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Sample records for argos dss feature

  1. Dose modelling for 'dirty bomb' scenarios - an ARGOS DSS feature under development

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Mikkelsen, Torben; Astrup, Poul;

    The world of today is not only facing the risk of accidents (e.g., in nuclear facilities, as considered in the EURANOS project). Also other types of emergencies, notably involving radiological terrorism, pose a threat. Acts of terror would be most likely to take place in a city, where the greates...

  2. Hydrodynamic features of the South Aegean Sea as derived from Argo T/ S and dissolved oxygen profiles in the area

    Science.gov (United States)

    Kassis, Dimitris; Krasakopoulou, Evangelia; Korres, Gerasimos; Petihakis, George; Triantafyllou, George S.

    2016-11-01

    In this work, the hydrodynamic picture of the South Aegean Sea is examined through an analysis of recent measurements in its sub-basins, the Myrtoan and Cretan Sea. Both sub-basins play an important role in the water circulation, exchange, and formation processes that affect the dynamics of the whole Eastern Mediterranean. For the first time, Bio-Argo floats were deployed in the area under the Greek Argo Research Infrastructure coordination. The acquired profiles cover an almost 2-year period (November 2013-July 2015) and are compared with previous Argo profiles and the re-processed time-series data recorded from the E1-M3A POSEIDON observatory operating in the area since 2007. The spatio-temporal distribution of the physical and chemical properties in each sub-basin is examined. Dense water formation events are revealed in the northern part (Myrtoan), while the wider area can be characterized as pre-conditioned. In the Cretan basin, a strong inter-annual variability of the salinity field at intermediate and deep layers is observed that is associated with water exchange from its open boundaries. Furthermore, comparison of the dissolved oxygen (DO) distribution with physical water properties within both the mixed layer, and at greater depths, indicated that relatively high but still under-saturated DO values are more likely to be associated with convection events. Finally, an updated picture of the physical properties and the DO distribution is presented based on the last 5 years of measurements and the recent introduction of Bio-Argo floats with DO sensors in the area.

  3. NKS NordDSS - report from workshop on the use of Decision Support Systems

    Energy Technology Data Exchange (ETDEWEB)

    Dyve, J.E. (Norwegian Radiation Protection Authority (Norway))

    2010-03-15

    Nuclear preparedness and response authorities in the Nordic countries are using decision support systems (DSS) as part of their operational capability. A DSS compile, display and analyse data that makes up the current and future radiological state of an emergency. ARGOS and RODOS are the two most common systems in use in the Nordic region. The aim of of the NordDSS workshop was to gather Nordic and international experts on DSS, and share knowledge and experience. The workshop brought together 22 experts for two days in Copenhagen. (author)

  4. DSS 13 microprocessor antenna controller

    Science.gov (United States)

    Gosline, R. M.

    1988-01-01

    A microprocessor-based antenna monitor and control system with multiple CPUs are described. The system was developed as part of the unattended station project for DSS 13 and was enhanced for use by the SETI project. The operational features, hardware, and software designs are described, and a discussion is provided of the major problems encountered.

  5. Animal Tracking ARGOS vs GPS

    Science.gov (United States)

    Robinson, P. W.; Costa, D.; Arnould, J.; Weise, M.; Kuhn, C.; Simmons, S. E.; Villegas, S.; Tremblay, Y.

    2006-12-01

    ARGOS satellite tracking technology has enabled a tremendous increase in our understanding of the movement patterns of a diverse array of marine vertebrates from Sharks to marine mammals. Our current understanding has moved from simple descriptions of large scale migratory patterns to much more sophisticated comparisons of animal movements and behavior relative to oceanic features. Further, animals are increasingly used to carry sensors that can acquire water column temperature and salinity profiles. However, a major limitation of this work is the spatial precision of ARGOS locations. ARGOS provides 7 location qualities that range from 3,2,1,0,A,B,Z and correspond to locations with a precision of 150m to tens of kilometers. Until recently, GPS technology could not be effectively used with marine mammals because they did not spend sufficient time at the surface to allow complete acquisition of satellite information. The recent development of Fastloc technology has allowed the development of GPS tags that can be deployed on marine mammals. Here we compare the location quality and frequency derived from standard ARGOS PTTs to Fastloc GPS locations acquired from 11 northern elephant seals, 5 California and 5 Galapagos sea lions and 1 Cape and 3 Australian fur seals. Our results indicate that GPS technology will greatly enhance our ability to understand the movement patterns of marine vertebrates and the in-situ oceanographic data they collect.

  6. Hydrodynamic features of the South Aegean Sea as derived from Argo T/S and dissolved oxygen profiles in the area

    Science.gov (United States)

    Kassis, Dimitris; Krasakopoulou, Evangelia; Korres, Gerasimos; Petihakis, George; Triantafyllou, George S.

    2016-09-01

    In this work, the hydrodynamic picture of the South Aegean Sea is examined through an analysis of recent measurements in its sub-basins, the Myrtoan and Cretan Sea. Both sub-basins play an important role in the water circulation, exchange, and formation processes that affect the dynamics of the whole Eastern Mediterranean. For the first time, Bio-Argo floats were deployed in the area under the Greek Argo Research Infrastructure coordination. The acquired profiles cover an almost 2-year period (November 2013-July 2015) and are compared with previous Argo profiles and the re-processed time-series data recorded from the E1-M3A POSEIDON observatory operating in the area since 2007. The spatio-temporal distribution of the physical and chemical properties in each sub-basin is examined. Dense water formation events are revealed in the northern part (Myrtoan), while the wider area can be characterized as pre-conditioned. In the Cretan basin, a strong inter-annual variability of the salinity field at intermediate and deep layers is observed that is associated with water exchange from its open boundaries. Furthermore, comparison of the dissolved oxygen (DO) distribution with physical water properties within both the mixed layer, and at greater depths, indicated that relatively high but still under-saturated DO values are more likely to be associated with convection events. Finally, an updated picture of the physical properties and the DO distribution is presented based on the last 5 years of measurements and the recent introduction of Bio-Argo floats with DO sensors in the area.

  7. The ARGO Project

    Science.gov (United States)

    Kozameh, C. N.

    El proyecto µARGO propone el desarrollo, construcción y operación del Observatorio Espacial de Rayos Gamma, que operará en una órbita terrestre. Este observatorio constará de un telescopio con capacidad de medir simultáneamente dirección de incidencia y polarización de rayos Gamma en dos rangos de energía: 50 KeV - 3 MeV y 10 MeV - 1 GeV. Para ello se usarán detectores de silicio de última generación y microelectrónica adaptada a la configuración. La masa total en órbita del observatorio estará en el orden de los 60 - 100 kg. dependiendo de la geometría adoptada lo que permitirá minimizar costos de desarrollo y construcción, sin perder por ello calidad en su misión científica. ? Desde el punto de vista energético μARGO cubrirá el rango cubierto por COMPTEL y EGRET del CGRO, duplicando como mínimo la resolución angular de ambos con una reducción de peso de dos órdenes de magnitud. En adición, μARGO podr´ medir la polarización incidente de los rayos energéticos. Si bien existen otros dos proyectos en marcha (GLAST y AGILE) para reemplazar EGRET que serán lanzados antes que μARGO, estos proyectos no están diseñados para medir polarización ni tampoco cubren el rango mas bajo de energía arriba mencionado.

  8. ARGO-YBJ Highlights

    CERN Document Server

    Di Sciascio, G

    2010-01-01

    The ARGO-YBJ experiment is a multipurpose detector exploiting the full-coverage approach at very high altitude. The apparatus is in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). In this paper we report the main results in Gamma-Ray Astronomy and Cosmic Ray Physics after about 3 years of operations.

  9. Katrin & Argo Vaikla / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2004-01-01

    Argo (sünd. 1966) ja Katrin (sünd. 1964) Vaikla eesti sisearhitektuurist, arhitektuurist, kodu kujundamisest, keskkonna mõjust inimesele jm. Argo ja Katrin Vaiklast, omistatud preemiad. 1992. a. asutasid disaini- ja sisearhitektuuribüroo AS Vaikla Disain. Olulisemad Vaikla Disaini projektide alusel teostatud sisekujundused. Ill.: värv. foto A. ja K. Vaiklast

  10. Customised DSS and decision conferences

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn; Leleur, Steen

    2009-01-01

    This paper presents and exemplifies a combination of techniques for deriving and modelling decision-maker and/or stakeholder preferences using a decision conference process. The applied techniques are used for the development of customised decision support systems (C-DSS) which can be used...... for appraisals of large transport infrastructure projects. The paper exemplifies how the process at a decision conference can be effectively supported by a DSS customised using appropriate techniques for the specific task in hand. In this respect a conventional cost-benefit analysis (CBA) is combined...

  11. How Incorporating Feedback Mechanisms in a DSS Affects DSS Evaluations

    NARCIS (Netherlands)

    U. Kayande (Ujwal); A. de Bruyn (Arnoud); G.L. Lilien (Gary); A. Rangaswamy (Arvind); G.H. van Bruggen (Gerrit)

    2008-01-01

    textabstractModel-based decision support systems (DSSs) improve performance in many contexts that are datarich, uncertain, and require repetitive decisions. But such DSSs are often not designed to help users understand and internalize the underlying factors driving DSS recommendations. Users then fe

  12. How Incorporating Feedback Mechanisms in a DSS Affects DSS Evaluations

    NARCIS (Netherlands)

    U. Kayande (Ujwal); A. de Bruyn (Arnoud); G.L. Lilien (Gary); A. Rangaswamy (Arvind); G.H. van Bruggen (Gerrit)

    2009-01-01

    textabstractModel-based decision support systems (DSSs) improve performance in many contexts that are datarich, uncertain, and require repetitive decisions. But such DSSs are often not designed to help users understand and internalize the underlying factors driving DSS recommendations. Users then fe

  13. Puitmaja klaster : intervjuu Argo Sauliga / Argo Saul ; intervjueerinud Kalle Komissarov

    Index Scriptorium Estoniae

    Saul, Argo

    2010-01-01

    Eesti Puitmajaliidu juhatuse esimehe ning Nordic Houses osaniku ja juhatuse esimehe Argo Sauliga arhitektide ja tüüpmaja tootjate võimalikust koostööst Eesti puitmaja klastris, millega Eesti Arhitektide Liit on liitunud. Nordic Houses on norra arhitektide projektide järgi tootnud ja tarninud üle 700 puhkemaja Norrasse

  14. Capstone Renaissance = Simulation + Interaction + DSS.

    Science.gov (United States)

    Jauch, Lawrence R.; And Others

    1989-01-01

    Reviews the development of integrated business policy and strategic management courses, or capstone courses, in business school curricula. A simulation game is described that incorporates the need for computer literacy, decision support systems (DSS), and interaction to effectively meet the needs for a capstone course. (14 references) (LRW)

  15. Reval Hotel Lietuva / Argo Vaikla

    Index Scriptorium Estoniae

    Vaikla, Argo, 1966-

    2004-01-01

    Vilniuse hotelli "Lietuva" renoveerimine. Arhitektuurne renoveerimisprojekt: Aare Saks, Nils Palm (SWECO FFNS Arkitekter AB, Rootsi), Rolandas Palekas (UAB Viltekta). Sisekujundus: Katrin ja Argo Vaikla, Liis Lindvere, Peeter Loo (Vaikla Disain AS). Ehitaja: Merko Statyba UAB. Projekt 2002, valmis 2003. I korruse plaan, välisvaade, 4 sisevaadet

  16. Moderating Argos location errors in animal tracking data

    Science.gov (United States)

    Douglas, David C.; Weinziert, Rolf; Davidson, Sarah C.; Kays, Roland; Wikelski, Martin; Bohrer, Gil

    2012-01-01

    1. The Argos System is used worldwide to satellite-track free-ranging animals, but location errors can range from tens of metres to hundreds of kilometres. Low-quality locations (Argos classes A, 0, B and Z) dominate animal tracking data. Standard-quality animal tracking locations (Argos classes 3, 2 and 1) have larger errors than those reported in Argos manuals.

  17. Using Business Games in Teaching DSS

    Science.gov (United States)

    Ben-Zvi, Tal

    2007-01-01

    In this study a business game is used as a vehicle for implementing decision support systems (DSS). Eighteen companies, consisting of ninety graduating M.B.A. students, participating in a business game were required to develop DSS and to report on the systems developed. Each of the eighteen companies developed a system of their own choosing,…

  18. ARGOS laser system mechanical design

    Science.gov (United States)

    Deysenroth, M.; Honsberg, M.; Gemperlein, H.; Ziegleder, J.; Raab, W.; Rabien, S.; Barl, L.; Gässler, W.; Borelli, J. L.

    2014-07-01

    ARGOS, a multi-star adaptive optics system is designed for the wide-field imager and multi-object spectrograph LUCI on the LBT (Large Binocular Telescope). Based on Rayleigh scattering the laser constellation images 3 artificial stars (at 532 nm) per each of the 2 eyes of the LBT, focused at a height of 12 km (Ground Layer Adaptive Optics). The stars are nominally positioned on a circle 2' in radius, but each star can be moved by up to 0.5' in any direction. For all of these needs are following main subsystems necessary: 1. A laser system with its 3 Lasers (Nd:YAG ~18W each) for delivering strong collimated light as for LGS indispensable. 2. The Launch system to project 3 beams per main mirror as a 40 cm telescope to the sky. 3. The Wave Front Sensor with a dichroic mirror. 4. The dichroic mirror unit to grab and interpret the data. 5. A Calibration Unit to adjust the system independently also during day time. 6. Racks + platforms for the WFS units. 7. Platforms and ladders for a secure access. This paper should mainly demonstrate how the ARGOS Laser System is configured and designed to support all other systems.

  19. OBIS - ARGOS Satellite Tracking of Animals

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Various species have been tracked using ARGOS PTT trackers since the early 1990's. These include Emperor, King and Adelie pengiuns, Light-mantled Sooty, Grey-headed...

  20. The Architecture of a Complex GIS & Spreadsheet Based DSS

    Directory of Open Access Journals (Sweden)

    Dinu Airinei

    2010-01-01

    Full Text Available The decision support applications available on today market use to combine the decision analysis of historical databased on On-Line Analytical Processing (OLAP products or spreadsheet pivot tables with some new reporting facilities as alerts or key performance indicators available in portal dashboards or in complex spreadsheet-like reports, both corresponding to a new approach of the field called Business Intelligence. Moreover the geographical features of GIS added to DSS applications become more and more required by many kinds of businesses. In fact they are more useful this way than as distinctive parts.The paper tries to present a certain DSS architecture based on the association between such approaches and technologies. The particular examples are meant to support all the theoretical arguments and to complete the understanding of the interaction schemas available.

  1. Argos Americano: incertidumbre e independencia

    Directory of Open Access Journals (Sweden)

    Julián Penagos Carreño

    2015-01-01

    Full Text Available El presente artículo es el resultado del análisis léxico métrico al periódico cartagenero el Argos Americano. Papel político, económico y literario de Cartagena de Indias (Septiembre de 1810 -Marzo de 1812 , que muestra las distintas discusiones que se dieron en torno a temas como nación, gobierno e independencia durante una época turbulenta cuando España había sido invadida por los ejércitos de Napoleón, y el rey Fernando VII fue hecho prisionero, lo cual dejó un vacío de poder que sumió a las provincias del continente americano en la incertidumbre por definir un gobierno. Este trabajo hace parte del proyecto de investigación Historia Cultural de la Prensa en la Nueva Granada ( 1810-1820 , patrocinado por la Dirección de Investigaciones y la Facultad de Comunicación de la Universidad de La Sabana.

  2. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  3. Multifrequency seismic detectability of seasonal thermoclines assessed from ARGO data

    Science.gov (United States)

    Ker, S.; Le Gonidec, Y.; Marié, L.

    2016-08-01

    Seismic oceanography is a developing research topic where new acoustic methods allow high-resolution teledetection of the thermohaline structure of the ocean. First implementations to study the Ocean Surface Boundary Layer have recently been achieved but remain very challenging due to the weakness and shallowness of such seismic reflectors. In this article, we develop a multifrequency seismic analysis of hydrographic data sets collected in a seasonally stratified midlatitude shelf by ARGO network floats to assess the detectability issue of shallow thermoclines. This analysis, for which sensitivity to the data reduction scheme used by ARGO floats for the transmission of the profiles is discussed, allows characterizing both the depth location and the frequency dependency of the dominant reflective feature of such complex structures. This approach provides the first statistical distribution of the range of variability of the frequency-dependent seismic reflection amplitude of the midlatitude seasonal thermoclines. We introduce a new parameter to quantify the overall capability of a multichannel seismic setup, including the source strength, the fold, and the ambient noise level, to detect shallow thermoclines. Seismic source signals are approximated by Ricker wavelets, providing quantitative guidelines to help in the design of seismic experiments targeting such oceanic reflectors. For shallow midlatitude seasonal thermoclines, we show that the detectability is optimal for seismic peak frequencies between 200 and 400 Hz: this means that airgun and Sparker sources are not well suited and that significant improvements of source devices will be necessary before seismic imaging of OSBL structures can be reliably attempted.

  4. 32 CFR 321.14 - DSS implementation policies.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DSS implementation policies. 321.14 Section 321...) PRIVACY PROGRAM DEFENSE SECURITY SERVICE PRIVACY PROGRAM § 321.14 DSS implementation policies. (a) General. The implementation of the Privacy Act of 1974 within DSS is as prescribed by DoD Directive...

  5. Design of the wavefront sensor unit of ARGOS, the LBT laser guide star system

    CERN Document Server

    Bonaglia, Marco

    2012-01-01

    ARGOS is the laser guide star ground layer adaptive optics system of the LBT. ARGOS is designed to bring a moderate but uniform reduction of the PSF size over a FoV as large as 4x4arcmin, allowing a significative increase of the science throughput of LUCI, the LBT NIR imager and MOS. ARGOS relays on 3 Rayleigh beacons to sense the lower layers of the atmosphere achieving almost 100% sky coverage. The ground layer AO correction is allowed by the 2 adaptive secondaries of the LBT. This PhD thesis first discusses a study based on numerical simulations and aimed to evaluate the performance of ARGOS. This work has been carried out using CAOS and representing in the code most of the features that characterize the system itself: as the laser beacon propagation in the atmosphere, the SH type wavefront sensing, the AO reconstruction and closed loop delays and the atmosphere tip-tilt sensing done using a NGS and a quad-cell type sensor. The results obtained in this study are in agreement and definitively confirm the pe...

  6. Impact of Argo Observation on the Regional Ocean Reanalysis of China Coastal Waters and Adjacent Seas: A Twin-Experiment Study

    Directory of Open Access Journals (Sweden)

    Caixia Shao

    2015-01-01

    Full Text Available A regional ocean reanalysis system of China coastal waters and adjacent seas, called CORA (China ocean reanalysis, has been recently developed at the National Marine Data and Information Service (NMDIS. In this study, based on CORA, the impact of Argo profiles on the regional reanalysis is evaluated using a twin-experiment approach. It is found that, by assimilating Argo observations, the reanalysis quality is much improved: the root mean square (RMS error of temperature and salinity can be further reduced by about 10% and the RMS error of current can be further reduced by 18%, compared to the case only assimilating conventional in situ temperature and salinity observations. Consistent with the unique feature of Argo observations, the temperature is improved in all levels and the largest improvement of salinity happens in the deep ocean. Argo profile data have a significant impact on the regional ocean reanalysis through improvements of both hydrographic and dynamic fields.

  7. ARGO-YBJ: Status and Highlights

    CERN Document Server

    Di Sciascio, G

    2012-01-01

    The ARGO-YBJ experiment is in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). ARGO-YBJ is facing open problems in Cosmic Ray (CR) physics in different ways. The search for CR sources is carried out by the observation of TeV gamma-ray sources both galactic and extra-galactic. The CR spectrum, composition and anisotropy are measured in a wide energy range (TeV - PeV) thus overlapping for the first time direct measurements. In this paper we summarize the current status of the experiment and describe some of the scientific highlights since 2007.

  8. The Impact of "Bad" Argo Profiles on Ocean Data Assimilation

    Institute of Scientific and Technical Information of China (English)

    YAN Chang-Xiang; ZHU Jiang

    2010-01-01

    Recent studies have found cold biases in a fraction of Argo profiles (hereinafter referred to as bad Array for Real-time Geostrophic Oceanography (Argo) profiles) due to the pressure drifts during 2003 and 2006. These bad Argo profiles have had an important impact on in situ observation-based global ocean heat content estimates. This study investigated the impact of bad Argo profiles on ocean data assimilation results that were based on observations from diverse ocean observation systems, such as in situ profiles (e.g., Argo, expendable bathythermograph (XBT), and Tropical Atmosphere Ocean (TAO), remote-sensing sea surface temperature products and satellite altimetry between 2004 and 2006. Results from this work show that the upper ocean heat content analysis is vulnerable to bad Argo profiles and demonstrate a cooling trend in the studied period despite the multiple independent data types that were assimilated. When the bad Argo profiles were excluded from the assimilation, the decreased heat content disappeared and a warming occurred. Combination of satellite altimetry and mass variation data from gravity satellite demonstrated an increase, which agrees well with the increased heat content. Additionally, when an additional Argo profile quality control procedure was utilized that simply removed the profiles that presented static unstable water columns, the results were very similar to those obtained when the bad Argo profiles were excluded from the assimilation. This indicates that an ocean data assimilation that uses multiple data sources with improved quality control could be less vulnerable to a major observation system failure, such as a bad Argo event.

  9. A Participants' DSS for a Management Game with a DSS Generator.

    Science.gov (United States)

    Yeo, Gee Kin; Nah, Fui Hoon

    1992-01-01

    Describes the design of a decision support system (DSS) for a management game called MAGNUS (Management Game for National University of Singapore). Built-in models for performance analysis and decision making are explained; database query and model building are described; and future work is discussed. (11 references) (LRW)

  10. Processed coffee alleviates DSS-induced colitis in mice

    Directory of Open Access Journals (Sweden)

    Bernd L. Fiebich

    2013-05-01

    Full Text Available ABSTRACTBackground: Coffee is one of the most widely consumed beverages in the world and it has been demonstrated that it has important therapeutic activities not only because of its caffeine content but also owing to the presence of other biologically active small molecules such as chlorogenic acid, trigonelline and cyclopentadiones. However, chlorogenic acid is degraded into catechol, pyrogallol and hydroxyhydroquinone, which are thought to induce irritation of the gastric mucosa. To reduce the content of irritant compounds processing methods have been developed prior to roasting the coffee beans.Objectives: The aim of this study was to study the anti-inflammatory and gastro-protective effects of processed coffee (Idee-Kaffee on in LPS-treated human primary monocytes and in a murine model of colon inflammation (IBD model.Results: In this study we have analyzed the effects on inflammatory events in cultured cells and in mice drinking a commercially available processed coffee. The processed coffee inhibited lipopolysaccharide (LPS-induced proinflammatory cytokines such as interleukin (IL-1, tumor necrosis factor (TNF, IL-6 and IL-8, and other inflammatory mediators such as prostaglandin (PGE2 and 8-isoprostane in cultured human primary monocytes. Oral administration of dissolved processed coffee, i.e., in its usual beverage form, improved greatly the adverse macroscopic and histological features of dextran sodium sulfate (DSS-induced colitis in mice in a dose-dependent manner. Processed coffee not only largely prevented DSS-induced colitis but also dramatically suppressed in vivo NF-B and STAT3 activities through inhibition of IB and STAT3 phosphorylation. Furthermore, this solubleFunctional Foods in Health and Disease 2013; 3(5:133-145coffee bean extract reduced the expression of proinflammatory cytokines TNF, IL-11, and IL-6 and the expression of cyclooxygenase (COX-2 in colonic tissues.Conclusions: This work identified

  11. Recent highlights from ARGO-YBJ

    Science.gov (United States)

    Di Sciascio, Di; ARGO-YBJ Collaboration

    2016-05-01

    The ARGO-YBJ experiment has been in stable data taking for more than 5 years at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.L, 606 g/cm2 ). With a duty-cycle of about 87% the detector collected more than 5×1011 events in a wide energy range, from few hundreds GeV up to 10 PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this talk we summarize the latest physics results obtained in gamma-ray astronomy and in cosmic ray physics.

  12. Highlights from the ARGO-YBJ experiment

    CERN Document Server

    ,

    2010-01-01

    The ARGO-YBJ experiment is a multipurpose detector exploiting the full coverage approach at very high altitude. The apparatus, in stable data taking since November 2007 with an energy threshold of a few hundreds of GeV and a duty-cycle of about 90 %, is located at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm2). A number of interesting results are available in Cosmic Ray Physics and in Gamma Ray Astronomy after the first 3 years of stable data taking. In this paper Gamma-Ray Astronomy results are summarized.

  13. Recent highlights from ARGO-YBJ

    CERN Document Server

    ,

    2014-01-01

    The ARGO-YBJ experiment has been in stable data taking for 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm^2). With a duty-cycle greater than 86% the detector collected about 5 X 10^{11} events in a wide energy range, from few hundreds GeV up to the PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this paper we summarize the latest results in gamma-ray astronomy and in cosmic ray physics

  14. Experience of the ARGO autonomous vehicle

    Science.gov (United States)

    Bertozzi, Massimo; Broggi, Alberto; Conte, Gianni; Fascioli, Alessandra

    1998-07-01

    This paper presents and discusses the first results obtained by the GOLD (Generic Obstacle and Lane Detection) system as an automatic driver of ARGO. ARGO is a Lancia Thema passenger car equipped with a vision-based system that allows to extract road and environmental information from the acquired scene. By means of stereo vision, obstacles on the road are detected and localized, while the processing of a single monocular image allows to extract the road geometry in front of the vehicle. The generality of the underlying approach allows to detect generic obstacles (without constraints on shape, color, or symmetry) and to detect lane markings even in dark and in strong shadow conditions. The hardware system consists of a PC Pentium 200 Mhz with MMX technology and a frame-grabber board able to acquire 3 b/w images simultaneously; the result of the processing (position of obstacles and geometry of the road) is used to drive an actuator on the steering wheel, while debug information are presented to the user on an on-board monitor and a led-based control panel.

  15. DSS1/Sem1, a multifunctional and intrinsically disordered protein

    DEFF Research Database (Denmark)

    Kragelund, Birthe Brandt; Schenstrøm, Signe Marie; Rebula, Caio A.;

    2016-01-01

    DSS1/Sem1 is a versatile intrinsically disordered protein. Besides being a bona fide subunit of the 26S proteasome, DSS1 associates with other protein complexes, including BRCA2-RPA, involved in homologous recombination; the Csn12-Thp3 complex, involved in RNA splicing; the integrator, involved...... in transcription; and the TREX-2 complex, involved in nuclear export of mRNA and transcription elongation. As a subunit of the proteasome, DSS1 functions both in complex assembly and possibly as a ubiquitin receptor. Here, we summarise structural and functional aspects of DSS1/Sem1 with particular emphasis on its...... multifunctional and disordered properties. We suggest that DSS1/Sem1 can act as a polyanionic adhesive to prevent nonproductive interactions during construction of protein assemblies, uniquely employing different structures when associating with the diverse multisubunit complexes....

  16. The DSS-14 C-band exciter

    Science.gov (United States)

    Rowan, D. R.

    1989-01-01

    The development and implementation of a C-band exciter for use with the Block IV Receiver-Exciter Subsystem at Deep Space Station 14 (DSS-14) has been completed. The exciter supplements the standard capabilities of the Block IV system by providing a drive signal for the C-band transmitter while generating coherent translation frequencies for C-band (5-GHz) to S-band (2.2- to 2.3-GHz) Doppler extraction, C-band to L-band (1.6-GHz) zero delay measurements, and a level calibrated L-band test signal. Exciter functions are described, and a general explanation and description of the C-band uplink controller is presented.

  17. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis.

    Directory of Open Access Journals (Sweden)

    Caitlyn W Barrett

    Full Text Available Selenium (Se is an essential micronutrient that exerts its functions via selenoproteins. Little is known about the role of Se in inflammatory bowel disease (IBD. Epidemiological studies have inversely correlated nutritional Se status with IBD severity and colon cancer risk. Moreover, molecular studies have revealed that Se deficiency activates WNT signaling, a pathway essential to intestinal stem cell programs and pivotal to injury recovery processes in IBD that is also activated in inflammatory neoplastic transformation. In order to better understand the role of Se in epithelial injury and tumorigenesis resulting from inflammatory stimuli, we examined colonic phenotypes in Se-deficient or -sufficient mice in response to dextran sodium sulfate (DSS-induced colitis, and azoxymethane (AOM followed by cyclical administration of DSS, respectively. In response to DSS alone, Se-deficient mice demonstrated increased morbidity, weight loss, stool scores, and colonic injury with a concomitant increase in DNA damage and increases in inflammation-related cytokines. As there was an increase in DNA damage as well as expression of several EGF and TGF-β pathway genes in response to inflammatory injury, we sought to determine if tumorigenesis was altered in the setting of inflammatory carcinogenesis. Se-deficient mice subjected to AOM/DSS treatment to model colitis-associated cancer (CAC had increased tumor number, though not size, as well as increased incidence of high grade dysplasia. This increase in tumor initiation was likely due to a general increase in colonic DNA damage, as increased 8-OHdG staining was seen in Se-deficient tumors and adjacent, non-tumor mucosa. Taken together, our results indicate that Se deficiency worsens experimental colitis and promotes tumor development and progression in inflammatory carcinogenesis.

  18. Hotelli Palace**** renoveerimine = Renovation of the hotel Palace**** / Argo Vaikla

    Index Scriptorium Estoniae

    Vaikla, Argo, 1966-

    2015-01-01

    Hotell Palace Tallinnas Vabaduse väljak 3, valminud 2014. Hoone rekonstrueerimisprojekt Reet Valk (AB Reet Valk), sisearhitektid Katrin Vaikla, Argo Vaikla, Mari-Liis Süld, Riin Luuk. 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  19. Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS in Mice Treated with FR91

    Directory of Open Access Journals (Sweden)

    Valter R. M. Lombardi

    2012-01-01

    Full Text Available One of the main treatments currently used in humans to fight cancer is chemotherapy. A huge number of compounds with antitumor activity are present in nature, and many of their derivatives are produced by microorganisms. However, the search for new drugs still represents a main objective for cancer therapy, due to drug toxicity and resistance to multiple chemotherapeutic drugs. In animal models, a short-time oral administration of dextran sulfate sodium (DSS induces colitis, which exhibits several clinical and histological features similar to ulcerative colitis (UC. However, the pathogenic factors responsible for DSS-induced colitis and the subsequent colon cancer also remain unclear. We investigated the effect of FR91, a standardized lysate of microbial cells belonging to the Bacillus genus which has been previously shown to have significant immunomodulatory effects, against intestinal inflammation. Colitis was induced in mice during 5 weeks by oral administration 2% (DSS. Morphological changes in the colonic mucosa were evaluated by hematoxylin-eosin staining and immunohistochemistry methods. Adenocarcinoma and cryptal cells of the dysplastic epithelium showed cathenin-β, MLH1, APC, and p53 expression, together with increased production of IFN-γ. In our model, the optimal dose response was the 20% FR91 concentration, where no histological alterations or mild DSS-induced lesions were observed. These results indicate that FR91 may act as a chemopreventive agent against inflammation in mice DSS-induced colitis.

  20. Grim19 Attenuates DSS Induced Colitis in an Animal Model.

    Science.gov (United States)

    Kim, Jae-Kyung; Lee, Seung Hoon; Lee, Seon-Young; Kim, Eun-Kyung; Kwon, Jeong-Eun; Seo, Hyeon-Beom; Lee, Han Hee; Lee, Bo-In; Park, Sung-Hwan; Cho, Mi-La

    2016-01-01

    DSS induced colitis is a chronic inflammatory disease characterized by inflammation in the gastrointestinal tract, which destabilizes the gut and induces an uncontrolled immune response. Although DSS induced colitis is generally thought to develop as a result of an abnormally active intestinal immune system, its pathogenesis remains unclear. Gene associated with retinoid interferon induced mortality (Grim) 19 is an endogenous specific inhibitor of STAT3, which regulates the expression of proinflammatory cytokines. In this study, we investigated the influence of GRIM19 in a DSS induced colitis mouse model. We hypothesized that Grim19 would ameliorate DSS induced colitis by altering STAT3 activity and intestinal inflammation. Grim19 ameliorated DSS induced colitis severity and protected intestinal tissue. The expression of STAT3 and proinflammatory cytokines such as IL-1β and TNF-α in colon and lymph nodes was decreased significantly by Grim19. Moreover, DSS induced colitis progression in a Grim19 transgenic mouse line was inhibited in association with a reduction in STAT3 and IL-17 expression. These results suggest that Grim19 attenuates DSS induced colitis by suppressing the excessive inflammatory response mediated by STAT3 activation.

  1. Implementing a decision support system (DSS in e-business

    Directory of Open Access Journals (Sweden)

    Alexandra Ruiz G.

    2010-05-01

    Full Text Available Decision support systems (DSS and e-business (EB have emerged as separate areas. However, currently, and for some years now, DSS and EB have become merged to provide customers with greater benefits and added value. There are different types of DSS and different categories and business models for EB; one area’s applicability to the other thus expands the possible combi- nations which can arise from such different categories. Some representative examples would include auction sites which, through applying intelligent agents, can learn about which products to offer or when and where to sell them; DSS allow a company’s in- formation avilable in web portals for customers and employees to be accessed in a controlled way and decisions thus made; vir- tual stores may be positively affected by data mining and data warehousing being applied; complex algorithms could be used in customer relationship management for predicting and analysing “what would happen if” to identify revenue opportunities in com- petitive markets; and a wide range of other applications where imagination is the limit. Research into DSS / BE must be ongoing due to the constant emergence of new business models and DSS subsystems. Applications can be varied and provide bi-directio- nal support for each one. New interaction mechanisms and efforts to satisfy customers are also the focus of inspiration for new applications for DSS systems in EB.

  2. Argos: An Optimized Time-Series Photometer

    Indian Academy of Sciences (India)

    Anjum S. Mukadam; R. E. Nather

    2005-06-01

    We designed a prime focus CCD photometer, Argos, optimized for high speed time-series measurements of blue variables (Nather & Mukadam 2004) for the 2.1 m telescope at McDonald Observatory. Lack of any intervening optics between the primary mirror and the CCD makes the instrument highly efficient.We measure an improvement in sensitivity by a factor of nine over the 3-channel PMT photometers used on the same telescope and for the same exposure time. The CCD frame transfer operation triggered by GPS synchronized pulses serves as an electronic shutter for the photometer. This minimizes the dead time between exposures, but more importantly, allows a precise control of the start and duration of the exposure. We expect the uncertainty in our timing to be less than 100 s.

  3. Cosmic Ray physics with ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Iacovacci, M. [Dipartimento di Fisica dell' Università di Napoli ”Federico II” and INFN Napoli, Complesso Universitario MSA, Via Cintia, 80126 Napoli (Italy)

    2013-06-15

    The ARGO-YBJ experiment has been in stable data taking from November 2007 till February 2013 at the Yang-BaJing Cosmic Ray Laboratory (Tibet, P.R.China, 4300 m a.s.l.). It exploits the full coverage and the high altitude to detect air showers with an energy threshold as low as a few hundred GeV. The detector is made of a single layer of RPCs operated in streamer mode, fully instrumenting a central carpet of about 5800 m{sup 2}. A guard ring extends the partially instrumented area to about 11,000 m{sup 2}. The main results so far achieved on Cosmic Ray physics are reported.

  4. Cosmic ray physics with ARGO-YBJ

    CERN Document Server

    ,

    2016-01-01

    The ARGO--YBJ experiment has been in stable data taking for more than five years at the Yangbajing cosmic ray observatory (Tibet, P.R. China, 4300 m a.s.l.). The detector collected about $5\\times10^{11}$ events in a wide energy range from few TeVs up to the PeV region. In this work we summarize the latest results in cosmic ray physics particularly focusing on the cosmic ray energy spectrum. The results of the measurement of the all-particle and proton plus helium energy spectra in the energy region between $10^{12} - 10^{16}$ eV are discussed. A precise measurement of the cosmic ray energy spectrum and composition in this energy region allows a better understanding of the origin of the knee and provides a powerful cross-check among different experimental techniques.

  5. DSS and GIS in Knowledge Transformation Process

    Directory of Open Access Journals (Sweden)

    Klimešová Dana

    2009-06-01

    Full Text Available Knowledge is an important resource for successful decision-making process in the whole society today. The special procedures of control and management of knowledge therefore have to be used. In the area of knowledge management and knowledge engineering basic terms of these disciplines are data, information, knowledge and knowledge transformation. The knowledge can be defined as a dynamic human process of justifying personal beliefs. Knowledge is a product of successful decision-making process. Knowledge transformation is a spiralling process of interactions between explicit and tacit knowledge that leads to the new knowledge. Nonaka and all show, that the combination of these two categories makes possible to conceptualise four conversion steps: Socialisation, Externalisation, Combination and Internalisation (SECI model. Another model of knowledge creation is the Knowledge Transformation Continuum (BCI Knowledge Group that begins with the articulation of a specific instruction representing the best way that a specific task, or series of tasks, should be performed. Knowledge modelling and knowledge representation is an important field of research also in Computer Science and Artificial Intelligence. The definition of knowledge in Artificial Intelligence is a noticeable different, because Artificial Intelligence is typically dealing with formalized knowledge (e.g. ontology. The development of knowledge-based systems was seen as a process of transferring human knowledge to an implemented knowledge base. Decision Support Systems (DSS, Geographical Information Systems (GIS and Operations Research/Management Science (OR/MS modelling process support decision-making process, therefore they also produce a new knowledge. A Decision Support Systems are an interactive computer-based systems helping decision makers complete decision process. Geographic Information Systems provide essential marketing and customer intelligence solutions that lead to better

  6. Environmental Resources Analysis System, A Prototype DSS

    Science.gov (United States)

    Flug, M.; Campbell, S.G.; Bizier, P.; DeBarry, P.

    2003-01-01

    Since the 1960's, an increase in the public's environmental ethics, federal species preservation, water quality protection, and interest in free flowing rivers have evolved to the current concern for stewardship and conservation of natural resources. This heightened environmental awareness creates an appetite for data, models, information management, and systematic analysis of multiple scientific disciplines. A good example of this information and analysis need resides in the Green and Yampa Rivers, tributary to the Upper Colorado River. These rivers are home to endangered native fish species including the pikeminnow and razorback sucker. Two dams, Fontenelle and Flaming Gorge, impound the Green River headwaters. The respective reservoirs store water supplies as well as generate hydropower. Conversely, the Yampa River is considered unregulated and encompasses most of Dinosaur National Monument. Recreation is highly regarded on both rivers including fishing, whitewater rafting, and aesthetic values. Vast areas of irrigated agriculture, forestry, and mineral extraction also surround these rivers. To address this information need, we developed a prototype Environmental Resources Analysis System (ERAS) spreadsheet-based decision support system (DSS). ERAS provides access to historic data sets, scientific information, statistical analysis, model outputs, and comparative methods all in a familiar and user-friendly format. This research project demonstrates a simplified decision support system for use by a diverse mix of resource managers, special interest groups, and individuals concerned about the sustainability of the Green and Yampa River ecosystem.

  7. PCI DSS a practical guide to implementing and maintaining compliance

    CERN Document Server

    Wright, Steve

    2011-01-01

    This newly revised, practical guide, gives you a step by step guide to achieving Payment Card Industry Data Security Standard (PCI DSS) compliance - showing you how to create, design and build a PCI compliance framework.

  8. Text-mining-assisted biocuration workflows in Argo.

    Science.gov (United States)

    Rak, Rafal; Batista-Navarro, Riza Theresa; Rowley, Andrew; Carter, Jacob; Ananiadou, Sophia

    2014-01-01

    Biocuration activities have been broadly categorized into the selection of relevant documents, the annotation of biological concepts of interest and identification of interactions between the concepts. Text mining has been shown to have a potential to significantly reduce the effort of biocurators in all the three activities, and various semi-automatic methodologies have been integrated into curation pipelines to support them. We investigate the suitability of Argo, a workbench for building text-mining solutions with the use of a rich graphical user interface, for the process of biocuration. Central to Argo are customizable workflows that users compose by arranging available elementary analytics to form task-specific processing units. A built-in manual annotation editor is the single most used biocuration tool of the workbench, as it allows users to create annotations directly in text, as well as modify or delete annotations created by automatic processing components. Apart from syntactic and semantic analytics, the ever-growing library of components includes several data readers and consumers that support well-established as well as emerging data interchange formats such as XMI, RDF and BioC, which facilitate the interoperability of Argo with other platforms or resources. To validate the suitability of Argo for curation activities, we participated in the BioCreative IV challenge whose purpose was to evaluate Web-based systems addressing user-defined biocuration tasks. Argo proved to have the edge over other systems in terms of flexibility of defining biocuration tasks. As expected, the versatility of the workbench inevitably lengthened the time the curators spent on learning the system before taking on the task, which may have affected the usability of Argo. The participation in the challenge gave us an opportunity to gather valuable feedback and identify areas of improvement, some of which have already been introduced. Database URL: http://argo.nactem.ac.uk.

  9. ARGO-YBJ data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    Aloisio, A. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy); Branchini, P. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Budano, A. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Catalanotti, S. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy); Creti, P. [Dipartimento di Ingegneria, Universita degli Studi di Lecce and INFN, Lecce (Italy); Galeazzi, F. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Marsella, G. [Dipartimento di Ingegneria, Universita degli Studi di Lecce and INFN, Lecce (Italy); Mastroianni, S. [Dipartimento di Fisica, Universita ' Federico II' and INFN, Naples (Italy)]. E-mail: Stefano.Mastroianni@na.infn.it; Ruggieri, F. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy); Stanescu, C. [Dipartimento di Fisica, Universita Roma Tre and INFN, Rome (Italy)

    2006-12-01

    The ARGO-YBJ experiment is reaching its final design configuration. An array of single layer Resistive Plate Counters (RPCs) covering an area of {approx}5800m{sup 2} will collect a huge amount of data. The throughput required from the final detector strongly depends on the trigger rate. The DAQ system must be able to sustain a data transfer rate estimated to be the order of 15MB/s and a high peak of data flow. Data are read out using a typical front-end acquisition chain built around a custom bus. Specialized electronics have been designed and efficient software had to be written to perform this task. Data are then sent to the on-line farm through a switch exploiting gigabit-ethernet protocol. In this paper we will describe the design of the DAQ system, the software which deals with data collection and network sending and the performances. The architecture of the on-line farm is also described together with the monitoring system.

  10. Sky monitoring with ARGO-YBJ

    CERN Document Server

    Vernetto, S; Zhang, J L

    2009-01-01

    A sky monitoring at gamma ray energy E > 0.6 TeV has been performed by the full coverage Extensive Air Shower detector ARGO-YBJ, located in Tibet at 4300 m of altitude. We monitored 135 galactic and extragalactic gamma ray sources in the sky declination band from -10 to +70 degrees for 424 days, detecting the Crab Nebula and Mrk421 with a significance respectively of 7.0 and 8.0 standard deviations. For a set of 11 AGNs known to emit in the TeV energy range, the search has been performed in time scales of 1, 10 and 30 days in order to study possible flaring activities. Significant emissions has been observed from Mrk421 in the time scales of 10 and 30 days, during June and March 2008, when the source had a strong activity also observed in the X-rays waveband. The analysis of the background has revealed the existence of a significant excess of the CR flux in two localized regions of angular size 10-30 degrees, in agreement with previous indications.

  11. Meso-scale circulation at the intermediate-depth east of Mindanao observed by Argo profiling floats

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The meso-scale circulation at the intermediate depth east of Mindanao is studied using Argo profiling floats observations. The trajectories and the parking-depth velocities of Argo floats show that the intermediate-depth circulation east of Mindanao contains significant meso-scale features that are highly variable both in space and in time. Both cyclonic and anticyclonic eddies at the intermediate depth (1000–2000 m) are indicated by the trajectories east of Mindanao. The mean tangential velocities of these eddies are about 10 cm/s at 2000 m and over 20 cm/s at 1000 m, which indicates that the geostrophic calculation may contain large errors due to the vigorous eddy activity at the reference levels. The analyses also suggest that these eddies might play an important role in mass and vorticity balances of the intermediate-depth circulation east of Mindanao.

  12. Dextran sulfate sodium (DSS)-induced colitis in mice.

    Science.gov (United States)

    Chassaing, Benoit; Aitken, Jesse D; Malleshappa, Madhu; Vijay-Kumar, Matam

    2014-02-04

    Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed. This protocol describes the DSS-induced colitis model, focusing on details and factors that could affect DSS-induced pathology.

  13. DSS-13 S-/X-band microwave feed system

    Science.gov (United States)

    Manshadi, F.

    1994-05-01

    The configuration, detail design, and performance of the dual S-/X-band microwave feed system for the new DSN beam-waveguide antenna, Deep Space Station (DSS) 13, are reported. By using existing spare components, reducing fabrication cost of new components by simplifying their design, and using new fabrication techniques and material, this DSS-13 feed system was implemented successfully with a small budget and a very tight schedule. Measured noise temperature gains of the feed system are 17.5 K for S-band (2200-2300 MHz) and 24.0 K for X-band (8200-8600 MHz), which agree very closely with the predicted performance.

  14. Validation of argo data in the Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Pankajakshan, T.; Muraleedharan, P.M.; Gopalakrishna, V.V.; Reddy, G.V.; Ratnakaran, L.; Revichandran, C.; Murty, V.S.N

    ARGO-salinity data from the Indian Ocean are validated using salinity from float-versus-float match-ups and also using CTD observations from three cruises. Validation data sets are selected in such a way that the float and the match-up data...

  15. Implementation of SLODAR atmospheric turbulence profiling to the ARGOS system

    Science.gov (United States)

    Mazzoni, Tommaso; Busoni, Lorenzo; Bonaglia, Marco; Esposito, Simone

    2014-08-01

    ARGOS is the Ground Layer Adaptive Optics system of the Large Binocular Telescope, it uses three Laser Guide Stars at 12 km altitude, generated by Rayleigh backscattered light of pulsed Nd:YAG lasers at 532nm. The wavefront distortion in the Ground Layer is measured by three Shack-Hartmann WFS, sampling with 15×15 subaperture the three LGS arranged on a single CCD with 8×8px per square subaperture. The SLOpe Detection And Ranging (SLODAR) is a method used to measure the turbulence profiles. Cross correlation of wavefronts gradient from multiple stars is used to estimate the relative strengths of turbulent layers at different altitudes. In the ARGOS case the LGS are arranged on a triangle inscribed in a 2 arcmin radius circle, so we expect an effective slopes correlation up to 5km altitude. We present here the results of a study aimed to implement the SLODAR method on ARGOS performed with the idl-based simulation code used to characterize the ARGOS performance. Simulation implements the atmospheric turbulence on different layers with variable strength, altitude and wind speed. The algorithm performance are evaluated comparing the input turbulence with the cross-correlation of the SH slopes acquired in open loop.

  16. Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction[OPEN

    Science.gov (United States)

    Shi, Jinrui; Wang, Hongyu; Habben, Jeffrey E.

    2016-01-01

    The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize. PMID:27268962

  17. 会计DSS: 决策支持系统在会计学中的应用%Accounting DSS: an Application of DSS to Accounting

    Institute of Scientific and Technical Information of China (English)

    戴悦; 岳超源

    1999-01-01

    探讨了将决策支持系统运用于会计学的问题.分析并提供了会计DSS的基本框架及组成,并以实例展示了会计DSS是如何支持决策的,可作为企业运用DSS 进行会计决策之借鉴.

  18. AOM/DSS Model of Colitis-Associated Cancer.

    Science.gov (United States)

    Parang, Bobak; Barrett, Caitlyn W; Williams, Christopher S

    2016-01-01

    Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.

  19. A DSS for capacity planning of aircraft maintenance personnel

    NARCIS (Netherlands)

    M.C. Dijkstra (Matthijs); L.G. Kroon (Leo); J.A.E.E. van Nunen (Jo); M. Salomon (Marc)

    1991-01-01

    textabstractIn this paper we describe a Decision Support System (DSS) that has been developed for the aircraft maintenance department of the Dutch national airline company at the main airport in the Netherlands. The aircraft maintenance department is responsible for carrying out the regular short in

  20. 32 CFR 321.8 - DSS review of request for amendment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DSS review of request for amendment. 321.8... (CONTINUED) PRIVACY PROGRAM DEFENSE SECURITY SERVICE PRIVACY PROGRAM § 321.8 DSS review of request for... correspondence. (b) DSS determination to approve or deny. Determination to approve or deny and request to amend...

  1. Identification of the TeV gamma-ray source ARGO J2031+4157 with the Cygnus Cocoon

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S.; D' Ettorre Piazzoli, B.; Di Girolamo, T. [Dipartimento di Fisica dell' Università di Napoli " Federico II," Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A.; De Mitri, I. [Dipartimento Matematica e Fisica " Ennio De Giorgi," Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Camarri, P. [Dipartimento di Fisica dell' Università di Roma " Tor Vergata," via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R.; Di Sciascio, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z., E-mail: chensz@ihep.ac.cn [Yunnan University, 2 North Cuihu Road, 650091 Kunming, Yunnan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2014-08-01

    The extended TeV gamma-ray source ARGO J2031+4157 (or MGRO J2031+41) is positionally consistent with the Cygnus Cocoon discovered by Fermi-LAT at GeV energies in the Cygnus superbubble. Reanalyzing the ARGO-YBJ data collected from 2007 November to 2013 January, the angular extension and energy spectrum of ARGO J2031+4157 are evaluated. After subtracting the contribution of the overlapping TeV sources, the ARGO-YBJ excess map is fitted with a two-dimensional Gaussian function in a square region of 10° × 10°, finding a source extension σ{sub ext}= 1.°8 ± 0.°5. The observed differential energy spectrum is dN/dE = (2.5 ± 0.4) × 10{sup –11}(E/1 TeV){sup –2.6±0.3} photons cm{sup –2} s{sup –1} TeV{sup –1}, in the energy range 0.2-10 TeV. The angular extension is consistent with that of the Cygnus Cocoon as measured by Fermi-LAT and the spectrum also shows a good connection with the one measured in the 1-100 GeV energy range. These features suggest to identify ARGO J2031+4157 as the counterpart of the Cygnus Cocoon at TeV energies. The Cygnus Cocoon, located in the star-forming region of Cygnus X, is interpreted as a cocoon of freshly accelerated cosmic rays related to the Cygnus superbubble. The spectral similarity with supernova remnants (SNRs) indicates that the particle acceleration inside a superbubble is similar to that in an SNR. The spectral measurements from 1 GeV to 10 TeV allows for the first time to determine the possible spectrum slope of the underlying particle distribution. A hadronic model is adopted to explain the spectral energy distribution.

  2. Lactobacillus crispatus M206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

    Institute of Scientific and Technical Information of China (English)

    Fu-Xi Zhou; Lu Chen; Xiao-Wei Liu; Chun-Hui Ouyang; Xiao-Ping Wu; Xue-Hong Wang; Chun-Lian Wang

    2012-01-01

    AIM:To investigate the role of Lactobacillus crispatus (L.crispatus) strain China Center for Type Culture Collection (CCTCC) M206119 in intestinal inflammation.METHODS:Forty 8-wk-old Balb/c mice (20 ± 2 g)were divided into four groups of 10 mice each.Three groups that had received dextran sulfate sodium (DSS)were administered normal saline,sulfasalazine or CCTCC M206119 strain,and the fourth group received none of these.We assessed the severity of colitis using a disease activity index,measured the colon length and weight,collected stools and mesenteric lymph nodes for bacterial microflora analysis.One centimeter of the proximal colon,middle colon and distal colon were collected and fixed in 10% buffered formalin,dehydrated in ethanol,and embedded in paraffin.Interleukin (IL)-1β,IL-6 and tumor necrosis factor (TNF)-α expression was detected using reverse transcription polymerase chain reaction.Protective factors zonula occludens (ZO)-1 and β-defensin 2 were detected by immunoblotting.The features of CCTCC M206119 strain were identified based on morphology,biochemical profile,and 16S RNA sequencing.RESULTS:DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease,with greater weight loss,diarrhea,fecal bleeding,and shortened colon length.In addition,the CCTCC-M206119-treated group had comparatively higher histological scores and more neutrophil infiltration than the controls.Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment.An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells.Intestinal proinflammatory or anti-inflammatory cytokine responses were evaluated.Proinflammatory colonic cytokine (IL-1β,IL-6and TNF-α) levels were clearly increased in CCTCC-M206119-treated animals,whereas anti-inflammatory colonic cytokine (IL-10) level was lowered compared with

  3. Scaler Mode Technique for the ARGO-YBJ Detector

    CERN Document Server

    Aielli, G

    2008-01-01

    The ARGO-YBJ experiment has been designed to study the Extensive Air Showers with an energy threshold lower than that of the existing arrays by exploiting the high altitude location(4300 m a.s.l. in Tibet, P.R. China) and the full ground plane coverage. The lower energy limit of the detector (E $\\sim$ 1 GeV) is reached by the scaler mode technique, i.e. recording the counting rate at fixed time intervals. At these energies, transient signals due to local (e.g. Forbush Decreases) and cosmological (e.g. Gamma Ray Bursts) phenomena are expected as a significant variation of the counting rate compared to the background. In this paper the performance of the ARGO-YBJ detector operating in scaler mode is described and discussed.

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-11-14 for the Global Argo Data Repository, date ranged from 2003-01-29 to 2004-11-20 (NODC Accession 0001906)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo project...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of October 2003 for the Global Argo Data Repository, 1996-01-05 to 2003-10-31 (NODC Accession 0001217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-10-26 for the Global Argo Data Repository, date ranged from 2003-03-12 to 2003-11-01 (NODC Accession 0001216)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-07-22 for the Global Argo Data Repository, date ranged from 2002-05-16 to 2007-07-28 (NODC Accession 0031203)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-12-24 for the Global Argo Data Repository, date ranged from 2004-02-23 to 2006-12-30 (NODC Accession 0012522)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-04-08 for the Global Argo Data Repository, date ranged from 2002-08-20 to 2010-04-14 (NODC Accession 0063066)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-05-02 for the Global Argo Data Repository, date ranged from 2000-11-22 to 2004-05-08 (NODC Accession 0001453)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-03-25 for the Global Argo Data Repository, date ranged from 2001-07-30 to 2010-03-30 (NODC Accession 0062945)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-04-27 for the Global Argo Data Repository, date ranged from 2002-12-22 to 2003-05-03 (NODC Accession 0001008)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  13. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-01-09 for the Global Argo Data Repository, 2000-03-01 to 2005-01-15 (NODC Accession 0001981)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-05-06 for the Global Argo Data Repository, date ranged from 2001-01-21 to 2010-05-12 (NODC Accession 0064275)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  15. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-11-27 for the Global Argo Data Repository, date ranged from 2000-06-01 to 2008-12-03 (NODC Accession 0049080)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-05-06 for the Global Argo Data Repository, date ranged from 2002-12-02 to 2007-05-12 (NODC Accession 0015504)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-04-08 for the Global Argo Data Repository, date ranged from 2005-02-25 to 2007-04-14 (NODC Accession 0014769)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  18. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-06-10 for the Global Argo Data Repository, date ranged from 2004-06-08 to 2010-06-16 (NODC Accession 0065228)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-04-30 for the Global Argo Data Repository, date ranged from 2002-03-08 to 2006-05-06 (NODC Accession 0002664)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-08-20 for the Global Argo Data Repository, date ranged from 2004-03-05 to 2006-08-26 (NODC Accession 0002810)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-09-02 for the Global Argo Data Repository, date ranged from 2001-05-24 to 2010-09-07 (NODC Accession 0067578)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository(GADR as the long-term archive for the International Global Argo Project...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-03-18 for the Global Argo Data Repository, date ranged from 2001-08-26 to 2010-03-24 (NODC Accession 0062812)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2008-02-10 for the Global Argo Data Repository, date ranged from 2002-06-21 to 2008-02-16 (NODC Accession 0038996)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-02-26 for the Global Argo Data Repository, date ranged from 2001-12-12 to 2006-03-04 (NODC Accession 0002591)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-11-28 for the Global Argo Data Repository, date ranged from 2000-10-30 to 2004-12-04 (NODC Accession 0001927)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-07-15 for the Global Argo Data Repository, date ranged from 2000-01-05 to 2007-07-21 (NODC Accession 0029221)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  7. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2006-09-10 for the Global Argo Data Repository, date ranged from 2000-07-15 to 2006-09-16 (NODC Accession 0005979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  8. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-01-23 for the Global Argo Data Repository, 2002-12-03 to 2005-01-29 (NODC Accession 0002001)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  9. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-11-05 for the Global Argo Data Repository, date ranged from 1999-10-25 to 2009-11-11 (NODC Accession 0059419)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-03-18 for the Global Argo Data Repository, date ranged from 2004-01-28 to 2007-03-24 (NODC Accession 0014265)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-06-24 for the Global Argo Data Repository, date ranged from 2001-11-22 to 2007-06-30 (NODC Accession 0020914)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-05-08 for the Global Argo Data Repository, date ranged from 1998-06-16 to 2005-07-09 (NODC Accession 0002272)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  13. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of January 2005 for the Global Argo Data Repository, 1996-01-05 to 2005-01-31 (NODC Accession 0002005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  14. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-07-03 for the Global Argo Data Repository, date ranged from 2002-08-02 to 2008-07-09 (NODC Accession 0043301)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  15. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2005-07-10 for the Global Argo Data Repository, date ranged from 1999-10-22 to 2005-07-17 (NODC Accession 0002281)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  16. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-02-18 for the Global Argo Data Repository, date ranged from 2001-09-30 to 2010-02-24 (NODC Accession 0062336)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  17. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-11-26 for the Global Argo Data Repository, date ranged from 2001-12-21 to 2009-12-02 (NODC Accession 0059941)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  18. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of October 2007 for the Global Argo Data Repository, 1995-09-07 to 2007-10-31 (NODC Accession 0036822)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  19. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-05-28 for the Global Argo Data Repository, date ranged from 2002-02-05 to 2009-06-02 (NODC Accession 0054265)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  20. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of May 2005 for the Global Argo Data Repository, 1996-01-05 to 2005-05-31 (NODC Accession 0002210)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  1. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of June 2007 for the Global Argo Data Repository, 1996-01-05 to 2007-07-01 (NODC Accession 0020937)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2010-02-25 for the Global Argo Data Repository, date ranged from 2002-08-06 to 2010-03-03 (NODC Accession 0062541)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  3. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-12-24 for the Global Argo Data Repository, date ranged from 2002-02-15 to 2009-12-30 (NODC Accession 0060860)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  4. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-05-13 for the Global Argo Data Repository, date ranged from 2002-12-02 to 2007-05-19 (NODC Accession 0015775)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  5. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2004-01-25 for the Global Argo Data Repository, date ranged from 2004-01-05 to 2004-01-31 (NODC Accession 0001358)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  6. Temperature and salinity profile data from globally distributed Argo profiling floats for the month of December 2006 for the Global Argo Data Repository, 1996-01-05 to 2006-12-31 (NODC Accession 0012523)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  7. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-07-10 for the Global Argo Data Repository, date ranged from 2007-12-18 to 2008-07-17 (NODC Accession 0043460)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  8. Temperature and salinity profile data from globally distributed Argo profiling for the week of 2008-03-02 for the Global Argo Data Repository, date ranged from 2002-03-30 to 2008-03-11 (NODC Accession 0039531)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  9. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-06-05 for the Global Argo Data Repository, date ranged from 2006-10-08 to 2008-06-11 (NODC Accession 0042829)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR)as the long-term archive for the International Global Argo Project...

  10. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-03-12 for the Global Argo Data Repository, date ranged from 1998-12-08 to 2009-03-18 (NODC Accession 0002061)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  11. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-05-11 for the Global Argo Data Repository, date ranged from 2003-04-26 to 2003-05-17 (NODC Accession 0001030)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  12. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2003-04-06 for the Global Argo Data Repository, date ranged from 2002-01-02 to 2003-04-12 (NODC Accession 0000994)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  13. Temperature and Salinity profile data from globally distributed Argo profiling floats for the week of 2008-11-20 for the Global Argo Data Repository, date ranged from 2000-02-01 to 2008-11-26 (NODC Accession 0048970)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR as the long-term archive for the International Global Argo Project...

  14. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2007-03-11 for the Global Argo Data Repository, date ranged from 2000-06-03 to 2007-03-17 (NODC Accession 0014118)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo Project...

  15. Overview of the ARGOS X-ray framing camera for Laser MegaJoule

    Energy Technology Data Exchange (ETDEWEB)

    Trosseille, C., E-mail: clement.trosseille@cea.fr; Aubert, D.; Auger, L.; Bazzoli, S.; Brunel, P.; Burillo, M.; Chollet, C.; Jasmin, S.; Maruenda, P.; Moreau, I.; Oudot, G.; Raimbourg, J.; Soullié, G.; Stemmler, P.; Zuber, C. [CEA, DAM, DIF, F-91297 Arpajon (France); Beck, T. [CEA, DEN, CADARACHE, F-13108 St Paul lez Durance (France); Gazave, J. [CEA, DAM, CESTA, F-33116 Le Barp (France)

    2014-11-15

    Commissariat à l’Énergie Atomique et aux Énergies Alternatives has developed the ARGOS X-ray framing camera to perform two-dimensional, high-timing resolution imaging of an imploding target on the French high-power laser facility Laser MegaJoule. The main features of this camera are: a microchannel plate gated X-ray detector, a spring-loaded CCD camera that maintains proximity focus in any orientation, and electronics packages that provide remotely-selectable high-voltages to modify the exposure-time of the camera. These components are integrated into an “air-box” that protects them from the harsh environmental conditions. A miniaturized X-ray generator is also part of the device for in situ self-testing purposes.

  16. Gamma-Ray Astronomy with ARGO-YBJ

    CERN Document Server

    Di Sciascio, G

    2011-01-01

    ARGO-YBJ is a full coverage air shower array located at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm^2) recording data with a duty cycle $\\geq$85% and an energy threshold of a few hundred GeV. In this paper the latest results in Gamma-Ray Astronomy are summarized.

  17. Physics Results from the Argo-YBJ Experiment

    CERN Document Server

    Di Sciascio, G

    2008-01-01

    The ARGO-YBJ experiment has been in stable data taking since November 2007 at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l.). In this paper we report a few selected results in Gamma-Ray Astronomy (Crab Nebula and Mrk421 observations, search for high energy tails of GRBs) and Cosmic Ray Physics (Moon and Sun shadow observations, proton-air cross section and antiproton/proton preliminary measurements).

  18. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis.

    Science.gov (United States)

    Jang, Jong-Chan; Lee, Kang Min; Ko, Seong-Gyu

    2016-01-01

    We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis. Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days. Oral administration of AAK extract (500 mg/kg/day) significantly alleviated DSS-induced symptoms such as anorexia, weight loss, events of diarrhea or bloody stools, and colon shortening. Histological damage was also ameliorated, as evidenced by the architectural preservation and suppression of inflammatory cell infiltration in colonic samples. Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins. In the isolated serum, IgE levels were downregulated. Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis.

  19. A method to manage the model base in DSS

    Institute of Scientific and Technical Information of China (English)

    孙成双; 李桂君

    2004-01-01

    How to manage and use models in DSS is a most important subject. Generally, it costs a lot of money and time to develop the model base management system in the development of DSS and most are simple in function or cannot be used efficiently in practice. It is a very effective, applicable, and economical choice to make use of the interfaces of professional computer software to develop a model base management system. This paper presents the method of using MATLAB, a well-known statistics software, as the development platform of a model base management system. The main functional framework of a MATLAB-based model base managementsystem is discussed. Finally, in this paper, its feasible application is illustrated in the field of construction projects.

  20. Intelligent remote health monitoring using evident-based DSS for automated assistance.

    Science.gov (United States)

    Serhani, Mohamed Adel; Benharref, Abdelghani; Nujum, Al Ramzana

    2014-01-01

    The shift from common diagnosis practices to continuous monitoring based on body sensors has transformed healthcare from hospital-centric to patient-centric. Continuous monitoring generates huge and continuous amount of data revealing changing insights. Existing approaches to analyze streams of data in order to produce validated decisions relied mostly on static learning and analytics techniques. In this paper, we propose an incremental learning and adaptive analytics scheme relying on evident data and rule-based Decision Support System (DSS). The later continuously enriches its knowledge base with incremental learning information impacting the decision and proposing up-to-date recommendations. Some intelligent features augmented the monitoring scheme with data pre-processing and cleansing support, which helped empowering data analytics efficiency. Generated assistances are viewable to users on their mobile devices and to physician via a portal. We evaluate our incremental learning and analytics scheme using seven well-known learning techniques. The set of experimental scenarios of continuous heart rate and ECG monitoring demonstrated that the incremental learning combined with rule-based DSS afforded high classification accuracy, evidenced decision, and validated assistance.

  1. Negative regulation of DSS-induced experimental colitis by PILRα.

    Science.gov (United States)

    Kishida, Kazuki; Kohyama, Masako; Kurashima, Yosuke; Kogure, Yuta; Wang, Jing; Hirayasu, Kouyuki; Suenaga, Tadahiro; Kiyono, Hiroshi; Kunisawa, Jun; Arase, Hisashi

    2015-06-01

    Inflammatory bowel disease is thought to be a complex multifactorial disease, in which an increased inflammatory response plays an important role. Paired immunoglobulin-like type 2 receptor α (PILRα), well conserved in almost all mammals, is an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain. PILRα is mainly expressed on myeloid cells and plays an important role in the regulation of inflammation. In the present study, we investigated the function of PILRα in inflammatory bowel disease using PILRα-deficient mice. When mice were orally administered dextran sulfate sodium (DSS), colonic mucosal injury and inflammation were significantly exacerbated in DSS-treated PILRα-deficient mice compared with wild-type (WT) mice. Flow cytometric analysis revealed that neutrophil and macrophage cell numbers were higher in the colons of DSS-treated PILRα-deficient mice than in those of WT mice. Blockade of CXCR2 expressed on neutrophils using a CXCR2 inhibitor decreased the severity of colitis observed in PILRα-deficient mice. These results suggest that PILRα negatively regulates inflammatory colitis by regulating the infiltration of inflammatory cells such as neutrophils and macrophages.

  2. Hydrologic Drought Decision Support System (HyDroDSS)

    Science.gov (United States)

    Granato, Gregory E.

    2014-01-01

    The hydrologic drought decision support system (HyDroDSS) was developed by the U.S. Geological Survey (USGS) in cooperation with the Rhode Island Water Resources Board (RIWRB) for use in the analysis of hydrologic variables that may indicate the risk for streamflows to be below user-defined flow targets at a designated site of interest, which is defined herein as data-collection site on a stream that may be adversely affected by pumping. Hydrologic drought is defined for this study as a period of lower than normal streamflows caused by precipitation deficits and (or) water withdrawals. The HyDroDSS is designed to provide water managers with risk-based information for balancing water-supply needs and aquatic-habitat protection goals to mitigate potential effects of hydrologic drought. This report describes the theory and methods for retrospective streamflow-depletion analysis, rank correlation analysis, and drought-projection analysis. All three methods are designed to inform decisions made by drought steering committees and decisionmakers on the basis of quantitative risk assessment. All three methods use estimates of unaltered streamflow, which is the measured or modeled flow without major withdrawals or discharges, to approximate a natural low-flow regime. Retrospective streamflow-depletion analysis can be used by water-resource managers to evaluate relations between withdrawal plans and the potential effects of withdrawal plans on streams at one or more sites of interest in an area. Retrospective streamflow-depletion analysis indicates the historical risk of being below user-defined flow targets if different pumping plans were implemented for the period of record. Retrospective streamflow-depletion analysis also indicates the risk for creating hydrologic drought conditions caused by use of a pumping plan. Retrospective streamflow-depletion analysis is done by calculating the net streamflow depletions from withdrawals and discharges and applying these depletions

  3. Decision Support Systems (DSS in Construction Tendering Processes

    Directory of Open Access Journals (Sweden)

    Rosmayati Mohemad

    2010-03-01

    Full Text Available The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support System (DSS components is included in the next section. Furthermore, prior researches on implementation of DSS approaches in tendering processes are discussed in details. Current issues arise from both of paper-based and Web-based tendering processes are outlined. Finally, conclusion is included at the end of this paper.

  4. Data Warehouse Architecture for DSS Applciations

    Directory of Open Access Journals (Sweden)

    V. J. Anand

    1996-11-01

    Full Text Available A data warehouse facilitates the integration of disparate operational databases in an enterprise into a single store. The warehouse then provides knowledge workers with easy access to historical, summarized and other forms of aggregated data. A major flaw in present warehouse architectures is the de-coupling of the warehouse database from its underlying operational databases. This creates two problems: the difficulty in updating the warehouse and the inability to provide users with a drill-down feature from warehouse to current data. We propose an architecture that is based on a federated database system extended to incorporate a materialized warehouse. A federated database provides the basic mechanism to tightly couple heterogeneous databases, which in this case are the operational and warehouse databases. The warehouse database is a special component in the federation, made up of historical data, external data and materialized views of the operational data. This approach enables users to access historical and current data when required, and provides a method of maintaining the warehouse as an integrated view of the underlying operational data sources.

  5. The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies

    Science.gov (United States)

    Robertis, Mariangela De; Massi, Emanuela; Poeta, Maria Luana; Carotti, Simone; Morini, Sergio; Cecchetelli, Loredana; Signori, Emanuela; Fazio, Vito Michele

    2011-01-01

    Colorectal cancer (CRC) is a major health problem in industrialized countries. Although inflammation-linked carcinogenesis is a well accepted concept and is often observed within the gastrointestinal tract, the underlying mechanisms remain to be elucidated. Inflammation can indeed provide initiating and promoting stimuli and mediators, generating a tumour-prone microenvironment. Many murine models of sporadic and inflammation-related colon carcinogenesis have been developed in the last decade, including chemically induced CRC models, genetically engineered mouse models, and xenoplants. Among the chemically induced CRC models, the combination of a single hit of azoxymethane (AOM) with 1 week exposure to the inflammatory agent dextran sodium sulphate (DSS) in rodents has proven to dramatically shorten the latency time for induction of CRC and to rapidly recapitulate the aberrant crypt foci–adenoma–carcinoma sequence that occurs in human CRC. Because of its high reproducibility and potency, as well as the simple and affordable mode of application, the AOM/DSS has become an outstanding model for studying colon carcinogenesis and a powerful platform for chemopreventive intervention studies. In this article we highlight the histopathological and molecular features and describe the principal genetic and epigenetic alterations and inflammatory pathways involved in carcinogenesis in AOM/DSS–treated mice; we also present a general overview of recent experimental applications and preclinical testing of novel therapeutics in the AOM/DSS model. PMID:21483655

  6. Artificial Intelligence (AI), Operations Research (OR), and Decision Support Systems (DSS): A conceptual framework

    Science.gov (United States)

    Parnell, Gregory S.; Rowell, William F.; Valusek, John R.

    1987-01-01

    In recent years there has been increasing interest in applying the computer based problem solving techniques of Artificial Intelligence (AI), Operations Research (OR), and Decision Support Systems (DSS) to analyze extremely complex problems. A conceptual framework is developed for successfully integrating these three techniques. First, the fields of AI, OR, and DSS are defined and the relationships among the three fields are explored. Next, a comprehensive adaptive design methodology for AI and OR modeling within the context of a DSS is described. These observations are made: (1) the solution of extremely complex knowledge problems with ill-defined, changing requirements can benefit greatly from the use of the adaptive design process, (2) the field of DSS provides the focus on the decision making process essential for tailoring solutions to these complex problems, (3) the characteristics of AI, OR, and DSS tools appears to be converging rapidly, and (4) there is a growing need for an interdisciplinary AI/OR/DSS education.

  7. Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.

    Science.gov (United States)

    Arai, Katsuhito; Mizobuchi, Yu; Tokuji, Yoshihiko; Aida, Kazuhiko; Yamashita, Shinji; Ohnishi, Masao; Kinoshita, Mikio

    2015-01-01

    The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.

  8. Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.

    Science.gov (United States)

    Liu, Bo; Lin, Qinlu; Yang, Tao; Zeng, Linna; Shi, Limin; Chen, Yaya; Luo, Feijun

    2015-11-01

    Ulcerative colitis is a major inflammatory bowel disease (IBD), characterized by inflammation within the gastrointestinal tract through chronic or relapsing immune system activation. The aim of this study is to investigate the potential protective effect of oat β-glucan (βG) against colitis induced by DSS in mice. Eighty mice were randomly divided into the control group (no DSS, no βG), DSS group (DSS only), DSS + L-βG group (DSS plus 500 mg per kg βG), and DSS + H-βG group (DSS plus 1000 mg per kg βG). Compared with the DSS group, administration of βG significantly reduced clinical symptoms with less weight loss, diarrhea and shortening of the colon, the severity of colitis was significantly inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in colon. Moreover, treatment with βG not only decreased myeloperoxidase activity (MPO), and nitric oxide (NO) and malondialdehyde (MDA) levels, but also inhibited mRNA and protein expression of pro-inflammatory factors such as TNF-α, IL-1β, IL-6 and iNOS. This suggests that oat βG in diet might exhibit an anti-inflammatory function against colitis through inhibition of expression of pro-inflammatory factors.

  9. Regulation of Rad51-Mediated Homologous Recombination by BRCA2, DSS1 and RAD52

    DEFF Research Database (Denmark)

    Rants, Louise Olthaver Juhl

    in governing the activity of Rad51 and to learn how other recombination-associated proteins such as DSS1 and RAD52 contribute to its regulation. We use the yeast-like fungus Ustilago maydis and the avian DT40 cell line as experimental systems since both have a well-conserved BRCA2-based recombinational repair...... system that resembles the one seen in human. In U. maydis, we show that Brh2, the BRCA2 homologue, and Dss1 colocalize at DNA damage-induced foci, with Dss1 exhibiting a dynamic association with Brh2 foci. Dss1 focus formation is dependent on interaction with full-length Brh2, and the Dss1-Brh2...... interaction is required for resistance to DNA damage. In avian DT40 cells, we show that endogenously tagged DSS1 redistributes into subnuclear foci in response to DNA damaging agents. However, DSS1 rarely colocalizes with BRCA2. Our data also indicate that both U. maydis Dss1 and avian DSS1 are involved...

  10. Gamma ray sources observation with the ARGO-YBJ detector

    Energy Technology Data Exchange (ETDEWEB)

    Vernetto, S., E-mail: vernetto@to.infn.it [IFSI-INAF, Corso Fiume 4, 10133 Torino (Italy)

    2012-11-11

    Since November 2007 the air shower detector ARGO-YBJ is continuously monitoring the gamma ray sky in the declination band from -10 Degree-Sign to +70 Degree-Sign at energies E>0.5TeV. In this work we present the results of our observations of galactic and extragalactic sources during more than 3 years, focusing our attention on the Crab Nebula, the blazar Mrk 421 and the galactic extended source MGRO J1908+06, probably associated to the Fermi pulsar PSR J1907+0602.

  11. Gamma ray sources observed with ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Vernetto, S., E-mail: vernetto@to.infn.it [INAF, Osservatorio Astrofisico di Torino (Italy); INFN, Sezione di Torino (Italy)

    2013-06-15

    The air shower detector ARGO-YBJ is continuously monitoring the gamma ray sky in the declination band from −10° to +70° at energies E>0.5TeV. After ∼4 years of operation, the integrated sensitivity reached the level of ∼28% the Crab Nebula flux. In this work we present a summary of our observations concerning the Crab Nebula, the Cygnus region, the galactic source MGRO J1908+06, and the blazars Mrk421 and Mrk501.

  12. Latest results from the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, Giuseppe

    2015-01-01

    The ARGO-YBJ experiment has been in stable data taking for 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). With a duty-cycle greater than 86\\% the detector collected about 5$\\times $10$^{11}$ events in a wide energy range, from few hundreds GeV up to about 10 PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this paper we summarize the latest results in cosmic ray physics and in gamma-ray astronomy.

  13. Data assimilation of Argo profiles in a northwestern Pacific model

    Science.gov (United States)

    Wang, Zhaoyi; Storto, Andrea; Pinardi, Nadia; Liu, Guimei; Wang, Hui

    2017-01-01

    Based on a novel estimation of background-error covariances for assimilating Argo profiles, an oceanographic three-dimensional variational (3DVAR) data assimilation scheme was developed for the northwestern Pacific Ocean model (NwPM) for potential use in operational predictions and maritime safety applications. Temperature and salinity data extracted from Argo profiles from January to December 2010 were assimilated into the NwPM. The results show that the average daily temperature (salinity) root mean square error (RMSE) decreased from 0.99 °C (0.10 psu) to 0.62 °C (0.07 psu) in assimilation experiments throughout the northwestern Pacific, which represents a 37.2 % (27.6 %) reduction in the error. The temperature (salinity) RMSE decreased by ˜ 0.60 °C ( ˜ 0.05 psu) for the upper 900 m (1000 m). Sea level, temperature and salinity were in better agreement with in situ and satellite datasets after data assimilation than before. In addition, a 1-month experiment with daily analysis cycles and 5-day forecasts explored the performance of the system in an operational configuration. The results highlighted the positive impact of the 3DVAR initialization at all forecast ranges compared to the non-assimilative experiment. Therefore, the 3DVAR scheme proposed here, coupled to ROMS, shows a good predictive performance and can be used as an assimilation scheme for operational forecasting.

  14. Application of Argo-derived background diapycnal mixing in HYCOM

    Science.gov (United States)

    Deng, Zengan; Yu, Ting

    2014-09-01

    Internal wave-induced background diapycnal mixing (DM) in the upper 2000 m of the global ocean, which primarily depends on the local inertial frequency, is calculated based on Argo observations using the newly published Thermodynamic Equation of Seawater-2010 (IOC, SCOR and IAPSO, 2010). This spatially dependent background DM agrees well with previous theoretical and observational mixing estimates. More importantly, the DM data are gridded, which renders the data suitable for modeling applications. The implementation of these data in the HYbrid Coordinate Ocean Model (HYCOM) demonstrates the potential for their application in numerical ocean models. Three numerical experiments that are specifically designed with different DM settings reveal that the meridional overturning circulation (MOC), temperature and salinity in the Atlantic change substantially when the constant background DM is replaced with Argo-derived mixing. Tropical and high-latitude regions that are considered important for global climate are identified as the areas that are most sensitive to the magnitude of the background DM. Compared with constant background DM, the enhanced mid-latitude DM most likely contributes substantially to the MOC transport. Thus, although room remains for improvement, the spatially varying DM derived in the present study may facilitate global circulation and climate modeling.

  15. The Status of the ARGO Experiment at YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Aielli, G. [Dipartimento di Fisica dell' Universita ' Tor Vergata' di Roma and INFN Sezione di Roma2 (Italy); Bacci, C. [Dipartimento di Fisica dell' Universita ' Roma Tre' di Roma and INFN Sezione di Roma3 (Italy); Bartoli, B. [Dipartimento di Fisica dell' Universita di Napoli and INFN Sezione di Napoli (Italy); Bernardini, P. [Dipartimento di Fisica dell' Universita di Lecce and INFN Sezione di Lecce (Italy); Bi, X.J. [Key Laboratory of Particle Astrophyics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing (China); Bleve, C. [Dipartimento di Fisica dell' Universita di Lecce and INFN Sezione di Lecce (Italy); Bussino, S. [Dipartimento di Fisica dell' Universita ' Roma Tre' di Roma and INFN Sezione di Roma3 (Italy); Calabrese Melcarne, A.K. [Dipartimento di Fisica dell' Universita di Lecce and INFN Sezione di Lecce (Italy); Camarri, P. [Dipartimento di Fisica dell' Universita ' Tor Vergata' di Roma and INFN Sezione di Roma2 (Italy); Campana, D. [Dipartimento di Fisica dell' Universita di Napoli and INFN Sezione di Napoli (Italy); Cao, Z. [Key Laboratory of Particle Astrophyics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing (China); Cardarelli, R. [Dipartimento di Fisica dell' Universita ' Tor Vergata' di Roma and INFN Sezione di Roma2 (Italy); Catalanotti, S.; Cavaliere, S. [Dipartimento di Fisica dell' Universita di Napoli and INFN Sezione di Napoli (Italy); Celio, P. [Dipartimento di Fisica dell' Universita ' Roma Tre' di Roma and INFN Sezione di Roma3 (Italy); Chen, S.Z.; Cheng, N. [Key Laboratory of Particle Astrophyics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing (China); Creti, P. [Dipartimento di Fisica dell' Universita di Lecce and INFN Sezione di Lecce(Italy); Cui, S.W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China)] (and others)

    2007-04-15

    The ARGO-YBJ experiment, located at Yangbajing, Tibet, China, performed by a wide Sino-Italian collaboration, is designed to study cosmic rays, sub-TeV gamma ray sources and GeV Gamma Ray Burst (GRB) emission in the northern hemisphere, by means of detecting small size EAS (Extensive Air Shower) using a full coverage RPC (Resistive Plate Chamber) carpet. The central carpet of the detector is installed and put into operation to date, with 1900m{sup 2} of the carpet already operating since December 2004. With a trigger multiplicity of {>=}60 hits, corresponding to a primary mode energy of 2 TeV, the angular resolution of EAS measurements is < 1{sup o} for showers with more than 500 recorded hits. We report the preliminary results of data taking performed during 2005: the all-sky survey for gamma ray sources and the search for GRBs, as well as the cosmic ray spectrum up to about 100 TeV. The Forbush decrease of the cosmic ray flux during January, 2005 is observed using the ARGO data.

  16. ARGO-YBJ: Physics results and detector stabilization

    Energy Technology Data Exchange (ETDEWEB)

    Camarri, P., E-mail: camarri@roma2.infn.it [Università di Roma “Tor Vergata”, Dipartimento di Fisica, Via della Ricerca Scientifica 1, Roma (Italy); INFN, Sezione di Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy)

    2013-08-01

    The ARGO-YBJ experiment at 4300 m above sea level on the Tibet plateau is a full-coverage array of Resistive Plate Chambers (RPCs) operated in streamer mode, covering a surface of 74×78 m{sup 2} surrounded by a guard ring. It was designed to detect extensive air showers generated by primary cosmic rays in the energy range from a few hundred GeV up to about 1 PeV. It has been running uninterruptedly with its complete layout since October 2007, providing results in γ-ray astrophysics and cosmic-ray physics. Some of the main results obtained by ARGO-YBJ in the study of TeV γ rays from Supernova Remnants and from Active Galactic Nuclei and in the study of the medium-scale cosmic-ray anisotropy will be described. We also discuss the results of a test which proves the feasibility of the control procedure devised to stabilize the response of the detector.

  17. How essential are Argo observations to constrain a global ocean data assimilation system?

    Science.gov (United States)

    Turpin, V.; Remy, E.; Le Traon, P. Y.

    2016-02-01

    Observing system experiments (OSEs) are carried out over a 1-year period to quantify the impact of Argo observations on the Mercator Ocean 0.25° global ocean analysis and forecasting system. The reference simulation assimilates sea surface temperature (SST), SSALTO/DUACS (Segment Sol multi-missions dALTimetrie, d'orbitographie et de localisation précise/Data unification and Altimeter combination system) altimeter data and Argo and other in situ observations from the Coriolis data center. Two other simulations are carried out where all Argo and half of the Argo data are withheld. Assimilating Argo observations has a significant impact on analyzed and forecast temperature and salinity fields at different depths. Without Argo data assimilation, large errors occur in analyzed fields as estimated from the differences when compared with in situ observations. For example, in the 0-300 m layer RMS (root mean square) differences between analyzed fields and observations reach 0.25 psu and 1.25 °C in the western boundary currents and 0.1 psu and 0.75 °C in the open ocean. The impact of the Argo data in reducing observation-model forecast differences is also significant from the surface down to a depth of 2000 m. Differences between in situ observations and forecast fields are thus reduced by 20 % in the upper layers and by up to 40 % at a depth of 2000 m when Argo data are assimilated. At depth, the most impacted regions in the global ocean are the Mediterranean outflow, the Gulf Stream region and the Labrador Sea. A significant degradation can be observed when only half of the data are assimilated. Therefore, Argo observations matter to constrain the model solution, even for an eddy-permitting model configuration. The impact of the Argo floats' data assimilation on other model variables is briefly assessed: the improvement of the fit to Argo profiles do not lead globally to unphysical corrections on the sea surface temperature and sea surface height. The main conclusion

  18. TeV gamma-ray survey of the northern sky using the ARGO-YBJ detector

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S. [Dipartimento di Fisica dell' Università di Napoli " Federico II," Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A.; De Mitri, I. [Dipartimento Matematica e Fisica " Ennio De Giorgi," Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Bolognino, I. [Dipartimento di Fisica dell' Università di Pavia, via Bassi 6, I-27100 Pavia (Italy); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Calabrese Melcarne, A. K. [Istituto Nazionale di Fisica Nucleare - CNAF, Viale Berti-Pichat 6/2, I-40127 Bologna (Italy); Camarri, P. [Dipartimento di Fisica dell' Università di Roma " Tor Vergata," via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z., E-mail: chensz@ihep.ac.cn [Yunnan University, 2 North Cuihu Rd., 650091 Kunming, Yunnan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2013-12-10

    The Astrophysical Radiation with Ground-based Observatory at Yang Ba Jing (ARGO-YBJ) detector is an extensive air shower array that has been used to monitor the northern γ-ray sky at energies above 0.3 TeV from 2007 November to 2013 January. In this paper, we present the results of a sky survey in the declination band from –10° to 70°, using data recorded over the past five years. With an integrated sensitivity ranging from 0.24 to ∼1 Crab units depending on the declination, six sources have been detected with a statistical significance greater than five standard deviations. Several excesses are also reported as potential γ-ray emitters. The features of each source are presented and discussed. Additionally, 95% confidence level upper limits of the flux from the investigated sky region are shown. Specific upper limits for 663 GeV γ-ray active galactic nuclei inside the ARGO-YBJ field of view are reported. The effect of the absorption of γ-rays due to the interaction with extragalactic background light is estimated.

  19. WAR DSS: A DECISION SUPPORT SYSTEM FOR ENVIRONMENTALLY CONSCIOUS CHEMICAL PROCESS DESIGN

    Science.gov (United States)

    The second generation of the Waste Reduction (WAR) Algorithm is constructed as a decision support system (DSS) in the design of chemical manufacturing facilities. The WAR DSS is a software tool that can help reduce the potential environmental impacts (PEIs) of industrial chemical...

  20. Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis

    DEFF Research Database (Denmark)

    Kojic, Milorad; Zhou, Qingwen; Lisby, Michael;

    2005-01-01

    Brh2, the BRCA2 homolog in Ustilago maydis, functions in recombinational repair of DNA damage by regulating Rad51 and is, in turn, regulated by Dss1. Dss1 is not required for Brh2 stability in vivo, nor for Brh2 to associate with Rad51, but is required for formation of green fluorescent protein...

  1. [Water quality forewarning model in the framework of water pollution forewarning DSS].

    Science.gov (United States)

    Guo, Yu; Jia, Hai-Feng

    2010-12-01

    In order to deal with the water pollution accident and take emergency measures effectively, water pollution forewarning decision support systems (DSS) is important to be established and water quality forewarning model is one of the hard points of DSS. Miyun Reservoir is the most important surface water sources of Beijing. Baihe River, which is the upstream river of Miyun Reservoir, is selected as the case study in this paper. The three-layer frame of the water pollution forewarning DSS is proposed with the core of mathematical model; then model development and parameterization are studied. Finally, a typical accident of NaCN pollution is taken for instance; the scenario of the accident is simulated and analyzed by DSS. The case study shows that the DSS could precisely analyze and forecast the pollution development trend, and simulate the different impact of emergency proposal. The result could support the primary decision of the emergency proposal to meet the functional requirement of the system.

  2. Histopathological and morphometric changes induced by a dextran sodium sulfate (DSS) model in broilers.

    Science.gov (United States)

    Menconi, A; Hernandez-Velasco, X; Vicuña, E A; Kuttappan, V A; Faulkner, O B; Tellez, G; Hargis, B M; Bielke, L R

    2015-05-01

    Oral administration of dextran sodium sulfate (DSS) is commonly used as an inducer of enteric inflammation in rodents. However, there is a dearth of knowledge regarding appropriate dosage, timing, or ageresponses in broilers for this potential inducer of inflammation without necrosis. Two experiments were conducted in day-of-hatch chicks to analyze clinical parameters and enteric histological changes induced by DSS when administered via drinking water ( DW: ). In both experiments, birds were distributed into nontreated control or varying concentrations of DSS in DW. For both experiments, only 0.75% DSS in DW was histologically evaluated. In Experiment 1, chicks received DSS from day 3 to 11, and at 3, 6, and 8 d of treatment, chicks were weighed, and sections of the duodenum, ileum, and ceca were formalin fixed. The addition of 0.75% DSS caused depression, anemia, and watery bloody diarrhea, plus significantly (P DSS administration (P DSS from days 10 to 16 and were sampled at 3 and 6 d of treatment. Similar changes were found in ceca of treated birds. There was no significant change in the duodenal villus height and goblet cell density by 6 d of treatment, suggesting that 6 d of 0.75% DSS in DW was not sufficient for the reproduction of duodenal symptoms in these older birds. However, there was a significant decrease in ilealvillus height and decreased ileal epithelial cell height at 3 and 6 d of treatment, as well as a significant decrease in BW compared to the control group. These findings indicate that DW administration of 0.75% DSS caused generalized mild and non-necrotic enteritis in broilers and that this compound may be useful for enteric inflammation modeling in poultry.

  3. Decision Support Systems (DSS) in Construction Tendering Processes

    CERN Document Server

    Mohemad, Rosmayati; Othman, Zulaiha Ali; Noor, Noor Maizura Mohamad

    2010-01-01

    The successful execution of a construction project is heavily impacted by making the right decision during tendering processes. Managing tender procedures is very complex and uncertain involving coordination of many tasks and individuals with different priorities and objectives. Bias and inconsistent decision are inevitable if the decision-making process is totally depends on intuition, subjective judgement or emotion. In making transparent decision and healthy competition tendering, there exists a need for flexible guidance tool for decision support. Aim of this paper is to give a review on current practices of Decision Support Systems (DSS) technology in construction tendering processes. Current practices of general tendering processes as applied to the most countries in different regions such as United States, Europe, Middle East and Asia are comprehensively discussed. Applications of Web-based tendering processes is also summarised in terms of its properties. Besides that, a summary of Decision Support Sy...

  4. Quality Control of ARGO Data Based on Climatological T-S Models

    Institute of Scientific and Technical Information of China (English)

    纪风颖; 林绍花

    2004-01-01

    By implementing the ARGO program, a large number of T-S profiles can be observed in the world ocean. However, it is very difficult to examine changes of the sensitivity of the sensors equipped at the ARGO floats, because it is difficult to understand their condition in the sea and the reliability of the data. Quality control must be done in order to avoid the wrong conclusion deduced from the wrong data.One of the realistic methods for quality control of the ARGO data is the comparison with the local climatology. High quality climatological T-S models in northwest Pacific have been built based on the Nansen bottle data and CTD data for the quality control in NMDIS. The models are used to check the ARGO data in this area and have got good result.

  5. Accurate estimation of influenza epidemics using Google search data via ARGO.

    Science.gov (United States)

    Yang, Shihao; Santillana, Mauricio; Kou, S C

    2015-11-24

    Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistical foundation, ARGO outperforms all previously available Google-search-based tracking models, including the latest version of Google Flu Trends, even though it uses only low-quality search data as input from publicly available Google Trends and Google Correlate websites. ARGO not only incorporates the seasonality in influenza epidemics but also captures changes in people's online search behavior over time. ARGO is also flexible, self-correcting, robust, and scalable, making it a potentially powerful tool that can be used for real-time tracking of other social events at multiple temporal and spatial resolutions.

  6. Kauglabor ehk Üle mere õppimine / Argo Rosin ; intervjueerinud Raivo Juurak

    Index Scriptorium Estoniae

    Rosin, Argo, 1972-

    2011-01-01

    Intervjuu TTÜ elektriajamite ja jõuelektroonika instituudi teaduri Argo Rosinaga kauglaborist, kus Kuressaare kolledži üliõpilased käivitavad TTÜ energeetikamajas üles pandud elektrilisi katseseadmeid Saaremaalt lahkumata

  7. 76 FR 63676 - Final Division of Safety Systems Interim Staff Guidance DSS-ISG-2010-01: Staff Guidance Regarding...

    Science.gov (United States)

    2011-10-13

    ... COMMISSION Final Division of Safety Systems Interim Staff Guidance DSS-ISG- 2010-01: Staff Guidance Regarding... final Division of Safety Systems Interim Staff Guidance, (DSS-ISG) DSS- ISG-2010-01, ``Staff Guidance... guidance to the NRC staff reviewer to address the increased complexity of recent spent fuel pool...

  8. Multiple shell shower fronts in EAS with ARGO-YBJ

    Directory of Open Access Journals (Sweden)

    Marsella G.

    2015-01-01

    Full Text Available The ARGO-YBJ experiment is an Extensive Air Shower array that has been operated at the high altitude Yangbajing Cosmic Ray Laboratory (Tibet, P.R. China 4300 m a.s.l. in its final configuration since December 2007 until February 2013. The detector consists of a dense layer of Resistive Plate Counters (RPCs covering an area of about 11000 m2. It has been designed to measure the temporal and spatial structure of Extensive Air Showers (EAS with high space-time resolution. The detector gives a quite highly detailed picture of shower footprints at ground. It is perfectly suitable to understand the EAS morphology. These detector characteristics have been used for seeking particles of large rest mass produced in cosmic rays by measuring the Multiple Shell Shower Fronts relative delays. The technique and preliminary results will be illustrated in the present work.

  9. A novel roseobacter phage possesses features of podoviruses, siphoviruses, prophages and gene transfer agents

    Science.gov (United States)

    Zhan, Yuanchao; Huang, Sijun; Voget, Sonja; Simon, Meinhard; Chen, Feng

    2016-07-01

    Bacteria in the Roseobacter lineage have been studied extensively due to their significant biogeochemical roles in the marine ecosystem. However, our knowledge on bacteriophage which infects the Roseobacter clade is still very limited. Here, we report a new bacteriophage, phage DSS3Φ8, which infects marine roseobacter Ruegeria pomeroyi DSS-3. DSS3Φ8 is a lytic siphovirus. Genomic analysis showed that DSS3Φ8 is most closely related to a group of siphoviruses, CbK-like phages, which infect freshwater bacterium Caulobacter crescentus. DSS3Φ8 contains a smaller capsid and has a reduced genome size (146 kb) compared to the CbK-like phages (205–279 kb). DSS3Φ8 contains the DNA polymerase gene which is closely related to T7-like podoviruses. DSS3Φ8 also contains the integrase and repressor genes, indicating its potential to involve in lysogenic cycle. In addition, four GTA (gene transfer agent) genes were identified in the DSS3Φ8 genome. Genomic analysis suggests that DSS3Φ8 is a highly mosaic phage that inherits the genetic features from siphoviruses, podoviruses, prophages and GTAs. This is the first report of CbK-like phages infecting marine bacteria. We believe phage isolation is still a powerful tool that can lead to discovery of new phages and help interpret the overwhelming unknown sequences in the viral metagenomics.

  10. Consistency of Aquarius sea surface salinity with Argo products on various spatial and temporal scales

    Science.gov (United States)

    Lee, Tong

    2016-04-01

    Understanding the accuracies of satellite-derived sea surface salinity measurements in depicting temporal changes and their dependence on spatiotemporal scales is important to applications, capability assessment, and future satellite mission design. This study quantifies the consistency between Aquarius Version 4 monthly gridded sea surface salinity (SSS) with two Argo-based monthly gridded near-surface salinity products for describing temporal changes on 1° × 1°, 3° × 3°, and 10° × 10° scales. Globally averaged standard deviation values for Aquarius-Argo salinity differences on these three spatial scales are 0.16, 0.14, and 0.09 practical salinity unit (psu), compared to those between the two Argo products of 0.10, 0.09, and 0.04 psu. The consistency between Aquarius and Argo is similar to that between the two Argo products in the tropics for seasonal signals, and in the tropics and midlatitudes for nonseasonal signals. Therefore, the uncertainties of Argo products for various scales need to be considered in evaluating satellite SSS. Innovative satellite technologies are needed to improve high-latitude satellite SSS measurements.

  11. CXCR2 knockout mice are protected against DSS-colitis-induced acute kidney injury and inflammation.

    Science.gov (United States)

    Ranganathan, Punithavathi; Jayakumar, Calpurnia; Manicassamy, Santhakumar; Ramesh, Ganesan

    2013-11-15

    Organ cross talk exists in many diseases of the human and animal models of human diseases. A recent study demonstrated that inflammatory mediators can cause acute kidney injury and neutrophil infiltration in a mouse model of dextran sodium sulfate (DSS)-colitis. However, the chemokines and their receptors that may mediate distant organ effects in colitis are unknown. We hypothesized that keratinocyte chemoattractant (KC)/IL-8 receptor chemokine (C-X-C motif) ligand 2 (CXCL2) mediates DSS-colitis-induced acute kidney injury. Consistent with our hypothesis, wild-type (WT) mice developed severe colitis with DSS treatment, which was associated with inflammatory cytokine and chemokine expression and neutrophil infiltration in the colon. DSS-colitis in WT was accompanied by acute kidney injury and enhanced expression of inflammatory cytokines in the kidney. However, CXCR2 knockout mice were protected against DSS-colitis as well as acute kidney injury. Moreover, the expression of cytokines and chemokines and neutrophil infiltration was blunted in CXCR2 knockout mice in the colon and kidney. Administration of recombinant KC exacerbated DSS-colitis-induced acute kidney injury. Our results suggest that KC/IL-8 and its receptor CXCR2 are critical and major mediators of organ cross talk in DSS colitis and neutralization of CXCR2 will help to reduce the incidence of acute kidney injury due to ulcerative colitis and Crohn's disease in humans.

  12. Driving Backwards Using a Semi-Autonomous Smart Wheelchair System (DSS: A Clinical Evaluation

    Directory of Open Access Journals (Sweden)

    Vinod Sharma

    2012-01-01

    Full Text Available Some wheelchair users have difficulty looking backward when backing up in confined spaces due to limited neck range of motion or low vision, which can lead to collisions which may result in personal injury or property damage. The Drive Safe System (DSS was evaluated in a controlled laboratory setting with blindfolded able-bodied individuals on various backward driving tasks. Performance with the DSS was compared with a standard white cane used for navigation assistance by people with visual impairment. Results indicate that the DSS significantly reduced the number of collisions compared to using a cane (p = 0.0001 alone. There was no difference in task completion time when participants were using the cane or the DSS (p = 0.915. Users rated the DSS favourably as they experience less total workload (p = 0.026, less physical demand (p = 0.006, felt less frustrated (p = 0.002 and put less effort (p = 0.007 to achieve better performance when using the DSS, compared to using a cane. These findings suggest that the DSS can be a viable powered mobility solution for wheelchair users with visual impairments.

  13. Exploring the development of a decision support system (DSS) to prioritize engineered nanoparticles for risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Marvin, Hans J. P., E-mail: hans.marvin@wur.nl; Bouwmeester, Hans [RIKILT, Wageningen UR (Netherlands); Bakker, Martine [National Institute for Public Health and the Environment, RIVM (Netherlands); Kroese, E. Dinant [TNO Innovation for Life, Earth, Environmental and Life Sciences (Netherlands); Meent, Dik van de [Radboud University Nijmegen, Institute for Water and Wetland Research, Department of Environmental Science (Netherlands); Bourgeois, Francois [National Institute for Public Health and the Environment, RIVM (Netherlands); Lokers, Rob [Alterra, Wageningen UR (Netherlands); Ham, Henk van der [RIKILT, Wageningen UR (Netherlands); Verhelst, Lieke [Alterra, Wageningen UR (Netherlands)

    2013-08-15

    Engineered nanoparticles (ENPs) have gained huge commercial interest because of their unique and size-related physicochemical properties. The diversity and complexity of ENPs is increasing with the introduction of next generation nanoparticles. The current approaches are not able to assess the safety of all types and applications of ENPs. Therefore, we are developing a decision support system (DSS) that helps to identify those ENPs and applications that should get priority in the risk assessment. This DSS smartly uses existing knowledge in publicly available databases. With the aid of vocabularies, knowledge rules and logic reasoning new knowledge will be derived. In this paper, the procedure for a DSS is described. Since this system is open by design, others can re-use and extend the DSS content, and newly developed DSS tools can be easily accommodated, which will make the DSS more effective over the years. Data of newly emerging studies will be used for the validation of the DSS. The results will benefit regulating authorities and scientists focussing on the development of inherently safe ENPs.

  14. On the nature of the Madagascar dipoles: An analysis from Argo profiling floats and altimetry measurements

    Science.gov (United States)

    Aguiar-González, Borja; Ponsoni, Leandro; Ridderinkhof, Herman; de Ruijter, Will P. M.; Maas, Leo R. M.

    2016-04-01

    The South East Madagascar Current (SEMC) flows poleward along the eastern coast of Madagascar as a western boundary current which further south provides some of the source waters of the Agulhas Current, either directly or in the form of eddies. We investigate the region of dipole formation south of Madagascar combining vertical T/S profiles from Argo floats, altimetry measurements and an existing eddy detection algorithm. Results from our analysis show that the dipole consists of an anticyclonic intrathermocline eddy (ITE) formed on its southern flank and a cyclonic ITE formed on its northern flank. Both lobes of the dipole exhibit similar T/S properties throughout the water column, although vertically shifted within the thermocline depending on its nature: upward in a cyclonic ITE and downward in an anticyclonic ITE. A subsurface salinity maximum of about 35.5 psu characterizes the upper layers with Subtropical Surface Water (STSW). At intermediate levels, a well defined path of South Indian Central Water (SICW) extends throughout the water column up to reach a minimum in salinity of 34.5 psu, corresponding to Antarctic Intermediate Water (AAIW). Below, at deep layers, the North Atlantic Deep Water (NADW) is found. The intrathermocline nature of the Madagascar dipoles has not been previously reported and represents an important feature to be considered when assessing the heat and salt fluxes driven by eddy movement and contributing to the Agulhas Current. Unlike surface eddies, intrathermocline eddies strongly influence the intermediate/deeper layers in the oceans and, hence, may have a larger contribution in the spreading rates and pathways of water masses. Because the intrathermocline nature of eddies is invisible to altimetry measurements, these results stress the importance of combining altimetry with historical records of Argo profiles which uncover eddy dynamics below the sea surface. Lastly, we further investigate from altimetry the area of dipole formation

  15. ARGO-YBJ:丰富多彩的宇宙线观测%ARGO-YBJ: Fruitful Cosmic Ray Observations

    Institute of Scientific and Technical Information of China (English)

    曹臻

    2012-01-01

    Being smoothly operated for 5 years, the ARGO-YBJ experiment collected 0.4 trillion cosmic ray event samples. Many scientific goals have been achieved based on the very important data base. Here in this article, we summarize all major contributions to cosmic ray related researches, including conventional measurements such as cosmic ray energy spectrum, composition and anisotropy. The researches also cover many non-traditional topics such as the monitoring of solar activity using Galactic cosmic rays, forecasting large geomagnetic storms induced by huge flares of the sun, exploring the correlation between thunderstorms and extensives air shower of cosmic rays and so forth. With the progresses of the future experiment LHAASO, all researches reported in this paper will be greatly enhanced using the most sensitive new generation apparatus. Breakthrough may be expected in some of the topics.

  16. Overexpression of ARGOS Genes Modifies Plant Sensitivity to Ethylene, Leading to Improved Drought Tolerance in Both Arabidopsis and Maize.

    Science.gov (United States)

    Shi, Jinrui; Habben, Jeffrey E; Archibald, Rayeann L; Drummond, Bruce J; Chamberlin, Mark A; Williams, Robert W; Lafitte, H Renee; Weers, Ben P

    2015-09-01

    Lack of sufficient water is a major limiting factor to crop production worldwide, and the development of drought-tolerant germplasm is needed to improve crop productivity. The phytohormone ethylene modulates plant growth and development as well as plant response to abiotic stress. Recent research has shown that modifying ethylene biosynthesis and signaling can enhance plant drought tolerance. Here, we report novel negative regulators of ethylene signal transduction in Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). These regulators are encoded by the ARGOS gene family. In Arabidopsis, overexpression of maize ARGOS1 (ZmARGOS1), ZmARGOS8, Arabidopsis ARGOS homolog ORGAN SIZE RELATED1 (AtOSR1), and AtOSR2 reduced plant sensitivity to ethylene, leading to enhanced drought tolerance. RNA profiling and genetic analysis suggested that the ZmARGOS1 transgene acts between an ethylene receptor and CONSTITUTIVE TRIPLE RESPONSE1 in the ethylene signaling pathway, affecting ethylene perception or the early stages of ethylene signaling. Overexpressed ZmARGOS1 is localized to the endoplasmic reticulum and Golgi membrane, where the ethylene receptors and the ethylene signaling protein ETHYLENE-INSENSITIVE2 and REVERSION-TO-ETHYLENE SENSITIVITY1 reside. In transgenic maize plants, overexpression of ARGOS genes also reduces ethylene sensitivity. Moreover, field testing showed that UBIQUITIN1:ZmARGOS8 maize events had a greater grain yield than nontransgenic controls under both drought stress and well-watered conditions.

  17. GREENER CHEMICAL PROCESS DESIGN ALTERNATIVES ARE REVEALED USING THE WASTE REDUCTION DECISION SUPPORT SYSTEM (WAR DSS)

    Science.gov (United States)

    The Waste Reduction Decision Support System (WAR DSS) is a Java-based software product providing comprehensive modeling of potential adverse environmental impacts (PEI) predicted to result from newly designed or redesigned chemical manufacturing processes. The purpose of this so...

  18. The UNITE-DSS Modelling System: Risk Simulation and Decision Conferencing

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Barfod, Michael Bruhn

    This presentation introduces the brand new approach of integrating risk simulation and decision conferencing within transport project appraisal (UNITE-DSS model). The modelling approach is divided into various modules respectively as point estimates (cost-benefit analysis), stochastic interval...

  19. CRAB NEBULA: FIVE-YEAR OBSERVATION WITH ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S.; D' Ettorre Piazzoli, B.; Di Girolamo, T. [Dipartimento di Fisica dell' Università di Napoli " Federico II," Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A.; De Mitri, I. [Dipartimento Matematica e Fisica " Ennio De Giorgi," Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Camarri, P. [Dipartimento di Fisica dell' Università di Roma " Tor Vergata," via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R.; Di Sciascio, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016 Hebei (China); Dai, B. Z., E-mail: vernetto@to.infn.it [Yunnan University, 2 North Cuihu Rd., 650091 Kunming, Yunnan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2015-01-10

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ∼3.3 × 10{sup 5} events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I {sub 0} (E/2 TeV){sup –α}, with a flux normalization I {sub 0} = (5.2 ± 0.2) × 10{sup –12} photons cm{sup –2} s{sup –1} TeV{sup –1} and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10{sup –11} photons cm{sup –2} s{sup –1}. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I {sub 0} (E/2 TeV){sup –α} exp (–E/E {sub cut}), the lower limit of the cutoff energy E {sub cut} is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10{sup –2}. A correlated analysis with Fermi-LAT data over ∼4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a ''blind'' search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day{sup –1}, consistent with the average value of 137 ± 10 day{sup –1}.

  20. A DSS for sustainable development and environmental protection of agricultural regions.

    Science.gov (United States)

    Manos, Basil D; Papathanasiou, Jason; Bournaris, Thomas; Voudouris, Kostas

    2010-05-01

    This paper presents a decision support system (DSS) for sustainable development and environmental protection of agricultural regions developed in the framework of the Interreg-Archimed project entitled WaterMap (development and utilization of vulnerability maps for the monitoring and management of groundwater resources in the ARCHIMED areas). Its aim is to optimize the production plan of an agricultural region taking in account the available resources, the environmental parameters, and the vulnerability map of the region. The DSS is based on an optimization multicriteria model. The spatial integration of vulnerability maps in the DSS enables regional authorities to design policies for optimal agricultural development and groundwater protection from the agricultural land uses. The DSS can further be used to simulate different scenarios and policies by the local stakeholders due to changes on different social, economic, and environmental parameters. In this way, they can achieve alternative production plans and agricultural land uses as well as to estimate economic, social, and environmental impacts of different policies. The DSS is computerized and supported by a set of relational databases. The corresponding software has been developed in a Microsoft Windows XP platform, using Microsoft Visual Basic, Microsoft Access, and the LINDO library. For demonstration reasons, the paper includes an application of the DSS in a region of Northern Greece.

  1. Accuracy of ARGOS locations of Pinnipeds at-sea estimated using Fastloc GPS.

    Directory of Open Access Journals (Sweden)

    Daniel P Costa

    Full Text Available BACKGROUND: ARGOS satellite telemetry is one of the most widely used methods to track the movements of free-ranging marine and terrestrial animals and is fundamental to studies of foraging ecology, migratory behavior and habitat-use. ARGOS location estimates do not include complete error estimations, and for many marine organisms, the most commonly acquired locations (Location Class 0, A, B, or Z are provided with no declared error estimate. METHODOLOGY/PRINCIPAL FINDINGS: We compared the accuracy of ARGOS Locations to those obtained using Fastloc GPS from the same electronic tags on five species of pinnipeds: 9 California sea lions (Zalophus californianus, 4 Galapagos sea lions (Zalophus wollebaeki, 6 Cape fur seals (Arctocephalus pusillus pusillus, 3 Australian fur seals (A. p. doriferus and 5 northern elephant seals (Mirounga angustirostris. These species encompass a range of marine habitats (highly pelagic vs coastal, diving behaviors (mean dive durations 2-21 min and range of latitudes (equator to temperate. A total of 7,318 ARGOS positions and 27,046 GPS positions were collected. Of these, 1,105 ARGOS positions were obtained within five minutes of a GPS position and were used for comparison. The 68(th percentile ARGOS location errors as measured in this study were LC-3 0.49 km, LC-2 1.01 km, LC-1 1.20 km, LC-0 4.18 km, LC-A 6.19 km, LC-B 10.28 km. CONCLUSIONS/SIGNIFICANCE: The ARGOS errors measured here are greater than those provided by ARGOS, but within the range of other studies. The error was non-normally distributed with each LC highly right-skewed. Locations of species that make short duration dives and spend extended periods on the surface (sea lions and fur seals had less error than species like elephant seals that spend more time underwater and have shorter surface intervals. Supplemental data (S1 are provided allowing the creation of density distributions that can be used in a variety of filtering algorithms to improve the

  2. The Application of ARGO Data to the Global Ocean Data Assimilation Operational System of NCC

    Institute of Scientific and Technical Information of China (English)

    LIU Yimin; ZHANG Renhe; YIN Yonghong; NIU Tao

    2005-01-01

    In this paper, we have preliminarily studied the application of ARGO (Array for Real-time Geostrophic Oceanography) data to the Global Ocean Data Assimilation System of National Climate Center of China (NCC-GODAS), which mainly contains 4 sub-systems such as data preprocessing, real-time wind stress calculating, variational analysis and interpolating, and ocean dynamic model. For the sake of using ARGO data, the relevant adjustment and improvement have been made at the corresponding aspects in the subsystems.Using the observation data from 1981 to 2003 including the ARGO data of 2001 to July. 2003, we have performed a series of numerical experiments on this system. Comparing with the corresponding results of NCEP, It is illustrated that using ARGO data can improve the results of NCC-GODAS in the region of the Middle Pacific, for instance SST, SSTA (SST anomalies), Nino index, sea sub-surface temperature,etc. Furthermore, it is obtained that NCC-GODAS benefits from ARGO data in the other regions such as Atlantic Ocean, Indian Ocean, and extratropical Pacific Ocean much more than in the tropical Pacific.

  3. Crab Nebula: five-year observation with ARGO-YBJ

    CERN Document Server

    ,

    2015-01-01

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma ray emission from 2007 November to 2013 February. The integrated signal, consisting of $\\sim$3.3 $\\times$ 10$^5$ events,reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I$_0$ (E / 2 TeV)$^{-\\alpha}$, with a flux normalization I$_0$ = (5.2 $\\pm$ 0.2) $\\times$ 10$^{-12}$ photons cm$^{-2}$ s$^{-1}$ TeV$^{-1}$ and $\\alpha$ = 2.63 $\\pm$ 0.05, corresponding to an integrated flux above 1 TeV of 1.97 $\\times$ 10$^{-11}$ photons cm$^{-2}$ s$^{-1}$. The systematic error is estimated to be less than 30$\\%$ for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I$_0$ (E / 2 TeV)$^{-\\alpha}$ $\\exp$ (-E / E$_{cut}$), the lower limit of the cutoff energy E$_{cut}$ is 12 TeV, at 90$\\%$ confidence level. Our extended dataset allows the study of the TeV emission over lon...

  4. Status of LHAASO updates from ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Zhen

    2014-04-01

    The Large High Altitude Air Shower Observatory (LHAASO) is a multipurpose project with a complex detector array for high energy gamma ray and cosmic ray detection. The array of 1 km{sup 2} is composed of five types of detectors to measure shower arrival direction, total number of secondary particles, muon content, Cherenkov image and high energy gamma rays near shower core, respectively. The main scientific goals are (1) searching for galactic cosmic ray origins by extensive spectroscopy investigations of gamma ray sources above 30 TeV; (2) all sky survey for gamma ray sources at energies higher than 300 GeV; (3) energy spectrum and composition measurements of cosmic rays over a wide range covering knees with fixed energy scale and known fluxes for all species at the low energy end. In this paper, the progress on relevant detector developments is reported, including constructions of prototype detectors at Tibet site and coincidence operation with the ARGO-YBJ resistive plat chamber full coverage array at 4300 m a.s.l. The energy spectrum of cosmic ray hydrogen and Helium nuclei up to 0.8 PeV is reported as the first piece of physics measurements by the LHAASO experiment.

  5. DECISIONS, METHODS AND TECHNIQUES RELATED TO DECISION SUPPORT SYSTEMS (DSS

    Directory of Open Access Journals (Sweden)

    Boghean Florin

    2015-07-01

    Full Text Available Generalised uncertainty, a phenomenon that today’s managers are facing as part of their professional experience, makes it impossible to anticipate the way the business environment will evolve or what will be the consequences of the decisions they plan to implement. Any decision making process within the company entails the simultaneous presence of a number of economic, technical, juridical, human and managerial variables. The development and the approval of a decision is the result of decision making activities developed by the decision maker and sometimes by a decision support team or/and a decision support system (DSS. These aspects related to specific applications of decision support systems in risk management will be approached in this research paper. Decisions in general and management decisions in particular are associated with numerous risks, due to their complexity and increasing contextual orientation. In each business entity, there are concerns with the implementation of risk management in order to improve the likelihood of meeting objectives, the trust of the parties involved, increase the operational safety and security as well as the protection of the environment, minimise losses, improve organisational resilience in order to diminish the negative impact on the organisation and provide a solid foundation for decision making. Since any business entity is considered to be a wealth generator, the analysis of their performance should not be restricted to financial efficiency alone, but will also encompass their economic efficiency as well. The type of research developed in this paper entails different dimensions: conceptual, methodological, as well as empirical testing. Subsequently, the conducted research entails a methodological side, since the conducted activities have resulted in the presentation of a simulation model that is useful in decision making processes on the capital market. The research conducted in the present paper

  6. Highlights of the ARGO-YBJ Experiment at 4,300 m a.s.l

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Zhen, E-mail: caozh@ihep.ac.cn [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing (China)

    2014-07-01

    The ARGO-YBJ experiment in Tibet, China has been operated to survey the northern sky for gamma ray sources, transient or steady, for nearly 6 years. Many astrophysics observational results will be highlighted in this paper, such as the sky survey results, extended source observation, diffuse gamma rays from the galactic plane, and emission mechanism of AGNs and their flares. As the unique detector for EAS with a continuously sensitive area of 5,600 m2, the ARGO-YBJ array catches almost all particles in the central part of showers. The high-quality data set for showers above few TeV has been used for cosmic ray measurements such as the energy spectrum and composition. All those results are summarized here. As one of the next generation ground-based high-altitude air shower detector, LHAASO is briefly introduced as the successor of ARGO-YBJ in the end of the paper. (author)

  7. MAG-EPA reduces severity of DSS-induced colitis in rats.

    Science.gov (United States)

    Morin, Caroline; Blier, Pierre U; Fortin, Samuel

    2016-05-15

    Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EPA) in an in vivo rats model of UC induced by dextran sulfate sodium (DSS). DSS rats were untreated or treated per os with MAG-EPA. Morphological, histological, and biochemical analyses were performed following MAG-EPA administrations. Morphological and histological analyses revealed that MAG-EPA pretreatment (12 days pre-DSS) and treatment (6 days post-DSS) exhibited strong activity in reducing severity of disease in DSS rats. Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were markedly lower compared with rats treated only with DSS. MAG-EPA per os administration decrease neutrophil infiltration in colon tissues, as depicted by myelohyperoxidase activity. Results also revealed a reduced activation of NF-κB pathways correlated with a decreased expression of COX-2 in colon homogenates derived from MAG-EPA-pretreated and treated rats. Tension measurements performed on colon tissues revealed that contractile responses to methacholine and relaxing effect induced by sodium nitroprusside were largely increased following MAG-EPA treatment. The combined treatment of MAG-EPA and vitamin E displayed an antagonistic effect on anti-inflammatory properties of MAG-EPA in DSS rats.

  8. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis.

    Science.gov (United States)

    Carlsson, Anders H; Yakymenko, Olena; Olivier, Isabelle; Håkansson, Fathima; Postma, Emily; Keita, Asa V; Söderholm, Johan D

    2013-10-01

    OBJECTIVE. The intestinal microbiota plays a substantial role in the pathogenesis of inflammatory bowel disease (IBD). Faecalibacterium prausnitzii (FP) is underrepresented in IBD patients and have been suggested to have anti-inflammatory effects in mice. Increased intestinal permeability is common in IBD but the relationship between FP and intestinal barrier function has not been investigated. Our aim was to study treatment with FP supernatant on intestinal barrier function in a dextran sodium sulfate (DSS) colitis mice model. MATERIAL AND METHODS. C57BL/6 mice received 3% DSS in tap water ad libitum during five days to induce colitis. From day 3 the mice received a daily gavage with FP supernatant or broth during seven days. Ileum and colon were mounted in Ussing chambers for permeability studies with (51)Cr-EDTA and Escherichia coli K-12. Colon was saved for Western blot analyses of tight junction proteins. RESULTS. DSS-treated mice showed significant weight loss and colon shortening. Gavage with FP supernatant resulted in a quicker recovery after DSS treatment and less extensive colonic shortening. Ileal mucosa of DSS mice showed a significant increase in (51)Cr-EDTA-passage compared to controls. (51)Cr-EDTA passage was significantly decreased in mice receiving FP supernatant. No significant differences were observed in passage of E. coli K12. Western blots showed a trend to increased claudin-1 and claudin-2 expressions in DSS mice. CONCLUSIONS. Supernatant of FP enhances the intestinal barrier function by affecting paracellular permeability, and may thereby attenuate the severity of DSS-induced colitis in mice. These findings suggest a potential role of FP in the treatment of IBD.

  9. Sea surface freshening inferred from SMOS and ARGO salinity: impact of rain

    Directory of Open Access Journals (Sweden)

    J. Boutin

    2012-10-01

    Full Text Available The sea surface salinity (SSS measured from space by the Soil Moisture and Ocean Salinity (SMOS mission has recently been revisited by the European Space Agency first campaign reprocessing. We show that, with respect to the previous version, biases close to land and ice greatly decrease. The accuracy of SMOS SSS averaged over 10 days 100 × 100 km2 in the open ocean and estimated by comparison to ARGO SSS is on the order of 0.3–0.4 in tropical and subtropical regions and 0.5 in a cold region. The mean SSS −0.1 bias observed in the Tropical Pacific Ocean between 5° N and 15° N, relatively to other regions, is suppressed when SMOS rainy events, as detected on SSMIs rain rates, are removed from the SMOS-ARGO comparisons. The SMOS freshening is linearly correlated to SSMIs rain rate with a slope estimated to −0.14 mm−1 h, after correction for rain atmospheric contribution. This tendency is the signature of the temporal SSS variability between the time of SMOS and ARGO measurements linked to rain variability and of the vertical salinity stratification between the first centimeter of the sea surface layer sampled by SMOS and the 5 m depth sampled by ARGO. However, given that the whole set of collocations includes situations with rainy ARGO measurements collocated with non rainy SMOS measurements, the mean −0.1 bias and the negative skewness of the statistical distribution of SMOS minus ARGO SSS difference are very likely the mean signature of the vertical salinity stratification. In the future, the analysis of ongoing in situ salinity measurements in the top 50 cm of the sea surface and of Aquarius satellite SSS are expected to provide complementary information about the sea surface salinity stratification.

  10. Intraseasonal Oscillation in Global Ocean Temperature Inferred from Argo

    Institute of Scientific and Technical Information of China (English)

    HU Ruijin; WEI Meng

    2013-01-01

    The intraseasonal oscillation (ISO; 14-97-day periods) of temperature in the upper 2000 m of the global ocean was studied based on Argo observations from 2003-2008.It is shown that near the surface the ISO existed mainly in a band east of 60°E,between 10°S and 10°N,and the region around the Antarctic Circumpolar Current (ACC).At other levels analyzed,the ISOs also existed in the regions of the Kuroshio,the Gulf Stream,the Indonesian throughflow,the Somalia current,and the subtropical countercurrent (STCC) of the North Pacific.The intraseasonal signals can be seen even at depths of about 2000 m in some regions of the global ocean.The largest amplitude of ISO appeared at the thermocline of the equatorial Pacific,Atlantic and Indian Ocean,with maximum standard deviation (STD) exceeding 1.2℃.The ACC,the Kuroshio,and the Gulf Stream regions all exhibited large STD for all levels analyzed.Especially at 1000 m,the largest STD appeared in the south and southeast of South Africa-a part of the ACC,with a maximum value that reached 0.5℃.The ratios of the intraseasonal temperature variance to the total variance at 1000 m and at the equator indicated that,in a considerable part of the global deep ocean,the ISO was dominant in the variations of temperature,since such a ratio exceeded even 50% there.A case study also confirmed the existence of the ISO in the deep ocean.These results provide useful information for the design of field observations in the global ocean.Analysis and discussion are also given for the mechanism of the ISO.

  11. Argo and other tidal structures around the milky way

    Directory of Open Access Journals (Sweden)

    Helio J. Rocha-Pinto

    2006-01-01

    Full Text Available Se realiz o una b usqueda de sobredensidades que pudieran estar asociadas con subestructuras en el halo gal actico en bajas latitudes a partir de una muestra de gigantes M de 2MASS. Bajo la hip otesis de que las poblaciones estelares en la V a L actea exterior deber an de estar distribuidas de manera m as o menos sim etrica, se utilizaron dos m etodos para identi car asimetr as en la distribuci on (l; b de gigantes M de 2MASS que pudieran ser indicios de sobredensidades estelares: (1 la veri caci on directa de simetr a en campos re ejados sobre varios c rculos mayores sim etricos hipot eticos en la Galaxia; y (2 la extracci on de un modelo gal actico sim etrico para la distribuci on de gigantes M a partir de la distribuci on observada. Si bien podemos con rmar varios de los aspectos reportados previamente de la corriente de marea Monoceros, un hallazgo mayor de nuestro trabajo es que el n ucleo aparente del sistema Monoceros no se localiza en Canis Major, como lo han sugerido otras exploraciones, sino con mayor probabilidad a mayor l, en la regi on de la antigua constelaci on Argo (actualmente Puppis, Vela y Carina. Adem as del extenso sistema Monoceros, identi camos varias otras sobredensidades de gigantes M, principalmente a mayores distancias. Algunas de ellas corresponden a sistemas encontrados previamente en Triangulo-Andr omeda y Perseo, mientras que la naturaleza de otros de menor signi cado permanece incierta o puede ser atribuida a asimetr as de primer plano de estrellas enanas M contaminantes.

  12. Argos: Internacionalización en un entorno de conflicto armado Argos: Internacionalización en un entorno de conflicto armado*

    Directory of Open Access Journals (Sweden)

    Juan David Penagos Tascón

    2008-12-01

    Full Text Available This case study illustrates how Argos achieved to become one of the largest cement and concrete suppliers of Latin America, in spite of the fact that some of its production facilities are located in armed conflict areas. For that reason, the company implemented various corporate social responsibility strategies to overcome the difficulties of operating in these areas. These strategies contributed to the consolidation of the company’s operations under a single juridical and administrative entity, and facilitated the internationalization process to Central America, the Caribbean and the United States.Este caso de estudio empresarial muestra cómo la compañía Argos logró convertirseen uno de los proveedores de cemento y concreto más grandes de Latinoamérica,a pesar de que algunas de sus plantas productoras se encontraban ubicadas enzonas de conflicto armado, razón por la cual se desarrollaron diferentes iniciativasde responsabilidad social corporativa que permitieron operar en estas zonas.Garantizada la continuidad del negocio, las autoridades de Argos decidenconsolidar todas sus operaciones en una sola razón jurídica y administrativa yllevar a la empresa a un proceso de internacionalización en Centroamérica, Caribey Estados Unidos.

  13. The development of an EDSS: Lessons learned and implications for DSS research

    Science.gov (United States)

    El-Gayar, O.; Deokar, A.; Michels, L.; Fosnight, G.

    2011-01-01

    The Solar and Wind Energy Resource Assessment (SWERA) project is focused on providing renewable energy (RE) planning resources to the public. Examples include wind, solar, and hydro assessments. SWERA DSS consists of three major components. First, SWERA 'Product Archive' provides for a discovery DSS upon which users can find and access renewable energy data and supporting models. Second, the 'Renewable Resource EXplorer' (RREX) component serves as a web-based, GIS analysis tool for viewing RE resource data available through the SWERA Product Archive. Third, the SWERA web service provides computational access to the data available in the SWERA spatial database through a location based query, and is also utilized in the RREX component. We provide a discussion of various design decisions used in the construction of this EDSS, followed by project experiences and implications for EDSS and broader DSS research. ?? 2011 IEEE.

  14. Üks suund, kaks vaadet / Tiit Land, Argo Ralja ; intervjueerinud Katrin Reimann

    Index Scriptorium Estoniae

    Land, Tiit, 1964-

    2012-01-01

    Intervjuu Tallinna Ülikooli rektori Tiit Landi ja Üliõpilaskonna juhatuse esimehe Argo Raljaga Tallinna Ülikooli iseloomustavatest märksõnadest möödunud aastal, positsioonist Eesti hariduses, ülikooli koostööst instituutide ja kolledžitega

  15. Aptychi from the Lower Cretaceous strata along the Río Argos (Caravaca, SE Spain)

    NARCIS (Netherlands)

    Vašícek, Z.; Hoedemaeker, Ph.J.

    1997-01-01

    The aptychi of the Berriasian to Barremian strata of the Río Argos succession near Caravaca (SE Spain) are described. One new subspecies is introduced, Lamellaptychus angulocostatus gracilicostatus, from the latest Hauterivian Ohmi Zone (ammonite zone). Like in the Eastern Alps also in Southern Spai

  16. Measurement of the angular resolution of the ARGO-YBJ detector

    CERN Document Server

    Di Sciascio, G

    2007-01-01

    The ARGO-YBJ experiment is a full coverage EAS-array installed at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China). We present the results on the angular resolution measured with different methods with the full central carpet. The comparison of experimental results with MC simulations is discussed.

  17. Search for Gamma Ray Bursts with the Argo-YBJ Detector in Scaler Mode

    CERN Document Server

    Aielli, G

    2009-01-01

    We report on the search for Gamma Ray Bursts (GRBs) in the energy range 1-100 GeV in coincidence with the prompt emission detected by satellites using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) air shower detector. Thanks to its mountain location (Yangbajing, Tibet, P.R. China, 4300 m a.s.l.), active surface (about 6700 m**2 of Resistive Plate Chambers), and large field of view (about 2 sr, limited only by the atmospheric absorption), the ARGO-YBJ air shower detector is particularly suitable for the detection of unpredictable and short duration events such as GRBs. The search is carried out using the "single particle technique", i.e. counting all the particles hitting the detector without measurement of the energy and arrival direction of the primary gamma rays. Between 2004 December 17 and 2009 April 7, 81 GRBs detected by satellites occurred within the field of view of ARGO-YBJ (zenith angle 1 GeV counterpart in the ARGO-YBJ data finding no statistically significant e...

  18. Vertical temperature dynamics in the Northern Baltic Sea based on 3D modelling and data from shallow-water Argo floats

    Science.gov (United States)

    Westerlund, Antti; Tuomi, Laura

    2016-06-01

    3D hydrodynamic models often produce errors in the depth of the mixed layer and the vertical density structure. We used the 3D hydrodynamic model NEMO to investigate the effect of vertical turbulence parameterisations on seasonal temperature dynamics in the Bothnian Sea, Baltic Sea for the years 2012 and 2013. We used vertical profiles from new shallow-water Argo floats, operational in the area since 2012, to validate our model. We found that NEMO was able to reproduce the general features of the seasonal temperature variations in the study area, when meteorological forcing was accurate. The k-ε and k-ω schemes were selected for a more detailed analysis. Both schemes showed clear differences, but neither proved superior. While sea surface temperature was better simulated with the k-ω scheme, thermocline depth was clearly better with the k-ε scheme. We investigated the effect of wave-breaking on the mixing of the surface layer. The Craig and Banner parameterisation clearly improved the representation of thermocline depth. However, further tuning of the mixing parameterisations for the Baltic Sea is needed to better simulate the vertical temperature structure. We found the autonomous Baltic Sea Argo floats valuable for model validation and performance evaluation.

  19. Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat.

    Science.gov (United States)

    Martin, Jérôme C; Bériou, Gaëlle; Josien, Régis

    2016-01-01

    Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulfate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs. This section provides with a detailed protocol that we validated in our laboratory to perform DSS-induced acute colitis in the Sprague-Dawley (SPD) rat.

  20. 决策支持系统(DSS)的研究与发展%Research and Development of the Decision Supporting System (DSS)

    Institute of Scientific and Technical Information of China (English)

    李珊

    2001-01-01

    分析了决策支持系统(DSS)在计算机管理领域中模型、专用及生成工具、结构、决策风格的研究现状,结合实际论述了DSS群体、智能、分布以及集成化的发展趋向。

  1. A NEW DSS BASED ON INTRANET AND DATA WAREHOUSE%Intranet 环境下基于数据仓库技术的新型DSS

    Institute of Scientific and Technical Information of China (English)

    张华雨; 韩伯棠; 覃云

    2002-01-01

    文中构造了一种Intranet环境下基于数据仓库技术的新型决策支持系统(DSS)的框架,并与传统的DSS进行比较,分析其优势,指出此新型DSS是今后决策支持系统的发展方向.

  2. Temperature, salinity and dissolved oxygen profile data from globally distributed Argo profiling floats through the month of September 2016 for the Global Argo Data Repository, 1995-09-07 to 2016-09-30 (NODC Accession 0042682)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent all data collected from Argo profiling floats through the current month (September 2016). The NOAA National Centers for Environmental...

  3. No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats

    Directory of Open Access Journals (Sweden)

    Gülen Arslan

    2007-01-01

    Full Text Available Background: Omega-3 (n-3 polyunsaturated fatty acids (PUFAs have modulating effects in several chronic inflammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation with n-3 (fish or seal oil or n-6 (soy oil PUFA rich oils would protect the development of dextran sulfate sodium (DSS-induced colitis in rats.Methods: Forty-eight male Wistar rats were divided into 6 groups: no intervention, sham, DSS, seal oil + DSS, fi sh oil +DSS and soy oil + DSS. Following 7 days of acclimatisation, 1 mL oil (seal, fish or soy or distilled water (sham was administered by gavage day 8 to 14. Colitis was induced by 5% DSS in drinking water from day 15 to 21. Rats were sacrificed on day 23. Histological colitis (crypt and inflammation scores, faecal granulocyte marker protein (GMP and quantitative fatty acid composition in red blood cells were measured.Results: Pretreatment with fish or seal oils did not significantly influence DSS induced inflammation. In fact, all the oils tended to exacerbate the inflammation. Soy oil increased the mean crypt score (P < 0.04, but not the inflammation score or GMP. The ratio of n-6 to n-3 fatty acids (FAs was 11 to 1 and 10 to 1 in standard diet and in red blood cells of control rats, respectively. Following administration of DSS, the ratio fell in all treatment groups (P < 0.001. The lowest ratios were seen in the groups receiving DSS + fi sh or seal oils (around 6 to 1.Conclusion: Short-term pretreatment with fish or seal oils did not protect against subsequent induction of colitis by DSS in this rat model. Whether the high ratio of n-6 to n-3 FAs in the standard diet concealed effects of n-3 FA supplementation should be further investigated.

  4. CRED SVP Drifting Buoy Argos_ID 24753 Data in American Samoa, 200307-200407 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24753 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  5. CRED SVP Drifting Buoy Argos_ID 35648 Data Pago Pago, American Samoa, 200203-200204 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 35648 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  6. CRED SVP Drifting Buoy Argos_ID 44765 Data, Manua in the American Samoa, 200402-200406 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 44765 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  7. CRED APEX Drifting Buoy Argos_ID 25330 Data Maro Reef, Northwestern Hawaiian Islands, 200109-200201 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 25330 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  8. CRED SVP Drifting Buoy Argos_ID 30147 Data Nihoa, Northwestern Hawaiian Islands, 200209-200501 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30147 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  9. CRED SVP Drifting Buoy Argos_ID 29099 Data, Rota in the Marianas Archipelago, 200309-200402 (NODC Accession 0067473)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29099 was deployed in the region of Marianas Archipelago to assess ocean currents and sea surface temperature. SVP drifter data files...

  10. CRED SVP Drifting Buoy Argos_ID 52299 Data, Arakane in the Marianas Archipelago, 200509-200607 (NODC Accession 0067473)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 52299 was deployed in the region of the Marianas Archipelago to assess ocean currents and sea surface temperature. drifter data files...

  11. CRED SVP Drifting Buoy Argos_ID 30225 Data in the Northwestern Hawaiian Islands, 200209-200401 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30225 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  12. CRED SVP Drifting Buoy Argos_ID 29938 Data in the Northwestern Hawaiian Islands, 200209-200312 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29938 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  13. CRED SVP Drifting Buoy Argos_ID 35650 Swain's Atoll, American Samoa, 200202-200211 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 35650 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  14. CRED SVP Drifting Buoy Argos_ID 24666 Data in the American Samoa, 200309-200503 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24666 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  15. CRED SVP Drifting Buoy Argos_ID 35646 Data in the American Samoa, 200202-200302 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 35646 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  16. Can DSS Technology Improve Group Decision Performance for End Users?: An Experimental Study.

    Science.gov (United States)

    Gundersen, David E.; And Others

    1995-01-01

    Examines the benefits of Decision Support Systems (DSS) for end-user group decision making. An experiment was conducted which required groups to reach a consensus on human resource-related decisions. The results of the experiment provide implications for the use of group DDS in organizations and for future study. (Author/AEF)

  17. Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice.

    Science.gov (United States)

    Håkansson, Å; Tormo-Badia, N; Baridi, A; Xu, J; Molin, G; Hagslätt, M-L; Karlsson, C; Jeppsson, B; Cilio, C M; Ahrné, S

    2015-02-01

    Ulcerative colitis (UC) is characterized by chronic inflammation of the colonic mucosa. Administration of dextran sulfate sodium (DSS) to animals is a frequently used model to mimic human colitis. Deregulation of the immune response to the enteric microflora or pathogens as well as increased intestinal permeability have been proposed as disease-driving mechanisms. To enlarge the understanding of the pathogenesis, we have studied the effect of DSS on the immune system and gut microbiota in mice. Intestinal inflammation was verified through histological evaluation and myeloperoxidase activity. Immunological changes were assessed by flow cytometry in spleen, Peyer's patches and mesenteric lymph nodes and through multiplex cytokine profiling. In addition, quantification of the total amount of bacteria on colonic mucosa as well as the total amount of lactobacilli, Akkermansia, Desulfovibrio and Enterobacteriaceae was performed by the use of quantitative PCR. Diversity and community structure were analysed by terminal restriction fragment length polymorphism (T-RFLP) patterns, and principal component analysis was utilized on immunological and T-RFLP patterns. DSS-induced colitis show clinical and histological similarities to UC. The composition of the colonic microflora was profoundly changed and correlated with several alterations of the immune system. The results demonstrate a relationship between multiple immunological changes and alterations of the gut microbiota after DSS administration. These data highlight and improve the definition of the immunological basis of the disease and suggest a role for dysregulation of the gut microbiota in the pathogenesis of colitis.

  18. A Framework of the Decision Support System (DSS) for Higher Education Appropriate Scale

    Institute of Scientific and Technical Information of China (English)

    ZHAI Li-li; GAO Chang-yuan; HAO Hong-jun

    2002-01-01

    According to the relation of the developing speed and scale of higher education and those of national economy, the establishing method and structure of higher education appropriate scale DSS (HEASDSS) are researched applying to educational economic principle and decision support system theory.

  19. The Contribution of DSS to Limiting Differences in Decisions between Successful and Unsuccessful Teachers

    Science.gov (United States)

    Klein, Joseph

    2007-01-01

    This study examined the contribution of a Decision Support System (DSS) to minimizing differences between the educational decisions of 310 teachers who were classified, according to the teaching skill categories of the NBPTS, as excellent, mediate, or poor. The teachers were asked to analyze the same educational dilemma, once intuitively and a…

  20. Afforest sDSS: a metamodel based spatial decision support system for afforestation of agricultural land

    NARCIS (Netherlands)

    Gilliams, S.; Orshoven, van J.; Muys, B.; Kros, J.; Heil, G.W.; Deursen, van W.

    2005-01-01

    The concept and structure of the Spatial Decision Support System AFFOREST sDSS dealing with environmental performance (EP) of afforestation on agricultural land in northwestern Europe, is presented. EP is defined in terms of three environmental impact categories: (1) carbon sequestration (2) groundw

  1. Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair

    DEFF Research Database (Denmark)

    Zhou, Qingwen; Kojic, Milorad; Cao, Zhimin;

    2007-01-01

    Brh2, the BRCA2 ortholog in Ustilago maydis, enables recombinational repair of DNA by controlling Rad51 and is in turn regulated by Dss1. Interplay with Rad51 is conducted via the BRC element located in the N-terminal region of the protein and through an unrelated domain, CRE, at the C terminus...

  2. Potential availability of diesel waste heat at Echo Deep Space Station (DSS 12)

    Science.gov (United States)

    Hughes, R. D.

    1982-01-01

    Energy consumption at the Goldstone Echo Deep Space Station (DSS 12) is predicted and quantified for a future station configuration which will involve implementation of proposed energy conservation modifications. Cogeneration by the utilization of diesel waste-heat to satisfy site heating and cooling requirements of the station is discussed. Scenarios involving expanded use of on-site diesel generators are presented.

  3. Error attribution and validation of SMOS high-level salinity products with Argo data

    Science.gov (United States)

    Ballabrera, Joaquim

    2015-04-01

    In the context of the E-AIMS project (7FP Project No. 284391), the role and suggested improvements of the Argo array in the validation of SMOS sea surface salinity (SSS) have been investigated. Here, a summary of the main results is shown and discussed. The Argo array continues to be the sole component of the ocean observing system to provide routine observations of temperature and salinity profiles at global scale with a time sampling period of about ten days. The observations provided by an Argo profiler are publicly available a few days from being taken (Real Time Mode) after application of automatic quality control filters. Scientific quality data (Delayed Mode) is generated after a human supervised quality control. In this study, the highest quality, delayed mode, near-the-surface data are being used to validate the SSS Level 3 and Level 4 products generated by the SMOS Barcelona Expert Centre (http://cp34-bec.cmima.csic.es). The products being validated here are the weighted binned average (L3), an Optimal Interpolation (OI), and a data fused product exploiting the spatial variability of OSTIA SST. An Argo profile is considered if its quality flags of position and time are equal to one (good), two (probably good), five (value changes) or eight (value interpolated). However, temperature, salinity and pressure data are used only if their quality flags are equal to one (good). The uppermost (but deeper than 0.5 m) salinity measurement is taken as an approximation of the in-situ SSS, but only if the salinity profile allows a robust interpolation of the salinity at 7.5 m (this additional requirement is introduced to ensure that the salinity profile is properly sampled near the surface). At the moment of performing this study, the main drawbacks have been the lag in the Delayed Mode processing, and the lack of salinity observations in the first five meters below the ocean surface. While 5500 profiles in Delayed Mode were available for January 2011, about 1000 were

  4. Enhancing the use of Argos satellite data for home range and long distance migration studies of marine animals.

    Directory of Open Access Journals (Sweden)

    Xavier Hoenner

    Full Text Available Accurately quantifying animals' spatial utilisation is critical for conservation, but has long remained an elusive goal due to technological impediments. The Argos telemetry system has been extensively used to remotely track marine animals, however location estimates are characterised by substantial spatial error. State-space models (SSM constitute a robust statistical approach to refine Argos tracking data by accounting for observation errors and stochasticity in animal movement. Despite their wide use in ecology, few studies have thoroughly quantified the error associated with SSM predicted locations and no research has assessed their validity for describing animal movement behaviour. We compared home ranges and migratory pathways of seven hawksbill sea turtles (Eretmochelys imbricata estimated from (a highly accurate Fastloc GPS data and (b locations computed using common Argos data analytical approaches. Argos 68(th percentile error was 4 km for LC ≤ 0. Argos error structure was highly longitudinally skewed and was, for all LC, adequately modelled by a Student's t distribution. Both habitat use and migration routes were best recreated using SSM locations post-processed by re-adding good Argos positions (LC 1, 2 and 3 and filtering terrestrial points (mean distance to migratory tracks ± SD = 2.2 ± 2.4 km; mean home range overlap and error ratio = 92.2% and 285.6 respectively. This parsimonious and objective statistical procedure however still markedly overestimated true home range sizes, especially for animals exhibiting restricted movements. Post-processing SSM locations nonetheless constitutes the best analytical technique for remotely sensed Argos tracking data and we therefore recommend using this approach to rework historical Argos datasets for better estimation of animal spatial utilisation for research and evidence-based conservation purposes.

  5. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization.

    Science.gov (United States)

    Lin, Yuli; Yang, Xuguang; Yue, Wenjie; Xu, Xiaofei; Li, Bingji; Zou, Linlin; He, Rui

    2014-07-01

    Chemerin is present in various inflammatory sites and is closely involved in tissue inflammation. Recent studies have demonstrated that chemerin treatment can cause either anti-inflammatory or pro-inflammatory effects according to the disease model being investigated. Elevated circulating chemerin was recently found in patients with inflammatory bowel disease (IBD); however, the role of chemerin in intestinal inflammation remains unknown. In this study, we demonstrated that the administration of exogenous chemerin (aa17-156) aggravated the severity of dextran sulfate sodium (DSS)-induced colitis, which was characterized by higher clinical scores, extensive mucosal damage and significantly increased local and systemic production of pro-inflammatory cytokines, including IL-6, TNF-α and interferon (IFN-γ). Interestingly, chemerin did not appear to influence the magnitudes of inflammatory infiltrates in the colons, but did result in significantly decreased colonic expression of M2 macrophage-associated genes, including Arginase 1 (Arg-1), Ym1, FIZZ1 and IL-10, following DSS exposure, suggesting an impaired M2 macrophage skewing in vivo. Furthermore, an in vitro experiment showed that the addition of chemerin directly suppressed M2 macrophage-associated gene expression and STAT6 phosphorylation in IL-4-stimulated macrophages. Significantly elevated chemerin levels were found in colons from DSS-exposed mice and from ulcerative colitis (UC) patients and appeared to positively correlate with disease severity. Moreover, the in vivo administration of neutralizing anti-chemerin antibody significantly improved intestinal inflammation following DSS exposure. Taken together, our findings reveal a pro-inflammatory role for chemerin in DSS-induced colitis and the ability of chemerin to suppress the anti-inflammatory M2 macrophage response. Our study also suggests that upregulated chemerin in inflamed colons may contribute to the pathogenesis of IBD.

  6. Sea surface freshening inferred from SMOS and ARGO salinity: impact of rain

    Directory of Open Access Journals (Sweden)

    J. Boutin

    2013-02-01

    Full Text Available The sea surface salinity (SSS measured from space by the Soil Moisture and Ocean Salinity (SMOS mission has recently been revisited by the European Space Agency first campaign reprocessing. We show that, with respect to the previous version, biases close to land and ice greatly decrease. The accuracy of SMOS SSS averaged over 10 days, 100 × 100 km2 in the open ocean and estimated by comparison to ARGO (Array for Real-Time Geostrophic Oceanography SSS is on the order of 0.3–0.4 in tropical and subtropical regions and 0.5 in a cold region. The averaged negative SSS bias (−0.1 observed in the tropical Pacific Ocean between 5° N and 15° N, relatively to other regions, is suppressed when SMOS observations concomitant with rain events, as detected from SSM/Is (Special Sensor Microwave Imager rain rates, are removed from the SMOS–ARGO comparisons. The SMOS freshening is linearly correlated to SSM/Is rain rate with a slope estimated to −0.14 mm−1 h, after correction for rain atmospheric contribution. This tendency is the signature of the temporal SSS variability between the time of SMOS and ARGO measurements linked to rain variability and of the vertical salinity stratification between the first centimeter of the sea surface layer sampled by SMOS and the 5 m depth sampled by ARGO. However, given that the whole set of collocations includes situations with ARGO measurements concomitant with rain events collocated with SMOS measurements under no rain, the mean −0.1 bias and the negative skewness of the statistical distribution of SMOS minus ARGO SSS difference are very likely the mean signature of the vertical salinity stratification. In the future, the analysis of ongoing in situ salinity measurements in the top 50 cm of the sea surface and of Aquarius satellite SSS are expected to provide complementary information about the sea surface salinity stratification.

  7. Mesoscale variability of water masses in the Arabian Sea as revealed by ARGO floats

    Directory of Open Access Journals (Sweden)

    X. Carton

    2012-03-01

    Full Text Available By analysing ARGO float data over the last four years, a few aspects of the mesoscale variability of water masses in the Arabian Sea are described.

    The Red Sea Outflow Water (RSOW is concentrated in the Southwestern Gulf of Aden, in particular when a cyclonic gyre predominates in this region. Salinities of 36.5 and temperatures of 16 °C are found in this area at depths between 600 and 1000 m. RSOW is more dilute in the eastern part of the Gulf, where intense and relatively barotropic gyres mix it with Indian ocean Central Water. RSOW is also detected along the northeastern coast of Socotra, and fragments of RSOW are found between one and three degrees of latitude north of this island. In the whole Gulf of Aden, the correlation between the deep motions of the floats and the sea-level anomaly measured by altimetry is strong, at regional scale. The finer scale details of the float trajectories are not sampled by altimetry and are often related to the anomalous water masses that the floats encounter.

    The Persian Gulf Water (PGW is found in the float profiles near Ras ash Sharbatat (near 57° E, 18° N, again with 36.5 in salinity and about 18–19 °C in temperature. These observations were achieved in winter when the southwestward monsoon currents can advect PGW along the South Arabian coast. Fragments of PGW were also observed in the Arabian Sea between 18 and 20° N and 63 and 65° E in summer, showing that this water mass can escape the Gulf of Oman southeastward, during that season.

    Kinetic energy distributions of floats with respect to distance or angle share common features between the two regions (Gulf of Aden and Arabian Sea, in particular peaks at 30, 50 and 150 km scales and along the axis of monsoon currents. Hydrological measurements by floats are also influenced by the seasonal variations of PGW and RSOW in these regions.

  8. Dried Saliva Spot (DSS) as a Convenient and Reliable Sampling for Bioanalysis: An Application for the Diagnosis of Diabetes Mellitus.

    Science.gov (United States)

    Numako, Masahiro; Takayama, Takahiro; Noge, Ichiro; Kitagawa, Yutaka; Todoroki, Kenichiro; Mizuno, Hajime; Min, Jun Zhe; Toyo'oka, Toshimasa

    2016-01-01

    This paper proposes the dried saliva spot (DSS) as a convenient sampling technique for bioanalysis. The analytical method with the DSS was used for the determination of D,L-lactic acid (D,L-LA) and the D/L ratio of diabetic patients and prediabetic persons for the simple screening of the disease. The D,L-LA in the DSS was labeled with a chiral reagent (DMT-3(S)-Apy) for carboxylic acids and determined by UPLC-ESI-MS/MS. The limits of detection (signal-to-noise ratio (S/N) = 3) for the DSS analysis were on the amol level (∼30 amol). Because good stability, recovery, accuracy, and precision of the D,L-LA for the DSS method was also obtained from the proposed procedure, the DSS method was applied to the determination of the D- and L-isomers of LA of diabetic patients, and prediabetic and healthy persons. The D/L-LA ratio by the present DSS method and the HbA1c value in blood were well-correlated to the serious diabetic patients, whereas the relation in the prediabetic persons was not very good. The reason seems to be due to the rough saliva sampling, and not to the DSS method, because strict regulation was not requested for the prediabetic and healthy persons. In order to have a successful DSS analysis, the stability of the target molecule, the detection sensitivity to the target molecule, and the validated determination method are important.

  9. DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model.

    Science.gov (United States)

    Achiwa, Koichi; Ishigami, Masatoshi; Ishizu, Yoji; Kuzuya, Teiji; Honda, Takashi; Hayashi, Kazuhiko; Hirooka, Yoshiki; Katano, Yoshiaki; Goto, Hidemi

    2016-01-29

    Nonalcoholic steatohepatitis (NASH) patients progress to liver cirrhosis and even hepatocellular carcinoma (HCC). Several lines of evidence indicate that accumulation of lipopolysaccharide (LPS) and disruption of gut microbiota play contributory roles in HCC. Moreover, in a dextran sodium sulfate (DSS)-induced colitis model in mice, a high-fat diet increases portal LPS level and promotes hepatic inflammation and fibrosis. However, this diet-induced NASH model requires at least 50 weeks for carcinogenesis. In this study, we sought to determine whether increased intestinal permeability would aggravate liver inflammation and fibrosis and accelerate tumorigenesis in a diet-induced NASH model. Mice were fed a choline-deficient high-fat (CDHF) diet for 4 or 12 weeks. The DSS group was fed CDHF and intermittently received 1% DSS in the drinking water. Exposure to DSS promoted mucosal changes such as crypt loss and increased the number of inflammatory cells in the colon. In the DSS group, portal LPS levels were elevated at 4 weeks, and the proportions of Clostridium cluster XI in the fecal microbiota were elevated. In addition, levels of serum transaminase, number of lobular inflammatory cells, F4/80 staining-positive area, and levels of inflammatory cytokines were all elevated in the DSS group. Liver histology in the DSS group revealed severe fibrosis at 12 weeks. Liver tumors were detected in the DSS group at 12 weeks, but not in the other groups. Thus, DSS administration promoted liver tumors in a CDHF diet-induced NASH mouse over the short term, suggesting that the induction of intestinal inflammation and gut disruption of microbiota in NASH promote hepatic tumorigenesis.

  10. GT Solar公司最新推出DSS450HP铸锭炉%GT Solar introduces new DSS450HP ingot growth furnace

    Institute of Scientific and Technical Information of China (English)

    鹏飞

    2010-01-01

    @@ 为全球太阳能行业提供专业生产设备、工艺技术和整线交钥匙工程服务的GT Solar公司日前发布了一款高性能铸锭炉DSS450HPTM,它配备有一个经过传热优化的第二代热场,可提高处理能力,同时提供业界一流的晶体质量.

  11. Typical Surface Seasonal Circulation in the Indian Ocean Derived from Argos Floats

    Institute of Scientific and Technical Information of China (English)

    ZHENG Shao-Jun; ZHANG Yu-Hong; ZHUANG Wei; LI Jia-Xun; DU Yan

    2012-01-01

    This study investigates the surface circulation in the Indian Ocean using Argos float data over the period 1979--2011. The Argos observations manifest some new phenomena. The climatological annual mean circulation shows that the surface current becomes much stronger after turning around in shore in the western Indian Ocean. In the tropical Indian Ocean, the Great Whirl (GW) to the east of Somalia develops quickly in spring (April-May) as the monsoon reverses to move northward, becoming strongest in summer (June-September) and disappearing in autumn (October-November). The west end of the Agulhas retroflection can reach 18°E, and it exhibits a seasonal variation. At approximately 90°E, the Agulhas Return Current combines with the eastward South Atlantic Current and finally joins the Antarctic Circumpolar Current.

  12. Observation of TeV gamma ray extended sources with ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Vernetto, Silvia, E-mail: vernetto@to.infn.it

    2014-04-01

    More than 80% of TeV galactic gamma ray sources are spatially extended and many of them are still unidentified. The extended emission could be the result of cosmic ray interactions with the ambient medium which provides the target to produce TeV gamma rays. The sensitivity of ground based gamma ray detectors decreases for extended sources; shower detectors, due to their large field of view, are less affected with respect to Cherenkov telescopes. The ARGO-YBJ experiment (Yangbajing Cosmic Ray Laboratory, Tibet, China, 4300 m of altitude) is an air shower detector devoted to gamma ray astronomy at energies above a few hundred GeV, with an integrated sensitivity ranging from 0.24 to ∼1 Crab units, depending on the source declination. In this paper the observation of galactic extended sources with ARGO-YBJ during 5 years is reviewed.

  13. Gamma rays from dark matter annihilation in the Draco and observability at ARGO

    CERN Document Server

    Bi, X J; Zhang, X; Bi, Xiao-Jun; Hu, Hong-Bo; Zhang, Xinmin

    2006-01-01

    The CACTUS experiment recently observed a gamma ray excess above 50 GeV from the direction of the Draco dwarf spheroidal galaxy. Considering that Draco is dark matter dominated the gamma rays may be generated through dark matter annihilation in the Draco halo. In the framework of the minimal supersymmetric extension of the standard model we explore the parameter space to account for the gamma ray signals at CACTUS. We find that the neutralino mass is constrained to be approximately in the range between 100 GeV ~ 400 GeV and a sharp central cuspy of the dark halo profile in Draco is necessary to explain the CACTUS results. We then discuss further constraints on the supersymmetric parameter space by observations at the ground based ARGO detector. It is found that the parameter space can be strongly constrained by ARGO if no excess from Draco is observed above 100 GeV.

  14. Tropical Cyclone Footprint in the Ocean Mixed Layer Observed by Argo in the Northwest Pacific

    Science.gov (United States)

    2014-10-25

    energy input to the ocean induced by tropical cyclones , J. Phys. Oceanogr., 38, 1253–1266. Liu, Z., J. Xu, B. Zhu, C. Sun, and L. Zhang (2007), The upper...RESEARCH ARTICLE 10.1002/2014JC010316 Tropical cyclone footprint in the ocean mixed layer observed by Argo in the Northwest Pacific HongLi Fu1...Postgraduate School, Monterey, California, USA Abstract This study systematically investigated the ocean mixed layer responses to tropical cyclone (TC

  15. Global representation of tropical cyclone-induced short-term ocean thermal changes using Argo data

    OpenAIRE

    Cheng, L.; J. Zhu; R. L. Sriver

    2015-01-01

    Argo floats are used to examine tropical cyclone (TC) induced ocean thermal changes on the global scale by comparing temperature profiles before and after TC passage. We present a footprint method that analyzes cross-track thermal responses along all storm tracks during the period 2004–2012. We combine the results into composite representations of the vertical structure of the average thermal response for two different categories: tropical storms/tropical depressions (TS/TD)...

  16. Study of the diffuse gamma-ray emission from the Galactic plane with ARGO-YBJ

    CERN Document Server

    Bartoli, B; Bi, X J; Branchini, P; Budano, A; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Chen, S Z; Chen, T L; Creti, P; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liguori, G; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Panareo, M; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2015-01-01

    The events recorded by ARGO-YBJ in more than five years of data collection have been analyzed to determine the diffuse gamma-ray emission in the Galactic plane at Galactic longitudes 25{\\deg} < l < 100{\\deg} and Galactic latitudes . The energy range covered by this analysis, from ~350 GeV to ~2 TeV, allows the connection of the region explored by Fermi with the multi-TeV measurements carried out by Milagro. Our analysis has been focused on two selected regions of the Galactic plane, i.e., 40{\\deg} < l < 100{\\deg} and 65{\\deg} < l < 85{\\deg} (the Cygnus region), where Milagro observed an excess with respect to the predictions of current models. Great care has been taken in order to mask the most intense gamma-ray sources, including the TeV counterpart of the Cygnus cocoon recently identified by ARGO-YBJ, and to remove residual contributions. The ARGO-YBJ results do not show any excess at sub-TeV energies corresponding to the excess found by Milagro, and are consistent with the predictions of ...

  17. The Argo Simulation: II. The Early Build-up of the Hubble Sequence

    CERN Document Server

    Feldmann, Robert

    2014-01-01

    The Hubble sequence is a common classification scheme for the structure of galaxies. Despite the tremendous usefulness of this diagnostic, we still do not fully understand when, where, and how this morphological ordering was put in place. Here, we investigate the morphological evolution of a sample of 22 high redshift ($z\\geq3$) galaxies extracted from the Argo simulation. Argo is a cosmological zoom-in simulation of a group-sized halo and its environment. It adopts the same high resolution ($\\sim10^4$ M$_\\odot$, $\\sim100$ pc) and sub-grid physical model that was used in the Eris simulation but probes a sub-volume almost ten times bigger with as many as 45 million gas and star particles in the zoom-in region. Argo follows the early assembly of galaxies with a broad range of stellar masses ($\\log M_{\\star}/{\\rm M}_{\\odot}\\sim8-11$ at $z\\simeq3$), while resolving properly their structural properties. We recover a diversity of morphologies, including late-type/irregular disc galaxies with flat rotation curves, s...

  18. Geophysical investigations near the ancient Agora at the city of Argos, Greece

    Science.gov (United States)

    Zananiri, Irene; Hademenos, Vassilios; Piteros, Christos

    2010-06-01

    It is possible to reduce risk in archaeological excavations by identifying areas of high potential at an early stage and locating trenches accordingly. Towards this goal, a non-invasive geophysical survey was carried out at the city of Argos, which from the beginning of Archaic Times and through to Classical Times was one of the most prominent city-states. Based on historical and archaeological evidence, two sites were chosen near the ancient Agora of Argos. Total field and gradient magnetic measurements were collected over several grids, with 1 m spacing between measurement points. Representative samples were taken for laboratory measurements of the low-field magnetic susceptibility. Mapping, filtering and inversion procedures of the magnetic data have been used in tandem. The data management and cartographic representation was performed using Geographic Information Systems, where a geographic database was created, including all available information for the broader Argos area. The results of the geophysical survey were able to highlight the presence of linear and square structures possibly representing inhabitance ruins, namely small building remnants and road foundations according to observations from neighbouring excavations. Thus, the authors were able to suggest to the archaeologists excavation tests on the basis of the residual magnetic map.

  19. Energy spectrum of cosmic ray protons and helium nuclei measured by the ARGO-YBJ experiment

    Energy Technology Data Exchange (ETDEWEB)

    Mari, S.M. [Dipartimento di Matematica e Fisica - Università degli Studi Roma TRE, via della Vasca Navale 84, 00146 Roma (Italy); Istituto Nazionale di Fisica Nucleare - Sezione di Roma TRE, via della Vasca Navale 84, 00146 Roma (Italy); Montini, P., E-mail: paolo.montini@roma3.infn.it [Istituto Nazionale di Fisica Nucleare - Sezione di Roma TRE, via della Vasca Navale 84, 00146 Roma (Italy)

    2014-04-01

    The ARGO-YBJ experiment is a full-coverage air shower detector operating at the Yangbajing International Cosmic Ray Observatory (Tibet, PR China, 4300 m a.s.l.). The detector was in stable data taking in its full configuration from November 2007 to February 2013. More than 5×10{sup 11} events have been collected and reconstructed. Due to its characteristics (full-coverage, high segmentation, high altitude operation) the ARGO-YBJ experiment is able to investigate the cosmic ray energy spectrum in a wide energy range and offer the possibility of measuring the cosmic ray light component spectrum down to the TeV region, where direct balloon-borne measurements are available. In this work we present the measurement of the proton and helium spectra in the energy range 1–300 TeV by using a large data sample collected between January 2008 and December 2011. - Highlights: • We have measured the light component spectrum of cosmic rays. • The measurement has been performed by the full coverage high altitude ARGO-YBJ experiment. • The measurement covers the energy range 1–300 TeV where direct measurements are available.

  20. A DSS based on GIS and Tabu search for solving the CVRP: The Tunisian case

    Directory of Open Access Journals (Sweden)

    Sami Faiz

    2014-06-01

    Full Text Available The Capacitated Vehicle Routing Problem (CVRP is a well known optimization problem applied in numerous applications. It consists of delivering items to some geographically dispersed customers using a set of vehicles operating from a single depot. As the CVRP is known to be NP-hard, approximate methods perform well when generating promising sub-optimal solutions in a reasonable computation time. In this paper, we develop a Decision Support System (DSS for solving the CVRP that integrates a Geographical Information System (GIS enriched by a Tabu search (TS module. In order to demonstrate the performance of the proposed DSS in terms of CPU runtime and minimized traveled distance, we apply it on a large-sized real case. The results are then highlighted in a cartographic format using Google Maps.

  1. Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model.

    Science.gov (United States)

    Huo, Xiaowei; Liu, Dongyu; Gao, Li; Li, Liyong; Cao, Li

    2016-08-24

    Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated carcinogenesis (CAC). Thus, it is well accepted that ameliorating inflammation creates a potential to achieve an inhibitory effect on CAC. Licorice flavonoids (LFs) possess strong anti-inflammatory activity, making it possible to investigate its pharmacologic role in suppressing CAC. The purpose of the present study was to evaluate the anti-tumor potential of LFs, and further explore the underlying mechanisms. Firstly, an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mouse model was established and administered with or without LFs for 10 weeks, and then the severity of CAC was examined macroscopically and histologically. Subsequently, the effects of LFs on expression of proteins associated with apoptosis and proliferation, levels of inflammatory cytokine, expression of phosphorylated-Janus kinases 2 (p-Jak2) and phosphorylated-signal transducer and activator of transcription 3 (p-Stat3), and activation of nuclear factor-κB (NFκB) and P53 were assessed. We found that LFs could significantly reduce tumorigenesis induced by AOM/DSS. Further study revealed that LFs treatment substantially reduced activation of NFκB and P53, and subsequently suppressed production of inflammatory cytokines and phosphorylation of Jak2 and Stat3 in AOM/DSS-induced mice. Taken together, LFs treatment alleviated AOM/DSS induced CAC via P53 and NFκB/IL-6/Jak2/Stat3 pathways, highlighting the potential of LFs in preventing CAC.

  2. Evaluation of Concrete Consolidation: DSS-35 Antenna Reinforced Concrete Pedestal, Canberra Deep Space Communications Complex, Australia

    Science.gov (United States)

    Saldua, B. P.; Dodge, E. C.; Kolf, P. R.; Olson, C. A.

    2016-02-01

    Antenna structures for the Deep Space Network track spacecraft that are millions of miles away. Therefore, these structures have tight specifications for translation, rotation, and differential settlement. This article presents several nondestructive test methods that were used to evaluate, locate, and repair imperfections in the reinforced concrete pedestal that supports the DSS-35 antenna structure. These methods include: (1) impulse response (IR), (2) ultrasonic shear-wave tomography (MIRA), and (3) ground-penetrating radar (GPR).

  3. An integrated information management system based DSS for problem solving and decision making in open & distance learning institutions of India

    Directory of Open Access Journals (Sweden)

    Pankaj Khanna

    2014-04-01

    Full Text Available An integrated information system based DSS is developed for Open and Distance Learning (ODL institutions in India. The system has been web structured with the most suitable newly developed modules. A DSS model has been developed for solving semi-structured and unstructured problems including decision making with regard to various programmes and activities operating in the ODLIs. The DSS model designed for problem solving is generally based on quantitative formulas, whereas for problems involving imprecision and uncertainty, a fuzzy theory based DSS is employed. The computer operated system thus developed would help the ODLI management to quickly identify programmes and activities that require immediate attention. It shall also provide guidance for obtaining the most appropriate managerial decisions without any loss of time. As a result, the various subsystems operating in the ODLI are able to administer its activities more efficiently and effectively to enhance the overall performance of the concerned ODL institution to a new level.

  4. Analysis of Payment Card Industry Data Security Standard [PCI DSS] Compliance by Confluence of COBIT 5 Framework

    Directory of Open Access Journals (Sweden)

    Ashish Ukidve

    2017-01-01

    Full Text Available The Payment Card Industry Data Security Standard (PCI DSS aims to enhance the security of cardholder data and is required when cardholder data or authentication data are stored, processed or transmitted. The implementation of enabling processes from COBIT 5 can complement compliance to PCI DSS. COBIT 5 assists enterprises in governance and management of enterprise IT and, at the same time, supports the need to meet security requirements with supporting processes and management activities. This paper provides analysis of mapping of COBIT 5 supporting processes to PCI DSS 3.0 security requirements. It also presents domains which support the simultaneous application of COBIT 5 and PCI DSS 3.0 which would help create collaborations within the enterprise

  5. Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.

    Science.gov (United States)

    Jiang, Xingwei; Yu, Jiahui; Shi, Qingzhu; Xiao, Yan; Wang, Wei; Chen, Guojiang; Zhao, Zhi; Wang, Renxi; Xiao, He; Hou, Chunmei; Feng, Jiannan; Ma, Yuanfang; Shen, Beifen; Wang, Lili; Li, Yan; Han, Gencheng

    2015-10-01

    Tim-3 is involved in the physiopathology of inflammatory bowel disease (IBD), but the underlying mechanism is unknown. Here, we demonstrated that, in mouse with DSS colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Adoptive transfer of Tim-3-silenced macrophages worsened DSS colitis and enhanced inflammation, while Tim-3 overexpression attenuated DSS colitis by decreasing the M1 macrophage response. Co-culture of Tim-3-overexpressing macrophages with intestinal lymphocytes decreased the pro-inflammatory response. Tim-3 shaped intestinal macrophage polarization may be TLR-4 dependent since Tim-3 blockade failed to exacerbate colitis or increase M1 macrophage response in the TLR-4 KO model. Finally, Tim-3 signaling inhibited phosphorylation of IRF3, a TLR-4 downstream transcriptional factor regulating macrophage polarization. A better understanding of this pathway may shed new light on colitis pathogenesis and result in a new therapeutic strategy.

  6. A New High-Frequency Search for Galactic Center Millisecond Pulsars using DSS-43

    Science.gov (United States)

    Lemley, Cameron; Prince, Thomas Allen; Majid, Walid A.; Murchikova, Elena

    2016-01-01

    The primary 70-meter Deep Space Network antenna (DSS-43) in Canberra, Australia was equipped with a new high-frequency (18-28 GHz) receiver system in May 2015 for use in a search for Galactic Center (GC) millisecond pulsars. The primary motivation for this search is that a pulsar in the Galactic Center region (especially one that is gravitationally bound to the massive black hole at the GC) would provide unprecedented tests of gravity in the strong-field regime and would offer an entirely new tool for probing the characteristics of the Galactic Center region. Preparation for the GC pulsar search has involved the development of a single-pulse search pipeline that integrates tools from both Fortran and Python as well as the implementation of this pipeline on high performance CPUs. The original version of the search pipeline was developed using Vela Pulsar data from DSS-43, and a more refined version that relies upon chi-squared fitting techniques was ultimately developed using Crab Pulsar data. Future work will involve continued testing of the single-pulse search pipeline using data from the rotating radio transient (RRAT) J1819-1458, the characterization of RRAT pulses using high time resolution data from the new receiver system on DSS-43, and ultimately the analysis of high-frequency data using the existing pipeline to search for millisecond pulsars in the Galactic Center.

  7. Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.

    Science.gov (United States)

    Nighot, Prashant; Al-Sadi, Rana; Rawat, Manmeet; Guo, Shuhong; Watterson, D Martin; Ma, Thomas

    2015-12-15

    Recent studies have implicated a pathogenic role for matrix metalloproteinases 9 (MMP-9) in inflammatory bowel disease. Although loss of epithelial barrier function has been shown to be a key pathogenic factor for the development of intestinal inflammation, the role of MMP-9 in intestinal barrier function remains unclear. The aim of this study was to investigate the role of MMP-9 in intestinal barrier function and intestinal inflammation. Wild-type (WT) and MMP-9(-/-) mice were subjected to experimental dextran sodium sulfate (DSS) colitis by administration of 3% DSS in drinking water for 7 days. The mouse colonic permeability was measured in vivo by recycling perfusion of the entire colon using fluorescently labeled dextran. The DSS-induced increase in the colonic permeability was accompanied by an increase in intestinal epithelial cell MMP-9 expression in WT mice. The DSS-induced increase in intestinal permeability and the severity of DSS colitis was found to be attenuated in MMP-9(-/-) mice. The colonic protein expression of myosin light chain kinase (MLCK) and phospho-MLC was found to be significantly increased after DSS administration in WT mice but not in MMP-9(-/-) mice. The DSS-induced increase in colonic permeability and colonic inflammation was attenuated in MLCK(-/-) mice and MLCK inhibitor ML-7-treated WT mice. The DSS-induced increase in colonic surface epithelial cell MLCK mRNA was abolished in MMP-9(-/-) mice. Lastly, increased MMP-9 protein expression was detected within the colonic surface epithelial cells in ulcerative colitis cases. These data suggest a role of MMP-9 in modulation of colonic epithelial permeability and inflammation via MLCK.

  8. UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis.

    Science.gov (United States)

    Ranganathan, Punithavathi; Jayakumar, Calpurnia; Li, Dean Y; Ramesh, Ganesan

    2014-07-01

    The netrin-1 administration or overexpression is known to protect colon from acute colitis. However, the receptor that mediates netrin-1 protective activities in the colon during colitis remains unknown. We tested the hypothesis that UNC5B receptor is a critical mediator of protective function of netrin-1 in dextran sodium sulfate (DSS)-induced colitis using mice with partial deletion of UNC5B receptor. DSS colitis was performed in mice with partial genetic UNC5B deficiency (UNC5B(+/-) mice) or wild-type mice to examine the role of endogenous UNC5B. These studies were supported by in vitro models of DSS-induced apoptosis in human colon epithelial cells. WT mice developed colitis in response to DSS feeding as indicated by reduction in bw, reduction in colon length and increase in colon weight. These changes were exacerbated in heterozygous UNC5B knockout mice treated with DSS. Periodic Acid-Schiff stained section shows damages in colon epithelium and mononuclear cell infiltration in WT mice, which was further increased in UNC5B heterozygous knockout mice. This was associated with large increase in inflammatory mediators such as cytokine and chemokine expression and extensive apoptosis of epithelial cells in heterozygous knockout mice as compared to WT mice. Overexpression of UNC5B human colon epithelial cells suppressed DSS-induced apoptosis and caspase-3 activity. Moreover, DSS induced large amount of netrin-1 and shRNA mediated knockdown of netrin-1 induction exacerbated DSS-induced epithelial cell apoptosis. Our results suggest that UNC5B is a critical mediator of cell survival in response to stress in colon.

  9. IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses.

    Science.gov (United States)

    Zhu, Junfeng; Yang, Fangli; Sang, Lixuan; Zhai, Jingbo; Zhang, Xiaoqing; Yue, Dan; Li, Shengjun; Li, Yan; Lu, Changlong; Sun, Xun

    2015-01-01

    Interleukin- (IL-) 33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated diseases. IL-33 was expressed in high level on epithelial cells of intestinal tract. It suggested that IL-33 plays a potential role in inflammatory bowel diseases (IBD). We investigated the role of interleukin- (IL-) 33 in dextran sulphate sodium- (DSS-) induced acute colitis in mice using recombinant mouse IL-33 protein (rIL-33). We found that DSS-induced acute colitis was aggravated by rIL-33 treatment. rIL-33-treated DSS mice showed markedly reduced levels of interferon- (IFN-)γ and IL-17A in their colon lamina propria lymphocytes (LPL), but the levels of Th2 cytokines, such as IL-5 and IL-13, in these cells were significantly increased, compared to DSS mice treated with PBS. Our results suggested that IL-33 stimulated CD4(+)T cells and caused the cell to adopt a Th2-type response but at the same time suppressed Th17 and Th1 cell responses. Therefore, IL-33 may be involved in pathogenesis of DSS-induced acute colitis by promoting Th2 cell response in intestinal mucosa of mice. Modulation of IL-33/ST2 signaling by monoclonal antibody (mAb) could be a novel biological therapy in DSS-induced acute colitis.

  10. Decision Support System Research and Development Network for Agricultural and Natural Resource Management in Thailand: A TRF-DSS Experience

    Directory of Open Access Journals (Sweden)

    Thaworn Onpraphai

    2012-04-01

    Full Text Available This paper aims to introduce the Decision Support System (DSS, which is an area informatics approach to area studies, and the research network complex based on DSS’s application in Thailand. In particular, the paper presents and discusses current activities of the DSS research network at the national level in Thailand rather than being a theoretical and analytical study of the DSS mechanism or its cases. DSS has wide applications in Thailand, extending to various fields such as agricultural and natural resource management, economic and social management, historical and cultural preservation, and so on. DSS generally refers to a support system embedded into a computer system for providing intellectual resources with the appropriate numerical model necessary for decision making in production activities. Agricultural and natural resources have been the foundation of social and economic development in Thailand since the country’s first national plan in the 1960s. Decision making to maintain agricultural productivity as well as to protect natural resources requires well-integrated data sets. The Thailand Research Fund (TRF established a DSS research and development network (TRF-DSS in 2002 to help various research teams in Thailand develop DSS tools and components for addressing agricultural and natural resource management issues. Using a “systems” approach, the DSS framework allows researchers and users to identify and integrate key components as well as to define databases and model-base management systems. This paper focuses on the TRF-DSS research and development network, which consists of 12 universities, two line agencies in Thailand, and a line agency in Cambodia. During 2002–10, a total of 59 research projects were granted a budget allocation of 140.1 million baht, and a budget of 15.4 million baht was allocated to support activities of the network. In addition, 10 projects were funded to carry out postproject activities, with a

  11. Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages.

    Science.gov (United States)

    Ke, Ping; Shao, Bo-Zong; Xu, Zhe-Qi; Wei, Wei; Han, Bin-Ze; Chen, Xiong-Wen; Su, Ding-Feng; Liu, Chong

    2016-01-01

    Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying mechanism remains unclear. In the present study, we examined whether activation of CB2R could suppress the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. In peritoneal macrophages isolated from C57BL/6 mice, LPS/DSS challenge for 24 h increased the expression of the components of NLRP3 inflammasome NLRP3, Casp-1 p20/Casp-1 p45 ratio, proIL-1β and IL-1β and also enhanced autophagy (LC3-II/LC3-I ratio, Beclin-1 and SQSTM1). Pretreatment of peritoneal macrophages with HU 308, a selective CB2R agonist, attenuated LPS/DSS-induced NLRP3 inflammasome activation, but further enhanced autophagy. In comparison with wild-type (WT) control, peritoneal macrophages from CB2R knockout (KO) mice had more robust NLRP3 inflammasome activation and attenuated autophagy upon LPS/DSS challenge. Knockdown autophagy-related gene 5 (Atg5) with a siRNA in peritoneal macrophages attenuated the inhibitory effects of HU 308 on LPS/DSS-induced NLRP3 inflammasome activation in vitro. In vivo, HU308 treatment attenuated DSS-induced colitis mice associated with reduced colon inflammation and inhibited NLRP3 inflammasome activation in wild-type mice. In CB2R KO mice, DSS-induced inflammation and NLRP3 inflammasome activation were more pronounced than those in WT control. Finally, we demonstrated that AMPK-mTOR-P70S6K signaling pathway was involved in this CB2R-mediated process. We conclude that activation of CB2R ameliorates DSS-induced colitis through enhancing autophagy that may inhibit NLRP3 inflammasome activation in macrophages.

  12. The western South China Sea currents from measurements by Argo profiling floats during October to December 2007

    Institute of Scientific and Technical Information of China (English)

    周慧; 袁东亮; 李瑞祥; 何蕾

    2010-01-01

    The three dimensional structure of the western boundary current east of the Vietnam coast was determined from measurements by Argo profiling floats which deployed near the east of the Vietnam Coast in October 2007. The trajectories of the Argo floats provided robust evidence that there does exist southward flowing current along the Vietnam coast. The southward current begins at about 15°N, 111°E, flowing along the 1 000 m isobath and extending to 5°N south. The estimated surface and parking depth velocities...

  13. Argo data assimilation into HYCOM with an EnOI method in the Atlantic Ocean

    Science.gov (United States)

    Mignac, D.; Tanajura, C. A. S.; Santana, A. N.; Lima, L. N.; Xie, J.

    2015-02-01

    An ocean data assimilation system to assimilate Argo temperature (T) and salinity (S) profiles into the HYbrid Coordinate Ocean Model (HYCOM) was constructed, implemented and evaluated for the first time in the Atlantic Ocean (78° S to 50° N and 98° W to 20° E). The system is based on the ensemble optimal interpolation (EnOI) algorithm proposed by Xie and Zhu (2010), especially made to deal with the hybrid nature of the HYCOM vertical coordinate system with multiple steps. The Argo T-S profiles were projected to the model vertical space to create pseudo-observed layer thicknesses (Δ pobs), which correspond to the model target densities. The first step was to assimilate Δ pobs considering the sub-state vector composed by the model layer thickness (Δ p) and the baroclinic velocity components. After that, T and S were assimilated separately. Finally, T was diagnosed below the mixed layer to preserve the density of the model isopycnal layers. Five experiments were performed from 1 January 2010 to 31 December 2012: a control run without assimilation, and four assimilation runs considering the different vertical localizations of T, S and Δ p. The assimilation experiments were able to significantly improve the thermohaline structure produced by the control run. They reduced the root mean square deviation (RMSD) of T and S calculated with respect to Argo independent data in 34 and 44%, respectively, in comparison to the control run. In some regions, such as the western North Atlantic, substantial corrections in the 20 °C isotherm depth and the upper ocean heat content towards climatological states were achieved. The runs with a vertical localization of Δ p showed positive impacts in the correction of the thermohaline structure and reduced the RMSD of T (S) from 0.993 °C (0.149 psu) to 0.905 °C (0.138 psu) for the whole domain with respect to the other assimilation runs.

  14. Mapping error in Southern Ocean transport computed from satellite altimetry and argo

    Science.gov (United States)

    Kosempa, Michael; Chambers, Don P.

    2016-11-01

    In an effort to better estimate transport dynamics in response to wind forcing (primarily the Southern Annual Mode), this study quantifies the uncertainty in mapping zonal geostrophic transport of the Antarctic Circumpolar Current from sparse temperature, salinity and sea surface height observations. To do this, we sampled an ocean state estimate at the locations of both Argo floats and the Jason-1 altimeter groundtrack. These sampled values were then optimally interpolated to create SSH and temperature/salinity grids with 1° resolution. The temperature, salinity and SSH grids were then combined to compute the zonal geostrophic transport and compared to that estimated from the full state estimate. There are significant correlations between the baroclinic and barotropic error contributions to the total transport error. The increase in Argo floats in the Southern Ocean is effective in reducing mapping error. However, that error improvement is not uniform. By analyzing systematic errors in transport time series, we find the transects that are most appropriate for analyzing the dynamics of ACC transport using Argo and altimetric gridded fields. Based on our analysis, we conclude region south of Tasmania is most appropriate, with lowest uncertainty. Using real-world data, we calculated zonal transport variability at a transect south of Tasmania. There is an insignificant trend (0.3 ± 0.4 Sv yr-1, 90% confidence) but significant low-frequency variability correlated with the Southern Annular Mode (0.53, p < 0.05). The barotropic component is most responsible for the low-frequency variability, and this would be unobservable from ship casts without velocity measurements at depth.

  15. An argo-based model for investigation of the Global Ocean (AMIGO)

    Science.gov (United States)

    Lebedev, K. V.

    2016-03-01

    We analyze the newly developed Argo-Based Model for Investigation of the Global Ocean (AMIGO), which consists of a block for variational interpolation of the profiles of drifting Argo floats to a regular grid and a block for model hydrodynamic adjustment of variationally interpolated fields. Such a method makes it possible to obtain a full set of oceanographic characteristics—temperature, salinity, density, and current velocity—using irregularly located Argo measurements. The resulting simulations are represented as monthly mean, seasonal, and annual means and climatological fields. The AMIGO oceanographic database developed at the Shirshov Institute of Oceanology from model simulations covers the 10-year period from 2005 to 2014. Analysis of transport variations in the propagation of North Atlantic Current jets to the Arctic based on the AMIGO data showed that during this period, anomalous winter transports were observed, which correlate with anomalous winter temperatures in regions of northwestern Europe, northern European Russia, and Iceland, which are subjected to the influence of these currents. Comparative analysis of variations in mass and heat transport by the currents and the North Atlantic Oscillation (NAO) index in the period of 2005-2014 shows a well pronounced correlation between them. The low winter values of the NAO index correspond to the low values of winter transports by the Faroe-Shetland branch of the North Atlantic current, and usually, to the high values of winter transports by the North Icelandic branch of the Irminger Current. High winter value of the NAO index results in a substantial increase in the winter transport by the Faroe-Shetland branch of the North Atlantic Current without notable influence on the transport of the North Icelandic branch of the Irminger Current.

  16. The ARGOS laser system: green light for ground layer adaptive optics at the LBT

    Science.gov (United States)

    Raab, Walfried; Rabien, Sebastian; Gässler, Wolfgang; Esposito, Simone; Barl, Lothar; Borelli, Jose; Daysenroth, Matthias; Gemperlein, Hans; Kulas, Martin; Ziegleder, Julian

    2014-07-01

    We report on the development of the laser system of ARGOS, the multiple laser guide star adaptive optics system for the Large Binocular Telescope (LBT). The system uses a total of six high powered, pulsed Nd:YAG lasers frequency-doubled to a wavelength of 532 nm to generate a set of three guide stars above each of the LBT telescopes. The position of each of the LGS constellations on sky as well as the relative position of the individual laser guide stars within this constellation is controlled by a set of steerable mirrors and a fast tip-tilt mirror within the laser system. The entire opto-mechanical system is housed in two hermetically sealed and thermally controlled enclosures on the SX and DX side of the LBT telescope. The laser beams are propagated through two refractive launch telescopes which focus the beams at an altitude of 12 km, creating a constellation of laser guide stars around a 4 arcminute diameter circle by means of Rayleigh scattering. In addition to the GLAO Rayleigh beacon system, ARGOS has also been designed for a possible future upgrade with a hybrid sodium laser - Rayleigh beacon combination, enabling diffraction limited operation. The ARGOS laser system was successfully installed at the LBT in April 2013. Extensive functional tests have been carried out and have verified the operation of the systems according to specifications. The alignment of the laser system with respect to the launch telescope was carried out during two more runs in June and October 2013, followed by the first propagation of laser light on sky in November 2013.

  17. Virtual Visit to the ATLAS Control Room by High schools of Argos prefecture

    CERN Multimedia

    2014-01-01

    Continuing the subatomic journey that started last year in Argos, Greece, 45 students from 14 high schools of the prefecture will take part in a dedicated ATLAS Masterclass organized by the University of Athens in the framework of the Go-Lab and Inspiring Science Education European projects. Students will learn how to analyse real events from the ATLAS experiment with the use of HYPATIA online applet. They will also have the opportunity to visit the ATLAS control room to learn what it takes for scientists to keep on pushing the boundaries of our understanding of the origins of the universe.

  18. Argo: A Time-Elastic Time-Division-Multiplexed NOC using Asynchronous Routers

    DEFF Research Database (Denmark)

    Kasapaki, Evangelia; Sparsø, Jens

    2014-01-01

    In this paper we explore the use of asynchronous routers in a time-division-multiplexed (TDM) network-on-chip (NOC), Argo, that is being developed for a multi-processor platform for hard real-time systems. TDM inherently requires a common time reference, and existing TDM-based NOC designs...... are either synchronous or mesochronous. We use asynchronous routers to achieve a simpler, smaller, and more robust, self-timed design. Our design exploits the fact that pipelined asynchronous circuits also behave as ripple FIFOs. Thus, it avoids the need for explicit synchronization FIFOs between the routers...

  19. Recent Results from ArgoNeuT and Status of MicroBooNE

    Energy Technology Data Exchange (ETDEWEB)

    Szelc, Andrzej [Yale

    2015-07-10

    Liquid Argon Time Projection Chamber (LArTPC) detectors hold the key to answering the outstanding questions about the role of neutrinos in the Standard Model of Particle physics and beyond. Their fine granularity combined with calorimetric capabilities allows for precision measurements that answering these questions will require. Here, we discuss the recent results from the ArgoNeuT experiment as well as the status and prospects for MicroBooNE, both a part of the US-based LArTPC neutrino program.

  20. Generació automàtica de codi Java amb ArgoUML

    OpenAIRE

    2007-01-01

    Aquesta memòria presenta un estudi de la generació automàtica de codi Java a partir de diagrames UML amb l'eina ArgoUML. El cicle de vida tradicional del programari presenta alguns problemes com la manca de sincronització entre codi i documentació, poca portabilitat i problemes de interoperabilidad. El paradigma MDA vol solucionar en part aquests problemes fent dels models el centre del desenvolupament del programari i apostant per la generació automàtica de models i codi. Esta memoria pre...

  1. Mean Interplanetary Magnetic Field Measurement Using the ARGO-YBJ Experiment

    CERN Document Server

    Aielli, G; Bartoli, B; Bernardini, P; Bi, X J; Bleve, C; Branchini, P; Budano, A; Bussino, S; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cappa, A; Cardarelli, R; Catalanotti, S; Cattaneo, C; Celio, P; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; De Vincenzi, M; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Z Y; Feng, Zhenyong; Galeazzi, F; Galeotti, P; Gargana, R; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liberti, B; Liguori, G; Liu, C; Liu, C Q; Liu, M Y; Liu, J; Lu, H; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Meng, X R; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Perrone, L; Pistilli, P; Qu, X B; Rossi, E; Ruggieri, F; Saggese, L; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Yao, Z G; Xu, B; Xue, L; Yan, Y X; Yang, Q Y; Yang, X C; Yuan, A F; Zha, M; Zhang, H M; Zhang, JiLong; Zhang, JianLi; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhaxisangzhu,; Zhaxiciren,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2011-01-01

    The sun blocks cosmic ray particles from outside the solar system, forming a detectable shadow in the sky map of cosmic rays detected by the ARGO-YBJ experiment in Tibet. Because the cosmic ray particles are positive charged, the magnetic field between the sun and the earth deflects them from straight trajectories and results in a shift of the shadow from the true location of the sun. Here we show that the shift measures the intensity of the field which is transported by the solar wind from the sun to the earth.

  2. Fermented milk containing Lactobacillus GG alleviated DSS-induced colitis in mice and activated epidermal growth factor receptor and Akt signaling in intestinal epithelial cells

    Directory of Open Access Journals (Sweden)

    Kazutoyo Yoda

    2012-06-01

    Full Text Available Lactobacillus rhamnosus GG was assessed for its ability to alleviate DSS-induced colitis in mice and activate epidermal growth factor receptor and Akt signaling in intestinal epithelial cells. In this study mice were treated with DSS to induce colitis and they were given Lactobacillus GG fermented milk to assess the effect of probiotic on colitis. Lactobacillus GG fermented milk significantly reduced the colitis associated changes suggesting a protective effect against DSS induced colitis.

  3. Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming.

    Science.gov (United States)

    Liu, Jing; Xiao, Hai-Tao; Wang, Hong-Sheng; Mu, Huai-Xue; Zhao, Ling; Du, Jun; Yang, Depo; Wang, Dongmei; Bian, Zhao-Xiang; Lin, Shu-Hai

    2016-06-21

    Hypoxia and inflammation have been identified as the hallmarks of colitis, intertwined with metabolism. Here, we report that halofuginone (HF), an antiparasitic drug, attenuates dextran sulfate sodium (DSS)-induced colitis in mice, as represented by attenuating the disease activity index, inhibiting colonic shortening, ameliorating colonic lesions and histological signs of damage, reducing colonic myeloperoxidase activity, and suppressing the production of pro-inflammatory cytokines in colon tissue. Intriguingly, the hypoxia-inducible factor 1alpha (HIF-1α) and tumor necrosis factor alpha were also suppressed by HF treatment in colon tissues, exhibiting a tissue-specific effect. To further reveal the metabolic signatures upon HF treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in liver, spleen and colon tissues was performed. As a result, we found that HF treatment counteracted the levels of acylcarnitines, including palmitoyl-l-carnitine, isobutyrylcarnitine, vaccenylcarnitine, and myristoylcarnitine, in colon tissues with DSS induction, but no significant change in the levels of acylcarnitines was observed in liver or spleen tissues. The metabolic signatures may indicate that incomplete fatty acid oxidation (FAO) in the colon could be restored upon HF treatment as the tissue-specific metabolic characterization. Taken together, our findings uncovered that the HF potentiated anti-inflammatory effect in DSS-induced colitis in mice and its underlying mechanisms could be associated with the inhibition of HIF-1α and reduced levels of acylcarnitines, suggesting that both the inhibition of HIF-1α and the counteraction of incomplete FAO might be useful in the prevention and treatment of inflammatory bowel disease.

  4. The impact of Ag nanoparticles on the parameters of DSS- cells sensitized by Z907

    Science.gov (United States)

    Ibrayev, N. Kh; Aimukhanov, A. K.; Zeinidenov, A. K.

    2016-02-01

    Research of influence of Ag nanoparticles are in-process undertaken on absorption and on parameters CVC DSS-cells sensitized Z907. It is set that with the height of concentration Ag nanoparticles in tape to the concentration of 0.3% wt%. the absorbance of Z907 in a short-wave stripe grew to the value 1,6. It is set that under reaching the concentration of Ag nanoparticles in the cell of value the 0.3% wt%. efficiency of cell increased to 2.2%.

  5. Microhardness changes gradient of the duplex stainless steel (DSS surface layer after dry turning

    Directory of Open Access Journals (Sweden)

    G. Krolczyk

    2014-10-01

    Full Text Available The article presents the gradient of microhardness changes as a function of the distance from the material surface after turning with a wedge provided with a coating with a ceramic intermediate layer. The investigation comprised the influence of cutting speed on surface integrity microhardness in dry machining. The tested material was duplex stainless steel (DSS with two-phase, ferritic-austenitic structure. The tests have been performed under production conditions during machining of parts for electric motors and deep-well pumps.

  6. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats.

    Directory of Open Access Journals (Sweden)

    Olof Schreiber

    Full Text Available AIM: To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. METHODS: Colitis was induced with 5% DSS in drinking water for 8 days prior to experiment, when the descending colonic mucosa of anesthetized rats was studied using intravital microscopy. Mucus thickness was measured with micropipettes attached to a micromanipulator. To assess the contributions of NOS and prostaglandins in the regulation of colonic mucus thickness, the non-selective NOS-inhibitor L-NNA (10 mg/kg bolus followed by 3 mg/kg/h, the selective iNOS-inhibitor L-NIL (10 mg/kg bolus followed by 3 mg/kg/h and the non-selective COX-inhibitor diclofenac (5 mg/kg were administered intravenously prior to experiment. To further investigate the role of iNOS in the regulation of colonic mucus thickness, iNOS -/- mice were used. RESULTS: Colitic rats had a thicker firmly adherent mucus layer following 8 days of DSS treatment than untreated rats (88±2 µm vs 76±1 µm. During induction of colitis, the thickness of the colonic mucus layer initially decreased but was from day 3 significantly thicker than in untreated rats. Diclofenac reduced the mucus thickness similarly in colitic and untreated rats (-16±5 µm vs -14±2 µm. While L-NNA had no effect on colonic mucus thickness in DSS or untreated controls (+3±2 µm vs +3±1 µm, L-NIL reduced the mucus thickness significantly more in colitic rats than in controls (-33±4 µm vs -10±3 µm. The importance of iNOS in regulating the colonic mucus thickness was confirmed in iNOS-/- mice, which had thinner colonic mucus than wild-type mice (35±3 µm vs 50±2 µm, respectively. Furthermore, immunohistochemistry revealed increased levels of iNOS in the colonic surface epithelium following DSS treatment. CONCLUSION: Both prostaglandins and nitric oxide regulate basal colonic mucus thickness. During onset of colitis, the thickness of the mucus layer is initially reduced followed by an i

  7. Dextran sodium sulfate (DSS induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon.

    Directory of Open Access Journals (Sweden)

    Hamed Laroui

    Full Text Available Inflammatory bowel diseases (IBDs, primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal inflammation. In addition, no DSS-associated molecule (free glucose, sodium sulfate solution, free dextran induces in vitro or in vivo intestinal inflammation. We find that DSS but not dextran associated molecules established linkages with medium-chain-length fatty acids (MCFAs, such as dodecanoate, that are present in the colonic lumen. DSS complexed to MCFAs forms nanometer-sized vesicles ~200 nm in diameter that can fuse with colonocyte membranes. The arrival of nanometer-sized DSS/MCFA vesicles in the cytoplasm may activate intestinal inflammatory signaling pathways. We also show that the inflammatory activity of DSS is mediated by the dextran moieties. The deleterious effect of DSS is localized principally in the distal colon, therefore it will be important to chemically modify DSS to develop materials beneficial to the colon without affecting colon-targeting specificity.

  8. Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice.

    Science.gov (United States)

    Zhao, Hongyu; Yan, Rui; Zhou, Xiaogang; Ji, Fang; Zhang, Bing

    2016-10-01

    Intestinal barrier involves in the pathogeny of inflammatory bowel disease (IBD) and hydrogen sulfide (H2S) has been reported to improve intestinal barrier integrity. Thus, this study investigated the effects of GYY4137, a slow-release H2S donor, on DSS-induced inflammation and intestinal dysfunction. In vitro model, cellular permeability was significantly increased and expression of tight junctions (ZO-1, Cauldin4, and Occludin) was downregulated in Caco-2 cells. GYY4137 treatment markedly attenuated DSS-induced inflammation and barrier dysfunction. Cystathionine β-synthase (CBS)-siRNA transfection further demonstrated that endogenous H2S system involves in DSS-induced inflammation and mediates barrier function. In vivo model, DSS exposure caused colonic inflammation and injury in mice and GYY4137 injection alleviated inflammatory response and improved intestinal barrier via reducing intestinal permeability and upregulating of tight junctions. In conclusion, endogenous H2S system involves in DSS-induced inflammation and H2S addition alleviated inflammation and intestinal dysfunction in vitro and in vivo.

  9. Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis.

    Science.gov (United States)

    He, Xuexiu; Wei, Zhengkai; Wang, Jingjing; Kou, Jinhua; Liu, Weijian; Fu, Yunhe; Yang, Zhengtao

    2016-06-20

    Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. However, the effect of alpinetin on inflammatory bowel disease (IBD) has not yet been reported. The purpose of this study was to investigate the anti-inflammatory effect and mechanism of alpinetin on dextran sulfate sodium (DSS)-induced colitis in mice. In vivo, DSS-induced mice colitis model was established by giving mice drinking water containing 5% (w/v) DSS for 7 days. Alpinetin (25, 50 and 100 mg/kg) were administered once a day by intraperitoneal injection 3 days before DSS treatment. In vitro, phorbol myristate acetate (PMA)-differentiated monocytic THP-1 macrophages were treated with alpinetin and stimulated by lipopolysaccharide (LPS). The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-α) and interleukin (IL-1β) production in mice. In vitro, alpinetin markedly inhibited LPS-induced TNF-α and IL-1β production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-κB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation. In conclusion, this study demonstrated that alpinetin had protective effects on DSS-induced colitis and may be a promising therapeutic reagent for colitis treatment.

  10. Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium.

    Science.gov (United States)

    Zhang, Qianpeng; Wu, Yanqiu; Wang, Jing; Wu, Guojun; Long, Wenmin; Xue, Zhengsheng; Wang, Linghua; Zhang, Xiaojun; Pang, Xiaoyan; Zhao, Yufeng; Zhao, Liping; Zhang, Chenhong

    2016-06-06

    Butyrate-producing bacteria (BPB) are potential probiotic candidates for inflammatory bowel diseases as they are often depleted in the diseased gut microbiota. However, here we found that augmentation of a human-derived butyrate-producing strain, Anaerostipes hadrus BPB5, significantly aggravated colitis in dextran sulphate sodium (DSS)-treated mice while exerted no detrimental effect in healthy mice. We explored how the interaction between BPB5 and gut microbiota may contribute to this differential impact on the hosts. Butyrate production and severity of colitis were assessed in both healthy and DSS-treated mice, and gut microbiota structural changes were analysed using high-throughput sequencing. BPB5-inoculated healthy mice showed no signs of colitis, but increased butyrate content in the gut. In DSS-treated mice, BPB5 augmentation did not increase butyrate content, but induced significantly more severe disease activity index and much higher mortality. BPB5 didn't induce significant changes of gut microbiota in healthy hosts, but expedited the structural shifts 3 days earlier toward the disease phase in BPB5-augmented than DSS-treated animals. The differential response of gut microbiota in healthy and DSS-treated mice to the same potentially beneficial bacterium with drastically different health consequences suggest that animals with dysbiotic gut microbiota should also be employed for the safety assessment of probiotic candidates.

  11. Design and implementation of a beam-waveguide mirror control system for vernier pointing of the DSS-13 antenna

    Science.gov (United States)

    Alvarez, L. S.; Moore, M.; Veruttipong, W.; Andres, E.

    1994-01-01

    The design and implementation of an antenna beam-waveguide (BWG) mirror position control system at the DSS-13 34-m antenna is presented. While it has several potential applications, a positioner on the last flat-plate BWG mirror (M6) at DSS 13 is installed to demonstrate the conical scan (conscan) angle-tracking technique at the Ka-band (32-GHz) operating frequency. Radio frequency (RF) beam-scanning predictions for the M6 mirror, computed from a diffraction analysis, are presented. From these predictions, position control system requirements are then derived. The final mechanical positioner and servo system designs, as implemented at DSS 13, are illustrated with detailed design descriptions given in the appendices. Preliminary measurements of antenna Ka-band beam scan versus M6 mirror tilt made at DSS 13 in December 1993 are presented. After reduction, the initial measurements are shown to be in agreement with the RF predicts. Plans for preliminary conscan experimentation at DSS 13 are summarized.

  12. A calibration method of Argo floats based on multiple regression analysis

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Argo floats are free-moving floats that report vertical profiles of salinity, temperature and pressure at regular time intervals. These floats give good measurements of temperature and pressure, but salinity measurements may show significant sensor drifting with time. It is found that sensor drifting with time is not purely linear as presupposed by Wong (2003). A new method is developed to calibrate conductivity data measured by Argo floats. In this method, Wong's objective analysis method was adopted to estimate the background climatological salinity field on potential temperature surfaces from nearby historical data in WOD01. Furthermore, temperature and time factors are taken into account, and stepwise regression was used for a time-varying or temperature-varying slope in potential conductivity space to correct the drifting in these profiling float salinity data. The result shows salinity errors using this method are smaller than that of Wong's method, the quantitative and qualitative analysis of the conductivity sensor can be carried out with our method.

  13. The analog Resistive Plate Chamber detector of the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari1, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini1, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q

    2015-01-01

    The ARGO-YBJ experiment has been in stable data taking from November 2007 till February 2013 at the YangBaJing Cosmic Ray Observatory (4300 m a.s.l.). The detector consists of a single layer of Resistive Plate Chambers (RPCs) ( about 6700 m^2}) operated in streamer mode. The signal pick-up is obtained by means of strips facing one side of the gas volume. The digital readout of the signals, while allows a high space-time resolution in the shower front reconstruction, limits the measurable energy to a few hundred TeV. In order to fully investigate the 1-10 PeV region, an analog readout has been implemented by instrumenting each RPC with two large size electrodes facing the other side of the gas volume. Since December 2009 the RPC charge readout has been in operation on the entire central carpet (about 5800 m^2). In this configuration the detector is able to measure the particle density at the core position where it ranges from tens to many thousands of particles per m^2. Thus ARGO-YBJ provides a highly detailed...

  14. Pre-shipment test of the ARGOS laser guide star wavefront sensor

    Science.gov (United States)

    Bonaglia, Marco; Busoni, Lorenzo; Mazzoni, Tommaso; Puglisi, Alfio; Antichi, Jacopo; Esposito, Simone; Orban de Xivry, Gilles; Rabien, Sebastian

    2014-08-01

    We present the results of the laboratory characterization of the ARGOS LGS wavefront sensor (LGSW) and dichroic units. ARGOS is the laser guide star adaptive optics system of the Large Binocular Telescope (LBT). It implements a Ground Layer Adaptive Optics (GLAO) correction for LUCI, an infrared imager and multi-object spectrograph (MOS), using 3 pulsed Rayleigh beacons focused at 12km altitude. The LGSW is a Shack-Hartman sensor having 15 × 15 subaspertures over the telescope pupil. Each LGS is independently stabilized for on-sky jitter and gated to reduce spot elongation. The 3 LGS pupils are stabilized to compensate mechanical flexure and are arranged on a single detector. Two units of LGSW have been produced and tested at Arcetri Observatory. We report on the results obtained in the pre-shipment laboratory test: internal active flexure compensation loop performance, optomechanical stability under different gravity conditions, thermal cycling, Pockels cells performance. We also update on the upcoming installation and commissioning campaign at LBT.

  15. From satellite altimetry to operational oceanography and Argo: three revolutions in oceanography (Fridtjof Nansen Medal Lecture)

    Science.gov (United States)

    Le Traon, P. Y.

    2012-04-01

    The launch of the US/French mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large scale sea level and ocean circulation observations was flying. Topex/Poseidon revolutionized our vision and understanding of the ocean. It provided new views of the large scale seasonal and interannual sea level and ocean circulation variations. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. The ERS-1/2 orbit was well adapted for mesoscale circulation sampling but the orbit determination and altimeter performance were much less precise than for T/P. We demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. This was an essential first step for the merging of T/P and ERS-1/2. The second step required the development of a global optimal interpolation method. Near real time high resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 years. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. The unique capability of satellite altimetry to observe the global ocean in near real time at high resolution was essential to the development of global ocean forecasting, a second revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) (1998-2008) was phased with the T/P and ERS-1/2 successors (Jason-1 and ENVISAT) and was instrumental in the development of global operational oceanography capabilities. Europe played a leading role in GODAE. In 1998, the global in-situ observing system was inadequate for the global scope of GODAE. This led to the development of Argo, an

  16. Ammonite biostratigraphy of the uppermost Tithonian, Berriasian, and lower Valanginian along the Río Argos (Caravaca, SE Spain)

    NARCIS (Netherlands)

    Hoedemaeker, P.J.

    1982-01-01

    This paper deals with the ammonite biostratigraphy of the lower 312 m of the Miravetes Formation (sections Y and Z) exposed 500 m north and northwest of Los Miravetes along the Río Argos, 3 km west of Caravaca (SE Spain). This sequence embraces the uppermost Tithonian, Berriasian, and lower Valangin

  17. Small Berriasian, lower Valanginian and Barremian heteromorphic ammonites from the Río Argos succession (Caravaca, southeast Spain)

    NARCIS (Netherlands)

    Vasícek, V; Hoedemaeker, P.J.

    2003-01-01

    The small heteromorphic ammonites from the Berriasian, lower Valanginian and Barremian strata of the Río Argos succession (west of Caravaca, southeast Spain) are described. One new genus is introduced, Sabaudiella (type species Ancyloceras sabaudianum Pictet & de Loriol, 1858), and three new species

  18. Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice.

    Science.gov (United States)

    Wang, Yungang; Tian, Jie; Tang, Xinyi; Rui, Ke; Tian, Xinyu; Ma, Jie; Ma, Bin; Xu, Huaxi; Lu, Liwei; Wang, Shengjun

    2016-03-29

    Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel disease (IBD), but their role in the disease remains controversial. We sought to define the effect of granulocytic MDSC-derived exosomes (G-MDSC exo) in dextran sulphate sodium (DSS)-induced murine colitis. G-MDSC exo-treated mice showed greater resistance to colitis, as reflected by lower disease activity index, decreased inflammatory cell infiltration damage. There was a decrease in the proportion of Th1 cells and an increase in the proportion of regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) from G-MDSC exo-treated colitis mice. Moreover, lower serum levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α were detected in G-MDSC exo-treated colitis mice. Interestingly, inhibition of arginase (Arg)-1 activity in G-MDSC exo partially abrogated the spontaneous improvement of colitis. In addition, G-MDSC exo could suppress CD4+ T cell proliferation and IFN-γ secretion in vitro and inhibit the delayed-type hypersensitivity (DTH) response, and these abilities were associated with Arg-1 activity. Moreover, G-MDSC exo promoted the expansion of Tregs in vitro. Taken together, these results suggest that G-MDSC exo attenuate DSS-induced colitis through inhibiting Th1 cells proliferation and promoting Tregs expansion.

  19. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation.

    Science.gov (United States)

    Heinsbroek, Sigrid E M; Williams, David L; Welting, Olaf; Meijer, Sybren L; Gordon, Siamon; de Jonge, Wouter J

    2015-12-01

    β-Glucans have beneficial health effects due to their immune modulatory properties. Oral administration of β-glucans affects tumour growth, microbial infection, sepsis, and wound healing. We hypothesized that pre-treatment with orally delivered soluble and particulate β-glucans could ameliorate the development of aggravate dextran sulfate sodium (DSS) induced intestinal inflammation. To study this, mice were orally pre-treated with β-glucans for 14 days. We tested curdlan (a particulate β-(1,3)-glucan), glucan phosphate (a soluble β-(1,3)-glucan), and zymosan (a particle made from Saccharomyces cerevisiae, which contains around 55% β-glucans). Weight loss, colon weight, and feces score did not differ between β-glucan and vehicle treated groups. However, histology scores indicated that β-glucan-treated mice had increased inflammation at a microscopic level suggesting that β-glucan treatment worsened intestinal inflammation. Furthermore, curdlan and zymosan treatment led to increased colonic levels of inflammatory cytokines and chemokines, compared to vehicle. Glucan phosphate treatment did not significantly affect cytokine and chemokine levels. These data suggest that particulate and soluble β-glucans differentially affect the intestinal immune responses. However, no significant differences in other clinical colitis scores between soluble and particulate β-glucans were found in this study. In summary, β-glucans aggravate the course of dextran sulfate sodium (DSS)-induced intestinal inflammation at the level of the mucosa.

  20. Determinants of fertility in rural Ethiopia: the case of Butajira Demographic Surveillance System (DSS

    Directory of Open Access Journals (Sweden)

    Worku Alemayehu

    2011-10-01

    Full Text Available Abstract Background Fertility is high in rural Ethiopia. Women in the reproductive age group differed in various characteristics including access to food and encounter to drought which requisite the assessment of determinants of fertility. Methods Reproductive age women were recruited from a DSS, the Butajira DSS database. A DHS maternity history questionnaire was administered on 9996 participants. Data quality was assured besides ethical clearance. Poisson regression crude and adjusted Incidence Rate Ratio with 95 Confidence Interval were used to identify determinants of fertility. Results Delayed marriage, higher education, smaller family, absence of child death experience and living in food-secured households were associated with small number of children. Fertility was significantly higher among women with no child sex preference. However, migration status of women was not statistically significant. Conclusions Policy makers should focus on hoisting women secondary school enrollment and age at first marriage. The community should also be made aware on the negative impact of fertility on household economy, environmental degradation and the country's socio-economic development at large.

  1. BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.

    Science.gov (United States)

    Yukitake, Hiroshi; Kimura, Haruhide; Suzuki, Hirobumi; Tajima, Yasukazu; Sato, Yoshimi; Imaeda, Toshihiro; Kajino, Masahiro; Takizawa, Masayuki

    2011-01-01

    Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that are primarily represented by ulcerative colitis and Crohn's disease. The etiology of IBD is not well understood; however, oxidative stress is considered a potential etiological and/or triggering factor for IBD. We have recently reported the identification of BTZO-1, an activator of antioxidant response element (ARE)-mediated gene expression, which protects cardiomyocytes from oxidative stress-induced insults. Here we describe the potential of BTZO-15, an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, for the treatment of IBD. BTZO-15 induced expression of heme oxygenase-1 (HO-1), an ARE-regulated cytoprotective protein, and inhibited NO-induced cell death in IEC-18 cells. Large intestine shortening, rectum weight gain, diarrhea, intestinal bleeding, and an increase in rectal myeloperoxidase (MPO) activity were observed in a dextran sulfate sodium (DSS)-induced colitis rat model. Oral administration of BTZO-15 induced HO-1 expression in the rectum and attenuated DSS-induced changes. Furthermore BTZO-15 reduced the ulcerated area and rectal MPO activity in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats without affecting rectal TNF-α levels. These results suggest that BTZO-15 is a promising compound for a novel IBD therapeutic drug with ARE activation properties.

  2. BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yukitake

    Full Text Available Inflammatory bowel disease (IBD is a group of chronic inflammatory disorders that are primarily represented by ulcerative colitis and Crohn's disease. The etiology of IBD is not well understood; however, oxidative stress is considered a potential etiological and/or triggering factor for IBD. We have recently reported the identification of BTZO-1, an activator of antioxidant response element (ARE-mediated gene expression, which protects cardiomyocytes from oxidative stress-induced insults. Here we describe the potential of BTZO-15, an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, for the treatment of IBD. BTZO-15 induced expression of heme oxygenase-1 (HO-1, an ARE-regulated cytoprotective protein, and inhibited NO-induced cell death in IEC-18 cells. Large intestine shortening, rectum weight gain, diarrhea, intestinal bleeding, and an increase in rectal myeloperoxidase (MPO activity were observed in a dextran sulfate sodium (DSS-induced colitis rat model. Oral administration of BTZO-15 induced HO-1 expression in the rectum and attenuated DSS-induced changes. Furthermore BTZO-15 reduced the ulcerated area and rectal MPO activity in 2,4,6-trinitrobenzene sulfonic acid (TNBS-induced colitis rats without affecting rectal TNF-α levels. These results suggest that BTZO-15 is a promising compound for a novel IBD therapeutic drug with ARE activation properties.

  3. New methods to measure and model logistics and goods effects by the use of the CLG-DSS Model

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Jensen, Anders Vestergaard

    2004-01-01

    This paper concerns the assessment and modelling of so-called logistics and goods effects (LG-effects) as part of a wider economic analysis by use of the developed CLG-DSS model. The results presented are based an on-going study, Task 9 about evaluation modelling and decision support systems (DSS...... The aim of this paper is to present these four LG-effects with a special emphasis on a possible way of modelling these and interpreting their importance. The calculations are carried out by using the CLG-DSS model and case studies concerning the fixed links across the Great Belt and Øresund....... It is proposed to model the effects in two ways. First the paper presents a combined method modelling the four effects into one aggregate effect characterized by the goods-related time benefits. Second the paper describes a more refined, disaggregate method approach that, however, at this stage only concerns...

  4. Bacterial β-(1,3)-glucan prevents DSS-induced IBD by restoring the reduced population of regulatory T cells.

    Science.gov (United States)

    Lee, Kwang-Ho; Park, Min; Ji, Kon-Young; Lee, Hwa-Youn; Jang, Ji-Hun; Yoon, Il-Joo; Oh, Seung-Su; Kim, Su-Man; Jeong, Yun-Hwa; Yun, Chul-Ho; Kim, Mi-Kyoung; Lee, In-Young; Choi, Ha-Rim; Ko, Ki-sung; Kang, Hyung-Sik

    2014-10-01

    Bacterial β-(1,3)-glucan has more advantages in terms of cost, yield and efficiency than that derived from mushrooms, plants, yeasts and fungi. We have previously developed a novel and high-yield β-(1,3)-glucan produced by Agrobacterium sp. R259. This study aimed to elucidate the functional mechanism and therapeutic efficacy of bacterial β-(1,3)-glucan in dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).Mice were orally pretreated with bacterial β-(1,3)-glucan at daily doses of 2.5 or 5mg/kg for 2 weeks. After 6 days of DSS treatment, clinical assessment of IBD severity and expression of pro-inflammatory cytokines were evaluated. In vivo cell proliferation was examined by immunohistochemistry using Ki-67 and ER-TR7 antibodies. The frequency of regulatory T cells (Tregs) was analyzed by flow cytometry. Natural killer (NK) activity and IgA level were evaluated using NK cytotoxicity assay and ELISA.The deterioration of body weight gain, colonic architecture, disease score and histological score was recovered in DSS-induced IBD mice when pretreated with bacterial β-(1,3)-glucan. The recruitment of macrophages and the gene expression of proinflammatory cytokines, such as IL-1β, IL-6 and IL-17A/F, were markedly decreased in the colon of β-(1,3)-glucan-pretreated mice. β-(1,3)-Glucan induced the recovery of Tregs in terms of their frequency in DSS-induced IBD mice. Intriguingly, β-(1,3)-glucan reversed the functional defects of NK cells and excessive IgA production in DSS-induced IBD mice.We conclude that bacterial β-(1,3)-glucan prevented the progression of DSS-induced IBD by recovering the reduction of Tregs, functional defect of NK cells and excessive IgA production.

  5. Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.

    Science.gov (United States)

    Zheng, Naiyu; Zeng, Jianing; Ji, Qin C; Angeles, Aida; Aubry, Anne-Francoise; Basdeo, Shenita; Buzescu, Adela; Landry, Ishani Savant; Jariwala, Navin; Turley, Wesley; Burrell, Richard; Arnold, Mark E

    2016-08-31

    Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home. A UHPLC-MS/MS assay was developed using detergent-assisted sample extraction to quantify BMS-927711, a drug candidate in development for the treatment of migraines, in human DSS. By implementing DSS sampling at the patients' home, the bioanalytical sample collection for pharmacokinetic evaluation can be done at the time of the acute migraine attack without the need for clinical visits. DSS samples were prepared by spotting 15 μL of liquid saliva onto regular Whatman FTA™ DMPK-C cards and verified with a UV lamp (at λ 254 nm or 365 nm) during DSS punching. The 4-mm DSS punches in a 96-well plate were sonicated with 200 μL of [(13)C2, D4]-BMS-927711 internal standard (IS) solution in 20/80 MeOH/water for 10 min, followed by sonication with 50 μL of 100 mM NH4OAc with 1.0% Triton-X-100 (as detergent) prior to liquid-liquid extraction with 600 μL EtOAc/Hexane (90:10). UHPLC-MS/MS was performed with an Aquity(®) UPLC BEH C18 Column (2.1 × 50 mm, 1.7 μm) on a Triple Quad™ 5500 mass spectrometer. The assay was linear with a concentration range from 2.00 to 1000 ng mL(-1) for BMS-927711 in human saliva. The intra- and inter-assay precision was within 8.8% CV, and the accuracy was within ±6.7% Dev of the nominal concentration values. This UHPLC-MS/MS assay has been successfully applied to determine the drug's pharmacokinetics within a clinical study. For the first time, we observed BMS-927711 exposure in human DSS, confirming the suitability of this sampling technique for migraine patients to use at home. Detergent-assisted extraction with Triton-X-100 could be very useful in DSS or other dried matrix spot (DMS) assays to overcome low or inconsistent analyte recovery issues.

  6. Present status and development trend of Argos System%Argos系统的发展现状与趋势

    Institute of Scientific and Technical Information of China (English)

    宋飞; 冯旭哲

    2012-01-01

    Argos系统作为具备单星定位能力的卫星通信系统,具有功耗低、体积小、全球覆盖以及数据实时性较好等优点,目前在对自然环境的科学观测中得到了广泛应用.从系统运行的角度,阐述了组成系统的平台部分、空间部分和地面部分;结合第二代和第三代Argos系统,分析了平台终端、空间卫星、地面系统以及主要应用四个方面的发展现状;最后对Argos系统发展趋势进行了探讨和展望.%As a satellite communication system with capability of the single-satellite positioning, Argos system has advantages of low power consumption, small size, global coverage and good real-time ability for data transmission, etc. Due to above merits, Argos system is widely applied in the scientific observation for the marine environment. The platform section, the space segment and the ground segment of which the Argos system consists, are described from the view of system operation. With a comprehensive consideration of the second and the third generation Argos system, the development status of such four aspects as the platform terminal, space satellites, the ground system and the main application field, are analyzed. Finally, an outlook for the development trend of the Argos system is given.

  7. The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function.

    Science.gov (United States)

    Pathania, Amit; Gupta, Arvind Kumar; Dubey, Swati; Gopal, Balasubramanian; Sardesai, Abhijit A

    2016-12-01

    ArgO and LysE are members of the LysE family of exporter proteins and ordinarily mediate the export of l-arginine (Arg) in Escherichia coli and l-lysine (Lys) and Arg in Corynebacterium glutamicum, respectively. Under certain conditions, ArgO also mediates Lys export. To delineate the arrangement of ArgO in the cytoplasmic membrane of E. coli, we have employed a combination of cysteine accessibility in situ, alkaline phosphatase fusion reporters, and protein modeling to arrive at a topological model of ArgO. Our studies indicate that ArgO assumes an Nin-Cout configuration, potentially forming a five-transmembrane helix bundle flanked by a cytoplasmic N-terminal domain (NTD) comprising roughly its first 38 to 43 amino acyl residues and a short periplasmic C-terminal region (CTR). Mutagenesis studies indicate that the CTR, but not the NTD, is dispensable for ArgO function in vivo and that a pair of conserved aspartate residues, located near the opposing edges of the cytoplasmic membrane, may play a pivotal role in facilitating transmembrane Arg flux. Additional studies on amino acid substitutions that impair ArgO function in vivo and their derivatives bearing compensatory amino acid alterations indicate a role for intramolecular interactions in the Arg export mechanism, and some interactions are corroborated by normal-mode analyses. Lastly, our studies suggest that ArgO may exist as a monomer in vivo, thus highlighting the requirement for intramolecular interactions in ArgO, as opposed to interactions across multiple ArgO monomers, in the formation of an Arg-translocating conduit.

  8. CSP Model and Algorithm on Task Allocation for Earth Observation DSS%对地观测DSS任务分配问题的CSP模型与算法

    Institute of Scientific and Technical Information of China (English)

    高黎; 李志猛

    2012-01-01

    任务分配是对地观测分布式卫星系统(Distributed Satellites System,DSS)自主协作运行过程中的一个重要环节.针对任务分配中的约束满足问题(Constraint Satisfaction Problem,CSP),以DSS完成任务总耗能最少为原则,构建了任务分配问题的CSP模型,并引入MAS理论中的合同网协议,给出模型的求解算法,通过仿真算例对模型和算法进行了验证.%With the vigorous development of small satellite technology, there is an increasing desire to use multiple, highly autonomous, earth observation small satellites working together to complete more complicated earth observation missions through autonomous collaboration. Distributed Satel- lites System (DSS) composed by several small satellites is envisioned in the near future because of its capability of higher performance, lower cost, better fault tolerance, reconfigurability and upgrad- ability. Considering the characteristics of autonomous operation cooperatively for DSS in future, the task allocation becomes a very important process in the operation. In the paper, with the principle of lowest general energy-consumption for completing observation task, a model for Constraint Satis- faction Problem (CSP) on task allocation was put forward by analyzing the features of observation task for DSS. Based on it, citing contract net protocol in MAS theory, an algorithm was presented to solve the model and an example of the earth observation satellites was given to validate the model and algorithm at last.

  9. Evaluation of changes in serum chemistry in association with feed withdrawal or high dose oral gavage with Dextran Sodium Sulfate (DSS) induced gut leakage in broiler chickens

    Science.gov (United States)

    Dextran sodium sulfate (DSS) has been shown to be effective at inducing enteric inflammation in broiler chickens, resulting in increased leakage of orally administered fluorescein isothiocyanate dextran to circulation. In a previous study, two doses of DSS (0.45g/dose) administered as oral gavage re...

  10. Augmented activity of the pelvic nerve afferent mediated by TRP channels in dextran sulfate sodium (DSS)-induced colitis of rats.

    Science.gov (United States)

    Makimura, Yukitoshi; Ito, Koichi; Kuwahara, Masayoshi; Tsubone, Hirokazu

    2012-08-01

    Enteritis has been recognized as a major symptom in domestic animals and human patients suffering from feed and food poisonings. The aim of the present study was to clarify the excitatory mechanism of the pelvic nerve afferent which may influence the occurrence of enteritis in response to nociceptive chemical stimuli of the colon in normal and abnormal rats with colitis induced by dextran sulfate sodium (DSS). The pelvic nerve afferent activity was markedly increased by colonic instillation of solution (0.5 ml) of acetic acid (5-25%) and capsaicin (100 μg/ml). The nerve activity was augmented by colonic instillation of capsaicin to a greater extent in rats with DSS-induced colitis than in normal control rats. This augmented activity by capsaicin was more prominent at one day (DSS-1) than at 8 day (DSS-8) after the administration of DSS. The increased nerve activity caused by capsaicin in DSS-1 and DSS-8 was significantly inhibited by pretreatment with ruthenium red, which is a nonselective inhibitor of TRP channels of unmyelinated C-fibers (nociceptors). In conclusion, it was elucidated that the nociceptive function of the pelvic nerve was largely elevated at one day after DSS-induced colitis and such increased function was mostly mediated by TRP channels.

  11. Modelling decision support and uncertainty for large transport infrastructure projects: The CLG-DSS model of the Øresund Fixed Link

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Leleur, Steen; Jensen, Anders Vestergaard

    2007-01-01

    This paper presents a decision support system, named the CLG-DSS model, which makes it possible for decision makers to assess various uncertainties in project appraisal in a systematic and explicit way. This model, a decision support system (DSS) developed within the Danish Centre for Logistics a...

  12. From satellite altimetry to Argo and operational oceanography: three revolutions in oceanography

    Science.gov (United States)

    Le Traon, P. Y.

    2013-10-01

    The launch of the French/US mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large-scale sea level and ocean circulation observations was flying. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. Together with my CLS colleagues, we demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. Near-real-time high-resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 yr. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. Altimetry needs to be complemented with global in situ observations. At the end of the 90s, a major international initiative was launched to develop Argo, the global array of profiling floats. This has been an outstanding success. Argo floats now provide the most important in situ observations to monitor and understand the role of the ocean on the earth climate and for operational oceanography. This is a second revolution in oceanography. The unique capability of satellite altimetry to observe the global ocean in near-real-time at high resolution and the development of Argo were essential for the development of global operational oceanography, the third revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) was instrumental in the development of the required capabilities. This paper provides an historical perspective on the development of these three revolutions in oceanography which are very much interlinked. This is not an exhaustive review and I will mainly focus on the contributions we made together with many colleagues and

  13. From satellite altimetry to Argo and operational oceanography: three revolutions in oceanography

    Directory of Open Access Journals (Sweden)

    P. Y. Le Traon

    2013-10-01

    Full Text Available The launch of the French/US mission Topex/Poseidon (T/P (CNES/NASA in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large-scale sea level and ocean circulation observations was flying. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. Together with my CLS colleagues, we demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. Near-real-time high-resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 yr. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. Altimetry needs to be complemented with global in situ observations. At the end of the 90s, a major international initiative was launched to develop Argo, the global array of profiling floats. This has been an outstanding success. Argo floats now provide the most important in situ observations to monitor and understand the role of the ocean on the earth climate and for operational oceanography. This is a second revolution in oceanography. The unique capability of satellite altimetry to observe the global ocean in near-real-time at high resolution and the development of Argo were essential for the development of global operational oceanography, the third revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE was instrumental in the development of the required capabilities. This paper provides an historical perspective on the development of these three revolutions in oceanography which are very much interlinked. This is not an exhaustive review and I will mainly focus on the contributions we made together with many

  14. CRED SVP Drifting Buoy Argos_ID 30111 Data, French Frigate Shoals in the Northwestern Hawaiian Islands, 200210-200309 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30111 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  15. CRED SVP Drifting Buoy Argos_ID 28078 Data, Stingray Shoals in the Marianas Archipelago, 200308-200412 (NODC Accession 0067473)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 28078 was deployed in the region of Marianas Archipelago to assess ocean currents and sea surface temperature. SVP drifter data files...

  16. CRED SVP Drifting Buoy Argos_ID 29109 Data on the south side of Swains Island, American Samoa , 200402-200606 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29109 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  17. CRED SVP Drifting Buoy Argos_ID 29101 Data, Kure Atoll in the Northwestern Hawaiian Islands, 200308-200509 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29101 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  18. CRED SVP Drifting Buoy Argos_ID 24961 Data, South of Necker, in the Northwestern Hawaiian Islands, 200109-200406 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24961 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  19. CRED SVP Drifting Buoy Argos_ID 24756 Data, 10mn East of Upolu, in the American Samoa, 200307-200310 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24756 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  20. CRED SVP Drifting Buoy Argos_ID 29098 Data, Necker Island in the Northwestern Hawaiian Islands, 200307-200410 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29098 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  1. CRED SVP Drifting Buoy Argos_ID 24946 Data, north of Niihau, in the NW Hawaiian Islands, 200110-200209 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24946 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  2. CRED SVP Drifting Buoy Argos_ID 29102 Data, Lisianski Island in the Northwestern Hawaiian Islands, 200307-200310 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29102 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  3. CRED SVP Drifting Buoy Argos_ID 30288 Data near Necker in the NW Hawaiian Islands, 200209-200404 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30288 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  4. CRED SVP Drifting Buoy Argos_ID 29106 Data, Laysan Island in the Northwestern Hawaiian Islands, 200307-200411 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29106 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  5. CRED SVP Drifting Buoy Argos_ID 24754 Data, between Ofu and Tutuila, in the American Samoa, 200307-200308 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 24754 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  6. CRED SVP Drifting Buoy Argos_ID 44769 Data, Enroute to Manua from Tutuila, in the American Samoa, 200402-200406 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 44769 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  7. CRED SVP Drifting Buoy Argos_ID 30311 Data between Nihoa and Niihau in the NW Hawaiian Islands, 200210-200402 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30311 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  8. CRED SVP Drifting Buoy Argos_ID 29097 Data near Nihoa Island, in the Northwestern Hawaiian Islands, 200307-200412 (NODC Accession 0049436)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 29097 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  9. CRED SVP Drifting Buoy Argos_ID 44770 Data, NW Tutuila in the American Samoa, 200402-200503 (NODC Accession 0067474)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 44770 was deployed in the region of American Samoa to assess ocean currents and sea surface temperature. SVP drifter data files contain...

  10. Impact of Argo Observation on the Regional Ocean Reanalysis of China Coastal Waters and Adjacent Seas: A Twin-Experiment Study

    OpenAIRE

    Caixia Shao; Lili Xuan; Yingzhi Cao; Xiaojian Cui; Siyu Gao

    2015-01-01

    A regional ocean reanalysis system of China coastal waters and adjacent seas, called CORA (China ocean reanalysis), has been recently developed at the National Marine Data and Information Service (NMDIS). In this study, based on CORA, the impact of Argo profiles on the regional reanalysis is evaluated using a twin-experiment approach. It is found that, by assimilating Argo observations, the reanalysis quality is much improved: the root mean square (RMS) error of temperature and salinity can b...

  11. Investigation and rehabilitation to extend service life of DSS-13 antenna concrete foundation

    Science.gov (United States)

    Riewe, A. A., Jr.

    1984-08-01

    An investigation to establish the cause and, devise a repair technique to maintain the serviceability of the DSS-13 26 meter antenna is described. Core samples are obtained from the concrete and various laboratory tests conducted. In-place nondestructive type tests are also performed. The tests established that the concrete is deteriorating because of alkali aggregate reactivity. This is a phenomenon wherein certain siliceous constituents present in some aggregates react with alkalies in the portland cement to produce a silica gel which, in turn, imbibes water, swells, and cracks the concrete. The scheme consists of a supplemental steel frame friction pile anchored grade beam encircling the existing foundation. This system provides adequate bracing against base shear and overturning due to seismic loading. Larger cracks are sealed using a pressure injected two-component epoxy.

  12. Designing a Decision Support System (DSS) for Academic Library Managers Using Preprogrammed Application Software on a Microcomputer.

    Science.gov (United States)

    McDonald, Joseph

    1986-01-01

    Focusing on management decisions in academic libraries, this article compares management information systems (MIS) with decision support systems (DSS) and discusses the decision-making process, information needs of library managers, sources of data, reasons for choosing microcomputer, preprogrammed application software, prototyping a system, and…

  13. Deep structure of crust and the upper mantle of the Mendeleev Rise on the Arktic­-2012 DSS profile

    DEFF Research Database (Denmark)

    Kashubin, Sergey; Petrov, Oleg; Artemieva, Irina;

    2016-01-01

    During high­latitude combined geological and geophysical expedition “Arctic­-2012”, deep seismic sounding (DSS) with ocean bottom seismometers were carried out in the Arctic Ocean along the line 740 km long, crossing the Mendeleev Rise at about 77° N. Crustal and upper mantle Vp­velocity and Vp...

  14. 7 CFR 1955.116 - Requirements for sale of property not meeting decent, safe and sanitary (DSS) standards (housing).

    Science.gov (United States)

    2010-01-01

    ... flooring and floor joists in kitchen and bathroom. —Drill new well to provide for an adequate and potable... agreements. If a housing structure in inventory does not meet DSS standards, Form FmHA or its successor... in the restrictive covenant have been properly completed or the structure(s) razed. A...

  15. Effect of acute and chronic DSS induced colitis on plasma eicosanoid and oxylipin levels in the rat.

    Science.gov (United States)

    Willenberg, Ina; Ostermann, Annika I; Giovannini, Samoa; Kershaw, Olivia; von Keutz, Anne; Steinberg, Pablo; Schebb, Nils Helge

    2015-07-01

    Eicosanoids and oxylipins are potent lipid mediators involved in the regulation of inflammation. In order to evaluate their role and suitability as biomarkers in colitis, we analyzed their systemic levels in the acute and chronic phase of dextran sulfate sodium (DSS) induced colitis. Male Fischer 344 rats were treated in three cycles with 4% DSS in the drinking water (4 days followed by 10 days recovery) and blood was drawn 3 days prior to the first DSS treatment and on days 4, 11, 32 and 39. Histopathological evaluation of the colon tissue after 42 days showed that the animals developed a mild to severe chronic colitis. Consistently, prostaglandin levels were massively (twofold) elevated in the colonic tissue. LC-MS based targeted metabolomics was used to determine plasma oxylipin levels at the different time points. In the acute phase of inflammation directly after DSS treatment, epoxy-fatty acid (FA), dihydroxy-FA and hydroxy-FA plasma concentrations were uniformly elevated. With each treatment cycle the increase in these oxylipin levels was more pronounced. Our data suggest that in the acute phase of colitis release of polyunsaturated FAs from membranes in the inflamed tissue is reflected by a uniform increase of oylipins formed in different branches of the arachidonic acid cascade. However, during the recovery phases the systemic oxylipin pattern is not or only moderately altered and does not allow to evaluate the onset of chronic inflammation in the colon.

  16. Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice : spinal cord c-Fos expression and behavior

    NARCIS (Netherlands)

    Eijkelkamp, Niels; Kavelaars, Annemieke; Elsenbruch, Sigrid; Schedlowski, Manfred; Holtmann, Gerald; Heijnen, Cobi J.

    2007-01-01

    Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior. Am J Physiol Gastrointest Liver Physiol 293: G749-G757, 2007. First published July 26, 2007; doi:10.1152/ajpgi.00114.2007.During acute and chronic inflammation visceral pain perc

  17. Argo floats revealing bimodality of large-scale mid-depth circulation in the North Atlantic

    Institute of Scientific and Technical Information of China (English)

    CHU Peter C; IVANOV Leonid M; MELNICHENKO Oleg V; LI Rongfeng

    2008-01-01

    Analysis of Argo float trajectories at 1000 m and temperature at 950 m in the North Atlantic between November 2003 and January 2005 demonstrates the existence of two different circulation modes with fast transition between them. Each mode has a pair of cy-clonic - anticyclonic gyres. The difference is the location of the cyclonic gyre. The cyclonic gyre stretches from southeast to north-west in the first mode and from the southwest to the northeast in the second mode. The observed modes strongly affect the heat and salt transport in the North Atlantic. In particular, the second mode slows down the westward transport of the warm and saline water from the Mediterranean Sea.

  18. GRBs search results with the ARGO-YBJ experiment operated in Scaler Mode

    CERN Document Server

    Sciascio, G D

    2006-01-01

    The ARGO-YBJ experiment is almost completely installed at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China). The lower energy limit of the detector (E $\\sim$ 1 GeV) is reached with the scaler mode, i.e., recording the single particle rate at fixed time intervals. In this technique, due to its high altitude location and large area ($\\sim$ 6700 m$^2$), this experiment is the most sensitive among all present and past ground-based detectors. In the energy range under investigation, signals due to local (e.g. solar GLEs) and cosmological (e.g. GRBs) phenomena are expected as significant enhancements of the counting rate over the background. Results on the search for GRBs in coincidence with satellite detections are presented.

  19. Measurement of the cosmic rays light component (p+He) primary spectrum with ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Panico, B., E-mail: beatrice.panico@roma2.infn.it [Dipartimento di Fisica, Universita Roma ' Tor Vergata' , Via della Ricerca Scientifica 1, Roma (Italy); INFN, Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy); Di Sciascio, G. [INFN, Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy)

    2012-11-11

    The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, 4300 m a.s.l., 606 g/cm{sup 2}) has an high segmentation that allows the detection of air showers with greater detail and lower energy threshold (a few hundred GeV) compared to other EAS arrays. The spectrum of the primary cosmic ray light (p+He) component in the energy range {approx}10-100TeV is measured selecting quasi-vertical showers ({theta}<15 Degree-Sign ) with the reconstructed core position located in a 40 Multiplication-Sign 40 m{sup 2} fiducial area. The results are compared with other measurements carried out with direct methods.

  20. Deep ocean impact of a Madden-Julian oscillation observed by Argo floats.

    Science.gov (United States)

    Matthews, Adrian J; Singhruck, Patama; Heywood, Karen J

    2007-12-14

    Using the new Argo array of profiling floats that gives unprecedented space-time coverage of the upper 2000 meters of the global ocean, we present definitive evidence of a deep tropical ocean component of the Madden-Julian Oscillation (MJO). The surface wind stress anomalies associated with the MJO force eastward-propagating oceanic equatorial Kelvin waves that extend downward to 1500 meters. The amplitude of the deep ocean anomalies is up to six times the amplitude of the observed annual cycle. This deep ocean sink of energy input from the wind is potentially important for understanding phenomena such as El Niño-Southern Oscillation and for interpreting deep ocean measurements made from ships.

  1. Mangiferin attenuates DSS colitis in mice: Molecular docking and in vivo approach.

    Science.gov (United States)

    Somani, Sahil; Zambad, Shitalkumar; Modi, Ketan

    2016-06-25

    Inflammation, oxidative stress and altered mucosal barrier permeability are potential etiopathological or triggering factors for inflammatory bowel disease (IBD). In this study, the therapeutic potential of Mangiferin was investigated in vivo in mouse model of colitis and also attempts were made to understand mechanistic insights of Mangiferin in IBD. In present study, colitis was induced by administration of 5% DSS for 11 days, followed by 3 days of DSS free period. On day 14, animals were sacrificed and colon tissues were taken for biochemical and histological analysis. Therapeutic treatment with Mangiferin after colitis induction (i.e. day 5) ameliorated symptoms of colitis (presence of blood in stools, body weight loss and diarrhea) as evidenced by reduced DAI score, attenuated the levels of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), myeloperoxidase (MPO). It also decreased the colonic pro-inflammatory mediators tumor necrosis factor (TNF-α), interleukin 1β (IL-1β) levels, matrix metalloproteinase-9 (MMP-9) activity and histopathological score. Molecular docking of Mangiferin against TNF-α and MMP-9 was evaluated using GLIDE software. Mangiferin demonstrated the glide score of -8.04 kcal/mol for TNF-α and -9.97 kcal/mol for MMP-9, which indicated its binding potential with TNF-α and MMP-9. In conclusion, Mangiferin reduces colonic damage in a murine model of colitis, alleviates the oxidative and inflammatory events partly through directly influencing the activity of TNF-α and MMP-9 and therefore might have therapeutic usefulness in the management of inflammatory bowel disease.

  2. Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice.

    Directory of Open Access Journals (Sweden)

    Xiaodi Yang

    Full Text Available BACKGROUND: Many evidences show the inverse correlation between helminth infection and allergic or autoimmune diseases. Identification and characterization of the active helminth-derived products responsible for the beneficial effects on allergic or inflammatory diseases will provide another feasible approach to treat these diseases. METHODS AND FINDINGS: Colitis was induced in C57BL/6 mice by giving 3% DSS orally for 7 days. During this period, the mice were treated daily with the excretory/secretory products from T. spiralis adult worms (AES intraperitoneally. The severity of colitis was monitored by measuring body weight, stool consistency or bleeding, colon length and inflammation. To determine the T. spiralis AES product-induced immunological response, Th1, Th2, Th17 and regulatory cytokine profiles were measured in lymphocytes isolated from colon, mesenteric lymph nodes (MLN, and the spleen of treated mice. The CD4+ CD25+ FOXP3+ regulatory T cells (Tregs were also measured in the spleens and MLN of treated mice. Mice treated with AES significantly ameliorated the severity of the DSS-induced colitis indicated by the reduced disease manifestations, improved macroscopic and microscopic inflammation correlated with the up-regulation of Treg response (increased regulatory cytokines IL-10, TGF-beta and regulatory T cells and down-regulation of pro-inflammatory cytokines (IFN-gamma, IL-6 and IL-17 in the spleens, MLN and colon of treated mice. CONCLUSIONS: Our results provide direct evidences that T. spiralis AES have a therapeutic potential for alleviating inflammatory colitis in mice. This effect is possibly mediated by the immunomodulation of regulatory T cells to produce regulatory and anti-inflammatory cytokines and inhibit pro-inflammatory cytokines.

  3. Impacts of XBT, TAO, Altimetry and ARGO Observations on the Tropical Pacific Ocean Data Assimilation

    Institute of Scientific and Technical Information of China (English)

    YAN Changxiang; ZHU Jiang; ZHOU Guangqing

    2007-01-01

    This study aims at assessing the relative impacts of four major components of the tropical Pacific Ocean observing system on assimilation of temperature and salinity fields. Observations were collected over a period between January 2001 through June 2003 including temperature data from the expendable bathythermographs (XBT), thermistor data from the Tropical Ocean Global Atmosphere Tropical Atmosphere-Ocean (TOGA-TAO) mooring array, sea level anomalies from the Topex/Poseidon and Jason-1 altimetry (T/P-J),and temperature and salinity profiles from the Array for Real-time Geostrophic Oceanography (ARGO) floats.An efficient three-dimensional variational analysis-based method was introduced to assimilate the above data into the tropical-Pacific circulation model. To evaluate the impact of the individual component of the observing system, four observation system experiments were carried out. The experiment that assimilated all four components of the observing system was taken as the reference. The other three experiments were implemented by withholding one of the four components. Results show that the spatial distribution of the data influences its relative contribution. XBT observations produce the most distinguished effects on temperature analyses in the off-equatorial region due to the large amount of measurements and high quality.Similarly, the impact of TAO is dominant in the equatorial region due to the focus of the spatial distribution.The Topex/Poseidon-Jason-1 can be highly complementary where the XBT and TAO observations are sparse.The contribution of XBT or TAO on the assimilated salinity is made by the model dynamics because no salinity observations from them are assimilated. Therefore, T/P-J, as a main source for providing salinity data, has been shown to have greater impacts than either XBT or TAO on the salinity analysis. Although ARGO includes the subsurface observations, the relatively smaller number of observation makes it have the smallest

  4. Estimation of eddy heat transport in the global ocean from Argo data

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhiwei; ZHONG Yisen; TIAN Jiwei; YANG Qingxuan; ZHAO Wei

    2014-01-01

    The Argo data are used to calculate eddy (turbulence) heat transport (EHT) in the global ocean and analyze its horizontal distribution and vertical structure. We calculate the EHT by averaging all the v′, T′ profiles within each 2◦× 2◦ bin. The velocity and temperature anomalies are obtained by removing their clima-tological values from the Argo“instantaneous”values respectively. Through the Student’s t-test and an error evaluation, we obtained a total of 87% Argo bins with significant depth-integrated EHTs (D-EHTs). The results reveal a positive-and-negative alternating D-EHT pattern along the western boundary currents (WBC) and Antarctic Circumpolar Current (ACC). The zonally-integrated D-EHT (ZI-EHT) of the global o-cean reaches 0.12 PW in the northern WBC band and-0.38 PW in the ACC band respectively. The strong ZI-EHT across the ACC in the global ocean is mainly caused by the southern Indian Ocean. The ZI-EHT in the above two bands accounts for a large portion of the total oceanic heat transport, which may play an important role in regulating the climate. The analysis of vertical structures of the EHT along the 35◦N and 45◦S section reveals that the oscillating EHT pattern can reach deep in the northern WBC regions and the Agulhas Return Current (ARC) region. It also shows that the strong EHT could reach 600 m in the WBC re-gions and 1 000 m in the ARC region, with the maximum mainly located between 100 and 400 m depth. The results would provide useful information for improving the parameterization scheme in models.

  5. Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.

    Science.gov (United States)

    Zucker, Stephen D; Vogel, Megan E; Kindel, Tammy L; Smith, Darcey L H; Idelman, Gila; Avissar, Uri; Kakarlapudi, Ganesh; Masnovi, Michelle E

    2015-11-15

    Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS). As VCAM-1 and iNOS are important mediators of tissue injury in the dextran sodium sulfate (DSS) murine model of inflammatory colitis, we examined whether bilirubin prevents colonic injury in DSS-treated mice. Male C57BL/6 mice were administered 2.5% DSS in the drinking water for 7 days, while simultaneously receiving intraperitoneal injections of bilirubin (30 mg/kg) or potassium phosphate vehicle. Disease activity was monitored, peripheral blood counts and serum nitrate levels were determined, and intestinal specimens were analyzed for histological injury, leukocyte infiltration, and iNOS expression. The effect of bilirubin on IL-5 production by HSB-2 cells and on Jurkat cell transendothelial migration also was determined. DSS-treated mice that simultaneously received bilirubin lost less body weight, had lower serum nitrate levels, and exhibited reduced disease severity than vehicle-treated animals. Concordantly, histopathological analyses revealed that bilirubin-treated mice manifested significantly less colonic injury, including reduced infiltration of eosinophils, lymphocytes, and monocytes, and diminished iNOS expression. Bilirubin administration also was associated with decreased eosinophil and monocyte infiltration into the small intestine, with a corresponding increase in peripheral blood eosinophilia. Bilirubin prevented Jurkat migration but did not alter IL-5 production. In conclusion, bilirubin prevents DSS-induced colitis by inhibiting the migration of leukocytes across the vascular endothelium and by suppressing iNOS expression.

  6. Argos Panoptes

    OpenAIRE

    2013-01-01

    Resumen: este texto se desarrolla en un escenario prospectivo de un mundo posible, enmarcado en la era tecno global y situado algunos años en el futuro. La historia está inspirada en los fenómenos y patrones que se han ido desarrollando desde algunos años atrás hasta nuestros días en donde la seguridad y el control ciudadano toman fuerza gracias al auge del sistema global de identificación y la metamorfosis del ciudadano en “sospechoso”. Todos estos fenómenos confluyen en una ciudad en desarr...

  7. 4.5 YEARS OF MULTI-WAVELENGTH OBSERVATIONS OF MRK 421 DURING THE ARGO-YBJ AND FERMI COMMON OPERATION TIME

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S.; Piazzoli, B. D’Ettorre; Girolamo, T. Di [Dipartimento di Fisica dell’Università di Napoli “Federico II,” Complesso Universitario di Monte Sant’Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D’Amone, A.; Mitri, I. De [Dipartimento Matematica e Fisica “Ennio De Giorgi,” Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z.; Feng, Zhaoyang; Gou, Q. B.; Guo, Y. Q. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Cui, S. W. [Hebei Normal University, 050024, Shijiazhuang Hebei (China); Dai, B. Z. [Yunnan University, 2 North Cuihu Road, 650091 Kunming, Yunnan (China); Sciascio, G. Di [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Feng, C. F. [Shandong University, 250100 Jinan, Shandong (China); Feng, Zhenyong, E-mail: chensz@ihep.ac.cn [Southwest Jiaotong University, 610031 Chengdu, Sichuan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2016-01-15

    We report on the extensive multi-wavelength observations of the blazar Markarian 421 (Mrk 421) covering radio to γ-rays, during the 4.5 year period of ARGO-YBJ and Fermi common operation time, from 2008 August to 2013 February. These long-term observations, extending over an energy range of 18 orders of magnitude, provide a unique chance to study the variable emission of Mrk 421. In particular, due to the ARGO-YBJ and Fermi data, the entire energy range from 100 MeV to 10 TeV is covered without any gap. In the observation period, Mrk 421 showed both low- and high-activity states at all wavebands. The correlations among flux variations in different wavebands were analyzed. The X-ray flux is clearly correlated with the TeV γ-ray flux, while the GeV γ-rays only show a partial correlation with the TeV γ-rays. Radio and UV fluxes seem to be weakly or not correlated with the X-ray and γ-ray fluxes. Seven large flares, including five X-ray flares and two GeV γ-ray flares with variable durations (3–58 days), and one X-ray outburst phase were identified and used to investigate the variation of the spectral energy distribution with respect to a relative quiescent phase. During the outburst phase and the seven flaring episodes, the peak energy in X-rays is observed to increase from sub-keV to a few keV. The TeV γ-ray flux increases up to 0.9–7.2 times the flux of the Crab Nebula. The behavior of GeV γ-rays is found to vary depending on the flare, a feature that leads us to classify flares into three groups according to the GeV flux variation. Finally, the one-zone synchrotron self-Compton model was adopted to describe the emission spectra. Two out of three groups can be satisfactorily described using injected electrons with a power-law spectral index around 2.2, as expected from relativistic diffuse shock acceleration, whereas the remaining group requires a harder injected spectrum. The underlying physical mechanisms responsible for different groups may be

  8. LIDERAZGO, LA COMPETENCIA ESENCIAL QUE TRANSFORMÓ UNA EMPRESA COLOMBIANA EN UN GIGANTE INTERNACIONAL: EL CASO DE CEMENTOS ARGOS

    Directory of Open Access Journals (Sweden)

    HÉCTOR OCHOA DÍAZ

    2011-01-01

    Full Text Available Cementos Argos ha sido catalogado como uno de los gigantes de la industria cementera colombiana por su gran capacidad de consolidación en el mercado nacional y sus estrategias de internacionalización poco convencionales. Esta investigación documenta la experiencia internacional de Argos bajo la perspectiva de las teorías de internacionalización de mayor aceptación en laliteratura internacional, haciendo uso del enfoque metodológico de los estudios de caso. Como resultado se encontró que las estrategias de fidelización,aunadas al rediseño organizacional resultado del liderazgo de la alta gerencia, han sido herramientas vitales para asegurar el crecimiento de la compañía en los mercados local y externo.

  9. TeV gamma-ray survey of the northern sky using the ARGO-YBJ experiment

    CERN Document Server

    Cao, Z

    2011-01-01

    The ARGO-YBJ experiment is an extensive air shower array with full coverage RPC detectors located at Yangbajing (4300 m asl, Tibet, China). It is operated with high duty cycle (>86%) and a large field of view ($\\sim$ 2sr). It continuously monitors the entire overhead sky at $\\gamma$-ray energies above 0.1 TeV. In the talk, we will present the result of the northern sky survey (between declinations of -10$^{\\circ}$ and 70$^{\\circ}$) from an analysis of ~4 years of the ARGO-YBJ data (between July 2006 and February 2011). There are four known TeV sources observed with significance greater than 5 S.D.. The significance from Crab Nebula is more than 16 S.D.. 90% confidence level upper limits to the flux from all directions in the sky are also presented, which vary from 0.09 to 0.53 Crab unit for Crab-like point sources.

  10. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data.

    Science.gov (United States)

    Lowther, Andrew D; Lydersen, Christian; Fedak, Mike A; Lovell, Phil; Kovacs, Kit M

    2015-01-01

    Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs) to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE) for each optimal SSM were less than 4.25 km with some producing RMSE of less than 2.50 km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution.

  11. Evaluation of Mid-Depth Currents of NCEP Reanalysis Data in the Tropical Pacific Using ARGO Float Position Information

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The global project of the Array for Real-time Geostrophic Oceanography (ARGO) provides a unique opportunity to observe the absolute velocity in mid-depths of the world oceans. A total of 1597 velocity vectors at 1000 (2000) db in the tropical Pacific derived from the ARGO float position information during the period November 2001 to October 2004 are used to evaluate the intermediate currents of the National Centers for Environmental Prediction reanalysis. To derive reliable velocity information from ARGO float trajectory points, a rigorous quality control scheme is applied, and by virtue of a correction method for reducing the drift error on the surface in obtaining the velocity vectors, their relative errors are less than 25%. Based on the comparisons from the quantitative velocity vectors and from the space-time average currents, some substantial discrepancies are revealed. The first is that the velocities of the reanalysis at mid-depths except near the equator are underestimated relative to the observed velocities by the floats.The average speed difference between NCEP and ARGO values ranges from about -2.3 cms-1 to -1.8cms-1. The second is that the velocity difference between the ocean model and the observations at 2000dB seems smaller than that at 1000 dB. The third is that the zonal flow in the reanalysis is too dominant so that some eddies could not be simulated, such as the cyclonic eddy to the east of 160°E between 20°N and 30°N at 2000 dB. In addition, it is noticeable that many floats parking at 1000 dB cannot acquire credible mid-depth velocities due to the time information of their end of ascent (start of descent) on the surface in the trajectory files. Thus, relying on default times of parking, descent and ascent in the metadata files gravely confines their application to measuring mid-depth currents.

  12. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data.

    Directory of Open Access Journals (Sweden)

    Andrew D Lowther

    Full Text Available Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE for each optimal SSM were less than 4.25 km with some producing RMSE of less than 2.50 km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution.

  13. Observation of the TeV gamma-ray source MGRO J1908+06 with ARGO-YBJ

    CERN Document Server

    ,

    2012-01-01

    The extended gamma ray source MGRO J1908+06, discovered by the Milagro air shower detector in 2007, has been observed for \\sim 4 years by the ARGO-YBJ experiment at TeV energies, with a statistical significance of 6.2 standard deviations. The peak of the signal is found at a position consistent with the pulsar PSR J1907+0602. Parametrizing the source shape with a two-dimensional Gauss function we estimate an extension \\sigma = 0.49 \\pm 0.22 degrees, consistent with a previous measurement by the Cherenkov Array H.E.S.S.. The observed energy spectrum is dN/dE = 6.1 \\pm 1.4 \\times 10^-13 (E/4 TeV)^{-2.54 \\pm 0.36} photons cm^-2 s^-1 TeV^-1, in the energy range \\sim 1-20 TeV. The measured gamma ray flux is consistent with the results of the Milagro detector, but is \\sim 2-3 times larger than the flux previously derived by H.E.S.S. at energies of a few TeV. The continuity of the Milagro and ARGO-YBJ observations and the stable excess rate observed by ARGO-YBJ along 4 years of data taking support the identification...

  14. Decision Support system- DSS- for irrigation management in greenhouses: a case study in Campania Region

    Science.gov (United States)

    Monaco, Eugenia; De Mascellis, Roberto; Riccardi, Maria; Basile, Angelo; D'Urso, Guido; Magliulo, Vincenzo; Tedeschi, Anna

    2016-04-01

    In Mediterranean Countries the proper management of water resources is important for the preservation of actual production systems. The possibility to manage water resources is possible especially in the greenhouses systems. The challenge to manage the soil in greenhouse farm can be a strategy to maintain both current production systems both soil conservation. In Campania region protected crops (greenhouses and tunnels) have a considerable economic importance both for their extension in terms of surface harvested and also for their production in terms of yields. Agricultural production in greenhouse is closely related to the micro-climatic condition but also to the physical and agronomic characteristics of the soil-crop system. The protected crops have an high level of technology compare to the other production systems, but the irrigation management is still carried out according to empirical criteria. The rational management of the production process requires an appropriate control of climatic parameters (temperature, humidity, wind) and agronomical inputs (irrigation, fertilization,). All these factors need to be monitored as well is possible, in order to identify the optimal irrigation schedule. The aim of this work is to implement a Decision Support system -DSS- for irrigation management in greenhouses focused on a smart irrigation control based on observation of the agro-climatic parameters monitored with an advanced wireless sensors network. The study is conducted in a greenhouse farm of 6 ha located in the district of Salerno were seven plots were cropped with rocket. Preliminary a study of soils proprieties was conducted in order to identify spatial variability of the soil in the farm. So undisturbed soil samples were collected to define chemical and physical proprieties; moreover soil hydraulic properties were determined for two soils profiles deemed representation of the farm. Then the wireless sensors, installed at different depth in the soils

  15. Optimal Planning of Sustainable Buildings: Integration of Life Cycle Assessment and Optimization in a Decision Support System (DSS

    Directory of Open Access Journals (Sweden)

    Fabio Magrassi

    2016-06-01

    Full Text Available Energy efficiency measures in buildings can provide for a significant reduction of greenhouse gas (GHG emissions. A sustainable design and planning of technologies for energy production should be based on economic and environmental criteria. Life Cycle Assessment (LCA is used to quantify the environmental impacts over the whole cycle of life of production plants. Optimization models can support decisions that minimize costs and negative impacts. In this work, a multi-objective decision problem is formalized that takes into account LCA calculations and that minimizes costs and GHG emissions for general buildings. A decision support system (DSS is applied to a real case study in the Northern Italy, highlighting the advantage provided by the installation of renewable energy. Moreover, a comparison among different optimal and non optimal solution was carried out to demonstrate the effectiveness of the proposed DSS.

  16. Decision Support System (DSS) for MSMA Integrated Stormwater Management Ecohydrology for Sustainable Green Infrastructure

    Science.gov (United States)

    Sidek, L. M.; Mohiyaden, H. A.; Haris, H.; Basri, H.; Muda, Z. C.; Roseli, Z. A.; Norlida, M. D.

    2016-03-01

    Rapid urbanization has known to have several adverse impacts towards hydrological cycle due to increasing impervious surface and degradation of water quality in stormwater runoff. In the past, urban waterways have been confined to narrow river corridors with the channels canalised and concrete and other synthetic materials forming the bed and banks of the river. Apart from that, stormwater pollutants such as litter, debris and sediments in drainage system are common problems that can lead to flooding and the degradation of water quality. To solve this problem, implementing stormwater Best Management Practices (BMPs) proves very promising due to its near natural characteristics and multiple effects on the drainage of stormwater runoff in urban areas. This judgment of using BMPs depends on not only relevant theoretical considerations, but also a large amount of practical experience and the availability of relevant data, as well. To fulfil this task, the so-called Decision Support System (DSS) in MSMA Design Aid and Database system are able to assist engineers and developers in management and improvement of water quantity and quality entering urban rivers from urban regions. This system is also helpful when an expert level judgment procure some repetitive and large amount of cases, like in the planning of stormwater BMPs systems for an entire city catchment. One of the advantages of an expert system is that it provides automation of expert-level judgement using availability of checking tools system.

  17. SwissDock, a protein-small molecule docking web service based on EADock DSS.

    Science.gov (United States)

    Grosdidier, Aurélien; Zoete, Vincent; Michielin, Olivier

    2011-07-01

    Most life science processes involve, at the atomic scale, recognition between two molecules. The prediction of such interactions at the molecular level, by so-called docking software, is a non-trivial task. Docking programs have a wide range of applications ranging from protein engineering to drug design. This article presents SwissDock, a web server dedicated to the docking of small molecules on target proteins. It is based on the EADock DSS engine, combined with setup scripts for curating common problems and for preparing both the target protein and the ligand input files. An efficient Ajax/HTML interface was designed and implemented so that scientists can easily submit dockings and retrieve the predicted complexes. For automated docking tasks, a programmatic SOAP interface has been set up and template programs can be downloaded in Perl, Python and PHP. The web site also provides an access to a database of manually curated complexes, based on the Ligand Protein Database. A wiki and a forum are available to the community to promote interactions between users. The SwissDock web site is available online at http://www.swissdock.ch. We believe it constitutes a step toward generalizing the use of docking tools beyond the traditional molecular modeling community.

  18. DSS中数据开采技术的研究%Study of Data Mining Technologies in DSS

    Institute of Scientific and Technical Information of China (English)

    周瑛

    2003-01-01

    决策支持系统(DSS)是信息研究的最新发展阶段,已成为计算机应用领域中的重要研究课题.本文详细阐述了DSS中数据开采的三种主要技术,并提出了数据开采的发展方向.

  19. Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines.

    Science.gov (United States)

    Urushima, Hayato; Nishimura, Junichi; Mizushima, Tsunekazu; Hayashi, Noriyuki; Maeda, Kazuhisa; Ito, Toshinori

    2015-01-01

    Anti-inflammatory effects have been reported in Perilla frutescens leaf extract (PE), which is a plant of the genus belonging to the Lamiaceae family. We examined the effect of PE on dextran sulfate sodium (DSS)-induced colitis. Preliminarily, PE was safely administered for 7 wk without any adverse effects. In the preventive protocol, mice were fed 1.5% DSS solution dissolved in distilled water (control group) or 0.54% PE solution (PE group) ad libitum for 7 days. In the therapeutic protocol, distilled water or 0.54% PE solution was given for 10 days just after administration of 1.5% DSS for 5 days. PE intake significantly improved body weight loss. The serum cytokine profile demonstrated that TNF-α, IL-17A, and IL-10 were significantly lower in the PE group than in the control group. In the therapeutic protocol, mice in the PE group showed significantly higher body weight and lower histological colitis scores compared with mice in the control group on day 15. The serum cytokine profile demonstrated that TGF-β was significantly higher in the PE group than in the control group. In distal colon mRNA expression, TNF-α, and IL-17A were significantly downregulated. In vitro analyses of biologically active ingredients, such as luteolin, apigenin, and rosmarinic acid, in PE were performed. Luteolin suppressed production of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-17A. Apigenin also suppressed secretion of IL-17A and increased the anti-inflammatory cytokine IL-10. Rosmarinic acid increased the regulatory T cell population. We conclude that PE might be useful in treatment and prevention of DSS-induced colitis.

  20. Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice.

    Science.gov (United States)

    Zhang, Yinzhong; Brenner, Max; Yang, Weng-Lang; Wang, Ping

    2015-05-01

    Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive system and typically requires lifelong medical care. Recombinant human MFG-E8 (rhMFG-E8) is a 364-amino acid protein, which promotes apoptotic cell clearance and reduces inflammation. This study investigates the therapeutic effect of rhMFG-E8 on two well-established mouse models of IBD. Acute mucosal injury leading to colitis was caused by exposing C57BL/6 mice to 4% dextran sodium sulfate (DSS) in the drinking water over 7 days, and BALB/c mice to a single intrarectal dose of 2.75 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Upon clinical onset of colitis (day 2 in the DSS model and day 1 in the TNBS model), mice were treated with daily subcutaneous injections of rhMFG-E8 (60 or 120 μg/kg/day) or vehicle (saline) for 6 days. Treatment with rhMFG-E8 significantly attenuated colitis in both models in a dose-dependent way. Treatment of DSS-induced colitis with rhMFG-E8 (120 μg/kg/day) decreased weight loss by 59%, the colitis severity score by 71%, and colon shrinkage by 49% when compared with vehicle. Similarly, treatment of TNBS-induced colitis with rhMFG-E8 (120 μg/kg/day) decreased weight loss by 97%, the colitis severity score by 82%, and colon shrinkage by 62% when compared with vehicle. In both models, the colons of animals receiving rhMFG-E8 showed marked reduction in neutrophil infiltration, cytokine and chemokine expression, and apoptotic cell counts. In conclusion, rhMFG-E8 ameliorates DSS- and TNBS-induced colitis, suggesting that it has the potential to become a novel therapeutic agent for IBD.

  1. FLIRE DSS: A web tool for the management of floods and wildfires in urban and periurban areas

    Science.gov (United States)

    Kochilakis, Giorgos; Poursanidis, Dimitris; Chrysoulakis, Nektarios; Varella, Vassiliki; Kotroni, Vassiliki; Eftychidis, Giorgos; Lagouvardos, Kostas; Papathanasiou, Chrysoula; Karavokyros, George; Aivazoglou, Maria; Makropoulos, Christos; Mimikou, Maria

    2016-01-01

    A web-based Decision Support System, named FLIRE DSS, for combined forest fire control and planning as well as flood risk management, has been developed and is presented in this paper. State of the art tools and models have been used in order to enable Civil Protection agencies and local stakeholders to take advantage of the web based DSS without the need of local installation of complex software and their maintenance. Civil protection agencies can predict the behavior of a fire event using real time data and in such a way plan its efficient elimination. Also, during dry periods, agencies can implement "what-if" scenarios for areas that are prone to fire and thus have available plans for forest fire management in case such scenarios occur. Flood services include flood maps and flood-related warnings and become available to relevant authorities for visualization and further analysis on a daily basis. When flood warnings are issued, relevant authorities may proceed to efficient evacuation planning for the areas that are likely to flood and thus save human lives. Real-time weather data from ground stations provide the necessary inputs for the calculation of the fire model in real-time, and a high resolution weather forecast grid supports flood modeling as well as the development of "what-if" scenarios for the fire modeling. All these can be accessed by various computer sources including PC, laptop, Smartphone and tablet either by normal network connection or by using 3G and 4G cellular network. The latter is important for the accessibility of the FLIRE DSS during firefighting or rescue operations during flood events. All these methods and tools provide the end users with the necessary information to design an operational plan for the elimination of the fire events and the efficient management of the flood events in almost real time. Concluding, the FLIRE DSS can be easily transferred to other areas with similar characteristics due to its robust architecture and its

  2. Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB.

    Science.gov (United States)

    Chen, Xi; Liu, Xi-shuang

    2016-03-01

    This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 μmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.

  3. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation.

    Science.gov (United States)

    Liu, Xiaowei; He, Haiyue; Huang, Tingting; Lei, Zhen; Liu, Fuquan; An, Guangyu; Wen, Tao

    2016-01-01

    Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protect against experimental colitis through modulation of neutrophils. We induced colitis in C57BL/6 mice by giving 3% dextran sulfate sodium (DSS) orally, and meanwhile, we treated mice daily with Tanshinone IIA intraperitoneally. The severity of colitis was evaluated by calculating disease activity index (DAI) and histological parameters. Neutrophil infiltration and activation in the colons of mice were measured. Moreover, whether Tanshinone IIA has direct effects on neutrophil migration and activation was determined in vitro. Our data showed that Tanshinone IIA significantly ameliorated the severity of DSS-induced colitis in mice, evidenced by the reduced DAI and improved colonic inflammation. In addition, Tanshinone IIA decreased neutrophil infiltration of intestinal mucosa and activation and reduced colonic inflammatory cytokines in DSS-treated mice. Furthermore, Tanshinone IIA was demonstrated to significantly suppress neutrophil migration and activation. These results provide compelling evidence that Tanshinone IIA has a therapeutic potential for alleviating inflammatory colitis in mice, which is possibly mediated by the immunomodulation of neutrophils.

  4. β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.

    Science.gov (United States)

    Schippers, A; Muschaweck, M; Clahsen, T; Tautorat, S; Grieb, L; Tenbrock, K; Gaßler, N; Wagner, N

    2016-03-01

    Leukocyte recruitment is pivotal for the initiation and perpetuation of inflammatory bowel disease (IBD) and controlled by the specificity and interactions of chemokines and adhesion molecules. Interactions of the adhesion molecules α4β7-integrin and mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) promote the accumulation of pathogenic T-cell populations in the inflamed intestine. We aimed to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of IBD. We demonstrate that β7-integrin deficiency protects recombination-activating gene-2 (RAG-2)-deficient mice from dextran sodium sulfate (DSS)-induced colitis and coincides with decreased numbers of colonic effector monocytes. We also show that β7-integrin is expressed on most CD11b(+)CD64(low)Ly6C(+) bone marrow progenitors and contributes to colonic recruitment of these proinflammatory monocytes. Importantly, adoptive transfer of CD115(+) wild-type (WT) monocytes partially restored the susceptibility of RAG-2/β7-integrin double-deficient mice to DSS-induced colitis, thereby demonstrating the functional importance of β7-integrin-expressing monocytes for the development of DSS colitis. We also reveal that genetic ablation of MAdCAM-1 ameliorates experimental colitis in RAG-2-deficient mice as well. In summary, we demonstrate a previously unknown role of α4β7-integrin-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  5. Computer Based ex-ante Evaluation of the Planned Railway Line between Copenhagen and Ringsted by use of a Decision Support System named COSIMA-DSS

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Landex, Alex

    2006-01-01

    This paper presents an appraisal study concerning the extension of the main railway line between Copenhagen and Ringsted by use of a software system named COSIMA-DSS. The modelling system is based upon a multi-methodological approach combining a cost-benefit analysis together with a multi......, results from the calculations using COSIMA-DSS are presented and discussed on the basis of a newly developed Danish manual on transport appraisal....

  6. ARGOS III: Stellar Populations in the Galactic Bulge of the Milky Way

    CERN Document Server

    Ness, M; Athanassoula, E; de Boer, E Wylie; Hawthorn, J Bland; Asplund, M; Lewis, G F; Yong, D; Lane, R R; Kiss, L L

    2012-01-01

    We present the metallicity results from the ARGOS spectroscopic survey of the Galactic bulge. Our aim is to understand the formation of the Galactic bulge: did it form via mergers, as expected from Lambda CDM theory, or from disk instabilities, as suggested by its boxy/peanut shape, or both? We have obtained spectra for 28,000 stars at a spectral resolution of R = 11,000. From these spectra, we have determined stellar parameters and distances to an accuracy of -0.5 are part of the boxy/peanut bar/bulge. We associate the lower metallicity stars ([Fe/H] -0.5, we find two discrete populations; (i) stars with [Fe/H] ~ -0.25 which provide a roughly constant fraction of the stars in the latitude interval b = -5 deg to -10 deg, and (ii) a kinematically colder, more metal-rich population with mean [Fe/H] ~ +0.15 which is more prominent closer to the plane. The changing ratio of these components with latitude appears as a vertical abundance gradient of the bulge. We attribute both of these bulge components to instab...

  7. Observation of the Cosmic Ray Moon shadowing effect with the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, G

    2011-01-01

    Cosmic rays are hampered by the Moon and a deficit in its direction is expected (the so-called \\emph{Moon shadow}). The Moon shadow is an important tool to determine the performance of an air shower array. In fact, the displacement of the shadow center, due to the bending effect of the Geomagnetic field on the propagation of cosmic rays, allows to set the energy scale of the primary particles inducing the showers observed by the detector. The shape of the shadow permits to determine the detector point spread function. The position of the deficit at high energy allows evaluating its pointing accuracy. Here we present the observation of the cosmic ray Moon shadowing effect carried out by the ARGO-YBJ experiment (Yangbajing Cosmic Ray Laboratory, Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$) in the multi-TeV energy region with high statistical significance (70 standard deviations). By means of an accurate Monte Carlo simulation of the cosmic rays propagation in the Earth-Moon system we have studied the role of...

  8. Gamma ray flares from Mrk421 in 2008 observed with the ARGO-YBJ detector

    CERN Document Server

    al., G Aielli et

    2010-01-01

    In 2008 the blazar Markarian 421 entered a very active phase and was one of the brightest sources in the sky at TeV energies, showing frequent flaring episodes. Using the data of ARGO-YBJ, a full coverage air shower detector located at Yangbajing (4300 m a.s.l., Tibet, China), we monitored the source at gamma ray energies E > 0.3 TeV during the whole year. The observed flux was variable, with the strongest flares in March and June, in correlation with X-ray enhanced activity. While during specific episodes the TeV flux could be several times larger than the Crab Nebula one, the average emission from day 41 to 180 was almost twice the Crab level, with an integral flux of (3.6 +-0.6) 10^-11 photons cm^-2 s^-1 for energies E > 1 TeV, and decreased afterwards. This paper concentrates on the flares occurred in the first half of June. This period has been deeply studied from optical to 100 MeV gamma rays, and partially up to TeV energies, since the moonlight hampered the Cherenkov telescope observations during the ...

  9. Gamma-Ray Flares from Mrk421 in 2008 observed with the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, G

    2009-01-01

    In 2008, the blazar Mrk421 entered in a very active phase and was one of the brightest sources in the sky at TeV energies, showing strong and frequent flaring. We searched for gamma-ray emission at energies E > 0.8 TeV during the whole 2008 with the ARGO-YBJ experiment, a full coverage air shower detector located at Yangbajing (4300 m a.s.l., Tibet, P.R. China). The observed signal is not constant and in correlation with X-ray measurements. The average emission, during the active period of the source, was about twice the Crab Nebula level, with an integral flux of (4.9$\\pm 2.0$)x 10$^{-11}$ photons cm$^{-2}$ s$^{-1}$ for E$_{\\gamma}$ >1 TeV. This paper concentrates on 2008 June when the Mrk421 flaring activity has been studied from optical to 100 MeV gamma rays, and only partially up to TeV energies, since the moonlight hampered the Cherenkov telescope observations after 8 June. Our data complete these observations, with the detection of a second flare of intensity of about 7 Crab units on June 11-13, with a ...

  10. Latest results on cosmic ray physics from the ARGO-YBJ experiment

    Energy Technology Data Exchange (ETDEWEB)

    De Mitri, Ivan [Dipartimento di Matematica e Fisica “E. De Giorgi”, Università del Salento, Lecce (Italy); Istituto Nazionale di Fisica Nucleare (INFN) - Sezione di Lecce, Lecce (Italy)

    2014-04-01

    Cosmic ray physics in the 10{sup 12}–10{sup 15} eV primary energy range is among the main scientific goals of the ARGO-YBJ experiment. The detector, located in the Cosmic Ray Observatory of Yangbajing (Tibet, China) at 4300 m a.s.l., is a full coverage extensive air shower array consisting of a carpet of Resistive Plate Chambers (RPCs) distributed over an area of more than 10 000 m{sup 2}. The apparatus layout, performance and location offer a unique opportunity for a detailed study of several characteristics of the hadronic component of the cosmic ray flux in an energy window marked by the transition from direct to indirect measurements. Moreover, the analog readout of the RPC signals indeed provides a powerful tool to study, with unprecedented resolution and without saturation, the extensive air shower space–time structure down to few meters from its axis. Latest results concerning the study of cosmic ray energy spectrum, mass composition and arrival directions will be given together with the search for an antiproton signal, the proton–air cross-section measurement, the study of the interplanetary magnetic field, and the effects of the geomagnetic field on secondary particles. Furthermore, particle distributions close to the shower axis are being extensively studied, also giving new inputs, in the very forward region, to the hadronic interaction models currently used for understanding particle physics and cosmic rays up to the highest energies.

  11. Measurement of the Cosmic Ray Energy Spectrum with ARGO-YBJ

    CERN Document Server

    ,

    2014-01-01

    The ARGO-YBJ detector, located at high altitude in the Cosmic Ray Observatory of Yangbajing in Tibet (4300 m asl, about 600 g/cm2 of atmospheric depth) provides the opportunity to study, with unprecedented resolution, the cosmic ray physics in the primary energy region between 10^{12} and 10^{16} eV. The preliminary results of the measurement of all-particle and light-component (i.e. protons and helium) energy spectra between approximately 5 TeV and 5 PeV are reported and discussed. The study of such energy region is particularly interesting because not only it allows a better understanding of the so called 'knee' of the energy spectrum and of its origin, but also provides a powerful cross-check among very different experimental techniques. The comparison between direct measurements by balloons/satellites and the results by surface detectors, implying the knowledge of shower development in the atmosphere, also allows to test the hadronic interaction models currently used for understanding particle and cosmic ...

  12. Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.

    Science.gov (United States)

    Velasquez, Clara Vasquez; Roman, Arthur Dessi; Lan, Nguyen Thi Phuong; Huy, Nguyen Tien; Mercado, Edelwisa Segubre; Espino, Fe Esperanza; Perez, Ma Lucila M; Huong, Vu Thi Que; Thuy, Tran Thi; Tham, Vo Dinh; Nga, Cao Thi Phi; Ha, Tran Thi Ngoc; Bilar, Josie M; Bajaro, Jemimah Dawn P; Baello, Benilda Q; Kikuchi, Mihoko; Yasunami, Michio; Morita, Kouichi; Watanabe, Naohiro; Karbwang, Juntra; Hirayama, Kenji

    2015-05-01

    We previously reported, significantly higher levels of Chymase and Tryptase in early stage plasma of DSS patients prior to the occurrence of shock suggesting a possible role of mast cells in dengue pathogenesis. To further investigate, we analyzed CMA1 promoter SNP (rs1800875) and TPSAB1 gene alleles, which encode the Human Chymase and α- and β- tryptase 1 enzymes respectively, for susceptibility to Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in patients from hospitals in Vietnam (Ho Chi Minh City and Vinh Long) and the Philippines. While the CMA1 promoter SNP (rs1800875) was not associated with DHF/DSS, the homozygous form of α-tryptase allele was associated with DSS patients in Vinh Long and the Philippines (OR=3.52, pDSS were combined in Vinh Long (OR=1.5, p=0.034) and the Philippines (OR=2.36, p=0.0004); in Ho Chi Minh City when DHF and DSS were combine an association was observed, but it was not statistically significant (OR=1.5, p=0.0505). Therefore, the α-tryptase might have a possible effect on the susceptibility to severe form of Dengue infection.

  13. Investigation of wind erosion process for estimation, prevention, and control of DSS in Yazd-Ardakan plain.

    Science.gov (United States)

    Ekhtesasi, M R; Sepehr, A

    2009-12-01

    Wind erosion is a phenomenon that is reasonably common in regions where dry winds blow. For the most part, these regions correspond to the dry lands; areas where the soil, generally, is dry and shifting and lacks vegetation for most of the year. The winds are sufficiently strong to lift and move sands and soil particles. The repeated removal of superficial layers by the action of winds can modify the texture of the topsoil, by removing the fine particles and leaving the larger particles. Dust and sandstorm (DSS) is the generic term for a serious environmental phenomenon that involves strong winds that blow a large quantity of dust and fine sand particles away from the ground and carry them over a long distance with significant environmental impacts along the way. In the realm of DSS in Iran country, the people who live in Yazd and Sistan-Baluchestan provinces form a single ecological community due to their geographic proximity and climatic contiguity. The major sources of DSS in the region are believed to be the desert and semidesert areas of the Yazd-Ardakan plain in Yazd province. Both Sistan and Baluchestan are the recipients of this dust. To address the long-range transboundary environmental problem of DSS, a regional cooperation mechanism must be established among the provinces in the region. Yazd-Ardakan plain, with area of about 650,000 ha, is located in the center of Iran, between Yazd and Ardakan cities. The mean annual rainfall is less than 65 mm. Rainfall distribution is a simple modal and more than 70% of it occurs in winter. Plant density varies from 0% to 25%, and Artemisia sieberi is the dominant plant species. The major part of Yazd-Ardakan plain is bare land. According to the recent investigation, more than 20,000-m(3) dust with less than 100-microm diameter falls down annually on Yazd city with an area of 7,000 ha. Horizontal visibility is reduced to less than 6 m in stormy days in some parts of Yazd-Ardakan plain. This phenomenon causes car

  14. OBSERVATION OF THE TeV GAMMA-RAY SOURCE MGRO J1908+06 WITH ARGO-YBJ

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S. [Dipartimento di Fisica dell' Universita di Napoli ' Federico II' , Complesso Universitario di Monte Sant' Angelo, via Cinthia, 80126 Napoli (Italy); Bernardini, P.; Bleve, C. [Dipartimento di Matematica e Fisica ' Ennio De Giorgi' , Universita del Salento, via per Arnesano, 73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Bolognino, I. [Dipartimento di Fisica Nucleare e Teorica dell' Universita di Pavia, via Bassi 6, 27100 Pavia (Italy); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, 00146 Roma (Italy); Melcarne, A. K. Calabrese [Istituto Nazionale di Fisica Nucleare-CNAF, Viale Berti-Pichat 6/2, 40127 Bologna (Italy); Camarri, P. [Dipartimento di Fisica dell' Universita di Roma ' Tor Vergata' , via della Ricerca Scientifica 1, 00133 Roma (Italy); Cardarelli, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, 00133 Roma (Italy); Cattaneo, C. [Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, via Bassi 6, 27100 Pavia (Italy); Chen, T. L. [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, 73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z. [Yunnan University, 2 North Cuihu Rd., 650091 Kunming, Yunnan (China); Staiti, G. D' Ali [Dipartimento di Fisica, Universita degli Studi di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Collaboration: Argo-YBJ Collaboration; and others

    2012-12-01

    The extended gamma-ray source MGRO J1908+06, discovered by the Milagro air shower detector in 2007, has been observed for {approx}4 years by the ARGO-YBJ experiment at TeV energies, with a statistical significance of 6.2 standard deviations. The peak of the signal is found at a position consistent with the pulsar PSR J1907+0602. Parameterizing the source shape with a two-dimensional Gauss function, we estimate an extension of {sigma}{sub ext} = 0.{sup 0}49 {+-} 0.{sup 0}22, which is consistent with a previous measurement by the Cherenkov Array H.E.S.S. The observed energy spectrum is dN/dE = 6.1 {+-} 1.4 Multiplication-Sign 10{sup -13} (E/4 TeV){sup -2.54{+-}0.36} photons cm{sup -2} s{sup -1} TeV{sup -1}, in the energy range of {approx}1-20 TeV. The measured gamma-ray flux is consistent with the results of the Milagro detector, but is {approx}2-3 times larger than the flux previously derived by H.E.S.S. at energies of a few TeV. The continuity of the Milagro and ARGO-YBJ observations and the stable excess rate observed by ARGO-YBJ and recorded in four years of data support the identification of MGRO J1908+06 as the steady powerful TeV pulsar wind nebula of PSR J1907+0602, with an integrated luminosity over 1 TeV {approx} 1.8 times the luminosity of the Crab Nebula.

  15. Estimation of the proton energy spectrum in knee region by analog read-out of ARGO-YBJ experiment

    Institute of Scientific and Technical Information of China (English)

    QU Xiao-Bo; CHEN Song-Zhan; ZHA Min; ZHANG Xue-Yao; FENG Cun-Feng

    2008-01-01

    Based on the six months data set of ARGO-YBJ experiment with analog read-out and its Monte Carlo simulation,we study the difference between different primaries induced showers by using the space-time information of the charged particles in Extensive Air Showers.With five parameters which can efficiently pick out primary proton induced showers as inputs of an artificial neural network,the proton spectrum from 100 TeV to 10 PeV can be obtained.

  16. Experimental Research on Atmospheric Electric Field and Extensive Air Shower Particle Increasing During Thunderstorms with ARGO-YBJ

    Institute of Scientific and Technical Information of China (English)

    XU Bin; ZHANG Ying; JIA Huan-Yu

    2008-01-01

    From April lst to August 14th, 2006, thunderstorms had been recorded at Yangbajing Cosmic Ray Observatory by ARGO-YBJ experiment. This paper analyzed the correlation between atmospheric electric field (AEF) and "scaler mode" counting rate during thunderstorm. Counting rates of multiplicities n = 1,2 were found to have a large increase ( from 1.02% to 9.03% ), while there was few or no changes in those of multiplicities n =3 and n≥4 during the thunderstorms. The counts of different multiplicities had different feedbacks on the violent change of AEF, which showed that their energy and most components were distinguishing.

  17. Measurement of the cosmic ray all-particle and light-component energy spectra with the ARGO-YBJ experiment

    Directory of Open Access Journals (Sweden)

    De Mitri I.

    2015-01-01

    Full Text Available The ARGO-YBJ detector, located at high altitude in the Cosmic Ray Observatory of YangBaJing in Tibet (4300 m asl, about 600 g/cm2 of atmospheric depth provides the opportunity for the study, with unprecedented resolution, of cosmic ray physics in the primary energy region between 1012 and 1016 eV. Preliminary results of the measurements of the all-particle and light-component (i.e. protons and helium energy spectra between approximately 5 TeV and 5 PeV are reported and discussed.

  18. Revision of deposition and weathering parameters for the ingestion dose module (ECOSYS) of the ARGOS and RODOS decision support systems

    DEFF Research Database (Denmark)

    Andersson, Kasper Grann; Nielsen, Sven Poul; Thørring, Håvard;

    2011-01-01

    The ECOSYS model is the ingestion dose model integrated in the ARGOS and RODOS decision support systems for nuclear emergency management. The parameters used in this model have however not been updated in recent years, where the level of knowledge on various environmental processes has increased...... considerably. A Nordic work group has carried out a series of evaluations of the general validity of current ECOSYS default parameters. This paper specifically discusses the parameter revisions required with respect to the modelling of deposition and natural weathering of contaminants on agricultural crops...

  19. Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17.

    Science.gov (United States)

    Sun, Yan; Lin, Lian-Jie; Lin, Yan; Sang, Li-Xuan; Jiang, Min; Zheng, Chang-Qing

    2015-01-01

    This study explored the underlying mechanism of Gingko biloba extract (Ginaton) on dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. 40 male C57BL/6 mice were randomly divided into four groups: normal control group, Ginaton group, Ginaton treatment group, and DSS group. After 7 days administration, mice were sacrificed and colons were collected for H-E staining, immunohistochemistry, real-time PCR and Western blot. By observing clinical disease activity and histological damage, we assessed the effect of Ginaton on DSS-induced acute experimental colitis in mice and observed the effect of Ginaton on normal mice. We also explored the specific mechanism of Ginaton on DSS-induced acute experimental colitis in mice through examining the expression of inflammatory related mediators (gp130, STAT3, p-STAT3, ROR-γt) and cytokines (IL-6, IL-17, IL-23). Ginaton-treated DSS mice showed significant improvement over untreated DSS mice. Specifically, Ginaton improved clinical disease activity (DAI score, weight closs, colon shortening, and bloody stool) and histological damage, and reduced the expression of inflammatory-related mediators (p-STAT3, gp130, ROR-γt) and cytokines (IL-6, IL-17, IL-23). In addition, clinical disease activity, histological damage, the expression of inflammatory related mediators (STAT3, p-STAT3, gp130, ROR-t) and cytokines (IL-6, IL-17, IL-23) in mice of Ginaton group were similar to normal control group. In conclusion, Ginaton ameliorates DSS-induced acute experimental colitis in mice by reducing IL-17 production, which is at least partly involved in inhibiting IL-6/STAT3 signaling pathway and IL-23/IL-17 axis. Moreover, Ginaton itself does not cause inflammatory change in normal mice. These results support that Ginaton can be as a potential clinical treatment for ulcerative colitis (UC).

  20. Mesoscale variability of water masses in the Arabian Sea as revealed by ARGO floats

    Directory of Open Access Journals (Sweden)

    X. Carton

    2011-06-01

    Full Text Available By analysing ARGO float data over the last four years, some aspects of the mesoscale variability of water masses in the Arabian Sea are described.

    The Red Sea Water outflow is strong in the Southwestern Gulf of Aden, in particular when a cyclonic gyre predominates in this region. Salinities of 36.5 and temperatures of 16 °C are found there between 600 and 1000 m depths. The Red Sea Water is more dilute in the eastern part of the Gulf, and fragments of this water mass can be advected offshore across the gulf or towards its northern coast by the regional gyres. The Red Sea Water outflow is also detected along the northeastern coast of Socotra, and fragments of RSW are found between one and three degrees of latitude north of this island. In the whole Gulf of Aden, the correlation between the deep motions of the floats and the SSH measured by altimetry is strong, at regional scale. The finer scale details of the float trajectories are more often related to the anomalous water masses that they encounter.

    The Persian Gulf Water (PGW is found in the float profiles near Ras ash Sharbatat (near 57° E, 18° N, again with 36.5 in salinity and about 18–19 °C in temperature. These observations were achieved in winter when the southwestward monsoon currents can advect PGW along the South Arabian coast. Fragments of PGW are found in the Arabian Sea between 18 and 20° N and 63 and 65° E, showing that this water mass can escape the Gulf of Oman southeastward, in particular during summer.

  1. Interaction between Meso-scale Eddies and Sub-polar Front in the East (Japan) Sea based on ARGO, AVHRR, and Numerical Model

    Science.gov (United States)

    Ro, Y.; Kim, E.

    2008-12-01

    The East (Japan) Sea is drawing keen international attentions from broad spectrum of groups such as scientists, diplomats, and defense officers for its geopolitical situation, peculiar scientific assets recognized as miniature ocean. From physical oceanographic aspect, it is very rich with many features such as basin-wide circulation pattern, boundary currents, sub-polar front, meso-scale eddy activities and deep water formation. The circulation pattern in the East (Japan) Sea has been of major interests for its peculiar gyre, a western boundary current and its separation that resembles the currents such as Kuroshio and Gulf Stream. In relation to the gyre system in the East Sea, the formation of the East Korea Warm Current (EKWC) has brought up with many numerical experiments. Numerical experiments suggested a new idea to explain the formation of the EKWC in that the potential energy supply into the Ulleung Basin (UB) from the meso-scale eddy is a key process. This is closely linked with the baroclinic instability and the meandering of offshore component of Tsushima Warm Current. The UB has drawn attentions for its role of the formation of two major boundary currents, EKWC, North Korea Warm Current (NKCC), their interaction with the mesoscale UWE, watermass exchange between the Northern Japan Basin and UB. Numerical experiments along with hydrographic and other satellite datasets such as AVHRR, altimeter and ARGO profiles have been analyzed to understand the formation of the UWE. We found that the influence of the bottom topography and frictional forcing against lateral boundary are all closely associated with the sub-polar front. Meandering of the axis of the sub-polar front is closely linked with the separation point of the EKWC, Ulleung Warm Eddy, and other small and meso-scale eddies on the sub-polar front. These will be demonstrated with results of the numerical modeling experiments and animation movie will be presented.

  2. Decommissioning process of the experimental nuclear reactor ARGOS, sited at the Technical School of Industrial Engineering in Barcelona; Proceso de desmantelamiento del reactor nuclear experimental Argos de la Universidad Politecnica de Catalunya

    Energy Technology Data Exchange (ETDEWEB)

    Ortega Aramburu, X.; Duch Guillen, M. A.

    2005-07-01

    The experimental nuclear reactor ARGOS, sited at the Technical School of Industrial Engineering in Barcelona, was an experimental reactor used for training purposes, from 1963 to 1977. Due to economic and administrative circumstances this facility was closed down at the end of this period and the fuel remained the fuel inside the reactor core. In 1994 the fuel was removed. The administrative licence was finally agreed with the authorities in 1998 after a long delay. The decommissioning operations began in 2001. The University dismantled, temporarily stored, checked and classified about 1200 components with a total weight of 154.4 t. The material which was declassified from the radiation protection point of view was approximately 99.9% of all the material. After presenting the final documents to the appropriate authorities the formal closing declaration was agreed in December 2003. After this date the site could be used for any purpose and it was the first case of the decommissioning of a nuclear reactor in Spain. Recently the ARGOS building have been finally demolished. (Author)

  3. The electrical conductivities of the DSS-13 beam-waveguide antenna shroud material and other antenna reflector surface materials

    Science.gov (United States)

    Otoshi, T. Y.; Franco, M. M.; Reilly, H. F., Jr.

    1992-01-01

    A significant amount of noise temperature can potentially be generated by currently unknown dissipative losses in the beam waveguide (BWG) shroud. The amount of noise temperature contribution from this source is currently being studied. In conjunction with this study, electrical conductivity measurements were made on samples of the DSS-13 BWG shroud material at 8.420 GHz. The effective conductivities of unpainted and painted samples of the BWG shroud were measured to be 0.01 x 10(exp 7) and 0.0036 x 10(exp 7) mhos/m, respectively. This value may be compared with 5.66 x 10(exp 7) mhos/m for high conductivity copper.

  4. FLIRE DSS: A web tool for the management of floods and wildfires in urban and periurban areas

    Directory of Open Access Journals (Sweden)

    Kochilakis Giorgos

    2016-01-01

    Full Text Available A web-based Decision Support System, named FLIRE DSS, for combined forest fire control and planning as well as flood risk management, has been developed and is presented in this paper. State of the art tools and models have been used in order to enable Civil Protection agencies and local stakeholders to take advantage of the web based DSS without the need of local installation of complex software and their maintenance. Civil protection agencies can predict the behavior of a fire event using real time data and in such a way plan its efficient elimination. Also, during dry periods, agencies can implement “what-if” scenarios for areas that are prone to fire and thus have available plans for forest fire management in case such scenarios occur. Flood services include flood maps and flood-related warnings and become available to relevant authorities for visualization and further analysis on a daily basis. When flood warnings are issued, relevant authorities may proceed to efficient evacuation planning for the areas that are likely to flood and thus save human lives. Real-time weather data from ground stations provide the necessary inputs for the calculation of the fire model in real-time, and a high resolution weather forecast grid supports flood modeling as well as the development of “what-if” scenarios for the fire modeling. All these can be accessed by various computer sources including PC, laptop, Smartphone and tablet either by normal network connection or by using 3G and 4G cellular network. The latter is important for the accessibility of the FLIRE DSS during firefighting or rescue operations during flood events. All these methods and tools provide the end users with the necessary information to design an operational plan for the elimination of the fire events and the efficient management of the flood events in almost real time. Concluding, the FLIRE DSS can be easily transferred to other areas with similar characteristics due to its

  5. COSIMA-DSS Evaluation System: A new Decision Support System for Large-Scale Transport Infrastructure Projects

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Jensen, Anders Vestergaard; Leleur, Steen

    2005-01-01

    This paper presents a new decision support model COSIMA-DSS that examines socio-economic feasibility risks involved in the implementation of transport infrastructure projects. The model makes use of conventionally cost-benefit analysis embedded within a wider multi-criteria analysis. The basic...... approach set out in the paper looks upon the mix between so-called “hard” and “soft” evaluation criteria. Finally, a Monte-Carlo simulation is used to take account of the varying information relating to the different criteria....

  6. LandCaRe DSS--an interactive decision support system for climate change impact assessment and the analysis of potential agricultural land use adaptation strategies.

    Science.gov (United States)

    Wenkel, Karl-Otto; Berg, Michael; Mirschel, Wilfried; Wieland, Ralf; Nendel, Claas; Köstner, Barbara

    2013-09-01

    Decision support to develop viable climate change adaptation strategies for agriculture and regional land use management encompasses a wide range of options and issues. Up to now, only a few suitable tools and methods have existed for farmers and regional stakeholders that support the process of decision-making in this field. The interactive model-based spatial information and decision support system LandCaRe DSS attempts to close the existing methodical gap. This system supports interactive spatial scenario simulations, multi-ensemble and multi-model simulations at the regional scale, as well as the complex impact assessment of potential land use adaptation strategies at the local scale. The system is connected to a local geo-database and via the internet to a climate data server. LandCaRe DSS uses a multitude of scale-specific ecological impact models, which are linked in various ways. At the local scale (farm scale), biophysical models are directly coupled with a farm economy calculator. New or alternative simulation models can easily be added, thanks to the innovative architecture and design of the DSS. Scenario simulations can be conducted with a reasonable amount of effort. The interactive LandCaRe DSS prototype also offers a variety of data analysis and visualisation tools, a help system for users and a farmer information system for climate adaptation in agriculture. This paper presents the theoretical background, the conceptual framework, and the structure and methodology behind LandCaRe DSS. Scenario studies at the regional and local scale for the two Eastern German regions of Uckermark (dry lowlands, 2600 km(2)) and Weißeritz (humid mountain area, 400 km(2)) were conducted in close cooperation with stakeholders to test the functionality of the DSS prototype. The system is gradually being transformed into a web version (http://www.landcare-dss.de) to ensure the broadest possible distribution of LandCaRe DSS to the public. The system will be continuously

  7. Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity.

    Science.gov (United States)

    Zhang, H L; Zheng, Y J; Pan, Y D; Xie, C; Sun, H; Zhang, Y H; Yuan, M Y; Song, B L; Chen, J F

    2016-03-01

    Integrin α4β7 controls lymphocyte trafficking into the gut and has essential roles in inflammatory bowel disease (IBD). The α4β7-blocking antibody vedolizumab is approved for IBD treatment; however, high dose of vedolizumab aggravates colitis in a small percentage of patients. Herein, we show that integrin β7 deficiency results in colonic regulatory T (Treg) cell depletion and exacerbates dextran sulfate sodium (DSS) colitis by evoking aberrant innate immunity. In DSS-treated β7-deficient mice, the loss of colonic Treg cells induces excessive macrophage infiltration in the colon via upregulation of colonic epithelial intercellular adhesion molecule 1 and increases proinflammatory cytokine expression, thereby exacerbating DSS-induced colitis. Moreover, reconstitution of the colonic Treg cell population in β7-deficient mice suppresses aberrant innate immune response in the colon and attenuates DSS colitis. Thus, integrin α4β7 is essential for suppression of DSS colitis as it regulates the colonic Treg cell population and innate immunity.

  8. An Ensemble Recentering Kalman Filter with an Application to Argo Temperature Data Assimilation into the NASA GEOS-5 Coupled Model

    Science.gov (United States)

    Keppenne, Christian L.

    2013-01-01

    A two-step ensemble recentering Kalman filter (ERKF) analysis scheme is introduced. The algorithm consists of a recentering step followed by an ensemble Kalman filter (EnKF) analysis step. The recentering step is formulated such as to adjust the prior distribution of an ensemble of model states so that the deviations of individual samples from the sample mean are unchanged but the original sample mean is shifted to the prior position of the most likely particle, where the likelihood of each particle is measured in terms of closeness to a chosen subset of the observations. The computational cost of the ERKF is essentially the same as that of a same size EnKF. The ERKF is applied to the assimilation of Argo temperature profiles into the OGCM component of an ensemble of NASA GEOS-5 coupled models. Unassimilated Argo salt data are used for validation. A surprisingly small number (16) of model trajectories is sufficient to significantly improve model estimates of salinity over estimates from an ensemble run without assimilation. The two-step algorithm also performs better than the EnKF although its performance is degraded in poorly observed regions.

  9. Implementation of position assimilation for ARGO floats in a realistic Mediterranean Sea OPA model and twin experiment testing

    Directory of Open Access Journals (Sweden)

    V. Taillandier

    2006-05-01

    Full Text Available In this paper, a Lagrangian assimilation method is presented and implemented in a realistic OPA OGCM with the goal of providing an assessment of the assimilation of realistic Argo float position data. We focus on an application in the Mediterranean Sea, where in the framework of the MFSTEP project an array of Argo floats have been deployed with parking depth at 350 m and sampling interval of 5 days. In order to quantitatively test the method, the ''twin experiment'' approach is followed and synthetic trajectories are considered. The method is first tested using ''perfect'' data, i.e. without shear drift errors and with relatively high coverage. Results show that the assimilation is effective, correcting the velocity field at the parking depth, as well as the velocity profiles and the geostrophically adjusted mass field. We then consider the impact of realistic datasets, which are spatially sparse and characterized by shear drift errors. Such data provide a limited global correction of the model state, but they efficiently act on the location, intensity and shape of the described mesoscale structures of the intermediate circulation.

  10. OBSERVATION OF TeV GAMMA RAYS FROM THE CYGNUS REGION WITH THE ARGO-YBJ EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S. [Dipartimento di Fisica dell' Universita di Napoli ' Federico II' , Complesso Universitario di Monte Sant' Angelo, via Cinthia, 80126 Napoli (Italy); Bernardini, P.; Bleve, C. [Dipartimento di Fisica dell' Universita del Salento, via per Arnesano, 73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Bolognino, I. [Dipartimento di Fisica Nucleare e Teorica dell' Universita di Pavia, via Bassi 6, 27100 Pavia (Italy); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, 00146 Roma (Italy); Calabrese Melcarne, A. K. [Istituto Nazionale di Fisica Nucleare-CNAF, Viale Berti-Pichat 6/2, 40127 Bologna (Italy); Camarri, P. [Dipartimento di Fisica dell' Universita di Roma ' Tor Vergata' , via della Ricerca Scientifica 1, 00133 Roma (Italy); Cardarelli, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, 00133 Roma (Italy); Cattaneo, C. [Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, via Bassi 6, 27100 Pavia (Italy); Chen, T. L. [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, 73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z. [Yunnan University, 2 North Cuihu Road, 650091 Kunming, Yunnan (China); D' Ali Staiti, G., E-mail: chensz@ihep.ac.cn [Dipartimento di Fisica e Tecnologie Relative, Universita degli Studi di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Collaboration: ARGO-YBJ Collaboration; and others

    2012-02-15

    We report the observation of TeV {gamma}-rays from the Cygnus region using the ARGO-YBJ data collected from 2007 November to 2011 August. Several TeV sources are located in this region including the two bright extended MGRO J2019+37 and MGRO J2031+41. According to the Milagro data set, at 20 TeV MGRO J2019+37 is the most significant source apart from the Crab Nebula. No signal from MGRO J2019+37 is detected by the ARGO-YBJ experiment, and the derived flux upper limits at the 90% confidence level for all the events above 600 GeV with medium energy of 3 TeV are lower than the Milagro flux, implying that the source might be variable and hard to be identified as a pulsar wind nebula. The only statistically significant (6.4 standard deviations) {gamma}-ray signal is found from MGRO J2031+41, with a flux consistent with the measurement by Milagro.

  11. Observation of TeV gamma rays from the Cygnus region with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bleve, C; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Cattaneo, C; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2012-01-01

    We report the observation of TeV gamma-rays from the Cygnus region using the ARGO-YBJ data collected from 2007 November to 2011 August. Several TeV sources are located in this region including the two bright extended MGRO J2019+37 and MGRO J2031+41. According to the Milagro data set, at 20 TeV MGRO J2019+37 is the most significant source apart from the Crab Nebula. No signal from MGRO J2019+37 is detected by the ARGO-YBJ experiment, and the derived flux upper limits at 90% confidence level for all the events above 600 GeV with medium energy of 3 TeV are lower than the Milagro flux, implying that the source might be variable and hard to be identified as a pulsar wind nebula. The only statistically significant (6.4 standard deviations) gamma-ray signal is found from MGRO J2031+41, with a flux consistent with the measurement by Milagro.

  12. Long-term monitoring of the TeV emission from Mrk 421 with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bleve, C; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cappa, A; Cardarelli, R; Catalanotti, S; Cattaneo, C; Celio, P; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G D'Alí; Danzengluobu,; Dattoli, M; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Galeotti, P; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Qu, X B; Rossi, E; Ruggieri, F; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Stanescu, C; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yan, Y X; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2011-01-01

    ARGO-YBJ is an air shower detector array with a fully covered layer of resistive plate chambers. It is operated with a high duty cycle and a large field of view. It continuously monitors the northern sky at energies above 0.3 TeV. In this paper, we report a long-term monitoring of Mrk 421 over the period from 2007 November to 2010 February. This source was observed by the satellite-borne experiments Rossi X-ray Timing Explorer and Swift in the X-ray band. Mrk 421 was especially active in the first half of 2008. Many flares are observed in both X-ray and gamma-ray bands simultaneously. The gamma-ray flux observed by ARGO-YBJ has a clear correlation with the X-ray flux. No lag between the X-ray and gamma-ray photons longer than 1 day is found. The evolution of the spectral energy distribution is investigated by measuring spectral indices at four different flux levels. Hardening of the spectra is observed in both X-ray and gamma-ray bands. The gamma-ray flux increases quadratically with the simultaneously measur...

  13. Measurement of Cosmic Ray antiproton/proton flux ratio at TeV energies with ARGO-YBJ

    CERN Document Server

    Di Sciascio, G

    2011-01-01

    Cosmic ray antiprotons provide an important probe for the study of cosmic-ray propagation in the interstellar space and to investigate the existence of Galactic dark matter. The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$), is the only experiment exploiting the full coverage approach at very high altitude presently at work. The ARGO-YBJ experiment is particularly effective in measuring the cosmic ray antimatter content via the observation of the cosmic rays Moon shadowing effect. Based on all the data recorded during the period from July 2006 through November 2009 and a full Monte Carlo simulation, we searched for the existence of the shadow produced by antiprotons at the few-TeV energy region. No evidence of the existence of antiprotons was found in this energy region. Upper limits to the antip/p flux ratio are set to 5 % at a median energy of 2 TeV and 6 % at 5 TeV with a confidence level of 90 %. In the few-TeV energy range this resul...

  14. A needlet-based approach to the shower-mode data analysis in the ARGO-YBJ experiment

    Energy Technology Data Exchange (ETDEWEB)

    Iuppa, R., E-mail: roberto.iuppa@roma2.infn.it [Department of Physics, University of Tor Vergata (Italy); INFN, Sezione di Roma Tor Vergata (Italy); Di Sciascio, G. [INFN, Sezione di Roma Tor Vergata (Italy); Hansen, F.K. [Institute of Theoretical Astrophysics, University of Oslo (Norway); Marinucci, D. [Department of Mathematics, University of Tor Vergata (Italy); Santonico, R. [Department of Physics, University of Tor Vergata (Italy); INFN, Sezione di Roma Tor Vergata (Italy)

    2012-11-11

    The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, 4300 m a.s.l., 606 g/cm{sup 2}), is an EAS-array exploiting the full coverage approach at high altitude. The large field of view (2 sr) and the low energy threshold (few hundreds of GeV) result in a trigger rate of {approx}3.5kHz and {approx}10{sup 11}EAS collected per year. Such a data set contains signals laying on different angular scales: point-like and extended gamma-ray sources, as well as large and intermediate scale cosmic-ray anisotropies. The separation of all these contributions is crucial, mostly when they overlap with each other. Needlets are a new form of spherical wavelets that have recently drawn a lot of attention in the cosmological literature, especially in connection with the analysis of CMB data. Needlets enjoy a number of important statistical and numerical properties which suggest that they can be very effective in handling cosmic-ray and gamma-ray data analysis. An unprecedented application to astroparticle physics is shown here. In particular, we focus on their use for background estimation, which is expected to be optimal or nearly-optimal in a well-defined mathematical sense, and for point-source detection. This technique is applied here to the ARGO-YBJ data set, stressing its advantages with respect to standard methods.

  15. Interpretation of Postmodern Feminism in Argo%《逃离德黑兰》的后现代女性主义解读

    Institute of Scientific and Technical Information of China (English)

    张乔源

    2015-01-01

    作为一部惊心动魄、扣人心弦的政治大片,《逃离德黑兰》充斥着浓烈的美国式个人英雄主义和爱国主义。然而爱国主义主旋律的背后却也隐藏着不可磨灭的男权印记。基于后现代女性主义,从男性话语霸权、两性二元对立思维模式以及女性内部的异化和压迫等三个方面着手,分析《逃离德黑兰》中的男权色彩。%As one of the most impressive political films, Argo is filled with American individual heroism and patriotism.However, be-hind the cover of patriotism, Argo reflects the patriarchal society and male chauvinism.Based on Postmodern Feminism, this paper at-tempts to analyze Argo from the perspective of the discourse hegemony of male, gender dichotomy as well as the internal alienation and oppression of female, so as to reflect the patriarchy in Argo.

  16. The use of AQUATOOL DSS applied to the System of Environmental-Economic Accounting for Water (SEEAW)

    Science.gov (United States)

    Pedro-Monzonís, María; Jiménez-Fernández, Pedro; Solera, Abel; Jiménez-Gavilán, Pablo

    2016-02-01

    Currently, water accounts are one of the next steps to be implemented in European River Basin Management Plans. Building water accounts is a complex task, mainly due to the lack of common European definitions and procedures. For their development, when data is not systematically measured, simulation models and estimations are necessary. The main idea of this paper is to present a new approach which enables the combined use of hydrological models and water resources models developed with AQUATOOL Decision Support System (DSS) to fill in the physical water supply and use tables and the asset accounts presented in the System of Economic and Environmental Accounts for Water (SEEAW). The case study is the Vélez River Basin, located in the southern part of the Iberian Peninsula in Spain. In addition to obtaining the physical water supply and use tables and the asset accounts in this river basin, we present here the indicators as a result thereof. These indicators cover many critical aspects of water management, showing a general description of the river basin and allowing decision-makers to characterise the pressures on water resources. As a general conclusion, the union of AQUATOOL DSS and SEEAW will provide more complete information to decision-makers and it enables to introduce these methodological decisions in order to guarantee consistency and comparability of the results between different river basins.

  17. Faecalibacterium prausnitzii Strain HTF-F and Its Extracellular Polymeric Matrix Attenuate Clinical Parameters in DSS-Induced Colitis.

    Directory of Open Access Journals (Sweden)

    Oriana Rossi

    Full Text Available A decrease in the abundance and biodiversity of intestinal bacteria within the Firmicutes phylum has been associated with inflammatory bowel disease (IBD. In particular, the anti-inflammatory bacterium Faecalibacterium prausnitzii, member of the Firmicutes phylum and one of the most abundant species in healthy human colon, is underrepresented in the microbiota of IBD patients. The aim of this study was to investigate the immunomodulatory properties of F. prausnitzii strain A2-165, the biofilm forming strain HTF-F and the extracellular polymeric matrix (EPM isolated from strain HTF-F. For this purpose, the immunomodulatory properties of the F. prausnitzii strains and the EPM were studied in vitro using human monocyte-derived dendritic cells. Then, the capacity of the F. prausnitzii strains and the EPM of HTF-F to suppress inflammation was assessed in vivo in the mouse dextran sodium sulphate (DSS colitis model. The F. prausnitzii strains and the EPM had anti-inflammatory effects on the clinical parameters measured in the DSS model but with different efficacy. The immunomodulatory effects of the EPM were mediated through the TLR2-dependent modulation of IL-12 and IL-10 cytokine production in antigen presenting cells, suggesting that it contributes to the anti-inflammatory potency of F. prausnitzii HTF-F. The results show that F. prausnitzii HTF-F and its EPM may have a therapeutic use in IBD.

  18. DSS中的数据库管理子系统分析与应用%Analysis and Application of the Database Management Subsystem in DSS

    Institute of Scientific and Technical Information of China (English)

    邹修明; 张岳新

    2001-01-01

    This paper makes a comparison between Decision Support System (DSS) and Management Information System (MIS) on data management. It introduces some of current methods for data management, focussing on an analysis on the composition and architecture of database management subsystem in DSS. Besides, it illustrates , with an example, key problems that should be taken into account during building a data management subsystem in DSS.%文章比较了 DSS与MIS在数据管理上的差异,列出了DSS中常用的几种数据管理方法,重点分析了DSS数据库管理子系统的组成和结构,并结合开发实例,说明了建立DSS数据库管理子系统时应考虑的主要问题。

  19. An upper ocean response to Typhoon Bolaven analyzed with Argo profiling floats

    Institute of Scientific and Technical Information of China (English)

    LIU Zenghong; XU Jianping; SUN Chaohui; WU Xiaofen

    2014-01-01

    In situ observations from Argo profiling floats combined with satellite retrieved SST and rain rate are used to investigate an upper ocean response to Typhoon Bolaven from 20 through 29 August 2012. After the passage of Typhoon Bolaven, the deepening of mixed layer depth (MLD), and the cooling of mixed layer temperature (MLT) were observed. The changes in mixed layer salinity (MLS) showed an equivalent number of increasing and decreasing because the typhoon-induced salinity changes in the mixed layer were influenced by precipi-tation, evaporation, turbulent mixing and upwelling of thermocline water. The deepening of the MLD and the cooling of the MLT indicated a significant rightward bias, whereas the MLS was freshened to the left side of the typhoon track and increased on the other side. Intensive temperature and salinity profiles observed by Iridium floats make it possible to view response processes in the upper ocean after the passage of a typhoon. The cooling in the near-surface and the warming in the subsurface were observed by two Iridium floats located to the left side of the cyclonic track during the development stage of the storm, beyond the radius of maxi-mum winds relative to the typhoon center. Water salinity increases at the base of the mixed layer and the top of the thermocline were the most obvious change observed by those two floats. On the right side of the track and near the typhoon center when the typhoon was intensified, the significant cooling from sea surface to a depth of 200×104 Pa, with the exception of the water at the top of the thermocline, was observed by the other Iridium float. Owing to the enhanced upwelling near the typhoon center, the water salinity in the near-surface increased noticeably. The heat pumping from the mixed layer into the thermocline induced by downwelling and the upwelling induced by the positive wind stress curl are the main causes for the different temperature and salinity variations on the different sides of the

  20. Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon.

    Science.gov (United States)

    Chen, Menglu; Gao, Lei; Chen, Pan; Feng, Dandan; Jiang, Yalin; Chang, Yongchao; Jin, Jianjun; Chu, Fong-Fong; Gao, Qiang

    2016-01-01

    Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims. To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-induced colitis. Materials and Methods. C57BL/6J (B6) mice were treated with either low-dose (1.0 mg/kg) or high-dose (2.0 mg/kg) 5-HT by enema, low-dose (1.0%) or high-dose (2.5%) DSS, or combined low-dose (1.0%) DSS and (1.0 mg/kg) 5-HT. Mouse colitis was analyzed. MMPs and tissue inhibitors of MMPs (TIMPs) mRNA were measured by real-time quantitative RT-PCR in mouse colon and in human Caco-2 cells and neutrophils. MMP-3 and MMP-9 protein levels were quantified from immunohistochemistry (IHC) images of mouse colons. Results. 5-HT exacerbated DSS-induced colitis, low-dose 5-HT induces both MMP-3 and MMP-9, and high-dose 5-HT only increased MMP-3 mRNA expression in mouse colon. Mouse colon MMP-3 and MMP-9 protein levels were also elevated by 5-HT treatment. The MMP-2, TIMP-1, and TIMP-2 mRNA levels were increased in the inflamed colon. 5-HT induced MMP-3 and MMP-9 mRNA expression in Caco-2 and human neutrophils, respectively, in vitro. Conclusion. 5-HT induced MMP-3 and MMP-9 expression in mouse colon; these elevated MMPs may contribute to DSS-induced colitis.

  1. Surface motility in Pseudomonas sp DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum

    DEFF Research Database (Denmark)

    Andersen, Jens Bo; Koch, Birgit; Nielsen, T.H.;

    2003-01-01

    Pseudomonas sp. DSS73 was isolated from the rhizoplane of sugar beet seedlings. This strain exhibits antagonism towards the root-pathogenic microfungi Pythium ultimum and Rhizoctonia solani. Production of the cyclic lipopeptide amphisin in combination with expression of flagella enables the growing...... bacterial culture to move readily over the surface of laboratory media. Amphisin is a new member of a group of dual-functioning compounds such as tensin, viscosin and viscosinamid that display both biosurfactant and antifungal properties. The ability of DSS73 to efficiently contain root...

  2. Temperature and salinity profiles from CTD casts from the ARGOS and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 November 1989 to 30 November 1989 (NODC Accession 8900297)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the ARGOS and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  3. Temperature profiles from XBT casts from the AMERICAN ARGO as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1980-05-02 to 1980-06-02 (NODC Accession 8000380)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the AMERICAN ARGO from 02 May 1980 to 02 June 1980. Data were collected by Moore-McCormack Lines Inc. as part...

  4. Effects of interannual salinity variability on the dynamic height in the western equatorial Pacific as diagnosed by Argo

    Institute of Scientific and Technical Information of China (English)

    ZHENG Fei; WANG Hui; WAN Liying

    2015-01-01

    In this paper, interannual variations of the ocean dynamic height over the tropical Pacific are diagnosed using three-dimensional temperature and salinity fields from Argo profiles, with a focus on the effects of interannually varying salinity on the El Ni(n)o-Southern Oscillation (ENSO) evolutions. The diagnostic analyses clearly demonstrate a significant and large role that the salinity field plays in modulating the sea surface dynamic height (SSDH) in the western tropical Pacific. In particular, the contribution of the interannually varying salinity to the interannual variations in SSDH approximately equals to that of the interannually varying temperature. Over the western equatorial Pacific, the salinity variability was responsible for a 30% to 40% reduction in SSDH anomaly in opposition to the thermal build up in SSDH anomaly, providing an important contribution to modulating the seasonal-to-interannual evolution of the tropical Pacific Ocean and affecting the developing of ENSO events.

  5. Selection of Surviving Primary Protons at 4300 m a.s.l. with the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, G

    2007-01-01

    The primary proton spectrum up to 100 TeV has been investigated by balloon- and satellite-borne instruments. Above this energy range only ground-based air shower arrays can measure the cosmic ray spectrum with a technique moderately sensitive to nuclear composition. An array which exploits the full coverage approach at very high altitude can achieve an energy threshold well below the TeV region, thus allowing, in principle, the inter-calibration of the measured proton content in the primary cosmic ray flux with the existing direct measurements from balloons/satellites. The capability of the ARGO-YBJ experiment, located at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China), in selecting the surviving primary cosmic ray protons is discussed. A procedure looking for quasi-unaccompanied events with a very steep lateral distribution is also presented.

  6. Variability of surface velocity in the Kuroshio Current and adjacent waters derived from Argos drifter buoys and satellite altimeter data

    Institute of Scientific and Technical Information of China (English)

    MA Chao; WU Dexing; LIN Xiaopei

    2009-01-01

    By combining Argos drifter buoys and TOPEX/POSEIDON altimeter data, the time series of sea-surface velocity fields in the Kuroshio Current (KC) and adjacent regions are established. And the variability of the KC from the Luzon Strait to the Tokara Strait is studied based on the velocity fields. The results show that the dominant variability period varies in different segments of the KC" The primary period near the Luzon Strait and to the east of Taiwan Island is the intra-seasonal time scale; the KC on the continental shelf of the ECS is the steadiest segment without obvious periodicity, while the Tokara Strait shows the period of seasonal variability. The diverse periods are caused by the Rossby waves propagating from the interior ocean, with adjustments in topography of island chain and local wind stress.

  7. Assimilation of simulated satellite altimetric data and ARGO temperature data into a double-gyre NEMO ocean model

    Science.gov (United States)

    Yan, Yajing; Barth, Alexander; Laenen, François; Beckers, Jean-Marie

    2013-04-01

    In recent years, data assimilation, adressing the problem of producing useful analyses and forecasts given imperfect dynamical models and observations, has shown increasing interest in the atmosphere and ocean science community. The efficiency of data assimilation in improving the model prediction has been proven by numerous work. However, it is still a challenge to design operational data assimilation schemes which can be operated with realistic ocean models, with reasonable quality and at acceptable cost. In this work, several experiments, assimilating the simulated altimetry and temperature observations into a double-gyre NEMO ocean model, are performed with objective to investigate the impact of different assimilation setups, including changing the observation distribution, the ensemble size and the localisation scale, on the quality of the analysis. The double-gyre NEMO ocean model corresponds to an idealized configuration of the NEMO model: a square and 5000-meter deep flat bottom ocean at mid latitudes (the so called square-box or SQB configuration). The main physical parameters governing the dominant characteristics of the flow are the initial stratification, the wind stress, the bottom friction and the lateral mixing parameterization. The domain extends from 24N to 44N, over 30° in longitude (60W - 30W) with 11 vertical levels between 152 m and 4613 m in depth. The minimum horizontal resolution of the model is 1/4°. The observations are generated from the model simulations (the truth) by adding spatially uncorrelated gaussian noise with given standard deviation. Two types of observation are considered : sea surface height (SSH) and temperature. The observation grid of the SSH is simulated from the ENVISAT and Jason-1 satellite tracks, and that of the temperature is generated in order to mimic the ARGO float profile. The observation localisation is performed in order to avoid spurious correlation at large distance. For this, the observations are weighted

  8. Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.

    Science.gov (United States)

    Yin, Jie; Wu, Miaomiao; Duan, Jielin; Liu, Gang; Cui, Zhijie; Zheng, Jie; Chen, Shuai; Ren, Wenkai; Deng, Jinping; Tan, Xiangwen; Al-Dhabi, Naif Abdullah; Duraipandiyan, Veeramuthu; Liao, Peng; Li, Tiejun; Yulong, Yin

    2015-12-01

    Inflammatory bowel disease (IBD) correlates with oxidative stress, inflammation, and alteration in several signal pathways, including nuclear transcription factor-kappaB (NF-κB). Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB, has been widely demonstrated to exhibit an antioxidant and anti-inflammatory function. This study aimed to test the hypothesis that NF-κB inhibitor PDTC confers a beneficial role in a colitis model induced by dextran sodium sulfate (DSS) in mouse. The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppressed the expression of antioxidant enzymes and tight junctions, and activated NF-κB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathways. PDTC significantly upregulated (P < 0.05) Gpx1, Gpx4, occludin, and ZO-1 expressions in the DSS-induced colitis model. Meanwhile, PDTC reversed (P < 0.05) the activation of NF-κB signal pathway caused by DSS treatment. In conclusion, PDTC could serve as an adjuvant therapy for the patient with IBD.

  9. Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.

    Science.gov (United States)

    Dranse, Helen J; Rourke, Jillian L; Stadnyk, Andrew W; Sinal, Christopher J

    2015-08-01

    Inflammatory bowel disease (IBD) is a family of disorders including ulcerative colitis and Crohn's disease that are characterized by chronic and relapsing intestinal inflammation. Increased production of proinflammatory mediators, possibly combined with low expression of anti-inflammatory mediators, is thought to promote the development and progression of IBD. In the current study, we demonstrate that expression, secretion, and processing of chemerin, a potent chemoattractant for cells expressing chemokine-like receptor 1 (CMKLR1), increased in the cecum and colon along a gradient positively associated with the severity of inflammation in dextran sodium sulfate (DSS)-induced colitis. We also show that levels of circulating bioactive chemerin increased following DSS treatment. At both 6-8 and 14-16 weeks of age, CMKLR1 knockout mice developed signs of clinical illness more slowly than wild type and had changes in circulating cytokine levels, increased spleen weight, and increased local chemerin secretion following DSS treatment. However, knockout mice ultimately developed similar levels of clinical illness and local inflammation as wild type. Finally, contrary to previous reports, intraperitoneal injection of bioactive chemerin had no effect on the severity of DSS-induced colitis. This suggests that local chemerin levels have a greater impact than circulating levels in the pathogenesis of colitis. Considered altogether, bioactive chemerin represents a novel biomarker for IBD severity, although strategies to modulate endogenous chemerin signaling other than chronic CMKLR1 loss are necessary in order to exploit chemerin as a therapeutic target for the treatment of IBD.

  10. Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.

    Science.gov (United States)

    Ledesma-Soto, Yadira; Callejas, Blanca E; Terrazas, César A; Reyes, Jose L; Espinoza-Jiménez, Arlett; González, Marisol I; León-Cabrera, Sonia; Morales, Rosario; Olguín, Jonadab E; Saavedra, Rafael; Oghumu, Steve; Satoskar, Abhay R; Terrazas, Luis I

    2015-01-01

    Chronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB/c and C57BL/6 mice. Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice. Taenia infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced. RT-PCR assays from colon showed that T. crassiceps-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice. The percentages of T regulatory cells were not increased. The adoptive transfer of alternatively activated macrophages (AAMФs) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation. Administration of indomethacin abrogated the anticolitic effect of Taenia. Thus, T. crassiceps infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAMФs and prostaglandins.

  11. Suppression of MAPK and NF-κ B pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease.

    Science.gov (United States)

    Liu, Weidong; Liu, Yang; Wang, Zhi; Yu, Ting; Lu, Qin; Chen, Hong

    2015-09-01

    Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignan isolated from the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill, possesses various biological activities, such as hepatic protection, anti-tumor, anti-inflammatory and anti-cardiovascular properties. However, the effect of Sch B on inflammatory bowel disease (IBD) is not yet known. The aim of this study was to investigate whether Sch B has protective effect against dextran sulfate sodium (DSS)-induced colitis in a mouse model. The acute mouse model of IBD was induced by drinking 2.5% DSS water for 5 days. Sch B was administered orally in doses of 10, 40, and 100 mg/kg respectively. It significantly reduced concentration of TNF-α, IL-1β, INF-γ and IL-6 in colon tissue as well as the mRNA expression levels. In addition, we demonstrated that Sch B blocked the phosphorylation of IκBα, nuclear factor-κB (NF-κB) p65, p38 mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase, and extracellular signal regulated kinase in DSS-induced acute colitis. In conclusion, these results indicated that Sch B could exert beneficial effects on experimental IBD induced by DSS and may represent a novel treatment strategy for IBD.

  12. Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons.

    Science.gov (United States)

    Lv, Qi; Qiao, Si-miao; Xia, Ying; Shi, Can; Xia, Yu-feng; Chou, Gui-xin; Wang, Zheng-tao; Dai, Yue; Wei, Zhi-feng

    2015-12-01

    Norisoboldine (NOR), the main active constituent of Radix Linderae, was previously demonstrated to ameliorate collagen-induced arthritis in rats through regulating the imbalance of T cells in intestines, which implied its therapeutic potential in inflammatory bowel disease. Here, we investigated the effect of NOR on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice. Results showed that NOR (20, 40mg/kg) markedly reduced the symptoms of colitis, the levels of IL-1β and TNF-α, and the activation of ERK, p38 MAPK and NF-κB-p65. NOR only slightly decreased the levels of IFN-γ and IL-17A in mouse colons, but it dramatically increased the level of IL-10 at both protein and mRNA grades. Consistently, NOR increased the number of CD4(+)CD25(+)Foxp3(+) Treg cells more obviously than it decreased that of CD4(+)IL-17(+) Th17 cells in mesenteric lymph nodes (MLNs) and colonic lamina proprias (LPs) of colitis mice, and promoted the expression of Foxp3 mRNA in colon tissues. It could facilitate the in vitro differentiation of Treg cells from naive T cells and promote the phosphorylations of Smad2/3 in colon tissues of colitis mice. On the other hand, NOR did not affect the expressions of homing receptors CCR9 and α4β7 in SPs, and homing ligands CCL25 and Madcam-1 in MLNs and colonic LPs, suggesting that the increase of Treg cells in colons by NOR was not due to gut homing. In conclusion, NOR can ameliorate DSS-induced UC in mice, and the mechanisms involve reduction of pro-inflammatory cytokines and selective induction of Treg cells in colons.

  13. Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.

    Science.gov (United States)

    Deng, Que; Chen, Hongyu; Liu, Yanjun; Xiao, Fengjun; Guo, Liang; Liu, Dan; Cheng, Xiang; Zhao, Min; Wang, Xiaomeng; Xie, Shuai; Qi, Siyong; Yin, Zhaoyang; Gao, Jiangping; Chen, Xintian; Wang, Jiangong; Guo, Ning; Ma, Yuanfang; Shi, Ming

    2016-10-01

    Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition. Psychological stress has been postulated to affect the clinical symptoms and recurrence of IBD. The exact molecular mechanisms are not fully understood. In the present study, we demonstrate that psychological stress promotes neutrophil infiltration into colon tissues in dextran sulfate sodium (DSS)-induced colitis model. The psychological stress resulted in abnormal expression of the proinflammatory cytokines (IL-1β, IL-6, IL-17A, and IL-22) and neutrophil chemokines (CXCL1 and CXCL2) and overactivation of the STAT3 inflammatory signaling pathway. Under chronic unpredictable stress, the adrenergic nervous system was markedly activated, as the expression of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, in bone marrow and colonic epithelium was enhanced, especially in the myenteric ganglia. The β-AR agonist isoproterenol mimicked the effects of psychological stress on neutrophilia, neutrophil infiltration, and colonic damage in DSS-induced colitis. The β1-AR/β2-AR inhibitor propranolol reduced the numbers of the neutrophils in the circulation, suppressed neutrophil infiltration into colonic tissues, and attenuated the colonic tissue damage promoted by chronic stress. Propranolol also abolished stress-induced upregulation of proinflammatory cytokines and neutrophil chemokines. Our data reveal a close linkage between the β1-AR/β2-AR activation and neutrophil trafficking and also suggest the critical roles of adrenergic nervous system in exacerbation of inflammation and damage of colonic tissues in experimental colitis. The current study provides a new insight into the mechanisms underlying the association of psychological stress with excessive inflammatory response and pathophysiological consequences in IBD. The findings also suggest a potential application of neuroprotective agents to prevent relapsing immune activation in the treatment of IBD.

  14. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.

    Science.gov (United States)

    El-Salhy, Magdy; Umezawa, Kazuo

    2016-03-01

    The aim of this study was to determine the effects of two anti-inflammatory agents on the abnormalities in colonic endocrine cells in dextran sodium sulfate (DSS)-induced colitis. Colitis was induced in male Wistar rats (n=45) using DSS; a further 15 rats without colitis were included in a healthy control group. The animals with DSS-induced colitis were randomly divided into 3 treatment groups as follows: i) DSS group, rats were treated with 0.5 ml of 0.5% carboxymethyl cellulose (CMC); ii) DSS‑G group, rats were treated with 3-[(dodecylthiocarbonyl)‑methyl]‑glutarimide (DTCM‑G), a novel activator protein 1 (AP-1) inhibitor, 20 mg/kg in CMC; and iii) DSS‑Q group, rats were treated with dehydroxymethylepoxyquinomicin, a nuclear factor κB (NF-κB) inhibitor, 15 mg/kg in CMC. The treatments were administered intraperitoneally, twice daily for 5 days, after which the animals were sacrificed and tissue samples from the colon were immunostained for chromogranin A (CgA), serotonin, peptide YY (PYY), enteroglucagon, pancreatic polypeptide (PP), somatostatin, leukocytes, B/T lymphocytes, B lymphocytes, T lymphocytes, macrophages/monocytes and mast cells. The densities of these endocrine and immune cells were quantified by computer‑aided image analysis. The densities of CgA-, serotonin-, PYY- and enteroglucagon-producing cells were significantly higher, and those of PP- and somatostatin-producing cells were significantly lower in the DSS‑G, DSS‑Q and control groups than in the DSS group. The densities of all the immune cells were lower in the DSS‑G, DSS‑Q and control groups than in the DSS group. The densities of all endocrine cell types and immune cells in both the DSS groups treated with anti‑inflammatory agents were restored to control levels. In conclusion, our data demonstrate that there is an interaction between endocrine and immune cells during inflammation. This interaction with subsequent changes in endocrine cells is responsible for the

  15. Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis.

    Science.gov (United States)

    Rajendran, Vazhaikkurichi M; Nanda Kumar, Navalpur S; Tse, Chung M; Binder, Henry J

    2015-10-16

    Diarrhea associated with ulcerative colitis (UC) occurs primarily as a result of reduced Na(+) absorption. Although colonic Na(+) absorption is mediated by both epithelial Na(+) channels (ENaC) and Na-H exchangers (NHE), inhibition of NHE-mediated Na(+) absorption is the primary cause of diarrhea in UC. As there are conflicting observations reported on NHE expression in human UC, the present study was initiated to identify whether NHE isoforms (NHE2 and NHE3) expression is altered and how Na(+) absorption is regulated in DSS-induced inflammation in rat colon, a model that has been used to study UC. Western blot analyses indicate that neither NHE2 nor NHE3 expression is altered in apical membranes of inflamed colon. Na(+) fluxes measured in vitro under voltage clamp conditions in controls demonstrate that both HCO3 (-)-dependent and butyrate-dependent Na(+) absorption are inhibited by S3226 (NHE3-inhibitor), but not by HOE694 (NHE2-inhibitor) in normal animals. In contrast, in DSS-induced inflammation, butyrate-, but not HCO3 (-)-dependent Na(+) absorption is present and is inhibited by HOE694, but not by S3226. These observations indicate that in normal colon NHE3 mediates both HCO3 (-)-dependent and butyrate-dependent Na(+) absorption, whereas DSS-induced inflammation activates NHE2, which mediates butyrate-dependent (but not HCO3 (-)-dependent) Na(+) absorption. In in vivo loop studies HCO3 (-)-Ringer and butyrate-Ringer exhibit similar rates of water absorption in normal rats, whereas in DSS-induced inflammation luminal butyrate-Ringer reversed water secretion observed with HCO3 (-)-Ringer to fluid absorption. Lumen butyrate-Ringer incubation activated NHE3-mediated Na(+) absorption in DSS-induced colitis. These observations suggest that the butyrate activation of NHE2 would be a potential target to control UC-associated diarrhea.

  16. Quantity and quality of drainage from the Argo Tunnel and other sources related to metal mining in Gilpin, Clear Creek and Park Counties, Colorado

    Science.gov (United States)

    Wentz, Dennis A.

    1977-01-01

    Eighteen metal-mine drainage sources have been located in that part of Gilpin, Clear Creek, and Park Counties, Colo., lying within the Missouri River basin. At least 13 of these sources are known to contain high acidity and (or) trace-element concentrations or to contribute water to adversely affected streams. From January 1976 to March 1977, drainage from the Argo Tunnel in Idaho Springs--one of the major metal-mine drainage sources in the study area--exhibited variations in discharge from 0.35 to 0.55 cubic feet per second (0.010 to 0.016 cubic meters per second), a relatively constant temperature of 16 degrees Celsius, and variations in specific conductance from 2,680 to 3,410 micromhos per centimeter at 25 degrees Celsius (though a value of about 3,100 micromhos persisted throughout most of the period of record). High, but relatively constant, total concentrations (in micrograms per liter) of arsenic (100 to 180), cadmium (140 to 170), copper (5,000 to 6,000), iron (160,000 to 200,000), lead (less than 100 to 200), manganese (80,000 to 110,000), and zinc (40,000 to 49,000) were measured in the Argo Tunnel drainage from March 1976 to March 1977. Except for lead, the trace elements were mostly dissolved (82 percent or greater) and appear to represent baseline concentrations. Long-term degradation of water flowing from the Argo Tunnel is shown by increases of at least 2.5 to 8.0 times for dissolved solids, dissolved iron, calcium, magnesium, and sulfate since 1906. The acidity has changed from neutral in 1906 to a median pH value of 2.9 in 1976-77. Comparison of current Argo Tunnel data with those collected previously by other investigators indicates that spring chemical flushes containing higher than baseline trace-element concentrations occurred in 1973 and 1974, but not in 1975 or 1976, and probably not in 1972. The spring chemical flushes appear to be associated with increased infiltration from snowmelt in the catchment of the Argo Tunnel. Because of the wide

  17. Bacterial Feeders, the Nematode Caenorhabditis elegans and the Flagellate Cercomonas longicauda, have different Effects on Outcome of Competition among the Pseudomonas Biocontrol Strains CHA0 and DSS73

    DEFF Research Database (Denmark)

    Pedersen, Annette; Nybroe, Ole; Winding, Anne;

    2009-01-01

    selective feeding flagellate Cercomonas longicauda versus the non-selective feeding nematode Caenorhabditis elegans) influence the abundance of two bacteria that compete for resources in simple model communities. Microcosms consisted of either one gfp-tagged bacterial strain (Pseudomonas fluorescens DSM......50090 or one of two biocontrol strains P. fluorescens CHA0 or Pseudomonas sp. DSS73) or combinations of two bacterial strains. DSM50090 is a suitable food bacterium, DSS73 is of intermediate food quality, and CHA0 is inedible to the bacterial feeders. Bacterial and protozoan cell numbers were measured......How bacterial feeding fauna affects colonization and survival of bacteria in soil is not well understood, which constrains the applicability of bacterial inoculants in agriculture. This study aimed to unravel how food quality of bacteria and bacterial feeders with different feeding habits (the...

  18. Penyusunan Panduan Pengelolaan Keamanan Informasi Untuk Firewall Configuration Berdasarkan Kerangka Kerja PCI DSS v.3.1 dan COBIT 5

    Directory of Open Access Journals (Sweden)

    Bagus Puji Santoso

    2016-10-01

    Full Text Available Information security systems must be protected from all attacks and interuptions by an unauthorized user. Firewall is a mechanism that can be applied to improve the security information which done by filtering data packets that enter and exit the network. IT governance is needed to manage good information security. IT governance can use to make the arrangement of guidelines for the management of information security. This research aims to create a reference guide to information security such as an information security management guide for firewall configuration that refers to the framework of PCI DSS v.3.1 and COBIT 5 by taking a case study at the DSIK Universitas Airlangga.Arrangement of guidelines for information security management for firewall configuration will be done in three stages. The first stage was the arrangement of information security management procedures for firewall configuration which consists of mapping analysis stage process, arrangement procedure’s stage and determining roles and job description’s stage. In the second stage was the verification of the information security management guidance using a questionnaire. The third stage was improvement of the information security management guidance. These improvements was done to correct deficiencies that were produced when verification. The verification results show that 42.86% of respondents said that management guidelines are operationally very easy to be implemented.

  19. 2-D Crustal thermal structure along Thuadara–Sindad DSS profile across Narmada– Son lineament, central India

    Indian Academy of Sciences (India)

    S N Rai; S Thiagarajan

    2007-08-01

    Central India is traversed by a WSW–ENE trending Narmada–Son lineament (NSL) which is characterized by the presence of numerous hot springs, feeder dykes for Deccan Traps and seismicity all along its length. It is divided in two parts by the Barwani–Sukta Fault (BSF). To the west of this fault a graben exists, whereas to the east the basement is uplifted between Narmada North Fault (NNF) and Narmada South Fault (NSF). The present work deals with the 2-D thermal modeling to delineate the crustal thermal structure of the western part of NSL region along the Thuadara–Sindad Deep Seismic Sounding (DSS) profile which runs almost in the N–S direction across the NSL. Numerical results of the model reveal that the conductive surface heat flow value in the region under consideration varies between 45 and 47mW/m2. Out of which 23mW/m2 is the contribution from the mantle heat flow and the remaining from within the crust. The Curie depth is found to vary between 46 and 47 km and is in close agreement with the earlier reported Curie depth estimated from the analysis of MAGSAT data. The Moho temperature varies between 470 and 500°C. This study suggests that this western part of central Indian region is characterized by low mantle heat flow which in turn makes the lower crust brittle and amenable to the occurrence of deep focused earthquakes such as Satpura (1938) earthquake.

  20. Evaluating the role of vegetation on the transport of contaminants associated with a mine tailing using the Phyto-DSS

    Energy Technology Data Exchange (ETDEWEB)

    Cano-Resendiz, Omar [Departamento de Ingenieria Quimica, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Rosa, Guadalupe de la, E-mail: delarosa@quijote.ugto.mx [Departamento de Ingenieria Quimica, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Cruz-Jimenez, Gustavo [Departamento de Farmacia, Universidad de Guanajuato, Noria Alta s/n, CP 36050 Guanajuato (Mexico); Gardea-Torresdey, Jorge L. [Chemistry Department and Environmental Science and Engineering, Ph.D. Program, The University of Texas at El Paso, 500 W. University Ave., 79968 El Paso, TX (United States); Robinson, Brett H. [Agriculture and Life Sciences, Lincoln University, P.O. Box 84 Lincoln, Canterbury 7646 (New Zealand)

    2011-05-15

    We identified contaminants associated with the Cata mine tailing depot located in the outskirts of the city of Guanajuato, Mexico. We also investigated strategies for their phytomanagement. Silver and antimony were present at 39 and 31 mg kg{sup -1}, respectively, some twofold higher than the Dutch Intervention Values. Total and extractable boron (B) occurred at concentrations of 301 and 6.3 mg L{sup -1}, respectively. Concentrations of B in soil solution above 1.9 mg L{sup -1} have been shown to be toxic to plants. Plant growth may also be inhibited by the low concentrations of extractable plant nutrients. Analysis of the aerial portions of Aloe vera (L. Burm.f.) revealed that this plant accumulates negligible concentrations of the identified contaminants. Calculations using a whole system model (Phyto-DSS) showed that establishing a crop of A. vera would have little effect on the drainage or leaching from the site. However, this plant would reduce wind and water erosion and potentially produce valuable cosmetic products. In contrast, crops of poplar, a species that is tolerant to high soil B concentrations, would mitigate leaching from this site. Alternate rows of trees could be periodically harvested and be used for timber or bioenergy.

  1. Reemergence of dengue virus type-3 (subtype-III in India: Implications for increased incidence of DHF & DSS

    Directory of Open Access Journals (Sweden)

    Tewari KN

    2006-07-01

    Full Text Available Abstract Background Dengue virus infection has recently taken endemic proportion in India implicating all the four known dengue serotypes. There was a major dengue outbreak in northern India including Delhi in October- December, 2003 and again in 2004. We have carried out a detailed investigation of the 2004 outbreak by Serosurveillance, RT-PCR, nested PCR, virus isolation and genotyping. We also report the molecular epidemiological investigation of these outbreaks. Results The serological investigation of 162 suspected serum samples using an in-house dengue dipstick ELISA revealed 11%-IgM, 51%-IgG and 38%-both IgM and IgG antibody positivity. The RT-PCR analysis revealed presence of dengue RNA in 17 samples. Further subtyping and genotyping by nested PCR and nucleotide sequencing of C-prM gene junction revealed the association of subtype III of dengue virus type 3 in the outbreak. Conclusion The sudden shifting and dominance of the dengue virus serotype-3 (subtype III replacing the earlier circulating serotype-2 (subtype IV is a point of major concern and may be attributed to increased incidence of DHF and DSS in India.

  2. Evaluating the role of vegetation on the transport of contaminants associated with a mine tailing using the Phyto-DSS.

    Science.gov (United States)

    Cano-Reséndiz, Omar; de la Rosa, Guadalupe; Cruz-Jiménez, Gustavo; Gardea-Torresdey, Jorge L; Robinson, Brett H

    2011-05-15

    We identified contaminants associated with the Cata mine tailing depot located in the outskirts of the city of Guanajuato, Mexico. We also investigated strategies for their phytomanagement. Silver and antimony were present at 39 and 31 mg kg(-1), respectively, some twofold higher than the Dutch Intervention Values. Total and extractable boron (B) occurred at concentrations of 301 and 6.3 mg L(-1), respectively. Concentrations of B in soil solution above 1.9 mg L(-1) have been shown to be toxic to plants. Plant growth may also be inhibited by the low concentrations of extractable plant nutrients. Analysis of the aerial portions of Aloe vera (L. Burm.f.) revealed that this plant accumulates negligible concentrations of the identified contaminants. Calculations using a whole system model (Phyto-DSS) showed that establishing a crop of A. vera would have little effect on the drainage or leaching from the site. However, this plant would reduce wind and water erosion and potentially produce valuable cosmetic products. In contrast, crops of poplar, a species that is tolerant to high soil B concentrations, would mitigate leaching from this site. Alternate rows of trees could be periodically harvested and be used for timber or bioenergy.

  3. Perancangan Tata Kelola Teknologi Informasi di BAPAPSI Pemkab Bandung Menggunakan framework COBIT 5 Pada Domain EDM dan DSS

    Directory of Open Access Journals (Sweden)

    Rati Amanda Fajrin

    2016-10-01

    Full Text Available Information technology has an important role to support the implementation of public information. Bandung regency government has one of the bodies, named BAPAPSI. The existing problems in BAPAPSI, especially in PPI are uneven internet network in all districts, bad internet connection, bad handling of the incident, and the procurement of servers that do not support the use of the application in BAPAPSI. Therefore, 7 lifecycle COBIT 5 methodology is used to solve the problems in BAPAPSI. COBIT 5 provides complete, comprehensive guidelines in helping organizations to achieve the effective use of IT. The first stage in this research is assess capability level, then the next stage are mapping governance objective, enterprise goals, IT Related Goals and IT Process on COBIT 5. So, the results are the priority process on EDM04 and DSS01 domain to be analyzed and to design procedure IT governance using COBIT 5. This research also recommends the target of organizational structure in accordance with the needs of the Bandung regency government.

  4. Discussing a New DSS Combined with Data Warehouse%综合数据仓库的新型决策支持系统

    Institute of Scientific and Technical Information of China (English)

    张新香

    2004-01-01

    本文针对传统DSS(决策支持系统)中存在的问题,提出了一种综合数据仓库的新型DSS框架,并分析其优点,同时介绍了新型DSS在现实中的应用,最后分析了DSS未来的发展趋势.

  5. The Synergic Anti-inflammatory Impact of Gleditsia sinensis Lam. and Lactobacillus brevis KY21 on Intestinal Epithelial Cells in a DSS-induced Colitis Model.

    Science.gov (United States)

    Kim, Younghoon; Koh, Ji Hoon; Ahn, Young Jun; Oh, Sejong; Kim, Sea Hun

    2015-01-01

    We investigated the synergic anti-inflammatory activity of Gleditsia sinensis Lam. (GS) extract and Lactobacillus brevis KY21 both in vitro and in vivo. Western blot analysis and immunostaining showed that AKT phosphorylation that increased by the exposure of LPS were significantly decreased by the presence of either GS extract or L. brevis KY21. In addition, p65 intracellular transport was critically inhibited by GS extract and L. brevis KY21. We further studied these effects using an in vivo dextran sulfate sodium (DSS)-induced mouse model. Body weight, food intake, and clinical scores were dramatically decreased after treatment with DSS, whereas these effects were palliated by the addition of GS extract and L. brevis KY21. Importantly, transcription of genes encoding pro-inflammatory cytokines including IL-1β, TNF-α, and IFN-γ in mesenteric lymph nodes (MLN) and the spleen were increased by DSS treatment, whereas they were inhibited by the presence of GS extract and L. brevis KY21.

  6. MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells.

    Science.gov (United States)

    Pan, Huaqin; Zhang, Guqin; Zhang, Lin; Wang, Wei; Shang, Jian; Wang, Xiaobing; Zhao, Qiu; Li, Jin

    2016-07-01

    Available evidence suggests that both dysregulated innate and adaptive immune pathways contribute to the aberrant intestinal inflammatory response in patients with inflammatory bowel disease (IBD). Myeloid Differentiation 1 (MD-1), also known as Lymphocyte Antigen 86 (Ly86), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signaling pathway. Previous studies showed that MD-1 may be involved in the (patho) physiological regulation of the innate immune system and inflammation. In this study, we reported for the first time that MD-1 mRNA expression was up-regulated in both human IBD patients and DSS-treated WT mice. We showed that MD-1(-/-) mice were less susceptible to the development of colitis than WT controls as demonstrated by significantly reduced weight loss, disease activity index, colon histological scores, cellular infiltration and expression of inflammatory mediators. In addition, mucosal barrier function seemed to be intact in response to the loss of MD-1. Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice. Taken together, our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of DSS colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of IBD.

  7. Aspectos relevantes dos SAD nas organizações: um estudo exploratório Relevant aspects from DSS in organizations: an empirical investigation

    Directory of Open Access Journals (Sweden)

    Adriana Zenaide Clericuzi

    2006-04-01

    Full Text Available A informação vem auxiliando as organizações a alcançarem seus objetivos num ambiente de crescente concorrência, exigindo delas rapidez, flexibilidade e alta percepção. A abrangência cada vez maior do uso dos Sistemas de Apoio à Decisão (SAD como suporte na solução de problemas tem como proposta o processamento de informação para reduzir a incerteza e resolver conflitos. Este artigo tem como objetivo fazer uma investigação sobre os SAD nas organizações brasileiras. Para tal, foi conduzida uma pesquisa exploratória e descritiva, sobre o assunto, foram utilizados questionários que investigaram os SAD nas empresas brasileiras e aspectos relevantes destes sistemas.Information is supporting organizations to reach theirs objectives. Competition is increasing in organizational environment, requiring capability, flexibility and high perception. Decision Support Systems (DSS are becoming greater as a tool for solution of problems, processing information to reduce uncertain in decision problems and deciding conflicts. The objective of this paper is reports a study about DSS in organizations. For such an empirical investigation of literature in DSS and an empirical research were done. Questionnaires had been used to investigate the relevant aspects of SAD in the Brazilian companies.

  8. Ethanol Extract of Cordyceps militaris Grown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

    Science.gov (United States)

    Park, Dong Ki; Park, Hye-Jin

    2013-01-01

    The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI) as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs) and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS) and tumor necrosis factor- (TNF-) α mRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs. PMID:23841050

  9. Ethanol Extract of Cordyceps militaris Grown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS- Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

    Directory of Open Access Journals (Sweden)

    Dong Ki Park

    2013-01-01

    Full Text Available The effect of Cordyceps militaris (CM grown on germinated soybeans (GSC in the inflammatory bowel disease (IBD model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS- induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS and tumor necrosis factor- (TNF- α mRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.

  10. Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis

    Directory of Open Access Journals (Sweden)

    Jing-Wei Mao

    2014-01-01

    Full Text Available The immunoregulation between dendritic cells (DCs and regulatory T cells (T-regs plays an important role in the pathogenesis of ulcerative colitis (UC. Recent research showed that Fms-like tyrosine kinase 3 (Flt3 and Flt3 ligand (Flt3L were involved in the process of DCs regulating T-regs. The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC. In this study, we observe the disease activity index (DAI and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis. Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103+MHCII+DCs and CD4+CD25+FoxP3+T-regs in DSS-induced colitis. Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.

  11. Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice

    Directory of Open Access Journals (Sweden)

    Corthier Gérard

    2007-07-01

    Full Text Available Abstract Background Human immune cells generate large amounts of reactive oxygen species (ROS throughout the respiratory burst that occurs during inflammation. In inflammatory bowel diseases, a sustained and abnormal activation of the immune system results in oxidative stress in the digestive tract and in a loss of intestinal homeostasis. We previously showed that the heterologous production of the Lactobacillus plantarum ATCC14431 manganese-dependant catalase (MnKat in Lb. casei BL23 successfully enhances its survival when exposed to oxidative stress. In this study, we evaluated the preventive effects of this antioxidative Lb. casei strain in a murine model of dextran sodium sulfate (DSS-induced moderate colitis. Results Either Lb. casei BL23 MnKat- or MnKat+ was administered daily to mice treated with DSS for 10 days. In contrast to control mice treated with PBS for which DSS induced bleeding diarrhea and mucosal lesions, mice treated with both Lb. casei strains presented a significant (p Conclusion No contribution of MnKat to the protective effect from epithelial damage has been observed in the tested conditions. In contrast, these results confirm the high interest of Lb. casei as an anti-inflammatory probiotic strain.

  12. Objective mapping of Argo data in the Weddell Gyre: a gridded dataset of upper ocean water properties

    Directory of Open Access Journals (Sweden)

    K. A. Reeve

    2015-06-01

    Full Text Available The Weddell Gyre plays a crucial role in the modification of climate by advecting heat poleward to the Antarctic ice shelves and by regulating the density of water masses that feed the lowest limb of the global ocean overturning circulation. However, our understanding of Weddell Gyre water mass properties is limited to regions of data availability, primarily along the Prime Meridian. The aim of this paper is to provide a dataset of the upper water column properties of the entire Weddell Gyre. Objective mapping was applied to Argo float data in order to produce spatially gridded, time composite maps of temperature and salinity for fixed pressure levels ranging from 50 to 2000 dbar, as well as temperature, salinity and pressure at the level of the sub-surface temperature maximum. While the data are currently too limited to incorporate time into the gridded structure, the data are extensive enough to produce maps of the entire region across three time composite periods (2002–2005, 2006–2009 and 2010–2013, which can be used to determine how representative conclusions drawn from data collected along general RV transect lines are on a gyre scale perspective. The work presented here represents the technical prerequisite in addressing climatological research questions in forthcoming studies. These data sets are available in netCDF format at doi:10.1594/PANGAEA.842876.

  13. Exclusive Muon-Neutrino Charged Current Muon Plus Any Number of Protons Topologies In ArgoNeuT

    Energy Technology Data Exchange (ETDEWEB)

    Partyka, Kinga Anna [Yale Univ., New Haven, CT (United States)

    2013-01-01

    Neutrinos remain among the least understood fundamental particles even after decades of study. As we enter the precision era o f neutrino measurements bigger and more sophisticated detectors have emerged. The leading candidate among them is a Liquid Argon Time Projection Chamber (LArTPC ) detector technology due to its bubble-like chamber imaging, superb background rejection and scalability. I t is a perfect candidate that w ill aim to answer the remaining questions of the nature o f neutrino and perhaps our existence. Studying neutrinos with a detector that employs detection via beautiful images o f neutrino interactions can be both illuminating and surprising. The analysis presented here takes the full advantage of the LArTPC power by exploiting the first topological analysis of charged current muon neutrino p + N p , muon and any number of protons, interactions with the ArgoNeuT LArTPC experiment on an argon target. The results presented here are the first that address the proton multiplicity at the vertex and the proton kinematics. This study also addresses the importance o f nuclear effects in neutrino interactions. Furthermore, the developed here reconstruction techniques present a significant step forward for this technology and can be employed in the future LArTPC detectors.

  14. The Argo Simulation: I. Quenching of Massive Galaxies at High Redshift as a Result of Cosmological Starvation

    CERN Document Server

    Feldmann, Robert

    2014-01-01

    Observations show a prevalence of high redshift galaxies with large stellar masses and predominantly passive stellar populations. A variety of processes have been suggested that could reduce the star formation in such galaxies to observed levels, including quasar mode feedback, virial shock heating, or galactic winds driven by stellar feedback. However, the main quenching mechanisms have yet to be identified. Here we study the origin of star formation quenching using Argo, a cosmological zoom-in simulation that follows the evolution of a massive galaxy at $z\\geq{}2$. This simulation adopts the same sub-grid recipes of the Eris simulations, which have been shown to form realistic disk galaxies, and, in one version, adopts also a mass and spatial resolution identical to Eris. The resulting galaxy has properties consistent with those of observed, massive (M_* ~ 1e11 M_sun) galaxies at z~2 and with abundance matching predictions. Our models do not include AGN feedback indicating that supermassive black holes like...

  15. Understanding Legacy Features with Featureous

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    Feature-centric comprehension of source code is essential during software evolution. However, such comprehension is oftentimes difficult to achieve due the discrepancies between structural and functional units of object-oriented programs. We present a tool for feature-centric analysis of legacy...

  16. Feature Extraction

    CERN Document Server

    CERN. Geneva

    2015-01-01

    Feature selection and reduction are key to robust multivariate analyses. In this talk I will focus on pros and cons of various variable selection methods and focus on those that are most relevant in the context of HEP.

  17. Site Features

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset consists of various site features from multiple Superfund sites in U.S. EPA Region 8. These data were acquired from multiple sources at different times...

  18. Solar Features

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of solar feature datasets contributed by a number of national and private solar observatories located worldwide.

  19. Finite-difference migration of the field of refracted waves in studies of the deep structure of the Earth's crust and the upper mantle based on the DSS (on the example of the DOBRE profile)

    Science.gov (United States)

    Pilipenko, V. N.; Verpakhovskaya, A. O.; Starostenko, V. I.; Pavlenkova, N. I.

    2010-11-01

    The main results of deep seismic sounding (DSS) are usually presented in the form of high-velocity models of the medium. Some model examples and the international DOBRE profile have shown that the informativeness of the data obtained can be significantly enhanced by the construction of wave images of the Earth’s crust, based on the migration of refracted and wide-angle reflected waves. The Donets Basin Refraction/Reflection Experiment ( DOBRE) profile crosses the Dnieper-Donets paleorift zone in the Donbas region. Along the profile, refracted waves from the basement and the upper mantle and the reflections from the crust basement (the M boundary) are reliably traced. This wave migration has been used to construct a wave image of the structure of the Earth’s crust. As a result, a clear seismic image of the basement surface, whose depth changes along the profile from 0 to 20 km, was obtained. In near-slope parts of the basin, several major faults were identified that had not been identified previously during standard kinematic data processing. It is shown that the crust-upper mantle transition zone is a clearly reflective horizon only within the crystalline massifs; under a depression, it is represented by a lens-shaped highly-heterogeneous area. As shown in the model examples, the images obtained using such a migration accurately reflect the structural features of the medium, in spite of its complicated structure.

  20. The ESPAT tool: a general-purpose DSS shell for solving stochastic optimization problems in complex river-aquifer systems

    Science.gov (United States)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel; Tilmant, Amaury

    2015-04-01

    Stochastic programming methods are better suited to deal with the inherent uncertainty of inflow time series in water resource management. However, one of the most important hurdles in their use in practical implementations is the lack of generalized Decision Support System (DSS) shells, usually based on a deterministic approach. The purpose of this contribution is to present a general-purpose DSS shell, named Explicit Stochastic Programming Advanced Tool (ESPAT), able to build and solve stochastic programming problems for most water resource systems. It implements a hydro-economic approach, optimizing the total system benefits as the sum of the benefits obtained by each user. It has been coded using GAMS, and implements a Microsoft Excel interface with a GAMS-Excel link that allows the user to introduce the required data and recover the results. Therefore, no GAMS skills are required to run the program. The tool is divided into four modules according to its capabilities: 1) the ESPATR module, which performs stochastic optimization procedures in surface water systems using a Stochastic Dual Dynamic Programming (SDDP) approach; 2) the ESPAT_RA module, which optimizes coupled surface-groundwater systems using a modified SDDP approach; 3) the ESPAT_SDP module, capable of performing stochastic optimization procedures in small-size surface systems using a standard SDP approach; and 4) the ESPAT_DET module, which implements a deterministic programming procedure using non-linear programming, able to solve deterministic optimization problems in complex surface-groundwater river basins. The case study of the Mijares river basin (Spain) is used to illustrate the method. It consists in two reservoirs in series, one aquifer and four agricultural demand sites currently managed using historical (XIV century) rights, which give priority to the most traditional irrigation district over the XX century agricultural developments. Its size makes it possible to use either the SDP or

  1. Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-treatment.

    Directory of Open Access Journals (Sweden)

    Asa Håkansson

    Full Text Available Long-term colonic inflammation promotes carcinogenesis and histological abnormalities of the liver, and colorectal tumours frequently arise in a background of dysplasia, a precursor of adenomas. Altered colonic microbiota with an increased proportion of bacteria with pro-inflammatory characteristics, have been implicated in neoplastic progression. The composition of the microbiota can be modified by dietary components such as probiotics, polyphenols and dietary fibres. In the present study, the influence of probiotics in combination with blueberry husks on colorectal carcinogenesis and subsequent liver damage was evaluated.Colorectal tumours were induced in rats by cyclic treatment with dextran sulphate sodium (DSS. Blueberry husks and a mixture of three probiotic strains (Bifidobacterium infantis DSM 15159, Lactobacillus gasseri, DSM 16737 and Lactobacillus plantarum DSM 15313 supplemented a basic diet fortified with oats. The condition of the rats was monitored using a disease activity index (DAI. A qualitative and quantitative histological judgement was performed on segments of distal colon and rectum and the caudate lobe of the liver. The formation of short-chain fatty acids, bacterial translocation, the inflammatory reaction and viable count of lactobacilli and Enterobaceriaceae were addressed.Blueberry husks with or without probiotics significantly decreased DAI, and significantly reduced the number of colonic ulcers and dysplastic lesions. With a decreased proportion of blueberry husk in the diet, the probiotic supplement was needed to achieve a significant decrease in numbers of dysplastic lesions. Probiotics decreased faecal viable count of Enterobacteriaceae and increased that of lactobacilli. Blueberry husks with or without probiotics lowered the proportion of butyric acid in distal colon, and decreased the haptoglobin levels. Probiotics mitigated hepatic injuries by decreasing parenchymal infiltration and the incidence of stasis and

  2. Search for GeV gamma-ray bursts with the ARGO-YBJ detector: summary of eight years of observations

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S.; Piazzoli, B. D' Ettorre; Di Girolamo, T. [Dipartimento di Fisica dell' Università di Napoli " Federico II," Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A.; De Mitri, I. [Dipartimento Matematica e Fisica " Ennio De Giorgi," Università del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Camarri, P. [Dipartimento di Fisica dell' Università di Roma " Tor Vergata," via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R.; Sciascio, G. Di [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Chen, T. L.; Danzengluobu [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z., E-mail: digirola@na.infn.it, E-mail: Piero.Vallania@to.infn.it, E-mail: vigorito@to.infn.it [Yunnan University, 2 North Cuihu Rd., 650091 Kunming, Yunnan (China); Collaboration: ARGO-YBJ Collaboration; and others

    2014-10-10

    The search for gamma-ray burst (GRB) emission in the energy range of 1-100 GeV in coincidence with the satellite detection has been carried out using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) experiment. The high-altitude location (4300 m a.s.l.), the large active surface (∼6700 m{sup 2} of Resistive Plate Chambers), the wide field of view (∼2 sr, limited only by the atmospheric absorption), and the high duty cycle (>86%) make the ARGO-YBJ experiment particularly suitable to detect short and unexpected events like GRBs. With the scaler mode technique, i.e., counting all the particles hitting the detector with no measurement of the primary energy and arrival direction, the minimum threshold of ∼1 GeV can be reached, overlapping the direct measurements carried out by satellites. During the experiment lifetime from 2004 December 17 to 2013 February 7, a total of 206 GRBs occurring within the ARGO-YBJ field of view (zenith angle θ ≤ 45°) have been analyzed. This is the largest sample of GRBs investigated with a ground-based detector. Two light curve models have been assumed and since in both cases no significant excess has been found, the corresponding fluence upper limits in the 1-100 GeV energy region have been derived, with values as low as 10{sup –5} erg cm{sup –2}. The analysis of a subset of 24 GRBs with known redshift has been used to constrain the fluence extrapolation to the GeV region together with possible cutoffs under different assumptions on the spectrum.

  3. Argos-Murcia : programa de prevención y atención del consumo de alcohol y otras drogas para Atención Primaria

    OpenAIRE

    Villar Lorenzo, Ana Belén

    2016-01-01

    OBJETIVO GENERAL: Capacitar a los Equipos de Atención Primaria de la Región de Murcia en la realización de intervenciones sistematizadas para la prevención, detección precoz y tratamiento de los diferentes problemas asociados con el consumo de alcohol y otras drogas, en coordinación con el resto de los niveles asistenciales y con los recursos educativos y comunitarios de cada zona de salud. METODOLOGÍA: Este programa consta de cuatro proyectos denominados: 1.- Proyecto ARGOS – AP: Actu...

  4. Towards closure of regional heat budgets in the North Atlantic using Argo floats and surface flux datasets

    Directory of Open Access Journals (Sweden)

    N. C. Wells

    2009-01-01

    Full Text Available The upper ocean heat budget (0–300 m of the North Atlantic from 20°–60° N is investigated using data from Argo profiling floats for 1999–2005 and the NCEP/NCAR and NOC surface flux datasets. Estimates of the different terms in the budget (heat storage, advection, diffusion and surface exchange are obtained using the methodology developed by Hadfield et al. (2007. The method includes optimal interpolation of the individual profiles to produce gridded fields with error estimates at a 10×10 degree grid box resolution. Closure of the heat budget is obtained within the error estimates for some regions – particularly the eastern subtropical Atlantic – but not for those boxes that include the Gulf Stream. Over the whole range considered, closure is obtained for 13 (9 out of 20 boxes with the NOC (NCEP/NCAR surface fluxes. The seasonal heat budget at 20°–30° N, 35°–25° W is considered in detail. Here, the NCEP based budget has an annual mean residual of -55±35 W m-2 compared with a NOC based value of -4±35 W m-2. For this box, the net heat divergence of 36 W m-2 (Ekman=-4 W m-2, geostrophic=11 W m-2, diffusion=29 W m-2 offsets the net heating of 32 W m-2 from the NOC surface heat fluxes. The results in this box are consistent with an earlier evaluation of the fluxes using measurements from research buoys in the subduction array which revealed biases in NCEP but good agreement of the buoy values with the NOC fields.

  5. Towards closure of regional heat budgets in the North Atlantic using Argo floats and surface flux datasets

    Directory of Open Access Journals (Sweden)

    N. C. Wells

    2009-04-01

    Full Text Available The upper ocean heat budget (0–300 m of the North Atlantic from 20°–60° N is investigated using data from Argo profiling floats for 1999–2005 and the NCEP/NCAR and NOC surface flux datasets. Estimates of the different terms in the budget (heat storage, advection, diffusion and surface exchange are obtained using the methodology developed by Hadfield et al. (2007a, b. The method includes optimal interpolation of the individual profiles to produce gridded fields with error estimates at a 10°×10° grid box resolution. Closure of the heat budget is obtained within the error estimates for some regions – particularly the eastern subtropical Atlantic – but not for those boxes that include the Gulf Stream. Over the whole range considered, closure is obtained for 13 (9 out of 20 boxes with the NOC (NCEP/NCAR surface fluxes. The seasonal heat budget at 20–30° N, 35–25° W is considered in detail. Here, the NCEP based budget has an annual mean residual of −55±35 Wm−2 compared with a NOC based value of −4±35 Wm−2. For this box, the net heat divergence of 36 Wm−2 (Ekman=−4 Wm−2, geostrophic=11 Wm−2, diffusion=29 Wm−2 offsets the net heating of 32 Wm−2 from the NOC surface heat fluxes. The results in this box are consistent with an earlier evaluation of the fluxes using measurements from research buoys in the subduction array which revealed biases in NCEP but good agreement of the buoy values with the NOC fields.

  6. Detailed temperature–salinity distribution in the Northeast Atlantic from ship and Argo vertical casts

    Directory of Open Access Journals (Sweden)

    I. Bashmachnikov

    2014-06-01

    Full Text Available The present study defines new interpolation functions for hydrological data. These functions are applied to generate climatological maps of temperature–salinity distribution with 25 m depth interval and 30 km space interval (MEDTRANS data-set. The data underwent a rigorous data quality control, having passed several filtering procedures. The gridding was done on neutral density surfaces, which allows better representation of the relative intensity of thermohaline fronts for the same gridding radius. The gridding was done using multi-pass Barnes' Optimum Interpolation procedure with spatially variable size of the gridding window. The shape of the window accounted for topographic influence: the dominant along-slope direction of water mass transport. One of the new features was the use of a local ratio of topographic to planetary β-effects to define the shape of the window as a function of the relative importance of the topographic influence. The N/f ratio was used for simulation of the baroclinic decrease of the topographic influence on water mass transport with the distance from the bottom. The gridded fields are available at the web-site of the Center of Oceanography of the University of Lisbon (http://co.fc.ul.pt/en/data. The new MEDTRANS climatology gives more details to the distribution of water characteristics in the Subtropical Northeast Atlantic, in particular near the Iberian Peninsula. The geostrophic currents relative to the 1900 m reference level demonstrate the local circulation features, in good correspondence to the theory and to previous studies: the acceleration in the meanders of the Azores current; the cyclonic gyre in the Gulf of Cadiz; the splitting and separation of the Mediterranean Water outflow from the continental slope near the Gorringe and the Galicia banks. Those features are not reproduced by the alternative climatologies. Seasonal climatologies, computed for the warm (May–October and cold (November

  7. Detailed temperature-salinity distribution in the Northeast Atlantic from ship and Argo vertical casts

    Science.gov (United States)

    Bashmachnikov, I.; Neves, F.; Nascimento, A.; Medeiros, J.; Ambar, I.; Dias, J.; Carton, X.

    2014-06-01

    The present study defines new interpolation functions for hydrological data. These functions are applied to generate climatological maps of temperature-salinity distribution with 25 m depth interval and 30 km space interval (MEDTRANS data-set). The data underwent a rigorous data quality control, having passed several filtering procedures. The gridding was done on neutral density surfaces, which allows better representation of the relative intensity of thermohaline fronts for the same gridding radius. The gridding was done using multi-pass Barnes' Optimum Interpolation procedure with spatially variable size of the gridding window. The shape of the window accounted for topographic influence: the dominant along-slope direction of water mass transport. One of the new features was the use of a local ratio of topographic to planetary β-effects to define the shape of the window as a function of the relative importance of the topographic influence. The N/f ratio was used for simulation of the baroclinic decrease of the topographic influence on water mass transport with the distance from the bottom. The gridded fields are available at the web-site of the Center of Oceanography of the University of Lisbon (http://co.fc.ul.pt/en/data). The new MEDTRANS climatology gives more details to the distribution of water characteristics in the Subtropical Northeast Atlantic, in particular near the Iberian Peninsula. The geostrophic currents relative to the 1900 m reference level demonstrate the local circulation features, in good correspondence to the theory and to previous studies: the acceleration in the meanders of the Azores current; the cyclonic gyre in the Gulf of Cadiz; the splitting and separation of the Mediterranean Water outflow from the continental slope near the Gorringe and the Galicia banks. Those features are not reproduced by the alternative climatologies. Seasonal climatologies, computed for the warm (May-October) and cold (November-April) seasons, revealed stronger

  8. IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice.

    Science.gov (United States)

    Wang, Yuanyuan; Jiang, Xuefeng; Zhu, Junfeng; Dan Yue; Zhang, Xiaoqing; Wang, Xiao; You, Yong; Wang, Biao; Xu, Ying; Lu, Changlong; Sun, Xun; Yoshikai, Yasunobu

    2016-08-22

    Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD is not very clear. In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that IL-21R.KO mice were more susceptible to DSS-induced colitis as compared with C57BL/6 mice. The spontaneous inflammatory cytokines released by macrophages in LP of colon were significantly increased, and Th2, Th17 and Treg responses were down-regulated markedly. However, Th1 responses were significantly up-regulated in IL-21R.KO mice. Meanwhile, the population of CD8(+)CD44(+)IFN-γ(+) T cells was markedly elevated in LP of inflammatory intestine of IL-21RKO mice. In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and Treg responses in mice. Therefore, therapeutic manipulation of IL-21/IL-21R activity may allow improved immunotherapy for IBD and other inflammatory diseases associated with Th cell responses.

  9. MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.

    Science.gov (United States)

    Liu, Wen; Guo, Wenjie; Hang, Nan; Yang, Yuanyuan; Wu, Xuefeng; Shen, Yan; Cao, Jingsong; Sun, Yang; Xu, Qiang

    2016-05-24

    Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-κB) activation, plays an important role in innate and adaptive immunity. Suppression of MALT1 protease activity with small molecule inhibitors showed promising efficacies in subtypes of B cell lymphoma and improvement in experimental autoimmune encephalomyelitis model. However, whether MALT1 inhibitors could ameliorate colitis remains unclear. In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-κB and NLRP3 inflammasome activation. Treatment with MI-2 and mepazine dose-dependently attenuated symptoms of colitis in mice, evidenced by reduction in the elevated disease activity index, the shortening of colon length as well as the histopathologic improvement. Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF, IL-1β, IL-6, IL-18, IL-17A and IFN-γ, were markedly suppressed by MALT1 inhibitors. The underlying mechanisms for the protective effect of MALT1 inhibitors in DSS-induced colitis may be attributed to its inhibition on NF-κB and NLRP3 inflammasome activation in macrophages. The in vitro study showed that MALT1 inhibitors decreased production of IL-1β/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-κB and NLRP3 inflammasome. Taken together, our results demonstrated that inhibition of the protease activity of MALT1 might be a viable strategy to treat inflammatory bowel disease and the NLRP3 inflammasome and NF-κB activation are critical components in MALT1 signaling cascades in this disease model.

  10. Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice.

    Science.gov (United States)

    Sánchez-Fidalgo, Susana; Villegas, Isabel; Aparicio-Soto, Marina; Cárdeno, Ana; Rosillo, Ma Ángeles; González-Benjumea, Alejandro; Marset, Azucena; López, Óscar; Maya, Inés; Fernández-Bolaños, José G; Alarcón de la Lastra, Catalina

    2015-05-01

    Hydroxytyrosol, a polyphenolic compound from extra virgin olive oil (EVOO) has exhibited an improvement in a model of DSS-induced colitis. However, other phenolic compounds present such as hydroxytyrosyl acetate (HTy-Ac) and 3,4-dihydroxyphenylglycol (DHPG) need to be explored to complete the understanding of the overall effects of EVOO on inflammatory colon mucosa. This study was designed to evaluate the effect of both HTy-Ac and DHPG dietary supplementation in the inflammatory response associated to colitis model. Six-week-old mice were randomized in four dietary groups: sham and control groups received standard diet, and other two groups were fed with HTy-Ac and DHPG, respectively, at 0.1%. After 30 days, all groups except sham received 3% DSS in drinking water for 5 days followed by a regime of 5 days of water. Acute inflammation was evaluated by Disease Activity Index (DAI), histology and myeloperoxidase (MPO) activity. Colonic expression of iNOS, COX-2, MAPKs, NF-kB and FOXP3 were determined by western blotting. Only HTy-Ac-supplemented group showed a significant DAI reduction as well as an improvement of histological damage and MPO. COX-2 and iNOS protein expression were also significantly reduced. In addition, this dietary group down-regulated JNK phosphorylation and prevented the DSS-induced nuclear translocation level of p65. However, no significant differences were observed in the FOXP3 expression. These results demonstrated, for the first time, that HTy-Ac exerts an antiinflammatory effect on acute ulcerative colitis. We concluded that HTy-Ac supplement might provide a basis for developing a new dietary strategy for the prevention of ulcerative colitis.

  11. DSS in Educational Organizations.

    Science.gov (United States)

    Telem, Moshe

    1990-01-01

    Describes the development of an educational decision support system (EDSS) in Israeli schools. The Israeli educational system is described, the integration of computers into school administration is discussed, the use of management information systems (MIS) is explained, and a structural framework for the implementation of an EDSS is presented.…

  12. DSS FOR ORGANIZATIONAL DIAGNOSIS

    NARCIS (Netherlands)

    FROWEIN, JC; POSTMA, TJBM

    1992-01-01

    Information technology in relation to organizational diagnosis and organizational change is the subject of extensive and increasing discussion. A condition for change is insight into organizational problems. This paper discusses the relation between the concepts ''problem'', ''decision making'' and

  13. Detection of thermal neutrons with the PRISMA-YBJ array in extensive air showers selected by the ARGO-YBJ experiment

    Science.gov (United States)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Stenkin, Yu. V.; Alekseenko, V. V.; Aynutdinov, V.; Cai, Z. Y.; Guo, X. W.; Liu, Y.; Rulev, V.; Shchegolev, O. B.; Stepanov, V.; Volchenko, V.; Zhang, H.

    2016-08-01

    We report on a measurement of thermal neutrons, generated by the hadronic component of extensive air showers (EAS), by means of a small array of EN-detectors developed for the PRISMA project (PRImary Spectrum Measurement Array), novel devices based on a compound alloy of ZnS(Ag) and 6LiF. This array has been operated within the ARGO-YBJ experiment at the high altitude Cosmic Ray Observatory in Yangbajing (Tibet, 4300 m a.s.l.). Due to the tight correlation between the air shower hadrons and thermal neutrons, this technique can be envisaged as a simple way to estimate the number of high energy hadrons in EAS. Coincident events generated by primary cosmic rays of energies greater than 100 TeV have been selected and analyzed. The EN-detectors have been used to record simultaneously thermal neutrons and the air shower electromagnetic component. The density distributions of both components and the total number of thermal neutrons have been measured. The correlation of these data with the measurements carried out by ARGO-YBJ confirms the excellent performance of the EN-detector.

  14. Sensitivity study of (10,100) GeV gamma-ray bursts with double shower front events from ARGO-YBJ

    Science.gov (United States)

    Zhou, Xun-Xiu; Gao, Lan-Lan; Zhang, Yu; Guo, Yi-Qing; Zhu, Qing-Qi; Jia, Huan-Yu; Huang, Dai-Hui

    2016-07-01

    ARGO-YBJ, located at the Yangbajing Cosmic Ray Observatory (4300 m a.s.l., Tibet, China), is a full coverage air shower array, with an energy threshold of ∼300 GeV for gamma-ray astronomy. Most of the recorded events are single front showers, satisfying the trigger requirement of at least 20 particles detected in a given time window. However, in ∼11.5% of the events, two randomly arriving showers may be recorded in the same time window, and the second one, generally smaller, does not need to satisfy the trigger condition. These events are called double shower front events. By using these small showers, well under the trigger threshold, the detector primary energy threshold can be lowered to a few tens of GeV. In this paper, the angular resolution that can be achieved with these events is evaluated by a full Monte Carlo simulation. The ARGO-YBJ sensitivity in detecting gamma-ray bursts (GRBs) by using double shower front events is also studied for various cutoff energies, time durations, and zenith angles of GRBs in ARGO’s field of view. Supported by National Natural Science Foundation of China (11475141) and Fundamental Research Funds for Central Universities (2682014CX091)

  15. 4.5-year simultaneous multi-wavelength observation of Mrk 421 in the ARGO-YBJ and Fermi overlap era

    CERN Document Server

    Chen, Songzhan

    2015-01-01

    As one of the most active blazars, Mrk421 is an excellent candidate for the study of the physical processes within the jets of AGN. Here we report on the extensive multi-wavelength observations of Mrk 421 over 4.5 years, from 2008 August to 2013 February. This source was simultaneously monitored by several experiments at different wavelengths: ARGO-YBJ in TeV $\\gamma$-rays, $Fermi$-LAT in GeV $\\gamma$-rays, $Swift$-BAT in hard X-rays, $RXTE$-ASM, $MAXI$ and $Swift$-XRT in soft X-rays, $Swift$-UVOT in ultraviolet, and OVRO in radio frequencies. In particular, thanks to the ARGO-YBJ and $Fermi$ data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. According to the observed light curves, ten states (including seven large flares, two quiescent phases and one outburst) were selected. For the first time, the multi-wavelength spectral evolutions of Mrk 421 during different states were systematically analyzed. During the outburst phase and the seven flaring episodes, the peak energy in X-ray...

  16. 4.5 years multi-wavelength observations of Mrk 421 during the ARGO-YBJ and Fermi common operation time

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; Damone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q

    2016-01-01

    We report on the extensive multi-wavelength observations of the blazar Markarian 421 (Mrk 421) covering radio to gamma-rays, during the 4.5 year period of ARGO-YBJ and Fermi common operation time, from August 2008 to February 2013. In particular, thanks to the ARGO-YBJ and Fermi data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. In the observation period, Mrk 421 showed both low and high activity states at all wavebands. The correlations among flux variations in different wavebands were analyzed. Seven large flares, including five X-ray flares and two GeV gamma-ray flares with variable durations (3-58 days), and one X-ray outburst phase were identified and used to investigate the variation of the spectral energy distribution with respect to a relative quiescent phase. During the outburst phase and the seven flaring episodes, the peak energy in X-rays is observed to increase from sub-keV to few keV. The TeV gamma-ray flux increases up to 0.9-7.2 times the flux of the Crab Nebula. T...

  17. Observation of TeV gamma-rays from the unidentified source HESS J1841-055 with the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Bolognino, I; Branchini, P; Budano, A; Melcarne, A K Calabrese; Camarri, P; Cao, Z; Cardarelli, R; Catalanotti, S; Cattaneo, C; Chen, S Z; Chen, T L; Chen, Y; Creti, P; Cui, S W; Dai, B Z; Staiti, G DAli; DAmone, A; Danzengluobu,; De Mitri, I; Piazzoli, B DEttorre; Di Girolamo, T; Ding, X H; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F; Giroletti, E; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Huang, Q; Iacovacci, M; Iuppa, R; James, I; Jia, H Y; Labaciren,; Li, H J; Li, J Y; Li, X X; Liguori, G; Liu, C; Liu, C Q; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Martello, D; Mastroianni, S; Montini, P; Ning, C C; Pagliaro, A; Panareo, M; Panico, B; Perrone, L; Pistilli, P; Ruggieri, F; Salvini, P; Santonico, R; Sbano, S N; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, B; Wang, H; Wu, C Y; Wu, H R; Xu, B; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, Jilong; Zhang, Jianli; Zhang, L; Zhang, P; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Zizzi, G

    2013-01-01

    We report the observation of a very high energy \\gamma-ray source, whose position is coincident with HESS J1841-055. This source has been observed for 4.5 years by the ARGO-YBJ experiment from November 2007 to July 2012. Its emission is detected with a statistical significance of 5.3 standard deviations. Parameterizing the source shape with a two-dimensional Gaussian function we estimate an extension \\sigma=(0.40(+0.32,-0.22}) degree, consistent with the HESS measurement. The observed energy spectrum is dN/dE =(9.0-+1.6) x 10^{-13}(E/5 TeV)^{-2.32-+0.23} photons cm^{-2} s^{-1} TeV^{-1}, in the energy range 0.9-50 TeV. The integral \\gamma-ray flux above 1 TeV is 1.3-+0.4 Crab units, which is 3.2-+1.0 times the flux derived by HESS. The differences in the flux determination between HESS and ARGO-YBJ, and possible counterparts at other wavelengths are discussed.

  18. Simulation study on double front shower events and sensitivity of (10,100) GeV gamma-ray bursts from ARGO-YBJ

    CERN Document Server

    Zhou, Xunxiu; Zhang, Yu; Guo, Yiqing; Zhu, Qingqi; Jia, Huanyu; Huang, Daihui

    2015-01-01

    ARGO-YBJ, located at the YangBaJing Cosmic Ray Observatory (4300 m a.s.l., Tibet, China), is a full coverage air shower array, with an energy threshold of 300 GeV for gamma-ray astronomy. Most of the recorded events are single front showers, satisfying the trigger requirement of at least 20 particles detected in a given time window. However, in 13% of the events, two randomly arriving showers may be recorded in the same time window, and the second one, in generally smaller, does not need to satisfy the trigger condition. These events are called double front shower events. By using these small showers, well under the trigger threshold, the detector primary energy threshold can be lowered to a few tens of GeV. In this paper, the angular resolution that can be achieved with these events is evaluated by a full Monte Carlo simulation. The ARGO-YBJ sensitivity in detecting gamma-ray bursts (GRBs) by using double front shower events is also studied for various cutoff energies, time durations, and zenith angles of GR...

  19. OBSERVATION OF TeV GAMMA RAYS FROM THE UNIDENTIFIED SOURCE HESS J1841-055 WITH THE ARGO-YBJ EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Bartoli, B.; Catalanotti, S. [Dipartimento di Fisica dell' Universita di Napoli ' ' Federico II' ' , Complesso Universitario di Monte Sant' Angelo, via Cinthia, I-80126 Napoli (Italy); Bernardini, P.; D' Amone, A. [Dipartimento Matematica e Fisica ' ' Ennio De Giorgi' ' , Universita del Salento, via per Arnesano, I-73100 Lecce (Italy); Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, 100049 Beijing (China); Bolognino, I. [Dipartimento di Fisica dell' Universita di Pavia, via Bassi 6, I-27100 Pavia (Italy); Branchini, P.; Budano, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Calabrese Melcarne, A. K. [Istituto Nazionale di Fisica Nucleare-CNAF, Viale Berti-Pichat 6/2, I-40127 Bologna (Italy); Camarri, P. [Dipartimento di Fisica dell' Universita di Roma ' ' Tor Vergata' ' , via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cardarelli, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, via della Ricerca Scientifica 1, I-00133 Roma (Italy); Cattaneo, C. [Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, via Bassi 6, I-27100 Pavia (Italy); Chen, T. L. [Tibet University, 850000 Lhasa, Xizang (China); Creti, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, via per Arnesano, I-73100 Lecce (Italy); Cui, S. W. [Hebei Normal University, Shijiazhuang 050016, Hebei (China); Dai, B. Z. [Yunnan University, 2 North Cuihu Road, 650091 Kunming, Yunnan (China); D' Ali Staiti, G., E-mail: chensz@ihep.ac.cn [Dipartimento di Fisica, Universita degli Studi di Palermo, Viale delle Scienze, Edificio 18, I-90128 Palermo (Italy); Collaboration: ARGO-YBJ Collaboration; and others

    2013-04-20

    We report the observation of a very high energy {gamma}-ray source whose position is coincident with HESS J1841-055. This source has been observed for 4.5 years by the ARGO-YBJ experiment from 2007 November to 2012 July. Its emission is detected with a statistical significance of 5.3 standard deviations. Parameterizing the source shape with a two-dimensional Gaussian function, we estimate an extension {sigma}=(0.40{sup +0.32}{sub -0.22}){sup o}, which is consistent with the HESS measurement. The observed energy spectrum is dN/dE = (9.0 {+-} 1.6) Multiplication-Sign 10{sup -13}(E/5 TeV){sup -2.32{+-}0.23} photons cm{sup -2} s{sup -1} TeV{sup -1}, in the energy range 0.9-50 TeV. The integral {gamma}-ray flux above 1 TeV is 1.3 {+-} 0.4 Crab, which is 3.2 {+-} 1.0 times the flux derived by HESS. The differences in the flux determination between HESS and ARGO-YBJ and possible counterparts at other wavelengths are discussed.

  20. Component-based Design and Implementation of DSS' Model%基于组件技术的DSS模型设计与实现

    Institute of Scientific and Technical Information of China (English)

    赵会群; 鄢仁祥; 高远

    2000-01-01

    决策支持系统(DSS)是模型驱动的,DSS中模型的设计与实现是一个有待进一步研究的问题.该文把组件技术引入到DSS模型的设计与实现中,提出基于组件技术的DSS模型设计与实现策略,给出基于组件思想的DSS模型定义和运算,并描述基于组件技术的DSS基模型和复合模型的实现方法.

  1. The effect of all-trans retinoic acid at varying dose in the treatment of DSS-induced colitis in mice%不同剂量全反式维甲酸对DSS诱导小鼠肠炎的治疗作用

    Institute of Scientific and Technical Information of China (English)

    冯锦山; 邓颖; 杨正; 叶石才; 朱宇珍; 叶营

    2016-01-01

    目的 探讨不同剂量全反式维甲酸(AtRA)对葡聚糖硫酸钠(DSS)诱导结肠炎小鼠的治疗作用.方法 实验小鼠随机分为四组:对照组(Control组),模型组(DSS组),低剂量AtRA(DSS+AtRA-L)组,高剂量AtRA(DSS+AtRA-H)组,每组8只.除Control组外,其他组小鼠自由饮用3%DSS溶液7d诱导结肠炎.DSS+AtRA-L组和DSS+AtRA-H组分别给予AtRA 15 mg/kg和30 mg/kg腹腔注射8~14d.每天记录小鼠改良疾病活动指数(mDAI).第15天处死小鼠,测定各组小鼠结肠长度、结肠组织学评分、血清及结肠组织TNF-α水平.结果DSS+AtRA-H和DSS+AtRA-L组的mDAI和结肠组织学评分较DSS组降低,结肠长度则较DSS组增加,差异均有统计学意义(P<0.01或0.05).DSS+AtRA-H组和DSS+AtRA-L组的黏膜结构改善不明显,其结肠组织学评分高于Control组(P<0.01).DSS+AtRA-H组和DSS+AtRA-L组的TNF-α免疫组化评分比DSS组显著降低(P<0.01),DSS+AtRA-L组高于Control组(P<0.01),但DSS+AtRA-H组与Control组差异无统计学意义(P>0.05).DSS+AtRA-H组和DSS+AtRA-L组的血清TNF-α水平均比DSS组降低(P<0.01),但仍高于Control组(P<0.01).结论AtRA对DSS诱导的小鼠结肠炎有疗效,治疗作用呈剂量依赖关系,但其在肠黏膜结构和结肠缩短方面存在不同程度的局限性.

  2. Temperature-salinity distribution in the northeastern Atlantic from ship and Argo vertical casts

    Science.gov (United States)

    Bashmachnikov, I.; Neves, F.; Nascimento, Â.; Medeiros, J.; Ambar, I.; Dias, J.; Carton, X.

    2015-03-01

    The present study defines new interpolation functions for hydrological data. These functions are applied to generate climatological maps of temperature-salinity distribution with a 25 m depth interval and a 30 km space interval (MEDTRANS data set). The data undergo rigorous initial data quality control, having passed several filtering procedures. The gridding is done on neutral density surfaces, which allows better representation of thermohaline fronts for the same gridding radius. The multi-pass Barnes optimum interpolation procedure with spatially variable size of the gridding window is used. The shape of the window accounts for the dominant along-isobath direction of water mass transport over steeply sloping topography. A local ratio of topographic to planetary β-effects is used to define the shape of the window as a function of the relative importance of the topographic influence. The N/f ratio is applied to account for the baroclinic compensation decay of the topographic influence on water mass transport with the distance from the bottom. The gridded fields are available at the website of the Centre of Oceanography of the University of Lisbon (http://co.fc.ul.pt/en/data). The MEDTRANS climatology gives more details of the distribution of water characteristics in the subtropical northeastern Atlantic than other alternative climatologies and is able to reproduce a number of dynamic features described in the literature: the acceleration in the meanders of the Azores current; the cyclonic gyre in the Gulf of Cadiz; and the splitting and separation of the Mediterranean Water (MW) outflow in two veins near the Gorringe and Galicia banks. Seasonal climatologies, computed for the warm (May-October) and cold (November-April) seasons, reveal stronger zonal extension of the upper ocean patterns during the warm season, as compared to the cold one.

  3. Featuring animacy

    Directory of Open Access Journals (Sweden)

    Elizabeth Ritter

    2015-01-01

    Full Text Available Algonquian languages are famous for their animacy-based grammatical properties—an animacy based noun classification system and direct/inverse system which gives rise to animacy hierarchy effects in the determination of verb agreement. In this paper I provide new evidence for the proposal that the distinctive properties of these languages is due to the use of participant-based features, rather than spatio-temporal ones, for both nominal and verbal functional categories (Ritter & Wiltschko 2009, 2014. Building on Wiltschko (2012, I develop a formal treatment of the Blackfoot aspectual system that assumes a category Inner Aspect (cf. MacDonald 2008, Travis 1991, 2010. Focusing on lexical aspect in Blackfoot, I demonstrate that the classification of both nouns (Seinsarten and verbs (Aktionsarten is based on animacy, rather than boundedness, resulting in a strikingly different aspectual system for both categories. 

  4. The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.

    Science.gov (United States)

    Zou, Z; Zuo, D; Yang, J; Fan, H

    2016-09-01

    Inflammatory bowel disease (IBD) arises when intestinal immune homeostasis is broken, the maintenance of such homeostasis is principally controlled by cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). IECs can prevent the contact between luminal bacteria with immune cells through the formation of a physical barrier and the expression of antimicrobial peptides to maintain intestinal immune homeostasis. During Colitis the IECs can express increased ANXA1, which is important for regeneration of intestinal mucosa and function as a potent anti-inflammatory protein. Natural Killer (NK) cells can also suppress the progression of colitis. It is uncertain about the effect of the cross-talk between injured IECs and recruited NK cells during colitis. In this study, the expression of ANXA1 in IECS from DSS treated mice was increased, and more NK cells were recruited to intestinal mucosa. In addition, the expression of NKG2A was upregulated when co-cultured with NK cells. The results further proved that overexpression of NKG2A in NK cells was important for inhibiting the recruitment and activity of neutrophils to alleviate DSS-induced colitis. Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.

  5. In-Depth Analysis of Exoproteomes from Marine Bacteria by Shotgun Liquid Chromatography-Tandem Mass Spectrometry: the Ruegeria pomeroyi DSS-3 Case-Study

    Directory of Open Access Journals (Sweden)

    Jean Armengaud

    2010-07-01

    Full Text Available Microorganisms secrete into their extracellular environment numerous compounds that are required for their survival. Many of these compounds could be of great interest for biotechnology applications and their genes used in synthetic biology design. The secreted proteins and the components of the translocation systems themselves can be scrutinized in-depth by the most recent proteomic tools. While the secretomes of pathogens are well-documented, those of non-pathogens remain largely to be established. Here, we present the analysis of the exoproteome from the marine bacterium Ruegeria pomeroyi DSS-3 grown in standard laboratory conditions. We used a shotgun approach consisting of trypsin digestion of the exoproteome, and identification of the resulting peptides by liquid chromatography coupled to tandem mass spectrometry. Three different proteins that have domains homologous to those observed in RTX toxins were uncovered and were semi-quantified as the most abundantly secreted proteins. One of these proteins clearly stands out from the catalogue, representing over half of the total exoproteome. We also listed many soluble proteins related to ABC and TRAP transporters implied in the uptake of nutrients. The Ruegeria pomeroyi DSS-3 case-study illustrates the power of the shotgun nano-LC-MS/MS strategy to decipher the exoproteome from marine bacteria and to contribute to environmental proteomics.

  6. Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice.

    Science.gov (United States)

    Jo, Sung-Gang; Noh, Eui-Jeong; Lee, Jun-Young; Kim, Green; Choi, Joo-Hee; Lee, Mo-Eun; Song, Jung-Hee; Chang, Ji-Yoon; Park, Jong-Hwan

    2016-07-01

    Probiotics such as lactobacilli and bifidobacteria have healthpromoting effects by immune modulation. In the present study, we examined the immunomodulatory properties of Lactobacillus curvatus WiKim38, which was newly isolated from baechu (Chinese cabbage) kimchi. The ability of L. curvatus WiKim38 to induce cytokine production in bone marrow-derived dendritic cells (BMDCs) was determined by enzyme-linked immunosorbent assay. To evaluate the molecular mechanisms underlying L. curvatus Wikim38-mediated IL-10 production, Western blot analyses and inhibitor assays were performed. Moreover, the in vivo anti-inflammatory effects of L. curvatus WiKim38 were examined in a dextran sodium sulfate (DSS)-induced colitis mouse model. L. curvatus WiKim38 induced significantly higher levels of IL-10 in BMDCs compared with that induced by LPS. NF-κB and ERK were activated by L. curvatus WiKim38, and an inhibitor assay revealed that these pathways were required for L. curvatus WiKim38-induced production of IL-10 in BMDCs. An in vivo experiment showed that oral administration of L. curvatus WiKim38 increased the survival rate of mice with DSS-induced colitis and improved clinical signs and histopathological severity in colon tissues. Taken together, these results indicate that L. curvatus Wikim38 may have health-promoting effects via immune modulation, and may thus be applicable for therapy of various inflammatory diseases.

  7. A web-based spatial decision supporting system (S-DSS) for grapevine quality: the viticultural tool of the SOILCONS-WEB Project

    Science.gov (United States)

    Manna, Piero; Bonfante, Antonello; Basile, Angelo; Langella, Giuliano; Agrillo, Antonietta; De Mascellis, Roberto; Florindo Mileti, Antonio; Minieri, Luciana; Orefice, Nadia; Terribile, Fabio

    2014-05-01

    The SOILCONSWEB Project aims to create a decision support system operating at the landscape scale (Spatial-DSS) for the protection and the management of soils in both agricultural and environmental issues; it is a cyber-infrastructure built on remote servers operating through the web at www.landconsultingweb.eu. It includes - among others - a series of tools specifically designed to a Viticulture aiming at high quality wines production. The system is realized thanks to a collaboration between the University of Naples Federico II, CNR ISAFoM, Ariespace srl and SeSIRCA-Campania Region within a 5-years LIFE+ project funded by European Community. The system includes tools based on modelling procedures at different level of complexity some of which specifically designed for viticulture issues. One of the implemented models arise from the original desktop based SWAP model (Kroes et al, 2008). It can be run "on the fly" through a very user friendly web-interface. The specific tool, thanks to the model based on the Richard's equation can produce data on vineyard water stress, simulating the soil water balances of the different soil types within an area of interest. Thanks to a specific program developed within the project activities, the Spatial-DSS every day acquires punctual weather data and automatically spatialize them with geostatistical approaches in order to use the data as input for the SPA (Soil Plant Atmosphere ) model running. In particular for defining the upper boundary condition (rainfall and temperatures to estimate ET0 by the Hargraves model). Soil hydraulic properties (47 soil profiles within the study area), also essential for modelling simulation, were measured in laboratory using the Wind's approach or estimated through HYPRES PTF. Water retention and hydraulic conductivity relationships were parameterized according to the van Genuchten-Mualem model; Decision makers (individuals, groups of interests and public bodies) through the DSS can have real

  8. Temperature profile and other data collected using bottle and CTD casts from the ARGO and other platforms from the Coastal Waters of California during the California Cooperative Fisheries Investigation (CALCOFI) project, 16 March 1964 to 20 December 1964 (NODC Accession 7600333)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic Station Data, temperature, and other data were collected using CTD and bottle casts from ARGO and other platforms in the Coastal Waters of California...

  9. Sub-basin-scale sea level budgets from satellite altimetry, Argo floats and satellite gravimetry: a case study in the North Atlantic Ocean

    Science.gov (United States)

    Kleinherenbrink, Marcel; Riva, Riccardo; Sun, Yu

    2016-11-01

    In this study, for the first time, an attempt is made to close the sea level budget on a sub-basin scale in terms of trend and amplitude of the annual cycle. We also compare the residual time series after removing the trend, the semiannual and the annual signals. To obtain errors for altimetry and Argo, full variance-covariance matrices are computed using correlation functions and their errors are fully propagated. For altimetry, we apply a geographically dependent intermission bias [Ablain et al.(2015)], which leads to differences in trends up to 0.8 mm yr-1. Since Argo float measurements are non-homogeneously spaced, steric sea levels are first objectively interpolated onto a grid before averaging. For the Gravity Recovery And Climate Experiment (GRACE), gravity fields full variance-covariance matrices are used to propagate errors and statistically filter the gravity fields. We use four different filtered gravity field solutions and determine which post-processing strategy is best for budget closure. As a reference, the standard 96 degree Dense Decorrelation Kernel-5 (DDK5)-filtered Center for Space Research (CSR) solution is used to compute the mass component (MC). A comparison is made with two anisotropic Wiener-filtered CSR solutions up to degree and order 60 and 96 and a Wiener-filtered 90 degree ITSG solution. Budgets are computed for 10 polygons in the North Atlantic Ocean, defined in a way that the error on the trend of the MC plus steric sea level remains within 1 mm yr-1. Using the anisotropic Wiener filter on CSR gravity fields expanded up to spherical harmonic degree 96, it is possible to close the sea level budget in 9 of 10 sub-basins in terms of trend. Wiener-filtered Institute of Theoretical geodesy and Satellite Geodesy (ITSG) and the standard DDK5-filtered CSR solutions also close the trend budget if a glacial isostatic adjustment (GIA) correction error of 10-20 % is applied; however, the performance of the DDK5-filtered solution strongly depends

  10. Product DSS Model Based on Cloud Service%基于云服务的产品决策支持系统模型研究

    Institute of Scientific and Technical Information of China (English)

    冯青; 余隋怀; 杨延璞; 宋红; 陆长德

    2013-01-01

    为了更好地解决复杂产品设计中的决策服务问题,提出一种将云服务、需求驱动和面向服务架构(service oriented architecture,SOA)相结合的决策支持系统.在该决策支持系统中,通过云服务将各类软硬件设计资源和制造能力虚拟化和服务化,利用其富含语义的Web服务,实现决策支持过程中抽象决策过程建模与实际决策服务执行之间的动态映射.另外,为了提高系统的决策能力,在系统层次模型的基础上,提出了决策任务提交及分解模型,论述了模型各模块相互调用协作的运作流程,设计并开发了面向决策支持系统的云服务平台雏形,验证了该方法的可行性.%To solve the decision service problems in the process of complex product design,cloud services,requirements-driven and service-oriented architecture were used to DSS.In the DSS,through cloud service's virtualization and service-orientation to various types of hardware and software,also with its rich semantic web services,the decision support process modeling and dynamic mapping among the actual implementation of decision-making process service could be achieved.In addition,to improve the system's decision-making capacity,based on the system-level model the paper proposed the idea of decision-making task submission and a decomposition model;meanwhile,it discussed the module operation between each model and then developed cloud services platform prototype for DSS to verify the feasibility of this method.

  11. 基于多Agent的体育训练管理DSS的设计%Design on the physical training and management DSS based on Multi-Agent

    Institute of Scientific and Technical Information of China (English)

    周兴斌; 梅成

    2009-01-01

    根据目前高校体育训练管理中的问题,创建了一个基于Multi-Agent的体育训练管理决策支持系统.它是将Multi-A-gent技术应用到决策支持系统当中,从而有效地提高了系统的准确性和智能性.本文讨论了DSS,Agent和MAS的特点,并通过分析体育管理决策支持系统的功能需求,详细论述了基于Multi-Agent的体育训练管理决策支持系统的总体结构设计、A-gent的具体实现.

  12. GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.

    Science.gov (United States)

    Zhao, Yue; Sun, Yang; Ding, Youxiang; Wang, Xiaoping; Zhou, Yuxin; Li, Wenjun; Huang, Shaoliang; Li, Zhiyu; Kong, Lingyi; Guo, Qinglong; Lu, Na

    2015-09-22

    GL-V9, a new synthesized flavonoid derivative, has been reported to possess anti-cancer properties in our previous studies. Uncontrolled overproduction of reactive oxygen species (ROS) has been implicated in oxidative damage of inflammatory bowel disease (IBD). In this study, we aimed to investigate the protective effect of GL-V9 against dextran sulfate sodium (DSS)-induced colitis. GL-V9 attenuated DSS-induced body weight loss, colon length shortening and colonic pathological damage. GL-V9 also inhibited inflammatory cells infiltration and decreased myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities. Moreover, GL-V9 inhibited ROS and malondialdehyde (MDA) generation, but enhanced superoxide dismutase (SOD), glutathione (GSH) and total antioxidant capacity. GL-V9 reduced pro-inflammatory cytokines production in serum and colon as well. Mechanically, GL-V9 could increase Trx-1 via activation of AMPK/FOXO3a to suppress DSS-induced colonic oxidative stress. Furthermore, GL-V9 decreased pro-inflammatory cytokines and ROS production and increased the antioxidant defenses in the mouse macrophage cells RAW264.7 by promoting Trx-1 expression. In conclusion, our study demonstrated that GL-V9 attenuated DSS-induced colitis against oxidative stress by up-regulating Trx-1 via activation of AMPK/FOXO3a pathway, suggesting that GL-V9 might be a potential effective drug for colitis.

  13. The bending of the proton plus helium flux in primary cosmic rays measured by the ARGO-YBJ experiment in the energy range from 20 TeV to 5 PeV

    CERN Document Server

    Montini, P

    2016-01-01

    The measurement of proton plus helium and all-particle energy spectra in the range $20\\,$ TeV to $5 \\,$PeV and $80 \\,$TeV to $5 \\,$PeV respectively are presented. Data taken by the ARGO-YBJ detector in the 2010 year have been analyzed. The ARGO-YBJ experiment (Tibet, P. R. China) has been taking data for more than five years by means of a full-coverage array of RPC detectors. The discrimination between showers produced by light and heavy primaries has been performed by looking at the lateral particle density close to the core region. A Bayesian unfolding technique was therefore applied to the measured quantities in order to evaluate the cosmic ray energy spectrum. The proton plus helium spectrum clearly shows a bending at about $1 \\,$PeV, while the all-particle spectrum is consistent with previous observations.

  14. 葡聚糖硫酸钠(DSS)诱导的小鼠肠炎模型中CD19+CD5+CD1dhiB细胞的表达及抑炎作用%The role of CD19+CD5+CD1dhi B cells in dextran sulfact sodium (DSS)induced inflammatory bowel disease C57BL/6 mouse model

    Institute of Scientific and Technical Information of China (English)

    汪路曼; 钱静; 刘小明; 常丽君; 储以微

    2013-01-01

    目的 探讨CD19+ CD5+ CD1dhiB细胞在葡聚糖硫酸钠(dextran sulfact sodium,DSS)诱导的C57BL/6小鼠肠炎模型中的表达及抑炎作用.方法 建立DSS诱导的小鼠肠炎模型(n=200),获取疾病不同阶段的脾淋巴细胞,流式细胞仪检测CD19+ CD5+ CD1 dhiB细胞的比例变化;体内转输该群细胞至疾病小鼠,观察小鼠肠炎临床评分以及肠道局部炎性因子分泌的变化.结果 在小鼠肠炎的急性期(第0~10天),CD19+ CD5+CD1 dhiB细胞比例明显增多,在肠炎消退期(第12天),其比例恢复到正常水平;转输疾病急性期(第8天)的CD19+ CD5+ CD1 dhiB细胞可有效控制疾病的进展,缓解病程;ELISA检测提示转输急性期的该群细胞可显著抑制肠道局部促炎细胞因子IFN-γ、TNF-α和IL-6的分泌.结论 DSS诱导的小鼠肠炎中CD19+ CD5+ CD1 dhiB细胞比例随病程发生改变,并可通过抑制肠道局部炎性细胞因子的分泌缓解病症.%Objective To investigate the change in cell number of CD19 + CD5+ Cdldhi B cells and its function in dextran sulfate sodium (DSS) induced inflammatory bowel disease (IBD) C57BL/6 mouse model. Methods The murine model of inflammatory bowel disease was set up by DSS treatment. Splenic CD19+ CD5+ Cdldhi B cells were harvested from mice during different disease stages,and were analyzed by flow cytometry. CD19+ CD5+ Cdldhi B cells were adoptively transferred to the DSS-treated mice, then clinical symptom was evaluated and the production of inflammatory cytokines in local intestine was detected. Results The proportion of CD19+ CD5+ Cdldhi B cells was increased in the acute phase (Day 0 - 10) of the disease and returned to baseline in the recovery phase (Day 12). Adoptive transfer of CD19+ CD5+ Cdldhi B cells from mice in acute phase (Day 8) remarkably inhibited the production of proinflammatory cytokines (IFN-γ, TNF-α and IL-6) in local intestine and resolved the inflammation. Conclusions The proportion of CD19+ CD5+ Cdldhi B

  15. Online feature selection with streaming features.

    Science.gov (United States)

    Wu, Xindong; Yu, Kui; Ding, Wei; Wang, Hao; Zhu, Xingquan

    2013-05-01

    We propose a new online feature selection framework for applications with streaming features where the knowledge of the full feature space is unknown in advance. We define streaming features as features that flow in one by one over time whereas the number of training examples remains fixed. This is in contrast with traditional online learning methods that only deal with sequentially added observations, with little attention being paid to streaming features. The critical challenges for Online Streaming Feature Selection (OSFS) include 1) the continuous growth of feature volumes over time, 2) a large feature space, possibly of unknown or infinite size, and 3) the unavailability of the entire feature set before learning starts. In the paper, we present a novel Online Streaming Feature Selection method to select strongly relevant and nonredundant features on the fly. An efficient Fast-OSFS algorithm is proposed to improve feature selection performance. The proposed algorithms are evaluated extensively on high-dimensional datasets and also with a real-world case study on impact crater detection. Experimental results demonstrate that the algorithms achieve better compactness and higher prediction accuracy than existing streaming feature selection algorithms.

  16. Therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms%Allicin对DSS诱导的小鼠结肠炎的治疗作用及可能机制

    Institute of Scientific and Technical Information of China (English)

    陈晶; 李巧霞; 李玮; 李宏; 汤菲; 王缚鲲

    2016-01-01

    Objective:To analyze the therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms. Methods:A total of 24 male mice were randomly divided into Control group,DSS group(2. 5% DSS,7 days) and Allicin group [DSS treatment and Allicin,10 mg/(kg·d),7 d]. Disease activity index,inflammatory score,TUNEL and Western bolt were performed to analyze the effect of Allicin on colitis induced by DSS. Results: With DSS group, the Allicin group had lower disease activity score and inflammatory score(P<0. 05). Allicin group had a lower number of intestinal epithelial cell apoptosis than that of DSS group,the difference was statistically significant(P<0. 05). Western bolt analysis shown that Allicin treatment significantly depressed the expression of p-JAK2 and p-STAT3 in intestinal mucosa when compared with these of DSS group ( P<0. 05 ) . Conclusion:Conclusion Allicin has significantly therapeutic effect on mice colitis induced by DSS, the possible mechanisms including anti-inflammatory effects,protected of the intestinal epithelial cells and inhibition of the JAK2/STAT3 signaling pathways.%目的::明确Allicin对DSS诱导的小鼠结肠炎的治疗作用并进一步分析可能的机制。方法:将24只8周龄雄性BALB/c小鼠随机分为3组:Control组:阴性对照;DSS组:2.5%DSS诱导结肠炎;Allicin组:2.5%DSS诱导结肠炎+Allicin治疗[10 mg/(kg·d),共7 d]。结果:与DSS组比较,Allicin组疾病活动度评分及肠道炎症评分显著降低(P<0.05)。 Allicin治疗组小鼠肠上皮细胞凋亡数目显著低于DSS组。 Allicin治疗组小鼠肠黏膜炎症因子( IL-6、IL-1β及TNF-α)水平显著低于DSS组,差异均具有统计学意义( P<0.05)。与DSS组比较, Allicin治疗显著抑制了肠黏膜p-JAK2及p-STAT3的表达( P<0.05)。结论:Allicin对DSS小鼠肠炎具有治疗作用,可能的机制包括抗炎,保护肠上皮细胞及抑制JAK2/STAT3信号通路等。

  17. Action of arginine for protection of ulcerative colitis by dextran sodium sulphate (DSS); Acao da arginina na protecao da colite ulcerativa induzida por sulfato de sodio dextrano

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Maria Emilia Rabelo

    2016-10-01

    Recent studies have demonstrated the benefits of immunomodulators, such as arginine, in the regulation of inflammatory responses and trophism of the intestinal mucosa. The aim of this study was to evaluate the possible mechanisms action of arginine (pretreatment or treatment) in experimental model of ulcerative colitis induced by dextran sodium sulfate (DSS). C57BL/6 mice were randomized into 5 groups: Control group (C): standard diet and water; Arginine group (ARG): diet supplementation with arginine and water; Colitis group (COL): standard diet and DSS solution; Pretreated group (PT): diet supplementation with arginine before and during colitis induction; Treated group (T): diet supplementation with arginine during colitis induction. Colitis was induced by administration of 1.5% DSS for 5 days. After this, all the mice were euthanized and blood, organs and intestinal fluid were collected for carrying out analyzes. Parameters such as intestinal permeability (IP), bacterial translocation (BT), histological analysis (histological score, morphometric analysis, collagen and mucins stain), nitrate and nitrite, cytokines and chemokines, secretory immunoglobulin A (sIgA), inflammatory infiltrate and oxidative stress were performed. The ARG group did not show difference compared to group C in the investigated parameters (C vs ARG: p> 0.05). The COL group showed increased IP (C vs COL: p < 0.05) and BT (C vs COL: p <0.05). In the histological analysis, the COL group showed severe inflammation and reduction the crypts length. In addition, in the group COL observed increase infiltration of eosinophils, neutrophils and macrophages in the colon, increase cytokine IL-17 and chemokine KC in serum and oxidative stress in the colon (COL vs C: p <0.05). In the arginine-supplemented groups (PT and T) was observed decrease IP and BT to blood, liver and lung (PT and T vs Col: p <0.05). Histological analysis showed that the arginine (PT and T) preserved the intestinal mucosa and crypts

  18. R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.

    Science.gov (United States)

    Kang, Eugene; Yousefi, Mitra; Gruenheid, Samantha

    2016-01-01

    The R-spondin family of proteins has recently been described as secreted enhancers of β-catenin activation through the canonical Wnt signaling pathway. We previously reported that Rspo2 is a major determinant of susceptibility to Citrobacter rodentium-mediated colitis in mice and recent genome-wide association studies have revealed RSPO3 as a candidate Crohn's disease-specific inflammatory bowel disease susceptibility gene in humans. However, there is little information on the endogenous expression and cellular source of R-spondins in the colon at steady state and during intestinal inflammation. RNA sequencing and qRT-PCR were used to assess the expression of R-spondins at steady state and in two mouse models of colonic inflammation. The cellular source of R-spondins was assessed in specific colonic cell populations isolated by cell sorting. Data mining from publicly available datasets was used to assess the expression of R-spondins in the human colon. At steady state, colonic expression of R-spondins was found to be exclusive to non-epithelial CD45- lamina propria cells, and Rspo3/RSPO3 was the most highly expressed R-spondin in both mouse and human colon. R-spondin expression was found to be highly dynamic and differentially regulated during C. rodentium infection and dextran sodium sulfate (DSS) colitis, with notably high levels of Rspo3 expression during DSS colitis, and high levels of Rspo2 expression during C. rodentium infection, specifically in susceptible mice. Our data are consistent with the hypothesis that in the colon, R-spondins are expressed by subepithelial stromal cells, and that Rspo3/RSPO3 is the family member most implicated in colonic homeostasis. The differential regulation of the R-spondins in different models of intestinal inflammation indicate they respond to specific pathogenic and inflammatory signals that differ in the two models and provides further evidence that this family of proteins plays a key role in linking intestinal

  19. Bifidobacterium infantis strains with and without a combination of Oligofructose and Inulin (OFI attenuate inflammation in DSS-induced colitis in rats

    Directory of Open Access Journals (Sweden)

    Ahrne Siv

    2006-10-01

    Full Text Available Abstract Background Pathogenesis of inflammatory bowel disease is thought to be through different factors and there is a relationship between the gut flora and the risk of its development. Probiotics can manipulate the microflora in chronic inflammation and may be effective in treating inflammation. Bifidobacterium are saccharolytic and their growth in the gut can be promoted by non-absorbable carbohydrates and its increase in the colon appears to be of benefit. Methods Oligofructose and inulin (OFI alone and the two B. infantis DSM 15158 and DSM 15159 with and without OFI, were fed to Sprague-Dawley rats for 7 days prior to colitis induction and administrations continued for another 7 days with the DSS. Colitis severity assessed using a Disease Activity Index. Samples were collected 7 days after colitis induction, for intestinal bacterial flora, bacterial translocation, short chain fatty acids (SCFAs, myeloperoxidase (MPO, cytokines (IL-1β, TNF-α, IL-10 and TGF-β and malondialdehyde (MDA. Results OFI alone or the B. infantis strains with and without OFI improved significantly the DAI and decreased colonic MPO activity. Colonic tissue IL-1β decreased significantly in all treated groups except B. infantis DSM 15158. MDA decreased significantly in B. infantis DSM 15159 with and without OFI compared to colitis control. Succinic acid increased significantly in OFI group with and without DSM 15159 compared to all groups. Sum values of propionic, succinic acid and butyric acid increased significantly in all groups compare to the colitis control. Bacterial translocation to mesenteric lymph nodes decreased significantly in all groups compared to colitis control. Translocation to the liver decreased significantly in all groups compare to the colitis control and OFI + B. infantis DSM 15158 groups. Conclusion Administrations of OFI and Bifidobacterium improve DSS-induced acute colitis and have an anti-inflammatory effect. Major differences in effect

  20. Study on welded structure fatigue of DSS used in shipbuilding%船用双相不锈钢焊接结构疲劳性能研究

    Institute of Scientific and Technical Information of China (English)

    王智祥; 王正伦; 张鑫

    2012-01-01

    文章对船用双相不锈钢焊接结构的焊缝、影响区和母材在不同应力比下分别进行了疲劳裂纹扩展实验,同时利用有限元分析软件进行了数值模拟,得到了裂纹扩展速率da/dN与应力强度因子(△ )K的关系曲线.研究结果表明:船用双相不锈钢焊接结构中焊缝裂纹扩展速率最低,抗疲劳裂纹扩展能力最高;母材疲劳裂纹扩展速率最高,抗疲劳裂纹扩展能力最差;焊缝对应力变化的灵敏度最高,热影响区次之,母材最弱;通过实验与模拟对比分析,表明数值模拟对船用双相不锈钢疲劳裂纹扩展速率定量分析是正确的且方法可行.%The fatigue crack growth grate in weld metal, heat-affected zone and base metal of Duplex Stain-less Steel (DSS) used in shipbuilding was tested at different stress ratios. FEM analysis software was used to simulate the steel under different stress ratio at the same time, and the AaldN-AK curves of this steel were obtained. The research results show that the fatigue crack growth rate of weld metal is the slowest and the ability to resist fatigue crack growth is the highest in the three parts, the lowest is base metal. Secondly, the sensitivity caused by the stress change of weld metal is the highest, and the lowest is base metal. The com-parison between finite element simulation and experiment shows that the simulation of fatigue crack growth rate of DSS used in shipbuilding is completely correct and feasible.

  1. The cosmic ray proton plus helium energy spectrum measured by the ARGO-YBJ experiment in the energy range 3-300 TeV

    CERN Document Server

    :,; Bernardini, P; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini, P; Santonico, R; Settanta, G; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q

    2015-01-01

    The ARGO-YBJ experiment is a full-coverage air shower detector located at the Yangbajing Cosmic Ray Observatory (Tibet, People's Republic of China, 4300 m a.s.l.). The high altitude, combined with the full-coverage technique, allows the detection of extensive air showers in a wide energy range and offer the possibility of measuring the cosmic ray proton plus helium spectrum down to the TeV region, where direct balloon/space-borne measurements are available. The detector has been in stable data taking in its full configuration from November 2007 to February 2013. In this paper the measurement of the cosmic ray proton plus helium energy spectrum is presented in the region 3-300 TeV by analyzing the full collected data sample. The resulting spectral index is $\\gamma = -2.64 \\pm 0.01$. These results demonstrate the possibility of performing an accurate measurement of the spectrum of light elements with a ground based air shower detector.

  2. Detection of thermal neutrons with the PRISMA-YBJ array in Extensive Air Showers selected by the ARGO-YBJ experiment

    CERN Document Server

    Bartoli, B; Bi, X J; Cao, Z; Catalanotti, S; Chen, S Z; Chen, T L; Cui, S W; Dai, B Z; D'Amone, A; Danzengluobu,; De Mitri, I; Piazzoli, B D'Ettorre; Di Girolamo, T; Di Sciascio, G; Feng, C F; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q B; Guo, Y Q; He, H H; Hu, Haibing; Hu, Hongbo; Iacovacci, M; Iuppa, R; Jia, H Y; Labaciren,; Li, H J; Liu, C; Liu, J; Liu, M Y; Lu, H; Ma, L L; Ma, X H; Mancarella, G; Mari, S M; Marsella, G; Mastroianni, S; Montini, P; Ning, C C; Perrone, L; Pistilli, P; Salvini, P; Santonico, R; Shen, P R; Sheng, X D; Shi, F; Surdo, A; Tan, Y H; Vallania, P; Vernetto, S; Vigorito, C; Wang, H; Wu, C Y; Wu, H R; Xue, L; Yang, Q Y; Yang, X C; Yao, Z G; Yuan, A F; Zha, M; Zhang, H M; Zhang, L; Zhang, X Y; Zhang, Y; Zhao, J; Zhaxiciren,; Zhaxisangzhu,; Zhou, X X; Zhu, F R; Zhu, Q Q; Stenkin, Yu V; Alekseenko, V V; Aynutdinov, V; Cai, Z Y; Guo, X W; Liu, Y; Rulev, V; Shchegolev, O B; Stepanov, V; Volchenko, V; Zhang, H

    2015-01-01

    We report on a measurement of thermal neutrons, generated by the hadronic component of extensive air showers (EAS), by means of a small array of EN-detectors developed for the PRISMA project (PRImary Spectrum Measurement Array), novel devices based on a compound alloy of ZnS(Ag) and 6LiF. This array has been operated within the ARGO-YBJ experiment at the high altitude Cosmic Ray Observatory in Yangbajing (Tibet, 4300 m a.s.l.). Due to the tight correlation between the air shower hadrons and thermal neutrons, this technique can be envisaged as a simple way to get information on the EAS hadronic component, avoiding the use of huge calorimeters. Coincident events generated by primary cosmic rays of energies greater than 100 TeV have been selected and analyzed. The EN-detectors have been used to record simultaneously thermal neutrons and the air shower electromagnetic component. The density distribution of both components and the total number of thermal neutrons have been measured. The correlation of these data w...

  3. Migration and diving behavior of Centrophorus squamosus in the NE Atlantic. Combining electronic tagging and Argo hydrography to infer deep ocean trajectories

    Science.gov (United States)

    Rodríguez-Cabello, Cristina; González-Pola, Cesar; Sánchez, Francisco

    2016-09-01

    A total of nine leafscale gulper sharks Centrophorus squamosus (Bonnaterre, 1788), were tagged with pop-up, satellite, archival, transmitting tags (PSAT) in the Marine Protected Area (MPA) of El Cachucho (Le Danois Bank) located in waters to the north of Spain, (NE Atlantic). Tags provided data on time, pressure and temperature that were used to examine movement patterns and diving behavior. Data collected from Argo floats in the study area have been used to devise a simple geolocation algorithm to infer the probable routes followed by this species. Tag release points revealed that C. squamosus moved both to the west (Galician waters) and to the north (Porcupine Bank) from the tagging area, suggesting well defined preferred pathways. The inferred trajectories indicated that sharks alternate periods constrained to specific geographical regions with quick and prompt movements covering large distances. Two sharks made conspicuous diurnal vertical migrations being at shallower depths around midnight and at maximum depths at midday, while other sharks did not make vertical migrations. Vertical movements were done smoothly and independently of the fish swimming long-distances or resting in the area. Overall results confirm that this species is highly migratory, supporting speeds of 20 nautical miles.day-1 and well capable to swim and make vertical migrations well above the abyssal plain.

  4. Study on the Sensitivity in Detecting Crab Nebula by ARGO-YBJ Experiment%羊八井ARGO实验对Crab源灵敏度的研究

    Institute of Scientific and Technical Information of China (English)

    崔树旺; 胡红波; 王焕玉; 卢红; 谭有恒

    2005-01-01

    应用Monte-Carlo研究给出羊八井ARGO(Astrophysical Radiation with Ground-based Observatory)实验的角分辨能力.采用Whipple实验给出的蟹状星云(Crab Nebula)TeV能区的微分流强参量,对3种统计显著性的方法进行了比较,研究表明:以信号和本底的似然比为权重的加权方法能够给出最优化的结果.在没有考虑γ/P鉴别能力的条件下,ARGO实验运行一年能够观测到来自Crab源累计超出平均可达18σ显著水平,以5σ为标准,实验可达到小于0.3Icrab的灵敏度.

  5. Measurement of the cosmic ray antiproton/proton flux ratio at TeV energies with the ARGO-YBJ detector

    CERN Document Server

    ,

    2012-01-01

    Cosmic ray antiprotons provide an important probe to study the cosmic ray propagation in the interstellar space and to investigate the existence of dark matter. Acting the Earth-Moon system as a magnetic spectrometer, paths of primary antiprotons are deflected in the opposite sense with respect to those of the protons in their way to the Earth. This effect allows, in principle, the search for antiparticles in the direction opposite to the observed deficit of cosmic rays due to the Moon (the so-called `Moon shadow'). The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$), is particularly effective in measuring the cosmic ray antimatter content via the observation of the cosmic rays shadowing effect due to: (1) good angular resolution, pointing accuracy and long-term stability; (2) low energy threshold; (3) real sensitivity to the geomagnetic field. Based on all the data recorded during the period from July 2006 through November 2009 and on a fu...

  6. Pregnancy specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice

    Science.gov (United States)

    Blois, Sandra M.; Sulkowski, Gisela; Tirado-González, Irene; Warren, James; Freitag, Nancy; Klapp, Burghard F.; Rifkin, Daniel; Fuss, Ivan; Strober, Warren; Dveksler, Gabriela S.

    2013-01-01

    Transforming growth factor beta (TGF-βs) are secreted from cells as latent complexes and the activity of TGF-βs is controlled predominantly through activation of these complexes. Tolerance to the fetal allograft is essential for pregnancy success; TGF-β1 and -β2 play important roles in regulating these processes. Pregnancy-specific β-glycoproteins (PSGs) are present in the maternal circulation at high concentration throughout pregnancy and have been proposed to have anti-inflammatory functions. We found that recombinant and native PSG1 activate TGF-β1 and TGF-β2 in vitro. Consistent with these findings, administration of PSG1 protected mice from DSS-induced colitis, reduced the secretion of pro-inflammatory cytokines and increased the number of T regulatory cells. The PSG1-mediated protection was greatly inhibited by the co-administration of neutralizing anti-TGF-β Ab. Our results indicate that proteins secreted by the placenta directly contribute to the generation of active TGF-β and identify PSG1 as one of the few known biological activators of TGF-β2. PMID:23945545

  7. Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis

    Science.gov (United States)

    Coutinho de Sousa, Beatriz; da Costa, Thiago Alvares; Lazo-Chica, Javier Emilio; Degasperi, Thatiane do Prado; Rodrigues Junior, Virmondes; Uber Bucek, Elizabeth

    2017-01-01

    Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease. PMID:28194046

  8. A study of biodiversity using DSS method and seed storage protein comparison of populations in two species of Achillea L. in the west of Iran

    Directory of Open Access Journals (Sweden)

    Hajar Salehi

    2013-11-01

    Full Text Available Intarspecific and interspecific variations are the main reserves of biodiversity and both are important sources of speciation. On this basis, identifing and recognizing the intra and interspecific variations is important in order to recognition of biodiversity. This research was done to study biodiversity and electrophoresis comparison of seed storage proteins in the populations of the two species of the genus Achillea in Hamadan and Kurdistan provinces using of the method of determination of special station (DSS. For this purpose, 12 and 9 special stations were selected for the species A. tenuifolia and A. biebresteinii using the data published in the related flora. Seed storage proteins were extracted and then studied using electrophoresis techniques (SDS-PAGE. In survey of all special stations, 120 plant species were distinguished as associated species. The results of the floristic data for the both species determined six distinctive groups that indicated the existence of intraspecific diversity in this species. The result of analysis of ecological data and seed storage proteins for the two species was in accordance with the floristic data and showed six distinctive groups. The existence of the bands of no. 4, 5, 8, 12 and 13 in the special stations of A. tenuifolia and the bands of 14, 15 and 16 in the special stations of A. biebresteinii o separated the populations of the species in two quite different and distinctive groups.

  9. Morinda citrifolia (Noni Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis

    Directory of Open Access Journals (Sweden)

    Beatriz Coutinho de Sousa

    2017-01-01

    Full Text Available Morinda citrifolia L. (noni has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.

  10. Designing of a Decision Support System (DSS for resource allocation with genetic algorithm approach (Case Study: Central Library of Tarbiat Modares University

    Directory of Open Access Journals (Sweden)

    Alireza Hasanzadeh

    2014-09-01

    Full Text Available The allocation of information is one of the main responsibilities of a manager. In case there is a limitation in the available resources, the issue of resources allocation is raised. Universities and post graduate centers have faced limitations in accessing resources such as budget, human resources, physical space, etc. This problem results in inappropriate use of the approved budget in buying and sharing the different types of information resources, lack of easy access to information resources by users, and users’ dissatisfaction. This paper is intended to see whether the model of genetic algorithm can be used in helping library heads of university to develop a support system for the proper allocation of resources. The data of the central library of a university as the main core of DSS through using genetic algorithm in MATLAB was used in order to come up with a better distribution of effective resources. Research methodology used in this paper was field study and survey. The findings indicated that genetic algorithm was successful in achieving this end.

  11. Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification

    Science.gov (United States)

    Jin, Shuang; Zhao, Di; Cai, Chenwen; Song, Dongjuan; Shen, Jun; Xu, Antao; Qiao, Yuqi; Ran, Zhihua; Zheng, Qing

    2017-01-01

    Antibiotic exposure in early life can lead to a significant change of the gut microbiota and may contribute to later onset of inflammatory bowel disease (IBD). However, the relationship between early-life antibiotic treatment and IBD is ambiguous, according to contradicting results of epidemiologic studies. In the present study, we demonstrated that low-dose penicillin pre-treatment had a unique protective effect against mouse colitis induced by dextran sodium sulfate (DSS). Low-dose penicillin also suppressed the expression of pro-inflammatory cytokine IL-17 in various intestinal tissues, and decreased the amount of Th17 cells in small-intestine lamina propria. Neither metronidazole nor enrofloxacin had a similar effect. We further confirmed that low-dose penicillin could cause specific changes of the gut microbiota, especially the eradication of segmented filamentous bacteria (SFB). Mice without SFB inoculation showed no disparity when treated with penicillin or water. Taken together, the results showed that low-dose penicillin can achieve a highly specific manipulation of sensitive bacteria and interfere with development of intestinal immune system in early life. The study may further indicate the possibility of achieving a favorable immune state among a certain group of patients with IBD, or other autoimmune diseases, by fine-tuning the gut microbiota. PMID:28272549

  12. Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-κB Pathway

    Science.gov (United States)

    Breyner, Natalia M.; Michon, Cristophe; de Sousa, Cassiana S.; Vilas Boas, Priscilla B.; Chain, Florian; Azevedo, Vasco A.; Langella, Philippe; Chatel, Jean M.

    2017-01-01

    Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. In this current proof we tested MAM effect on NF-κB pathway in vivo, using a transgenic model of mice producing luciferase under the control of NF-κB promoter. Moreover, we tested this protein on Dextran Sodium Sulfate (DSS)-induced colitis in mice. To study the effect of MAM we orally administered to the mice a Lactococcus lactis strain carrying a plasmid containing the cDNA of MAM under the control of a eukaryotic promoter. L. lactis delivered plasmids in epithelial cells of the intestinal membrane allowing thus the production of MAM directly by host. We showed that MAM administration inhibits NF-κB pathway in vivo. We confirmed the anti-inflammatory properties of MAM in DNBS-induced colitis but also in DSS model. In DSS model MAM was able to inhibit Th1 and Th17 immune response while in DNBS model MAM reduced Th1, Th2, and Th17 immune response and increased TGFβ production. PMID:28203226

  13. 基于黑板的多Agent体育训练管理DSS系统设计%Design of multi-Agent sports training management DSS based on blackboard

    Institute of Scientific and Technical Information of China (English)

    张维

    2014-01-01

    The shortcomings that sports training management is not science,the training purpose is not clear,and the auxi-liary decision means lags behind,still exist in China at present. A scheme to realize the multi-Agent intelligent DSS based on blackboard for sports training management was designed,in which Agent and DSS technology are applied. The system was imple-mented,so as to effectively improve the accuracy and intelligence of DSS.%目前我国的体育训练管理中仍然存在着不科学、训练目的性不强、辅助决策手段落后等缺点。将Agent和DSS技术运用到系统当中,设计出一个基于黑板的多Agent智能体育训练管理决策支持系统方案,并进行具体的实施,从而有效地提高了决策系统的准确性和智能性。

  14. Clinical and virological features of Dengue in Vietnamese infants.

    Directory of Open Access Journals (Sweden)

    Tran Nguyen Bich Chau

    Full Text Available BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness. CONCLUSIONS/SIGNIFICANCE: Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.

  15. Designing using manufacturing features

    Science.gov (United States)

    Szecsi, T.; Hoque, A. S. M.

    2012-04-01

    This paper presents a design system that enables the composition of a part using manufacturing features. Features are selected from feature libraries. Upon insertion, the system ensures that the feature does not contradict the design-for-manufacture rules. This helps eliminating costly manufacturing problems. The system is developed as an extension to a commercial CAD/CAM system Pro/Engineer.

  16. Features of the Bible

    Institute of Scientific and Technical Information of China (English)

    刘隽

    2008-01-01

    Every literature has its features in some aspects,so is the Bible,one of the greatest literary works in the world that has great impact on western literature.This paper summarizes two features of the Bible,namely,cultural feature and literary feature.

  17. Feature-Aware Verification

    CERN Document Server

    Apel, Sven; Wendler, Philipp; von Rhein, Alexander; Beyer, Dirk

    2011-01-01

    A software product line is a set of software products that are distinguished in terms of features (i.e., end-user--visible units of behavior). Feature interactions ---situations in which the combination of features leads to emergent and possibly critical behavior--- are a major source of failures in software product lines. We explore how feature-aware verification can improve the automatic detection of feature interactions in software product lines. Feature-aware verification uses product-line verification techniques and supports the specification of feature properties along with the features in separate and composable units. It integrates the technique of variability encoding to verify a product line without generating and checking a possibly exponential number of feature combinations. We developed the tool suite SPLverifier for feature-aware verification, which is based on standard model-checking technology. We applied it to an e-mail system that incorporates domain knowledge of AT&T. We found that feat...

  18. Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis.

    Science.gov (United States)

    Camuesco, Desirée; Gálvez, Julio; Nieto, Ana; Comalada, Mònica; Rodríguez-Cabezas, M Elena; Concha, Angel; Xaus, Jordi; Zarzuelo, Antonio

    2005-04-01

    Previous studies proposed a protective role of the dietary intake of (n-3) PUFA in human inflammatory bowel disease (IBD), but almost no studies have been performed using olive oil. The aims of the present study were to test the beneficial effects of an olive oil-based diet with or without fish oil, rich in (n-3) PUFA, in the dextran sodium sulfate (DSS) model of rat colitis and to elucidate the mechanisms involved in their potential beneficial effects, with special attention to the production of some of the mediators involved in the intestinal inflammatory response, such as leukotriene B(4) (LTB(4)), tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO). Rats were fed the different diets for 2 wk before colitis induction and thereafter until colonic evaluation 15 d later. Colitic rats fed the olive oil-based diet had a lower colonic inflammatory response than those fed the soybean oil diet, and this beneficial effect was increased by the dietary incorporation of (n-3) PUFA. A restoration of colonic glutathione levels and lower colonic NO synthase expression occurred in all colitic rats fed an olive oil diet compared with the control colitic group that consumed the soybean oil diet. However, (n-3) PUFA incorporation into an olive oil diet significantly decreased colonic TNFalpha and LTB(4) levels compared with colitic rats that were not supplemented with fish oil. These results affirm the benefits of an olive oil diet in the management of IBD, which are further enhanced by the addition of (n-3) PUFA.

  19. VizieR Online Data Catalog: 4.5yr obs. of Mrk421 with ARGO-YBJ & Fermi (Bartoli+, 2016)

    Science.gov (United States)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; de Mitri, I.; D'Ettorre Piazzoli, B.; di Girolamo, T.; di Sciascio, G.; Feng, C. F.; Feng, Z.; Feng, Z.; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, H.; Hu, H.; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.

    2016-02-01

    In this paper, we report on the 4.5 year multi-wavelength data recorded from 2008 August to 2013 February, a period that includes several large flares of Mrk 421. The Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) is an extensive air showers (EAS) detector located at the Yangbajing Cosmic Ray Laboratory in Tibet, P.R. China (0.3-10TeV). Fermi-LAT (energy range above 100MeV) began taking science data in 2008 August. The data used in this work have been downloaded through the Fermi science support center. To obtain the Swift/BAT (14-195keV) SED, we downloaded all the available data of Mrk 421 through the HEASARC data archive. The MAXI Gas Slit Camera (GSC) detector, operating in the 2-20keV range, began taking data in 2009 August. The light curves for specific sources are publicly available. The RXTE-ASM data in the 2-12keV range are publicly available. The Swift X-ray Telescope (XRT) is a focusing X-ray telescope with an energy range from 0.2 to 10keV. Swift-UVOT observations of Mrk 421, at the three ultraviolet bands (UVW1, UVM2, and UVW2) are also available at the HEASARC data archive. The OVRO is a 40m radio telescope working at 15.0GHz with 3GHz bandwidth. The light curve for Mrk 421 is publicly available. (2 data files).

  20. Comparison of 37 months global net radiation flux derived from PICARD-BOS over the same period observations of CERES and ARGO

    Science.gov (United States)

    Zhu, Ping; Wild, Martin

    2016-04-01

    The absolute level of the global net radiation flux (NRF) is fixed at the level of [0.5-1.0] Wm-2 based on the ocean heat content measurements [1]. The space derived global NRF is at the same order of magnitude than the ocean [2]. Considering the atmosphere has a negligible effects on the global NRF determination, the surface global NRF is consistent with the values determined from space [3]. Instead of studying the absolute level of the global NRF, we focus on the interannual variation of global net radiation flux, which were derived from the PICARD-BOS experiment and its comparison with values over the same period but obtained from the NASA-CERES system and inferred from the ocean heat content survey by ARGO network. [1] Allan, Richard P., Chunlei Liu, Norman G. Loeb, Matthew D. Palmer, Malcolm Roberts, Doug Smith, and Pier-Luigi Vidale (2014), Changes in global net radiative imbalance 1985-2012, Geophysical Research Letters, 41 (no.15), 5588-5597. [2] Loeb, Norman G., John M. Lyman, Gregory C. Johnson, Richard P. Allan, David R. Doelling, Takmeng Wong, Brian J. Soden, and Graeme L. Stephens (2012), Observed changes in top-of-the-atmosphere radiation and upper-ocean heating consistent within uncertainty, Nature Geoscience, 5 (no.2), 110-113. [3] Wild, Martin, Doris Folini, Maria Z. Hakuba, Christoph Schar, Sonia I. Seneviratne, Seiji Kato, David Rutan, Christof Ammann, Eric F. Wood, and Gert Konig-Langlo (2015), the energy balance over land and oceans: an assessment based on direct observations and CMIP5 climate models, Climate Dynamics, 44 (no.11-12), 3393-3429.

  1. IL-33 alleviates DSS-induced chronic colitis in C57BL/6 mice colon lamina propria by suppressing Th17 cell response as well as Th1 cell response.

    Science.gov (United States)

    Zhu, Junfeng; Wang, Yuanyuan; Yang, Fangli; Sang, Lixuan; Zhai, Jingbo; Li, Shengjun; Li, Yan; Wang, Danan; Lu, Changlong; Sun, Xun

    2015-12-01

    Interleukin (IL)-33, a member of the IL-1 cytokine family, is associated with autoimmune diseases including inflammatory bowel diseases (IBD). A few studies on animal models have shown that IL-33 can suppress Th1 cell response and improve Th2 cell response in mesenteric lymph nodes (MLN) and sera. However, there is little data published about the effect of IL-33 on Th17 cell in and Th1/Th2 cell in colon lamina propria. The aim of this study was to investigate the effect of IL-33 on Th17 cell in colon lamina propria of mice with dextran sulfate sodium (DSS) induced chronic colitis. We studied the influence of IL-33 on colonic tissue injury and clinical symptoms of colitis. The T cell subsets were measured by flow cytometry and the production of cytokines secreted by lamina propria lymphocytes (LPL) was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and quantitative real-time PCR. We have found that rIL-33 treatment led to a significant alleviation of DSS induced chronic colitis as evidenced by 1) alleviation of weight loss, DAI, macroscopic changes and histological score; 2) down-regulating the rates and absolute cell numbers of Th17 and Th1 cell in LPL; 3) inducing secretion of lower levels of IFN-γ and IL-17A. It is therefore concluded that IL-33 may play a therapeutic role in DSS-induced chronic colitis in mice by suppressing Th17 response and switching Th1 to Th2 response.

  2. DSS--A Promising Future.

    Science.gov (United States)

    Penrod, James I.; Wasileski, John S.

    1985-01-01

    A description of how the decision support systems at Pepperdine University are helping its office of institutional research and planning provide the support necessary to keep the university's administration well-informed in their decision-making role is presented. (MLW)

  3. Parallel Feature Extraction System

    Institute of Scientific and Technical Information of China (English)

    MAHuimin; WANGYan

    2003-01-01

    Very high speed image processing is needed in some application specially for weapon. In this paper, a high speed image feature extraction system with parallel structure was implemented by Complex programmable logic device (CPLD), and it can realize image feature extraction in several microseconds almost with no delay. This system design is presented by an application instance of flying plane, whose infrared image includes two kinds of feature: geometric shape feature in the binary image and temperature-feature in the gray image. Accordingly the feature extraction is taken on the two kind features. Edge and area are two most important features of the image. Angle often exists in the connection of the different parts of the target's image, which indicates that one area ends and the other area begins. The three key features can form the whole presentation of an image. So this parallel feature extraction system includes three processing modules: edge extraction, angle extraction and area extraction. The parallel structure is realized by a group of processors, every detector is followed by one route of processor, every route has the same circuit form, and works together at the same time controlled by a set of clock to realize feature extraction. The extraction system has simple structure, small volume, high speed, and better stability against noise. It can be used in the war field recognition system.

  4. Quasi-static time-series simulation using OpenDSS in IEEE distribution feeder model with high PV penetration and its impact on solar forecasting

    Science.gov (United States)

    Mohammed, Touseef Ahmed Faisal

    Since 2000, renewable electricity installations in the United States (excluding hydropower) have more than tripled. Renewable electricity has grown at a compounded annual average of nearly 14% per year from 2000-2010. Wind, Concentrated Solar Power (CSP) and solar Photo Voltaic (PV) are the fastest growing renewable energy sectors. In 2010 in the U.S., solar PV grew over 71% and CSP grew by 18% from the previous year. Globally renewable electricity installations have more than quadrupled from 2000-2010. Solar PV generation grew by a factor of more than 28 between 2000 and 2010. The amount of CSP and solar PV installations are increasing on the distribution grid. These PV installations transmit electrical current from the load centers to the generating stations. But the transmission and distribution grid have been designed for uni-directional flow of electrical energy from generating stations to load centers. This causes imbalances in voltage and switchgear of the electrical circuitry. With the continuous rise in PV installations, analysis of voltage profile and penetration levels remain an active area of research. Standard distributed photovoltaic (PV) generators represented in simulation studies do not reflect the exact location and variability properties such as distance between interconnection points to substations, voltage regulators, solar irradiance and other environmental factors. Quasi-Static simulations assist in peak load planning hour and day ahead as it gives a time sequence analysis to help in generation allocation. Simulation models can be daily, hourly or yearly depending on duty cycle and dynamics of the system. High penetration of PV into the power grid changes the voltage profile and power flow dynamically in the distribution circuits due to the inherent variability of PV. There are a number of modeling and simulations tools available for the study of such high penetration PV scenarios. This thesis will specifically utilize OpenDSS, a open source

  5. Improvement of radiological consequence estimation methodologies for NPP accidents in the ARGOS and RODOS decision support systems through consideration of contaminant physico-chemical forms

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K.G.; Roos, P. [Technical University of Denmark - DTU (Denmark); Lind, O.C.; Salbu, B. [Norwegian University of Life Sciences/CERAD - NMBU (Norway); Bujan, A.; Duranova, T. [VUJE, Inc. (Slovakia); Ikonomopoulos, A.; Andronopoulos, S. [National Centre for Scientific Research ' Demokritos' (Greece)

    2014-07-01

    The European standard computerized decision support systems RODOS and ARGOS, which are integrated in the operational nuclear emergency preparedness in practically all European countries, as well as in a range of non-European countries, are highly valuable tools for radiological consequence estimation, e.g., in connection with planning and exercising as well as in justification and optimization of intervention strategies. Differences between the Chernobyl and Fukushima accident atmospheric release source terms have demonstrated that differences in release conditions and processes may lead to very different degrees of volatilization of some radionuclides. Also the physico-chemical properties of radionuclides released can depend strongly on the release process. An example from the Chernobyl accident of the significance of this is that strontium particles released in the fire were oxidized and thus generally physico-chemically different from those released during the preceding explosion. This is reflected in the very different environmental mobility of the two groups of particles. The initial elemental matrix characteristics of the contaminants, as well as environmental parameters like pH, determine for instance the particle dissolution time functions, and thus the environmental mobility and potential for uptake in living organisms. As ICRP recommends optimization of intervention according to residual dose, it is crucial to estimate long term dose contributions adequately. In the EURATOM FP7 project PREPARE, an effort is made to integrate physico-chemical forms of contaminants in scenario-specific source term determination, thereby enabling consideration of influences on atmospheric dispersion/deposition, post-deposition migration, and effectiveness of countermeasure implementation. The first step in this context was to investigate, based on available experience, the important physico-chemical properties of radio-contaminants that might potentially be released to the

  6. Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.

    Science.gov (United States)

    Shon, Woo-Jeong; Lee, Young-Kwan; Shin, Ji Hee; Choi, Eun Young; Shin, Dong-Mi

    2015-11-27

    Indoleamine 2,3 -dioxygenase 1 (IDO1) catalyzes L-tryptophan to kynurenine in the first and rate-limiting step of tryptophan metabolism. IDO1 is expressed widely throughout the body, with especially high expression in colonic intestinal tissues. To examine the role of IDO1 in the colon, transcriptome analysis was performed in both Ido1(-/-) and Ido1(+/+) mice. Gene set enrichment analysis identified the Inflammatory Response as the most significant category modulated by the absence of IDO1. This observation prompted us to further investigate the function of IDO1 in the development of tissue inflammation. By using DSS-induced experimental colitis mice models, we found that the disease in Ido1(-/-) mice was less severe than in Ido1(+/+) mice. Pharmacological inhibition of IDO1 by L-1MT attenuated the severity of DSS-colitis as well. Transcriptome analyses revealed that pathways involving TLR and NF-kB signaling were significantly down-regulated by the absence of IDO1. Furthermore, dramatic changes in TLR and NF-kB signaling resulted in substantial changes in the expression of many inflammatory cytokines and chemokines. Numbers of inflammatory cells in colon and peripheral blood were reduced in IDO1 deficiency. These findings suggest that IDO1 plays important roles in producing inflammatory responses and modulating transcriptional networks during the development of colitis.

  7. DSS与TNBS诱导大鼠实验性结肠炎模型的对比研究%Experimental Colitis Model Induced by DSS and TNBS in Rats:A Comparative Study

    Institute of Scientific and Technical Information of China (English)

    赵平; 董蕾; 罗金燕; 管海涛; 宋亚华; 龚均

    2015-01-01

    Background:As the empirical studies on human body are restricted extremely,the establishment and selection of suitable animal models are important for researches on ulcerative colitis( UC ). Aims:To compare the symptoms and colonic pathology of rat models with experimental colitis induced by dextran sulfate sodium( DSS ) and trinitrobenzene sulfonic acid( TNBS),so as to provide a reference for selecting animal models in UC-related studies. Methods:Drinking 4% DSS freely for 7 days or intrarectal administration of single dose 100 mg/kg TNBS-50% ethanol were used to establish experimental colitis model in Sprague-Dawley rats. The disease activity index( DAI)was assessed dynamically during the course of experiment. The whole colon was removed in batches for measurements of colonic damage score and activity of myeloperoxidase(MPO)at different time points. Results:The DAI score reached the peak at the 7th day and the 2nd day in DSS group and TNBS group,respectively,and decreased gradually afterwards. Six and one deaths occurred during the experimental course in DSS and TNBS groups,respectively. In DSS group,the duration of inflammation was short,the colonic injury was moderate and recovered after drug withdrawal. At the 18th day,the colonic damage score and MPO activity was 0. 25 ± 0. 50 and(0. 80 ± 0. 33)U/g,respectively,and no significant differences were seen between DSS group and normal control group. In TNBS group,the duration of inflammation was longer and the colonic injury was more severe. At the 21st day,the colonic damage score and MPO activity was 3. 60 ± 0. 55 and( 1. 60 ± 0. 39 ) U/g, respectively,and chronic inflammation was observed histologically. Conclusions:Both DSS and TNBS can induce experimental colitis model in rats. The course of TNBS-induced colitis model presents a transformation of acute to chronic inflammation,and may be more suitable for treatment-related studies of UC.%背景:鉴于人体实验受到诸多限制,建立、选择合

  8. JCE Feature Columns

    Science.gov (United States)

    Holmes, Jon L.

    1999-05-01

    The Features area of JCE Online is now readily accessible through a single click from our home page. In the Features area each column is linked to its own home page. These column home pages also have links to them from the online Journal Table of Contents pages or from any article published as part of that feature column. Using these links you can easily find abstracts of additional articles that are related by topic. Of course, JCE Online+ subscribers are then just one click away from the entire article. Finding related articles is easy because each feature column "site" contains links to the online abstracts of all the articles that have appeared in the column. In addition, you can find the mission statement for the column and the email link to the column editor that I mentioned above. At the discretion of its editor, a feature column site may contain additional resources. As an example, the Chemical Information Instructor column edited by Arleen Somerville will have a periodically updated bibliography of resources for teaching and using chemical information. Due to the increase in the number of these resources available on the WWW, it only makes sense to publish this information online so that you can get to these resources with a simple click of the mouse. We expect that there will soon be additional information and resources at several other feature column sites. Following in the footsteps of the Chemical Information Instructor, up-to-date bibliographies and links to related online resources can be made available. We hope to extend the online component of our feature columns with moderated online discussion forums. If you have a suggestion for an online resource you would like to see included, let the feature editor or JCE Online (jceonline@chem.wisc.edu) know about it. JCE Internet Features JCE Internet also has several feature columns: Chemical Education Resource Shelf, Conceptual Questions and Challenge Problems, Equipment Buyers Guide, Hal's Picks, Mathcad

  9. Time Varying Feature Data

    Science.gov (United States)

    Echterhoff, J.; Simonis, I.; Atkinson, R.

    2012-04-01

    The infrastructure to gather, store and access information about our environment is improving and growing rapidly. The increasing amount of information allows us to get a better understanding of the current state of our environment, historical processes and to simulate and predict the future state of the environment. Finer grained spatial and temporal data and more reliable communications make it easier to model dynamic states and ephemeral features. The exchange of information within and across geospatial domains is facilitated through the use of harmonized information models. The Observations & Measurements (O&M) developed through OGC and standardised by ISO is an example of such a cross-domain information model. It is used in many domains, including meteorology, hydrology as well as the emergency management. O&M enables harmonized representation of common metadata that belong to the act of determining the state of a feature property, whether by sensors, simulations or humans. In addition to the resulting feature property value, information such as the result quality but especially the time that the result applies to the feature property can be represented. Temporal metadata is critical to modelling past and future states of a feature. The features, and the semantics of each property, are defined in domain specific Application Schema using the General Feature Model (GFM) from ISO 19109 and usually encoded following ISO 19136. However, at the moment these standards provide only limited support for the representation and handling of time varying feature data. Features like rivers, wildfires or gas plumes have a defined state - for example geographic extent - at any given point in time. To keep track of changes, a more complex model for example using time-series coverages is required. Furthermore, the representation and management of feature property value changes via the service interfaces defined by OGC and ISO - namely: WFS and WCS - would be rather complex

  10. Features of resilience

    Energy Technology Data Exchange (ETDEWEB)

    Connelly, Elizabeth B.; Allen, Craig R.; Hatfield, Kirk; Palma-Oliveira, José M.; Woods, David D.; Linkov, Igor

    2017-02-20

    The National Academy of Sciences (NAS) definition of resilience is used here to organize common concepts and synthesize a set of key features of resilience that can be used across diverse application domains. The features in common include critical functions (services), thresholds, cross-scale (both space and time) interactions, and memory and adaptive management. We propose a framework for linking these features to the planning, absorbing, recovering, and adapting phases identified in the NAS definition. The proposed delineation of resilience can be important in understanding and communicating resilience concepts.

  11. Feature selection in bioinformatics

    Science.gov (United States)

    Wang, Lipo

    2012-06-01

    In bioinformatics, there are often a large number of input features. For example, there are millions of single nucleotide polymorphisms (SNPs) that are genetic variations which determine the dierence between any two unrelated individuals. In microarrays, thousands of genes can be proled in each test. It is important to nd out which input features (e.g., SNPs or genes) are useful in classication of a certain group of people or diagnosis of a given disease. In this paper, we investigate some powerful feature selection techniques and apply them to problems in bioinformatics. We are able to identify a very small number of input features sucient for tasks at hand and we demonstrate this with some real-world data.

  12. 锡类散结肠溶胶囊对DSS诱导小鼠结肠炎的干预作用研究%The interference of XileiSan Jiechangrong capsule onDSS-induced ulcerative colitis in mice

    Institute of Scientific and Technical Information of China (English)

    王小平; 陈建章; 范伯曾

    2016-01-01

    mice colon were observed. The level of TNF-α and IL-l0 were assessed by immunohistochemical method. Results: Compared with the DSS model group, the SASP control group and the XileiSan Jiechangrong capsule group signiifcantly ameliorated the symptom of UC and histopathological, reduced colonic DAI, decreased the levels of colonic TNF-α and increased the levels of colonic IL-10. Conclusion: The XileiSan Jiechangrong capsule demonstrated good effects on ulcerative colitis induced DSS. It provided an experimental basis to the research and development of XileiSan Jiechangrong capsule.%Objective: To investigate efficacy of XileiSan Jiechangrong capsule on dextran sulphate sodium induced ulcerative colitis in mice. Methods: Forty male BALB/c mice were randomly divided into four groups: the normal group, the DSS model group, the Salazosulfapyridine control group, the XileiSan Jiechangrong capsule treatment group. Except for mice in the normal group, all mice were administered with 5% DSS solution, for 7 days to induce colitis. From 8th to 17th day, the normal group and the DSS model group were given normal saline by gavage daily; the SASP control group and the XileiSan Jiechangrong capsule treatment group were administered with SASP 0.4g·kg-1·d-1 and the XileiSan Jiechangrong capsule by gavage daily respectively. The body weight and stool consistency and occult or gross blood were recorded to calculate the disease activity index. The ratio of colon weight and length were evaluated. The macroscopic and histopathological changes of the mice colon were observed. The level of TNF-α and IL-l0 were assessed by immunohistochemical method. Results: Compared with the DSS model group, the SASP control group and the XileiSan Jiechangrong capsule group significantly ameliorated the symptom of UC and histopathological, reduced colonic DAI, decreased the levels of colonic TNF-α and increased the levels of colonic IL-10. Conclusion: The XileiSan Jiechangrong capsule demonstrated

  13. Fingerprint Feature Extraction Algorithm

    OpenAIRE

    Mehala. G

    2014-01-01

    The goal of this paper is to design an efficient Fingerprint Feature Extraction (FFE) algorithm to extract the fingerprint features for Automatic Fingerprint Identification Systems (AFIS). FFE algorithm, consists of two major subdivisions, Fingerprint image preprocessing, Fingerprint image postprocessing. A few of the challenges presented in an earlier are, consequently addressed, in this paper. The proposed algorithm is able to enhance the fingerprint image and also extractin...

  14. Fingerprint Feature Extraction Algorithm

    Directory of Open Access Journals (Sweden)

    Mehala. G

    2014-03-01

    Full Text Available The goal of this paper is to design an efficient Fingerprint Feature Extraction (FFE algorithm to extract the fingerprint features for Automatic Fingerprint Identification Systems (AFIS. FFE algorithm, consists of two major subdivisions, Fingerprint image preprocessing, Fingerprint image postprocessing. A few of the challenges presented in an earlier are, consequently addressed, in this paper. The proposed algorithm is able to enhance the fingerprint image and also extracting true minutiae.

  15. 肠黏膜细胞TLR9活化对DSS诱导小鼠溃疡性结肠炎模型的影响%Effects of Activated TLR9 in Intestinal Epithelium on Ulcerative Colitis Induced by DSS in Mice

    Institute of Scientific and Technical Information of China (English)

    孙鹏; 周晓晶; 刘伯岩; 杨文颖

    2012-01-01

    Objective To study the effect of activated TLR9 in intestinal epithelium on ulcerative colitis induced by DSS in mice.Method Mice were randomly divided into six groups:PBS group,CpG ODN group,control ODN group,DSS+PBS group,DSS+CpG ODN group and DSS+control ODN group.The mice in PBS group,CpG ODN group and control ODN group were fed normally and were injected intraperitoneally with PBS,CpG ODN,and control ODN,respectively.The mice in DSS+PBS group,DSS+CpG ODN group and DSS+control ODN group were fed with DSS in water for drinking and were injected intraperitoneally with PBS,CpG ODN,and control ODN,respectively.Disease active index(DAI)was recorded every day.After ten days the mice were killed and their colons were taken out to undergo histological examination.Results The loss of weight in DSS+CpG ODN group was more than those in other groups(P0.05).Moreover,the DAI score and histological score in the group of DSS+CpG ODN were significantly higher than those in other groups(P0.05).Conclusion The CpG ODN could aggravate the ulcerative colitis induced by DSS in mice.%目的研究肠黏膜细胞内TLR9的活化对DSS诱导小鼠溃疡性结肠炎的影响.方法将小鼠随机分为6组,分别为PBS组、CpG ODN组、对照 ODN组、DSS+PBS组、DSS+CpG ODN组和DSS+对照 ODN组.其中PBS组、CpG ODN组、对照 ODN组的小鼠正常喂养,在当天给这3组小鼠通过腹腔分别注射PBS、CpG ODN和CpG ODN的对照 ODN;而给予DSS+PBS组、DSS+CpG ODN组和DSS对照 ODN组小鼠喂饲含有DSS的水,同样于当天给这3组小鼠通过腹腔分别注射PBS、CpG ODN和CpG ODN的对照 ODN.每天观察各组小鼠的状态、大便性状及大便隐血情况,作DAI评分;记录小鼠体质量变化.于第10天处死小鼠,分离结肠组织,进行组织学评分.结果经观察及检测发现:DSS+CpG ODN组小鼠的体质量下降明显,且状态不佳,DAI评分及组织学评分最高.结论 CpG ODN可加重DSS诱导的小鼠溃疡性结肠炎

  16. Driver Fatigue Features Extraction

    Directory of Open Access Journals (Sweden)

    Gengtian Niu

    2014-01-01

    Full Text Available Driver fatigue is the main cause of traffic accidents. How to extract the effective features of fatigue is important for recognition accuracy and traffic safety. To solve the problem, this paper proposes a new method of driver fatigue features extraction based on the facial image sequence. In this method, first, each facial image in the sequence is divided into nonoverlapping blocks of the same size, and Gabor wavelets are employed to extract multiscale and multiorientation features. Then the mean value and standard deviation of each block’s features are calculated, respectively. Considering the facial performance of human fatigue is a dynamic process that developed over time, each block’s features are analyzed in the sequence. Finally, Adaboost algorithm is applied to select the most discriminating fatigue features. The proposed method was tested on a self-built database which includes a wide range of human subjects of different genders, poses, and illuminations in real-life fatigue conditions. Experimental results show the effectiveness of the proposed method.

  17. Feature Technology in Product Modeling

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xu; NING Ruxin

    2006-01-01

    A unified feature definition is proposed. Feature is form-concentrated, and can be used to model product functionalities, assembly relations, and part geometries. The feature model is given and a feature classification is introduced including functional, assembly, structural, and manufacturing features. A prototype modeling system is developed in Pro/ENGINEER that can define the assembly and user-defined form features.

  18. Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor – evidence that furanosyl borate diester (AI-2 is influencing the cytokine expression in the DSS colitis mouse model

    Directory of Open Access Journals (Sweden)

    Jacobi Christoph A

    2012-08-01

    Full Text Available Abstract Background “Quorum sensing” (QS is the phenomenon which allows single bacterial cells to measure the concentration of bacterial signal molecules. Two principle different QS systems are known, the Autoinducer 1 system (AI-1 for the intraspecies communication using different Acyl-homoserine lactones (AHL and AI-2 for the interspecies communication. Aim of this study was to investigate QS of Escherichia coli Nissle 1917 (Mutaflor. Results While E. coli Nissle is producing AI-2 in a density dependent manner, no AI-1 was produced. To study the effect of AI-2 in the DSS (dextran sulphate sodium induced mouse model of acute colitis, we silenced the corresponding gene luxS by intron insertion. The mutant bacterium E. coli Nissle::luxS was equally effective in colonizing the colon and the mutation turned out to be 100% stable during the course of the experiment. Isolating RNA from the colon mucosa and performing semiquantitative RT PCR, we were able to show that the expression of the pro-inflammatory cytokine IFN-y was suppressed in mice being infected with the E. coli Nissle wild type. Mice infected with the E. coli Nissle::luxS mutant showed a suppressed expression of IL-10 compared to uninfected mice, while the expression of the pro-inflammatory cytokines IL-6 and TNF-α was higher in these mice. The expression of mBD-1 was suppressed in mice being infected with the mutant in comparison to the mice not infected or infected with the wild type. No differences were seen in the histological examination of the colon sections in the different groups of mice. Conclusions E. coli Nissle is producing AI-2 molecules, which are influencing the expression of cytokines in the mucosa of the colon in the DSS mice. However, if QS has a direct influence on the probiotic properties of E. coli Nissle remains to be elucidated.

  19. Framework Study of the Air Force Communication Equipments Technical Support DSS Based on DW%基于DW的空军通信装备技术保障DSS的框架研究

    Institute of Scientific and Technical Information of China (English)

    黄敬杯; 雷志雄; 李金良

    2011-01-01

    Aiming at the current situation of the Air Force communication equipments technical support, like lacks of ability and ways of decision support are backward etc, the Air Force communication equipments technical support DSS which based on data warehouse is put forward and the system's framework is built. Meanwhile, the system warehouse is designed, the metadata and ETL (extract, translate, load) module are designed and built as well. In the end, the system's development process is introduced briefly. The system will turn communication equipments technical support data to decision information and enhance the efficiency of the Air Force communication equipments technical support significantly.%针对空军通信装备技术保障存在能力不足、决策支持手段落后等现状,提出了基于数据仓库(data warehouse,DW)的空军通信装备技术保障决策支持系统(decision support system,DSS)并构建了其整体架构,完成了系统DW设计,建构了系统元数据和数据抽取、转换、加载(extract,transform,load,ETL)的ETL模型,最后简述了系统的开发过程。该系统能有效地将通信装备技术保障数据转化为科学的决策信息,提高空军通信装备技术保障的效能。

  20. Searchable solar feature catalogues

    Science.gov (United States)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    The searchable Solar Feature Catalogues (SFCs) are developed from digitized solar images using automated pattern recognition techniques. The techniques were applied for the detection of sunspots, active regions, filaments and line-of-sight magnetic neutral lines in automatically standardized full disk solar images in Ca II K1, Ca II K3 and Ha lines taken at the Paris-Meudon Observatory and white light images and magnetograms from SOHO/MDI. The results of the automated recognition were verified with manual synoptic maps and available statistical data that revealed good detection accuracy. Based on the recognized parameters, a structured database of Solar Feature Catalogues was built on a MySQL server for every feature and published with various pre-designed search pages on the Bradford University web site http://www.cyber.brad.ac.uk/egso/SFC/. The SFCs with nine year coverage (1996-2004) is to be used for deeper investigation of the feature classification and solar activity forecast.

  1. Live facial feature extraction

    Institute of Scientific and Technical Information of China (English)

    ZHAO JieYu

    2008-01-01

    Precise facial feature extraction is essential to the high-level face recognition and expression analysis. This paper presents a novel method for the real-time geomet-ric facial feature extraction from live video. In this paper, the input image is viewed as a weighted graph. The segmentation of the pixels corresponding to the edges of facial components of the mouth, eyes, brows, and nose is implemented by means of random walks on the weighted graph. The graph has an 8-connected lattice structure and the weight value associated with each edge reflects the likelihood that a random walker will cross that edge. The random walks simulate an anisot-ropic diffusion process that filters out the noise while preserving the facial expres-sion pixels. The seeds for the segmentation are obtained from a color and motion detector. The segmented facial pixels are represented with linked lists in the origi-nal geometric form and grouped into different parts corresponding to facial com-ponents. For the convenience of implementing high-level vision, the geometric description of facial component pixels is further decomposed into shape and reg-istration information. Shape is defined as the geometric information that is invari-ant under the registration transformation, such as translation, rotation, and iso-tropic scale. Statistical shape analysis is carried out to capture global facial fea-tures where the Procrustes shape distance measure is adopted. A Bayesian ap-proach is used to incorporate high-level prior knowledge of face structure. Ex-perimental results show that the proposed method is capable of real-time extraction of precise geometric facial features from live video. The feature extraction is robust against the illumination changes, scale variation, head rotations, and hand inter-ference.

  2. 3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome.

    Science.gov (United States)

    Wang, Yajing; Wang, Hong; Qian, Chen; Tang, Jingjing; Zhou, Wei; Liu, Xiuting; You, Qidong; Hu, Rong

    2016-02-01

    NLRP3 inflammasome is a key component of the inflammatory process and its dysregulation contributes to IBD for its ability to induce IL-1β release. Previously, we reported that a novel small molecular activator of Nrf2, 3-(2-oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino-[2,1-a]isoquinolin-4(11bH)-one (compound 1) can prevent the development of colorectal adenomas in AOM-DSS models. Here we further investigated the anti-inflammatory effect of compound 1 in DSS-induced colitis in C57BL/6 and NLRP3(-/-) mice, and revealed the possible modulation by compound 1 of NLRP3 inflammasome-mediated IL-1β release from macrophages. In C57BL/6 mice, oral administration of compound 1 significantly attenuated DSS-induced colonic pathological damage, remarkably inhibited inflammatory cells infiltration and decreased myeloperoxidase (MPO) and IL-1β secretion in colons. In contrast, mice deficient for NLRP3 were less sensitive to DSS-induced acute colitis, and compound 1 treatment exerted no protective effect on DSS-induced intestinal inflammation in NLRP3(-/-) mice. The protective effect of compound 1 may be attributed to its inhibition of NLRP3 inflammasome and Nrf2 activation in colons. Furthermore, compound 1, as a small molecular activator of Nrf2, significantly inhibited NLRP3 inflammasome activation in both THP-1 derived macrophages and bone-marrow derived macrophages, as indicated by reduced expression of NLRP3 and cleaved caspase-1, and lowered IL-1β secretion. Finally, compound 1-induced NLRP3 inflammasome inhibition is through blocking NLRP3 priming step and dependent on Nrf2 activation. Taken together, our findings demonstrate that compound 1 might be a potential agent for the treatment of IBD by targeting Nrf2 and NLRP3 inflammasome.

  3. Major depression with psychotic features

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000933.htm Major depression with psychotic features To use the sharing features on this page, please enable JavaScript. Major depression with psychotic features is a mental disorder in ...

  4. Features of Women's language

    Institute of Scientific and Technical Information of China (English)

    何延凌

    2008-01-01

    Language is a means of verbal communication.People use language to communicate with each other.In the society,no two speakers are exactly alike in the way of speaking.Some differences are due to age,gender,statue and personality. Above all,gender is one of the obvious reasons.The writer of this paper tries to describe the features of women's language from these perspectives: pronunciation,intonation,diction,subjects,grammar and discourse.From the discussion of the features of women's language,more attention should be paid to language use in social context.What's more,the linguistic phenomena in a speaking community can be understood more thoroughly.

  5. Imaging features of thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Tunaci, M.; Tunaci, A.; Engin, G.; Oezkorkmaz, B.; Acunas, G.; Acunas, B. [Dept. of Radiology, Istanbul Univ. (Turkey); Dincol, G. [Dept. of Internal Medicine, Istanbul Univ. (Turkey)

    1999-07-01

    Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of {beta}-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings. (orig.)

  6. Features or tasks?

    DEFF Research Database (Denmark)

    Heilesen, Simon

    In this paper for the Workshop on Human-computer interaction and e-learning, NordiCHI 2002, the author argues that in developing innovative E-learning systems, especially if constructivist pedagogy is to be applied, it will be useful to model the user interface on the often complex tasks...... that the user has to perform rather than just focusing on technical features (and adapting system use to them)....

  7. Functions & Features of Idioms

    Institute of Scientific and Technical Information of China (English)

    周来纳

    2015-01-01

    Idioms, or conventionalized multiword expressions, often but not always non-literal, are hardly marginal in English, though they have been relatively neglected in lexical studies of the language. This neglect is especially evident in respect of the functions of idioms. The aim of this article, accordingly, is to account for the functions of idioms by analyzing what they do with the features of idioms.

  8. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas;

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  9. Zone-size nonuniformity of {sup 18}F-FDG PET regional textural features predicts survival in patients with oropharyngeal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Nai-Ming [Chang Gung Memorial Hospital and Chang Gung University, Departments of Nuclear Medicine, Taiyuan (China); Chang Gung Memorial Hospital, Department of Nuclear Medicine, Keelung (China); National Tsing Hua University, Department of Biomedical Engineering and Environmental Sciences, Hsinchu (China); Fang, Yu-Hua Dean [Chang Gung University, Department of Electrical Engineering, Taiyuan (China); Lee, Li-yu [Chang Gung University College of Medicine, Department of Pathology, Chang Gung Memorial Hospital, Taoyuan (China); Chang, Joseph Tung-Chieh; Tsan, Din-Li [Chang Gung University College of Medicine, Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan (China); Ng, Shu-Hang [Chang Gung University College of Medicine, Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan (China); Wang, Hung-Ming [Chang Gung University College of Medicine, Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan (China); Liao, Chun-Ta [Chang Gung University College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan (China); Yang, Lan-Yan [Chang Gung Memorial Hospital, Biostatistics Unit, Clinical Trial Center, Taoyuan (China); Hsu, Ching-Han [National Tsing Hua University, Department of Biomedical Engineering and Environmental Sciences, Hsinchu (China); Yen, Tzu-Chen [Chang Gung Memorial Hospital and Chang Gung University, Departments of Nuclear Medicine, Taiyuan (China); Chang Gung University College of Medicine, Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taipei (China)

    2014-10-23

    The question as to whether the regional textural features extracted from PET images predict prognosis in oropharyngeal squamous cell carcinoma (OPSCC) remains open. In this study, we investigated the prognostic impact of regional heterogeneity in patients with T3/T4 OPSCC. We retrospectively reviewed the records of 88 patients with T3 or T4 OPSCC who had completed primary therapy. Progression-free survival (PFS) and disease-specific survival (DSS) were the main outcome measures. In an exploratory analysis, a standardized uptake value of 2.5 (SUV 2.5) was taken as the cut-off value for the detection of tumour boundaries. A fixed threshold at 42 % of the maximum SUV (SUV{sub max} 42 %) and an adaptive threshold method were then used for validation. Regional textural features were extracted from pretreatment {sup 18}F-FDG PET/CT images using the grey-level run length encoding method and grey-level size zone matrix. The prognostic significance of PET textural features was examined using receiver operating characteristic (ROC) curves and Cox regression analysis. Zone-size nonuniformity (ZSNU) was identified as an independent predictor of PFS and DSS. Its prognostic impact was confirmed using both the SUV{sub max} 42 % and the adaptive threshold segmentation methods. Based on (1) total lesion glycolysis, (2) uniformity (a local scale texture parameter), and (3) ZSNU, we devised a prognostic stratification system that allowed the identification of four distinct risk groups. The model combining the three prognostic parameters showed a higher predictive value than each variable alone. ZSNU is an independent predictor of outcome in patients with advanced T-stage OPSCC, and may improve their prognostic stratification. (orig.)

  10. Feature Engineering for Drug Name Recognition in Biomedical Texts: Feature Conjunction and Feature Selection

    Directory of Open Access Journals (Sweden)

    Shengyu Liu

    2015-01-01

    Full Text Available Drug name recognition (DNR is a critical step for drug information extraction. Machine learning-based methods have been widely used for DNR with various types of features such as part-of-speech, word shape, and dictionary feature. Features used in current machine learning-based methods are usually singleton features which may be due to explosive features and a large number of noisy features when singleton features are combined into conjunction features. However, singleton features that can only capture one linguistic characteristic of a word are not sufficient to describe the information for DNR when multiple characteristics should be considered. In this study, we explore feature conjunction and feature selection for DNR, which have never been reported. We intuitively select 8 types of singleton features and combine them into conjunction features in two ways. Then, Chi-square, mutual information, and information gain are used to mine effective features. Experimental results show that feature conjunction and feature selection can improve the performance of the DNR system with a moderate number of features and our DNR system significantly outperforms the best system in the DDIExtraction 2013 challenge.

  11. Feature engineering for drug name recognition in biomedical texts: feature conjunction and feature selection.

    Science.gov (United States)

    Liu, Shengyu; Tang, Buzhou; Chen, Qingcai; Wang, Xiaolong; Fan, Xiaoming

    2015-01-01

    Drug name recognition (DNR) is a critical step for drug information extraction. Machine learning-based methods have been widely used for DNR with various types of features such as part-of-speech, word shape, and dictionary feature. Features used in current machine learning-based methods are usually singleton features which may be due to explosive features and a large number of noisy features when singleton features are combined into conjunction features. However, singleton features that can only capture one linguistic characteristic of a word are not sufficient to describe the information for DNR when multiple characteristics should be considered. In this study, we explore feature conjunction and feature selection for DNR, which have never been reported. We intuitively select 8 types of singleton features and combine them into conjunction features in two ways. Then, Chi-square, mutual information, and information gain are used to mine effective features. Experimental results show that feature conjunction and feature selection can improve the performance of the DNR system with a moderate number of features and our DNR system significantly outperforms the best system in the DDIExtraction 2013 challenge.

  12. Abdominal tuberculosis: Imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Jose M. [Department of Radiology, Hospital de S. Joao, Porto (Portugal)]. E-mail: jmpjesus@yahoo.com; Madureira, Antonio J. [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Vieira, Alberto [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Ramos, Isabel [Department of Radiology, Hospital de S. Joao, Porto (Portugal)

    2005-08-01

    Radiological findings of abdominal tuberculosis can mimic those of many different diseases. A high level of suspicion is required, especially in high-risk population. In this article, we will describe barium studies, ultrasound (US) and computed tomography (CT) findings of abdominal tuberculosis (TB), with emphasis in the latest. We will illustrate CT findings that can help in the diagnosis of abdominal tuberculosis and describe imaging features that differentiate it from other inflammatory and neoplastic diseases, particularly lymphoma and Crohn's disease. As tuberculosis can affect any organ in the abdomen, emphasis is placed to ileocecal involvement, lymphadenopathy, peritonitis and solid organ disease (liver, spleen and pancreas). A positive culture or hystologic analysis of biopsy is still required in many patients for definitive diagnosis. Learning objectives:1.To review the relevant pathophysiology of abdominal tuberculosis. 2.Illustrate CT findings that can help in the diagnosis.

  13. Multispectral Image Feature Points

    Directory of Open Access Journals (Sweden)

    Cristhian Aguilera

    2012-09-01

    Full Text Available This paper presents a novel feature point descriptor for the multispectral image case: Far-Infrared and Visible Spectrum images. It allows matching interest points on images of the same scene but acquired in different spectral bands. Initially, points of interest are detected on both images through a SIFT-like based scale space representation. Then, these points are characterized using an Edge Oriented Histogram (EOH descriptor. Finally, points of interest from multispectral images are matched by finding nearest couples using the information from the descriptor. The provided experimental results and comparisons with similar methods show both the validity of the proposed approach as well as the improvements it offers with respect to the current state-of-the-art.

  14. Feature tracking and aging

    Directory of Open Access Journals (Sweden)

    Rémy eAllard

    2013-07-01

    Full Text Available There are conflicting results regarding the effect of aging on second-order motion processing (i.e., motion defined by attributes other than luminance, such as contrast. Two studies (Habak & Faubert, 2000; Tang & Zhou, 2009 found that second-order motion processing was more vulnerable to aging than first-order motion processing. Conversely, Billino, Braun, Bremmer and Gegenfurtner (2011 recently found that aging affected first- and second-order motion processing by similar proportions. These three studies used contrast-defined motion as a second-order stimulus, but there can be at least two potential issues when using such a stimulus to evaluate age-related sensitivity losses. First, it has been shown that the motion system processing contrast-defined motion varies depending on the stimulus parameters. Thus, although all these three studies assumed that their contrast-defined motion was processed by a low-level second-order motion system, this was not necessarily the case. The second potential issue is that contrast-defined motion consists in a contrast modulation of a texture rich in high spatial frequencies and aging mainly affects contrast sensitivity at high spatial frequencies. Consequently, some age-related sensitivity loss to second-order motion could be due to a lower sensitivity to the texture rather than to motion processing per se. To avoid these two potential issues, we used a second-order motion stimulus void of high spatial frequencies and which has been shown to be processed by a high-level feature tracking motion system, namely fractal rotation (Lagacé-Nadon, Allard, & Faubert, 2009. We found an age-related deficit on second-order motion processing at all temporal frequencies including the ones for which no age-related effect on first-order motion processing was observed. We conclude that aging affects the ability to track features. Previous age-related results on second-order and global motion processing are discussed in light

  15. 面向过程挖掘的C4.5在营销决策支持系统中的应用%The Application of C4.5 Professes Mining Oriented in Marketing DSS

    Institute of Scientific and Technical Information of China (English)

    钱峰; 程鸿芳; 陶维成

    2012-01-01

    In the entire process of marketing, it determines that what type of products is more suitable for the market demand in high, medium and low - grade products from the target market. The enterprises adjust the product structure to the change of market in complicated market conditions according to the judgment. In this paper, the system imports the original MIS data processed into data warehouse to form structured data adopting the data miner C4. 5 arithmetic. It analysis and evaluates the mining result on data mining methods, and gives assistant decision scope to DSS fully.%产品营销过程中,企业需从目标市场中判断高、中、低档产品,哪类更适合其市场需求,以此可使在复杂的市场环境下及时调整产品结构,适应市场需求变化。本文采用数据挖掘C4.5算法,将原有的硒数据经处理后,导入到数据仓库中形成结构化数据,采用过程挖掘的方法对挖掘结果进行分析和评估,充分发挥决策支持系统的辅助决策作用。

  16. Genomic Feature Models

    DEFF Research Database (Denmark)

    Sørensen, Peter; Edwards, Stefan McKinnon; Rohde, Palle Duun

    Whole-genome sequences and multiple trait phenotypes from large numbers of individuals will soon be available in many populations. Well established statistical modeling approaches enable the genetic analyses of complex trait phenotypes while accounting for a variety of additive and non-additive g......Whole-genome sequences and multiple trait phenotypes from large numbers of individuals will soon be available in many populations. Well established statistical modeling approaches enable the genetic analyses of complex trait phenotypes while accounting for a variety of additive and non......-additive genetic mechanisms. These modeling approaches have proven to be highly useful to determine population genetic parameters as well as prediction of genetic risk or value. We present a series of statistical modelling approaches that use prior biological information for evaluating the collective action...... of sets of genetic variants. We have applied these approaches to whole genome sequences and a complex trait phenotype resistance to starvation collected on inbred lines from the Drosophila Genome Reference Panel population. We identified a number of genomic features classification schemes (e.g. prior QTL...

  17. Image feature localization by multiple hypothesis testing of Gabor features.

    Science.gov (United States)

    Ilonen, Jarmo; Kamarainen, Joni-Kristian; Paalanen, Pekka; Hamouz, Miroslav; Kittler, Josef; Kälviäinen, Heikki

    2008-03-01

    Several novel and particularly successful object and object category detection and recognition methods based on image features, local descriptions of object appearance, have recently been proposed. The methods are based on a localization of image features and a spatial constellation search over the localized features. The accuracy and reliability of the methods depend on the success of both tasks: image feature localization and spatial constellation model search. In this paper, we present an improved algorithm for image feature localization. The method is based on complex-valued multi resolution Gabor features and their ranking using multiple hypothesis testing. The algorithm provides very accurate local image features over arbitrary scale and rotation. We discuss in detail issues such as selection of filter parameters, confidence measure, and the magnitude versus complex representation, and show on a large test sample how these influence the performance. The versatility and accuracy of the method is demonstrated on two profoundly different challenging problems (faces and license plates).

  18. Finding phonological features in perception

    NARCIS (Netherlands)

    Chládková, K.

    2014-01-01

    This thesis investigated whether phonological features have perceptual bases. The search for features in perception was approached from several angles: from that of an adult listener who has a fully acquired language system in place, from that of a linguist who aims to uncover feature structures in

  19. Reconstructing NURBS Surface with Features

    Institute of Scientific and Technical Information of China (English)

    SUN Chunhua

    2006-01-01

    The method of reconstructing NURBS surface with features is proposed in this paper. Features including boundary curves and feature points are recognized from the scanned data. An initial surface is constructed with boundary curves. The desired NURBS is determined by modifying the initial surface to pass through feature points. Lagrange multiplier is used to find the solution. The error analysis is then done. Examples are given to verify the algorithm at last. The method can keep some features fixed and be widely used in CAD modeling.

  20. Confidence-Based Feature Acquisition

    Science.gov (United States)

    Wagstaff, Kiri L.; desJardins, Marie; MacGlashan, James

    2010-01-01

    Confidence-based Feature Acquisition (CFA) is a novel, supervised learning method for acquiring missing feature values when there is missing data at both training (learning) and test (deployment) time. To train a machine learning classifier, data is encoded with a series of input features describing each item. In some applications, the training data may have missing values for some of the features, which can be acquired at a given cost. A relevant JPL example is that of the Mars rover exploration in which the features are obtained from a variety of different instruments, with different power consumption and integration time costs. The challenge is to decide which features will lead to increased classification performance and are therefore worth acquiring (paying the cost). To solve this problem, CFA, which is made up of two algorithms (CFA-train and CFA-predict), has been designed to greedily minimize total acquisition cost (during training and testing) while aiming for a specific accuracy level (specified as a confidence threshold). With this method, it is assumed that there is a nonempty subset of features that are free; that is, every instance in the data set includes these features initially for zero cost. It is also assumed that the feature acquisition (FA) cost associated with each feature is known in advance, and that the FA cost for a given feature is the same for all instances. Finally, CFA requires that the base-level classifiers produce not only a classification, but also a confidence (or posterior probability).