In fact, all the oils tended to exacerbate the inflammation. Soy oil increased the mean crypt score (P < 0.04, but not the inflammation score or GMP. The ratio of n-6 to n-3 fatty acids (FAs was 11 to 1 and 10 to 1 in standard diet and in red blood cells of control rats, respectively. Following administration of DSS, the ratio fell in all treatment groups (P < 0.001. The lowest ratios were seen in the groups receiving DSS + fi sh or seal oils (around 6 to 1.Conclusion: Short-term pretreatment with fish or seal oils did not protect against subsequent induction of colitis by DSS in this rat model. Whether the high ratio of n-6 to n-3 FAs in the standard diet concealed effects of n-3 FA supplementation should be further investigated.

  5. Can DSS Technology Improve Group Decision Performance for End Users?: An Experimental Study.

    Science.gov (United States)

    Gundersen, David E.; And Others

    1995-01-01

    Examines the benefits of Decision Support Systems (DSS) for end-user group decision making. An experiment was conducted which required groups to reach a consensus on human resource-related decisions. The results of the experiment provide implications for the use of group DDS in organizations and for future study. (Author/AEF)

  6. The Contribution of DSS to Limiting Differences in Decisions between Successful and Unsuccessful Teachers

    Science.gov (United States)

    Klein, Joseph

    2007-01-01

    This study examined the contribution of a Decision Support System (DSS) to minimizing differences between the educational decisions of 310 teachers who were classified, according to the teaching skill categories of the NBPTS, as excellent, mediate, or poor. The teachers were asked to analyze the same educational dilemma, once intuitively and a…

  7. Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice.

    Science.gov (United States)

    Håkansson, Å; Tormo-Badia, N; Baridi, A; Xu, J; Molin, G; Hagslätt, M-L; Karlsson, C; Jeppsson, B; Cilio, C M; Ahrné, S

    2015-02-01

    Ulcerative colitis (UC) is characterized by chronic inflammation of the colonic mucosa. Administration of dextran sulfate sodium (DSS) to animals is a frequently used model to mimic human colitis. Deregulation of the immune response to the enteric microflora or pathogens as well as increased intestinal permeability have been proposed as disease-driving mechanisms. To enlarge the understanding of the pathogenesis, we have studied the effect of DSS on the immune system and gut microbiota in mice. Intestinal inflammation was verified through histological evaluation and myeloperoxidase activity. Immunological changes were assessed by flow cytometry in spleen, Peyer's patches and mesenteric lymph nodes and through multiplex cytokine profiling. In addition, quantification of the total amount of bacteria on colonic mucosa as well as the total amount of lactobacilli, Akkermansia, Desulfovibrio and Enterobacteriaceae was performed by the use of quantitative PCR. Diversity and community structure were analysed by terminal restriction fragment length polymorphism (T-RFLP) patterns, and principal component analysis was utilized on immunological and T-RFLP patterns. DSS-induced colitis show clinical and histological similarities to UC. The composition of the colonic microflora was profoundly changed and correlated with several alterations of the immune system. The results demonstrate a relationship between multiple immunological changes and alterations of the gut microbiota after DSS administration. These data highlight and improve the definition of the immunological basis of the disease and suggest a role for dysregulation of the gut microbiota in the pathogenesis of colitis.

  8. A Framework of the Decision Support System (DSS) for Higher Education Appropriate Scale

    Institute of Scientific and Technical Information of China (English)

    ZHAI Li-li; GAO Chang-yuan; HAO Hong-jun

    2002-01-01

    According to the relation of the developing speed and scale of higher education and those of national economy, the establishing method and structure of higher education appropriate scale DSS (HEASDSS) are researched applying to educational economic principle and decision support system theory.

  9. Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair

    DEFF Research Database (Denmark)

    Zhou, Qingwen; Kojic, Milorad; Cao, Zhimin;

    2007-01-01

    Brh2, the BRCA2 ortholog in Ustilago maydis, enables recombinational repair of DNA by controlling Rad51 and is in turn regulated by Dss1. Interplay with Rad51 is conducted via the BRC element located in the N-terminal region of the protein and through an unrelated domain, CRE, at the C terminus...

  10. Afforest sDSS: a metamodel based spatial decision support system for afforestation of agricultural land

    NARCIS (Netherlands)

    Gilliams, S.; Orshoven, van J.; Muys, B.; Kros, J.; Heil, G.W.; Deursen, van W.

    2005-01-01

    The concept and structure of the Spatial Decision Support System AFFOREST sDSS dealing with environmental performance (EP) of afforestation on agricultural land in northwestern Europe, is presented. EP is defined in terms of three environmental impact categories: (1) carbon sequestration (2) groundw

  11. A high resolution salinity time series 1993-2012 in the North Atlantic from Argo and Altimeter data

    Science.gov (United States)

    Stendardo, I.; Rhein, M.; Hollmann, R.

    2016-04-01

    The study of salinity changes has been hampered by the lack of temporal and spatial resolution of the observations. In order to improve the spatial and temporal distribution of salinity observations, we used the Gravest Empirical Mode (GEM) technique to calculate high-resolution salinity distributions as a function of dynamic height for the period 1993-2012. This technique combined Argo and altimeter data to exploit the relationship between T/S profiles and dynamic height in the North Atlantic. The method was valid in the upper 700 m mainly at and near the pathways of the North Atlantic Current (NAC), but failed in regions with weak stratification or with ambiguities in the T/S relationships. Coherent, multiannual large-scale variability was observed, with many features present in all regions, albeit with weaker amplitudes in the eastern basins. Some of the interannual features in the northeastern Atlantic basins were unrelated to the variability further south and west, pointing to an occasional advection of subtropical water in the eastern Atlantic. Origin and advection of salinity anomalies with the NAC from the North American Basin into the western subpolar North Atlantic are correlated with the state of the North Atlantic Oscillation (NAO) and dampened by the surface freshwater fluxes. Other mechanisms influencing the salinity pattern are the changing location of the subpolar front, also related to the NAO. The large multiyear variability in the 20 year time series obscured any potential trends caused by global warming. Only the Rockall Trough showed a salinity increase of 0.03 per decade.

  12. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization.

    Science.gov (United States)

    Lin, Yuli; Yang, Xuguang; Yue, Wenjie; Xu, Xiaofei; Li, Bingji; Zou, Linlin; He, Rui

    2014-07-01

    Chemerin is present in various inflammatory sites and is closely involved in tissue inflammation. Recent studies have demonstrated that chemerin treatment can cause either anti-inflammatory or pro-inflammatory effects according to the disease model being investigated. Elevated circulating chemerin was recently found in patients with inflammatory bowel disease (IBD); however, the role of chemerin in intestinal inflammation remains unknown. In this study, we demonstrated that the administration of exogenous chemerin (aa17-156) aggravated the severity of dextran sulfate sodium (DSS)-induced colitis, which was characterized by higher clinical scores, extensive mucosal damage and significantly increased local and systemic production of pro-inflammatory cytokines, including IL-6, TNF-α and interferon (IFN-γ). Interestingly, chemerin did not appear to influence the magnitudes of inflammatory infiltrates in the colons, but did result in significantly decreased colonic expression of M2 macrophage-associated genes, including Arginase 1 (Arg-1), Ym1, FIZZ1 and IL-10, following DSS exposure, suggesting an impaired M2 macrophage skewing in vivo. Furthermore, an in vitro experiment showed that the addition of chemerin directly suppressed M2 macrophage-associated gene expression and STAT6 phosphorylation in IL-4-stimulated macrophages. Significantly elevated chemerin levels were found in colons from DSS-exposed mice and from ulcerative colitis (UC) patients and appeared to positively correlate with disease severity. Moreover, the in vivo administration of neutralizing anti-chemerin antibody significantly improved intestinal inflammation following DSS exposure. Taken together, our findings reveal a pro-inflammatory role for chemerin in DSS-induced colitis and the ability of chemerin to suppress the anti-inflammatory M2 macrophage response. Our study also suggests that upregulated chemerin in inflamed colons may contribute to the pathogenesis of IBD.

  13. CD137 Facilitates the Resolution of Acute DSS-Induced Colonic Inflammation in Mice

    Science.gov (United States)

    Martínez Gómez, Julia M.; Chen, Lieping; Schwarz, Herbert; Karrasch, Thomas

    2013-01-01

    Background CD137 and its ligand (CD137L) are potent immunoregulatory molecules that influence activation, proliferation, differentiation and cell death of leukocytes. Expression of CD137 is upregulated in the lamina propria cells of Crohn’s disease patients. Here, the role of CD137 in acute Dextran-Sodium-Sulfate (DSS)-induced colitis in mice was examined. Methods We induced acute large bowel inflammation (colitis) via DSS administration in CD137−/− and wild-type (WT) mice. Colitis severity was evaluated by clinical parameters (weight loss), cytokine secretion in colon segment cultures, and scoring of histological inflammatory parameters. Additionally, populations of lamina propria mononuclear cells (LPMNC) and intraepithelial lymphocytes (IEL) were characterized by flow cytometry. In a subset of mice, resolution of intestinal inflammation was evaluated 3 and 7 days after withdrawal of DSS. Results We found that both CD137−/− and WT mice demonstrated a similar degree of inflammation after 5 days of DSS exposure. However, the resolution of colonic inflammation was impaired in the absence of CD137. This was accompanied by a higher histological score of inflammation, and increased release of the pro-inflammatory mediators granulocyte macrophage colony-stimulating factor (GM-CSF), CXCL1, IL-17 and IFN-γ. Further, there were significantly more neutrophils among the LPMNC of CD137−/− mice, and reduced numbers of macrophages among the IEL. Conclusion We conclude that CD137 plays an essential role in the resolution of acute DSS-induced intestinal inflammation in mice. PMID:24023849

  14. Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis

    Science.gov (United States)

    Kanda, Toshihiro; Ohno, Masashi; Imaeda, Hirotsugu; Shimada, Takashi; Inatomi, Osamu; Bamba, Shigeki; Sugimoto, Mitsushige; Andoh, Akira

    2016-01-01

    Background and Aims Probiotic properties of Enterococcus strains have been reported previously. In this study, we investigated the effects of Enterococcus (E.) durans TN-3 on the development of dextran sulfate sodium (DSS) colitis. Methods BALB/c mice were fed with 4.0% DSS in normal chow. Administration of TN-3 (10mg/day) was initiated 7days before the start of DSS feeding. Mucosal cytokine expression was analyzed by real time-PCR and immunohistochemistry. The lymphocyte subpopulation were analyzed by flow cytometry. The gut microbiota profile was analyzed by a terminal-restriction fragment length polymorphism method (T-RFLP). Results The disease activity index and histological colitis score were significantly lower in the DSS plus TN-3 group than in the DSS group. The mucosal mRNA expression of proinflammatory cytokines (IL-1β, IL-6, IL-17A and IFN-γ) decreased significantly in the DSS plus TN-3 group as compared to the DSS group. The proportion of regulatory T cells (Treg cells) in the mucosa increased significantly in the DSS plus TN-3 group as compared to the DSS group. Both fecal butyrate levels and the diversity of fecal microbial community were significantly higher in the TN-3 plus DSS group than in the DSS group. Conclusions E. durans TN-3 exerted an inhibitory effect on the development of DSS colitis. This action might be mediated by the induction of Treg cells and the restoration of the diversity of the gut microbiota. PMID:27438072

  15. Estimating the global oceanic net freshwater flux from Argo and comparing it with satellite-based freshwater flux products

    Science.gov (United States)

    Ren, Li; Hackert, Eric; Arkin, Phillip; Busalacchi, Antonio J.

    2014-11-01

    Following the idea that analysis of in situ information in the salt budget could be used as a surrogate for global "ocean rain gauge," the annual mean oceanic net freshwater flux (E-P) was estimated from the Argo profiles and the wind stress data on a global scale. The comparison between the independent E-P estimation from Argo and the E-P product sets, including the combination of precipitation from TRMM, GPCP, CMAP and evaporation from OAFlux, GSSTF3 and IFREMER and E-P set from NEWS formed from satellite, generally show similar spatial patterns, particularly on the large scale. However, there are differences among the different satellite-based E-P estimates and between satellite estimates and independent in situ estimates. Based on the pattern correlation and the RMSD, the evaporation and precipitation from OAFlux and TRMM agrees best with the E-P estimated from the independent Argo-based estimates.

  16. Evaluation of Argos Telemetry Accuracy in the High-Arctic and Implications for the Estimation of Home-Range Size.

    Directory of Open Access Journals (Sweden)

    Sylvain Christin

    Full Text Available Animal tracking through Argos satellite telemetry has enormous potential to test hypotheses in animal behavior, evolutionary ecology, or conservation biology. Yet the applicability of this technique cannot be fully assessed because no clear picture exists as to the conditions influencing the accuracy of Argos locations. Latitude, type of environment, and transmitter movement are among the main candidate factors affecting accuracy. A posteriori data filtering can remove "bad" locations, but again testing is still needed to refine filters. First, we evaluate experimentally the accuracy of Argos locations in a polar terrestrial environment (Nunavut, Canada, with both static and mobile transmitters transported by humans and coupled to GPS transmitters. We report static errors among the lowest published. However, the 68th error percentiles of mobile transmitters were 1.7 to 3.8 times greater than those of static transmitters. Second, we test how different filtering methods influence the quality of Argos location datasets. Accuracy of location datasets was best improved when filtering in locations of the best classes (LC3 and 2, while the Douglas Argos filter and a homemade speed filter yielded similar performance while retaining more locations. All filters effectively reduced the 68th error percentiles. Finally, we assess how location error impacted, at six spatial scales, two common estimators of home-range size (a proxy of animal space use behavior synthetizing movements, the minimum convex polygon and the fixed kernel estimator. Location error led to a sometimes dramatic overestimation of home-range size, especially at very local scales. We conclude that Argos telemetry is appropriate to study medium-size terrestrial animals in polar environments, but recommend that location errors are always measured and evaluated against research hypotheses, and that data are always filtered before analysis. How movement speed of transmitters affects location

  17. Evaluation of Argos Telemetry Accuracy in the High-Arctic and Implications for the Estimation of Home-Range Size.

    Science.gov (United States)

    Christin, Sylvain; St-Laurent, Martin-Hugues; Berteaux, Dominique

    2015-01-01

    Animal tracking through Argos satellite telemetry has enormous potential to test hypotheses in animal behavior, evolutionary ecology, or conservation biology. Yet the applicability of this technique cannot be fully assessed because no clear picture exists as to the conditions influencing the accuracy of Argos locations. Latitude, type of environment, and transmitter movement are among the main candidate factors affecting accuracy. A posteriori data filtering can remove "bad" locations, but again testing is still needed to refine filters. First, we evaluate experimentally the accuracy of Argos locations in a polar terrestrial environment (Nunavut, Canada), with both static and mobile transmitters transported by humans and coupled to GPS transmitters. We report static errors among the lowest published. However, the 68th error percentiles of mobile transmitters were 1.7 to 3.8 times greater than those of static transmitters. Second, we test how different filtering methods influence the quality of Argos location datasets. Accuracy of location datasets was best improved when filtering in locations of the best classes (LC3 and 2), while the Douglas Argos filter and a homemade speed filter yielded similar performance while retaining more locations. All filters effectively reduced the 68th error percentiles. Finally, we assess how location error impacted, at six spatial scales, two common estimators of home-range size (a proxy of animal space use behavior synthetizing movements), the minimum convex polygon and the fixed kernel estimator. Location error led to a sometimes dramatic overestimation of home-range size, especially at very local scales. We conclude that Argos telemetry is appropriate to study medium-size terrestrial animals in polar environments, but recommend that location errors are always measured and evaluated against research hypotheses, and that data are always filtered before analysis. How movement speed of transmitters affects location error needs

  18. An argo-based model for investigation of the Global Ocean (AMIGO)

    Science.gov (United States)

    Lebedev, K. V.

    2016-03-01

    We analyze the newly developed Argo-Based Model for Investigation of the Global Ocean (AMIGO), which consists of a block for variational interpolation of the profiles of drifting Argo floats to a regular grid and a block for model hydrodynamic adjustment of variationally interpolated fields. Such a method makes it possible to obtain a full set of oceanographic characteristics—temperature, salinity, density, and current velocity—using irregularly located Argo measurements. The resulting simulations are represented as monthly mean, seasonal, and annual means and climatological fields. The AMIGO oceanographic database developed at the Shirshov Institute of Oceanology from model simulations covers the 10-year period from 2005 to 2014. Analysis of transport variations in the propagation of North Atlantic Current jets to the Arctic based on the AMIGO data showed that during this period, anomalous winter transports were observed, which correlate with anomalous winter temperatures in regions of northwestern Europe, northern European Russia, and Iceland, which are subjected to the influence of these currents. Comparative analysis of variations in mass and heat transport by the currents and the North Atlantic Oscillation (NAO) index in the period of 2005-2014 shows a well pronounced correlation between them. The low winter values of the NAO index correspond to the low values of winter transports by the Faroe-Shetland branch of the North Atlantic current, and usually, to the high values of winter transports by the North Icelandic branch of the Irminger Current. High winter value of the NAO index results in a substantial increase in the winter transport by the Faroe-Shetland branch of the North Atlantic Current without notable influence on the transport of the North Icelandic branch of the Irminger Current.

  19. Circumpolar Estimates of Isopycnal Mixing in the ACC from Argo Floats

    Science.gov (United States)

    Roach, C. J.; Balwada, D.; Speer, K. G.

    2015-12-01

    There are few direct observations of cross-stream isopycnal mixing in the interior of the Southern Ocean, yet such measurements are needed to determine the role of eddies transporting properties across the ACC, and key to progress toward testing theories of meridional overturning. In light of this we examine if it is possible to obtain estimates of mixing from Argo float trajectories. We divided the Southern Ocean into overlapping 15ο longitude bins before estimating mixing. Resulting diffusivities ranged from 300 to 3000 m2s-1, with peaks corresponding to the Scotia Sea; Kerguelen and Campbell Plateaus. Comparison of our diffusivities with previous regional studies demonstrated good agreement. Tests of the methodology in the DIMES region found that mixing from Argo floats agreed closely with mixing from RAFOS floats. To further test the method we used the Southern Ocean State Estimate velocity fields to advect particles with Argo and RAFOS float like behaviours. Stirring estimates from the particles agreed well with each other in the Kerguelen Island region, South Pacific and Scotia Sea, despite the differences in the imposed behaviour. Finally, these estimates were compared to mixing length suppression theory presented in Ferrari and Nikurashin 2010. This mixing length suppression theory quantifies horizontal diffusivity similar to Prandtl (1925), but the mixing length is suppressed in the presence of mean flows and eddy phase speeds. Our results suggest that the theory can explain both the structure and magnitude of mixing using mean flow data. An exception is near the Kerguelen and Campbell Plateaus where theory under-estimates mixing relative to our results.

  20. The ARGOS laser system: green light for ground layer adaptive optics at the LBT

    Science.gov (United States)

    Raab, Walfried; Rabien, Sebastian; Gässler, Wolfgang; Esposito, Simone; Barl, Lothar; Borelli, Jose; Daysenroth, Matthias; Gemperlein, Hans; Kulas, Martin; Ziegleder, Julian

    2014-07-01

    We report on the development of the laser system of ARGOS, the multiple laser guide star adaptive optics system for the Large Binocular Telescope (LBT). The system uses a total of six high powered, pulsed Nd:YAG lasers frequency-doubled to a wavelength of 532 nm to generate a set of three guide stars above each of the LBT telescopes. The position of each of the LGS constellations on sky as well as the relative position of the individual laser guide stars within this constellation is controlled by a set of steerable mirrors and a fast tip-tilt mirror within the laser system. The entire opto-mechanical system is housed in two hermetically sealed and thermally controlled enclosures on the SX and DX side of the LBT telescope. The laser beams are propagated through two refractive launch telescopes which focus the beams at an altitude of 12 km, creating a constellation of laser guide stars around a 4 arcminute diameter circle by means of Rayleigh scattering. In addition to the GLAO Rayleigh beacon system, ARGOS has also been designed for a possible future upgrade with a hybrid sodium laser - Rayleigh beacon combination, enabling diffraction limited operation. The ARGOS laser system was successfully installed at the LBT in April 2013. Extensive functional tests have been carried out and have verified the operation of the systems according to specifications. The alignment of the laser system with respect to the launch telescope was carried out during two more runs in June and October 2013, followed by the first propagation of laser light on sky in November 2013.

  1. Argo data assimilation into HYCOM with an EnOI method in the Atlantic Ocean

    Directory of Open Access Journals (Sweden)

    D. Mignac

    2014-07-01

    Full Text Available An ocean data assimilation system to assimilate Argo temperature (T and salinity (S profiles into HYCOM was constructed, implemented and evaluated for the first time in the Atlantic Ocean (78° S to 50° N and 98° W to 20° E. The system is based on the Ensemble Optimal Interpolation (EnOI algorithm proposed by Xie and Zhu (2010, especially made to deal with the hybrid nature of HYCOM vertical coordinate system with multiple steps. The Argo T/S profiles were projected to the model vertical space to create pseudo-observed layer thicknesses (Δ pobs which correspond to the model target densities. The first step was to assimilate Δ pobs considering the sub-state vector composed by the model layer thickness (Δ p and the baroclinic velocity components. After that, T and S were assimilated separately. At last, T was diagnosed below the mixed layer to preserve the density of the model isopycnal layers. Five experiments were performed from 1 January 2010 until 31 December 2012: a control run without assimilation, and four assimilation runs considering different vertical localizations of T, S and Δ p. The assimilation experiments were able to significantly improve the thermohaline structure produced by the control run. They reduced the RMSD of T (S calculated with respect to Argo independent data in 34.11% (43.56% in comparison to the control run. In some regions, such as the west North Atlantic, substantial corrections in the 20 °C isotherm depth and the upper ocean heat content towards climatological states were achieved. The runs with vertical localization of Δ p showed positive impacts in the correction of the thermohaline structure and reduced the RMSD of T (S from 0.993 °C (0.149 psu to 0.905 °C (0.138 psu for the whole domain with respect to the other assimilation runs.

  2. Interpolation of On-Line Data of the Argo Float System for Data Assimilation in the World Ocean Circulation Model

    Science.gov (United States)

    Zakharova, N. B.; Lebedev, S. A.

    2010-12-01

    For many years parameters of the World ocean state were measured by traditional contact methods that lacked in efficiency and the ability to measure temperature much beneath the surface. The ARGO float system involves both contact and distance ocean parameters measure methods. Sea temperature and salinity profiles are measured by contact methods, but data communication is made using satellites. Therefore, the ARGO float system has added efficiency and greater reliability to ocean parameters measurements. Interpolation and extrapolation methods of input information are important among numerical mathematical methods used for solving data assimilation problems. Thus the development of such algorithms and programs based on up-to-date approaches is a timely problem.

  3. Virtual Visit to the ATLAS Control Room by High schools of Argos prefecture

    CERN Multimedia

    2014-01-01

    Continuing the subatomic journey that started last year in Argos, Greece, 45 students from 14 high schools of the prefecture will take part in a dedicated ATLAS Masterclass organized by the University of Athens in the framework of the Go-Lab and Inspiring Science Education European projects. Students will learn how to analyse real events from the ATLAS experiment with the use of HYPATIA online applet. They will also have the opportunity to visit the ATLAS control room to learn what it takes for scientists to keep on pushing the boundaries of our understanding of the origins of the universe.

  4. Mean Interplanetary Magnetic Field Measurement Using the ARGO-YBJ Experiment

    CERN Document Server

    Aielli, G; Bartoli, B; Bernardini, P; Bi, X J; Bleve, C; Branchini, P; Budano, A; Bussino, S; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cappa, A; Cardarelli, R; Catalanotti, S; Cattaneo, C; Celio, P; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; De Vincenzi, M; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Z Y; Feng, Zhenyong; Galeazzi, F; Galeotti, P; Gargana, R; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liberti, B; Liguori, G; Liu, C; Liu, C Q; Liu, M Y; Liu, J; Lu, H; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Meng, X R; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Perrone, L; Pistilli, P; Qu, X B; Rossi, E; Ruggieri, F; Saggese, L; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Yao, Z G; Xu, B; Xue, L; Yan, Y X; Yang, Q Y; Yang, X C; Yuan, A F; Zha, M; Zhang, H M; Zhang, JiLong; Zhang, JianLi; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhaxisangzhu,; Zhaxiciren,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2011-01-01

    The sun blocks cosmic ray particles from outside the solar system, forming a detectable shadow in the sky map of cosmic rays detected by the ARGO-YBJ experiment in Tibet. Because the cosmic ray particles are positive charged, the magnetic field between the sun and the earth deflects them from straight trajectories and results in a shift of the shadow from the true location of the sun. Here we show that the shift measures the intensity of the field which is transported by the solar wind from the sun to the earth.

  5. Spatial correlations applied to gamma/hadron discrimination in the ARGO-YBJ experiment

    International Nuclear Information System (INIS)

    Following recently proposed approaches on gamma/hadron separation, spatial correlations among secondary charged particles in extensive air showers have been studied for the case of the ARGO-YBJ experiment, which represents a particularly suited detector in this respect because of its “continuous-carpet” geometry. Two different types of statistics have been considered, namely the nearest-neighbor spacing distribution (NNSD) and the variance of the number of secondary particles at given distance. The results of this preliminary investigation are reported

  6. Recent Results from ArgoNeuT and Status of MicroBooNE

    Energy Technology Data Exchange (ETDEWEB)

    Szelc, Andrzej [Yale

    2015-07-10

    Liquid Argon Time Projection Chamber (LArTPC) detectors hold the key to answering the outstanding questions about the role of neutrinos in the Standard Model of Particle physics and beyond. Their fine granularity combined with calorimetric capabilities allows for precision measurements that answering these questions will require. Here, we discuss the recent results from the ArgoNeuT experiment as well as the status and prospects for MicroBooNE, both a part of the US-based LArTPC neutrino program.

  7. Dried Saliva Spot (DSS) as a Convenient and Reliable Sampling for Bioanalysis: An Application for the Diagnosis of Diabetes Mellitus.

    Science.gov (United States)

    Numako, Masahiro; Takayama, Takahiro; Noge, Ichiro; Kitagawa, Yutaka; Todoroki, Kenichiro; Mizuno, Hajime; Min, Jun Zhe; Toyo'oka, Toshimasa

    2016-01-01

    This paper proposes the dried saliva spot (DSS) as a convenient sampling technique for bioanalysis. The analytical method with the DSS was used for the determination of D,L-lactic acid (D,L-LA) and the D/L ratio of diabetic patients and prediabetic persons for the simple screening of the disease. The D,L-LA in the DSS was labeled with a chiral reagent (DMT-3(S)-Apy) for carboxylic acids and determined by UPLC-ESI-MS/MS. The limits of detection (signal-to-noise ratio (S/N) = 3) for the DSS analysis were on the amol level (∼30 amol). Because good stability, recovery, accuracy, and precision of the D,L-LA for the DSS method was also obtained from the proposed procedure, the DSS method was applied to the determination of the D- and L-isomers of LA of diabetic patients, and prediabetic and healthy persons. The D/L-LA ratio by the present DSS method and the HbA1c value in blood were well-correlated to the serious diabetic patients, whereas the relation in the prediabetic persons was not very good. The reason seems to be due to the rough saliva sampling, and not to the DSS method, because strict regulation was not requested for the prediabetic and healthy persons. In order to have a successful DSS analysis, the stability of the target molecule, the detection sensitivity to the target molecule, and the validated determination method are important.

  8. DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model.

    Science.gov (United States)

    Achiwa, Koichi; Ishigami, Masatoshi; Ishizu, Yoji; Kuzuya, Teiji; Honda, Takashi; Hayashi, Kazuhiko; Hirooka, Yoshiki; Katano, Yoshiaki; Goto, Hidemi

    2016-01-29

    Nonalcoholic steatohepatitis (NASH) patients progress to liver cirrhosis and even hepatocellular carcinoma (HCC). Several lines of evidence indicate that accumulation of lipopolysaccharide (LPS) and disruption of gut microbiota play contributory roles in HCC. Moreover, in a dextran sodium sulfate (DSS)-induced colitis model in mice, a high-fat diet increases portal LPS level and promotes hepatic inflammation and fibrosis. However, this diet-induced NASH model requires at least 50 weeks for carcinogenesis. In this study, we sought to determine whether increased intestinal permeability would aggravate liver inflammation and fibrosis and accelerate tumorigenesis in a diet-induced NASH model. Mice were fed a choline-deficient high-fat (CDHF) diet for 4 or 12 weeks. The DSS group was fed CDHF and intermittently received 1% DSS in the drinking water. Exposure to DSS promoted mucosal changes such as crypt loss and increased the number of inflammatory cells in the colon. In the DSS group, portal LPS levels were elevated at 4 weeks, and the proportions of Clostridium cluster XI in the fecal microbiota were elevated. In addition, levels of serum transaminase, number of lobular inflammatory cells, F4/80 staining-positive area, and levels of inflammatory cytokines were all elevated in the DSS group. Liver histology in the DSS group revealed severe fibrosis at 12 weeks. Liver tumors were detected in the DSS group at 12 weeks, but not in the other groups. Thus, DSS administration promoted liver tumors in a CDHF diet-induced NASH mouse over the short term, suggesting that the induction of intestinal inflammation and gut disruption of microbiota in NASH promote hepatic tumorigenesis.

  9. Dried Saliva Spot (DSS) as a Convenient and Reliable Sampling for Bioanalysis: An Application for the Diagnosis of Diabetes Mellitus.

    Science.gov (United States)

    Numako, Masahiro; Takayama, Takahiro; Noge, Ichiro; Kitagawa, Yutaka; Todoroki, Kenichiro; Mizuno, Hajime; Min, Jun Zhe; Toyo'oka, Toshimasa

    2016-01-01

    This paper proposes the dried saliva spot (DSS) as a convenient sampling technique for bioanalysis. The analytical method with the DSS was used for the determination of D,L-lactic acid (D,L-LA) and the D/L ratio of diabetic patients and prediabetic persons for the simple screening of the disease. The D,L-LA in the DSS was labeled with a chiral reagent (DMT-3(S)-Apy) for carboxylic acids and determined by UPLC-ESI-MS/MS. The limits of detection (signal-to-noise ratio (S/N) = 3) for the DSS analysis were on the amol level (∼30 amol). Because good stability, recovery, accuracy, and precision of the D,L-LA for the DSS method was also obtained from the proposed procedure, the DSS method was applied to the determination of the D- and L-isomers of LA of diabetic patients, and prediabetic and healthy persons. The D/L-LA ratio by the present DSS method and the HbA1c value in blood were well-correlated to the serious diabetic patients, whereas the relation in the prediabetic persons was not very good. The reason seems to be due to the rough saliva sampling, and not to the DSS method, because strict regulation was not requested for the prediabetic and healthy persons. In order to have a successful DSS analysis, the stability of the target molecule, the detection sensitivity to the target molecule, and the validated determination method are important. PMID:26629726

  10. New methods to measure and model logistics and goods effects by the use of the CLG-DSS Model

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Jensen, Anders Vestergaard

    2004-01-01

    This paper concerns the assessment and modelling of so-called logistics and goods effects (LG-effects) as part of a wider economic analysis by use of the developed CLG-DSS model. The results presented are based an on-going study, Task 9 about evaluation modelling and decision support systems (DSS...... The aim of this paper is to present these four LG-effects with a special emphasis on a possible way of modelling these and interpreting their importance. The calculations are carried out by using the CLG-DSS model and case studies concerning the fixed links across the Great Belt and Øresund...

  11. Pre-shipment test of the ARGOS laser guide star wavefront sensor

    Science.gov (United States)

    Bonaglia, Marco; Busoni, Lorenzo; Mazzoni, Tommaso; Puglisi, Alfio; Antichi, Jacopo; Esposito, Simone; Orban de Xivry, Gilles; Rabien, Sebastian

    2014-08-01

    We present the results of the laboratory characterization of the ARGOS LGS wavefront sensor (LGSW) and dichroic units. ARGOS is the laser guide star adaptive optics system of the Large Binocular Telescope (LBT). It implements a Ground Layer Adaptive Optics (GLAO) correction for LUCI, an infrared imager and multi-object spectrograph (MOS), using 3 pulsed Rayleigh beacons focused at 12km altitude. The LGSW is a Shack-Hartman sensor having 15 × 15 subaspertures over the telescope pupil. Each LGS is independently stabilized for on-sky jitter and gated to reduce spot elongation. The 3 LGS pupils are stabilized to compensate mechanical flexure and are arranged on a single detector. Two units of LGSW have been produced and tested at Arcetri Observatory. We report on the results obtained in the pre-shipment laboratory test: internal active flexure compensation loop performance, optomechanical stability under different gravity conditions, thermal cycling, Pockels cells performance. We also update on the upcoming installation and commissioning campaign at LBT.

  12. A calibration method of Argo floats based on multiple regression analysis

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Argo floats are free-moving floats that report vertical profiles of salinity, temperature and pressure at regular time intervals. These floats give good measurements of temperature and pressure, but salinity measurements may show significant sensor drifting with time. It is found that sensor drifting with time is not purely linear as presupposed by Wong (2003). A new method is developed to calibrate conductivity data measured by Argo floats. In this method, Wong's objective analysis method was adopted to estimate the background climatological salinity field on potential temperature surfaces from nearby historical data in WOD01. Furthermore, temperature and time factors are taken into account, and stepwise regression was used for a time-varying or temperature-varying slope in potential conductivity space to correct the drifting in these profiling float salinity data. The result shows salinity errors using this method are smaller than that of Wong's method, the quantitative and qualitative analysis of the conductivity sensor can be carried out with our method.

  13. The analog Resistive Plate Chamber detector of the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari1, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini1, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q

    2015-01-01

    The ARGO-YBJ experiment has been in stable data taking from November 2007 till February 2013 at the YangBaJing Cosmic Ray Observatory (4300 m a.s.l.). The detector consists of a single layer of Resistive Plate Chambers (RPCs) ( about 6700 m^2}) operated in streamer mode. The signal pick-up is obtained by means of strips facing one side of the gas volume. The digital readout of the signals, while allows a high space-time resolution in the shower front reconstruction, limits the measurable energy to a few hundred TeV. In order to fully investigate the 1-10 PeV region, an analog readout has been implemented by instrumenting each RPC with two large size electrodes facing the other side of the gas volume. Since December 2009 the RPC charge readout has been in operation on the entire central carpet (about 5800 m^2). In this configuration the detector is able to measure the particle density at the core position where it ranges from tens to many thousands of particles per m^2. Thus ARGO-YBJ provides a highly detailed...

  14. Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model.

    Science.gov (United States)

    Huo, Xiaowei; Liu, Dongyu; Gao, Li; Li, Liyong; Cao, Li

    2016-08-24

    Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated carcinogenesis (CAC). Thus, it is well accepted that ameliorating inflammation creates a potential to achieve an inhibitory effect on CAC. Licorice flavonoids (LFs) possess strong anti-inflammatory activity, making it possible to investigate its pharmacologic role in suppressing CAC. The purpose of the present study was to evaluate the anti-tumor potential of LFs, and further explore the underlying mechanisms. Firstly, an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mouse model was established and administered with or without LFs for 10 weeks, and then the severity of CAC was examined macroscopically and histologically. Subsequently, the effects of LFs on expression of proteins associated with apoptosis and proliferation, levels of inflammatory cytokine, expression of phosphorylated-Janus kinases 2 (p-Jak2) and phosphorylated-signal transducer and activator of transcription 3 (p-Stat3), and activation of nuclear factor-κB (NFκB) and P53 were assessed. We found that LFs could significantly reduce tumorigenesis induced by AOM/DSS. Further study revealed that LFs treatment substantially reduced activation of NFκB and P53, and subsequently suppressed production of inflammatory cytokines and phosphorylation of Jak2 and Stat3 in AOM/DSS-induced mice. Taken together, LFs treatment alleviated AOM/DSS induced CAC via P53 and NFκB/IL-6/Jak2/Stat3 pathways, highlighting the potential of LFs in preventing CAC.

  15. Evaluation of Concrete Consolidation: DSS-35 Antenna Reinforced Concrete Pedestal, Canberra Deep Space Communications Complex, Australia

    Science.gov (United States)

    Saldua, B. P.; Dodge, E. C.; Kolf, P. R.; Olson, C. A.

    2016-02-01

    Antenna structures for the Deep Space Network track spacecraft that are millions of miles away. Therefore, these structures have tight specifications for translation, rotation, and differential settlement. This article presents several nondestructive test methods that were used to evaluate, locate, and repair imperfections in the reinforced concrete pedestal that supports the DSS-35 antenna structure. These methods include: (1) impulse response (IR), (2) ultrasonic shear-wave tomography (MIRA), and (3) ground-penetrating radar (GPR).

  16. A Web-based Intelligentized DSS Model for Manufacture and Management

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This article discusses and realizes an intelligentized DSS model for manufacture and management under Intranet environment. It takes the advantage of Web techniques to integrate data and symbolic processing and forms a uniformedf ramework based on information management through the invocation of sub-systems. The model provides user a supporting environment for the management decision-making of enterprises by qualitative deduction and quantitative calculation.

  17. Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model.

    Science.gov (United States)

    Huo, Xiaowei; Liu, Dongyu; Gao, Li; Li, Liyong; Cao, Li

    2016-01-01

    Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated carcinogenesis (CAC). Thus, it is well accepted that ameliorating inflammation creates a potential to achieve an inhibitory effect on CAC. Licorice flavonoids (LFs) possess strong anti-inflammatory activity, making it possible to investigate its pharmacologic role in suppressing CAC. The purpose of the present study was to evaluate the anti-tumor potential of LFs, and further explore the underlying mechanisms. Firstly, an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mouse model was established and administered with or without LFs for 10 weeks, and then the severity of CAC was examined macroscopically and histologically. Subsequently, the effects of LFs on expression of proteins associated with apoptosis and proliferation, levels of inflammatory cytokine, expression of phosphorylated-Janus kinases 2 (p-Jak2) and phosphorylated-signal transducer and activator of transcription 3 (p-Stat3), and activation of nuclear factor-κB (NFκB) and P53 were assessed. We found that LFs could significantly reduce tumorigenesis induced by AOM/DSS. Further study revealed that LFs treatment substantially reduced activation of NFκB and P53, and subsequently suppressed production of inflammatory cytokines and phosphorylation of Jak2 and Stat3 in AOM/DSS-induced mice. Taken together, LFs treatment alleviated AOM/DSS induced CAC via P53 and NFκB/IL-6/Jak2/Stat3 pathways, highlighting the potential of LFs in preventing CAC. PMID:27563884

  18. From satellite altimetry to operational oceanography and Argo: three revolutions in oceanography (Fridtjof Nansen Medal Lecture)

    Science.gov (United States)

    Le Traon, P. Y.

    2012-04-01

    The launch of the US/French mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large scale sea level and ocean circulation observations was flying. Topex/Poseidon revolutionized our vision and understanding of the ocean. It provided new views of the large scale seasonal and interannual sea level and ocean circulation variations. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. The ERS-1/2 orbit was well adapted for mesoscale circulation sampling but the orbit determination and altimeter performance were much less precise than for T/P. We demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. This was an essential first step for the merging of T/P and ERS-1/2. The second step required the development of a global optimal interpolation method. Near real time high resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 years. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. The unique capability of satellite altimetry to observe the global ocean in near real time at high resolution was essential to the development of global ocean forecasting, a second revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) (1998-2008) was phased with the T/P and ERS-1/2 successors (Jason-1 and ENVISAT) and was instrumental in the development of global operational oceanography capabilities. Europe played a leading role in GODAE. In 1998, the global in-situ observing system was inadequate for the global scope of GODAE. This led to the development of Argo, an

  19. An integrated information management system based DSS for problem solving and decision making in open & distance learning institutions of India

    Directory of Open Access Journals (Sweden)

    Pankaj Khanna

    2014-04-01

    Full Text Available An integrated information system based DSS is developed for Open and Distance Learning (ODL institutions in India. The system has been web structured with the most suitable newly developed modules. A DSS model has been developed for solving semi-structured and unstructured problems including decision making with regard to various programmes and activities operating in the ODLIs. The DSS model designed for problem solving is generally based on quantitative formulas, whereas for problems involving imprecision and uncertainty, a fuzzy theory based DSS is employed. The computer operated system thus developed would help the ODLI management to quickly identify programmes and activities that require immediate attention. It shall also provide guidance for obtaining the most appropriate managerial decisions without any loss of time. As a result, the various subsystems operating in the ODLI are able to administer its activities more efficiently and effectively to enhance the overall performance of the concerned ODL institution to a new level.

  20. 登陆作战辅助决策系统%DSS for Landing Battle

    Institute of Scientific and Technical Information of China (English)

    袁小虎; 刘典斗; 何友金

    2009-01-01

    Owe to mercurial air-sea environment during landing battles, decision support system (DSS) has become a necessary method for the validity and time utility of landing battle's decision-making. Analyzed the requirements of landing battle to DSS of air-sea environment, and ensured the system structure based on date base, model base and man-machine interface. Lastly, DSS was adopted based on improved BP neural network technology decision-making method, and the system runned well and has made good decision-making effects.%登陆作战中的大气海洋环境复杂多样,其必须借助辅助决策手段保证决策的正确性和时效性.分析登陆作战对大气海洋环境辅助决策的需求,确定基于数据库、模型库和人机界面的系统结构.最后,开发采用基于改进BP神经网络技术决策方法的辅助决策系统,该系统运行良好,能取得较好的决策效果.

  1. Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.

    Science.gov (United States)

    Jiang, Xingwei; Yu, Jiahui; Shi, Qingzhu; Xiao, Yan; Wang, Wei; Chen, Guojiang; Zhao, Zhi; Wang, Renxi; Xiao, He; Hou, Chunmei; Feng, Jiannan; Ma, Yuanfang; Shen, Beifen; Wang, Lili; Li, Yan; Han, Gencheng

    2015-10-01

    Tim-3 is involved in the physiopathology of inflammatory bowel disease (IBD), but the underlying mechanism is unknown. Here, we demonstrated that, in mouse with DSS colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Adoptive transfer of Tim-3-silenced macrophages worsened DSS colitis and enhanced inflammation, while Tim-3 overexpression attenuated DSS colitis by decreasing the M1 macrophage response. Co-culture of Tim-3-overexpressing macrophages with intestinal lymphocytes decreased the pro-inflammatory response. Tim-3 shaped intestinal macrophage polarization may be TLR-4 dependent since Tim-3 blockade failed to exacerbate colitis or increase M1 macrophage response in the TLR-4 KO model. Finally, Tim-3 signaling inhibited phosphorylation of IRF3, a TLR-4 downstream transcriptional factor regulating macrophage polarization. A better understanding of this pathway may shed new light on colitis pathogenesis and result in a new therapeutic strategy.

  2. A New High-Frequency Search for Galactic Center Millisecond Pulsars using DSS-43

    Science.gov (United States)

    Lemley, Cameron; Prince, Thomas Allen; Majid, Walid A.; Murchikova, Elena

    2016-01-01

    The primary 70-meter Deep Space Network antenna (DSS-43) in Canberra, Australia was equipped with a new high-frequency (18-28 GHz) receiver system in May 2015 for use in a search for Galactic Center (GC) millisecond pulsars. The primary motivation for this search is that a pulsar in the Galactic Center region (especially one that is gravitationally bound to the massive black hole at the GC) would provide unprecedented tests of gravity in the strong-field regime and would offer an entirely new tool for probing the characteristics of the Galactic Center region. Preparation for the GC pulsar search has involved the development of a single-pulse search pipeline that integrates tools from both Fortran and Python as well as the implementation of this pipeline on high performance CPUs. The original version of the search pipeline was developed using Vela Pulsar data from DSS-43, and a more refined version that relies upon chi-squared fitting techniques was ultimately developed using Crab Pulsar data. Future work will involve continued testing of the single-pulse search pipeline using data from the rotating radio transient (RRAT) J1819-1458, the characterization of RRAT pulses using high time resolution data from the new receiver system on DSS-43, and ultimately the analysis of high-frequency data using the existing pipeline to search for millisecond pulsars in the Galactic Center.

  3. To Make Good Decision: A Group DSS for Multiple Criteria Alternative Rank and Selection

    Directory of Open Access Journals (Sweden)

    Chen-Shu Wang

    2015-01-01

    Full Text Available Decision making is a recursive process and usually involves multiple decision criteria. However, such multiple criteria decision making may have a problem in which partial decision criteria may conflict with each other. An information technology, such as the decision support system (DSS and group DSS (GDSS, emerges to assist decision maker for decision-making process. Both the DSS and GDSS should integrate with a symmetrical approach to assist decision maker to take all decision criteria into consideration simultaneously. This study proposes a GDSS architecture named hybrid decision-making support model (HDMSM and integrated four decision approaches (Delphi, DEMATEL, ANP, and MDS to help decision maker to rank and select appropriate alternatives. The HDMSM consists of five steps, namely, criteria identification, criteria correlation calculation, criteria evaluation, critical criteria selection, and alternative rank and comparison. Finally, to validate the proposed feasibility of the proposed model, this study also conducts a case study to find out the important indexes of corporate social responsibility (CSR from multiple perspectives. As the case study demonstrates the proposed HDMSM enables a group of decision makers to implement the MCDM effectively and help them to analyze the relation and degree of mutual influence among different evaluation factors.

  4. Small Berriasian, lower Valanginian and Barremian heteromorphic ammonites from the Río Argos succession (Caravaca, southeast Spain)

    NARCIS (Netherlands)

    Vasícek, V; Hoedemaeker, P.J.

    2003-01-01

    The small heteromorphic ammonites from the Berriasian, lower Valanginian and Barremian strata of the Río Argos succession (west of Caravaca, southeast Spain) are described. One new genus is introduced, Sabaudiella (type species Ancyloceras sabaudianum Pictet & de Loriol, 1858), and three new species

  5. Ammonite biostratigraphy of the uppermost Tithonian, Berriasian, and lower Valanginian along the Río Argos (Caravaca, SE Spain)

    NARCIS (Netherlands)

    Hoedemaeker, P.J.

    1982-01-01

    This paper deals with the ammonite biostratigraphy of the lower 312 m of the Miravetes Formation (sections Y and Z) exposed 500 m north and northwest of Los Miravetes along the Río Argos, 3 km west of Caravaca (SE Spain). This sequence embraces the uppermost Tithonian, Berriasian, and lower Valangin

  6. UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis.

    Science.gov (United States)

    Ranganathan, Punithavathi; Jayakumar, Calpurnia; Li, Dean Y; Ramesh, Ganesan

    2014-07-01

    The netrin-1 administration or overexpression is known to protect colon from acute colitis. However, the receptor that mediates netrin-1 protective activities in the colon during colitis remains unknown. We tested the hypothesis that UNC5B receptor is a critical mediator of protective function of netrin-1 in dextran sodium sulfate (DSS)-induced colitis using mice with partial deletion of UNC5B receptor. DSS colitis was performed in mice with partial genetic UNC5B deficiency (UNC5B(+/-) mice) or wild-type mice to examine the role of endogenous UNC5B. These studies were supported by in vitro models of DSS-induced apoptosis in human colon epithelial cells. WT mice developed colitis in response to DSS feeding as indicated by reduction in bw, reduction in colon length and increase in colon weight. These changes were exacerbated in heterozygous UNC5B knockout mice treated with DSS. Periodic Acid-Schiff stained section shows damages in colon epithelium and mononuclear cell infiltration in WT mice, which was further increased in UNC5B heterozygous knockout mice. This was associated with large increase in inflammatory mediators such as cytokine and chemokine expression and extensive apoptosis of epithelial cells in heterozygous knockout mice as compared to WT mice. Overexpression of UNC5B human colon epithelial cells suppressed DSS-induced apoptosis and caspase-3 activity. Moreover, DSS induced large amount of netrin-1 and shRNA mediated knockdown of netrin-1 induction exacerbated DSS-induced epithelial cell apoptosis. Our results suggest that UNC5B is a critical mediator of cell survival in response to stress in colon.

  7. Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.

    Science.gov (United States)

    Nighot, Prashant; Al-Sadi, Rana; Rawat, Manmeet; Guo, Shuhong; Watterson, D Martin; Ma, Thomas

    2015-12-15

    Recent studies have implicated a pathogenic role for matrix metalloproteinases 9 (MMP-9) in inflammatory bowel disease. Although loss of epithelial barrier function has been shown to be a key pathogenic factor for the development of intestinal inflammation, the role of MMP-9 in intestinal barrier function remains unclear. The aim of this study was to investigate the role of MMP-9 in intestinal barrier function and intestinal inflammation. Wild-type (WT) and MMP-9(-/-) mice were subjected to experimental dextran sodium sulfate (DSS) colitis by administration of 3% DSS in drinking water for 7 days. The mouse colonic permeability was measured in vivo by recycling perfusion of the entire colon using fluorescently labeled dextran. The DSS-induced increase in the colonic permeability was accompanied by an increase in intestinal epithelial cell MMP-9 expression in WT mice. The DSS-induced increase in intestinal permeability and the severity of DSS colitis was found to be attenuated in MMP-9(-/-) mice. The colonic protein expression of myosin light chain kinase (MLCK) and phospho-MLC was found to be significantly increased after DSS administration in WT mice but not in MMP-9(-/-) mice. The DSS-induced increase in colonic permeability and colonic inflammation was attenuated in MLCK(-/-) mice and MLCK inhibitor ML-7-treated WT mice. The DSS-induced increase in colonic surface epithelial cell MLCK mRNA was abolished in MMP-9(-/-) mice. Lastly, increased MMP-9 protein expression was detected within the colonic surface epithelial cells in ulcerative colitis cases. These data suggest a role of MMP-9 in modulation of colonic epithelial permeability and inflammation via MLCK.

  8. Pattern-recognition techniques applied to performance monitoring of the DSS 13 34-meter antenna control assembly

    Science.gov (United States)

    Mellstrom, J. A.; Smyth, P.

    1991-01-01

    The results of applying pattern recognition techniques to diagnose fault conditions in the pointing system of one of the Deep Space network's large antennas, the DSS 13 34-meter structure, are discussed. A previous article described an experiment whereby a neural network technique was used to identify fault classes by using data obtained from a simulation model of the Deep Space Network (DSN) 70-meter antenna system. Described here is the extension of these classification techniques to the analysis of real data from the field. The general architecture and philosophy of an autonomous monitoring paradigm is described and classification results are discussed and analyzed in this context. Key features of this approach include a probabilistic time-varying context model, the effective integration of signal processing and system identification techniques with pattern recognition algorithms, and the ability to calibrate the system given limited amounts of training data. Reported here are recognition accuracies in the 97 to 98 percent range for the particular fault classes included in the experiments.

  9. Influence of DSSs on urban air quality in China during 2005-2010 and analysis of a severe DSS event

    Science.gov (United States)

    Wang, Wei; Li, Liang; Pan, Benfeng; Chen, Shuang; Wang, Ruibin; Li, Jianjun; Zheng, Haohao

    2013-01-01

    In each year, Dust and Sandstorms (DSSs) triggered by cold air masses enhance particle concentration over large areas in China during spring and winter. In this paper, daily Air Pollution Index (API) of 113 major cities in China during dust events was analyzed to present the influence of DSSs on urban air quality. From 2005 to 2010, a total of 93 dust events were identified, on average there are approximately 16 dust events in a year. The number of total polluted days caused by DSSs in 113 major cities ranged from 147 to 546 each year, with maximum in 2010 and minimum in 2007. The number of total heavily polluted days caused by DSSs in major cities ranged from 14 to 78 each year, with maximum in 2010 and minimum in 2005. DSSs affected major cities most severely during March to May. Furthermore, a typical DSS observed from 26 to 31 May 2008 was described in terms of meteorological features and PM10 concentration as well as API levels of 113 major cities. This event lead to high PM10 concentration and low visibility over major cities, with maximum daily PM10 concentration of 1511 μg m-3 in Chifeng on 28 May, which was directly caused by strong wind in front of surface high pressure system passing through sand source areas in Mongolia and North China. The most severe pollution occurred on 29 May, with 38 cities polluted and 7 cities heavily polluted.

  10. IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses.

    Science.gov (United States)

    Zhu, Junfeng; Yang, Fangli; Sang, Lixuan; Zhai, Jingbo; Zhang, Xiaoqing; Yue, Dan; Li, Shengjun; Li, Yan; Lu, Changlong; Sun, Xun

    2015-01-01

    Interleukin- (IL-) 33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated diseases. IL-33 was expressed in high level on epithelial cells of intestinal tract. It suggested that IL-33 plays a potential role in inflammatory bowel diseases (IBD). We investigated the role of interleukin- (IL-) 33 in dextran sulphate sodium- (DSS-) induced acute colitis in mice using recombinant mouse IL-33 protein (rIL-33). We found that DSS-induced acute colitis was aggravated by rIL-33 treatment. rIL-33-treated DSS mice showed markedly reduced levels of interferon- (IFN-)γ and IL-17A in their colon lamina propria lymphocytes (LPL), but the levels of Th2 cytokines, such as IL-5 and IL-13, in these cells were significantly increased, compared to DSS mice treated with PBS. Our results suggested that IL-33 stimulated CD4(+)T cells and caused the cell to adopt a Th2-type response but at the same time suppressed Th17 and Th1 cell responses. Therefore, IL-33 may be involved in pathogenesis of DSS-induced acute colitis by promoting Th2 cell response in intestinal mucosa of mice. Modulation of IL-33/ST2 signaling by monoclonal antibody (mAb) could be a novel biological therapy in DSS-induced acute colitis.

  11. Present status and development trend of Argos System%Argos系统的发展现状与趋势

    Institute of Scientific and Technical Information of China (English)

    宋飞; 冯旭哲

    2012-01-01

    Argos系统作为具备单星定位能力的卫星通信系统,具有功耗低、体积小、全球覆盖以及数据实时性较好等优点,目前在对自然环境的科学观测中得到了广泛应用.从系统运行的角度,阐述了组成系统的平台部分、空间部分和地面部分;结合第二代和第三代Argos系统,分析了平台终端、空间卫星、地面系统以及主要应用四个方面的发展现状;最后对Argos系统发展趋势进行了探讨和展望.%As a satellite communication system with capability of the single-satellite positioning, Argos system has advantages of low power consumption, small size, global coverage and good real-time ability for data transmission, etc. Due to above merits, Argos system is widely applied in the scientific observation for the marine environment. The platform section, the space segment and the ground segment of which the Argos system consists, are described from the view of system operation. With a comprehensive consideration of the second and the third generation Argos system, the development status of such four aspects as the platform terminal, space satellites, the ground system and the main application field, are analyzed. Finally, an outlook for the development trend of the Argos system is given.

  12. From satellite altimetry to Argo and operational oceanography: three revolutions in oceanography

    Directory of Open Access Journals (Sweden)

    P. Y. Le Traon

    2013-10-01

    Full Text Available The launch of the French/US mission Topex/Poseidon (T/P (CNES/NASA in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large-scale sea level and ocean circulation observations was flying. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. Together with my CLS colleagues, we demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. Near-real-time high-resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 yr. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. Altimetry needs to be complemented with global in situ observations. At the end of the 90s, a major international initiative was launched to develop Argo, the global array of profiling floats. This has been an outstanding success. Argo floats now provide the most important in situ observations to monitor and understand the role of the ocean on the earth climate and for operational oceanography. This is a second revolution in oceanography. The unique capability of satellite altimetry to observe the global ocean in near-real-time at high resolution and the development of Argo were essential for the development of global operational oceanography, the third revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE was instrumental in the development of the required capabilities. This paper provides an historical perspective on the development of these three revolutions in oceanography which are very much interlinked. This is not an exhaustive review and I will mainly focus on the contributions we made together with many

  13. CRED SVP Drifting Buoy Argos_ID 24961 Data, South of Necker, in the Northwestern Hawaiian Islands, 200109-200406 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24961 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  14. CRED SVP Drifting Buoy Argos_ID 24756 Data, 10mn East of Upolu, in the American Samoa, 200307-200310 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24756 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  15. CRED SVP Drifting Buoy Argos_ID 29109 Data on the south side of Swains Island, American Samoa , 200402-200606 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29109 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  16. CRED SVP Drifting Buoy Argos_ID 24955 Data at Bank 8, in the NW Hawaiian Islands, 200110-200504 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24955 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  17. CRED SVP Drifting Buoy Argos_ID 29098 Data, Necker Island in the Northwestern Hawaiian Islands, 200307-200410 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29098 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  18. CRED SVP Drifting Buoy Argos_ID 24946 Data, north of Niihau, in the NW Hawaiian Islands, 200110-200209 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24946 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  19. CRED SVP Drifting Buoy Argos_ID 29102 Data, Lisianski Island in the Northwestern Hawaiian Islands, 200307-200310 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29102 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  20. CRED SVP Drifting Buoy Argos_ID 30288 Data near Necker in the NW Hawaiian Islands, 200209-200404 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30288 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  1. CRED SVP Drifting Buoy Argos_ID 29106 Data, Laysan Island in the Northwestern Hawaiian Islands, 200307-200411 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29106 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  2. CRED SVP Drifting Buoy Argos_ID 24754 Data, between Ofu and Tutuila, in the American Samoa, 200307-200308 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24754 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  3. CRED SVP Drifting Buoy Argos_ID 30111 Data, French Frigate Shoals in the Northwestern Hawaiian Islands, 200210-200309 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30111 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  4. CRED SVP Drifting Buoy Argos_ID 44769 Data, Enroute to Manua from Tutuila, in the American Samoa, 200402-200406 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 44769 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  5. CRED SVP Drifting Buoy Argos_ID 30311 Data between Nihoa and Niihau in the NW Hawaiian Islands, 200210-200402 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30311 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  6. CRED SVP Drifting Buoy Argos_ID 29097 Data near Nihoa Island, in the Northwestern Hawaiian Islands, 200307-200412 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29097 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  7. CRED SVP Drifting Buoy Argos_ID 29101 Data, Kure Atoll in the Northwestern Hawaiian Islands, 200308-200509 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29101 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  8. Decision Support System Research and Development Network for Agricultural and Natural Resource Management in Thailand: A TRF-DSS Experience

    Directory of Open Access Journals (Sweden)

    Thaworn Onpraphai

    2012-04-01

    Full Text Available This paper aims to introduce the Decision Support System (DSS, which is an area informatics approach to area studies, and the research network complex based on DSS’s application in Thailand. In particular, the paper presents and discusses current activities of the DSS research network at the national level in Thailand rather than being a theoretical and analytical study of the DSS mechanism or its cases. DSS has wide applications in Thailand, extending to various fields such as agricultural and natural resource management, economic and social management, historical and cultural preservation, and so on. DSS generally refers to a support system embedded into a computer system for providing intellectual resources with the appropriate numerical model necessary for decision making in production activities. Agricultural and natural resources have been the foundation of social and economic development in Thailand since the country’s first national plan in the 1960s. Decision making to maintain agricultural productivity as well as to protect natural resources requires well-integrated data sets. The Thailand Research Fund (TRF established a DSS research and development network (TRF-DSS in 2002 to help various research teams in Thailand develop DSS tools and components for addressing agricultural and natural resource management issues. Using a “systems” approach, the DSS framework allows researchers and users to identify and integrate key components as well as to define databases and model-base management systems. This paper focuses on the TRF-DSS research and development network, which consists of 12 universities, two line agencies in Thailand, and a line agency in Cambodia. During 2002–10, a total of 59 research projects were granted a budget allocation of 140.1 million baht, and a budget of 15.4 million baht was allocated to support activities of the network. In addition, 10 projects were funded to carry out postproject activities, with a

  9. A neural network-based method for merging ocean color and Argo data to extend surface bio-optical properties to depth: Retrieval of the particulate backscattering coefficient

    Science.gov (United States)

    Sauzède, R.; Claustre, H.; Uitz, J.; Jamet, C.; Dall'Olmo, G.; D'Ortenzio, F.; Gentili, B.; Poteau, A.; Schmechtig, C.

    2016-04-01

    The present study proposes a novel method that merges satellite ocean color bio-optical products with Argo temperature-salinity profiles to infer the vertical distribution of the particulate backscattering coefficient (bbp). This neural network-based method (SOCA-BBP for Satellite Ocean-Color merged with Argo data to infer the vertical distribution of the Particulate Backscattering coefficient) uses three main input components: (1) satellite-based surface estimates of bbp and chlorophyll a concentration matched up in space and time with (2) depth-resolved physical properties derived from temperature-salinity profiles measured by Argo profiling floats and (3) the day of the year of the considered satellite-Argo matchup. The neural network is trained and validated using a database including 4725 simultaneous profiles of temperature-salinity and bio-optical properties collected by Bio-Argo floats, with concomitant satellite-derived products. The Bio-Argo profiles are representative of the global open-ocean in terms of oceanographic conditions, making the proposed method applicable to most open-ocean environments. SOCA-BBP is validated using 20% of the entire database (global error of 21%). We present additional validation results based on two other independent data sets acquired (1) by four Bio-Argo floats deployed in major oceanic basins, not represented in the database used to train the method; and (2) during an AMT (Atlantic Meridional Transect) field cruise in 2009. These validation tests based on two fully independent data sets indicate the robustness of the predicted vertical distribution of bbp. To illustrate the potential of the method, we merged monthly climatological Argo profiles with ocean color products to produce a depth-resolved climatology of bbp for the global ocean.

  10. Argo floats revealing bimodality of large-scale mid-depth circulation in the North Atlantic

    Institute of Scientific and Technical Information of China (English)

    CHU Peter C; IVANOV Leonid M; MELNICHENKO Oleg V; LI Rongfeng

    2008-01-01

    Analysis of Argo float trajectories at 1000 m and temperature at 950 m in the North Atlantic between November 2003 and January 2005 demonstrates the existence of two different circulation modes with fast transition between them. Each mode has a pair of cy-clonic - anticyclonic gyres. The difference is the location of the cyclonic gyre. The cyclonic gyre stretches from southeast to north-west in the first mode and from the southwest to the northeast in the second mode. The observed modes strongly affect the heat and salt transport in the North Atlantic. In particular, the second mode slows down the westward transport of the warm and saline water from the Mediterranean Sea.

  11. La política nuclear espanyola: el caos del reactor nuclear Argos

    OpenAIRE

    Barca Salom, Francesc Xavier

    2000-01-01

    L’11 de juny de 1962 s’inaugurava a l’Escola Tècnica Superior d’Enginyeria Industrial de Barcelona un reactor nuclear experimental, que era batejat amb el nom mític d’Argos. Tota la premsa barcelonina se’n feu ressò i el presentava com el primer reactor construït íntegrament a Espanya per la Junta d’Energia Nuclear. La idea de dotar l’Escola d’un reactor nuclear havia nascut, però, set anys abans, precisament en el mateix moment de la creació de la Càtedra Ferran Tallada d’enginyeria...

  12. Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages.

    Science.gov (United States)

    Ke, Ping; Shao, Bo-Zong; Xu, Zhe-Qi; Wei, Wei; Han, Bin-Ze; Chen, Xiong-Wen; Su, Ding-Feng; Liu, Chong

    2016-01-01

    Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying mechanism remains unclear. In the present study, we examined whether activation of CB2R could suppress the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. In peritoneal macrophages isolated from C57BL/6 mice, LPS/DSS challenge for 24 h increased the expression of the components of NLRP3 inflammasome NLRP3, Casp-1 p20/Casp-1 p45 ratio, proIL-1β and IL-1β and also enhanced autophagy (LC3-II/LC3-I ratio, Beclin-1 and SQSTM1). Pretreatment of peritoneal macrophages with HU 308, a selective CB2R agonist, attenuated LPS/DSS-induced NLRP3 inflammasome activation, but further enhanced autophagy. In comparison with wild-type (WT) control, peritoneal macrophages from CB2R knockout (KO) mice had more robust NLRP3 inflammasome activation and attenuated autophagy upon LPS/DSS challenge. Knockdown autophagy-related gene 5 (Atg5) with a siRNA in peritoneal macrophages attenuated the inhibitory effects of HU 308 on LPS/DSS-induced NLRP3 inflammasome activation in vitro. In vivo, HU308 treatment attenuated DSS-induced colitis mice associated with reduced colon inflammation and inhibited NLRP3 inflammasome activation in wild-type mice. In CB2R KO mice, DSS-induced inflammation and NLRP3 inflammasome activation were more pronounced than those in WT control. Finally, we demonstrated that AMPK-mTOR-P70S6K signaling pathway was involved in this CB2R-mediated process. We conclude that activation of CB2R ameliorates DSS-induced colitis through enhancing autophagy that may inhibit NLRP3 inflammasome activation in macrophages.

  13. 远洋不定期船经营DSS系统的分析与设计%The DSS analysis and design on ocean tramp operation

    Institute of Scientific and Technical Information of China (English)

    吕靖; 王蓬; 王腾飞

    2000-01-01

    针对远洋不定期船经营决策中的实际问题,结合我国航运企业特点,通过对船舶不定期船生产经营活动决策过程中所存在的实际问题的系统分析,实现了远洋不定期船经营决策的DSS辅助决策支持.%According to the existing problem lying in the shipping company's tramp operation decision and to the general features of China's shipping company management, this paper analyses systematically the practical problems lying in the process of tramp operation decision. The DSS assistant-decision support in the shipping company's strategy of operation and development is realized.

  14. Impacts of XBT, TAO, Altimetry and ARGO Observations on the Tropical Pacific Ocean Data Assimilation

    Institute of Scientific and Technical Information of China (English)

    YAN Changxiang; ZHU Jiang; ZHOU Guangqing

    2007-01-01

    This study aims at assessing the relative impacts of four major components of the tropical Pacific Ocean observing system on assimilation of temperature and salinity fields. Observations were collected over a period between January 2001 through June 2003 including temperature data from the expendable bathythermographs (XBT), thermistor data from the Tropical Ocean Global Atmosphere Tropical Atmosphere-Ocean (TOGA-TAO) mooring array, sea level anomalies from the Topex/Poseidon and Jason-1 altimetry (T/P-J),and temperature and salinity profiles from the Array for Real-time Geostrophic Oceanography (ARGO) floats.An efficient three-dimensional variational analysis-based method was introduced to assimilate the above data into the tropical-Pacific circulation model. To evaluate the impact of the individual component of the observing system, four observation system experiments were carried out. The experiment that assimilated all four components of the observing system was taken as the reference. The other three experiments were implemented by withholding one of the four components. Results show that the spatial distribution of the data influences its relative contribution. XBT observations produce the most distinguished effects on temperature analyses in the off-equatorial region due to the large amount of measurements and high quality.Similarly, the impact of TAO is dominant in the equatorial region due to the focus of the spatial distribution.The Topex/Poseidon-Jason-1 can be highly complementary where the XBT and TAO observations are sparse.The contribution of XBT or TAO on the assimilated salinity is made by the model dynamics because no salinity observations from them are assimilated. Therefore, T/P-J, as a main source for providing salinity data, has been shown to have greater impacts than either XBT or TAO on the salinity analysis. Although ARGO includes the subsurface observations, the relatively smaller number of observation makes it have the smallest

  15. Error properties of Argos satellite telemetry locations using least squares and Kalman filtering.

    Directory of Open Access Journals (Sweden)

    Janice D Boyd

    Full Text Available Study of animal movements is key for understanding their ecology and facilitating their conservation. The Argos satellite system is a valuable tool for tracking species which move long distances, inhabit remote areas, and are otherwise difficult to track with traditional VHF telemetry and are not suitable for GPS systems. Previous research has raised doubts about the magnitude of position errors quoted by the satellite service provider CLS. In addition, no peer-reviewed publications have evaluated the usefulness of the CLS supplied error ellipses nor the accuracy of the new Kalman filtering (KF processing method. Using transmitters hung from towers and trees in southeastern Peru, we show the Argos error ellipses generally contain <25% of the true locations and therefore do not adequately describe the true location errors. We also find that KF processing does not significantly increase location accuracy. The errors for both LS and KF processing methods were found to be lognormally distributed, which has important repercussions for error calculation, statistical analysis, and data interpretation. In brief, "good" positions (location codes 3, 2, 1, A are accurate to about 2 km, while 0 and B locations are accurate to about 5-10 km. However, due to the lognormal distribution of the errors, larger outliers are to be expected in all location codes and need to be accounted for in the user's data processing. We evaluate five different empirical error estimates and find that 68% lognormal error ellipses provided the most useful error estimates. Longitude errors are larger than latitude errors by a factor of 2 to 3, supporting the use of elliptical error ellipses. Numerous studies over the past 15 years have also found fault with the CLS-claimed error estimates yet CLS has failed to correct their misleading information. We hope this will be reversed in the near future.

  16. Error properties of Argos satellite telemetry locations using least squares and Kalman filtering.

    Science.gov (United States)

    Boyd, Janice D; Brightsmith, Donald J

    2013-01-01

    Study of animal movements is key for understanding their ecology and facilitating their conservation. The Argos satellite system is a valuable tool for tracking species which move long distances, inhabit remote areas, and are otherwise difficult to track with traditional VHF telemetry and are not suitable for GPS systems. Previous research has raised doubts about the magnitude of position errors quoted by the satellite service provider CLS. In addition, no peer-reviewed publications have evaluated the usefulness of the CLS supplied error ellipses nor the accuracy of the new Kalman filtering (KF) processing method. Using transmitters hung from towers and trees in southeastern Peru, we show the Argos error ellipses generally contain <25% of the true locations and therefore do not adequately describe the true location errors. We also find that KF processing does not significantly increase location accuracy. The errors for both LS and KF processing methods were found to be lognormally distributed, which has important repercussions for error calculation, statistical analysis, and data interpretation. In brief, "good" positions (location codes 3, 2, 1, A) are accurate to about 2 km, while 0 and B locations are accurate to about 5-10 km. However, due to the lognormal distribution of the errors, larger outliers are to be expected in all location codes and need to be accounted for in the user's data processing. We evaluate five different empirical error estimates and find that 68% lognormal error ellipses provided the most useful error estimates. Longitude errors are larger than latitude errors by a factor of 2 to 3, supporting the use of elliptical error ellipses. Numerous studies over the past 15 years have also found fault with the CLS-claimed error estimates yet CLS has failed to correct their misleading information. We hope this will be reversed in the near future. PMID:23690980

  17. Salinity variability in the North Atlantic through synergetic analysis of Argo floats and satellite altimetry data

    Science.gov (United States)

    Stendardo, Ilaria; Rhein, Monika; Klein, Birgit; Roessler, Achim

    2015-04-01

    Salinity distribution in the North Atlantic is affected by changes in the circulation and freshwater fluxes. Changes in salinity are introduced into the ocean's interior by vertical processes like subduction or convection, and transported along circulation pathways. At a given location and depth, salinity could vary by water mass changes due to changes in the freshwater flux, or by vertical migration of density surfaces caused either by wind-driven changes of ocean ventilation or by thermodynamic processes, like poleward migration of isopycnals as a result of surface warming. Changes in the wind driven circulation with a consequence shift of the subpolar front, that separates the fresher subpolar from the saline subtropical gyre, also have a marked influence on upper ocean salinity in the subpolar North Atlantic. Due to the lack of temporal and spatial resolution of salinity observations, salinity anomalies in the last century could only be studied by 5-year means. Thanks to the Argo program, the temporal and spatial resolution of salinity and temperature profiles since early 2000 have significantly improved, allowing to calculate even monthly means. To further improve temporal and spatial resolution of salinity, Argo profiles are combined with altimetry data and a "Transfer function", the Gravest Empirical Mode (GEM), is calculated. The GEM technique exploits the relationship between T/S profiles and dynamic height in order to parameterize salinity data as a function of dynamic height from the satellite altimetry. This technique gives the opportunity to extend the investigation of the salinity variability, with extremely high temporal (daily) and spatial (1/4°) resolution, back to 1993, the beginning of the altimetry data. This method was tested on several regions of the North Atlantic and it works particularly well for some of them, for example in the regions where the North Atlantic Current plays an important role. Within these regions salinity variability in

  18. Estimation of eddy heat transport in the global ocean from Argo data

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhiwei; ZHONG Yisen; TIAN Jiwei; YANG Qingxuan; ZHAO Wei

    2014-01-01

    The Argo data are used to calculate eddy (turbulence) heat transport (EHT) in the global ocean and analyze its horizontal distribution and vertical structure. We calculate the EHT by averaging all the v′, T′ profiles within each 2◦× 2◦ bin. The velocity and temperature anomalies are obtained by removing their clima-tological values from the Argo“instantaneous”values respectively. Through the Student’s t-test and an error evaluation, we obtained a total of 87% Argo bins with significant depth-integrated EHTs (D-EHTs). The results reveal a positive-and-negative alternating D-EHT pattern along the western boundary currents (WBC) and Antarctic Circumpolar Current (ACC). The zonally-integrated D-EHT (ZI-EHT) of the global o-cean reaches 0.12 PW in the northern WBC band and-0.38 PW in the ACC band respectively. The strong ZI-EHT across the ACC in the global ocean is mainly caused by the southern Indian Ocean. The ZI-EHT in the above two bands accounts for a large portion of the total oceanic heat transport, which may play an important role in regulating the climate. The analysis of vertical structures of the EHT along the 35◦N and 45◦S section reveals that the oscillating EHT pattern can reach deep in the northern WBC regions and the Agulhas Return Current (ARC) region. It also shows that the strong EHT could reach 600 m in the WBC re-gions and 1 000 m in the ARC region, with the maximum mainly located between 100 and 400 m depth. The results would provide useful information for improving the parameterization scheme in models.

  19. Implementation of GIS-DSS PRANA within sustainable rehabilitation of radioactive contaminated territories

    International Nuclear Information System (INIS)

    Full text: Analysis of the current situation in contaminated farms and settlements of Bryansk region is based on the monitoring data and model estimates. Model assessments of agricultural produce contamination, doses to the local population, radiological risk and results of countermeasure (CM) implementation have been carried out with the use of PRANA GIS-DSS. Applied Geographic Information System (GIS) PRANA is a Decision Support System (DSS) for implementation within the rehabilitation of radioactive contaminated territories. PRANA has been introduced for practical use in Bryansk as a GIS-DSS system for monitoring networking support and countermeasure analysis. The main blocks of the PRANA DSS are: libraries of electronic maps, including different layers of vector maps of landuse for all contaminated districts of Bryansk region: Novozybkov, Klintsy, Gordeevsky, Krasnogorsky, Zlynkovsky and Klimovsky (more than 30000 polygons of vector electronic maps); databases (radioecological, ecological, economic, demographic and other monitoring data and model parameters, including attributive information of vector electronic maps); model blocks for assessing: contamination of agricultural production, external and internal doses to the local population, radiological risks and corresponding results of CMs implementation; evaluation of CMs effectiveness and decision-making support an protection of the population and rehabilitation of radioactive contaminated territories both on local and regional/district levels (from separate settlement/field up to group of settlements/farms and region as a whole). The following 'risk indices' are considered within decision-making an Risk Based Land Management (RBLM) with the use of PRANA DSS: surface density contamination of territory with radionuclides (137Cs, 90Sr); contamination of agricultural production (plant growing and animal husbandry, including farm and private production); external and internal doses to the local population (for

  20. Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming.

    Science.gov (United States)

    Liu, Jing; Xiao, Hai-Tao; Wang, Hong-Sheng; Mu, Huai-Xue; Zhao, Ling; Du, Jun; Yang, Depo; Wang, Dongmei; Bian, Zhao-Xiang; Lin, Shu-Hai

    2016-06-21

    Hypoxia and inflammation have been identified as the hallmarks of colitis, intertwined with metabolism. Here, we report that halofuginone (HF), an antiparasitic drug, attenuates dextran sulfate sodium (DSS)-induced colitis in mice, as represented by attenuating the disease activity index, inhibiting colonic shortening, ameliorating colonic lesions and histological signs of damage, reducing colonic myeloperoxidase activity, and suppressing the production of pro-inflammatory cytokines in colon tissue. Intriguingly, the hypoxia-inducible factor 1alpha (HIF-1α) and tumor necrosis factor alpha were also suppressed by HF treatment in colon tissues, exhibiting a tissue-specific effect. To further reveal the metabolic signatures upon HF treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in liver, spleen and colon tissues was performed. As a result, we found that HF treatment counteracted the levels of acylcarnitines, including palmitoyl-l-carnitine, isobutyrylcarnitine, vaccenylcarnitine, and myristoylcarnitine, in colon tissues with DSS induction, but no significant change in the levels of acylcarnitines was observed in liver or spleen tissues. The metabolic signatures may indicate that incomplete fatty acid oxidation (FAO) in the colon could be restored upon HF treatment as the tissue-specific metabolic characterization. Taken together, our findings uncovered that the HF potentiated anti-inflammatory effect in DSS-induced colitis in mice and its underlying mechanisms could be associated with the inhibition of HIF-1α and reduced levels of acylcarnitines, suggesting that both the inhibition of HIF-1α and the counteraction of incomplete FAO might be useful in the prevention and treatment of inflammatory bowel disease.

  1. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats.

    Directory of Open Access Journals (Sweden)

    Olof Schreiber

    Full Text Available AIM: To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. METHODS: Colitis was induced with 5% DSS in drinking water for 8 days prior to experiment, when the descending colonic mucosa of anesthetized rats was studied using intravital microscopy. Mucus thickness was measured with micropipettes attached to a micromanipulator. To assess the contributions of NOS and prostaglandins in the regulation of colonic mucus thickness, the non-selective NOS-inhibitor L-NNA (10 mg/kg bolus followed by 3 mg/kg/h, the selective iNOS-inhibitor L-NIL (10 mg/kg bolus followed by 3 mg/kg/h and the non-selective COX-inhibitor diclofenac (5 mg/kg were administered intravenously prior to experiment. To further investigate the role of iNOS in the regulation of colonic mucus thickness, iNOS -/- mice were used. RESULTS: Colitic rats had a thicker firmly adherent mucus layer following 8 days of DSS treatment than untreated rats (88±2 µm vs 76±1 µm. During induction of colitis, the thickness of the colonic mucus layer initially decreased but was from day 3 significantly thicker than in untreated rats. Diclofenac reduced the mucus thickness similarly in colitic and untreated rats (-16±5 µm vs -14±2 µm. While L-NNA had no effect on colonic mucus thickness in DSS or untreated controls (+3±2 µm vs +3±1 µm, L-NIL reduced the mucus thickness significantly more in colitic rats than in controls (-33±4 µm vs -10±3 µm. The importance of iNOS in regulating the colonic mucus thickness was confirmed in iNOS-/- mice, which had thinner colonic mucus than wild-type mice (35±3 µm vs 50±2 µm, respectively. Furthermore, immunohistochemistry revealed increased levels of iNOS in the colonic surface epithelium following DSS treatment. CONCLUSION: Both prostaglandins and nitric oxide regulate basal colonic mucus thickness. During onset of colitis, the thickness of the mucus layer is initially reduced followed by an i

  2. The impact of Ag nanoparticles on the parameters of DSS- cells sensitized by Z907

    Science.gov (United States)

    Ibrayev, N. Kh; Aimukhanov, A. K.; Zeinidenov, A. K.

    2016-02-01

    Research of influence of Ag nanoparticles are in-process undertaken on absorption and on parameters CVC DSS-cells sensitized Z907. It is set that with the height of concentration Ag nanoparticles in tape to the concentration of 0.3% wt%. the absorbance of Z907 in a short-wave stripe grew to the value 1,6. It is set that under reaching the concentration of Ag nanoparticles in the cell of value the 0.3% wt%. efficiency of cell increased to 2.2%.

  3. LandCaRe-DSS - model based tools for irrigation management under climate change

    Science.gov (United States)

    Dotterweich, Markus; Wilkinson, Kristina; Cassel, Martin; Scherzer, Jörg; Köstner, Barbara; Berg, Michael; Grocholl, Jürgen

    2015-04-01

    Climate change is expected to have a strong influence on agricultural systems in the future. It will be important for decision makers and stakeholders to assess the impact of climate change at the farm and regional level in order to facilitate and maintain a sustainable and profitable farming infrastructure. Climate change impact studies have to incorporate aspects of uncertainty and the underlying knowledge is constantly expanding and improving. Decision support systems (DSS) with flexible data bases are therefore a useful tool for management and planning: different models can be applied under varying boundary conditions within a conceptual framework and the results can be used e.g. to show the effects of climate change scenarios and different land management options. Within this project, the already existing LandCaRe DSS will be further enhanced and improved. A first prototype had been developed for two regions in eastern Germany, mainly to show the effects of climate change on yields, nutrient balances and farm economy. The new model version will be tested and applied for a region in north-western Germany (Landkreis Uelzen) where arable land makes up about 50% of overall land-use and where 80 % of the arable land is already irrigated. For local decision makers, it will be important to know how water demand and water availability are likely to change in the future: Is more water needed for irrigation? Is more water actually available for irrigation? Will the existing limits for ground water withdrawal be sufficient for farmers to irrigate their crops? How can the irrigation water demand be influenced by land management options like the use of different crops and varieties or different farming and irrigation techniques? The main tasks of the project are (I) the integration of an improved irrigation model, (II) the development of a standardized interface to apply the DSS in different regions, (III) to optimize the graphical user interface, (IV) to transfer and

  4. Microhardness changes gradient of the duplex stainless steel (DSS surface layer after dry turning

    Directory of Open Access Journals (Sweden)

    G. Krolczyk

    2014-10-01

    Full Text Available The article presents the gradient of microhardness changes as a function of the distance from the material surface after turning with a wedge provided with a coating with a ceramic intermediate layer. The investigation comprised the influence of cutting speed on surface integrity microhardness in dry machining. The tested material was duplex stainless steel (DSS with two-phase, ferritic-austenitic structure. The tests have been performed under production conditions during machining of parts for electric motors and deep-well pumps.

  5. Energy consumption analysis of the Venus Deep Space Station (DSS-13)

    Science.gov (United States)

    Hayes, N. V.

    1983-01-01

    This report continues the energy consumption analysis and verification study of the tracking stations of the Goldstone Deep Space Communications Complex, and presents an audit of the Venus Deep Space Station (DSS 13). Due to the non-continuous radioastronomy research and development operations at the station, estimations of energy usage were employed in the energy consumption simulation of both the 9-meter and 26-meter antenna buildings. A 17.9% decrease in station energy consumption was experienced over the 1979-1981 years under study. A comparison of the ECP computer simulations and the station's main watt-hour meter readings showed good agreement.

  6. Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice.

    Science.gov (United States)

    Zhao, Hongyu; Yan, Rui; Zhou, Xiaogang; Ji, Fang; Zhang, Bing

    2016-10-01

    Intestinal barrier involves in the pathogeny of inflammatory bowel disease (IBD) and hydrogen sulfide (H2S) has been reported to improve intestinal barrier integrity. Thus, this study investigated the effects of GYY4137, a slow-release H2S donor, on DSS-induced inflammation and intestinal dysfunction. In vitro model, cellular permeability was significantly increased and expression of tight junctions (ZO-1, Cauldin4, and Occludin) was downregulated in Caco-2 cells. GYY4137 treatment markedly attenuated DSS-induced inflammation and barrier dysfunction. Cystathionine β-synthase (CBS)-siRNA transfection further demonstrated that endogenous H2S system involves in DSS-induced inflammation and mediates barrier function. In vivo model, DSS exposure caused colonic inflammation and injury in mice and GYY4137 injection alleviated inflammatory response and improved intestinal barrier via reducing intestinal permeability and upregulating of tight junctions. In conclusion, endogenous H2S system involves in DSS-induced inflammation and H2S addition alleviated inflammation and intestinal dysfunction in vitro and in vivo.

  7. Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis.

    Science.gov (United States)

    He, Xuexiu; Wei, Zhengkai; Wang, Jingjing; Kou, Jinhua; Liu, Weijian; Fu, Yunhe; Yang, Zhengtao

    2016-06-20

    Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. However, the effect of alpinetin on inflammatory bowel disease (IBD) has not yet been reported. The purpose of this study was to investigate the anti-inflammatory effect and mechanism of alpinetin on dextran sulfate sodium (DSS)-induced colitis in mice. In vivo, DSS-induced mice colitis model was established by giving mice drinking water containing 5% (w/v) DSS for 7 days. Alpinetin (25, 50 and 100 mg/kg) were administered once a day by intraperitoneal injection 3 days before DSS treatment. In vitro, phorbol myristate acetate (PMA)-differentiated monocytic THP-1 macrophages were treated with alpinetin and stimulated by lipopolysaccharide (LPS). The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-α) and interleukin (IL-1β) production in mice. In vitro, alpinetin markedly inhibited LPS-induced TNF-α and IL-1β production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-κB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation. In conclusion, this study demonstrated that alpinetin had protective effects on DSS-induced colitis and may be a promising therapeutic reagent for colitis treatment.

  8. Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium.

    Science.gov (United States)

    Zhang, Qianpeng; Wu, Yanqiu; Wang, Jing; Wu, Guojun; Long, Wenmin; Xue, Zhengsheng; Wang, Linghua; Zhang, Xiaojun; Pang, Xiaoyan; Zhao, Yufeng; Zhao, Liping; Zhang, Chenhong

    2016-06-06

    Butyrate-producing bacteria (BPB) are potential probiotic candidates for inflammatory bowel diseases as they are often depleted in the diseased gut microbiota. However, here we found that augmentation of a human-derived butyrate-producing strain, Anaerostipes hadrus BPB5, significantly aggravated colitis in dextran sulphate sodium (DSS)-treated mice while exerted no detrimental effect in healthy mice. We explored how the interaction between BPB5 and gut microbiota may contribute to this differential impact on the hosts. Butyrate production and severity of colitis were assessed in both healthy and DSS-treated mice, and gut microbiota structural changes were analysed using high-throughput sequencing. BPB5-inoculated healthy mice showed no signs of colitis, but increased butyrate content in the gut. In DSS-treated mice, BPB5 augmentation did not increase butyrate content, but induced significantly more severe disease activity index and much higher mortality. BPB5 didn't induce significant changes of gut microbiota in healthy hosts, but expedited the structural shifts 3 days earlier toward the disease phase in BPB5-augmented than DSS-treated animals. The differential response of gut microbiota in healthy and DSS-treated mice to the same potentially beneficial bacterium with drastically different health consequences suggest that animals with dysbiotic gut microbiota should also be employed for the safety assessment of probiotic candidates.

  9. Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium.

    Science.gov (United States)

    Zhang, Qianpeng; Wu, Yanqiu; Wang, Jing; Wu, Guojun; Long, Wenmin; Xue, Zhengsheng; Wang, Linghua; Zhang, Xiaojun; Pang, Xiaoyan; Zhao, Yufeng; Zhao, Liping; Zhang, Chenhong

    2016-01-01

    Butyrate-producing bacteria (BPB) are potential probiotic candidates for inflammatory bowel diseases as they are often depleted in the diseased gut microbiota. However, here we found that augmentation of a human-derived butyrate-producing strain, Anaerostipes hadrus BPB5, significantly aggravated colitis in dextran sulphate sodium (DSS)-treated mice while exerted no detrimental effect in healthy mice. We explored how the interaction between BPB5 and gut microbiota may contribute to this differential impact on the hosts. Butyrate production and severity of colitis were assessed in both healthy and DSS-treated mice, and gut microbiota structural changes were analysed using high-throughput sequencing. BPB5-inoculated healthy mice showed no signs of colitis, but increased butyrate content in the gut. In DSS-treated mice, BPB5 augmentation did not increase butyrate content, but induced significantly more severe disease activity index and much higher mortality. BPB5 didn't induce significant changes of gut microbiota in healthy hosts, but expedited the structural shifts 3 days earlier toward the disease phase in BPB5-augmented than DSS-treated animals. The differential response of gut microbiota in healthy and DSS-treated mice to the same potentially beneficial bacterium with drastically different health consequences suggest that animals with dysbiotic gut microbiota should also be employed for the safety assessment of probiotic candidates. PMID:27264309

  10. LIDERAZGO, LA COMPETENCIA ESENCIAL QUE TRANSFORMÓ UNA EMPRESA COLOMBIANA EN UN GIGANTE INTERNACIONAL: EL CASO DE CEMENTOS ARGOS

    Directory of Open Access Journals (Sweden)

    HÉCTOR OCHOA DÍAZ

    2011-01-01

    Full Text Available Cementos Argos ha sido catalogado como uno de los gigantes de la industria cementera colombiana por su gran capacidad de consolidación en el mercado nacional y sus estrategias de internacionalización poco convencionales. Esta investigación documenta la experiencia internacional de Argos bajo la perspectiva de las teorías de internacionalización de mayor aceptación en laliteratura internacional, haciendo uso del enfoque metodológico de los estudios de caso. Como resultado se encontró que las estrategias de fidelización,aunadas al rediseño organizacional resultado del liderazgo de la alta gerencia, han sido herramientas vitales para asegurar el crecimiento de la compañía en los mercados local y externo.

  11. Evaluation of Mid-Depth Currents of NCEP Reanalysis Data in the Tropical Pacific Using ARGO Float Position Information

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The global project of the Array for Real-time Geostrophic Oceanography (ARGO) provides a unique opportunity to observe the absolute velocity in mid-depths of the world oceans. A total of 1597 velocity vectors at 1000 (2000) db in the tropical Pacific derived from the ARGO float position information during the period November 2001 to October 2004 are used to evaluate the intermediate currents of the National Centers for Environmental Prediction reanalysis. To derive reliable velocity information from ARGO float trajectory points, a rigorous quality control scheme is applied, and by virtue of a correction method for reducing the drift error on the surface in obtaining the velocity vectors, their relative errors are less than 25%. Based on the comparisons from the quantitative velocity vectors and from the space-time average currents, some substantial discrepancies are revealed. The first is that the velocities of the reanalysis at mid-depths except near the equator are underestimated relative to the observed velocities by the floats.The average speed difference between NCEP and ARGO values ranges from about -2.3 cms-1 to -1.8cms-1. The second is that the velocity difference between the ocean model and the observations at 2000dB seems smaller than that at 1000 dB. The third is that the zonal flow in the reanalysis is too dominant so that some eddies could not be simulated, such as the cyclonic eddy to the east of 160°E between 20°N and 30°N at 2000 dB. In addition, it is noticeable that many floats parking at 1000 dB cannot acquire credible mid-depth velocities due to the time information of their end of ascent (start of descent) on the surface in the trajectory files. Thus, relying on default times of parking, descent and ascent in the metadata files gravely confines their application to measuring mid-depth currents.

  12. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data.

    Directory of Open Access Journals (Sweden)

    Andrew D Lowther

    Full Text Available Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE for each optimal SSM were less than 4.25 km with some producing RMSE of less than 2.50 km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution.

  13. Uppermost Jurassic to Lower Cretaceous benthic foraminiferal biostratigraphy at ODP Site 765 on the Argo Abyssal Plain.

    OpenAIRE

    Kaminski, M.A.; Gradstein, F.M.; Geroch, S.

    1992-01-01

    Benthic foraminifers were studied in 99 samples collected from the lower 200 m of Hole 765C. The studied section ranges from the Tithonian to Aptian, and benthic foraminifers can be subdivided into five assemblages on the basis of faunal diversity and stratigraphic ranges of distinctive species. Compared with deep-water assemblages from Atlantic DSDP sites and Poland, assemblages from the Argo Abyssal Plain display a higher diversity of agglutinated forms, which comprise the autochthonous ...

  14. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data.

    Science.gov (United States)

    Lowther, Andrew D; Lydersen, Christian; Fedak, Mike A; Lovell, Phil; Kovacs, Kit M

    2015-01-01

    Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs) to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE) for each optimal SSM were less than 4.25 km with some producing RMSE of less than 2.50 km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution.

  15. Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice.

    Science.gov (United States)

    Wang, Yungang; Tian, Jie; Tang, Xinyi; Rui, Ke; Tian, Xinyu; Ma, Jie; Ma, Bin; Xu, Huaxi; Lu, Liwei; Wang, Shengjun

    2016-03-29

    Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel disease (IBD), but their role in the disease remains controversial. We sought to define the effect of granulocytic MDSC-derived exosomes (G-MDSC exo) in dextran sulphate sodium (DSS)-induced murine colitis. G-MDSC exo-treated mice showed greater resistance to colitis, as reflected by lower disease activity index, decreased inflammatory cell infiltration damage. There was a decrease in the proportion of Th1 cells and an increase in the proportion of regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) from G-MDSC exo-treated colitis mice. Moreover, lower serum levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α were detected in G-MDSC exo-treated colitis mice. Interestingly, inhibition of arginase (Arg)-1 activity in G-MDSC exo partially abrogated the spontaneous improvement of colitis. In addition, G-MDSC exo could suppress CD4+ T cell proliferation and IFN-γ secretion in vitro and inhibit the delayed-type hypersensitivity (DTH) response, and these abilities were associated with Arg-1 activity. Moreover, G-MDSC exo promoted the expansion of Tregs in vitro. Taken together, these results suggest that G-MDSC exo attenuate DSS-induced colitis through inhibiting Th1 cells proliferation and promoting Tregs expansion.

  16. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation.

    Science.gov (United States)

    Heinsbroek, Sigrid E M; Williams, David L; Welting, Olaf; Meijer, Sybren L; Gordon, Siamon; de Jonge, Wouter J

    2015-12-01

    β-Glucans have beneficial health effects due to their immune modulatory properties. Oral administration of β-glucans affects tumour growth, microbial infection, sepsis, and wound healing. We hypothesized that pre-treatment with orally delivered soluble and particulate β-glucans could ameliorate the development of aggravate dextran sulfate sodium (DSS) induced intestinal inflammation. To study this, mice were orally pre-treated with β-glucans for 14 days. We tested curdlan (a particulate β-(1,3)-glucan), glucan phosphate (a soluble β-(1,3)-glucan), and zymosan (a particle made from Saccharomyces cerevisiae, which contains around 55% β-glucans). Weight loss, colon weight, and feces score did not differ between β-glucan and vehicle treated groups. However, histology scores indicated that β-glucan-treated mice had increased inflammation at a microscopic level suggesting that β-glucan treatment worsened intestinal inflammation. Furthermore, curdlan and zymosan treatment led to increased colonic levels of inflammatory cytokines and chemokines, compared to vehicle. Glucan phosphate treatment did not significantly affect cytokine and chemokine levels. These data suggest that particulate and soluble β-glucans differentially affect the intestinal immune responses. However, no significant differences in other clinical colitis scores between soluble and particulate β-glucans were found in this study. In summary, β-glucans aggravate the course of dextran sulfate sodium (DSS)-induced intestinal inflammation at the level of the mucosa.

  17. Determinants of fertility in rural Ethiopia: the case of Butajira Demographic Surveillance System (DSS

    Directory of Open Access Journals (Sweden)

    Worku Alemayehu

    2011-10-01

    Full Text Available Abstract Background Fertility is high in rural Ethiopia. Women in the reproductive age group differed in various characteristics including access to food and encounter to drought which requisite the assessment of determinants of fertility. Methods Reproductive age women were recruited from a DSS, the Butajira DSS database. A DHS maternity history questionnaire was administered on 9996 participants. Data quality was assured besides ethical clearance. Poisson regression crude and adjusted Incidence Rate Ratio with 95 Confidence Interval were used to identify determinants of fertility. Results Delayed marriage, higher education, smaller family, absence of child death experience and living in food-secured households were associated with small number of children. Fertility was significantly higher among women with no child sex preference. However, migration status of women was not statistically significant. Conclusions Policy makers should focus on hoisting women secondary school enrollment and age at first marriage. The community should also be made aware on the negative impact of fertility on household economy, environmental degradation and the country's socio-economic development at large.

  18. Bacterial β-(1,3)-glucan prevents DSS-induced IBD by restoring the reduced population of regulatory T cells.

    Science.gov (United States)

    Lee, Kwang-Ho; Park, Min; Ji, Kon-Young; Lee, Hwa-Youn; Jang, Ji-Hun; Yoon, Il-Joo; Oh, Seung-Su; Kim, Su-Man; Jeong, Yun-Hwa; Yun, Chul-Ho; Kim, Mi-Kyoung; Lee, In-Young; Choi, Ha-Rim; Ko, Ki-sung; Kang, Hyung-Sik

    2014-10-01

    Bacterial β-(1,3)-glucan has more advantages in terms of cost, yield and efficiency than that derived from mushrooms, plants, yeasts and fungi. We have previously developed a novel and high-yield β-(1,3)-glucan produced by Agrobacterium sp. R259. This study aimed to elucidate the functional mechanism and therapeutic efficacy of bacterial β-(1,3)-glucan in dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).Mice were orally pretreated with bacterial β-(1,3)-glucan at daily doses of 2.5 or 5mg/kg for 2 weeks. After 6 days of DSS treatment, clinical assessment of IBD severity and expression of pro-inflammatory cytokines were evaluated. In vivo cell proliferation was examined by immunohistochemistry using Ki-67 and ER-TR7 antibodies. The frequency of regulatory T cells (Tregs) was analyzed by flow cytometry. Natural killer (NK) activity and IgA level were evaluated using NK cytotoxicity assay and ELISA.The deterioration of body weight gain, colonic architecture, disease score and histological score was recovered in DSS-induced IBD mice when pretreated with bacterial β-(1,3)-glucan. The recruitment of macrophages and the gene expression of proinflammatory cytokines, such as IL-1β, IL-6 and IL-17A/F, were markedly decreased in the colon of β-(1,3)-glucan-pretreated mice. β-(1,3)-Glucan induced the recovery of Tregs in terms of their frequency in DSS-induced IBD mice. Intriguingly, β-(1,3)-glucan reversed the functional defects of NK cells and excessive IgA production in DSS-induced IBD mice.We conclude that bacterial β-(1,3)-glucan prevented the progression of DSS-induced IBD by recovering the reduction of Tregs, functional defect of NK cells and excessive IgA production.

  19. Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.

    Science.gov (United States)

    Zheng, Naiyu; Zeng, Jianing; Ji, Qin C; Angeles, Aida; Aubry, Anne-Francoise; Basdeo, Shenita; Buzescu, Adela; Landry, Ishani Savant; Jariwala, Navin; Turley, Wesley; Burrell, Richard; Arnold, Mark E

    2016-08-31

    Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home. A UHPLC-MS/MS assay was developed using detergent-assisted sample extraction to quantify BMS-927711, a drug candidate in development for the treatment of migraines, in human DSS. By implementing DSS sampling at the patients' home, the bioanalytical sample collection for pharmacokinetic evaluation can be done at the time of the acute migraine attack without the need for clinical visits. DSS samples were prepared by spotting 15 μL of liquid saliva onto regular Whatman FTA™ DMPK-C cards and verified with a UV lamp (at λ 254 nm or 365 nm) during DSS punching. The 4-mm DSS punches in a 96-well plate were sonicated with 200 μL of [(13)C2, D4]-BMS-927711 internal standard (IS) solution in 20/80 MeOH/water for 10 min, followed by sonication with 50 μL of 100 mM NH4OAc with 1.0% Triton-X-100 (as detergent) prior to liquid-liquid extraction with 600 μL EtOAc/Hexane (90:10). UHPLC-MS/MS was performed with an Aquity(®) UPLC BEH C18 Column (2.1 × 50 mm, 1.7 μm) on a Triple Quad™ 5500 mass spectrometer. The assay was linear with a concentration range from 2.00 to 1000 ng mL(-1) for BMS-927711 in human saliva. The intra- and inter-assay precision was within 8.8% CV, and the accuracy was within ±6.7% Dev of the nominal concentration values. This UHPLC-MS/MS assay has been successfully applied to determine the drug's pharmacokinetics within a clinical study. For the first time, we observed BMS-927711 exposure in human DSS, confirming the suitability of this sampling technique for migraine patients to use at home. Detergent-assisted extraction with Triton-X-100 could be very useful in DSS or other dried matrix spot (DMS) assays to overcome low or inconsistent analyte recovery issues.

  20. Augmented activity of the pelvic nerve afferent mediated by TRP channels in dextran sulfate sodium (DSS)-induced colitis of rats.

    Science.gov (United States)

    Makimura, Yukitoshi; Ito, Koichi; Kuwahara, Masayoshi; Tsubone, Hirokazu

    2012-08-01

    Enteritis has been recognized as a major symptom in domestic animals and human patients suffering from feed and food poisonings. The aim of the present study was to clarify the excitatory mechanism of the pelvic nerve afferent which may influence the occurrence of enteritis in response to nociceptive chemical stimuli of the colon in normal and abnormal rats with colitis induced by dextran sulfate sodium (DSS). The pelvic nerve afferent activity was markedly increased by colonic instillation of solution (0.5 ml) of acetic acid (5-25%) and capsaicin (100 μg/ml). The nerve activity was augmented by colonic instillation of capsaicin to a greater extent in rats with DSS-induced colitis than in normal control rats. This augmented activity by capsaicin was more prominent at one day (DSS-1) than at 8 day (DSS-8) after the administration of DSS. The increased nerve activity caused by capsaicin in DSS-1 and DSS-8 was significantly inhibited by pretreatment with ruthenium red, which is a nonselective inhibitor of TRP channels of unmyelinated C-fibers (nociceptors). In conclusion, it was elucidated that the nociceptive function of the pelvic nerve was largely elevated at one day after DSS-induced colitis and such increased function was mostly mediated by TRP channels.

  1. Evaluation of changes in serum chemistry in association with feed withdrawal or high dose oral gavage with Dextran Sodium Sulfate (DSS) induced gut leakage in broiler chickens

    Science.gov (United States)

    Dextran sodium sulfate (DSS) has been shown to be effective at inducing enteric inflammation in broiler chickens, resulting in increased leakage of orally administered fluorescein isothiocyanate dextran to circulation. In a previous study, two doses of DSS (0.45g/dose) administered as oral gavage re...

  2. Modelling decision support and uncertainty for large transport infrastructure projects: The CLG-DSS model of the Øresund Fixed Link

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Leleur, Steen; Jensen, Anders Vestergaard

    2007-01-01

    This paper presents a decision support system, named the CLG-DSS model, which makes it possible for decision makers to assess various uncertainties in project appraisal in a systematic and explicit way. This model, a decision support system (DSS) developed within the Danish Centre for Logistics a...

  3. RESULTS OF ANALYSES OF MACROBATCH 3 DECONTAMINATED SALT SOLUTION (DSS) COALESCER AND PRE-FILTERS

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T.; Fondeur, F.; Fink, S.

    2012-06-13

    SRNL analyzed the pre-filter and Decontamination Salt Solution (DSS) coalescer from MCU by several analytical methods. The results of these analyses indicate that overall there is light to moderate solids fouling of both the coalescer and pre-filter elements. The majority of the solids contain aluminum, sodium, silicon, and titanium, in oxide and/or hydroxide forms that we have noted before. The titanium is presumably precipitated from leached, dissolved monosodium titanate (MST) or fines from MST at ARP, and the quantity we find is significantly greater than in the past. A parallel report discusses potential causes for the increased leaching rate of MST, showing that increases in free hydroxide concentration of the feed solutions and of chemical cleaning solutions lead to faster leaching of titanium.

  4. DSS 14 antenna calibrations for GSSR/VLA Saturn radar experiments

    Science.gov (United States)

    Guiar, C. N.; Riggs, R. L.; Stevens, R.; Wert, M.

    1988-01-01

    The DSS 14 pointing and gain were calibrated to support X-band bistatic radar observations of Saturn's rings. The observations used the Goldstone Solar System Radar and the National Radio Astronomy Observatory's Very Large Array (VLA) in Socorro, New Mexico. The pointing calibrations were based on conscan offset data collected during Voyager 1 and 2 support passes. The conscan data show angle-of-arrival sensing with no bias and 0.3 mdeg 1-sigma error. Using the calibrations, demonstrated blind pointing performance on Saturn was less than 3 mdeg 1-sigma error. Meteorological observations at the site were used to reduce elevation errors caused by atmospheric refraction. The techniques used corrected about one-third of the error-poorer than expected performance.

  5. Observations of new western Mediterranean deep water formation using Argo floats 2004–2006

    Directory of Open Access Journals (Sweden)

    K. Stansfield

    2008-05-01

    Full Text Available The deep convection that occurs in the western basin of the Mediterranean Sea was investigated using Argo float data over two consecutive winters in 2004–2005 and 2005–2006. The results showed deep mixed layers reaching 2000 m in surprising locations, namely the eastern Catalan subbasin (39.785° N, 4.845° E and the western Ligurian subbasin (43.392° N, 7.765° E. Subsequently, new deep water was formed in March of 2005 and 2006 with θ=12.89–12.92°C, S=38.48–38.49 and σθ=29.113 kg m−3. The deep water produced in the Ligurian subbasin during 2006 was more saline, warmer and denser than any historical observations of western Mediterranean deep water. The results show S, θ and σθ in the western Mediterranean deep water are higher than 1990s values, with a salinity increase of 1.5×10−3 yr−1, a temperature increase of 3.6×10−3 °C yr−1 and a density increase of 4.0×10−4 kg m−3 yr−1 apparent from a dataset of western Mediterranean deep water properties spanning 1955–2006.

  6. The upper ocean response to tropical cyclones in the northwestern Pacific analyzed with Argo data

    Institute of Scientific and Technical Information of China (English)

    LIU Zenghong; XU Jianping; ZHU Bokang; SUN Chaohui; ZHANG Lifeng

    2007-01-01

    A large number of autonomous profiling floats deployed in global oceans have provided abundant temperature and salinity profiles of the upper ocean. Many floats occasionally profile observations during the passage of tropical cyclones. These in-situ observations are valuable and useful in studying the ocean's response to tropical cyclones, which are rarely observed due to harsh weather conditions. In this paper, the upper ocean response to the tropical cyclones in the northwestern Pacific during 2000-2005 is analyzed and discussed based on the data from Argo profiling floats. Results suggest that the passage of tropical cyclones caused the deepening of mixed layer depth (MLD), cooling of mixed layer temperature (MLT), and freshening of mixed layer salinity (MLS). The change in MLT is negatively correlated to wind speed. The cooling of the MLT extended for 50-150 km on the right side of the cyclone track. The change of MLS is almost symmetrical in distribution on both sides of the track, and the change of MLD is negatively correlated to pre-cyclone initial MLD.

  7. Measurement of the Cosmic Ray Energy Spectrum with ARGO-YBJ

    CERN Document Server

    ,

    2014-01-01

    The ARGO-YBJ detector, located at high altitude in the Cosmic Ray Observatory of Yangbajing in Tibet (4300 m asl, about 600 g/cm2 of atmospheric depth) provides the opportunity to study, with unprecedented resolution, the cosmic ray physics in the primary energy region between 10^{12} and 10^{16} eV. The preliminary results of the measurement of all-particle and light-component (i.e. protons and helium) energy spectra between approximately 5 TeV and 5 PeV are reported and discussed. The study of such energy region is particularly interesting because not only it allows a better understanding of the so called 'knee' of the energy spectrum and of its origin, but also provides a powerful cross-check among very different experimental techniques. The comparison between direct measurements by balloons/satellites and the results by surface detectors, implying the knowledge of shower development in the atmosphere, also allows to test the hadronic interaction models currently used for understanding particle and cosmic ...

  8. Gamma-Ray Flares from Mrk421 in 2008 observed with the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, G

    2009-01-01

    In 2008, the blazar Mrk421 entered in a very active phase and was one of the brightest sources in the sky at TeV energies, showing strong and frequent flaring. We searched for gamma-ray emission at energies E > 0.8 TeV during the whole 2008 with the ARGO-YBJ experiment, a full coverage air shower detector located at Yangbajing (4300 m a.s.l., Tibet, P.R. China). The observed signal is not constant and in correlation with X-ray measurements. The average emission, during the active period of the source, was about twice the Crab Nebula level, with an integral flux of (4.9$\\pm 2.0$)x 10$^{-11}$ photons cm$^{-2}$ s$^{-1}$ for E$_{\\gamma}$ >1 TeV. This paper concentrates on 2008 June when the Mrk421 flaring activity has been studied from optical to 100 MeV gamma rays, and only partially up to TeV energies, since the moonlight hampered the Cherenkov telescope observations after 8 June. Our data complete these observations, with the detection of a second flare of intensity of about 7 Crab units on June 11-13, with a ...

  9. Assessment of Global Oceanic Net Freshwater Flux Products Using Argo Salinity Observations

    Science.gov (United States)

    Ren, L.; Arkin, P. A.; Hackert, E. C.; Busalacchi, A. J.

    2012-12-01

    The annual mean global upper ocean salt budget is investigated using the Argo profiling float data from 2006 to 2011, which provides a way to estimate the annual mean oceanic evaporation and precipitation (E-P) from the ocean salinity. Employing this "ocean rain gauge" concept, E-P estimated from the salt budget is compared with the various satellite based oceanic precipitation and evaporation observational products. In this study, twelve sets of E-P from the evaporation and precipitation products including the precipitation datasets GPCP, CMAP and TRMM and the evaporation datasets OAFlux, GSSTF2b, IFREMER and RSS are compared to the E-P estimated from the salinity. We will describe the spatial patterns of the various E-P products derived from the satellite based data sets and compare these patterns to those derived from the oceanic salinity on the annual mean time scale. We will also examine time series of near-global integrated E-P derived from satellite products and compare them to time series based on oceanic salinity observations as well as continental discharge. This intercomparison of independently derived estimates of fresh water flux at the ocean surface will improve our understanding of errors in remotely sensed estimates of evaporation and precipitation.

  10. Designing a Decision Support System (DSS) for Academic Library Managers Using Preprogrammed Application Software on a Microcomputer.

    Science.gov (United States)

    McDonald, Joseph

    1986-01-01

    Focusing on management decisions in academic libraries, this article compares management information systems (MIS) with decision support systems (DSS) and discusses the decision-making process, information needs of library managers, sources of data, reasons for choosing microcomputer, preprogrammed application software, prototyping a system, and…

  11. Deep structure of crust and the upper mantle of the Mendeleev Rise on the Arktic­-2012 DSS profile

    DEFF Research Database (Denmark)

    Kashubin, Sergey; Petrov, Oleg; Artemieva, Irina;

    2016-01-01

    During high­latitude combined geological and geophysical expedition “Arctic­-2012”, deep seismic sounding (DSS) with ocean bottom seismometers were carried out in the Arctic Ocean along the line 740 km long, crossing the Mendeleev Rise at about 77° N. Crustal and upper mantle Vp­velocity and Vp...

  12. Effect of acute and chronic DSS induced colitis on plasma eicosanoid and oxylipin levels in the rat.

    Science.gov (United States)

    Willenberg, Ina; Ostermann, Annika I; Giovannini, Samoa; Kershaw, Olivia; von Keutz, Anne; Steinberg, Pablo; Schebb, Nils Helge

    2015-07-01

    Eicosanoids and oxylipins are potent lipid mediators involved in the regulation of inflammation. In order to evaluate their role and suitability as biomarkers in colitis, we analyzed their systemic levels in the acute and chronic phase of dextran sulfate sodium (DSS) induced colitis. Male Fischer 344 rats were treated in three cycles with 4% DSS in the drinking water (4 days followed by 10 days recovery) and blood was drawn 3 days prior to the first DSS treatment and on days 4, 11, 32 and 39. Histopathological evaluation of the colon tissue after 42 days showed that the animals developed a mild to severe chronic colitis. Consistently, prostaglandin levels were massively (twofold) elevated in the colonic tissue. LC-MS based targeted metabolomics was used to determine plasma oxylipin levels at the different time points. In the acute phase of inflammation directly after DSS treatment, epoxy-fatty acid (FA), dihydroxy-FA and hydroxy-FA plasma concentrations were uniformly elevated. With each treatment cycle the increase in these oxylipin levels was more pronounced. Our data suggest that in the acute phase of colitis release of polyunsaturated FAs from membranes in the inflamed tissue is reflected by a uniform increase of oylipins formed in different branches of the arachidonic acid cascade. However, during the recovery phases the systemic oxylipin pattern is not or only moderately altered and does not allow to evaluate the onset of chronic inflammation in the colon.

  13. Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice : spinal cord c-Fos expression and behavior

    NARCIS (Netherlands)

    Eijkelkamp, Niels; Kavelaars, Annemieke; Elsenbruch, Sigrid; Schedlowski, Manfred; Holtmann, Gerald; Heijnen, Cobi J.

    2007-01-01

    Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior. Am J Physiol Gastrointest Liver Physiol 293: G749-G757, 2007. First published July 26, 2007; doi:10.1152/ajpgi.00114.2007.During acute and chronic inflammation visceral pain perc

  14. Mangiferin attenuates DSS colitis in mice: Molecular docking and in vivo approach.

    Science.gov (United States)

    Somani, Sahil; Zambad, Shitalkumar; Modi, Ketan

    2016-06-25

    Inflammation, oxidative stress and altered mucosal barrier permeability are potential etiopathological or triggering factors for inflammatory bowel disease (IBD). In this study, the therapeutic potential of Mangiferin was investigated in vivo in mouse model of colitis and also attempts were made to understand mechanistic insights of Mangiferin in IBD. In present study, colitis was induced by administration of 5% DSS for 11 days, followed by 3 days of DSS free period. On day 14, animals were sacrificed and colon tissues were taken for biochemical and histological analysis. Therapeutic treatment with Mangiferin after colitis induction (i.e. day 5) ameliorated symptoms of colitis (presence of blood in stools, body weight loss and diarrhea) as evidenced by reduced DAI score, attenuated the levels of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), myeloperoxidase (MPO). It also decreased the colonic pro-inflammatory mediators tumor necrosis factor (TNF-α), interleukin 1β (IL-1β) levels, matrix metalloproteinase-9 (MMP-9) activity and histopathological score. Molecular docking of Mangiferin against TNF-α and MMP-9 was evaluated using GLIDE software. Mangiferin demonstrated the glide score of -8.04 kcal/mol for TNF-α and -9.97 kcal/mol for MMP-9, which indicated its binding potential with TNF-α and MMP-9. In conclusion, Mangiferin reduces colonic damage in a murine model of colitis, alleviates the oxidative and inflammatory events partly through directly influencing the activity of TNF-α and MMP-9 and therefore might have therapeutic usefulness in the management of inflammatory bowel disease.

  15. Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice.

    Directory of Open Access Journals (Sweden)

    Xiaodi Yang

    Full Text Available BACKGROUND: Many evidences show the inverse correlation between helminth infection and allergic or autoimmune diseases. Identification and characterization of the active helminth-derived products responsible for the beneficial effects on allergic or inflammatory diseases will provide another feasible approach to treat these diseases. METHODS AND FINDINGS: Colitis was induced in C57BL/6 mice by giving 3% DSS orally for 7 days. During this period, the mice were treated daily with the excretory/secretory products from T. spiralis adult worms (AES intraperitoneally. The severity of colitis was monitored by measuring body weight, stool consistency or bleeding, colon length and inflammation. To determine the T. spiralis AES product-induced immunological response, Th1, Th2, Th17 and regulatory cytokine profiles were measured in lymphocytes isolated from colon, mesenteric lymph nodes (MLN, and the spleen of treated mice. The CD4+ CD25+ FOXP3+ regulatory T cells (Tregs were also measured in the spleens and MLN of treated mice. Mice treated with AES significantly ameliorated the severity of the DSS-induced colitis indicated by the reduced disease manifestations, improved macroscopic and microscopic inflammation correlated with the up-regulation of Treg response (increased regulatory cytokines IL-10, TGF-beta and regulatory T cells and down-regulation of pro-inflammatory cytokines (IFN-gamma, IL-6 and IL-17 in the spleens, MLN and colon of treated mice. CONCLUSIONS: Our results provide direct evidences that T. spiralis AES have a therapeutic potential for alleviating inflammatory colitis in mice. This effect is possibly mediated by the immunomodulation of regulatory T cells to produce regulatory and anti-inflammatory cytokines and inhibit pro-inflammatory cytokines.

  16. Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.

    Science.gov (United States)

    Zucker, Stephen D; Vogel, Megan E; Kindel, Tammy L; Smith, Darcey L H; Idelman, Gila; Avissar, Uri; Kakarlapudi, Ganesh; Masnovi, Michelle E

    2015-11-15

    Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS). As VCAM-1 and iNOS are important mediators of tissue injury in the dextran sodium sulfate (DSS) murine model of inflammatory colitis, we examined whether bilirubin prevents colonic injury in DSS-treated mice. Male C57BL/6 mice were administered 2.5% DSS in the drinking water for 7 days, while simultaneously receiving intraperitoneal injections of bilirubin (30 mg/kg) or potassium phosphate vehicle. Disease activity was monitored, peripheral blood counts and serum nitrate levels were determined, and intestinal specimens were analyzed for histological injury, leukocyte infiltration, and iNOS expression. The effect of bilirubin on IL-5 production by HSB-2 cells and on Jurkat cell transendothelial migration also was determined. DSS-treated mice that simultaneously received bilirubin lost less body weight, had lower serum nitrate levels, and exhibited reduced disease severity than vehicle-treated animals. Concordantly, histopathological analyses revealed that bilirubin-treated mice manifested significantly less colonic injury, including reduced infiltration of eosinophils, lymphocytes, and monocytes, and diminished iNOS expression. Bilirubin administration also was associated with decreased eosinophil and monocyte infiltration into the small intestine, with a corresponding increase in peripheral blood eosinophilia. Bilirubin prevented Jurkat migration but did not alter IL-5 production. In conclusion, bilirubin prevents DSS-induced colitis by inhibiting the migration of leukocytes across the vascular endothelium and by suppressing iNOS expression.

  17. Assessing performance of Bayesian state-space models fit to Argos satellite telemetry locations processed with Kalman filtering.

    Science.gov (United States)

    Silva, Mónica A; Jonsen, Ian; Russell, Deborah J F; Prieto, Rui; Thompson, Dave; Baumgartner, Mark F

    2014-01-01

    Argos recently implemented a new algorithm to calculate locations of satellite-tracked animals that uses a Kalman filter (KF). The KF algorithm is reported to increase the number and accuracy of estimated positions over the traditional Least Squares (LS) algorithm, with potential advantages to the application of state-space methods to model animal movement data. We tested the performance of two Bayesian state-space models (SSMs) fitted to satellite tracking data processed with KF algorithm. Tracks from 7 harbour seals (Phoca vitulina) tagged with ARGOS satellite transmitters equipped with Fastloc GPS loggers were used to calculate the error of locations estimated from SSMs fitted to KF and LS data, by comparing those to "true" GPS locations. Data on 6 fin whales (Balaenoptera physalus) were used to investigate consistency in movement parameters, location and behavioural states estimated by switching state-space models (SSSM) fitted to data derived from KF and LS methods. The model fit to KF locations improved the accuracy of seal trips by 27% over the LS model. 82% of locations predicted from the KF model and 73% of locations from the LS model were GPS position. Uncertainty in KF model estimates (5.6 ± 5.6 km) was nearly half that of LS estimates (11.6 ± 8.4 km). Accuracy of KF and LS modelled locations was sensitive to precision but not to observation frequency or temporal resolution of raw Argos data. On average, 88% of whale locations estimated by KF models fell within the 95% probability ellipse of paired locations from LS models. Precision of KF locations for whales was generally higher. Whales' behavioural mode inferred by KF models matched the classification from LS models in 94% of the cases. State-space models fit to KF data can improve spatial accuracy of location estimates over LS models and produce equally reliable behavioural estimates. PMID:24651252

  18. Assessing performance of Bayesian state-space models fit to Argos satellite telemetry locations processed with Kalman filtering.

    Directory of Open Access Journals (Sweden)

    Mónica A Silva

    Full Text Available Argos recently implemented a new algorithm to calculate locations of satellite-tracked animals that uses a Kalman filter (KF. The KF algorithm is reported to increase the number and accuracy of estimated positions over the traditional Least Squares (LS algorithm, with potential advantages to the application of state-space methods to model animal movement data. We tested the performance of two Bayesian state-space models (SSMs fitted to satellite tracking data processed with KF algorithm. Tracks from 7 harbour seals (Phoca vitulina tagged with ARGOS satellite transmitters equipped with Fastloc GPS loggers were used to calculate the error of locations estimated from SSMs fitted to KF and LS data, by comparing those to "true" GPS locations. Data on 6 fin whales (Balaenoptera physalus were used to investigate consistency in movement parameters, location and behavioural states estimated by switching state-space models (SSSM fitted to data derived from KF and LS methods. The model fit to KF locations improved the accuracy of seal trips by 27% over the LS model. 82% of locations predicted from the KF model and 73% of locations from the LS model were <5 km from the corresponding interpolated GPS position. Uncertainty in KF model estimates (5.6 ± 5.6 km was nearly half that of LS estimates (11.6 ± 8.4 km. Accuracy of KF and LS modelled locations was sensitive to precision but not to observation frequency or temporal resolution of raw Argos data. On average, 88% of whale locations estimated by KF models fell within the 95% probability ellipse of paired locations from LS models. Precision of KF locations for whales was generally higher. Whales' behavioural mode inferred by KF models matched the classification from LS models in 94% of the cases. State-space models fit to KF data can improve spatial accuracy of location estimates over LS models and produce equally reliable behavioural estimates.

  19. Calibration of the RPC charge readout in the ARGO-YBJ experiment with the iso-gradient method

    International Nuclear Information System (INIS)

    The ARGO-YBJ experiment is a full coverage array of Resistive Plate Chambers (RPCs) with an active area of 5800 m2. In order to eliminate the response difference of the charge readout from the RPCs, a calibration procedure is carried out with the iso-gradient method. This method also allows the extension of the absolute calibration with the muon telescope including scintillation detectors to all the RPCs in the array. The overall systematic uncertainty in measurements of the number of particles by the RPCs is 10.7%. In general, the method gives results consistent with those from a totally different approach also used in the experiment

  20. Revision of deposition and weathering parameters for the ingestion dose module (ECOSYS) of the ARGOS and RODOS decision support systems

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Nielsen, Sven Poul; Thørring, Håvard;

    2011-01-01

    The ECOSYS model is the ingestion dose model integrated in the ARGOS and RODOS decision support systems for nuclear emergency management. The parameters used in this model have however not been updated in recent years, where the level of knowledge on various environmental processes has increased...... considerably. A Nordic work group has carried out a series of evaluations of the general validity of current ECOSYS default parameters. This paper specifically discusses the parameter revisions required with respect to the modelling of deposition and natural weathering of contaminants on agricultural crops...

  1. Measurement of the cosmic ray all-particle and light-component energy spectra with the ARGO-YBJ experiment

    Directory of Open Access Journals (Sweden)

    De Mitri I.

    2015-01-01

    Full Text Available The ARGO-YBJ detector, located at high altitude in the Cosmic Ray Observatory of YangBaJing in Tibet (4300 m asl, about 600 g/cm2 of atmospheric depth provides the opportunity for the study, with unprecedented resolution, of cosmic ray physics in the primary energy region between 1012 and 1016 eV. Preliminary results of the measurements of the all-particle and light-component (i.e. protons and helium energy spectra between approximately 5 TeV and 5 PeV are reported and discussed.

  2. Experimental Research on Atmospheric Electric Field and Extensive Air Shower Particle Increasing During Thunderstorms with ARGO-YBJ

    Institute of Scientific and Technical Information of China (English)

    XU Bin; ZHANG Ying; JIA Huan-Yu

    2008-01-01

    From April lst to August 14th, 2006, thunderstorms had been recorded at Yangbajing Cosmic Ray Observatory by ARGO-YBJ experiment. This paper analyzed the correlation between atmospheric electric field (AEF) and "scaler mode" counting rate during thunderstorm. Counting rates of multiplicities n = 1,2 were found to have a large increase ( from 1.02% to 9.03% ), while there was few or no changes in those of multiplicities n =3 and n≥4 during the thunderstorms. The counts of different multiplicities had different feedbacks on the violent change of AEF, which showed that their energy and most components were distinguishing.

  3. Sistema de adquisición, almacenamiento y distribución de datos con sistema ARGOS

    OpenAIRE

    Pérez López, Fernando

    2011-01-01

    Proyecto Fin de Carrera del Área de Redes de Computadores de la titulación de Ingeniería Informática. El proyecto versa sobre el desarrollo de un sistema automático de descarga, distribución de datos y transformación de datos de boyas con el sistema ARGOS, así como una aplicación móvil para el sistema operativo móvil iOS, para su uso en dispositivos móviles iPhone.

  4. 基于海温参数模型推算Argo表层温度%Estimation of Argo sea subsurface temperature based on a thermal parametric model

    Institute of Scientific and Technical Information of China (English)

    张春玲; 许建平; 鲍献文; 王振峰; 刘增宏

    2014-01-01

    Argo has become an important part of the global ocean observation system. While, due to the lack of sea surface measurements, application of the Argo data still has some limitations. Based on a simple thermal parametric model,the relationship between sea surface temperature and subsurface temperature was constructed in this paper by the thermal parameters calculated from Argo profile data and WOA09 climatic data. And then sea surface temperature was estimated by Argo subsurface data in the Pacific Ocean. Among them, the thermal parameters were calculated by the maximum angle method. The novel objective method produced the more accurate thermal parameters than those by the iterative technique used in previous studies, such as mixed layer depth, thermocline temperature gradient, thermocline bottom depth and so on. Compared with the SST extrapolated from the traditional method and retrieved from satellite SST,the RMSEs between the estimated Argo surface temperature and the observed GTSPP or Argo NST have been significantly reduced;the correlation coefficient between estimation result and in situ observation was larger as well. The Argo surface temperature estimated by the thermal parametric model in the Pacific Ocean was theoretically proved to be reliable through correlation analysis. This study made up for the lacking of surface observation in Argo. It provided a new way to establish complete Argo data sets.%Argo浮标观测已成为全球海洋观测系统的重要支柱,但因缺乏表层观测,使得Argo观测资料在海洋和大气研究中的应用仍有一定的局限性。基于一个简化的海洋温度参数模型,由Argo剖面观测及气候态数据所确定的垂向海洋温度参数,得到表层与次表层温度的函数关系,进而利用太平洋海域的Argo次表层温度数据来推算表层温度场。其中,海温参数模型的相关参数采用最大角度法求得,利用此方法得到的混合层深度,温跃层梯度,

  5. Decision Support system- DSS- for irrigation management in greenhouses: a case study in Campania Region

    Science.gov (United States)

    Monaco, Eugenia; De Mascellis, Roberto; Riccardi, Maria; Basile, Angelo; D'Urso, Guido; Magliulo, Vincenzo; Tedeschi, Anna

    2016-04-01

    In Mediterranean Countries the proper management of water resources is important for the preservation of actual production systems. The possibility to manage water resources is possible especially in the greenhouses systems. The challenge to manage the soil in greenhouse farm can be a strategy to maintain both current production systems both soil conservation. In Campania region protected crops (greenhouses and tunnels) have a considerable economic importance both for their extension in terms of surface harvested and also for their production in terms of yields. Agricultural production in greenhouse is closely related to the micro-climatic condition but also to the physical and agronomic characteristics of the soil-crop system. The protected crops have an high level of technology compare to the other production systems, but the irrigation management is still carried out according to empirical criteria. The rational management of the production process requires an appropriate control of climatic parameters (temperature, humidity, wind) and agronomical inputs (irrigation, fertilization,). All these factors need to be monitored as well is possible, in order to identify the optimal irrigation schedule. The aim of this work is to implement a Decision Support system -DSS- for irrigation management in greenhouses focused on a smart irrigation control based on observation of the agro-climatic parameters monitored with an advanced wireless sensors network. The study is conducted in a greenhouse farm of 6 ha located in the district of Salerno were seven plots were cropped with rocket. Preliminary a study of soils proprieties was conducted in order to identify spatial variability of the soil in the farm. So undisturbed soil samples were collected to define chemical and physical proprieties; moreover soil hydraulic properties were determined for two soils profiles deemed representation of the farm. Then the wireless sensors, installed at different depth in the soils

  6. Comparison of Data From Far Ultraviolet Limb Scanning and Imaging Instrumentation Aboard the Advanced Research and Global Observation Satellite (ARGOS)

    Science.gov (United States)

    Walker, P. W.; Carruthers, G. R.; Dymond, K. F.; Finch, M. A.; McDonald, S. E.; Nicholas, A. C.; Thonnard, S. E.; Budzien, S. A.; McCoy, R. P.

    2001-05-01

    The ARGOS satellite includes two Naval Research Laboratory experiments that monitor naturally occurring far ultraviolet emissions in the Earth's upper atmosphere. Coincident observations between these two instruments, the Global Imaging Monitor of the Ionosphere (GIMI) and the Low Resolution Airglow and Auroral Spectrograph (LORAAS), have been obtained. The GIMI instrument produces 9 ° x 9 ° limb images with passband coverage between 131 and 200 nm. The LORAAS instrument provides the spectral distribution from 80 to 170 nm for 2.4 ° x 17 ° field of regard. The two instruments are coaligned aboard the spacecraft, aft-looking in the orbital plane. Preliminary comparisons of observations obtained from the imaging and scanning instruments under quiet geomagnetic conditions are reported, including irradiances and spectral distributions. By combining the GIMI data with that from LORAAS, the study of the dynamics of the ionosphere can be expanded to investigate both horizontal and vertical distrubutions and their variances. The improved capability can extend to the study of active periods with highly variable and disturbed ionospheres, and examples are discussed from data acquired during periods of high geomagnetic activity. These results provide the first direct comparison between near simultaneous limb scans and images from ARGOS, and show promise as a validation technique to improve capabilities for the study of ionospheric variability.

  7. Implementation of position assimilation for ARGO floats in a realistic Mediterranean Sea OPA model and twin experiment testing

    Directory of Open Access Journals (Sweden)

    V. Taillandier

    2006-05-01

    Full Text Available In this paper, a Lagrangian assimilation method is presented and implemented in a realistic OPA OGCM with the goal of providing an assessment of the assimilation of realistic Argo float position data. We focus on an application in the Mediterranean Sea, where in the framework of the MFSTEP project an array of Argo floats have been deployed with parking depth at 350 m and sampling interval of 5 days. In order to quantitatively test the method, the ''twin experiment'' approach is followed and synthetic trajectories are considered. The method is first tested using ''perfect'' data, i.e. without shear drift errors and with relatively high coverage. Results show that the assimilation is effective, correcting the velocity field at the parking depth, as well as the velocity profiles and the geostrophically adjusted mass field. We then consider the impact of realistic datasets, which are spatially sparse and characterized by shear drift errors. Such data provide a limited global correction of the model state, but they efficiently act on the location, intensity and shape of the described mesoscale structures of the intermediate circulation.

  8. An Ensemble Recentering Kalman Filter with an Application to Argo Temperature Data Assimilation into the NASA GEOS-5 Coupled Model

    Science.gov (United States)

    Keppenne, Christian L.

    2013-01-01

    A two-step ensemble recentering Kalman filter (ERKF) analysis scheme is introduced. The algorithm consists of a recentering step followed by an ensemble Kalman filter (EnKF) analysis step. The recentering step is formulated such as to adjust the prior distribution of an ensemble of model states so that the deviations of individual samples from the sample mean are unchanged but the original sample mean is shifted to the prior position of the most likely particle, where the likelihood of each particle is measured in terms of closeness to a chosen subset of the observations. The computational cost of the ERKF is essentially the same as that of a same size EnKF. The ERKF is applied to the assimilation of Argo temperature profiles into the OGCM component of an ensemble of NASA GEOS-5 coupled models. Unassimilated Argo salt data are used for validation. A surprisingly small number (16) of model trajectories is sufficient to significantly improve model estimates of salinity over estimates from an ensemble run without assimilation. The two-step algorithm also performs better than the EnKF although its performance is degraded in poorly observed regions.

  9. Observation of TeV gamma rays from the Cygnus region with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bleve, C; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Cattaneo, C; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2012-01-01

    We report the observation of TeV gamma-rays from the Cygnus region using the ARGO-YBJ data collected from 2007 November to 2011 August. Several TeV sources are located in this region including the two bright extended MGRO J2019+37 and MGRO J2031+41. According to the Milagro data set, at 20 TeV MGRO J2019+37 is the most significant source apart from the Crab Nebula. No signal from MGRO J2019+37 is detected by the ARGO-YBJ experiment, and the derived flux upper limits at 90% confidence level for all the events above 600 GeV with medium energy of 3 TeV are lower than the Milagro flux, implying that the source might be variable and hard to be identified as a pulsar wind nebula. The only statistically significant (6.4 standard deviations) gamma-ray signal is found from MGRO J2031+41, with a flux consistent with the measurement by Milagro.

  10. Long-term monitoring of the TeV emission from Mrk 421 with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bleve, C; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cappa, A; Cardarelli, R; Catalanotti, S; Cattaneo, C; Celio, P; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Galeotti, P; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Qu, X B; Rossi, E; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yan, Y X; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2011-01-01

    ARGO-YBJ is an air shower detector array with a fully covered layer of resistive plate chambers. It is operated with a high duty cycle and a large field of view. It continuously monitors the northern sky at energies above 0.3 TeV. In this paper, we report a long-term monitoring of Mrk 421 over the period from 2007 November to 2010 February. This source was observed by the satellite-borne experiments Rossi X-ray Timing Explorer and Swift in the X-ray band. Mrk 421 was especially active in the first half of 2008. Many flares are observed in both X-ray and gamma-ray bands simultaneously. The gamma-ray flux observed by ARGO-YBJ has a clear correlation with the X-ray flux. No lag between the X-ray and gamma-ray photons longer than 1 day is found. The evolution of the spectral energy distribution is investigated by measuring spectral indices at four different flux levels. Hardening of the spectra is observed in both X-ray and gamma-ray bands. The gamma-ray flux increases quadratically with the simultaneously measur...

  11. Analyses of phenotype and ARGOS and ASY1 expression in a ploidy Chinese cabbage series derived from one haploid.

    Science.gov (United States)

    Gu, Ai Xia; Zhao, Jian Jun; Li, Li Min; Wang, Yan Hua; Zhao, Yu Jing; Hua, Fan; Xu, Yuan Chao; Shen, Shu Xing

    2016-03-01

    The aim of this research was to improve our understanding of how ploidy level influences phenotype and gene expression in Chinese cabbage (Brassica rapa L. ssp. pekinensis). Haploid plants (2n = 10) was induced by 0.2% colchicine to produce diploid (2n = 20) and tetraploid plants (2n = 40). The aneuploid (2n = 24) was also obtained by hybridization between diploid plants as the female and tetraploid plants. The ploidy levels of all plants were identified through chromosome counts and flow cytometry. Leaves and petals became larger as the ploidy level increased from haploid to diploid, and from aneuploid to tetraploid. Similarly, expression of ARGOS was regulated by genome size, increasing in parallel with the level of ploidy. Among the four ploidy types, expression was stronger in the floral buds than in the leaves. Expression by ASY1 also differed according to ploidy level, being highest in diploid plants, followed in order by tetraploids. Expression was similar between haploids and aneuploids at two stages-prior to and after meiosis-but was higher in the haploids during meiosis. When buds were compared within the same ploidy type at different stages, ASY1 expression was obviously higher during meiosis than either before or after. Our study demonstrated the generation and phenotype of a ploidy Chinese cabbage series derived from one haploid. Expression of genes ARGOS and ASY1 were modulated by genome size in this ploidy series, and the regulated patterns of the two genes was different. PMID:27162487

  12. Direct measurements of surface and mid-depth circulation in the Shikoku Basin by Argo profiling floats

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hui; GUO Peifang; XU Jianping; SHI Maochong

    2007-01-01

    The circulation in the Shikoku Basin plays a very important role in the pathway of the Kuroshio and the water exchange in the subtropical gyre in the North Pacific Ocean. The Argo profiling floats deployed in the Shikoku Basin are used to study the circulations and water masses in the basin. The trajectories and parking depth velocity fields derived from all Argo floats show an anticyclonic circulation at 2 000 m in the Shikoku Basin. There are inhanced eddy activities in the Shikoku Basin, which have large influence on the Shikoku Basin circulation patterns. The characteristics of temperature - salinity curves indicate that there are North Pacific Ocean tropical water (NPTW), North Pacific Ocean subtropical mode water (NPSTMW) and North Pacific Ocean intermediate water (NPIW) in the Shikoku Basin. The NPTW is only exists south of 32°N. In the middle part of the basin, which is 28°~31°N,133°~135°E, there is a confluence region. Water masses coming from the Kuroshio mix with the water in the Shikoku Basin.

  13. Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis.

    Science.gov (United States)

    Massafra, Vittoria; Ijssennagger, Noortje; Plantinga, Maud; Milona, Alexandra; Ramos Pittol, José M; Boes, Marianne; van Mil, Saskia W C

    2016-02-01

    Inflammatory Bowel Disease (IBD) is a multifactorial disorder involving dysregulation of the immune response and bacterial translocation through the intestinal mucosal barrier. Previously, we have shown that activation of the bile acid sensor Farnesoid X Receptor (FXR), which belongs to the family of nuclear receptors, improves experimental intestinal inflammation, decreasing expression of pro-inflammatory cytokines and protecting the intestinal barrier. Here, we aimed to investigate the immunological mechanisms that ameliorate colitis when FXR is activated. We analyzed by FACS immune cell populations in mesenteric lymph nodes (MLN) and in the spleen to understand whether FXR activation alters the systemic immune response. We show that FXR activation by obeticholic acid (OCA) has systemic anti-inflammatory effects that include increased levels of plasma IL-10, inhibition of both DSS-colitis associated decrease in splenic dendritic cells (DCs) and increase in Tregs. Impact of OCA on DC relative abundance was seen in spleen but not MLN, possibly related to the increased FXR expression in splenic DCs compared to MLN DCs. Moreover, FXR activation modulates the chemotactic environment in the colonic site of inflammation, as Madcam1 expression is decreased, while Ccl25 is upregulated. Together, our data suggest that OCA treatment elicits an anti-inflammatory immune status including retention of DCs in the spleen, which is associated with decreased colonic inflammation. Pharmacological FXR activation is therefore an attractive new drug target for treatment of IBD. PMID:26554605

  14. Decision Support System (DSS) for MSMA Integrated Stormwater Management Ecohydrology for Sustainable Green Infrastructure

    Science.gov (United States)

    Sidek, L. M.; Mohiyaden, H. A.; Haris, H.; Basri, H.; Muda, Z. C.; Roseli, Z. A.; Norlida, M. D.

    2016-03-01

    Rapid urbanization has known to have several adverse impacts towards hydrological cycle due to increasing impervious surface and degradation of water quality in stormwater runoff. In the past, urban waterways have been confined to narrow river corridors with the channels canalised and concrete and other synthetic materials forming the bed and banks of the river. Apart from that, stormwater pollutants such as litter, debris and sediments in drainage system are common problems that can lead to flooding and the degradation of water quality. To solve this problem, implementing stormwater Best Management Practices (BMPs) proves very promising due to its near natural characteristics and multiple effects on the drainage of stormwater runoff in urban areas. This judgment of using BMPs depends on not only relevant theoretical considerations, but also a large amount of practical experience and the availability of relevant data, as well. To fulfil this task, the so-called Decision Support System (DSS) in MSMA Design Aid and Database system are able to assist engineers and developers in management and improvement of water quantity and quality entering urban rivers from urban regions. This system is also helpful when an expert level judgment procure some repetitive and large amount of cases, like in the planning of stormwater BMPs systems for an entire city catchment. One of the advantages of an expert system is that it provides automation of expert-level judgement using availability of checking tools system.

  15. DSS中数据开采技术的研究%Study of Data Mining Technologies in DSS

    Institute of Scientific and Technical Information of China (English)

    周瑛

    2003-01-01

    决策支持系统(DSS)是信息研究的最新发展阶段,已成为计算机应用领域中的重要研究课题.本文详细阐述了DSS中数据开采的三种主要技术,并提出了数据开采的发展方向.

  16. Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines.

    Science.gov (United States)

    Urushima, Hayato; Nishimura, Junichi; Mizushima, Tsunekazu; Hayashi, Noriyuki; Maeda, Kazuhisa; Ito, Toshinori

    2015-01-01

    Anti-inflammatory effects have been reported in Perilla frutescens leaf extract (PE), which is a plant of the genus belonging to the Lamiaceae family. We examined the effect of PE on dextran sulfate sodium (DSS)-induced colitis. Preliminarily, PE was safely administered for 7 wk without any adverse effects. In the preventive protocol, mice were fed 1.5% DSS solution dissolved in distilled water (control group) or 0.54% PE solution (PE group) ad libitum for 7 days. In the therapeutic protocol, distilled water or 0.54% PE solution was given for 10 days just after administration of 1.5% DSS for 5 days. PE intake significantly improved body weight loss. The serum cytokine profile demonstrated that TNF-α, IL-17A, and IL-10 were significantly lower in the PE group than in the control group. In the therapeutic protocol, mice in the PE group showed significantly higher body weight and lower histological colitis scores compared with mice in the control group on day 15. The serum cytokine profile demonstrated that TGF-β was significantly higher in the PE group than in the control group. In distal colon mRNA expression, TNF-α, and IL-17A were significantly downregulated. In vitro analyses of biologically active ingredients, such as luteolin, apigenin, and rosmarinic acid, in PE were performed. Luteolin suppressed production of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-17A. Apigenin also suppressed secretion of IL-17A and increased the anti-inflammatory cytokine IL-10. Rosmarinic acid increased the regulatory T cell population. We conclude that PE might be useful in treatment and prevention of DSS-induced colitis.

  17. Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice.

    Science.gov (United States)

    Zhang, Yinzhong; Brenner, Max; Yang, Weng-Lang; Wang, Ping

    2015-05-01

    Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive system and typically requires lifelong medical care. Recombinant human MFG-E8 (rhMFG-E8) is a 364-amino acid protein, which promotes apoptotic cell clearance and reduces inflammation. This study investigates the therapeutic effect of rhMFG-E8 on two well-established mouse models of IBD. Acute mucosal injury leading to colitis was caused by exposing C57BL/6 mice to 4% dextran sodium sulfate (DSS) in the drinking water over 7 days, and BALB/c mice to a single intrarectal dose of 2.75 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Upon clinical onset of colitis (day 2 in the DSS model and day 1 in the TNBS model), mice were treated with daily subcutaneous injections of rhMFG-E8 (60 or 120 μg/kg/day) or vehicle (saline) for 6 days. Treatment with rhMFG-E8 significantly attenuated colitis in both models in a dose-dependent way. Treatment of DSS-induced colitis with rhMFG-E8 (120 μg/kg/day) decreased weight loss by 59%, the colitis severity score by 71%, and colon shrinkage by 49% when compared with vehicle. Similarly, treatment of TNBS-induced colitis with rhMFG-E8 (120 μg/kg/day) decreased weight loss by 97%, the colitis severity score by 82%, and colon shrinkage by 62% when compared with vehicle. In both models, the colons of animals receiving rhMFG-E8 showed marked reduction in neutrophil infiltration, cytokine and chemokine expression, and apoptotic cell counts. In conclusion, rhMFG-E8 ameliorates DSS- and TNBS-induced colitis, suggesting that it has the potential to become a novel therapeutic agent for IBD.

  18. Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines.

    Science.gov (United States)

    Urushima, Hayato; Nishimura, Junichi; Mizushima, Tsunekazu; Hayashi, Noriyuki; Maeda, Kazuhisa; Ito, Toshinori

    2015-01-01

    Anti-inflammatory effects have been reported in Perilla frutescens leaf extract (PE), which is a plant of the genus belonging to the Lamiaceae family. We examined the effect of PE on dextran sulfate sodium (DSS)-induced colitis. Preliminarily, PE was safely administered for 7 wk without any adverse effects. In the preventive protocol, mice were fed 1.5% DSS solution dissolved in distilled water (control group) or 0.54% PE solution (PE group) ad libitum for 7 days. In the therapeutic protocol, distilled water or 0.54% PE solution was given for 10 days just after administration of 1.5% DSS for 5 days. PE intake significantly improved body weight loss. The serum cytokine profile demonstrated that TNF-α, IL-17A, and IL-10 were significantly lower in the PE group than in the control group. In the therapeutic protocol, mice in the PE group showed significantly higher body weight and lower histological colitis scores compared with mice in the control group on day 15. The serum cytokine profile demonstrated that TGF-β was significantly higher in the PE group than in the control group. In distal colon mRNA expression, TNF-α, and IL-17A were significantly downregulated. In vitro analyses of biologically active ingredients, such as luteolin, apigenin, and rosmarinic acid, in PE were performed. Luteolin suppressed production of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-17A. Apigenin also suppressed secretion of IL-17A and increased the anti-inflammatory cytokine IL-10. Rosmarinic acid increased the regulatory T cell population. We conclude that PE might be useful in treatment and prevention of DSS-induced colitis. PMID:25359539

  19. Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB.

    Science.gov (United States)

    Chen, Xi; Liu, Xi-shuang

    2016-03-01

    This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 μmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.

  20. Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.

    Science.gov (United States)

    Yin, Jie; Wu, Miaomiao; Duan, Jielin; Liu, Gang; Cui, Zhijie; Zheng, Jie; Chen, Shuai; Ren, Wenkai; Deng, Jinping; Tan, Xiangwen; Al-Dhabi, Naif Abdullah; Duraipandiyan, Veeramuthu; Liao, Peng; Li, Tiejun; Yulong, Yin

    2015-12-01

    Inflammatory bowel disease (IBD) correlates with oxidative stress, inflammation, and alteration in several signal pathways, including nuclear transcription factor-kappaB (NF-κB). Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB, has been widely demonstrated to exhibit an antioxidant and anti-inflammatory function. This study aimed to test the hypothesis that NF-κB inhibitor PDTC confers a beneficial role in a colitis model induced by dextran sodium sulfate (DSS) in mouse. The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppressed the expression of antioxidant enzymes and tight junctions, and activated NF-κB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathways. PDTC significantly upregulated (P DSS-induced colitis model. Meanwhile, PDTC reversed (P DSS treatment. In conclusion, PDTC could serve as an adjuvant therapy for the patient with IBD.

  1. β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.

    Science.gov (United States)

    Schippers, A; Muschaweck, M; Clahsen, T; Tautorat, S; Grieb, L; Tenbrock, K; Gaßler, N; Wagner, N

    2016-03-01

    Leukocyte recruitment is pivotal for the initiation and perpetuation of inflammatory bowel disease (IBD) and controlled by the specificity and interactions of chemokines and adhesion molecules. Interactions of the adhesion molecules α4β7-integrin and mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) promote the accumulation of pathogenic T-cell populations in the inflamed intestine. We aimed to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of IBD. We demonstrate that β7-integrin deficiency protects recombination-activating gene-2 (RAG-2)-deficient mice from dextran sodium sulfate (DSS)-induced colitis and coincides with decreased numbers of colonic effector monocytes. We also show that β7-integrin is expressed on most CD11b(+)CD64(low)Ly6C(+) bone marrow progenitors and contributes to colonic recruitment of these proinflammatory monocytes. Importantly, adoptive transfer of CD115(+) wild-type (WT) monocytes partially restored the susceptibility of RAG-2/β7-integrin double-deficient mice to DSS-induced colitis, thereby demonstrating the functional importance of β7-integrin-expressing monocytes for the development of DSS colitis. We also reveal that genetic ablation of MAdCAM-1 ameliorates experimental colitis in RAG-2-deficient mice as well. In summary, we demonstrate a previously unknown role of α4β7-integrin-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  2. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation.

    Science.gov (United States)

    Liu, Xiaowei; He, Haiyue; Huang, Tingting; Lei, Zhen; Liu, Fuquan; An, Guangyu; Wen, Tao

    2016-01-01

    Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protect against experimental colitis through modulation of neutrophils. We induced colitis in C57BL/6 mice by giving 3% dextran sulfate sodium (DSS) orally, and meanwhile, we treated mice daily with Tanshinone IIA intraperitoneally. The severity of colitis was evaluated by calculating disease activity index (DAI) and histological parameters. Neutrophil infiltration and activation in the colons of mice were measured. Moreover, whether Tanshinone IIA has direct effects on neutrophil migration and activation was determined in vitro. Our data showed that Tanshinone IIA significantly ameliorated the severity of DSS-induced colitis in mice, evidenced by the reduced DAI and improved colonic inflammation. In addition, Tanshinone IIA decreased neutrophil infiltration of intestinal mucosa and activation and reduced colonic inflammatory cytokines in DSS-treated mice. Furthermore, Tanshinone IIA was demonstrated to significantly suppress neutrophil migration and activation. These results provide compelling evidence that Tanshinone IIA has a therapeutic potential for alleviating inflammatory colitis in mice, which is possibly mediated by the immunomodulation of neutrophils.

  3. Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS).

    Science.gov (United States)

    Pang, Tikki; Cardosa, Mary Jane; Guzman, Maria G

    2007-01-01

    The past four decades has witnessed a consolidation of the original observations made in the 1970s that dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) have an immunological basis. Following reinfection with a dengue virus of different serotype, severe disease is linked to high levels of antibody-enhanced viral replication early in illness which is followed by a cascade of memory T-cell activation and a 'storm' of inflammatory cytokines and other chemical mediators. These compounds are released mainly from T cells, monocytes/macrophages and endothelial cells, and ultimately cause an increase in vascular permeability. The consolidation of the evidence has been largely due to several important prospective sero-epidemiological studies in areas endemic for DHF/DSS, which have shown that risk of severe disease is significantly higher in secondary dengue infections. These advances have underscored the fact that DHF/DSS pathogenesis is a complex, multifactorial process involving cocirculation of various dengue virus serotypes and the interplay of host and viral factors that influence disease severity. The continued search to define risk factors in susceptible populations must be combined with the new techniques of molecular virology and innovative approaches in vaccine design to achieve the ultimate objective of developing a safe and effective vaccine. PMID:17130899

  4. Interpretation of Postmodern Feminism in Argo%《逃离德黑兰》的后现代女性主义解读

    Institute of Scientific and Technical Information of China (English)

    张乔源

    2015-01-01

    作为一部惊心动魄、扣人心弦的政治大片,《逃离德黑兰》充斥着浓烈的美国式个人英雄主义和爱国主义。然而爱国主义主旋律的背后却也隐藏着不可磨灭的男权印记。基于后现代女性主义,从男性话语霸权、两性二元对立思维模式以及女性内部的异化和压迫等三个方面着手,分析《逃离德黑兰》中的男权色彩。%As one of the most impressive political films, Argo is filled with American individual heroism and patriotism.However, be-hind the cover of patriotism, Argo reflects the patriarchal society and male chauvinism.Based on Postmodern Feminism, this paper at-tempts to analyze Argo from the perspective of the discourse hegemony of male, gender dichotomy as well as the internal alienation and oppression of female, so as to reflect the patriarchy in Argo.

  5. Computer Based ex-ante Evaluation of the Planned Railway Line between Copenhagen and Ringsted by use of a Decision Support System named COSIMA-DSS

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Landex, Alex

    2006-01-01

    This paper presents an appraisal study concerning the extension of the main railway line between Copenhagen and Ringsted by use of a software system named COSIMA-DSS. The modelling system is based upon a multi-methodological approach combining a cost-benefit analysis together with a multi......, results from the calculations using COSIMA-DSS are presented and discussed on the basis of a newly developed Danish manual on transport appraisal....

  6. An upper ocean response to Typhoon Bolaven analyzed with Argo profiling floats

    Institute of Scientific and Technical Information of China (English)

    LIU Zenghong; XU Jianping; SUN Chaohui; WU Xiaofen

    2014-01-01

    In situ observations from Argo profiling floats combined with satellite retrieved SST and rain rate are used to investigate an upper ocean response to Typhoon Bolaven from 20 through 29 August 2012. After the passage of Typhoon Bolaven, the deepening of mixed layer depth (MLD), and the cooling of mixed layer temperature (MLT) were observed. The changes in mixed layer salinity (MLS) showed an equivalent number of increasing and decreasing because the typhoon-induced salinity changes in the mixed layer were influenced by precipi-tation, evaporation, turbulent mixing and upwelling of thermocline water. The deepening of the MLD and the cooling of the MLT indicated a significant rightward bias, whereas the MLS was freshened to the left side of the typhoon track and increased on the other side. Intensive temperature and salinity profiles observed by Iridium floats make it possible to view response processes in the upper ocean after the passage of a typhoon. The cooling in the near-surface and the warming in the subsurface were observed by two Iridium floats located to the left side of the cyclonic track during the development stage of the storm, beyond the radius of maxi-mum winds relative to the typhoon center. Water salinity increases at the base of the mixed layer and the top of the thermocline were the most obvious change observed by those two floats. On the right side of the track and near the typhoon center when the typhoon was intensified, the significant cooling from sea surface to a depth of 200×104 Pa, with the exception of the water at the top of the thermocline, was observed by the other Iridium float. Owing to the enhanced upwelling near the typhoon center, the water salinity in the near-surface increased noticeably. The heat pumping from the mixed layer into the thermocline induced by downwelling and the upwelling induced by the positive wind stress curl are the main causes for the different temperature and salinity variations on the different sides of the

  7. Variation of Indo-Pacific upper ocean heat content during 2001–2012 revealed by Argo

    Institute of Scientific and Technical Information of China (English)

    WU Xiaofen; LIU Zenghong; LIAO Guanghong; WU Lingjuan

    2015-01-01

    Understanding of the temporal variation of oceanic heat content (OHC) is of fundamental importance to the prediction of climate change and associated global meteorological phenomena. However, OHC characteristics in the Pacific and Indian oceans are not well understood. Based on in situ ocean temperature and salinity profiles mainly from the Argo program, we estimated the upper layer (0–750 m) OHC in the Indo-Pacific Ocean (40°S–40°N, 30°E–80°W). Spatial and temporal variability of OHC and its likely physical mechanisms are also analyzed. Climatic distributions of upper-layer OHC in the Indian and Pacific oceans have a similar saddle pattern in the subtropics, and the highest OHC value was in the northern Arabian Sea. However, OHC variabilities in the two oceans were different. OHC in the Pacific has an east-west see-saw pattern, which does not appear in the Indian Ocean. In the Indian Ocean, the largest change was around 10°S. The most interesting phenomenon is that, there was a long-term shift of OHC in the Indo-Pacific Ocean during 2001–2012. Such variation coincided with modulation of subsurface temperature/salinity. During 2001–2007, there was subsurface cooling (freshening) nearly the entire upper 400 m layer in the western Pacific and warming (salting) in the eastern Pacific. During 2008–2012, the thermocline deepened in the western Pacific but shoaled in the east. In the Indian Ocean, there was only cooling (upper 150 m only) and freshening (almost the entire upper 400 m) during 2001–2007. The thermocline deepened during 2008–2012 in the Indian Ocean. Such change appeared from the equator to off the equator and even to the subtropics (about 20°N/S) in the two oceans. This long-term change of subsurface temperature/salinity may have been caused by change of the wind field over the two oceans during 2001–2012, in turn modifying OHC.

  8. Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.

    Science.gov (United States)

    Velasquez, Clara Vasquez; Roman, Arthur Dessi; Lan, Nguyen Thi Phuong; Huy, Nguyen Tien; Mercado, Edelwisa Segubre; Espino, Fe Esperanza; Perez, Ma Lucila M; Huong, Vu Thi Que; Thuy, Tran Thi; Tham, Vo Dinh; Nga, Cao Thi Phi; Ha, Tran Thi Ngoc; Bilar, Josie M; Bajaro, Jemimah Dawn P; Baello, Benilda Q; Kikuchi, Mihoko; Yasunami, Michio; Morita, Kouichi; Watanabe, Naohiro; Karbwang, Juntra; Hirayama, Kenji

    2015-05-01

    We previously reported, significantly higher levels of Chymase and Tryptase in early stage plasma of DSS patients prior to the occurrence of shock suggesting a possible role of mast cells in dengue pathogenesis. To further investigate, we analyzed CMA1 promoter SNP (rs1800875) and TPSAB1 gene alleles, which encode the Human Chymase and α- and β- tryptase 1 enzymes respectively, for susceptibility to Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in patients from hospitals in Vietnam (Ho Chi Minh City and Vinh Long) and the Philippines. While the CMA1 promoter SNP (rs1800875) was not associated with DHF/DSS, the homozygous form of α-tryptase allele was associated with DSS patients in Vinh Long and the Philippines (OR=3.52, pDSS were combined in Vinh Long (OR=1.5, p=0.034) and the Philippines (OR=2.36, p=0.0004); in Ho Chi Minh City when DHF and DSS were combine an association was observed, but it was not statistically significant (OR=1.5, p=0.0505). Therefore, the α-tryptase might have a possible effect on the susceptibility to severe form of Dengue infection.

  9. Investigation of wind erosion process for estimation, prevention, and control of DSS in Yazd-Ardakan plain.

    Science.gov (United States)

    Ekhtesasi, M R; Sepehr, A

    2009-12-01

    Wind erosion is a phenomenon that is reasonably common in regions where dry winds blow. For the most part, these regions correspond to the dry lands; areas where the soil, generally, is dry and shifting and lacks vegetation for most of the year. The winds are sufficiently strong to lift and move sands and soil particles. The repeated removal of superficial layers by the action of winds can modify the texture of the topsoil, by removing the fine particles and leaving the larger particles. Dust and sandstorm (DSS) is the generic term for a serious environmental phenomenon that involves strong winds that blow a large quantity of dust and fine sand particles away from the ground and carry them over a long distance with significant environmental impacts along the way. In the realm of DSS in Iran country, the people who live in Yazd and Sistan-Baluchestan provinces form a single ecological community due to their geographic proximity and climatic contiguity. The major sources of DSS in the region are believed to be the desert and semidesert areas of the Yazd-Ardakan plain in Yazd province. Both Sistan and Baluchestan are the recipients of this dust. To address the long-range transboundary environmental problem of DSS, a regional cooperation mechanism must be established among the provinces in the region. Yazd-Ardakan plain, with area of about 650,000 ha, is located in the center of Iran, between Yazd and Ardakan cities. The mean annual rainfall is less than 65 mm. Rainfall distribution is a simple modal and more than 70% of it occurs in winter. Plant density varies from 0% to 25%, and Artemisia sieberi is the dominant plant species. The major part of Yazd-Ardakan plain is bare land. According to the recent investigation, more than 20,000-m(3) dust with less than 100-microm diameter falls down annually on Yazd city with an area of 7,000 ha. Horizontal visibility is reduced to less than 6 m in stormy days in some parts of Yazd-Ardakan plain. This phenomenon causes car

  10. Using GPS data to evaluate the accuracy of state-space methods for correction of Argos satellite telemetry error.

    Science.gov (United States)

    Patterson, Toey A; McConnell, Bernie J; Fedak, Mike A; Bravington, Mark V; Hindell, Mark A

    2010-01-01

    Recent studies have applied state-space models to satellite telemetry data in order to remove noise from raw location estimates and infer the true tracks of animals. However, while the resulting tracks may appear plausible, it is difficult to determine the accuracy of the estimated positions, especially for position estimates interpolated to times between satellite locations. In this study, we use data from two gray seals (Halichoerus grypus) carrying tags that transmitted Fastloc GPS positions via Argos satellites. This combination of Service Argos data and highly accurate GPS data allowed examination of the accuracy of state-space position estimates and their uncertainty derived from satellite telemetry data. After applying a speed filter to remove aberrant satellite telemetry locations, we fit a continuous-time Kalman filter to estimate the parameters of a random walk, used Kalman smoothing to infer positions at the times of the GPS measurements, and then compared the filtered telemetry estimates with the actual GPS measurements. We investigated the effect of varying maximum speed thresholds in the speed-filtering algorithm on the root mean-square error (RMSE) estimates and used minimum RMSE as a criterion to guide the final choice of speed threshold. The optimal speed thresholds differed between the two animals (1.1 m/s and 2.5 m/s) and retained 50% and 65% of the data for each seal. However, using a speed filter of 1.1 m/s resulted in very similar RMSE for both animals. For the two seals, the RMSE of the Kalman-filtered estimates of location were 5.9 and 12.76 km, respectively, and 75% of the modeled positions had errors less than 6.25 km and 11.7 km for each seal. Confidence interval coverage was close to correct at typical levels (80-95%), although it tended to be overly generous at smaller sizes. The reliability of uncertainty estimates was also affected by the chosen speed threshold. The combination of speed and Kalman filtering allows for effective

  11. Temperature and salinity profiles from CTD casts from the ARGOS and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 November 1989 to 30 November 1989 (NODC Accession 8900297)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the ARGOS and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  12. Effects of interannual salinity variability on the dynamic height in the western equatorial Pacific as diagnosed by Argo

    Institute of Scientific and Technical Information of China (English)

    ZHENG Fei; WANG Hui; WAN Liying

    2015-01-01

    In this paper, interannual variations of the ocean dynamic height over the tropical Pacific are diagnosed using three-dimensional temperature and salinity fields from Argo profiles, with a focus on the effects of interannually varying salinity on the El Ni(n)o-Southern Oscillation (ENSO) evolutions. The diagnostic analyses clearly demonstrate a significant and large role that the salinity field plays in modulating the sea surface dynamic height (SSDH) in the western tropical Pacific. In particular, the contribution of the interannually varying salinity to the interannual variations in SSDH approximately equals to that of the interannually varying temperature. Over the western equatorial Pacific, the salinity variability was responsible for a 30% to 40% reduction in SSDH anomaly in opposition to the thermal build up in SSDH anomaly, providing an important contribution to modulating the seasonal-to-interannual evolution of the tropical Pacific Ocean and affecting the developing of ENSO events.

  13. Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17.

    Science.gov (United States)

    Sun, Yan; Lin, Lian-Jie; Lin, Yan; Sang, Li-Xuan; Jiang, Min; Zheng, Chang-Qing

    2015-01-01

    This study explored the underlying mechanism of Gingko biloba extract (Ginaton) on dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. 40 male C57BL/6 mice were randomly divided into four groups: normal control group, Ginaton group, Ginaton treatment group, and DSS group. After 7 days administration, mice were sacrificed and colons were collected for H-E staining, immunohistochemistry, real-time PCR and Western blot. By observing clinical disease activity and histological damage, we assessed the effect of Ginaton on DSS-induced acute experimental colitis in mice and observed the effect of Ginaton on normal mice. We also explored the specific mechanism of Ginaton on DSS-induced acute experimental colitis in mice through examining the expression of inflammatory related mediators (gp130, STAT3, p-STAT3, ROR-γt) and cytokines (IL-6, IL-17, IL-23). Ginaton-treated DSS mice showed significant improvement over untreated DSS mice. Specifically, Ginaton improved clinical disease activity (DAI score, weight closs, colon shortening, and bloody stool) and histological damage, and reduced the expression of inflammatory-related mediators (p-STAT3, gp130, ROR-γt) and cytokines (IL-6, IL-17, IL-23). In addition, clinical disease activity, histological damage, the expression of inflammatory related mediators (STAT3, p-STAT3, gp130, ROR-t) and cytokines (IL-6, IL-17, IL-23) in mice of Ginaton group were similar to normal control group. In conclusion, Ginaton ameliorates DSS-induced acute experimental colitis in mice by reducing IL-17 production, which is at least partly involved in inhibiting IL-6/STAT3 signaling pathway and IL-23/IL-17 axis. Moreover, Ginaton itself does not cause inflammatory change in normal mice. These results support that Ginaton can be as a potential clinical treatment for ulcerative colitis (UC).

  14. Using MicroLEIS DSS to evaluate climate change impacts on land suitability in Andalusia, Spain

    Science.gov (United States)

    Kotb Abd-Elmabod, Sameh; Anaya-Romero, María; Jordán, Antonio; Muñoz-Rojas, Miriam; de la Rosa, Diego

    2013-04-01

    Understanding the effects of climate change on land suitability for crop production has become an important issue with respect to food security in areas undergoing increasing population sizes. Land suitability for six common Mediterranean crops was evaluated under current conditions and future climate change scenario. This evaluation was performed using the Agro-ecological Decision Support System Micro LEIS (MicroLEIS DSS) through the application of Terraza and Cervatana models. Terraza model provides an experimental prediction for the bioclimatic deficiency in the 62 natural regions that represent the Andalusia region. This model is dependent on current climate data, future climate change scenario data, and crop response data including coefficient of photosynthetic efficacy (Kc), coefficient of efficiency (Ky), and soil water retention. Alternatively, the Cervatana model is used to estimate agricultural land use capability under different soil types. Soil morphological and analytical data were collected from SEISnet data base representative of the natural region (NUTS 2) of Andalusia by 62 soil profiles. Agro-climatic data, referred to temperature and precipitation were obtained from the CDBm-Andalusia database, which contains monthly average values of climate variables: mean temperature, maximum and minimum rainfall, number of days of rain and humidity, collected during a consecutive period of 30 years (1960-1990), that represent the current climate scenario. Future climate is represented under A1B scenario for theperiods 2040, 2070 and 2100. These scenarios have been calculated using climate change variation values from the State Meteorological Agency (AEMET, 2011). The results of the Cervatana model depends on Terraza output results (e.g. water deficit class and the risk of frost class) and other land properties including soil factors, slope factors, and erosion risk factors. In order to spatialize the evaluation data, both models were incorporated into a

  15. The electrical conductivities of the DSS-13 beam-waveguide antenna shroud material and other antenna reflector surface materials

    Science.gov (United States)

    Otoshi, T. Y.; Franco, M. M.; Reilly, H. F., Jr.

    1992-01-01

    A significant amount of noise temperature can potentially be generated by currently unknown dissipative losses in the beam waveguide (BWG) shroud. The amount of noise temperature contribution from this source is currently being studied. In conjunction with this study, electrical conductivity measurements were made on samples of the DSS-13 BWG shroud material at 8.420 GHz. The effective conductivities of unpainted and painted samples of the BWG shroud were measured to be 0.01 x 10(exp 7) and 0.0036 x 10(exp 7) mhos/m, respectively. This value may be compared with 5.66 x 10(exp 7) mhos/m for high conductivity copper.

  16. COSIMA-DSS Evaluation System: A new Decision Support System for Large-Scale Transport Infrastructure Projects

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Jensen, Anders Vestergaard; Leleur, Steen

    2005-01-01

    This paper presents a new decision support model COSIMA-DSS that examines socio-economic feasibility risks involved in the implementation of transport infrastructure projects. The model makes use of conventionally cost-benefit analysis embedded within a wider multi-criteria analysis. The basic...... approach set out in the paper looks upon the mix between so-called “hard” and “soft” evaluation criteria. Finally, a Monte-Carlo simulation is used to take account of the varying information relating to the different criteria....

  17. LandCaRe DSS--an interactive decision support system for climate change impact assessment and the analysis of potential agricultural land use adaptation strategies.

    Science.gov (United States)

    Wenkel, Karl-Otto; Berg, Michael; Mirschel, Wilfried; Wieland, Ralf; Nendel, Claas; Köstner, Barbara

    2013-09-01

    Decision support to develop viable climate change adaptation strategies for agriculture and regional land use management encompasses a wide range of options and issues. Up to now, only a few suitable tools and methods have existed for farmers and regional stakeholders that support the process of decision-making in this field. The interactive model-based spatial information and decision support system LandCaRe DSS attempts to close the existing methodical gap. This system supports interactive spatial scenario simulations, multi-ensemble and multi-model simulations at the regional scale, as well as the complex impact assessment of potential land use adaptation strategies at the local scale. The system is connected to a local geo-database and via the internet to a climate data server. LandCaRe DSS uses a multitude of scale-specific ecological impact models, which are linked in various ways. At the local scale (farm scale), biophysical models are directly coupled with a farm economy calculator. New or alternative simulation models can easily be added, thanks to the innovative architecture and design of the DSS. Scenario simulations can be conducted with a reasonable amount of effort. The interactive LandCaRe DSS prototype also offers a variety of data analysis and visualisation tools, a help system for users and a farmer information system for climate adaptation in agriculture. This paper presents the theoretical background, the conceptual framework, and the structure and methodology behind LandCaRe DSS. Scenario studies at the regional and local scale for the two Eastern German regions of Uckermark (dry lowlands, 2600 km(2)) and Weißeritz (humid mountain area, 400 km(2)) were conducted in close cooperation with stakeholders to test the functionality of the DSS prototype. The system is gradually being transformed into a web version (http://www.landcare-dss.de) to ensure the broadest possible distribution of LandCaRe DSS to the public. The system will be continuously

  18. Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity.

    Science.gov (United States)

    Zhang, H L; Zheng, Y J; Pan, Y D; Xie, C; Sun, H; Zhang, Y H; Yuan, M Y; Song, B L; Chen, J F

    2016-03-01

    Integrin α4β7 controls lymphocyte trafficking into the gut and has essential roles in inflammatory bowel disease (IBD). The α4β7-blocking antibody vedolizumab is approved for IBD treatment; however, high dose of vedolizumab aggravates colitis in a small percentage of patients. Herein, we show that integrin β7 deficiency results in colonic regulatory T (Treg) cell depletion and exacerbates dextran sulfate sodium (DSS) colitis by evoking aberrant innate immunity. In DSS-treated β7-deficient mice, the loss of colonic Treg cells induces excessive macrophage infiltration in the colon via upregulation of colonic epithelial intercellular adhesion molecule 1 and increases proinflammatory cytokine expression, thereby exacerbating DSS-induced colitis. Moreover, reconstitution of the colonic Treg cell population in β7-deficient mice suppresses aberrant innate immune response in the colon and attenuates DSS colitis. Thus, integrin α4β7 is essential for suppression of DSS colitis as it regulates the colonic Treg cell population and innate immunity.

  19. Analysis on the characteristics of sound speed in the northern South China Sea based on Argo data%基于Argo观测资料的南海北部海域声速场时空特征分析

    Institute of Scientific and Technical Information of China (English)

    张伟涛; 张韧; 王辉瓒; 安玉柱; 陈建; 段志刚

    2013-01-01

    Based on the Argo profile data of nearly 5 years,the spatial-temporal variation characteristics of sound speed profiles in northern South China Sea were analyzed by Empirical Orthogonal Function (EOF),and then the sound speed characteristics for different depths were obtained by interpolating the scattered Argo sound speed data into regular gridded data.The results were shown as follows:The first 1-6 modes reflected the main features of the sound speed structure.The first mode,with an obvious year cycle,was closely related to the mixed layer.The second mode,with a phase contrary to the first mode,mainly worked in the subsurface.The third mode mainly affected the layers beneath the subsurface.The horizontal distributions of sound speed were different at each depth,and the sound speed at surface was notably influenced by water temperature while the sound speed below the surface was closely relative to the circulation system and water mass displacement.Cold eddy caused low sound speed zones.Both the Luzon cold eddy and the Vietnam cold eddy caused low sound speed zones.%利用近5年的Argo剖面序列,通过经验正交函数(EOF)分析,分析了南海北部海域声速垂直结构的时空变化特征和声速场水平分布特征.分析表明:EOF的前6个模态反映了海区声速结构的主要变化,可以很好地表示声速剖面.第1模态具有明显的年变化周期,主要受海洋混合层季节性变化影响;第2模态与第1模态时间函数具有明显的反向变化特征,主要对次表层进行调制;第3模态主要影响次表层以下声速变化;表层声速分布与深层声速分布有明显的差异,表层声速主要受海水温度变化的影响,深层声速分布与南海环流系统关系密切;冷涡的存在会引起声速场的低值中心.

  20. Understanding Legacy Features with Featureous

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    Java programs called Featureous that addresses this issue. Featureous allows a programmer to easily establish feature-code traceability links and to analyze their characteristics using a number of visualizations. Featureous is an extension to the NetBeans IDE, and can itself be extended by third...

  1. A new species in the genus Pseudorhyncomyia Peris, 1952 and the identity of P. deserticola Zumpt and Argo, 1978 (Diptera, Rhiniidae).

    Science.gov (United States)

    Rognes, Knut

    2013-01-01

    The genus Pseudorhyncomyia Peris, 1952 is re-described and shown to have two valid species: P. braunsi (Villeneuve, 1920) and P. aethiopica sp. nov. The latter is described on the basis of a single male specimen captured near Ado, Ethiopia, in 1953. Nominal species P. deserticola Zumpt and Argo, 1978 is transferred to Zumba Peris, 1951, where it is placed as a junior synonym of Z. antennalis (Villeneuve, 1929), syn. nov.

  2. The use of AQUATOOL DSS applied to the System of Environmental-Economic Accounting for Water (SEEAW)

    Science.gov (United States)

    Pedro-Monzonís, María; Jiménez-Fernández, Pedro; Solera, Abel; Jiménez-Gavilán, Pablo

    2016-02-01

    Currently, water accounts are one of the next steps to be implemented in European River Basin Management Plans. Building water accounts is a complex task, mainly due to the lack of common European definitions and procedures. For their development, when data is not systematically measured, simulation models and estimations are necessary. The main idea of this paper is to present a new approach which enables the combined use of hydrological models and water resources models developed with AQUATOOL Decision Support System (DSS) to fill in the physical water supply and use tables and the asset accounts presented in the System of Economic and Environmental Accounts for Water (SEEAW). The case study is the Vélez River Basin, located in the southern part of the Iberian Peninsula in Spain. In addition to obtaining the physical water supply and use tables and the asset accounts in this river basin, we present here the indicators as a result thereof. These indicators cover many critical aspects of water management, showing a general description of the river basin and allowing decision-makers to characterise the pressures on water resources. As a general conclusion, the union of AQUATOOL DSS and SEEAW will provide more complete information to decision-makers and it enables to introduce these methodological decisions in order to guarantee consistency and comparability of the results between different river basins.

  3. Conjugation, number of Dewar resonance structures (DSs) in homologous polyzethrene and related conjugated polycyclic hydrocarbon series, and kinked versus straight

    Science.gov (United States)

    Dias, Jerry Ray

    2015-11-01

    Kinked polyzethrenes are more stable than linear polyzethrenes making them better candidates as materials for organic electronic devices (e.g., organic field effect transistors, nonlinear optics, and semiconductors) because of their greater singlet biradical properties. For series of molecules constructed by successive attachment of a given aufbau unit, we are able to derive analytical or recursion expressions relating certain properties. For example, starting with a few known number of Dewar resonance structures (DSs) for such a series, one is often able to derive analytical or recursion expressions for these DS values by our method of successive differences which then lead to either constant or Fibonacci numbers, respectively. The increasing order of π-electronic stability of isomers with the same number of Kekulé structures (K) is determined by their increasing number of DSs. Kinked polycyclic conjugated polyenes with a single classical structure (i.e., K = 1) are more conjugated and stable than their straight polycyclic isomers with a single classical structure.

  4. DSS中的数据库管理子系统分析与应用%Analysis and Application of the Database Management Subsystem in DSS

    Institute of Scientific and Technical Information of China (English)

    邹修明; 张岳新

    2001-01-01

    This paper makes a comparison between Decision Support System (DSS) and Management Information System (MIS) on data management. It introduces some of current methods for data management, focussing on an analysis on the composition and architecture of database management subsystem in DSS. Besides, it illustrates , with an example, key problems that should be taken into account during building a data management subsystem in DSS.%文章比较了 DSS与MIS在数据管理上的差异,列出了DSS中常用的几种数据管理方法,重点分析了DSS数据库管理子系统的组成和结构,并结合开发实例,说明了建立DSS数据库管理子系统时应考虑的主要问题。

  5. Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon.

    Science.gov (United States)

    Chen, Menglu; Gao, Lei; Chen, Pan; Feng, Dandan; Jiang, Yalin; Chang, Yongchao; Jin, Jianjun; Chu, Fong-Fong; Gao, Qiang

    2016-01-01

    Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims. To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-induced colitis. Materials and Methods. C57BL/6J (B6) mice were treated with either low-dose (1.0 mg/kg) or high-dose (2.0 mg/kg) 5-HT by enema, low-dose (1.0%) or high-dose (2.5%) DSS, or combined low-dose (1.0%) DSS and (1.0 mg/kg) 5-HT. Mouse colitis was analyzed. MMPs and tissue inhibitors of MMPs (TIMPs) mRNA were measured by real-time quantitative RT-PCR in mouse colon and in human Caco-2 cells and neutrophils. MMP-3 and MMP-9 protein levels were quantified from immunohistochemistry (IHC) images of mouse colons. Results. 5-HT exacerbated DSS-induced colitis, low-dose 5-HT induces both MMP-3 and MMP-9, and high-dose 5-HT only increased MMP-3 mRNA expression in mouse colon. Mouse colon MMP-3 and MMP-9 protein levels were also elevated by 5-HT treatment. The MMP-2, TIMP-1, and TIMP-2 mRNA levels were increased in the inflamed colon. 5-HT induced MMP-3 and MMP-9 mRNA expression in Caco-2 and human neutrophils, respectively, in vitro. Conclusion. 5-HT induced MMP-3 and MMP-9 expression in mouse colon; these elevated MMPs may contribute to DSS-induced colitis.

  6. Surface motility in Pseudomonas sp DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum

    DEFF Research Database (Denmark)

    Andersen, Jens Bo; Koch, Birgit; Nielsen, T.H.;

    2003-01-01

    Pseudomonas sp. DSS73 was isolated from the rhizoplane of sugar beet seedlings. This strain exhibits antagonism towards the root-pathogenic microfungi Pythium ultimum and Rhizoctonia solani. Production of the cyclic lipopeptide amphisin in combination with expression of flagella enables the growing...... bacterial culture to move readily over the surface of laboratory media. Amphisin is a new member of a group of dual-functioning compounds such as tensin, viscosin and viscosinamid that display both biosurfactant and antifungal properties. The ability of DSS73 to efficiently contain root...

  7. How can sludge dewatering devices be assessed? Development of a new DSS and its application to real case studies.

    Science.gov (United States)

    Bertanza, Giorgio; Papa, Matteo; Canato, Matteo; Collivignarelli, Maria Cristina; Pedrazzani, Roberta

    2014-05-01

    A key issue in biological Waste Water Treatment Plants (WWTPs) operation is represented by the sludge management. Mechanical dewatering is a crucial stage for sludge volume reduction; though, being a costly operation, its optimization is required. We developed an original experimental methodology to evaluate the technical (dewatering efficiency) and financial (total treatment costs) performance of dewatering devices, which might be used as a DSS (Decision Support System) for WWTP managers. This tool was then applied to two real case studies for comparing, respectively, three industrial size centrifuges, and two different operation modes of the same machine (fixed installation vs. outsourcing service). In both the cases, the best option was identified, based jointly on economic and (site-specific) technical evaluations. PMID:24603031

  8. Revision of deposition and weathering parameters for the ingestion dose module (ECOSYS) of the ARGOS and RODOS decision support systems

    International Nuclear Information System (INIS)

    The ECOSYS model is the ingestion dose model integrated in the ARGOS and RODOS decision support systems for nuclear emergency management. The parameters used in this model have however not been updated in recent years, where the level of knowledge on various environmental processes has increased considerably. A Nordic work group has carried out a series of evaluations of the general validity of current ECOSYS default parameters. This paper specifically discusses the parameter revisions required with respect to the modelling of deposition and natural weathering of contaminants on agricultural crops, to enable the trustworthy prognostic modelling that is essential to ensure justification and optimisation of countermeasure strategies. New modelling approaches are outlined, since it was found that current ECOSYS approaches for deposition and natural weathering could lead to large prognostic errors. - Highlights: → We examined concepts and parameters in the ECOSYS ingestion dose model. → Natural weathering and deposition processes were studied. → A series of revisions were recommended to users. → Order-of-magnitude errors can be avoided by using the new values.

  9. Objective mapping of Argo data in the Weddell Gyre: a gridded dataset of upper ocean water properties

    Directory of Open Access Journals (Sweden)

    K. A. Reeve

    2015-06-01

    Full Text Available The Weddell Gyre plays a crucial role in the modification of climate by advecting heat poleward to the Antarctic ice shelves and by regulating the density of water masses that feed the lowest limb of the global ocean overturning circulation. However, our understanding of Weddell Gyre water mass properties is limited to regions of data availability, primarily along the Prime Meridian. The aim of this paper is to provide a dataset of the upper water column properties of the entire Weddell Gyre. Objective mapping was applied to Argo float data in order to produce spatially gridded, time composite maps of temperature and salinity for fixed pressure levels ranging from 50 to 2000 dbar, as well as temperature, salinity and pressure at the level of the sub-surface temperature maximum. While the data are currently too limited to incorporate time into the gridded structure, the data are extensive enough to produce maps of the entire region across three time composite periods (2002–2005, 2006–2009 and 2010–2013, which can be used to determine how representative conclusions drawn from data collected along general RV transect lines are on a gyre scale perspective. The work presented here represents the technical prerequisite in addressing climatological research questions in forthcoming studies. These data sets are available in netCDF format at doi:10.1594/PANGAEA.842876.

  10. The Argo Simulation: I. Quenching of Massive Galaxies at High Redshift as a Result of Cosmological Starvation

    CERN Document Server

    Feldmann, Robert

    2014-01-01

    Observations show a prevalence of high redshift galaxies with large stellar masses and predominantly passive stellar populations. A variety of processes have been suggested that could reduce the star formation in such galaxies to observed levels, including quasar mode feedback, virial shock heating, or galactic winds driven by stellar feedback. However, the main quenching mechanisms have yet to be identified. Here we study the origin of star formation quenching using Argo, a cosmological zoom-in simulation that follows the evolution of a massive galaxy at $z\\geq{}2$. This simulation adopts the same sub-grid recipes of the Eris simulations, which have been shown to form realistic disk galaxies, and, in one version, adopts also a mass and spatial resolution identical to Eris. The resulting galaxy has properties consistent with those of observed, massive (M_* ~ 1e11 M_sun) galaxies at z~2 and with abundance matching predictions. Our models do not include AGN feedback indicating that supermassive black holes like...

  11. Quality Controlled Argo Profiling Float Oxygen Data: Open Source Sharing and Version Control Using IPython Notebooks on GitHub

    Science.gov (United States)

    Sakamoto, C.; McCann, M. P.; Plant, J. N.; Johnson, K. S.

    2015-12-01

    Profiling floats equipped with biogeochemical sensors are an ideal platform for observing the seasonal evolution of physical and chemical processes from the surface to the deep interior. As of August 2015, there have reportedly been 765 floats equipped with oxygen sensors with 363 currently active. Although new insights into oceanic biogeochemical processes have come from these data, the profiling oxygen data set has not been fully utilized because the dissolved oxygen data does not undergo QC procedures at the Argo data centers. The oxygen sensors on profiling floats have been demonstrated to produce highly stable and precise data over many months and years but only a small percentage have been verified with discrete samples taken at deployment to determine the sensor accuracy. Takeshita et al (2013) presented a climatology based quality control procedure utilizing the World Ocean Atlas 2009 (WOA09). We used a straightforward approach mentioned in their paper to calculate the sensor gain by comparing the surface %Sat(float) to the surface %Sat(WOA09) using > 1 year of data. We have developed Python scripts to provide QC'd data that are freely available and easily shared using IPython Notebooks hosted on GitHub. We will examine the consistency of the corrected oxygen data set, relative to existing climatologies, and its use in oceanographic studies.

  12. Exclusive Muon-Neutrino Charged Current Muon Plus Any Number of Protons Topologies In ArgoNeuT

    Energy Technology Data Exchange (ETDEWEB)

    Partyka, Kinga Anna [Yale Univ., New Haven, CT (United States)

    2013-01-01

    Neutrinos remain among the least understood fundamental particles even after decades of study. As we enter the precision era o f neutrino measurements bigger and more sophisticated detectors have emerged. The leading candidate among them is a Liquid Argon Time Projection Chamber (LArTPC ) detector technology due to its bubble-like chamber imaging, superb background rejection and scalability. I t is a perfect candidate that w ill aim to answer the remaining questions of the nature o f neutrino and perhaps our existence. Studying neutrinos with a detector that employs detection via beautiful images o f neutrino interactions can be both illuminating and surprising. The analysis presented here takes the full advantage of the LArTPC power by exploiting the first topological analysis of charged current muon neutrino p + N p , muon and any number of protons, interactions with the ArgoNeuT LArTPC experiment on an argon target. The results presented here are the first that address the proton multiplicity at the vertex and the proton kinematics. This study also addresses the importance o f nuclear effects in neutrino interactions. Furthermore, the developed here reconstruction techniques present a significant step forward for this technology and can be employed in the future LArTPC detectors.

  13. Exclusive Muon-Neutrino Charged Current muon plus any number of protons topologies in ArgoNeuT

    Science.gov (United States)

    Partyka, Kinga Anna

    Neutrinos remain among the least understood fundamental particles even after decades of study. As we enter the precision era of neutrino measurements bigger and more sophisticated detectors have emerged. The leading candidate among them is a Liquid Argon Time Projection Chamber (LArTPC) detector technology due to its bubble-like chamber imaging, superb background rejection and scalability. It is a perfect candidate that will aim to answer the remaining questions of the nature of neutrino and perhaps our existence. Studying neutrinos with a detector that employs detection via beautiful images of neutrino interactions can be bath illuminating and surprising. The analysis presented here takes the full advantage of the LArTPC power by exploiting the first topological analysis of charged current muon neutrino mu + Np, muon and any number of protons, interactions with the ArgoNeuT LArTPC experiment on an argon target. The results presented here are the first that address the proton multiplicity at the vertex and the proton kinematics. This study also addresses the importance of nuclear effects in neutrino interactions. Furthermore, the developed here reconstruction techniques present a significant step forward for this technology and can be employed in the future LArTPC detectors.

  14. Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.

    Science.gov (United States)

    Dranse, Helen J; Rourke, Jillian L; Stadnyk, Andrew W; Sinal, Christopher J

    2015-08-01

    Inflammatory bowel disease (IBD) is a family of disorders including ulcerative colitis and Crohn's disease that are characterized by chronic and relapsing intestinal inflammation. Increased production of proinflammatory mediators, possibly combined with low expression of anti-inflammatory mediators, is thought to promote the development and progression of IBD. In the current study, we demonstrate that expression, secretion, and processing of chemerin, a potent chemoattractant for cells expressing chemokine-like receptor 1 (CMKLR1), increased in the cecum and colon along a gradient positively associated with the severity of inflammation in dextran sodium sulfate (DSS)-induced colitis. We also show that levels of circulating bioactive chemerin increased following DSS treatment. At both 6-8 and 14-16 weeks of age, CMKLR1 knockout mice developed signs of clinical illness more slowly than wild type and had changes in circulating cytokine levels, increased spleen weight, and increased local chemerin secretion following DSS treatment. However, knockout mice ultimately developed similar levels of clinical illness and local inflammation as wild type. Finally, contrary to previous reports, intraperitoneal injection of bioactive chemerin had no effect on the severity of DSS-induced colitis. This suggests that local chemerin levels have a greater impact than circulating levels in the pathogenesis of colitis. Considered altogether, bioactive chemerin represents a novel biomarker for IBD severity, although strategies to modulate endogenous chemerin signaling other than chronic CMKLR1 loss are necessary in order to exploit chemerin as a therapeutic target for the treatment of IBD.

  15. Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.

    Science.gov (United States)

    Ledesma-Soto, Yadira; Callejas, Blanca E; Terrazas, César A; Reyes, Jose L; Espinoza-Jiménez, Arlett; González, Marisol I; León-Cabrera, Sonia; Morales, Rosario; Olguín, Jonadab E; Saavedra, Rafael; Oghumu, Steve; Satoskar, Abhay R; Terrazas, Luis I

    2015-01-01

    Chronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB/c and C57BL/6 mice. Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice. Taenia infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced. RT-PCR assays from colon showed that T. crassiceps-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice. The percentages of T regulatory cells were not increased. The adoptive transfer of alternatively activated macrophages (AAMФs) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation. Administration of indomethacin abrogated the anticolitic effect of Taenia. Thus, T. crassiceps infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAMФs and prostaglandins.

  16. Suppression of MAPK and NF-κ B pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease.

    Science.gov (United States)

    Liu, Weidong; Liu, Yang; Wang, Zhi; Yu, Ting; Lu, Qin; Chen, Hong

    2015-09-01

    Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignan isolated from the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill, possesses various biological activities, such as hepatic protection, anti-tumor, anti-inflammatory and anti-cardiovascular properties. However, the effect of Sch B on inflammatory bowel disease (IBD) is not yet known. The aim of this study was to investigate whether Sch B has protective effect against dextran sulfate sodium (DSS)-induced colitis in a mouse model. The acute mouse model of IBD was induced by drinking 2.5% DSS water for 5 days. Sch B was administered orally in doses of 10, 40, and 100 mg/kg respectively. It significantly reduced concentration of TNF-α, IL-1β, INF-γ and IL-6 in colon tissue as well as the mRNA expression levels. In addition, we demonstrated that Sch B blocked the phosphorylation of IκBα, nuclear factor-κB (NF-κB) p65, p38 mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase, and extracellular signal regulated kinase in DSS-induced acute colitis. In conclusion, these results indicated that Sch B could exert beneficial effects on experimental IBD induced by DSS and may represent a novel treatment strategy for IBD.

  17. Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons.

    Science.gov (United States)

    Lv, Qi; Qiao, Si-miao; Xia, Ying; Shi, Can; Xia, Yu-feng; Chou, Gui-xin; Wang, Zheng-tao; Dai, Yue; Wei, Zhi-feng

    2015-12-01

    Norisoboldine (NOR), the main active constituent of Radix Linderae, was previously demonstrated to ameliorate collagen-induced arthritis in rats through regulating the imbalance of T cells in intestines, which implied its therapeutic potential in inflammatory bowel disease. Here, we investigated the effect of NOR on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice. Results showed that NOR (20, 40mg/kg) markedly reduced the symptoms of colitis, the levels of IL-1β and TNF-α, and the activation of ERK, p38 MAPK and NF-κB-p65. NOR only slightly decreased the levels of IFN-γ and IL-17A in mouse colons, but it dramatically increased the level of IL-10 at both protein and mRNA grades. Consistently, NOR increased the number of CD4(+)CD25(+)Foxp3(+) Treg cells more obviously than it decreased that of CD4(+)IL-17(+) Th17 cells in mesenteric lymph nodes (MLNs) and colonic lamina proprias (LPs) of colitis mice, and promoted the expression of Foxp3 mRNA in colon tissues. It could facilitate the in vitro differentiation of Treg cells from naive T cells and promote the phosphorylations of Smad2/3 in colon tissues of colitis mice. On the other hand, NOR did not affect the expressions of homing receptors CCR9 and α4β7 in SPs, and homing ligands CCL25 and Madcam-1 in MLNs and colonic LPs, suggesting that the increase of Treg cells in colons by NOR was not due to gut homing. In conclusion, NOR can ameliorate DSS-induced UC in mice, and the mechanisms involve reduction of pro-inflammatory cytokines and selective induction of Treg cells in colons.

  18. Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.

    Science.gov (United States)

    Deng, Que; Chen, Hongyu; Liu, Yanjun; Xiao, Fengjun; Guo, Liang; Liu, Dan; Cheng, Xiang; Zhao, Min; Wang, Xiaomeng; Xie, Shuai; Qi, Siyong; Yin, Zhaoyang; Gao, Jiangping; Chen, Xintian; Wang, Jiangong; Guo, Ning; Ma, Yuanfang; Shi, Ming

    2016-10-01

    Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition. Psychological stress has been postulated to affect the clinical symptoms and recurrence of IBD. The exact molecular mechanisms are not fully understood. In the present study, we demonstrate that psychological stress promotes neutrophil infiltration into colon tissues in dextran sulfate sodium (DSS)-induced colitis model. The psychological stress resulted in abnormal expression of the proinflammatory cytokines (IL-1β, IL-6, IL-17A, and IL-22) and neutrophil chemokines (CXCL1 and CXCL2) and overactivation of the STAT3 inflammatory signaling pathway. Under chronic unpredictable stress, the adrenergic nervous system was markedly activated, as the expression of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, in bone marrow and colonic epithelium was enhanced, especially in the myenteric ganglia. The β-AR agonist isoproterenol mimicked the effects of psychological stress on neutrophilia, neutrophil infiltration, and colonic damage in DSS-induced colitis. The β1-AR/β2-AR inhibitor propranolol reduced the numbers of the neutrophils in the circulation, suppressed neutrophil infiltration into colonic tissues, and attenuated the colonic tissue damage promoted by chronic stress. Propranolol also abolished stress-induced upregulation of proinflammatory cytokines and neutrophil chemokines. Our data reveal a close linkage between the β1-AR/β2-AR activation and neutrophil trafficking and also suggest the critical roles of adrenergic nervous system in exacerbation of inflammation and damage of colonic tissues in experimental colitis. The current study provides a new insight into the mechanisms underlying the association of psychological stress with excessive inflammatory response and pathophysiological consequences in IBD. The findings also suggest a potential application of neuroprotective agents to prevent relapsing immune activation in the treatment of IBD.

  19. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.

    Science.gov (United States)

    El-Salhy, Magdy; Umezawa, Kazuo

    2016-03-01

    The aim of this study was to determine the effects of two anti-inflammatory agents on the abnormalities in colonic endocrine cells in dextran sodium sulfate (DSS)-induced colitis. Colitis was induced in male Wistar rats (n=45) using DSS; a further 15 rats without colitis were included in a healthy control group. The animals with DSS-induced colitis were randomly divided into 3 treatment groups as follows: i) DSS group, rats were treated with 0.5 ml of 0.5% carboxymethyl cellulose (CMC); ii) DSS‑G group, rats were treated with 3-[(dodecylthiocarbonyl)‑methyl]‑glutarimide (DTCM‑G), a novel activator protein 1 (AP-1) inhibitor, 20 mg/kg in CMC; and iii) DSS‑Q group, rats were treated with dehydroxymethylepoxyquinomicin, a nuclear factor κB (NF-κB) inhibitor, 15 mg/kg in CMC. The treatments were administered intraperitoneally, twice daily for 5 days, after which the animals were sacrificed and tissue samples from the colon were immunostained for chromogranin A (CgA), serotonin, peptide YY (PYY), enteroglucagon, pancreatic polypeptide (PP), somatostatin, leukocytes, B/T lymphocytes, B lymphocytes, T lymphocytes, macrophages/monocytes and mast cells. The densities of these endocrine and immune cells were quantified by computer‑aided image analysis. The densities of CgA-, serotonin-, PYY- and enteroglucagon-producing cells were significantly higher, and those of PP- and somatostatin-producing cells were significantly lower in the DSS‑G, DSS‑Q and control groups than in the DSS group. The densities of all the immune cells were lower in the DSS‑G, DSS‑Q and control groups than in the DSS group. The densities of all endocrine cell types and immune cells in both the DSS groups treated with anti‑inflammatory agents were restored to control levels. In conclusion, our data demonstrate that there is an interaction between endocrine and immune cells during inflammation. This interaction with subsequent changes in endocrine cells is responsible for the

  20. Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis.

    Science.gov (United States)

    Rajendran, Vazhaikkurichi M; Nanda Kumar, Navalpur S; Tse, Chung M; Binder, Henry J

    2015-10-16

    Diarrhea associated with ulcerative colitis (UC) occurs primarily as a result of reduced Na(+) absorption. Although colonic Na(+) absorption is mediated by both epithelial Na(+) channels (ENaC) and Na-H exchangers (NHE), inhibition of NHE-mediated Na(+) absorption is the primary cause of diarrhea in UC. As there are conflicting observations reported on NHE expression in human UC, the present study was initiated to identify whether NHE isoforms (NHE2 and NHE3) expression is altered and how Na(+) absorption is regulated in DSS-induced inflammation in rat colon, a model that has been used to study UC. Western blot analyses indicate that neither NHE2 nor NHE3 expression is altered in apical membranes of inflamed colon. Na(+) fluxes measured in vitro under voltage clamp conditions in controls demonstrate that both HCO3 (-)-dependent and butyrate-dependent Na(+) absorption are inhibited by S3226 (NHE3-inhibitor), but not by HOE694 (NHE2-inhibitor) in normal animals. In contrast, in DSS-induced inflammation, butyrate-, but not HCO3 (-)-dependent Na(+) absorption is present and is inhibited by HOE694, but not by S3226. These observations indicate that in normal colon NHE3 mediates both HCO3 (-)-dependent and butyrate-dependent Na(+) absorption, whereas DSS-induced inflammation activates NHE2, which mediates butyrate-dependent (but not HCO3 (-)-dependent) Na(+) absorption. In in vivo loop studies HCO3 (-)-Ringer and butyrate-Ringer exhibit similar rates of water absorption in normal rats, whereas in DSS-induced inflammation luminal butyrate-Ringer reversed water secretion observed with HCO3 (-)-Ringer to fluid absorption. Lumen butyrate-Ringer incubation activated NHE3-mediated Na(+) absorption in DSS-induced colitis. These observations suggest that the butyrate activation of NHE2 would be a potential target to control UC-associated diarrhea.

  1. Investigation of the physical parameters of duplex stainless steel (DSS surface integrity after turning

    Directory of Open Access Journals (Sweden)

    G. Krolczyk

    2015-01-01

    Full Text Available The article presents the influence of machining parameters on the microhardness of surface integrity (SI after turning by means of a coated sintered carbide wedge with a coating with ceramic intermediate layer. The investigation comprised the influence of cutting speed on the SI microhardness in dry machining. The material under investigation was duplex stainless steel with two-phase ferritic-austenitic structure. The results obtained allow for conclusions concerning the exploitation features of processed machine parts.

  2. Solar Features

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of solar feature datasets contributed by a number of national and private solar observatories located worldwide.

  3. Towards closure of regional heat budgets in the North Atlantic using Argo floats and surface flux datasets

    Directory of Open Access Journals (Sweden)

    N. C. Wells

    2009-04-01

    Full Text Available The upper ocean heat budget (0–300 m of the North Atlantic from 20°–60° N is investigated using data from Argo profiling floats for 1999–2005 and the NCEP/NCAR and NOC surface flux datasets. Estimates of the different terms in the budget (heat storage, advection, diffusion and surface exchange are obtained using the methodology developed by Hadfield et al. (2007a, b. The method includes optimal interpolation of the individual profiles to produce gridded fields with error estimates at a 10°×10° grid box resolution. Closure of the heat budget is obtained within the error estimates for some regions – particularly the eastern subtropical Atlantic – but not for those boxes that include the Gulf Stream. Over the whole range considered, closure is obtained for 13 (9 out of 20 boxes with the NOC (NCEP/NCAR surface fluxes. The seasonal heat budget at 20–30° N, 35–25° W is considered in detail. Here, the NCEP based budget has an annual mean residual of −55±35 Wm−2 compared with a NOC based value of −4±35 Wm−2. For this box, the net heat divergence of 36 Wm−2 (Ekman=−4 Wm−2, geostrophic=11 Wm−2, diffusion=29 Wm−2 offsets the net heating of 32 Wm−2 from the NOC surface heat fluxes. The results in this box are consistent with an earlier evaluation of the fluxes using measurements from research buoys in the subduction array which revealed biases in NCEP but good agreement of the buoy values with the NOC fields.

  4. Towards closure of regional heat budgets in the North Atlantic using Argo floats and surface flux datasets

    Directory of Open Access Journals (Sweden)

    N. C. Wells

    2009-01-01

    Full Text Available The upper ocean heat budget (0–300 m of the North Atlantic from 20°–60° N is investigated using data from Argo profiling floats for 1999–2005 and the NCEP/NCAR and NOC surface flux datasets. Estimates of the different terms in the budget (heat storage, advection, diffusion and surface exchange are obtained using the methodology developed by Hadfield et al. (2007. The method includes optimal interpolation of the individual profiles to produce gridded fields with error estimates at a 10×10 degree grid box resolution. Closure of the heat budget is obtained within the error estimates for some regions – particularly the eastern subtropical Atlantic – but not for those boxes that include the Gulf Stream. Over the whole range considered, closure is obtained for 13 (9 out of 20 boxes with the NOC (NCEP/NCAR surface fluxes. The seasonal heat budget at 20°–30° N, 35°–25° W is considered in detail. Here, the NCEP based budget has an annual mean residual of -55±35 W m-2 compared with a NOC based value of -4±35 W m-2. For this box, the net heat divergence of 36 W m-2 (Ekman=-4 W m-2, geostrophic=11 W m-2, diffusion=29 W m-2 offsets the net heating of 32 W m-2 from the NOC surface heat fluxes. The results in this box are consistent with an earlier evaluation of the fluxes using measurements from research buoys in the subduction array which revealed biases in NCEP but good agreement of the buoy values with the NOC fields.

  5. Detailed temperature–salinity distribution in the Northeast Atlantic from ship and Argo vertical casts

    Directory of Open Access Journals (Sweden)

    I. Bashmachnikov

    2014-06-01

    Full Text Available The present study defines new interpolation functions for hydrological data. These functions are applied to generate climatological maps of temperature–salinity distribution with 25 m depth interval and 30 km space interval (MEDTRANS data-set. The data underwent a rigorous data quality control, having passed several filtering procedures. The gridding was done on neutral density surfaces, which allows better representation of the relative intensity of thermohaline fronts for the same gridding radius. The gridding was done using multi-pass Barnes' Optimum Interpolation procedure with spatially variable size of the gridding window. The shape of the window accounted for topographic influence: the dominant along-slope direction of water mass transport. One of the new features was the use of a local ratio of topographic to planetary β-effects to define the shape of the window as a function of the relative importance of the topographic influence. The N/f ratio was used for simulation of the baroclinic decrease of the topographic influence on water mass transport with the distance from the bottom. The gridded fields are available at the web-site of the Center of Oceanography of the University of Lisbon (http://co.fc.ul.pt/en/data. The new MEDTRANS climatology gives more details to the distribution of water characteristics in the Subtropical Northeast Atlantic, in particular near the Iberian Peninsula. The geostrophic currents relative to the 1900 m reference level demonstrate the local circulation features, in good correspondence to the theory and to previous studies: the acceleration in the meanders of the Azores current; the cyclonic gyre in the Gulf of Cadiz; the splitting and separation of the Mediterranean Water outflow from the continental slope near the Gorringe and the Galicia banks. Those features are not reproduced by the alternative climatologies. Seasonal climatologies, computed for the warm (May–October and cold (November

  6. Bacterial Feeders, the Nematode Caenorhabditis elegans and the Flagellate Cercomonas longicauda, have different Effects on Outcome of Competition among the Pseudomonas Biocontrol Strains CHA0 and DSS73

    DEFF Research Database (Denmark)

    Pedersen, Annette; Nybroe, Ole; Winding, Anne;

    2009-01-01

    selective feeding flagellate Cercomonas longicauda versus the non-selective feeding nematode Caenorhabditis elegans) influence the abundance of two bacteria that compete for resources in simple model communities. Microcosms consisted of either one gfp-tagged bacterial strain (Pseudomonas fluorescens DSM......50090 or one of two biocontrol strains P. fluorescens CHA0 or Pseudomonas sp. DSS73) or combinations of two bacterial strains. DSM50090 is a suitable food bacterium, DSS73 is of intermediate food quality, and CHA0 is inedible to the bacterial feeders. Bacterial and protozoan cell numbers were measured......How bacterial feeding fauna affects colonization and survival of bacteria in soil is not well understood, which constrains the applicability of bacterial inoculants in agriculture. This study aimed to unravel how food quality of bacteria and bacterial feeders with different feeding habits (the...

  7. Sensitivity study of (10,100) GeV gamma-ray bursts with double shower front events from ARGO-YBJ

    Science.gov (United States)

    Zhou, Xun-Xiu; Gao, Lan-Lan; Zhang, Yu; Guo, Yi-Qing; Zhu, Qing-Qi; Jia, Huan-Yu; Huang, Dai-Hui

    2016-07-01

    ARGO-YBJ, located at the Yangbajing Cosmic Ray Observatory (4300 m a.s.l., Tibet, China), is a full coverage air shower array, with an energy threshold of ∼300 GeV for gamma-ray astronomy. Most of the recorded events are single front showers, satisfying the trigger requirement of at least 20 particles detected in a given time window. However, in ∼11.5% of the events, two randomly arriving showers may be recorded in the same time window, and the second one, generally smaller, does not need to satisfy the trigger condition. These events are called double shower front events. By using these small showers, well under the trigger threshold, the detector primary energy threshold can be lowered to a few tens of GeV. In this paper, the angular resolution that can be achieved with these events is evaluated by a full Monte Carlo simulation. The ARGO-YBJ sensitivity in detecting gamma-ray bursts (GRBs) by using double shower front events is also studied for various cutoff energies, time durations, and zenith angles of GRBs in ARGO’s field of view. Supported by National Natural Science Foundation of China (11475141) and Fundamental Research Funds for Central Universities (2682014CX091)

  8. 4.5 years multi-wavelength observations of Mrk 421 during the ARGO-YBJ and Fermi common operation time

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; Damone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q

    2016-01-01

    We report on the extensive multi-wavelength observations of the blazar Markarian 421 (Mrk 421) covering radio to gamma-rays, during the 4.5 year period of ARGO-YBJ and Fermi common operation time, from August 2008 to February 2013. In particular, thanks to the ARGO-YBJ and Fermi data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. In the observation period, Mrk 421 showed both low and high activity states at all wavebands. The correlations among flux variations in different wavebands were analyzed. Seven large flares, including five X-ray flares and two GeV gamma-ray flares with variable durations (3-58 days), and one X-ray outburst phase were identified and used to investigate the variation of the spectral energy distribution with respect to a relative quiescent phase. During the outburst phase and the seven flaring episodes, the peak energy in X-rays is observed to increase from sub-keV to few keV. The TeV gamma-ray flux increases up to 0.9-7.2 times the flux of the Crab Nebula. T...

  9. Observation of TeV gamma-rays from the unidentified source HESS J1841-055 with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Cattaneo, C; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G DAli; DAmone, A; Danzengluobu,; De Mitri, I; Piazzoli, B DEttorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Sbano, S N; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2013-01-01

    We report the observation of a very high energy \\gamma-ray source, whose position is coincident with HESS J1841-055. This source has been observed for 4.5 years by the ARGO-YBJ experiment from November 2007 to July 2012. Its emission is detected with a statistical significance of 5.3 standard deviations. Parameterizing the source shape with a two-dimensional Gaussian function we estimate an extension \\sigma=(0.40(+0.32,-0.22}) degree, consistent with the HESS measurement. The observed energy spectrum is dN/dE =(9.0-+1.6) x 10^{-13}(E/5 TeV)^{-2.32-+0.23} photons cm^{-2} s^{-1} TeV^{-1}, in the energy range 0.9-50 TeV. The integral \\gamma-ray flux above 1 TeV is 1.3-+0.4 Crab units, which is 3.2-+1.0 times the flux derived by HESS. The differences in the flux determination between HESS and ARGO-YBJ, and possible counterparts at other wavelengths are discussed.

  10. Detection of thermal neutrons with the PRISMA-YBJ array in extensive air showers selected by the ARGO-YBJ experiment

    Science.gov (United States)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Stenkin, Yu. V.; Alekseenko, V. V.; Aynutdinov, V.; Cai, Z. Y.; Guo, X. W.; Liu, Y.; Rulev, V.; Shchegolev, O. B.; Stepanov, V.; Volchenko, V.; Zhang, H.

    2016-08-01

    We report on a measurement of thermal neutrons, generated by the hadronic component of extensive air showers (EAS), by means of a small array of EN-detectors developed for the PRISMA project (PRImary Spectrum Measurement Array), novel devices based on a compound alloy of ZnS(Ag) and 6LiF. This array has been operated within the ARGO-YBJ experiment at the high altitude Cosmic Ray Observatory in Yangbajing (Tibet, 4300 m a.s.l.). Due to the tight correlation between the air shower hadrons and thermal neutrons, this technique can be envisaged as a simple way to estimate the number of high energy hadrons in EAS. Coincident events generated by primary cosmic rays of energies greater than 100 TeV have been selected and analyzed. The EN-detectors have been used to record simultaneously thermal neutrons and the air shower electromagnetic component. The density distributions of both components and the total number of thermal neutrons have been measured. The correlation of these data with the measurements carried out by ARGO-YBJ confirms the excellent performance of the EN-detector.

  11. 4.5-year simultaneous multi-wavelength observation of Mrk 421 in the ARGO-YBJ and Fermi overlap era

    CERN Document Server

    Chen, Songzhan

    2015-01-01

    As one of the most active blazars, Mrk421 is an excellent candidate for the study of the physical processes within the jets of AGN. Here we report on the extensive multi-wavelength observations of Mrk 421 over 4.5 years, from 2008 August to 2013 February. This source was simultaneously monitored by several experiments at different wavelengths: ARGO-YBJ in TeV $\\gamma$-rays, $Fermi$-LAT in GeV $\\gamma$-rays, $Swift$-BAT in hard X-rays, $RXTE$-ASM, $MAXI$ and $Swift$-XRT in soft X-rays, $Swift$-UVOT in ultraviolet, and OVRO in radio frequencies. In particular, thanks to the ARGO-YBJ and $Fermi$ data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. According to the observed light curves, ten states (including seven large flares, two quiescent phases and one outburst) were selected. For the first time, the multi-wavelength spectral evolutions of Mrk 421 during different states were systematically analyzed. During the outburst phase and the seven flaring episodes, the peak energy in X-ray...

  12. Evaluating the role of vegetation on the transport of contaminants associated with a mine tailing using the Phyto-DSS

    Energy Technology Data Exchange (ETDEWEB)

    Cano-Resendiz, Omar [Departamento de Ingenieria Quimica, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Rosa, Guadalupe de la, E-mail: delarosa@quijote.ugto.mx [Departamento de Ingenieria Quimica, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Cruz-Jimenez, Gustavo [Departamento de Farmacia, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Gardea-Torresdey, Jorge L. [Chemistry Department and Environmental Science and Engineering, Ph.D. Program, The University of Texas at El Paso, 500 W. University Ave., 79968 El Paso, TX (United States); Robinson, Brett H. [Agriculture and Life Sciences, Lincoln University, P.O. Box 84 Lincoln, Canterbury 7646 (New Zealand)

    2011-05-15

    We identified contaminants associated with the Cata mine tailing depot located in the outskirts of the city of Guanajuato, Mexico. We also investigated strategies for their phytomanagement. Silver and antimony were present at 39 and 31 mg kg{sup -1}, respectively, some twofold higher than the Dutch Intervention Values. Total and extractable boron (B) occurred at concentrations of 301 and 6.3 mg L{sup -1}, respectively. Concentrations of B in soil solution above 1.9 mg L{sup -1} have been shown to be toxic to plants. Plant growth may also be inhibited by the low concentrations of extractable plant nutrients. Analysis of the aerial portions of Aloe vera (L. Burm.f.) revealed that this plant accumulates negligible concentrations of the identified contaminants. Calculations using a whole system model (Phyto-DSS) showed that establishing a crop of A. vera would have little effect on the drainage or leaching from the site. However, this plant would reduce wind and water erosion and potentially produce valuable cosmetic products. In contrast, crops of poplar, a species that is tolerant to high soil B concentrations, would mitigate leaching from this site. Alternate rows of trees could be periodically harvested and be used for timber or bioenergy.

  13. 2-D Crustal thermal structure along Thuadara–Sindad DSS profile across Narmada– Son lineament, central India

    Indian Academy of Sciences (India)

    S N Rai; S Thiagarajan

    2007-08-01

    Central India is traversed by a WSW–ENE trending Narmada–Son lineament (NSL) which is characterized by the presence of numerous hot springs, feeder dykes for Deccan Traps and seismicity all along its length. It is divided in two parts by the Barwani–Sukta Fault (BSF). To the west of this fault a graben exists, whereas to the east the basement is uplifted between Narmada North Fault (NNF) and Narmada South Fault (NSF). The present work deals with the 2-D thermal modeling to delineate the crustal thermal structure of the western part of NSL region along the Thuadara–Sindad Deep Seismic Sounding (DSS) profile which runs almost in the N–S direction across the NSL. Numerical results of the model reveal that the conductive surface heat flow value in the region under consideration varies between 45 and 47mW/m2. Out of which 23mW/m2 is the contribution from the mantle heat flow and the remaining from within the crust. The Curie depth is found to vary between 46 and 47 km and is in close agreement with the earlier reported Curie depth estimated from the analysis of MAGSAT data. The Moho temperature varies between 470 and 500°C. This study suggests that this western part of central Indian region is characterized by low mantle heat flow which in turn makes the lower crust brittle and amenable to the occurrence of deep focused earthquakes such as Satpura (1938) earthquake.

  14. Evaluating the role of vegetation on the transport of contaminants associated with a mine tailing using the Phyto-DSS.

    Science.gov (United States)

    Cano-Reséndiz, Omar; de la Rosa, Guadalupe; Cruz-Jiménez, Gustavo; Gardea-Torresdey, Jorge L; Robinson, Brett H

    2011-05-15

    We identified contaminants associated with the Cata mine tailing depot located in the outskirts of the city of Guanajuato, Mexico. We also investigated strategies for their phytomanagement. Silver and antimony were present at 39 and 31 mg kg(-1), respectively, some twofold higher than the Dutch Intervention Values. Total and extractable boron (B) occurred at concentrations of 301 and 6.3 mg L(-1), respectively. Concentrations of B in soil solution above 1.9 mg L(-1) have been shown to be toxic to plants. Plant growth may also be inhibited by the low concentrations of extractable plant nutrients. Analysis of the aerial portions of Aloe vera (L. Burm.f.) revealed that this plant accumulates negligible concentrations of the identified contaminants. Calculations using a whole system model (Phyto-DSS) showed that establishing a crop of A. vera would have little effect on the drainage or leaching from the site. However, this plant would reduce wind and water erosion and potentially produce valuable cosmetic products. In contrast, crops of poplar, a species that is tolerant to high soil B concentrations, would mitigate leaching from this site. Alternate rows of trees could be periodically harvested and be used for timber or bioenergy.

  15. Discussing a New DSS Combined with Data Warehouse%综合数据仓库的新型决策支持系统

    Institute of Scientific and Technical Information of China (English)

    张新香

    2004-01-01

    本文针对传统DSS(决策支持系统)中存在的问题,提出了一种综合数据仓库的新型DSS框架,并分析其优点,同时介绍了新型DSS在现实中的应用,最后分析了DSS未来的发展趋势.

  16. The Synergic Anti-inflammatory Impact of Gleditsia sinensis Lam. and Lactobacillus brevis KY21 on Intestinal Epithelial Cells in a DSS-induced Colitis Model.

    Science.gov (United States)

    Kim, Younghoon; Koh, Ji Hoon; Ahn, Young Jun; Oh, Sejong; Kim, Sea Hun

    2015-01-01

    We investigated the synergic anti-inflammatory activity of Gleditsia sinensis Lam. (GS) extract and Lactobacillus brevis KY21 both in vitro and in vivo. Western blot analysis and immunostaining showed that AKT phosphorylation that increased by the exposure of LPS were significantly decreased by the presence of either GS extract or L. brevis KY21. In addition, p65 intracellular transport was critically inhibited by GS extract and L. brevis KY21. We further studied these effects using an in vivo dextran sulfate sodium (DSS)-induced mouse model. Body weight, food intake, and clinical scores were dramatically decreased after treatment with DSS, whereas these effects were palliated by the addition of GS extract and L. brevis KY21. Importantly, transcription of genes encoding pro-inflammatory cytokines including IL-1β, TNF-α, and IFN-γ in mesenteric lymph nodes (MLN) and the spleen were increased by DSS treatment, whereas they were inhibited by the presence of GS extract and L. brevis KY21.

  17. MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells.

    Science.gov (United States)

    Pan, Huaqin; Zhang, Guqin; Zhang, Lin; Wang, Wei; Shang, Jian; Wang, Xiaobing; Zhao, Qiu; Li, Jin

    2016-07-01

    Available evidence suggests that both dysregulated innate and adaptive immune pathways contribute to the aberrant intestinal inflammatory response in patients with inflammatory bowel disease (IBD). Myeloid Differentiation 1 (MD-1), also known as Lymphocyte Antigen 86 (Ly86), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signaling pathway. Previous studies showed that MD-1 may be involved in the (patho) physiological regulation of the innate immune system and inflammation. In this study, we reported for the first time that MD-1 mRNA expression was up-regulated in both human IBD patients and DSS-treated WT mice. We showed that MD-1(-/-) mice were less susceptible to the development of colitis than WT controls as demonstrated by significantly reduced weight loss, disease activity index, colon histological scores, cellular infiltration and expression of inflammatory mediators. In addition, mucosal barrier function seemed to be intact in response to the loss of MD-1. Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice. Taken together, our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of DSS colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of IBD.

  18. Aspectos relevantes dos SAD nas organizações: um estudo exploratório Relevant aspects from DSS in organizations: an empirical investigation

    Directory of Open Access Journals (Sweden)

    Adriana Zenaide Clericuzi

    2006-04-01

    Full Text Available A informação vem auxiliando as organizações a alcançarem seus objetivos num ambiente de crescente concorrência, exigindo delas rapidez, flexibilidade e alta percepção. A abrangência cada vez maior do uso dos Sistemas de Apoio à Decisão (SAD como suporte na solução de problemas tem como proposta o processamento de informação para reduzir a incerteza e resolver conflitos. Este artigo tem como objetivo fazer uma investigação sobre os SAD nas organizações brasileiras. Para tal, foi conduzida uma pesquisa exploratória e descritiva, sobre o assunto, foram utilizados questionários que investigaram os SAD nas empresas brasileiras e aspectos relevantes destes sistemas.Information is supporting organizations to reach theirs objectives. Competition is increasing in organizational environment, requiring capability, flexibility and high perception. Decision Support Systems (DSS are becoming greater as a tool for solution of problems, processing information to reduce uncertain in decision problems and deciding conflicts. The objective of this paper is reports a study about DSS in organizations. For such an empirical investigation of literature in DSS and an empirical research were done. Questionnaires had been used to investigate the relevant aspects of SAD in the Brazilian companies.

  19. Ethanol Extract of Cordyceps militaris Grown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS- Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

    Directory of Open Access Journals (Sweden)

    Dong Ki Park

    2013-01-01

    Full Text Available The effect of Cordyceps militaris (CM grown on germinated soybeans (GSC in the inflammatory bowel disease (IBD model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS- induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS and tumor necrosis factor- (TNF- α mRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.

  20. Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice

    Directory of Open Access Journals (Sweden)

    Corthier Gérard

    2007-07-01

    Full Text Available Abstract Background Human immune cells generate large amounts of reactive oxygen species (ROS throughout the respiratory burst that occurs during inflammation. In inflammatory bowel diseases, a sustained and abnormal activation of the immune system results in oxidative stress in the digestive tract and in a loss of intestinal homeostasis. We previously showed that the heterologous production of the Lactobacillus plantarum ATCC14431 manganese-dependant catalase (MnKat in Lb. casei BL23 successfully enhances its survival when exposed to oxidative stress. In this study, we evaluated the preventive effects of this antioxidative Lb. casei strain in a murine model of dextran sodium sulfate (DSS-induced moderate colitis. Results Either Lb. casei BL23 MnKat- or MnKat+ was administered daily to mice treated with DSS for 10 days. In contrast to control mice treated with PBS for which DSS induced bleeding diarrhea and mucosal lesions, mice treated with both Lb. casei strains presented a significant (p Conclusion No contribution of MnKat to the protective effect from epithelial damage has been observed in the tested conditions. In contrast, these results confirm the high interest of Lb. casei as an anti-inflammatory probiotic strain.

  1. Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis

    Directory of Open Access Journals (Sweden)

    Jing-Wei Mao

    2014-01-01

    Full Text Available The immunoregulation between dendritic cells (DCs and regulatory T cells (T-regs plays an important role in the pathogenesis of ulcerative colitis (UC. Recent research showed that Fms-like tyrosine kinase 3 (Flt3 and Flt3 ligand (Flt3L were involved in the process of DCs regulating T-regs. The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC. In this study, we observe the disease activity index (DAI and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis. Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103+MHCII+DCs and CD4+CD25+FoxP3+T-regs in DSS-induced colitis. Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.

  2. The ESPAT tool: a general-purpose DSS shell for solving stochastic optimization problems in complex river-aquifer systems

    Science.gov (United States)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel; Tilmant, Amaury

    2015-04-01

    Stochastic programming methods are better suited to deal with the inherent uncertainty of inflow time series in water resource management. However, one of the most important hurdles in their use in practical implementations is the lack of generalized Decision Support System (DSS) shells, usually based on a deterministic approach. The purpose of this contribution is to present a general-purpose DSS shell, named Explicit Stochastic Programming Advanced Tool (ESPAT), able to build and solve stochastic programming problems for most water resource systems. It implements a hydro-economic approach, optimizing the total system benefits as the sum of the benefits obtained by each user. It has been coded using GAMS, and implements a Microsoft Excel interface with a GAMS-Excel link that allows the user to introduce the required data and recover the results. Therefore, no GAMS skills are required to run the program. The tool is divided into four modules according to its capabilities: 1) the ESPATR module, which performs stochastic optimization procedures in surface water systems using a Stochastic Dual Dynamic Programming (SDDP) approach; 2) the ESPAT_RA module, which optimizes coupled surface-groundwater systems using a modified SDDP approach; 3) the ESPAT_SDP module, capable of performing stochastic optimization procedures in small-size surface systems using a standard SDP approach; and 4) the ESPAT_DET module, which implements a deterministic programming procedure using non-linear programming, able to solve deterministic optimization problems in complex surface-groundwater river basins. The case study of the Mijares river basin (Spain) is used to illustrate the method. It consists in two reservoirs in series, one aquifer and four agricultural demand sites currently managed using historical (XIV century) rights, which give priority to the most traditional irrigation district over the XX century agricultural developments. Its size makes it possible to use either the SDP or

  3. Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-treatment.

    Directory of Open Access Journals (Sweden)

    Asa Håkansson

    Full Text Available Long-term colonic inflammation promotes carcinogenesis and histological abnormalities of the liver, and colorectal tumours frequently arise in a background of dysplasia, a precursor of adenomas. Altered colonic microbiota with an increased proportion of bacteria with pro-inflammatory characteristics, have been implicated in neoplastic progression. The composition of the microbiota can be modified by dietary components such as probiotics, polyphenols and dietary fibres. In the present study, the influence of probiotics in combination with blueberry husks on colorectal carcinogenesis and subsequent liver damage was evaluated.Colorectal tumours were induced in rats by cyclic treatment with dextran sulphate sodium (DSS. Blueberry husks and a mixture of three probiotic strains (Bifidobacterium infantis DSM 15159, Lactobacillus gasseri, DSM 16737 and Lactobacillus plantarum DSM 15313 supplemented a basic diet fortified with oats. The condition of the rats was monitored using a disease activity index (DAI. A qualitative and quantitative histological judgement was performed on segments of distal colon and rectum and the caudate lobe of the liver. The formation of short-chain fatty acids, bacterial translocation, the inflammatory reaction and viable count of lactobacilli and Enterobaceriaceae were addressed.Blueberry husks with or without probiotics significantly decreased DAI, and significantly reduced the number of colonic ulcers and dysplastic lesions. With a decreased proportion of blueberry husk in the diet, the probiotic supplement was needed to achieve a significant decrease in numbers of dysplastic lesions. Probiotics decreased faecal viable count of Enterobacteriaceae and increased that of lactobacilli. Blueberry husks with or without probiotics lowered the proportion of butyric acid in distal colon, and decreased the haptoglobin levels. Probiotics mitigated hepatic injuries by decreasing parenchymal infiltration and the incidence of stasis and

  4. Featuring animacy

    Directory of Open Access Journals (Sweden)

    Elizabeth Ritter

    2015-01-01

    Full Text Available Algonquian languages are famous for their animacy-based grammatical properties—an animacy based noun classification system and direct/inverse system which gives rise to animacy hierarchy effects in the determination of verb agreement. In this paper I provide new evidence for the proposal that the distinctive properties of these languages is due to the use of participant-based features, rather than spatio-temporal ones, for both nominal and verbal functional categories (Ritter & Wiltschko 2009, 2014. Building on Wiltschko (2012, I develop a formal treatment of the Blackfoot aspectual system that assumes a category Inner Aspect (cf. MacDonald 2008, Travis 1991, 2010. Focusing on lexical aspect in Blackfoot, I demonstrate that the classification of both nouns (Seinsarten and verbs (Aktionsarten is based on animacy, rather than boundedness, resulting in a strikingly different aspectual system for both categories. 

  5. The Cosmic Ray p+He energy spectrum in the 3-3000 TeV energy range measured by ARGO-YBJ

    Science.gov (United States)

    Mari, S. M.; Montini, P.

    2016-07-01

    The ARGO-YBJ experiment is a full coverage air shower detector operated at the Yangbajing International Cosmic Ray Observatory. The detector has been in stable data taking in its full configuration since November 2007 to February 2013. The high altitude and the high segmentation and spacetime resolution offer the possibility to explore the cosmic ray energy spectrum in a very wide range, from a few TeV up to the PeV region. The high segmentation allows a detailed measurement of the lateral distribution, which can be used in order to discriminate showers produced by light and heavy elements. In this work we present the measurement of the cosmic ray light component spectrum in the energy range 3-3000 TeV. The analysis has been carried out by using a two-dimensional unfolding method based on the Bayes' theorem.

  6. ARGOS PHWR 380

    International Nuclear Information System (INIS)

    This paper introduces the design of a nuclear power plant of 380 MWe, equipped with a preassure-vessel heavy-water reactor. An explanation is given of the technical, economical and financial factors that led to the design of this medium sized nuclear power plant, which is compatible with the latest advances in the field of nuclear safety. (Author)

  7. DSS FOR ORGANIZATIONAL DIAGNOSIS

    NARCIS (Netherlands)

    FROWEIN, JC; POSTMA, TJBM

    1992-01-01

    Information technology in relation to organizational diagnosis and organizational change is the subject of extensive and increasing discussion. A condition for change is insight into organizational problems. This paper discusses the relation between the concepts ''problem'', ''decision making'' and

  8. DSS in Educational Organizations.

    Science.gov (United States)

    Telem, Moshe

    1990-01-01

    Describes the development of an educational decision support system (EDSS) in Israeli schools. The Israeli educational system is described, the integration of computers into school administration is discussed, the use of management information systems (MIS) is explained, and a structural framework for the implementation of an EDSS is presented.…

  9. MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.

    Science.gov (United States)

    Liu, Wen; Guo, Wenjie; Hang, Nan; Yang, Yuanyuan; Wu, Xuefeng; Shen, Yan; Cao, Jingsong; Sun, Yang; Xu, Qiang

    2016-05-24

    Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-κB) activation, plays an important role in innate and adaptive immunity. Suppression of MALT1 protease activity with small molecule inhibitors showed promising efficacies in subtypes of B cell lymphoma and improvement in experimental autoimmune encephalomyelitis model. However, whether MALT1 inhibitors could ameliorate colitis remains unclear. In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-κB and NLRP3 inflammasome activation. Treatment with MI-2 and mepazine dose-dependently attenuated symptoms of colitis in mice, evidenced by reduction in the elevated disease activity index, the shortening of colon length as well as the histopathologic improvement. Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF, IL-1β, IL-6, IL-18, IL-17A and IFN-γ, were markedly suppressed by MALT1 inhibitors. The underlying mechanisms for the protective effect of MALT1 inhibitors in DSS-induced colitis may be attributed to its inhibition on NF-κB and NLRP3 inflammasome activation in macrophages. The in vitro study showed that MALT1 inhibitors decreased production of IL-1β/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-κB and NLRP3 inflammasome. Taken together, our results demonstrated that inhibition of the protease activity of MALT1 might be a viable strategy to treat inflammatory bowel disease and the NLRP3 inflammasome and NF-κB activation are critical components in MALT1 signaling cascades in this disease model.

  10. Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice.

    Science.gov (United States)

    Sánchez-Fidalgo, Susana; Villegas, Isabel; Aparicio-Soto, Marina; Cárdeno, Ana; Rosillo, Ma Ángeles; González-Benjumea, Alejandro; Marset, Azucena; López, Óscar; Maya, Inés; Fernández-Bolaños, José G; Alarcón de la Lastra, Catalina

    2015-05-01

    Hydroxytyrosol, a polyphenolic compound from extra virgin olive oil (EVOO) has exhibited an improvement in a model of DSS-induced colitis. However, other phenolic compounds present such as hydroxytyrosyl acetate (HTy-Ac) and 3,4-dihydroxyphenylglycol (DHPG) need to be explored to complete the understanding of the overall effects of EVOO on inflammatory colon mucosa. This study was designed to evaluate the effect of both HTy-Ac and DHPG dietary supplementation in the inflammatory response associated to colitis model. Six-week-old mice were randomized in four dietary groups: sham and control groups received standard diet, and other two groups were fed with HTy-Ac and DHPG, respectively, at 0.1%. After 30 days, all groups except sham received 3% DSS in drinking water for 5 days followed by a regime of 5 days of water. Acute inflammation was evaluated by Disease Activity Index (DAI), histology and myeloperoxidase (MPO) activity. Colonic expression of iNOS, COX-2, MAPKs, NF-kB and FOXP3 were determined by western blotting. Only HTy-Ac-supplemented group showed a significant DAI reduction as well as an improvement of histological damage and MPO. COX-2 and iNOS protein expression were also significantly reduced. In addition, this dietary group down-regulated JNK phosphorylation and prevented the DSS-induced nuclear translocation level of p65. However, no significant differences were observed in the FOXP3 expression. These results demonstrated, for the first time, that HTy-Ac exerts an antiinflammatory effect on acute ulcerative colitis. We concluded that HTy-Ac supplement might provide a basis for developing a new dietary strategy for the prevention of ulcerative colitis.

  11. IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice.

    Science.gov (United States)

    Wang, Yuanyuan; Jiang, Xuefeng; Zhu, Junfeng; Dan Yue; Zhang, Xiaoqing; Wang, Xiao; You, Yong; Wang, Biao; Xu, Ying; Lu, Changlong; Sun, Xun; Yoshikai, Yasunobu

    2016-08-22

    Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD is not very clear. In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that IL-21R.KO mice were more susceptible to DSS-induced colitis as compared with C57BL/6 mice. The spontaneous inflammatory cytokines released by macrophages in LP of colon were significantly increased, and Th2, Th17 and Treg responses were down-regulated markedly. However, Th1 responses were significantly up-regulated in IL-21R.KO mice. Meanwhile, the population of CD8(+)CD44(+)IFN-γ(+) T cells was markedly elevated in LP of inflammatory intestine of IL-21RKO mice. In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and Treg responses in mice. Therefore, therapeutic manipulation of IL-21/IL-21R activity may allow improved immunotherapy for IBD and other inflammatory diseases associated with Th cell responses.

  12. IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice.

    Science.gov (United States)

    Wang, Yuanyuan; Jiang, Xuefeng; Zhu, Junfeng; Dan Yue; Zhang, Xiaoqing; Wang, Xiao; You, Yong; Wang, Biao; Xu, Ying; Lu, Changlong; Sun, Xun; Yoshikai, Yasunobu

    2016-01-01

    Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD is not very clear. In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that IL-21R.KO mice were more susceptible to DSS-induced colitis as compared with C57BL/6 mice. The spontaneous inflammatory cytokines released by macrophages in LP of colon were significantly increased, and Th2, Th17 and Treg responses were down-regulated markedly. However, Th1 responses were significantly up-regulated in IL-21R.KO mice. Meanwhile, the population of CD8(+)CD44(+)IFN-γ(+) T cells was markedly elevated in LP of inflammatory intestine of IL-21RKO mice. In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and Treg responses in mice. Therefore, therapeutic manipulation of IL-21/IL-21R activity may allow improved immunotherapy for IBD and other inflammatory diseases associated with Th cell responses. PMID:27545302

  13. Component-based Design and Implementation of DSS' Model%基于组件技术的DSS模型设计与实现

    Institute of Scientific and Technical Information of China (English)

    赵会群; 鄢仁祥; 高远

    2000-01-01

    决策支持系统(DSS)是模型驱动的,DSS中模型的设计与实现是一个有待进一步研究的问题.该文把组件技术引入到DSS模型的设计与实现中,提出基于组件技术的DSS模型设计与实现策略,给出基于组件思想的DSS模型定义和运算,并描述基于组件技术的DSS基模型和复合模型的实现方法.

  14. Effects of natural raw meal (NRM) on high-fat diet and dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice

    OpenAIRE

    Shin, Sung-Ho; Song, Jia-Le; Park, Myoung-Gyu; Park, Mi-Hyun; Hwang, Sung-Joo; Park, Kun-Young

    2015-01-01

    BACKGROUND/OBJECTIVES Colitis is a serious health problem, and chronic obesity is associated with the progression of colitis. The aim of this study was to determine the effects of natural raw meal (NRM) on high-fat diet (HFD, 45%) and dextran sulfate sodium (DSS, 2% w/v)-induced colitis in C57BL/6J mice. MATERIALS/METHODS Body weight, colon length, and colon weight-to-length ratio, were measured directly. Serum levels of obesity-related biomarkers, triglyceride (TG), total cholesterol (TC), l...

  15. The effect of all-trans retinoic acid at varying dose in the treatment of DSS-induced colitis in mice%不同剂量全反式维甲酸对DSS诱导小鼠肠炎的治疗作用

    Institute of Scientific and Technical Information of China (English)

    冯锦山; 邓颖; 杨正; 叶石才; 朱宇珍; 叶营

    2016-01-01

    目的 探讨不同剂量全反式维甲酸(AtRA)对葡聚糖硫酸钠(DSS)诱导结肠炎小鼠的治疗作用.方法 实验小鼠随机分为四组:对照组(Control组),模型组(DSS组),低剂量AtRA(DSS+AtRA-L)组,高剂量AtRA(DSS+AtRA-H)组,每组8只.除Control组外,其他组小鼠自由饮用3%DSS溶液7d诱导结肠炎.DSS+AtRA-L组和DSS+AtRA-H组分别给予AtRA 15 mg/kg和30 mg/kg腹腔注射8~14d.每天记录小鼠改良疾病活动指数(mDAI).第15天处死小鼠,测定各组小鼠结肠长度、结肠组织学评分、血清及结肠组织TNF-α水平.结果DSS+AtRA-H和DSS+AtRA-L组的mDAI和结肠组织学评分较DSS组降低,结肠长度则较DSS组增加,差异均有统计学意义(P<0.01或0.05).DSS+AtRA-H组和DSS+AtRA-L组的黏膜结构改善不明显,其结肠组织学评分高于Control组(P<0.01).DSS+AtRA-H组和DSS+AtRA-L组的TNF-α免疫组化评分比DSS组显著降低(P<0.01),DSS+AtRA-L组高于Control组(P<0.01),但DSS+AtRA-H组与Control组差异无统计学意义(P>0.05).DSS+AtRA-H组和DSS+AtRA-L组的血清TNF-α水平均比DSS组降低(P<0.01),但仍高于Control组(P<0.01).结论AtRA对DSS诱导的小鼠结肠炎有疗效,治疗作用呈剂量依赖关系,但其在肠黏膜结构和结肠缩短方面存在不同程度的局限性.

  16. The bending of the proton plus helium flux in primary cosmic rays measured by the ARGO-YBJ experiment in the energy range from 20 TeV to 5 PeV

    CERN Document Server

    Montini, P

    2016-01-01

    The measurement of proton plus helium and all-particle energy spectra in the range $20\\,$ TeV to $5 \\,$PeV and $80 \\,$TeV to $5 \\,$PeV respectively are presented. Data taken by the ARGO-YBJ detector in the 2010 year have been analyzed. The ARGO-YBJ experiment (Tibet, P. R. China) has been taking data for more than five years by means of a full-coverage array of RPC detectors. The discrimination between showers produced by light and heavy primaries has been performed by looking at the lateral particle density close to the core region. A Bayesian unfolding technique was therefore applied to the measured quantities in order to evaluate the cosmic ray energy spectrum. The proton plus helium spectrum clearly shows a bending at about $1 \\,$PeV, while the all-particle spectrum is consistent with previous observations.

  17. Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice.

    Science.gov (United States)

    Jo, Sung-Gang; Noh, Eui-Jeong; Lee, Jun-Young; Kim, Green; Choi, Joo-Hee; Lee, Mo-Eun; Song, Jung-Hee; Chang, Ji-Yoon; Park, Jong-Hwan

    2016-07-01

    Probiotics such as lactobacilli and bifidobacteria have healthpromoting effects by immune modulation. In the present study, we examined the immunomodulatory properties of Lactobacillus curvatus WiKim38, which was newly isolated from baechu (Chinese cabbage) kimchi. The ability of L. curvatus WiKim38 to induce cytokine production in bone marrow-derived dendritic cells (BMDCs) was determined by enzyme-linked immunosorbent assay. To evaluate the molecular mechanisms underlying L. curvatus Wikim38-mediated IL-10 production, Western blot analyses and inhibitor assays were performed. Moreover, the in vivo anti-inflammatory effects of L. curvatus WiKim38 were examined in a dextran sodium sulfate (DSS)-induced colitis mouse model. L. curvatus WiKim38 induced significantly higher levels of IL-10 in BMDCs compared with that induced by LPS. NF-κB and ERK were activated by L. curvatus WiKim38, and an inhibitor assay revealed that these pathways were required for L. curvatus WiKim38-induced production of IL-10 in BMDCs. An in vivo experiment showed that oral administration of L. curvatus WiKim38 increased the survival rate of mice with DSS-induced colitis and improved clinical signs and histopathological severity in colon tissues. Taken together, these results indicate that L. curvatus Wikim38 may have health-promoting effects via immune modulation, and may thus be applicable for therapy of various inflammatory diseases.

  18. In-Depth Analysis of Exoproteomes from Marine Bacteria by Shotgun Liquid Chromatography-Tandem Mass Spectrometry: the Ruegeria pomeroyi DSS-3 Case-Study

    Directory of Open Access Journals (Sweden)

    Jean Armengaud

    2010-07-01

    Full Text Available Microorganisms secrete into their extracellular environment numerous compounds that are required for their survival. Many of these compounds could be of great interest for biotechnology applications and their genes used in synthetic biology design. The secreted proteins and the components of the translocation systems themselves can be scrutinized in-depth by the most recent proteomic tools. While the secretomes of pathogens are well-documented, those of non-pathogens remain largely to be established. Here, we present the analysis of the exoproteome from the marine bacterium Ruegeria pomeroyi DSS-3 grown in standard laboratory conditions. We used a shotgun approach consisting of trypsin digestion of the exoproteome, and identification of the resulting peptides by liquid chromatography coupled to tandem mass spectrometry. Three different proteins that have domains homologous to those observed in RTX toxins were uncovered and were semi-quantified as the most abundantly secreted proteins. One of these proteins clearly stands out from the catalogue, representing over half of the total exoproteome. We also listed many soluble proteins related to ABC and TRAP transporters implied in the uptake of nutrients. The Ruegeria pomeroyi DSS-3 case-study illustrates the power of the shotgun nano-LC-MS/MS strategy to decipher the exoproteome from marine bacteria and to contribute to environmental proteomics.

  19. The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.

    Science.gov (United States)

    Zou, Z; Zuo, D; Yang, J; Fan, H

    2016-09-01

    Inflammatory bowel disease (IBD) arises when intestinal immune homeostasis is broken, the maintenance of such homeostasis is principally controlled by cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). IECs can prevent the contact between luminal bacteria with immune cells through the formation of a physical barrier and the expression of antimicrobial peptides to maintain intestinal immune homeostasis. During Colitis the IECs can express increased ANXA1, which is important for regeneration of intestinal mucosa and function as a potent anti-inflammatory protein. Natural Killer (NK) cells can also suppress the progression of colitis. It is uncertain about the effect of the cross-talk between injured IECs and recruited NK cells during colitis. In this study, the expression of ANXA1 in IECS from DSS treated mice was increased, and more NK cells were recruited to intestinal mucosa. In addition, the expression of NKG2A was upregulated when co-cultured with NK cells. The results further proved that overexpression of NKG2A in NK cells was important for inhibiting the recruitment and activity of neutrophils to alleviate DSS-induced colitis. Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.

  20. Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice.

    Science.gov (United States)

    Jo, Sung-Gang; Noh, Eui-Jeong; Lee, Jun-Young; Kim, Green; Choi, Joo-Hee; Lee, Mo-Eun; Song, Jung-Hee; Chang, Ji-Yoon; Park, Jong-Hwan

    2016-07-01

    Probiotics such as lactobacilli and bifidobacteria have healthpromoting effects by immune modulation. In the present study, we examined the immunomodulatory properties of Lactobacillus curvatus WiKim38, which was newly isolated from baechu (Chinese cabbage) kimchi. The ability of L. curvatus WiKim38 to induce cytokine production in bone marrow-derived dendritic cells (BMDCs) was determined by enzyme-linked immunosorbent assay. To evaluate the molecular mechanisms underlying L. curvatus Wikim38-mediated IL-10 production, Western blot analyses and inhibitor assays were performed. Moreover, the in vivo anti-inflammatory effects of L. curvatus WiKim38 were examined in a dextran sodium sulfate (DSS)-induced colitis mouse model. L. curvatus WiKim38 induced significantly higher levels of IL-10 in BMDCs compared with that induced by LPS. NF-κB and ERK were activated by L. curvatus WiKim38, and an inhibitor assay revealed that these pathways were required for L. curvatus WiKim38-induced production of IL-10 in BMDCs. An in vivo experiment showed that oral administration of L. curvatus WiKim38 increased the survival rate of mice with DSS-induced colitis and improved clinical signs and histopathological severity in colon tissues. Taken together, these results indicate that L. curvatus Wikim38 may have health-promoting effects via immune modulation, and may thus be applicable for therapy of various inflammatory diseases. PMID:27350616

  1. 基于多Agent的体育训练管理DSS的设计%Design on the physical training and management DSS based on Multi-Agent

    Institute of Scientific and Technical Information of China (English)

    周兴斌; 梅成

    2009-01-01

    根据目前高校体育训练管理中的问题,创建了一个基于Multi-Agent的体育训练管理决策支持系统.它是将Multi-A-gent技术应用到决策支持系统当中,从而有效地提高了系统的准确性和智能性.本文讨论了DSS,Agent和MAS的特点,并通过分析体育管理决策支持系统的功能需求,详细论述了基于Multi-Agent的体育训练管理决策支持系统的总体结构设计、A-gent的具体实现.

  2. Knee of the cosmic hydrogen and helium spectrum below 1 PeV measured by ARGO-YBJ and a Cherenkov telescope of LHAASO

    Science.gov (United States)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Guo, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Bai, Y. X.; Chen, M. J.; Feng, S. H.; Gao, B.; Gu, M. H.; Hou, C.; Liu, J.; Liu, J. L.; Wang, X.; Xiao, G.; Zhang, B. K.; Zhang, S. S.; Zhou, B.; Zuo, X.; ARGO-YBJ Collaboration‡

    2015-11-01

    The measurement of the cosmic ray energy spectrum, in particular for individual species of nuclei, is an important tool to investigate cosmic ray production and propagation mechanisms. The determination of the "knees" in the spectra of different species remains one of the main challenges in cosmic ray physics. In fact, experimental results are still conflicting. In this paper we report a measurement of the mixed proton and helium energy spectrum, obtained with the combined data of the ARGO-YBJ experiment and a wide field of view Cherenkov telescope, a prototype of the future LHAASO experiment. By means of a multiparameter technique, we have selected a high-purity proton plus helium sample. The reconstructed energy resolution is found to be about 25% throughout the investigated energy range from 100 TeV to 3 PeV, with a systematic uncertainty in the absolute energy scale of 9.7%. The found energy spectrum can be fitted with a broken power-law function, with a break at the energy Ek =700 ±230 (stat )±70 (sys ) TeV , where the spectral index changes from -2.56 ±0.05 to -3.24 ±0.36 . The statistical significance of the observed spectral break is 4.2 standard deviations.

  3. A gridded data set of upper-ocean hydrographic properties in the Weddell Gyre obtained by objective mapping of Argo float measurements

    Science.gov (United States)

    Reeve, K. A.; Boebel, O.; Kanzow, T.; Strass, V.; Rohardt, G.; Fahrbach, E.

    2016-02-01

    The Weddell Gyre plays a crucial role in the modification of climate by advecting heat poleward to the Antarctic ice shelves and by regulating the density of water masses that feed the lowest limb of the global ocean overturning circulation. However, our understanding of Weddell Gyre water mass properties is limited to regions of data availability, primarily along the Prime Meridian. The aim of this paper is to provide a data set of the upper water column properties of the entire Weddell Gyre. Objective mapping was applied to Argo float data in order to produce spatially gridded, time-composite maps of temperature and salinity for fixed pressure levels ranging from 50 to 2000 dbar, as well as temperature, salinity and pressure at the level of the sub-surface temperature maximum. While the data are currently too limited to incorporate time into the gridded structure, the data are extensive enough to produce maps of the entire region across three time-composite periods (2001-2005, 2006-2009 and 2010-2013), which can be used to determine how representative conclusions drawn from data collected along general RV transect lines are on a gyre scale perspective. The work presented here represents the technical prerequisite for addressing climatological research questions in forthcoming studies. The data sets are available in netCDF format at doi:10.1594/PANGAEA.842876.

  4. Detection of thermal neutrons with the PRISMA-YBJ array in Extensive Air Showers selected by the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Stenkin, Yu V; Alekseenko, V V; Aynutdinov, V; Cai, Z Y; Guo, X W; Liu, Y; Rulev, V; Shchegolev, O B; Stepanov, V; Volchenko, V; Zhang, H

    2015-01-01

    We report on a measurement of thermal neutrons, generated by the hadronic component of extensive air showers (EAS), by means of a small array of EN-detectors developed for the PRISMA project (PRImary Spectrum Measurement Array), novel devices based on a compound alloy of ZnS(Ag) and 6LiF. This array has been operated within the ARGO-YBJ experiment at the high altitude Cosmic Ray Observatory in Yangbajing (Tibet, 4300 m a.s.l.). Due to the tight correlation between the air shower hadrons and thermal neutrons, this technique can be envisaged as a simple way to get information on the EAS hadronic component, avoiding the use of huge calorimeters. Coincident events generated by primary cosmic rays of energies greater than 100 TeV have been selected and analyzed. The EN-detectors have been used to record simultaneously thermal neutrons and the air shower electromagnetic component. The density distribution of both components and the total number of thermal neutrons have been measured. The correlation of these data w...

  5. GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.

    Science.gov (United States)

    Zhao, Yue; Sun, Yang; Ding, Youxiang; Wang, Xiaoping; Zhou, Yuxin; Li, Wenjun; Huang, Shaoliang; Li, Zhiyu; Kong, Lingyi; Guo, Qinglong; Lu, Na

    2015-09-22

    GL-V9, a new synthesized flavonoid derivative, has been reported to possess anti-cancer properties in our previous studies. Uncontrolled overproduction of reactive oxygen species (ROS) has been implicated in oxidative damage of inflammatory bowel disease (IBD). In this study, we aimed to investigate the protective effect of GL-V9 against dextran sulfate sodium (DSS)-induced colitis. GL-V9 attenuated DSS-induced body weight loss, colon length shortening and colonic pathological damage. GL-V9 also inhibited inflammatory cells infiltration and decreased myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities. Moreover, GL-V9 inhibited ROS and malondialdehyde (MDA) generation, but enhanced superoxide dismutase (SOD), glutathione (GSH) and total antioxidant capacity. GL-V9 reduced pro-inflammatory cytokines production in serum and colon as well. Mechanically, GL-V9 could increase Trx-1 via activation of AMPK/FOXO3a to suppress DSS-induced colonic oxidative stress. Furthermore, GL-V9 decreased pro-inflammatory cytokines and ROS production and increased the antioxidant defenses in the mouse macrophage cells RAW264.7 by promoting Trx-1 expression. In conclusion, our study demonstrated that GL-V9 attenuated DSS-induced colitis against oxidative stress by up-regulating Trx-1 via activation of AMPK/FOXO3a pathway, suggesting that GL-V9 might be a potential effective drug for colitis.

  6. 葡聚糖硫酸钠(DSS)诱导的小鼠肠炎模型中CD19+CD5+CD1dhiB细胞的表达及抑炎作用%The role of CD19+CD5+CD1dhi B cells in dextran sulfact sodium (DSS)induced inflammatory bowel disease C57BL/6 mouse model

    Institute of Scientific and Technical Information of China (English)

    汪路曼; 钱静; 刘小明; 常丽君; 储以微

    2013-01-01

    目的 探讨CD19+ CD5+ CD1dhiB细胞在葡聚糖硫酸钠(dextran sulfact sodium,DSS)诱导的C57BL/6小鼠肠炎模型中的表达及抑炎作用.方法 建立DSS诱导的小鼠肠炎模型(n=200),获取疾病不同阶段的脾淋巴细胞,流式细胞仪检测CD19+ CD5+ CD1 dhiB细胞的比例变化;体内转输该群细胞至疾病小鼠,观察小鼠肠炎临床评分以及肠道局部炎性因子分泌的变化.结果 在小鼠肠炎的急性期(第0~10天),CD19+ CD5+CD1 dhiB细胞比例明显增多,在肠炎消退期(第12天),其比例恢复到正常水平;转输疾病急性期(第8天)的CD19+ CD5+ CD1 dhiB细胞可有效控制疾病的进展,缓解病程;ELISA检测提示转输急性期的该群细胞可显著抑制肠道局部促炎细胞因子IFN-γ、TNF-α和IL-6的分泌.结论 DSS诱导的小鼠肠炎中CD19+ CD5+ CD1 dhiB细胞比例随病程发生改变,并可通过抑制肠道局部炎性细胞因子的分泌缓解病症.%Objective To investigate the change in cell number of CD19 + CD5+ Cdldhi B cells and its function in dextran sulfate sodium (DSS) induced inflammatory bowel disease (IBD) C57BL/6 mouse model. Methods The murine model of inflammatory bowel disease was set up by DSS treatment. Splenic CD19+ CD5+ Cdldhi B cells were harvested from mice during different disease stages,and were analyzed by flow cytometry. CD19+ CD5+ Cdldhi B cells were adoptively transferred to the DSS-treated mice, then clinical symptom was evaluated and the production of inflammatory cytokines in local intestine was detected. Results The proportion of CD19+ CD5+ Cdldhi B cells was increased in the acute phase (Day 0 - 10) of the disease and returned to baseline in the recovery phase (Day 12). Adoptive transfer of CD19+ CD5+ Cdldhi B cells from mice in acute phase (Day 8) remarkably inhibited the production of proinflammatory cytokines (IFN-γ, TNF-α and IL-6) in local intestine and resolved the inflammation. Conclusions The proportion of CD19+ CD5+ Cdldhi B

  7. Therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms%Allicin对DSS诱导的小鼠结肠炎的治疗作用及可能机制

    Institute of Scientific and Technical Information of China (English)

    陈晶; 李巧霞; 李玮; 李宏; 汤菲; 王缚鲲

    2016-01-01

    Objective:To analyze the therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms. Methods:A total of 24 male mice were randomly divided into Control group,DSS group(2. 5% DSS,7 days) and Allicin group [DSS treatment and Allicin,10 mg/(kg·d),7 d]. Disease activity index,inflammatory score,TUNEL and Western bolt were performed to analyze the effect of Allicin on colitis induced by DSS. Results: With DSS group, the Allicin group had lower disease activity score and inflammatory score(P<0. 05). Allicin group had a lower number of intestinal epithelial cell apoptosis than that of DSS group,the difference was statistically significant(P<0. 05). Western bolt analysis shown that Allicin treatment significantly depressed the expression of p-JAK2 and p-STAT3 in intestinal mucosa when compared with these of DSS group ( P<0. 05 ) . Conclusion:Conclusion Allicin has significantly therapeutic effect on mice colitis induced by DSS, the possible mechanisms including anti-inflammatory effects,protected of the intestinal epithelial cells and inhibition of the JAK2/STAT3 signaling pathways.%目的::明确Allicin对DSS诱导的小鼠结肠炎的治疗作用并进一步分析可能的机制。方法:将24只8周龄雄性BALB/c小鼠随机分为3组:Control组:阴性对照;DSS组:2.5%DSS诱导结肠炎;Allicin组:2.5%DSS诱导结肠炎+Allicin治疗[10 mg/(kg·d),共7 d]。结果:与DSS组比较,Allicin组疾病活动度评分及肠道炎症评分显著降低(P<0.05)。 Allicin治疗组小鼠肠上皮细胞凋亡数目显著低于DSS组。 Allicin治疗组小鼠肠黏膜炎症因子( IL-6、IL-1β及TNF-α)水平显著低于DSS组,差异均具有统计学意义( P<0.05)。与DSS组比较, Allicin治疗显著抑制了肠黏膜p-JAK2及p-STAT3的表达( P<0.05)。结论:Allicin对DSS小鼠肠炎具有治疗作用,可能的机制包括抗炎,保护肠上皮细胞及抑制JAK2/STAT3信号通路等。

  8. Comparison of 37 months global net radiation flux derived from PICARD-BOS over the same period observations of CERES and ARGO

    Science.gov (United States)

    Zhu, Ping; Wild, Martin

    2016-04-01

    The absolute level of the global net radiation flux (NRF) is fixed at the level of [0.5-1.0] Wm-2 based on the ocean heat content measurements [1]. The space derived global NRF is at the same order of magnitude than the ocean [2]. Considering the atmosphere has a negligible effects on the global NRF determination, the surface global NRF is consistent with the values determined from space [3]. Instead of studying the absolute level of the global NRF, we focus on the interannual variation of global net radiation flux, which were derived from the PICARD-BOS experiment and its comparison with values over the same period but obtained from the NASA-CERES system and inferred from the ocean heat content survey by ARGO network. [1] Allan, Richard P., Chunlei Liu, Norman G. Loeb, Matthew D. Palmer, Malcolm Roberts, Doug Smith, and Pier-Luigi Vidale (2014), Changes in global net radiative imbalance 1985-2012, Geophysical Research Letters, 41 (no.15), 5588-5597. [2] Loeb, Norman G., John M. Lyman, Gregory C. Johnson, Richard P. Allan, David R. Doelling, Takmeng Wong, Brian J. Soden, and Graeme L. Stephens (2012), Observed changes in top-of-the-atmosphere radiation and upper-ocean heating consistent within uncertainty, Nature Geoscience, 5 (no.2), 110-113. [3] Wild, Martin, Doris Folini, Maria Z. Hakuba, Christoph Schar, Sonia I. Seneviratne, Seiji Kato, David Rutan, Christof Ammann, Eric F. Wood, and Gert Konig-Langlo (2015), the energy balance over land and oceans: an assessment based on direct observations and CMIP5 climate models, Climate Dynamics, 44 (no.11-12), 3393-3429.

  9. R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.

    Science.gov (United States)

    Kang, Eugene; Yousefi, Mitra; Gruenheid, Samantha

    2016-01-01

    The R-spondin family of proteins has recently been described as secreted enhancers of β-catenin activation through the canonical Wnt signaling pathway. We previously reported that Rspo2 is a major determinant of susceptibility to Citrobacter rodentium-mediated colitis in mice and recent genome-wide association studies have revealed RSPO3 as a candidate Crohn's disease-specific inflammatory bowel disease susceptibility gene in humans. However, there is little information on the endogenous expression and cellular source of R-spondins in the colon at steady state and during intestinal inflammation. RNA sequencing and qRT-PCR were used to assess the expression of R-spondins at steady state and in two mouse models of colonic inflammation. The cellular source of R-spondins was assessed in specific colonic cell populations isolated by cell sorting. Data mining from publicly available datasets was used to assess the expression of R-spondins in the human colon. At steady state, colonic expression of R-spondins was found to be exclusive to non-epithelial CD45- lamina propria cells, and Rspo3/RSPO3 was the most highly expressed R-spondin in both mouse and human colon. R-spondin expression was found to be highly dynamic and differentially regulated during C. rodentium infection and dextran sodium sulfate (DSS) colitis, with notably high levels of Rspo3 expression during DSS colitis, and high levels of Rspo2 expression during C. rodentium infection, specifically in susceptible mice. Our data are consistent with the hypothesis that in the colon, R-spondins are expressed by subepithelial stromal cells, and that Rspo3/RSPO3 is the family member most implicated in colonic homeostasis. The differential regulation of the R-spondins in different models of intestinal inflammation indicate they respond to specific pathogenic and inflammatory signals that differ in the two models and provides further evidence that this family of proteins plays a key role in linking intestinal

  10. Bifidobacterium infantis strains with and without a combination of Oligofructose and Inulin (OFI attenuate inflammation in DSS-induced colitis in rats

    Directory of Open Access Journals (Sweden)

    Ahrne Siv

    2006-10-01

    Full Text Available Abstract Background Pathogenesis of inflammatory bowel disease is thought to be through different factors and there is a relationship between the gut flora and the risk of its development. Probiotics can manipulate the microflora in chronic inflammation and may be effective in treating inflammation. Bifidobacterium are saccharolytic and their growth in the gut can be promoted by non-absorbable carbohydrates and its increase in the colon appears to be of benefit. Methods Oligofructose and inulin (OFI alone and the two B. infantis DSM 15158 and DSM 15159 with and without OFI, were fed to Sprague-Dawley rats for 7 days prior to colitis induction and administrations continued for another 7 days with the DSS. Colitis severity assessed using a Disease Activity Index. Samples were collected 7 days after colitis induction, for intestinal bacterial flora, bacterial translocation, short chain fatty acids (SCFAs, myeloperoxidase (MPO, cytokines (IL-1β, TNF-α, IL-10 and TGF-β and malondialdehyde (MDA. Results OFI alone or the B. infantis strains with and without OFI improved significantly the DAI and decreased colonic MPO activity. Colonic tissue IL-1β decreased significantly in all treated groups except B. infantis DSM 15158. MDA decreased significantly in B. infantis DSM 15159 with and without OFI compared to colitis control. Succinic acid increased significantly in OFI group with and without DSM 15159 compared to all groups. Sum values of propionic, succinic acid and butyric acid increased significantly in all groups compare to the colitis control. Bacterial translocation to mesenteric lymph nodes decreased significantly in all groups compared to colitis control. Translocation to the liver decreased significantly in all groups compare to the colitis control and OFI + B. infantis DSM 15158 groups. Conclusion Administrations of OFI and Bifidobacterium improve DSS-induced acute colitis and have an anti-inflammatory effect. Major differences in effect

  11. 基于数据仓库的篮球教练辅助决策支持系统%Basketball Coach's Assistant DSS Based on Data Warehouse

    Institute of Scientific and Technical Information of China (English)

    方心飞; 叶枫; 周钧

    2011-01-01

    Now many basketball coaches only rely on their experience and specialty Skill when they do the decision.So in this case the coach's decision may be wrong and the team may lose the game. Even the coach may be fired.Concerning this problem, we can design this DSS (Decision Support System) to solve it. Here we use Data Warehouse and Data Mining skill to realize the DSS. And we use the assist data of Rockets players to experimental analysis. From the experimental results that frequent itemsets, we found the results were helpful for coaches on how to provide effective help. So we believe to some extent that the system can certainly provide some help and reference for the basketball coach.%现在的篮球教练做决策时候还仅仅依靠原先的经验和专业技能,这样的决策有时候往往会产生不好的效果导致球队输球,教练自己下岗.就这个问题笔者认为可以采用设计一个篮球教练辅助决策支持系统的方法给予一定程度的解决,具体在实现该系统时运用数据仓库和数据挖掘技术的方法,然后还以NBA球队火箭队球员在助攻维度的数据进行实验分析.从得出的实验结果即频繁项集发现,结果可以为教练如何排兵布阵提供有效的帮助,所以笔者相信该系统肯定可以在一定程度上为篮球教练决策时候提供一些帮助和参考.

  12. Study on welded structure fatigue of DSS used in shipbuilding%船用双相不锈钢焊接结构疲劳性能研究

    Institute of Scientific and Technical Information of China (English)

    王智祥; 王正伦; 张鑫

    2012-01-01

    文章对船用双相不锈钢焊接结构的焊缝、影响区和母材在不同应力比下分别进行了疲劳裂纹扩展实验,同时利用有限元分析软件进行了数值模拟,得到了裂纹扩展速率da/dN与应力强度因子(△ )K的关系曲线.研究结果表明:船用双相不锈钢焊接结构中焊缝裂纹扩展速率最低,抗疲劳裂纹扩展能力最高;母材疲劳裂纹扩展速率最高,抗疲劳裂纹扩展能力最差;焊缝对应力变化的灵敏度最高,热影响区次之,母材最弱;通过实验与模拟对比分析,表明数值模拟对船用双相不锈钢疲劳裂纹扩展速率定量分析是正确的且方法可行.%The fatigue crack growth grate in weld metal, heat-affected zone and base metal of Duplex Stain-less Steel (DSS) used in shipbuilding was tested at different stress ratios. FEM analysis software was used to simulate the steel under different stress ratio at the same time, and the AaldN-AK curves of this steel were obtained. The research results show that the fatigue crack growth rate of weld metal is the slowest and the ability to resist fatigue crack growth is the highest in the three parts, the lowest is base metal. Secondly, the sensitivity caused by the stress change of weld metal is the highest, and the lowest is base metal. The com-parison between finite element simulation and experiment shows that the simulation of fatigue crack growth rate of DSS used in shipbuilding is completely correct and feasible.

  13. A study of biodiversity using DSS method and seed storage protein comparison of populations in two species of Achillea L. in the west of Iran

    Directory of Open Access Journals (Sweden)

    Hajar Salehi

    2013-11-01

    Full Text Available Intarspecific and interspecific variations are the main reserves of biodiversity and both are important sources of speciation. On this basis, identifing and recognizing the intra and interspecific variations is important in order to recognition of biodiversity. This research was done to study biodiversity and electrophoresis comparison of seed storage proteins in the populations of the two species of the genus Achillea in Hamadan and Kurdistan provinces using of the method of determination of special station (DSS. For this purpose, 12 and 9 special stations were selected for the species A. tenuifolia and A. biebresteinii using the data published in the related flora. Seed storage proteins were extracted and then studied using electrophoresis techniques (SDS-PAGE. In survey of all special stations, 120 plant species were distinguished as associated species. The results of the floristic data for the both species determined six distinctive groups that indicated the existence of intraspecific diversity in this species. The result of analysis of ecological data and seed storage proteins for the two species was in accordance with the floristic data and showed six distinctive groups. The existence of the bands of no. 4, 5, 8, 12 and 13 in the special stations of A. tenuifolia and the bands of 14, 15 and 16 in the special stations of A. biebresteinii o separated the populations of the species in two quite different and distinctive groups.

  14. 基于黑板的多Agent体育训练管理DSS系统设计%Design of multi-Agent sports training management DSS based on blackboard

    Institute of Scientific and Technical Information of China (English)

    张维

    2014-01-01

    The shortcomings that sports training management is not science,the training purpose is not clear,and the auxi-liary decision means lags behind,still exist in China at present. A scheme to realize the multi-Agent intelligent DSS based on blackboard for sports training management was designed,in which Agent and DSS technology are applied. The system was imple-mented,so as to effectively improve the accuracy and intelligence of DSS.%目前我国的体育训练管理中仍然存在着不科学、训练目的性不强、辅助决策手段落后等缺点。将Agent和DSS技术运用到系统当中,设计出一个基于黑板的多Agent智能体育训练管理决策支持系统方案,并进行具体的实施,从而有效地提高了决策系统的准确性和智能性。

  15. 台湾东北部黑潮表层水入侵东海陆架的季节变化规律%The seasonal variability of the Kuroshio surface water intru-sion onto the East China Sea continental shelf derived from Argos drifter data

    Institute of Scientific and Technical Information of China (English)

    赵瑞祥; 刘志亮

    2015-01-01

    seasonal feature: the Kuroshio surface water intrusion onto the East China Sea continental shelf is strong in fall and winter, and weak in spring and summer. This paper utilizes the latest Argos drifter data to reveal the seasonal variability of Kuroshio surface water intrusion onto the East China Sea continental shelf.

  16. Gaussian Affine Feature Detector

    OpenAIRE

    Xu, Xiaopeng; Zhang, Xiaochun

    2011-01-01

    A new method is proposed to get image features' geometric information. Using Gaussian as an input signal, a theoretical optimal solution to calculate feature's affine shape is proposed. Based on analytic result of a feature model, the method is different from conventional iterative approaches. From the model, feature's parameters such as position, orientation, background luminance, contrast, area and aspect ratio can be extracted. Tested with synthesized and benchmark data, the method achieve...

  17. Improvement of radiological consequence estimation methodologies for NPP accidents in the ARGOS and RODOS decision support systems through consideration of contaminant physico-chemical forms

    International Nuclear Information System (INIS)

    The European standard computerized decision support systems RODOS and ARGOS, which are integrated in the operational nuclear emergency preparedness in practically all European countries, as well as in a range of non-European countries, are highly valuable tools for radiological consequence estimation, e.g., in connection with planning and exercising as well as in justification and optimization of intervention strategies. Differences between the Chernobyl and Fukushima accident atmospheric release source terms have demonstrated that differences in release conditions and processes may lead to very different degrees of volatilization of some radionuclides. Also the physico-chemical properties of radionuclides released can depend strongly on the release process. An example from the Chernobyl accident of the significance of this is that strontium particles released in the fire were oxidized and thus generally physico-chemically different from those released during the preceding explosion. This is reflected in the very different environmental mobility of the two groups of particles. The initial elemental matrix characteristics of the contaminants, as well as environmental parameters like pH, determine for instance the particle dissolution time functions, and thus the environmental mobility and potential for uptake in living organisms. As ICRP recommends optimization of intervention according to residual dose, it is crucial to estimate long term dose contributions adequately. In the EURATOM FP7 project PREPARE, an effort is made to integrate physico-chemical forms of contaminants in scenario-specific source term determination, thereby enabling consideration of influences on atmospheric dispersion/deposition, post-deposition migration, and effectiveness of countermeasure implementation. The first step in this context was to investigate, based on available experience, the important physico-chemical properties of radio-contaminants that might potentially be released to the

  18. Parallel Feature Extraction System

    Institute of Scientific and Technical Information of China (English)

    MAHuimin; WANGYan

    2003-01-01

    Very high speed image processing is needed in some application specially for weapon. In this paper, a high speed image feature extraction system with parallel structure was implemented by Complex programmable logic device (CPLD), and it can realize image feature extraction in several microseconds almost with no delay. This system design is presented by an application instance of flying plane, whose infrared image includes two kinds of feature: geometric shape feature in the binary image and temperature-feature in the gray image. Accordingly the feature extraction is taken on the two kind features. Edge and area are two most important features of the image. Angle often exists in the connection of the different parts of the target's image, which indicates that one area ends and the other area begins. The three key features can form the whole presentation of an image. So this parallel feature extraction system includes three processing modules: edge extraction, angle extraction and area extraction. The parallel structure is realized by a group of processors, every detector is followed by one route of processor, every route has the same circuit form, and works together at the same time controlled by a set of clock to realize feature extraction. The extraction system has simple structure, small volume, high speed, and better stability against noise. It can be used in the war field recognition system.

  19. Lymphotoxin-beta receptor activation on macrophages ameliorates acute DSS-induced intestinal inflammation in a TRIM30α-dependent manner.

    Science.gov (United States)

    Wimmer, Nadin; Huber, Barbara; Wege, Anja K; Barabas, Nicola; Röhrl, Johann; Pfeffer, Klaus; Hehlgans, Thomas

    2012-06-01

    Our previous studies indicated that LTβR activation mainly by T cell derived LTα₁β₂ is crucial for the control and down-regulation of intestinal inflammation. In order to dissect the cellular and molecular role of LTβR activation in the experimental model of DSS-induced intestinal inflammation, we have generated cell type-specific LTβR-deficient mice with specific ablation of LTβR expression on macrophages/neutrophils (LTβR((flox/flox))×LysM-Cre). These mice develop an exacerbated intestinal inflammation in our experimental model indicating that LTβR expression on macrophages/neutrophils is responsible for the control and down-regulation of the inflammatory reaction. These results were verified by adoptive transfer experiments of BMDM from wild-type and LTβR-deficient mice. Furthermore, transfer of activated CD4+ T cells derived from wild-type mice, but not from LTβR ligand-deficient mice attenuated the signs of intestinal inflammation. Finally, we demonstrate that LTβR activation on BMDM results in induction of TRIM30α, a negative regulator of NFκB activation. Concordantly, ablation of LTβR signaling results in the inability to induce TRIM30α expression concomitant with an increased expression of pro-inflammatory cytokines in our experimental model. Taken together, our data demonstrate that LTβR activation on macrophages by CD4+ T cell derived LTαβ controls the pro-inflammatory response by activation of a TRIM30α-dependent signaling pathway, crucial for the down-regulation of the inflammatory response in this experimental model. PMID:22437076

  20. Feature Extraction of Mammograms

    Directory of Open Access Journals (Sweden)

    Monika Sharma

    2012-09-01

    Full Text Available Breast cancer is the second leading cause of cancer deaths in women today. Early detection of the cancer can reduce mortality rate. Studies have shown that radiologists can miss the detection of a significant proportion of abnormalities in addition to having high rates of false positives. Pattern recognition in image processing requires the extraction of features from regions of the image and the processing of these features with a pattern recognition algorithm. We consider the feature extraction part of this processing; with a focus on the problem of micro calcification detection in digital mammography. For every pattern classification problem, the most important stage is feature extraction. The accuracy of the classification depends on the feature extraction stage. We have extracted textural, statistical and structural features which show promising results than most of the existing technology.

  1. Feature Extraction of Mammograms

    Directory of Open Access Journals (Sweden)

    Monika Sharma

    2012-09-01

    Full Text Available Breast cancer is the second leading cause of cancer deathsin women today. Early detection of the cancer can reducemortality rate. Studies have shown that radiologists canmiss the detection of a significant proportion ofabnormalities in addition to having high rates of falsepositives. Pattern recognition in image processing requiresthe extraction of features from regions of the image andthe processing of these features with a pattern recognitionalgorithm. We consider the feature extraction part of thisprocessing; with a focus on the problem of microcalcification detection in digital mammography. For everypattern classification problem, the most important stage isfeature extraction. The accuracy of the classificationdepends on the feature extraction stage. We have extractedtextural, statistical and structural features which showpromising results than most of the existing technology.

  2. Washingtoni varjatumad vestlused / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2007-01-01

    President Toomas Hendrik Ilvese kohtumistel USA presidendi George W. Bushi, kaitseminister Robert M. Gates'i ja juhtivate kongresmenidega olid kõne all viisavabadus, Eestisse NATO küberkeskuse rajamine ning ka suhted Venemaaga. Vabariigi President töövisiidil Ameerika Ühendriikides 25.-26.06.2007

  3. Endine patsiga poiss / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2007-01-01

    E-hääletuse süsteemi looja Tarvi Martens sai organisatsioonilt Junior Chamber International (Rahvusvaheline Noortekoda) auhinna. T. Martens ei luba, et lähiajal käivituksid Eestis uued, maailma vapustavad e-lahendused, vaid leiab, et inimesed võiksid rohkem kasutada juba olemasolevaid lahendusi. Eesmärk on, et Eesti oleks 2009. aastaks kõige turvalisema internetiga riik

  4. DSS--A Promising Future.

    Science.gov (United States)

    Penrod, James I.; Wasileski, John S.

    1985-01-01

    A description of how the decision support systems at Pepperdine University are helping its office of institutional research and planning provide the support necessary to keep the university's administration well-informed in their decision-making role is presented. (MLW)

  5. IL-33 alleviates DSS-induced chronic colitis in C57BL/6 mice colon lamina propria by suppressing Th17 cell response as well as Th1 cell response.

    Science.gov (United States)

    Zhu, Junfeng; Wang, Yuanyuan; Yang, Fangli; Sang, Lixuan; Zhai, Jingbo; Li, Shengjun; Li, Yan; Wang, Danan; Lu, Changlong; Sun, Xun

    2015-12-01

    Interleukin (IL)-33, a member of the IL-1 cytokine family, is associated with autoimmune diseases including inflammatory bowel diseases (IBD). A few studies on animal models have shown that IL-33 can suppress Th1 cell response and improve Th2 cell response in mesenteric lymph nodes (MLN) and sera. However, there is little data published about the effect of IL-33 on Th17 cell in and Th1/Th2 cell in colon lamina propria. The aim of this study was to investigate the effect of IL-33 on Th17 cell in colon lamina propria of mice with dextran sulfate sodium (DSS) induced chronic colitis. We studied the influence of IL-33 on colonic tissue injury and clinical symptoms of colitis. The T cell subsets were measured by flow cytometry and the production of cytokines secreted by lamina propria lymphocytes (LPL) was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and quantitative real-time PCR. We have found that rIL-33 treatment led to a significant alleviation of DSS induced chronic colitis as evidenced by 1) alleviation of weight loss, DAI, macroscopic changes and histological score; 2) down-regulating the rates and absolute cell numbers of Th17 and Th1 cell in LPL; 3) inducing secretion of lower levels of IFN-γ and IL-17A. It is therefore concluded that IL-33 may play a therapeutic role in DSS-induced chronic colitis in mice by suppressing Th17 response and switching Th1 to Th2 response.

  6. Quasi-static time-series simulation using OpenDSS in IEEE distribution feeder model with high PV penetration and its impact on solar forecasting

    Science.gov (United States)

    Mohammed, Touseef Ahmed Faisal

    Since 2000, renewable electricity installations in the United States (excluding hydropower) have more than tripled. Renewable electricity has grown at a compounded annual average of nearly 14% per year from 2000-2010. Wind, Concentrated Solar Power (CSP) and solar Photo Voltaic (PV) are the fastest growing renewable energy sectors. In 2010 in the U.S., solar PV grew over 71% and CSP grew by 18% from the previous year. Globally renewable electricity installations have more than quadrupled from 2000-2010. Solar PV generation grew by a factor of more than 28 between 2000 and 2010. The amount of CSP and solar PV installations are increasing on the distribution grid. These PV installations transmit electrical current from the load centers to the generating stations. But the transmission and distribution grid have been designed for uni-directional flow of electrical energy from generating stations to load centers. This causes imbalances in voltage and switchgear of the electrical circuitry. With the continuous rise in PV installations, analysis of voltage profile and penetration levels remain an active area of research. Standard distributed photovoltaic (PV) generators represented in simulation studies do not reflect the exact location and variability properties such as distance between interconnection points to substations, voltage regulators, solar irradiance and other environmental factors. Quasi-Static simulations assist in peak load planning hour and day ahead as it gives a time sequence analysis to help in generation allocation. Simulation models can be daily, hourly or yearly depending on duty cycle and dynamics of the system. High penetration of PV into the power grid changes the voltage profile and power flow dynamically in the distribution circuits due to the inherent variability of PV. There are a number of modeling and simulations tools available for the study of such high penetration PV scenarios. This thesis will specifically utilize OpenDSS, a open source

  7. Feature selection in bioinformatics

    Science.gov (United States)

    Wang, Lipo

    2012-06-01

    In bioinformatics, there are often a large number of input features. For example, there are millions of single nucleotide polymorphisms (SNPs) that are genetic variations which determine the dierence between any two unrelated individuals. In microarrays, thousands of genes can be proled in each test. It is important to nd out which input features (e.g., SNPs or genes) are useful in classication of a certain group of people or diagnosis of a given disease. In this paper, we investigate some powerful feature selection techniques and apply them to problems in bioinformatics. We are able to identify a very small number of input features sucient for tasks at hand and we demonstrate this with some real-world data.

  8. Fingerprint Feature Extraction Algorithm

    Directory of Open Access Journals (Sweden)

    Mehala. G

    2014-03-01

    Full Text Available The goal of this paper is to design an efficient Fingerprint Feature Extraction (FFE algorithm to extract the fingerprint features for Automatic Fingerprint Identification Systems (AFIS. FFE algorithm, consists of two major subdivisions, Fingerprint image preprocessing, Fingerprint image postprocessing. A few of the challenges presented in an earlier are, consequently addressed, in this paper. The proposed algorithm is able to enhance the fingerprint image and also extracting true minutiae.

  9. Feature Model Differences

    OpenAIRE

    Acher, Mathieu; Heymans, Patrick; Collet, Philippe; Quinton, Clément; Lahire, Philippe; Merle, Philippe

    2012-01-01

    International audience Feature models are a widespread means to represent commonality and variability in software product lines. As is the case for other kinds of models, computing and managing feature model differences is useful in various real-world situations. In this paper, we propose a set of novel differencing techniques that combine syntactic and semantic mechanisms, and automatically produce meaningful differences. Practitioners can exploit our results in various ways: to understan...

  10. Fingerprint Feature Extraction Algorithm

    OpenAIRE

    Mehala. G

    2014-01-01

    The goal of this paper is to design an efficient Fingerprint Feature Extraction (FFE) algorithm to extract the fingerprint features for Automatic Fingerprint Identification Systems (AFIS). FFE algorithm, consists of two major subdivisions, Fingerprint image preprocessing, Fingerprint image postprocessing. A few of the challenges presented in an earlier are, consequently addressed, in this paper. The proposed algorithm is able to enhance the fingerprint image and also extractin...

  11. Feature Technology in Product Modeling

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xu; NING Ruxin

    2006-01-01

    A unified feature definition is proposed. Feature is form-concentrated, and can be used to model product functionalities, assembly relations, and part geometries. The feature model is given and a feature classification is introduced including functional, assembly, structural, and manufacturing features. A prototype modeling system is developed in Pro/ENGINEER that can define the assembly and user-defined form features.

  12. Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation.

    Science.gov (United States)

    Shin, Ji-Sun; Yun, Kyung-Jin; Chung, Kyung-Sook; Seo, Kyeong-Hwa; Park, Hee-Juhn; Cho, Young-Wuk; Baek, Nam-In; Jang, Daesik; Lee, Kyung-Tae

    2013-03-01

    We previously demonstrated that monotropein isolated from the roots of Morinda officinalis (Rubiaceae) has anti-inflammatory effects in vivo. In the present study, we investigated the molecular mechanisms underlying the anti-inflammatory effects of monotropein in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein was found to inhibit the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) mRNA in LPS-induced RAW 264.7 macrophages. Treatment with monotropein decreased the DNA binding activity of nuclear factor-κB (NF-κB). Consistent with these findings, monotropein also suppressed phosphorylation and degradation of inhibitory κB-α (IκB-α), and consequently the translocations of NF-κB. In the DSS-induced colitis model, monotropein reduced disease activity index (DAI), myeloperoxidase (MPO) activity, and inflammation-related protein expressions by suppressing NF-κB activation in colon mucosa. Taken together, these findings suggest that the anti-inflammatory effects of monotropein are mainly related to the inhibition of the expressions of inflammatory mediators via NF-κB inactivation, and support its possible therapeutic role in colitis. PMID:23261679

  13. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas;

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...

  14. Features and Agreement

    CERN Document Server

    Bayer, S; Bayer, Sam; Johnson, Mark

    1995-01-01

    This paper compares the consistency-based account of agreement phenomena in `unification-based' grammars with an implication-based account based on a simple feature extension to Lambek Categorial Grammar (LCG). We show that the LCG treatment accounts for constructions that have been recognized as problematic for `unification-based' treatments.

  15. Live facial feature extraction

    Institute of Scientific and Technical Information of China (English)

    ZHAO JieYu

    2008-01-01

    Precise facial feature extraction is essential to the high-level face recognition and expression analysis. This paper presents a novel method for the real-time geomet-ric facial feature extraction from live video. In this paper, the input image is viewed as a weighted graph. The segmentation of the pixels corresponding to the edges of facial components of the mouth, eyes, brows, and nose is implemented by means of random walks on the weighted graph. The graph has an 8-connected lattice structure and the weight value associated with each edge reflects the likelihood that a random walker will cross that edge. The random walks simulate an anisot-ropic diffusion process that filters out the noise while preserving the facial expres-sion pixels. The seeds for the segmentation are obtained from a color and motion detector. The segmented facial pixels are represented with linked lists in the origi-nal geometric form and grouped into different parts corresponding to facial com-ponents. For the convenience of implementing high-level vision, the geometric description of facial component pixels is further decomposed into shape and reg-istration information. Shape is defined as the geometric information that is invari-ant under the registration transformation, such as translation, rotation, and iso-tropic scale. Statistical shape analysis is carried out to capture global facial fea-tures where the Procrustes shape distance measure is adopted. A Bayesian ap-proach is used to incorporate high-level prior knowledge of face structure. Ex-perimental results show that the proposed method is capable of real-time extraction of precise geometric facial features from live video. The feature extraction is robust against the illumination changes, scale variation, head rotations, and hand inter-ference.

  16. Features of Women's language

    Institute of Scientific and Technical Information of China (English)

    何延凌

    2008-01-01

    Language is a means of verbal communication.People use language to communicate with each other.In the society,no two speakers are exactly alike in the way of speaking.Some differences are due to age,gender,statue and personality. Above all,gender is one of the obvious reasons.The writer of this paper tries to describe the features of women's language from these perspectives: pronunciation,intonation,diction,subjects,grammar and discourse.From the discussion of the features of women's language,more attention should be paid to language use in social context.What's more,the linguistic phenomena in a speaking community can be understood more thoroughly.

  17. Extending Scalasca's analysis features

    OpenAIRE

    Lorenz, Daniel; Böhme, David; Mohr, Bernd; Strube, Alexandre; Szebenyi, Zoltan

    2013-01-01

    Scalasca is a performance analysis tool, which parses the trace of an application run for certain patterns that indicate performance inefficiencies. In this paper, we present recently developed new features in Scalasaca. In particular, we describe two newly implemented analysis methods: the root cause analysis which tries to identify the cause of a delay and the critical path analysis, which analyses the path of execution that determines the application runtime. Furthermore, we present time-s...

  18. Functions & Features of Idioms

    Institute of Scientific and Technical Information of China (English)

    周来纳

    2015-01-01

    Idioms, or conventionalized multiword expressions, often but not always non-literal, are hardly marginal in English, though they have been relatively neglected in lexical studies of the language. This neglect is especially evident in respect of the functions of idioms. The aim of this article, accordingly, is to account for the functions of idioms by analyzing what they do with the features of idioms.

  19. CBFS: high performance feature selection algorithm based on feature clearness.

    Directory of Open Access Journals (Sweden)

    Minseok Seo

    Full Text Available BACKGROUND: The goal of feature selection is to select useful features and simultaneously exclude garbage features from a given dataset for classification purposes. This is expected to bring reduction of processing time and improvement of classification accuracy. METHODOLOGY: In this study, we devised a new feature selection algorithm (CBFS based on clearness of features. Feature clearness expresses separability among classes in a feature. Highly clear features contribute towards obtaining high classification accuracy. CScore is a measure to score clearness of each feature and is based on clustered samples to centroid of classes in a feature. We also suggest combining CBFS and other algorithms to improve classification accuracy. CONCLUSIONS/SIGNIFICANCE: From the experiment we confirm that CBFS is more excellent than up-to-date feature selection algorithms including FeaLect. CBFS can be applied to microarray gene selection, text categorization, and image classification.

  20. 肠黏膜细胞TLR9活化对DSS诱导小鼠溃疡性结肠炎模型的影响%Effects of Activated TLR9 in Intestinal Epithelium on Ulcerative Colitis Induced by DSS in Mice

    Institute of Scientific and Technical Information of China (English)

    孙鹏; 周晓晶; 刘伯岩; 杨文颖

    2012-01-01

    Objective To study the effect of activated TLR9 in intestinal epithelium on ulcerative colitis induced by DSS in mice.Method Mice were randomly divided into six groups:PBS group,CpG ODN group,control ODN group,DSS+PBS group,DSS+CpG ODN group and DSS+control ODN group.The mice in PBS group,CpG ODN group and control ODN group were fed normally and were injected intraperitoneally with PBS,CpG ODN,and control ODN,respectively.The mice in DSS+PBS group,DSS+CpG ODN group and DSS+control ODN group were fed with DSS in water for drinking and were injected intraperitoneally with PBS,CpG ODN,and control ODN,respectively.Disease active index(DAI)was recorded every day.After ten days the mice were killed and their colons were taken out to undergo histological examination.Results The loss of weight in DSS+CpG ODN group was more than those in other groups(P0.05).Moreover,the DAI score and histological score in the group of DSS+CpG ODN were significantly higher than those in other groups(P0.05).Conclusion The CpG ODN could aggravate the ulcerative colitis induced by DSS in mice.%目的研究肠黏膜细胞内TLR9的活化对DSS诱导小鼠溃疡性结肠炎的影响.方法将小鼠随机分为6组,分别为PBS组、CpG ODN组、对照 ODN组、DSS+PBS组、DSS+CpG ODN组和DSS+对照 ODN组.其中PBS组、CpG ODN组、对照 ODN组的小鼠正常喂养,在当天给这3组小鼠通过腹腔分别注射PBS、CpG ODN和CpG ODN的对照 ODN;而给予DSS+PBS组、DSS+CpG ODN组和DSS对照 ODN组小鼠喂饲含有DSS的水,同样于当天给这3组小鼠通过腹腔分别注射PBS、CpG ODN和CpG ODN的对照 ODN.每天观察各组小鼠的状态、大便性状及大便隐血情况,作DAI评分;记录小鼠体质量变化.于第10天处死小鼠,分离结肠组织,进行组织学评分.结果经观察及检测发现:DSS+CpG ODN组小鼠的体质量下降明显,且状态不佳,DAI评分及组织学评分最高.结论 CpG ODN可加重DSS诱导的小鼠溃疡性结肠炎