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Sample records for argentine radioprotection society

  1. Experience of the Argentine Radioprotection Society in training in radiological protection

    International Nuclear Information System (INIS)

    From its creation in 1967, the Argentine Radioprotection Society (SAR) has as basic purpose promoting all the aspects related with the radiological protection and the nuclear safety. Due to the great increment in the use of radioactive sources in diverse areas, soon it was evident for the SAR the importance and necessity to promote the knowledge of the radioprotection approaches between the users of radioactive sources and ionizing radiations in all its application fields, be these industrial, academic or doctors. From the year 2000, the SAR comes organizing in regular and periodical form basic and specialized courses about radiological safety of radioactive sources for industrial use and profile of oil wells, among others. In this work, the characteristics of the different dictated courses are described whose programs have been developed keeping in mind the requirements of the competent authorities of Argentina. Also, statistical information on the dictated courses and its participants is presented. The number of dictated courses was incremented from 6 (year 2000) up to 16 (year 2005), being also increased significantly the number of participants for course. The dictated courses are theoretical-practical, with a duration average of 20 hs. The educational body is constituted by specialists in the different topics with recognized experience. Its given to the participants notes and support material, as well as copies of the material presented to develop the course. When concluding the courses, its deliver to the participants certifies of attendance and/or approval, as it corresponds. In their headquarters the SAR has didactic facilities and specific equipment for the dictation of the courses. Also accounts with the easiness of dictating those courses outside of their headquarters. This is particularly advantageous for companies or organizations that are seated in points far from the main cities and they should qualify in radiological safety to the personnel but, by

  2. Experience of the Argentine Radioprotection Society in training in radiological protection; Experiencia de la Sociedad Argentina de radioproteccion en capacitacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Bomben, A.M. [Sociedad Argentina de Radioproteccion (SAR), Av. del Libertador 8250 of. 122, (1429), Buenos Aires (Argentina)]. e-mail: abomben@sede.arn.gov.ar

    2006-07-01

    From its creation in 1967, the Argentine Radioprotection Society (SAR) has as basic purpose promoting all the aspects related with the radiological protection and the nuclear safety. Due to the great increment in the use of radioactive sources in diverse areas, soon it was evident for the SAR the importance and necessity to promote the knowledge of the radioprotection approaches between the users of radioactive sources and ionizing radiations in all its application fields, be these industrial, academic or doctors. From the year 2000, the SAR comes organizing in regular and periodical form basic and specialized courses about radiological safety of radioactive sources for industrial use and profile of oil wells, among others. In this work, the characteristics of the different dictated courses are described whose programs have been developed keeping in mind the requirements of the competent authorities of Argentina. Also, statistical information on the dictated courses and its participants is presented. The number of dictated courses was incremented from 6 (year 2000) up to 16 (year 2005), being also increased significantly the number of participants for course. The dictated courses are theoretical-practical, with a duration average of 20 hs. The educational body is constituted by specialists in the different topics with recognized experience. Its given to the participants notes and support material, as well as copies of the material presented to develop the course. When concluding the courses, its deliver to the participants certifies of attendance and/or approval, as it corresponds. In their headquarters the SAR has didactic facilities and specific equipment for the dictation of the courses. Also accounts with the easiness of dictating those courses outside of their headquarters. This is particularly advantageous for companies or organizations that are seated in points far from the main cities and they should qualify in radiological safety to the personnel but, by

  3. Argentine radiation protection society

    International Nuclear Information System (INIS)

    The Argentine Radiation Protection Society (SAR) is a non profit society, member of IRPA. It was originally launched in 1987 and a formal constitution was adopted in 1983. Presently, SAR has 220 active members, professionals and technicians dedicated to a variety of disciplines related to different radiation protection aspects: medicine, industry, research and teaching. The basic SAR objectives are: to promote research and knowledge exchange on radiation protection topics and related disciplines; to promote the comprehension of radiation protection criteria with regard to existence and handling of radioactive and fissile materials and any other radiation sources; to foster the conception of radiation protection as a professional discipline and to contribute to its permanent improvement; to promote the diffusion of the information related to all radiation protection and nuclear safety aspects, and radiation protection standards and recommendations, not only within the scientific, technical and academic areas, but also to general public

  4. Argentine Radiation Protection Society Experience in RP education and training

    International Nuclear Information System (INIS)

    Since its creation in 1967, the Argentine Radiation Protection Society (SAR) promotes all the radiation protection and nuclear safety aspects not only within the scientific, technical and academic areas, but also to general public. To fulfill this objective, SAR organised training and refresher courses, seminars and workshops on RP subjects. During 2002, SAR organised 7 basic and specialized courses regarding the uses of radioactive materials in industrial applications and the course on medical response in radiological accidents, that was attended by Argentine and other Latin American participants. The programmes of the courses are developed in compliance with the legal requirements and also considering specifics needs. In this paper, the characteristics of the courses are enunciated and basic statistics regarding courses and participants are presented. For the 2003 and 2004, SAR foresees the organisation of 18 courses per year and has the capacity to deliver other courses by request. all the courses are delivered in Spanish language. Based on this educational experience SAR consider a priority the inclusion, of a RP module in all the scientific graduate programmes to generate awareness on the importance of RP. Taking into account the migration of professionals to Europe and North America and the Globalization, SAR advocates the harmonization of RP syllabus to attain an international recognition. (Author)

  5. Radioprotection

    International Nuclear Information System (INIS)

    A major feature of all higher eukaryotes is the defined life span of the organism. Radioprotections are substances that protect the cells against Radiation induced damage. Over the past decade interest in evaluating oriental medicinal herbs and edible phytoproducts for use in Cancer preventing strategies is encouraging and emerging as an acceptable approach for controlling the Cancer incidence in many developing countries as well as developed countries. Several experimental evidence has indicated that intake of fruit and vegetables and a number of other dietary items are associated with decreased Cancer incidence. These potential agents either abolish or delay the development of Cancer by interfering with one or more steps in the process of carcinogenesis, such as preventing the activation of carcinogen by increasing detoxification or by blocking the interaction of ultimate carcinogen with cellular macromolecules or suppressing the clonal expansion of neoplastic cells. The potential of using medicinal herbs as Cancer chemo preventive neutraceuticals and functional food is promising. Radioprotective potential of extracts of certain dietary botanicals including Mentha arvensi (field mint), Syzyzium cumini (Jamun), Zingiber officinale (Ginger), Aegle marmelos (Bael), Emblica officianalis (Amla), Aloe vera (Gwar patha), Moringa oleifera (Moringa, Horse Radish Tree), Grewia asiatica (Phalsa), Rosemarinus officinalis (Rosemary), Trigonella foenum-graecum, Ocirnurn sanctum, Phylanthus niruri, Vetiveria zizanioides (vetivergrass), Delbergia sisso oil (Sesame oil) was evaluated. All botanicals tested had shown a very low toxicity. Administration of these botanicals increased the survival of whole body irradiated mice and reduced the symptoms of radiation sickness. (author)

  6. 7. national congress of radioprotection - SFRP 2009

    International Nuclear Information System (INIS)

    This document gathers the slides of the available presentations given during this conference. Sixty six presentations out of 68 are assembled in the document. The conference is organized in 11 sessions dealing with: 1 - radioprotection regulations and standards; 2 - radioprotection of patients; 3 - radiation effects on man and ecosystems; 4 - advances in dosimetry and metrology; occupational radioprotection (2 sessions); 5 - radioprotection of populations and ecosystems (2 sessions); 6 - radioprotection in incident, accident and post-accident situations; 7 - radioprotection and society

  7. Meditation and Dance in Creative Society: Contemplative Consciousness in Daoism, Zen and Argentine Tango

    Directory of Open Access Journals (Sweden)

    Agnieška Juzefovič

    2015-07-01

    Full Text Available This paper deals with the particularly relevant topic in the contemporary society – Asian meditative practices and methods of self-development. The first chapter deals with the notion of contemplative, enlightened consciousness in Daoism and Zen. The second chapter shows how meditative consciousness could be achieved through social tango. Six theses are argued as appropriate for both Daoism and Zen as well as tango: 1 contemplative, purified consciousness is empty of disturbing thoughts and focused toward the essence; 2 contemplative, purified consciousness is not only empty but also brimming full; 3 contemplative, purified consciousness is identical with everyday mind; 4 contemplative mind is functioning according to the principles of non-action and naturalness; 5 meditation leads toward the unity and integrity of consciousness and body, consciousness and outside world; 6 active meditation is an effective way to obtain aims mentioned above. The argumentation of such thesis helps to show that tango is akin to various meditative practices. So it could not only be successfully used as a form of entertainment but also as a meditative practice, leading toward aims, similar to those of Zen meditations.

  8. Proceedings of the 6. Argentine congress on radiation protection and nuclear safety

    International Nuclear Information System (INIS)

    The 6th Argentine Congress on Radiation Protection and Nuclear Safety was organized by the Radioprotection Argentine Society, in Buenos Aires, between the 22 and 24 of september of 1998. In this event, were presented almost 66 papers in the following sessions, about these subjects: 1.- Safety in nuclear installations. 2.- Control of nuclear material and physical protection of nuclear installations. 3.- Programs of quality assurance. 4.- Training, technical information and public information. 5.- Physical dosimetry. 6.- Physical dosimetry and occupational radiation protection. 7.- Exposure of the natural radiation. 8.- Environmental radiological safety. 9.- Biological effects of the ionizing radiations and biological dosimetry. 10.- Radiological protection of the medical practice and the radiological emergencies. 11.- Radioactive wastes management. 12.- Transport of radioactive materials

  9. Argentine Radiation Protection Society Experience in RP education and training; Experiencia de la Sociedad Argentina de Radioproteccion en capacitacion en Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Bomben, A. M.; Ciallella, N. R.; Thomasz, E.; Rudelli, M.; Gisone, P.; Ventura, M.; Gomez Parada, I.; Signoretta, C.

    2003-07-01

    Since its creation in 1967, the Argentine Radiation Protection Society (SAR) promotes all the radiation protection and nuclear safety aspects not only within the scientific, technical and academic areas, but also to general public. To fulfill this objective, SAR organised training and refresher courses, seminars and workshops on RP subjects. During 2002, SAR organised 7 basic and specialized courses regarding the uses of radioactive materials in industrial applications and the course on medical response in radiological accidents, that was attended by Argentine and other Latin American participants. The programmes of the courses are developed in compliance with the legal requirements and also considering specifics needs. In this paper, the characteristics of the courses are enunciated and basic statistics regarding courses and participants are presented. For the 2003 and 2004, SAR foresees the organisation of 18 courses per year and has the capacity to deliver other courses by request. all the courses are delivered in Spanish language. Based on this educational experience SAR consider a priority the inclusion, of a RP module in all the scientific graduate programmes to generate awareness on the importance of RP. Taking into account the migration of professionals to Europe and North America and the Globalization, SAR advocates the harmonization of RP syllabus to attain an international recognition. (Author)

  10. Radioprotective Agents

    Directory of Open Access Journals (Sweden)

    Ilker Kelle

    2008-01-01

    Full Text Available Since1949, a great deal of research has been carried out on the radioprotective activity of various chemical substances. Thiol compounds, compounds which contain –SH radical, different classes of pharmacological agents and other compounds such as vitamine C and WR-2721 have been shown to reduce mortality when administered prior to exposure to a lethal dose of radiation. Recently, honey bee venom as well as that of its components melittin and histamine have shown to be valuable in reduction of radiation-induced damage and also provide prophylactic alternative treatment for serious side effects related with radiotherapy. It has been suggested that the radioprotective activity of bee venom components is related with the stimulation of the hematopoetic system.

  11. Radioprotection by metals: Selenium

    Science.gov (United States)

    Weiss, J. F.; Srinivasan, V.; Kumar, K. S.; Landauer, M. R.

    The need exists for compounds that will protect individuals from high-dose acute radiation exposure in space and for agents that might be less protective but less toxic and longer acting. Metals and metal derivatives provide a small degree of radioprotection (dose reduction factor salt, sodium selenite, and the organic Se compound, selenomethionine, enhance the survival of irradiated mice (60Co, 0.2 Gy/min) when injected IP either before (-24 hr and -1 hr) or shortly after (+15 min) radiation exposure. When administered at equitoxic doses (one-fourth LD10; selenomethionine = 4.0 mg/kg Se, sodium selenite = 0.8 mg/kg Se), both drugs enhanced the 30-day survival of mice irradiated at 9 Gy. Survival after 10-Gy exposure was significantly increased only after selenomethionine treatment. An advantage of selenomethionine is lower lethal and behavioral toxicity (locomotor activity depression) compared to sodium selenite, when they are administered at equivalent doses of Se. Sodium selenite administered in combination with WR-2721, S-2-(3-aminopropylamino)ethylphosphorothioic acid, enhances the radioprotective effect and reduces the lethal toxicity, but not the behavioral toxicity, of WR-2721. Other studies on radioprotection and protection against chemical carcinogens by different forms of Se are reviewed. As additional animal data and results from human chemoprevention trials become available, consideration also can be given to prolonged administration of Se compounds for protection against long-term radiation effects in space.

  12. Radioprotection: mechanism and radioprotective agents including honeybee venom

    International Nuclear Information System (INIS)

    Since 1949, a great deal of research has been carried on the radioprotective action of chemical substances. These substances have shown to reduce mortality when administered to animals prior to exposure to a lethal dose of radiation. This fact is of considerable importance since it permits reduction of radiation-induced damage and provides prophylactic treatment for the damaging effects produced by radiotherapy. The following radioprotection mechanisms were proposed: free radical scavenger, repair by hydrogen donation to target molecules formation of mixed disulfides, delay of cellular division and induction of hypoxia in the tissues. Radioprotective agents have been divided into four major groups: the thiol compounds, other sulfur compounds, pharmacological agents (anesthetic drugs, analgesics, tranquilizers, etc.) and other radioprotective agents (WR-1065, WR-2721, vitamins C and E, glutathione, etc.). Several studies revealed the radioprotective action of Apis mellifera honeybee venom as well as that of its components mellitin and histamine. Radioprotective activity of bee venom involves mainly the stimulation of the hematopoietic system. In addition, release of histamine and reduction in oxygen tension also contribute to the radioprotective action of bee venom. (author)

  13. Radioprotection: mechanism and radioprotective agents including honeybee venom

    Energy Technology Data Exchange (ETDEWEB)

    Varanda, E.A.; Tavares, D.C. [UNESP, Araraquara, SP (Brazil). Escola de Ciencias Farmaceuticas. Dept. de Ciencias Biologicas

    1998-07-01

    Since 1949, a great deal of research has been carried on the radioprotective action of chemical substances. These substances have shown to reduce mortality when administered to animals prior to exposure to a lethal dose of radiation. This fact is of considerable importance since it permits reduction of radiation-induced damage and provides prophylactic treatment for the damaging effects produced by radiotherapy. The following radioprotection mechanisms were proposed: free radical scavenger, repair by hydrogen donation to target molecules formation of mixed disulfides, delay of cellular division and induction of hypoxia in the tissues. Radioprotective agents have been divided into four major groups: the thiol compounds, other sulfur compounds, pharmacological agents (anesthetic drugs, analgesics, tranquilizers, etc.) and other radioprotective agents (WR-1065, WR-2721, vitamins C and E, glutathione, etc.). Several studies revealed the radioprotective action of Apis mellifera honeybee venom as well as that of its components mellitin and histamine. Radioprotective activity of bee venom involves mainly the stimulation of the hematopoietic system. In addition, release of histamine and reduction in oxygen tension also contribute to the radioprotective action of bee venom. (author)

  14. Mankind, radiations and radioprotection

    International Nuclear Information System (INIS)

    After a brief recall of the historic knowledge on natural radioactivity, of the first developments of nuclear medicine and of the emergence of a necessary regulation of the use of these radiations, the author first proposes an overview of the relationship between radioactivity and exposure: sources of natural irradiation, sources of natural origin but modified by technology (medical exposure, professional exposure). Then, the author recalls the origin of radioprotection rules: the International Commission on Radiation Units and Measurements (ICRU), the International Commission on Radiological Protection (ICRP), the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). He addresses the notion of dose with its different types: absorbed dose, equivalent dose, effective dose, specific case of internal exposure with the notion of engaged dose. He gives an overview of the effects of ionizing radiations: deterministic effects, global external irradiation, partial irradiations, and stochastic effects. The next part addresses the radiological protection system: scope of application, the three principles (justification, optimisation, and limitation), and dose limitations. Some matters of debate are reviewed: consequences of accidents of reactors, of Chernobyl and Fukushima (mortality by acute radiation syndrome, thyroid cancers, other cancers, leukaemia, non cancerous diseases, projections and conclusions after the Chernobyl accident), the notions of collective dose and of radio-toxicity, radio-induced cancers and genetic predisposition

  15. Proceedings of the 9. meeting of radioprotection skill persons

    International Nuclear Information System (INIS)

    During these 2 days of conference, an update was given regarding: the recent or coming soon French regulatory texts, the advances of 2 softwares used by the French Institute of Radiation Protection and Nuclear Safety (IRSN) for national inventory of radiation sources and for the monitoring of personnel dosimetry, the reports in progress of working groups (sources, dosimetry), the progress and transposition of the Euratom 2013/59 directive which directly concerns the radioprotection skill persons and which will be enforced in member states by February 6, 2018. Practical aspects and experience feedbacks have been presented by participants as well. This document brings together the available presentations (slides) together with their corresponding abstracts (in French) and dealing with: 1 - Current regulations in radioprotection of workers exposed to ionizing radiations (T. Lahaye); 2 - Changes in the classified facilities nomenclature (J. Vallet); 3 - Transposition works for the 2013/59/Euratom directive dealing with basic radioprotection standards (N. Saad, J. Vallet, T. Lahaye); 4 - 50 years anniversary of the French Society of Radiation Protection (SFRP); 5 - Working group on personnel radiological monitoring: progress of works (P. Barbey); 6 - What about the internal exposure contribution to the efficient dose in nuclear medicine? (S. Prevot); 7 - Environmental monitoring of workplaces subject to tritium exposure risk (L. Tenailleau); 8 - Radon: example of radioprotection skill persons involvement in corrective actions, the case of the university technology institute of Vire - Calvados (G. Pigree); 9 - Unique document, prevention plan: a continuous risk assessment approach (M. Hery); 10 - 2014 evolutions of the SISERI System - first experience feedback (P. Scanff); 11 - Evolution of registration rules for radioactive sources in the national inventory using the SIGIS Internet platform (C. Reuter); 12 - Radioprotection skill person networks, radioprotection actors

  16. Argentine National Pharmacopoeia (Argentine Codex Medicamentarius). 6. ed., suppl. 1982.

    International Nuclear Information System (INIS)

    Standards of mandatory application, established by Law No. 22729 of February, 1983, on radiopharmaceuticals and radiosterilization of products for medical use, issued as a supplement to the text of the Argentine National Pharmacopoeia. In particular, the general characteristics, identification and purity tests, radioactivity valuation, top date of utilization, and form of conservation of different radiopharmaceuticals are described. (C.A.K.)

  17. Study in vitro of origin radioprotective food the radioprotective effect in vitro of food borne

    International Nuclear Information System (INIS)

    Study in vitro of origin radioprotective food the radioprotective effect in vitro of food borne substances studied is a first step in developing effective radioprotectors that can prevent radiation damage to healthy tissue., cannot forget that these studies must be accompanied by in vitro studies of toxicity and bioavailability to profile designing radioprotective substance.

  18. A review of radioprotective plants

    Directory of Open Access Journals (Sweden)

    Prasan R Bhandari

    2013-01-01

    Full Text Available Radioprotective compounds have been used to diminish morbidity or mortality produced by ionizing irradiation. Initial developments of such agents concentrated on thiol synthetic compounds, like amifostine. This agent decreased mortality; however, there were difficulties in administering aminothiols that led to adverse effects. Unfortunately, no ideal, safe synthetic radioprotectors are available to date; hence, the exploration for other sources, including plants, has been ongoing for several decades. A methodical screening strategy can offer leads to isolating prospective novel candidate drugs from plant sources, for alleviation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are extensively used in traditional systems of medicine, and which have rendered noteworthy radioprotection in both in vitro and in vivo model systems.

  19. Radioprotective activity of folic acid

    International Nuclear Information System (INIS)

    The radioprotective activity of folic acid has been studied using rat liver mitochondria membrane, protein and superoxide dismutase (SOD) as well as pBR 322 plasmid DNA as the model in vitro systems. The vitamin could effectively prevent the γ-ray induced lipid peroxidation as assessed by measuring thiobarbituric acid reactive substrates and protein carbonyl formation effectively. It also could also prevent radiation-induced damage of mitochondrial SOD and restore its level to normalcy Likewise; it prevented radiation-induced DNA strand breaks in a concentration dependent manner. The radioprotective activity could be attributed to its ability to scavenge the hydroxyl and superoxide radicals wherein its pseudo-phenolic moiety and C-9 methylene group play the key role. Radioprotective activity of a polysaccharide preparation from the Indian medicinal plant, Tinospora cordifolia Miers has been established using Saccharomyces cerevisiae X2180 strain as the in vivo test model. The entire activity could be attributed to the radical scavenging capacity of the preparation, as it did not enhance the expression of the protective enzymes, catalase and superoxide dismutase in the yeast cells. (author)

  20. Contemporary Argentine Cinema during Neoliberalism

    Science.gov (United States)

    Rocha, Carolina

    2009-01-01

    In this article I analyze contemporary Argentine cinematic production assessing the impact of Law 24,377 that was implemented in 1995 and that provided much-needed funds for national productions. By looking at film production and consumption, the emergence of young filmmakers and the performance of both commercial films and those belonging to the…

  1. Perspectives on Argentine Migration to Spain: Oral, Journal and Film Sources

    Directory of Open Access Journals (Sweden)

    Susana Schmidt

    2010-03-01

    Full Text Available This contribution takes up our doctoral research –Argentine migrationto Spain- to share some theoretical-methodological considerations.We refer to the conceptualization of "transnational social spaces," an approach that allows us to consider migration in its double dimension origin/destination and is particularly useful to thing the relationship between migration and creation of social and cultural ties in the Hispano-Argentine or Argentine-Spanish space. Similarly, the transnational spaces approach allows to put in dialog diverse social groups involved in the phenomenon: the migrants themselves, whose life stories are analysed by using oral sources; the society of origin and the host society, analysing collective image through journal sources; the filmmakers, whose migration stories we discussmigration through various fiction films; and, of course, historians and other social scientists who study these migrations.

  2. Tinned fish with radioprotective ingredients

    International Nuclear Information System (INIS)

    A survey of food ingredients with pronounced radioprotective properties is made. The protective effect of fish proteins and some vegetable oils is mentioned. As suitable additives to tinned fish during the manufacturing process the β carotene, anthocyans and apple pectin are pointed out. β-carotene possesses the ability to absorb radiations. It can be added either as a pure crystalline substance or dissolved in the vegetable oil. Anthocyans have an antimutagen effect due to their ability to inhibit free radical reactions. Some vegetable polyphenols can be added with wine. The Bulgarian anthocyan concentrate Enobagrin (made by extraction of marc and wine) is also proposed. A combination of Enobagrin, β-tocopherol and pyracetam decreases the postradiation hypoplasia. Special attention is paid to the importance of the pectin in intoxication with heavy radioactive metals. It is thought that the pectin forms unsoluble complex compounds with Fe, Zn, Cd, Co, Pb, Hg, Mn, Cr. The binding energy depends on the available carboxylic groups. Some experiments showing the interaction of the pectin with 90Sr are mentioned. In the tinned fish the pectin can be introduced with tomato paste. Vegetables rich in pectin and carotene - carrots and tomato concentrate - can be added as well. Proposed enriched tinned fish can be used as a preventive radioprotective food under conditions of increased radiation risk. 19 refs

  3. Effects of radioprotective agents on mammal cella

    International Nuclear Information System (INIS)

    The effects of aminothiols and thiophosphates on cultures of B14 Chinese Hamster cells wee investigated. 30 min before irradiation, the cells were covered with a solution of the radioprotective agent. After irradiation, this solution was removed and substituted by culture medium. The radioprotective effect increases with increasing cystamine concentrations. With a cystamine concentration of 60 mM, a dose reduction factor of 3 was achieved. Further investigations showed that already after 2 min of incubation, the radioprotective effect in the same as after 60 min. (orig./MG)

  4. Schooling and Governance: Pedagogical Knowledge and Bureaucratic Expertise in the Genesis of the Argentine Educational System

    Science.gov (United States)

    Southwell, Myriam

    2013-01-01

    The consolidation of the Argentine Federal Government by the 1870s aimed to modernise local society, establish state institutions and reach political stabilisation. Building a modern schooling system articulated both utopia and bureaucracy by establishing the use of knowledge as an instrument of social intervention, vindicating and legitimising…

  5. Control de la glucemia en el postoperatorio de cirugía cardíaca: Informe del Consejo de Emergencias de la Sociedad Argentina de Cardiología Blood glucose control during cardiac surgery: Report of the Emergency Council of the Argentine Society of Cardiology

    Directory of Open Access Journals (Sweden)

    Mariano N. Benzadón

    2012-02-01

    Full Text Available La hiperglucemia en el postoperatorio de cirugía cardÍaca es un hallazgo frecuente asociado a peor evolución, que afecta tanto a diabéticos como no diabéticos. A pesar de las múltiples publicaciones disponibles, aún no existe un abordaje universalmente aceptado a este problema. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir cómo debe ser el manejo de la glucemia en el paciente crítico cardiovascular. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia en el postoperatorio de cirugía cardíaca.Hyperglycemia after cardiac surgery is a common finding associated with the worse outcomes affecting both diabetic and non diabetic patients. Despite the large number of publications available, there is no universally accepted approach to this problem. In an initiative of the Emergency Council of the Argentine Society of Cardiology, local experts gathered to discuss the management of hyperglycemia after adult cardiac surgery. The main objective of the present paper is to summarize the current state of knowledge regarding glycemic control in postoperative cardiac surgery.

  6. Radioprotection of the patient in nuclear medicine

    International Nuclear Information System (INIS)

    The following topics are developed: concepts on radioprotection; stochastic and deterministic effects; the prenatal irradiation; different types of radiation exposition (medical, occupational and public irradiation); and the justification of the levels of radiation

  7. The ViewPoint radioprotection supervision workstation; Poste de supervision radioprotection viewpoint

    Energy Technology Data Exchange (ETDEWEB)

    Gaultier, E. [APVL Ingenierie- 6, bd Nobel - Equatop La Rabelais - 37540 Saint Cyr sur Loire (France)

    2009-07-01

    The author briefly presents the ViewPoint supervision global solution which incorporates audio and video advanced technologies to manage radioprotection operational measurements. Data can be transmitted by-wire or wireless. It can integrate a large number of radioprotection measurement instruments, such as a belt for the monitoring of physiological parameters (body temperature, breathing rhythm, body posture)

  8. Nucleoelectric energy in the Argentine Republic

    International Nuclear Information System (INIS)

    This text intends to reflect a coherent and sustained management in the Argentine nucleoelectrical policy. Through individual thematic unities connected between them, the basic structure consists of three principal parts. The first part introduces a broad panorama of atomic energy in the world, in the international treaties and organizations. Also the technical, economic and political aspects which had influence in the Argentine nuclear policies, particularly in the electrical production with nuclear power plants, are considered in this part. The second part describes the historical sequence of the principal achievements of the Argentine National Atomic Energy Commission (CNEA) in the nuclear industry. A mention of particular criteria adopted in each situation and the intention and motivations that guide the decisions are also considered. Finally, an actual balance of the nucleoelectrical technology situation in Argentine and in the world is presented. (Author)

  9. Biotic and abiotic controls of argentine ant invasion success at local and landscape scales

    Science.gov (United States)

    Menke, S.B.; Fisher, R.N.; Jetz, W.; Holway, D.A.

    2007-01-01

    Although the ecological success of introduced species hinges on biotic interactions and physical conditions, few experimental studies - especially on animals - have simultaneously investigated the relative importance of both types of factors. The lack of such research may stem from the common assumption that native and introduced species exhibit similar environmental tolerances. Here we combine experimental and spatial modeling approaches (1) to determine the relative importance of biotic and abiotic controls of Argentine ant (Linepithema humile) invasion success, (2) to examine how the importance of these factors changes with spatial scale in southern California (USA), and (3) to assess how Argentine ants differ from native ants in their environmental tolerances. A factorial field experiment that combined native ant removal with irrigation revealed that Argentine ants failed to invade any dry plots (even those lacking native ants) but readily invaded all moist plots. Native ants slowed the spread of Argentine ants into irrigated plots but did not prevent invasion. In areas without Argentine ants, native ant species showed variable responses to irrigation. At the landscape scale, Argentine ant occurrence was positively correlated with minimum winter temperature (but not precipitation), whereas native ant diversity increased with precipitation and was negatively correlated with minimum winter temperature. These results are of interest for several reasons. First, they demonstrate that fine-scale differences in the physical environment can eclipse biotic resistance from native competitors in determining community susceptibility to invasion. Second, our results illustrate surprising complexities with respect to how the abiotic factors limiting invasion can change with spatial scale, and third, how native and invasive species can differ in their responses to the physical environment. Idiosyncratic and scale-dependent processes complicate attempts to forecast where

  10. Biological radiation effects and radioprotection standards

    International Nuclear Information System (INIS)

    In this report, after recalling the mode of action of ionizing radiations, the notions of dose, dose equivalents and the values of natural irradiation, the author describes the biological radiation effects. Then he presents the ICRP recommendations and their applications to the french radioprotection system

  11. Review: radioprotection applied in Nuclear Medicine

    International Nuclear Information System (INIS)

    The aim of this paper is to evaluate the potential causes of exposure to ionizing radiation in a nuclear medicine facility, identifying the causes of common errors in the clinical routine, how to avoid these errors and study good radioprotection practices based on the national law and international documents. (author)

  12. Proceedings of the 6. conference days on radioprotection optimization in the nuclear, industrial and medical domains

    International Nuclear Information System (INIS)

    This 6. ALARA conference was jointly organised by the French Society of Radiation Protection (SFRP) and several professional associations (ABR, AFPPE, ARRAD, ATSR, RAMIP, SFPM, SFR). The conference was the occasion to review all aspects relative to the issues of radioprotection optimization and to its implementation to workers, patients and the public in the nuclear, industrial and medical domains. A particular attention must be given to the application of the ALARA principle in all sectors relevant to radioprotection, especially in a context characterized by: big dismantling works under preparation in the French nuclear park, an increased use of X-radiation in the medical domain - involving both patients and medical personnel, new knowledge concerning the health effects of ionizing radiations, and an evolution of European and international radioprotection safety standards. All these aspects were discussed during these conference days. This document brings together the available presentations (slides) together with their corresponding abstracts (in French) and dealing with: 1 - Review of the evolution of workers/patients exposure in France and comparison with international data (E. Vial); 2 - Status of low dose epidemiology (M.O. Bernier); 3 - Radioprotection optimization method at the MELOX plant (A. De Vita); 4 - Elaboration method for the annual dosimetric objective of the French nuclear park (C. Pignot); 5 - Optimisation principle in the new EURATOM Directive (N. Saad); 6 - Integrated management of radiological and non-radiological risks: the inevitable challenge (P. Deboodt); 7 - Radiological and conventional risks: the French Atomic Energy Commission (CEA) integrated approach (S. Faure); 8 - EVEREST (Evolving towards an entry into controlled areas in street clothes, M. Alvarez); 9 - Example of multi-risk management in the medical domain (C. Tourneux); 10 - Radioprotection optimisation in the research domain (P. Barbey); 11 - Child scanning dosimetry

  13. Determination of the radioprotective activity of certain analogs of imipramine

    International Nuclear Information System (INIS)

    Investigation of some derivatives of azepine, structurally related to imipramine in view of their radioprotective activity towards γ-radiation. Among them, three compounds displayed significant activity

  14. The worldwide expansion of the Argentine ant

    DEFF Research Database (Denmark)

    Vogel, Valerie; Pedersen, Jes Søe; Giraud, Tatiana;

    2010-01-01

    ) and secondary introductions (from sites with established invasive supercolonies) were important in the global expansion of the Argentine ant. In combination with the similar social organization of colonies in the native and introduced range, this indicates that invasiveness did not evolve recently as a unique...

  15. Radioprotective potential of mint: A brief review

    Directory of Open Access Journals (Sweden)

    Baliga Manjeshwar

    2010-01-01

    Full Text Available Radiation is an important modality in cancer treatment and estimates are that between one third and one half of all patients will require ionizing irradiation therapy during some point in their clinical management. However, the radiation-induced damage to the normal tissues restricts the therapeutic doses of radiation that can be delivered to tumors and thereby limits the effectiveness of the treatment. The use of chemical compounds (radioprotectors represents an obvious strategy to improve the therapeutic index in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical application owing to their inherent toxicity and high cost. These observations necessitated a search for alternative agents that are less toxic and highly effective. Studies in the recent past have shown that some medicinal plants possess radioprotective effects. Two species of the commonly used aromatic herb mint, Mentha piperita and M. arvensis protected mice against the γ-radiation-induced sickness and mortality. Detail investigations have also shown that the aqueous extract of M. piperita protected the vital radiosensitive organs: the testis, gastrointestinal and hemopoetic systems in mice. The radioprotective effects are possibly due to free radical scavenging, antioxidant, metal chelating, anti-inflammatory, antimutagenic, and enhancement of the DNA repair processes. This review for the first time summarizes the observations and elucidates the possible mechanisms responsible for the beneficial effects. The lacunae in the existing knowledge and directions for future research are also addressed.

  16. Radioprotective Agents: Strategies and Translational Advances.

    Science.gov (United States)

    Kamran, Mohammad Zahid; Ranjan, Atul; Kaur, Navrinder; Sur, Souvik; Tandon, Vibha

    2016-04-01

    Radioprotectors are agents required to protect biological system exposed to radiation, either naturally or through radiation leakage, and they protect normal cells from radiation injury in cancer patients undergoing radiotherapy. It is imperative to study radioprotectors and their mechanism of action comprehensively, looking at their potential therapeutic applications. This review intimately chronicles the rich intellectual, pharmacological story of natural and synthetic radioprotectors. A continuous effort is going on by researchers to develop clinically promising radioprotective agents. In this article, for the first time we have discussed the impact of radioprotectors on different signaling pathways in cells, which will create a basis for scientific community working in this area to develop novel molecules with better therapeutic efficacy. The bright future of exceptionally noncytotoxic derivatives of bisbenzimidazoles is also described as radiomodulators. Amifostine, an effective radioprotectant, has been approved by the FDA for limited clinical use. However, due to its adverse side effects, it is not routinely used clinically. Recently, CBLB502 and several analog of a peptide are under clinical trial and showed high success against radiotherapy in cancer. This article reviews the different types of radioprotective agents with emphasis on the strategies for the development of novel radioprotectors for drug development. In addition, direction for future strategies relevant to the development of radioprotectors is also addressed. PMID:26807693

  17. Study of radioprotective effect of the resveratrol

    International Nuclear Information System (INIS)

    Resveratrol (3,4,5 trihydroxystilbene), a phenolic phytoalexin occurring naturally in a wide variety of plants, such as grapevines, in response to injury as fungal infections and exposure to ultraviolet light. In the wines this compound is present at high levels and is considered one of the highest antioxidant constituents. This high capacity to scavenge the free radicals generated by several biologic processes by resveratrol can provide a prevention of human cardiovascular diseases and several types of cancer. The main objective of this study was to determine the in vitro radioprotective effect of resveratrol in cell culture with the aid of the tests of cytotoxicity of resveratrol (IC50%) and lethal dose 50% of gamma radiation (LD50). Studies of the level of resveratrol toxicity, found by cytotoxicity test performed by neutral red uptake assay, and lethal dose 50% (LD50) of gamma radiation from source of Cobalt-60 (Co-60) was performed in cell culture NCTC Clone 929 from ATCC. The IC50% of resveratrol was about 50 M/L. The DL50 of gamma radiation showed a value of about 354 Gy. On the basis of these biological results, it was performed studies of radioprotective effect of resveratrol on the same experimental conditions, verifying that the resveratrol in concentrations between 12.5 M/L and 25 M/L showed a more pronounced radioprotective effect. (author)

  18. Natural product as potential of radioprotective agents

    Directory of Open Access Journals (Sweden)

    S.J. Hosseinimehr, Ph.D.

    2007-01-01

    Full Text Available AbstractSince exposure to irradiation in radiotherapy or unwanted radiation, induces side effects to health, it is important to makear effort to protect humans against side effects induced by irradiation. In these cases, radioprotective drugs could be used to reduce or delay the side effects and the mortality induced by irradiation. Although, thiol compounds were early compounds in these categories, administration of these agents have induced serious side effects and is limited to use clinically. The search for less-toxic radiation protectors has spurred interest in the development of natural products. Natural products have mainly antioxidant and immunostimulant activity. Cytokines and androsetendiol have immunomudulatory effects in the prevention of mortality induced by gamma irradiation in animal model. Many studies have showed herbal medicine has good radioprotective effects. Flavonoids are one of the main chemical compositions in herbal medicine with antioxidant activity. Although, these natural products had low efficacy in comparison to thiol compounds, they have low toxicity. This review focused on recent radioprotective agents with natural origin that have more potential effects.

  19. Radioprotection rayonnements, dosimétrie, protection

    CERN Document Server

    Marey, Gérard

    2014-01-01

    Pour tous les travailleurs du nucléaire comme pour les étudiants des licences professionnelles et des BTS Environnement nucléaire et BTS radioprotection, l'ouvrage rassemble de façon progressive, claire et précise toutes les informations scientifiques et pratiques qui leur sont indispensables. Une première partie résume les données de base relatives à la structure de la matière, la stabilité des noyaux, les différents rayonnements, leur énergie et la décroissance radioactive. La deuxième partie constitue une approche progressive de la radioprotection s'appuyant sur l'influence des rayonnement sur la matière pour définir les notions de dose et aborder le dimensionnement des protections biologiques et des éléments de ventilation. Enfin, la dernière partie traite de la mise en oeuvre pratique de la radioprotection sur le terrain et de la gestion des déchets nucléaires en application de la technologie actuelle, de la réglementation et des directives imposées par l'exploitant qu'est EDF. De...

  20. Participation of women in neurochemistry societies.

    Science.gov (United States)

    Lees, Marjorie B

    2002-11-01

    Women have made important scientific contributions to the field of neurochemistry, and they have also been leaders in neurochemical societies throughout the world. Here I discuss women's involvement and leadership in six neurochemistry societies: American Society for Neurochemistry, Argentine Society for Neurochemistry, International Society for Neurochemistry, European Society for Neurochemistry, Japanese Society for Neurochemistry, and Asian-Pacific Society for Neurochemistry. The number of women who have been active in these societies and the level of their activity vary considerably. Neurochemical societies in the Western hemisphere, i.e., the American and the Argentine Society for Neurochemistry, have much greater numbers of women who have held office, been on council, or engaged in other leadership activities than in the rest of the world. The limited participation of women in the Japanese Neurochemistry Society relates to Japanese cultural views and was not unexpected. However, the relatively few women leaders in the International Society for Neurochemistry was a surprise. The European Society had a somewhat better record of female participation than did the International Society. The reasons for these differences are partly cultural, but factors related to when each society was formed, how it is organized, and how elections are structured undoubtedly play a role. Further analysis of these observations would be of interest from a sociological and a women's studies point of view.

  1. Computerized examination system on radioprotection knowledge

    International Nuclear Information System (INIS)

    The aim of this paper is to present the recognition system of the education and training in the field of radioprotection based on the examination system and the software solutions adopted by the regulatory authority in Romania. The Romanian Radiation Protection system is in place since 1950, when the first nuclear research reactor was built and activities involving radioactive sources started to be developed, and several developing phases were passed through. Linked to the Romanian Radiation Protection system an Education, Training and Recognition system was developed. The recognition of the competencies achieved by the personnel in the framework of the education and training system consists in obtaining a work permit. It is mandatory at least for the radiological safety officers to posses a work permit granted by the Romanian Regulatory Body (CNCAN) based on an examination of the radioprotection knowledge. The examination consists in solving a questionnaire on radioprotection and legislation issues. Each participant receives a questionnaire with 60 questions and has to solve it in a time limit of one hour. In 2007 the examination system has been improved by authors who designed a software and a database which contains all the questions and answers with related explanations. For each examination session the software generates randomly for each participant the examination questionnaire. More than 2000 questions and answers from the database are published on the web site of CNCAN for different fields of ionizing radiation applications. Moreover the generated questions and participant's answers are registered in order to perform the further analysis and review. The result is an objective and transparent examination system which encourages the continuous training and retraining. (author)

  2. Interventional techniques in medicine and radioprotection

    International Nuclear Information System (INIS)

    This document gathers the slides of the available presentations given during this conference day. Nineteen presentations are assembled in the document and deal with: 1 - Interventional radiology: why is it developing? (M. Sapoval); 2 - exposure particularities in interventional radiology (O. Bar); 3 - doses received by organs in interventional cardiology (C. Maccia); 4 - Patients exposure: description of cumulated exposure of patients treated in interventional cardiology (M.O. Bernier); 5 - 2004 inquiry to dermatologists about post-interventional radiology radio-dermatitis (P. Pirard); 6 - exposure and risks to operators (S. Jacob); 7 - dosimetric evaluation techniques and results about interventional imaging operators' extremities (L. Donadille and F. Merat); 8 - bibliographic study of doses received by operators with non-protected organs (B. Aubert); 9 - ORAMED European project: optimization of operational dosimeter uses in interventional radiology (I. Clairand); 10 - reference levels and dosimetric evaluation of patients (C. Maccia); 11 - optimization in coronary angioplasty (J.G. Mozziconacci, A.M. Brot and V. Jarrige); 12 - dosimetry in medical over-exposure situation (C. Huet); 13 - significant radioprotection events in interventional radiology declared to the Nuclear Safety Authority (ASN) - status and experience feedback (C. Marchal); 14 - interventional radiology and unwanted effects (M. Benderitter); 15 - global analyses and new exposure indicators in human epidermis cells (M. Martin); 16 - radioprotection regulations and training (O. Bar); 17 - zoning and workplace analysis in interventional cardiology (J.P. Degrange); 18 - guide of good clinical practices: example of interventional cardiology (B. Livarek); 19 - how to encourage the radioprotection optimization in interventional radiology: the ASN's point of view (P. Menechal). (J.S.)

  3. Argentine hemorrhagic fever: a primate model.

    Science.gov (United States)

    Weissenbacher, M C; Calello, M A; Colillas, O J; Rondinone, S N; Frigerio, M J

    1979-01-01

    Experimental Junin virus infection of a New World primate, Callithrix jacchus, was evaluated. The virus produced anorexia, loss of weight, thrombocytopenia, leukopenia, and hemorrhagic and neurological symptoms and terminated in death. Virus was recovered from urine, blood samples and all tissues taken at autopsy. These preliminary observations show that several aspects of the experimental disease in C. jacchus are quite similar to severe natural Argentine hemorrhagic fever of man.

  4. Note from the radioprotection group's shipping service

    CERN Multimedia

    2006-01-01

    Le service SHIPPING du groupe de radioprotection souhaite vous rappeler qu'avant toute expédition de matériel susceptible d'être radioactif, une demande de transport doit être établie par EDH en cochant la case appropriée (danger radioactif). Merci de bien vouloir prendre note des informations figurant dans le site Web: http://cern.ch/service-rp-shipping Toute demande non conforme ne sera pas prise en compte. Radioactive Shipping Service http://cern.ch/service-rp-shippingTél: 73171Fax: 69200

  5. Colorado Basin Structure and Rifting, Argentine passive margin

    Science.gov (United States)

    Autin, Julia; Scheck-Wenderoth, Magdalena; Loegering, Markus; Anka, Zahie; Vallejo, Eduardo; Rodriguez, Jorge; Marchal, Denis; Reichert, Christian; di Primio, Rolando

    2010-05-01

    partly supports this hypothesis and shows two main directions of faulting: margin-parallel faults (~N30°) and rift-parallel faults (~N125°). A specific distribution of the two fault sets is observed: margin-parallel faults are restrained to the most distal part of the margin. Starting with a 3D structural model of the basin fill based on seismic and well data the deeper structure of the crust beneath the Colorado Basin can be evaluate using isostatic and thermal modelling. Franke, D., et al. (2002), Deep Crustal Structure Of The Argentine Continental Margin From Seismic Wide-Angle And Multichannel Reflection Seismic Data, paper presented at AAPG Hedberg Conference "Hydrocarbon Habitat of Volcanic Rifted Passive Margins", Stavanger, Norway Franke, D., et al. (2006), Crustal structure across the Colorado Basin, offshore Argentina Geophysical Journal International 165, 850-864. Gladczenko, T. P., et al. (1997), South Atlantic volcanic margins Journal of the Geological Society, London 154, 465-470. Hinz, K., et al. (1999), The Argentine continental margin north of 48°S: sedimentary successions, volcanic activity during breakup Marine and Petroleum Geology 16(1-25). Hirsch, K. K., et al. (2009), Tectonic subsidence history and thermal evolution of the Orange Basin, Marine and Petroleum Geology, in press, doi:10.1016/j.marpetgeo.2009.1006.1009

  6. Radioprotection: Gelam Honey And Other Potential Natural Sources As Radioprotectant Agent

    International Nuclear Information System (INIS)

    The application of antioxidant compounds has been studied since the early days of nuclear era, due to the high possibility of overexposure among individuals working in radiation facilities. Ionising radiations can trigger the formation of free radicals which induces biological damage even at a very low dose. It can damage DNA molecules via two mechanisms, either directly or indirectly. Therefore, radioprotectant must have the characteristic of a free radical scavenger to prevent those damages. In this study, the effect of gamma irradiation-induced DNA damage and cellular response was determined by DNA damage pathway. Gelam honey was chosen to determine its radioprotective efficacy when normal human diploid fibroblasts (HDFs) were exposed to gamma-rays. HDFs were treated with Gelam Honey at pre-, during- and post-irradiation at 1 Gray dose. Through this study, gamma-irradiation modulated the cell defence system which involved expression of gene/protein of DNA damage detection, subsequently lead to cell cycle arrest and apoptosis induction. Conversely, HDFs pre-treated with Gelam honey maintained the cell proliferation as shown by the decrease in DNA damage and increase in cell survival rate. These mechanisms may be used as one of the guidelines for radioprotection study with other natural resources such as beta-glucan extract from mushrooms. (author)

  7. Analysis of Minocycline as a Radioprotectant

    Science.gov (United States)

    Mehrotra, Shalini

    Exposure to radiation is increasing in a variety of settings including space exploration, diagnostic medical procedures and radiotherapy. Cells of the hematopoietic system, such as white blood cells (WBC), are especially sensitive to radiation and their decline can result in Acute Radiation Syndrome (ARS). Radiotherapy is often used for cancers of the central nervous system (CNS), but includes the risk for normal tissue damage, often leading to cognitive impairment. The literature suggests that tetracyclines can be radioprotectors of the hematopoietic system with potential utility in radiation emergencies and anticancer radiotherapy. Minocycline, a semisynthetic tetracycline derivative, has anti-inflammatory, free radical scavenging, anti-apoptotic and anti-angiogenic properties with exceptional penetration into the CNS. These qualities make it a viable candidate for use in combination with radiotherapy for CNS tumors as a normal tissue radioprotectant and for hematopoietoc recovery following whole-body irradiation. This study was undertaken to determine the potential of minocycline as a radioprotective agent of the hematopoietic system and CNS in response to whole-body irradiation with 1, 2 and 3 Gy (γ-rays). C57BL/6 mice were injected with minocycline, 5 times beginning immediately before irradiation. Spleen, blood and brain were collected on days 4 and 32 post-irradiation. WBC and other cell populations were determined in the blood and spleen while cytokines were quantified in CD3-activated splenocytes and homogenized brain supernatants. We also evaluated the impact of minocycline on DNA synthesis and viability of human glioblastoma cells versus astrocytes and microglia. Minocycline increased counts and percentages of splenic macrophages, granulocytes, natural killer (NK), T and CD8 + T cells on day 4 and B cells on day 32. Minocycline up-regulated interleukin-1α (IL-1α)which is radioprotective, as well as granulocyte-macrophage colony stimulating factor (GM

  8. The Argentine-Brazilian fast reactor programme

    International Nuclear Information System (INIS)

    This paper summarizes the Argentine-Brazilian Fast Reactor Programme and gives reasons for the decision of a binational venture. The work carried out by both countries is described, showing how they complement each other, with the corresponding saving of resources. The main objectives of the Programme and tentative schedules in three progressing integrating stages are given and the present nuclear know-how in each country is identified as a good starting point. The paper also gives some details regarding the economical and human resources involved. (author). 1 graph

  9. Radioprotection in the medical applications of the ionizing radiations

    International Nuclear Information System (INIS)

    This publication presents information about of the radiological safety in the medical application of the ionizing radiation compiled in 11 chapter and 1 annex. The first four chapters are principally dedicated to technical uses in radioprotection, the external and internal irradiation and the biological radiation effects. The radioprotection principles, the individual monitoring techniques, and the radioprotection systems are developed afterwards in the followings three chapters. The second half of the document is dedicated entirely to the medical practices using ionizing radiations, specially to the radioprotection aspects in radiodiagnosis, nuclear medicine and radiotherapy. The final chapter is dedicated to radiological accidents happened worldwide in the field of the medical applications of the ionizing radiations. The annex, about of the regulatory area, established a set of standards, laws, decrees and other force regulations in radiological safety, related in radiodiagnosis, nuclear medicine and radiotherapy

  10. Evaluation of the radioprotective efficacy of rifaximin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Won Woo; Kim, Mi Sook; Jeong, Jae Hoon; Kim, Hee Jong [Dept. of Radiation Treatment Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2014-04-15

    Radiation exposure causes severe intestinal damage, and intestinal injury has been shown to plays a pivotal role in survival. The non-systemic antibiotic, rifaximin, is used in the treatment of traveler's diarrhea due to bacterial enteropathogens and has an anti-biotic and an anti-inflammatory effect with low gastrointestinal absorption of < 0.4%. Rifaximin also has been used for treatment of irritable bowel syndrome, small bowel bacterial overgrowth, pouchitis. Jahraus et al. reported that rifaximin diminishes neutropenia following potentially lethalmwhole-body radiation. The purpose of this study was to evaluate the radioprotective effect of rifaximin on ionizing radiation-induced intestinal injury. Rifaximin showed increased survival rate as well as decreased weight loss between pre treatment and post treatment. Fortunately rifaximin seems to involveincreased number of crypt cells and length of villus. These findings suggest that rifaximin can be a strategy by protecting intestinal injury.

  11. Radio-protective role of antioxidant agents

    Directory of Open Access Journals (Sweden)

    Alireza Shirazi

    2012-10-01

    Full Text Available Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

  12. Molecular study of DNA radioprotection by thiols

    Energy Technology Data Exchange (ETDEWEB)

    Savoye, C.; Charlier, M.; Spotheim-Maurizot, M. [Centre National de la Recherche Scientifique (CNRS), 45 - Orleans-la-Source (France); Swenberg, C. [ACRD, Armed Forces Radiobiology Research Institute, Bethesda (United States); Sabattier, R. [Centre Hospitalier Regional d`Orleans, 45 (France)

    1997-03-01

    Polyamines (PA) are natural components of mammalian cells, essential for growth processes. Since a decrease of the cellular level of PA increases the effect of radiotherapy on tumour cells, we have supposed that PA may act as DNA radioprotectors. The search of non-toxic agents that protect specifically normal cells led to the discovery of the agent WR-2721 used now in cancer cancer therapy under the name Ethyol (Amifostine) and of the agent WR-151327. Both have a chemical structure close to that of natural PA. The main radioprotective metabolites of these agents are the thiols WR>61065 and WR-151326. We have compared here here the protective effects of these thiols to those of another simpler thiol, the cysteamine, and of a related PA, the putrescine, on the number and location of fast neutrons-induced DNA strand breaks. (authors)

  13. Ninth Argentine congress on biology and nuclear medicine; fourth Southernmost sessions of ALASBIMN (Latin-American Association of Biology and Nuclear Medicine); first Spanish-Argentine congress on nuclear medicine; first Argentine sessions on nuclear cardiology

    International Nuclear Information System (INIS)

    This work deals with all the papers presented at the 9. Argentine congress on biology and nuclear medicine; IV Southernmost sessions of ALASBIMN; I Spanish-Argentine congress on nuclear medicine and I Sessions Argentine sessions on nuclear cardiology held in Buenos Aires, Argentina, from October 14 - 18, 1991

  14. The application of radioisotopes in the Argentine technology

    International Nuclear Information System (INIS)

    The different applications of radioisotopes: as sealed sources or tracers, as well as activation analysis have cast a new light on Argentine engineering and industry. The Argentine Atomic Energy Commission is carrying out an active plan for the developement and promotion of these techniques since the 60's. This report describes and analyzes the most outstanding applications, and brings up to date other previous papers on the same subject. It suggests some ideas for achieving a complete penetration of radioisotope techniques into Argentine technology. It also outlines some future perspectives, based on present statistical data. (author)

  15. Interventional techniques in medicine and radioprotection; Les techniques interventionnelles en medecine et radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Le Guen, B.; Bar, O.; Benderitter, M.; Bourguignon, M.; Chevillard, S.; Gauron, Ch.; Lallemand, J.; Lombard, J.; Maccia, C.; Sapoval, M.; Bernier, M.O.; Pirard, Ph.; Jacob, S.; Donadille, L.; Aubert, B.; Clairand, I.; Mozziconacci, J.G.; Brot, A.M.; Jarrige, V.; Huet, Ch.; Marchal, C.; Martin, M.; Bar, O.; Degrange, J.P.; Livarek, B.; Menechal, Ph.; Sapoval, M.; Pellerin, O.

    2009-07-01

    This document gathers the slides of the available presentations given during this conference day. Nineteen presentations are assembled in the document and deal with: 1 - Interventional radiology: why is it developing? (M. Sapoval); 2 - exposure particularities in interventional radiology (O. Bar); 3 - doses received by organs in interventional cardiology (C. Maccia); 4 - Patients exposure: description of cumulated exposure of patients treated in interventional cardiology (M.O. Bernier); 5 - 2004 inquiry to dermatologists about post-interventional radiology radio-dermatitis (P. Pirard); 6 - exposure and risks to operators (S. Jacob); 7 - dosimetric evaluation techniques and results about interventional imaging operators' extremities (L. Donadille and F. Merat); 8 - bibliographic study of doses received by operators with non-protected organs (B. Aubert); 9 - ORAMED European project: optimization of operational dosimeter uses in interventional radiology (I. Clairand); 10 - reference levels and dosimetric evaluation of patients (C. Maccia); 11 - optimization in coronary angioplasty (J.G. Mozziconacci, A.M. Brot and V. Jarrige); 12 - dosimetry in medical over-exposure situation (C. Huet); 13 - significant radioprotection events in interventional radiology declared to the Nuclear Safety Authority (ASN) - status and experience feedback (C. Marchal); 14 - interventional radiology and unwanted effects (M. Benderitter); 15 - global analyses and new exposure indicators in human epidermis cells (M. Martin); 16 - radioprotection regulations and training (O. Bar); 17 - zoning and workplace analysis in interventional cardiology (J.P. Degrange); 18 - guide of good clinical practices: example of interventional cardiology (B. Livarek); 19 - how to encourage the radioprotection optimization in interventional radiology: the ASN's point of view (P. Menechal). (J.S.)

  16. Argentine-Brazilian declaration on common nuclear policy

    International Nuclear Information System (INIS)

    The document reproduces the texts of the speeches made by the Presidents of Argentina and Brazil at Foz do Iguacu, Brazil, on 28 November 1990, at the signing of the Argentine-Brazilian Declaration on Common Nuclear Policy

  17. Exploration of Possible Astroblemes in the Argentine Puna

    Science.gov (United States)

    Acevedo, R. D.; Alonso, R.; Rocca, M.; Klajnik, K.; Tálamo, E.

    2014-09-01

    Potential three new astrobleme sites have been detected by remote sensors and checked in situ in Argentine Puna: an elevated plateau that it has remained stable and invariable across long geological periods.

  18. Framing crime: moral panic in Argentine newspapers

    Directory of Open Access Journals (Sweden)

    Natalia ARUGUETE

    2013-01-01

    Full Text Available Carolina Píparo was shot a few minutes after withdrawing cash from a bank branch. This case outraged the public opinion because she was eight months pregnant at the moment of the assault. She had to undergo a caesarean section and her baby only survived one week. Through an exploratory and inductive research we will analyze how the Argentine newspapers presented the case. We aim at elaborating a content analysis code book that can be validated in future similar researches on the subject. We apply the Framing theory in order to detect the frames used in the news coverage and to observe if they are compatible with the idea of «moral panic» proposed by Stanley Cohen.

  19. Pheromone disruption of Argentine ant trail integrity

    Science.gov (United States)

    Suckling, D.M.; Peck, R.W.; Manning, L.M.; Stringer, L.D.; Cappadonna, J.; El-Sayed, A. M.

    2008-01-01

    Disruption of Argentine ant trail following and reduced ability to forage (measured by bait location success) was achieved after presentation of an oversupply of trail pheromone, (Z)-9-hexadecenal. Experiments tested single pheromone point sources and dispersion of a formulation in small field plots. Ant walking behavior was recorded and digitized by using video tracking, before and after presentation of trail pheromone. Ants showed changes in three parameters within seconds of treatment: (1) Ants on trails normally showed a unimodal frequency distribution of walking track angles, but this pattern disappeared after presentation of the trail pheromone; (2) ants showed initial high trail integrity on a range of untreated substrates from painted walls to wooden or concrete floors, but this was significantly reduced following presentation of a point source of pheromone; (3) the number of ants in the pheromone-treated area increased over time, as recruitment apparently exceeded departures. To test trail disruption in small outdoor plots, the trail pheromone was formulated with carnuba wax-coated quartz laboratory sand (1 g quartz sand/0.2 g wax/1 mg pheromone). The pheromone formulation, with a half-life of 30 h, was applied by rotary spreader at four rates (0, 2.5, 7.5, and 25 mg pheromone/m2) to 1- and 4-m2 plots in Volcanoes National Park, Hawaii. Ant counts at bait cards in treated plots were significantly reduced compared to controls on the day of treatment, and there was a significant reduction in ant foraging for 2 days. These results show that trail pheromone disruption of Argentine ants is possible, but a much more durable formulation is needed before nest-level impacts can be expected. ?? 2008 Springer Science+Business Media, LLC.

  20. Human Keratinocytes Radioprotection with Mentha Longifolia

    Science.gov (United States)

    Rizzo, Angela Maria; Berselli, P.; Zava, S.; Negroni, M.; Corsetto, P.; Montorfano, G.; Bertolotti, A.; Ranza, E.; Ottolenghi, A.; Berra, B.

    Antioxidants are suggested to act as radioprotectors, and dietary supplements based on antiox-idants have been proposed for astronauts involved in long-term space missions. Plant extracts with antioxidant properties may be used in dietetic supplements for astronauts; in fact recent nutritional guidelines suggest that "fruits and vegetables may become as important on space-going vessels as limes were on the sea-going vessels of old". Mint presents a large variety of biological properties, such as antiallergenic, antibacterial, anti-inflammatory, antitumor, an-tiviral, gastrointestinal protective, hepatoprotective, chemopreventive activities, most of which are attributable to its antioxidant activity. The aim of the present study is to evaluate the antioxidant properties and protective bio-efficacy of a phenol enriched Mentha longifolia ex-tract on gamma rays stressed human keratinocytes (NCTC2544). We assessed first the in vitro antioxidant activity (ABTS and DPPH), and then evaluated different stress markers in order to investigate various oxidative stress targets: cell viability (MTT); retained proliferating ca-pability (CA); DNA damage (histone H2AX) and protein damage (HSP70 induction). Results indicate that this Mint extract has a higher antioxidant activity respect to fresh extracts, that could be responsible of its really interesting radio-protective effects.

  1. Production and Radioprotective Effects of Pyrroloquinoline Quinone

    Directory of Open Access Journals (Sweden)

    De-Xuan Yang

    2011-12-01

    Full Text Available Pyrroloquinoline quinone (PQQ was produced by fermentation of the Methylovorus sp. MP688 strain and purified by ion-exchange chromatography, crystallization and recrystallization. The yield of PQQ reached approximately 125 mg/L and highly pure PQQ was obtained. To determine the optimum dose of PQQ for radioprotection, three doses (2 mg/kg, 4 mg/kg, 8 mg/kg of PQQ were orally administrated to the experimental animals subjected to a lethal dose of 8.0 Gy in survival test. Survival of mice in the irradiation + PQQ (4 mg/kg group was found to be significantly higher in comparison with the irradiation and irradiation + nilestriol (10 mg/kg groups. The numbers of hematocytes and bone marrow cells were measured for 21 days after sublethal 4 Gy gamma-ray irradiation with per os of 4 mg/kg of PQQ. The recovery of white blood cells, reticulocytes and bone marrow cells in the irradiation + PQQ group was faster than that in the irradiation group. Furthermore, the recovery of bone marrow cell in the irradiation + PQQ group was superior to that in irradiation + nilestriol group. Our results clearly indicate favourable effects on survival under higher lethal radiation doses and the ability of pyrroloquinoline quinine to enhance haemopoietic recovery after sublethal radiation exposure.

  2. Radioprotection calculations for the TRADE experiment

    CERN Document Server

    Zanini, L; Herrera-Martínez, A; Kadi, Y; Rubbia, Carlo; Burgio, N; Carta, M; Santagata, A; Cinotti, L

    2002-01-01

    The TRADE project is based on the coupling of, in a sub-critical configuration, of a 115 MeV, 2 mA proton cyclotron with a TRIGA research reactor at the ENEA Casaccia centre (Rome). Detailed radioprotection calculations using the FLUKA and EA-MC Monte Carlo codes were performed during the feasibility study. The study concentrated on dose rates due to beam losses in normal operating conditions and in the calculation of activation in the most sensitive components of the experiment. Results show that a shielding of 1.4 m of barytes concrete around the beam line will be sufficient to maintain the effective doses below the level of 10 Mu Sv/h, provided that the beam losses are at the level of 10 nA/m. The activation level around the beam line and in the water will be negligible, while the spallation target will reach an activation level comparable to the one of a fuel element at maximum burnup.

  3. Representative parameter of immunostimulatory ginseng polysaccharide to predict radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Son, Hyeog Jin; Shim, Ji Young; Ahn, Ji Yeon; Yun, Yeon Sook; Song, Jie Young [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2008-09-15

    According to the increase in the use of radiotherapy to cancer patients, many approaches have been tried to develop new agents for the protection of surrounding normal tissues. However, it is still few applied in the clinic as a radioprotector. We aim to find a representative parameter for radioprotection to easily predict the activity of in vivo experiment from the results of in vitro screening. The polysaccharide extracted from Panax ginseng was used in this study because the immunostimulator has been regarded as one of the radioprotective agent category and was already reported having a promising radioprotective activity through the increase of hematopoietic cells and the production of several cytokines. Mitogenic activity, AK cells activity and nitric oxide production were monitored for the in vitro immunological assay, and endogenous Colony-Forming Unit (e-CFU) was measured as in vivo radioprotective parameter. The immunological activity was increased by the galactose contents of ginseng polysaccharide dependently. The result of this study suggests that mitogenic activity of splenocytes demonstrated a good correlation with in vivo radioprotective effect, and may be used as a representative parameter to screen the candidates for radioprotector.

  4. Radioprotective Effects of Hairy Roots of Ginseng

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Hyun Jung; Kim, Jin Kyu [Korea Atomic research Institute, Jeongeup (Korea, Republic of); Kim, Eun Young; Yang, Deok Cho [Chungbuk National Univ., Cheongju (Korea, Republic of)

    2005-07-01

    Panax ginseng is an important medicinal plant in Korea, which has broad efficacious effects against hypertension, diabetes, nociception and cancer. And it improves weakness. The native ginseng is a slow growing plant taking 5-7 years from seed planting to mature root harvesting, during which time much care is needed since its growth is susceptible to many environmental factors such as soil, shade, climate, pathogens and pests. Nowadays, a wild ginseng has become extremely scarce and the ginseng supply depends almost exclusively on field cultivation, which is a time-consuming and labor-intensive process. To meet the demand for the plant in the international market, a bioreactor technology is a useful tool for production of root biomass on a large scale. Therefore, suspension culture of ginseng roots in bioreactors is viewed as a primary alternative method for large-scale production and recently our laboratory has developed a protocol for the in vitro culture of P. ginseng. About 60-70% of cellular DNA damage produced by ionizing radiation is caused by OH, formed from the radiolysis of water. Oxidative stress occurs when there is an excessive free radical production and/or low antioxidant defense, and results in the chemical alterations of biomolecules causing structural and functional modifications. The generation of the reactive oxygen metabolites plays an important role in the pathogenesis of the irradiation-induced tissue injury. An extensive literature review implicates cellular DNA as the primary target for the biological and lethal effects of ionizing radiation. Besides DNA, lipids and proteins are also attacked by free radicals. The purpose of this study, aimed at investigating the possible radioprotective effect of the hairy roots of P. ginseng on irradiation-induced damage by the comet assay.

  5. Radioprotection of human endothelial cells with amifostine

    Energy Technology Data Exchange (ETDEWEB)

    Andreopoulos, D.; Schleicher, U.M.; Ammon, J. [Technische Hochschule Aachen (Germany). Klinik fuer Radiotherapie - Onkologie; Cotarelo, C.L.; Hand, S. [Technische Hochschule Aachen (Germany). Inst. fuer Pathologie

    1999-11-01

    Materials and methods: We studied the effect of amifostine on radiation sensitivity of human endothelial cells and several tumor cell lines (HeLa, MIA PaCa-2 and BxPC-3). The cells were incubated in medium with a concentration of 1 {mu}g/{mu}l amifostine and after 1 hour irradiated with 10 or 20 Gy single dose. Proliferation index was measured by BrdU assay after another 8 and 24 hours. Results: The results show a higher proliferation rate of endothelial cells following radiation plus amifostine, compared with radiation alone. Amifostine induced an increase of proliferation in the control-non-irradiated human endothelial cells. After irradiation with 10 Gy single dose the proliferation of amifostine treated human endothelial cells was still higher. Amifostine exerts no apparent proliferative effect on the tumor cells. Conclusions: The results presented indicate that amifostine acts as an activation of proliferation of the human endothelial cells in a simple in-vitro system and indicate that amifostine supplementation prior to radiation therapy might exert a radioprotective effect to healthy tissue without spurring tumor growth. (orig.) [German] Material und Methode: Humane Endothelzellen und verschiedene Tumorzellinien (HeLa, MIA PaCa-2 and BxPC-3) wurden fuer eine Stunde mit 1 {mu}g/{mu}l Amifostin inkubiert und dann mit Dosen von 10 und 20 Gy bestrahlt. Die Proliferationsaktivitaet wurde mittels BrdU-Assay nach acht und 24 Stunden gemessen. Ergebnisse: Amifostin fuehrt zu einer verstaerkten Proliferation der unbestrahlten Endothelzellen. Nach der Bestrahlung mit 10 Gy Einzeitdosis zeigen die Endothelzellen mit Amifostin-Zusatz eine staerkere Proliferation als die Zellen ohne Amifostin. Ein protektiver Effekt auf die Tumorzellinien war nicht feststellbar. Schlussfolgerung: Die bisherigen Ergebnisse zeigen, dass Amifostin einen radioprotektiven Effekt auf humane Endothelzellen ausuebt und deren Proliferation stimuliert, ohne jedoch die Proliferation der Tumorzellen

  6. Melatonin as a radioprotective agent: a review

    International Nuclear Information System (INIS)

    Melatonin (N-acetyl-5-methoxytryptamine), the chief secretory product of the pineal gland in the brain, is well known for its functional versatility. In hundreds of investigations, melatonin has been documented as a direct free radical scavenger and an indirect antioxidant, as well as an important immunomodulatory agent. The radical scavenging ability of melatonin is believed to work via electron donation to detoxify a variety of reactive oxygen and nitrogen species, including the highly toxic hydroxyl radical. It has long been recognized that the damaging effects of ionizing radiation are brought about by both direct and indirect mechanisms. The direct action produces disruption of sensitive molecules in the cells, whereas the indirect effects (∼70%) result from its interaction with water molecules, which results in the production of highly reactive free radicals such as ·OH, ·H, and eaq- and their subsequent action on subcellular structures. The hydroxyl radical scavenging ability of melatonin was used as a rationale to determine its radioprotective efficiency. Indeed, the results from many in vitro and in vivo investigations have confirmed that melatonin protects mammalian cells from the toxic effects of ionizing radiation. Furthermore, several clinical reports indicate that melatonin administration, either alone or in combination with traditional radiotherapy, results in a favorable efficacy:toxicity ratio during the treatment of human cancers. This article reviews the literature from laboratory investigations that document the ability of melatonin to scavenge a variety of free radicals (including the hydroxyl radical induced by ionizing radiation) and summarizes the evidence that should be used to design larger translational research-based clinical trials using melatonin as a radioprotector and also in cancer radiotherapy. The potential use of melatonin for protecting individuals from radiation terrorism is also considered

  7. 75 FR 53731 - Culturally Significant Objects Imported for Exhibition Determinations: “Contemporary Argentine...

    Science.gov (United States)

    2010-09-01

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Contemporary Argentine Masterworks... of August 28, 2000, I hereby determine that the objects to be included in the exhibition ``Contemporary Argentine Masterworks,'' imported from abroad for temporary exhibition within the United...

  8. Re-defining Anglo-Argentine literature: from travel writing to travelling identities

    OpenAIRE

    Ferradas, Claudia Mónica

    2011-01-01

    This study proposes a definition of Anglo-Argentine literature, a literary corpus that has not been explicitly defined, and provides a reading list of Anglo-Argentine works on the basis of that definition. The research is based on the presupposition that Anglo-Argentine texts can be used to contribute to an intercultural approach to language and literature teaching in the Argentine higher education context. Such texts can encourage reflection on how writing on Argentina in English has co...

  9. Phytochemicals with radioprotection and radio-sensitizing potential

    International Nuclear Information System (INIS)

    Ionizing radiation induces DNA damage and are harmful to mankind. They act through free radical generation, which target the double bonds of all cellular macromolecules. The radiation damage may be classified as probabilistic or deterministic, depending on the dose of radiation exposure. Since radiation affects multiple organs so those drugs which protect many organs, would be more beneficial. In this process herbal extracts, which are cocktail of several phyto-chemicals, would be more promising. Initially sulphur containing bio-molecules were identified as radio-protector, but now many secondary metabolites from plant kingdom, have been reported to be radio-protective. They have different mechanism of action, but most of them either prevent the FR induced DNA damage or accelerate the DNA repair process. Aminofostine, WR-2721, 159243, 2926 are some of the examples. However they have limited use because of associated cytotoxicity. Eicosanoids, topoisornerase inhibitors (e.g. camptothecin, topotecan), and the hypoxia-activated anthraquinone AQ4N have shown radioprotecting potential. Several plant products, derived from Tulsi, Vinca alkaloids, taxans, turmeric, Rubia cordifolia, Semecarpus anacardium and several plants rich in polyphenols and flavones have shown hemotherapeutic potential. Similarly, Hippophae, rhodiola imbricata, Podophyllum hexandrum, Ocimum sancturn, Plumbago zeylanica etc have shown radioprotection. Rubia cordifolia has shown both chemotherapeutic and radioprotective property in rats and A-431 cells. Similarly Semecarpus anacardium extract has shown cell cycle arrest in DU-145 cells. (author)

  10. Radioprotection et ingénierie nucléaire

    CERN Document Server

    2006-01-01

    Le développement de l'énergie nucléaire repose sur deux piliers essentiels : la sûreté nucléaire, qui concerne la machine, et la radioprotection, qui se préoccupe des hommes. Construit de manière fiable, un réacteur nucléaire se doit d'irradier le moins possible ses opérateurs et conduire à un impact très faible pour les populations avoisinantes. Tout cela est soumis à des règles strictes, élaborées au niveau international, et qui ne tolèrent aucun écart. Les ingénieurs qui ont à concevoir, construire et conduire ces machines doivent maîtriser les règles de protection : cet ouvrage leur est destiné. La radioprotection, si elle se fonde principalement sur des bases scientifiques, intègre également une dimension sociétale exigeante. Ces activités sont en effet sous le regard critique et permanent de nos concitoyens, qui exigent des acteurs de cette industrie une maîtrise totale de la radioprotection ; un ingénieur qui ne connaîtrait pas la genèse de la radioprotection, ses règle...

  11. Genetic predisposition and implications for radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Streffer, Christian [University Clinics, Essen, Essen (Germany)

    2000-05-01

    retinoblastoma who did not have a genetic predisposition. Mainly osteoblastoma and soft tissue sarcoma were observed in the former radiation field. From these date it must be concluded that such effects also occur in the low dose range. Individuals with the extreme radiosensitivity (dose modifying factor, DMG, of around 5) are rare, but there are individuals with a DMF of around 1.5 to 2 who are more frequent. Therefore it has to be discussed whether the individual variability of radiosensitivity must also be considered for radioprotection by special dose limits or other regulations. (author)

  12. Use of remote sensing and GIS to identify Flamingo habitat in the Argentine Altiplano

    Science.gov (United States)

    Boyle, Susan C.; Hoffer, Roger M.; Boyle, Terence P.; Bucher, Enrique H.

    1992-01-01

    The Argentine altiplano is a remote area which has never been adequately mapped. It is an arid region with harsh climate, little vegetation, sparse population, and an average elevation of over 3,500 feet. Little is known about the large populations of three species of flamingos which nest and feed in the altiplano lakes. In a study funded by the National Geographic Society satellite data (Landsat MSS and TM data) were used to map the location of major water bodies and to analyze the spectral characteristics of the aquatic ecosystems in the altiplano. A comparison of the two images revealed dramatic changes in the size, depth, and spectral reflectance of the lakes utilized by the flamingos.

  13. Maintaining Roads : The Argentine Experience with Output-Based Contracts

    OpenAIRE

    Liautaud, Gerard

    2001-01-01

    The Argentine government is using output-based contracts with the private sector for rehabilitation and maintenance of its nonconcessioned road network. The multiyear lump sum contracts, funded by the government, specify required road service outputs and use incentive-based payment schedules to ensure the quality of the work. After three years of operation the 60 contracts (averaging US$10...

  14. A view on the future of Argentine nuclear exports

    International Nuclear Information System (INIS)

    In order to anticipate the possibilities of future nuclear technology exports, the technological capacities of the organizations and companies that make up the Argentine nuclear sector are analyzed together with the evolution of their possible markets. The main export opportunities are seen in the field of the research reactors, nuclear fuel elements, heavy water and radioisotopes for medical and industrial applications

  15. Sino-Argentine SLR station making new progress

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The Sino-Argentine satellite laser ranging (SLR) system ranks second in the pass total of satellites it has observed among the SLR satellite observatories worldwide, according to statistics of the International Laser Ranging Service from October 2007 to September 2008. In addition, it tops the world in observing high orbit satellites, a difficult task to perform.

  16. The Mindful Attention Awareness Scale (MAAS) in an Argentine Population

    Science.gov (United States)

    Montes, Silvana Andrea; Ledesma, Rubén Daniel; García, Natalia Mariana; Poó, Fernando Martín

    2014-01-01

    The purpose of this study was to provide evidence of validity for the Mindful Attention Awareness Scale scores in an Argentine sample (Spanish-language version). Results indicated satisfactory psychometric properties (a one-factor structure, good item discrimination, high reliability, and significant correlations with additional measures). This…

  17. The radioprotective effect of a new aminothiol (20-PRA

    Directory of Open Access Journals (Sweden)

    M.F. Dolabela

    1998-08-01

    Full Text Available We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA on a human leukemic cell line (K562 following various radiation doses (5, 7.5 and 20 Gy using a source of 60Co g-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58% was seen 24 h after irradiation, followed by a decrease at 48 h (11%. At the high radiation dose (20 Gy a low protective effect was also seen (35%. In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl-1,3-diaminopropane whose protective effect is in the 0.1 to 1.0 mM range.

  18. Radioprotection of vitamin D on mice injured by irradiation

    International Nuclear Information System (INIS)

    To investigate the radioprotective effect of vitamin D against irradiation injury, the mice exposed to 60Co γ-rays at 6 Gy was treated with preparation of vitamin D(Alfacalcidol Soft Capsules). Cell cycle and apoptosis was analyzed by flow cytometry (FCM) following staining of cells with propidium iodide (PI). Peripheral blood cell counts were analyzed by autoanalyzer. It has been found that vitamin D significantly increases white blood cell (WBC) counts, decreases bone marrow PEC micronucleus rate. FCM analysis shows that compared with damaged group, G2 and S phases of bone marrow cells in vitamin D protection group increases significantly at 24 h after whole body irradiation, whereas G1 phase cells decrease at the same times. So vitamin D might be a new radioprotection agent and it should be deserved further study. (authors)

  19. Effect of radioprotective biogenic amines on peroxide oxidation of lipids in rat small intestine mucosa microsomes

    International Nuclear Information System (INIS)

    The radioprotective biogenic amines, dopamine, histamine, and serotonin inhibited lipid peroxidation in rat small intestine mucosal microsomes. Possible mechanisms of these inhibitory effects are discussed

  20. Study on the radioprotective effect of cystamine and mexamine during two subsequent mitotic cycles

    Energy Technology Data Exchange (ETDEWEB)

    Sidorov, V.P. (Vsesoyuznyj Nauchno-ssledovatel' skij Inst. I Khimizatsii Lesnogo Khozyajstva, Pushkino (USSR))

    The radioprotective agents were found to be effective in relation to chromosomal aberrations occuring during both the first and the second mitotic cycles. It was shown that the radioprotective effect of cystamine and mexamine is completely removed by the effect of the inhibitor of DNA synthesis, 5-aminouracil. It is suggested that the radioprotective effect of the protective agents is realized through the formation of complexes between the radioprotective agent and the genetically active loci of chromosome DNA rather than through the reduction of radiation-induced DNA lesions.

  1. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis

    OpenAIRE

    Seed, Thomas M.; Inal, Cynthia E.; Singh, Vijay K

    2014-01-01

    Purpose Amifostine is a highly efficacious cytoprotectant when administered in vivo at high doses. However, at elevated doses, drug toxicity manifests for general, non-clinical radioprotective purposes. Various strategies have been developed to avoid toxic side-effects: The simplest is reducing the dose. In terms of protecting hematopoietic tissues, where does this effective, non-toxic minimum dose lie? Material and methods C3H/HEN mice were administered varying doses of amifostine (25–100 mg...

  2. Proton irradiation of stem cells: Radiation damage and chemical radioprotection

    Science.gov (United States)

    Riley, R. C.; Montour, J. L.; Gurney, C. W.

    1972-01-01

    Effects of high energy protons on erythropoietic stem cells and radioprotection by chemicals were investigated in NASA Space Radiation Effects Laboratory. The effects of a parallel beam of 600 MeV protons. The fluence, when converted to dose, were referenced to the synchrocyclotron beam monitors which were then used to administer radiation exposures. Mice were given graded doses to 300 rads to determine dose-response curve. Other mice received saline, AET, or 5-hydroxytryptamine 10 to 15 minutes before exposure.

  3. Proceedings of the 14. Congress of the Maria Sklodowska-Curie Polish Radiation Society

    International Nuclear Information System (INIS)

    Held every three years Congress of the Polish Radiation Research Society presents the latest achievements in the radiation research. In 2007 participants presented 9 plenary lectures, 38 section lectures and 61 posters. Communications and posters covered four disciplines: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) non-ionizing radiation, (d) radioprotection and the environmental radiation

  4. Radioprotective effect of GABA-tropic substances, γ-hydroxybutyrate and pyracetame

    International Nuclear Information System (INIS)

    From experiments in mice, it is shown that with a radiation dose of 8 Gy (LD96) the radioprotective effect was exerted by gamma-aminobutyric acid (GABA), substances that increase its concentration in tissues (progabide and valproate), and synthetic agonists of both receptor types, particularly baclofen, a GABA-receptor agonist. The radioprotective effect is also exerted by gamma-hydroxybutyrate, not pyracetame

  5. Radioprotection, biological effects of the radiations and security in the handling of radioactive material

    CERN Document Server

    Teran, M

    2000-01-01

    The development of the philosophy of the radioprotection is dependent on the understanding of the effects of the radiation in the man. Behind the fact that the radiation is able to produce biological damages there are certain factors with regard to the biological effects of the radiations that determine the boarding of the radioprotection topics.

  6. A study of the radioprotection effect of guarana (Paullinia cupana) on the fetuses of ICR mice

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Yeun Hwa; Hasegawa, Takeo; Yamamoto, Youichi; Suzuki, Ikukatsu [Suzuka Univ. of Medical Science, Suzuka (Japan); Yoon, Yeog Byung [Shinheung college, Uijeongbu (Korea, Republic of); Rhee, Soo Yong [Hanyang Univ., Seoul (Korea, Republic of)

    2001-12-15

    Guarana, a tropical plant is found in powdered for in health food and is very popular soft drink in Brazil as an energy feaster with its high caffeine contents. We examined its radioprotection effects during organogenesis stages of ICR mice by malformations rate and cellular lead 8 the embryo by radiation and analyzed the mechanism of the radioprotection effects in the fetal of ICR mice. The results of this study showed that Guarana reduced clearly the embryonic death rate and teratogenesis rate by radiation. Its radioprotection effect inject be related with its radioprotection effect might be related with its antioxidant effect or free radical scavenger. We need to exposure the Guarana as a potential radioprotection agent. Therefore, we investigated about radiation effects by Guarana using to mice experiments in this paper.

  7. Other-initiated repair in Argentine Sign Language

    OpenAIRE

    Manrique Elizabeth

    2016-01-01

    Other-initiated repair is an essential interactional practice to secure mutual understanding in everyday interaction. This article presents evidence from a large conversational corpus of a sign language, showing that signers of Argentine Sign Language (Lengua de Señas Argentina or ‘LSA’), like users of spoken languages, use a systematic set of linguistic formats and practices to indicate troubles of signing, seeing and understanding. The general aim of this article is to provide a...

  8. Networks in Argentine agriculture: a multiple-case study approach

    OpenAIRE

    Sebastián Senesi; Fabio Ribas Chaddad; Hernán Palau

    2013-01-01

    Argentina is among the four largest producers of soybeans, sunflower, corn, and wheat, among other agricultural products. Institutional and policy changes during the 1990s fostered the development of Argentine agriculture and the introduction of innovative process and product technologies (no-till, agrochemicals, GMO, GPS) and new investments in modern, large-scale sunflower and soybean processing plants. In addition to technological changes, a "quiet revolution" occurred in the way agricultu...

  9. Liquid baits control Argentine ants sustainably in coastal vineyards

    OpenAIRE

    Cooper, Monica L; Daane, Kent M.; Nelson, Erik H; Varela, Lucia G; Battany, Mark; Tsutsui, Neil D.; Rust, M K

    2008-01-01

    Liquid ant baits are an alternative to broad-spectrum insecticide sprays conventionally used to control Argentine ants. We review the development of liquid ant baits, which capitalize on the ants’ sugar-feeding requirements and social structure to deliver small doses of toxicant throughout the colony. The ant bait program described here, developed for commercial vineyards, also has the potential to facilitate the use of biological controls for mealybug and scale pests. The implementation of a...

  10. Radioprotection optimization in the electronuclear, industrial and medical domains

    International Nuclear Information System (INIS)

    This document gathers the slides of the available presentations given during these conference days. Thirty one presentations are assembled in the document and deal with: 1 - implementation of the ALARA principle in the nuclear, industrial and medical domains: status and challenges (C. Schieber); 2 - image quality and scanner irradiation: what ingredients to chose? (T. Solaire); 3 - radioprotection stakes and implementation of the ALARA approach during the IFMIF design (Y. Le Tonqueze); 4 - ALARA at the design stage of the EPR (P. Jolivet); 5 - alternative techniques to iridium 192 gamma-graphy for welds control: results and recommendations from the ALTER-X project (D. Chauveau); 6 - alternative techniques to ionizing radiations use in the medical domain: implementation of navigation strategies (L. Mathevet); 7 - justification of ionizing radiations use in non-medical imaging: overview of the French situation and perspectives status (S. Rodde); 8 - ISOE: task scheduling for radioprotection optimization in nuclear power plants (G. Abela); 9 - Practices and ALARA prospects among big nuclear operators (T. Juhel); 10 - experience feedback on the use of diagnostic reference levels (DRLs) in diagnostic imaging optimization (L. Mertz); 11 - DRLs: Swiss strategy and concept limits (F.O. Bochud); 12 - external dosimetry tools: the existing, the developing and the remaining problems (A. Rannou); 13 - is the optimization principle applicable to the aircraft personnel's exposure to cosmic radiation? (G. Desmaris); 14-15 - experience feedback of the ALARA approach concerning an operation with strong dosimetric stakes (P. Mougnard and N. Fontaine); 16 - optimization of reactor pool decontaminations ((P. Tranchant); 17 - radiopharmaceuticals transport - ALARA principle related stakes (G. Turquet de Beauregard); 18 - ALARA in vet radio-diagnosis activity: good practices guide (C. Roy); 19 - implementation of the ALARA approach at the Proton-therapy centre of Orsay's Curie Institute

  11. Radioprotection of targeted and bystander cells by methylproamine

    Energy Technology Data Exchange (ETDEWEB)

    Burdak-Rothkamm, Susanne [Queen' s University Belfast, Centre for Cancer Research and Cell Biology, Belfast (United Kingdom); Oxford University Hospitals, Cellular Pathology, Oxford (United Kingdom); Smith, Andrea; Lobachevsky, Pavel; Martin, Roger [Peter MacCallum Cancer Centre, Molecular Radiation Biology Laboratory, Melbourne (Australia); University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne (Australia); Prise, Kevin M. [Queen' s University Belfast, Centre for Cancer Research and Cell Biology, Belfast (United Kingdom)

    2014-09-23

    Radioprotective agents are of interest for application in radiotherapy for cancer and in public health medicine in the context of accidental radiation exposure. Methylproamine is the lead compound of a class of radioprotectors which act as DNA binding anti-oxidants, enabling the repair of transient radiation-induced oxidative DNA lesions. This study tested methylproamine for the radioprotection of both directly targeted and bystander cells. T98G glioma cells were treated with 15 μM methylproamine and exposed to {sup 137}Cs γ-ray/X-ray irradiation and He{sup 2+} microbeam irradiation. Radioprotection of directly targeted cells and bystander cells was measured by clonogenic survival or γH2AX assay. Radioprotection of directly targeted T98G cells by methylproamine was observed for {sup 137}Cs γ-rays and X-rays but not for He{sup 2+} charged particle irradiation. The effect of methylproamine on the bystander cell population was tested for both X-ray irradiation and He{sup 2+} ion microbeam irradiation. The X-ray bystander experiments were carried out by medium transfer from irradiated to non-irradiated cultures and three experimental designs were tested. Radioprotection was only observed when recipient cells were pretreated with the drug prior to exposure to the conditioned medium. In microbeam bystander experiments targeted and nontargeted cells were co-cultured with continuous methylproamine treatment during irradiation and postradiation incubation; radioprotection of bystander cells was observed. Methylproamine protected targeted cells from DNA damage caused by γ-ray or X-ray radiation but not He{sup 2+} ion radiation. Protection of bystander cells was independent of the type of radiation which the donor population received. (orig.) [German] Radioprotektive Agenzien sind sowohl in der Strahlentherapie von Krebserkrankungen als auch im Strahlenschutz im Zusammenhang mit akzidenteller Exposition von Bedeutung. Methylproamine ist die Leitsubstanz einer Klasse von

  12. Argentine Population Genetic Structure: Large Variance in Amerindian Contribution

    Science.gov (United States)

    Seldin, Michael F.; Tian, Chao; Shigeta, Russell; Scherbarth, Hugo R.; Silva, Gabriel; Belmont, John W.; Kittles, Rick; Gamron, Susana; Allevi, Alberto; Palatnik, Simon A.; Alvarellos, Alejandro; Paira, Sergio; Caprarulo, Cesar; Guillerón, Carolina; Catoggio, Luis J.; Prigione, Cristina; Berbotto, Guillermo A.; García, Mercedes A.; Perandones, Carlos E.; Pons-Estel, Bernardo A.; Alarcon-Riquelme, Marta E.

    2011-01-01

    Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies. PMID:17177183

  13. From human to environmental radioprotection: Some crucial issues worth considering

    International Nuclear Information System (INIS)

    The need to establish a system capable of ensuring adequate protection of the environment from the harmful effects of ionising radiation is at present particularly challenged. This comes both from a restrictive consideration of the environment in the so far existing system for human radioprotection, and the planetary-wide growing concerns about man's technogenic influence on his environment which have yielded 'sustainability' and 'precaution' as guiding principles for environmental protection. For the sake of protection, the environment is traditionally addressed through its biota since these are the sensitive components of ecosystems. Similarities between man and biotas root from the ubiquitous mechanistic effects of radiation on life which disrupt molecules. However, important differences also arise in a number of perspectives, from the vast biodiversity of species with a large spectrum of radio-sensitivities to their hierarchical self-organisation as interacting populations within ecosystems. Altogether, these aspects are prone to promote complex arrays of different responses to stress which lie beyond the scope of human radioprotection which only considers individuals of one single species. The focus on individuals in a bottom-up approach, due to its easier amenability to quantification, has prompted the development of current ecotoxicological methods as a scientific foundation to regulating environmental protection. Exclusive basement of Ecological Risk Assessment on this reductionist approach, however, is currently questioned by the most recent ecological theories which call for additional consideration of more holistic, top-down, approaches. In moving from man to environment radioprotection, these current challenges are discussed by highlighting some crucial issues linked to setting up dose limits in chronic exposure, weighting them according to radiation types (RBE), identifying appropriate effect endpoints (stochastic/deterministic, individual

  14. Proceedings of 5. French speaking scientific days on calculation codes for radioprotection, radio-physics and dosimetry

    International Nuclear Information System (INIS)

    These scientific days were organised by the 'technical protection' Section of the French Society of Radiation Protection (SFRP) in cooperation with the French society of medical physicists (SFPM), the Swiss Romandie association of radioprotection (ARRAD) and the associated laboratories of radio-physics and dosimetry (LARD). The objective of these days was to review the existing calculation codes used in radiation transport, source estimation and dose management, and to identify some future prospects. This document brings together the available presentations (slides) together with their corresponding abstracts (in French) and dealing with: 1 - Presentation of the conference days (L. De Carlan); 2 - Simulating radionuclide transfers in the environment: what calculation codes and for what? (C. Mourlon); 3 - Contribution of Monte-Carlo calculation to the theoretical foundation analysis of calibration procedures and dosemeters design for radioprotection photon dosimetry (J.M. Bordy); 4 - Use of calculation codes in R and D for the development of a new passive dosemeter for photons and beta radiations (B. Moreno); 5 - Development of a new virtual sources model for the Monte-Carlo prediction of EPID (Electronic Portal Imaging Device) images and implementation in PENELOPE (I. Chabert); 6 - Prediction of high-resolution EPID images for in-vivo dosimetry (D. Patin); 7 - 4D thorax modeling by artificial neural networks (P.E. Leni); 8 - Presentation of the calculation utilities of the book 'Calculation of ionizing radiations generated doses' (Vivier, Lopez, EDP Sciences 2012) (A. Vivier); 9 - RayXpertC: a 3D modeling and Monte-Carlo dose rate calculation software (C. Dossat); 10 - TRIPOLI-4R Version 9 S Monte-Carlo code for radioprotection (F. Damian); 11 - Realistic radioprotection training with the digital school workshop (E. Courageot); 12 - Use of BEAMNRC code for dental prostheses influence evaluation in ENT cancers treatment by external radiotherapy (C. De Conto); 13

  15. Radioprotection optimization in the electronuclear, industrial and medical domains; Optimisation de la radioprotection dans les domaines electronucleaire, industriel et medical

    Energy Technology Data Exchange (ETDEWEB)

    Schieber, C.; Abela, G.; Ammerich, M.; Balduyck, S.; Batalla, A.; Drouet, F.; Fracas, P.; Gauron, Ch.; Le Guen, B.; Lombard, J.; Mougnard, Ph.; Murith, Ch.; Rannou, A.; Rodde, S.; Selva, M.; Tranchant, Ph.; Schieber, C.; Solaire, T.; Le Tonqueze, Y.; Jolivet, P.; Chauveau, D.; Mathevet, L.; Juhel, T.; Mertz, L.; Bochud, F.O.; Desmaris, G.; Turquet de Beauregard, G.; Roy, C.; Delacroix, S.; Sevilla, A.; Rehel, J.L.; Bernhard, S.; Palut-Laurent, O.; Lochard, J.; Lebaron-Jacobs, L.; Wack, G.; Barange, K.; Delabre, H.

    2011-07-01

    This document gathers the slides of the available presentations given during these conference days. Thirty one presentations are assembled in the document and deal with: 1 - implementation of the ALARA principle in the nuclear, industrial and medical domains: status and challenges (C. Schieber); 2 - image quality and scanner irradiation: what ingredients to chose? (T. Solaire); 3 - radioprotection stakes and implementation of the ALARA approach during the IFMIF design (Y. Le Tonqueze); 4 - ALARA at the design stage of the EPR (P. Jolivet); 5 - alternative techniques to iridium 192 gamma-graphy for welds control: results and recommendations from the ALTER-X project (D. Chauveau); 6 - alternative techniques to ionizing radiations use in the medical domain: implementation of navigation strategies (L. Mathevet); 7 - justification of ionizing radiations use in non-medical imaging: overview of the French situation and perspectives status (S. Rodde); 8 - ISOE: task scheduling for radioprotection optimization in nuclear power plants (G. Abela); 9 - Practices and ALARA prospects among big nuclear operators (T. Juhel); 10 - experience feedback on the use of diagnostic reference levels (DRLs) in diagnostic imaging optimization (L. Mertz); 11 - DRLs: Swiss strategy and concept limits (F.O. Bochud); 12 - external dosimetry tools: the existing, the developing and the remaining problems (A. Rannou); 13 - is the optimization principle applicable to the aircraft personnel's exposure to cosmic radiation? (G. Desmaris); 14-15 - experience feedback of the ALARA approach concerning an operation with strong dosimetric stakes (P. Mougnard and N. Fontaine); 16 - optimization of reactor pool decontaminations ((P. Tranchant); 17 - radiopharmaceuticals transport - ALARA principle related stakes (G. Turquet de Beauregard); 18 - ALARA in vet radio-diagnosis activity: good practices guide (C. Roy); 19 - implementation of the ALARA approach at the Proton-therapy centre of Orsay's Curie

  16. Radioprotective potential of an herbal extract of Tinospora cordifolia

    International Nuclear Information System (INIS)

    A preparation of Tinospora cordifolia (RTc) administered i.p. (200 mg/kg b.w.) to strain 'A' male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (CFU), hematological parameters, cell cycle progression, and micronuclei induction. Preirradiation treatment with RTc rendered 76.3% survival (30 days), compared to 100% mortality in irradiated control and prevented radiation induced weight loss. On 10th postirradiation day, the endogenous CFU counts in spleen were decreased with increasing radiation doses 12.0 (5 Gy), 2.16 (7.5 Gy) and 0.33 (10 Gy) but pre-irradiation administration of 200 mg/kg b.w. of RTc increased CFU counts to 31.16, 21.83 and 3.00 respectively. Pre-irradiation RTc treatment could restore total lymphocyte counts (TLC) by the 15th day to normal. It also increased the S-phase cell population that was reduced following 2 Gy irradiation in a time dependent manner. Two Gy irradiation-induced micronuclei were also decreased by a pre-irradiation administration of RTc from 2.9 to 0.52%. Because the radioprotective manifestation of RTc observed in several systems in experimental animals can be exploited for human applications. (author)

  17. The radioprotective potential of 3,5,4'-trihydroxystilbene

    International Nuclear Information System (INIS)

    The radioprotective potential of 3,5,4'trihydroxystilbene or resveratrol, a compound abundant in grapes, was investigated using the micronucleus test. Gamma radiation (6 Gy) was used to induce micronucleus formation in 12-week old Swiss-Webster mice. Five groups with five mice each were used. Three groups were given corresponding treatments (low, normal, high doses of reservatrol) via oral gavage for one week. The negative control group was not given any radiation nor any compound while the positive control group was exposed to radiation but was not given any compound. The mean micronucleus frequencies arranged from highest to lowest are as follows: low dose, positive control, normal dose, high dose and negative control. Using the analysis of variance-complete random design followed by the Duncan multiple range test, it was proven that resveratrol was able to inhibit micronucleus formation in polychromatic erythrocytes of 12-week old Swiss-Webster mice at the normal (60 micrograms) and high (120 micrograms) concentrations assigned. This suggests that its radioprotective potential may follow a dose-dependent pattern. (Author)

  18. Radioprotective properties of a factor isolated from deinococcus radiodurans

    International Nuclear Information System (INIS)

    Several organisms are capable of surviving high doses of ionizing radiation. Among the radioresistant organisms are some members of the Deinococcus family of bacteria, including D. radiodurans. It has been shown that an extract isolated from D. radiodurans confers radioprotection to a more radiosensitive strain of bacteria ia, E. coli. The authors' laboratory has investigated the radioprotective effects of a low molecular weight factor isolated from D. radiodurans in mice. Male CD2F1 mice were injected intraperitoneally with the factor 60 minutes prior to irradiation with 1000 rads (colbalt-60). Irradiated mice treated with 150 mg/kg of the factor showed increased survival and protection against weight loss compared to irradiated controls. When the dosage was increased, toxicity of the factor resulted in 30% mortality of the treated mice within 6 days after irradiation. These premature deaths were not observed in control mice. However, despite the toxicity at the higher dose, the 30-day survival of the remaining factor-treated mice was increased compared to controls

  19. Challenge of sustainable development in the nuclear field: Research as a vital component of nuclear safety and radioprotection policies

    International Nuclear Information System (INIS)

    The challenge of sustainable development also applies to the nuclear field: the careful management of natural resources, the preservation of the environment, and the response to society's expectations for increased transparency, and for the efficient control of risks associated with nuclear technologies are certainly key issues for this sector. Risk oriented R and D and associated scientific expertise are a key element of defence in depth for optimal nuclear safety and radioprotection. As such, a capacity to maintain worldwide the critical mass of research needed to address the main security related issues in support of public policies is vital for the continuing acceptance of nuclear activities, and of their development where needed. These issues concern both existing and future technologies. They are related to operational safety and radioprotection, to environmental protection and to public health issues, particularly with respect to nuclear waste management. They also concern security, at a time when the risk of terrorism in all its potential forms must be addressed. Nuclear and radiological R and D is characterized by the high cost and sophistication of experimental facilities, and by the high degree of knowledge and experience required to run such research programmes. Pooling of resources at the international and European level, and increasing cooperation between research organizations on the basis of an active policy towards scientific excellence and exemplary human resource management are essential, because research resources are growing scarce, in order to keep risk related research abreast of evolving technologies and industry practice, and of society's expectations for the control of nuclear and radiological risks. This is particularly true for the maintaining of key reference experimental platforms, such as safety dedicated research reactors, and for the development of complex safety related computer codes. The 'networks of excellence' promoted through

  20. Multiple oscillatory modes of the Argentine Basin. Part II. The spectral origin of the basin modes

    NARCIS (Netherlands)

    Weijer, W.; Vevier, F.; Gille, S.T.; Dijkstra, H.A.

    2007-01-01

    In this paper the spectrum of barotropic basin modes of the Argentine Basin is shown to be connected to the classical Rossby basin modes of a flat-bottom (constant depth), rectangular basin. First, the spectrum of basin modes is calculated for the Argentine Basin, by performing a normal-mode analysi

  1. XXXVIII Annual meeting of the Argentine Association of Nuclear Technology (AATN 2011)

    International Nuclear Information System (INIS)

    The 38th Annual meeting of the Argentine Association of Nuclear Technology was organized by the AATN (Asociacion Argentina de Tecnologia Nuclear) in Buenos Aires, Argentine, between the 14 and 18 November of 2011. In this event 146 papers in 16 Sessions, with 13 Plenary Conferences and 3 Roundtables were presented.

  2. Radioprotective properties of casein phospho peptides (CPP) in gamma irradiated animal models

    International Nuclear Information System (INIS)

    In search of radioprotective food supplement the antigenotoxic role of casein phospho peptides (CPP) from fermented milk were tested in animal models using fish and Swiss albino mice. The antigenotoxic property was assayed by comparing the number of micronuclei, binucleated and multinucleated erythrocytes formed in the unfed control mice and fish with the CPP fed test mice and fish cells. The antigenotoxic property of CPP proved of its radioprotective nature. This potential can be harnessed to develop a new class of radioprotective nutraceuticals which would be of immense help as food supplement for workers working with low background radiation and who are in constant exposure to natural radiation. (author)

  3. Assessment of food calcium radioprotection effectiveness against cesium-137, added alone and with iodine-131

    International Nuclear Information System (INIS)

    New fish product with addition of food calcium had radioprotective properties, resulted in decreased cesium-137 content in organs and tissues of animals by 40-60% and lesser changes in differential blood count and biochemical indexes of blood serum

  4. Radioprotection from design to exploitation of radioactive material transport packaging

    International Nuclear Information System (INIS)

    The author gives an overview of the various aspects, methods and trends related to the design, test and use of packaging used for the transportation of radioactive materials. He evokes the currently existing calculation methods and codes which are used to assess irradiation sources and to study the propagation of such irradiation through matter. He discusses the qualification process of a radioprotection calculation scheme and gives and comments comparison between computed and measured results of effective dose flow rate about packaging. He presents the 'Transportability' tool which uses a database of fuel assembly characteristics, a code to assess neutron and gamma sources, a packaging model used to compute the different contributions to effective dose flow rates, a validation stage, and a fixed margin

  5. Free radical scavenging and radioprotective effects of carnosine and anserine

    Energy Technology Data Exchange (ETDEWEB)

    Fu Haiying [Nuclear Professional School, School of Engineering, University of Tokyo, 2-22 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1188 (Japan); Katsumura, Yosuke [Nuclear Professional School, School of Engineering, University of Tokyo, 2-22 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1188 (Japan); Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1195 (Japan); Department of Nuclear Engineering and Management, School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)], E-mail: katsu@n.t.u-tokyo.ac.jp; Lin Mingzhang [Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1195 (Japan); Muroya, Yusa; Hata, Kuniki [Nuclear Professional School, School of Engineering, University of Tokyo, 2-22 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1188 (Japan); Fujii, Kentaro; Yokoya, Akinari; Hatano, Yoshihiko [Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakata shirane, Tokaimura, Nakagun, Ibaraki 319-1195 (Japan)

    2009-12-15

    Two histidine-containing natural dipeptides, carnosine and anserine ({beta}-alanyl-1-methyl-L-histidine), have been examined for their antioxidant and radioprotective abilities. Pulse radiolysis studies indicated the antioxidative properties of carnosine and anserine aqueous solutions at different pH. The rate constants for the reaction OH radical with carnosine at neutral pH were determined to be 5.3x10{sup 9} M{sup -1} s{sup -1} at 300 nm, and 4.1x10{sup 9} M{sup -1} s{sup -1} at 400 nm, respectively. Carnosine and anserine also protected plasmid pUC18 DNA from X-ray radiation-induced strand breaks as evidenced from the studies by agarose gel electrophoresis. Carnosine showed higher protective efficiency under the experimental conditions. Our data demonstrated that carnosine and anserine may play an important role in the maintenance of the antioxidant system.

  6. Free radical scavenging and radioprotective effects of carnosine and anserine

    Science.gov (United States)

    Fu, Haiying; Katsumura, Yosuke; Lin, Mingzhang; Muroya, Yusa; Hata, Kuniki; Fujii, Kentaro; Yokoya, Akinari; Hatano, Yoshihiko

    2009-12-01

    Two histidine-containing natural dipeptides, carnosine and anserine (β-alanyl-1-methyl- L-histidine), have been examined for their antioxidant and radioprotective abilities. Pulse radiolysis studies indicated the antioxidative properties of carnosine and anserine aqueous solutions at different pH. The rate constants for the reaction OH radical with carnosine at neutral pH were determined to be 5.3×10 9 M -1 s -1 at 300 nm, and 4.1×10 9 M -1 s -1 at 400 nm, respectively. Carnosine and anserine also protected plasmid pUC18 DNA from X-ray radiation-induced strand breaks as evidenced from the studies by agarose gel electrophoresis. Carnosine showed higher protective efficiency under the experimental conditions. Our data demonstrated that carnosine and anserine may play an important role in the maintenance of the antioxidant system.

  7. Radioprotective properties of DNA methylation-disrupting agents

    International Nuclear Information System (INIS)

    5-Azacytidine and sodium butyrate, two DNA methylation-disrupting agents, were tested for radioprotective properties on V79A03 cells. Both compounds can activate genes not previously expressed (e.g. metallothionein). 5-Azecytidine treatment (3 μM, 24h) caused a 50% decrease in the 5-methylcytosine content of V79A03 DNA whereas sodium butyrate treatment (1 mM, 24h) resulted in a 700% increase in 5-methylcytosine content. Additionally, 5-azacytidine treatment resulted in the increased survival of V79A03 cells, with treatment 24 h prior to exposure to gamma radiation providing a dose reduction factor of 1.8. Sodium butyrate treatment did not result in a significant increase in survival. These results indicate that the hypomethylation of genomic DNA prior to exposure to gamma radiation correlates with an increase in survival of V79A03 cells, possibly due to the activation of the enzymes involved in repair. (author)

  8. Natural products as radioprotective agents; past, present and future

    International Nuclear Information System (INIS)

    The use of ionizing radiation, which is the cornerstone of cancer treatment, is compromised by the radiosensitivity of normal tissues. A chemical that can give selective benefit to the normal cells against the deleterious effects of ionizing radiation has been a long sought goal. However, most of the compounds studied have shown inadequate clinical application owing to their inherent toxicity, undesirable side effects, and high cost. Plants commonly used as dietary and or therapeutic agents have recently been the focus of attention since in most cases they are non-toxic and are easily accepted for human use. The proposed talk will mainly deal on the radioprotective potential of some important plant and herbal extracts. (author)

  9. Status report 1976 on radioprotective action of some drugs

    International Nuclear Information System (INIS)

    The radioprotecting effect of several tranquilizers or antiepileptic drugs (Equanil, Largactil, Nozinan, Depakine, Rimifon, Polaramine, Insulin, Glutamag, Transfusine), against gamma radiation was investigated in mice. The radiation dose was LD 100/30 (evaluated to be between 900 and 1000 R as a function of mice strain). The tests performed were based on the evaluation of survival fractions after 30 days. The mice were given the drugs at the maximum tolerated dose. For each drug, the following results were given: MST 30 which is the mean survival time calculated for a 30 days period and ST 50 which is the time leading to 50% survivors. Among the various drugs tested Polaramine led to the best results

  10. Development of Functional Foods and Advanced Technology for Radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Sung Kee; Byun, Myung Woo; Kim, Jin Kyu (and others)

    2003-05-15

    We have previously developed two medicinal herb mixtures that protects immune/hematopoietic system and self-renewal tissues against irradiation and enhances immune/hematopoietic functions. In this study, we have developed two pilot products by adding the effective fractions to the hot water extract of the herb mixtures and investigated their efficacy. In irradiated mice, pilot products protected hematopoietic stem cells, promoted the regeneration and activation of immune cells, normalized the unbalanced immune reaction, and inhibited the growth of cancer cells. Polysaccharide was active fraction and mechanisms were elucidated. The products also protected the stem cells in self-renewal tissues. DNA/membrane damages, apoptotic cell signals, chromosome/DNA alterations, and oxidation of protein/lipid were inhibited by pilot products, and their radical scavenging activities were observed. Five active components were isolated and identified. Pilot products also inhibited the cancer development by 30% in irradiated mice. In clinical investigation, pilot products inhibited the side-effects of cancer therapy including immune/hematopoietic depression. Therefore, the pilot products may be used as functional foods for overcoming of immune/hematopoietic depression and self-renewal tissue damages induced by irradiation, as well as for the immune/hematopoietic enhancement. Also we have screened food materials for inhibition of radiation-induced chronic damage (carcinogenesis), and selected effective 4 materials and elicited two mixture preparations with enhanced activity, and confirmed their inhibitory activities in cancer initiation model systems. To obtain the applicability of radiation technology for the safe sanitation and distribution of functional food materials, we verified the toxicological safety, stability of activity and active components of irradiated medicinal herbs. Also, screening of new radioprotective materials and basic biological research for the enhancement of

  11. Utility of DF-1 for Radioprotection in Lymphocytes

    Science.gov (United States)

    Reynolds, Julia; Casey, Rachael; Wu, Honglu; Huff, Janice; Emami, Kamal; Moore, Valerie; Jeevarajan, Antony

    2007-01-01

    The development of degenerative changes in the vasculature, such as atherosclerosis, is a known consequence of exposure to ionizing radiation, and is thus a concern for astronaut health following long duration space flight. Cellular damage caused by radiation is due to free radical generation and DNA damage. The goal of this project was to assess the ability of a C60-derivative, DF-1, to mitigate cellular damage resulting from radiation exposure in primary human lymphocytes. DF-1 is a water-soluble C60 fullerene encapsulated in dendrimeric functional groups that is proposed to exhibit antioxidant properties. Human lymphocytes are radiosensitive and travel throughout the body potentially causing bystander effects in any tissues they contact. These cells were subjected to varying doses of gamma radiation in the presence or absence of DF-1. Cells were collected at 48 hours post-irradiation for chromosomal aberration studies and at 72 hours post-irradiation for micronuclei studies. These studies showed that the irradiated cells contained more chromosomal aberrations and micronuclei than the control cells. Addition of the DF-1 reduced the amount of observed DNA damage in the irradiated cells. Growth curves were measured for the lymphocytes exposed to 0 and 4 Gray gamma irradiations, and we observed less growth in the cells irradiated at 4 Gy. 2,7-dichlorofluorescein diacetate was used to detect reactive oxygen species production, and increased production of ROS was observed in the irradiated lymphocytes. Human lymphocytes were subjected to varying doses of gamma or photon radiation in the presence and absence of DF-1 and a known radioprotectant, amifostine. After irradiation, the production of reactive oxygen species, growth curves and cell viability were measured. These cells were also collected to quantify chromosomal aberrations and micronuclei formation. We predict that irradiated cells will show the most damage and that DF-1 will provide protective effects similar

  12. Development of Functional Foods and Advanced Technology for Radioprotection

    International Nuclear Information System (INIS)

    We have previously developed two medicinal herb mixtures that protects immune/hematopoietic system and self-renewal tissues against irradiation and enhances immune/hematopoietic functions. In this study, we have developed two pilot products by adding the effective fractions to the hot water extract of the herb mixtures and investigated their efficacy. In irradiated mice, pilot products protected hematopoietic stem cells, promoted the regeneration and activation of immune cells, normalized the unbalanced immune reaction, and inhibited the growth of cancer cells. Polysaccharide was active fraction and mechanisms were elucidated. The products also protected the stem cells in self-renewal tissues. DNA/membrane damages, apoptotic cell signals, chromosome/DNA alterations, and oxidation of protein/lipid were inhibited by pilot products, and their radical scavenging activities were observed. Five active components were isolated and identified. Pilot products also inhibited the cancer development by 30% in irradiated mice. In clinical investigation, pilot products inhibited the side-effects of cancer therapy including immune/hematopoietic depression. Therefore, the pilot products may be used as functional foods for overcoming of immune/hematopoietic depression and self-renewal tissue damages induced by irradiation, as well as for the immune/hematopoietic enhancement. Also we have screened food materials for inhibition of radiation-induced chronic damage (carcinogenesis), and selected effective 4 materials and elicited two mixture preparations with enhanced activity, and confirmed their inhibitory activities in cancer initiation model systems. To obtain the applicability of radiation technology for the safe sanitation and distribution of functional food materials, we verified the toxicological safety, stability of activity and active components of irradiated medicinal herbs. Also, screening of new radioprotective materials and basic biological research for the enhancement of

  13. Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A

    OpenAIRE

    Arti Patel; Papiya Bigoniya; Chandra Shekhar Singh; Narayan Singh Patel

    2013-01-01

    Objectives: The present study was undertaken to evaluate the radioprotective and cytoprotective potential of cordifolioside-A, a primary active constituent of n-butanol fraction of Tinospora Cordifolia (NBTC) against 4 Gy-γ radiation in mice and cyclophosphamide induced genotoxicity. Materials and Methods: Presence of cordifolioside-A in NBTC stem ethanolic extract was confirmed by high performance thin layer chromatography (HPTLC) analysis. Radioprotective activity was evaluated at 80 an...

  14. The actual research of radioprotective education on the educational facilities for radiological technologists

    International Nuclear Information System (INIS)

    The aim of this study was to grasp the actual conditions of the radioprotective education in the educational facilities for radiological technologists, and to discuss the ideal way of radioprotective education toward the 21st century. For this purpose, we sent out the questionnaire concerning the circumstances of radioprotective education to 38 educational facilities for radiological technologists in Japan, including 6 universities, 15 junior colleges and 15 technical schools. This research was carried out on March, 1997, and the answers were obtained total 34 educational facilities (86.8%) (6 universities, 15 junior colleges and 13 technical schools) in total. Among the educational facilities in Japan, universities were much richer than the other two facilities in every respect on the educational circumstances including number and the quality of teaching staffs, educational institutions and equipment, practical training facilities and equipment, the number of collection of books in the library, etc. In the process of education for radiological technologists, the background to cause problems concerning the radioprotective education was largely dependent on the difference of educational schemes in Japan. From the view point of the elevation of educational standard for radiological technologists, it is better to transfer all educational processes to the universities, and give high and full level of radioprotective education in universities. And in the field of the medical radiology, the radioprotection and the management system should also be strengthened. For this purpose, it is also required to revise the related laws drastically, to strengthen lessons related to the radioprotection and to plan the richness in contents of the radioprotective education. (K.H.)

  15. The cytogenetic estimate of the radioprotective effect of antioxydant on normal and defected human cells

    International Nuclear Information System (INIS)

    In studying the radioprotective action of natural and synthesised antioxydants a decreased yield of chromosome aberrations with respect to those in untreated cells was noted in normal cells irradiated in phase G1 whereas no radioprotective effect was found in cells irradiated in G0. The addition of antioxydants into the cell cultures from patients with Turner's syndrome did not change their radiosensitivity. No adaptive response was induced in lymphocytes from patients with Down's syndrome cultivated with vitamine E

  16. Planetary Society

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    Carl Sagan, Bruce Murray and Louis Friedman founded the non-profit Planetary Society in 1979 to advance the exploration of the solar system and to continue the search for extraterrestrial life. The Society has its headquarters in Pasadena, California, but is international in scope, with 100 000 members worldwide, making it the largest space interest group in the world. The Society funds a var...

  17. Radioprotective effects of amifostine in vitro and in vivo measured with the comet assay

    International Nuclear Information System (INIS)

    Purpose: The authors investigated whether a potential radioprotective effect of amifostine (WR-2721) after in vitro or in vivo administration can be detected with the comet assay. Moreover, it was determined whether radioprotection by WR-2721 is dependent on the concentration of amifostine or alkaline phosphatase (AP, the enzyme which activates the prodrug). Furthermore, the authors tried to detect possible interindividual differences in radioprotection by amifostine. Material and methods: In vitro administration of amifostine: Freshly isolated lymphocytes from two healthy volunteers were incubated with different concentrations of AP (0-210 U/ml) and amifostine (0-5,000 μg/ml). In vivo administration of amifostine: Blood samples were collected from six postoperative rectal cancer patients before and after intravenous administration of amifostine 500 mg (no pretreatment with radio- or chemotherapy). Leukocytes and lymphocytes were irradiated and repaired in vitro and investigated with the alkaline comet assay. The radioprotective effect was evaluated by calculating dose-modifying factors (DMFs) and the paired t-test. Results: Amifostine alone did not alter the radiation-induced DNA damage in vitro. The addition of at least 0.5-1 U/ml AP was required. A significant radioprotective effect (p<0.05) was seen after administration of amifostine in vitro for all concentrations investigated (250-5,000 μg/ml, initial DNA damage). A comparable radioprotective effect after in vivo administration of 500 mg amifostine was measured with a mean DMF of 0.87. Interindividual differences were present in vivo and in vitro. Conclusion: Amifostine 500 mg intravenously yields an adequate radioprotective concentration. The effect was only marginally improved by extreme concentrations of amifostine in vitro experiments. The comet assay is capable of detecting small changes in radiosensitivity by amifostine. (orig.)

  18. Radioprotective effects of amifostine in vitro and in vivo measured with the comet assay

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, A.-C.; Pigorsch, S.; Dunst, J. [Martin Luther University of Halle-Wittenberg, Halle (Germany). Department of Radiotherapy; Beyer, C. [Martin Luther University of Halle-Wittenberg, Halle (Germany). Institute of Clinical Chemistry and Pathobiochemistry; Lautenschlaeger, C. [Martin Luther University of Halle-Wittenberg, Halle (Germany). Institute of Biomathematics

    2004-08-01

    Purpose: The authors investigated whether a potential radioprotective effect of amifostine (WR-2721) after in vitro or in vivo administration can be detected with the comet assay. Moreover, it was determined whether radioprotection by WR-2721 is dependent on the concentration of amifostine or alkaline phosphatase (AP, the enzyme which activates the prodrug). Furthermore, the authors tried to detect possible interindividual differences in radioprotection by amifostine. Material and methods: In vitro administration of amifostine: Freshly isolated lymphocytes from two healthy volunteers were incubated with different concentrations of AP (0-210 U/ml) and amifostine (0-5,000 {mu}g/ml). In vivo administration of amifostine: Blood samples were collected from six postoperative rectal cancer patients before and after intravenous administration of amifostine 500 mg (no pretreatment with radio- or chemotherapy). Leukocytes and lymphocytes were irradiated and repaired in vitro and investigated with the alkaline comet assay. The radioprotective effect was evaluated by calculating dose-modifying factors (DMFs) and the paired t-test. Results: Amifostine alone did not alter the radiation-induced DNA damage in vitro. The addition of at least 0.5-1 U/ml AP was required. A significant radioprotective effect (p<0.05) was seen after administration of amifostine in vitro for all concentrations investigated (250-5,000 {mu}g/ml, initial DNA damage). A comparable radioprotective effect after in vivo administration of 500 mg amifostine was measured with a mean DMF of 0.87. Interindividual differences were present in vivo and in vitro. Conclusion: Amifostine 500 mg intravenously yields an adequate radioprotective concentration. The effect was only marginally improved by extreme concentrations of amifostine in vitro experiments. The comet assay is capable of detecting small changes in radiosensitivity by amifostine. (orig.)

  19. Operational measurements in radioprotection in the industrial and medical environments

    International Nuclear Information System (INIS)

    This document gathers the slides of the available presentations given during these conference days. Thirty presentations are assembled in the document and deal with: 1 - enforcement circular of the labor code dispositions relative to workers protection against ionizing radiation hazards (T. Lahaye); 2 - context and regulatory evolutions - public health code (S. Rodde); 3 - references and perspectives in external dosimetry (J.M. Bordy); 4 - CIPR's Committee 2 works (F. Paquet); 5 - from protection data to measurement data (A. Pin); 6 - dosimetric control in radiotherapy (A. Veres); 7 - calibration of irradiation measurement devices in industrial environment (A. Cadiou); 8 - calibration and verification of nuclear measurement devices (J.Y. Branthonne); 9 - calibration of measurement devices in medical environment (J.M. Bordy); 10 - quality control in radiotherapy (A. Batalla); 11 - in-vivo dosimetry in radiotherapy (A. Noel); 12 - calibration metrology of fixed post irradiation sensors (L. Laloubere); 13 - design requirements for the radiological zoning and the wastes cleanliness of Flamanville 3 EPR reactor (S. Moreau); 14 - efficiency of aerosol capture systems used in CNPE EDF (F. Gensdarmes); 15 - mobile surveillance means of the atmospheric contamination of CNPE EDF's reactor building (S. Marques and M. Lestang); 16 - experience feedback about the security gates at EDF's nuclear facilities (N. Valendru); 17 - metrology needs for radioprotection technical controls (P. Tranchant); 18 - technical evaluation of a flowmeter/dosemeter in the framework of the regulatory control of X-ray electric generators used in radio-diagnosis (P. Martel); 19 - reinforced natural radioactivity - the case of radon measurement (S. Bernhard); 20 - fires during radioactive materials transport (P. Chareyre); 21 - measurement in the framework of medical examinations: radiology service (A. Noel); 22 - operational measurements in nuclear medicine (I. Gardin); 23 - from the operational

  20. Detection of Argentine onions treated with 60 Co irradiation

    International Nuclear Information System (INIS)

    Brazil has been the most important MERCOSUL's purchaser of fresh onions from Argentina. The increased claim for this fresh product has forced a consensus between the members nations, as regards to phytosanitary restrictions. The radio inhibition is described on National Food Codes in Brazil and Argentina. Methods of food irradiation detection must be performed, since they increase the consumer confidence. Quick and simple screening tests indicate whether a food product has been irradiated or not. This present study verified the DNA fragments of argentine fresh onions, produced during radiation process and 6 months of storage period. The DNA fragments are analyzed for detection of irradiated foods. The irradiated onions presented extensive DNA migrations, as comets, when submitted to agarose gel electrophoresis. They also showed more shelf life compared to the unirradiated onions. The unirradiated samples exhibited only limited DNA migration. This initial screen method showed to be effective for detection of irradiated onions. (author)

  1. Characterization of Argentine Loess and Paleosols by Moessbauer Spectroscopy

    International Nuclear Information System (INIS)

    We have used Moessbauer spectroscopy to investigate iron-bearing mineral samples of loess and paleosols from a geologic section at La Plata, Argentina, 34 deg. 54' 14'' S and 58 deg. 2' W. Hematite is by far the dominant iron-bearing magnetic component in initial loess and paleosol samples. The samples were also subjected to magnetic separation. The magnetically enriched loess fractions show a remarkable increase in the content of magnetite. The enhancement of non-magnetic Fe3+ and a decrease of Fe2+ mineral phases in the paleosol layer seem to be a consequence of the process of pedogenesis which also caused a dissolution of magnetic iron oxides by weathering. The increase of magnetite in the silt fraction suggests that the wind could have been the main carrier of magnetic minerals, causing the major differences in the magnetic parameters between loess and paleosols in the Argentine loess plateau

  2. Knowledge management in the Argentine Nuclear Regulatory Authority

    International Nuclear Information System (INIS)

    In 2006, the Argentine Nuclear Regulatory Authority has initiated a regulatory knowledge management process to face the loss of knowledge resulting from retiring experts, the generation gap, and the existing need to train new human resources. A number of projects have been started together with the technical assistance of the National Public Administration Institute to preserve knowledge and render it explicit for the coming generations. These projects include 'The History of the Expert's Learning Process' in which the majority of the most critical experts have been interviewed so far. The results of this project help envision a training structure and prospective projects. An Internet Site has also been created on the Intranet in order to render knowledge explicit and facilitate the tools for knowledge management initiatives. Furthermore, ARN's knowledge map project has also been started. (author)

  3. Native supercolonies of unrelated individuals in the invasive Argentine ant

    DEFF Research Database (Denmark)

    Pedersen, Jes Søe; Krieger, Michael J. B.; Vogel, Valérie;

    2006-01-01

    Kinship among group members has long been recognized as a main factor promoting the evolution of sociality and reproductive altruism, yet some ants have an extraordinary social organization, called unicoloniality, whereby individuals mix freely among physically separated nests. This type of social...... organization is not only a key attribute responsible for the ecological dominance of these ants, but also an evolutionary paradox because relatedness between nestmates is effectively zero. Recently, it has been proposed that, in the Argentine ant, unicoloniality is a derived trait that evolved after its...... introduction into new habitats. Here we test this basic assumption by conducting a detailed genetic analysis of four native and six introduced populations with five to 15 microsatellite loci and one mitochondrial gene. In contrast to the assumption that native populations consist of family-based colonies with...

  4. Annual Report ABACC 2003 - Brazilian-Argentine Agency for the Accounting and Control of Nuclear Materials

    International Nuclear Information System (INIS)

    This Report describes the actions of the Brazil-Argentine of Accounting and Control of Nuclear Materials (ABACC), during the year of 2003. The developed work allowed to concluded that there is no event indicating that any nuclear material non-accounted for were deviated for non permitted activities by the Agreement for Peaceful Use of Nuclear Energy between Argentine and Brazil and by the Four Parties Agreement among these countries, the ABACC and the International Atomic Energy Agency (IAEA)

  5. Networks in Argentine agriculture: a multiple-case study approach

    Directory of Open Access Journals (Sweden)

    Sebastián Senesi

    2013-06-01

    Full Text Available Argentina is among the four largest producers of soybeans, sunflower, corn, and wheat, among other agricultural products. Institutional and policy changes during the 1990s fostered the development of Argentine agriculture and the introduction of innovative process and product technologies (no-till, agrochemicals, GMO, GPS and new investments in modern, large-scale sunflower and soybean processing plants. In addition to technological changes, a "quiet revolution" occurred in the way agricultural production was carried out and organized: from self-production or ownership agriculture to a contract-based agriculture. The objective of this paper is to explore and describe the emergence of networks in the Argentine crop production sector. The paper presents and describes four cases that currently represent about 50% of total grain and oilseed production in Argentina: "informal hybrid form", "agricultural trust fund", "investor-oriented corporate structure", and "network of networks". In all cases, hybrid forms involve a group of actors linked by common objectives, mainly to gain scale, share resources, and improve the profitability of the business. Informal contracts seem to be the most common way of organizing the agriculture process, but using short-term contracts and sequential interfirm collaboration. Networks of networks involve long-term relationships and social development, and reciprocal interfirm collaboration. Agricultural trust fund and investor-oriented corporate structures have combined interfirm collaboration and medium-term relationships. These organizational forms are highly flexible and show a great capacity to adapt to challenges; they are competitive because they enjoy aligned incentives, flexibility, and adaptability.

  6. Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

    Energy Technology Data Exchange (ETDEWEB)

    Sebastia, Natividad, E-mail: natividad.sebastia@uv.es [Area de Nutricion y Bromatologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot (Spain); Montoro, Alegria [Servicio de Proteccion Radiologica, Hospital Universitario La Fe, 46009, Valencia (Spain); Montoro, Amparo [Area de Nutricion y Bromatologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot (Spain); Almonacid, Miguel; Villaescusa, Juan Ignacio [Servicio de Proteccion Radiologica, Hospital Universitario La Fe, 46009, Valencia (Spain); Cervera, Jose; Such, Esperanza; Silla, Ma Angeles [Servicio de Hematologia, Hospital Universitario La Fe, 46009, Valencia (Spain); Soriano, Jose Miguel [Area de Nutricion y Bromatologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot (Spain)

    2011-09-15

    Many natural substances have been studied in recent past to be used as radioprotectors to mitigate ionizing radiation-induced damage in mammalian systems due to its effectiveness given both pre- and post-irradiation and for long time with out drug-related toxicity. Curcumin and trans-resveratrol are both natural occurring polyphenols, obtained from the root of Curcuma longa and from grapes and other berries, respectively. These compounds have shown antioxidant, anti-inflammatory, immunostimulant and anti-carcinogenic properties. Our aim was to evaluate the radioprotective efficacy, in vitro, of curcumin and trans-resveratrol separately against radiation-induced chromosomal aberrations. The study was carried out by the pre-treatment of human blood lymphocytes at concentrations from 0 to 500 {mu}g mL{sup -1} and from 0 to 50 {mu}g mL{sup -1} for curcumin and trans-resveratrol, respectively. The results showed that all concentrations tested reduced radiation-induced chromosomal damage. Maximum damage protection was observed at the concentration of 5 {mu}g mL{sup -1} for curcumin and 0.5 {mu}g mL{sup -1} for trans-resveratrol. Thus, our results show that curcumin and trans-resveratrol pre-treatment significantly protect normal lymphocytes against {gamma}-radiation-induced cellular damage.

  7. Radioprotective and Immunostimulating Effects of Deuterium-Depleted Water

    International Nuclear Information System (INIS)

    Full text: Mice fed during 15 days with Deuterium-Depleted Water (30 ppm deuterium) had a statistically significant increased survival compared with control groups fed with normal distilled water (150 ppm deuterium) after 8.5 Gy irradiation (61% survival in test group towards 25% in control group). Hematological picture showed maintaining of the normal WBC, RBC and platelet count in test groups. Immunological parameters (serum opsonic and bactericidal capacity, bactericidal capacity of the peritoneal macrophages) showed a marked increase in test groups compared to a severe decrease in the control groups. Auxiliary tests using chemical radiomimetics (hydrochloric embihine) and immunosupressors (cyclophosphamide) showed a strong protective effect of deuterium-depleted water against the decrease of the leukocyte counts and other immunologic parameters. In conditions of experimental inflammation with subcutaneous-implanted pellets, deuterium-depleted water feeding statistically significant increased inflammatory response, obviated by increased percentages of PMN and lymphocytes in the peripheral blood and increased phagocytic capacity of the peripheral blood PMN. Experimental infections with K. pneumoniae 506 and S. pneumoniae 558 in mice irradiated or treated with cyclophosphamide showed increased non-specific immunity parameters. All results show a marked intensification of the immune defenses and increased proliferation of the peripheral blood cells, probably accounting for the radioprotective effects. (author)

  8. Radioprotection of Swiss albino mice by Myristica fragrans houtt

    International Nuclear Information System (INIS)

    Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties. Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded lethal dose to 50% of the population in 30 days (LD50/30) as 6.83 Gy and 8.89 Gy for irradiated only and (MF+radiation) groups, respectively. The dose reduction factor was computed as 1.3. Administration of MF significantly enhanced hepatic glutathione (GSH) and decreased testicular lipid peroxidation (LPO) level whereas acid phosphatase (ACP) and alkaline phosphatase (ALP) activity did not show any significant alteration. Irradiation resulted in significant elevation in LPO level and ACP activity, and decreased the GSH content and ALP activity. MF pretreatment effectively protected against radiation induced biochemical alteration as reflected by a decrease in LPO level and ACP activity, and an increase in GSH and ALP activity. The present study has implications for the potential use of MF as a radioprotector. (author)

  9. The radioprotective effect of human lactoferrin in mice

    International Nuclear Information System (INIS)

    Objective: To study the effect of human lactoferrin on the X-ray Radiation Injury in mice. Methods: The mice were randomly divided into three groups: control group, radiation group and lactoferrin group. To give mice 6.8 Gy, observe mice' 30 d survival rate and to give mice 2 Gy, observe bone marrow micronucleus, nuclear cell count. Results: All the mice of radiation group without Lactoferrin died in 25 d after exposure. The group the 30-day livability is high, there was a significant difference in comparison between radiation group without lactoferrin and groups with lactoferrin (P<0.05). In the group without lactoferrin, the bone marrow karyocytes decreased significantly after radiation, and the treatment groups (including prevention and emergency) are higher than pure radiation group, there was a significant difference in comparison between radiation group without lactoferrin and groups with lactoferrin (P<0.05). Simply after radiation for 3 days, mice micronucleus bone marrow cells showed a significantly higher rate, and the group without lactoferrin, it showed less than the group with lactoferrin, with significant difference (P<0.05). Conclusion: Lactoferrin which is used in the prevention iron or emergency to has radioprotective effect. (authors)

  10. Radioprotective Effect Of Green Tea Extract On GAMMA Irradiated Mice

    International Nuclear Information System (INIS)

    This study aimed to evaluate the possible radioprotective role of green tea extract (GTE) in mice exposed to gamma radiation. Eighty male mice were divided into four groups; group (A) was considered the control, group (B) received 1.5% GTE for 14 days, group (C) exposed to 4 Gy gamma radiation and group (D) received GTE and exposed to 4 Gy gamma radiation. Blood and liver tissue were collected from these groups 24 hours, 3 days and 5 days post-irradiation to measure the levels of hepatic malondialdehyde (MDA) and superoxide dismutase (SOD), serum aminotransferases (ALT and AST), Hb concentration, RBCs, WBCs and platelets counts, in addition to ultra-structure examination of the liver. The results revealed that GTE supplementation prior to irradiation significantly decreased hepatic MDA, increased hepatic antioxidant enzyme (SOD) and decreased serum ALT and AST compared to irradiated mice. Also, supplementation of mice with GTE led to regeneration and protection of hepatocytes and the levels of the hematological parameters were significantly increased in the GTE pre-treated group as compared to irradiated animals. It could be conclude that the GTE may be a good agent to attenuate radiation-induced damage to the liver and hematopoietic system.

  11. Normal tissue radioprotection by amifostine via Warburg-type effects

    Science.gov (United States)

    Koukourakis, Michael I.; Giatromanolaki, Alexandra; Zois, Christos E.; Kalamida, Dimitra; Pouliliou, Stamatia; Karagounis, Ilias V.; Yeh, Tzu-Lan; Abboud, Martine I.; Claridge, Timothy D. W.; Schofield, Christopher J.; Sivridis, Efthimios; Simopoulos, Costantinos; Tokmakidis, Savvas P.; Harris, Adrian L.

    2016-01-01

    The mechanism of Amifostine (WR-2721) mediated radioprotection is poorly understood. The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. Indirect calorimetric canopy tests showed significant reductions in oxygen consumption and of carbon dioxide emission in cancer patients receiving amifostine. Glucose levels significantly decreased and lactate levels increased in patient venous blood. Although amifostine in vitro did not inhibit the activity of the prolyl-hydroxylase PHD2, experiments with mouse liver showed that on a short timescale WR-1065 induced expression of the Hypoxia Inducible Factor HIF1α, lactate dehydrogenase LDH5, glucose transporter GLUT2, phosphorylated pyruvate dehydrogenase pPDH and PDH-kinase. This effect was confirmed on normal mouse NCTC hepatocytes, but not on hepatoma cells. A sharp reduction of acetyl-CoA and ATP levels in NCTC cells indicated reduced mitochondrial usage of pyruvate. Transient changes of mitochondrial membrane potential and reactive oxygen species ROS production were evident. Amifostine selectively protects NCTC cells against radiation, whilst HepG2 neoplastic cells are sensitized. The radiation protection was correlates with HIF levels. These findings shed new light on the mechanism of amifostine cytoprotection and encourage clinical research with this agent for the treatment of primary and metastatic liver cancer. PMID:27507219

  12. Study on induction of radioprotection using antioxidant combinations

    Energy Technology Data Exchange (ETDEWEB)

    Lim, J. S.; Choe, Y. K.; Lee, H. G.; Kim, K. D. [Korea Research Institute of Bioscience and Biotechnology, Taejeon (Korea)

    2000-04-01

    Antioxidants are applied in tumor patients during chemo- or radiotherapy due to its cytoprotective effects. Therefore, aim of our study was to evaluate the effect of exposure with a variety of antioxidants on primary bone marrow cells after {gamma}-irradiation. We studied the radiation-induced cell death in comparison to mouse bone marrow cells after single-dose irradiation with 1, 2, 3 or 6 Gy and controls without irradiation. Cells cultured in vitro had been exposed to different concentrations of antioxidants prior to {gamma}-irradiation. The effect was evaluated 6, 8, 17 or 24 h after radiation exposure by propium iodide staining. While sodium selenite and N-acetylcyseine could achieve significant inhibition of radiation-induced cell death, aminoguanidine and alpha-lipoic acid were not shown to inhibit it. Furthermore, the combination of N-acetylcysteine with some mild antioxidants such as BHA, propyl gallate, quercetin or trolox induced the significant inhibition of radiation-induced cell death. However, these effect was different depending on the duration of radiation exposure and the concentration of antioxidants added in culture. Although the radioprotective effect of antioxidants should be compared with the effect on tumor itself, our results indicate that the use of antioxidants in combination can efficiently modulate the radiation-induced cell damage like apoptosis and can be applied in tumor patients during radiotherapy. 26 refs., 7 figs., 7 tabs. (Author)

  13. Normal tissue radioprotection by amifostine via Warburg-type effects.

    Science.gov (United States)

    Koukourakis, Michael I; Giatromanolaki, Alexandra; Zois, Christos E; Kalamida, Dimitra; Pouliliou, Stamatia; Karagounis, Ilias V; Yeh, Tzu-Lan; Abboud, Martine I; Claridge, Timothy D W; Schofield, Christopher J; Sivridis, Efthimios; Simopoulos, Costantinos; Tokmakidis, Savvas P; Harris, Adrian L

    2016-01-01

    The mechanism of Amifostine (WR-2721) mediated radioprotection is poorly understood. The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. Indirect calorimetric canopy tests showed significant reductions in oxygen consumption and of carbon dioxide emission in cancer patients receiving amifostine. Glucose levels significantly decreased and lactate levels increased in patient venous blood. Although amifostine in vitro did not inhibit the activity of the prolyl-hydroxylase PHD2, experiments with mouse liver showed that on a short timescale WR-1065 induced expression of the Hypoxia Inducible Factor HIF1α, lactate dehydrogenase LDH5, glucose transporter GLUT2, phosphorylated pyruvate dehydrogenase pPDH and PDH-kinase. This effect was confirmed on normal mouse NCTC hepatocytes, but not on hepatoma cells. A sharp reduction of acetyl-CoA and ATP levels in NCTC cells indicated reduced mitochondrial usage of pyruvate. Transient changes of mitochondrial membrane potential and reactive oxygen species ROS production were evident. Amifostine selectively protects NCTC cells against radiation, whilst HepG2 neoplastic cells are sensitized. The radiation protection was correlates with HIF levels. These findings shed new light on the mechanism of amifostine cytoprotection and encourage clinical research with this agent for the treatment of primary and metastatic liver cancer. PMID:27507219

  14. Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

    International Nuclear Information System (INIS)

    Many natural substances have been studied in recent past to be used as radioprotectors to mitigate ionizing radiation-induced damage in mammalian systems due to its effectiveness given both pre- and post-irradiation and for long time with out drug-related toxicity. Curcumin and trans-resveratrol are both natural occurring polyphenols, obtained from the root of Curcuma longa and from grapes and other berries, respectively. These compounds have shown antioxidant, anti-inflammatory, immunostimulant and anti-carcinogenic properties. Our aim was to evaluate the radioprotective efficacy, in vitro, of curcumin and trans-resveratrol separately against radiation-induced chromosomal aberrations. The study was carried out by the pre-treatment of human blood lymphocytes at concentrations from 0 to 500 μg mL-1 and from 0 to 50 μg mL-1 for curcumin and trans-resveratrol, respectively. The results showed that all concentrations tested reduced radiation-induced chromosomal damage. Maximum damage protection was observed at the concentration of 5 μg mL-1 for curcumin and 0.5 μg mL-1 for trans-resveratrol. Thus, our results show that curcumin and trans-resveratrol pre-treatment significantly protect normal lymphocytes against γ-radiation-induced cellular damage.

  15. Radioprotective effect of genistein on hematopoietic system of mice

    International Nuclear Information System (INIS)

    Objective: To study the radioprotective effect of genistein on mice hematopoietic system. Methods: Adult male BALB/c mice were administered orally with genistein 24 h before exposure to a sublethal dose of 6.0 Gy gamma irradiation. The 30-day survival rate and some indices with relation to hematogenesis were examined after irradiation and pathologic changes of bone marrow were detected by hematotoxylin-eosin staining. Results: Bone marrow was damaged slightly, and the numbers of peripheral blood WBC, bone marrow nucleated cells and CFU-S were all significantly higher and restored more rapidly in genistein-treated groups than those in the corresponding irradiated controls (P<0.05). Meanwhile, genistein could also increase the 30-days survival rate and the average survival days of dead mice (P<0.05). All results were similar to those in diethylstilbestrol-treated groups. In addition, genistein could promote recovery of spleen/body weight ratio (P<0.05). Conclusion: These observations suggest that genistein has the capability of reducing the damage of hematopoietic system in irradiated mice and has significant protective effect on mice against radiation injury. (authors)

  16. Biochemical and molecular genetic approaches on the radioprotective mechanism of natural products

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Hee; Lee, Eun Ju; Sung, Woo Kyung; Piao, Wen Hua [Kyunghee University, Seoul (Korea)

    1999-04-01

    We reported the radio-protective effect of DTT. The treatment of DTT increased cell survival after gamma-irradiation, decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after UV-C irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. About 100 medicinal plants were purchased and methanol extract samples were prepared. Radio-protective and radio-sensitizing activities of these samples were screened. Seven samples showed above 20% radio-protective activities: Salvia miltiorrhiza, Areca catechu, Cornus officinalis, Alpiniae officinari rhizoma, Meliae fructus, Alpiniae katsumadaii semen, Betulae cortex. Acanthopanax sessiliflous showed the highest radio-sensitizing effect and 10 other samples revealed moderate activities: Melia japonica, Agastache rugosa, Platycodon gradiflorum, Broussonetia bazinoki, Angelica gigas, Inula helenium, Chelidonium majus, Pulsatilla koreana, Oldenlandia diffusa, Dioscorea batatas. (author). 49 refs., 9 figs., 7 tabs.

  17. Radioprotective effects of a preparation (HemoHIM) of a herb mixture

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Sung Kee; Park, Hae Ran; Jung, U Hee; Jeong, Ill Yun; Byun, Myung Woo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Kim, Sung Ho [Chonnam National University, Kwangju (Korea, Republic of); Yee, Sung Tae [Sunchon National University, Sunchon (Korea, Republic of)

    2004-07-01

    The proliferation of radioactive materials in industry, medicine, scientific and medical research, the military, and as a source of energy has increased the likelihood of an accidental exposure to ionizing radiation. Synthetic radioprotective agents have been studied for decades but their application was limited due to their toxicity. Thus, the radioprotective agent to protect individuals against severe radiation damage is required. A preparation (HemoHIM) of a mixture of 3 edible herbs was designed to protect the gastrointestine and hematopoietic organs and to promote recovery of the immune system against radiation damage. In this study, we evaluated its radioprotective effects with regards to reduction of DNA damage, immune cell repopulation, intestinal crypt survival, and 30-day survival rate.

  18. Use of micronucleus test in evaluating radioprotective action of mixed tremella preparation

    International Nuclear Information System (INIS)

    The radioprotective action of mixed tremella preparation (Yinshen Yin) on whole body gamma irradiated dogs has been studied. 25 male dogs were divided into five groups: tremella, mercaminum, Yinshen Yin at high dose, Yinshen Yin at low dose and control. All the dogs were given above drugs in 10 successive days before acute exposure of 1 Gy radiation. The results showed that the prophylactic use of Yinshen Yin had good anti-irradiation effect, and the radioprotective effect was similar to the mercaminum, but significantly higher than tremella. Thereby it was considered as a good radioprotective agent. The dose reduction factor in different groups were: Yinshen Yin high dose 2.01, Yinshen Yin low dose group 1.72, mercaminum group 1.55 and tremella group 1.11

  19. Radioprotection of C3H mice by recombinant human interleukin-1α

    International Nuclear Information System (INIS)

    High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radio-protection at the optimum times was also observed in the cell kinetic behaviour of GM-CFC in the bone marrow. In previous studies it was reported that less radioprotection was found in C3H/HeN mice pretreated with IL-1. This may not be the case with a higher dose of IL-1. (author)

  20. Current knowledge from experimental works with radioprotective drugs from the viewpoint of latest scientific research

    International Nuclear Information System (INIS)

    The protection of both human and animal population against a radiation impairment proves to be an impulse for continuous intensive searching for plants with radioprotective properties, identification of their radioprotective components and examination of their effects both in vivo an in vitro. I am presenting the results as well as knowledge of a latest scientific research in this field with testing the following plants: Vigna radiata, Mentha piperita, Citrus aurantium var. amara, Syzygium cumini, Tinospora cordifolia, Aegle marmelos, Phyllanthus amarus, Aloe vera, Angelica sinensis, Rosemarinus officinalis, Panax ginseng, Hippophae rhamnoides, Ocimum sanctum, Crataegus microphylla. (authors)

  1. Cosmic radiation dosimetry in international flights argentine airlines

    International Nuclear Information System (INIS)

    Full text: Introduction: In commercial aviation the most important determinants of radiation exposure in humans are the altitude, latitude, flight duration and the solar cycle's period. This study was conducted to address this type of exposure trough radiation dosimetry. Method: The study was performed in the business-class cabin of an Airbus 340-200 aircraft, provided by Argentine Airlines, during 2 flights routes: New York-Miami-Buenos Aires (trans equatorial) and Buenos Aires-Auckland (circumpolar). Measurements addressed the electromagnetic spectrum or low Linear Energy Transfer (LET) and corpuscular radiation (High LET). The instruments used were an Ion Chamber (IC), to measure the ionizing component of radiation (i.e., gamma radiation), the SWENDI, to measure only the neutron component, and the Tissue Equivalent Proportional Counter (TEPC) for measuring all radiation types. Results: The routes' dose rates are presented in the table. TEPC rates agreed with the LET findings. The total dose rates of high latitude flights were higher than those of low latitude flights. The SWENDI (High LET) results for the flights over the equator, at low latitude, represented only 1/3 of the total radiation. The New York-Miami and Buenos Aires-Auckland flights, at high latitude, represented just under 1/2 of the Total radiation (-45%). Conclusion: Based on the results of this study, the annual dose rates of radiation exposure of air crew personnel serving on international flights offered by Argentine Airlines is between 3 and 7 mSv. This rate is higher than the maximum recommended for the general population by the International Commission on Radiological Protection (ICRP), which is 1 milli Sv./y. Therefore, these personnel must be officially considered 'Occupationally Exposed to Radiation' in way to provide the appropriate measures that must be implemented for their protection in accordance to ICRP guidelines. Dose(uSv): Route N Y-Miami, IC 6.07, SWENDI 5.07, TEPC 11.04; Route

  2. Latin American and Caribbean Federation of Radiation Protection Societies (FRALC)

    International Nuclear Information System (INIS)

    The idea of a Federation of Radiation Protection Societies in Latin America came up at the First Regional Congress on Radiation Protection and Nuclear Safety that was held in Buenos Aires (Argentina), in October 1991. At the Second Regional Congress, in Zacatecas (Mexico), in 1993, the Latin American and Caribbean Federation of Radiation Protection Societies (FRALC) was officially launched. The founder members were the Argentine Radiation Protection Society (SAR), the Brazilian Radiation Protection Society (SBPR), the Mexican Radiation Safety Society (SMSR) and the Peruvian Radiation Protection Society (SPR). Now, the FRALC has accepted as members the Radiation Protection Section of the Cuban Physics Society (SPRC) and the Uruguayan Radiation Protection Association (AUR). The basic objectives of the FRALC are: to promote the safe use of radiation and radioactive sources in Latin America and the Caribbean; to promote the foundation of new Radiation Protection Societies within the region, as mean of associating radiation protection professionals, and then, to promote of affiliation of this new societies to IRPA; to encourage the cooperation and mutual aid in the study, research and use of resources, in order to promote the radiation protection development in Latin America and the Caribbean

  3. Insecticide transfer efficiency and lethal load in Argentine ants

    Science.gov (United States)

    Hooper-Bui, L. M.; Kwok, E. S. C.; Buchholz, B. A.; Rust, M. K.; Eastmond, D. A.; Vogel, J. S.

    2015-10-01

    Trophallaxis between individual worker ants and the toxicant load in dead and live Argentine ants (Linepithema humile) in colonies exposed to fipronil and hydramethylnon experimental baits were examined using accelerator mass spectrometry (AMS). About 50% of the content of the crop containing trace levels of 14C-sucrose, 14C-hydramethylnon, and 14C-fipronil was shared between single donor and recipient ants. Dead workers and queens contained significantly more hydramethylnon (122.7 and 22.4 amol/μg ant, respectively) than did live workers and queens (96.3 and 10.4 amol/μg ant, respectively). Dead workers had significantly more fipronil (420.3 amol/μg ant) than did live workers (208.5 amol/μg ant), but dead and live queens had equal fipronil levels (59.5 and 54.3 amol/μg ant, respectively). The distribution of fipronil differed within the bodies of dead and live queens; the highest amounts of fipronil were recovered in the thorax of dead queens whereas live queens had the highest levels in the head. Resurgence of polygynous ant colonies treated with hydramethylnon baits may be explained by queen survival resulting from sublethal doses due to a slowing of trophallaxis throughout the colony. Bait strategies and dose levels for controlling insect pests need to be based on the specific toxicant properties and trophic strategies for targeting the entire colony.

  4. Nuclear trade: an approach on the Argentine situation

    International Nuclear Information System (INIS)

    The Argentine nuclear trade regime. Nuclear Materials. Definitions. Stages. From early times of nuclear development an actual and strict monopoly governed the transfers of nuclear materials. That meant: the Federal State took the control as user, producer, purchaser or seller. This policy was inspired and clearly echoed a similar one developed by countries with important development in the nuclear field. Types of contracts on nuclear commerce. Relation with costs implied with the nuclear industry. Uranium mining. System of supplies. Development of factories of nuclear supplies. Incentives. Nuclear Power. Radioisotopes. Human Resources. Ways of intervention of the State on nuclear Commerce. The right of veto. The ownership of shares in private or public corporations. Export- import controls. Security and Safety standards. National Act of Nuclear Activity. Veto of the Executive Power to the monopoly of the exclusive national supply of uranium. Comparative policies on other fields or products in Argentina. A proposal of lege ferenda. State's right of transformation applicable to purchases and sales of nuclear materials. Exchange and loans. Cosignature of contracts, etc. (author)

  5. Argentine regulatory experience concerning radiation protection in industrial gammagraphy

    International Nuclear Information System (INIS)

    Industrial gammagraphy has always been responsible for the highest rates of radiological incidents in almost every part of the world. This is mainly due to the high activities of the radioactive sources used, which are constantly transported in the equipment that contains them between the storage and the areas of work, and is also due to workload pressures which may induce to negligence in following the operational procedures, if a strong Safety Culture does not exist. The purpose of this paper is to present the main aspects of the Argentine Regulations relating to radiation protection to control this practice and to contribute in this way to reduce the associated risks. In addition, some incidents occurred in Argentina during the latest years, the causes that led to those events and their relation to the in observance of the regulations in force, their consequences and the measures taken to repair them are described. Finally, the importance of the role that education and training has in the strengthening of Safety Culture, key element of all undertaking, is highlighted. (author)

  6. Active tectonics in the Argentine Precordillera and Western Sierras Pampeanas

    Directory of Open Access Journals (Sweden)

    L.L. Siame

    2006-12-01

    Full Text Available The Andean foreland of western Argentina (28°S-33°S corresponds to retroarc deformations associated with the ongoing flat subduction of the Nazca plate beneath the South American lithosphere. This region is characterized by high levels of seismic activity and crustal active faulting. To improve earthquake source identification and characterization in the San Juan region, data from seismology, structural geology and quantitative geomorphology were integrated and combined to provide a seismotectonic model. In this seismotectonic model, the Andean back-arc of western Argentina can be regarded as an obliquely converging foreland where Plio-Quaternary deformations are partitioned between strike-slip and thrust motions that are localized on the E-verging, thin-skinned Argentine Precordillera, and the W-verging thick-skinned Sierras Pampeanas, respectively. In this seismotectonic model, the Sierra Pie de Palo appears to be a key structure playing a major role in the partitioning of the Plio-Quaternary deformations.

  7. [Distribution of Lutzomyia longipalpis in the Argentine Mesopotamia, 2010].

    Science.gov (United States)

    Salomon, Oscar D; Fernandez, Maria S; Santini, María S; Saavedra, Silvina; Montiel, Natalia; Ramos, Marina A; Rosa, Juan R; Szelag, Enrique A; Martinez, Mariela F

    2011-01-01

    The first case of visceral leishmaniasis (VL) in Argentina was reported in 2006 in Posadas, Misiones. During the summer 2008-2009 Lutzomyia longipalpis, the VL vector, and canine VL cases were already spread along the province of Corrientes. In order to know the distribution of VL risk, systematic captures of the vector were performed between February and March 2010, in 18 areas of the provinces of Entre Ríos and Corrientes, and the city of Puerto Iguazú, Misiones, with a total of 313 traps/night. We confirmed the presence of Lu. longipalpis, for the first time in Chajarí (Entre Ríos), Alvear, La Cruz, Curuzú Cuatiá and Bella Vista (Corrientes), and Puerto Iguazú (Misiones). In Santo Tome and Monte Caseros (Corrientes), where the vector had been previously reported, traps with more samples were obtained with 830 and 126 Lu. Longipalpis trap/site/night respectively. These results show that the vector of urban VL continues spreading in the Argentine territory. Simultaneously, the spread of the parasite and the resulting human VL cases are associated with the dispersion of reservoirs, infected dogs, with or without clinical symptoms or signs, due to human transit. PMID:21296716

  8. Fragile-X mental retardation: molecular diagnosis in Argentine patients.

    Science.gov (United States)

    Florencia, Giliberto; Irene, Szijan; Veronica, Ferreiro

    2006-11-30

    Fragile-X-syndrome (FXS) is the most common type of inherited cognitive impairment. The underlying molecular alteration consists of a CGG-repeat amplification within the FMR-1 gene. The phenotype is only apparent once a threshold in the number of repeats has been exceeded (full mutation). The aim of this study was to characterize the FMR-1 CGG-repeat status in Argentine patients exhibiting mental retardation. A total of 330 blood samples from patients were analyzed by PCR and Southern blot analysis. Initially, DNA from 78 affected individuals were studied by PCR. Since this method is unable to detect high molecular weight alleles, however, we undertook a second approach using the Southern blotting technique to analyze the CGG repeat number and methylation status. Southern blot analysis showed an altered pattern in 14 out of 240 (6%) unrelated patients, with half of them presenting a mosaic pattern. Eight out of 17 families (47%) showed a (suggest deleting highlight). The characteristic FXS pattern was identified in 8/17 families (47%), and in 4 of these families 25% of the individuals presented with a mosaic model. The expansion from pre-mutation to full mutation was shown to occur both at the pre and post zygotic levels. The detection of FXS mutations has allowed us to offer more informed genetic counseling, prenatal diagnosis and reliable patient follow-up.

  9. The radioprotective activities of turpentine-induced inflammation and {alpha}{sub 2}-macroglobulin. The effect of dexamethasone on the radioprotective efficacy of the inflammation

    Energy Technology Data Exchange (ETDEWEB)

    Sevaljevic, L.; Koricanac, G.; Vulovic, M.; Kanazir, D.; Ribarac-Stepic, N. [Vinca Inst. of Nuclear Sciences, Belgrade (Yugoslavia); Dobric, S. [Military Medical Academy, Belgrade (Yugoslavia); Bogojevic, D.; Petrovic, M. [Inst. of Biological Research, Belgrade (Yugoslavia)

    2003-03-01

    This work was aimed at the radioprotective efficacy of turpentine oil (TO), {alpha}{sub 2}-macroglobulin ({alpha}{sub 2}-M), amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD{sub 50/30}). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of {alpha}{sub 2}-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving {alpha}{sub 2}-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1 mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and {alpha}{sub 2}-M enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1 mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities. (author)

  10. Effects of Tinospora cordifolia on macrophage function : a possible role in radioprotection

    International Nuclear Information System (INIS)

    A hydroalcoholic extract of Tinospora cordifolia was earlier evaluated in our laboratory for its radioprotective properties and was found to provide 76 percent survival in lethally irradiated strain A mice. The present study was undertaken to evaluate the effect of Tinospora cordifolia on various macrophage functions

  11. Analyses of radioprotective action and cytotoxicity of various sulfhydryl compounds in cultured mouse L cells

    International Nuclear Information System (INIS)

    The radioprotective action and cytotoxicity of various sulfhydryl compounds; 2-mercaptopropionylglycine (MPG), 2-mercaptopropionylglycine-amide (MPG-amide), 2-mercaptopropionylphenylalanine (MPPA), 2-mercaptopropionylphenylglycine (MPPG), 3-mercaptopropionylglycine (3-MPG), AET, cysteine and cysteamine were compared in irradiated and unirradiated mouse L cells using colony forming ability as a criterion. It was indicated that the sulfhydryl compounds divided into three classes, according to their radioprotective action and toxicity. Most effective radioprotection was obtained by cysteamine and cysteine, followed by AET and MPG-amide in that order. Toxicity of these sulfhydryl compounds were generally observed in concentrations in the range of 0.1 - 2 mM, while they are much less toxic and effectively radioprotective in higher concentration, especially in cysteamine and cysteine. On the other hand, MPG, MPPA, MPPG, and 3-MPG were all non-toxic and generally ineffective in protecting irradiated cells, except that MPG in concentrations around 0.02 mM and 15 mM and MPPA and 3-MPG around 15 mM have a slight but significant protective action. (auth.)

  12. Influence of slow calcium channel inhibitors on radioprotective effect of phenilephrine

    International Nuclear Information System (INIS)

    Verapamil and cinnarizine decrease radioprotective effect of phenylephrine, but nifedipin (more specific inhibitor of slow calcium channel) dosesn't change it. Consequently, protective effect of phenylephine isn't realized by influx of Ca2+ ions through slow calcium channel

  13. Radio-protection problems presented by iodine isotopes in nuclear fuel chemical treatment plants (1962)

    International Nuclear Information System (INIS)

    The origin of radio-iodine and the conditions in which it is liberated are given. The authors review the question of the risks associated with the presence of this radioelement In the atmosphere. Finally a method is proposed for the trapping and rapid measuring of the iodine in the vapour form, applicable to radioprotection. (authors)

  14. Radioprotective Effect of Lidocaine on Function and Ultrastructure of Salivary Glands Receiving Fractionated Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hakim, Samer George, E-mail: samer.hakim@mkg-chir.mu-luebeck.de [Department of Oral and Maxillofacial Surgery, University of Luebeck, Luebeck (Germany); Benedek, Geza Attila [Department of Oral and Maxillofacial Surgery, University of Luebeck, Luebeck (Germany); Su Yuxiong [Department of Oral and Maxillofacial Surgery, University of Luebeck, Luebeck (Germany); Department of Oral and Maxillofacial Surgery, Sun Yat-Sen University, Guanghua School of Stomatology, Guanghua (China); Jacobsen, Hans Christian [Department of Oral and Maxillofacial Surgery, University of Luebeck, Luebeck (Germany); Klinger, Matthias [Institute of Anatomy, University of Luebeck, Luebeck (Germany); Dendorfer, Andreas [Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Luebeck (Germany); Hemmelmann, Claudia [Institute of Medical Biometry and Statistics, University of Luebeck, Luebeck (Germany); Meller, Birgit [Department of Radiology and Nuclear Medicine, University of Luebeck, Luebeck (Germany); Nadrowitz, Roger; Rades, Dirk [Department of Radiation Oncology, University of Luebeck, Luebeck (Germany); Sieg, Peter [Department of Oral and Maxillofacial Surgery, University of Luebeck, Luebeck (Germany)

    2012-03-15

    Purpose: Radiation-induced xerostomia still represents a common side effect after radiotherapy for head-and-neck malignancies. The aim of the present study was to examine the radioprotective effect of lidocaine hydrochloride during fractionated radiation in an experimental animal model. Methods and Materials: To evaluate the influence of different radiation doses on salivary gland function and the radioprotective effect of lidocaine, rabbits were irradiated with 15, 25, 30, and 35 Gy (equivalent doses in 2-Gy fractions equivalent to 24, 40, 48, and 56 Gy, respectively). Lidocaine hydrochloride (10 and 12 mg/kg) was administered before every radiation fraction in the treatment groups. Salivary gland function was assessed by flow sialometry and sialoscintigraphy, and the morphologic changes were evaluated using transmission electron microscopy. Results: Functional impairment was first observed after 35 Gy and pretreatment with lidocaine improved radiation tolerance of both parotid and submandibular glands. The use of 12 mg/kg lidocaine was superior and displayed significant radioprotection with regard to flow sialometry and sialoscintigraphy. The ultrastructure was largely preserved after pretreatment with both lidocaine doses. Conclusions: Lidocaine represents an effective radioprotective agent and a promising approach for clinical application to avoid radiation-induced functional impairment of salivary glands.

  15. Enhancement of the radioprotective effect of hypoxia on animals adapted to hyperoxic conditions

    International Nuclear Information System (INIS)

    In experiments on mice a hypothesis on radioprotective effect of exogenic hypoxia on animal cells adapted to hyperoxic conditions is tested. The survival curves plotted on the basis of 4 experiments on animal irradiation at a dose of 6-16.5 Gy confirmed the validity of adaptation hypothesis

  16. Molecular targets for radioprotection by low dose radiation exposure

    International Nuclear Information System (INIS)

    using splenocytes. High dose radiation up-regulated the expression of HSP25 and especially HSP70; while expression of other HSPs such as HSC70, HSP90, and αB-crystalline did not change. When splenocytes from HSP70 transgenic mice were pre-irradiated with a low dose of radiation, a reduction in cell death by high dose radiation was observed. These results, suggest that HSP70 is a key molecule in radioprotective effect by low dose radiation

  17. Argentine experience in the field of illegal immigration.

    Science.gov (United States)

    Villar, J M

    1984-01-01

    This article provides a brief history of Argentine policy toward migratory flows from neighboring countries and Europe, and concludes with statistics on the number of foreigners in Argentina in the 1970-80 period. Measures passed during the 1940s and 1950s were aimed at providing amnesty for foreigners who were residing in Argentina without immigrant status. However, the lack of an adequate administrative structure to regulate foreigners at the borders was a drawback for migration authorities and limited the possiblility of applying admission criteria effectively. By 1970, there were 583,000 foreigners from neighboring countries living in Argentina, which represented a 25% increase from 1960. 42% of these migrants were in the metropolitan region of the country, indicative of a shift away from employment in agriculture. Decree No. 87, passed in 1974, represented an extension of a migration policy aimed at granting ample facilities for permanent residence to aliens from contiguous countries and was designed to prevent abuse of clandestine workers by employers. As a result of this measure, 150,000 foreigners were able to settle legally in the country. A 1981 law, yet to be implemented, establishes a new legal framework aimed at fostering immigration and regulating the admission of foreigners. To attain the objective of settling workers in areas of the country considered of prime importance to economic development, the law provides for infrastructural investments and promotional measures in areas such as tax exemption and the granting of credit. The 1980 National Population Census indicated there were 677,000 foreigners from neighboring countries in Argentina. In that year, foreigners comprised 2.4% of the country's population and 3.1% of the inhabitants of the metropolitan region. These figures are indicative of a decline in the growth of immigration, most likely due to the decline in the purchasing power of workers' salaries in the late 1970s.

  18. DNA Barcoding Identifies Argentine Fishes from Marine and Brackish Waters

    Science.gov (United States)

    Mabragaña, Ezequiel; Díaz de Astarloa, Juan Martín; Hanner, Robert; Zhang, Junbin; González Castro, Mariano

    2011-01-01

    Background DNA barcoding has been advanced as a promising tool to aid species identification and discovery through the use of short, standardized gene targets. Despite extensive taxonomic studies, for a variety of reasons the identification of fishes can be problematic, even for experts. DNA barcoding is proving to be a useful tool in this context. However, its broad application is impeded by the need to construct a comprehensive reference sequence library for all fish species. Here, we make a regional contribution to this grand challenge by calibrating the species discrimination efficiency of barcoding among 125 Argentine fish species, representing nearly one third of the known fauna, and examine the utility of these data to address several key taxonomic uncertainties pertaining to species in this region. Methodology/Principal Findings Specimens were collected and morphologically identified during crusies conducted between 2005 and 2008. The standard BARCODE fragment of COI was amplified and bi-directionally sequenced from 577 specimens (mean of 5 specimens/species), and all specimens and sequence data were archived and interrogated using analytical tools available on the Barcode of Life Data System (BOLD; www.barcodinglife.org). Nearly all species exhibited discrete clusters of closely related haplogroups which permitted the discrimination of 95% of the species (i.e. 119/125) examined while cases of shared haplotypes were detected among just three species-pairs. Notably, barcoding aided the identification of a new species of skate, Dipturus argentinensis, permitted the recognition of Genypterus brasiliensis as a valid species and questions the generic assignment of Paralichthys isosceles. Conclusions/Significance This study constitutes a significant contribution to the global barcode reference sequence library for fishes and demonstrates the utility of barcoding for regional species identification. As an independent assessment of alpha taxonomy, barcodes provide

  19. DNA barcoding identifies Argentine fishes from marine and brackish waters.

    Directory of Open Access Journals (Sweden)

    Ezequiel Mabragaña

    Full Text Available BACKGROUND: DNA barcoding has been advanced as a promising tool to aid species identification and discovery through the use of short, standardized gene targets. Despite extensive taxonomic studies, for a variety of reasons the identification of fishes can be problematic, even for experts. DNA barcoding is proving to be a useful tool in this context. However, its broad application is impeded by the need to construct a comprehensive reference sequence library for all fish species. Here, we make a regional contribution to this grand challenge by calibrating the species discrimination efficiency of barcoding among 125 Argentine fish species, representing nearly one third of the known fauna, and examine the utility of these data to address several key taxonomic uncertainties pertaining to species in this region. METHODOLOGY/PRINCIPAL FINDINGS: Specimens were collected and morphologically identified during crusies conducted between 2005 and 2008. The standard BARCODE fragment of COI was amplified and bi-directionally sequenced from 577 specimens (mean of 5 specimens/species, and all specimens and sequence data were archived and interrogated using analytical tools available on the Barcode of Life Data System (BOLD; www.barcodinglife.org. Nearly all species exhibited discrete clusters of closely related haplogroups which permitted the discrimination of 95% of the species (i.e. 119/125 examined while cases of shared haplotypes were detected among just three species-pairs. Notably, barcoding aided the identification of a new species of skate, Dipturus argentinensis, permitted the recognition of Genypterus brasiliensis as a valid species and questions the generic assignment of Paralichthys isosceles. CONCLUSIONS/SIGNIFICANCE: This study constitutes a significant contribution to the global barcode reference sequence library for fishes and demonstrates the utility of barcoding for regional species identification. As an independent assessment of alpha

  20. Genetic variability and population structure in loci related to milk production traits in native Argentine Creole and commercial Argentine Holstein cattle

    Directory of Open Access Journals (Sweden)

    Golijow C.D.

    1999-01-01

    Full Text Available Many cattle breeds have been subjected to high selection pressure for production traits. Consequently, population genetic structure and allelic distribution could differ in breeds under high selection pressure compared to unselected breeds. Analysis of k-casein, aS1-casein and prolactin gene frequencies was made for Argentine Creole (AC and Argentine Holstein (AH cattle herds. The calculated FST values measured the degree of genetic differentiation of subpopulations, depending on the variances of gene frequencies.The AC breed had considerably more variation among herds at the aS1-casein and k-casein loci. Conservation strategies should consider the entire AC population in order to maintain the genetic variability found in this native breed.

  1. Cryptozoology Society

    Science.gov (United States)

    Richman, Barbara T.

    Reports of Loch Ness monsters, Bigfoot, and the Yeti spring u p from time to time, sparking scientific controversy about the veracity of these observations. Now an organization has been established to help cull, analyze, and disseminate information on the alleged creatures. The International Society of Cryptozoology, formed at a January meeting at the U.S. National Museum of Natural History of the Smithsonian Institution, will serve as the focal point for the investigation, analysis, publication, and discussion of animals of unexpected form or size or of unexpected occurrences in time or space.

  2. Protection of the environment. How to position radioprotection in an ecological risk assessment perspective

    International Nuclear Information System (INIS)

    The development of a system capable of ensuring adequate protection of the environment from the harmful effects of ionising radiation is at present particularly debated. This need comes both from a restrictive consideration of the environment in the so far existing system for human radioprotection, and the planetary-wide growing concerns about man's technogenic influence on his environment which have yielded 'sustainability' and 'precaution' as guiding principles for environmental protection. Whilst evolving from the field of human radioprotection, the radioprotection of the environment needs to be discussed in a wider perspective, with particular emphasis on the most advanced concepts which emerge from the efforts to deriving improved approaches to Ecological Risk Assessment. For the sake of protection, the environment is traditionally addressed through its biota since these are the sensitive components of ecosystems. Similarities between man and biotas reflect the ubiquitous mechanistic effects of radiation on life which disrupt molecules. However, important differences also arise in a number of perspectives, from the large spectrum of different species of biotas to their hierarchical self-organisation as interacting populations within ecosystems. Altogether, these aspects are prone to promote complex arrays of different responses to stress which lie beyond the scope of human radioprotection due to its focus on individuals of a single species. By means of selected illustrations, this paper reviews and discusses the current challenges faced in proper identification of measurable effect endpoints (stochastic/deterministic, individual/population- or ecosystem-relevant), dose limits in chronic exposure (or levels of concern), and their consideration according to radiation type (RBE) and interactions with other contaminants (synergies/antagonisms) which represent critical gaps in knowledge. The system of human radioprotection has conceptually been targeted at limiting

  3. Radioprotective cerium oxide nanoparticles: Molecular imaging investigations of conps' pharmacokinetics, efficacy, and mechanisms of action

    Science.gov (United States)

    McDonagh, Philip Reed Wills, III

    Cerium oxide nanoparticles (CONPs) are being investigated for several anti-oxidant applications in medicine. One of their most promising applications is as a radioprotective drug, an area of research in need due to the severe side effects from radiation therapy. In this work, the potential of CONPs as a radioprotective drug is examined using four criteria: favorable biodistribution/pharmacokinetics, low toxicity, ability to protect normal tissue from radiation damage, and lack of protection of tumor. The mechanisms of action of CONPs are also studied. Biodistribution was determined in radiolabeled CONPs with surface coatings including citrate, dextran T10-amine (DT10-NH2), dextran T10-polyethylene glycol (DT10-PEG), dextran T10-sulfobetaine (DT10-SB) and poly(acrylic acid) (PAA), and compared to uncoated. 89Zr was incorporated into CONPs for positron emission tomography (PET) imaging and ex vivo tissue analysis in tumor bearing mice. Compared to uncoated [ 89Zr]CONPs, coated [89Zr]CONPs showed improved biodistribution, including significantly enhanced renal clearance of PAA- [89Zr]CONPs. The toxicity of CONPs was evaluated in vitro and in vivo, with low toxicity at therapeutic doses. After clinically mimetic radiation therapy, pre-treatment of mice with coated and uncoated CONPs showed greater than 50% reduction of cell death in normal colon tissue, comparable to the clinically available radioprotective drug amifostine. Tumor control after irradiation of spontaneous colon tumors was unchanged with PAA-CONP pre-treatment, while citrate, DT10-PEG, and uncoated CONP pre-treatment had slightly less tumor control. Xenograft tumors were irradiated after pH normalizing treatment with sodium bicarbonate and PAA-CONP pre-treatment. Treatment of these tumors showed slightly less tumor control than irradiation alone or PAA-CONP plus irradiation, demonstrating that the acidic pH of the tumor microenvironment may be the basis of preventing CONPs' radioprotective properties in

  4. On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes

    Energy Technology Data Exchange (ETDEWEB)

    Rinaldi, R.; Bernard, Y. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study certain derivatives of imidazole and other compounds of similar structure. The results obtained showed: 1 - that the derivatives resulting from the presence in the imidazole ring of the mercapto, methyl, carbonyl, or benzyl groups are inactive: these substitutions appear to destroy the significant radioprotective activity of the imidazole, 2 - that benzimidazole, on the contrary, seems to possess highly interesting properties. The percentage of survivals obtained with mice treated with benzimidazole and exposed to lethal irradiation has encouraged the authors to undertake careful study of this substance, with a view to define optimum activity conditions, and to determine the mechanism responsible for its radioprotective action. Further on and so as to of clarify certain points that might give useful data concerning the mechanisms of action of radioprotective chemicals, in respect of each of the products the authors have studied: a - the action of these bodies on the internal temperature of mice, b - their radioprotective activity in vitro, in a solution of irradiated hemin. (authors) [French] Les proprietes radioprotectrices de l'imidazole ayant ete mises en evidence dans un precedent travail, les auteurs poursuivent leur experimentation sur certains derives de ce noyau ainsi que des composes de structure voisine. Leurs resultats montrent: 1 - que les composes obtenus par substitution d'un groupement mercapto, methyle, carbonyle ou benzyle, a un hydrogene du noyau imidazole sont inactifs, 2 - que le benzimidazole presente par contre des proprietes interessantes. Pour ce dernier compose le pourcentage de survie pouvant atteindre 90 pour cent les auteurs ont determine les conditions optimales de son activite radioprotectrice; de plus, dans le but d'obtenir des renseignements susceptibles de preciser le mecanisme d'action de la

  5. Behavioural and chemical evidence for multiple colonisation of the Argentine ant, Linepithema humile, in the Western Cape, South Africa

    Directory of Open Access Journals (Sweden)

    Wossler Theresa C

    2011-02-01

    Full Text Available Abstract Background The Argentine ant, Linepithema humile, is a widespread invasive ant species that has successfully established in nearly all continents across the globe. Argentine ants are characterised by a social structure known as unicoloniality, where territorial boundaries between nests are absent and intraspecific aggression is rare. This is particularly pronounced in introduced populations and results in the formation of large and spatially expansive supercolonies. Although it is amongst the most well studied of invasive ants, very little work has been done on this ant in South Africa. In this first study, we investigate the population structure of Argentine ants in South Africa. We use behavioural (aggression tests and chemical (CHC approaches to investigate the population structure of Argentine ants within the Western Cape, identify the number of supercolonies and infer number of introductions. Results Both the aggression assays and chemical data revealed that the Western Cape Argentine ant population can be divided into two behaviourally and chemically distinct supercolonies. Intraspecific aggression was evident between the two supercolonies of Argentine ants with ants able to discriminate among conspecific non-nestmates. This discrimination is linked to the divergence in cuticular hydrocarbon profiles of ants originating from the two supercolonies. Conclusions The presence of these two distinct supercolonies is suggestive of at least two independent introductions of this ant within the Western Cape. Moreover, the pattern of colonisation observed in this study, with the two colonies interspersed, is in agreement with global patterns of Argentine ant invasions. Our findings are of interest because recent studies show that Argentine ants from South Africa are different from those identified in other introduced ranges and therefore provide an opportunity to further understand factors that determine the distributional and spread

  6. Annual Report 2007 - ABACC - Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials

    International Nuclear Information System (INIS)

    This document reports activities during the year 2007 related to: technical activities as application of safeguards; management of the Quadripartite Agreement and the SCCC - Common System for Accounting and Control of Nuclear Materials; training; technical cooperation; outlook for 2008 and; institutional, administrative and financial activities; technical glossary; list of brazilian facilities; list of argentine facilities and a list of institution of nuclear area

  7. Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile).

    Science.gov (United States)

    Smith, Christopher D; Zimin, Aleksey; Holt, Carson; Abouheif, Ehab; Benton, Richard; Cash, Elizabeth; Croset, Vincent; Currie, Cameron R; Elhaik, Eran; Elsik, Christine G; Fave, Marie-Julie; Fernandes, Vilaiwan; Gadau, Jürgen; Gibson, Joshua D; Graur, Dan; Grubbs, Kirk J; Hagen, Darren E; Helmkampf, Martin; Holley, Jo-Anne; Hu, Hao; Viniegra, Ana Sofia Ibarraran; Johnson, Brian R; Johnson, Reed M; Khila, Abderrahman; Kim, Jay W; Laird, Joseph; Mathis, Kaitlyn A; Moeller, Joseph A; Muñoz-Torres, Monica C; Murphy, Marguerite C; Nakamura, Rin; Nigam, Surabhi; Overson, Rick P; Placek, Jennifer E; Rajakumar, Rajendhran; Reese, Justin T; Robertson, Hugh M; Smith, Chris R; Suarez, Andrew V; Suen, Garret; Suhr, Elissa L; Tao, Shu; Torres, Candice W; van Wilgenburg, Ellen; Viljakainen, Lumi; Walden, Kimberly K O; Wild, Alexander L; Yandell, Mark; Yorke, James A; Tsutsui, Neil D

    2011-04-01

    Ants are some of the most abundant and familiar animals on Earth, and they play vital roles in most terrestrial ecosystems. Although all ants are eusocial, and display a variety of complex and fascinating behaviors, few genomic resources exist for them. Here, we report the draft genome sequence of a particularly widespread and well-studied species, the invasive Argentine ant (Linepithema humile), which was accomplished using a combination of 454 (Roche) and Illumina sequencing and community-based funding rather than federal grant support. Manual annotation of >1,000 genes from a variety of different gene families and functional classes reveals unique features of the Argentine ant's biology, as well as similarities to Apis mellifera and Nasonia vitripennis. Distinctive features of the Argentine ant genome include remarkable expansions of gustatory (116 genes) and odorant receptors (367 genes), an abundance of cytochrome P450 genes (>110), lineage-specific expansions of yellow/major royal jelly proteins and desaturases, and complete CpG DNA methylation and RNAi toolkits. The Argentine ant genome contains fewer immune genes than Drosophila and Tribolium, which may reflect the prominent role played by behavioral and chemical suppression of pathogens. Analysis of the ratio of observed to expected CpG nucleotides for genes in the reproductive development and apoptosis pathways suggests higher levels of methylation than in the genome overall. The resources provided by this genome sequence will offer an abundance of tools for researchers seeking to illuminate the fascinating biology of this emerging model organism. PMID:21282631

  8. Abstracts of the 81. national meeting on physics of the Argentine Physics Association (AFA)

    International Nuclear Information System (INIS)

    Abstracts are presented at the 81 Annual meeting of the Argentine Physics Association (AFA). The papers can be grouped under the following main topics: teaching, history and philosophy of physics; classical and quantum physics: particles and fields; statistical physics and thermodynamics; nuclear physics; atomic and molecular physics; optic; fluid dynamics and plasmas; condensed matter; instrumentation; geophysics and astrophysics. refs., ills

  9. English as an Instrumental Language: Language Displacement in the Anglo-Argentine Community.

    Science.gov (United States)

    Cortes-Conde, Florencia

    1994-01-01

    Surveyed 99 Anglo-Argentine students aged 10 through 18 at five Spanish-English bilingual schools in Buenos Aires about their language attitudes and usage. It found that, despite the prestige of the English language, Spanish had become the dominant language for most. Age and place of residency in Buenos Aires also had a significant effect on…

  10. The Information Center of the Argentine National Board of Nuclear Regulation (ENREN)

    International Nuclear Information System (INIS)

    This paper is addressed particularly to the scientific community users and, as a whole, to any individual in society, whichever his profession or working environment, who is interested in getting acquainted of improving his/her knowledge in the areas of radiological protection and nuclear safety, as well as in other related areas of medicine, biology, engineering, mathematics and physics. The purpose of this paper is the diffusion of the broad spectrum of bibliography and the introduction of the technological-computerized media utilized as tools by the Argentine National Board of Nuclear Regulation in providing responses to a huge number of both internal and external requests for information. There is a large number of professionals and/or researchers who visit the facilities of our Information Center or who get in touch - through the post service, e-mail or telephone - consulting on the available material, either in paper (books, periodical publications, etc.) or in the form of microfilms, video, tapes, CD-ROM, etc. This paper is both descriptive and explanatory; a description is provided of the bibliographical material managed by the Information Center and a brief explanation is given on the techniques and methods used in providing the information requested by the users. Fundamentally, the Center's bibliographical material includes: periodical publications, books, reports, microfilms, etc., all of them related to radiological protection and nuclear safety. Data bases are available in CD-ROM, the most important one being the International Nuclear Information System (INIS) developed by the International Atomic Energy Agency (IAEA). The Center has also its own data bases, such as the GPRS (primary documents) and standards (both domestic and international), UNESCO's MicroIsis software is used for the Center's data bases: PERSIS (periodical publications), DOCSIS (books) and ARCAL (magazines from the Latin American territory). This paper will definitely serve as a safe

  11. Powerful motors: Kinship, citizenship and the transformation of the Argentine oil industry

    Science.gov (United States)

    Shever, Elana

    The privatization of the Argentine oil industry has been described as an unprecedented transfer of property, capital and control from the state to the corporate sphere, but this study demonstrates that the privatization process is better understood as a transformation of the historical configurations of oil-fueled development, political communities and human subjectivities. This dissertation probes the development of the state-led oil industry, and the shift to a corporate-led one, through an ethnography of Argentines differently positioned in relation to the global oil industry. The ethnography explores the lives of middle class oil workers and their families in Northwest Patagonia, impoverished residents of the shanty neighborhoods near the refineries in metropolitan Buenos Aires, and affluent employees of the translocal corporations operating in the Argentine oil fields. After the Introduction delineates this study's four principal interventions into anthropological scholarship, each subsequent chapter engages a particular problem that cuts across the Argentine oil fields and the anthropological theoretical fields. Chapter Two scrutinizes the historical construction of the Argentine subterritory as a "natural" space of value. Chapters Three and Four investigate the articulation of capitalist production and filial reproduction. These chapters argue that sentiment is a crucial generative force that has shaped the oil industry, company towns and worker families from the founding of the state-owned oil company in beginning of the twentieth century to its conversion into a corporate-owned one at the century's close. Chapters Five and Six examine the emergence of consumer citizenship and corporate citizenship out of Argentine neoliberalismo and its transformation of the oil industry. They argue that consumer and corporate citizenship are both reformulations of the older traditions of liberalism and Peronism. All the chapters of this dissertation illustrate that the

  12. NF ISO 15382. Nuclear energy - Radioprotection - Procedure of radioprotection dosimetry monitoring in nuclear facilities for the external exposure to weakly penetrant radiations, in particular the beta radiation

    International Nuclear Information System (INIS)

    This international standard specifies a dosimetry monitoring procedure for the radiation protection inside nuclear facilities and concerns the external exposure to weakly penetrant radiations, i.e.: beta, beta +, conversion electrons, and photons with an energy < 15 keV. It describes the procedure of radioprotection organization and control, and the measurements and analyses to be implemented. It applies to the operations regularly performed in nuclear reactors, like maintenance, handling of wastes and dismantling activities. These recommendations can be transferred to other nuclear domains, including the fuel fabrication and reprocessing, the accelerators, and the nuclear medicine, biology and research facilities. (J.S.)

  13. Melatonin; an Established Radioprotective Agent Against JapanAND#8217;s Nuclear Disaster

    Directory of Open Access Journals (Sweden)

    Ahmet Korkmaz

    2011-04-01

    Full Text Available In spite of its widespread use and the well known potential hazards associated with exposure to ionizing radiation, countries are poorly ill-equipped to protect their citizens in case of a fallout as seen in northeastern region of Japan. In case of nuclear fallout, there is no practical way to save people from the hazardous effects of ionizing radiation. Health authorities may provide potassium iodide for people to prevent thyroid cancer. Another preventive attempt would be using amifostine, a well known agent with radioprotective features. Melatonin (N-acetyl-5-methoxytryptamine is a pineal product which is also known to have robust radioprotective features. Both human and experimental animal studies have clearly shown that it is a unique antioxidant and a DNA and chromosome protector against a variety of harmful agents including ionizing radiation. [TAF Prev Med Bull 2011; 10(2.000: 127-129

  14. Radioprotective effects of Cordyceps sinensis extracts on {gamma}-irradiated mice

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Beong Gyu [Wongwang Health Science College, Iri (Korea, Republic of); Kim, On Joong; Kim, Jae Young [Dongguk University, Seoul (Korea, Republic of)

    1999-06-01

    Effect of single intraperitoneal administration of Cordyceps sinensis (Cs) extract at 24 hour before whole-body {gamma} - irradiation on the survival ratio, body weight, organ weight changes and serum metabolites in the irradiated mice were investigated. The single pre-administration of Cs extract increased the 40-day survival ration of irradiated mice from 66.7 percent to 83.4 percent. The administration of Cs extract completely prevented weight reductions of spleen and thymus produced by {gamma} - irradiation (P < 0.05, P < 0.01). Similar but somewhat less radioprotective effect was also found in the testis of the Cs treated mice. The administration of Cs inhibited the serum hyperglycemia produced by irradiation on the day 7th(P < 0.01). However, it did not influence the serum cholesterol and protein levels on the days examined. The present study is the first report regarding Cs which was tested and found to be radioprotective. (Author)

  15. Radioprotection of the intestinal crypts of mice by recombinant human interleukin-1 alpha

    International Nuclear Information System (INIS)

    Recombinant human interleukin-1 alpha (rHIL-1 alpha or IL-1) protected the intestinal crypt cells of mice against X-ray-induced damage. The survival of crypt cells measured in terms of their ability to form colonies of regenerating duodenal epithelium in situ was increased when IL-1 was given either before or after irradiation. The maximum degree of radioprotection was seen when the drug was given between 13 and 25 h before irradiation. The IL-1 dose producing maximum protection was about 6.3 micrograms/kg. This is the first report indicating that the cytokine IL-1 has a radioprotective effect in the intestine. The finding suggests that IL-1 may be of potential value in preventing radiation injury to the gut in the clinic

  16. ASN report on nuclear safety and radioprotection status in France in 2010

    International Nuclear Information System (INIS)

    After a general overview of the activity of the ASN (the French nuclear safety authority), of its missions and organisation, this activity report indicates the main events of 2010 concerning the actions performed by the ASN and the activities controlled by the ASN. These both aspects are then detailed. The actions performed by the ASN are dealing with nuclear activities (ionizing radiations and risks for health and for the environment), principles and actors of nuclear safety control, radioprotection and environment protection, regulation, control of nuclear activities and exposures to ionizing radiations, emergency situations, public information, international relationship, regional overview of nuclear safety and radioprotection. The activities controlled by the ASN are the medical uses of ionizing radiations, their non medical uses, the transport of radioactive materials, electronuclear plants, installations related to nuclear fuel cycle, nuclear research installations and other nuclear installations, the safety of nuclear installation dismantling, radioactive wastes and polluted sites

  17. Establishment of a novel screening method to promptly develop a radioprotective agent

    International Nuclear Information System (INIS)

    Described is the method in the title, where the radioprotective effect can be screened in vitro by inhibition of X-ray induced-shrinkage of rat thymocyte. The method is of advantages of the smaller amount of test agent, shorter test time, simpler and less expensive procedure, and objectiveness of the effect observation. Thymocytes isolated from the rat thymus are mixed with the test agent, irradiated with 2 Gy of X-ray generated from the PANTAC (Shimadzu), cultured for 4 hr and then measured for their cellular areas by the flow-cytometry with FACSCalibur (BD Biosciences). Rat thymocytes have been found more sensitive to radiation than mouse cells. Dead thymocytes can be clearly distinguishable from livings by their shrink without formation of apoptotic body. The screening system includes the control, vehicle (dimethylsufoxide) control, and + test agent. For actual trials, such antioxidants as catechin, curcumin, resveratrol, vitamin E, vitamin C, caffeinic acid and quercetin are tested: with vs without X-ray treatment, percentages of dead cells after 4 hr-culture give the radioprotection vs cell toxicity of the agents, respectively. In contrast to controls (dead cells 40-45% with vs 20-22% without X-ray), test agents give the results of 17-95% vs 16-92%, respectively. It is found that V.C is toxic above 100 mc-M and has no radioprotective effect while caffeinic acid, non-toxic at 100 mc-M (dead cells 27.34%) or 1 mM (16.27%) without X-ray and radioprotective (29.56% or 17.59%, respectively) with irradiation. The established system including the method, screening kit and analytical program, is under application for patent. (T.T.)

  18. Study and realisation of a microdosimetric detector intended to radioprotection measurement

    International Nuclear Information System (INIS)

    This work concerns the realisation of a tissue equivalent proportional counter. The detector, which is sensitive to neutron and gamma radiations is intended to measure dose equivalent for radioprotection use. The microdosimetric analysis of the pulses allows us to calculate the absorbed dose and the quality factor, it is possible to discriminate the two kinds of particules. This work is a first step before making an electronical individual dosemeter

  19. Nuclides.net: A computational environment for nuclear data and applications in radioprotection and radioecology

    International Nuclear Information System (INIS)

    An interactive multimedia tool, Nuclides.net, has been developed at the Institute for Transuranium Elements. The Nuclides.net 'integrated environment' is a suite of computer programs ranging from a powerful user-friendly interface, which allows the user to navigate the nuclides chart and explore the properties of nuclides, to various computational modules for decay calculations, dosimetry and shielding calculations, etc. The product is particularly suitable for environmental radioprotection and radioecology. (authors)

  20. Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future.

    Science.gov (United States)

    Baliga, Manjeshwar Shrinath; Haniadka, Raghavendra; Pereira, Manisha Maria; Thilakchand, Karadka Ramdas; Rao, Suresh; Arora, Rajesh

    2012-07-01

    Radiation is an important modality in treating people with cancer especially when surgical intervention is impracticable or might debilitate the patient. However, effective use of ionizing radiation is compromised by the side effects that result from radiation-induced damage to normal tissue. The use of radioprotective compounds, which can selectively protect normal tissues against radiation injury is of immense use because in addition to association with protecting the normal tissue, it will also permits use of higher doses of radiation to obtain better cancer control and possible cure. However, till date no ideal radioprotectors are available as most synthetic compounds are toxic at their optimal concentrations. Plants commonly used as dietary and or therapeutic agents have recently been the focus of attention since in most cases they are non-toxic and are easily accepted for human use. Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), has widely been used as both culinary and medicinal agent. Preclinical studies carried out in the last decade has shown that ginger and its phytochemicals dehydrozingerone, zingerone possess radioprotective effects in laboratory animals and in cultured cells in vitro. The hydroalcoholic extract of ginger rhizome when administered either through intraperitoneal or oral route was effective in protecting against gamma radiation-induced sickness and mortality. The phytochemicals dehydrogingerone and zingerone present in ginger are also shown to protect mice against radiation-induced sickness and mortality. Mechanistic studies have indicated that the free radical scavenging, antioxidant affects, anti-inflammatory and anti-clastogenic effects may contribute towards the observed protection. Additionally, studies with tumor bearing mice have also shown that zingerone selectively protects the normal tissues against the tumoricidal effects of radiation. This review for the first time summarizes the results related to the

  1. Development of enhanced radioprotectors - Biochemical and molecular genetical approaches on the radioprotective mechanism of natural products

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Hee; Lee, Eun Ju; Hong, Jung A [Kyunghee University, Seoul (Korea)

    2000-04-01

    To identify radio-protective agent candidate among medicinal plants and to elucidate the mechanism of action of the candidate material by using modern biochemical and molecular biological methods, we screened radio-protective activity among 48 medicinal plants. Seven samples showed above 20% protective activities against oxidative cell damage: Euryale ferox, Glycyrrhiza uralensis, Salvia miltiorrhiza, Eucomia ulmoides, Paeonia suffruticosa, Spirodela polyrrhiza, and Nelumbo nucifera. We also screened for oxidative stress sensitizing activity among other 51 medicinal plants. Among those samples, 11 samples showed good sensitizing effect; Melia azedarach, Agastache rugosa, Catalpa ovata, Prunus persica, Sinomenium acutum, Pulsatilla koreana, Oldenlandia diffusa, Anthriscus sylvestris, Schizandra chinensis, Gleditsia sinensis, and Cridium officinale. We also reported the radio-protective effect of DTT. The treatment of DTT increased cell survival after gamma-irradiation, decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after UV-C irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. 165 refs., 9 figs., 8 tabs. (Author)

  2. Study of radioprotective effect of the resveratrol;Estudo do efeito radioprotetor do resveratrol

    Energy Technology Data Exchange (ETDEWEB)

    Moreno, Carolina dos Santos

    2009-07-01

    Resveratrol (3,4,5 trihydroxystilbene), a phenolic phytoalexin occurring naturally in a wide variety of plants, such as grapevines, in response to injury as fungal infections and exposure to ultraviolet light. In the wines this compound is present at high levels and is considered one of the highest antioxidant constituents. This high capacity to scavenge the free radicals generated by several biologic processes by resveratrol can provide a prevention of human cardiovascular diseases and several types of cancer. The main objective of this study was to determine the in vitro radioprotective effect of resveratrol in cell culture with the aid of the tests of cytotoxicity of resveratrol (IC50%) and lethal dose 50% of gamma radiation (LD50). Studies of the level of resveratrol toxicity, found by cytotoxicity test performed by neutral red uptake assay, and lethal dose 50% (LD50) of gamma radiation from source of Cobalt-60 (Co-60) was performed in cell culture NCTC Clone 929 from ATCC. The IC50% of resveratrol was about 50 M/L. The DL50 of gamma radiation showed a value of about 354 Gy. On the basis of these biological results, it was performed studies of radioprotective effect of resveratrol on the same experimental conditions, verifying that the resveratrol in concentrations between 12.5 M/L and 25 M/L showed a more pronounced radioprotective effect. (author)

  3. Radioprotection against radiation induced bone marrow syndrome by a semi-synthetic derivative of chlorophyll

    International Nuclear Information System (INIS)

    A plethora of biological properties have been attributed to chlorophyllin (CHL), the water soluble derivative of the green plant pigment chlorophyll. Several studies are available describing its ability to modify genotoxic effects. It has been shown that administration CHL to human lymphopenic individuals led to the recovery and restoration of the immune system and also inhibited aflatoxin B1-DNA binding in individuals residing in high risk exposure to this liver carcinogen. The present study is aimed at establishing radioprotective efficacy of CHL against ionizing radiation induced hematopoietic syndrome. CHL offered complete protection against whole body irradiation (WBI, 7 Gy) induced mortality in mice. This observation was supported by increase in the number of macroscopic endogenous colonies enumerated on the surface of the spleens taken from CHL+WBI group as compared to WBI group. Radioprotection by CHL was found to be mediated by increasing the frequency of hematopoietic stem cells (HSCs) as evaluated by side population assay. Administration of CHL induced G1 arrest in bone marrow cells, increased number of granulocytes and neutrophils in the peripheral blood. At the molecular level, activation of ERK was observed in bone marrow cells obtained from CHL administered mice. In conclusion, CHL mediated radioprotection was attributed to increased stem cell numbers, G1 arrest in bone marrow cells, increased neutrophil numbers and ERK activation. (author)

  4. Radioprotective effect of an acute non-specific inflammation in mice

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Laval, J.D.; Fatome, M.; Fauve, R.M.

    1987-03-01

    Protection against 8.7 Gy whole-body ..gamma..irradiation (lethal in 100% of mice by 30 days) was observed in 90% of mice bearing a one-day-old granuloma induced by polyacrylamide beads. When the inflammatory reaction was induced sooner or later a lower or null protection was obtained. A dose-effect relationship between the volume of injected beads and resulting radioprotection was established. The radioprotective effect depends only on the acute non-specific inflammation since hydrocortisone acetate injected into mice before the beads abolished this protection. This inflammatory pattern led to a dose reduction factor of 1.36 +- 0.08 (P < 0.05) for Ld 50/30. A 90% survival was observed in mice bearing a one-day-old granuloma when they injected 1 h before 10 Gy with the granuloma acellular eluate (P < 0.02 compared to a 50 per cent survival observed with polyacrylamide beads alone). Substances with a molecular weight higher than 300,000 are involved in the synergistic radioprotective effect of the granuloma-eluate association.

  5. Radioprotection optimization in the electro-nuclear, industrial and medical fields

    International Nuclear Information System (INIS)

    This document proposes abstracts of interventions which have been proposed during a two-day meeting in Saint-Malo in September 2010. Thus, it evokes recent legal and regulatory evolutions (new recommendations by the International Commission for Radiological Protection or ICRP, the new Basic Safety Standards of BSS of the European Commission), the optimization in the electro-nuclear field (overview of the situation for the main nuclear operators, practical examples of radioprotection optimization through the ALARA approach), in the industrial field (ALARA approach for the design of the International Fusion Materials Irradiation Facility of IFMIF, alternative techniques of use of industrial gamma-graphy, radon management in private dwelling in Switzerland, optimization implementation in NORMS companies, management of solids and sites polluted by radioactive substances), in the medical field (teaching in radioprotection, use of ALARA in design in a proto-therapy centre, development of alternative techniques for the use of ionizing radiations in the medical field, use of diagnosis reference levels for optimization in radio-diagnosis, ALARA in veterinary radio-diagnosis, optimization of doses in nuclear medicine, optimization in interventional radiology). A last set of interventions dealt with the activity international networks for the development of radioprotection

  6. Studies of the radioprotective properties of nicotinyl compounds, aspartic acid, glutamic acid and methionine

    International Nuclear Information System (INIS)

    Radioprotective properties of sodium salts of nicotinyl aspartic acid, nicotinyl methionyl aspartic acid and nicotinyl glutamic acid were tested in mice (NMRI). Experimental animals were irradiated by rayage (9,5 Gy). Parameters were: survival rate, peritoneal fluid cell count, weight and DNA concentration of spleen, hepatic DNA polymerase activity and rate of protein synthesis, lactate dehydrogenase activity in serum, maltase, sucrase and leucine aminopeptidase activitiy in duodenum and jejunum. Following results were obtained: 1. There was no significant difference in survival rate of treated and untreated animals. In treated animals only a short prolongation of survival time was observed. 2. After irradiation a quick reduction of splenic weight and DNA concentration was measured. 3. A reduction of DNA polymerase activity in liver was observed in treated and untreated mice. The rate of hepatic protein synthesis was similar in all animals. A final decrease was observed. 4. Variable activities of maltase, sucrase and leucine aminopeptidase activity in duodenum and jejunum indicated no radioprotective effect of tested substances. In conclusion of these results the tested substances show no significant radioprotective properties. (orig.)

  7. Evaluation of the free radical scavenging activity and radioprotective efficacy of Grewia asiatica fruit

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Krishna V; Sisodia, Rashmi [Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan-302055 (India)], E-mail: rashsisodia@yahoo.co.in

    2009-09-01

    The radioprotective effect of Grewia asiatica fruit (GAE) which contains anthocyanin-type cyanidin 3-glucoside, vitamins C and A, minerals, carotenes and dietary fibre was studied. For the study Swiss albino mice were divided into five groups: (1) control (vehicle treated); (2) GAE treated (700 mg kg{sup -1} day{sup -1} for 15 days); (3) irradiated (5 Gy); (4) GAE+irradiated and (5) irradiated+GAE treated. The irradiation of animals resulted in a significant elevation of lipid peroxidation in terms of thiobarbituric acid reactive substances (TBARS) content and depletion in glutathione (GSH) and protein levels at all intervals studied, namely 1-30 days, in comparison to the control group. Treatment of mice with GAE before and after irradiation caused a significant depletion in TBARS content followed by a significant elevation in GSH and protein concentration in the intestine and testis of mice at all post-irradiation autopsy intervals in comparison to irradiated mice. Significant protection of DNA and RNA in testis was also noticed. GAE was found to have strong radical scavenging activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH{sup *}) and O{sub 2}{sup -} assays and also showed in vitro radioprotective activity in protein carbonyl assay in a dose-dependent manner. The above results prove the radioprotective efficacy of GAE.

  8. Radioprotection of patients and workers in interventional and operating block radiology; La radioprotection des patients et des travailleurs en radiologie interventionnelle et au bloc operatoire

    Energy Technology Data Exchange (ETDEWEB)

    Menechal, P. [Autorite de Surete Nucleaire, Div. de Bordeaux, 33 (France); Valero, M.; Megnigbeto, C.; Marchal, C.; Godet, J.L. [Autorite de surete nucleaire, Dir. des rayonnements ionisants et de la sante, 75 - Paris (France)

    2011-03-15

    Over the last ten years or so, extensive development in radiological and implantable equipment has generated significant growth in radio-guided procedures. The real benefit of these practices to patients explains their development. These procedures can be undertaken using not only dedicated, specific fixed installations and computed tomography scanners, but also mobile installations in facilities not designed for radiography, such as operating blocks. The complexity of these procedures and the times spent implementing the required radiation can lead to major detrimental effects on personnel and patients, if they are not fully controlled. Many specialist medical disciplines now perform invasive procedures guided by images. Optimisation of patient doses mainly depends on the training level of medical teams, the intrinsic performance characteristics of the equipment used, adjustment of the technical parameters and the presence or absence of qualified personnel. Optimisation of professional personnel exposure is complex and depends on the performance conditions of procedures, which can expose workers extensively and non-uniformly. Designation of personnel competent in radioprotection, assessment of risks and definition of controlled areas, analysis of workstations and dosimetric monitoring of operators (especially of body extremities) are difficult to implement. Use of collective and personal protective equipment must be improved. The general manager of the French nuclear safety authority (ASN) has referred the matter to the permanent group of radioprotection experts (GPMED) to ensure that recommendations are drawn up in the short term. (authors)

  9. Making Sense of an Unstable Legislature: Committee Assignments in the Argentine Chamber of Deputies, 1946–2001

    OpenAIRE

    Silvina Lilian Danesi; Carleton University; Ludovic Rheault; University of Montreal

    2012-01-01

    Latin American legislatures have gone largely unstudied, with the functioning of the Argentine Chamber of Deputies prior to the 1980s being an entirely unexplored subject. This paper fills that gap by examining the organization of the Chamber, with particular focus on its standing committee system from 1946 to 2001. We assess the portability of two U.S.-based theoretical approaches to legislative organization by applying them to committee assignments. An original data set of Argentine deputie...

  10. Indirect effects of Argentine ant and honeydew-producing insect mutualisms on California red scale in a citrus agroecosystem

    OpenAIRE

    Kizner, Michelle Cara

    2010-01-01

    In San Diego County, a major economic impact of the Argentine ant occurs in citrus agroecosystems, where ants interfere with biological control of key insect pests, especially California red scale. Ant control is considered a critical component of integrated pest management (IPM) of several citrus pests, but IPM recommendations fail to consider quantitative relationships between levels of Argentine ant abundance and those of the economic pests. This serious gap in understanding impedes develo...

  11. Argentine ant invasion associated with loblolly pines in the southeastern United States: minimal impacts but seasonally sustained.

    Science.gov (United States)

    Rowles, Alexei D; Silverman, Jules

    2010-08-01

    Invasive ants are notorious for directly displacing native ant species. Although such impacts are associated with Argentine ant invasions (Linepithema humile) worldwide, impacts within natural habitat are less widely reported, particularly those affecting arboreal ant communities. Argentine ants were detected in North Carolina mixed pine-hardwood forest for the first time but were localized on and around loblolly pines (Pinus taeda), probably because of association with honeydew-producing Hemiptera. We explored the potential impacts of L. humile on arboreal and ground-foraging native ant species by comparing interspersed loblolly pines invaded and uninvaded by Argentine ants. Impacts on native ants were assessed monthly over 1 yr by counting ants in foraging trails on pine trunks and in surrounding plots using a concentric arrangement of pitfall traps at 1, 2, and 3 m from the base of each tree. Of floristics and habitat variables, higher soil moisture in invaded plots was the only difference between plot types, increasing confidence that any ant community differences were caused by Argentine ants. Overall patterns of impact were weak. Composition differed significantly between Argentine ant invaded and uninvaded trunks and pitfalls but was driven only by the presence of Argentine ants rather than any resulting compositional change in native ant species. Native ant abundance and richness were similarly unaffected by L. humile. However, the abundance of individual ant species was more variable. Although numbers of the arboreal Crematogaster ashmeadi (Myrmicinae) declined on and around invaded pines, epigeic Aphaenogaster rudis (Myrmicinae) remained the most abundant species in all plots. Argentine ant densities peaked in late summer and fall, therefore overlapping with most native ants. Unexpected was their continued presence during even the coldest months. We provide evidence that Argentine ants can invade and persist in native North Carolina forests, probably

  12. Training in radioprotection in the School of Pharmacy and Biochemistry, University of Buenos Aires

    International Nuclear Information System (INIS)

    The radioisotopes techniques have notably contributed to the advancement of knowledge in medicine and biomedicine during the last 60 years. The School of Pharmacy and Biochemistry of the University of Buenos Aires, Argentina, offers different Courses on methodology of radioisotopes in which the specialized knowledge on radioprotection is adapted to the following different groups: 1) A course for biochemistry students; 2) A course for physicians; 3) A course for graduates in biochemistry, biology, chemistry or other disciplines related to the health; 4) An up-dating course for licensed professionals; 5) A course for nuclear medicine technicians; and finally: 6) A course for Pharmacy students. The main objective of radiological protection teaching is specific and fitted to each level: the course (1) has been given (optional or mandatory) since 1960 for more than 7500 students. Part of the learning process in radioprotection is only informative, because in this case the students are not allowed to ask the Argentinean Nuclear Regulatory Authority authorization for radioactive material handling. Course (2) has been taken by more than 800 physicians since 1962. Here, the students receive a very intensive training in radioprotection which includes: justification, optimization and dose limits; dosimetric magnitudes and units; internal and external dosimetry of 99mTc, 201Tl, 60Co and other isotopes used in medicine; safety in occupational exposure; national and international legislation. Since 1962, more than 1000 graduates have attended course (3). In this case the training in radioprotection is as intensive as in course (2) with special focusing in 125I, 3H, 14C, 32P and other isotopes used in biomedicine. Course (4) has been given from 1992 and the objective is to up-date knowledge and the intensity of training depends on the requirements of each professional. Course (5) has been given since 1997 and it is mainly directed to the operational aspects of radioprotection for

  13. An alternative mechanism for radioprotection by dimethyl sulfoxide. Possible facilitation of DNA double-strand break repair

    International Nuclear Information System (INIS)

    The radioprotective effects of dimethyl sulfoxide (DMSO) have been known for many years, and the suppression of hydroxyl (OH) radicals induced by ionizing radiation has been thought to be the main cause of this effect. However, the DMSO concentration used was very high, and might be toxic, in earlier studies. In the present study, we administered a lower, non-toxic concentration (0.5%, id est (i.e.), 64 mM) of DMSO before irradiation and examined its radioprotective effects. Colony formation assay and micronucleus assay showed significant radioprotective effects in Chinese hamster ovary (CHO), but not in xrs5, which is defective in the repair function of DNA double-strand breaks. The levels of phosphorylated H2AX and the formation of 53BP1 foci 15 minutes after irradiation, which might reflect initial DNA double-strand breaks, in DMSO-treated CHO cells were similar to those in non-treated cells, suggesting that the radioprotective effects were not attributable to the suppression of general indirect action in the lower concentration of DMSO. On the other hand, 2 hours after irradiation, the average number of 53BP1 foci, which might reflect residual DNA double-strand breaks, was significantly decreased in DMSO-treated CHO cells compared to non-treated cells. The results indicated that low concentration of DMSO exerts radioprotective effects through the facilitation of DNA double-strand break repair rather than through the suppression of indirect action. (author)

  14. High-resolution stable isotope stratigraphy of the upper Cambrian and Ordovician in the Argentine Precordillera

    DEFF Research Database (Denmark)

    Sial, A.N.; Peralta, S.; Gaucher, C.;

    2013-01-01

    We report the occurrence of important carbon isotope excursions in early Paleozoic formations of the Eastern and Central Argentine Precordillera. The Steptoean positive isotope carbon excursion (SPICE) is known from North America, Kazakhstan, South China, Australia and South America, and the nega......We report the occurrence of important carbon isotope excursions in early Paleozoic formations of the Eastern and Central Argentine Precordillera. The Steptoean positive isotope carbon excursion (SPICE) is known from North America, Kazakhstan, South China, Australia and South America......, and the negative isotope carbon excursion (SNICE) has been described for the first time in South America. We report here the record of the SPICE and SNICE in a single section in the Eastern Precordillera. In the Central Precordillera, a minor middle Darriwilian positive carbon isotope excursion (MDICE) and a late...

  15. Order n.02-059 /P-RM of 05 juin 2002 setting up radioprotection et safety of ionizing radiation sources

    International Nuclear Information System (INIS)

    This order establishes the legal framework of radioprotection and safety of ionizing radiation sources in Mali. The scope as well as the definition of some main terms are given. The basis principles of radioprotection against ionizing radiation sources are defined. Instructions in uses of ionizing radiations, penal provisions are outlined

  16. How Argentine farmers overpowered Monsanto : the mobilization of knowledge-users and intellectual property regimes

    OpenAIRE

    Filomeno, Felipe Amin

    2013-01-01

    "Since the 1980s, governments and transnational corporations from core countries led by the United States have driven a global upward ratchet of intellectual property protection. In agriculture, this has meant strengthening the rights of seed companies over the plant varieties they develop and curtailing the rights of farmers over the seeds they cultivate. Exceptionally, from the 1990s to 2013, Argentine soy growers overcame the pressures from the seed industry, guaranteeing the right to free...

  17. Draft Genome Sequences of Four Enterococcus faecium Strains Isolated from Argentine Cheese

    Science.gov (United States)

    Martino, Gabriela P.; Quintana, Ingrid M.; Espariz, Martín; Blancato, Victor S.; Gallina Nizo, Gabriel; Esteban, Luis

    2016-01-01

    We report the draft genome sequences of four Enterococcus faecium strains isolated from Argentine regional cheeses. These strains were selected based on their technological properties, i.e., their ability to produce aroma compounds (diacetyl, acetoin, and 2,3-butanediol) from citrate. The goal of our study is to provide further genetic evidence for the rational selection of enterococci strains based on their pheno- and genotype in order to be used in cheese production. PMID:26847907

  18. Industry-Wide Work Rules and Productivity: Evidence from Argentine Union Contract Data

    OpenAIRE

    Lamarche, Carlos

    2013-01-01

    In the early 1990's, the Argentine government promoted a framework for productivity-based negotiations between firms and unions at low levels of organization. The policy weakened the industry-wide collective bargaining system, which sets working conditions for all firms in an industry. This paper employs newly developed quantile regression approaches to investigate the effect of union practices on productivity within the context of the reform. The findings show that (i) industry-wide practice...

  19. The executive and legislative branches and trade unions in the Argentine social security reform

    Directory of Open Access Journals (Sweden)

    Sidney Jard da Silva

    2007-01-01

    Full Text Available This article analyzes the interaction between organized labor and government during reform of the pension system in Argentina. The purpose is to investigate the political and institutional conditions favorable to the inclusion of trade unions in a negotiated pension reform process. The Argentine pattern of union-government interaction was shown to be shaped more by the peculiarities of the decision-making process than by the demands and power of union organizations.

  20. Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa

    OpenAIRE

    L.A Lozina; M.E Peichoto; S.I Boehringer; P. Koscinczuk; G.E Granero; O.C Acosta

    2010-01-01

    The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double-blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a topical placebo in the treatment of otitis externa. The propolis preparation and placebo were administrated into both external ear canals, twice daily for 14 days. Throughout the study, clinical examin...

  1. Quantitative analysis of the effects of the exotic Argentine ant on seed-dispersal mutualisms

    OpenAIRE

    Rodriguez-Cabal, Mariano A.; Stuble, Katharine L.; Nuñez, Martin A.; Sanders, Nathan J.

    2009-01-01

    Although it is increasingly clear that exotic invasive species affect seed-dispersal mutualisms, a synthetic examination of the effect of exotic invasive species on seed-dispersal mutualisms is lacking. Here, we review the impacts of the invasive Argentine ant (Linepithema humile) on seed dispersal. We found that sites with L. humile had 92 per cent fewer native ant seed dispersers than did sites where L. humile was absent. In addition, L. humile did not replace native seed dispersers, as rat...

  2. Uncertainty and Portfolio Dollarization. The Argentine Case in the Last Half Century

    OpenAIRE

    Tamara Burdisso; Eduardo Ariel Corso

    2011-01-01

    The aim of this document is to quantify the effects of uncertainty over financial assets dollarization of the Argentine non financial private sector. Our main concern is to illustrate to what extent uncertainty affects the degree of substitution between assets denominated in local and foreign currencies. Using the optimal portfolio selection theory combined with the multivariate GARCH methodology in order to estimate a model with heteroskedastic covariance matrix, we are able to estimate the ...

  3. International Financial Contagion: Evidence from the Argentine Crisis of 2001-2002

    OpenAIRE

    Boschi, Melisso

    2004-01-01

    The aim of this paper is to look for evidence of financial contagion suffered by several countries as a result of the latest Argentine crisis. I focus my attention on a set of countries: Brazil, Mexico, Russia, Turkey, Uruguay, and Venezuela. I also focus exclusively on three financial markets: foreign exchange, stock exchange, and sovereign debt. In order to test the hypothesis of contagion, Vector Autoregression (VAR) models and instantaneous correlation coefficients corrected for het...

  4. Managerial form, ownership and efficiency: a case-study of Argentine agriculture

    OpenAIRE

    Gallacher, Marcos; Goetz, Stephan J.; Debertin, David L.

    1994-01-01

    In agriculture, studies dealing with the separation of ownership from control have focused on sharecropping, paying little attention to the impact of management and ownership on efficiency. Using Argentine data, this study tests the hypothesis that efficiency is a function of type of management, concentration of ownership, and mechanisms for monitoring managers. Results show that management, ownership and monitoring have a greater impact on marketing efficiency than either on technical or cos...

  5. Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile)

    OpenAIRE

    Smith, Christopher D.; Zimin, Aleksey; Holt, Carson; Abouheif, Ehab; Benton, Richard; Cash, Elizabeth; Croset, Vincent; Currie, Cameron R; Elhaik, Eran; Elsik, Christine G.; Fave, Marie-Julie; Fernandes, Vilaiwan; Gadau, Jürgen; Gibson, Joshua D.; Graur, Dan

    2011-01-01

    Ants are some of the most abundant and familiar animals on Earth, and they play vital roles in most terrestrial ecosystems. Although all ants are eusocial, and display a variety of complex and fascinating behaviors, few genomic resources exist for them. Here, we report the draft genome sequence of a particularly widespread and well-studied species, the invasive Argentine ant (Linepithema humile), which was accomplished using a combination of 454 (Roche) and Illumina sequencing and community-b...

  6. Proceedings of the 76. meeting of the Argentine Physics Association (AFA). V.3

    International Nuclear Information System (INIS)

    Works are presented at the 76 Annual meeting of the Argentine Physics Association. The papers can be grouped under the following main topics: teaching, history and philosophy of physics, mathematical methods, classical and quantum physics, mechanics and fields, statistical physics and thermodynamics, elementary particle physics and fields, nuclear physics, and molecular physics, atomic collisions, optics, fluid dynamics and plasmas, condensed matter, instrumentation, geophysics, astronomy and astrophysics. refs., ills

  7. Food habits of the great horned owl in northwestern Argentine Patagonia: the role of introduced lagomorphs

    OpenAIRE

    Donázar, José A.; Travaini, Alejandro; Ceballos, Olga; Delibes, M.; Hiraldo, F.

    1997-01-01

    —Pellets of adult and nestling Great Horned Owls (Bitho tirginianus) were collected at 12 owl territories nearJunin de los Andes (Neuquen, Argentine Patagonia) during the breeding seasons of 1991— 92 and 1994—95. Mammals represented 69% of the total prey items (N = 1324) identified and Reithrodon auritus (16%), Lepuseuwpaeus (12%) and Ctenomys haigi (12%) were the most common species. Anhropods aecounted for 27% of the total prey by numbers. The two main prey items b...

  8. Quality assurance programmes and normalization for the Argentine-Brazilian integration

    International Nuclear Information System (INIS)

    Within the frame of the tasks developed by the Argentine-Brazilian Contractors Coordination Committee in the nuclear area, which was at the beginning promoted by the Contractor Committee of the Argentine Association of Nuclear Technology, a working team was created between both countries in order to analyze the existing regulations and the Quality Assurance systems applied in Brazil and Argentina for their nuclear projects. This paper describes the steps to be followed so as to fulfill the compatibility of the rules, quality assurance and firm certification, laboratories, personnel and materials, and the applicable quality assurance programmes. At first, the methodology applied was the collection of the information and the existing regulations in each one of the countries, to exchange them, analyze them and arrange joint meetings and organize a seminar with experts from both countries to develop and discuss the objectives of this working team. As a result of these activities, the criteria adopted will allow, together with another actions, that both Argentine and Brazilian firms make exchanges and integrations in the nuclear field to supply Atucha II and Angra II. (Author)

  9. Radioprotection of sensitive rat tissues by oligoelements Se, Zn, Mn plus lachesis muta venom

    International Nuclear Information System (INIS)

    In this study we first evaluated the general radioprotective efficacy of Se, Zn and Mn (4 μg/ml each) plus Lachesis muta venom (4 ng/ml) combination (O-LM) by determining survival on rats irradiated with lethal doses of gamma-rays. The aim of the second part of the study was to investigate the O-LM ability to prevent ionizing radiation-induced damage on small intestine, bone marrow and submandibular glands. Hence, histological characteristics and functional studies, together with proliferation and apoptotic marker levels on whole body irradiated rats with a 5 Gy dose were evaluated. Results show that all animals of the untreated group died after whole body irradiation with 8 and 10 Gy while 60 day-survival was more than 80% and 40% in O-LM-treated animals, respectively. Histopathological examinations revealed a high degree of small intestine and submandibular gland radioprotection 3 days post-irradiation. O-LM inhibited histological damage on small intestine, restoring the radiation-induced reduction in villous height and crypt number. O-LM prevented radiation-induced loss of salivary gland function and morphological alterations. These effects were associated to a complete inhibition of radiation-induced apoptosis. Furthermore, studies performed 30 days post-irradiation revealed that O-LM significantly improved bone marrow repopulation, increasing all medullar progenies to the extent of the non-irradiated animals, and completely prevented permanent submandibular gland alterations. Based on the present results and taking into account that O-LM is being safely administered in phase I clinical trial as an immunomodulator, we conclude that O-LM is a non-toxic promising approach to achieve radioprotection for patients undergoing radiotherapy. (author)

  10. Radioprotective Effect of Moderate Wine Consumption in Patients With Breast Carcinoma

    International Nuclear Information System (INIS)

    Purpose: Given the high cost and side effects of radioprotective agents such as amifostine, attention has been focused on potentially equally effective but less expensive and toxic natural substances. We evaluated the potential radioprotective effects of wine in preventing skin toxicity in patients with breast cancer. Methods and Materials: Before treatment, the medical history and habits of patients were assessed and the information recorded in their clinical folders. Patients were divided into three groups based on the dose/fractionation scheme used: control group, 60.4 Gy (standard technique); Modulated Accelerated Radiotherapy in Adjuvant treatment of breast cancer (MARA)-1 protocol group, 44 Gy (concomitant boost to tumoral bed); and MARA-2 protocol group, 60 Gy (concomitant boost to tumoral bed). The impact of the following variables on acute skin toxicity was evaluated by chart review: radiotherapy protocol, planning target volume (PTV), comorbidity (e.g., hypertension and diabetes), hemoglobin level before therapy, adjuvant hormone therapy, adjuvant chemotherapy, cigarette smoking, and drinking habits. Results: The study population consisted of 348 patients. More severe skin toxicity was significantly associated with the radiotherapy protocol (p < 0.001) and median PTV (p = 0.005). In addition, the incidence of acute toxicity of Grade 2 or greater was higher in patients without alcohol intake (38.4% vs. 22.3%, p = 0.021). The daily amount of alcohol intake also influenced the incidence of skin toxicity, with an incidence of 38.4% in patients with no wine intake, 31.8% in patients drinking half a glass per day, 13.6% in patients drinking one glass per day, and 35.0% in patients drinking two glasses per day. Multivariate analysis showed that wine intake, PTV, and radiotherapy protocol were all significantly correlated with acute toxicity. Conclusions: Our results indicate that wine may have a radioprotective effect; however, prospective studies are needed to

  11. Clinical study of the radioprotective effects of Amifostine (YM-08310, WR-2721) on chronic radiation injury

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, I.; Nagai, T.; Miyaishi, K.; Maehara, Y.; Niibe, H.

    1986-06-01

    We have previously reported that Amifostine, a radioprotective agent, was effective in treating acute radiation mucositis in the head and neck region. We found that when a considerable amount of Amifostine accumulates in the salivary glands, it may be useful in preventing chronic disturbances of salivary secretion. We have observed an increase in the uptake of Ga-67-citrate to the salivary glands when they were irradiated. In this paper, the radioprotective effects of Amifostine, in treating chronic radiation injury of the salivary glands, were studied, using the cessation of an increase in uptake of Ga-67-citrate after radiotherapy as the criterion. The subjects were 105 patients, (280 salivary glands in Ga-scintigrams) with malignancy of the head and neck region treated by irradiation from 1978 to 1984. Ga-negative glands were recognized in 97%, that is, 36 out of 37 glands, before irradiation, and the figure decreased to 19%, seven out of 37, within 1 to 2 weeks (10Gy less than or equal to) after the start of radiotherapy. In patients who were irradiated with more than 30 Gy and in whom scintigraphy was performed at 6 months or more after radiotherapy, Ga-negative glands were recognized in 18 out of 41 glands, 44%, with Amifostine, compared with 13%, four out of 32 glands, without Amifostine. A difference was recognized between these two groups in the negative change in Ga-67 uptake after radiotherapy (p less than 0.05). These facts suggest that Amifostine may have a radioprotective effect on chronic radiation injury.

  12. The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats

    International Nuclear Information System (INIS)

    There is a controversy regarding the effects of the analogues of the gonadotrophin-releasing hormone (GnRH) in radiotherapy. This has led us to study the possible radio-protection of the ovarian function of a GnRH agonist analogue (GnRHa), triptorelin, in adult, female rats (Rattus norvegicus sp.). The effects of the X-irradiation on the oocytes of ovarian primordial follicles, with and without GnRHa treatment, were compared, directly in the female rats (F0) with reproductive parameters, and in the somatic cells of the resulting foetuses (F1) with cytogenetical parameters. In order to do this, the ovaries and uteri from 82 females were extracted for the reproductive analysis and 236 foetuses were obtained for cytogenetical analysis. The cytogenetical study was based on the data from 22,151 metaphases analysed. The cytogenetical parameters analysed to assess the existence of chromosomal instability were the number of aberrant metaphases (2234) and the number (2854) and type of structural chromosomal aberrations, including gaps and breaks. Concerning the reproductive analysis of the ovaries and the uteri, the parameters analysed were the number of corpora lutea, implantations, implantation losses and foetuses. Triptorelin confers radio-protection of the ovaries in front of chromosomal instability, which is different, with respect to the single and fractioned dose. The cytogenetical analysis shows a general decrease in most of the parameters of the triptorelin-treated groups, with respect to their controls, and some of these differences were considered to be statistically significant. The reproductive analysis indicates that there is also radio-protection by the agonist, although minor to the cytogenetical one. Only some of the analysed parameters show a statistically significant decrease in the triptorelin-treated groups.

  13. Normal-tissue radioprotection by overexpression of the copper-zinc and manganese superoxide dismutase genes

    Energy Technology Data Exchange (ETDEWEB)

    Veldwijk, Marlon R. [Dept. of Radiation Oncology, Univ. Medical Center Mannheim, Univ. of Heidelberg, Mannheim (Germany); Pharmacology of Cancer Treatment (G402), German Cancer Research Center, Heidelberg (Germany); Herskind, Carsten; Wenz, Frederik [Dept. of Radiation Oncology, Univ. Medical Center Mannheim, Univ. of Heidelberg, Mannheim (Germany); Sellner, Leopold; Zeller, W. Jens [Pharmacology of Cancer Treatment (G402), German Cancer Research Center, Heidelberg (Germany); Radujkovic, Aleksandar [Dept. of Internal Medicine V, Univ. of Heidelberg (Germany); Laufs, Stephanie [Dept. of Experimental Surgery, Univ. Medical Center Mannheim, Univ. of Heidelberg, Mannheim (Germany); Molecular Oncology of Solid Tumors (G360), German Cancer Research Center, Heidelberg (Germany); Fruehauf, Stefan [Center for Tumor Diagnostic and Therapy, Paracelsus-Klinik, Osnabrueck (Germany)

    2009-08-15

    Background and Purpose: Protection of normal tissue against radiation-induced damage may increase the therapeutic ratio of radiotherapy. A promising strategy for testing this approach is gene therapy-mediated overexpression of the copper-zinc (CuZnSOD) or manganese superoxide dismutase (MnSOD) using recombinant adeno-associated viral (rAAV2) vectors. The purpose of this study was to test the modulating effects of the SOD genes on human primary lung fibroblasts (HPLF) after irradiation. Material and Methods: HPLF were transduced with rAAV2 vectors containing cDNA for the CuZnSOD, MnSOD or a control gene. The cells were irradiated (1-6 Gy), and gene transfer efficiency, apoptosis, protein expression/activity, and radiosensitivity measured by the colony-forming assay determined. Results: After transduction, 90.0% {+-} 6.4% of the cells expressed the transgene. A significant fivefold overexpression of both SOD was confirmed by an SOD activity assay (control: 21.1 {+-} 12.6, CuZnSOD: 95.1 {+-} 17.1, MnSOD: 108.5 {+-} 36.0 U SOD/mg protein) and immunohistochemistry. CuZnSOD and MnSOD overexpression resulted in a significant radioprotection of HPLF compared to controls (surviving fraction [SF] ratio SOD/control > 1): CuZnSOD: 1.18-fold (95% confidence interval [CI]: 1.06-1.32; p = 0.005), MnSOD: 1.23-fold (95% CI: 1.07-1.43; p = 0.01). Conclusion: Overexpression of CuZnSOD and MnSOD in HPLF mediated an increase in clonogenic survival after irradiation compared to controls. In previous works, a lack of radioprotection in SOD-overexpressing tumor cells was observed. Therefore, the present results suggest that rAAV2 vectors are promising tools for the delivery of radioprotective genes in normal tissue. (orig.)

  14. Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer

    International Nuclear Information System (INIS)

    Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, suggesting that the radioprotective effect was mediated by enhanced DNA damage repair. Shortly after DPS injection, significant cell cycle arrest was observed in CECs at both G1/S and G2/M checkpoints, which was accompanied by the activation of cell cycle inhibitors p21 and growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A). Further investigation revealed that DPS activated ataxia telangiectasia mutated (ATM), an important inducer of DNA damage repair and cell cycle arrest. Conclusions: DPS selectively radioprotected normal intestinal CECs and sensitized prostate cancer cells in a clinically relevant model. This effect may be, at least in part, mediated by DNA damage response activation and has the potential to significantly increase the therapeutic index of radiation therapy

  15. Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A

    Directory of Open Access Journals (Sweden)

    Arti Patel

    2013-01-01

    Full Text Available Objectives: The present study was undertaken to evaluate the radioprotective and cytoprotective potential of cordifolioside-A, a primary active constituent of n-butanol fraction of Tinospora Cordifolia (NBTC against 4 Gy-γ radiation in mice and cyclophosphamide induced genotoxicity. Materials and Methods: Presence of cordifolioside-A in NBTC stem ethanolic extract was confirmed by high performance thin layer chromatography (HPTLC analysis. Radioprotective activity was evaluated at 80 and 120 mg/kg, intraperitoneal (i.p. dose of NBTC administered 15 days prior to whole body radiation exposure by observing survival rate, change in body weight, hematology, spleen colony forming unit (CFU, and micronucleus (MN expression. Cytoprotective activity of NBTC was evaluated at 5, 10, and 15 mg/ml concentrations on Allium cepa root meristem growth against cyclophosphamide. Results: HPTLC analysis of standard cordifolioside A, and NBTC confirmed the presence of cordifolioside-A in NBTC with the retention factor value of 0.86. Administration of NBTC (120 mg/kg, i.p. produced significant protection against radiation in terms of increased survival rate, body weight retention, hematological parameters, spleen CFU assay (P < 0.01, and decreased MN expression (P < 0.01. Cytoprotectivity was observed maximally at 10 mg/ml NBTC concentration with significant increase in root growth (P < 0.01, non-toxic mitotic index (MI (65.9% and lesser chromosomal aberrations (15.4%. NBTC at 10 mg/ml concentration showed very few C-anaphase compared to aberrations like fragmentation, C-anaphase, multipolarity and sticky chromosome in cyclophosphamide alone. Conclusion: The results suggest that enriched NBTC containing cordifolioside-A has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.

  16. Radiation effects and radioprotection by Thai medicinal plants in mouse macrophage cell line

    Institute of Scientific and Technical Information of China (English)

    Cheeraratana Cheeramakara; Kriyaporn Songmueng; Wanyarat Nakosiri; Montri Chairojana; Arag Vitittheeranon; Nopchai Suthisai; Nongnuch Jangsawang; Channarong Sanghiran; Apichart Nontprasert

    2009-01-01

    Objective:To investigate the effects of radiation on growth-arrested (GA)and micronucleus-production (MP) rates,and the radioprotective properties of Thai medicinal plants in mouse macrophage cell line RAW264.7 in vitro.Methods:Mouse macrophage cell line (RAW264.7)was cultured in vitro.Various radiation expo-sures,growth-arrested rate assay,micronucleus production assay,and radioprotection by Thai medicinal plants were performed.Results:The results showed that GA and MP rates for γ-rays and UV were dose-dependent. The 50%-affected dose of γand UV radiation for the GA rate was 10 Gy and 159 microwatt/cm2 for 0.5 sec-onds,respectively.After X-ray exposure,there was no apparent effect on RAW264.7 cells,even with a forty-fold human diagnostic dose.Two exposures to γradiation at 20 Gy resulted in a significantly higher MP rate than 20 Gy single exposure or control (P <0.05).The Thai medicinal plants (Kamin-chun capsules,Curcu-ma longa Linn;Hed lingeu,Ganoderma lucidum;Ya Pakking capsule,Murdannia loriformis)could not pre-vent cell damage,but epigallocatechin gallate and L-cysteine could provide protection from 2 Gy γ-ray expo-sure.Conclusion:γradiation caused chromosomal damage during cell division and UV caused cell death, while X-ray radiation was safe.The radioprotective effects of Thai medicinal plants,Kamin-chun,Hed lingeu, and Ya Pakking,could not prevent cell damage in this study.

  17. Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Junqiang; Doi, Hiroshi [Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, California (United States); Saar, Matthias; Santos, Jennifer [Department of Urology, School of Medicine, Stanford University, Stanford, California (United States); Li, Xuejun; Peehl, Donna M. [Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, California (United States); Knox, Susan J., E-mail: sknox@stanford.edu [Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, California (United States)

    2013-12-01

    Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, suggesting that the radioprotective effect was mediated by enhanced DNA damage repair. Shortly after DPS injection, significant cell cycle arrest was observed in CECs at both G1/S and G2/M checkpoints, which was accompanied by the activation of cell cycle inhibitors p21 and growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A). Further investigation revealed that DPS activated ataxia telangiectasia mutated (ATM), an important inducer of DNA damage repair and cell cycle arrest. Conclusions: DPS selectively radioprotected normal intestinal CECs and sensitized prostate cancer cells in a clinically relevant model. This effect may be, at least in part, mediated by DNA damage response activation and has the potential to significantly increase the therapeutic index of radiation therapy.

  18. The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats

    Energy Technology Data Exchange (ETDEWEB)

    Camats, N. [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, F. [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, J.J. [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, 30120 El Palmar, Murcia (Spain); Calaf, J. [Servei de Ginecologia i Obstetricia, Hospital Universitari de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Martin-Mateo, M. [Departament de Pediatria, d' Obstetricia i Ginecologia i de Medicina Preventiva, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Caldes, M. Garcia, E-mail: Montserrat.Garcia.Caldes@uab.es [Institut de Biotecnologia i de Biomedicina (I.B.B.), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)

    2009-10-02

    There is a controversy regarding the effects of the analogues of the gonadotrophin-releasing hormone (GnRH) in radiotherapy. This has led us to study the possible radio-protection of the ovarian function of a GnRH agonist analogue (GnRHa), triptorelin, in adult, female rats (Rattus norvegicus sp.). The effects of the X-irradiation on the oocytes of ovarian primordial follicles, with and without GnRHa treatment, were compared, directly in the female rats (F{sub 0}) with reproductive parameters, and in the somatic cells of the resulting foetuses (F{sub 1}) with cytogenetical parameters. In order to do this, the ovaries and uteri from 82 females were extracted for the reproductive analysis and 236 foetuses were obtained for cytogenetical analysis. The cytogenetical study was based on the data from 22,151 metaphases analysed. The cytogenetical parameters analysed to assess the existence of chromosomal instability were the number of aberrant metaphases (2234) and the number (2854) and type of structural chromosomal aberrations, including gaps and breaks. Concerning the reproductive analysis of the ovaries and the uteri, the parameters analysed were the number of corpora lutea, implantations, implantation losses and foetuses. Triptorelin confers radio-protection of the ovaries in front of chromosomal instability, which is different, with respect to the single and fractioned dose. The cytogenetical analysis shows a general decrease in most of the parameters of the triptorelin-treated groups, with respect to their controls, and some of these differences were considered to be statistically significant. The reproductive analysis indicates that there is also radio-protection by the agonist, although minor to the cytogenetical one. Only some of the analysed parameters show a statistically significant decrease in the triptorelin-treated groups.

  19. Society of Reproductive Surgeons

    Science.gov (United States)

    The Society of Reproductive Surgeons Home About Us About SRS Mission Statement Officers The Role of Reproductive Surgeons For ... Fact Sheets and Booklets SRS is an affiliated society to the American Society for Reproductive Medicine . Below ...

  20. Influence of different irradiation facilities on the response of radioprotection devices

    International Nuclear Information System (INIS)

    An EIC 1 extrapolation chamber, flushed with a methan based tissue equivalent gas is presented. This measuring device serves as a reference instrument to calibrate in tissue absorbed dose beta beams from different irradiation facilities; point radioactive sources, sources used with beam flattening filters, large area sources simulated by moving a point source. The source to detector distance has to be greater than 3 cm, requiring a transfer dosemeter for smaller distances. Influence of these different irradiation geometries has been studied on several radioprotection instruments (babyline, individual dosemeter, ionisation chamber), using three radionucleides: 147Pm, 204Tl, 90Sr + 90Y

  1. Radioprotective effect of calcium channel antagonist nifedipine on rat lungs following thoracic X-ray irradiation

    International Nuclear Information System (INIS)

    Nifedipine was administered to rats following 18 Gy thoracic irradiation. Compared with the rats subjected to irradiation alone, in rats administered nifedipine after irradiation, although there was no difference in the phospholipid contents in lung lavage fluid and in the number of type 2 pneumocytes, the survival rate within 30 days and body weight increased, lung weight decreased, in lung lavage fluid the macrophages increased and the neutrophils decreased in number, and pathological changes in lung abated. These results indicated that nifedipine had marked radioprotective effect on rat lungs following thoracic X-ray irradiation. The possible mechanism of the effect is discussed

  2. Environmental control and radioprotection in Itataia and Lagoa Real uranium mines

    International Nuclear Information System (INIS)

    Monitoring Programs in Itataia and Lagoa Real uranium mines were initiated in 1982. In the actual pre-operational phase of this Programs, are being collected samples of air, surface and underground waters, stream sediments, soil, field products, and milk. Environmental contamination of air is controlled by thermoluminescent dosimeters, distributed around the mines. Instantaneous radiation measures in this stations are made with scintillometer calibrated in Radioprotection Laboratory Department-CDTN. Photographic dosimeters are used for monitoring external radiation exposures in workers. Radiation levels evaluation, air and surface contamination measures, were effectuated in installations, trenches, and research galleries. Another factors which are now being studied: climate, meteorology, and hidrology. (author)

  3. Response and Monte Carlo evaluation of a reference ionization chamber for radioprotection level at calibration laboratories

    Science.gov (United States)

    Neves, Lucio P.; Vivolo, Vitor; Perini, Ana P.; Caldas, Linda V. E.

    2015-07-01

    A special parallel plate ionization chamber, inserted in a slab phantom for the personal dose equivalent Hp(10) determination, was developed and characterized in this work. This ionization chamber has collecting electrodes and window made of graphite, and the walls and phantom made of PMMA. The tests comprise experimental evaluation following international standards and Monte Carlo simulations, employing the PENELOPE code to evaluate the design of this new dosimeter. The experimental tests were conducted employing the radioprotection level quality N-60 established at the IPEN, and all results were within the recommended standards.

  4. Cation-anionicpalladium Complexes- New Types of Antitumor, Immune Response-modulating and Radioprotective Agents

    Institute of Scientific and Technical Information of China (English)

    EFIMENKO I. A.; SHISHILOV O. N.; IVANOVA N. A.; EROFEEVA O. S.

    2012-01-01

    Here we report results of our investigations of new class of bioactive palladium compounds (AHn)m[PdC14],which were discovered as a result of systematic study of correlations between composition,structure and bioactivity of different types of platinum metals coordination compounds.For the first time we demonstrated in vivoa possibility of development of palladium compounds,which exceed cisplatin in antitumor activity and do not show immunosuppressive effects,and palladium compounds with immunostimulating and radioprotective activities.Combinations of cytostatic agents or radiation with palladium complexes lead to significant synergism of their activities and high therapeutic efficiency exceeded an efficiency of their separated use.

  5. Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group

    International Nuclear Information System (INIS)

    Some compounds of the 5 thione imidazolidines group were synthesized by conventional or original methods, and this study is aimed at defining certain pharmacodynamic properties which these substances may be expected to show on the basis of their structure. The properties looked for are: - antithyroid activity, by studying the difference in iodine 131 fixation by the thyroid of rats previously treated or not with these materials; - radioprotective activity, by the comparative study of percentage survival; after 30 days, of mice subjected to a lethal dose of X radiation and having received or not, before irradiation, an intraperitoneal injection of the product under investigation. (author)

  6. Opinion of the IRSN on French electronuclear stock safety and radioprotection in 2009

    International Nuclear Information System (INIS)

    In its first part, this annual report presents the main trends which emerge after a global examination of nuclear safety and radioprotection of the operated nuclear power plants in France during 2009. The second part reports, comments and discusses events which occurred in 2009 and are considered as important as far as safety is concerned. The third part deals with generic anomalies, i.e. those affecting several nuclear plants. The fourth part discusses significant evolutions implemented or planned by EDF, whether they are modifications or arrangements in plant operation aimed at treating safety issues, but also economic constraints

  7. Radiosensitivity of marrow stromal cells and the effect of some radioprotective agents

    International Nuclear Information System (INIS)

    The results showed that marrow stromal cells include fibroblasts, reticular cells, macrophages and adipocytes. The capability of the adherent layer derived from marrow cells of 2 mouse femurs to support hematopoietic stem cells was stronger than those of layers derived from 0.5 or 1 mouse femurs. The radiosensitivity of bone marrow stromal cells was lower than that of hematopoietic stem cells. The radioprotective effect of AET and PLP (polysaccharide of Lobaria Pulmonaria Hoffm) on the bone marrow stromal cells and their capability to support hematopoietic stem cells was clearly demonstrated

  8. Public involvement in the decision making process, Argentine experience

    International Nuclear Information System (INIS)

    In the frame of a young participative democracy the Comision Nacional de Energia Atomica (C.N.E.A.), technical and legal responsible for radioactive waste management, is developing a plan for the close out of tailings facilities from past mining and milling operations and the environmental restoration of nine different sites in six provinces all over the country. In the first site, Malargue Facility, different activities have been developed promoting public involvement in the decision making process. The lessons learned and the experience acquired have given the background for the systematization of public consultation in the ongoing and future stages of the plan. Malargue's experience in this field will be analyzed stressing on different aspects considered of importance for the design of a communicational strategy adapted to the characteristics of a society without experience in this field. The influence of public concern on conservative bias of technical decisions will be evaluated. (author)

  9. Interspecies comparison of the tissue distribution of WR-2721, a radioprotective drug

    International Nuclear Information System (INIS)

    Pre-irradiation intravenous administration of the radioprotective drug S-2-[3-aminopropylamino]ethylphosphorothioic acid (WR-2721) has potential value in radiotherapy because it doubles the radiation resistance of normal mouse tissues while affording only minimal protection to tumors. Deficient deposition of WR- 2721 in tumor tissue has recently been demonstrated and this is thought to be a major reason for the preferential protection of normal tissues by the drug. Data originally obtained in studies using the mouse and rat indicated that the tissue distribution of WR-2721 was possibly more closely related to dose per unit surface area than to dose per unit weight. To test this hypothesis an interspecies comparison of the tissue distribution of 35S-labeled WR-2721 was carried out in normal mice, rats, rabbits, and dogs at 15 and 30 minutes after intravenous administration. Results suggest that the surface area and body weight exert equal effects on the tissue concentration of WR-2721. The results further suggest that lower absolute doses of WR-2721 in the human, possibly as low as 20 mg/kg, may provide a radioprotective effect equivalent to that produced from 100 mg/kg in the mouse, i.e., a 50 to 80 percent increase in radiation resistance (CH)

  10. A radioprotective effect of imatinib (Gleevec {sup registered}) in human squamous carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Bartkowiak, D.; Hipp, P.R.; Roettinger, E.M. [University Hospital Ulm (Germany). Dept. of Radiooncology; Mendonca, M.S. [IU School of Medicine, Indianapolis, IN (United States). Dept. of Radiation Oncology, Radiation and Cancer Biology Lab.

    2007-08-15

    Purpose: To study the radiation response-modifying effect of imatinib (Gleevec {sup registered}) in a squamous cell carcinoma line, PECA. Patients and Methods: Cytotoxicity was determined by colony forming and multiplying capacity. Drug stability was shown by HPLC. Multidrug resistance phenotype was studied by rhodamine-123 efflux. Cell-cycle responses were measured by flow cytometry. Homologous recombination repair was determined by Rad51 immunohistochemistry. Results: Inactivating 50% of the PECA cells required approximately 7 {mu}M imatinib. The drug did not decay nor was it degraded during test periods. Drug efflux occurred only to a minor extent. Multiplying capacity but not survival fractions revealed a radioprotective effect of imatinib. There were only minor cell-cycle alterations in the presence of imatinib but the rate of Rad51-positive repair foci was significantly increased. Conclusion: PECA cells apparently lack a highly specific target for imatinib. In cells surviving at high drug concentrations, imatinib may exert a radioprotective effect on multiplying capacity by inducing DNA repair. Under prolonged exposure, drug-resistant cells may show an accelerated recovery from acute or delayed radiation damage. (orig.)

  11. Evaluation of radioprotective properties of chlorophyllin against the gamma-rays

    International Nuclear Information System (INIS)

    Several decades ago it had been demonstrated that chlorophyllin, and its water soluble derivates, such as chlorophyllin, have therapeutic values. recently an antimutagenic activity has been observed in several tests. The aim of this work is to investigate if chlorophyllin has some radioprotective effect when the organisms are exposed to gamma-rays. The somatic mutation and recombination test in drosophila was used. This test allows us to detect simultaneously both genetic mutation, chromosomal aberration and mitotic recombination. The conduction of the experiment involved four treatments: 1) 5% sucrose, 2) 5% chlorophyllin, 3) 5% sucrose +20Gyγrays 4) 5% chlorophyllin +20Gyγrays. All the treatments lasted 24 hours and three replicas were performed. The data obtained showed a significant decrease in spot frequency found in the treatment with chlorophyllin and γ rays. From the results we are to conclude that the chlorophyllin has a radioprotective effect, when the drosophila larvae are irradiated with 20 Gy OF γrays. Mitotic recombination was affected in the same way and it is important because genetic recombination process are related to cancer induction. (Author)

  12. Radioprotection: Effects of nutritional factors on endogenous protective enzymes and survival of irradiated mice

    International Nuclear Information System (INIS)

    The nutritional relationship of vitamin E and selenium, with respect to their antioxidant activities, may be related in part to glutathione peroxidase activity and related enzymatic pathways. Previous studies in the authors' laboratory have indicated that protection or induction of glutathione peroxidase activity may have a role in radioprotection. In the present studies, CD2F1 male mice were given increased amounts of Fe and/or Zn in their drinking water (50% or 100% above normal dietary levels). In general, increased intake of these minerals resulted in protection against weight loss and increased survival, including improved Kaluszyner survival coefficients calculated 30 days after 800 or 850 rad exposures. There is little difference in the results between the treated groups. No changes in the glutathione peroxidase or catalase activities in tissues were observed when either Zn or Fe were added to the diet. The addition of three times the normal level of vitamin E to the diet did not improve the results of the treatments where increases in Zn, Fe or both were given. Additional studies are in progress to determine the combination of vitamins and minerals that will provide the best radioprotection and to determine the biochemical basis for increased protection

  13. Radioprotection during the diagnostic use of X-ray in western Europe

    International Nuclear Information System (INIS)

    The speed-up of technical progress in the field of radiodiagnosis has led to a huge expansion of this technique. The number of acts per year per inhabitant is rising constantly in industrialised countries. The average population dose has already doubled natural irradiation in certain cases. Considering the established effects on carcinogenesis and heredity the need for restrictive measures can no longer be ignored. Exposed staff are safeguarded by international recommendations, largely incorporated into national legislations. The protection of patients against superfluous irradiations, while nevertheless essential, is still neglected. The means are not lacking and must certainly be developed, but above all employed properly. Medical irradiation can be limited to a considerable extent by checking the competence of X-ray source users, systematically using the possibities of the equipment in such a way as to reduce the doses delivered and keeping an irradiation book for patients. Everyone agrees that a 90% reduction of medical irradiation would in no way impair the quality of the examinations. The following points are developed particularly: institutional organisation of radioprotection; aims of radioprotection in the context of the diagnostic use of X-rays; present reference norms in radiodiagnosis; doses delivered during conventional radiodiagnostic examinations

  14. Radioprotective effect of chicory seeds against genotoxicity induced by ionizing radiation in human normal lymphocytes.

    Science.gov (United States)

    Hosseinimehr, S J; Ghaffari-Rad, V; Rostamnezhad, M; Ghasemi, A; Allahverdi Pourfallah, T; Shahani, S

    2015-01-01

    The search for less-toxic radioprotective agents has led to a growing trend towards natural products. Protective effect of the methanolic extract of chicory seeds (MCS) was investigated against genotoxicity induced by ionizing radiation in human lymphocytes. Human peripheral blood samples were collected and incubated with MCS at different concentrations (10, 50, 100, and 200 μg/mL) for two hours. The whole blood samples were exposed in vitro to X-ray at dose 2.5 Gy. Then, the lymphocytes were cultured with mitogenic stimulation to determine the micronucleus in cytokinesis blocked binucleated cell. The methanolic extract at all doses significantly reduced the frequency of micronuclei in binucleated lymphocytes, as compared with similarly irradiated lymphocytes without any extract treatment. The maximum protection was observed at 200 μg/mL of MCS, it completely protected genotoxicity induced by ionizing radiation in human lymphocytes. The extract exhibited a concentration-dependent radical scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals. HPLC analysis of MCS showed this extract is containing chlorogenic acid as a phenolic compound. These data suggest that the radioprotective effect of methanolic extract of chicory seeds can be attributed to the presence of phenolic compounds such as chlorogenic acid which act as antioxidant agents. PMID:26278267

  15. Radioprotective effect of vitamin E in parotid glands: a morphometric analysis in rats

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the radioprotective effect of vitamin E on rat parotid glands by morphometric analysis. Sixty male rats were divided into 5 groups (n=6): control, in which animals received olive oil solution; olive oil/irradiated, in which animals received olive oil and were irradiated with a dose of 15 Gy of gamma radiation; irradiated, in which animals were irradiated with a dose of 15 Gy gamma radiation; vitamin E, which received α-tocopherol acetate solution; vitamin E/irradiated, which received α-tocopherol acetate solution before irradiation with a dose of 15 Gy gamma rays. Half of the animals were euthanized at 8 h, and the remaining at 30 days after irradiation. Both parotid glands were surgically removed and morphometric analysis of acinar cells was performed. Data were subjected to two-way ANOVA and Tukey's test (α=0.05). Morphometric analysis showed a significant reduction in the number of parotid acinar cells at 30 days in olive oil/irradiated and irradiated groups. In groups evaluated over time a significant reduction was shown at 30 days in olive oil/irradiated and irradiated groups, indicating that ionizing radiation caused tissue damage. The vitamin E/irradiated group presented more acinar cells than the irradiated group, but no statistically significant difference was observed (p>0.05). In conclusion, vitamin E seems to have failed as a radioprotective agent on acinar cells in rat parotid glands. (author)

  16. Isolation and identification of radioprotective compound (s) from radioresistant culture of Fusarium Moniliforme

    International Nuclear Information System (INIS)

    Mat extract and filtrate of the radio-resistant strain Fusarium Moniliforme have been prepared and tested for their radioprotective action on the radiosensitive strain Trichoderma Viride. Both extracts gave T. Viride a protective effect against gamma radiation. Analysis of mat extracts and filtrates of both fungi, the radioresistant F. Moniliforme and the radiosensitive T. Viride revealed a pronounced differences in amino acids quantities in addition to the presence of gibberelic acid (GA3) in the filtrate of F. Moniliforme only. Generally, the radioresistant fungus F. Moniliforme was able to accumulate ten amino acids in large quantity than the radiosensitive one. These amino acids comprised, cystine, glutamic acid, serine, methionine, histidine, proline, arginine, alanine, glycine and therionine. The amino acid pool of both fungi was poor in filtrate than in the mat extract. Analysis of filtration of F. Moniliforme was characterized by high content of gibberellic acid, whereas, only traces were detected in mat extract. No gibberellic acid was detected in both mat extract and filtrate of T. Viride. The results of this investigation, revealed also that both amino acids and gibberellic acid were subjected to pronounced disturbances following irradiation compared with the control. A close correlation between the induced radioresistance of T. Viride and the amounts of amino acids and G A, added to its culture medium was observed, suggesting their participation in radioprotection

  17. Radioprotective effect of vitamin E in parotid glands: a morphometric analysis in rats

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Carolina Cintra; Boscolo, Frab Norberto; Almeida, Solange Maria de [Universidade Estadual de Campinas (UNICAMP), Piracicaba, SP (Brazil). Dept. de Diagnostico Oral; Ramos-Perez, Flavia Maria de Moraes; Perez, Danyel Elias da Cruz, E-mail: flavia.ramosperez@ufpe.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Clinica e Odontologia Preventiva; Novaes, Pedro Duarte [Universidade Estadual de Campinas (UNICAMP), Piracicaba, SP (Brazil). Escola de Odontologia. Dept. de Morfologia

    2013-11-01

    The aim of this study was to evaluate the radioprotective effect of vitamin E on rat parotid glands by morphometric analysis. Sixty male rats were divided into 5 groups (n=6): control, in which animals received olive oil solution; olive oil/irradiated, in which animals received olive oil and were irradiated with a dose of 15 Gy of gamma radiation; irradiated, in which animals were irradiated with a dose of 15 Gy gamma radiation; vitamin E, which received {alpha}-tocopherol acetate solution; vitamin E/irradiated, which received {alpha}-tocopherol acetate solution before irradiation with a dose of 15 Gy gamma rays. Half of the animals were euthanized at 8 h, and the remaining at 30 days after irradiation. Both parotid glands were surgically removed and morphometric analysis of acinar cells was performed. Data were subjected to two-way ANOVA and Tukey's test ({alpha}=0.05). Morphometric analysis showed a significant reduction in the number of parotid acinar cells at 30 days in olive oil/irradiated and irradiated groups. In groups evaluated over time a significant reduction was shown at 30 days in olive oil/irradiated and irradiated groups, indicating that ionizing radiation caused tissue damage. The vitamin E/irradiated group presented more acinar cells than the irradiated group, but no statistically significant difference was observed (p>0.05). In conclusion, vitamin E seems to have failed as a radioprotective agent on acinar cells in rat parotid glands. (author)

  18. Fifth meeting of persons competent in radiation protection; Cinquiemes rencontres des personnes competentes en radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    During this meeting will successively be approached: the statutory frame, the practical guide for the realization of the dosimetry studies of work stations presenting a risk of exposure to ionizing radiations, a study of post in conventional and interventional radiology, study of post in interventional cardiology, the roles and the missions of the P.C.R. (person competent in radiation protection) in a subcontractor company in I.N.B. (base nuclear installation), the application of the zoning order for the activities of industrial radiography, the evolution of the statutory measures in protection of the workers against the dangers of ionizing radiations, all which concerns the P.C.R. (training, missions, certification, educational role), the controls of radioprotection, the external controls of radioprotection, the surveillance of working zones, surveillance of effluents,management of the radioactive waste and effluents, classification of the personnel and the surveillance of the exposure, dosimetry by radio photo luminescence, the systeme S.I.S.E.R.I.. (N.C.)

  19. Vasoactive and radioprotective properties of isothiourea derivatives having NOS-inhibitory activity

    Energy Technology Data Exchange (ETDEWEB)

    Filimonova, Marina V.; Shevchenko, Ludmila I.; Ulyanenko, Stepan E.; Makarchuk, Victorya M.; Kuznetsova, Mary N.; Shevchuk, Aza S.; Lushnikova, Galina A.; Chesnakova, Ekaterina A. [Medical Radiological Research Center Health Ministry of Russia, 4, Korolev street, Obninsk, 249036, Kaluga region (Russian Federation)

    2014-07-01

    We studied vasoactive and radioprotective properties of new original N-acyl, S-alkyl isothiourea derivatives which are potent inhibitors of nitric oxide synthases (preferably eNOS and iNOS). These compounds have a moderate toxicity (LD50 - 400-550 mg/kg), and are stable in aqueous solutions. In hemodynamic studies, these compounds exhibited high vasotropic activity. The use of these compounds in doses of 5-15 mg/kg (0,01-0,03 LD{sub 50}) in the experimental animals in a state of the severe hemorrhagic or endo-toxic shock causes a potent vasopressor effect, accompanied by a significant and continuous rise in blood pressure. The increasing of vascular tone developed over 2-5 min after injection and persisted for at least 60-90 minutes, excelling at least 3-5 times the duration of α1-adreno-mimetic vasopressor action. The rapid increase in vascular tone under the influence of these compounds in normo-tonic animals caused protective baroreflex to prevent high blood pressure. At doses of 10-15 mg/kg the reflex reaction was mild, but at higher doses (30-40 mg/kg) the reaction was fierce and prolonged, and was accompanied by severe bradycardia, decreasing of the cardiac output and a significant weakening of the peripheral blood flow. In all cases, the hemodynamic response was reflexive and easily eliminated by atropine. The ability of these compounds to induce circulatory hypoxia was the basis for the study of their radioprotective properties. The study of radioprotective effect on the survival of animals exposed to lethal doses of γ-radiation (10 Gy) and on the survival of hematopoietic clonogenic cells showed that these compounds in doses of 80-150 mg/kg (0,2-0,3 LD50) have considerable radioprotective action, which is comparable with the protective effect of the maximum tolerated dose of cystamine. The factor of change in dose for γ-radiation, estimated by the LD{sub 50}, was 1,42-1,58. We also investigated the ability of the test compounds, due to their hypoxic

  20. Vasoactive and radioprotective properties of isothiourea derivatives having NOS-inhibitory activity

    International Nuclear Information System (INIS)

    We studied vasoactive and radioprotective properties of new original N-acyl, S-alkyl isothiourea derivatives which are potent inhibitors of nitric oxide synthases (preferably eNOS and iNOS). These compounds have a moderate toxicity (LD50 - 400-550 mg/kg), and are stable in aqueous solutions. In hemodynamic studies, these compounds exhibited high vasotropic activity. The use of these compounds in doses of 5-15 mg/kg (0,01-0,03 LD50) in the experimental animals in a state of the severe hemorrhagic or endo-toxic shock causes a potent vasopressor effect, accompanied by a significant and continuous rise in blood pressure. The increasing of vascular tone developed over 2-5 min after injection and persisted for at least 60-90 minutes, excelling at least 3-5 times the duration of α1-adreno-mimetic vasopressor action. The rapid increase in vascular tone under the influence of these compounds in normo-tonic animals caused protective baroreflex to prevent high blood pressure. At doses of 10-15 mg/kg the reflex reaction was mild, but at higher doses (30-40 mg/kg) the reaction was fierce and prolonged, and was accompanied by severe bradycardia, decreasing of the cardiac output and a significant weakening of the peripheral blood flow. In all cases, the hemodynamic response was reflexive and easily eliminated by atropine. The ability of these compounds to induce circulatory hypoxia was the basis for the study of their radioprotective properties. The study of radioprotective effect on the survival of animals exposed to lethal doses of γ-radiation (10 Gy) and on the survival of hematopoietic clonogenic cells showed that these compounds in doses of 80-150 mg/kg (0,2-0,3 LD50) have considerable radioprotective action, which is comparable with the protective effect of the maximum tolerated dose of cystamine. The factor of change in dose for γ-radiation, estimated by the LD50, was 1,42-1,58. We also investigated the ability of the test compounds, due to their hypoxic mechanism of

  1. Studies on in vivo radioprotective efficacy of triazole-3-thione derivative against electron beam induced oxidative stress on Drosophila Melanogaster

    International Nuclear Information System (INIS)

    1,2,4-triazole derived molecules have received much attention in the field of medicinal chemistry due to their versatile biological properties including antibacterial, antifungal, anticonvulsant, anti-inflammatory, anticancer, and antiproliferative properties. They are also used as starting materials for the synthesis of biologically active N-bridged heterocycles. Triazole derivatives with sulfhydryl group are known for radioprotective activity. In the present study we have evaluated the radioprotective efficacy of 4-amino-5-(4-chlorobenzyl)-2, 4-dihydro-3H-1, 2, 4-triazole-3-thione against electron beam induced oxidative stress on Drosophila melanogaster. The compound was synthesized by green approach using solvent free fusion of thiocarbohydrazide and p-Chloro phenyl acetic acid and was characterized on the basis of analytical and spectral data . The synthesized molecule showed good DPPH radical scavenging activity. Hence this compound was screened for radioprotective activity. The electron beam irradiated flies were assayed for oxidative stress markers namely, Thiobarbituric acid reactive substances (TBARS), Hydroperoxide (HP), enzymatic antioxidants namely Superoxide dismutase (SOD), Catalase (CAT), Glutathione-S-transferase and Non enzymatic antioxidants such as Glutathione (GSH). The results showed that the molecule has potent radioprotective activity. (author)

  2. Radioprotective effects of ginsan and amifostine (WR-2721) against {gamma}-ray induction of micronuclei in mice bone marrow erythroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Ivanova, Tatiana; Song, Jie Young; Han, Young Soo; Jung, In Sung; Yun, Yeon Sook [KIRAMS, Seoul (Korea, Republic of)

    2004-07-01

    It is common knowledge that the use of combinations of agents is a promising approach for maximizing radioprotection with minimal adverse effects. So it has been known that amifostine has powerful protective action against irradiation. However, its toxicity has limited its application in medicine or in hazardous radiation environments.

  3. Hydrological cycles and trends in the NW Argentine Andes since 1940

    Science.gov (United States)

    Castino, Fabiana; Bookhagen, Bodo; Strecker, Manfred

    2016-04-01

    Strong spatiotemporal variability characterizes the hydrometeorological pattern in the NW Argentine Andes, draining parts of the most populated and economically important areas of South America. During the summer monsoon season (DJF), the eastern flanks of the central Andes are characterized by deep convection, exposing them to extreme hydrometeorological events. These often result in floods and landslides with disastrous effects on the local populations. Here, we analyze river discharge to explore long-term hydrological variability in NW Argentine Andes and the linked climate controlling processes. We rely on 13 daily river discharge time series relevant to drainage basins spanning several size orders (102-104 km2) starting in 1914 and define different hydro-climate indices both for the mean and the extreme hydrological events. We apply quantile regression to investigate long-term trends and spectral analysis associated with cross-correlation with SST-based climate indices to identify links to large-scale climate variability modes. River discharge presents a pronounced and coherent variability signal in South America, particularly for wide drainage basins, such as the Amazon and Paraná/La Plata rivers, strongly associated to Pacific and Atlantic Oceans Sea Surface Temperature (SST) anomalies (i.e. ENSO, PDO, AMO). Our analysis evidences that in the NW Argentine Andes, mean discharge values are characterized by statistically significant, mostly positive, long-term trends since 1940, whereas the extreme events present a more non-unidirectional trend pattern. Also, coherent multi-annual to multi-decadal cycles characterizing the discharge pattern have been identified, suggesting that processes linked to SST anomaly-modes strongly control the hydrometeorology variability in the NW Argentina Andes.

  4. Hantavirus reservoir Oligoryzomys longicaudatus spatial distribution sensitivity to climate change scenarios in Argentine Patagonia

    Directory of Open Access Journals (Sweden)

    González Paula LM

    2009-07-01

    Full Text Available Abstract Background Oligoryzomys longicaudatus (colilargo is the rodent responsible for hantavirus pulmonary syndrome (HPS in Argentine Patagonia. In past decades (1967–1998, trends of precipitation reduction and surface air temperature increase have been observed in western Patagonia. We explore how the potential distribution of the hantavirus reservoir would change under different climate change scenarios based on the observed trends. Methods Four scenarios of potential climate change were constructed using temperature and precipitation changes observed in Argentine Patagonia between 1967 and 1998: Scenario 1 assumed no change in precipitation but a temperature trend as observed; scenario 2 assumed no changes in temperature but a precipitation trend as observed; Scenario 3 included changes in both temperature and precipitation trends as observed; Scenario 4 assumed changes in both temperature and precipitation trends as observed but doubled. We used a validated spatial distribution model of O. longicaudatus as a function of temperature and precipitation. From the model probability of the rodent presence was calculated for each scenario. Results If changes in precipitation follow previous trends, the probability of the colilargo presence would fall in the HPS transmission zone of northern Patagonia. If temperature and precipitation trends remain at current levels for 60 years or double in the future 30 years, the probability of the rodent presence and the associated total area of potential distribution would diminish throughout Patagonia; the areas of potential distribution for colilargos would shift eastwards. These results suggest that future changes in Patagonia climate may lower transmission risk through a reduction in the potential distribution of the rodent reservoir. Conclusion According to our model the rates of temperature and precipitation changes observed between 1967 and 1998 may produce significant changes in the rodent

  5. Musical Preferences of Argentines and Uruguayans Living in Australia: Implications for Music Therapy Clinical Practice

    Directory of Open Access Journals (Sweden)

    Christobel C Moore

    2009-03-01

    Full Text Available This article provides an overview of the elements that impact on the cultural identity of Argentines and Uruguayans in Australia, their relationship to music and the implications for music therapy clinical practice. A survey collected quantitative data on musical preferences and qualitative data on what respondents associated with different genres. The final sample of 12 respondents was not representative of the Australian communities, but collected data was congruent with the reviewed literature and significant internal consistency was observed.Classical music, ballads, folk and tango had the highest preference across age groups with consistent associations on musical, intrapersonal, interpersonal and abstract levels.

  6. Equity during an economic crisis: financing of the Argentine health system.

    Science.gov (United States)

    Cavagnero, Eleonora; Bilger, Marcel

    2010-07-01

    This article analyses the redistributive effect caused by health financing and the distribution of healthcare utilization in Argentina before and during the severe 2001/2002 economic crisis. Both dramatically changed during this period: the redistributive effect became much more positive and utilization shifted from pro-poor to pro-rich. This clearly demonstrates that when utilization is contingent on financing, changes can occur rapidly; and that an integrated approach is required when monitoring equity. From a policy perspective, the Argentine health system appears vulnerable to economic downturns mainly due to high reliance on out-of-pocket payments and the strong link between health insurance and employment.

  7. Graphic correlation of Argentine Precordillera and North American Lower/Middle Ordovician sections

    Institute of Scientific and Technical Information of China (English)

    Walter C.Sweet; Guillermo L.Albanesi

    2006-01-01

    @@ Present work demonstrates that a level equivalent to the proposed Whiterockian basal GSSP can be located graphically in a composite section anchored by the Niquivil section of the Argentine Precordillera. The FAD of Cooperignathus aranda in the Niquivil composite section, a candidate for GSSP of the Lower/Middle Ordovician boundary, projects to a level very close to the FAD of Tripodus laevis in the Whiterockian reference section. The conodont-based framework reported here includes the potential for recognition of the proposed Whiterock Canyon-based GSSP, the Cooperignathus aranda-based GSSP, and, possibly, the Baltoniodus triangularisbased GSSP, recently proposed.

  8. Social and cognitive determinants in entrepreneurial interest: an exploratory study among argentine students

    Directory of Open Access Journals (Sweden)

    ANA MARÍA ROMERO MARTÍNEZ

    2008-06-01

    Full Text Available In this paper we analyze the intentions in creating a business on the part of a group of Argentine students in Strategic Human Resources Management in the University of Buenos Aires. The results of the study show that these students want to create their own business, but their possibilities depend on several factors. Among all of them, self-effi cacy stands out; those students who show more self-effi cacy are those who demonstrate more intention for creating a business. This intention is minor for the students who possess more social support. Neither family charges nor previous experience in entrepreneurship have a signifi cant effect.

  9. Food habits of common barn-owls along an elevational gradient in Andean Argentine Patagonia

    OpenAIRE

    Travaini, Alejandro; Donázar, José A.; Ceballos, Olga; Rodríguez, Alejandro; Hiraldo, F.; Delibes, M.

    1997-01-01

    We evaluated the diet of Common Barn-owls (Tyto alba) along an elevational gradient in Argentine Patagonia. Small mammals (mainly rodents) were the main prey accounting for 93.2% of total prey items. Consumption of rodents appeared to be dependent on their availability. Sizes of mam­ malian prey were variable but most ranged from 10—100 g in body mass. We concluded that the diet of these barn owls could be used as an index of cricetid rodent populations along ...

  10. Radioprotective effects of CBLB502 on γ-radiated Rhesus monkey

    Directory of Open Access Journals (Sweden)

    Xing SHEN

    2015-06-01

    Full Text Available Objective A Rhesus monkey model was employed to study the radioprotective effects of a Toll-like receptor 5 agonist, CBLB502, against 7.0Gy whole-body irradiation of 60Co gamma-rays. Methods Thirty animals were assigned to a placebo treatment group, a WR-2721 positive control group, and three CBLB502 treatment groups (n=6 animals/group. Each animal was irradiated with 7.0Gy 60Co γ and given CBLB502 at 2.5, 10 and 40μg/kg, respectively in treatment groups, or WR-2721 at 30mg/kg, or physiological saline 0.3ml/kg for the placebo treatment group. The treatment was given once by intramuscular injection 30 min before irradiation. All irradiated animals received symptomatic treatment based on same guidelines. General observation, peripheral blood tests, hemopoietic progenitor cell colony-counting, and histopathological examination were performed. Results We found that 10 or 40μg/kg CBLB502 treatment resulted in 100% survival, while the survival rate was 33% in placebo treatment group. Hematopoietic recovery in the WR-2721 treatment group was marginally superior to the irradiation control group. Nadirs of peripheral white cell and platelet counts of animals treated with 40μg/kg of CBLB502 were significantly higher than those of the placebo treatment group (P<0.05. CBLB502 at 40μg/kg also gave a shortened duration of low platelet count, earlier recovery time, reduced the amount of blood transfusion and damage to the bone marrow and intestine. Conclusion All Rhesus monkeys irradiated with 7.0Gy 60Co γ-rays would suffer from severe acute radiation sickness of hematopoietic system. CBLB502 at 40μg/kg is radioprotective in this model and a single intramuscular injection of CBLB502 in a dose of 40μg/kg 30min before irradiation gives better radioprotective effects than WR-2721. DOI: 10.11855/j.issn.0577-7402.2015.04.07

  11. ''Drageny I'' has radioprotective effects in radiation-injured rat model induced by heavy ions

    International Nuclear Information System (INIS)

    In order to elucidate biological effects and mechanisms of heavy ion radiation in rats and protective effects of anti-radioactive agents ''drageny I'', animal model exposed to heavy ion radiation was established. Rats of model group and ''drageny I'' group were irradiated by heavy ions with 7 Gy in head (other parts of rats were not radiated). Then, all rats will be dealt with at different time points (24 h, 3 d and 7 d after radiation). General conditions, body weights, organs index were observed. The results showed that compared with model group, drug group's general conditions and body weights were better to a certain extent. Two rats of model group were dead and no rats of drug group after radiation. Tested drug could also regulate the immune organs index with statistical significance as compared with model group (P<0.05-0.01). The results obtained here showed that ''drageny I'' had radioprotective effects obviously. (author)

  12. Radioprotective effects of active compounds from Acanthopanax senticosus of Lesser Khingan Mountain in China

    Science.gov (United States)

    Lu, Weihong; Sun, Yeqing; Shi, Jinming

    Bioactive compounds including polysaccharides, flavones, syringin and eleutheroside E were extracted from wild Acanthopanax senticosus and purified by chromatography. In vitro and in vivo anti-radiation activities of the compounds were compared. In vitro radical scavenging results showed that polysaccharides and flavones were more effective than syringin and eleutheroside E in In vivo study proved that polysaccharides and flavones were effective in protecting mice from heavy ion radiation induced oxidative damages. Also, the activity of polysaccharides and flavones in repressing expression changes of radiation response proteins including heat shock protein, disulfide-isomerase and glutathione S-transferase were also found by our results. Moreover, the radioprotective effects were more significant when polysaccharides and flavones were used together.

  13. Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) Extract in Swiss albino mice

    International Nuclear Information System (INIS)

    The radioprotective efficacy of aqueous extract of Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. The oral administration of Rajgira extract at 800 mg/kg body weight/day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 6.33 and 8.62 Gy for irradiation alone and Rajgira+irradiation group, respectively, giving a dose reduction factor of 1.36. This effect of Rajgira accompanied the increased endogenous spleen colonies and the spleen weight without any side effect or toxicity, as well as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid peroxidation assessed in the liver and the blood. (author)

  14. American Society of Echocardiography

    Science.gov (United States)

    American Society of Echocardiography Join Ase Member Portal Log In Membership Member Portal Log In Join ASE Renew Benefits Rates FASE – Fellow of the American Society of Echocardiography Member Referral Program FAQs Initiatives Advocacy ...

  15. Society of Interventional Radiology

    Science.gov (United States)

    ... how interventional radiology research improves patients’ lives at Society of Interventional Radiology’s 2017 Annual Scientific Meeting; read ... comments to CMS on two MACRA coding issues; society is engaged with CMS as they develop codes ...

  16. International Transplant Nurses Society

    Science.gov (United States)

    ... 25th Annual ITNS Symposium The International Transplant Nurses Society (ITNS) cordially invites transplant nurses and other transplant ... pocket guide, developed by the International Transplant Nurses Society (ITNS), provides an overview of the interventions used ...

  17. Ehlers-Danlos Society

    Science.gov (United States)

    ... Scientific Board Staff Volunteer Leaders The Ehlers-Danlos Society Center for EDS Research & Clinical Care Our History ... Message Boards Patient Resource Library The Ehlers-Danlos Society Center for EDS Research & Clinical Care Loose Connections ...

  18. Scoliosis Research Society

    Science.gov (United States)

    Back To Top Scoliosis Research Society Close Menu Member Login Become a Member Home Find a Specialist | Calendar Contact | Donate Patients and Families ... a Member Find a Specialist Calendar Contact Donate Scoliosis Research Society Dedicated to the optimal care of ...

  19. Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa

    Directory of Open Access Journals (Sweden)

    L.A Lozina

    2010-12-01

    Full Text Available The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double-blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a topical placebo in the treatment of otitis externa. The propolis preparation and placebo were administrated into both external ear canals, twice daily for 14 days. Throughout the study, clinical examination and microbiological analysis of dogs ear exudates were made. The most frequent microorganisms isolated in culture media were: Malassezia pachydermatis (54.2%, Staphylococcus aureus (43.8%, coagulase-negative Staphylococcus (25.0%, Pseudomonas aeruginosa (20.8%, Candida albicans (18.8%, Proteus mirabilis (16.7%, Streptococcus spp. (16.7%, Enteroccocus faecalis (12.5%, Escherichia coli (12.5%, Staphylococcus intermedius (6.3%, Klebsiella spp. (4.2%, andCandida glabrata (2.1%. Whereas the control group did not recover from the infectious ear disease, the propolis preparation exhibited antimicrobial activity against most of the microorganisms isolated from samples of the treated group. In addition, no propolis-adverse effects were observed. This allowed propolis-treated patients to show a significant improvement of the clinical parameters. Thus, this new Argentine propolis ear drop formulation may be used for topical treatment of otitis externa in dogs.

  20. Portrayals of character smoking and drinking in Argentine-, Mexican- and US-produced films.

    Science.gov (United States)

    Kollath-Cattano, Christy; Abad-Vivero, Erika N; Mejia, Raul; Perez-Hernandez, Rosaura; Sargent, James D; Thrasher, James F

    2016-09-01

    The aim of this study was to assess film character portrayals of tobacco and alcohol use in US and nationally-produced films that were popular in Argentina and Mexico from 2004-2012. We performed a content analysis of these films (n=82 Argentine, 91 Mexican, and 908 US films, respectively). Chi-squares and t-tests were used to compare characteristics of characters who smoked or drank by country of movie production. Then data from all countries were pooled, and generalized estimating equation (GEE) models were used to determine independent correlates of character smoking or drinking. There were 480 major characters for Argentine-, 364 for Mexican-, and 4962 for US-produced films. Smoking prevalence among movie characters was similar to population smoking prevalence in Mexico (21%) and Argentina (26%), but about half in the US (11%), where movie product placements are restricted. Movie smoking declined over the period in all three countries. Movie alcohol prevalence was 40-50% across all countries and did not change with time. Demographic predictors of character smoking included: being male, 18 and older, having negative character valence. Movie smoking was not associated with lower SES. Predictors of character drinking included: being age 18 and older and positive character valence. Smoking and drinking predicted each other, illicit drug use, and higher scores for other risk behaviors. This suggests that policy development in Mexico and Argentina may be necessary to reduce the amount of character tobacco and alcohol use in films. PMID:27404576

  1. Prosecuting International Crimes at National Level: Lessons from the Argentine ‘Truth-Finding Trials’

    Directory of Open Access Journals (Sweden)

    Elena Maculan

    2012-01-01

    Full Text Available Truth-finding trials (juicios por la verdad constitute a novel solution devised by the Argentine judicial system to cope with crimes committed by the past military dictatorship. This mechanism uses criminal courts as well as criminal procedure in order to investigate the truth about the dictatorship's crimes; however, the trials allow judges neither to establish criminal responsibility nor to punish the perpetrators of crimes. This limitation is due to the inability, imposed by the Full Stop and Due Obedience Laws, to prosecute the perpetrators of crimes.From the perspective of criminal law, truth-finding trials present two problematic features: firstly, their creation and regulation are set by judges, which has caused the development of many non-homogeneous local solutions and, secondly, their hybrid nature, which entails a possible subversion of conventional forms and goals in the context of the criminal trial.The paper also describes the current situation, since the Argentine impunity laws were declared unconstitutional and criminal proceedings reopened. The new framework provokes questions about the relationship between the reopened criminal trials and the truth-finding investigations, not only with regard to evidentiary issues but also with respect to the reason why the truth-finding investigations are still held.Finally, the shift from a non-punitive approach to the current full criminal accountability seems to suggest that truth-finding trials were merely a temporary solution, while the notion of the full prosecution and punishment of State crimes was never really set aside.

  2. Mutual Organizations, Mutual Societies

    OpenAIRE

    Archambault, Edith

    2009-01-01

    This article is an entry to be published in an International Encyclopedia of Civil Society in 2009. Mutual organizations exist everywhere in developed and developing countreies as well. After a definition founded on social economy principles, the paper gives the historical background of mutual insurance companies, mutual benefit societies and building societies. Then we draw a panorama of the European mutual societies with international perspectives on the USA and some developing countries. S...

  3. Reclaiming Society Publishing

    Directory of Open Access Journals (Sweden)

    Philip E. Steinberg

    2015-07-01

    Full Text Available Learned societies have become aligned with commercial publishers, who have increasingly taken over the latter’s function as independent providers of scholarly information. Using the example of geographical societies, the advantages and disadvantages of this trend are examined. It is argued that in an era of digital publication, learned societies can offer leadership with a new model of open access that can guarantee high quality scholarly material whose publication costs are supported by society membership dues.

  4. Radioprotective Properties of Allium sativum (Garlic Extract on Cultured Human Lymphocytes against Electron Beam Radiation

    Directory of Open Access Journals (Sweden)

    Shama N Rao

    2015-03-01

    Full Text Available The radioprotective effects of naturally occurring compounds from herbs have been investigated in vitro and in vivo considering their ethnopharmacological role in prevention and treatment of cancer. Allium sativum supplementation in diet has been shown to be beneficial to cancer patients. The present study was designed to detect the radioprotective effect of garlic extract (GE on cultured human peripheral blood lymphocytes. Garlic bulbs were extracted using ethanol and water separately followed by assays on antioxidant activities to assess the efficiency of radical scavenging capacity of various extracts. Lymphocytes were treated with different concentrations of GE for 2, 4, 6 and 24 hr periods. Cell survival was determined by tryphan blue dye exclusion assay, single strand DNA damage by alkaline comet assay and in vitro cytogenetic damages were evaluated by micronucleus assays. Ethanol boiled GE showed highest radical scavenging capacity and reducing property. Treatment of GE to lymphocytes before and after exposure to 4Gy of electron beam radiation (EBR the percentage of tail DNA was reduced from 24.06±3.92 to 2.87±0.18. The elevated micronucleus formation in radiation control group (13.15±0.75 was significantly reduced in various concentrations of GE treated groups (10.35±0.44, 7.05±1.17, 6.42±0.47 respectively. Cells treated with GE at 10µg/mL showed maximum viability after exposure to EBR. Present investigations indicate that ethanol boiled GE shows good radiation protection at 10µg/mL concentration. However, increase in concentration above this dose though resulted in higher protection, increased cell toxicity was also noticed.

  5. Enzymeaticial analysis and soluble proteins assays on radioprotective effects of cordyceps militaris

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Beong Gyu [Wonkwang Health Science College, Iksan (Korea, Republic of); Park, Joon Chul [Ansan 1 College, Ansan (Korea, Republic of)

    2001-06-01

    Effect of single pre-administration of Cordyceps militaries (Cm) extract on the survival ratio, body weight and organ weight changes and blood cell counts after whole-body {gamma}-irradiation were investigated. The single pre-administration of Cm extract at 24 hrs before {gamma}-irradiation increased the 40-day survival ration of irradiated mice from 60.1% to 71/4%. The administration of Cm extract completely prevented weight reductions of spleen and thymus produced by {gamma}-irradiation (P<0.01, P<0.05). Similar but somewhat less radioprotective effect was also found in the testis of the Cm treated mice. The administration of Cm extract retarded the reduction of both leukocyte and lymphocyte counts occured during the first 7 days and accelerated the recovery of the counts thereafter. The extract also accelerated the recovery of the erythrocyte counts occurred after the day 21th. SDS-polyacrylamide gel electrophoresis of the soluble proteins extracted from various organs did not reveal differences to any extent in all groups except in the levers of the irradiated and extract treated groups, in which some proteins were missing or less present. Also, the result of general intra and extra mycelial enzyme assays with Cm, extramycelial enzyme activity was relatively higher than the intramycelial enzyme. Cm appeared to indicate that {alpha}-amylase was the highest among the enzymes and gluosidase and chitinase were followed. Since the spleen, thymus and testis have been well known as radiosensitive organs, the protective action of Cm extract on irradiated mice may be responsible for its enhancing recovery of these organs. Although the exact mechanism in protective effect of Cm extract on irradiated mice is not clear yet, the present study is the first report regarding the Cm which was tested and found to be a potential radioprotective agent.

  6. Art state of radioprotection laboratory of Centro Regional de Referencia para la Dosimetria: CNEA, CAE

    International Nuclear Information System (INIS)

    External radiation quantity can be measured in terms of, for example exposure, air kerma, ambient dose equivalent and personal dose equivalent by using radiation measuring instruments. Radiation survey instruments and dosimeters are usually used to determine the amount of radiation from exposure to ionizing radiation and they need to be calibrated to ensure that they give accurate reading with a certain uncertainties. Dosimetry Calibration Laboratories have to be able to fulfil the requirements for traceable and reliable calibrations. A way to demonstrate it is through comparisons with primary or accredited laboratories and the establishment of a quality system following the International Organization for Standardization (ISO) Guide 17025. The Secondary Standard Dosimetry Laboratory (SSDL) of the Argentina 'Centro Regional de Referencia para la Dosimetria (CRRD)', C.N.E.A, is the national centre for the calibration of measuring instruments used in radiation protection and radiotherapy. The main facilities related to radioprotection include a constant potential X-ray system with a 300 kV tube and a new Hopewell Designs, Inc. Irradiator gamma Model G10-2-2600 (lead attenuator of 2, 4 and 6cm). Reference standard dosimeters traceable to the BIPM Dosimetry Laboratory and the IAEA (International Atomic Energy Agency) Dosimetry Laboratory are used in the calibration procedures by comparison with points calibrated. In this work a compilation of data obtained from instruments calibration and dosimeters irradiation that were carried on in CRRD during the last years is presented. Reported data are: amount of instruments calibrated per month, per kind, manufacturer and model. At the end of the year is planning to do the first internal audit to could accredit the Radioprotection procedures next year. (author)

  7. Radioprotection on a large construction site located in the Chernobyl exclusion zone

    International Nuclear Information System (INIS)

    Since the tragic accident of the reactor n, units 1, 2 and 3 of the Chernobyl Nuclear Power Plant (ChNPP) have been successively stopped. However, since the independence of the Ukraine in 1991, Russia becomes no longer responsible for reprocessing Ukrainian spent fuel. With the support of the International Community, Ukraine agreed to an interim storage solution. In July 1999, following an international invitation to tender, Ukrainian Ministry, EnergoAtom, chooses a consortium of three French companies, Framatome, Vinci Construction and Bouygues Travaux Public, to build an storage facility. Construction of the 'Interim Storage Facility-2' (ISF-2) for long term storage of the spent fuel from Chernobyl Units 1, 2 and 3, starts in March 2000. The specific feature of this civil engineering project is its location in the vicinity of the power plant, within the 'exclusion zone'. The setting up of such a major construction site in a contaminated environment requires a particular attention in radiological safety field. After a brief description the project, of its environment and radiological safety provisions, this report details the safety measures put in place and the peculiarities of the site. Different safety cultures and occasional misunderstandings between Ukrainian and Western staff created additional difficulties. In the radioprotection field, the French companies committed significant means and undertook prevention training activities in order to develop awareness of radiological risks by both expatriate and Ukrainian personnel. The experience gained on this site may be described as beneficial in the sense that it teaches lessons for use on future sites in similar conditions.staff created additional difficulties. In the radioprotection field, the French companies committed significant means and undertook prevention training activities in order to develop awareness of radiological risks by both expatriate and Ukrainian personnel. The experience gained on this site

  8. Prospects in the development of natural radioprotective therapeutics with anti-cancer properties from the plants of Uttarakhand region of India

    OpenAIRE

    Painuli, Sakshi; Navin KUMAR

    2016-01-01

    Radioprotective agents are substances those reduce the effects of radiation in healthy tissues while maintaining the sensitivity to radiation damage in tumor cells. Due to increased awareness about radioactive substances and their fatal effects on human health, radioprotective agents are now the topic of vivid research. Scavenging of free radicals is the most common mechanism in oncogenesis that plays an important role in protecting tissues from lethal effect of radiation exposure therefore r...

  9. Analysis of genetic diversity and population structure in Argentine and Bolivian Creole cattle using five loci related to milk production

    Directory of Open Access Journals (Sweden)

    Lirón J.P.

    2002-01-01

    Full Text Available Data from five protein-coding loci related to dairy production were used to study the genetic diversity and population structure of Argentine and Bolivian Creole cattle breeds. Genomic DNA was extracted from blood samples of six Creole cattle breeds: Argentine (n = 230, Patagonian (n = 25; "Saavedreño" (n = 140, "Chaqueño Boliviano" (n = 30, "Yacumeño" (n = 27, and "Chusco" (n = 11. kappa-casein, beta-lactoglobulin, growth hormone and prolactin were measured by PCR-RFLP, while alphaS1-casein was typed by PCR-ASO. The results are discussed, focusing on: historical origin, recent differentiation and selection events, Zebu gene introgression, and population structure. This work shows that: (i For the studied genes, the observed gene frequency profiles of Argentine and Bolivian Creole cattle breeds were close to the data reported for Iberian breeds and for other South-American Creole cattle breeds which are historically related; (ii although Zebu gene introgression has been reported at the studied loci, these breeds seem to be far from the Zebu gene frequency profiles; and (iii the Argentine and Bolivian Creole cattle showed significant levels of subdivision, but each population has maintained its degree of genetic variability.

  10. Indian Vacuum Society: The Indian Vacuum Society

    Science.gov (United States)

    Saha, T. K.

    2008-03-01

    The Indian Vacuum Society (IVS) was established in 1970. It has over 800 members including many from Industry and R & D Institutions spread throughout India. The society has an active chapter at Kolkata. The society was formed with the main aim to promote, encourage and develop the growth of Vacuum Science, Techniques and Applications in India. In order to achieve this aim it has conducted a number of short term courses at graduate and technician levels on vacuum science and technology on topics ranging from low vacuum to ultrahigh vacuum So far it has conducted 39 such courses at different parts of the country and imparted training to more than 1200 persons in the field. Some of these courses were in-plant training courses conducted on the premises of the establishment and designed to take care of the special needs of the establishment. IVS also regularly conducts national and international seminars and symposia on vacuum science and technology with special emphasis on some theme related to applications of vacuum. A large number of delegates from all over India take part in the deliberations of such seminars and symposia and present their work. IVS also arranges technical visits to different industries and research institutes. The society also helped in the UNESCO sponsored post-graduate level courses in vacuum science, technology and applications conducted by Mumbai University. The society has also designed a certificate and diploma course for graduate level students studying vacuum science and technology and has submitted a syllabus to the academic council of the University of Mumbai for their approval, we hope that some colleges affiliated to the university will start this course from the coming academic year. IVS extended its support in standardizing many of the vacuum instruments and played a vital role in helping to set up a Regional Testing Centre along with BARC. As part of the development of vacuum education, the society arranges the participation of

  11. Evaluation of radioprotective effect of aloe vera and zinc/copper compounds against salivary dysfunction in irradiated rats.

    Science.gov (United States)

    Nejaim, Yuri; I V Silva, Amaro; V Vasconcelos, Taruska; J N L Silva, Emmanuel; M de Almeida, Solange

    2014-09-01

    The aim of this study was to evaluate the radioprotective and reparative effects of compounds based on aloe vera, zinc, and copper against salivary gland dysfunction in Wistar rats. A total of 150 Wistar rats were randomly divided into 12 groups, in which the animals received aloe vera and/or zinc and copper. In eight of these groups the animals were also subjected to irradiation before or after administration of the substances. After 27 days, sialometry tests were performed. Data were analyzed using ANOVA and the Tukey test (P aloe vera before or after irradiation showed a significantly higher salivary flow rate than rats that had been simply irradiated. When both substances were administered, a statistically significant difference in the salivary flow rate was observed in comparison with the irradiation alone group seven days after irradiation. The present results suggest that aloe vera exerts positive protective and reparative effects, and can be considered a potential radioprotective substance.

  12. Radioprotection in the infirmary praxis in service of hemodynamic; Radioprotecao na praxis da enfermagem em servico de hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Flor, Rita de Cassia, E-mail: flor@ifsc.edu.br; Gelbcke, Francine Lima, E-mail: fgelbcke@ccs.ufsc.b [Universidade Federal de Santa Catarinha (CCS/UFSC), Florianopolis, SC (Brazil). Secretaria do Programa de Pos-Graduacao em Enfermagem

    2011-10-26

    Qualitative study made in a hemodynamic service at Santa Catarina, Brazil, viewing to analyse the attitude of workers in infirmary related to the use of radioprotection measurements in interventionist procedures. A methodology of Labor Psycho dynamics was used through the observations, collective interviews and the document analysis. Totally it was realized 36 encounters, completed a total of 54 observation hours. The results have shown that the workers used defense strategies for justification the not use of some radioprotection measurements. Yet, become evident that the measurements related to the distance from the radiation source and the exposure time have not used sometimes, perhaps due to negligence. Finally, it was concluded that, some attitudes adopted by the workers referred to the lack of a continued educational program

  13. The agreement between the Argentine Republic and Australia on the cooperation for the peaceful uses of nuclear energy and its fitting to the Argentine Constitution

    International Nuclear Information System (INIS)

    To analyze the legal aspects of the cooperation agreement between Australia and Argentina signed in Camberra on August 8, 2001, the authors elaborate upon the following points: 1. The interpretation of the constitutional texts. Its need; 2. Facts: the development of nuclear energy in Argentina. The contract INVAP-ANSTO. The cooperation agreement Argentina-Australia; 3. The great publicity campaign. The appeal to fear; 4. The difference with the case of power reactors. Distinction between power and research reactors; 5. The difference with the Chernobyl case; 6. Shipment safety; 7. Other clarifications; 8. Factual and juridical distinction between spent fuel and radioactive waste concepts; 9. The regulatory framework of the difference; 10. The essence of the adjective 'Immediate'. Its juridical meaning; 11. The concept of 'entry'. The need to overcome an intentional literalness; 12. The harmonious interpretation of the constitution; 13. The engagement with the future generations; 14. The adaptation to the global trends. The Kyoto protocol; 15. The bases of the constitutional doctrine. They conclude that nothing in the agreement is contrary to the Argentine constitution

  14. I.R.D. annual report - 1988. Institute of Radioprotection and Dosimetry of Brazilian Nuclear Energy Commission (CNEN)

    International Nuclear Information System (INIS)

    This is the annual report of the activities developed by the Institute of Radioprotection and Dosimetry -IRD/CNEN-Brazil, in the year of 1988. It is composed by the individual reports of its several divisions, describing the main activities and personnel: DEPRO - Occupational and Radiological Protection Dept.; DEPRA - Environmental and Radiological Protection Dept.; DEMET - Metrology Dept.; DEPAT - Technical Support Dept.; DETAC - Scientific Support and Training Dept.; DEPAD -Administrative Support Dept. (J.A.M.M.)

  15. Medical program in radiation protection from the Argentine Nuclear Regulatory Authority

    International Nuclear Information System (INIS)

    This program is carried out by the Radio pathology Laboratory, belonging to the Nuclear Regulatory Authority. The program includes the following aspects: 1) planning and organization of medical response in radiological emergencies. A three-level system of medical assistance has been developed considering: a- determination of each level of care and their potential roles; b- choice of medical facilities for medical assistance; c- preparedness for medical response (equipment s, logistic support, human resources, training). 2) scientific research activities related to radio pathology subjects: a- hematological indicators in radioinduced aplasia; b- biological and biophysical dosimeters; c- radiation effects on the developing brain. 3) edition of practical guidelines for diagnostic and treatment: a- external and internal radioactive contamination; b- acute radiation syndrome; c- radiological burns. 4) medical advising in radioprotection (risk assessment in radiation workers, medical exposures, potential effects of prenatal irradiation). 5) international interactions: activities related with the constitution of a Latin American radio pathology network, linkage with international reference centers. (author)

  16. Radioprotective effect of the extract of Ziziphus joazeiro and Anacardium occidentale on embryos of Biomphalaria glabrata submitted to ionizing radiation

    International Nuclear Information System (INIS)

    Electromagnetic radiations are energies that can be classified as non-ionizing and ionizing. This type of energy is propagated by a material medium and the vacuum. The important characteristic of ionizing radiation is the localized release of large amounts of energy. The biological effects of radiation result principally from damage to DNA, which is the critical target. Given these harmful effects caused by radiation highlights the importance of acquiring knowledge about the radioprotective substance, because they act to protect the living tissue, decreasing the damage he caused by the effects of radiation. In this study we investigated the radioprotective effect of extract hydroalcoholic of Ziziphus joazeiro and Anacardium occidentale on embryos of Biomphalaria glabrata. The embryos of Biomphalaria glabrata pigmented were divided into 18 groups of 100 specimens. The experimental groups were exposed to the extracts at a concentration of 200 ppm and then irradiated. For irradiation, we used a source of 60Co (Gammacell of Radionics Labs. Dose rate = 4.359 Gy/h). The viability of the embryos was examined using a stereoscopic microscope and statistical analysis was performed using the test Student-Newman-Keuls and χ2. Our results showed that the extracts of hydroalcoholic Ziziphus joazeiro showed radioprotective effect and that the aqueous extract of the bark of Anacardium occidentale exhibited a reduction in its embryotoxic effect. (author)

  17. Radioprotective effect of the extract of Ziziphus joazeiro and Anacardium occidentale on embryos of Biomphalaria glabrata submitted to ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Williams N.; Silva, Luanna R.S.; Silva, Edvane B. [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear. Grupo de Estudos em Radioprotecao e Radioecologia; Silva, Ronaldo C. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Genetica; Lacerda, Laila B.N.; Silva, Hianna A.M.F.; Santos, Mariana L.O.; Sa, Jose L.F.; Melo, Ana M.M.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de de Biofisica e Radiobiologia. Lab. de Radiobiologia

    2011-07-01

    Electromagnetic radiations are energies that can be classified as non-ionizing and ionizing. This type of energy is propagated by a material medium and the vacuum. The important characteristic of ionizing radiation is the localized release of large amounts of energy. The biological effects of radiation result principally from damage to DNA, which is the critical target. Given these harmful effects caused by radiation highlights the importance of acquiring knowledge about the radioprotective substance, because they act to protect the living tissue, decreasing the damage he caused by the effects of radiation. In this study we investigated the radioprotective effect of extract hydroalcoholic of Ziziphus joazeiro and Anacardium occidentale on embryos of Biomphalaria glabrata. The embryos of Biomphalaria glabrata pigmented were divided into 18 groups of 100 specimens. The experimental groups were exposed to the extracts at a concentration of 200 ppm and then irradiated. For irradiation, we used a source of {sup 60}Co (Gammacell of Radionics Labs. Dose rate = 4.359 Gy/h). The viability of the embryos was examined using a stereoscopic microscope and statistical analysis was performed using the test Student-Newman-Keuls and {chi}{sup 2}. Our results showed that the extracts of hydroalcoholic Ziziphus joazeiro showed radioprotective effect and that the aqueous extract of the bark of Anacardium occidentale exhibited a reduction in its embryotoxic effect. (author)

  18. Radioprotection in dentistry: Analysis of the Dentistry Faculties of the Rio de Janeiro State not referring at personnel and installations

    International Nuclear Information System (INIS)

    The objective was to show the necessity and the importance of the training and formation of the dentist in radioprotection according to the recent proposal for technical regulations 'Radiological protection directrixes in Medical and Dentistry radiodiagnostic' of the Secretaria do Vigilancia Sanitaria of Ministerio da Saude (SVSMS). This regulation establishes basic standards to radioprotection in the medical and dentistry areas, including principles, limits, obligations and basic controls for the man and environment protection, versus possible improper effects caused by the use of ionizing radiation sources. An analysis of the discipline programs of the Dentistry Schools of Rio de Janeiro state indicates that they show a little or none preoccupation by the radiological protection, which was confirmed through a survey applied toward responsible professors by department or radiology service to the dentistry Schools. This work suggests the creation or adaptation of the existing disciplines introducing radioprotection and images quality in radiodiagnostic, to improve, complement and to make uniform the formation of future dentists optimizing the solution of the identified problems. (Author)

  19. Diet and genotype effects on the quality index of beef produced in the Argentine Pampeana region.

    Science.gov (United States)

    Latimori, N J; Kloster, A M; García, P T; Carduza, F J; Grigioni, G; Pensel, N A

    2008-07-01

    Steers of varying genotypes (Aberdeen Angus, Charolais x AA and Argentine Holstein) in four feeding systems were evaluated. Feeding systems were: S1=a diet based on pastures only; S2=a similar forage base as S1 plus a daily supplementation with cracked corn, at 0.7% of l.w./head/day; S3=a similar forage base as S1 plus a daily supplementation with cracked corn, at 1.0% of l.w./head/day; and S4=a regular feedlot diet. Tenderness and marbling were not affected by the feeding system. Feedlot meat showed an n-6/n-3 ratio significantly higher than meat produced with the diets based on pastures (S1=2.1; S2=3.1; S3=4.5; S4=14.2) (Pmeat with better nutritional characteristics than other productive alternatives, without significant effects of the biotypes. PMID:22062907

  20. Organochlorinated pesticides in the Argentine Antarctic sector and Atlantic coastline waters.

    Science.gov (United States)

    García Fernández, J C; Casabella, A N; Marzi, A A; Astolfi, E; Roses, O; Donnewald, H; Villamil, E

    1979-01-01

    The presence of organochlorinated pesticides in water samples drawn in the Argentine Antarctic Sector and Atlantic coastline has been proved. In general, these samples showed quantities that varied between a few hundredths of a ppmm to slightly more than 1 ppmm, although in some cases and for certain pesticides, depending on the locations, the levels found were definitely higher. With the exception of Dieldrin, which appeared in only one sample/in what would seem to be its course few hundredths of a ppm, to slightly more than 1 ppmm, although in some cases and for certain pesticides found were the same as those reported in previous investigations. The isolated cases of high pesticide contents in water samples drawn at wharves and of snow in the vicinity of Almirante Brown Base show up clearly the influence of human activity on the contamination of the environment.

  1. Basis for the implementation of digital signature in Argentine's health environment

    International Nuclear Information System (INIS)

    The growth of telemedical applications and electronic transactions in health environments is paced by the constant technology evolution. This implies a big cultural change in traditional medicine and in hospital information systems' users which arrival is delayed, basically, by the lack of solid laws and a well defined role-based infrastructure. The use of digital signature as a mean of identification, authentication, confidentiality and non-repudiation is the most suitable tool for assuring the electronic transactions and patient's data protection. The implementation of a Public Key Infrastructure (PKI) in health environment allows for authentication, encryption and use of digital signature for assuring confidentiality and control of the movement of sensitive information. This work defines the minimum technological, legal and procedural basis for a successful PKI implementation and establishes the roles for the different actors in the chain of confidence in the public health environment of Argentine

  2. Dynamics and genetic structure of Argentine ant supercolonies in their native range

    DEFF Research Database (Denmark)

    Vogel, Valérie; Pedersen, Jes S; d'Ettorre, Patrizia;

    2009-01-01

    analyses revealed the presence of 11 supercolonies (width 1 to 515 m) over a 3-km transect. As in the introduced range, there was always strong aggression between but never within supercolonies. The genetic data were in perfect agreement with the behavioral tests, all nests being assigned to identical...... units. Genetic and chemical distances between supercolonies were positively correlated, but there were no other significant associations between geographic, genetic, chemical, and behavioral distances. A comparison of supercolonies sampled in 1999 and 2005 revealed a very high turnover, with about one......Some introduced ant populations have an extraordinary social organization, called unicoloniality, whereby individuals mix freely within large supercolonies. We investigated whether this mode of social organization also exists in native populations of the Argentine ant Linepithema humile. Behavioral...

  3. RECENT TRANSFORMATIONS IN THE ARGENTINE OIL INDUSTRY: THE YPF CASE, 1989-2012

    Directory of Open Access Journals (Sweden)

    Esteban Serrani

    2013-06-01

    Full Text Available The objective of the paper is to analyze the path of the state oil company YPF, from privatization to its expropriation (1989-2012. In this process, it has a special emphasis on the identification and analysis of national peculiarities that explain why in the ‘90s YPF, one of the nation’s premier companies in history, was fully privatized (counter to the regional experience in Mexico, Venezuela and Brazil; and how, just twenty years later, the same company was again in state control, with an expropriation which was widely popular and parliamentary support. It also reviews the main consequences of deregulation and the opening in the Argentine oil sector, especially in the performance of --- since acquired all shares of YPF in 1999, to explain this path.

  4. Copi et Puig, ovnis du théâtre argentin ?

    OpenAIRE

    Souquet, Lionel

    2015-01-01

    C’est en 1968 que Copi (Raúl Damonte Botana, 1939-1987) publie sa première pièce, La journée d’une rêveuse puis, un an plus tard, la très iconoclaste Eva Peron. Par son milieu familial, Copi a baigné dès l’enfance dans la vie théâtrale internationale et a été fortement influencé par sa grand-mère, la dramaturge anarcho-féministe Salvadora Medina Onrubia de Botana. Mais, vivant en exil avec sa famille, Copi est coupé de la réalité de la scène argentine et il écrit d’ailleurs ses premières pièc...

  5. Loss of Wolbachia infection during colonisation in the invasive Argentine ant Linepithema humile

    DEFF Research Database (Denmark)

    Reuter, M.; Pedersen, Jes Søe; Keller, L.

    2005-01-01

    the phylogenies of Wolbachia and its arthropod hosts indicate that infection is frequently lost, but the causes of symbiont extinction have so far remained elusive. Here, we report data showing that colonisation of new habitats is a possible mechanism leading to the loss of infection. The presence and prevalence...... of Wolbachia were studied in three native and eight introduced populations of the Argentine ant Linepithema humile. The screening shows that the symbiont is common in the three native L. humile populations analysed. In contrast, Wolbachia was detected in only one of the introduced populations. The loss...... of infection associated with colonisation of new habitats may result from drift (founder effect) or altered selection pressures in the new habitat. Furthermore, a molecular phylogeny based on sequences of the Wolbachia wsp gene indicates that L. humile has been infected by a single strain. Horizontal...

  6. Medical Management of Acute Radiation Syndromes : Comparison of Antiradiation Vaccine and Antioxidants radioprotection potency.

    Science.gov (United States)

    Maliev, Slava; Popov, Dmitri; Lisenkov, Nikolai

    Introduction: This experimental study of biological effects of the Antiradiation Vaccine and Antioxidants which were used for prophylaxis and treatment of the Acute Radiation Syndromes caused by high doses of the low-LET radiation. An important role of Reactive Oxyden Species (Singlet oxygen, hydroxyl radicals, superoxide anions and bio-radicals)in development of the Acute Radiation Syndromes could be defined as a "central dogma" of radiobiology. Oxida-tion and damages of lipids, proteins, DNA, and RNA are playing active role in development of postradiation apoptosis. However, the therapeutic role of antioxidants in modification of a postradiation injury caused by high doses of radiation remains controversial.Previous stud-ies had revealed that antioxidants did not increase a survival rate of mammals with severe forms of the Acute Radiation Syndromes caused by High Doses of the low-LET radiation. The Antiradiation Vaccine(ARV) contains toxoid forms of the Radiation Toxins(RT) from the Specific Radiation Determinants Group (SRD). The RT SRD has toxic and antigenic prop-erties at the same time and stimulates a specific antibody elaboration and humoral response form activated acquired immune system. The blocking antiradiation antibodies induce an im-munologically specific effect and have inhibiting effects on radiation induced neuro-toxicity, vascular-toxicity, gastrointestinal toxcity, hematopoietic toxicity, and radiation induced cytol-ysis of selected groups of cells that are sensitive to radiation. Methods and materials: Scheme of experiments: 1. Irradiated animals with development of Cerebrovascular ARS (Cv-ARS), Cardiovascular ARS (Cr-ARS) Gastrointestinal ARS(GI-ARS), Hematopoietic ARS (H-ARS) -control -were treated with placebo administration. 2. Irradiated animals were treated with antioxidants prophylaxisis and treatment of Cv-ARS, Cr-SRS, GI-ARS, Hp-ARS forms of the ARS. 3. irradiated animals were treated with radioprotection by Antiradiation Vaccine

  7. Society for Ambulatory Anesthesia

    Science.gov (United States)

    ... Webinars Publications & Resources Clinical Practice Guidelines SAMBA Link Digital ... We Represent Ambulatory and Office-Based Anesthesia The Society for Ambulatory Anesthesia provides educational opportunities, encourages research ...

  8. Proceedings of the eighth scientific meeting; second latin american meeting; first engineering and argentine nuclear industry exposition at Buenos Aires, 5-10 november 1979

    International Nuclear Information System (INIS)

    Compilation of 59 papers of different authors, most of whom are personnel from the Argentine National Atomic Energy Commission (CNEA), the others belonging to the firms involved in the development of the Argentine Nuclear Programme. The papers are arranged in 7 sections comprising the following groups of subjects; experimental and power reactors; fuel elements' fabrication study; prospection, extraction, production and study of nuclear materials; radiological and nuclear safety; instrumentation and control; quality assurance, and technological applications. (R.J.S.)

  9. Marine fronts are important fishing areas for demersal species at the Argentine Sea (Southwest Atlantic Ocean)

    Science.gov (United States)

    Alemany, Daniela; Acha, Eduardo M.; Iribarne, Oscar O.

    2014-03-01

    The high primary and secondary production associated with frontal systems attract a diversity of organisms due to high prey availability; this is why a strong relationship between fronts and pelagic fisheries has been shown worldwide. In the Argentine Sea, demersal resources are the most important, both in economical and in ecological sense; so we hypothesize that fronts are also preferred fishing areas for demersal resources. We evaluated the relationship between spatial distribution of fishing effort and oceanographic fronts, analyzing three of the most important frontal systems located in the Argentine Sea: the shelf-break front, the southern Patagonia front and the mid-shelf front. Individual vessel satellite monitoring system data (VMS; grouped by fleet type: ice-trawlers, freezer-trawlers and jigging fleet) were studied and fishing events were identified. Fishing events per area were used as a proxy of fishing effort and its spatial distribution by fleet type was visualized and analyzed with Geographic Information Systems. Oceanographic fronts were defined using polygons based on satellite chlorophyll amplitude values, and the percentage of fishing events within each polygon was calculated. Results showed a positive association between fronts and fishing activities of the different fleets, which suggests the aggregation of target species in these zones. The coupling of the freezer-trawler and jigging fleets (that operate on lower trophic level species; Macruronus magellanicus and Illex argentinus respectively) with fronts was higher than the ice-trawler fleet, targeting species of higher trophic level (Merluccius hubbsi). Marine fronts represent important fishing areas, even for demersal resources, as the distribution of fishing fleets and fishing effort are positively associated with frontal zones.

  10. Floral visitation by the Argentine ant reduces bee visitation and plant seed set.

    Science.gov (United States)

    Hanna, Cause; Naughton, Ida; Boser, Christina; Alarcón, Ruben; Hung, Keng-Lou James; Holway, David

    2015-01-01

    Ants often visit flowers, but have only seldom been documented to provide effective pollination services. Floral visitation by ants can also compromise plant reproduction in situations where ants interfere with more effective pollinators. Introduced ants may be especially likely to reduce plant reproductive success through floral visitation, but existing experimental studies have found little support for this hypothesis. Here, we combine experimental and observational approaches to examine the importance of floral visitation by the nonnative Argentine ant (Linepithema humile) on plant species native to Santa Cruz Island, California, USA. First, we determine how L. humile affects floral visitor diversity, bee visitation rates, and levels of pollen limitation for the common, focal plant species island morning glory (Calystegia macrostegia ssp. macrostegia). Second, we assess the broader ecological consequences of floral visitation by L. humile by comparing floral visitation networks between invaded and uninvaded sites. The Argentine ant and native ants both visited island morning glory flowers, but L. humile was much more likely to behave aggressively towards other floral visitors and to be the sole floral occupant. The presence of L. humile in morning glory flowers reduced floral visitor diversity, decreased rates of bee visitation, and increased levels of pollen limitation. Network comparisons between invaded and uninvaded. sites revealed differences in both network structure and species-level attributes. In. invaded sites, floral visitors were observed on fewer plant species, ants had a higher per-plant interaction strength relative to that of other visitors, and interaction strengths between bees and plants were weaker. These results illustrate that introduced ants can negatively affect plant reproduction and potentially disrupt pollination services at an ecosystem scale. PMID:26236907

  11. Therapeutic Argentine tango dancing for people living with Parkinson’s disease: a feasibility study

    Directory of Open Access Journals (Sweden)

    Laura M Blandy

    2015-05-01

    Full Text Available Background: Individuals living with Parkinson’s disease (PD can experience a range of movement disorders. Therapeutic dance is enjoyable and thought to improve mobility, balance and well being in some people with PD. The primary objective of this study was to evaluate the feasibility and safety of a 4 week Argentine tango dance program for people with PD. Methods: Six community dwelling individuals with mild-moderate PD were recruited from Parkinson’s support groups, movement disorder clinics and the Parkinson’s disease Association in Australia. To minimise falls risk, participants were required to be less than 75 years of age and physically independent (Hoehn and Yahr stages I-III. They were also required to speak English. Participants attended a 1 hour dance class at a dance studio twice per week for 4 weeks. A professional dance instructor led and choreographed the classes. Physiotherapists were present to assist participants during the class and served as dance partners as necessary. The primary outcome was feasibility which was determined by measures of recruitment, adherence, attrition, safety (falls, near misses and adverse events and resource requirements. Secondary measures included the Beck Depression Inventory and the Euroqol-5D, administered at baseline and post intervention. Therapy outcomes pre and post-intervention were analysed descriptively as medians and inter-quartile ranges and using Wilcoxon matched pair signed-rank tests.Results: The Argentine tango dance intervention was shown to be safe, with no adverse events. Adherence to the dance program was 89%. Depression scores improved after intervention (p=0.04. Some challenges were associated with the need to quickly recruitment participants and supplying physiotherapists to act as dance partners. Conclusion: The program was shown to be feasible and safe for people with mild to moderately severe PD.

  12. The effect of airborne particles and weather conditions on pediatric respiratory infections in Cordoba, Argentine

    International Nuclear Information System (INIS)

    We studied the effect of estimated PM10 on respiratory infections in children from Cordoba, Argentine as well as the influence of weather factors, socio-economic conditions and education. We analyzed upper and lower respiratory infections and applied a time-series analysis with a quasi-Poisson distribution link function. To control for seasonally varying factors we fitted cubic smoothing splines of date. We also examined community-specific parameters and differences in susceptibility by sex. We found a significant association between particles and respiratory infections. This relationship was affected by mean temperature, atmospheric pressure and wind speed. These effects were stronger in fall, winter and spring for upper respiratory infections while for lower respiratory infections the association was significant only during spring. Low socio-economic conditions and low education levels increased the risk of respiratory infections. These findings add useful information to understand the influence of airborne particles on children health in developing countries. - Highlights: ► Few information is available on children respiratory health from developing countries. ► We modeled the association between PM10 and children's respiratory infections. ► We checked the influence of weather factors, socio-economic conditions, education and sex. ► Temperature, pressure and wind speed modified the effect of particles. ► Low socio-economic conditions and low education levels increased the risk of infections. - The concentration of airborne particles as well as low socio-economic conditions and low education levels are significant risk factors for upper and lower respiratory infections in children from Cordoba, Argentine.

  13. Consequences of the Argentine ant, Linepithema humile (Mayr), invasion on pollination of Euphorbia characias (L.) (Euphorbiaceae)

    Science.gov (United States)

    Blancafort, Xavier; Gómez, Crisanto

    2005-07-01

    We have studied the influence of the Argentine ant, Linepithema humile, on the pollination of Euphorbia characias, a deciduous insect-pollinated shrub. The observations were made in two adjacent areas (invaded and non-invaded by L. humile) in a Mediterranean cork-oak forest. In the invaded area, L. humile has replaced most of the native ants that climb up this plant's inflorescences. Five native ant species were detected in the non-invaded areas and only one in the invaded area. The number of visitors to infested inflorescences (1.54 ± 1.86 visitors/10 min observation) was lower than in non-infested inflorescences in the invaded area (3.74 ± 4.19 visitors/10'), and in the non-invaded areas (4.16 ± 5.00 visits/10'). For several species of flower-visiting insects, no differences were detected between the time spent in the flowers and the number of flowers visited in the two areas, except for Eristalis tenax, a dipteran which visited more flowers (15.2 ± 11.1 flowers visited/10') and spent more time (9.4 ± 5.8 sec) in the non-invaded area than in the invaded area (7.8 ± 8.2 flowers visited/10' and 5.3 ± 2.1 sec, respectively). The relative representation of insect orders in the two areas was not different. A significant reduction in fruit-set and seed-set was detected in the invaded area. These results suggest that the Argentine ant may greatly affect the reproductive success of components of the Mediterranean flora.

  14. Can the Argentine ant ( Linepithema humile Mayr) replace native ants in myrmecochory?

    Science.gov (United States)

    Gómez, Crisanto; Oliveras, Jordi

    2003-04-01

    We analyse the influence of the Argentine ant ( Linepithema humile Mayr) on the seed dispersal process of the myrmecochorous plants Euphorbia characias, E. biumbellata, Genista linifolia, G. triflora, G. monspessulana and Sarothamnus arboreus. The observations were made in two study plots of Mediterranean cork-oak secondary forest (invaded and non-invaded by L. humile). The presence of L. humile implies the displacement of all native ant species that disperse seeds. Seed transports in the non-invaded zone were carried out by eight ant species. In the invaded zone, L. humile workers removed and transported seeds to the nest. In vertebrate exclusion trials, we observed the same level of seed removal in the invaded and non-invaded zones. Two findings could explain this result. Although mean time to seed localization was higher for native ants (431.7 s) than that for L. humile (150.5 s), the mean proportion of seeds transported after being detected was higher (50.1%) in non-invaded than in invaded (16.8%) zones. The proportion of seeds removed and transported into an ant nest after an ant-seed interaction had dramatically reduced from non-invaded (41.9%) to invaded (7.4%) zones. The levels of seed dispersal by ants found prior to invasion are unlikely to be maintained in invaded zones. However, total replacement of seed dispersal function is possible if contact iteration finally offers similar levels or quantities of seeds reaching the nests. The results obtained confirm that the Argentine ant invasion may affect myrmecochory dramatically in the Mediterranean biome.

  15. Comparative efficacy and the window of radioprotection for adrenergic and serotoninergic agents and aminothiols in experiments with small and large animals

    International Nuclear Information System (INIS)

    This review gives a comparative evaluation of the radioprotective properties and the therapeutic index (TI) of radioprotectors from various pharmacological group in experiments on both small and large animals. It presents a hypothesis explaining the decrease in the TI of cystamine and 5-methoxytryptamine (mexamine), and the retention of that of α1-adrenomimetic indralin, and also compares the effects on large and small animals. The considerable differences in the therapeutic indices of catecholamines, serotonin and cystamine are a consequence of specific features of their mechanisms of radioprotective action. Radioprotectors acting via receptor mediation tend to provide a more expanded window of protection. The reduction in the TI of cystamine in larger animals, such as dogs, may be caused by the greater increase in toxicity of aminothiols in relation to the decrease in their optimal doses for radioprotective effect in going from mice to dogs, which is a consequence of the slower metabolic processes in larger animals. The somatogenic phase of intoxication by cystamine is significantly longer than the duration of its radioprotective effect, and increases with irradiation. The decrease in the radioprotective effect and the TI of mexamine in experiments with dogs may be caused by their lower sensitivity to the acute hypoxia induced by the mexamine. This is because of lower gradient in oxygen tension between tissue cells and blood capillaries under acute hypoxia that is determined by lower initial oxygen consumption in a large animal as compared with a small animal. Indralin likely provides optimal radioprotective effects and a higher TI for large animals via the increased specificity of its adrenergic effect on tissue respiration, which supports the development of acute hypoxia in the radiosensitive tissues of large animals. The stimulatory effect of indralin on early post-irradiation haematopoietic recovery cannot provide a high level of radioprotective action for

  16. 10. Latin American Regional Congress IRPA Protection and Radiation Safety

    International Nuclear Information System (INIS)

    The 10.Latin American Regional Congress IRPA Protection and Radiation Safety was organized by the Radioprotection Argentine Society, in Buenos Aires, between the april 12 and 17, 2015. In this event, were presented almost 400 papers about these subjects: radiation protection in medicine and industry; radiological and nuclear emergencies; NORM (Natural Occurring Radioactive Materials); reactors; radiation dosimetry; radiotherapy; non-ionizing radiations; policies and communications; etc.

  17. The radioprotective effect and mechanism of captopril on radiation induced lung damage in rat

    International Nuclear Information System (INIS)

    It was reported that Captopril (angiotensin converting enzyme inhibitor) had an effect to reduce the pneumonitis and pulmonary fibrosis induced by radiation in rat. We performed this study to investigate the radioprotective effect and mechanism of Captopril. The comparison was made between the radiation only group and the combined Captopril and radiation group by examining histopathologic findings and immunohistochemical stains (TNF α and TGF β1) at 2 and 8 weeks after irradiation. Each group has 8 to 10 rats (Sprague-Dawley). 12.5 Gy of X-ray was irradiated to the left hemithorax in a single fraction. Captopril (50 mg/kg/d) mixed with water was given per oral and continuously from 1 week prior to irradiation up to 8th week of the experiment. In the combined Captopril and radiation group, the histopathologic changes which were hemorrhage into alveolar space, changes of alveolar epithelium, bronchial epithelium and blood vessels, and perivascular edema were less severe than in the radiation only group at 2 weeks. At 8 weeks, the alveolar epithelial changes and perivascular edema were less prominent in the combined Captopril and radiation group. At 2 weeks, the TNF α expression of the combined Captopril and radiation group was markedly decreased at the alveolar epithelium (p<0.01), lymphoid tissue (p=0.06) and the macrophage of alveolar space (p<0.01) compared with the radiation only group. Furthermore the TGF β1 expression was significantly prominent at the alveolar epithelium (p<0.02) and the macrophage in alveolar space (p< 0.02). At 8 weeks, the expression of TNF α and TGF β 1 of most sites, except TGF β1 of the macrophage of alveolar space (p=0.09), showed no significant difference between 2 groups. This study revealed that early lung damage induced by irradiation was reduced with the addition of Captopril in the latent and early pneumonitis phase. The expression of TNF α and TGF β 1 at 2 weeks and TGF β 1 at 8 weeks was further decreased in the

  18. The radioprotective effect and mechanism of captopril on radiation induced lung damage in rat

    Energy Technology Data Exchange (ETDEWEB)

    Song, Mi Hee; Lee, Kyung Ja; Koo, Hea Soo; Oh, Won Young [College of Medicine, Ewha Women Univ., Seoul (Korea, Republic of)

    2001-06-01

    It was reported that Captopril (angiotensin converting enzyme inhibitor) had an effect to reduce the pneumonitis and pulmonary fibrosis induced by radiation in rat. We performed this study to investigate the radioprotective effect and mechanism of Captopril. The comparison was made between the radiation only group and the combined Captopril and radiation group by examining histopathologic findings and immunohistochemical stains (TNF {alpha} and TGF {beta}1) at 2 and 8 weeks after irradiation. Each group has 8 to 10 rats (Sprague-Dawley). 12.5 Gy of X-ray was irradiated to the left hemithorax in a single fraction. Captopril (50 mg/kg/d) mixed with water was given per oral and continuously from 1 week prior to irradiation up to 8th week of the experiment. In the combined Captopril and radiation group, the histopathologic changes which were hemorrhage into alveolar space, changes of alveolar epithelium, bronchial epithelium and blood vessels, and perivascular edema were less severe than in the radiation only group at 2 weeks. At 8 weeks, the alveolar epithelial changes and perivascular edema were less prominent in the combined Captopril and radiation group. At 2 weeks, the TNF {alpha} expression of the combined Captopril and radiation group was markedly decreased at the alveolar epithelium (p<0.01), lymphoid tissue (p=0.06) and the macrophage of alveolar space (p<0.01) compared with the radiation only group. Furthermore the TGF {beta}1 expression was significantly prominent at the alveolar epithelium (p<0.02) and the macrophage in alveolar space (p< 0.02). At 8 weeks, the expression of TNF {alpha} and TGF {beta} 1 of most sites, except TGF {beta}1 of the macrophage of alveolar space (p=0.09), showed no significant difference between 2 groups. This study revealed that early lung damage induced by irradiation was reduced with the addition of Captopril in the latent and early pneumonitis phase. The expression of TNF {alpha} and TGF {beta} 1 at 2 weeks and TGF {beta} 1 at

  19. Radioprotective effect of vitamin A and selenium in mice splenic and blood lymphocytes by comet assay

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the protective effects of vitamin A and/or selenium treatments prior to whole-body irradiation in mice. This was obtained the radioprotective effect of vitamin A and selenium by evaluation of DNA damage levels in mice spleen and blood after irradiation. Six-week-old ICR male mice were administrated with vitamin A(low dose : 3.0 mg/kg, high dose : 12mg/kg) and/or selenium( low dose : 0.5 mg/kg, high dose : 2.0 mg/kg) orally once a day for 6 days and then irradiated with 8.0 Gy of γ-ray. After that, the mice were sacrificed 3 days later. Spleen and blood were taken and then lymphocytes were isolated. Spleen and blood were collected aseptically and isolated the lymphocytes by Ficollhistopaque gradient centrifugation. Cells embedded in agarose are lysed, subjected briefly to an electric field, stained with a fluorescent DNA binding stain and viewed using a fluorescence microscope. The tail moment(TM) of DNA single-strand breaks in mice splenic and blood lymphocytes were evaluated by single cell gel electrophoresis assay (Comet assay). Comet assay has been applied for detection of DNA damage due to many chemicals like environmental toxic materials. The comet assay is a novel method to assess DNA single-strand breaks, alkali-labile sites in individual cells. TM values of selenium and vitamin A in splenic lymphocytes and blood lymphocytes reduced a little compared to the irradiated control group. TM values in high administration doses of vitamin A(12mg/kg) and plus selenium(2mg/kg) reduced the most compared to low administration dose group and those of all experimental groups in blood lymphocytes. From these results, it showed that vitamin A and selenium were a little radioprotective effect in mice like other antioxidants but combined effect of these chemical in splenic lymphocytes showed a little unlike blood lymphocytes

  20. Mechanistic aspects of radioprotection by todralazine hydrochloride, a hematopoietic stem cell expanding agent

    International Nuclear Information System (INIS)

    Previously, we have reported todralazine hydrochloride, an antihypertensive drug, as a radioprotector and hematopoietic stem cell (HSC) expanding agent. The present study aims at unraveling mechanistic aspects of its radioprotective and HSC expanding potential. Zebrafish Tg (cmyb:GFP) embryos treated with 5 μM todralazine from 24-36 hours post fertilization (hpf), increased the number of HSCs (∼ 2 folds) at aorta gonad mesonephros (AGM) region. Similarly, the expression of HSC marker genes, runx1 (3.3 folds) and cMyb (1.4 folds) were also found to be increased. Further, todralazine also accelerated hematopoietic lineage production, erythropoiesis, as evaluated in chemical induced anemic model in zebrafish. Genome wide expression changes in todralazine treated embryos (from 24-36 hpf) using microarray, revealed up and down regulation of 645 and 429 genes respectively. Pathway analysis using DAVID database strongly suggested up regulation of wnt pathway (p<0.019253), which is known to involve in HSC expansion, in todralazine pre-treated embryos. NOS1, known to have its role in HSC expansion through wnt pathway, has been significantly upregulated (1.54 folds; q PCR) by todralazine treatment (from 24-36 hpf). Todralazine treatment (∼30 minutes; 20 Gy) led to a significant upregulation of antioxidant genes (SOD, catalase), DNA damage response genes (p53, p21, GADD45) and nucleotide excision repair genes (XPC, XPA, XPF, XPD) when compared to irradiated control. Immunohistochemical analysis of DNA damage marker (γH2AX) (30 minutes post irradiation), further supported radiation induced DNA damage and protection by todralazine pre-treatment. Corroborating these results, pre-irradiation treatment of todralazine reduced radiation induced apoptosis (caspase 3 assay). Overall, the results suggest that, todralazine protects zebrafish from radiation induced damages by upregulating antioxidant defense system, DNA damage recognition, DNA repair machinery and by reducing cell

  1. Study of radio-protective effects of ascorbic acid in rates

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the potential radio-protective effects of different ascorbic acid concentrations (vitamin C) in rats before whole body irradiation with total dose of 7 Gy (60Co source) using two different dose rates of 1 and 0.55 Gy.min-1 by increasing percent of surviving. In the first group (1 Gy/m); rats were administered four different concentrations of ascorbic acid (7.5, 12.5, 100, 200 mg/kg b wt ) in drinking water for 30 days before irradiation starting from the ablactation which considered as day 0. Whereas, in the second group (0.55 Gy/m); rats were administered six different concentrations of ascorbic acid (1, 5, 7.5, 12.5, 100, 200 mg/kg b wt) before irradiation with total dose 7 Gy (60Co source). The results have showed that the ascorbic acid enhance the 30-day survival of irradiated rats in 1 and 0.55 Gy/m groups, compared to the control group. The mean cumulated probability of survival of rats (1 Gy/m group) was 66%± 6 (Mean± S.E), 69%± 5, 52%± 9 and 51%± 9 in groups of rats which administered 7.5, 12.5, 100, 200 mg/kg, respectively, versus 41%± 9 in control group for 14 days. While, it was 90%± 2, 90%± 2, 88%± 2, 94%± 1, 84%± 3 and 78%± 3 in groups of rats which administered 1, 5, 7.5, 12.5, 100, 200 mg/kg respectively, versus 52%± 6 in control group for 30 days. Our data, also, indicated that all ascorbic acid concentrations in both groups had significant reduction in mortality and increasing percent of surviving compared to the control groups. We conclude that all ascorbic acid concentrations which used in both groups (1 and 0.55 Gy/m), had radioprotective effects in rats when administrated before irradiations, and this role was more effective against lower dose rate of radiation exposure. (author)

  2. Human fibroblast growth factor 20 (FGF-20; CG53135-05): a novel cytoprotectant with radioprotective potential.

    Science.gov (United States)

    Maclachlan, T; Narayanan, B; Gerlach, V L; Smithson, G; Gerwien, R W; Folkerts, O; Fey, E G; Watkins, B; Seed, T; Alvarez, E

    2005-08-01

    The aim was to evaluate the radioprotective properties of recombinant human fibroblast growth factor 20 (FGF-20; CG53135-05) in vitro and in vivo and to examine its effects on known cellular pathways of radioprotection. Relative transcript levels of the cyclooxygenase 2 (COX2), Mn-super oxide dismutase (SOD), CuZn-SOD, extracellular (EC)-SOD, nuclear respiratory factor 2 (Nrf2), glutathione peroxidase 1 (GPX1) and intestinal trefoil factor 3 (ITF3) genes, which are involved in radiation response pathways, were assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) in NIH/3T3, IEC18, CCD-18Co, CCD-1070sk and human umbilical vein endothelial cells (HUVEC) cells exposed to FGF-20. Activation of the radioprotective signal transduction pathways initiating with the serine/threonine Akt kinase and the extracellular regulated kinase (ERK) were analysed. Levels of intracellular hydrogen peroxide and cytosolic redox potential were also measured in irradiated and unirradiated cells in the presence or absence of FGF-20. The effects of FGF-20 on cell survival in vitro following ionizing radiation were evaluated using clonogenic assays. To test the potential activity of FGF-20 as a radioprotectant in vivo, mice were administered a single dose of FGF-20 (4 mg kg(-1), intraperitoneally (i.p.) 1 day before lethal total-body irradiation and evaluated for survival. In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways (ERK and Akt) and resulted in increased survival of irradiated cells in vitro. FGF-20 treatment also resulted in a concomitant reduction in intracellular levels of injurious reactive oxygen species (ROS) following acute ionizing irradiation. Finally, prophylactic administration of FGF-20 to mice before potentially lethal, whole-body X-irradiation led to significant increases in overall survival. FGF-20 reduced the lethal effects of acute

  3. Human fibroblast growth factor 20 (FGF-20; CG53135-05): a novel cytoprotectant with radioprotective potential.

    Science.gov (United States)

    Maclachlan, T; Narayanan, B; Gerlach, V L; Smithson, G; Gerwien, R W; Folkerts, O; Fey, E G; Watkins, B; Seed, T; Alvarez, E

    2005-08-01

    The aim was to evaluate the radioprotective properties of recombinant human fibroblast growth factor 20 (FGF-20; CG53135-05) in vitro and in vivo and to examine its effects on known cellular pathways of radioprotection. Relative transcript levels of the cyclooxygenase 2 (COX2), Mn-super oxide dismutase (SOD), CuZn-SOD, extracellular (EC)-SOD, nuclear respiratory factor 2 (Nrf2), glutathione peroxidase 1 (GPX1) and intestinal trefoil factor 3 (ITF3) genes, which are involved in radiation response pathways, were assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) in NIH/3T3, IEC18, CCD-18Co, CCD-1070sk and human umbilical vein endothelial cells (HUVEC) cells exposed to FGF-20. Activation of the radioprotective signal transduction pathways initiating with the serine/threonine Akt kinase and the extracellular regulated kinase (ERK) were analysed. Levels of intracellular hydrogen peroxide and cytosolic redox potential were also measured in irradiated and unirradiated cells in the presence or absence of FGF-20. The effects of FGF-20 on cell survival in vitro following ionizing radiation were evaluated using clonogenic assays. To test the potential activity of FGF-20 as a radioprotectant in vivo, mice were administered a single dose of FGF-20 (4 mg kg(-1), intraperitoneally (i.p.) 1 day before lethal total-body irradiation and evaluated for survival. In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways (ERK and Akt) and resulted in increased survival of irradiated cells in vitro. FGF-20 treatment also resulted in a concomitant reduction in intracellular levels of injurious reactive oxygen species (ROS) following acute ionizing irradiation. Finally, prophylactic administration of FGF-20 to mice before potentially lethal, whole-body X-irradiation led to significant increases in overall survival. FGF-20 reduced the lethal effects of acute

  4. Refractions of Civil Society

    DEFF Research Database (Denmark)

    Kuzmanovic, Daniella

    The thesis investigates various perceptions of civil society among civic activists in Turkey, and how these perceptions are produced and shaped. The thesis is an anthropological contribution to studies of civil society in general, as well as to studies on political culture in Turkey....

  5. Fieldwork in Transforming Societies

    DEFF Research Database (Denmark)

    Clark, Ed; Michailova, Snejina

    The contributors to this text discuss the personal and professional challenges of conducting fieldwork in the difficult, sometimes threatening contexts of the transforming societies of post-socialist Europe and China.......The contributors to this text discuss the personal and professional challenges of conducting fieldwork in the difficult, sometimes threatening contexts of the transforming societies of post-socialist Europe and China....

  6. Civil Society and Governance

    DEFF Research Database (Denmark)

    Hulgård, Lars

    An illustration of how important the relationship is between civil society anbd governance. A short historic journey with four snapshots of times and situations that have provided interesting evidence about the connection between civil society and governance. My goal for the short historic journe...... is to make clear and hopefully even verify that providing knowledge about the impact of civil society and citizens’ participation on governance is one of the most urgent research tasks in the current period of time.......An illustration of how important the relationship is between civil society anbd governance. A short historic journey with four snapshots of times and situations that have provided interesting evidence about the connection between civil society and governance. My goal for the short historic journey...

  7. Induction of radiation resistance and radio-protective mechanism. On the reactive oxygen and free radical

    International Nuclear Information System (INIS)

    Radical scavenging system for reactive oxygen species (ROS) leading to radio-protection is reviewed on findings in animals, tissues and cells. Protection against oxygen toxicity in evolution can be seen in anaerobes' superoxide dismutase (SOD) over 3500 million years ago. ROS is generated endogenously and also by radiation. However, the intracellular sites of the generated ROS are different depending on its cause. The protection is done through enzymes like SOD, peroxidase, catalase, glutathione-related enzymes and through substances like GSH, α-tocopherol, ascorbic acid etc. Induction of ROS scavenging substances related with radio-resistance includes the responses to the low dose radiation (5-50 cGy) in those enzymes described above; to middle to high dose radiation (1-30 Gy) in a similar and in other unknown mechanisms; to exposure of ROS like H2O2 at low concentration; and to antioxidant treatment. The cross-resistance between radiation and drugs suggests necessity of this induction. (N.I.)

  8. Radioprotective effects of hawthorn fruit extract against gamma irradiation in mouse bone marrow cells

    International Nuclear Information System (INIS)

    The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1 h prior to gamma irradiation (2 Gy) reduced the frequencies of micronucleated polychromatic erythrocytes (MnPCEs). All four doses of hawthorn extract significantly reduced the frequencies of MnPCEs and increased the PCE/PCE+NCE ratio (polychromatic erythrocyte/polychromatic erythrocyte+normochromatic erythrocyte) in mice bone marrow compared with the non drug-treated irradiated control (p<0.02-0.00001). The maximum reduction in MnPCEs was observed in mice treated with extract at a dose of 200 mg/kg. Administration of amifostine at dose 100 mg/kg and hawthorn at dose 200 mg/kg reduced the frequency of MnPCE almost 4.8 and 5.7 fold; respectively, after being exposed to 2 Gy of gamma rays, compare with the irradiated control group. Crataegus extract exhibited concentration-dependent activity on 1, 1-diphenyl 2-picrylhydrazyl free radical showing that Crataegus contained high amounts of phenolic compounds and the high performance liquid chromatography (HPLC) analysis determined that it contained chlorogenic acid, epicatechin and hyperoside. It appeared that hawthorn extract with antioxidant activity reduced the genotoxicity induced by gamma irradiation in bone marrow cells. (author)

  9. [Radioprotective effect of helium-neon laser radiation for fibroblast cells].

    Science.gov (United States)

    Voskanian, K Sh; Mitsyn, G V; Gaevskiĭ, V N

    2007-01-01

    Effects of combined exposure to 633-nm laser waves and gamma-radiation, and laser waves and protons with the energy of 150 MeV on survivablilty of mice fibroblast cells C3H10T1/2 were compared. Cell suspension (1 - 5 x 10(5) cells/ml) was distributed in 2-ml plastic vials with 1 cm in diameter time interval between two exposures in a combination was no more than 60 s. immediately after exposure a required quantity of cells was inoculated in special vials for survivability assessment. Based on results of the experiment, preliminary and repeated laser treatment was favorable to survivability of fibroblast cells subjected to gamma- or proton irradiation (dose variation factor was within 1.3 to 2.2). Simultaneous exposure of C3H10T1/2 cells to the laser and proton beams also increased their survivability. The radioprotective effect of the helium-neon laser on fibroblasts earlier exposed to ionizing radiation is of chief interest, as most of the present-day radioprotectors are effective only if introduced into organism prior to exposure.

  10. Physique appliquée à l’exposition externe dosimétrie et radioprotection

    CERN Document Server

    Antoni, Rodolphe

    2013-01-01

    Cet ouvrage fait la synthèse de nombreuses années d'expériences en dosimétrie et techniques de protection contre l’exposition externe, aussi bien dans le domaine industriel que médical. Il rappelle les concepts physiques de base puis propose un certain nombre d'outils d’évaluation des nuisances radiologiques, et les moyens de s'en prémunir, en détaillant notamment les techniques de calcul pour des blindages appropriés. Le premier chapitre traite de la définition des grandeurs radiométriques et dosimétriques fondamentales. Il permet d’aborder au chapitre 2 la question de l'interaction rayonnement-matière sous un angle dédié au dépôt de la dose dans les tissus biologiques. Le troisième chapitre définit quant à lui les grandeurs de protection et les grandeurs opérationnelles liées à la radioprotection. Dans les deux chapitres suivants, l’accent a été mis sur la définition des risques et contre-mesures associées (i.e. protections biologiques) inhérents aux sources de rayonnemen...

  11. Radioprotective effect of thiola on radiation induced functional and structural changes in rat intestine

    International Nuclear Information System (INIS)

    The possible role of the sulphydryl compound (thiola) as a radioprotector against gamma radiation-induced changes in the rat intestine has been studied. Animals were subjected to different doses of radiation, namely 2, 4, 6, and 10 Gy. Intestinal glucose absorption, alkaline phosphatase enzyme activity were measured and histopathological examination were performed at 1, 3, 7 and 14 days postirradiation. Our results reveal that whole body gamma irradiation induced reduction of glucose absorption and alkaline phosphatase activity which was more pronounced on the third day after exposure. Damage to the intestine was mild after exposure to 2 and 4 Gy, manifested as oedema and congestion in addition to pyknosis of the nuclei of basal cells, while villus sloughing and necrosis of basal cells were observed 3 days after exposure to 6 and 10 Gy. It could be concluded that pretreatment of animals with thiola 30 min before exposure to radiation offered a significant radioprotective effect resulting in recovery of most of the parameters studied within 14 days

  12. Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Deborah Queiroz de; Neves, Ellen Gaby; Boscolo, Frab Norberto; Almeida, Solange Maria de [University of Campinas (UNICAMP), Piracicaba, SP (Brazil). Piracicaba Dental School. Department of Oral Diagnosis. Oral Radiology Area; Ramos-Perez, Flavia Maria de Moraes [Federal University of Pernambuco, Recife, PE (Brazil). Department of Clinical and Preventive Dentistry; Marques, Marcelo Rocha [University of Campinas (UNICAMP), Piracicaba, SP (Brazil). Piracicaba Dental School. Division of Histology. Department of Morphology

    2012-07-01

    This study evaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity. (author)

  13. Workplace analysis and radiation protection; L'etudes de poste et radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Le Guen, B.; Bosquet, Ph.; Chevillard, S.; Gauron, Ch.; Lallemand, J.; Lombard, J.; Menetrier, F.; Feuardent, J.; Maccia, C.; Donadille, L.; Rehel, J.L.; Donnarieix, D.; Garrigou, A.; Gauthereau, V.; Truchi, F.; Chardin, J.; Debouck, F.; Clairand, I.; Amabile, J.Ch.; Vrigneaud, J.M.; Roussille, F.; Witschger, O.; Feuardent, J.; Scanff, P.; Rannou, A.

    2010-07-01

    This document gathers the slides of the available presentations given during this conference day. Fifteen presentations out of 16 are assembled in the document and deal with: 1 - the evolution of doses received by workers (J. Feuardent); 2 - evaluation of extremities dosimetry among interventional radiology practitioners (L. Donadille); 3 - practical guide for the realisation of workplace dosimetry studies presenting a ionizing radiation exposure risk: and example in nuclear medicine (J.L. Rehel); 4 - workplace studies in radiotherapy-curietherapy (D. Donnarieix); 5 - from dosimetry to physical intensity: the case of heat insulation activities (A. Garrigou and C. Piccadaci); 6 - the consideration of human factor during facility modifications (V. Gauthereau); 7 - how to carry out a workplace analysis in gamma-graphy? (F. Truchi); 8 - workplace studies in the framework of dismantling activities (J. Chardin); 9 - team synergy (F. Debouck); 10 - adaptation of individual dosimetry to the workplace: the case of external exposure (I. Clairand); 11 - technical aspects of the evaluation of ionizing radiations exposure induced by a new interventional radiology procedure (J.C. Amabile); 12 - the point of view of a radioprotection skilled person in a nuclear medicine service (J.M. Vrigneaud); 13 - workplace studies for the unique document (F. Roussille); 14 - occupational exposure to manufactured nano-particles: issues and knowledge status (O. Witschger); 15 - toxicological risk of nano-particles: 'health impact'? (S. Chevillard). (J.S.)

  14. Radioprotective potential of a novel therapeutic formulation of oligoelements Se, Zn, Mn plus Lachesis muta venom

    International Nuclear Information System (INIS)

    In this study we evaluated in vivo the tolerance induced by the combination of Se, Zn and Mn (4 μg/ml each) plus Lachesis muta venom (4 ng/ml) (O-LM) to high doses of ionizing radiation. The protective effect of O-LM was investigated on the small-intestine and bone marrow of mice irradiated with a single whole-body dose of 10 Gy employing a 137Cs source. Mice were sacrificed 3 days after irradiation. Mice receiving a subcutaneous daily O-LM injection starting 30 days before irradiation, showed a higher number of crypts, enhanced villous conservation and lack of edema or vascular damage in comparison to the untreated and irradiated group. In addition, O-LM treatment decreased vascular damage and the grade of aplasia preserving medullar progenies induced by ionizing radiation on mouse bone marrow. The protective effect of O-LM against radiation injury to the small intestine was associated with an increase in proliferation and a reduction of apoptosis in intestinal crypts and furthermore, to an enhanced intestinal immunoreactivity of MnSOD, and CuZnSOD, and also catalase. Based on the present results and taking into account that O-LM is being safely administered in phase I clinical trial as an immunomodulator, we suggest that O-LM could be an attractive candidate as a safe radioprotective agent for patients undergoing radiotherapy. (author)

  15. Radioprotection of Wistar Rat Lymphocytes Against Microwave Radiation Mediated by Bee Venom

    International Nuclear Information System (INIS)

    Microwave radiation is a type of non-ionising electromagnetic radiation present in the environment, and is a potential threat to human health. Cytogenetic studies of microwave radiation conducted in vitro and in vivo, yielded contradictory and often intriguing experimental results. Some reports suggest that exposure of human cells to radiofrequency radiation does not result in increased cytogenetic damage. On the other hand, there is a range of studies showing that radiofrequency radiation can indeed induce genetic alteration after exposure to electric field. Bee venom is used in traditional medicine to treat variety of conditions, such as arthritis, rheumatism, back pain and skin disease. In recent years it has been reported that bee venom possesses antimutagenic, proinflammatory, anti-inflammatory, antinociceptive, and anticancer effects. In addition to the wide range of the bee venom's activities, it also possesses a radioprotective capacity that was noted against X-ray and gamma radiation in various test systems. The aim of the present study was assessment of the radioprotective effect of bee venom against 915 MHz microwave radiation-induced DNA damage in the Wistar rat's lymphocytes in vitro. The possible genotoxic effect of bee venom alone was also assessed on non-irradiated lymphocytes. The alkaline comet assay was used as a sensitive tool in The assessment of DNA damage was performed using the alkaline comet assay and the Fpg-modified comet assay that is more specific technique in detection of DNA strand breaks and oxidative stress. Whole blood was collected from adult male Wistar rats (11 weeks old, approximate body weight 350 g)by cardiac puncture under sterile conditions in heparinized vacutainer tubes. After collection, blood was divided into 1 ml aliquots and placed into 24-well culture plates according to the exposure conditions. Bee venom was added to lymphocyte cultures in final concentration of 1 μg/ml, 4 h prior to irradiation and immediately

  16. Radioprotective effects of (-)-epigallocatechin-3-gallate on human erythrocyte/granulocyte lineages

    International Nuclear Information System (INIS)

    Epigallocatechin-3-gallate (EGCg) is widely recognised as a powerful antioxidant and free radical scavenger. This study examined the radioprotective effects of EGCg on human granulopoiesis and erythropoiesis. Highly purified human CD34+ haematopoietic stem/progenitor cells were prepared from human placental/umbilical cord blood. The cells were exposed to X rays at a dose rate of ∼1 Gy min-1 and then cultured in a medium supplemented with either granulocyte colony-stimulating factor (G-CSF) or erythropoietin (EPO). EGCg (100 nM) was added to the culture immediately before or after X-irradiation. The concentration of 100-nM EGCg was determined in the authors' previous study. The number of granulocyte and erythrocyte colonies generated by X-irradiated CD34+ cells decreased in a dose-dependent manner. Although EGCg addition yielded an ∼2-fold increase in the proliferation of each haematopoietic progenitor, no significant protective effect was observed in the surviving fraction of granulocyte progenitors (G-CSF alone: D051.06 Gy, n51.14). However, EGCg addition before or after irradiation conferred a significantly higher protective effect on erythrocyte colony formation compared with the control (EPO alone: D050.66 Gy, n51.56; EGCg (before): D050.43 Gy, n55.48). EGCg addition before irradiation significantly improved the survival of erythroid progenitors subjected to radiation of <1 Gy. These results suggest that EGCg is more protective of erythropoiesis than granulopoiesis from radiation damage. (authors)

  17. Contamination and cancers: low-dose risks and standards of radioprotection

    International Nuclear Information System (INIS)

    Irradiation of the population due to the running of nuclear power stations represents less than 1% of the natural radioactivity today, and should amount to 3% at most by the year 2 000. The main effects of ionizing radiations are reviewed and their undetectability below 100 rems is underlined. Thus the evaluation of low-dose risks can only be speculative and the cautions hypothesis adopted is that of a linear relationship between dose and effect, together with the absence of threshold. According to calculations the worker, supposedly exposed to 500 mrem a year between ages 18 and 65, would run a 22.2% instead of the normal 22% risk of dying of cancer. As for the population, the risk would increase by only 1 per 10 000 in the year 2 000. This means that no other mutagenic and carcinogenic agent is as well regulated as radioactive pollution and efforts directed at a better control of harmful chemicals, for instance, are only taking an example from the ruling on radioprotection

  18. Radioprotective effect of Ganoderma lucidum (Leyss. ex. Fr. ) Karst after X-ray irradiation in mice

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, H.Y.; Lian, S.L.; Lin, C.C. (Kaohsiung Medical College (Taiwan))

    1990-01-01

    Six to seven week old male mice of ICR strain were exposed to 500 or 650 cGy of X-ray during experiments to determine if Ganoderma lucidum could be a factor in modification of radiation damage. Continuous intraperitoneal injection of the extract from Ganoderma lucidum before or after irradiation of 500 and 650 cGy of X-ray was found to improve the 30-day survival fractions of ICR mice, but wasn't significant by statistical analysis. The administration also enhanced the recoveries of the body weights and increased the recovery of hemograms of irradiated mice from radiation damage by injecting before or after radiation exposure, especially for the treatment of 500 cGy irradiation. The 10-day CFUs was significantly higher for Ganoderma lucidum treated groups than for untreated groups. However, the differences of radioprotective effect between the X-ray irradiated groups with Ganoderma lucidum pretreated and post-treated were not significant (p greater than 0.05).

  19. Radioprotective effects of Aloe vera leaf extract on skin of Swiss mice after gamma irradiation

    International Nuclear Information System (INIS)

    Full text: Biological effects of radiation are detrimental to life. Skin being a cell-renewal system is one of the best organ for studying radiation induced effects and their modulation by antioxidants. An attempt has been made to evaluate radioprotective efficacy of Aloe vera leaf extract on skin in Swiss mice (1g/kg body wt/day). The mice selected from inbreed colony were divided into two groups. The first group was given Aloe vera extract orally for 15th consecutive days and served as experimental group while the other group received DDW (vol. equal to Aloe extract) to serve as control group. On the 15th day, after 30 min of above treatment animals of both the groups were exposed to 2 Gy gamma irradiation and autopsied on 6h 1, 3, 7, 14 and 21 days. DNA as well as total protein decreases in control group as compared to the normal value. Surprisingly, in experimental group, DNA and protein increases in comparison to the control group. Thus, Aloe vera were found to have positive influence against radiation induced alterations on skin of Swiss albino mice

  20. Research concerning the radioprotective and immunostimulating effects of deuterium-depleted water

    International Nuclear Information System (INIS)

    Mice fed during 15 days with deuterium-depleted water (30 ppm deuterium) had a statistically significant increased survival compared with control group fed with normal distilled water (150 ppm deuterium) after 8.5 Gy irradiation (61% survival in rest group towards 25% in control group). Hematological picture showed maintaining of the normal WBC, RBC, and platelet count in test groups. Immunological parameters (serum opsonic and bactericidal capacity, bactericidal capacity of the peritoneal macrophages) showed a marked increase in test groups compared to a severe decrease in the control groups. Auxiliary tests using radiomimetic chemicals (hydrochloric embihine) and immunosupressors (cyclophosphamide) showed a strong protective effect of deuterium-depleted water against the decrease of the leukocyte counts and other immunologic parameters. In conditions of experimental inflammation with subcutaneous-implanted pellets, deuterium-depleted water feeding statistically significant increased inflammatory response, obviated by increased percentages of PMN and lymphocytes in the peripheral blood and increased phagocytic capacity of the peripheral blood PMN. Experimental infections with K. pneumoniae 506 and S. pneumoniae 558 in mice irradiated or treated with cyclophosphamide showed increased non-specific immunity parameters. All results showed a marked intensification of the immune defenses and increased proliferation of the peripheral blood cells, probably accounting for the radioprotective effects. (authors)

  1. Radioprotective Action of Low-Intensity Light into the Red Absorption Band of Endogenous Molecular Oxygen

    Science.gov (United States)

    Ivanov, A. V.; Mashalov, A. A.; Zakharov, S. D.

    2016-08-01

    Application of ionizing radiation in oncology (radiation therapy) is a widespread way to eliminate malignant tumors. Normal tissues are inevitable included in any radiation field, and their reliable protection is actual till now. All attempts to solve the problem are based on search of effective radioprotectors, i.e. chemical compounds of various classes, which should be entered into the patient. To date about 50,000 compounds with some radioprotection properties had been tested, but the most effective of them have been simultaneously the most toxic. Here the preliminary results of researches devoted to development of an optical technique on basis of the light-oxygen effect for the protection of women with breast cancer from side effects of the radiation therapy are presented. A low intensity emission of the semiconductor laser in a red spectral interval was used to excite a very small quantity of endogenous molecular oxygen in O2(1Δg) state. It is shown, that application of the method at occurrence of earliest signs of radiation injury allows notably reducing dangerous breaks in radiation therapy course.

  2. Recent trends in radioprotection dosimetry: Promising solutions for personal neutron dosimetry

    International Nuclear Information System (INIS)

    In this paper new detecting methods will be described, which are very sensitive to fast neutrons and are completely insensitive to gamma radiations. These new detectors are based on the same properties of highly ionizing particles which determine their high biological effectiveness, namely the high deposition of energy at microscopic and submicroscopic distances from the particle trajectory in solid materials. Another important characteristic, common to these new detecting methods, is the exploitation of the high-energy deposition in the vicinity of the track to initiate avalanche-type of processes, which can be easily detected. These new registration techniques are respectively the electrochemically etched damage track detectors and the bubble damage polymer detectors. The simplicity, low cost and small size of these new detecting systems, together with their high sensitivity and their ability to discriminate against large fluxes of sparsely ionizing radiations make it possible to tackle some of the most difficult problems yet to be solved in radioprotection monitoring, such as personnel neutron dosimetry. (orig./HSI)

  3. The effects of selenium on glutathione peroxidase activity and radioprotection in mammalian cells

    International Nuclear Information System (INIS)

    The media of representative mammalian cell lines were supplemented with low levels of selenium in the form of sodium selenite in order to investigate the effects of selenium on mammalian cells. Following incubation in 30 nM sodium selenite, these cells were assayed for changes in glutathione peroxidase (GPx) activity. The cells examined included NIH 3T3 mouse fibroblasts, PC12 rat sympathetic precursor cells, SupT-1 human lymphocytes, MCF-7adr human breast carcinoma cells and AA8 Chinese hamster ovary cells. Selenium supplementation resulted in a marginal increase in GPx activity for the NIH 3T3, MCF-7adr and Supt-1 cells but stimulated GPx activity approximately 5-fold in PC12 and AA8 cells. AA8 cells were selected to evaluate whether selenium supplementation was radioprotective against 60cobalt gamma irradiation. Protection against radiation-induced mutation was measured by evaluating mutation frequency at the hprt locus. In this assay, preincubation of AA8 CHO cells significantly protected these cells from exposure to 8 Gy

  4. Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds

    International Nuclear Information System (INIS)

    The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of γ-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mgkg-1 body weight of propolis (water or ethanolic extract; water-soluble derivative of propolis (WSDP) or ethanolic extract of propolis (EEP)) or its polyphenolic compounds (quercetin, naringin caffeic acid, chrysin) consecutively for 3 d before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness. All test compounds provided protection against hematopoietic death (death within 30 d after irradiation). The greatest protection was achieved with quercetin; the number of survivors at the termination of the experiment was 63%. According to statistical analyses by the Kaplan-Meier method and the log-rank test, a significant difference between test components and control was found (p<0.001). Treatment with test components after lethal irradiation was ineffective. These results suggest that propolis and its polyphenolic compounds given to mice before irradiation protect mice from the lethal effects of whole-body irradiation. (author)

  5. Mémoire d’un saccage. Argentine, le hold-up du siècle

    Directory of Open Access Journals (Sweden)

    Julien Welter

    2005-02-01

    Full Text Available Memoria del saqueo – la oscura trama de la corrupcion Documentaire argentin de Fernando SOLANAS, 2004, 120mn. Sortie de la dictature, l’Argentine ne pensait jamais connaître une nouvelle fois le cauchemar d’un désastre social. Ce pays, naguère le plus riche d’Amérique du Sud, a en effet tout tenté pour s’éloigner des régimes autoritaires conduisant à l’asservissement du peuple. Tout tenté, même l’extrême opposé, l’ultralibéralisme. En revenant sur ces années d’une politique en apparence ouver...

  6. Nestor Kirchner (2003-2007) : rupture ou continuite du peronisme ? Les mutations du populisme en Argentine

    OpenAIRE

    Doz, Emilie

    2015-01-01

    Ce texte est un extrait du quatrième chapitre de la thèse « Néstor Kirchner (2003-2007) : Rupture ou continuité du péronisme. Les mutations du populisme en Argentine ». Le 25 mai 2003, le peuple argentin assistait à l’investiture présidentielle du candidat du Frente Para la Victoria, Néstor Kirchner. Suite à la défection de Carlos Menem pendant l’entre-deux tours, il est élu avec 22% des suffrages. Malgré cette faible légitimité, il réussit à insuffler un changement certain dans la politique ...

  7. Motives for inter-firm cooperation on R&D and innovation: empirical evidence from Argentine and Spain

    OpenAIRE

    Edwards-Schachter, Mónica; Anlló, Guillermo; Castro-Martínez, Elena; Sánchez-Barrioluengo, Mabel; Fernández de Lucio, Ignacio

    2012-01-01

    Motives and determinants supporting inter-firm technological cooperation have been extensively investigated in developed countries but scarcely addressed in developing countries. This paper addresses these issues, investigating empirically several factors influencing the likelihood to cooperate on R&D and innovation between Argentine and Spanish firms, their strategic motives and firms characteristics which influence cooperation. We draw upon data collected through a survey of 104 firms and c...

  8. Workers select mates for queens: a possible mechanism of gene flow restriction between supercolonies of the invasive Argentine ant

    Science.gov (United States)

    Sunamura, Eiriki; Hoshizaki, Sugihiko; Sakamoto, Hironori; Fujii, Takeshi; Nishisue, Koji; Suzuki, Shun; Terayama, Mamoru; Ishikawa, Yukio; Tatsuki, Sadahiro

    2011-05-01

    Some invasive ants form large networks of mutually non-aggressive nests, i.e., supercolonies. The Argentine ant Linepithema humile forms much larger supercolonies in introduced ranges than in its native range. In both cases, it has been shown that little gene flow occurs between supercolonies of this species, though the mechanism of gene flow restriction is unknown. In this species, queens do not undertake nuptial flight, and males have to travel to foreign nests and cope with workers before gaining access to alien queens. In this study, we hypothesized that male Argentine ants receive interference from workers of alien supercolonies. To test this hypothesis, we conducted behavioral and chemical experiments using ants from two supercolonies in Japan. Workers attacked males from alien supercolonies but not those from their own supercolonies. The level of aggression against alien males was similar to that against alien workers. The frequency of severe aggression against alien males increased as the number of recipient workers increased. Cuticular hydrocarbon profiles, which serve as cues for nestmate recognition, of workers and males from the same supercolony were very similar. Workers are likely to distinguish alien males from males of their own supercolony using the profiles. It is predicted that males are subject to considerable aggression from workers when they intrude into the nests of alien supercolonies. This may be a mechanism underlying the restricted gene flow between supercolonies of Argentine ants. The Argentine ant may possess a distinctive reproductive system, where workers participate in selecting mates for their queens. We argue that the aggression of workers against alien males is a novel form of reproductive interference.

  9. Communication of 31 March 2000 received from the Permanent Mission of the Argentine Republic to the International Atomic Energy Agency

    International Nuclear Information System (INIS)

    The document reproduces the text of a letter dated 31 March 2000 from the Resident Representative of the Argentine Republic, including as attachment the declaration of the Advisory and Political Harmonisation Forum of MERCOSUR (Argentina, Brazil, Paraguay, Uruguay), Bolivia and Chile, issued on 27 March 2000, with regard to the 30th Anniversary of the entry into force of the Treaty on the Non-Proliferation of Nuclear Weapons

  10. Moderls of Internationzation of Two Argentine Pharmaceutical Companies in Historical Perspective: The Cases of Bagó and Sidus

    OpenAIRE

    Campins, Mónica

    2015-01-01

    Internationalization is not a simple decision but rather a complex strategy that requires the presence of tangible and intangible resources that, in the case of a family firm, call for careful analysis. To understand this process, the present study reconstructs the historical trajectories of two important Argentine laboratories, Bagó and Sidus, in historical perspective, using the stage approach of the Uppsala school (U-model) and the perspective of resources and capacities (resource-based vi...

  11. Molina’s Touch and Dorda’s Music: The Schizophrenia of Gender in Post-dictatorial Argentine Fiction

    OpenAIRE

    Bhaumik, Munia

    2008-01-01

    This paper proposes to analyze the “woman question” in relation to tropes of schizophrenia in post-dictatorial queer Argentine fiction. Gilles Deleuze and Felix Guttari’s claim in Anti-Oedipus: Capitalism and Schizophrenia states: “schizoanalysis must devote itself with all its strength to the necessary destructions….. Destroying beliefs and representations, theatrical scenes. And when engaged in this task no activity will be too malevolent.” Similarly, Manuel Puig’s El Beso de la mujer ...

  12. Samosprávné podniky v Argentině jako sociální hnutí

    OpenAIRE

    Virtová, Tereza

    2011-01-01

    This thesis aims to elaborate a case study of self-managed factories, which has been emerging in Argentina after the economic crisis in 2001. Mainly the conflictive origin, organization, role of the state and the dynamics of the movement of self-managed factories is discussed. This paper is based on European tradition of social movements' analysis and seeks to characterize movement of Argentine self-managed factories as so called old or new social movement. This dividing line will ultimately ...

  13. Accountability and non-proliferation nuclear regime: a review of the mutual surveillance Brazilian-Argentine model for nuclear safeguards

    International Nuclear Information System (INIS)

    The regimes of accountability, the organizations of global governance and institutional arrangements of global governance of nuclear non-proliferation and of Mutual Vigilance Brazilian-Argentine of Nuclear Safeguards are the subject of research. The starting point is the importance of the institutional model of global governance for the effective control of non-proliferation of nuclear weapons. In this context, the research investigates how to structure the current arrangements of the international nuclear non-proliferation and what is the performance of model Mutual Vigilance Brazilian-Argentine of Nuclear Safeguards in relation to accountability regimes of global governance. For that, was searched the current literature of three theoretical dimensions: accountability, global governance and global governance organizations. In relation to the research method was used the case study and the treatment technique of data the analysis of content. The results allowed: to establish an evaluation model based on accountability mechanisms; to assess how behaves the model Mutual Vigilance Brazilian-Argentine Nuclear Safeguards front of the proposed accountability regime; and to measure the degree to which regional arrangements that work with systems of global governance can strengthen these international systems. (author)

  14. Climate and Ancient Societies

    DEFF Research Database (Denmark)

    Climate, and human responses to it, have a strongly interconnected relationship. This when climate change occurs, the result of either natural or human causes, societies should react and adapt to these. But do they? If so, what is the nature of that change, and are the responses positive...... or negative for the long-term survival of social groups? In this volume, scholars from diverse disciplines including archaeology, geology and climate sciences explore scientific and material evidence for climate changes in the past, their causes, their effects on ancient societies and how those societies...

  15. Fairness in society

    CERN Document Server

    Flomenbom, Ophir

    2011-01-01

    Models that explain the economical and political realities of nowadays societies should help all the world's citizens. Yet, the last four years showed that the current models are missing. Here we develop a dynamical society-deciders model showing that the long lasting economical stress can be solved when increasing fairness in nations. fairness is computed for each nation using indicators from economy and politics. Rather than austerity versus spending, the dynamical model suggests that solving crises in western societies is possible with regulations that reduce the stability of the deciders, while shifting wealth in the direction of the people. This shall increase the dynamics among socio-economic classes, further increasing fairness.

  16. Information society studies

    CERN Document Server

    Duff, Alistair S

    2013-01-01

    We are often told that we are ""living in an information society"" or that we are ""information workers."" But what exactly do these claims mean, and how might they be verified? In this important methodological study, Alistair S. Duff cuts through the rhetoric to get to the bottom of the ""information society thesis."" Wide-ranging in coverage, this study will be of interest to scholars in information science, communication and media studies and social theory. It is a key text for the newly-unified specialism of information society studies, and an indispensable guide to the future of this disc

  17. Julie Lazes, Conflictualité, distribution et instabilité macroéconomique. Comportements rentiers et modes de régulation en Argentine

    Directory of Open Access Journals (Sweden)

    Julie Lazes

    2012-05-01

    Full Text Available À partir des travaux de Simmel sur la socialisation par le conflit, la thèse cherche à préciser la nature des compromis institutionnalisés en Argentine, en mettant en évidence la possibilité d’une reproduction économique fondée sur la violence. Cette violence s’incarne dans la présence d’une dynamique comportementale de type rentière c’est-à-dire s’articulant autour de la recherche d’une émancipation de la contrainte sociale, économique et politique. Bien que cette caractéristique soit inhérente au capitalisme, elle prend une dimension importante dans une société reposant sur une forte concentration des richesses et notamment de la propriété foncière.From a sociological approach to conflicting relationships as a process of social creation of links based on G. Simmel’s work, the main focus of this PhD dissertation is on the nature of institutionalized compromise in Argentina and a possible economic reproduction based on violence. We carry out the conclusion that in Argentina, violence is embodied into the rentier’s behavioral dynamics. In this case, violence is articulated with the pursuit of emancipation of the social, economic and political constraint. Even though this feature is inherent to capitalism, it takes an important dimension in a society that has been founded on a high concentration of wealth and, most particularly, in the concentration of land ownership.

  18. North American Menopause Society

    Science.gov (United States)

    ... Advertisements NAMS in the News Press Room Assistance Society Overview Top 10 reasons why NAMS is your ... fully updated and referenced 5th edition of the Society’s leading professional resource, featuring the latest comprehensive clinical ...

  19. National Multiple Sclerosis Society

    Science.gov (United States)

    ... Join the Community Stay Informed Corporate Support National Multiple Sclerosis Society Our Mission: People affected by MS can ... 10.5 Million in New Research to Stop Multiple Sclerosis, Restore Function and End MS Forever October 11, ...

  20. Valie EXPORT Society Rooseumis

    Index Scriptorium Estoniae

    2002-01-01

    Malmös Rooseumi Kaasaegse Kunsti Keskuses näitus "Baltic Babel". Projekt koosneb Läänemeremaade linnades tegutsevate innovatiivsete gruppide aktsioonidest. Kuraator Charles Esche. Esinejatest (Eestist Valie Export Society: Kadi Estland, Killu Sukmit)

  1. Changing anthropology, changing society.

    Science.gov (United States)

    Varughese, Heather

    2009-12-01

    Fifty years after the founding of the field of medical anthropology, the Society for Medical Anthropology of the American Anthropological Association held its first independent meeting on September 24-27, 2009, at Yale University.

  2. Valie EXPORT Society. Overlok

    Index Scriptorium Estoniae

    2001-01-01

    Valie EXPORT Society asutasid 23. okt. 1999. a. Frankfurdis Kadi Estland, Killu Sukmit ja Mari Laanemets, kui olid külastanud austria naiskunstniku Valie Exporti näitust. Rühmituse aktsioonide kirjeldus

  3. Society of Gynecologic Surgeons

    Science.gov (United States)

    ... December 1 – 3, 2016. This year’s course includes didactic lectures by outstanding surgeons and educators who are ... held in high esteem by other medical societies. Education Evidence-Based Medicine article published in OBG Mangement ...

  4. Pediatric Endocrinology Nurses Society

    Science.gov (United States)

    ... International Welcome to PENS The Pediatric Endocrinology Nursing Society (PENS) is committed to the development and advancement of nurses in the art and science of pediatric endocrinology nursing. Learn More ...

  5. American Society of Nephrology

    Science.gov (United States)

    ... join the conversation today. Learn More The American Society of Nephrology (ASN) leads the fight against kidney diseases by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care ...

  6. The Tranquebarian Society

    DEFF Research Database (Denmark)

    Jensen, Niklas Thode

    2015-01-01

    of this development was the establishment of the Tranquebarian Society, the third learned society east of the Cape of Good Hope. The article examines the unique assemblage of scientific networks, people, instruments, institutions, and ideas of local and global origin that converged in Tranquebar, and it investigates...... the fusion of local problems and radical ideas of enlightenment, education, and improvement that united government, mission, and merchants in Tranquebar in the quest for ‘useful knowledge’....

  7. Consumption in the Information Society

    Science.gov (United States)

    Zherebin, V. M.; Ermakova, N. A.; Makhrova, O. N.

    2010-01-01

    The current state of the economy in the developed countries make it possible to characterize them using concepts and terms such as the postindustrial society, the new economy, the service economy, the creative economy, the posteconomic society, the information society, the knowledge society, and the consumer society. Among these terms and…

  8. Nuclear technology and society

    International Nuclear Information System (INIS)

    This special issue of Journal of the Atomic Energy Society of Japan deals with the relation between nuclear technology and society, and is composed of four papers: (1) Nuclear energy and international politics - sociotechnics around plutonium utilization; (2) Risk recognition and benefit recognition of nuclear facilities and social acceptance; (3) Environmental risk management and radioactive waste problem; and, (4) Public administration around the relation between nuclear energy and society. (1) describes the historical development of nuclear energy since its birth, focusing on how the leading countries tried to control nuclear proliferation. Peaceful utilization of nuclear energy is closely connected with the Non-proliferation problem. (1) also discusses the relation of plutonium utilization of Japan with international society. (2) discusses how nuclear facilities can be accepted by society, analyzing the background of risk recognition, in particular, of psychological character of mass society. (3) introduces an new approach (risk-based or risk-informed regulation) of environmental risk management for radioactive waste disposal problem, focusing on HLW (high-level waste). (4) explains the approach from public administration to nuclear energy and general energy policy and introduces PPA (participatory policy analysis) as a means for policy making. (M.M.)

  9. Perpetuating Social Movements amid Declining Opportunity: The Survival Strategies of Two Argentine Piquetero Groups

    Directory of Open Access Journals (Sweden)

    Edward C. Epstein

    2009-04-01

    Full Text Available This article examines the recent behaviour in Argentina of two national protest groups of socalled ‘piqueteros’ or picketers (impoverished unemployed individuals who used the blockage of strategic roads and bridges to force government concessions that emerged politically in the buildup to the crisis of 2001-2002. Using theoretical concepts developed by McAdam, Tarrow, and Tilly in understanding social movements, the author analyses what he calls the ‘survival strategy’ adopted by their leaders as the political opportunities that produced their initial growth gave way to a more hostile environment with the normalization of Argentine politics under the Kirchner administration. While the two piquetero groups studied differ considerably in terms of their politics and ideology, both ended up depending on the same traditional tactic of utilizing important government contacts to obtain the resources necessary for organizational maintenance, despite their nominal identity as radical protesters against the present political system.Resumen: Perpetuando movimientos sociales y oportunidades decrecientes: las estrategias de sobrevivencia de dos grupos de piqueteros argentinesEste artículo examina el comportamiento reciente de dos grupos nacionales de protesta argentinos llamados ‘piqueteros’ (desempleados empobrecidos que usaron el bloqueo de calles y puentes estratégicos para forzar concesiones gubernamentales que aparecieron durante la crisis de 2001- 2002. Utilizando conceptos teóricos creados por McAdam, Tarrow, y Tilly en su discusión sobre los movimientos sociales, el autor analiza lo que describe como ‘estrategias de sobrevivencia’ adoptadas por sus dirigentes cuando las oportunidades que ocasionaron su crecimiento inicial cedieron ante un ambiente más hostil en el contexto de la normalización de la política argentina durante la administración de Kirchner. Aunque los dos grupos piqueteros estudiados se diferencian mucho en t

  10. An independent test of thermal subsidence and asthenosphere flow beneath the Argentine Basin

    Science.gov (United States)

    Hohertz, Warren L.; Carlson, Richard L.

    1998-09-01

    We have used primary precision depth recorder and single channel seismic data from three cruises of the R/V Conrad to test thermal subsidence and asthenosphere flow models for seafloor depth versus age in the Argentine Basin in the western South Atlantic. We found a region in the west central part of the basin where anomalously shallow depths, that can not be explained by any simple thermal or dynamic model, are associated with a local free-air gravity anomaly. Elsewhere, over ages ranging from 1 to 104 Ma, there is no evidence of the "flattening" of the depth/age trend that is characteristic of the plate cooling model for the thermal subsidence of the oceanic lithosphere. The halfspace thermal subsidence model accounts for nearly 98% of the variance of seafloor depth, but the slope, b=425±10 m Ma -1/2, implies improbably high mantle temperatures and/or low mantle densities. Moreover, there is some systematic misfit between the data and the halfspace model. A thermal subsidence model in which initial conditions vary with age accounts for the misfit, but also requires an implausible variation of mantle temperature and/or density. Alternatively, a model that includes the effect of induced flow in the asthenosphere eliminates the misfit and yields a reasonable rate of thermal subsidence b=330±20 m Ma -1/2. That the mantle temperature ( Tm˜1150±70)°C implied by the subsidence rate is slightly lower than normal is consistent with the hypothesis that this region has not been affected by hot spots or mantle plumes. The viscosity of the asthenosphere derived from the model (3-4 × 10 19 Pa s) is high, but consistent with viscosities estimated from plate dynamics models when the low mantle temperature is taken into account. Finally, the PMS flow model is consistent with measured heat flow in the region. These results lend weight to the hypothesis that the bathymetry of the Argentine Basin is influenced by induced flow in the asthenosphere, as well as by halfspace

  11. Chemical quality of different argentine honey varieties, irradiated to control american foulbrood

    International Nuclear Information System (INIS)

    'American foulbrood' is a disease that seriously affects bees. Honey may be contaminated with spores of the related bacteria, Paenibacillus larvae larvae, which is a great drawback for trade. The scientific literature reports that these spores, resistant to heat and chemicals, are inactivated in honey when it is irradiated al 10 kGy, being this treatment mandatory in the Republic of Southafrica. Irradiated food wholesomeness is endorsed by the World Health Organization. Considering that Argentina is an important honey producer and exporter, the aim of this work was to evaluate the effect of ionizing radiation on some of its commercial chemical parameters along storage time. Honeys with different characteristics, coming from five different regions of the country: Middle, Patagonia, North, Litoral, Humid Pampa, were provided by producers from a commission called 'Packaged honey' of the National Food, Fishery and Agriculture Ministry. Fifteen kg of each honey variety were packaged in 500 g polypropylene recipes with polyethylene lids, and irradiated at the semi industrial cobalt-60 facility of the Ezeiza Atomic Center, 500,000 Ci of activity, with doses of 0, 10 and 20 kilo Grays. Control and irradiated samples were stored at room temperature for 10 months. Some standardized chemical analysis required by the Argentine Food Code (AFC) were performed on the first, fourth and tenth storage months: water content, acidity, diastase content, reducing sugars, and hydroxymethylfurfural. Reducing sugars and diastase activity slightly diminished, and acidity slightly increased, along storage which is typical in this product; no significant differences were found between control and irradiated samples. Hydroxymethylfurfural values, related to aging or thermal abuse, diminished slightly though significantly due to irradiation, which would not affect the product quality as regulations require not to surpass a maximum value, 40 mg/kg in the AFC. So ionizing

  12. The rat acute-phase protein {alpha}{sub 2}-macroglobulin plays a central role in amifostine-mediated radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Mirjana, Mihailovic; Goran, Poznanovic; Nevena, Grdovic; Melita, Vidakovic; Svetlana, Dinic; Ilijana, Grigorov; Desanka, Bogojevic, E-mail: mista@ibiss.bg.ac.r [Department of Molecular Biology, Institute for Biological Research ' Sinisa Stankovic' , University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade (Serbia)

    2010-09-15

    Previously we reported that elevated circulating concentrations of the acute-phase (AP) protein {alpha}{sub 2}-macroglobulin ({alpha}{sub 2}M), either as typically occurring in pregnant female rats or after administration to male rats, provides radioprotection, displayed as 100% survival of experimental animals exposed to total-body irradiation with 6.7 Gy (LD{sub 50/30}) x-rays, that is as effective as that afforded by the synthetic radioprotector amifostine. The finding that amifostine administration induces a 45-fold increase in {alpha}{sub 2}M in the circulation led us to hypothesise that {alpha}{sub 2}M assumes an essential role in both natural and amifostine-mediated radioprotection in the rat. In the present work we examined the activation of cytoprotective mechanisms in rat hepatocytes after the exogenous administration of {alpha}{sub 2}M and amifostine. Our results showed that the IL6/JAK/STAT3 hepatoprotective signal pathway, described in a variety of liver-injury models, upregulated the {alpha}{sub 2}M gene in amifostine-pretreated animals. In both {alpha}{sub 2}M- and amifostine-pretreated rats we observed the activation of the Akt signalling pathways that mediate cellular survival. At the cellular level this was reflected as a significant reduction of irradiation-induced DNA damage that allowed for the rapid and complete restoration of liver mass and ultimately at the level of the whole organism the complete restoration of body weight. We conclude that the selective upregulation of {alpha}{sub 2}M plays a central role in amifostine-provided radioprotection.

  13. Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling

    Energy Technology Data Exchange (ETDEWEB)

    Nakayama, Fumiaki, E-mail: f_naka@nirs.go.jp [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, Chiba (Japan); Umeda, Sachiko [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, Chiba (Japan); Yasuda, Takeshi [Radiation Emergency Medicine Research Program, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan); Fujita, Mayumi [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, Chiba (Japan); Asada, Masahiro [Signaling Molecules Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba (Japan); Meineke, Viktor [Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich (Germany); Imamura, Toru [Signaling Molecules Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba (Japan); Imai, Takashi [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, Chiba (Japan)

    2014-02-01

    Purpose: Several fibroblast growth factors (FGFs) were shown to inhibit radiation-induced tissue damage through FGF receptor (FGFR) signaling; however, this signaling was also found to be involved in the pathogenesis of several malignant tumors. In contrast, FGF12 cannot activate any FGFRs. Instead, FGF12 can be internalized readily into cells using 2 cell-penetrating peptide domains (CPP-M, CPP-C). Therefore, this study focused on clarifying the role of FGF12 internalization in protection against radiation-induced intestinal injury. Methods and Materials: Each FGF or peptide was administered intraperitoneally to BALB/c mice in the absence of heparin 24 hours before or after total body irradiation with γ rays at 9 to 12 Gy. Several radioprotective effects were examined in the jejunum. Results: Administration of FGF12 after radiation exposure was as effective as pretreatment in significantly promoting intestinal regeneration, proliferation of crypt cells, and epithelial differentiation. Two domains, comprising amino acid residues 80 to 109 and 140 to 169 of FGF12B, were identified as being responsible for the radioprotective activity, so that deletion of both domains from FGF12B resulted in a reduction in activity. Interestingly, these regions included the CPP-M and CPP-C domains, respectively; however, CPP-C by itself did not show an antiapoptotic effect. In addition, FGF1, prototypic FGF, possesses a domain corresponding to CPP-M, whereas it lacks CPP-C, so the fusion of FGF1 with CPP-C (FGF1/CPP-C) enhanced cellular internalization and increased radioprotective activity. However, FGF1/CPP-C reduced in vitro mitogenic activity through FGFRs compared with FGF1, implying that FGFR signaling might not be essential for promoting the radioprotective effect of FGF1/CPP-C. In addition, internalized FGF12 suppressed the activation of p38α after irradiation, resulting in reduced radiation-induced apoptosis. Conclusions: These findings indicate that FGF12 can protect the

  14. Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling

    International Nuclear Information System (INIS)

    Purpose: Several fibroblast growth factors (FGFs) were shown to inhibit radiation-induced tissue damage through FGF receptor (FGFR) signaling; however, this signaling was also found to be involved in the pathogenesis of several malignant tumors. In contrast, FGF12 cannot activate any FGFRs. Instead, FGF12 can be internalized readily into cells using 2 cell-penetrating peptide domains (CPP-M, CPP-C). Therefore, this study focused on clarifying the role of FGF12 internalization in protection against radiation-induced intestinal injury. Methods and Materials: Each FGF or peptide was administered intraperitoneally to BALB/c mice in the absence of heparin 24 hours before or after total body irradiation with γ rays at 9 to 12 Gy. Several radioprotective effects were examined in the jejunum. Results: Administration of FGF12 after radiation exposure was as effective as pretreatment in significantly promoting intestinal regeneration, proliferation of crypt cells, and epithelial differentiation. Two domains, comprising amino acid residues 80 to 109 and 140 to 169 of FGF12B, were identified as being responsible for the radioprotective activity, so that deletion of both domains from FGF12B resulted in a reduction in activity. Interestingly, these regions included the CPP-M and CPP-C domains, respectively; however, CPP-C by itself did not show an antiapoptotic effect. In addition, FGF1, prototypic FGF, possesses a domain corresponding to CPP-M, whereas it lacks CPP-C, so the fusion of FGF1 with CPP-C (FGF1/CPP-C) enhanced cellular internalization and increased radioprotective activity. However, FGF1/CPP-C reduced in vitro mitogenic activity through FGFRs compared with FGF1, implying that FGFR signaling might not be essential for promoting the radioprotective effect of FGF1/CPP-C. In addition, internalized FGF12 suppressed the activation of p38α after irradiation, resulting in reduced radiation-induced apoptosis. Conclusions: These findings indicate that FGF12 can protect the

  15. Radioprotection in dentistry: Analyze of the universities of Dentistry of the State of Rio de Janeiro concerning personal

    International Nuclear Information System (INIS)

    This work shows the need and the importance training and graduating odontologists on radioprotection has. This is based on the recent proposal made by Technical Regulations: Trends for Radiological Protection in Medical and odontologists Radiodiagnosis issued by the Secretariat of Health Security from the Ministry of Health. These establish basic standards for radiation protection in medical and odontological areas and include principles; limits, duties and basic controls to protect human beings and the environment against possible individual effects derived from the use of ionizing radiation sources

  16. Radioprotective role of H{sub 2}S/CSE pathway in Chang liver cells

    Energy Technology Data Exchange (ETDEWEB)

    Pan Yan; Ye Shuang; Yuan Dexiao; Zhang Jianghong; Bai Yang [Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032 (China); Shao Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032 (China); Division of Nuclear Medicine, School of Medical Sciences, Anhui Medical University, Hefei (China)

    2012-10-15

    Radiation-induced liver cell damage may be life-threatening. Here, we investigated whether hydrogen sulfide (H{sub 2}S)/cystathionine {gamma}-lyase (CSE) pathway could serve the protective role toward radiation in normal human liver cells. Our data showed that pretreatment of cells with H{sub 2}S donor, sodium hydrosulfide (NaHS) significantly attenuated radiation induced micronuclei formation and improved cell viability. However, the use of DL-propargylglycine (PPG), a potent inhibitor of CSE, markedly enhanced the cell-killing effect induced by radiation. Exposure of cells to 2 Gy {gamma}-radiation led to significant increases of the endogenous H{sub 2}S content. The mRNA and protein expressions of CSE also increased after radiation in a time-dependent manner, while the expression of cystathionine {beta}-synthase (CBS), another endogenous H{sub 2}S synthetase, did not change significantly. Notably, radiation induced production of reactive oxygen species (ROS) was significantly reversed by the pretreatment of NaHS, while blockage of CSE activity resulted in an enhanced ROS production in irradiated cells. Moreover, NaHS markedly suppressed radiation-induced phosphorylation of P53, decrease of Bcl-2/Bax, and activity of nuclear factor kappaB (NF-{kappa}B). In conclusion, our finding demonstrates that H{sub 2}S/CSE pathway plays a radioprotection role by inhibiting radiation-induced ROS production, P53 phosphorylation, NF-{kappa}B activation and decrease of Bcl-2/Bax, indicating that modulation of H{sub 2}S may be a novel protection strategy for liver radiation injury in radiotherapy.

  17. Radioprotective effect of rhizome extract of Zingiber montanum in Rattus norvegicus.

    Science.gov (United States)

    Thokchom, D S; Sharma, T D; Sharma, G J

    2012-08-01

    The present study aims at determining the ability of 60% ethanol extract of the rhizome of Zingiber montanum (J. König) A. Dietr. to protect bone marrow cells in vivo from radiation-induced chromosomal aberrations. Albino rats (Rattus norvegicus, 2n = 42) were used to carry out investigations on the radioprotective properties of Z. montanum. Acute toxicity of the extract was determined, and a suitable injectable dose was selected for intra-peritoneal administration. The LD(50) of the extract calculated for 72 h was 2.9 g/kg, and the calculated LD(10) dose was 1.7 g/kg. The calculated maximum tolerated dose of the rhizome extract was 1.3 g/kg. Rats were divided into 12 groups (with or without the administration of extract) and exposed to different radiation doses from 1 to 5 Gy. Whole-body irradiation of rats showed a significant dose-dependent increase in different types of chromosomal aberrations. The most common chromosomal aberrations were breaks, fragments, gaps, rings, endoreduplications and dicentric chromosomes. Ethanol extract of rhizome at a dose of 0.5 g/kg did not show any significant increase in chromosomal aberrations in unirradiated animals as compared to that of the control group. Intra-peritoneal administration of the extract at a dose of 0.5 g/kg considerably reduced the frequency of the aberrations stated above in irradiated animals with DMF value of 1.36 at 1 to 5 Gy dose range of gamma radiation. The incidence of micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes due to the radiation exposure was considerably reduced in extract-treated groups of animals with DMFs 1.34 and 1.17, respectively, as compared to that of the extract-untreated groups. Our results suggest that rhizome extract of Z. montanum may have a potential in protecting normal hematopoietic cells from radiation-induced damage. PMID:22678694

  18. The binding of the radioprotective agent cysteamine with the phospholipidic membrane headgroup-interface region

    International Nuclear Information System (INIS)

    The interaction of the aminothiol radioprotector cysteamine (β-mercaptoethylamine)(CYST) with dipalmitoylphosphatidylcholine (DPPC) artificial membranes has been studied by differential scanning calorimetry (DSC), turbidimetry and spin labeling. This hydrophilic molecule displays a biphasic, concentration-dependent binding to the phospholipidic head groups at neutral pH. In the CYST/DPPC molar ratio 1:160-1:2 (mole/mole) an increasing ordering effect is observed. At high concentrations (over 3:1 ratio), this ordering effect decreases. With the symmetric disulfide dimer cystamine, the biphasic effect is not shown and the membrane rigidity decrease is obtained only at concentration ratio higher than 1:1. The charge repartition of the cysteamine molecule has been shown to be disymmetric, +0.52 e on the NH3 group and +0.19 e on the SH extremity, whereas the cystamine molecule is electrostatically symmetrical. These properties could be related to their membrane effects. With cysteamine, at a low concentration, an electrostatic bridging between the negatively charged phosphate groups of the polar heads induces the increase in membrane stability: the molecules behave like a divalent cation. At high concentration a displacement of the slightly charged SH extremity by the amine disrupts the bridges and induces the decrease in rigidity: the drug behaves like a monovalent cation. Due to its symmetric charge and its double length, such an effect is not observed with cystamine. This study could bring further information about the interactions between cysteamine and polyelectrolytic structures (ADN for example) and about the radioprotective properties of this drug. (author)

  19. Radioprotective potency of ginseng on some haematopoietic and physiological parameters in irradiated rats

    International Nuclear Information System (INIS)

    Currently, investigations focus on co administration of natural products with radiation treatment. The present study was assessed to investigate the potency of ginseng as a radioprotective agent on haematopoietic cell recovery, the content of reduced glutathione (GSH) and malonaldehyde (MDA) level in addition to physiological bio markers. Panax ginseng was intraperitoneally injected (100 mg/ kg) to female rats 24 h before gamma irradiation of 7 Gy which is liable to disturb the haematopoietic system and the organs involved as the bone marrow and spleen. Animals were investigated after 5 and 9 days from irradiation, ginseng or dual treatments. Irradiation caused significant wt loss of the body and spleen, decrease in bone marrow (B.M.) viable cells, significant depression in leukocytes with its differential counts, significant drop in erythrocytes, haemoglobin and haematocrite values besides elevation in MCV. Gamma-irradiation treatment resulted in significant increase in serum MDA and glucose as well as significant reduction in blood GSH. Significant elevations in transaminases (ALT and AST) and alkaline phosphatase (ALP) activities were recorded after gamma irradiation. Preservation of body wt, B.M. viable cells, spleen wt and haematopoietic cell recovery was evident upon ginseng pre-administration. It ameliorated the depression in GSH content and the elevation in MDA level. ALT, AST and ALP were depressed approaching the control level after 9 days from dual treatments and blood sugar level was maintained. The study points out the promising positive role played by ginseng as a nontoxic natural product to reduce the time necessary for reconstituting haematopoietic cells and protecting vital physiological processes after irradiation

  20. Radioprotective potential of Emblica officinalis fruit extract against hematological alterations induced by gamma radiation

    International Nuclear Information System (INIS)

    In the era of expending nuclear energy program all over the world, the role of radiation biology has acquired greater relevance and significance in addressing the health issues in view of constant human exposure to various types of radiations. Radioprotective drugs hold immense promise for saving precious human lives in from irradiation in various situations. Currently available synthetic radiomudulators is fraught with their inherent toxicity at the optimum dose and hence the need to discover and develop new more effective less toxic radiomudulatory drugs from natural sources. In the present study, the protective effect of Emblica officinalis fruit extract (EOFE) has been assessed by estimating hematological constituents against irradiation. For this purpose, Swiss albino mice were divided into four groups. Group I was administered with double distilled water (DDW) volume equal to EOFE (100 mg./kg. body wt./animal/clay) by oral gavages to serve as normal. Group II was administered orally EOFE for 7 days once daily at a does of 100 mg./kg.b. wt./animal/day, Group Ill animals were exposed to 2.5 Gy gamma radiations to serve as irradiated control. Group IV mice were treated with EOFE, orally for consecutive days (as in Group II) and were exposed to 2.5 Gy gamma rays half an hr. after the last administration of EOFE on day 7th. The above animals were necropsied on 12 hr, 24 hr, 3 days, 5 days, 10 days, 20 days and 30 days post treatment intervals, and their blood was collected for estimation of blood constituents. A significant decline in RBC, hemoglobin (Hb) and hematocrit (Hct) contents from normal was observed in irradiated control animals (Group III). All these parameters were found to be significantly higher in EOFE pretreated irradiated animals (Group IV). From these results, it is concluded that Emblica officinalis fruit extract has the ability to protect the individuals from radiation-induced hematological injuries. (author)

  1. Radioprotective effects of flavonoids against to chromosomal damage: relation between the structure and activity

    Energy Technology Data Exchange (ETDEWEB)

    Alcaraz, M.; Acevedo, C.; Benavente-Garcia, O.; Castillo, J.; Vicente, V.; Canteras, M.

    2004-07-01

    Protective effects of grape (Vitis vinifera) seed (GSE), Citrus spp. fruits (CE) and olive Olea europaea L) leaf (OL) extracts, the flavonoids diosmin and rutin, widely used as pharmaceuticals, and diemthyl sulphoxide (DMSO) against chromosomal damage induced by X-rays and g radiation were determined by using two different micronucleus test for anti genotoxic activity. The quantitative distribution of several flavones-3-ols was determined using HPLC in a grape (Vitis vinifera), seed extract (GSE) and Olea european (OL) of four cultivars grown in the region of Murcia. Polymer>C4 units made up the largest group of procyanidins in the GSE (90,92%, expressed as HPLC% area). The antioxidant activity of GSE and other reference compounds was investigated by measuring theirs ability to scavenge the ABTS+ radical cation (TEAC). The most effective compounds were in order: GSE >rutin>(+)-catechin>OL>diosmina>ascorbic acid. The radioprotective effects of GSE and other reference compounds were determined by using the micronucleus test for anticlastogenic activity, any reduction of the frequency of micronucleated polychromatic erythrocytes (mnOCEs) being evaluated in the bone marrow of mouse exposed to X rays; and evaluating the reduction in the frequency of micronuclei in citokinesis-blocked cells of human lymphocytes exposed to g-rays. The most effective compounds were, in order: GSE>rutin>dimetylsufoxide (DMSO)>ascorbic acid>OL>6-n-propyl-2-thiouracil-6c (PTU)>disomin. The higher ABTS scavenging capacity and antigenotoxic activity of GSE can be explained, structurally, by the high number of conjugated structures between the catechol groups in the B-rings ant the 3-OH free groups of the polymeric polyphenolic skeleton and, in addition, by the stability of the aroxyl flavonoide radical generated in the above processes. (Author)

  2. Bystander effects of the ionizing radiation and his implications in radiotherapy and radioprotection

    International Nuclear Information System (INIS)

    According to the classical paradigm, biological effects of ionizing radiation are attributed to DNA damage induced in each irradiated cell. Demonstration of ionizing radiation-induced bystander effects (RIBE) has generated a deep change in current understanding of radiobiology. RIBE are radiation-induced effects produced in cells that have not been actually irradiated. Several technical advances, particularly the use of microbeams, allowed in vitro study of RIBE. There are two known ways by which irradiated cells can communicate with non-irradiated cells, namely: through gap junctions connecting the cytoplasms of adjacent cells, and through the secretion of soluble factors to the extracellular medium. These factors include several cytokines and reactive species of oxygen and nitrogen. In the affected cells, signalling pathways mostly involve activation of mitogen-activated protein kinases (MAPK), NF-kB transcription factor and of the enzymes cyclooxygenase 2, nitric oxide synthase 2 and NAD (P)H oxidase. RIBE induce point mutations and epigenetic changes. Effects on cellular signalling pathways can persist indefinitely and even be transmitted to the progeny of affected cells. Paradoxically, under certain conditions RIBE may be adaptive, which means that they turn affected cells more resistant to ionizing radiation. Adaptation demands protein synthesis. It enhances DNA repair mechanisms and resistance to oxidative stress. RIBE have also been demonstrated in vivo. Thus, they may have important implications for radiotherapy, both to improve therapeutic efficacy and to reduce the incidence of adverse effects. Furthermore, a better understanding of RIBE may have an influence on international radioprotection standards. (authors)

  3. Panorama of the industrial gammagraphy in Argentina, regulatory experience in radioprotection matter

    International Nuclear Information System (INIS)

    It is of general knowledge the high factor of incidence at world level of radiological accidents due to the practices of industrial gamma radiography. Such factors as the one constant movement of radioactive sources of significant activity and the work pressures to which are subjected the operators appear as the primordial causes of accidental situations. The purpose of this work is to present the main aspects of the Argentinean regulation as regards radiological safety to control this practice and by this way to contribute to reduce the associated risks. With the purpose of achieving this objective, it is carried out a review of the regulatory activities carried out in the last years in the Argentine Republic with the intention of verifying the effective execution of the normative one. On the other hand to the effects of presenting the situation in our country of this technique of non destructive essays, such aspects as the number of companies that possess in use operation licenses at the present time to operate equipment of gamma radiography and the geographical distribution of the same ones are described, as well as the number of in use individual permits is detailed. Likewise an histogram that includes an estimate of the maximum and average dose received by the whole of those operators with reason of such practice during the last years is presented. In the same way, an equipment distribution and discriminated containers against by trademark is show. By the other hand some incidents happened in Argentina during the last years are described, the causes that drove to these events and its relationship with the nonfulfillment to the in use normative are mentioned, as well as its consequences and the adopted measures to remedy them. Lastly, the importance of the training and the training in the promotion of a strong safety culture, key element in all starting work is emphasized. (Author)

  4. Les intellectuels espagnols exilés dans l'Argentine peroniste

    Directory of Open Access Journals (Sweden)

    Laurent Bonardi

    2008-12-01

    Full Text Available El gobierno argentino del general Perón reveló ser un verdadero chaleco salvavidas para la dictadura española. Esta política de cooperación provoca una viva oposición en Argentina. Este trabajo propone un análisis de las reacciones de los intelectuales españoles exiliados en Argentina. Observaremos de que manera los intelectuales españoles lucharon contra la dictadura franquista durante el idilio hispano-argentino y analizaremos el “modus operandi” adoptado por el gobierno peronista para obstaculizar las actividades anti-franquistas en el exilio.__________________ABSTRACT:The Argentine government of general Perón becomes an authentic life jacket for the Spanish dictatorship. This policy of cooperation triggers ample dispproval in Argentina. We propose an analysis of the reactions of the spanish intellectuals exiled in Argentina. We will see how the Spanish intellectuals fight against the Franco dictatorship during the honeymoon Hispanic-Argentinean. Also we will analyze the modus operandi adopted by the Peronist government to prevent the antifrancoist activities of the exiliados.

  5. Lithologic identification and characterization using ETM+ (Landsat 7. Study case of the Upsala glacier basin, Argentine

    Directory of Open Access Journals (Sweden)

    A. Lo Vecchio

    2016-06-01

    Full Text Available The object of this study aims to evaluate and analyze digital image processing techniques applied to the Enhanced Thematic Mapper Plus (ETM+, in order to demark and characterize the outcropping lithologies on the Upsala Glacier basin, Santa Cruz, Argentine Republic. The prolific technological and spatial development experienced in the last decades has given place to the generation, without precedents, of multiple remote sensors capable of capturing information of the terrestrial surface and also the improvement of digital image processing techniques and software; amongst them, the amazing possibilities in the detection and differentiation of diverse covers present on the terrestrial surface can be highlighted, such as glaciers, volcanoes, vegetation, soils, water, types of rock outcrops, etc. This situation improves mapping and monitoring of natural phenomenon in the Earth Sciences field. The proposed methodology includes radiometric corrections, elimination of unwanted covers, statistical evaluation in the combination of the most appropriate bands, application of the Z index, discretization of the statistical series, entailing tasks of spectral classification with field samples and a later validation. Valuable results were obtained by means of digital processing of images, that were validated yielding a 82% of accuracy in the proposed classification, which are good results taking into account the diversity of covers present and the lithological heterogeneity that makes up each pixel (30m. These results were also validated with existing geological maps, obtaining a good agreement.

  6. Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF).

    Science.gov (United States)

    Sundblad, Victoria; Chiauzzi, Violeta A; Escobar, Maria Eugenia; Dain, Liliana; Charreau, Eduardo H

    2004-07-30

    Diverse mutations in FSH-receptor (FSHR) gene have been described as possible cause of premature ovarian failure (POF). To investigate the presence of mutations and/or polymorphisms in FSHR gene, DNA from 20 POF, 5 of which were diagnosed as resistant ovary syndrome (ROS), and from 44 controls was isolated from peripheral lymphocytes. The complete coding sequence was analysed by PCR followed by SSCP, direct sequencing or restriction enzyme analysis. No mutations in FSHR gene were identified in the patients studied. The two already described polymorphisms in exon 10, A919G and A2039G, cosegregated in all the homozygous individuals, indicating that FSHR presents two isoforms: Ala307-Ser680 and Thr307-Asn680. OR results suggest that the 919G-2039G allelic variant or the homozygous genotype is not associated to disease risk. In addition, a heterozygous substitution T1022C (Val341Ala) was found in two control subjects. We suggest that mutations in FSHR gene are rare in women with POF in Argentine. Presence of a particular FSHR isoform does not appear to be associated with this disease.

  7. Training and the personnel accreditation of regulatory functions in the Argentine Republic

    International Nuclear Information System (INIS)

    Teaching and the training are indispensable for the development of the human resources in all disciplines and occupations of the man in the world scale. About the applications of the radionuclides in the nuclear industry, in Argentina, during the last years, the efforts have been intensified. The necessity of improving the capacity of answer in radiation protection and nuclear safety demands an focus integrated in the teaching and the training. The radiological protection and the nuclear safety presents elements of the applied physics, the chemistry, the biology, the nuclear technology and other specialized subjects. However, in relation with the development of the human resources, specially those that belong to regulatory bodies and perform inspection functions, have important differences, necessities and specific problems. Some differences and problems emerge of the wide diversity and reach of the radiological and nuclear applications. Nowadays, in the world, the applications of the radiation and radioactive sources are being diversified in the medicine (diagnosis, radiotherapy, nuclear medicine, the industry, the agricultures, and the investigation and teaching), that involve a permanent knowledge and actualization of the personnel of the regulatory bodies. For that exposed this work describe training program for the personnel with regulatory functions (inspectors) of the Nuclear Regulatory Authority in the Argentine Republic. Also, this document includes the description of the basic formation and specialized in each case and it reach. (author)

  8. Reflections on the development of local suppliers for the Argentine nuclear industry

    International Nuclear Information System (INIS)

    Argentina has given recently a new start to its nuclear power activities. Looking for background and experiences that can be useful under the new reality, the paper is a survey of the past development of local suppliers for the national nuclear industry. Based on the intention to answer the questions: Why so early it was decided to build a nuclear power plant? Why it was decided to buy it under a turnkey basis rather than developing an indigenous design? and what was the meaning of the 'opening of the technology package' at that time?, the paper describes the actions that led to the purchase of the Atucha I, Embalse and Atucha II nuclear power plants and how these decisions were implemented in order to maximize local participation and the technology transfer. It also analyzes the influence of the Argentine Nuclear Plan of the late seventies on the development of endogenous technology and describes the facts that helped to preserve until now the technological nuclear capabilities of the country in spite of the stopping of the Atucha II construction, and to create positive expectations regarding the revival of the local industry as a supplier of nuclear goods and services. (author)

  9. Myxozoans as biological tags for stock identification of the Argentine hake, Merluccius hubbsi (Gadiformes: Merlucciidae).

    Science.gov (United States)

    Cantatore, D M P; Irigoitia, M M; Holzer, A S; Timi, J T

    2016-05-01

    Myxozoans have been successfully used as tags for fish stock identification around the world. However, few studies using myxozoan tags have been carried out in the Southern Atlantic, a region with complex oceanography that constitutes a potentially suitable scenario for testing the utility of myxozoans as indicators. Its usefulness was tested using six samples of Merluccius hubbsi in two different regions of the Argentine Sea. Generalized linear models were performed to assess the effects of fish size and sex, and year and region of capture and selected using the Information Theoretic approach. Three myxozoan species were recorded: Kudoa rosenbuschi, Myxoproteus meridionalis and Fabespora sp. Results of modelling species individually showed differential capabilities for detecting geographical population structure at different spatial scales, with K. rosenbuschi and Fabespora sp. allowing the discrimination of northern and southern stocks, but Fabespora sp. also as a promissory indicator of intrapopulation sub-structure due to different migratory routes during non-reproductive periods. This work confirms that myxozoans offer a set of suitable markers at different spatial scales, which can be selected individually or in any combination, depending on the geographical extent of the study, constituting tools adaptable to the objectives of further research on fish population structure.

  10. Characterization of pectinase activity for enology from yeasts occurring in Argentine Bonarda grape

    Directory of Open Access Journals (Sweden)

    María Gabriela Merín

    2015-09-01

    Full Text Available Pectinolytic enzymes are greatly important in winemaking due to their ability to degrade pectic polymers from grape, contributing to enhance process efficiency and wine quality. This study aimed to analyze the occurrence of pectinolytic yeasts during spontaneous fermentation of Argentine Bonarda grape, to select yeasts that produce extracellular pectinases and to characterize their pectinolytic activity under wine-like conditions. Isolated yeasts were grouped using PCR-DGGE and identified by partial sequencing of 26S rRNA gene. Isolates comprised 7 genera, with Aureobasidium pullulans as the most predominant pectinolytic species, followed by Rhodotorula dairenensis and Cryptococcus saitoi. No pectinolytic activity was detected among ascomycetous yeasts isolated on grapes and during fermentation, suggesting a low occurrence of pectinolytic yeast species in wine fermentation ecosystem. This is the first study reporting R. dairenensis and Cr. saitoi species with pectinolytic activity. R. dairenensis GM-15 produced pectinases that proved to be highly active at grape pH, at 12 °C, and under ethanol and SO2 concentrations usually found in vinifications (pectinase activity around 1.1 U/mL. This strain also produced cellulase activity at 12 °C and pH 3.5, but did not produce β-glucosidase activity under these conditions. The strain showed encouraging enological properties for its potential use in low-temperature winemaking.

  11. Characterization of pectinase activity for enology from yeasts occurring in Argentine Bonarda grape.

    Science.gov (United States)

    Merín, María Gabriela; Martín, María Carolina; Rantsiou, Kalliopi; Cocolin, Luca; de Ambrosini, Vilma Inés Morata

    2015-01-01

    Pectinolytic enzymes are greatly important in winemaking due to their ability to degrade pectic polymers from grape, contributing to enhance process efficiency and wine quality. This study aimed to analyze the occurrence of pectinolytic yeasts during spontaneous fermentation of Argentine Bonarda grape, to select yeasts that produce extracellular pectinases and to characterize their pectinolytic activity under wine-like conditions. Isolated yeasts were grouped using PCR-DGGE and identified by partial sequencing of 26S rRNA gene. Isolates comprised 7 genera, with Aureobasidium pullulans as the most predominant pectinolytic species, followed by Rhodotorula dairenensis and Cryptococcus saitoi. No pectinolytic activity was detected among ascomycetous yeasts isolated on grapes and during fermentation, suggesting a low occurrence of pectinolytic yeast species in wine fermentation ecosystem. This is the first study reporting R. dairenensis and Cr. saitoi species with pectinolytic activity. R. dairenensis GM-15 produced pectinases that proved to be highly active at grape pH, at 12 °C, and under ethanol and SO2 concentrations usually found in vinifications (pectinase activity around 1.1 U/mL). This strain also produced cellulase activity at 12 °C and pH 3.5, but did not produce β-glucosidase activity under these conditions. The strain showed encouraging enological properties for its potential use in low-temperature winemaking. PMID:26413065

  12. Urban Infestation Patterns of Argentine Ants, Linepithema humile, in Los Angeles

    Directory of Open Access Journals (Sweden)

    Smadar Gilboa

    2012-01-01

    Full Text Available Infestations of buildings by Argentine ants, Linepithema humile (Mayr, were monitored on the campus of the University of California, Los Angeles. Foraging ant activity peaked during the hotter months of the year. The mean monthly maximum temperature, but not rainfall, positively correlated with indoor infestation frequency. Neither garden size nor the predominant groundcover vegetation correlated with the number of foraging ants at baits within gardens. Although the number of foraging ants outside a building varied over 40-fold, ant density in gardens did not predict the likelihood of infestation within the building. Also, the type of vegetative groundcover employed did not predict infestation frequency. There was, however, a significant negative relationship between the size of the garden outside of a building and the number of infestations. Given the large foraging area of L. humile workers, buildings next to small gardens may be infested simply because they lie within the “normal” foraging area of a colony. The best predictor of which rooms were infested within buildings was the presence of a water source. Thus providing water for ant colonies outside and away from buildings may be one method of integrated pest management to reduce the proclivity of ants to infest structures.

  13. Argentine activities related to the development of low enriched fuel elements

    International Nuclear Information System (INIS)

    Within the framework of the RERTR Program and supported by the technical cooperation work agreed upon between the USA and Argentina in May 1979, the CNEA Nuclear Fuel Department - Low Enriched Fuel Elements Project (ECBE Project) has carried on its own program for developing fuels with low enrichment for research and test reactors. Up to the present, its main objective has been to replace the highly enriched fuel used in its only reactor (RA-3) for research, development and radioisotopes production. The basic stages of the Argentine Program are shown. The densities reached were within the range of 3.12 to 3.58 g/cm3 for U3O8-Al, 2.99 to 3.09 g/cm3 for UAl2-Al and 5.18 to 6.10 g/cm3 for U3Si-Al. If further miniplates can be irradiated, it is the purpose of the program to research uranium densities of 3.5 g/cm3 in UAl2-Al and 6.5 g/cm3 in U3Si-Al

  14. Magnetic and Moessbauer Studies of Quaternary Argentine Loessic Soils and Paleosols

    Energy Technology Data Exchange (ETDEWEB)

    Mercader, R. C., E-mail: mercader@fisica.unlp.edu.ar; Sives, F. R. [Universidad Nacional de La Plata, Departamento de Fisica, IFLP, Facultad de Ciencias Exactas (Argentina); Imbellone, P. A. [Universidad Nacional de La Plata, Instituto de Geomorfologia y Suelos (Argentina); Vandenberghe, R. E. [Ghent University, NUMAT, Department of Subatomic and Radiation Physics (Belgium)

    2005-02-15

    This paper is a review of the current status about the remaining problems that are found in the investigation of the Quaternary Argentine soils and loessic sediments, and the way that Moessbauer studies can assist in solving them. There are two main types of investigations that make use of the magnetic response of the samples to correlate them with information gathered by other methods. On the one hand, there is the stratigraphic and chronological research, which is of importance from the geological and paleontological points of view. On the other hand, the paleoclimatic records, of significance toward a possible model of the past climate, are also studied because of their close relation to the sediments history. However, there is not yet a model that can tell the difference between the modifications due to the climatic conditions at the time when the soils were buried from processes that occurred after burial. Some examples are given that show that Moessbauer studies can be applied with a certain degree of success when cross-checked with magnetic measurements toward understanding the processes that occurred in alluvial B (paleosols) and C horizons (loess) from the eastern part of Buenos Aires Province. Although the application of Moessbauer studies to hydromorphic processes in soils is not straightforward, there are cases in which Moessbauer spectroscopy, if applied properly and correlated with other techniques, is able to characterize the type of iron oxides existing in the materials and thus assist theories about its origin and history.

  15. Chemical defense by the native winter ant (Prenolepis imparis against the invasive Argentine ant (Linepithema humile.

    Directory of Open Access Journals (Sweden)

    Trevor R Sorrells

    Full Text Available The invasive Argentine ant (Linepithema humile is established worldwide and displaces native ant species. In northern California, however, the native winter ant (Prenolepis imparis persists in invaded areas. We found that in aggressive interactions between the two species, P. imparis employs a potent defensive secretion. Field observations were conducted at P. imparis nest sites both in the presence and absence of L. humile. These observations suggested and laboratory assays confirmed that P. imparis workers are more likely to secrete when outnumbered by L. humile. Workers of P. imparis were also more likely to secrete near their nest entrances than when foraging on trees. One-on-one laboratory trials showed that the P. imparis secretion is highly lethal to L. humile, causing 79% mortality. The nonpolar fraction of the secretion was chemically analyzed with gas chromatography/mass spectrometry, and found to be composed of long-chain and cyclic hydrocarbons. Chemical analysis of dissected P. imparis workers showed that the nonpolar fraction is derived from the Dufour's gland. Based on these conclusions, we hypothesize that this chemical defense may help P. imparis to resist displacement by L. humile.

  16. Civil society sphericules

    DEFF Research Database (Denmark)

    Tufte, Thomas

    2014-01-01

    the organization strategizes about and seeks to articulate amongst Tanzanian youth. Situated in the ‘perverse confluence’ (Dagnino, 2011) between neoliberal and radical democratic agendas in the communicative practices of civil society-driven media platforms, Femina navigates between identities as an NGO, a social...... movement and a media initiative. In the context of the growing literature on social networking sites and their affordances, dynamics and structures, the case of Femina illustrates how a civil society sphericule emerges within the dynamic co-evolution of new and old media platforms. The study is furthermore...... an example of the difficult shift in civil society practice, from service provision to an agenda of public service monitoring, social accountability and community engagement....

  17. Science and Society Colloquium

    CERN Multimedia

    Randi, J

    1991-01-01

    Mr. Randi will give an update of his lecture to the American Physical Society on the occasion of his award of the 1989 Forum Prize. The citation said: "for his unique defense of Science and the scientific method in many disciplines, including physics, against pseudoscience, frauds and charlatans. His use of scientific techniques has contributed to refuting suspicious and fraudulent claims of paranormal results. He has contributed significantly to public understanding of important issues where science and society interact". He is a professional magician and author of many books. He worked with John Maddox, the Editor of Nature to investigate the claims of "water with memory".

  18. The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L

    International Nuclear Information System (INIS)

    The radioprotective effects of Noni juice on the bone marrow of irradiated Mus musculus L. (7-week old IRC strain) was studied using the micronucleus test. Five mice were used for each of the six groups; negative and positive control, 25%, 50%, 75%, 100% treatment. Both negative and positive control groups were not treated with Noni juice. However, the negative control was not irradiated. Four different concentrations, a mixture of distilled water and commercial Noni juice, were administered via oral gavage to mice in their specific groups during the 15-day feeding schedule. A day (24H) after the last treatment, the mice were irradiated (6 Gy of gamma radiation). Two days (48H) after irradiation, the mice were sacrifice and the femur were extracted. The bone marrow cells were collected and slides were prepared. One thousand polychromatic erythrocytes (PCE) were screened for the presence of micronucleus per mouse. The mean frequency of micronucleated PCE were as follows: negative control, 15; positive control, 45; 25% treatment, 21; 50% treatment, 18; 75% treatment, 11; 100% treatment, 7. The Kruskal-Wallis test showed that the groups' responses varied (α=0.05). Multiple comparison showed that there were significant differences between: (1) 25% and 100% treatment group; (2) positive control group and 75% treatment group; (3) positive control group and 100% treatment group, thus indicating that Noni juice is effective in inhibiting micronucleus formation at high concentrations. The result also showed that radioprotective potential of Noni juice follows a dose-dependent pattern. (Author)

  19. Evaluation of radioprotective efficacy of pyrimidine-5- carboxylate derivative on electron beam induced oxidative stress using Drosophila Melanogaster

    International Nuclear Information System (INIS)

    Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. Several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. Chemicals capable of scavenging free radicals, inducing oxygen depletion, ant ioxidants and modulators of immune response have been some of the radioprotectors extensively investigated with limited success. In the present study the radioprotective efficacy of Ethyl 4-(4-(benzyloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate on electron beam induced oxidative stress was evaluated using Drosophila melanogaster (Oregon K). Initially the molecule was tested for in vitro antioxidant activity and it showed moderate DPPH radical scavenging activity and good hydroxyl radical scavenging activity compared to standard glutathione. Hence, this compound was screened for its radioprotective activity. The compound was supplied to flies in the form of diet. The electron beam irradiated flies were assayed for oxidative stress markers name Thiobarbituric acid reactive substances (TBARS), enzymatic and Non-enzymatic antioxidants. The pyrimidinone showed modulator effect on the oxidative stress markers caused by e-beam radiation. (author)

  20. Studies on in vivo radioprotection efficacy of indazolone derivative on electron beam induced oxidative stress using Drosophila Melanogaster

    International Nuclear Information System (INIS)

    Indazole nucleus is an effective pharmacophore in medicinal chemistry and shows diverse biological and pharmacological activities. Indazolone and its derivatives show a wide spectrum of pharmacological activities as some of them act as dopamine antagonists, anti-inflammatory, analgesic and antipyretic agents. Benzyl-1H-indazole-3-carboxilic acids has antispermatogenetic and anticancer activity. In the present study the synthesis of 4-(4-methoxyphenyl)-6-phenyl-1,2,4,5-tetrahydro-3H-indazol-3-one was carried out and characterized by spectral and analytical data. The synthesized indazolone derivative showed good in vitro antioxidant activity namely, DPPH radical scavenging assay, FRAP assay etc. By keeping the antioxidant property in mind the synthesized molecule was screened for its in vivo radioprotection activity using Drosophila Melanogaster (Oregon K). The compound was supplied to flies in the form of diet and the safety evaluation was carried out for 7 days at 300 μg/ml concentration. Later the electron beam irradiated flies were assayed for oxidative stress markers namely, Thiobarbituric acid reactive substances (TBARS), enzymatic and Non enzymatic antioxidants.The results showed that the indazolone molecule exhibited good in vivo radioprotection activity. (author)

  1. Radioprotective properties of Cumaside, a complex of triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol.

    Science.gov (United States)

    Aminin, Dmitry L; Zaporozhets, Tatiana S; Adryjashchenko, Pelageya V; Avilov, Sergey A; Kalinin, Vladimir I; Stonik, Valentin A

    2011-05-01

    The radioprotective activity has been studied of a new immunomodulatory lead material, Cumaside, which is a complex of monosulfated triterpene glycosides from the edible sea cucumber Cucumaria japonica and cholesterol. Female CD-1 strain mice administered with prophylactic doses of Cumaside were irradiated using a Gamma-therapeutic device with a 60Co source (exposure dose 6.5 Gy, dose rate 1.14 Gy/min) and the average life span of the mice was determined. The animals administrated with Cumaside and irradiated were killed by pervisceral dislocation on days 4 and 9. Peripheral blood cell composition indexes, blood forming function and cell number in blood-forming organs and the number of pluripotent blood-forming stem cells were determined using standard procedures and the results compared with those of non-treated irradiated mice. The survivability percentage and average life span of the irradiated mice that were not treated with Cumaside were decreased in comparison with the Cumaside-treated groups. Especially, the leukocyte and neutrophil numbers in the blood (bone marrow from hip), and the weight and cell number of lymphoid organs were higher in the Cumaside-treated groups compared with the non-treated irradiated mice. It was concluded that at low prophylactic doses Cumaside possesses moderate radioprotective properties. PMID:21615013

  2. The radioprotective efficacy of the rat acute-phase protein alpha2-macroglobulin on bone marrow cells

    Directory of Open Access Journals (Sweden)

    Mihailović Mirjana

    2009-01-01

    Full Text Available The rat acute phase protein α2-macroglobulin (α2M plays an important role in the restoration of disrupted homeostasis by inhibiting different types of non-specific proteases and facilitating the transport of cytokines, growth factors and hormones. Previously, we observed that administration of α2M to experimental animals prior to the infliction of life- threatening trauma in the form of scalding or total-body irradiation, significantly improved their survival rates. The aim of the present work was to evaluate the radioprotective effect on blood cells of α2M that, when administered 30 min before irradiation with 6.7 Gy (LD50/30, provides 100% survival of experimental animals where in unprotected irradiated rats the said dose results in 50% lethality. We observed that rats pretreated with α2M, after an initial decline, exhibited complete recovery of the leukocyte count due to the preservation of bone marrow cells, observed as a stable mitotic index. In untreated irradiated rats the decrease of the mitotic index reflected the significant destruction of bone marrow cells that resulted in a protracted decline in the leukocyte count. We conclude that the radioprotection provided by α2M was in part mediated through cytoprotection of new blood cells produced in the bone marrow.

  3. Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

    Energy Technology Data Exchange (ETDEWEB)

    Rezende Barbosa, Gabriella Lopes de; Almeida, Solange Maria de, E-mail: gabriellalopes@live.com [Universidade de Campinas (UNICAMP), Piracicaba, SP (Brazil). Escola de Odontologia. Departmento de Diagnostico Oral; Pimenta, Luiz Andre [University of North Carolina at Chapel Hill, School of Dentistry, Department of Dental Ecology, Chapel Hill, NC (United States)

    2016-05-01

    The purpose of this study was to perform a micro computerized tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a micro computerized tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey's post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues. (author)

  4. Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue

    Directory of Open Access Journals (Sweden)

    Abolhasan Rezaeyan

    2016-01-01

    Full Text Available This study was carried out to evaluate radioprotective effects of hesperidin (HES administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage. Fifty-eight rats were divided into four groups: Group 1 received phosphate buffered saline (PBS and sham radiation; Group 2, HES and sham radiation; Group 3, PBS and radiation; and Group 4, HES and radiation. The rats were exposed to single dose of 18 Gy of 6 MV X-ray. One hundred milligrams per kilogram doses of HES was administered for 7 days before irradiation. The estimation of superoxide dismutase (SOD, malondialdehyde (MDA, and histopathological analyses was performed at 24 h and 8 weeks after radiation exposure. The irradiation of chest area resulted in an elevated MDA level and decreased SOD activity. Moreover, long-term pathological lesions of radiation were inflammation, fibrosis, the increased number of mast cells and macrophages, and development of plaque, vascular leakage, myocardial degeneration, and myocyte necrosis. Although the administration of HES decreases inflammation, fibrosis, mast cell and macrophage numbers, and myocyte necrosis, it did not result in reduced thrombus, myocardium degeneration, and vascular leakage. In conclusion, these results suggest that HES can perform a radioprotection action. The protective effect of HES may be attributable to its immunomodulatory effects and free radical-scavenging properties.

  5. Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes

    International Nuclear Information System (INIS)

    Sesamol pretreated (1, 5 and 10 μg/ml) lymphocytes were exposed to different doses of γ-radiation, i.e., 1, 2 and 4 Gray (Gy) and the cellular changes were estimated by using cytokinesis blocked micronucleus assay (MN), dicentric aberration (DC), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Radiation significantly increased MN, DC frequencies, TBARS levels and decreased GSH and antioxidant enzyme levels in a dose dependent manner. The highest damage to lymphocytes was observed at 4 Gy irradiation. On the other hand, sesamol pretreatment significantly decreased MN, DC frequencies, TBARS levels and increased GSH levels and SOD, CAT and GPx activities in a concentration dependent manner. At 1 Gy irradiation all concentrations of sesamol (1, 5 and 10 μg/ml) significantly protects the lymphocytes from radiation damage. At 2 Gy irradiation 5 and 10 μg/ml of sesamol shows significant radioprotection. Since the highest damage was observed at 4 Gy irradiation both 1 and 5 μg/ml of sesamol pretreatment were not sufficient to protect the lymphocytes from radiation damage but 10 μg/ml of sesamol significantly (p < 0.05) protects the lymphocytes from radiation effect. Thus, sesamol pretreatment gives significant protection to cultured human lymphocytes against γ-radiation induced cellular damage. The possible mechanism involved in the radioprotective influence of sesamol is discussed

  6. Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue.

    Science.gov (United States)

    Rezaeyan, Abolhasan; Haddadi, Gholam Hassan; Hosseinzadeh, Massood; Moradi, Maryam; Najafi, Masoud

    2016-01-01

    This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage. Fifty-eight rats were divided into four groups: Group 1 received phosphate buffered saline (PBS) and sham radiation; Group 2, HES and sham radiation; Group 3, PBS and radiation; and Group 4, HES and radiation. The rats were exposed to single dose of 18 Gy of 6 MV X-ray. One hundred milligrams per kilogram doses of HES was administered for 7 days before irradiation. The estimation of superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological analyses was performed at 24 h and 8 weeks after radiation exposure. The irradiation of chest area resulted in an elevated MDA level and decreased SOD activity. Moreover, long-term pathological lesions of radiation were inflammation, fibrosis, the increased number of mast cells and macrophages, and development of plaque, vascular leakage, myocardial degeneration, and myocyte necrosis. Although the administration of HES decreases inflammation, fibrosis, mast cell and macrophage numbers, and myocyte necrosis, it did not result in reduced thrombus, myocardium degeneration, and vascular leakage. In conclusion, these results suggest that HES can perform a radioprotection action. The protective effect of HES may be attributable to its immunomodulatory effects and free radical-scavenging properties. PMID:27651565

  7. Radioprotective effect of local administration of lysine-vasopressin and triglycyl-lysine-vasopressin on the rectal mucosa in rats

    Energy Technology Data Exchange (ETDEWEB)

    Bjelkengren, G. [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden); Aronsen, K.F. [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden); Augustsson, N.E. [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden); Borgstroem, S. [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden); Lindstroem [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden); Nylander, G. [Depts. of Experimental Medicine, Oncology and Pathology, MalmoeUniv. Hospital (Sweden)

    1995-12-31

    Reactions from the rectal mucosa often give rise to troublesome side-effects during and after radiotherapy in the pelvic region. Local vasoconsriction in the rectal mucosa will cause an ischemia which will decrease the sensitivity of the mucosal cells to radiation and thereby these side-effects can be reduced. Triglycyl-lysine-vasopressin applied rectally in 1% Blanose solution gave in the present study significant radioprotection of the rectal mucosa in the doses of 0.8, 1.6, and 3.2 mg. These doses are, however, very high. Triglycyl-lysine-vasopressin in 1.2% Natrosol solution in a dose of 128 {mu}g did not show any certain protective effects. However lysine-vasopressin in 1.2% Natrosol solution in a dose of 16 {mu}g gave significant radioprotection of the rectal mucosa. This dose level has in a previous study not given any significant effects on the systemic circulation. Lysine-vasopressin in Natrosol solution seems to be a suitable combination for further studies. (orig.).

  8. Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

    Directory of Open Access Journals (Sweden)

    Gabriella Lopes DE REZENDE BARBOSA

    2016-01-01

    Full Text Available Abstract The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey’s post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05. The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues.

  9. Science, technology and society

    CERN Document Server

    Giacomelli, G

    2005-01-01

    We shall discuss some aspects of science and technology, their increasing role in the society, the fast advances in modern science, the apparent decrease of interest of the young generation in basic sciences, the importance of proper science popularization for better public education and awareness in scientific fields.

  10. Italian Society of Physics

    International Nuclear Information System (INIS)

    The abstracts of most of the papers read at the 53 National Congress of the Italian Society of Physics are presented. The Congress developed in ten sessions: high energy and elementary particle physics, physics of nuclei, condensed matter, quantum electronics, cosmic physics, geophysics, general physics, electronics and applied physics, health physics and hystory of physics. An author index is also included

  11. MARX EMBRYOLOGY OF SOCIETY

    NARCIS (Netherlands)

    WOUTERS, A

    1993-01-01

    This article presents a new interpretation of Marx's dialectical method. Marx conceived dialectics as a method for constructing a model of society. The way this model is developed is analogous to the way organisms develop according to the German embryologist Karl Ernst von Baer, and, indeed, Marx's

  12. Connecting Science with Society

    DEFF Research Database (Denmark)

    awareness of the important questions of our society reflected in scientific research and of the answers produced by these research activities. The CRIS2010 conference, entitled “Bringing Science to Society”, therefore seeks to highlight the role of Current Research Information Systems for communicating...

  13. Exploratory of society

    Science.gov (United States)

    Cederman, L.-E.; Conte, R.; Helbing, D.; Nowak, A.; Schweitzer, F.; Vespignani, A.

    2012-11-01

    A huge flow of quantitative social, demographic and behavioral data is becoming available that traces the activities and interactions of individuals, social patterns, transportation infrastructures and travel fluxes. This has caused, together with innovative computational techniques and methods for modeling social actions in hybrid (natural and artificial) societies, a qualitative change in the ways we model socio-technical systems. For the first time, society can be studied in a comprehensive fashion that addresses social and behavioral complexity. In other words we are in the position to envision the development of large data and computational cyber infrastructure defining an exploratory of society that provides quantitative anticipatory, explanatory and scenario analysis capabilities ranging from emerging infectious disease to conflict and crime surges. The goal of the exploratory of society is to provide the basic infrastructure embedding the framework of tools and knowledge needed for the design of forecast/anticipatory/crisis management approaches to socio technical systems, supporting future decision making procedures by accelerating the scientific cycle that goes from data generation to predictions.

  14. Multiethnic Societies and Regions.

    Science.gov (United States)

    Stanfield, John H., II

    1996-01-01

    Maintains that sociology must reconceptualize the meaning of multiethnic societies and regions and also advance theories about how such social organizations came into being and transform themselves through conflicting and peaceful processes. Briefly reviews traditional approaches and outlines new areas of study. (MJP)

  15. Radioprotection of bone marrow stem cell subsets by interleukin-1 and kit-ligand : Implications for CFU-S as the responsible target cell population

    NARCIS (Netherlands)

    van Os, Ronald; Lamont, G; Witsell, A; Mauch, PM

    1997-01-01

    Various cytokines have been reported to have radioprotective effects on the bone marrow. Of these, c-kit-ligand (KL) and interleukin-1 (IL-1) have the most dramatic effect when given prior to total body irradiation (TBI). Given simultaneously, KL and IL-1 demonstrated a strong effect on increasing t

  16. Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro.

    Science.gov (United States)

    Cinkilic, Nilufer; Tüzün, Ece; Çetintaş, Sibel Kahraman; Vatan, Özgür; Yılmaz, Dilek; Çavaş, Tolga; Tunç, Sema; Özkan, Lütfi; Bilaloğlu, Rahmi

    2014-08-01

    The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes with cinnamic acid prior to irradiation reduced the number of micronuclei when compared with that in control samples. Treatment with cinnamic acid without irradiation did not increase the number of micronuclei and did not show a cytostatic effect in the lymphocytes. The results of the alkaline comet assay revealed that cinnamic acid reduces the DNA damage induced by X-rays, showing a significant radio-protective effect. Cinnamic acid decreased the frequency of irradiation-induced micronuclei by 16-55% and reduced DNA breakage by 17-50%, as determined by the alkaline comet assay. Cinnamic acid may thus act as a radio-protective compound, and future studies may focus on elucidating the mechanism by which cinnamic acid offers radioprotection.

  17. Transport Limits for Non-Fixed Contamination: A Hazard to Optimization in Radioprotection

    Energy Technology Data Exchange (ETDEWEB)

    Theis, S.; Lorenz, B.; Schwarz, W.

    2004-07-01

    members from regulatory bodies, expert groups, research and industry. Considering a nuclide specific approach and even reduced dose constraints, as a result higher contamination values could be acceptable for nearly all radionuclides. Although the new exposure model and the calculation of derived personal exposure have been formulated in consensus of the working group, it is still unclear, if and how these results will influence the IAEA revision process and the regulatory practice in the individual countries. A proposal is given, how the results of the new modeling can be implemented in the IAEA TS-R-1. Many working hours of nuclear personnel could be devoted to topics with a significantly higher benefit for radioprotection. (Author)

  18. Appraisal of radio-protective potential of Tinospora cordifolia against radiation mediated biochemical alterations in intestine

    International Nuclear Information System (INIS)

    per oxidation level through out the period of study which suggests that it has a role in protection against radiation-induced membrane and cellular damage. Thus, the results from the present study demonstrate a radioprotective effect of the T.cordifolia root extract from radiation-induced biochemical alterations in intestine of mammals. (author)

  19. Evaluation of free radical scavenging and radioprotective efficacy of Aloe vera extract

    International Nuclear Information System (INIS)

    Radiation induced damage and lethality to the normal tissues can be partially reduced by the use of radio-protectors that lower down the damaging effects of radiation. In the present study radio-protective effect of Aloe vera extract which is rich in vitamins. It is basically cellular regenerator and therefore acts, with very positive results in many conditions. It is reported to have antioxidant, anti carcinogenic, antimicrobial and immunity stimulants properties. For the present experiment, healthy Swiss albino mice (6-8 weeks old) were selected and maintained under standard conditions of temperature and light. Aloe vera juice was fed orally at the dose rate of 0.01 m1/animal/day. The animals were divided into seven groups according to the treatment given to them i.e. given cadmium chloride solution as drinking water (group-II) or exposed to 5.0 Gy gamma radiations (group-III) or combined treatment of radiation and cadmium chloride (group-IV). The alterations in the biochemical parameters of all these group were compared with that of sham irradiated animals (group-I). The animals of experimental groups were given Aloe vera seven days prior to radiation or cadmium chloride treatment (group-V, VI and VII) respectively. All biochemical parameters of the control groups were compared with the respective experimental groups. An increase in the value of total proteins, glycogen, acid and alkaline phosphatase activity and RNA was observed up to day-14 in the non drug treated group and day-7 in the Aloe vera groups. Thereafter value declined up to day-28 without reaching to the normal. Whereas the value of cholesterol and DNA showed a decreasing trend up to day-14 in non drug treated groups and day-7 in Aloe vera treated groups. Thus it showed that cadmium and radiation produced toxic effect on kidney and Aloe vera minimize these effects. Protection offered by Aloe vera may be due to the scavenging or oxidizing free radicals. Thus it can be concluded that Aloe vera may

  20. 15 June 2009 - President of the Argentine Nation C. Fernández visiting ATLAS experimental area.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Tirage 1:President of the Argentine Nation, C. Fernández and Minister of Science, Technology and Innovative Production,L. Barañao Tirage 2-8:Arrival greetings Tirage 9-12:Introduction to CERN's activities by Director-General, R. Heuer Tirage 13-15:Signature of the guest book Tirage 16-25:M. Benedetti,R. Heuer and L.Barañao sit for the signature of the Agreement Tirage 26-33: Meeting with Argentinian scientists at CERN

  1. La construction territoriale de têtes de ponts antarctiques rivales : Ushuaia (Argentine) et Punta Arenas (Chili)

    OpenAIRE

    Guyot, Sylvain

    2012-01-01

    Ushuaia et Punta Arenas sont les villes les plus australes de leurs pays d’appartenance,  l’Argentine et le Chili. Elles ont joué le rôle de ville frontière au service de la consolidation et la légitimation de ces territoires nationaux austraux localisés en position de bout du monde. Depuis cinquante ans, ces deux villes portuaires s’affirment comme les deux portes d’entrée internationales principales des relations avec le continent Antarctique, et en particulier avec la Péninsule Antarctique...

  2. Figurations of Islandness in Argentine Culture and Literature: Macedonio Fernández, Leopoldo Marechal, and César Aira

    Directory of Open Access Journals (Sweden)

    Norman Cheadle

    2009-11-01

    Full Text Available This article explores islandness in the River Plate imaginary. Two modern foundational “island texts” – Thomas More’s Utopia and Daniel Defoe’s Robinson Crusoe – have exerted a formative influence on the Spanish-American colonial imagination, an influence inflected by the particular historical experience of the River Plate region and its dominant city, Buenos Aires. The figuration of islandness is examined in three twentieth-century Argentine novels by Macedonio Fernández, Leopoldo Marechal, and César Aira. The article finds both continuity and evolution in the images of islandness in these novels.

  3. Suspending the next turn as a form of repair initiation: evidence from Argentine Sign Language.

    Science.gov (United States)

    Manrique, Elizabeth; Enfield, N J

    2015-01-01

    Practices of other-initiated repair deal with problems of hearing or understanding what another person has said in the fast-moving turn-by-turn flow of conversation. As such, other-initiated repair plays a fundamental role in the maintenance of intersubjectivity in social interaction. This study finds and analyses a special type of other-initiated repair that is used in turn-by-turn conversation in a sign language: Argentine Sign Language (Lengua de Señas Argentina or LSA). We describe a type of response termed a "freeze-look," which occurs when a person has just been asked a direct question: instead of answering the question in the next turn position, the person holds still while looking directly at the questioner. In these cases it is clear that the person is aware of having just been addressed and is not otherwise accounting for their delay in responding (e.g., by displaying a "thinking" face or hesitation, etc.). We find that this behavior functions as a way for an addressee to initiate repair by the person who asked the question. The "freeze-look" results in the questioner "re-doing" their action of asking a question, for example by repeating or rephrasing it. Thus, we argue that the "freeze-look" is a practice for other-initiation of repair. In addition, we argue that it is an "off-record" practice, thus contrasting with known on-record practices such as saying "Huh?" or equivalents. The findings aim to contribute to research on human understanding in everyday turn-by-turn conversation by looking at an understudied sign language, with possible implications for our understanding of visual bodily communication in spoken languages as well. PMID:26441710

  4. Suspending the next turn as a form of repair initiation: evidence from Argentine Sign Language

    Directory of Open Access Journals (Sweden)

    Elizabeth eManrique

    2015-09-01

    Full Text Available Practices of other-initiated repair deal with problems of hearing or understanding what another person has said in the fast-moving turn-by-turn flow of conversation. As such, other-initiated repair plays a fundamental role in the maintenance of intersubjectivity in social interaction. This study finds and analyses a special type of other-initiated repair that is used in turn-by-turn conversation in a sign language: Argentine Sign Language (Lengua de Señas Argentina or LSA. We describe a type of response termed a ‘freeze-look’, which occurs when a person has just been asked a direct question: instead of answering the question in the next turn position, the person holds still while looking directly at the questioner. In these cases it is clear that the person is aware of having just been addressed and is not otherwise accounting for their delay in responding (e.g., by displaying a ‘thinking’ face or hesitation, etc.. We find that this behavior functions as a way for an addressee to initiate repair by the person who asked the question. The ‘freeze-look’ results in the questioner ‘re-doing’ their action of asking a question, for example by repeating or rephrasing it. Thus we argue that the ‘freeze-look’ is a practice for other-initiation of repair. In addition, we argue that it is an ‘off-record’ practice, thus contrasting with known on-record practices such as saying ‘Huh?’ or equivalents. The findings aim to contribute to research on human understanding in everyday turn-by-turn conversation by looking at an understudied sign language, with possible implications for our understanding of visual bodily communication in spoken languages as well.

  5. The Utility of Seasonal Climate Forecasts: Understanding Argentine Farmers' Attribute Priorities and Trade-Offs

    Science.gov (United States)

    Seipt, E. C.; Easterling, W. E.

    2007-05-01

    A distinct El Niño - Southern Oscillation (ENSO) signal and its impacts have been confirmed in the Argentine Pampas, and precipitation variability is currently recognized as the region's most marked ENSO-driven influence. In the Pampas, precipitation is also a major limiting factor for agricultural production given spatial differences in soil water storage capacities and the region's relatively minimal use of irrigation. Seasonal climate forecasts that provide advanced knowledge of expected ENSO-driven precipitation anomalies may benefit farm management decision-making by helping to either mitigate potentially negative consequences or to take advantage of potentially positive influences. To be useful and applicable, however, these forecasts must suit the decisions that they are meant to inform. In this research, a case study is presented that investigates how farmers in the Pampas prioritize and trade off specific attributes of a seasonal climate forecast (i.e., mode of distribution, spatial resolution, lead time, and forecast performance) when judging its utility. A conjoint analysis evaluation decomposes holistic evaluations of forecasts into the part-worth utilities associated with their different attributes. Part-worth utilities combine to reveal the structure of farmers' forecast utility preferences - a model of the decision-making process. Utility preference structures are analyzed to compute the importance value of each attribute and to determine the trade-offs that farmers find acceptable between different attributes. Analysis indicates that, on average, spatial resolution is the most influential attribute in determining climate forecast utility. Attribute trade-off values suggest that advances in spatial resolution, forecast performance, and/or product dissemination via the Internet offer the greatest potential for increasing the utility of future seasonal climate forecasts for farmers in the Pampas.

  6. Ordovician K-bentonites in the Argentine Precordillera: relations to Gondwana margin evolution

    Science.gov (United States)

    Huff, W.D.; Bergstrom, Stig M.; Kolata, Dennis R.; Cingolani, C.A.; Astini, R.A.

    1998-01-01

    This paper is included in the Special Publication entitled 'The proto- Andean margin of Gondwana', edited by R.J. Pankhurst and C.W. Rapela. Ordovician K-bentonites have now been recorded from >20 localities in the vicinity of the Argentine Precordillera. Most occur in the eastern thrust belts, in the San Juan Limestone and the overlying the Gualcamayo Formation, but a few ash beds are known also from the central thrust belts. The oldest occur in the middle Arenig I, victoriae lunatus graptolite (Oe. evae conodont) Zone, and the youngest in the middle Llanvirn P. elegans (P. suecicus) Zone. Mineralogical characteristics, typical of other Ordovician K-bentonites, include a matrix of illite/smectite mixed-layer clay and a typical felsic volcanic phenocryst assemblage: biotite, beta-form quartz, alkali and plagioclase feldspar, apatite, and zircon, with lesser amounts of hornblende, clinopyroxene, titanite and Fe-Ti oxides. The proportions of the mineral phases and variations in their crystal chemistry are commonly unique to individual (or small groups of) K-bentonite beds. Glass melt inclusions preserved in quartz are rhyolitic in composition. The sequence is unique in its abundance of K-bentonite beds, but a close association between the Precordillera and other Ordovician sedimentary basins cannot be established. The ash distribution is most consistent with palaeogeographical reconstructions in which early Ordovician drifting of the Precordillera occurred in proximity to one or more volcanic arcs, and with eventual collision along the Andean margin of Gondwana during the mid-Ordovician Ocloyic event of the Famatinian orogeny. The Puna-Famatina terrane northeast of the Precordillera might have served as the source of the K-bentonite ashes, possibly in concert with active arc magmatism on the Gondwana plate itself.

  7. Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

    Directory of Open Access Journals (Sweden)

    Nicola-Siri Leonardo

    2006-01-01

    Full Text Available Abstract Background The occurrence of variations in the spectrum of cardiovascular disease between different regions of the world and ethnic groups have been the subject of great interest. This study report the 24-h variation of myocardial infarction (MI occurrence in patients recruited from CCU located in Argentina and Uruguay. Methods A cohort of 1063 patients admitted to the CCU within 24 h of the onset of symptoms of an acute MI was examined. MI incidence along the day was computed in 1 h-intervals. Results A minimal MI incidence between 03:00 and 07:00 h and the occurrence of a first maximum between 08:00 and 12:00 h and a second maximum between 15:00 and 22:00 h were verified. The best fit curve was a 24 h cosinor (acrophase ~ 19:00 h, accounting for 63 % of variance together with a symmetrical gaussian bell (maximum at ~ 10:00 h, accounting for 37 % of variance. A similar picture was observed for MI frequencies among different excluding subgroups (older or younger than 70 years; with or without previous symptoms; diabetics or non diabetics; Q wave- or non-Q wave-type MI; anterior or inferior MI location. Proportion between cosinor and gaussian probabilities was maintained among most subgroups except for older patients who had more MI at the afternoon and patients with previous symptoms who were equally distributed among the morning and afternoon maxima. Conclusion The results support the existence of two maxima (at morning and afternoon hours in MI incidence in the Argentine and Uruguayan population.

  8. Scheme of 3 interfaces with local isostatic compensation on the Argentine continental margin

    Science.gov (United States)

    Pedraza De Marchi, A. C.; Ghidella, M. E.; Tocho, C.

    2013-05-01

    The segment of Argentine continental margin located between 39°S and the Malvinas platform (~49°S) is of passive type and volcanic characteristics revealed by seaward-dipping seismic reflectors sequences (SDRs). The free air gravity edge-effect associated with passive continental margins is one of the most distinctive characteristics of gravity in marine regions. This effect is in large part due to the transition between continental and oceanic crusts, because of their different thicknesses. In this presentation we investigate the Airy type isostatic compensation scheme by using three interfaces in a forward calculation with different approximations of Parker's expression to obtain the isostatic anomaly. After that we perform the inversion of the anomaly thus obtained in order to find the Moho's deflection necessary to compensate it (or minimize it) by using the same scheme of interfaces and the iterative Parker-Oldenburg method (Oldenburg, D., 1974) with more terms in the inversion. The crust-mantle interface (Moho) thus calculated represents a more realistic surface than the one calculated using one term in the inversion and the surface estimated with topographic data and sediment thickness. Even considering that the experiment constitutes a schematic assumption just to test the numerical methods involved, we find that in the comparison with the only available digitized refraction profile, the inverted Moho interface reproduces fairly well the Moho that the seismic profile yields, for the case of the iterative method. This suggests that the inverse calculation with the iterative method is sensible to the presence of the SDRS, at least for this sole profile. Keywords: isostatic anomaly, Moho, passive continental margins Oldenburg, D., 1974. The inversion and interpretation of gravity anomalíes, Geophysics, vol. 39, no. 4, p. 526-536.

  9. Geological Society of Africa

    Institute of Scientific and Technical Information of China (English)

    JohnD.Bennett; NasserEnnih; S.FelixToteu

    2005-01-01

    History and objectives,The ambitious and forward-looking decision to establish a pan-African geological society was taken during the course of a conference on African geology held in Ibadan, Nigeria in 1970. A Steering Committee was convened at that meeting under the Chairmanship of Professor Russell Black of the Department of Geology, Haile Selassie University, Addis Ababa, and the provisional constitution drafted by his Committee was approved at a second conference on African geology in Addis Ababa in 1973. Thus was the Geological Society of Africa (GSA.t) born. Its first President was Professor M O Owawoye (Nigeria) and Dr S M E1 Rabba (Sudan) became its first Secretary General.

  10. Branding Cities, Changing Societies

    DEFF Research Database (Denmark)

    Ooi, Can-Seng

    Societal changes are seldom discussed in the literature on city branding. The time element is important because it highlights the fluctuating reality of society. The city brand message freezes the place but in fact, the city branding exercise is a continuous process. Society emerges too. City...... brands are supposed to accentuate the uniqueness of the city, be built from the bottom-up and reflect the city's identity. This paper highlights three paradoxes, pointing out that city branding processes can also make cities more alike, bring about societal changes and forge new city identities. A city...... branding campaign does not just present the city, it may change the city. The relationships between the branding exercise and the city are intertwined in the evolution of the place....

  11. Transnationalising Civil Society?

    DEFF Research Database (Denmark)

    Jørgensen, Martin Bak

    The paper takes a transnational perspective on developing an analytical framework for understanding how transnationalism interacts with civil society and how immigrant organisations use transnational strategies to challenge the pre-given positions of immigrants within given integration- and citiz......The paper takes a transnational perspective on developing an analytical framework for understanding how transnationalism interacts with civil society and how immigrant organisations use transnational strategies to challenge the pre-given positions of immigrants within given integration...... degree, what kind of groups and which types of aims are pursued via these channels and this type of engagement. The paper ends with some preliminary empirical findings of transnational engagement and organisation among Alevis and (Turkish) Assyrians in Denmark, Sweden, and Germany....

  12. l'Internet Society

    CERN Multimedia

    CERN

    1997-01-01

    Conference of Vinton "Vint" Gray Cerf in the Intercontinental Hostel. Vinton Gray Cerf (born June 23, 1943) is an American computer scientist who is commonly referred to as one of the "founding fathers of the Internet" for his key technical and managerial role, together with Bob Kahn, in the creation of the Internet and the TCP/IP protocols which it uses. He was also a co-founder (in 1992) of the Internet Society (ISOC) which is intended to both promote the views of ordinary users of the Internet, and also serve as an umbrella body for the technical groups developing the Internet (such as the Internet Engineering Task Force). He served as the first president of the Internet Society from 1992-1995.

  13. Creativity In Conscience Society

    OpenAIRE

    Ion Gh. Rosca; Dumitru Todoroi

    2011-01-01

    Creativity is a result of brain activity which differentiates individuals and could ensure an important competitive advantage for persons, for companies, and for Society in general. Very innovative branches – like software industry, computer industry, car industry – consider creativity as the key of business success. Natural Intelligence Creativity can develop basic creative activities, but Artificial Intelligence Creativity, and, especially, Conscience Intelligence Creativity should be devel...

  14. Society and Social Power

    Directory of Open Access Journals (Sweden)

    Janani Harish

    2014-10-01

    Full Text Available Society is the source of immense power. Over the past few centuries humanity has record­ed phenomenal growth in its collective capacity for accomplishment, as reflected in the 12-fold growth in global per capita income since 1800. The remarkable achievements in living standards, longevity, science, technology, industry, education, democracy, human rights, peace and global governance are the result of the exponential development of the capacity of society to harness human energies and convert them into social power for productive purposes. Today, humanity possesses the power and capabilities needed to fully meet the multi-dimensional challenges confronting global society. The source of this energy is people. Human energy is transformed into social power by the increasing reach, frequency and complexity of human relationships. Society is a complex living network of organized relationships between people. Its power issues from channelizing our collective energies in productive ways by means of organizing principles such as coordination, systems, specialization of function, hierarchy of authority, and integration. This immense social power remains largely underutilized. Social science needs to evolve a comprehensive, trans-disciplinary understanding of the roots of social power and the process by which it is generated, distributed and applied. This knowledge is the essential foundation for formulating effective social policies capable of eradicating forever persistent poverty, unemployment and social inequality. This article is based on a series of lectures delivered by the author in the WAAS-WUC course on “Toward a Trans-disciplinary Science of Society” at Dubrovnik on September 1-3, 2014. It traces the development of social power in different fields to show that human and social capital are inexhaustible in potential. The more we harness them, the more they grow. Unleashing, directing, channeling and converting human potential into social

  15. Evolvement of Classification Society

    Institute of Scientific and Technical Information of China (English)

    Xu Hua

    2011-01-01

    As an independent industry, the emergence of the classification society was perhaps the demand of beneficial interests between shipowners, cargo owners and insurers at the earliest time. Today, as an indispensable link of the international maritime industry, class role has changed fundamentally. Start off from the demand of the insurersSeaborne trade, transport and insurance industries began to emerge successively in the 17th century. The massive risk and benefit brought by seaborne transport provided a difficult problem to insurers.

  16. Evolution, museums and society.

    Science.gov (United States)

    MacFadden, Bruce J

    2008-11-01

    Visitors to natural history museums have an incomplete understanding of evolution. Although they are relatively knowledgeable about fossils and geological time, they have a poor understanding of natural selection. Museums in the 21st century can effectively increase public understanding of evolution through interactive displays, novel content (e.g. genomics), engaging videos and cyberexhibits that communicate to a broad spectrum of society, both within the exhibit halls as well as outside the museum.

  17. Leadership in Small Societies

    OpenAIRE

    Stephen Younger

    2010-01-01

    Multi-agent simulation was used to study several styles of leadership in small societies. Populations of 50 and100 agents inhabited a bounded landscape containing a fixed number of food sources. Agents moved about the landscape in search of food, mated, produced offspring, and died either of hunger or at a predetermined maximum age. Leadership models focused on the collection and redistribution of food. The simulations suggest that individual households were more effective at meeting their ne...

  18. Radioprotective efficacy and cytogenetic effect of an organoselenium derivative: an in vitro evaluation in Chinese hamster ovary cells

    International Nuclear Information System (INIS)

    With increase in applications of ionizing radiation in medical practices (radiotherapy and nuclear medicine) and also potential accidental exposures to ionizing radiation in various areas of radiation applications such as industrial, nuclear power plants and applications in armed forces, the development of effective radio protector is of great significance and need. The present study was designed to evaluate the in vitro radioprotective efficacy and cytogenetic effect of a novel synthetic organoselenium compound, 3,3'-Diselenodipropionic acid (DSePA), a diselenide and a derivative of selenocystine against damage induced by exposure to 60Co gamma radiation. We have made an attempt to reduce biological damage to as low a level as reasonably possible. The study was carried out by pretreatment (2 hr before irradiation) of test compound to exponentially grown CHO cell cultures at concentrations from 0 to 10 μg/ml. The results have shown that all concentrations tested reduced radiation-induced chromosomal damage compared with cells with no treatment. Maximum protection against radiation damage was observed at the concentration of 2 to 3 μg/ml. The reduction in cytogenetic damage with the radiation dose administered reached to 48%, which represents a significant reduction in gamma-ray induced chromosomal damage. This degree of protection is comparable with that obtained with amifostine, a radioprotective compound used in radiotherapy which is the only FDA approved drug, but characterized by its high cyto-toxicity. DSePA inhibited radiation-induced lipid peroxidation, measured as decrease in thiobarbituric acid reactive substances (TBARS) indicating protective effects on the cellular membrane system. In addition, DSePA treatment scavenged the free radicals and prevented the depletion of glutathione (GSH) level thus protected CHO cells from free-radical-induced oxidative stress. Our results also reflected that DSePA induced the rate of proliferation and attenuated the

  19. A New Orally Active, Aminothiol Radioprotector-Free of Nausea and Hypotension Side Effects at Its Highest Radioprotective Doses

    Energy Technology Data Exchange (ETDEWEB)

    Soref, Cheryl M. [ProCertus BioPharm, Inc., Madison, WI (United States); Hacker, Timothy A. [Department of Medicine, Cardiovascular Physiology Core, University of Wisconsin-Madison, Madison, WI (United States); Fahl, William E., E-mail: fahl@oncology.wisc.edu [ProCertus BioPharm, Inc., Madison, WI (United States); McArdle Laboratory for Cancer Research, University of Wisconsin Carbone Cancer Center, Madison, WI (United States)

    2012-04-01

    Purpose: A new aminothiol, PrC-210, was tested for orally conferred radioprotection (rats, mice; 9.0 Gy whole-body, which was otherwise lethal to 100% of the animals) and presence of the debilitating side effects (nausea/vomiting, hypotension/fainting) that restrict use of the current aminothiol, amifostine (Ethyol, WR-2721). Methods and Materials: PrC-210 in water was administered to rats and mice at times before irradiation, and percent-survival was recorded for 60 days. Subcutaneous (SC) amifostine (positive control) or SC PrC-210 was administered to ferrets (Mustela putorius furo) and retching/emesis responses were recorded. Intraperitoneal amifostine (positive control) or PrC-210 was administered to arterial cannulated rats to score drug-induced hypotension. Results: Oral PrC-210 conferred 100% survival in rat and mouse models against an otherwise 100% lethal whole-body radiation dose (9.0 Gy). Oral PrC-210, administered by gavage 30-90 min before irradiation, conferred a broad window of radioprotection. The comparison of PrC-210 and amifostine side effects was striking because there was no retching or emesis in 10 ferrets treated with PrC-210 and no induced hypotension in arterial cannulated rats treated with PrC-210. The tested PrC-210 doses were the ferret and rat equivalent doses of the 0.5 maximum tolerated dose (MTD) PrC-210 dose in mice. The human equivalent of this mouse 0.5 MTD PrC-210 dose would likely be the highest PrC-210 dose used in humans. By comparison, the mouse 0.5 MTD amifostine dose, 400 {mu}g/g body weight (equivalent to the human amifostine dose of 910 mg/m{sup 2}), when tested at equivalent ferret and rat doses in the above models produced 100% retching/vomiting in ferrets and 100% incidence of significant, progressive hypotension in rats. Conclusions: The PrC-210 aminothiol, with no detectable nausea/vomiting or hypotension side effects in these preclinical models, is a logical candidate for human drug development to use in healthy

  20. A New Orally Active, Aminothiol Radioprotector-Free of Nausea and Hypotension Side Effects at Its Highest Radioprotective Doses

    International Nuclear Information System (INIS)

    Purpose: A new aminothiol, PrC-210, was tested for orally conferred radioprotection (rats, mice; 9.0 Gy whole-body, which was otherwise lethal to 100% of the animals) and presence of the debilitating side effects (nausea/vomiting, hypotension/fainting) that restrict use of the current aminothiol, amifostine (Ethyol, WR-2721). Methods and Materials: PrC-210 in water was administered to rats and mice at times before irradiation, and percent-survival was recorded for 60 days. Subcutaneous (SC) amifostine (positive control) or SC PrC-210 was administered to ferrets (Mustela putorius furo) and retching/emesis responses were recorded. Intraperitoneal amifostine (positive control) or PrC-210 was administered to arterial cannulated rats to score drug-induced hypotension. Results: Oral PrC-210 conferred 100% survival in rat and mouse models against an otherwise 100% lethal whole-body radiation dose (9.0 Gy). Oral PrC-210, administered by gavage 30–90 min before irradiation, conferred a broad window of radioprotection. The comparison of PrC-210 and amifostine side effects was striking because there was no retching or emesis in 10 ferrets treated with PrC-210 and no induced hypotension in arterial cannulated rats treated with PrC-210. The tested PrC-210 doses were the ferret and rat equivalent doses of the 0.5 maximum tolerated dose (MTD) PrC-210 dose in mice. The human equivalent of this mouse 0.5 MTD PrC-210 dose would likely be the highest PrC-210 dose used in humans. By comparison, the mouse 0.5 MTD amifostine dose, 400 μg/g body weight (equivalent to the human amifostine dose of 910 mg/m2), when tested at equivalent ferret and rat doses in the above models produced 100% retching/vomiting in ferrets and 100% incidence of significant, progressive hypotension in rats. Conclusions: The PrC-210 aminothiol, with no detectable nausea/vomiting or hypotension side effects in these preclinical models, is a logical candidate for human drug development to use in healthy humans in

  1. Radioactivity and radioprotection: the every day life in a nuclear installation. Press tour at CEA/GRENOBLE 18 november 1999; Radioactivite et radioprotection: la vie quotidienne dans une installation nucleaire. Voyage de presse au Centre CEA/CADARACHE 18 novembre 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    In the framework of the public information, this paper gives a general information on the radioactivity and the radioprotection at the CEA/Cadarache center. A first part is devoted to a presentation of the radioactivity with definitions and radiation effects on the human being and the environment. An other part presents the radioprotection activities and regulations. The last part deals with specific activities of the CEA/Cadarache: the CASCAD installations for spent fuels storage, the LECA Laboratory for the Examination of Active Fuels and a dismantling installation for big irradiated objects. Historical aspects of the CEA/Cadarache are also provided. (A.L.B.)

  2. Eddy-driven sediment transport in the Argentine Basin: Is the height of the Zapiola Rise hydrodynamically controlled?

    Science.gov (United States)

    Weijer, Wilbert; Maltrud, Mathew E.; Homoky, William B.; Polzin, Kurt L.; Maas, Leo R. M.

    2015-03-01

    In this study, we address the question whether eddy-driven transports in the Argentine Basin can be held responsible for enhanced sediment accumulation over the Zapiola Rise, hence accounting for the existence and growth of this sediment drift. To address this question, we perform a 6 year simulation with a strongly eddying ocean model. We release two passive tracers, with settling velocities that are consistent with silt and clay size particles. Our experiments show contrasting behavior between the silt fraction and the lighter clay. Due to its larger settling velocity, the silt fraction reaches a quasisteady state within a few years, with abyssal sedimentation rates that match net input. In contrast, clay settles only slowly, and its distribution is heavily stratified, being transported mainly along isopycnals. Yet, both size classes display a significant and persistent concentration minimum over the Zapiola Rise. We show that the Zapiola Anticyclone, a strong eddy-driven vortex that circulates around the Zapiola Rise, is a barrier to sediment transport, and hence prevents significant accumulation of sediments on the Rise. We conclude that sediment transport by the turbulent circulation in the Argentine Basin alone cannot account for the preferred sediment accumulation over the Rise. We speculate that resuspension is a critical process in the formation and maintenance of the Zapiola Rise.

  3. Detection of γ-irradiation induced DNA damage and radioprotection of compounds in yeast using comet assay

    International Nuclear Information System (INIS)

    The single cell gel electrophoresis assay (SCGE), a very rapid and sensitive method, has been applied to follow γ-irradiation induced DNA damage in budding yeast, Saccharomyces cerevisiae. Spheroplasting the γ-irradiated yeast cells by enzyme glusulase, before subjecting them to electrophoresis, resulted in a well-defined appearance of comets. Yeast comets look quite different from mammalian comets. A linear relationship was observed between the doses of irradiation and the tail moments of comets. These studies were extended to follow the action of known radio-protectors, i.e., caffeine and disulfiram. The results revealed the usefulness SCGE as applied to yeast in studies of the γ-irradiation-induced DNA breaks and also radio-protection by chemicals at doses that are not feasible with other eukaryotes. (author)

  4. Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

    International Nuclear Information System (INIS)

    FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scale activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs

  5. Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview

    Directory of Open Access Journals (Sweden)

    Jalil Pirayesh Islamian

    2015-01-01

    Full Text Available Radio-protectors are agents that protect human cells and tissues from undesirable ef - fects of ionizing radiation by mainly scavenging radiation-induced free radicals. Although chemical radio-protectors diminish these deleterious side effects they induce a number of unwanted effects on humans such as blood pressure modifications, vomiting, nausea, and both local and generalized cutaneous reactions. These disadvantages have led to emphasis on the use of some botanical radio-protectants as alternatives. This review has collected and organized studies on a plant-derived radio-protector, lycopene. Lycopene protects normal tissues and cells by scavenging free radicals. Therefore, treatment of cells with lycopene prior to exposure to an oxidative stress, oxidative molecules or ion - izing radiation may be an effective approach in diminishing undesirable effects of radia - tion byproducts. Studies have designated lycopene to be an effective radio-protector with negligible side effects.

  6. Evaluation of the radioprotective effects of propolis and flavonoids in gamma-irradiated mice. The alkaline comet assay study

    International Nuclear Information System (INIS)

    The radioprotective effects of water-soluble derivate of propolis (WSDP) collected in Croatia, and single flavonoids, caffeic acid, chrysin and naringin in the whole-body irradiated CBA mice were investigated. Irradiation was performed using a γ-ray source (60Co), and absorbed doses were 4 and 9 Gy. The efficiency of test components was evaluated when given intraperitoneally (i.p.) at dose of 100 mg kg-1 for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of all test components were assessed on non-irradiated animals. The higher efficiency of test components was observed when given preventively. The results suggest that propolis and related flavonoids given to mice before irradiation protected mice from lethal effects of whole-body irradiation and diminish primary DNA damage in their white blood cells as detected by the alkaline comet assay. (author)

  7. Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co γ-rays in Wistar rats

    International Nuclear Information System (INIS)

    Radioprotective effects of sodium tungstate (ST) on 60Co γ-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined. A long term administration of ST (less than 150 mg/kg body weight/day) for 60-300 day had no significant effects on body and organs weights and survival days. The LD50/60 in 20 weeks old rats was 220 mg/kg body weight/day. Daily administration of 38, 75 or 150 mg from 7 days before and after irradiation to 60 days significantly mitigated the decrease in hematocrit values, especially at 23 days after irradiation (P60Co γ-rays significantly. The dose-reduction factor for survival of 38 mg ST administered rats was 1.14. (author)

  8. Operational safety and radioprotection considerations when designing the ILW-LL disposal zone

    International Nuclear Information System (INIS)

    As for any other nuclear industrial facility, in a radioactive waste repository the various waste disposal operational activities from construction to closure can present a risk to human (workers and public) and the environment. In accordance with the December 30, 1991 French Waste Act, Andra has conducted feasibility studies regarding the disposal of HLW and ILW-LL waste in a clay host formation. The 'Dossier 2005 - Clay' includes a description of the operational safety analysis that was conducted for ILW-LL waste disposal in underground horizontal drifts. The objective of this paper is to present that safety analysis and its impact on the design at the feasibility stage. The safety analysis covered the operations from the reception of the waste transport casks to the disposal of the waste disposal package in its final emplacement location inside the disposal cell. Since the surface facilities' operations are similar to those of other nuclear ones, this paper focuses on the specificity of the deep repository, i.e. the operational safety and radioprotection aspects applied to the deep disposal drift. Andra has selected an ILW-LL design based on large horizontal drifts (diameters of 10 to 12 m, and lengths of 250 m). The primary waste packages are put inside a specific concrete overpack before their disposal. These overpacks are remotely stacked inside the horizontal drifts. The operational safety analysis aims to ensure that risks are kept under control through provisions in the design of the repository and by operating the facility in compliance with operational requirements and the safety functions. The requirements and the safety functions, developed at this stage of the feasibility studies, will be explained. The operational safety analysis is structured around physical components and real activities (construction, operation, closure) through a dedicated risk analysis. Due to the large variety of different ILW-LL waste, in order to identify the potential

  9. In vivo radioprotective effects of basic fibroblast growth factor in C3H mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon Shil; Yoon, Sei Chul [Catholic University of Korea, Seoul (Korea, Republic of)

    2002-09-15

    differences in histopathologic findings of lung and mouse sarcoma 180 tumor between radiation alone group and bFGF treated group. Our results suggest that bFGF protects small bowel and bone marrow from acute radiation damage without promoting the inoculated tumor growth in C3H mice. Improved recovery of early responding normal tissue and reduced number of radiation induced apoptosis may be possible mechanism of radioprotective effect of bFGF.

  10. Radioprotective Role of Some Bacteria Belonging to Actinomycetales against Gamma Irradiation-Induced Oxidative Stress in Male Albino Rats

    Directory of Open Access Journals (Sweden)

    Seham Abdel-Shafi1, Tamer M. M. Saad2 *, Abdel-Haliem M. E. F.1, Abdel-Rahman M. A. Ghonemey2, and Gamal Enan1

    2016-07-01

    Full Text Available Background: radiation protection concepts and philosophy have been evolving over the past several decades. The inadvertent exposure of human from various source of radiation causes ionization of molecules, setting off potentially damaging reactions via free radicals production. Development of radioprotectants and mitigators is the therapeutic approach to ameliorate the negative health impact of radiation exposure. The majority of substances with biological activity used in medicine are produced by actinomycetes and fungi. Aim: the aim of the present study is to evaluate the radioprotective role of the antimicrobial active metabolite of Streptomyces atrovirens Rahman as antioxidant against gamma irradiation that induced some biochemical alterations in rats. Material and Methods: animals were pretreated with antimicrobial active metabolite of Streptomyces atrovirens Ab1 using suitable stomach tube for two weeks prior to radiation exposure. The levels of malondialdhyde (MDA, glutathione content (GSH, superoxide dismutase (SOD, catalase (CAT, glutathione peroxidase (GPx, glutamic oxaloacetic transaminase (ALT, glutamic aspartate transaminase (AST, alkaline phosphatase (ALP and gamma glutamyl transferase (GGT activities, also total cholesterol (TC, triglyceride (TG, high density lipoprotein cholesterol (HDL-C, and low density lipoprotein cholesterol (LDL- C were estimated. Results: the results revealed that exposure to ionizing radiation resulted in significant elevation in the levels of MDA content, ALT, AST, ALP and GGT activities and concentration of TC, TG and LDL-C, meanwhile, showed significant depletion in GSH content and SOD, CAT and GPx activities and HDL-C concentration. Conclusion: it could be concluded that, the administration of the antimicrobial active metabolite of Streptomyces atrovirens Ab1 pre-whole body gamma irradiation resulted in sufficient amelioration against radiation effects on the biochemical aspects examined in the present

  11. Radioprotective effect of methanolic root extract of Loeseneriella arnottiana on radiation induced DNA damage in human lymphocytes in vitro

    International Nuclear Information System (INIS)

    Intense exposure to ionization radiation by accidental, occupational or therapeutical purpose causes cellular damage mainly by formation of excessive reactive oxygen species (ROS) or by free radicals. Humans are intentionally exposed to ionising radiation for diagnostic or therapeutic purposes. The use of ionising radiation in cancer therapy may lead to transient and/or permanent injury to normal tissues within the treatment field. To increase the therapeutic index of radiation therapy, various modes of radioprotection have been developed that selectively reduce cytotoxic effects to normal tissues. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical scavenging properties are particularly promising as radioprotectors. Loeseneriella arnottiana, a member of family Hippocrateaceae, is a climbing shrub used by traditional medicine practitioners. To study the antioxidant activity and radioprotective effect of methanolic root extract of Loeseneriella arnottiana against electron beam radiation induced DNA damage in human lymphocytes. Loeseneriella arnottiana roots were dried and extracted using methanol by solvent extraction method. Antioxidant activity was measured by DPPH method. DNA damage was assessed by comet assay parameters. The lymphocytes were incubated for one hour with two different concentrations 10 μg and 50 μg of root extract before exposure to 2 Gy electron beam radiation. 30 μg of methanolic root extract of Loeseneriella arnottiana exhibited 96% radical scavenging activity comparable to 15 μg of ascorbic acid. In reducing power assay it showed dose dependent increase in absorbance indicating that extract is capable of donating hydrogen atoms. Pretreatment of lymphocytes with 10 μg and 50 μg of root extract before irradiation resulted in reduction in the Comet length, Olive tail moment, percentage of DNA in tail when compared to the radiation control group. Results of this

  12. Evaluation of radioprotection properties of propolis by chromosomal alterations, cell proliferation kinetics, mitotic index and sister chromatid exchange

    International Nuclear Information System (INIS)

    A consequence of ionizing radiation is the induction of chromosomal alterations. This causality relation involves that chromosomal alterations can be considered a good indicator of the radiological damage. Some chemical agents can modulate the tissue response to radiation. These compounds are useful because they show certain selectivity, protecting the healthy tissues (radioprotectors) or increasing the sensibility of tissues to radiations (radiosensibilizators). Propolis substance has showed radioprotection properties which are performed in the following study. Propolis is a product of extraordinary interest for both medicine and pharmaceutical industry, since it is assumed to show diverse beneficial health effects. Among many other attributes of EEP (propolis ethanolic extract), it exhibits antioxidant and radical free scavenger properties. In a previous study, human peripheral blood lymphocytes were exposed to 2 Gy of γ rays in presence and absence of EEP, and the analysis showed a reduction in the frequency of dicentrics and rings, with a maximum protection of 50%. The proposed concentration for radioprotection would be between 120-500 μg.ml-1. The cytotoxic effect has been evaluated analyzing the EEP effect in the cellular division cycle. Propolis ethanolic extract (EEP) has been obtained and samples of peripheral blood have been cultured in the presence of increasing concentrations of EEP. In order to quantify it, two indexes have been used, the mitotic index and cell proliferation index. For both indexes the cytotoxic effect takes place from 750 μg.ml-1 concentrations onwards. Similar results were obtained for the analysis of chromosomal aberrations. Finally, propolis effect in lymphocytes by sister chromatid exchange test has been presented for higher concentrations of EEP. (author)

  13. Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+

    Directory of Open Access Journals (Sweden)

    Benjamin Gauter-Fleckenstein

    2014-01-01

    Full Text Available With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(IIImeso-tetrakis(N-n-hexylpyridinium-2-ylporphyrin, MnTnHex-2-PyP5+ has been synthesized and tested in several different model of diseases, where it shows remarkable efficacy at as low as 50 µg/kg single or multiple doses. Yet, in a rat lung radioprotection study, at higher 0.6–1 mg/kg doses, due to its high accumulation and micellar character, it became toxic. To avoid the toxicity, herein the pulmonary radioprotection of MnTnHex-2-PyP5+ was assessed at 50 µg/kg. Fischer rats were irradiated to their right hemithorax (28 Gy and treated with 0.05 mg/kg/day of MnTnHex-2-PyP5+ for 2 weeks by subcutaneously-implanted osmotic pumps, starting at 2 h post-radiation. The body weights and breathing frequencies were followed for 10 weeks post-radiation, when the histopathology and immunohistochemistry were assessed. Impact of MnTnHex-2-PyP5+ on macrophage recruitment (ED-1, DNA oxidative damage (8-OHdG, TGF-β1, VEGF(A and HIF-1α were measured. MnTnHex-2-PyP5+ significantly decreased radiation-induced lung histopathological (H&E staining and functional damage (breathing frequencies, suppressed oxidative stress directly (8-OHdG, or indirectly, affecting TGF-β1, VEGF (A and HIF-1α pathways. The magnitude of the therapeutic effects is similar to the effects demonstrated under same experimental conditions with 120-fold higher dose of ~5000-fold less lipophilic Mn(IIImeso-tetrakis(N-ethylpyridinium-2-ylporphyrin, MnTE-2-PyP5+.

  14. Hydroacoustical evidence of the expansion of pelagic swarms of Munida gregaria (Decapoda, Munididae) in the Beagle Channel and the Argentine Patagonian Shelf, and its relationship with habitat features

    Science.gov (United States)

    Diez, Mariano J.; Cabreira, Ariel G.; Madirolas, Adrián; Lovrich, Gustavo A.

    2016-08-01

    Squat lobsters are highly diversified and widespread decapods, of which only three species form pelagic swarms. Here we infer the expansion of Munida gregaria populations in the Beagle Channel and the Argentine Patagonian Shelf by means of acoustic surveys of pelagic swarms. We also describe the habitat characteristics in which these swarms occur. Acoustic data was collected during three multidisciplinary scientific cruises on board of the R/V Puerto Deseado during 2009, 2012 and 2014. Despite differences in the environmental conditions between the two surveyed areas, between 2009 and 2014 pelagic swarms increased their occurrence and abundance both in the Beagle Channel and on the Argentine Patagonian Shelf. Towards the end of the studied period, pelagic swarms of M. gregaria occurred in new locations, supporting the notion of a population expansion. Within the Beagle Channel swarm expansions were more marked than on the Patagonian Shelf. We here postulate that M. gregaria expansions occur in association with productive areas of the Argentine continental shelf, such as frontal zones, favoured by the squat lobster phenotypic plasticity that permit to exploit resources in both the neritic and benthic environments. At a regional scale on the Patagonian Shelf, three main groups of pelagic swarms of M. gregaria were clearly associated to respective frontal zones. The information presented here is necessary to understand fluctuations in both distribution and abundance patterns of a key species on the Argentine continental shelf. These fluctuations could be direct or indirect indicators of changes in the ecosystem.

  15. American Society of Human Genetics

    Science.gov (United States)

    ... Research Awards August 9, 2016 Media Advisory: American Society of Human Genetics 2016 Annual Meeting July 26, ... McKusick Leadership Award June 30, 2016 The American Society of Human Genetics, Incorporated 9650 Rockville Pike • Bethesda, ...

  16. Heart Failure Society of America

    Science.gov (United States)

    ... Site Terms and Conditions Copyright © 2016 Heart Failure Society of America. All Rights Reserved 2016 Board Review ... Membership Membership Information Membership in the Heart Failure Society is open to all health care professionals with ...

  17. Phoenix Society for Burn Survivors

    Science.gov (United States)

    ... Learn More For First Responders & Medical Professionals Phoenix Society is the leader in connecting the burn recovery ... It can be a... Continue Reading The Phoenix Society, Inc. 1835 RW Berends Dr. SW Grand Rapids, ...

  18. A Novel Synthetic Compound 3-Amino-3-(4-Fluoro-Phenyl)-1H-Quinoline-2,4-Dione (KR22332) Exerts a Radioprotective Effect via the Inhibition of Mitochondrial Dysfunction and Generation of Reactive Oxygen Species

    OpenAIRE

    Baek, Seung Jae; Chang, Jae Won; Park, Keun Hyung; Yang, Garp Yeol; Hwang, Hye Sook; Koh, Yoon Woo; Jung, Young-Sik; Kim, Chul-Ho

    2014-01-01

    Purpose Acute side effects of radiation such as oral mucositis are observed in most patients. Although several potential radioprotective agents have been proposed, no effective agent has yet been identified. In this study, we investigated the effectiveness of synthetic compound 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione (KR22332) as a radioprotective agent. Materials and Methods Cell viability, apoptosis, the generation of reactive oxygen species (ROS), mitochondrial membrane potentia...

  19. Risk and society

    International Nuclear Information System (INIS)

    This book brings together the communications presented at the colloquium 'risk and society' held in Paris (France) on November 1998. During this colloquium, the various aspects of risk and of its management were discussed by medical specialists, historians, industrialists, engineers, philosophers, lawyers, politicians and administration representatives. The first theme concerns the controversies generated by the development of some activities (genetics, bio-technologies, nuclear and radiations use). The second theme concerns the management of risks and the way to conciliate the point of view of authorities and citizens (confidence of the public with respect to experts, scientists, industrialists, government and administrative representatives, role played by the media). The debates that took place during the colloquium have shown that the public opinion concerning the nuclear activities or the new technologies greatly depends on the ideological attitudes and on the public's likes and dislikes with respect to some categories of actors (distrust with respect to public decisions, fears with respect to changes and future, nostalgia of the past). The following aspects are reviewed: Notions of risk and hazard (risk and health, risk in today's society, medicine and society, the point of view of the industrialists and of the scientific and technical specialists); from the psychological aspects of the risk to its social aspects (survey of the risk assessment battlefield, social attenuation and amplification of risk, the feeling of risks in Europe, insecurity and delinquency, controversies around radioactivity and health); the negotiation and communication about risks (risk and public health, negotiation around risks, risks and information dissemination about the public debate, communication and crisis, evolution of risk communication, comparison between American and European approaches, the Seveso directive); the public debate and the evolution of risks management (the

  20. Paradigm, science and society

    Directory of Open Access Journals (Sweden)

    N.T. van der Merwe

    1975-03-01

    Full Text Available The subject of my contribution to the Taljaard Festschrift is focused on a cardinal aspect of the contemporary discussion in the area of theory of science, namely the relationship between science and society', and in this connection especially the role ascribed by certain scholars to paradigms in the practice of science. Because of its bridge function, the first task will be a global getting acquainted with some characteristic accents in contemporary theory of science. If this is successful, it can hopefully open up avenues for a view of the relationship of the remaining two components of the above mentioned subject.

  1. Advanced information society (9)

    Science.gov (United States)

    Kamata, Hiroki

    This article discusses the U.S. and European national strategies and policies for information society. Coping with the declining competitiveness in high-tech products and Japanese technological advantages both have been trying hard to strengthen technology base and to deregulate the telecommunications services markets. The U.S. approach in 1980's, unlike its liberalist principle, has been characterized by technological protectlonism and defense-oriented policies. European Communities' approach has been more comprehensive and systematic, investing heavily telecommunication infrastructure, deregulating domestic market, and promoting cooperation of member countries. However, both of these approaches have, so far, been unable to achieve a considerable success.

  2. Spookytechnology and Society

    CERN Document Server

    Tahan, Charles

    2007-01-01

    New technologies based on the exploitation of so-called "second order" quantum phenomena - such as quantum entanglement - deserve a public-friendly, rational, and sexy name. Spookytechnology is that unifying term. From historical and motivational perspectives, this name has greater value than the many variations of quantum this and quantum that presently used. As many already believe, the pursuit of spookytechnology has profound implications for the development of the physical and information sciences and ultimately for society at large. Spookytechnology will find its place in the increasingly dense line of major technological revolutions of our time: quantum, info, bio, nano, spooky.

  3. Symposia, congresses, societies, meetings

    OpenAIRE

    NN

    1985-01-01

    Please submit your announcement to this Bulletin as early as possible! Several were received too late for interested readers to make use of. After the event please send a summary of the doings and/or the Proceedings, if any. Systematics and Biogeography of the Austral Biota, Canberra, Australia, August 1990. The ninth meeting of the Willi Hennig Society will take place in Canberra, Australia, 24-27 August 1990. The invited and contributed papers will be a mix of theory, methodology, and pract...

  4. Indicators of Information Society Measurement :

    Directory of Open Access Journals (Sweden)

    Hind Elwy

    2006-09-01

    Full Text Available The indicator of information society describe the infrastructure of information and communication technology ; as well as it’s use and it’s production in different estate of society. The importance economic and social of tic is crescent in modern society. and the presentation of tendency inform above the situation of information society . in this article we want to describe the indicator of tic in Algeria according to librarian’s vision in Mentouri university

  5. Education and training in radiological protection in the Argentine region- IAEA, toward a long term commitment

    International Nuclear Information System (INIS)

    The Argentine Republic has extensive antecedents in education and training in radiological protection. From the beginning of the nuclear activity in the country was given preponderance to the aspects related with the radiological protection and the personnel's training involved in the employment of ionizing radiations. At the present time these educational activities already overcome the 50 years, there being accumulated a rich and important experience in the matter. In the country the organisms that have assigned by law the responsibility of the regulation and the control of practice them with ionizing radiations are the Nuclear Regulatory Authority and the Ministry of Health and Atmosphere of the Nation. The first one has the mission of protecting people of the noxious effects of the ionizing radiations derived of nuclear activities, the second is in charge of the control of the equipment dedicated specifically to generate X-rays. This includes the responsibility of elaborating, to emit and to make complete the regulations, standards and other corresponding requirements, in particular - in the mark of the present work - regarding to establish demands and to promote education activities and training in radiological protection. The sure use of the benefits that offers the nuclear development in its diverse applications implies to overturn resources, experience and dedication for the personnel's training. In that sense the Argentina has committed recently to undertake the necessary actions to constitute a Regional Center of Education and Training for Latin America and the Caribbean, taking advantage of the important experience obtained in more of 25 years of imparting graduate degree courses in radiological protection and nuclear safety with inter regional and regional character. With that purpose a process of self evaluation has begun (self appraisal), following the limits settled down by the International Atomic Energy Agency in the document 'Education and

  6. The Pacific-Atlantic connection: Biogeochemical signals in the southern end of the Argentine shelf

    Science.gov (United States)

    Garzón, J. E. Cardona; Martínez, A. M.; Barrera, F.; Pfaff, F.; Koch, B. P.; Freije, R. H.; Gómez, E. A.; Lara, R. J.

    2016-11-01

    The Cape Horn Current transports low-salinity waters from the SE Pacific Ocean into the Atlantic, which are transported further north by the Malvinas current. Biogeochemical signals of this connection were studied by characterization of dissolved organic matter (DOM) by determination of dissolved organic carbon (DOC), fluorescent dissolved organic matter (FDOMc), and DOM humification index (HIX). Further, inorganic nutrients, salinity, temperature, stable isotopic composition of particulate organic nitrogen (δ15N) and chlorophyll a (Chla) were measured in the southern end of the Argentine shelf in March 2012. Three water types were characterized: waters of the Beagle Channel (BCW), coastal waters (CW) and oceanic waters (OW). Highest values of ammonium, DOC, FDOMc and HIX were found in BCW, the lowest in OW, suggesting that terrigenous input is a main source of ammonium and refractory carbon, which is supported by a highly significant inverse correlation of these parameters with salinity. In turn, lowest concentrations of nitrate, silicate and phosphate were found in BCW and CW, and highest in OW, with highly significant correlations of these nutrients with salinity, indicating the contribution of the saltier, nutrient-rich Antarctic Circumpolar Current (ACC) to the Pacific-Atlantic connection system. In general there was an inverse distribution pattern between Chla and those nutrients contributed by the ACC, which is consistent with the transition from coastal waters to the low-silicate, high-nitrate, low-chlorophyll, iron-limited setting of the Subantarctic oceanic waters north of the Polar Front. In contrast, in the low-salinity, internal BCW, high values of ammonium, DOC, HIX and FDOM indicate continental inputs, likely including iron complexes, which could have led to the observed high Chla values. δ15N values were positive in the study region, and same as ammonium, reached a maximum in the inner part of the BCW, declining towards OW. This does not support a

  7. Large-Scale Agricultural Management and Soil Meso- and Macrofauna Conservation in the Argentine Pampas

    Directory of Open Access Journals (Sweden)

    José Camilo Bedano

    2016-07-01

    Full Text Available Soil is the most basic resource for sustainable agricultural production; it promotes water quality, is a key component of the biogeochemical cycles and hosts a huge diversity of organisms. However, we are not paying enough attention to soil degradation produced by land use. Modern agriculture has been successful in increasing yields but has also caused extensive environmental damage, particularly soil degradation. In the Argentine Pampas, agriculturization reached a peak with the generalized use of the no-till technological package: genetically modified soybeans tolerant to glyphosate, no-till, glyphosate, and inorganic fertilizers. This phenomenon has been widely spread in the country; the no-till package has been applied in large areas and has been used by tenants in a 60%–70% of cultivated lands. Thus, those who were involved in developing management practices may not be the same as those who will face degradation issues related to those practices. Indeed, most evidence reviewed in this paper suggests that the most widely distributed practices in the Pampas region are actually producing severe soil degradation. Biological degradation is particularly important because soil biota is involved in numerous soil processes on which soil functioning relies, affecting soil fertility and productivity. For example, soil meso- and macrofauna are especially important in nutrient cycling and in soil structure formation and maintenance, and they are key components of the network that links microbial process to the scale of fields and landscapes where ecosystem services are produced. However, the knowledge of the impact of different agricultural managements on soil meso- and macrofauna in Pampas agroecosystems is far from conclusive at this stage. The reason for this lack of definite conclusions is that this area has been given less attention than in other parts of the world; the response of soil fauna to agricultural practices is complex and taxa

  8. Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay

    International Nuclear Information System (INIS)

    Highlights: • Curcumin and trans-resveratrol can exert radioprotective or radiosensitizing effects. • The mechanisms underlying such dual action were elucidated using the PCC and G2-assay. • Radioprotection occurs in non-cycling cells exposed to curcumin and resveratrol. • Radiosensitization occurs in cycling cells exposed to the chemicals. • G2-checkpoint abrogation by the chemicals underlies the radiosensitizing mechanism. - Abstract: Curcumin and trans-resveratrol are well-known antioxidant polyphenols with radiomodulatory properties, radioprotecting non-cancerous cells while radiosensitizing tumor cells. This dual action may be the result of their radical scavenging properties and their effects on cell-cycle checkpoints that are activated in response to radiation-induced chromosomal damage. It could be also caused by their effect on regulatory pathways with impact on detoxification enzymes, the up-regulation of endogenous protective systems, and cell-cycle-dependent processes of DNA damage. This work aims to elucidate the mechanisms underlying the dual action of these polyphenols and investigates under which conditions they exhibit radioprotecting or radiosensitizing properties. The peripheral blood lymphocyte test system was used, applying concentrations ranging from 1.4 to 140 μM curcumin and 2.2 to 220 μM trans-resveratrol. The experimental design focuses first on their radioprotective effects in non-cycling lymphocytes, as uniquely visualized using cell fusion-mediated premature chromosome condensation, excluding, thus, cell-cycle interference to repair processes and activation of checkpoints. Second, the radiosensitizing potential of these chemicals on the induction of chromatid breaks in cultured lymphocytes following G2-phase irradiation was evaluated by a standardized G2-chromosomal radiosensitivity predictive assay. This assay uses caffeine for G2-checkpoint abrogation and it was applied to obtain an internal control for radiosensitivity

  9. Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay

    Energy Technology Data Exchange (ETDEWEB)

    Sebastià, N., E-mail: natividad.sebastia@uv.es [Radiation Protection Service, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Montoro, A. [Radiation Protection Service, Universitary and Politechnic Hospital La Fe, Valencia (Spain); Grupo de Investigación Biomédica en Imagen GIBI230, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Unidad Mixta de Investigación en Endocrinología, Nutrición y Dietética Clínica, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Hervás, D. [Biostatistics Unit, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Pantelias, G.; Hatzi, V.I. [Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi, Athens (Greece); Soriano, J.M. [Grupo de Investigación Biomédica en Imagen GIBI230, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Unidad Mixta de Investigación en Endocrinología, Nutrición y Dietética Clínica, IIS La Fe, Health Research Institute La Fe, Valencia (Spain); Department of Preventive Medicine and Public Health, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia (Spain); Villaescusa, J.I. [Radiation Protection Service, Universitary and Politechnic Hospital La Fe, Valencia (Spain); and others

    2014-08-15

    Highlights: • Curcumin and trans-resveratrol can exert radioprotective or radiosensitizing effects. • The mechanisms underlying such dual action were elucidated using the PCC and G2-assay. • Radioprotection occurs in non-cycling cells exposed to curcumin and resveratrol. • Radiosensitization occurs in cycling cells exposed to the chemicals. • G2-checkpoint abrogation by the chemicals underlies the radiosensitizing mechanism. - Abstract: Curcumin and trans-resveratrol are well-known antioxidant polyphenols with radiomodulatory properties, radioprotecting non-cancerous cells while radiosensitizing tumor cells. This dual action may be the result of their radical scavenging properties and their effects on cell-cycle checkpoints that are activated in response to radiation-induced chromosomal damage. It could be also caused by their effect on regulatory pathways with impact on detoxification enzymes, the up-regulation of endogenous protective systems, and cell-cycle-dependent processes of DNA damage. This work aims to elucidate the mechanisms underlying the dual action of these polyphenols and investigates under which conditions they exhibit radioprotecting or radiosensitizing properties. The peripheral blood lymphocyte test system was used, applying concentrations ranging from 1.4 to 140 μM curcumin and 2.2 to 220 μM trans-resveratrol. The experimental design focuses first on their radioprotective effects in non-cycling lymphocytes, as uniquely visualized using cell fusion-mediated premature chromosome condensation, excluding, thus, cell-cycle interference to repair processes and activation of checkpoints. Second, the radiosensitizing potential of these chemicals on the induction of chromatid breaks in cultured lymphocytes following G2-phase irradiation was evaluated by a standardized G2-chromosomal radiosensitivity predictive assay. This assay uses caffeine for G2-checkpoint abrogation and it was applied to obtain an internal control for radiosensitivity

  10. American Head and Neck Society

    Science.gov (United States)

    American Head & Neck Society Head and Neck Cancer Research & Education American Head & Neck Society | AHNS Head and Neck Cancer Research & Education About AHNS ... and Announcements Copyright ©2016 · American Head and Neck Society · Privacy and Return Policy Managed by BSC Management, ...

  11. Family in contemporary society

    Directory of Open Access Journals (Sweden)

    Rabije Murati

    2016-01-01

    Full Text Available The family is part of social change and, as such changes and transform into steps with modern trends of society. Family function in a given society is structured according to the overall changes that occur in all areas of social life, not neglecting family life. The contemporary conditions impose requirements that must be met to move forward with the times that follow. In particular, should highlight the social changes that are related to the growth and advancement of the educational and professional standards, which will increase the overall impact on the family and its function. If you're looking for full responsibility of parents in the upbringing of children then it is necessary to see the conditions in which the family lives. For normal education and the rights of children with special meaning the number of members in the (quantity family. The tendency to a higher standard of economic life, a small number of children in the family and it is more than obvious that fewer family members or less have greater opportunity for parents to pay more attention to their children. One of the main roles of family, no matter where they are located in the city, village, developed or developing countries, by all means participate, intermediates and transfers the moral, social and other values in modern life.

  12. CERN & Society launches donation portal

    CERN Multimedia

    Cian O'Luanaigh

    2014-01-01

    The CERN & Society programme brings together projects in the areas of education and outreach, innovation and knowledge exchange, and culture and arts, that spread the CERN spirit of scientific curiosity for the inspiration and benefit of society. Today, CERN & Society is launching its "giving" website – a portal to allow donors to contribute to various projects and forge new relationships with CERN.   "The CERN & Society initiative in its embryonic form began almost three years ago, with the feeling that the laboratory could play a bigger role for the benefit of society," says Matteo Castoldi, Head of the CERN Development Office, who, with his team, is seeking supporters and ambassadors for the CERN & Society initiative. "The concept is not completely new – in some sense it is embedded in CERN’s DNA, as the laboratory helps society by creating knowledge and new technologies – but we would like to d...

  13. Nanotechnology and society

    International Nuclear Information System (INIS)

    Past experience has shown that the successful introduction of a new technology requires careful attention to the interactions between the technology and society. These interactions are bi-directional: on the one hand, technology changes and challenges social patterns and, on the other hand, the governance structures and values of the society affect progress in developing the technology. Nanotechnology is likely to be particularly affected by these kinds of interactions because of its great promise and the unusually early public attention it has received. Moreover, it represents a new kind of experiment in packaging a rather wide range of fundamental research activities under a single 'mission-like' umbrella. Although this gives it more impetus as a field, it sets a higher bar for showing successful applications early on and because it links disparate fields, regulatory regimes reasonable for one kind of nanotechnology development may be inappropriately extended to others. There are a number of lessons to be gleaned from experience with the introduction of other technologies, which offer guidance with respect to what pitfalls to avoid and what issues to be sensitive to as we move forward with the development of nanotechnology applications. The problems encountered by nuclear power point out the dangers of over-promising and the role the need for the technology plays in ameliorating fears of risk. The public reaction to biomedical engineering and biotechnology highlights, in addition, the cultural factors that come into play when technologies raise questions about what is 'natural' and what is 'foreign' and what conceptions are involved in defining 'personhood'. In all cases, it has been clear that a main task for those introducing new technology is building public trust-in the safety of the technologies and the integrity of those introducing it. The advocates of nanotechnology have already shown that they are generally aware of the need to consider the public

  14. Communicating Science to Society

    Science.gov (United States)

    Illingworth, Samuel; Muller, Jennifer; Leather, Kimberley; Morgan, William; O'Meara, Simon; Topping, David; Booth, Alastair; Llyod, Gary; Young, Dominique; Bannan, Thomas; Simpson, Emma; Percival, Carl; Allen, Grant; Clark, Elaine; Muller, Catherine; Graves, Rosemarie

    2014-05-01

    "Nothing in science has any value to society if it is not communicated." So goes the 1952 quote from Anne Roe, the noted twentieth century American psychologist and writer. She went on to say that "scientists are beginning to learn their social obligations", and now over 60 years later there is certainly evidence to support her assertions. As scientists, by communicating our research to the general public we not only better inform the tax payer where their money is being spent, but are also able to help put into context the topical environmental challenges and issues that society faces, as well as inspiring a whole new generation of future scientists. This process of communication is very much a two-way street; by presenting our work to people outside of our usual spheres of contemporaries, we expose ourselves to alternative thoughts and insights that can inspire us, as scientists, to take another look at our research from angles that we had never before considered. This work presents the results and experiences from a number of public engagement and outreach activities across the UK, in which geoscientists engaged and interacted with members of the general public. These include the design and implementation of Raspberry Pi based outreach activities for several hundred high school students; the process of running a successful podcast (http://thebarometer.podbean.com); hosting and participating in science events for thousands of members of the general public (e.g. http://www.manchestersciencefestival.com and http://sse.royalsociety.org/2013); and creating a citizen science activity that involved primary school children from across the UK. In communicating their research it is imperative that scientists interact with their audience in an effective and engaging manner, whether in an international conference, a classroom, or indeed down the pub. This work also presents a discussion of how these skills can be developed at an early stage in the careers of a research

  15. Radioprotective effects in mice by a single dose of subcutaneous administration of cobaltous chloride post γ-rays irradiation with a sublethal dose

    International Nuclear Information System (INIS)

    Radioprotective effects were investigated in mice which received subcutaneously a single dose of each inorganic metal: Co, Cu, Rb, Sr, Mo and W 24 hours post irradiation of 60Co γ-rays with a sublethal dose. The effects were observed in mice injected with Co at an optimum dosage of 20 mg/kg·body weight. Then to elucidate mechanisms of the effects, mice were injected with Co containing the radioactive tracer (60Co) following the radiation exposure, measured elimination of the radioactivity for 7 days, then sacrificed and divided to some tissues and organs. The radioactivity in whole body during this period resulted in a markedly higher retention than that for mice injected with [60Co] alone, as well as liver in the organs. These higher retentions appeared to be related to the radioprotective effects. (author)

  16. Afghanistan, state and society

    DEFF Research Database (Denmark)

    Kværnø, Ole

    In June 2007, the RAND Corporation and the Royal Danish Defence College hosted a conference titled “Afghanistan: State and Society, Great Power Politics, and the Way Ahead”. The two-day event, held in Copenhagen, was attended by more than 100 politicians, scholars, academics, and representative...... of both governmental and nongovernmental institutions from more than 20 states. Its theme was to discuss the problems that Afghanistan faces in the wake of the U.S.-led attack on al Qaeda training camps and the Taliban government; examine the challenges confronting the NATO International Security...... Assistance Force as it coordinates nation-building activities in Afghanistan; and suggest ways to address these issues. This volume compiles 11 of the papers presented at the conference; themes include the importance of historical precedents, coordination among relevant parties, and the development of an all...

  17. Behaviorism and Society.

    Science.gov (United States)

    Krapfl, Jon E

    2016-05-01

    A probable list of causes for the limited acceptance of behaviorism in our society is identified. This is followed by a summary review of the proposed solutions identified in other papers in this special issue of The Behavior Analyst, most of which relate to either better marketing of either the behavior analytic process or the results achieved as a consequence. One paper proposes a more broad conception of behavior analysis. This paper endorses the solutions identified in previous papers and then goes on to propose an even more broad conception of behavior analysis and makes the point that behavior analysis is unlikely to flourish unless behavior analysts understand a good deal more about the cultural and other contextual features of the environments in which they work. PMID:27606191

  18. Popular Music and Society

    DEFF Research Database (Denmark)

    2007-01-01

    Fifteen years after the collapse of the Soviet Union, popular music is thriving in the former Soviet territories and covers a broad variety of genres.  Among these are rock bands formed in the Soviet era, surviving legends of Soviet pop, and younger bands and performers of the 1990s and 2000s.......   Local and foreign musics blend as new impulses arrive from without and arise from within the region.  Thanks to the most recent wave of Russian emigrants, these popular musics have also spread to various localities around the world, as exemplified by the phenomenon of "Russendisko" in Berlin...... or the Russkii Rok-Klub v Amerike (Russian Rock Club of America).   This special edition of Popular Music and Society aims to present research on contemporary popular music (broadly defined) in the former Soviet republics and their diasporas.  A central issue will be how the musical landscape has changed since...

  19. Libraries in Society

    DEFF Research Database (Denmark)

    Kristiansson, Michael; Skouvig, Laura

    brought about by the boom of the internet and the advent of the post-modern globalised knowledge-based and network-organised society. Finally, the paper outlines how theoretical and strategic library development can benefit from academic considerations on the dialectics between openness and restrictedness......The purpose of the paper is to investigate the phenomenon of openness in relation to library development. The term openness is presented and related to library development from historical and theoretical perspectives. The paper elaborates on the differences over time on to how openness has been...... understood in a library setting. Historically, openness in form of the open shelves played a crucial role in developing the modern public library. The paper examines this openness-centred library policy as adopted by Danish public libraries in the beginning of the 20th century by applying the theories...

  20. Expectations from Society

    International Nuclear Information System (INIS)

    Prof. A. Blowers observed that the social context within which radioactive waste management is considered has evolved over time. The early period where radioactive waste was a non-issue was succeeded by a period of intense conflict over solutions. The contemporary context is more consensual, in which solutions are sought that are both technically sound and socially acceptable. Among the major issues is that of inter-generational equity embraced in the question: how long can or should our responsibility to the future extend? He pointed out the differences in timescales. On the one hand, geo-scientific timescales are very long term, emphasizing the issue of how far into the future it is possible to make predictions about repository safety. By contrast, socio cultural timescales are much shorter, focusing on the foreseeable future of one or two generations and raising the issue of how far into the future we should be concerned. He listed. the primary expectations from society which are: safety and security to alleviate undue burdens to future generations and flexibility in order to enable the future generations to have a stake in decision making. The need to reconcile the two had led to a contemporary emphasis on phased geological disposal incorporating retrievability. However, the long timescales for implementation of disposal provided for sufficient flexibility without the need for retrievability. Future generations would inevitably have sold stake in decision making. Prof. A.. Blowers pointed out that society is also concerned with participation in decision making for implementation. The key elements for success are: openness and transparency, staged process, participation, partnership, benefits to enhance the well being of communities and a democratic framework for decision making, including the ratification of key decisions and the right for communities to withdraw from the process up to a predetermined point. This approach for decision making may also have

  1. Methodology for inspection parametrization of radioprotection at radioactive installations: a research agenda; Metodologia para parametrizacao de inspecoes de radioprotecao em instalacoes radioativas: uma agenda de pesquisa

    Energy Technology Data Exchange (ETDEWEB)

    Filgueiras, Bruno Costa [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Sauerbronn, Fernanda F., E-mail: fernanda.sauerbronn@facc.ufrj.b [Universidade Federal do Rio de Janeiro (FACC/UFRJ), RJ (Brazil). Faculdade de Administracao e Ciencias Contabeis

    2011-10-26

    This paper establishes a research agenda based on documental and bibliographic research for radioprotection inspection parametrization at radioactive installations, which is one of the constitutional attributions of Brazilian Nuclear Energy Commission. Such proposal, aiming to guarantee that the evaluation of normative requests of radiation protection generated a quantitative result, useful for various institutions in the safety and regulation areas, bringing relevant contribution for the sector

  2. Modalities of declaration and codification of criteria related to significant events in the field of radioprotection besides base nuclear installations and transports of radioactive substances

    International Nuclear Information System (INIS)

    This document specifies provisions which must be applied by those in charge of a nuclear activity when declaring significant events regarding radioprotection. It describes the general principles, evokes the declaration criteria (they are more precisely presented in appendix), the declaration delay, and the declaration modalities (the informant, the documents, the addressee). It also evokes obligations regarding population information. A declaration form and a model of event report are provided in appendix

  3. Co-operation agreement. The text of the agreement of 25 May 1998 between the International Atomic Energy Agency and the Brazilian-Argentine Agency for accounting and control of nuclear materials

    International Nuclear Information System (INIS)

    The document reproduces the text of the Co-operation Agreement between the International Atomic Energy Agency and the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials which entered into force on 25 May 1998

  4. Tectonique Cénozoïque du Haut Plateau de la Puna, Nord Ouest Argentin, Andes Centrales.

    OpenAIRE

    Coutand, Isabelle

    1999-01-01

    Mémoires de Géosciences Rennes, n° 92, 381 p., ISBN: 2-905532-91-2 Les Andes Centrales sont l'exemple type d'une chaîne se développant le long d'une marge active en contexte non collisionel et résultent de la subduction légèrement oblique (-N75°E) de la plaque océanique Nazca sous le continent sud-américain. Elles sont caractérisées par la présence du haut plateau de l'Altiplano-Puna s'étendant depuis le Pérou au Nord jusqu'en Argentine au Sud et présentant une altitude moyenne avoisinant ...

  5. Images and symbols of nuclear energy and environment in Argentine public opinion: the need of a new strategy

    International Nuclear Information System (INIS)

    The need to create in the Argentine public opinion new positives symbols and images on nuclear energy and on the benefits of its peaceful applications, is al present so important as the development of new technical tools to improve the nuclear industry. These positives symbols and imagines on nuclear energy must be created in the framework of a joint strategy of all the country's nuclear institutions as well as other public organizations, in view of the new nuclear plan recently announced. This joint strategy will permit to create not only the new positives symbols and images in the public opinion, but also to obtain the support of the mass media and new spaces for negotiation in the national, provincial and municipal levels. (author)

  6. Secrets, Trauma, and the Memory Market (or the return of the repressed in recent Argentine post-dictatorship cultural production

    Directory of Open Access Journals (Sweden)

    Silvia R Tandeciarz

    2012-04-01

    Full Text Available Since the end of the last Argentine Dictatorship (1976-1983, a number of feature-length films have engaged in the public debate over the legacies of state terrorism. El secreto de sus ojos (2009, Argentina's most recent Oscar winner, is the latest to do so, exploring the effects of more than a decade of impunity on those who lost their loved ones. Suggesting that restoration of a justice system that works can lead to the restoration of full civic engagement in a healthy body politic, the film raises important questions about citizenship and belonging in a post-national era. This essay explores the film's phenomenal success in the global memory market to illuminate what remains at stake in contemporary narratives of reconciliation.

  7. En torno a la desilusión argentina On Argentine disillusionment

    Directory of Open Access Journals (Sweden)

    Andrés Kozel

    2007-12-01

    its emergence with general social and economic processes?; How can we extract the incidents of this idea?; How can we characterize and classify its main expressions?; How can we think about the global meaning of this ideological and political process? The general exposition of the research is focused on showing that the topic of the failure acquired its decisive attributes during the first half of the 20th century, through a complex dynamic, comprised of diverse channels which should be captured in their specificity, although without losing sight of the more general movement of which they form a part: seen globally, this movement contributed to the erosion of an entire ideological-cultural configuration, which I call "argentine illusion". The backdrop of the process was none other than the growing social complexity, the greater and more dissonant discursive diversification (Tulio Halperín and the profound hegemony crisis which the country experienced throughout the period.

  8. Italian and Argentine olive oils: a NMR and gas chromatographic study

    Directory of Open Access Journals (Sweden)

    Segre, Annalaura

    2001-12-01

    Full Text Available High-field Nuclear Magnetic Resonance (NMR spectroscopy and Gas Chromatography (GC were used to analyze 16 monovarietal olive oils obtained from few matched Mediterranean cultivars grown in experimental fields located in Italy and in the Catamarca region of Argentina. The Catamarca region is characterized by extreme pedoclimatic conditions and by a wild spontaneous vegetation. The proposed sampling allows to study the effect of different pedoclimatic conditions on olive oil composition. GC gives the fatty acid profile of olive oil samples. 1H and 13C NMR techniques provide different information: the 1H NMR spectrum allows the measurement of minor components of olive oils such as b-sytosterol, hexanal, trans-2-hexenal, formaldehyde, squalene, cycloartenol and linolenic acid; the 1C NMR spectrum allows to obtain information about glycerol tri-esters of olive oils, i.e., about their acyl composition and positional distribution on glycerol moiety. All the NMR and GC results have been submitted to Linear Discriminant Analysis (LDA and Tree Cluster Analysis (TCA. A careful analysis of the statistical results allows to select the Mediterranean cultivars less affected by the climatic conditions present in the Catamarca region. The selected cultivars produce olive oils which keep their Mediterranean characteristics and which can be proposed as colonizing plants in this wild Argentine region.La espectroscopía de Resonancia Magnética Nuclear de alta resolución (RMN y Cromatografía Gaseosa (CG fueron utilizadas para analizar 16 monovariedades de aceites de oliva, obtenidas de algunos olivares Mediterráneos cultivados contemporáneamente en campos experimentales localizados en Italia y en la región de Catamarca en Argentina. Estas muestras permiten estudiar diferentes condiciones pedoclimáticas en la composición de los aceite de oliva. La CG proporciona el perfil en ácidos grasos de los aceites de oliva y las técnicas RMN 1H y RMN 13C suministran

  9. Structure, composition and metagenomic profile of soil microbiomes associated to agricultural land use and tillage systems in Argentine Pampas.

    Directory of Open Access Journals (Sweden)

    Belén Carbonetto

    Full Text Available Agriculture is facing a major challenge nowadays: to increase crop production for food and energy while preserving ecosystem functioning and soil quality. Argentine Pampas is one of the main world producers of crops and one of the main adopters of conservation agriculture. Changes in soil chemical and physical properties of Pampas soils due to different tillage systems have been deeply studied. Still, not much evidence has been reported on the effects of agricultural practices on Pampas soil microbiomes. The aim of our study was to investigate the effects of agricultural land use on community structure, composition and metabolic profiles on soil microbiomes of Argentine Pampas. We also compared the effects associated to conventional practices with the effects of no-tillage systems. Our results confirmed the impact on microbiome structure and composition due to agricultural practices. The phyla Verrucomicrobia, Plactomycetes, Actinobacteria, and Chloroflexi were more abundant in non cultivated soils while Gemmatimonadetes, Nitrospirae and WS3 were more abundant in cultivated soils. Effects on metabolic metagenomic profiles were also observed. The relative abundance of genes assigned to transcription, protein modification, nucleotide transport and metabolism, wall and membrane biogenesis and intracellular trafficking and secretion were higher in cultivated fertilized soils than in non cultivated soils. We also observed significant differences in microbiome structure and taxonomic composition between soils under conventional and no-tillage systems. Overall, our results suggest that agronomical land use and the type of tillage system have induced microbiomes to shift their life-history strategies. Microbiomes of cultivated fertilized soils (i.e. higher nutrient amendment presented tendencies to copiotrophy while microbiomes of non cultivated homogenous soils appeared to have a more oligotrophic life-style. Additionally, we propose that conventional

  10. Structure, composition and metagenomic profile of soil microbiomes associated to agricultural land use and tillage systems in Argentine Pampas.

    Science.gov (United States)

    Carbonetto, Belén; Rascovan, Nicolás; Álvarez, Roberto; Mentaberry, Alejandro; Vázquez, Martin P

    2014-01-01

    Agriculture is facing a major challenge nowadays: to increase crop production for food and energy while preserving ecosystem functioning and soil quality. Argentine Pampas is one of the main world producers of crops and one of the main adopters of conservation agriculture. Changes in soil chemical and physical properties of Pampas soils due to different tillage systems have been deeply studied. Still, not much evidence has been reported on the effects of agricultural practices on Pampas soil microbiomes. The aim of our study was to investigate the effects of agricultural land use on community structure, composition and metabolic profiles on soil microbiomes of Argentine Pampas. We also compared the effects associated to conventional practices with the effects of no-tillage systems. Our results confirmed the impact on microbiome structure and composition due to agricultural practices. The phyla Verrucomicrobia, Plactomycetes, Actinobacteria, and Chloroflexi were more abundant in non cultivated soils while Gemmatimonadetes, Nitrospirae and WS3 were more abundant in cultivated soils. Effects on metabolic metagenomic profiles were also observed. The relative abundance of genes assigned to transcription, protein modification, nucleotide transport and metabolism, wall and membrane biogenesis and intracellular trafficking and secretion were higher in cultivated fertilized soils than in non cultivated soils. We also observed significant differences in microbiome structure and taxonomic composition between soils under conventional and no-tillage systems. Overall, our results suggest that agronomical land use and the type of tillage system have induced microbiomes to shift their life-history strategies. Microbiomes of cultivated fertilized soils (i.e. higher nutrient amendment) presented tendencies to copiotrophy while microbiomes of non cultivated homogenous soils appeared to have a more oligotrophic life-style. Additionally, we propose that conventional tillage systems may

  11. Technical-economic analysis of the 'Tandem' fuel cycle. A study of the Brazil-Argentine case

    International Nuclear Information System (INIS)

    Advanced fuel cycles, nuclear power reactors, are studied all over the world nowadays, mainly as a way of enhancing the use of nuclear fuel. Such goal is usually decomposed under tree main aspects: environmental, economical and strategic. The Tandem Cycle has demonstrated, under these aspects, to be one of the most promising options among the advanced cycles. This cycle deals, basically, with the reutilization of irradiated ('burned') fuel in PWR type reactors, in CANDU type reactors, as this fuel also contains about 1.5% of fissile material. Brazilian and Argentine nucleoelectric generation options are, coincidentally, in accordance with this option of advanced cycle. This work thus deals with the viability analysis, both technical and economic, of the implementation of a Tandem cycle between the brazilian reactor of Angra-I (PWR) and the argentine reactor of Embalse (CANDU). Tree options of Tandem Cycle have been analysed specifically for the reactors in question. For this analysis, a methodology was developed and a computer program was designed to analyse the technical and economical parts of these options. Besides, countless details have been considered, such as: the influence of actinide elements, test and adjustment of the nuclear data library utilized in the calculations, observation of the safety and control of the CANDU reactor operating on the Tandem Cycle, etc. Given the analyses done, the adoption of the Tandem Cycle-2, in which the fuel irradiated from the PWR is diluted in depleted uranium, was suggested for an occasional implementation of this option of advanced fuel cycle between the reactors of Angra-I and Embalse as a general conclusion of this work. (author)

  12. Determination of selenium in mice tissues to understand pharmacokinetics of diselenium propionic acid (DSePA) - a radioprotective agent

    International Nuclear Information System (INIS)

    Radiation therapy is one of the common modality for treatment of cancer which is associated with acute and chronic side effects. Recently pre-clinical and clinical studies have shown selenium analogues to be an effective radio-protective agent. One such analogue of selenium, diselenium propionic acid (DSePA), offered significant protection to normal tissue from radiotherapy induced toxicity in mice. Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre has undertaken a systematic development of DSePA as a radioprotective agent. The plasma kinetics and biodistribution of this compound in SCID mice bearing a breast cancer xenograft has been studied. ACD supported this study by standardizing procedure for analysis of different tissue samples. About 150 samples of various tissues of mice were analyzed for Se. The following dissolution protocol was optimised. The entire tissue samples were weighed accurately in a microwave digestion vessel, to this 5 mL HNO3 and 2 mL nanopure water was added. It was subjected to an optimized digestion programme in the microwave system. Digestion of tissue samples in closed vessel microwave system ensured that there were no volatilization losses of Se, during the process. Further, nitric acid treatment ensured that Se present in the sample is converted to Se (IV). The completely dissolved sample solutions were transferred to 10 mL volumetric flask and made upto volume. Se in the solutions was determined using optimized graphite furnace program. To minimize volatilization losses during atomization, Pd(II) (1 mg/mL) was used as modifier while introducing the sample to the graphite tube. Calibration graph was prepared in the range from 10 ng mL-1 to 200 ng mL-1. Samples were suitably diluted to get Se concentration within the linear calibration range. Reagent blanks were prepared along with the samples for blank correction. DSePA concentration was estimated at different time intervals (15 min, 30 min

  13. Evolving society and mental health

    OpenAIRE

    Dipesh Bhagabati; Anil Kumar

    2016-01-01

    Numerous issues related to culture, occupation, gender, caste, and health, to name a few, have faced harshness of society from time immemorial. Reasons are debatable, ranging from somewhat understandable to completely unacceptable. There is no doubt that society is dynamic and it has changed its view on many of the issues with passing time. Mental health is one such issue which society has neglected for quite a long time. Even today, mental health and mentally ill people face stigma and discr...

  14. Intercultural Comunication in Modern Society

    OpenAIRE

    Leontik, Marija

    2012-01-01

    Abstract: Modern society needs the active engagement of individuals in every level of modern life because some of them do not have the opportunity and capacity to perform at the desired level and sometimes are likely to transmit prejudices to their environment. Modern society should offer new aspects in the intercultural communication, so that people will have the opportunity to over¬come their prejudices and prevent them from becoming a barrier in their life. Especially modern society re...

  15. Information Society Development in Bulgaria

    OpenAIRE

    Chobanova, Rossitsa

    2003-01-01

    The rapidly changing nature of modern societies needs to enable the benchmarking of progress through statistical indicators. The book is taking up the challenge of using newly developed innovative information society indicators, tested and piloted in a representative survey held in all EU Member States, Switzerland and the United States in 2002 and in ten new associated states in 2003. The first part of the book concerns benchmarking Information society development in Bulgaria. The topics...

  16. Climate Extremes and Society

    Science.gov (United States)

    Mote, Philip

    2009-10-01

    In October 2005, as the United States still was reeling from Hurricane Katrina in August and as the alphabet was too short to contain all of that year's named Atlantic tropical storms (Hurricane Wilma was forming near Jamaica), a timely workshop in Bermuda focused on climate extremes and society (see Eos, 87(3), 25, 17 January 2006). This edited volume, which corresponds roughly to the presentations given at that workshop, offers a fascinating look at the critically important intersection of acute climate stress and human vulnerabilities. A changing climate affects humans and other living things not through the variable that most robustly demonstrates the role of rising greenhouse gases—globally averaged temperature—but through local changes, especially changes in extremes. The first part of this book, “Defining and modeling the nature of weather and climate extremes,” focuses on natural science. The second part, “Impacts of weather and climate extremes,” focuses on societal impacts and responses, emphasizing an insurance industry perspective because a primary sponsor of the workshop was the Risk Prediction Initiative, whose aim is to “support scientific research on topics of interest to its sponsors” (p. 320).

  17. American Society of Nuclear Cardiology

    Science.gov (United States)

    ... much more! class="box-li"> Journal of Nuclear Cardiology Official publication of the American Society of Nuclear Cardiology Clinical Guidelines Procedures, Appropriate Use Criteria, Information Statements ...

  18. Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses From Trigeminal Neuralgia Radiosurgery?

    International Nuclear Information System (INIS)

    Purpose: Laboratory studies have documented radioprotective effects with carbamazepine. We sought to determine whether carbamazepine or other anticonvulsant/neuroleptic drugs would show significant radioprotective effects in patients undergoing high-dose small-volume radiosurgery for trigeminal neuralgia. Methods and Materials: We conducted a retrospective review of 200 patients undergoing Gamma Knife (Elekta Instrument AB, Stockholm, Sweden) stereotactic radiosurgery for trigeminal neuralgia between February 1995 and May 2008. We selected patients treated with a maximum dose of 80 Gy with 4-mm diameter collimators, with no previous microvascular decompression, and follow-up ≥6 months (median, 24 months; range, 6–153 months). At the time of radiosurgery, 28 patients were taking no anticonvulsants, 62 only carbamazepine, 35 only gabapentin, 21 carbamazepine plus gabapentin, 17 carbamazepine plus other anticonvulsants, and 9 gabapentin plus other anticonvulsants, and 28 were taking other anticonvulsants or combinations. Results: Pain improvement developed post-radiosurgery in 187 of 200 patients (93.5%). Initial complete pain relief developed in 84 of 200 patients (42%). Post-radiosurgery trigeminal neuropathy developed in 27 of 200 patients (13.5%). We could not significantly correlate pain improvement or initial complete pain relief with use of carbamazepine, gabapentin, or use of any anticonvulsants/neuroleptic drugs or other factors in univariate or multivariate analysis. Post-radiosurgery numbness/paresthesias correlated with the use of gabapentin (1 of 36 patients with gabapentin vs. 7 of 28 without, p = 0.017). In multivariate analysis, decreasing age, purely typical pain, and use of gabapentin correlated (p = 0.008, p = 0.005, and p = 0.021) with lower risks of developing post-radiosurgery trigeminal neuropathy. New post-radiosurgery numbness/paresthesias developed in 3% (1 of 36), 5% (4 of 81), and 13% (23 of 187) of patients on gabapentin alone, with

  19. Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses From Trigeminal Neuralgia Radiosurgery?

    Energy Technology Data Exchange (ETDEWEB)

    Flickinger, John C. [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); College of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA (United States); Kim, Hyun [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Kano, Hideyuki [Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Greenberger, Joel S.; Arai, Yoshio [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Niranjan, Ajay [Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Lunsford, L. Dade; Kondziolka, Douglas [Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Flickinger, John C., E-mail: flickingerjc@upmc.edu [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States)

    2012-07-15

    Purpose: Laboratory studies have documented radioprotective effects with carbamazepine. We sought to determine whether carbamazepine or other anticonvulsant/neuroleptic drugs would show significant radioprotective effects in patients undergoing high-dose small-volume radiosurgery for trigeminal neuralgia. Methods and Materials: We conducted a retrospective review of 200 patients undergoing Gamma Knife (Elekta Instrument AB, Stockholm, Sweden) stereotactic radiosurgery for trigeminal neuralgia between February 1995 and May 2008. We selected patients treated with a maximum dose of 80 Gy with 4-mm diameter collimators, with no previous microvascular decompression, and follow-up {>=}6 months (median, 24 months; range, 6-153 months). At the time of radiosurgery, 28 patients were taking no anticonvulsants, 62 only carbamazepine, 35 only gabapentin, 21 carbamazepine plus gabapentin, 17 carbamazepine plus other anticonvulsants, and 9 gabapentin plus other anticonvulsants, and 28 were taking other anticonvulsants or combinations. Results: Pain improvement developed post-radiosurgery in 187 of 200 patients (93.5%). Initial complete pain relief developed in 84 of 200 patients (42%). Post-radiosurgery trigeminal neuropathy developed in 27 of 200 patients (13.5%). We could not significantly correlate pain improvement or initial complete pain relief with use of carbamazepine, gabapentin, or use of any anticonvulsants/neuroleptic drugs or other factors in univariate or multivariate analysis. Post-radiosurgery numbness/paresthesias correlated with the use of gabapentin (1 of 36 patients with gabapentin vs. 7 of 28 without, p = 0.017). In multivariate analysis, decreasing age, purely typical pain, and use of gabapentin correlated (p = 0.008, p = 0.005, and p = 0.021) with lower risks of developing post-radiosurgery trigeminal neuropathy. New post-radiosurgery numbness/paresthesias developed in 3% (1 of 36), 5% (4 of 81), and 13% (23 of 187) of patients on gabapentin alone, with age

  20. Digital Denmark: From Information Society to Network Society

    DEFF Research Database (Denmark)

    Henten, Anders; Falch, Morten

    2000-01-01

    The Danish Government recently issued a new policy report, Digital Denmark, on the "conversion to a network society", as a successor to its Information Society 2000 report (1994). This is part of a new round of information society policy vision statements that are, or will be forthcoming from...... for a welfare society. However, globalisation and the spreading use of new information and communication technologies and services challenge this position. This article examines Denmark's performance in implementing its IS 2000 plans, the background to the Digital Denmark report, and its implications...... national governments everywhere. Denmark provides an interesting case study because it ranks high in the benchmark indicators of information network society developments. This position has been obtained largely by public sector initiatives and without erosion of the highly reputed Scandinavian model...

  1. Knowledge society training system

    International Nuclear Information System (INIS)

    The paper aims to present the results of the Cernavoda NPP Training Department modernization project. In order to achieve a knowledge society training system, in the first stage of the project a Computer Based Training (CBT) or E-Learning software platform and several CBT objects/courses have been implemented. The conceived solution is called CBTCenter which is a complete E-Learning and CBT system, offering a variety of teaching and learning tools and services to its users. CBT and/or E-Learning always mean two things: a software platform and content authoring. Ideally, a software platform should be able to import any type of flat documentation and integrate it into a structured database which keeps track of pedagogically meaningful information like the student's progress in studying materials, tests and quizzes, grades, etc. At the same time, the materials, the study and the tests have to be organized around certain objectives which play the role of guidelines during the entire educational activity. An example of such a course which has been successfully integrated into CBTCenter is Labour safety - code name BB-001. The implementation of the CBT technology at NPP Cernavoda Training Department has brought several advantages: the technology improves overall communication between all individuals which take part in the educational process; the classroom space problem has been considerably reduced; students can access training materials from their own desk using the NPP intranet; the logistics problems will decrease with the conversion of more and more conventional courses and materials into CBT objects/courses. (authors)

  2. Facing the challenge of stakeholders involvement: the Argentine nuclear regulatory case

    International Nuclear Information System (INIS)

    The Nuclear Regulatory Authority of Argentina (ARN) is an autonomous body reporting to the Presidency of Argentina, empowered to regulate and control the nuclear activity with regards to radiation and nuclear safety, physical protection and nuclear non-proliferation issues. Under the executive decree 1172/2003, which makes reference to the accessibility of public information to increase transparency of government actions and specially to promote public involvement, ARN has the legal obligation to inform of its activities in an accurate, comprehensive and understandable manner. The re-launching of the nuclear plan in 2006 and the repercussions this provoked on society highlighted the need to reinforce the legitimacy of the regulatory role and the promotion of confidence on its works to ensure the safety of the people. Therefore it was considered necessary to involve the society further in this programme by achieving greater public understanding and awareness of the nuclear regulatory activities. The more the public is conscious of the role of the regulator, conceiving it as a trustworthy and autonomous authority, the easier it is for the regulator to fulfil its obligations. As ARN has a strong commitment with society and considering that communication with the general public, as an external stakeholder, is a means to establishing and maintaining public trust and confidence, the implementation of a new communication programme became a key issue. In this scenario, ARN faced a challenge it was not prepared to handle and thus created a Division to deal with institutional communication and allow and ease the interaction with society. Within this Division, one of the methods chosen to achieve a better interaction with society was the use of a technological tool to attend possible inquiries, increasing and facilitating a greater involvement of the stakeholders. With this in mind a 'Mail-Info' was established because it allows a fast, accessible, easy and informal way of

  3. Public Libraries in postindustrial societies

    DEFF Research Database (Denmark)

    Elbeshausen, Hans

    2015-01-01

    The article’s focus is on how public libraries are affected by structural changes in the wake of the transition to the knowledge society. Their attempts to match the knowledge society are illustrated by processes of sensemaking and sensegiving made in public libraries in Canada, the UK and Denmark....

  4. Making the Good Society Work

    Science.gov (United States)

    Field, John

    2010-01-01

    Everyone is talking about civil society. Perhaps it's the election, and the shock of seeing more voters at the polling booths than anyone had expected. Now David Cameron's idea of a "big society" is being translated into some early policy measures. Does today's debate have anything to do with adult learning? The author believes that the debate…

  5. Can democracy educate a society?

    OpenAIRE

    Gersbach, Hans; Siemers, Lars-H. R.

    2005-01-01

    We examine whether democratic societies can escape poverty traps. Unrestricted agenda setting with simple majority rules fail to educate a society, because education-enhancing redistribution will not occur. We show that a combination of suitable constitutional rules overcomes this impossibility result: rotating agenda setting and agenda repetition in combination with flexible majority rules or with a tax protection rule.

  6. Education in the Information Society

    OpenAIRE

    Octavia-Luciana Porumbeanu

    2007-01-01

    This article approaches the fundamental role which education has in the information society. The continuous evolution of information and communication technologies requires that all citizens have the necessary skills have to use these technologies and to access information for efficient individual functioning in the information society. In this context, the information literacy programmes have a growing importance.

  7. The Learning Society: Two Justifications

    Science.gov (United States)

    Su, Ya-hui

    2010-01-01

    This article examines the view that has long been fashionable in related policies and literature that the establishment of the learning society is a necessary response to changing times. This article suggests that the association between the learning society and current change may be defensible but is limited. The justification of the learning…

  8. Education in the Information Society

    Directory of Open Access Journals (Sweden)

    Octavia-Luciana Porumbeanu

    2007-01-01

    Full Text Available This article approaches the fundamental role which education has in the information society. The continuous evolution of information and communication technologies requires that all citizens have the necessary skills have to use these technologies and to access information for efficient individual functioning in the information society. In this context, the information literacy programmes have a growing importance.

  9. A comparative study on radioprotective effect of N-acetylcysteine against 12C6+ ion versus X-rays

    Science.gov (United States)

    Liu, Yang; Zhang, Hong; Zhang, Luwei

    Purpose: The aim of this study was to evaluate the different protective efficacy of N-acetylcysteine (NAC, 200 mg/kg dose) against 12C6+ ion (4 Gy) and X-rays (4 Gy) - induced damage in vivo model. Method: Kung-Ming female mice were divided into six groups, each composed of twelve animals: control group, two irradiation groups, and two NAC-treated groups, as well as NAC alone-treated group. An acute study was carried out to determine alterations in the oxidative stress (malondialdehyde level) using with colorimetric method and cell apoptosis measuring by flow cytometry as well as DNA-single strand break analyzing by comet assay at 2h after irradiation in mouse liver. Results: Compared with respective irradiation group, NAC can significantly ameliorate injury induced by two types of ionizing irradiation, which marked by the decrease of malondialdehyde level, and the reduction of apoptosis cells percentage and DNA damage. But the greater efficacy of NAC was prominently observed to inhibit the damage induced by X-rays, suggesting that NAC-mediated protective effect is more advisable to X-rays than 12C6+ ion irradiation. Moreover, NAC treatment alone did not result in any damage as compared to the control group. Conclusion: NAC may merit development as a potential radioprotective agent. Furthermore, NAC might exert its best effort to respond X rays-caused damage.

  10. Study of the radioprotective efficiency of combined administration of natural antioxidants and a sulfhydryl compound in feverish irradiated rats

    International Nuclear Information System (INIS)

    In the present experiments, a study of the radioprotective effects of natural antioxidants, rutin alone, vitamine E alone or each of them combined with synthetic radioprotector, cysteine have been investigated in irradiated and feverish irradiated rats. Furthermore, the oxidative stress bio markers and certain liver function tests of the irradiated and the feverish whole body irradiated rats were examined. Two main sets of animals were used: The 1st set was constructed in order to study the effect of irradiation, while the second set was used to study the effect of irradiation on feverish rats. The effect of irradiation was evaluated by exposing the whole body of rats to gamma radiation at acute single dose level of 6.5 Gy. Rutin was orally daily administered for two weeks before irradiation in a dose of 1.064 mmol/kg , vitamine E was injected intraperitoneally daily for seven days before irradiation in a dose of 50 mg/100 g. While, cysteine was intraperitoneally administered only 30 min. before irradiation in a dose of 30 mg/kg. In order to determine the antipyretic effect of the drugs, body temperature of each animal was measured before induction of hyperthermia as well as 18 hours following yeast injection. Rats were treated with the tested drugs before induction of fever then exposed to whole body gamma radiation at acute single dose level of 6.5 Gy and body temperature of each animal was measured 3 days after irradiation

  11. Radioprotective effect of Hatakeshimeji(lyophyllum decastes) on the organogenesis stage of fetus and haemopoietic cells in ICR mice

    International Nuclear Information System (INIS)

    The organogenesis stage of embryos in ICR mice is most sensitive for radiation. We paid attention to the radioprotective effect of a Hatakeshimeji (Lyophyllum decastes) on the radiation-induced malformation at the organogenesis stage, embryonic death and the effects of Hatakeshimeji (Lyophyllum decastes) on the In vivo level of the fetuses. ICR mouse from Japan National Institute of Health was used for the experiment. One or two female mice and one male mouse of shame age range were mated for only three hours from 8:00 to 11:00. The pregnant mice were placed in plastic cages for radiation exposure, and were treated with a single whole-body X -radiation at 1 Gy with a dose rate of 35 cGy/min on 8 days after the conception. 100 mg/kg of Hatakeshimeji (Lyophyllum decastes) (isotonic sodium chloride solution: 0.2 ml) was injected by i.p.route to the pregnant mice. The embryonic death, external malformations, fetal body weight, sex ratio and embryonic death were observed in these experiments

  12. Radioprotective effect of Hatakeshimeji(lyophyllum decastes) on the organogenesis stage of fetus and haemopoietic cells in ICR mice

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Yeunhwa; Ukawa, Yuuichi; Suzuki, Ikukatsu; Park, Sangrea; Tanaka, Masashi; Matsumori, Masaki; Oshima, Masami; Hayashi, Ikuo; Hasegawa, Takeo [Suzuka Univ. of Medical Science, Suzuka (Japan); Rhee, Soo Young [Hanyang Univ., Ansan (Korea, Republic of)

    2002-07-01

    The organogenesis stage of embryos in ICR mice is most sensitive for radiation. We paid attention to the radioprotective effect of a Hatakeshimeji (Lyophyllum decastes) on the radiation-induced malformation at the organogenesis stage, embryonic death and the effects of Hatakeshimeji (Lyophyllum decastes) on the In vivo level of the fetuses. ICR mouse from Japan National Institute of Health was used for the experiment. One or two female mice and one male mouse of shame age range were mated for only three hours from 8:00 to 11:00. The pregnant mice were placed in plastic cages for radiation exposure, and were treated with a single whole-body X -radiation at 1 Gy with a dose rate of 35 cGy/min on 8 days after the conception. 100 mg/kg of Hatakeshimeji (Lyophyllum decastes) (isotonic sodium chloride solution: 0.2 ml) was injected by i.p.route to the pregnant mice. The embryonic death, external malformations, fetal body weight, sex ratio and embryonic death were observed in these experiments.

  13. Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study

    Energy Technology Data Exchange (ETDEWEB)

    Cakmak G.; Miller L.; Zorlu, F.; Severcan, F.

    2012-03-03

    Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and grey matter (GM) regions of the rat brain were investigated at molecular level. Sprague-Dawley rats, which were administered amifostine or not, were whole-body irradiated at a single dose of 800 cGy, decapitated after 24 h and the brain tissues of these rats were analyzed using Fourier transform infrared microspectroscopy (FTIRM). The results revealed that the total lipid content and CH{sub 2} groups of lipids decreased significantly and the carbonyl esters, olefinic=CH and CH{sub 3} groups of lipids increased significantly in the WM and GM after exposure to ionizing radiation, which could be interpreted as a result of lipid peroxidation. These changes were more prominent in the WM of the brain. The administration of amifostine before ionizing radiation inhibited the radiation-induced lipid peroxidation in the brain. In addition, this study indicated that FTIRM provides a novel approach for monitoring ionizing radiation induced-lipid peroxidation and obtaining different molecular ratio images can be used as biomarkers to detect lipid peroxidation in biological systems.

  14. Does amifostine have radioprotective effects on salivary glands in high-dose radioactive iodine-treated differentiated thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Chao; Wang, Guoming; Zuo, Shuyao [Qingdao University, Department of Nuclear Medicine, Affiliated Hospital, Medical College, Qingdao, Shandong Province (China); Xie, Jiawei [Qingdao University, Medical College, Qingdao (China); Jiang, Zhongxin [Qingdao University, Affiliated Hospital, Medical College, Qingdao (China)

    2010-09-15

    To assess the effects of amifostine on salivary glands in radioactive iodine-treated differentiated thyroid cancer. We searched the MEDLINE, EMBASE and the Cochrane Library for randomized controlled clinical trials which compared the effects of amifostine with those of placebo or acid-stimulating agents. Two randomized controlled clinical trials with a total of 130 patients were included. Both studies had a low risk of bias. There were no statistically significant differences between the effects of amifostine and acid-stimulating agents on the incidence of xerostomia (RR 0.24, 95% CI 0.01 to 9.52), the decrease of scintigraphically measured uptake of {sup 99m}Tc by the parotid (RR 0.30, 95% CI -2.28 to 2.88) or submandibular glands (RR 1.90, 95% CI -1.46 to 5.26) at 12 months, or the reduction in blood pressure (RR 5.00, 95% CI 0.25 to 99.16). Neither of the included trials investigated death from any cause, morbidity, health-related quality of life or costs. The results of two randomized controlled clinical trials suggest that amifostine has no significant radioprotective effects on salivary glands in radioactive iodine treatment of differentiated thyroid cancer. The use of acid-stimulating agents to increase salivation should remain the first choice during radioactive iodine treatment of differentiated thyroid cancer. Patients should also be well informed of the importance of hydration and acid stimulation. (orig.)

  15. What is the Knowledge Society?

    Directory of Open Access Journals (Sweden)

    Marin Dinu

    2008-02-01

    Full Text Available This study sets out to establish conceptual delimitations, more concordant to the theoretical acquisitions with regard to the knowledge society. The author considers it opportune to situate in the center of the definition of the concept of knowledge society the problem of prevalence in the typology of resources. Thus, the knowledge society appears as a form of organization in which scientific knowledge predominates, be that informatics as well. The concordances of essence are discovered through the discerning of the functional relationship knowledge society – global society. In the spectrum of meanings specific to this highway of post-postmodernist configuration of the world, the priorities of the project of the second modernity – the paradigmatic matrix of globalization – are approached. In fact, the study argues in favor of refocusing globalization on the humane, on its distinctive values which substantiate and lend sense to the evolutions of the world. Postreferentiality is the rational expression of humanity coming back to itself.

  16. Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor

    International Nuclear Information System (INIS)

    Interleukin 1 alpha (IL-1 alpha), tumor necrosis factor alpha (TNF alpha), granulocyte-colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) are molecularly distinct cytokines acting on separate receptors. The release of these cytokines can be concomitantly induced by the same signal and from the same cellular source, suggesting that they may cooperate. Administered alone, human recombinant (hr)IL-1 alpha and hrTNF alpha protect lethally irradiated mice from death, whereas murine recombinant GM-CSF and hrG-CSF do not confer similar protection. On a dose basis, IL-1 alpha is a more efficient radioprotector than TNF alpha. At optimal doses, IL-1 alpha is a more radioprotective cytokine than TNF alpha in C57BL/6 and B6D2F1 mice and less effective than TNF alpha in C3H/HeN mice, suggesting that the relative effectiveness of TNF alpha and IL-1 alpha depends on the genetic makeup of the host. Administration of the two cytokines in combination results in additive radioprotection in all three strains. This suggests that the two cytokines act through different radioprotective pathways and argues against their apparent redundancy. Suboptimal, nonradioprotective doses of IL-1 alpha also synergize with GM-CSF or G-CSF to confer optimal radioprotection, suggesting that such an interaction may be necessary for radioprotection of hemopoietic progenitor cells

  17. Insertion of Argentine firms in global value chains not oriented to the mass market: The cases of high-end footwear and the Basso group

    OpenAIRE

    González, Andrea; Hallak, Juan Carlos; Schott, Peter; Genta, Tatiana Soria

    2012-01-01

    This paper describes experiences of international insertion of Argentine producers of manufactured goods not oriented to the mass market. Based on these experiences, we develop a typology of potential alternatives of international insertion for this type of goods centered on the role of local agents in design activities. Our analysis follows the global value chain (GVC) approach and emphasizes the links between local producers and buyers in developed countries. First, we analyze experiences o...

  18. The effects of nitric oxide cooling and the photodissociation of molecular oxygen on the thermosphere/ionosphere system over the Argentine Islands

    OpenAIRE

    G. D. Wells; Rodger, A. S.; Moffett, R. J.; G. J. Bailey; Fuller-Rowell, T. J.

    1997-01-01

    In the past the global, fully coupled, time-dependent mathematical model of the Earth's thermosphere/ionosphere/plasmasphere (CTIP) has been unable to reproduce accurately observed values of the maximum plasma frequency, foF2, at extreme geophysical locations such as the Argentine Islands during the summer solstice where the ionosphere remains in sunlight throughout the day. This is probably because the seasonal dependence of thermospheric cooling by 5.3 µm nitric oxid...

  19. Argentine activities related to the development of low enriched fuel elements

    International Nuclear Information System (INIS)

    Within the framework of the RERTR Program and supported by the technical cooperation work agreed upon between the U.S.A. and Argentina in May 1979, the CNEA Nuclear Fuel Department - Low Enriched Fuel Elements Project (ECBE Project), has carried on its own program for developing fuels with low enrichment for research and test reactors. Up to the present, its main objective has been to replace the highly enriched fuel used in its only reactor (RA-3) for research, development and radioisotopes production. The basic stages of the Argentine Program are shown in Table 1. At a meeting held in Vienna in March, 1980, the CNEA stated that its development of fuels with low enrichment would be in two fuel lines: UAlx-Al and U3O8-Al, and that its aim would be to reach uranium densities of 18-2.2 g/cm3 for the UAIx-Al line and 2.4-3.0 g/cm3 for the U3O8 line. At the international meeting held at ANL in November, 1980, and after having received depleted uranium and uranium with 20% and 45% enrichment (purchased from the U.S.A. for manufacturing miniplates and possible standard fuels) to carry on the proposed development, CNEA anticipated -- after its first tests -- that the conditions were satisfactory for reaching uranium densities of 2.4-3.0 g/cm3 in U3O8-Al fuel and of 2.4 g/cm3 in UAIx-Al fuel. In February 1981, after Argentina accepted the obligation of paying for the irradiation service, authorization was obtained for irradiating miniplates in the Oak Ridge Reactor within the RERTR Program. In June 1981, the first set of miniplates was sent to Oak Ridge National Laboratory (ORNL). The maximum actual densities reached at that time were 3.12 g/cm3 with U3O8-Al and 2.52 g/cm3 with UAlx-Al. During a visit of the CNEA Project Technical Manager to the Argonne National Laboratory (ANL) in July 1981, and after exchanging ideas with ANL professional staff, the CNEA decided to incorporate a new line of development, that of U3Si-Al. Three months later, in October 1981 a second set of

  20. Violence in society

    Directory of Open Access Journals (Sweden)

    António Pedro de Andrade Dores

    2014-07-01

    Full Text Available The recent interest in the sociology of violence has arisen at the same time that western societies are being urged to consider the profound social crisis provoked by global financial turmoil. Social changes demand the evo- lution of sociological practices. The analysis herein proposed, based on the studies of M. Wieviorka, La Violence (2005, and of R. Collins, Violence: A Micro-sociological Theory (2008, concludes that violence is subject to sociological treatments cen- tered on the aggressors, on the struggles for power and on male gender. There is a lack of connection between prac- tical proposals for violence prevention and the sociol- ogy of violence. It is accepted that violence as a subject of study has the potential, as well as the theoretical and social centrality, to promote the debate necessary to bring social theory up to date. This process is more likely to oc- cur in periods of social transformation, when sociology is open to considering subjects that are still taboo in its study of violence, such as the female gender and the state. The rise of the sociology of violence confronts us with a dilemma. We can either collaborate with the construc- tion of a sub discipline that reproduces the limitations and taboos of current social theory, or we can use the fact that violence has become a “hot topic” as an opportunity to open sociology to themes that are taboo in social the- ory (such as the vital and harmonious character of the biological aspects of social mechanisms or the normative aspects of social settings. ResumenEl interés reciente en la sociología de la violencia ha surgido al mismo tiempo que las sociedades occidenta- les están requiriendo considerar la profunda crisis social provocada por la agitación financiera global. Los cambios sociales demandan la evolución de las prácticas socioló- gicas. El análisis aquí expuesto, basado en los estudios de M. Wieviorka, La Violence (2005, and of R. Collins